title: Effects of high linear energy transfer radiation on the cochlea of C3H/He mouse during postnatal developmental course.
abstract: To investigate the biological effectiveness of neutrons at energies below 1MeV with regard to ear toxicity, we exposed mice to 1.0 Gy of monoenergetic neutrons (1.026 MeV) or 137Cs gamma rays at 7 days of age, and observed subsequent morphological changes in the inner ear with light and scanning electron microscopes. Monoenergetic neutrons, but not gamma rays, caused acute changes in the ear. The epithelium of the greater epithelial ridge in the organ of Corti showed degeneration around 6 hours and disappeared by 72 hours post-irradiation. The apoptotic cell death of the epithelium of the greater epithelial ridge was inducible by the radiation at 3 or 4 days of age. The hair cells formed the protrusion structures of the surface by 72 hours post-irradiation. Neutron-irradiation also caused acute otitis media until 10 weeks of age.
authors.affiliation: International Radiation Information Center, Research Institute for Radiation Biology and Medicine, Hiroshima University, Kasumi, Hiroshima, Japan. yumiko@hiroshima-u.ac.jp
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Nitta
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Araki
authors.forename: Kohsaku
authors.initials: K
authors.lastname: Nitta
authors.forename: Toshihide
authors.initials: T
authors.lastname: Harada
authors.forename: Fumiko
authors.initials: F
authors.lastname: Ishizaki
authors.forename: Juko
authors.initials: J
authors.lastname: Ando
mesh_terms: D000375:Aging / Q000473:pathology / Q000528:radiation effects*; D000818:Animals; D000831:Animals, Newborn; D017209:Apoptosis / Q000528:radiation effects; D003051:Cochlea / Q000473:pathology* / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D018499:Linear Energy Transfer; D051379:Mice; D008809:Mice, Inbred C3H; D009502:Neutrons / Q000009:adverse effects*; D010033:Otitis Media / Q000209:etiology* / Q000473:pathology*; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000209:etiology / Q000473:pathology*