title: Synthesis of beta-lactam nucleoside chimera via Kinugasa reaction and evaluation of their antibacterial activity.
abstract: Several beta-lactam nucleoside chimeras 1 (cis) and 2 (trans) were synthesized from the corresponding N-propargyl nucleobases via Kinugasa reaction in moderate yields. Initial screening for antibacterial activity against ampicillin sensitive E. coli showed weak activity for the uracil-beta-lactam chimera.
authors.affiliation: Department of Chemistry, Indian Institute of Technology, Kharagpur 721302, India. absk@chem.iitkgp.ernet.in <absk@chem.iitkgp.ernet.in>
authors.forename: Amit
authors.initials: A
authors.lastname: Basak
authors.forename: Runa
authors.initials: R
authors.lastname: Pal
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D047090:beta-Lactams / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D009705:Nucleosides; D047090:beta-Lactams