Physiologic consequences of acute renal failure on the critically ill.
Acute renal failure (ACF) causes increased levels of uremic retention products, acidosis, and volume overload. These factors contribute to a dysregulated inflammatory response and decreased immunity, and interfere with normal function of many organs. ACF may play an important role in the etiology of multiple organ dysfunction.
Hoste
Eric A J
EA
Intensive Care Unit, Ghent University Hospital, De Pintelaan 185, Ghent 9000, Belgium. eric.hoste@ugent.be
De Waele
Jan J
JJ
D000138:Acidosis / Q000503:physiopathology; D058186:Acute Kidney Injury / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D009102:Multiple Organ Failure / Q000209:etiology; D012769:Shock / Q000209:etiology; D014511:Uremia / Q000503:physiopathology; D014883:Water-Electrolyte Imbalance / Q000503:physiopathology