Transcriptional activation: mediator can act after preinitiation complex formation.
The Mediator complex connects transcriptional activators bound at enhancers with RNA polymerase (Pol) II. demonstrate that Mediator also has an important role in transcriptional activation after recruitment of the Pol II machinery to promoters.
Struhl
Kevin
K
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA. kevin@hms.harvard.edu
D000107:Acetylation; D002843:Chromatin / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D017874:Immediate-Early Proteins / Q000378:metabolism; D020935:MAP Kinase Signaling System; D008745:Methylation; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012319:RNA Polymerase II / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism; D015533:Transcriptional Activation
D002843:Chromatin; D006657:Histones; D017874:Immediate-Early Proteins; D014157:Transcription Factors; D012319:RNA Polymerase II