title: Anti-Müllerian hormone: its role in follicular growth initiation and survival and as an ovarian reserve marker.
abstract: In this paper the role in the ovary of anti-Müllerian hormone (AMH), a member of the transforming growth factor-beta family of growth and differentiation factors, is reviewed. AMH has an inhibitory effect on primordial follicle recruitment and may also inhibit follicle-stimulating homone-dependent selection of follicles for dominance. In addition to its functional role in the ovary, AMH in serum is an excellent candidate marker as an indication of the ovarian reserve, not only in infertility clinic patients but also in women during and after cancer treatment.
authors.affiliation: Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands. a.themmen@erasmusmc.nl
authors.forename: Axel P N
authors.initials: AP
authors.lastname: Themmen
mesh_terms: D054304:Anti-Mullerian Hormone; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D015415:Biomarkers / Q000032:analysis*; D002454:Cell Differentiation; D005260:Female; D006023:Glycoproteins / Q000494:pharmacology*; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis*; D009095:Mullerian Ducts; D009369:Neoplasms / Q000188:drug therapy; D006080:Ovarian Follicle / Q000254:growth & development* / Q000502:physiology*; D013735:Testicular Hormones / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D006023:Glycoproteins; D013735:Testicular Hormones; D054304:Anti-Mullerian Hormone