Expression of the carcinoembryonic antigen gene is inhibited by SOX9 in human colon carcinoma cells.
The human carcinoembryonic antigen (CEA) is overexpressed in many types of human cancers and is commonly used as a clinical marker. In colon cancer, this overexpression protects cells against apoptosis and contributes to carcinogenesis. Therefore, CEA-expressing cells as well as CEA expression itself constitute potential therapeutic targets. In this report, we show that the transcription factor SOX9 down-regulates CEA gene expression and, as a probable consequence, induces apoptosis in the human colon carcinoma cell line HT29Cl.16E.
Jay
Philippe
P
Institut de Génétique Humaine, Centre National de la Recherche Scientifique UPR1142, Montpellier, France.
Berta
Philippe
P
Blache
Philippe
P
D017209:Apoptosis / Q000502:physiology; D002272:Carcinoembryonic Antigen / Q000096:biosynthesis / Q000235:genetics*; D002454:Cell Differentiation / Q000502:physiology; D003110:Colonic Neoplasms / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D015536:Down-Regulation / Q000502:physiology; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D019073:HT29 Cells; D006609:High Mobility Group Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D006801:Humans; D011401:Promoter Regions, Genetic; D055758:SOX9 Transcription Factor; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*
D002272:Carcinoembryonic Antigen; D006609:High Mobility Group Proteins; D055758:SOX9 Transcription Factor; C527932:SOX9 protein, human; D014157:Transcription Factors