title: Protective effects of cisternal irrigation on leptomeningeal and cortical structures in meningitis: an experimental study.
abstract: BACKGROUND
  Meningitis, termed as foreign material collection in the subarachnoid space, leads to various meningeal, cerebral and spinal cord pathologies. Meningitis still remains a problematic disease with severe complications in spite of advanced medical technology.
  
  
  OBJECTIVE
  In this study, we aimed to investigate the role of cisternal irrigation in the prevention of meningitis complications. SETTING AND STUDY DESIGN: Experimental study was done in the Social Security Hospital of Erzurum. Histopathological specimens were evaluated in the Pathology Department in the Ataturk University Research Hospital, Erzurum, Turkey.
  
  
  METHODS
  This study was conducted on twelve lambs. Experimental meningitis was achieved with streptococcus pneumonia. Two animals were not treated. Ten animals were given Cefotaxime (4 x 1g/day) for 20 days, and additionally half of these animals underwent cisternal irrigation. Then, all animals were sacrificed and brains were observed histopathologically.
  
  
  RESULTS
  Massive purulent CSF formation, hemorrhagic cortical lesions, vascular congestion, leptomeningeal and cortical adhesions and brain edema were observed in the non-irrigated group, but these findings were observed slightly or absent in the irrigated group.
  
  
  CONCLUSIONS
  Meningitis can affect all central neural tissues, consequently serious central nervous system lesions may develop. The irrigation procedure may decrease the percentage and severity of meningitis complications by way of the excretion of inflamed purulent collection from the subarachnoid spaces.
authors.affiliation: Department of Neurosurgery, Medical School of Ataturk University, Erzurum, Turkey. naydin@atauni.edu.tr
authors.forename: M D
authors.initials: MD
authors.lastname: Aydin
authors.forename: C
authors.initials: C
authors.lastname: Gündogdu
authors.forename: F
authors.initials: F
authors.lastname: Akçay
authors.forename: N
authors.initials: N
authors.lastname: Gursan
mesh_terms: D000818:Animals; D002404:Catheterization; D002555:Cerebrospinal Fluid / Q000382:microbiology; D002946:Cisterna Magna / Q000382:microbiology*; D008586:Meningitis, Pneumococcal / Q000134:cerebrospinal fluid* / Q000628:therapy*; D012756:Sheep; D007507:Therapeutic Irrigation / Q000379:methods*