Progressive supranuclear palsy-like phenotype associated with bilateral hypoxic-ischemic striopallidal lesions.
A progressive supranuclear palsy (PSP)-like syndrome due to vascular or anoxic brain insult is rare. We describe a 65-year-old man with a progressive PSP-like phenotype associated with hypoxic-ischemic bilateral striopallidal lesions, secondary to rupture of and subsequent surgery for a thoracic aortic aneurysm. After early extrapyramidal features, 10 months later he started to fall, and developed levator inhibition. A supranuclear gaze palsy for downgaze was documented 5.5 years after the insult.
Kim
Hee Tae
HT
National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.
Shields
Simon
S
Bhatia
Kailash P
KP
Quinn
Niall
N
D000368:Aged; D003342:Corpus Striatum / Q000473:pathology*; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000150:complications* / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D013494:Supranuclear Palsy, Progressive / Q000150:complications* / Q000473:pathology*