[Dual wavelength multiplication subtractive spectrophotometric determination of sulfadiazinum and trimethoprimum in compound sulfadiazine tablets].
This paper described the simultaneous determination of sulfadiazine (SD) and trimethoprim (TMP) in tablets co-Trimediazini by dual wavelength spectrophotometry multriplication subtractive method. This method was based on the measurement of both absorbance of standard solution of SD (8-14) x 10(-6)g/mL, TMP (1-2) x 10(-6)g/mL and sample solution at wavelength 242.5 nm and 228.0nm. The average recovery and RSD of SD and TMP were 100.60%, 0.33% and 98.27%, 1.58%, respectively (n=20). The method was simple, quick and results satisfactory.
Li
T
T
Department of Inorganic Chemistry of Pharmacy School of Hebei Medical University, 050017 Shi Jiazhuang.
Zhang
Z
Z
Yang
C
C
Liu
W
W
Cao
Y
Y
Wang
F
F
D004338:Drug Combinations; D015203:Reproducibility of Results; D013053:Spectrophotometry / Q000379:methods*; D013411:Sulfadiazine / Q000032:analysis* / Q000737:chemistry; D013607:Tablets; D013997:Time Factors; D014295:Trimethoprim / Q000032:analysis* / Q000737:chemistry; D000096926:Benzenesulfonamides
D004338:Drug Combinations; D013411:Sulfadiazine; D013607:Tablets; D014295:Trimethoprim; C024873:sulfadiazine, trimethoprim drug combination; D000096926:Benzenesulfonamides