[Studies on constituents from the fermentation of Alternalia sp].
OBJECTIVE
To study the metabolites of marine fungus Alternalia sp.


METHODS
Compounds were separated by column chromatography and their structures were elucidated by means of chemical and spectral analysis.


RESULTS
Six compounds were isolated from the ethyl acetate and n-butanol extracts of the fermentation of marine fungus Alternalia sp. Their structures were elucidated as p-benzyloxy-phenol ( I ), p-hydroxy phenyl ethylamine( II ), 3-hydroxymethyl-8-hydroxyl-pyrrolopiperazine-2, 5-dione ( III ), 3-isobutyl-6-secbutyl-piperazine-2, 5-dione (IV), 5alpha, 8alpha-epidioxy-ergosta-6, 22-diene-3beta-ol (V), 3beta-hydroxxy-cholesta-5-ene (VI).


CONCLUSIONS
Compounds I , II, III, IV have the activity of inducing morphological deformation of mycelia germinated from conidia of Pyricularia oryzae. Compounds I , II , III were isolated from the genus Alternalia for the first time.
Zhang
Hai-long
HL
School of Traditional Chinese Medicines, Shenyang Pharmaceutical University, Shenyang 110016, China.
Tian
Li
L
Fu
Hong wei
Hw
Pei
Yue-hu
YH
Hua
Hui-ming
HM
D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000187:drug effects; D005285:Fermentation; D005658:Fungi / Q000737:chemistry*; D015394:Molecular Structure; D010627:Phenethylamines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000935:Antifungal Agents; D010627:Phenethylamines; D010636:Phenols