title: Laboratory markers associated with progression of HIV infection.
abstract: Infection with HIV may develop to AIDS at different rates in different individuals, with a spectrum varying from rapid progression to long-term non-progression. The variable course of HIV-1 infection causes emotional trauma for the infected person and complicates the design and interpretation of therapeutic trials because of unrecognized differences in prognosis. Owing to the variable clinical expression of HIV infection, the use of non-clinical disease markers has become important to patient management. Thus, it is essential to have tests which can accurately assess the stage of infection in an individual, as well as predict its course and monitor its progression. These laboratory tests are valuable during the period of clinical latency and subsequently supplement various clinical parameters.
authors.affiliation: Nelson R Mandela School of Medicine, University of Kwazulu-Natal, HIV Pathogenesis Programme, DDMRI, 719 Umbilo Road, Congella, Durban, 4013 Natal, South Africa. kiepiela@ukzn.ac.za
authors.forename: P
authors.initials: P
authors.lastname: Kiepiela
authors.forename: A N
authors.initials: AN
authors.lastname: Smith
authors.forename: E
authors.initials: E
authors.lastname: Rosenberg
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D018791:CD4 Lymphocyte Count; D016207:Cytokines / Q000097:blood; D018450:Disease Progression; D005260:Female; D005838:Genotype; D016655:HIV Core Protein p24 / Q000097:blood; D015658:HIV Infections / Q000175:diagnosis* / Q000821:virology; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D008297:Male; D019798:Neopterin / Q000097:blood; D012367:RNA, Viral / Q000032:analysis; D019562:Viral Load; D001613:beta 2-Microglobulin / Q000032:analysis
chemical_list: D015415:Biomarkers; D016207:Cytokines; D016655:HIV Core Protein p24; D012367:RNA, Viral; D001613:beta 2-Microglobulin; D019798:Neopterin