Biological gain of carbon-ion radiotherapy for the early response of tumor growth delay and against early response of skin reaction in mice.
The biological effectiveness of carbon ions relative to gamma rays (RBE) was compared between the tumor growth delay and an early skin reaction of syngeneic mice. The RBE was larger for a tumor than skin when irradiated with large doses of high-LET (linear energy transfer) carbon ions. The intra-track damage (a term of a linear quadratic model) of a tumor and skin increased equally with an increase of the LET, while the inter-track damage (beta term) of skin alone increased with the LET. These data provide evidence that high-LET radiotherapy could achieve therapeutic gain by minimizing the difference in response to fractionated irradiation between the tumor and normal tissue.
Ando
Koichi
K
Heavy-Ion Radiology Research Group, National Institute of Radiological Sciences, Chiba-shi, Chiba, Japan. ando@nirs.go.jp
Koike
Sachiko
S
Uzawa
Akiko
A
Takai
Nobuhiko
N
Fukawa
Takeshi
T
Furusawa
Yoshiya
Y
Aoki
Mizuho
M
Miyato
Yasuyuki
Y
D000818:Animals; D002247:Carbon Isotopes / Q000009:adverse effects* / Q000627:therapeutic use*; D049109:Cell Proliferation / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005354:Fibrosarcoma / Q000473:pathology* / Q000532:radiotherapy*; D005720:Gamma Rays / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D011855:Radiodermatitis / Q000209:etiology* / Q000473:pathology* / Q000517:prevention & control; D011879:Radiotherapy Dosage; D012867:Skin / Q000528:radiation effects*; D016896:Treatment Outcome
D002247:Carbon Isotopes