title: Evidence for yeast autophagy during simulation of sparkling wine aging: a reappraisal of the mechanism of yeast autolysis in wine.
abstract: Yeast autolysis is the source of several molecules responsible for the quality of wines aged in contact with yeast cells. However, the mechanisms of yeast autolysis during wine aging are not completely understood. All descriptions of yeast autolysis in enological conditions emphasize the disturbance of cell organization as the starting event in the internal digestion of the cell, while no reference to autophagy is found in wine-related literature. By using yeast mutants defective in the autophagic or the Cvt pathways we have demonstrated that autophagy does take place in wine production conditions. This finding has implications for the genetic improvement of yeasts for accelerated autolysis.
authors.affiliation: Instituto de Fermentaciones Industriales (CSIC), Juan de la Cierva, 3. 28006 Madrid, Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Cebollero
authors.forename: Alfonso V
authors.initials: AV
authors.lastname: Carrascosa
authors.forename: Ramon
authors.initials: R
authors.lastname: Gonzalez
mesh_terms: D001343:Autophagy; D015153:Blotting, Western; D005285:Fermentation; D012441:Saccharomyces cerevisiae / Q000502:physiology*; D014920:Wine