Scratch n' screen for inhibitors of cell migration.
Yarrow et al. have identified a small molecule inhibitor of cell migration, 3-(4-pyridyl)indole ("Rockout"), that targets Rho-kinase via a novel screening method using a scratch wound healing assay adapted to a high-throughput format and automated microscopy.
Soderholm
Jon
J
Molecular and Cell Biology Department, University of California, Berkeley 94720, USA.
Heald
Rebecca
R
D000818:Animals; D002464:Cell Migration Inhibition; D002465:Cell Movement / Q000187:drug effects*; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects
D007211:Indoles