title: Heavy particle irradiation, neurochemistry and behavior: thresholds, dose-response curves and recovery of function.
abstract: Exposure to heavy particles can affect the functioning of the central nervous system (CNS), particularly the dopaminergic system. In turn, the radiation-induced disruption of dopaminergic function affects a variety of behaviors that are dependent upon the integrity of this system, including motor behavior (upper body strength), amphetamine (dopamine)-mediated taste aversion learning, and operant conditioning (fixed-ratio bar pressing). Although the relationships between heavy particle irradiation and the effects of exposure depend, to some extent, upon the specific behavioral or neurochemical endpoint under consideration, a review of the available research leads to the hypothesis that the endpoints mediated by the CNS have certain characteristics in common. These include: (1) a threshold, below which there is no apparent effect; (2) the lack of a dose-response relationship, or an extremely steep dose-response curve, depending on the particular endpoint; and (3) the absence of recovery of function, such that the heavy particle-induced behavioral and neural changes are present when tested up to one year following exposure. The current report reviews the data relevant to the degree to which these characteristics are common to neurochemical and behavioral endpoints that are mediated by the effects of exposure to heavy particles on CNS activity.
authors.affiliation: Department of Psychology, University of Maryland Baltimore County, Baltimore, MD 21250, USA. rabin@umbc.edu
authors.forename: B M
authors.initials: BM
authors.lastname: Rabin
authors.forename: J A
authors.initials: JA
authors.lastname: Joseph
authors.forename: B
authors.initials: B
authors.lastname: Shukitt-Hale
mesh_terms: D000661:Amphetamine / Q000528:radiation effects; D000818:Animals; D001362:Avoidance Learning / Q000528:radiation effects; D001522:Behavior, Animal / Q000528:radiation effects*; D002490:Central Nervous System / Q000528:radiation effects*; D000697:Central Nervous System Stimulants / Q000528:radiation effects; D003213:Conditioning, Psychological / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D020450:Heavy Ions; D009043:Motor Activity / Q000528:radiation effects; D009424:Nervous System Physiological Phenomena / Q000528:radiation effects*; D009448:Neurochemistry; D051381:Rats; D020127:Recovery of Function / Q000528:radiation effects; D012062:Relative Biological Effectiveness; D013649:Taste / Q000528:radiation effects
chemical_list: D000697:Central Nervous System Stimulants; D000661:Amphetamine