title: [Disseminated histoplasmosis: an atypical ulcerous form in an HIV-infected patient].
abstract: BACKGROUND
  Histoplasma capsulatum var capsulatum is a dimorphic fungi predominating on the American continent. It is responsible for disseminated histoplasmosis associated with AIDS. The presentation in the form of cutaneous ulceration is uncommon and misleading.
  
  
  METHODS
  A 25 year-old man presented with 3 ulcerations, of 2 to 4 cm in diameter, localized on the lower lip and knees. The patient exhibited fever, alteration in his general status of health and a pulmonary interstitial syndrome. He was seropositive for the human immunodeficiency syndrome (HIV). His lymphocyte CD4+ level was of 1/mm3. Diagnosis of histoplasmosis was established by direct examination and culture of the cutaneous ulcerations and bronchoalveolar washing fluid.
  
  
  CONCLUSIONS
  The clinical aspect of cutaneous localizations of disseminated histoplasmosis is usually multiple, disseminated, papular or nodular-type lesions. Ulcerations represent less than 20% of the cases described. In our patient, the aspect of the lesions at first evoked cutaneous leishmaniosis. Direct mycological examination followed by culture confirmed the final diagnosis.
authors.affiliation: Service de Dermatologie, Centre Hospitalier de Cayenne, Guyane.
authors.forename: P
authors.initials: P
authors.lastname: Couppié
authors.forename: M
authors.initials: M
authors.lastname: Roussel
authors.forename: N
authors.initials: N
authors.lastname: Thual
authors.forename: C
authors.initials: C
authors.lastname: Aznar
authors.forename: J
authors.initials: J
authors.lastname: Laifaoui
authors.forename: M
authors.initials: M
authors.lastname: Demar
authors.forename: D
authors.initials: D
authors.lastname: Sainte-Marie
authors.forename: M
authors.initials: M
authors.lastname: Huerre
authors.forename: E
authors.initials: E
authors.lastname: Grosshans
authors.forename: B
authors.initials: B
authors.lastname: Carme
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000150:complications*; D006658:Histoplasma / Q000472:pathogenicity; D006660:Histoplasmosis / Q000209:etiology / Q000473:pathology* / Q000821:virology*; D006801:Humans; D007717:Knee / Q000473:pathology; D008046:Lip / Q000473:pathology; D008297:Male; D012883:Skin Ulcer / Q000209:etiology / Q000382:microbiology*