Dynamics of the antibody-T. cruzi competition during Chagas infection: prognostic relevance of intracellular replication.
A recently proposed model for the competitive parasite-antibody interactions in Chagas disease is extended by separately describing the parasitic intracellular and extracellular phases. The model solutions faithfully reproduce available population data and yield predictions for parasite-induced cardiac cell damage.
Sibona
G J
GJ
Institute of Mathematics, University of Augsburg, Germany.
Condat
C A
CA
Cossy Isasi
S
S
D000222:Adaptation, Physiological / Q000276:immunology; D000818:Animals; D014355:Chagas Disease / Q000276:immunology* / Q000821:virology*; D003198:Computer Simulation; D018450:Disease Progression; D006790:Host-Parasite Interactions / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D018448:Models, Immunological; D011158:Population Growth; D011379:Prognosis; D012720:Severity of Illness Index; D014349:Trypanosoma cruzi / Q000254:growth & development* / Q000276:immunology* / Q000469:parasitology; D014779:Virus Replication / Q000276:immunology*