[Digestive bleeding and anti-inflammatory drugs at the teaching hospital of Brazzaville].
Authors relate a retrospective survey of 140 cases of digestive haemorrhage after intake of anti-inflammatory drugs from January 1988 to December 2000. The digestive haemorrhage frequency after intake of anti-inflammatory drugs reaches 16%. This survey included 94 men and 46 women whose average age is 42.3 years, with extremes of 15 and 79 years. Among these patients, 75 took salicylic acetyl acid (SAA), 56 non-steroidal anti-inflammatory drug (NSAID) and 9 the SAA and NSAID association. More than half of patients relied on self-medication (91 cases ie. 65%). The haematemesis followed by melaena induced the most frequent bleeding (42.8% of cases), while the isolated haematemesis, the isolated melaena and the isolated rectal haemorrhage were found respectively in 35%, 15% and 7.2%. Haemorrhages occur early under SAA and seem less severe than those occurring under NSAID. Lesions responsible for the bleeding are: the duodenal ulcer (68.7%), the haemorrhagic gastritis (6.4%), the gastric ulcer (5%), the oesophagitis (4.2%), the gastric and duodenal ulcer association (3.5%), anorectal exsudative pains and haemorrhagic anal ulcerations. The duodenal ulcer predominance could be attributed to previous lesions.
Gassaye
D
D
Service de gastro-entérologie et médecine interne, CHU, BP 32, Brazzaville, Congo. debygassaye@yahoo.fr
Atipo Ibara
B I
BI
Ndolo-Mpika
A B
AB
Ibara
J R
JR
Okouo
M
M
Ossendza
R A
RA
Ngoma-Mambouana
Ph
P
Itoua-Ngaporo
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects; D015897:Comorbidity; D003223:Congo / Q000453:epidemiology; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced* / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin