Effect of noradrenaline and isoproterenol on lipopolysaccharide-induced tumor necrosis factor-alpha production in whole blood from patients with chronic heart failure and the role of beta-adrenergic receptors.
Increased levels of tumor necrosis factor-alpha (TNF-alpha) correlate with poor prognoses in chronic heart failure (CHF). This study demonstrated that noradrenaline and isoproterenol inhibit TNF-alpha production in patients with CHF in ex vivo whole blood in a dose-dependent fashion. The beta-blocker bisoprolol abolishes this effect.
von Haehling
Stephan
S
Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom. stephan.von.haehling@web.de
Genth-Zotz
Sabine
S
Bolger
Aidan P
AP
Kalra
Paul R
PR
Kemp
Michael
M
Adcock
Ian M
IM
Poole-Wilson
Philip A
PA
Dietz
Rainer
R
Anker
Stefan D
SD
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000328:Adult; D017298:Bisoprolol / Q000494:pharmacology; D002317:Cardiovascular Agents / Q000494:pharmacology*; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000096:biosynthesis / Q000187:drug effects*
D000319:Adrenergic beta-Antagonists; D002317:Cardiovascular Agents; D008070:Lipopolysaccharides; D011943:Receptors, Adrenergic, beta; D014409:Tumor Necrosis Factor-alpha; D007545:Isoproterenol; D009638:Norepinephrine; D017298:Bisoprolol