title: International development of the Parents' Index of Quality of Life in Atopic Dermatitis (PIQoL-AD).
abstract: OBJECTIVE
  The international development of the Parents' Index of Quality of Life in Atopic Dermatitis (PIQoL-AD), a quality of life (QoL) instrument specific to parents of children with atopic dermatitis (AD) is described.
  
  
  METHODS
  The instrument was developed simultaneously in several countries. Its content was derived from 65 qualitative interviews with parents in the UK, Netherlands and Italy. The measure was then produced for the UK, Netherlands, Italy, Germany, France, US and Spain. Field-test interviews were conducted with approximately 20 patients in each country to assess face and content validity. A two time-point survey was conducted with between 45 and 328 parents in each country to finalise the instrument through application of the Rasch model and to evaluate the psychometric properties of the final instrument.
  
  
  RESULTS
  Application of the Rasch model to the survey data identified the final 28-item version. All language versions had good item fit, test-retest reliability (above 0.85), internal consistency and promising validity.
  
  
  CONCLUSIONS
  The PIQoL-AD is a valuable instrument for inclusion in clinical trials and routine clinical practice. It provides distinct and complementary information to that of existing dermatology-specific measures and has been shown to be responsive to changes in QoL in clinical trials.
authors.affiliation: Galen Research, Manchester, UK. smckenna@galen-research.com
authors.forename: Stephen P
authors.initials: SP
authors.lastname: McKenna
authors.forename: Diane
authors.initials: D
authors.lastname: Whalley
authors.forename: Abigail L
authors.initials: AL
authors.lastname: Dewar
authors.forename: Ruud A M
authors.initials: RA
authors.lastname: Erdman
authors.forename: Thomas
authors.initials: T
authors.lastname: Kohlmann
authors.forename: Mauro
authors.initials: M
authors.lastname: Niero
authors.forename: Eva
authors.initials: E
authors.lastname: Baró
authors.forename: Sharon A
authors.initials: SA
authors.lastname: Cook
authors.forename: Beatrice
authors.initials: B
authors.lastname: Crickx
authors.forename: Feride
authors.initials: F
authors.lastname: Frech
authors.forename: Daniel
authors.initials: D
authors.lastname: van Assche
mesh_terms: D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000503:physiopathology* / Q000523:psychology; D005060:Europe; D006801:Humans; D007223:Infant; D007407:Interviews as Topic; D010290:Parents / Q000523:psychology*; D011788:Quality of Life; D006113:United Kingdom; D014481:United States