title: T-cell lymphoblastic leukemia/lymphoma syndrome with eosinophilia and acute myeloid leukemia.
abstract: This case represents an example of an unusual T-cell lymphoblastic leukemia/lymphoma syndrome associated with eosinophilia and myeloid malignancy in a young boy. This case is one of only five reported "leukemic" variants of the disease and demonstrates the importance of considering this poor prognostic diagnosis in pediatric acute lymphoblastic leukemia. This case also illustrates the importance of an interactive multidisciplinary approach to the laboratory evaluation of a leukemia patient.
authors.affiliation: Department of Pediatrics, Division of Hematology and Oncology, University of South Carolina School of Medicine, Columbia, South Carolina, USA. lslamb@uambmc.edu
authors.forename: Lawrence S
authors.initials: LS
authors.lastname: Lamb
authors.forename: Ronnie
authors.initials: R
authors.lastname: Neuberg
authors.forename: Jeff
authors.initials: J
authors.lastname: Welsh
authors.forename: Robert
authors.initials: R
authors.lastname: Best
authors.forename: Maryalice
authors.initials: M
authors.lastname: Stetler-Stevenson
authors.forename: April
authors.initials: A
authors.lastname: Sorrell
mesh_terms: D000954:Antigens, Surface / Q000096:biosynthesis; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D002648:Child; D003582:Cytogenetics; D004802:Eosinophilia / Q000150:complications* / Q000628:therapy; D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000628:therapy; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications* / Q000628:therapy; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000150:complications* / Q000628:therapy; D008297:Male; D011379:Prognosis; D012074:Remission Induction; D013577:Syndrome
chemical_list: D000954:Antigens, Surface