Bioactive triterpenoids from Vochysia pacifica interact with cyclic nucleotide phosphodiesterase isozyme PDE4.
Several species of the genus Vochysia (Vochysiaceae) are used by traditional communities in South America to relieve ailments linked to inflammation, such as skin sores, asthma and pulmonary congestion. As the cAMP phosphodiesterase 4 isozyme (PDE4) is currently considered as an intracellular target for new antiinflammatory drugs, several constituents of Vochysia pacifica Cuatrec., an endemic tree from the Western coast of Colombia, were tested for their ability to inhibit PDE4. Purification of the methanol extract of the stem bark of this species led to the isolation of seven known triterpene derivatives: betulinic acid, sericic acid, 24-hydroxytormentic acid, trachelosperogenin B, 24-hydroxytormentic acid glucosyl ester, quadranoside I and niga-ichigoside F1. One triterpene glycoside, quadranoside I, and two triterpenes, betulinic and sericic acids, exhibited mild inhibitory activity on the isolated PDE4 isozyme.
Weniger
Bernard
B
UMR/CNRS 7081, Faculté de Pharmacie, Université Louis Pasteur, Strasbourg, France.
Lobstein
Annelise
A
Um
Byung-Hun
BH
Vonthron-Sénéchau
Catherine
C
Anton
Robert
R
Usuga
Nora Jiménez
NJ
Basaran
Hélène
H
Lugnier
Claire
C
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors / Q000187:drug effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D006801:Humans; D020128:Inhibitory Concentration 50; D007527:Isoenzymes; D027822:Myrtaceae; D009712:Nucleotides, Cyclic / Q000737:chemistry*; D010726:Phosphodiesterase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014315:Triterpenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007527:Isoenzymes; D009712:Nucleotides, Cyclic; D010726:Phosphodiesterase Inhibitors; D010936:Plant Extracts; D014315:Triterpenes; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4