Profiling cytogenetic diversity with entropy-based karyotypic analysis.
Regardless the high degree of variation observed in solid tumor karyotypes, the use of diversity as a measurable phenomenon remains unexplored. Here we present a systematic cytogenetic analysis using Shannon's entropy as a measure for karyotypic diversity. Karyotypes from 14 epithelial tumor types (n = 1232) have the aneuploidy status scored, resulting in highly asymmetrical sample distribution, for which we determine the index of diversity (Shannon H') of structural and numerical chromosomal aberrations. Since karyotypic diversity is tissue-specific, this approach may give rise to new insights into the processes that may account for aneuploidy progression and solid tumor outcomes.
Castro
Mauro A A
MA
Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600-anexo (Lab. 25), Porto Alegre 90035-003, Brazil. mauro@ufrgs.br
Onsten
Tor T G
TT
de Almeida
Rita M C
RM
Moreira
José C F
JC
D002869:Chromosome Aberrations; D019277:Entropy; D020869:Gene Expression Profiling; D014644:Genetic Variation; D006801:Humans; D007621:Karyotyping; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics*