[Non-ischemic neurological manifestations in patients with primary antiphospholipid syndrome].
Ischemic disorders of brain blood circulation caused by brain artery thrombosis due to antiphospholipids-induced anticoagulopathy are main neurological appearances of primary antiphospholipid syndrome (PAPS). A number of neurological disorders in patients with PAPS are the result of primary involvement of the brain and peripheral nervous system. We analyzed the spectrum of neurological non-ischemic PAPS manifestations in 125 patients (102 female, 23 male, mean age--37.5 +/- 11.3 years) with definite PAPS. These manifestations included headache (67%), epileptic seizures (23%), chorea (15%), optic neuropathy (9%), peripheral neuropathy (6%), multiple sclerosis like syndrome (MSLS) (8%), acute psychosis (2%), myasthenic syndrome (1%), non-vascular parkinsonism (1%). In the development of non-ischemic PAPS manifestations, antiphospholipids as well as other antibodies produced as a result of immune disregulation (antibodies to acetylcholine receptors in myasthenic syndrome, antineuronal antibodies in MSLS) may have pathogenic significance. In some cases a role of infection involved in PAPS manifestation cannot be ruled out.
Kalashnikova
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D000208:Acute Disease; D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000276:immunology; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D002819:Chorea / Q000209:etiology; D004827:Epilepsy / Q000209:etiology*; D005260:Female; D006261:Headache / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000209:etiology; D009157:Myasthenia Gravis / Q000209:etiology; D009422:Nervous System Diseases / Q000209:etiology*; D009901:Optic Nerve Diseases / Q000209:etiology; D020734:Parkinsonian Disorders / Q000209:etiology; D010523:Peripheral Nervous System Diseases / Q000209:etiology; D011618:Psychotic Disorders / Q000209:etiology*; D018860:Sneddon Syndrome / Q000209:etiology
D017152:Antibodies, Antiphospholipid