title: Impact of clarithromycin resistance on eradication of Helicobacter pylori in infected adults.
abstract: The outcome of Helicobacter pylori infection was analyzed in 114 dyspeptic patients treated with triple-drug therapy including clarithromycin. Clarithromycin resistance (in 20.2% of our isolates) was mainly caused by an A2142G mutation in the 23S rRNA gene of H. pylori. H. pylori eradication was obtained in all patients with clarithromycin-susceptible isolates but not in any patients with clarithromycin-resistant isolates (P = 0.0001). Therefore, it would be useful to conduct H. pylori antimicrobial susceptibility testing of the first gastric biopsy culture before choosing the first three drugs for therapy of infected patients.
authors.affiliation: Research Center for Gastroenterology, Dankook University College of Medicine, Cheonan, Choongnamdo, Republic of Korea.
authors.forename: Jong Hwa
authors.initials: JH
authors.lastname: Lee
authors.forename: Ji-Hyun
authors.initials: JH
authors.lastname: Shin
authors.forename: Im Hwan
authors.initials: IH
authors.lastname: Roe
authors.forename: Seung Ghyu
authors.initials: SG
authors.lastname: Sohn
authors.forename: Jung Hun
authors.initials: JH
authors.lastname: Lee
authors.forename: Geun Ho
authors.initials: GH
authors.lastname: Kang
authors.forename: Han-Ki
authors.initials: HK
authors.lastname: Lee
authors.forename: Byeong Chul
authors.initials: BC
authors.lastname: Jeong
authors.forename: Sang Hee
authors.initials: SH
authors.lastname: Lee
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017291:Clarithromycin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D005260:Female; D020459:Genes, rRNA; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009154:Mutation; D010437:Peptic Ulcer / Q000382:microbiology; D012338:RNA, Ribosomal, 23S / Q000235:genetics; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D012338:RNA, Ribosomal, 23S; D017291:Clarithromycin