title: Long-term follow-up for brain tumor development after childhood exposure to ionizing radiation for tinea capitis.
abstract: Ionizing radiation is an established risk factor for brain tumors, yet quantitative information on the long-term risk of different types of brain tumors is sparse. Our aims were to assess the risk of radiation-induced malignant brain tumors and benign meningiomas after childhood exposure and to investigate the role of potential modifiers of that risk. The study population included 10,834 individuals who were treated for tinea capitis with X rays in the 1950s and two matched nonirradiated groups, comprising population and sibling comparison groups. The mean estimated radiation dose to the brain was 1.5 Gy. Survival analysis using Poisson regression was performed to estimate the excess relative and absolute risks (ERR, EAR) for brain tumors. After a median follow-up of 40 years, an ERR/Gy of 4.63 and 1.98 (95% CI = 2.43-9.12 and 0.73-4.69) and an EAR/Gy per 10(4) PY of 0.48 and 0.31 (95% CI = 0.28-0.73 and 0.12-0.53) were observed for benign meningiomas and malignant brain tumors, respectively. The risk of both types of tumors was positively associated with dose. The estimated ERR/Gy for malignant brain tumors decreased with increasing age at irradiation from 3.56 to 0.47 (P = 0.037), while no trend with age was seen for benign meningiomas. The ERR for both types of tumor remains elevated at 30-plus years after exposure.
authors.affiliation: Cancer & Radiation Epidemiology Unit, Sheba Medical Center, Tel-Hashomer, Israel. siegals@gertner.health.gov.il
authors.forename: Siegal
authors.initials: S
authors.lastname: Sadetzki
authors.forename: Angela
authors.initials: A
authors.lastname: Chetrit
authors.forename: Laurence
authors.initials: L
authors.lastname: Freedman
authors.forename: Marilyn
authors.initials: M
authors.lastname: Stovall
authors.forename: Baruch
authors.initials: B
authors.lastname: Modan
authors.forename: Ilya
authors.initials: I
authors.lastname: Novikov
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D001921:Brain / Q000528:radiation effects*; D001932:Brain Neoplasms / Q000453:epidemiology*; D015984:Causality; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D015897:Comorbidity; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007223:Infant; D007557:Israel / Q000453:epidemiology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D011829:Radiation Dosage; D011878:Radiotherapy / Q000706:statistics & numerical data*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D017678:Sex Distribution; D014006:Tinea Capitis / Q000453:epidemiology* / Q000532:radiotherapy*