Diffuse normolipemic plane xanthoma in a 9-year-old boy.
Normolipemic plane xanthoma normally occurs in adults. We report the atypical instance of a 9-year-old boy who developed disseminated, flat, yellow-brown plaques up to 2 to 3 cm without any complaints. The histology showed the hallmarks of xanthoma, including the presence of CD68+ foam cells and Touton giant cells. No systemic involvement or lipid disorders were evident. It is important to perform regular follow-up of these patients because normolipemic plane xanthoma often precedes myeloproliferative disorders such as leukemia, paraproteinemia, or lymphoma.
Hofmann
Maja
M
Department of Dermatology and Allergy, Charité, University Medicine Berlin, Germany. maja.hofmann@charite.de
Zappel
Kristina
K
Trefzer
Uwe
U
Audring
Heike
H
Albrecht-Nebe
Helga
H
Sterry
Wolfram
W
Blume-Peytavi
Ulrike
U
D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D001706:Biopsy; D002648:Child; D006801:Humans; D008297:Male; D012871:Skin Diseases / Q000378:metabolism / Q000473:pathology*; D014973:Xanthomatosis / Q000378:metabolism / Q000473:pathology*; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule