Using proteomics to identify potential therapeutic targets in platelets.
Proteomics has provided powerful new insights into the complex events of the anucleate platelet and has revealed many potential protein targets in the search for suitable agents for thrombotic disease. In the present study, we summarize recent proteomic approaches to analyse specific platelet subproteomes, such as the platelet releasate, the platelet phosphotyrosine proteome and characterization of the proteins associated with membrane lipid rafts.
Maguire
P B
PB
Department of Molecular Medicine, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland. patricia.maguire@ucd.ie
Foy
M
M
Fitzgerald
D J
DJ
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D006801:Humans; D021962:Membrane Microdomains / Q000737:chemistry / Q000378:metabolism; D019000:Phosphotyrosine / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D020543:Proteome; D040901:Proteomics
D020543:Proteome; D019000:Phosphotyrosine; D011505:Protein-Tyrosine Kinases