"Proximal-type" and classic epithelioid sarcomas represent a clinicopathologic continuum: case report.
We report a case of an epithelioid sarcoma that occurred in the right hand of a 14-year-old boy and had the "proximal-type" morphology and a complex, near-tetraploid karyotype. The tumor metastasized to the lungs, where the morphology was typical for the classic epithelioid sarcoma. Based on the morphologic and cytogenetic findings in this case, we suggest that the proximal-type and the classic epithelioid sarcomas are not distinct entities but represent a continuum.
Rakheja
Dinesh
D
Department of Pathology, Children's Medical Center of Dallas, 1935 Motor Street, Dallas, TX 75235, USA.
Wilson
Kathleen S
KS
Meehan
John
J
Schultz
Roger A
RA
Gomez
Ana M
AM
D000293:Adolescent; D000782:Aneuploidy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D017024:Chemotherapy, Adjuvant; D003520:Cyclophosphamide / Q000627:therapeutic use; D005047:Etoposide / Q000627:therapeutic use; D006225:Hand; D006801:Humans; D007124:Immunoenzyme Techniques; D017403:In Situ Hybridization; D008175:Lung Neoplasms / Q000235:genetics / Q000556:secondary / Q000628:therapy; D008297:Male; D012509:Sarcoma / Q000737:chemistry / Q000235:genetics / Q000556:secondary* / Q000628:therapy; D012983:Soft Tissue Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D032681:Spectral Karyotyping
D014408:Biomarkers, Tumor; D005047:Etoposide; D003520:Cyclophosphamide