Fatigue induced by intermittent maximal voluntary contractions is associated with significant losses in muscle output but limited reductions in functional MRI-measured brain activation level.
The main purpose of this study was to characterize brain activation patterns during a fatigue task involving repetitive maximal voluntary contractions (MVC) of finger flexor muscles. Fourteen young, healthy human participants performed approximately 100 handgrip MVCs (each 2-s contraction was followed by a 1-s rest) while their brain was imaged by functional MRI (fMRI). The handgrip force and electromyograms (EMG) of the finger flexors declined progressively to about 40% of the initial values at the end of the fatigue task, suggesting that significant muscle fatigue had occurred. In contrast, the level of the fMRI signal in the primary (sensorimotor), secondary (supplementary motor), and association (prefrontal and cingulate) motor-function cortices did not change significantly throughout the fatigue task (although the signal of the primary sensorimotor cortex showed a clear trend of decline). The fMRI data from the task of intermittent handgrip MVCs differed dramatically from those obtained in a 2-min sustained handgrip MVC published in a recent report, in which the overall fMRI-measured brain activation level was substantially lower and followed an increase-then-decrease pattern compared to the linear decreases in force and EMG. These results support the notion that the motor cortical centers control the tasks of repetitive and continuous muscle contractions differently and that there is a decoupling in the signal changes of the brain and muscles during muscle fatigue processes induced by maximal voluntary contractions.
Liu
Jing Z
JZ
Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
Zhang
Luduan
L
Yao
Bing
B
Sahgal
Vinod
V
Yue
Guang H
GH
D004576:Electromyography / Q000379:methods; D005260:Female; D018737:Hand Strength / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009119:Muscle Contraction / Q000502:physiology*; D018763:Muscle Fatigue / Q000502:physiology*; D013003:Somatosensory Cortex / Q000502:physiology*