Chinikomycins A and B: isolation, structure elucidation, and biological activity of novel antibiotics from a marine Streptomyces sp. isolate M045.
In our screening of marine Streptomycetes for bioactive principles, two novel antitumor antibiotics designated as chinikomycins A (2a) and B (2b) were isolated together with manumycin A (1), and their structures were elucidated by a detailed interpretation of their spectra. Chinikomycins A (2a) and B (2b) are chlorine-containing aromatized manumycin derivatives of the type 64-pABA-2 with an unusual para orientation of the side chains. They exhibited antitumor activity against different human cancer cell lines, but were inactive in antiviral, antimicrobial, and phytotoxicity tests.
Li
Fuchao
F
Department of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.
Maskey
Rajendra P
RP
Qin
Song
S
Sattler
Isabel
I
Fiebig
Heinz H
HH
Maier
Armin
A
Zeeck
Axel
A
Laatsch
Hartmut
H
D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011090:Polyenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D053284:Polyunsaturated Alkamides; D013302:Streptomyces / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000903:Antibiotics, Antineoplastic; D011090:Polyenes; D053284:Polyunsaturated Alkamides; C499737:chinikomycin A; C499738:chinikomycin B; C054474:manumycin