title: Presence of tetracycline resistance determinants and susceptibility to tigecycline and minocycline.
abstract: No relation between the presence of tetracycline resistance determinants tet(A) to tet(E) and the MICs of tigecycline was observed for Enterobacteriaceae, although tetracycline-susceptible isolates were more susceptible overall to tigecycline, whereas the presence of tet(M) in Staphylococcus aureus was associated with higher MICs of minocycline.
authors.affiliation: Eijkman-Winkler Institute, University Medical Center Utrecht, Room G04.614, P.O. Box 85500, 3508 GA Utrecht, The Netherlands. A.C.Fluit@lab.azu.nl
authors.forename: Ad C
authors.initials: AC
authors.lastname: Fluit
authors.forename: Alice
authors.initials: A
authors.lastname: Florijn
authors.forename: Jan
authors.initials: J
authors.lastname: Verhoef
authors.forename: Dana
authors.initials: D
authors.lastname: Milatovic
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D004755:Enterobacteriaceae / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects; D013752:Tetracycline / Q000494:pharmacology; D013753:Tetracycline Resistance / Q000235:genetics; D000078304:Tigecycline
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D000078304:Tigecycline; D013752:Tetracycline; D008911:Minocycline