[The rhythm-modulant effect of lithium hydroxybutyrate on the background of electrolytic lesion of the right suprachiasmatic nucleus of hypothalamus].
Experimental lesion of the right suprachiasmatic nucleus of hypothalamus in rats facilitates manifestations of the free-running locomotor rhythm in winter solstice, but decreases the entrainment of the light cycle of this rhythm in the period of summer solstice. The administration of lithium hydroxybutyrate in both illumination regimes compensates the influence of lesion of the right suprachiasmatic nucleus. Features of the observed effect depend on the circadian phase of drug administration.
Zamoshchina
T A
TA
Meleshko
M V
MV
D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects*; D006885:Hydroxybutyrates / Q000008:administration & dosage*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009942:Organometallic Compounds / Q000008:administration & dosage*; D051381:Rats; D013493:Suprachiasmatic Nucleus / Q000502:physiology*
D006885:Hydroxybutyrates; D009942:Organometallic Compounds; C022826:lithium hydroxybutyrate