title: [Clinical evaluation of meningeal carcinomatosis associated with primary lung cancer].
abstract: We evaluated diagnosis and treatment of four cases of meningeal carcinomatosis associated with primary lung cancer: case 1; small cell carcinoma (64 years old), case 2; small cell carcinoma (50 years old), case 3; adenocarcinoma (53 years old), and case 4; adenocarcinoma (55 years old). Determination of tumor markers in cerebrospinal fluid (CSF) together with the MRI findings that Gd-DTPA-enhanced T1-weighted image showing high intensity signal along the spinal cord was clinically useful in the diagnosis of meningeal carcinomatosis. Two of four patients received intrathecal chemotherapy and/or CSF drainage through Ommaya-Reservoir, resulting in dramatic improvement of various symptoms such as motor weakness and vesicorectal disorder. Intrathecal chemotherapy and placement of an Ommaya-Reservoir for CSF drainage should be considered to provide better Quality of Life (QOL) when patient can tolerate it.
authors.affiliation: Department of Respiratory Medicine, Juntendo University School of Medicine.
authors.forename: Akihito
authors.initials: A
authors.lastname: Yamamoto
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Takahashi
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Morio
authors.forename: Yoko
authors.initials: Y
authors.lastname: Gunji
authors.forename: Naoko
authors.initials: N
authors.lastname: Iwakami
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Kajiyama
authors.forename: Masataka
authors.initials: M
authors.lastname: Yoshioka
authors.forename: Kayo
authors.initials: K
authors.lastname: Miura
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Suzuki
authors.forename: Akihiko
authors.initials: A
authors.lastname: Ohwada
authors.forename: Koichi
authors.initials: K
authors.lastname: Sato
authors.forename: Yoshinosuke
authors.initials: Y
authors.lastname: Fukuchi
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D001932:Brain Neoplasms / Q000188:drug therapy / Q000556:secondary; D018288:Carcinoma, Small Cell / Q000556:secondary; D019786:Gadolinium DTPA; D006801:Humans; D007260:Infusion Pumps; D008175:Lung Neoplasms / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000556:secondary; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D000964:Antimetabolites, Antineoplastic; D019786:Gadolinium DTPA; D008727:Methotrexate