Antiulcerogenic effect of Justicia prostrata Gamble.
Antiulcerogenic effect of the alcoholic (ALJP) and aqueous (AQJP) extracts of the whole plant of Justicia prostrata was studied in aspirin+pylorus ligated rat models and analysed for gastric volume, ulcer index, free and total acidity. Biochemical parameters like total proteins, total hexoses, hexosamine, fucose and sialic acid were also estimated. Both extracts (ALJP and AQJP) significantly reduced both the gastric volume and the acidity of gastric juice. It also significantly promoted gastric mucus secretion by increasing total carbohydrates and decreasing the protein concentration in aspirin+ pylorus ligated rats. The results suggest that both the extracts (ALJP and AQJP) possess antiulcer activity, whereas AQJP is more effective when compared with ALJP in aspirin+pylorus ligated rat models. The results were compared with the standard drug Rantidine, a H2 receptor antagonist.
Sanmugapriya
E
E
Department of Pharmacology & Environmental Toxicology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600 113, India.
Shanmugasundaram
P
P
Venkataraman
S
S
D027901:Acanthaceae / Q000737:chemistry*; D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001241:Aspirin; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000737:chemistry* / Q000378:metabolism; D005752:Gastric Mucins / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008026:Ligation; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology
D000897:Anti-Ulcer Agents; D005752:Gastric Mucins; D010936:Plant Extracts; D001241:Aspirin