title: Analysis of the RB1 gene in children with retinoblastoma having residential connections to West Cumbria, England.
abstract: Six of eight cases of retinoblastoma previously identified as having a residential association with West Cumbria, England, in which the Sellafield nuclear installation is situated, were examined for the presence of a constitutional RB1 mutation. No mutations were detected, thus providing strong evidence against an environmental or occupational genotoxic effect causing germline mutations in the parents of these children.
authors.affiliation: Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
authors.forename: J K
authors.initials: JK
authors.lastname: Cowell
authors.forename: J A
authors.initials: JA
authors.lastname: Morris
authors.forename: E J
authors.initials: EJ
authors.lastname: Tawn
mesh_terms: D002675:Child, Preschool; D004739:England / Q000453:epidemiology; D005260:Female; D016161:Genes, Retinoblastoma / Q000235:genetics*; D018095:Germ-Line Mutation / Q000235:genetics; D006801:Humans; D007223:Infant; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology* / Q000235:genetics*; D009688:Nuclear Reactors; D012111:Residence Characteristics; D012175:Retinoblastoma / Q000453:epidemiology* / Q000235:genetics*