[EGF receptor in head and neck cancer].
EGFR is overexpressed and is associated with a poor prognosis in head and neck cancer. Among the biological and cellular effects resulting from EGFR targeting in head and neck cancer there is the capacity to restore apoptotic capacities. Other experimental results put into evidence that DNA-repair activity was reduced by the application of EGFR targeting agents. This context was in favor of a research oriented towards combination between anti-EGFR drugs and cytotoxic agents, particularly irradiation. Supra-additive cytotoxic effects have been observed at the experimental level when combining anti-EGFR drugs with irradiation in head and neck cancer. These experimental data were recently confirmed at the clinical level in locally advanced head and neck cancer.
Milano
M
M
Service pharmacie du CHU de Nice, hôpital de Tende, 06430 Tende, France. gerard.milano@nice.fnclcc.fr
D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis; D066246:ErbB Receptors / Q000037:antagonists & inhibitors / Q000096:biosynthesis* / Q000187:drug effects / Q000502:physiology; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000503:physiopathology*; D006801:Humans; D011379:Prognosis
D000970:Antineoplastic Agents; D066246:ErbB Receptors