title: Chiral arylpyrrolidinols: preparation and biological profile.
abstract: The preparation and biological evaluation of a new class of arylpyrrolidinols is reported. The antinociceptive activity was evaluated in vivo with the hot plate test (HPT) and formalin test (FT), excluding any involvement on motor coordination with the rota-rod test (RRT). The nociceptive behavior in the late phase of FT (representative of chronic pain) suggests an involvement of the antiinflammatory process and it is clearly influenced by the stereochemical features, being the eutomer of phenylpyrrolidinols, the (2R,3S) enantiomer. Despite this, a specific mechanism of action is not yet clarified.
authors.affiliation: Dipartimento di Chimica Farmaceutica, Università di Pavia, Viale Taramelli, 12, I-27100 Pavia, Italy. simona.collina@unipv.it
authors.forename: Simona
authors.initials: S
authors.lastname: Collina
authors.forename: Daniela
authors.initials: D
authors.lastname: Rossi
authors.forename: Guya
authors.initials: G
authors.lastname: Loddo
authors.forename: Annalisa
authors.initials: A
authors.lastname: Barbieri
authors.forename: Enrica
authors.initials: E
authors.lastname: Lanza
authors.forename: Laura
authors.initials: L
authors.lastname: Linati
authors.forename: Stefano
authors.initials: S
authors.lastname: Alcaro
authors.forename: Andrea
authors.initials: A
authors.lastname: Gallelli
authors.forename: Ornella
authors.initials: O
authors.lastname: Azzolina
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D018360:Crystallography, X-Ray; D008297:Male; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D010146:Pain / Q000188:drug therapy; D010147:Pain Measurement / Q000187:drug effects; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D000700:Analgesics; D011759:Pyrrolidines