[Pellagra and panniculitis induced by chronic bacterial colonisation of the small intestine].
BACKGROUND
Pellagra is an exceptional disorder in France. The classical description of pellagra associates a photoinduced rash with neurological impairment and intestinal dysfunction. Without adapted treatment, the progression is fatal.


METHODS
A 62 year-old women developed a photoinduced rash, composed of circular and erythematous elements with pustular edges. She also had panniculitis, peripheral neuropathy, depressive mood and diarrhea. Her medical past was marked by epilepsy treated with sodium valproate and hydantoin. Biological exams revealed lowered plasma levels of vitamins PP, B1, B6 and zinc, secondary to intestinal impairment induced by bacteria proliferating in the small intestine. The rash resolved with vitamin PP and zinc supplementation. The bacterial colonisation was improved by long-term, sequential antibiotics.


CONCLUSIONS
We report a rare clinical form of pellagroid rash. The rash was induced by chronic malabsorption resulting from excessive bacterial proliferation in the diverticules of the small intestine. The antiepileptic treatment could have facilitated vitamin PP et zinc deficiency. Panniculitis was related to the bacterial proliferation. We discuss in this paper the relationship between some vitamin deficiencies, their clinical manifestations and the direct role of intestinal bacterial proliferation in the cutaneous manifestations.
Wierzbicka
E
E
Service de Dermatologie, CHU de Tours, France.
Machet
L
L
Karsenti
D
D
Fontès
V
V
Machet
M-C
MC
Guitton-Oudet
E
E
Lorette
G
G
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001419:Bacteria / Q000254:growth & development; D001765:Blind Loop Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D007421:Intestine, Small / Q000382:microbiology*; D008027:Light; D008875:Middle Aged; D015434:Panniculitis / Q000209:etiology* / Q000382:microbiology; D010383:Pellagra / Q000209:etiology* / Q000382:microbiology*
D000900:Anti-Bacterial Agents