title: [Current understanding of primary biliary cirrhosis].
abstract: OBJECTIVE
  To examine characteristics of the course of primary biliary cirrhosis (PBC).
  
  
  METHODS
  The study of 150 PBC patients aged 26-82 years used clinical, biochemical, immunological and morphological methods.
  
  
  RESULTS
  Antimitochondrial antibodies of type M2 (AMAM2) were detected in 85.4% patients with PBC. A positive correlation was found between clinicobiochemical activity of the disease and number of AMAM2. AMAM2-positive patients more frequently had extrahepatic manifestations, overlap syndrome, higher biochemical and immunological activity vs AMAM2-negative patients.
  
  
  CONCLUSIONS
  The following variants of PBC course were identified: classic AMAM2-positive, AMAM2-negative, overlapping of PBC and autoimmune hepatitis. Concentration of AMAM2 has diagnostic and prognostic value in PBC.
authors.forename: L Iu
authors.initials: LIu
authors.lastname: Il'ichenko
authors.forename: E V
authors.initials: EV
authors.lastname: Golovanova
authors.forename: T M
authors.initials: TM
authors.lastname: Tsaregorodtseva
authors.forename: T I
authors.initials: TI
authors.lastname: Serova
authors.forename: R B
authors.initials: RB
authors.lastname: Gudkova
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology*; D008099:Liver / Q000503:physiopathology; D008105:Liver Cirrhosis, Biliary / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D008931:Mitochondria, Muscle / Q000276:immunology
chemical_list: D000906:Antibodies; D001323:Autoantibodies; D007136:Immunoglobulins