Super pH-sensitive multifunctional polymeric micelle.
To endow enhanced tumor specificity and endosome disruption property on the carrier, a multifunctional polymeric micelle was investigated. The micelle exposes the cell interacting ligand (biotin) on the surface under slightly acidic environmental conditions of various solid tumors and is internalized by biotin receptor-mediated endocytosis in a short time period. The micelle also showed pH-dependent dissociation, causing the enhanced release of doxorubicin from the carrier in early endosomal pH. The dissociated micellar components subsequently disrupt endosomal membrane.
Lee
Eun Seong
ES
Department of Pharmaceutics and Pharmaceutical Chemistry, The University of Utah, 421 Wakara Way, Salt Lake City, Utah 84108.
Na
Kun
K
Bae
You Han
YH
D000230:Adenocarcinoma / Q000737:chemistry* / Q000473:pathology*; D001710:Biotin / Q000737:chemistry*; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology; D045744:Cell Line, Tumor; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000737:chemistry*; D008422:Materials Testing; D049329:Nanostructures / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*
D020099:Coated Materials, Biocompatible; D007773:Lactates; C088513:poly(lactic acid-ethylene glycol); D011092:Polyethylene Glycols; D001710:Biotin