title: Chemokine response in children with SARS.
abstract: The chemokine response of eight children with serologically confirmed severe acute respiratory syndrome (SARS) was longitudinally monitored. All had raised plasma interferon gamma inducible protein (IP-10) concentrations, which suggested an active type 1 T-helper lymphocyte mediated immune response. High circulating IP-10 levels could facilitate viral clearance and might play a role in assisting the recovery of the patients.
authors.affiliation: Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories. pakcheungng@cuhk.edu.hk
authors.forename: P C
authors.initials: PC
authors.lastname: Ng
authors.forename: C W K
authors.initials: CW
authors.lastname: Lam
authors.forename: A M
authors.initials: AM
authors.lastname: Li
authors.forename: C K
authors.initials: CK
authors.lastname: Wong
authors.forename: T F
authors.initials: TF
authors.lastname: Leung
authors.forename: F W T
authors.initials: FW
authors.lastname: Cheng
authors.forename: K L E
authors.initials: KL
authors.lastname: Hon
authors.forename: I H S
authors.initials: IH
authors.lastname: Chan
authors.forename: E
authors.initials: E
authors.lastname: Wong
authors.forename: T F
authors.initials: TF
authors.lastname: Fok
mesh_terms: D018932:Chemokine CCL2 / Q000378:metabolism; D018946:Chemokine CCL5 / Q000378:metabolism; D054357:Chemokine CXCL10; D054370:Chemokine CXCL9; D018925:Chemokines / Q000378:metabolism*; D019743:Chemokines, CXC / Q000378:metabolism; D002648:Child; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D007371:Interferon-gamma / Q000378:metabolism; D008137:Longitudinal Studies; D045169:Severe Acute Respiratory Syndrome / Q000097:blood*; D013601:T-Lymphocytes / Q000378:metabolism
chemical_list: C111835:CCL2 protein, human; C114753:CXCL10 protein, human; C080810:CXCL9 protein, human; D018932:Chemokine CCL2; D018946:Chemokine CCL5; D054357:Chemokine CXCL10; D054370:Chemokine CXCL9; D018925:Chemokines; D019743:Chemokines, CXC; D036341:Intercellular Signaling Peptides and Proteins; D007371:Interferon-gamma