MagScrew total artificial heart in vivo performance above 200 beats per minute.
OBJECTIVE
Downsizing pulsatile devices requires an increase of beat rate if flow capacity is to be maintained. We applied this concept to the preclinical MagScrew total artificial heart (TAH).


METHODS
The device fills passively with a stroke volume of 45 ml and beat rates up to 250 beats per minute (bpm).


RESULTS
Stable hemodynamics were observed during a 30-day bovine implant with a flow of 8.7 +/- 1.2 L/min at beat rates of 204 +/- 18 bpm. Device filling was exceptional up to 250 bpm generating flow of greater than 12 L/min. Beat rate adapted to preload in a way similar to a Frank-Starling response. Left and right atrial pressures were balanced. The aortic pulse pressure was 49-70 mm Hg, which translates to a pulsatility index of 0.49-0.77. Organ functions were preserved and blood damage did not occur.


CONCLUSIONS
Increasing the beat rate while downsizing the MagScrew TAH was successful with strong flow generation by passive filling. Pulsatility was maintained at high beat rates. This innovative approach may be used to develop small pulsatile pumps.
Schenk
Soren
S
Department of Biomedical Engineering, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Weber
Stephan
S
Luangphakdy
Viviane
V
Klatte
Ryan S
RS
Flick
Christine R
CR
Chen
Ji-Feng
JF
Kopcak
Michael W
MW
Ootaki
Yoshio
Y
Kamohara
Keiji
K
Hirschman
Gordon B
GB
Vitale
Nicholas G
NG
Chapman
Peter A
PA
Smith
William A
WA
Fukamachi
Kiyotaka
K
D000818:Animals; D001794:Blood Pressure; D002417:Cattle; D006339:Heart Rate; D006354:Heart, Artificial; D013318:Stroke Volume