title: Tetrahydroisoquinoline 1-carboxamides as growth hormone secretagogues.
abstract: Several novel series of tetrahydroisoquinoline 1-carboxamides were prepared and shown to be potent growth hormone (GH) secretagogues. Among them, carbamate 12a-E2 displays excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model.
authors.affiliation: Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 5400, Princeton, NJ 08543, USA.
authors.forename: James J
authors.initials: JJ
authors.lastname: Li
authors.forename: Haixia
authors.initials: H
authors.lastname: Wang
authors.forename: Fucheng
authors.initials: F
authors.lastname: Qu
authors.forename: Christa
authors.initials: C
authors.lastname: Musial
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Tino
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Robl
authors.forename: Dorothy
authors.initials: D
authors.lastname: Slusarchyk
authors.forename: Rajasree
authors.initials: R
authors.lastname: Golla
authors.forename: Ramakrishna
authors.initials: R
authors.lastname: Seethala
authors.forename: Kenneth
authors.initials: K
authors.lastname: Dickinson
authors.forename: Leah
authors.initials: L
authors.lastname: Giupponi
authors.forename: Gary
authors.initials: G
authors.lastname: Grover
authors.forename: Paul
authors.initials: P
authors.lastname: Sleph
authors.forename: Neil
authors.initials: N
authors.lastname: Flynn
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Murphy
authors.forename: David
authors.initials: D
authors.lastname: Gordon
authors.forename: Melissa
authors.initials: M
authors.lastname: Kung
authors.forename: Robert
authors.initials: R
authors.lastname: Stoffel
mesh_terms: D000818:Animals; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D057927:Hydrophobic and Hydrophilic Interactions; D008956:Models, Chemical; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D043562:Receptors, G-Protein-Coupled / Q000097:blood / Q000378:metabolism*; D054440:Receptors, Ghrelin; D044005:Tetrahydroisoquinolines / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D009842:Oligopeptides; D043562:Receptors, G-Protein-Coupled; D054440:Receptors, Ghrelin; D044005:Tetrahydroisoquinolines; C041048:growth hormone releasing hexapeptide; D013006:Growth Hormone