Glutamate antagonists attenuate the action of NC-1900, a vasopressin fragment analog, on passive avoidance task performance in mice.
To examine the relationship between glutamate receptors and the action of NC-1900 on a step-through passive avoidance (PA) task in mice, MK-801, an NMDA receptor blocker, and (S)-4-carboxyphenylglycine (4CPG), a group I metabotropic receptor antagonist, were administered intraventricularly (i.c.v.) singly or as co-injections. The i.c.v. injection of MK-801 (0.8 microg) or 4CPG (2 microg) decreased the latency on the PA task. NC-1900 (1 ng/kg, subcutaneously (s.c.)) alone prolonged the latency on the retention trial in the PA task. MK-801 (0.2 and 0.8 microg) or 4CPG (0.5 and 2 microg) significantly inhibited the action of NC-1900, while the s.c. injection of NC-1900 did not affect latency in mice that received i.c.v. co-injection of MK-801 and 4CPG at any of the doses tested. These results suggest that glutamate receptors participate in the action of NC-1900 on learning and memory in PA task performance.
Sato
Tomoaki
T
Department of Applied Pharmacology, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka-8, Kagoshima 890-8544, Japan. tomsato@dentb.hal.kagoshima-u.ac.jp
Ishida
Takayuki
T
Tanaka
Koh-ichi
K
Chowdhurry
Nafees
N
Irifune
Masahiro
M
Hirate
Kenji
K
Mimura
Tamotsu
T
Nishikawa
Takashige
T
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001565:Benzoates / Q000494:pharmacology; D016291:Dizocilpine Maleate / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D018698:Glutamic Acid / Q000502:physiology; D005998:Glycine / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D016202:N-Methylaspartate / Q000494:pharmacology; D009842:Oligopeptides / Q000037:antagonists & inhibitors*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors; D017470:Receptors, Glutamate / Q000187:drug effects; D014667:Vasopressins / Q000037:antagonists & inhibitors
D001565:Benzoates; D018691:Excitatory Amino Acid Antagonists; C115056:NC 1900; D009842:Oligopeptides; D017470:Receptors, Glutamate; D014667:Vasopressins; D018698:Glutamic Acid; D016202:N-Methylaspartate; D016291:Dizocilpine Maleate; C079693:4-carboxyphenylglycine; D011761:Pyrrolidonecarboxylic Acid; D005998:Glycine