[Effect of cardiocyclide on the electrophysiological parameters of heart in experiments with vagus nerve excitation in narcotized dogs].
The new class III antiarrhythmic agent cardiocyclide effectively suppresses atrioventricular fibrillations caused by the vagus nerve excitation in narcotized dogs. The electrophysiological effect of cardiocyclide was studied by method of programmed electric stimulation of myocardium on the background of excitation of the a peripheral segment of the right vagus by current pulses of increasing frequency. On this background, cardiocyclide exhibited characteristic effects manifested primarily in the repolarization and the AV node conduction. In addition, the drug eliminated suppression of the sinus and atrioventricular nodes and changes in the atrioventricular conduction caused by the vagus nerve. This drug effect was dose-dependent. The action of cardiocyclide in response to activation of the parasympathetic nervous system was independent of the frequency of the induced heart rate.
Kaverina
N V
NV
Lyskovets
V V
VV
Popova
E V
EV
D000085:Acetates / Q000494:pharmacology*; D000818:Animals; D003510:Cyclohexanes / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004553:Electric Conductivity; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects*; D014630:Vagus Nerve
D000085:Acetates; D003510:Cyclohexanes; C478369:N,N-dicyclohexylamide-N'-(3-diethylaminopropyl)-N-(N-nitrobenzoyl) aminoacetic acid hydroxyoxalate