title: [Treatment of paraungual HPV73-positive Bowen disease with imiquimod cream].
abstract: Bowen disease - a squamous cell carcinoma in situ - is associated with oncogenic human papilloma viruses (HPV). The association is best established for genital Bowen disease but also holds for extragenital lesions. The immunomodulatory substance imiquimod is used for the treatment of HPV-induced skin disorders. In the case of paraungual Bowen disease, established treatment options as excision, cryosurgery, radiotherapy or laser treatment might cause persistent nail damage. We successfully treated HPV73-positive Bowen disease in this location with topical imiquimod.
authors.affiliation: Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig Maximilians-Universität, München. peter.weisenseel@derma.med.uni-muenchen.de
authors.forename: P
authors.initials: P
authors.lastname: Weisenseel
authors.forename: J
authors.initials: J
authors.lastname: Prinz
authors.forename: H
authors.initials: H
authors.lastname: Korting
mesh_terms: D000287:Administration, Topical; D000634:Aminoquinolines / Q000008:administration & dosage*; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001913:Bowen's Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006801:Humans; D000077271:Imiquimod; D008297:Male; D008875:Middle Aged; D009260:Nail Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D009779:Occlusive Dressings; D027383:Papillomaviridae / Q000187:drug effects / Q000235:genetics; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D016133:Polymerase Chain Reaction; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D000077271:Imiquimod