Bilateral testicular enlargement and seminoma in a patient with acromegaly.
Growth hormone (GH) excess has been associated with soft tissue changes and an increase in the incidence of colonic polyps and gastrointestinal cancer. We describe a patient with endogenous GH excess caused by a pituitary tumour, resulting in acromegaly. The patient had bilateral testicular enlargement, with tumour of the right testicle. Pituitary MRI revealed a macroadenoma. After resection of the pituitary tumour, GH levels fell below 0.5 ng/ml, with acromegaly resolution. Testicular resection revealed seminoma. Following acromegaly resolution, the enlarged remaining testicle decreased in size. The implications of the testicular enlargement and seminoma in the presence of a GH-secreting tumour are discussed.
Abraham
D
D
Division of Endocrinology & Metabolism, Department of Internal Medicine, University of Utah, Salt Lake City 84132, USA.
Couldwell
W T
WT
D000172:Acromegaly / Q000150:complications*; D000239:Adenoma, Acidophil / Q000150:complications; D000328:Adult; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010911:Pituitary Neoplasms / Q000150:complications; D018239:Seminoma / Q000209:etiology*; D013736:Testicular Neoplasms / Q000209:etiology*
D019382:Human Growth Hormone