A kinetic model for simulation of blood coagulation and inhibition in the intrinsic path.
A mathematical simulation pathway for the generation of thrombin has been developed with various assumptions made of kinetic rate laws and their summation for reactions involving the activation of factors VIII, IX, X and V and protein C in the formation of thrombin. The object of the computational modelling study is to stimulate the activation and inhibition of blood coagulation. The level of complexity and assumed parameters makes conclusions uncertain. However, an interesting outcome is that kinetic rates may show oscillation behavior under particular high levels of protein C feedback inhibition. The model, which permits the assessment of the reaction over a broad range of conditions, would defy quantitative practical use, but could have predictive value as a qualitative descriptor of coagulation.
Qiao
Y H
YH
Biomechanics & Medical Information Institute, Beijing University of Technology, Beijing 100022, PR China.
Liu
J L
JL
Zeng
Y J
YJ
D000818:Animals; D001777:Blood Coagulation / Q000502:physiology*; D001779:Blood Coagulation Factors / Q000378:metabolism*; D001790:Blood Physiological Phenomena; D003198:Computer Simulation; D005246:Feedback; D006801:Humans; D007700:Kinetics; D008657:Metabolic Clearance Rate; D008955:Models, Cardiovascular; D017711:Nonlinear Dynamics; D011486:Protein C / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D013917:Thrombin / Q000378:metabolism*
D001779:Blood Coagulation Factors; D011486:Protein C; D013917:Thrombin