A MALDI-chip integrated system with a monitoring window.
The integration of a monitoring port along the microfluidic path of a MALDI-chip integrated device is described. Optimization of the microreactor design allows longer reaction and measuring times. The Schiff base reaction between 4-tert-butylaniline (1) and 4-tert-butylbenzaldehyde (2) in ethanol was carried out on-chip in the MALDI ionization chamber and the formed imine 3 was detected in real time, demonstrating the feasibility of the "monitoring window" approach. This preliminary result opens the way to on-chip kinetic studies by MALDI-MS, by opening multiple monitoring windows along the microchannel.
Brivio
Monica
M
Laboratory of Supramolecular Chemistry and Technology, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
Tas
Niels R
NR
Goedbloed
Martijn H
MH
Gardeniers
Han J G E
HJ
Verboom
Willem
W
van den Berg
Albert
A
Reinhoudt
David N
DN
D000814:Aniline Compounds / Q000737:chemistry; D001547:Benzaldehydes / Q000737:chemistry; D005240:Feasibility Studies; D007097:Imines / Q000032:analysis / Q000138:chemical synthesis; D056656:Lab-On-A-Chip Devices; D046208:Microchip Analytical Procedures / Q000379:methods; D044085:Microfluidics / Q000295:instrumentation* / Q000379:methods; D015394:Molecular Structure; D012545:Schiff Bases / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000295:instrumentation* / Q000379:methods; D013499:Surface Properties
D000814:Aniline Compounds; D001547:Benzaldehydes; D007097:Imines; D012545:Schiff Bases