Brief communication: duration of platelet dysfunction after a 7-day course of Ibuprofen.
BACKGROUND
Despite a paucity of evidence, clinicians routinely advise that patients discontinue using nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, at least 1 week before most surgical procedures.


OBJECTIVE
To define the duration of ibuprofen-induced platelet dysfunction.


METHODS
Prospective cohort study.


METHODS
Denver/Aurora, Colorado.


METHODS
11 healthy adult volunteers.


METHODS
Individuals were tested at baseline and serially after completion of a 7-day course of ibuprofen (600 mg orally every 8 hours). The platelet function analyzer (PFA-100, Dade Behring, Newark, Delaware), a test that has replaced the bleeding time in many clinical settings, was used.


RESULTS
All participants exhibited normal platelet function before starting ibuprofen. Platelet dysfunction was apparent after completion of the ibuprofen course in 7 of the 11 participants and normalized by 24 hours after the last ibuprofen dose.


CONCLUSIONS
The sample size in this study was small, and no participants had a major illness. Correlation between PFA-100 results and clinical bleeding has not been established.


CONCLUSIONS
Platelet function seems to normalize within 24 hours after cessation of regular ibuprofen use in healthy individuals. Further studies are warranted to provide a rational basis for timing of NSAID withdrawal in a range of patients undergoing surgery.
Goldenberg
Neil A
NA
Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Health Sciences Center, Aurora, Colorado 80045-0507, USA. neil.goldenberg@uchsc.edu
Jacobson
Linda
L
Manco-Johnson
Marilyn J
MJ
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D003278:Contraceptives, Oral, Hormonal / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003278:Contraceptives, Oral, Hormonal; D007052:Ibuprofen