Relationship between paraoxonase-1 (PON1) activity and lipoprotein (a) levels in Turkish coronary artery disease patients living in the Antalya region.
BACKGROUND
Turkish adults have a high incidence of coronary artery disease (CAD).


METHODS
The role of lipoprotein(a) (Lp[a]) as a risk factor for CAD and its association with paraoxonase-1 (PON1) activity and lipid peroxidation indicators were evaluated in Turkish subjects living in Antalya.


METHODS
Paraoxonase-1 activity, Lp(a), conjugated dienes (CD) and thiobarbituric acid-reactive substances (TBARS) levels were measured in 45 healthy controls and 72 CAD patients.


RESULTS
In CAD patients, decreased PON1 activity and increased Lp(a), CD and TBARS levels were observed. Risk factors associated with CAD included TBARS, age and CD.


CONCLUSIONS
Our results indicate an association between PON1 activity and Lp(a) level in CAD patients.
Göçmen
Yeşim A
YA
Departments of aBiochemistry bCardiology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
Semiz
Ender
E
Gümüşlü
Saadet
S
D043303:Aryldialkylphosphatase / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D016022:Case-Control Studies; D003327:Coronary Disease / Q000097:blood* / Q000453:epidemiology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015994:Incidence; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D011336:Probability; D011379:Prognosis; D012016:Reference Values; D018570:Risk Assessment; D012424:Rural Population; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis*; D014421:Turkey / Q000453:epidemiology
D015415:Biomarkers; D017270:Lipoprotein(a); D017392:Thiobarbituric Acid Reactive Substances; D043303:Aryldialkylphosphatase