title: Barriers to interferon-alpha therapy are higher in intravenous drug users than in other patients with acute hepatitis C.
abstract: OBJECTIVE
  Treatment with interferon-alpha (IFN-alpha) may eradicate HCV in most acute hepatitis C patients, thus preventing chronic hepatitis and avoiding less efficacious combination therapy.
  
  
  METHODS
  In a prospective study, we evaluated the impact of barriers to successful start and completion of treatment of acute and subacute (<12 months from infection) hepatitis C with pegylated IFN-alpha2b, 1.5 microg/kg, QW, for 24 weeks.
  
  
  RESULTS
  Out of 27 patients (22 were active intravenous drug users [IVDU]), 5 cleared HCV spontaneously. Antiviral treatment was indicated in 22 patients: six refused therapy for fear of side effects, whereas two others were lost to observation. Eight patients completed the treatment or received >80% of the scheduled drug: seven (88%) were sustained virological responders 24 weeks after the end of treatment. Six patients (all IVDU) stopped prematurely due to side effects: only one had a sustained virological response. Based on an intent-to-treat analysis, and considering all 14 patients in whom at least one dose of drug was administered, only 8 (57%) became sustained virological responders.
  
  
  CONCLUSIONS
  Treatment of acute hepatitis C with pegylated IFN-alpha is highly beneficial, but its effectiveness is affected by a poor rate of acceptance and/or adherence to currently available regimens, especially in IVDU and women.
authors.affiliation: Département de Médecine Communautaire, University Hospitals, Geneva, Switzerland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Broers
authors.forename: Beat
authors.initials: B
authors.lastname: Helbling
authors.forename: Anne
authors.initials: A
authors.lastname: François
authors.forename: Patrick
authors.initials: P
authors.lastname: Schmid
authors.forename: Christian
authors.initials: C
authors.lastname: Chuard
authors.forename: Antoine
authors.initials: A
authors.lastname: Hadengue
authors.forename: Francesco
authors.initials: F
authors.lastname: Negro
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D006505:Hepatitis / Q000453:epidemiology / Q000821:virology; D006526:Hepatitis C / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D010349:Patient Compliance; D011092:Polyethylene Glycols; D011994:Recombinant Proteins; D015819:Substance Abuse, Intravenous; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; C417083:peginterferon alfa-2b