title: 2'-Amino-alpha-chloroacetophenone as a valuable tool for the synthesis of conveniently-substituted alpha,beta-epoxychalcone derivatives.
abstract: The synthesis of conveniently substituted 2'-amino-alpha,beta-epoxychalcones is described. They were obtained through Darzens condensation of 2'-amino-3',5'-dimethoxy-alpha-chloroacetophenone with benzaldehydes. The latter can undergo different cyclization possibilities and afford a variety of flavonoid analogs with biological potential.
authors.affiliation: Département de Pharmacochimie Moléculaire, UMR CNRS-UJF 5063. Faculté de Pharmacie de Grenoble, France.
authors.forename: Madeleine
authors.initials: M
authors.lastname: Blanc
authors.forename: Maud
authors.initials: M
authors.lastname: Martin
authors.forename: Sabrina
authors.initials: S
authors.lastname: Okombi
authors.forename: Ahcène
authors.initials: A
authors.lastname: Boumendjel
mesh_terms: D000096:Acetone; D000098:Acetophenones / Q000138:chemical synthesis*; D001547:Benzaldehydes / Q000737:chemistry; D047188:Chalcones / Q000138:chemical synthesis*; D003500:Cyclization; D005419:Flavonoids / Q000138:chemical synthesis; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy
chemical_list: C502176:2'-amino-alpha-chloroacetophenone; D000098:Acetophenones; D001547:Benzaldehydes; D047188:Chalcones; D005419:Flavonoids; D007202:Indicators and Reagents; D000096:Acetone