title: [Thrombolysis in stroke: inappropriate consideration of the 'window period' as the time available].
abstract: OBJECTIVE
  The earlier r-TPA is administered in ischaemic strokes, the more effective it is. The aim of this study is to analyse the delay times in health care afforded in a consecutive series of cases that had received treatment, with a view to shortening them.
  
  
  METHODS
  We analysed the medical records of the first patients to be treated in our centre. The paper describes several variables involving demographic and clinical factors, as well as the delay in entering the Emergency department, performing a CAT scan and especially the time elapsed between the CAT scan and starting treatment. We have examined the existence of an inappropriate correlation between delays that should be independent of one another.
  
  
  RESULTS
  The mean age of the 17 patients treated was 68 years and they had a stroke severity score of 17 points on the NIHSS. The mean time of delay until arrival, arrival-CAT, and CAT-treatment were slightly under 1 hour each, and onset-treatment delay was 165 minutes, which is very close to the limit of the therapeutic window period. We found a strong inverse linear association between the time elapsed between onset and the CAT scan, and from the latter to the beginning of treatment (Spearman's r: -0.664, p = 0.004).
  
  
  CONCLUSIONS
  Findings indicate that in our hospital, as in other centres in the initial phases of implementation, the therapeutic time window for intravenous thrombolysis in ischaemic stroke tends to run out. It must be highlighted that the resolve of the physician who indicates the treatment exerts a decisive effect on the delay.
authors.affiliation: Servicio de Neurología, Hospital Virgen de las Nieves, Granada, Spain. jmaestrem@meditex.es
authors.forename: J F
authors.initials: JF
authors.lastname: Maestre-Moreno
authors.forename: M D
authors.initials: MD
authors.lastname: Fernández-Pérez
authors.forename: C
authors.initials: C
authors.lastname: Arnáiz-Urrutia
authors.forename: A
authors.initials: A
authors.lastname: Mínguez
authors.forename: P
authors.initials: P
authors.lastname: Navarrete-Navarro
authors.forename: J
authors.initials: J
authors.lastname: Martínez-Bosch
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000188:drug therapy*; D015912:Thrombolytic Therapy; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D010959:Tissue Plasminogen Activator