Biodegradable microspheres of ketorolac tromethamine for parenteral administration.
Ketorolac tromethamine loaded microspheres were prepared using two different polyesters, namely poly (lactic acid) and poly (glycolic acid) by solvent evaporation technique. The morphology of microspheres was analysed by scanning electron microscopy. In vitro release profiles of these microspheres were studied in phosphate buffered saline pH 7.4. The release kinetics of ketorolac tromethamine from the microspheres was evaluated by fitting the release data to the zero-order, Higuchi and korsemeyer-peppas equations. All microspheres showed initial burst release, followed by fickian diffusion of drug through microspheres. These microspheres were formulated as parenterals to have controlled release system.
Bhaskaran
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Department of Pharmaceutics, Al-Ameen College of Pharmacy, Bangalore, India. vani3@hotmail.com
Suresh
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D001673:Biodegradation, Environmental; D003692:Delayed-Action Preparations; D004339:Drug Compounding / Q000379:methods; D006016:Glycolates; D006801:Humans; D007263:Infusions, Parenteral; D020911:Ketorolac Tromethamine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D019344:Lactic Acid; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage* / Q000493:pharmacokinetics
D003692:Delayed-Action Preparations; D006016:Glycolates; D010975:Platelet Aggregation Inhibitors; C031149:glycolic acid; D019344:Lactic Acid; D020911:Ketorolac Tromethamine