Presence of tetracycline resistance determinants and susceptibility to tigecycline and minocycline.
No relation between the presence of tetracycline resistance determinants tet(A) to tet(E) and the MICs of tigecycline was observed for Enterobacteriaceae, although tetracycline-susceptible isolates were more susceptible overall to tigecycline, whereas the presence of tet(M) in Staphylococcus aureus was associated with higher MICs of minocycline.
Fluit
Ad C
AC
Eijkman-Winkler Institute, University Medical Center Utrecht, Room G04.614, P.O. Box 85500, 3508 GA Utrecht, The Netherlands. A.C.Fluit@lab.azu.nl
Florijn
Alice
A
Verhoef
Jan
J
Milatovic
Dana
D
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D004755:Enterobacteriaceae / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects; D013752:Tetracycline / Q000494:pharmacology; D013753:Tetracycline Resistance / Q000235:genetics; D000078304:Tigecycline
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D000078304:Tigecycline; D013752:Tetracycline; D008911:Minocycline