title: Effect of the carbohydrate side-chain on the conformation of a glycoconjugate polystyrene in aqueous solution.
abstract: An oligomaltose-carrying polystyrene "glycoconjugate polystyrene" was synthesized by the homopolymerization of 4-vinylbenzylamine oligomaltonic amides, derived from maltose, maltotriose, maltopentaose, and maltoheptaose. The resultant amphiphilic glycoconjugate polystyrenes were dissolved in 0.1 M aqueous urea, and their structures characterized by small-angle X-ray scattering and molecular modeling. "Glycoconjugate polystyrene" was found to behave as a "molecular bottle brush", composed of a large pseudo-helical polystyrene backbone and carbohydrate brushes. A large pseudo-helical polystyrene backbone is formed by a random sequence of TT, TG, and/or TTGG. The results indicate that the cross-section of a backbone chain with smaller oligosaccharide side-chains is obliged to expand more than that with longer side-chains. Even with rigid hydrophilic pendant oligosaccharide chains, the larger pseudo-helix of the main chain could orient the side-chains so as to envelop the hydrophobic backbone in aqueous solution. Thus the conformation of the main chain is determined not only by the chemical nature of an oligosaccharide chain but also by its length.
authors.affiliation: Faculty of Textile Science and Technology, Shinshu University, Ueda-shi, Tokoda 3-15-1, 386-8567, Japan.
authors.forename: Isao
authors.initials: I
authors.lastname: Wataoka
authors.forename: Kazukiyo
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Kanji
authors.initials: K
authors.lastname: Kajiwara
mesh_terms: D003198:Computer Simulation; D006001:Glycoconjugates / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D009844:Oligosaccharides / Q000737:chemistry; D011137:Polystyrenes / Q000737:chemistry*; D012542:Scattering, Radiation; D014965:X-Rays
chemical_list: D006001:Glycoconjugates; D009844:Oligosaccharides; D011137:Polystyrenes