[Effect of melatonin on the glucocorticoid-induced immunity suppression studied in vitro].
The effect of epiphyseal hormone melatonin on the cortisole-induced decrease in peripheral blood mononuclear cell (PBMC) proliferation and changes in T-helper type 1 cytokine (IFN-gamma) and type 2 cytokine (IL-4) expression was studied in vitro in cell culture supernatants. Cortisol (10(-6) M) decreased PBMC proliferation, suppressed IFN-gamma production, and did not influence IL-4 production. Melatonin in physiological concentrations (10(-11) M) partly reduced the cortisol-induced PBMC proliferation. This effect was not associated with changes in the IFN-gamma and IL-4 production in the cell culture.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D007371:Interferon-gamma / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D008550:Melatonin / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D000893:Anti-Inflammatory Agents; D015847:Interleukin-4; D007371:Interferon-gamma; D008550:Melatonin; D006854:Hydrocortisone