Cytomegalovirus retinitis in Wegener's granulomatosis: case report and review of the literature.
OBJECTIVE
To present the first case of cytomegalovirus (CMV) retinitis in a Wegener's granulomatosis patient on systemic cyclosporine A (CsA) therapy.


METHODS
A 41-year-old patient was treated with systemic CsA for c-ANCA positive Wegener's granulomatosis. Four weeks later he presented with blurred vision and a retinitis was diagnosed in the right eye. After detection of CMV DNA by polymerase chain reaction (PCR), the patient was treated with intravenous gancyclovir. Due to bone marrow toxicity, systemic antiviral therapy was discontinued and an intravitreal gancyclovir pellet was implanted.


RESULTS
The retinitis lesions were scarified under this therapy and the patient's visual function was restored completely.


CONCLUSIONS
Cytomegalovirus retinitis can occur under systemic monotherapy with CsA in patients with systemic vasculitis. Intraocular virus DNA detection by PCR is recommended to rule out retinal involvement of the underlying vasculitis in atypical cases and to preserve the patient's visual acuity.
Bertelmann
Eckart
E
Clinic of Ophthalmology, Charité- University School of Medicine Berlin, Berlin, Germany. Eckart.Bertelmann@charite.de
Liekfeld
Anja
A
Pleyer
Uwe
U
Hartmann
Christian
C
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D016572:Cyclosporine / Q000627:therapeutic use; D017726:Cytomegalovirus Retinitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D004279:DNA, Viral / Q000032:analysis; D015774:Ganciclovir / Q000627:therapeutic use; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D016133:Polymerase Chain Reaction
D000998:Antiviral Agents; D004279:DNA, Viral; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D015774:Ganciclovir