Synthesis of 2-N,N-dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo[b,f]furo[2,3-d]oxepine derivatives as potential anxiolytic agents. Part 2: substitutions by methyl groups on the tetrahydrofuran ring.
New synthesis approaches that have led to a series of novel tetrahydrodibenzo[b,f]furo[2,3-d]oxepine derivatives are described. A systematic synthetic approach for the introduction of small carbon substituents (methyl groups) around the tetrahydrofuran moiety of tetrahydrodibenzo[b,f]furo[2,3-d]oxepine derivatives is reported. Preliminary pharmacological data of the newly synthesised compounds are also communicated.
Trabanco
Andrés A
AA
Johnson and Johnson Pharmaceutical Research and Development, Division of Janssen-Cilag S.A., Jarama 75, 45007 Toledo, Spain. atrabanc@prdes.jnj.com <atrabanc@prdes.jnj.com>
Alonso
José M
JM
Cid
José M
JM
Font
Luis Miguel
LM
Megens
Anton
A
D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001572:Benzofurans / Q000138:chemical synthesis* / Q000494:pharmacology; D001665:Binding Sites; D005663:Furans / Q000737:chemistry*; D010082:Oxepins / Q000138:chemical synthesis* / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D014151:Anti-Anxiety Agents; D001572:Benzofurans; D005663:Furans; D010082:Oxepins; C018674:tetrahydrofuran