title: Oxygen JNKies: phosphatases overdose on ROS.
abstract: Proinflammatory cytokine TNFalpha triggers cell death by inducing reactive oxygen species (ROS). These then inflict cytotoxicity through downstream activation of the JNK MAPK cascade. Yet the mechanisms by which ROS trigger JNK signaling have remained elusive. In a recent issue of Cell, Kamata et al. now provide one such mechanism.
authors.affiliation: The Ben May Institute for Cancer Research, The University of Chicago, 924 East 57th Street, Chicago, Illinois 60637, USA.
authors.forename: Can G
authors.initials: CG
authors.lastname: Pham
authors.forename: Salvatore
authors.initials: S
authors.lastname: Papa
authors.forename: Concetta
authors.initials: C
authors.lastname: Bubici
authors.forename: Francesca
authors.initials: F
authors.lastname: Zazzeroni
authors.forename: Guido
authors.initials: G
authors.lastname: Franzoso
mesh_terms: D017209:Apoptosis / Q000502:physiology; D004789:Enzyme Activation; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism*; D020935:MAP Kinase Signaling System / Q000502:physiology; D010100:Oxygen / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D047888:Receptors, Tumor Necrosis Factor, Type I; D014409:Tumor Necrosis Factor-alpha; D048031:JNK Mitogen-Activated Protein Kinases; D010744:Phosphoric Monoester Hydrolases; D010100:Oxygen