Adiponectin as a protective factor in hepatic steatosis.
OBJECTIVE
Obesity and insulin resistance (IR) are closely related to hepatic steatosis (HS), and adiponectin is a hepatic insulin sensitizer that has important effects in liver function. This study aims at investigating the relationship between serum adiponectin concentration and the presence of HS.


METHODS
We carried out a cross-sectional study in a check-up unit of a University Hospital in Mexico City. We enrolled 196 subjects, comprising 98 subjects with HS (27 women, 71 men) and 98 controls (37 women and 61 men). Anthropometric, metabolic and biochemical variables were measured in the two groups. Serum adiponectin and leptin concentrations were determined, their association with grade of HS tested, and concentrations, according to quartiles, compared between cases and controls. chi(2) analysis for linear trends was used to test for a dose-response relationship and logistic regression analysis was conducted to test for a protective effect of adiponectin.


RESULTS
The HS subjects were older and more obese than controls, with a central obesity pattern. In the fourth quartile of adiponectin concentrations, HS was less common and severe. In a multivariate model of the fourth quartile of the adiponectin concentrations, we observed a protective effect (OR = 0.17, 95%CI: 0.04-0.67, P = 0.01). In subjects with more severe HS, we observed higher leptin concentrations, and caloric intakes, total fat and iron consumption were higher than in controls.


CONCLUSIONS
The results of the present study suggest that a high serum concentration of adiponectin is associated with a protective effect against HS.
Mendez-Sanchez
Nahum
N
Department of Biomedical Research, Gastroenterology and Liver Unit, Medica Sur Clinic and Foundation, Puente de Piedra 150, Col. Toriello Guerra, Mexico City, Mexico. nmendez@medicasur.org.mx
Chavez-Tapia
Norberto-C
NC
Villa
Antonio-R
AR
Sanchez-Lara
Karla
K
Zamora-Valdes
Daniel
D
Ramos
Martha-H
MH
Uribe
Misael
M
D052242:Adiponectin; D000328:Adult; D003430:Cross-Sectional Studies; D002149:Energy Intake; D005234:Fatty Liver / Q000097:blood*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D020738:Leptin / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015596:Nutrition Assessment; D009765:Obesity / Q000097:blood
D052242:Adiponectin; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin