title: Dose calibration of nonconventional treatment systems applied to helical tomotherapy.
abstract: Current dosimetric protocols based on the absorbed dose (AAPM TG-51 and IAEA TRS-398 protocols) require calibration measurements under reference conditions. For some radiotherapy systems, this requirement cannot be met, and calibration has to be performed under nonreference experimental conditions. In order to solve this problem, both protocols can be extended by inclusion of the measured-to-reference conversion factor, k(mr). In order to determine this factor, basic dosimetric quantities, like stopping power ratios, mass attenuation coefficients and chamber correction factors have to be calculated. If measurements are not feasible, accurate Monte Carlo modeling is required. The extension of the protocols is illustrated using the case of the helical tomotherapy radiation unit, where the typical calibration measurement conditions are the 10 x 5 cm2 field size and the 85 cm surface source distance, limited by the system design. It was calculated that the k(mr) factor for this conditions is close to unity (0.997+/-0.001). In addition, the deviation of the measurement conditions from the reference conditions results in the change of the quality conversion factor (approximately 0.995-0.998, depending on the ionization chamber used). This change is the same regardless of the used calibration protocol. For smaller field sizes the corrections become more significant, resulting in the total correction factor compared to the reference conditions of up to 1.5% for the smallest considered field size of 2 x 2 cm2.
authors.affiliation: Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Jeraj
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Mackie
authors.forename: John
authors.initials: J
authors.lastname: Balog
authors.forename: Gustavo
authors.initials: G
authors.lastname: Olivera
mesh_terms: D000465:Algorithms; D002138:Calibration / Q000592:standards; D003198:Computer Simulation; D017408:Guidelines as Topic; D008954:Models, Biological; D015233:Models, Statistical; D011874:Radiometry / Q000379:methods* / Q000592:standards*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods* / Q000592:standards*; D020266:Radiotherapy, Conformal / Q000295:instrumentation / Q000379:methods* / Q000592:standards*; D012015:Reference Standards; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D036542:Tomography, Spiral Computed / Q000379:methods* / Q000592:standards