title: Cellular oscillators: rhythmic gene expression and metabolism.
abstract: Many biological processes are driven by biological clocks that, depending on the frequency they generate, are classified into ultradian, circadian and infradian oscillators. In virtually all light-sensitive organisms from cyanobacteria to humans, a circadian timing system adapts cyclic physiology to geophysical time. Recent evidence suggests that even in mammals circadian oscillators function in a cell-autonomous manner. In yeast, an ultradian oscillator regulates cyclic respiratory activity and global gene expression. Circadian oscillators and the ultradian yeast respiratory clock share at least four properties: they follow limit-cycle kinetics, interweave with cellular metabolism, are temperature-compensated and influence the cell division clock.
authors.affiliation: Department of Molecular Biology and NCCR Frontiers in Genetics, Sciences III, University of Geneva, 30, Quai Ernest Ansermet, CH-1211 Geneva-4, Switzerland. Ueli.Schibler@molbio.unige.ch
authors.forename: Ueli
authors.initials: U
authors.lastname: Schibler
authors.forename: Felix
authors.initials: F
authors.lastname: Naef
mesh_terms: D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D019069:Cell Respiration / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D013696:Temperature; D015003:Yeasts / Q000235:genetics / Q000378:metabolism
chemical_list: D018797:Cell Cycle Proteins