title: Cognitive changes in children treated for acute lymphoblastic leukemia with chemotherapy only according to the Pediatric Oncology Group 9605 protocol.
abstract: The purpose of this study was to examine cognitive functioning and neuroimaging in children with leukemia treated with the Pediatric Oncology Group 9605 protocol at the Children's Hospital of Eastern Ontario. Mean age at diagnosis was 4.88 +/- 2.54 years. The mean (n = 24) Wechsler Verbal and Performance IQ fell in the low-average range (87.33 +/- 15.69 and 84.83 +/- 19.11, respectively). Mean (n = 20) Verbal and Visual Memory Indexes of 82.95 +/- 15.46 and 88.30+/- 10.80, respectively, were obtained. The proportion of scores on measures of intelligence and memory falling > 1 SD below the normative mean was substantially higher than expected. Paired t-test suggested that Wechsler Verbal IQ and memory remained stable, whereas Wechsler Performance IQ declined significantly. The results of growth curve analyses replicated these findings and suggested a significant adverse effect of cumulative dosage of intrathecal methotrexate on estimated Wechsler Performance IQ. Although only two children experienced seizures, 78% of the group showed leukoencephalopathy on at least one magnetic resonance image. Reliance on seizures as a predictor of leukoencephalopathy might underestimate the incidence of neurotoxicity.
authors.affiliation: Oncology/Medical Day Patient Service Unit Children's Hospital of Eastern Ontario, Ottawa, ON. montour@cheo.on.ca
authors.forename: Isabelle
authors.initials: I
authors.lastname: Montour-Proulx
authors.forename: Sally M
authors.initials: SM
authors.lastname: Kuehn
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Keene
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Barrowman
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Hsu
authors.forename: Mary-Ann
authors.initials: MA
authors.lastname: Matzinger
authors.forename: Hal
authors.initials: H
authors.lastname: Dunlap
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Halton
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001921:Brain / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D003072:Cognition Disorders / Q000139:chemically induced*; D015331:Cohort Studies; D003561:Cytarabine / Q000008:administration & dosage; D005260:Female; D006397:Hematinics / Q000008:administration & dosage; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects; D009483:Neuropsychological Tests; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000473:pathology; D012189:Retrospective Studies; D014888:Wechsler Scales
chemical_list: D000893:Anti-Inflammatory Agents; D000964:Antimetabolites, Antineoplastic; D006397:Hematinics; D003561:Cytarabine; D002955:Leucovorin; D006854:Hydrocortisone; D008727:Methotrexate