The value of tartrate resistant acid phosphatase (TRAP) immunoreactivity in diagnosis of hairy cell leukemia.
Hairy cell leukemia (HCL) is a rare chronic B-cell lymphoproliferative disorder characterized by splenomegaly, pancytopenia, and circulating atypical lymphocytes with circumferential cytoplasmic projections. We investigated the specificity and the sensitivity of anti-TRAP antibody immunoreactivity in 57 cases of HCL. We found that there is a statistically highly significant difference between TRAP immunoreactivities of the study and the control groups, and HCL can be diagnosed by TRAP immunoreactivity in bone marrow trephine biopsy materials with a specificity of 98.27 % and a sensitivity of 100%.
Akkaya
Hampar
H
Pathology Department, Baskent University, Medical Faculty, Alanya Medical Center, 07400 Alanya-Antalya, Turkey. hamparsum@superonline.com
Dogan
Oner
O
Agan
Mehmet
M
Dincol
Guncag
G
D000135:Acid Phosphatase / Q000032:analysis / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000276:immunology*; D018951:Antigens, CD20 / Q000032:analysis / Q000276:immunology; D001854:Bone Marrow Cells / Q000276:immunology; D018956:CD5 Antigens / Q000032:analysis / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000032:analysis / Q000276:immunology*; D007943:Leukemia, Hairy Cell / Q000175:diagnosis* / Q000201:enzymology; D008099:Liver / Q000276:immunology; D010010:Osteoclasts / Q000737:chemistry; D013154:Spleen / Q000276:immunology; D000071681:Tartrate-Resistant Acid Phosphatase
D000911:Antibodies, Monoclonal; D018951:Antigens, CD20; D018956:CD5 Antigens; D007527:Isoenzymes; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase