title: Solvent-free synthesis of functionalized flavones under microwave irradiation.
abstract: [reaction: see text] Eco-friendly direct solvent-free synthesis of flavones is achieved by microwave irradiation of phloroglucinol and beta-ketoesters. Heating with microwaves versus under classical conditions was shown to be higher yielding, cleaner, and faster. The reaction goes through a cycloaddition of an alpha-oxo ketene intermediate followed by an uncatalyzed thermal Fries rearrangement.
authors.affiliation: Departamento de Química Orgánica, Universidad de Santiago de Compostela, Facultad de Ciencias, Aptdo. 280, 27080-Lugo, Spain. qoseijas@lugo.usc.es
authors.forename: Julio A
authors.initials: JA
authors.lastname: Seijas
authors.forename: M Pilar
authors.initials: MP
authors.lastname: Vázquez-Tato
authors.forename: Raquel
authors.initials: R
authors.lastname: Carballido-Reboredo
mesh_terms: D047309:Flavones / Q000138:chemical synthesis* / Q000737:chemistry; D008872:Microwaves; D012997:Solvents / Q000737:chemistry*
chemical_list: D047309:Flavones; D012997:Solvents