title: Interdigitating dendritic cell tumor with breast and cervical lymph-node involvement: a case report and review of the literature.
abstract: Interdigitating dendritic cell tumor (IDCT) is an extremely rare malignancy. It occurs primarily in lymph nodes, but extranodal involvement has also been reported. A 38-year-old woman with IDCT with breast and cervical lymph-node involvement is reported in this paper. To our knowledge, this is the first case of IDCT originating from the breast. In the breast and lymph node, the tumor displayed diffuse sheets, fascicles and storiform growth pattern. It was composed of oval to spindle cells with pale to eosinophilic cytoplasm, ill-defined cell outlines, oval nuclei with vesicular chromatin and prominent eosinophilic nucleoli. Mitotic activity was three per ten high-power fields. The neoplastic cells were intermingled with small mature lymphocytes and plasma cells. Immunohistochemical studies showed that the tumor cells were strongly and diffusely positive for vimentin, CD68, S-100 protein, CD45/leukocyte common antigen and fascin and focally positive for lysozyme, alpha-1 antitrypsin and CD4. Ki-67 labeling index was 10%. The patient was treated with combined therapeutic approaches, including surgery, radiotherapy and chemotherapy. IDCT has the potential for an aggressive clinical course. However, 32 months after the initial diagnosis, the patient is still alive and being followed with a stable tumor burden.
authors.affiliation: Department of Pathology, Gazi University Medical School, Ankara, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Uluoğlu
authors.forename: Nalan
authors.initials: N
authors.lastname: Akyürek
authors.forename: Aytuğ
authors.initials: A
authors.lastname: Uner
authors.forename: Uğur
authors.initials: U
authors.lastname: Coşkun
authors.forename: Ayşegul
authors.initials: A
authors.lastname: Ozdemir
authors.forename: Nahide
authors.initials: N
authors.lastname: Gökçora
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D001706:Biopsy; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D003713:Dendritic Cells / Q000737:chemistry / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017493:Leukocyte Common Antigens / Q000032:analysis; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000175:diagnosis* / Q000473:pathology; D015412:Mastectomy, Segmental; D009333:Neck; D049268:Positron-Emission Tomography; D009418:S100 Proteins / Q000032:analysis; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D014746:Vimentin / Q000032:analysis; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D017493:Leukocyte Common Antigens; D009418:S100 Proteins; D014746:Vimentin; C067980:CD68 antigen, human; D000097382:CD68 Molecule