title: Discovery of powerful uranyl ligands from efficient synthesis and screening.
abstract: New tripodal gem-(bis-phosphonates) uranophiles were discovered by a screening method that allowed for the selection of ligands with strong uranyl-binding properties in a convenient microtiter-plate format. The method is based on competitive uranium binding by using Sulfochlorophenol S as chromogenic chelate. This dye compound was found to present high uranyl complexation properties and allowed to highlight ligands presenting association constants for UO(2+)(2) up to 10(18) at pH 7.4 and 10(20) at pH 9. A collection of 40 known ligands including polycarboxylate, hydroxamate, catecholate, hydroxypyridonate and hydroxyquinoline derivatives was tested. Also screened was a combinatorial library prepared from seven amine scaffolds and eight acrylates bearing diverse chelating moieties. Among these 96 tested candidates, a tripod derivative bearing gem-bis-phosphonates moieties was found to present the highest complexation properties over a wide range of pH and was further studied.
authors.affiliation: Service de Marquage Moléculaire et de Chimie Bio-organique, DBJC/DSV CEA-Saclay, Gif sur Yvette, France.
authors.forename: Marcin
authors.initials: M
authors.lastname: Sawicki
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Siaugue
authors.forename: Christophe
authors.initials: C
authors.lastname: Jacopin
authors.forename: Christophe
authors.initials: C
authors.lastname: Moulin
authors.forename: Théodorine
authors.initials: T
authors.lastname: Bailly
authors.forename: Ramon
authors.initials: R
authors.lastname: Burgada
authors.forename: Stéphane
authors.initials: S
authors.lastname: Meunier
authors.forename: Paul
authors.initials: P
authors.lastname: Baret
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Pierre
authors.forename: Frédéric
authors.initials: F
authors.lastname: Taran
mesh_terms: D006863:Hydrogen-Ion Concentration; D008024:Ligands; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D013450:Sulfones / Q000737:chemistry*; D014501:Uranium / Q000737:chemistry*
chemical_list: D008024:Ligands; D009281:Naphthalenes; D009942:Organometallic Compounds; D013450:Sulfones; C506869:sulfochlorophenol S; D014501:Uranium