[Primary meningeal intermediate grade melanocytic neoplasm: case report with radiologic-pathologic correlation].
A case of primary meningeal intermediate grade melanocytic neoplasm involving the right C2 nerve root is presented. MRI findings may suggest this rare entity, especially when an extra-axial lesion is located in the posterior fossa or cervical spinal canal and demonstrates shortening of both T1 and T2. Eventually, definitive diagnosis relies on histology which demonstrates spindle-shaped melanocytic cells that are Fontana stained and positive for HMB:45 antigen. Cellularity, pleomorphism, mitotic rate, proliferation index and invasiveness are useful criteria to distinguish among the spectrum of primary melanocytic tumors of the central nervous system ranging from melanocytoma to malignant melanoma.
Moser
T
T
Service de Radiologie 2, Hôpital de Hautepierre, avenue Molière, 67098 Strasbourg Cedex. moser_th@yahoo.fr
Nogueira
T S
TS
Fakhoury
W
W
Pfleger
N
N
Neuville
A
A
Kehrli
P
P
Beltechi
R
R
Serban
A
A
Silvestre
R
R
Dietemann
J L
JL
D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008545:Melanoma / Q000175:diagnosis* / Q000473:pathology; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D014057:Tomography, X-Ray Computed