Synthesis and in vitro antitumor activity of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains.
A series of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains were synthesized and tested for their in vitro antitumor activity against human myelogenous leukemia K562 cells. Among them, (3,4-dihydro-2-methyl-4-oxoquinazolin-6-yl)methyl 4-(4-fluorophenyl)piperazine-1-carbodithioate 8q exhibited significant inhibitory activity against K562 cells with IC(50) value of 0.5 microM.
Cao
Sheng-Li
SL
Department of Chemistry, Capital Normal University, Beijing 100037, China. caoshengli@tsinghua.org.cn
Feng
Yu-Ping
YP
Jiang
Yu-Yang
YY
Liu
Shi-Ying
SY
Ding
Guo-Yu
GY
Li
Run-Tao
RT
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D020014:K562 Cells; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology; D052999:Quinazolinones; D013329:Structure-Activity Relationship; D013859:Thiocarbamates / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D011799:Quinazolines; D052999:Quinazolinones; D013859:Thiocarbamates; C061339:4-hydroxyquinazoline