title: Intentional delay of human hepatocarcinogenesis due to suppression of chronic hepatitis.
abstract: Human hepatocellular carcinomas (HCCs) are preceded by chronic hepatitis and cirrhosis. Despite a clear viral etiology [hepatitis B virus (HBV) and hepatitis C virus (HCV)] of human hepatocarcinogenesis, the mechanism is complex and the distinct molecular pathway or molecules to explain this phenomenon are not yet known. Hepatitis viral, 'inflammation-mediated' hepatocarcinogenesis greatly influences the incidence of somatic genetic events in hepatocytes by increasing the number of target cells, or the proliferation of once-hit hepatocytes, eventually leading to HCCs. These conditions may be designated as the 'hypercarcinogenic state'. Our goal is to lead the 'hypercarcinogenic state' to the 'normo- or hypocarcinogenic' state and to prevent HCC development (intentional delay of HCC).
authors.affiliation: Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan. ohino@med.juntendo.ac.jp
authors.forename: Okio
authors.initials: O
authors.lastname: Hino
mesh_terms: D022762:CCAAT-Enhancer-Binding Proteins; D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000517:prevention & control*; D002352:Carrier Proteins / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D006360:Heat-Shock Proteins / Q000235:genetics; D016174:Hepacivirus / Q000254:growth & development / Q000502:physiology; D006515:Hepatitis B virus / Q000502:physiology; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000503:physiopathology* / Q000821:virology; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000503:physiopathology* / Q000821:virology; D022781:Hepatocytes / Q000473:pathology / Q000821:virology; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology / Q000517:prevention & control*; D020641:Polymorphism, Single Nucleotide
chemical_list: D022762:CCAAT-Enhancer-Binding Proteins; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D006360:Heat-Shock Proteins; C094867:YBX3 protein, human