Argatroban for anticoagulation during cardiopulmonary bypass in an infant.
Heparin induced thrombocytopenia (HIT) is a rare, but potentially life-threatening complication of heparin therapy. In patients with HIT, alternative means of anticoagulation are necessary. The authors present an infant with HIT who required anticoagulation during cardiopulmonary bypass for tricuspid valve excision in the treatment of bacterial endocarditis. The direct thrombin inhibitor, argatroban, was successfully used. Previous reports regarding the use of argatroban and other nonheparin anticoagulants for anticoagulation are reviewed and suggestions regarding argatroban dosing in infants are presented.
Dyke
Peter C
PC
Department of Child Health, University of Missouri, Columbia, MO, USA.
Russo
Pierantonio
P
Mureebe
Leila
L
Russo
Joanne
J
Tobias
Joseph D
JD
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000906:Antibodies / Q000032:analysis; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001120:Arginine / Q000031:analogs & derivatives; D002315:Cardiopulmonary Bypass; D004342:Drug Hypersensitivity; D004697:Endocarditis, Bacterial / Q000150:complications / Q000601:surgery; D006493:Heparin / Q000009:adverse effects* / Q000276:immunology; D006529:Hepatomegaly; D006801:Humans; D007223:Infant; D007431:Intraoperative Complications; D008297:Male; D010875:Pipecolic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D013163:Splenomegaly; D013449:Sulfonamides; D013921:Thrombocytopenia / Q000150:complications; D014261:Tricuspid Valve / Q000601:surgery
D000900:Anti-Bacterial Agents; D000906:Antibodies; D000925:Anticoagulants; D010875:Pipecolic Acids; D013449:Sulfonamides; D006493:Heparin; D001120:Arginine; C031942:argatroban