title: Autonomic neuropathy may be associated with delayed orocaecal transit time in patients with cirrhosis.
abstract: Orocaecal transit (OCT) time is delayed in patients with cirrhosis, but the reasons for this remain unclear. We hypothesized that autonomic neuropathy (AN) may explain the delay in OCT.
  
  
  METHODS
  We determined OCT and autonomic function tests (AFT) in 48 patients (Child A-15, B-27, C-6) with cirrhosis of various aetiologies. AFT were categorized as normal, borderline, or abnormal. OCT was measured using the lactulose hydrogen (H2) breath test. OCT was defined as the time from baseline when there was a rise in H2 levels of >20 ppm over baseline or >10 ppm over baseline sustained over 2 consecutive time points.
  
  
  RESULTS
  Based on OCT, patients were separated into those with delayed OCT (>90 min, group I) and normal OCT (< or = 90 min, group II). Mean OCT time of patients in group I was 169.7+/-49.7 min vs. 84.4+/-12.1 min in group II. Baseline clinical characteristics of patients with and without AN, and those with normal and delayed OCT were similar. Presence of mild encephalopathy did not have an effect on OCT. AN was seen more frequently in group I than group II [16/32 (50%) vs. 3/16 (19%), p=0.03]. Logistic regression analysis showed that the presence of AN was the only independent variable associated with delayed OCT (OR 7.3, CI 1.3-39.4, p=0.02).
  
  
  CONCLUSIONS
  Our study showed that the presence of AN was associated with delayed OCT in patients with cirrhosis.
authors.affiliation: Division of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, 1830 E. Monument Street, suite 430, Baltimore, MD 21205, USA.
authors.forename: Anurag
authors.initials: A
authors.lastname: Maheshwari
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Thuluvath
mesh_terms: D000328:Adult; D001944:Breath Tests; D005260:Female; D005355:Fibrosis / Q000503:physiopathology*; D005772:Gastrointestinal Transit; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000032:analysis; D007792:Lactulose; D008111:Liver Function Tests; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000503:physiopathology*; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D007792:Lactulose