Human immunodeficiency virus gp120 downregulates CD1d cell surface expression.
CD1d is an MHC class I-like surface molecule that presents endogenous glycoplipid antigens. The effect of HIV infection on CD1d surface expression has not yet been reported. FACS analysis revealed significantly lower levels of CD1d on CD14(+) monocytes from HIV-infected subjects compared to HIV-infected subjects on HAART and healthy controls. CD1d expression correlated inversely with viral load in infected individuals. CD1d surface expression on human cell lines was downregulated after infection with M-tropic HIV, T-tropic HIV, or after exposure to HIV gp120 in vitro. These data suggest that CD1d-mediated responses are altered during HIV infection and may thus contribute to the global immunodeficiency seen in these patients.
Hage
Chadi A
CA
Indiana University School of Medicine, Indianapolis, IN, USA.
Kohli
Lisa L
LL
Cho
Sungyoo
S
Brutkiewicz
Randy R
RR
Twigg
Homer L
HL
Knox
Kenneth S
KS
D018949:Antigens, CD1 / Q000096:biosynthesis / Q000235:genetics*; D055610:Antigens, CD1d; D001681:Biological Assay; D015536:Down-Regulation; D015699:HIV Envelope Protein gp120 / Q000276:immunology / Q000378:metabolism*; D015497:HIV-1 / Q000276:immunology / Q000378:metabolism; D006801:Humans; D019169:Jurkat Cells; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism*; D016131:Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D020298:U937 Cells
D018949:Antigens, CD1; D055610:Antigens, CD1d; C526877:CD1D protein, human; D015699:HIV Envelope Protein gp120