Stretch-activated channels: a mini-review. Are stretch-activated channels an ocular barometer?
All cells are subject to physical forces by virtue of their position in a dynamically changing environment. This review outlines the various putative 'mechanosensors', or sensors of pressure cells possess, and discusses in particular the role stretch-activated membrane channels play in pressure recognition and transduction. The widespread occurrence of these channels is discussed and these 'mechanosensors' are related to pressure-related diseases, in particular, glaucoma.
Kalapesi
Freny B
FB
Department of Ophthalmology, Prince of Wales Hospital, University of New South Wales, Sydney, New South Wales, Australia.
Tan
James C H
JC
Coroneo
Minas T
MT
D005128:Eye Diseases / Q000503:physiopathology*; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology*; D008465:Mechanoreceptors / Q000502:physiology*; D015221:Potassium Channels / Q000502:physiology; D011312:Pressure; D013314:Stress, Mechanical
D007473:Ion Channels; C503432:KCNK4 protein, human; D015221:Potassium Channels