[The level of cotinine in urine and placenta of women smoking or exposure to tobacco smoke during pregnancy].
The aim of the studies was evaluation smoking habit by delivering woman using objective method--determination of cotinine in urine and placenta. In the study participated 93 woman delivering in Gynaecological-Obstetric Clinical Hospital of Medical University at Warsaw. Evaluation of tobacco smoking and exposure to ETS performed on the base of questionnaire and level of cotinine in urine. In the group of non smoking woman cotinine was not detected any in urine any in placenta. In the second group (19 patients), woman exposure to ETS concentration of cotinine in urine was 28.9 +/- 14.9 ng/mg of creatinine and only in two placentas was detected a low level of cotinine. In smoking delivering woman the urine concentration was 837.0 +/- 1324.5 ng/mg of creatinine and 21.3 +/- 7.5 ng/g placenta calculated from all results and 67.0 +/- 3.5 ng/g calculated only from positive results. A weak relation between concentration of cotinine in placenta and urine of smoking woman was shown.
Florek
Ewa
E
Laboratorium Badań Srodowiskowych Katedry i Zakładu Toksykologii Akademii Medycznej w Poznaniu. eflorek@amp.edu.pl
Kornacka
Maria K
MK
Hubert
Agnieszka
A
Wilimowska
Jolanta
J
Basior
Aneta
A
D000328:Adult; D015415:Biomarkers / Q000378:metabolism / Q000652:urine; D003367:Cotinine / Q000378:metabolism* / Q000652:urine; D005260:Female; D006801:Humans; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D012907:Smoking / Q000378:metabolism* / Q000652:urine; D011795:Surveys and Questionnaires; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
D015415:Biomarkers; D014028:Tobacco Smoke Pollution; D003367:Cotinine