[Prostate leiomiosarcoma. Report of three cases].
OBJECTIVE
Leiomyosarcoma of the prostate is an uncommon neoplasm with a poor prognosis. We review the three cases of leiomyosarcoma of the prostate observed in our hospital in the last twenty years and studied their clinical follow-up,


METHODS
We have found three cases and we have studied their clinical follow-up, immunohistochemical profile and ultrastructural features.


RESULTS
In all cases tumor cells were positive for vimentin and also for either desmin or actin. Two cases were considered grade III sarcomas, with an aggressive course even with treatment, they died 5 and 24 months later, respectively. The third case, was considered grade II and is still alive, 60 months after diagnosis, without evidence of disease.


CONCLUSIONS
Leiomyosarcoma of the prostate is an uncommon neoplasm that accounts for less than 0.1% of prostate tumors. We found no prognostic factors for predicting prolonged survival although complete resection and low mitotic activity may be predictive.
Amat Villegas
Irene
I
Servicio de Anatomía Patológica, Hospital de Navarra, Pamplona, España. ireneyander@wanadoo.es
Beloqui Perez
Raquel
R
Caballero Martínez
María Cristina
MC
Gómez Dorronsoro
María Luisa
ML
Larrínaga Liñero
Begoña
B
Cuesta Alcalá
José Angel
JA
Aldave Villanueva
Javier
J
D006801:Humans; D007890:Leiomyosarcoma / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000473:pathology