title: On the evolution of epistasis I: diploids under selection.
abstract: One interpretation of recent literature on the evolution of phenotypic modularity is that evolution should act to decrease the degree of interaction between genes that contribute to different phenotypes. This issue is addressed directly here using a fitness scheme determined by two genetic loci and a third locus which modifies a measure of statistical interaction between the fitnesses due to the first two. The equilibrium structure of such an epistasis-modifying locus is studied. It is shown that under well-specified conditions a modifying allele that increases epistasis succeeds. In other words, genetic interactions tend to become stronger. It is speculated that this occurs because the mean fitness in such models is locally increasing as a function of the degree of epistasis.
authors.affiliation: School of Mathematical Sciences, Tel Aviv University, Tel Aviv 69978, Israel. liberman@post.tau.ac.il
authors.forename: Uri
authors.initials: U
authors.lastname: Liberman
authors.forename: Marcus W
authors.initials: MW
authors.lastname: Feldman
mesh_terms: D004171:Diploidy; D004843:Epistasis, Genetic; D005787:Gene Frequency; D006801:Humans; D015233:Models, Statistical; D011110:Polymorphism, Genetic; D012641:Selection, Genetic