Decrease of Lewis frequency in HIV-infected patients: possible competition of fucosylated antigens with HIV for binding to DC-SIGN.
We explored the impact of human ABO glycosyltransferase and Lewis and secretor fucosyltransferase polymorphisms in HIV infection. We found that, compared with healthy blood donors, HIV-infected patients display a significant decrease in Le(a-b+) phenotype frequencies. We showed that HIV binding on DC-SIGN-transduced Jurkat cells was inhibited by fucosyl bovine serum albumin. Our results suggest a slight protective effect of Lewis b antigen on HIV infection, possibly by the competition of Lewis antigens with HIV for binding to DC-SIGN.
Puissant
Bénédicte
B
Laboratoire d'Immunogénétique Moléculaire, Université Paul Sabatier, Faculté de médecine Toulouse-Rangueil, Toulouse, France.
Roubinet
Francis
F
Dellacasagrande
Jérôme
J
Massip
Patrice
P
Abbal
Michel
M
Pasquier
Christophe
C
Izopet
Jacques
J
Blancher
Antoine
A
D015815:Cell Adhesion Molecules / Q000378:metabolism*; D005647:Fucosyltransferases / Q000235:genetics*; D015658:HIV Infections / Q000097:blood* / Q000235:genetics; D006801:Humans; D019169:Jurkat Cells / Q000378:metabolism; D037181:Lectins, C-Type / Q000378:metabolism*; D007983:Lewis Blood Group Antigens / Q000235:genetics*; D010641:Phenotype; D012367:RNA, Viral / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012709:Serum Albumin / Q000378:metabolism; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
D015815:Cell Adhesion Molecules; D005647:Fucosyltransferases; D037181:Lectins, C-Type; D007983:Lewis Blood Group Antigens; D012367:RNA, Viral; D011956:Receptors, Cell Surface; D012709:Serum Albumin; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin