Non-multifactorial neural tube defects.
Although most neural tube defects (anencephaly, spina bifida) occur as isolated malformations, a substantial proportion are attributable to chromosome anomalies, known teratogens, or component manifestations of multiple anomaly syndromes. This review describes known chromosome alterations and the candidate genes residing in the altered region, as well as syndromes associated with neural tube defects and causative genes, if known.
Lynch
Sally Ann
SA
National Centre for Medical Genetics, Our Lady's Hospital for Sick Children, Crumlin, Dublin, Ireland. Sally.lynch@ucd.ie
D000015:Abnormalities, Multiple / Q000235:genetics; D000818:Animals; D002869:Chromosome Aberrations; D020022:Genetic Predisposition to Disease; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009436:Neural Tube Defects / Q000235:genetics*; D012307:Risk Factors; D013577:Syndrome
D009419:Nerve Tissue Proteins