2'-Amino-alpha-chloroacetophenone as a valuable tool for the synthesis of conveniently-substituted alpha,beta-epoxychalcone derivatives.
The synthesis of conveniently substituted 2'-amino-alpha,beta-epoxychalcones is described. They were obtained through Darzens condensation of 2'-amino-3',5'-dimethoxy-alpha-chloroacetophenone with benzaldehydes. The latter can undergo different cyclization possibilities and afford a variety of flavonoid analogs with biological potential.
Blanc
Madeleine
M
Département de Pharmacochimie Moléculaire, UMR CNRS-UJF 5063. Faculté de Pharmacie de Grenoble, France.
Martin
Maud
M
Okombi
Sabrina
S
Boumendjel
Ahcène
A
D000096:Acetone; D000098:Acetophenones / Q000138:chemical synthesis*; D001547:Benzaldehydes / Q000737:chemistry; D047188:Chalcones / Q000138:chemical synthesis*; D003500:Cyclization; D005419:Flavonoids / Q000138:chemical synthesis; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy
C502176:2'-amino-alpha-chloroacetophenone; D000098:Acetophenones; D001547:Benzaldehydes; D047188:Chalcones; D005419:Flavonoids; D007202:Indicators and Reagents; D000096:Acetone