title: Effects of interleukin-6 produced in coronary circulation on production of C-reactive protein and coronary microvascular resistance.
abstract: We measured plasma levels of interleukin-6 and C-reactive protein at the orifice of the left coronary artery and at the great cardiac vein in patients who had coronary artery disease and those who had angiographically normal coronary arteries (controls). We also measured coronary microvascular resistance in the control group. We found increased levels of interleukin-6 in the coronary circulation of patients who had coronary artery disease compared with controls. This increase correlated with C-reactive protein production in the coronary circulation and coronary microvascular resistance. These findings suggest that a localized cytokine/inflammatory pathway functions in the coronary circulation and that interleukin-6 is involved in modulating coronary vascular tone.
authors.affiliation: First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan.
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Date
authors.forename: Takuroh
authors.initials: T
authors.lastname: Imamura
authors.forename: Takahiro
authors.initials: T
authors.lastname: Sumi
authors.forename: Tetsunori
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Junji
authors.initials: J
authors.lastname: Kawagoe
authors.forename: Hisamitsu
authors.initials: H
authors.lastname: Onitsuka
authors.forename: Riichirou
authors.initials: R
authors.lastname: Kawamoto
authors.forename: Toshiro
authors.initials: T
authors.lastname: Nagoshi
authors.forename: Tanenao
authors.initials: T
authors.lastname: Eto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000032:analysis* / Q000276:immunology; D003324:Coronary Artery Disease / Q000097:blood / Q000276:immunology* / Q000503:physiopathology; D003326:Coronary Circulation / Q000276:immunology; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D014655:Vascular Resistance / Q000276:immunology*
chemical_list: D015850:Interleukin-6; D002097:C-Reactive Protein