title: Cytotoxic flavonoids from Platymiscium floribundum.
abstract: Two new isoflavonoids, 7-hydroxy-6,4'-dimethoxy-isoflavonequinone (1) and 2'-hydroxy-6,4',6' ',4' ''-tetramethoxy-[7-O-7' ']-bisisoflavone (2), and seven other known flavonoids, 3-hydroxy-9-methoxypterocarpan (medicarpin), 3,10-dihydroxy-9-methoxypterocarpan, 3,9-dimethoxypterocarpan (homopterocarpin) (3), 2,3,9-trimethoxypterocarpan (4), 3,4-dihydroxy-9-methoxypterocarpan (vesticarpan) (5), 2',4,4'-trihydroxychalcone (isoliquiritigenin), and 7,4'-dihydroxyflavanone (liquiritigenin) (6), were isolated from the heartwood of Platymiscium floribundum. The structures of compounds 1 and 2 were established by spectroscopic methods. Compounds 3-6 showed cytotoxic activity when evaluated against five human cancer cell lines in vitro.
authors.affiliation: Curso de Pós-Graduação em Química Orgânica, Departamento de Química Orgânica e Inorgânica, Centro de Ciências, Universidade Federal do Ceará, CP 12200, Fortaleza-Ce, 60021-940, Brazil.
authors.forename: Maria José C
authors.initials: MJ
authors.lastname: Falcão
authors.forename: Yvone Brígido M
authors.initials: YB
authors.lastname: Pouliquem
authors.forename: Mary Anne S
authors.initials: MA
authors.lastname: Lima
authors.forename: Nilce Viana
authors.initials: NV
authors.lastname: Gramosa
authors.forename: Letícia V
authors.initials: LV
authors.lastname: Costa-Lotufo
authors.forename: Gardênia Carmen G
authors.initials: GC
authors.lastname: Militão
authors.forename: Cláudia
authors.initials: C
authors.lastname: Pessoa
authors.forename: Manoel Odorico
authors.initials: MO
authors.lastname: de Moraes
authors.forename: Edilberto R
authors.initials: ER
authors.lastname: Silveira
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001938:Brazil; D004354:Drug Screening Assays, Antitumor; D007887:Fabaceae / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: C499924:2'-hydroxy-6,4',6'',4'''-tetramethoxy(7-O-7'')-bisisoflavone; C499923:7-hydroxy-6,4'-dimethoxy-isoflavonequinone; D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D007529:Isoflavones; D011809:Quinones