Anti-estrogenic activity of lignans from Acanthopanax chiisanensis root.
Anti-estrogenic activity of (-)-sesamin (1), helioxanthin (2), savinin (3), taiwanin C (4), and 3-(3,4-dimethoxybenzyl)-2-(3,4-methylenedioxybenzyl)butyrolactone (5) isolated from the root of Acanthopanax chiisanensis was tested using Ishikawa cells. Among them, compound 3 exhibited anti-estrogenic activity (IC50 = 4.86 microM).
Lee
Sanghyun
S
College of Pharmacy, Seoul National University, Seoul 151-742, Korea. jnp@korea.com
Yoo
Hye Hyun
HH
Piao
Xiang Lan
XL
Kim
Ju Sun
JS
Kang
Sam Sik
SS
Shin
Kuk Hyun
KH
D000251:Adenosine Triphosphatases / Q000096:biosynthesis; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D028001:Eleutherococcus / Q000737:chemistry*; D004790:Enzyme Induction / Q000187:drug effects; D004965:Estrogen Antagonists / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D006801:Humans; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D048789:Phytoestrogens / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013778:Tetrazolium Salts; D013844:Thiazoles
D000972:Antineoplastic Agents, Phytogenic; D004965:Estrogen Antagonists; D017705:Lignans; D048789:Phytoestrogens; D013778:Tetrazolium Salts; D013844:Thiazoles; D000251:Adenosine Triphosphatases; C022616:thiazolyl blue