title: In vivo 1H MR spectroscopy of thyroid carcinoma.
abstract: To determine if proton magnetic resonance spectroscopy (1H MRS) of thyroid carcinoma is feasible and to determine if 1H MRS spectra of malignant tumors differ from that of normal thyroid tissue. We performed 1H MRS at 1.5 T at echo-times (TE) 136 and 272 ms to examine eight patients with thyroid cancer (primary tumour or nodal metastasis) larger than 1 cm3 in size and five volunteers with normal thyroids. Spectra acquired from six primary tumors (three anaplastic carcinomas, two papillary carcinomas and one follicular carcinoma) and two nodes (two papillary carcinoma metastases) were analyzed in the time-domain using a non-linear least squares fitting algorithm with incorporation of prior knowledge. Choline (3.2 ppm) was identified in all solid carcinomas with a mean choline/creatine of 4.3 at TE 136 ms and 5.4 at TE 272 ms. Ratios for malignant tumors at TE 136 ms ranged from 1.6 in well differentiated follicular carcinoma to 9.4 in anaplastic carcinoma. No choline was detected in normal thyroid tissues. Our results showed that 1H MRS is a feasible technique for the evaluation of malignant thyroid tumors larger than 1 cm3 and that proton spectra of malignant tumors differ from that of normal thyroid tissue.
authors.affiliation: Department of Diagnostic Radiology and Organ Imaging, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, SAR China. b834756@mailserv.cuhk.hk
authors.forename: Ann D
authors.initials: AD
authors.lastname: King
authors.forename: David K W
authors.initials: DK
authors.lastname: Yeung
authors.forename: Anil T
authors.initials: AT
authors.lastname: Ahuja
authors.forename: Gary M K
authors.initials: GM
authors.lastname: Tse
authors.forename: Amy B W
authors.initials: AB
authors.lastname: Chan
authors.forename: Sherlock S L
authors.initials: SS
authors.lastname: Lam
authors.forename: Andrew C
authors.initials: AC
authors.lastname: van Hasselt
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000465:Algorithms; D002277:Carcinoma / Q000175:diagnosis* / Q000473:pathology; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016018:Least-Squares Analysis; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000473:pathology*
chemical_list: D003401:Creatine; D002794:Choline