Hypoxia inducible factor (HIF) in rheumatology: low O2! See what HIF can do!
Maintenance of oxygen homoeostasis is the basic principle in cell proliferation, differentiation, survival, and function in all higher organisms. The transcription factor, HIF (hypoxia inducible factor) has a central role in oxygen homoeostasis, and is indispensably linked to energy metabolism. Abnormally reduced oxygen concentrations leading to dysfunctional cell metabolism are found in rheumatoid arthritis and hence, knowledge of the molecular adaptive responses to hypoxia and the involvement of HIF in the pathogenesis of RA are interesting.
Gaber
T
T
Department of Rheumatology and Clinical Immunology, Charité University Hospital, Schumannstrasse 20/21, 10117 Berlin, Germany.
Dziurla
R
R
Tripmacher
R
R
Burmester
G R
GR
Buttgereit
F
F
D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D002358:Cartilage, Articular / Q000378:metabolism / Q000473:pathology; D015687:Cell Hypoxia / Q000502:physiology; D016572:Cyclosporine / Q000627:therapeutic use; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D000860:Hypoxia / Q000276:immunology / Q000378:metabolism; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008213:Lymphocyte Activation; D009389:Neovascularization, Pathologic; D009687:Nuclear Proteins / Q000737:chemistry / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D013583:Synovial Membrane / Q000276:immunology / Q000378:metabolism*; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D004268:DNA-Binding Proteins; C497442:HIF1A protein, human; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D007166:Immunosuppressive Agents; D009687:Nuclear Proteins; D014157:Transcription Factors; D042461:Vascular Endothelial Growth Factor A; D016572:Cyclosporine; D010100:Oxygen