Antitubercular agents. Part 2: new thiolactomycin analogues active against Mycobacterium tuberculosis.
Structurally modified analogues of naturally occurring antibiotic thiolactomycin, substituted at 4-position of the thiolactone ring have been prepared and evaluated for their antitubercular activity. Some of the compounds have exhibited potential activity against Mycobacterium tuberculosis.
Kamal
Ahmed
A
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India. ahmedkamal@iict.res.in
Shaik
Ahmad Ali
AA
Sinha
Rakesh
R
Yadav
J S
JS
Arora
Sudarshan K
SK
D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology
D000995:Antitubercular Agents; D007783:Lactones; D013438:Sulfhydryl Compounds; D013876:Thiophenes; C035068:thiolactomycin