title: [Influence of sex on the prognosis of high risk acute coronary syndromes treated by early angioplasty].
abstract: The aim of this study was to evaluate the influence of sex on the prognosis of high risk acute coronary syndromes treated early with angioplasty. Over a period of two years, 694 consecutive patients (151 female, 543 male) underwent revascularisation within the first 24 hours of an acute coronary syndrome without permanent ST elevation (ST depression (52.5%) or relapse of angina despite medical treatment (47.5%). The females were older than the males (67.9 vs 62.3 years; p < 0.0001), smoked less (7.3 vs. 32.8%; p < 0.001) and had a higher prevalence of hypertension (53 vs. 42.1%; p = 0.017). The angiographic characteristics were equivalent in both sexes, except for a lower frequency of thrombus in the females (6.9 vs. 15.2%; p < 0.0001). All lesions were treated with endoprosthesis implantation. The angiographic success rate was comparable (94 vs. 93.7%) as was the rate of major cardiac events while in hospital (3.8 versus 4%). With an average survival of 2 years, the incidence of major cardiac events remained identical in both sexes (15.4 vs 15.7%: p = 0.43): cardiac mortality (3.2 vs 2%; p = 0.18), myocardial infarction (7.3 vs 6.7%; p = 0.37), further revascularisation (8.3 vs 7.2%; p = 0.47). The survival without major cardiac event was comparable at 1 year (87 +/- 0.1 vs 88 +/- 0.3%) and at 2 years (78 +/- 0.2 vs 83 +/- 0.3%; p = 0.58). In conclusion, the progression both in hospital and at two years with a strategy of early revascularisation for high risk acute coronary syndromes was comparable in males and females.
authors.affiliation: Unité de Cardiologie Interventionnelle, Clinique Pasteur, Lombez, Toulouse.
authors.forename: N
authors.initials: N
authors.lastname: Durel
authors.forename: D
authors.initials: D
authors.lastname: Zanuttini
authors.forename: M
authors.initials: M
authors.lastname: Loutfi
authors.forename: L
authors.initials: L
authors.lastname: Bonfils
authors.forename: B
authors.initials: B
authors.lastname: Farah
authors.forename: J
authors.initials: J
authors.lastname: Fajadet
authors.forename: J P
authors.initials: JP
authors.lastname: Bounhoure
authors.forename: J
authors.initials: J
authors.lastname: Marco
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000453:epidemiology / Q000628:therapy*; D001807:Blood Vessel Prosthesis; D017023:Coronary Angiography; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology / Q000628:therapy*; D009204:Myocardial Revascularization; D011379:Prognosis; D012189:Retrospective Studies; D012737:Sex Factors; D012907:Smoking / Q000453:epidemiology; D016019:Survival Analysis; D013927:Thrombosis / Q000453:epidemiology