Primary lung adenocarcinoma with heterotopic bone formation.
A 46-year-old man was referred to our hospital for the treatment of lung cancer. Computed tomography showed a well-defined tumor mass that was 50x45 mm in size and contained a trabecular pattern of calcification. Since he was diagnosed as having a primary lung adenocarcinoma (clinical stage IB), a left upper lobectomy with mediastinal lymph node dissection was performed. Histologically, the tumor was a poorly differentiated adenocarcinoma with rich fibrous stroma, in which there were island-shaped bone formation lesions. An immunohistochemical examination showed the expression of bone morphogenic protein-2 within tumor cells, which induce and stimulate bone formation. This finding may elucidate a possible mechanism of heterotopic bone formation.
Usami
Noriyasu
N
Department of Thoracic Surgery, Nagoya University School of Medicine, Nagoya, Japan.
Yoshioka
Hiromu
H
Mori
Shoichi
S
Imaizumi
Munehisa
M
Nagasaka
Tetsuro
T
Ueda
Yuichi
Y
D000230:Adenocarcinoma / Q000473:pathology*; D019485:Bone Morphogenetic Proteins / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000473:pathology*
D019485:Bone Morphogenetic Proteins