title: [Preventive effects of montelukast on the collagen expression of pulmonary arterioles in rats with chronic hypoxia].
abstract: OBJECTIVE
  To evaluate the preventive effects of montelukast on the collagen expression of pulmonary arterioles in chronic hypoxic rats.
  
  
  METHODS
  Thirty male Wistar rats were randomly divided into three groups: control group, hypoxic group and montelukast preventive group. The animal model of pulmonary hypertension was established by exposing the rats to normabaric hypoxic conditions 8 hours q.d. for 3 weeks. The expression levels of collagen I and III in arterioles were observed by immunohistochemistry.
  
  
  RESULTS
  The positive degree of collagen I in pulmonary arterioles of hypoxic group was higher than that of control group (1.51+/-0.09 vs 1.15+/-0.05, P<0.01), and the positive degree of collagen I in pulmonary arterioles of preventive group (1.19+/-0.06) was lower than that of hypoxic group (P<0.01). The differences of positive degree of collagen III in pulmonary arterioles were not significant among the three groups (P>0.05).
  
  
  CONCLUSIONS
  Montelukast can reduce the hypoxia-induced deposition of collagen I in the pulmonary arterioles wall.
authors.affiliation: Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Xiao-ju
authors.initials: XJ
authors.lastname: Chen
authors.forename: De-yun
authors.initials: DY
authors.lastname: Cheng
authors.forename: Jian
authors.initials: J
authors.lastname: Guan
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiu-qiong
authors.initials: XQ
authors.lastname: Xia
mesh_terms: D000085:Acetates / Q000494:pharmacology*; D000818:Animals; D001160:Arterioles / Q000378:metabolism; D024042:Collagen Type I / Q000096:biosynthesis*; D003521:Cyclopropanes; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control; D000860:Hypoxia / Q000150:complications* / Q000378:metabolism; D020024:Leukotriene Antagonists / Q000494:pharmacology; D008297:Male; D011651:Pulmonary Artery / Q000378:metabolism*; D011804:Quinolines / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013440:Sulfides
chemical_list: D000085:Acetates; D024042:Collagen Type I; D003521:Cyclopropanes; D020024:Leukotriene Antagonists; D011804:Quinolines; D013440:Sulfides; C093875:montelukast