title: Thrombosis in a pregnant hemophilia A carrier after intrapartum recombinant factor VIII.
abstract: BACKGROUND
  Symptomatic hemophilia A is a rare disorder in females. Pregnancy and delivery in such women can be life threatening. Obstetric management is challenging and requires a multidisciplinary approach to ensure a good outcome.
  
  
  METHODS
  A woman with hemophilia A delivered by cesarean developed a deep vein thrombosis 10 days postpartum after recombinant factor VIII administration.
  
  
  CONCLUSIONS
  Hemophilia A due to skewed X-inactivation is a rare cause of peripartum bleeding. Recombinant factor VIII administration can prevent hemorrhage during and after cesarean delivery but may be associated with development of deep vein thrombosis.
authors.affiliation: Department of Obstetrics and Gynecology, Arnold Palmer Hospital for Children and Women, Orlando Regional Healthcare, Orlando, Florida, USA. zoika1@yahoo.com
authors.forename: Zoi
authors.initials: Z
authors.lastname: Russell
authors.forename: Dan
authors.initials: D
authors.lastname: Riconda
authors.forename: Lynda
authors.initials: L
authors.lastname: Pollack
authors.forename: Timothy D
authors.initials: TD
authors.lastname: O'Leary
authors.forename: S J
authors.initials: SJ
authors.lastname: Carlan
mesh_terms: D000328:Adult; D002585:Cesarean Section; D003937:Diagnosis, Differential; D005169:Factor VIII / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006467:Hemophilia A; D006579:Heterozygote; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D011644:Puerperal Disorders / Q000139:chemically induced / Q000175:diagnosis*; D011994:Recombinant Proteins / Q000008:administration & dosage* / Q000009:adverse effects; D020246:Venous Thrombosis / Q000139:chemically induced / Q000175:diagnosis*
chemical_list: D011994:Recombinant Proteins; D005169:Factor VIII