Genomic determinants of prognosis in colorectal cancer.
Colorectal cancer progression is characterized by the sequential acquisition of multiple genetic aberrations. Insights into the biology of cancer cell and the development of novel methodologies have open a new frontier in the search of independent molecular factors to better predict outcome. Besides the generation of a large list of candidate markers, their applicability in routine clinical settings has been hindered by the heterogeneity of the disease. The analysis of cumulated genetic damage offers a more comprehensive measure of the cancer cell's genomic disruption and appears as a gauge of malignant potential. The prognostic application of different determinants of genomic damage is reviewed.
Vendrell
Elisenda
E
IDIBELL-Institut de Recerca Oncològica, Hospital Duran i Reynals, Granvia km 2,7, L'Hospitalet, Barcelona 08907, Spain.
Morales
Cristina
C
Risques
Rosa-Ana
RA
Capellà
Gabriel
G
Peinado
Miguel A
MA
D014408:Biomarkers, Tumor; D002869:Chromosome Aberrations; D015179:Colorectal Neoplasms / Q000235:genetics*; D004249:DNA Damage; D018450:Disease Progression; D007621:Karyotyping; D009154:Mutation; D011379:Prognosis
D014408:Biomarkers, Tumor