Investigation of some topical formulations containing dexpanthenol.
Owing to its ability to regenerate epidermal cells Dexpanthenol (D-panthenol; chemically known as (+)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide) has found use for the treatment of patholytic ileus and postoperative distention. The purpose of research was to develop a gel containing dexpanthenol by monitoring the effect of various concentrations of a gelating agent on the activity of the ciliary apparatus. A system containing 2.5% of hydroxyethylcellulose was optimal for the preparation of the gel. Together with a formulation containing 5% of dexpanthenol, drops with equal concentration of the active compound were tested for comparison. Physical characteristics, such as osmotic pressure, acidity, density and viscosity of the preparation were determined as well as its microbiological sterility. The anti-inflammatory activity of the gel was determined following its topical application. Epidermal tests showed its good tolerance after topical application to the shaved skin of guinea pigs.
Stozkowska
Wiesława
W
Laboratory of Social Pharmacy, Department of Inorganic Chemistry, Medical University of Gdańsk, 80-416 Gdańsk, Poland. WSTO@farmacja.amg.gda.pl
Piekoś
Ryszard
R
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D003877:Dermatitis, Contact / Q000188:drug therapy; D005079:Excipients; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D020100:Hydrogels; D007202:Indicators and Reagents; D008297:Male; D008875:Middle Aged; D010205:Pantothenic Acid / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D005079:Excipients; D020100:Hydrogels; D007202:Indicators and Reagents; D010205:Pantothenic Acid; C007288:dexpanthenol