[Statistical study and clinical results by comparison of two different protocols in the treatment of sudden hearing loss].
Sudden deafness goes on being a clinical entity of unknown cause for which several theories and treatments have been proposed. We are reporting a comparative study of two different protocols that we have performed on 60 patients (divided in two groups of 30) diagnosed and admitted with sudden hearing loss between 1989 and 2003. The main goal is to prove if there is a statistical and significant difference among both, in respect of the audiologic improvement obtained, after two weeks of therapy at east. We have applied the normal approximation of Mann-Whitney's test and we can argue, after its result, our current protocol (piracetam, pentoxifiline, metilprednisolone), which includes 4 days of endovenous treatment another 10 days at home. The presence of vestibular symptoms darkens the prognosis since about 95% of the patients with them have not improved significantly (p<0.05).
Pino Rivero
V
V
Facultativo Especialista de Otorrinolaringología, Complejo Hospitalario Infanta Cristina, Badajoz. vicentepinorivero@terra.com
Trinidad Ruíz
G
G
Marcos García
M
M
Montero García
C
C
González Palomino
A
A
Pantoja Hernández
C G
CG
Pardo Romero
G
G
Blasco Huelva
A
A
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002985:Clinical Protocols; D004334:Drug Administration Schedule; D004358:Drug Therapy / Q000706:statistics & numerical data*; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D003639:Hearing Loss, Sudden / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D018697:Nootropic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D010889:Piracetam / Q000008:administration & dosage / Q000627:therapeutic use*; D011282:Pregnenediones / Q000008:administration & dosage / Q000627:therapeutic use*
D000893:Anti-Inflammatory Agents; D004791:Enzyme Inhibitors; D018697:Nootropic Agents; D011282:Pregnenediones; C021988:deflazacort; D008775:Methylprednisolone; D010889:Piracetam