title: [Choline- and histaminergic shifts as a trigger of gastroduodenal erosive-ulcer lesions in myocardial infarction].
abstract: OBJECTIVE
  To clarify the role of cholin- and histaminergic shifts in the onset of circulatory and functional gastric disturbances associated with erosive-ulcer gastroduodenal lesions in myocardial infarction (MI).
  
  
  METHODS
  Cholin- and histamine-reactive systems, end gastroduodenal mucosal circulation were studied in 80 Ml patients with gastroduodenal erosions and ulcers divided into three groups by the disease severity.
  
  
  RESULTS
  MI features influence characteristics and severity of gastroduodenal erosions and ulcers. The latter develop due to focal microcirculatory disorders in gastric and duodenal mucosa by thrombohemorrhagic or thromboischemic type. Moderate and severe coronary pathology is associated with higher production of hydrochloric acid and pepsinogen, with depressed production of gastromucoproteins, hypo- or hypermotor dyskinesia, extremely severe coronary pathology--with decline of all gastric functions except normal acid production. Erosive-ulcer lesions may be triggered by alterations in cholin-histamine systems the activity of which in moderately severe and severe MI rises but in extremely severe--lowers.
  
  
  CONCLUSIONS
  Pathogenesis of erosive-ulcer lesions of the gastroduodenal zone in MI has some specific features dependent on severity of MI. This should be taken in consideration in choice of drug therapy.
authors.forename: V V
authors.initials: VV
authors.lastname: Chernin
authors.forename: V A
authors.initials: VA
authors.lastname: Osadchiĭ
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002794:Choline / Q000097:blood*; D018450:Disease Progression; D005260:Female; D006632:Histamine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000453:epidemiology; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D010437:Peptic Ulcer / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism
chemical_list: D006632:Histamine; D002794:Choline