title: Facile one-pot synthesis of 2,3,5-substituted 1,2,4-oxadiazolines from nitriles in aqueous solution.
abstract: [reaction: see text] Alkyl/aryl amidoximes, prepared from the corresponding nitriles and N-alkylhydroxylamines, have readily undergone consecutive Michael additions to electron-deficient alkynes and provided highly substituted 1,2,4-oxadiazolines in good yields in homogeneous aqueous solution.
authors.affiliation: The Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06422, USA. narasimhulu.naidu@bms.com
authors.forename: B Narasimhulu
authors.initials: BN
authors.lastname: Naidu
authors.forename: Margaret E
authors.initials: ME
authors.lastname: Sorenson
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D010069:Oxadiazoles / Q000138:chemical synthesis*; D010091:Oximes / Q000138:chemical synthesis; D012996:Solutions; D014867:Water / Q000737:chemistry
chemical_list: D000480:Alkynes; D009570:Nitriles; D010069:Oxadiazoles; D010091:Oximes; D012996:Solutions; D014867:Water