Fucoidan inhibits the development of proteinuria in active Heymann nephritis.
Fucoidan, the sulphated polysaccharide extracted from brown seaweed, has various biological activities. The effect of fucoidan on the formation of proteinuria and renal functions in active Heymann nephritis was investigated in this study. Active Heymann nephritis was induced by administering brush border protein of rat proximal uriniferous tubules (FX1A). Fucoidan was administered by oral intubation to Heymann nephritis rats at three doses (50, 100 and 200 mg/kg) once daily for 4 weeks. The elevated urinary protein excretion and plasma creatinine due to the induction of Heymann nephritis were significantly reduced by fucoidan at doses of 100 and 200 mg/kg. The results indicated that fucoidan has a renoprotective effect on active Heymann nephritis and is a promising therapeutic agent for nephritis.
Zhang
Quanbin
Q
Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, P.R. China. qbzhang@ms.qdio.ac.cn
Li
Ning
N
Zhao
Tingting
T
Qi
Huimin
H
Xu
Zuhong
Z
Li
Zhien
Z
D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005921:Glomerulonephritis / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D026541:Heymann Nephritis Antigenic Complex / Q000276:immunology; D007684:Kidney Tubules / Q000187:drug effects* / Q000276:immunology; D007795:Laminaria; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D011134:Polysaccharides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011507:Proteinuria / Q000209:etiology / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar
D026541:Heymann Nephritis Antigenic Complex; D010936:Plant Extracts; D011134:Polysaccharides; C007789:fucoidan