title: Results of a multicenter clinical trial to evaluate the preferential hyperacuity perimeter for detection of age-related macular degeneration.
abstract: OBJECTIVE
  To compare the preferential hyperacuity perimeter (PHP) with an Amsler grid in detection of age-related macular degeneration (AMD).
  
  
  METHODS
  Patients underwent refraction, visual acuity examination, PHP, Amsler grid examination, and macular photography.
  
  
  RESULTS
  One hundred fifty patients participated in the trial. Of 19 eyes with neovascular AMD, 19 (100%) were positive on the PHP, and 10 (53%), on the Amsler grid. Of 27 eyes with geographic atrophy, 26 (96%) were positive on the PHP, and 12 (44%), on the Amsler grid. Of 20 eyes with intermediate AMD, 14 (70%) were positive on the PHP, and 4 (20%), on the Amsler grid. Of 51 eyes with early AMD, 21 (41%) were positive on the PHP, and 4 (8%), on the Amsler grid. Of 33 eyes with no AMD, 6 (18%) were positive on the PHP, and none, on the Amsler grid. Thus, 80 (68%) of 117 patients with AMD had a positive PHP, while 30 (26%) had positive results of Amsler grid examination (P < 0.001, McNemar test).
  
  
  CONCLUSIONS
  The PHP had greater sensitivity, although with a relatively high rate of false-positive results for healthy individuals, than the Amsler grid in detecting AMD-related lesions.
authors.affiliation: Department of Ophthalmology, Tel-Aviv Medical Center, Israel.
authors.forename: Michaela
authors.initials: M
authors.lastname: Goldstein
authors.forename: Anat
authors.initials: A
authors.lastname: Loewenstein
authors.forename: Adiel
authors.initials: A
authors.lastname: Barak
authors.forename: Ayala
authors.initials: A
authors.lastname: Pollack
authors.forename: Amir
authors.initials: A
authors.lastname: Bukelman
authors.forename: Haia
authors.initials: H
authors.lastname: Katz
authors.forename: Amira
authors.initials: A
authors.lastname: Springer
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Schachat
authors.forename: Neil M
authors.initials: NM
authors.lastname: Bressler
authors.forename: Susan B
authors.initials: SB
authors.lastname: Bressler
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Cooney
authors.forename: Yair
authors.initials: Y
authors.lastname: Alster
authors.forename: Omer
authors.initials: O
authors.lastname: Rafaeli
authors.forename: Rafael
authors.initials: R
authors.lastname: Malach
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D010781:Photography / Q000379:methods; D011237:Predictive Value of Tests; D012029:Refraction, Ocular; D012680:Sensitivity and Specificity; D014792:Visual Acuity; D058609:Visual Field Tests / Q000379:methods*