Copper-metalated peptide palindrome derived from prion octarepeat: synthesis, aggregation, and oxidative transformations.
We report construction of a bis-pentapeptide conjugate 4 containing truncated pentapeptide sequence from prion octarepeats. Its copper-laden derivative 5 demonstrated a propensity for aggregate formation, which was studied by atomic force microscopy. Oxidative biochemical transformations catalyzed by 5 were evaluated by nucleic acid cleavage and by neurotransmitter oxidation, in the presence of external co-oxidants. Preliminary mechanistic analysis provides a hint for the involvement of reactive oxygen species in such transformations.
Madhavaiah
C
C
Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, India.
Verma
Sandeep
S
D020816:Amino Acid Motifs / Q000502:physiology; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D008968:Molecular Conformation; D009696:Nucleic Acids / Q000737:chemistry; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry*; D010084:Oxidation-Reduction; D011328:Prions / Q000138:chemical synthesis* / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000737:chemistry; D020449:Repetitive Sequences, Amino Acid / Q000502:physiology; D021241:Spectrometry, Mass, Electrospray Ionization
D009696:Nucleic Acids; D009842:Oligopeptides; D011328:Prions; D017382:Reactive Oxygen Species; D003300:Copper