title: Informatics in radiology (infoRAD): new tools for computer assistance in thoracic CT. Part 1. Functional analysis of lungs, lung lobes, and bronchopulmonary segments.
abstract: Owing to the rapid development of scanner technology, thoracic computed tomography (CT) offers new possibilities but also faces enormous challenges with respect to the quality of computer-assisted diagnosis and therapy planning. In the framework of the Virtual Institute for Computer Assistance in Clinical Radiology cooperative research project, a prototypical software application was developed to assist the radiologist in functional analysis of thoracic CT data. By identifying the anatomic compartments of the lungs, the software application enables assessment of established functional CT parameters for each individual lung, pulmonary lobe, and pulmonary segment. Such region-based assessment allows a more localized diagnosis of lung diseases such as emphysema and more accurate estimation of regional lung function from CT data. With close cooperation between computer scientists and radiologists, the software application was tested and optimized to achieve a high degree of usability. Several clinical studies were carried out, the results of which indicated that the software application improves quantification in diagnosis, therapy planning, and therapy monitoring with respect to accuracy and time required.
authors.affiliation: MeVis Center for Medical Diagnostic Systems and Visualization, Universitaetsallee 29, 28359 Bremen, Germany. kuhnigk@mevis.de <kuhnigk@mevis.de>
authors.forename: Jan-Martin
authors.initials: JM
authors.lastname: Kuhnigk
authors.forename: Volker
authors.initials: V
authors.lastname: Dicken
authors.forename: Stephan
authors.initials: S
authors.lastname: Zidowitz
authors.forename: Lars
authors.initials: L
authors.lastname: Bornemann
authors.forename: Bernd
authors.initials: B
authors.lastname: Kuemmerlen
authors.forename: Stefan
authors.initials: S
authors.lastname: Krass
authors.forename: Heinz-Otto
authors.initials: HO
authors.lastname: Peitgen
authors.forename: Silja
authors.initials: S
authors.lastname: Yuval
authors.forename: Hans-Holger
authors.initials: HH
authors.lastname: Jend
authors.forename: Wigbert S
authors.initials: WS
authors.lastname: Rau
authors.forename: Tobias
authors.initials: T
authors.lastname: Achenbach
mesh_terms: D000465:Algorithms; D001980:Bronchi / Q000503:physiopathology*; D001995:Bronchography; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008171:Lung Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D011857:Radiographic Image Interpretation, Computer-Assisted; D013902:Radiography, Thoracic / Q000379:methods*; D012984:Software; D014057:Tomography, X-Ray Computed / Q000379:methods*