title: [Spectral analysis of the electroencephalogram in children with systemic lupus erythematosus].
abstract: BACKGROUND
  Systemic lupus erythematosus (SLE) is an autoimmune disease that affects different systems and organs, including the central nervous system (CNS). It has been suggested that about 40% of the cases of neuropsychiatric lupus (NPSLE) develop before SLE is diagnosed or at the same time it is being carried out, and 63% appear during the first year following diagnosis.
  
  
  OBJECTIVE
  The aim of this study was to check the hypothesis that the electroencephalogram (EEG) may be sensitive to the damage to the CNS in children with SLE in whom there is still no clinical evidence of NPSLE.
  
  
  METHODS
  EEG recordings were performed in 30 children with a diagnosis of SLE with or without signs of a neuropsychiatric syndrome. The results of the EEG were evaluated visually and analysed quantitatively.
  
  
  RESULTS
  The visual inspection of the EEG showed the presence of alterations in 44.5% of the children with SLE and in 76.9% of those with NPSLE. There were significant differences in Student's t test (p = 0.0055) between the two groups for the analysis of the broadband spectral measurements. The narrow band analysis revealed a significant increase in the theta and delta frequencies in children with SLE as compared to standard values, whereas in children with NPSLE significant differences were found in the fast bands in frontal regions.
  
  
  CONCLUSIONS
  Spectral analysis of the narrow band could help to confirm diagnoses of NPSLE, while anomalies in the slow bands could be an early marker of damage to the CNS although there are still no symptoms of the disease.
authors.affiliation: Departamento de Neurofisiología Clínica, Centro de Neurociencias de Cuba, La Habana, Cuba. rene@cneuro.edu.cu
authors.forename: R
authors.initials: R
authors.lastname: Rodríguez-Valdés
authors.forename: L
authors.initials: L
authors.lastname: Aguilar-Fabré
authors.forename: J
authors.initials: J
authors.lastname: Ricardo-Garcell
authors.forename: A
authors.initials: A
authors.lastname: Alvarez-Amador
authors.forename: M
authors.initials: M
authors.lastname: Caraballo-Pupo
mesh_terms: D000293:Adolescent; D001927:Brain Diseases / Q000209:etiology* / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000503:physiopathology*; D008297:Male