[Effects of jiantai liquid on the expression of estrogen/progesterone receptors in embryo implantation dysfunction mice endometrium].
OBJECTIVE
To explore the mechanism of Jiantai liquid on the endometrium development of embryo implantation dysfunction mice.


METHODS
The model of embryo implantation dysfunction mice was induced by mifepristone and treated by Jiantai liquid. All animals were sacrificed on day 8 of pregnancy. Estradiol and progesterone concentrations in serum and endometrium tissue homogenates were measured by radioimmunoassay method, the endometial expressions of estrogen receptor (ER)and progesterone receptor (PR)assessed by immunohistochemical SP method.


RESULTS
There were no significantly differences in the estradiol and progesterone concentrations in serum and uterus tissue homogenates among three groups( P > 0.05). Absorbency and area rate of ER, PR in model group' s gland and stroma were higher than those in model group(P < 0.05), which was similar with the control group( P > 0.05).


CONCLUSIONS
Jiantai liquid increase the implantation rate and improve the endometrial development by increasing the expressions of ER, PR in endometrium of embryo implantation dysfunction
Liu
Yan-juan
YJ
Deparment of Integrated Traditional Chinese & Western Medicine, Tongji Hospital, Wuhan 430030, China. tjyjliu@hotmail.com
Huang
Guang-ying
GY
Yang
Ming-wei
MW
Lu
Fu-er
FE
Gong
Ping
P
D000818:Animals; D027885:Astragalus propinquus / Q000737:chemistry; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D010065:Embryo Implantation, Delayed / Q000187:drug effects*; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D028183:Loranthaceae / Q000737:chemistry; D008297:Male; D051379:Mice; D015735:Mifepristone / Q000037:antagonists & inhibitors / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D027561:Salvia miltiorrhiza / Q000737:chemistry
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D015735:Mifepristone