Cellular oscillators: rhythmic gene expression and metabolism.
Many biological processes are driven by biological clocks that, depending on the frequency they generate, are classified into ultradian, circadian and infradian oscillators. In virtually all light-sensitive organisms from cyanobacteria to humans, a circadian timing system adapts cyclic physiology to geophysical time. Recent evidence suggests that even in mammals circadian oscillators function in a cell-autonomous manner. In yeast, an ultradian oscillator regulates cyclic respiratory activity and global gene expression. Circadian oscillators and the ultradian yeast respiratory clock share at least four properties: they follow limit-cycle kinetics, interweave with cellular metabolism, are temperature-compensated and influence the cell division clock.
Schibler
Ueli
U
Department of Molecular Biology and NCCR Frontiers in Genetics, Sciences III, University of Geneva, 30, Quai Ernest Ansermet, CH-1211 Geneva-4, Switzerland. Ueli.Schibler@molbio.unige.ch
Naef
Felix
F
D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D019069:Cell Respiration / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D013696:Temperature; D015003:Yeasts / Q000235:genetics / Q000378:metabolism
D018797:Cell Cycle Proteins