title: DNA photocleavage and biological activity of a pyrene dihydrodioxin.
abstract: A pyrene dihydrodioxin has been synthesized, shown to bind to duplex DNA by intercalation, and cleave the phiX 174 supercoiled plasmid upon irradiation with UV light. This compound also exhibits cytotoxic activity at the micromolar range in a number of human cancer cell lines.
authors.affiliation: Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221-0172, USA.
authors.forename: Eric T
authors.initials: ET
authors.lastname: Mack
authors.forename: Dagne
authors.initials: D
authors.lastname: Birzniece
authors.forename: Darren R
authors.initials: DR
authors.lastname: Veach
authors.forename: William
authors.initials: W
authors.lastname: Coyle
authors.forename: R Marshall
authors.initials: RM
authors.lastname: Wilson
mesh_terms: D045744:Cell Line, Tumor; D004247:DNA / Q000378:metabolism / Q000528:radiation effects*; D004249:DNA Damage; D004147:Dioxins / Q000737:chemistry / Q000378:metabolism / Q000528:radiation effects*; D006801:Humans; D007364:Intercalating Agents / Q000737:chemistry / Q000378:metabolism / Q000528:radiation effects; D020014:K562 Cells; D011721:Pyrenes / Q000737:chemistry / Q000378:metabolism / Q000528:radiation effects*; D014466:Ultraviolet Rays
chemical_list: D004147:Dioxins; D007364:Intercalating Agents; D011721:Pyrenes; D004247:DNA