title: [Effect of some imidazole-4,5-dicarboxylic acid derivatives on the activity of N-methyl-D-aspartate (NMDA) receptors].
abstract: The results of experiments on mice showed that some imidazole-4,5-dicarboxylic acid derivatives injected into lateral cerebral ventricles produce a dose-dependent convulsant or anticonvulsant effects, that is, possess the properties of partial NMDA receptor agonists. The most promising partial NMDA receptor agonist selected for further investigation is 2-propylimidazole-4,5-dicarboxylic acid.
authors.forename: O M
authors.initials: OM
authors.lastname: Efremov
authors.forename: I Ia
authors.initials: IIa
authors.lastname: Aleksandrova
authors.forename: S V
authors.initials: SV
authors.lastname: Kulikov
authors.forename: N A
authors.initials: NA
authors.lastname: Losev
authors.forename: L B
authors.initials: LB
authors.lastname: Piotrovskiĭ
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage*; D002531:Cerebellum / Q000378:metabolism*; D003292:Convulsants / Q000008:administration & dosage*; D003998:Dicarboxylic Acids / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D007093:Imidazoles / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists* / Q000378:metabolism
chemical_list: D000927:Anticonvulsants; D003292:Convulsants; D003998:Dicarboxylic Acids; D007093:Imidazoles; D016194:Receptors, N-Methyl-D-Aspartate