title: Primary lung adenocarcinoma with heterotopic bone formation.
abstract: A 46-year-old man was referred to our hospital for the treatment of lung cancer. Computed tomography showed a well-defined tumor mass that was 50x45 mm in size and contained a trabecular pattern of calcification. Since he was diagnosed as having a primary lung adenocarcinoma (clinical stage IB), a left upper lobectomy with mediastinal lymph node dissection was performed. Histologically, the tumor was a poorly differentiated adenocarcinoma with rich fibrous stroma, in which there were island-shaped bone formation lesions. An immunohistochemical examination showed the expression of bone morphogenic protein-2 within tumor cells, which induce and stimulate bone formation. This finding may elucidate a possible mechanism of heterotopic bone formation.
authors.affiliation: Department of Thoracic Surgery, Nagoya University School of Medicine, Nagoya, Japan.
authors.forename: Noriyasu
authors.initials: N
authors.lastname: Usami
authors.forename: Hiromu
authors.initials: H
authors.lastname: Yoshioka
authors.forename: Shoichi
authors.initials: S
authors.lastname: Mori
authors.forename: Munehisa
authors.initials: M
authors.lastname: Imaizumi
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Nagasaka
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ueda
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D019485:Bone Morphogenetic Proteins / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000473:pathology*
chemical_list: D019485:Bone Morphogenetic Proteins