title: [Clinical investigation in the expression of matrix metalloproteinase 2 mRNA in the hyperplastic scar in burn patients].
abstract: OBJECTIVE
  To investigate the dynamic expression of matrix metalloproteinase 2 in the hyperplastic scar in burn patients.
  
  
  METHODS
  Twenty-three pieces of hyperplastic scar tissue samples were harvested from the patients with deep partial thickness burn wound during the early, middle and late periods after natural wound healing. In situ hybridization technique and positive cell percentage counting were employed to determine the expression and the distribution of MMP-2 mRNA in the scar tissue from different periods with that of the middle period as the control.
  
  
  RESULTS
  MMP-2 mRNA was mainly expressed in the fibroblasts in scar tissue. The positive percentage of MMP-2 in early period was 13.9 +/- 3.6%, and it increased thereafter, till it reached 68.7 +/- 5.2% in the middle period. However, it declined to 2.0 +/- 0.9% in the late period.
  
  
  CONCLUSIONS
  MMP-2 might be closely related to the process of scar tissue remodeling.
authors.affiliation: Department of Burns, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Yang
authors.forename: Duo
authors.initials: D
authors.lastname: Wei
authors.forename: Zhao-Fan
authors.initials: ZF
authors.lastname: Xia
mesh_terms: D000328:Adult; D002056:Burns / Q000150:complications / Q000378:metabolism*; D017439:Cicatrix, Hypertrophic / Q000209:etiology / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics; D014945:Wound Healing
chemical_list: D012333:RNA, Messenger; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2