Rabies virus receptors.
There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind rabies virus and/or facilitate rabies virus entry into cells. Other components of the cell membrane, such as gangliosides, may also participate in the entry of rabies virus. However, little is known of the role of these molecules in vivo. This review proposes a speculative model that accounts for the role of these different molecules in entry and trafficking of rabies virus into the nervous system.
Lafon
Monique
M
Unité de Neuroimmunologie Virale, Département de Neuroscience, Institut Pasteur, 75724 Paris cedex 15, France. mlafon@pasteur.fr
D000818:Animals; D006801:Humans; D019006:Neural Cell Adhesion Molecules / Q000378:metabolism; D009474:Neurons / Q000821:virology*; D011820:Rabies virus / Q000472:pathogenicity*; D020800:Receptor, Nerve Growth Factor; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism; D011978:Receptors, Nicotinic / Q000378:metabolism; D011991:Receptors, Virus
D019006:Neural Cell Adhesion Molecules; D020800:Receptor, Nerve Growth Factor; D017475:Receptors, Nerve Growth Factor; D011978:Receptors, Nicotinic; D011991:Receptors, Virus