title: Novel chemoselective tosylation of the alcoholic hydroxyl group of syn-alpha,beta-disubstituted beta-hydroxy carboxylic acids.
abstract: [small beta]-Hydroxy acids were readily converted into [small beta]-tosyloxy acids (hydroxyl group activation) in moderate to excellent yields via the O,O-dianions generated by treatment with methyllithium and thus make it possible to prepare anti[small alpha],[small beta]-disubstituted [small beta]-lactones directly from the syn aldols.
authors.affiliation: State Key Laboratory of Bioorganic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China. yikangwu@mail.sioc.ac.cn
authors.forename: Yikang
authors.initials: Y
authors.lastname: Wu
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Sun
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D006900:Hydroxylation; D015394:Molecular Structure
chemical_list: D000438:Alcohols; D002264:Carboxylic Acids