[Purification and characteristics of polypeptide with inhibition of platelet aggregation from Agkistrodon blomhoffii Bioe].
A polypeptide, SV-PP-2, was purified from Agkistrodon blomhoffii Bioe by HPLC C18 column. The SV-PP-2 has molecular weight of 23339.00 Da, and can inhibit the ADP-induced platelet aggregation in dose-dependent manner. There have been no such polypeptides reported yet which has inhibition of platelet aggregation and similar molecular weight to SV-PP-2.
Xu
Wei
W
Guangdong Key Lab for Drug Screening, Nanfang Medical University, Guangzhou.
Wu
Shaoyu
S
Zhang
Jiajie
J
Li
Zhiqin
Z
Wu
Shuguang
S
D017836:Agkistrodon; D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004305:Dose-Response Relationship, Drug; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D008419:Materia Medica / Q000302:isolation & purification / Q000494:pharmacology*; D010455:Peptides / Q000302:isolation & purification* / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D011817:Rabbits; D012910:Snake Venoms / Q000737:chemistry*
D008419:Materia Medica; D010455:Peptides; D010975:Platelet Aggregation Inhibitors; D012910:Snake Venoms