Glycerin fatty acid esters as a new lubricant of tablets.
Lubrication properties were compared among glycerin fatty acid esters (Poem TR-FB and Poem TR-HB), magnesium stearate (Mg-St), and a sucrose fatty acid ester (RYOTO SUGAR ESTER S-370F: SSE). Granules containing 50% acetaminophen were prepared, and improvements in their fluidity by the lubricants were compared. The lubricant effects of TR-FB and HB during tablet punching (pressure transmission ratio, ejection force) were similar to those of Mg-St and were better than those of SSE. When the lubricant content, mixing time, and tabletting pressure were changed, TR-FB and TR-HB provided better tablet hardness than Mg-St. TR-FB and TR-HB made tablets more disintegratable than Mg-St. When the effects of these lubricants on the stability of acetylsalicylic acid (ASA) were compared, Mg-St promoted its hydrolysis, but TR-FB or TR-HB did not affect its stability.
Aoshima
Hiroyuki
H
Department of Pharmaceutical Sciences, University of Shizuoka, 51-1 Yada, Shizuoka 422-8526, Japan.
Miyagisnima
Atsuo
A
Nozawa
Yasuo
Y
Sadzuka
Yasuyuki
Y
Sonobe
Takashi
T
D004952:Esters; D005227:Fatty Acids / Q000737:chemistry*; D005990:Glycerol / Q000737:chemistry*; D008153:Lubrication; D013607:Tablets
D004952:Esters; D005227:Fatty Acids; D013607:Tablets; D005990:Glycerol