title: Juvenile nasopharyngeal angiofibroma: a single institution study.
abstract: BACKGROUND
  Juvenile nasopharyngeal angiofibroma (JNA) is a rare tumor of adolescent males and there is a paucity of Indian studies on this subject.
  
  
  OBJECTIVE
  To present the experience of management of JNA at a single institution.
  
  
  METHODS
  This is a retrospective observational study of patients with JNA who presented at the Tata Memorial Hospital between May 1988 and August 2001.
  
  
  METHODS
  Thirty-two patients with JNA were treated in the study period. Since the time period was prolonged and diagnostic and therapeutic protocols had undergone many changes, the patients were divided into two groups, namely 1988-1996 and 1997-2001. The age distribution, disease patterns, management approaches and treatment outcomes of patients in the two groups were recorded. Statistical analyses were done using students 't' test and test for proportion.
  
  
  RESULTS
  The mean age at presentation was 16 years and more than 90% of the patients had Stage III or IV disease. Preoperative embolization was carried out in 19 patients. The surgical approaches used were median maxillectomy, infratemporal fossa, transpalatal, maxillary swing and craniofacial approach. The recurrence rate, complete resection rate and cure rates were 12.5%, 41% and 63% respectively.
  
  
  CONCLUSIONS
  Surgery is the mainstay of treatment of JNA. Preoperative embolization and newer surgical approaches result in less blood loss and complete resection. Aggressive re-resection should be done for resectable recurrences reserving radiotherapy for unresectable, recurrent/ residual disease.
authors.affiliation: Department of Head and Neck services, Tata Memorial Hospital, Ernest Borges Road, Parel, Mumbai, India. musica@vsnl.com
authors.forename: Rajesh C
authors.initials: RC
authors.lastname: Mistry
authors.forename: Sajid S
authors.initials: SS
authors.lastname: Qureshi
authors.forename: Shaikat
authors.initials: S
authors.lastname: Gupta
authors.forename: Sameer
authors.initials: S
authors.lastname: Gupta
mesh_terms: D000293:Adolescent; D000328:Adult; D018322:Angiofibroma / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008499:Medical Records; D009303:Nasopharyngeal Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology / Q000628:therapy; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology / Q000628:therapy; D009367:Neoplasm Staging; D013517:Otorhinolaryngologic Surgical Procedures / Q000706:statistics & numerical data; D011183:Postoperative Complications; D012189:Retrospective Studies