[Study of huchang qingfei pellets on immune function in rats infected with Mycoplasma pneumoniae].
OBJECTIVE
To study the effects and mechanism of Huchang Qingfei pellets on immune function in rats infected with mycoplasma pneumoniae.


METHODS
A rat model of mycoplasmal pneumonia (MP) was developed in repeated intranasal infectious routes and then the humoral and cellular immunocompetences were detected by radioimmunoassay, immune-turbidimetry and flow cytometry.


RESULTS
The levels of serum IgG,IgM and IL-2, IL-6 were enhinced obviously, the complement C3 and TNF-alpha were decreased and the ratio of CD4+ /CD8+ was improved significantly in the Huchang groups as compared with MP model group.


CONCLUSIONS
Huchang Qingfei pellets can reinforce immune function via preventing both cellular and humoral immunity from depression in the rats with MP.
Li
Ji-chang
JC
Heilongjiang Academy of Traditional Chinese Medicine Research Institute, Harbin 150036, China. lijichang828@sina.com
Wang
Wei-ming
WM
Zhang
Hong-juan
HJ
Dong
Long
L
D000818:Animals; D016516:CD4-CD8 Ratio; D003176:Complement C3 / Q000378:metabolism; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood; D007376:Interleukin-2 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D031238:Platycodon / Q000737:chemistry; D011019:Pneumonia, Mycoplasma / Q000097:blood / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar; D031364:Scutellaria baicalensis / Q000737:chemistry; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D003176:Complement C3; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007376:Interleukin-2; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha