Yolk sac tumor of the vulva: a case report with long-term disease-free survival.
BACKGROUND
Yolk sac tumor (YST) of the vulva is extremely rare. Seven cases of vulvar YST have been reported to the literature. Due to the rarity of tumors, the appropriate choice of treatment may remain unclear.


METHODS
A 30-year-old woman presented with a 3.5-cm right labial mass. Excisional biopsy showed YST with predominant solid pattern. Three weeks after excision, right inguinal lymph node biopsy revealed metastatic tumor. The serum alpha-fetoprotein (AFP) was not elevated. Cisplatin-based chemotherapy was administered, followed by pelvic and groin irradiation. The patient was free of disease 90 months after the diagnosis.


CONCLUSIONS
Local excision of tumor with adjuvant cisplatin-based chemotherapy can be justified for vulvar YST. Inguinal lymphadenectomy is recommended because metastasis may occur early. Adjuvant radiation therapy may help to control the disease. Tumor size of 5 cm or less may be a favorable prognostic factor. Serum AFP level may not be a sensitive marker for follow-up of vulvar YST.
Khunamornpong
Surapan
S
Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand. skhunamo@mail.med.cmu.ac.th
Siriaunkgul
Sumalee
S
Suprasert
Prapaporn
P
Chitapanarux
Imjai
I
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D018572:Disease-Free Survival; D018240:Endodermal Sinus Tumor / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D011878:Radiotherapy; D014846:Vulvar Neoplasms / Q000473:pathology / Q000628:therapy*
D002945:Cisplatin