title: [Multiple template switches on LINE-directed reverse transcription: the most probable formation mechanism for the double and triple chimeric retroelements in mammals].
abstract: It was shown that the shuffling mechanism for transcribed genome components, which involves a template switch on the RNA reverse transcription using the L1 retroelement enzymatic machinery, is common in mammals. The occurrence frequency of the resulting chimeric retroelements in the genomes of rodents is twice as high as in the DNA of primates. Moreover, we proved that not only single but also double switches may occur in vivo, which result in the fusion of copies of three different transcripts. Many of the identified chimeras are transcribed in mammals.
authors.forename: E V
authors.initials: EV
authors.lastname: Gogvadze
authors.forename: A A
authors.initials: AA
authors.lastname: Buzdin
authors.forename: E D
authors.initials: ED
authors.lastname: Sverdlov
mesh_terms: D000818:Animals; D030561:Databases, Nucleic Acid; D015894:Genome, Human; D006801:Humans; D051379:Mice; D012194:RNA-Directed DNA Polymerase; D051381:Rats; D018626:Retroelements / Q000235:genetics*; D048348:Reverse Transcription
chemical_list: D018626:Retroelements; D012194:RNA-Directed DNA Polymerase