title: Cystic neoplasms of the pancreas with mucin-production.
abstract: OBJECTIVE
  To compare the clinico-pathological features of intraductal papillary mucinous cystic tumours (IPMT) and mucinous cystic tumours (MCT) of the pancreas.
  
  
  METHODS
  Eighteen patients with IPMT and 18 with MCT who underwent surgical resection between 1990 and 2004 were retrospectively reviewed. Their clinico-pathological features were compared using univariate analysis. Statistical analyses of potential predictive factors of malignancy for each of these two groups were also conducted.
  
  
  RESULTS
  Patients with IPMT were found to be older (64+/-10 vs 43+/-18 years, p<0.001) and were predominantly male (male:female ratio, 5:4 vs 1:17, p=0.003) as compared to patients with MCT. MCTs were found in the body-tail region (100%) whereas IPMTs were more evenly distributed (50% in the head) (p=0.001). Pathologically, IPMT was distinct from MCT in terms of size (3.8+/-3.2 vs 9.1+/-4.4 cm, p=0.001), association with secondary pancreatitis (50 vs 0%, p=0.011), communication with the pancreatic duct (94 vs 0%, p<0.001), presence of a dilated main pancreatic duct (61 vs 0%, p<0.001) and the presence of ovarian-type stroma (0 vs 44%, p=0.003).
  
  
  CONCLUSIONS
  IPMT and MCT are distinct clinico-pathological entities. This distinction is important as management and outcome of these entities may differ.
authors.affiliation: Department of Surgery, Singapore General Hospital, Outram Road, Singapore 169608. bkgkp@hotmail.com
authors.forename: B K P
authors.initials: BK
authors.lastname: Goh
authors.forename: Y M
authors.initials: YM
authors.lastname: Tan
authors.forename: P C
authors.initials: PC
authors.lastname: Cheow
authors.forename: Y F A
authors.initials: YF
authors.lastname: Chung
authors.forename: P K H
authors.initials: PK
authors.lastname: Chow
authors.forename: W K
authors.initials: WK
authors.lastname: Wong
authors.forename: L L P J
authors.initials: LL
authors.lastname: Ooi
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D021441:Carcinoma, Pancreatic Ductal / Q000378:metabolism / Q000473:pathology*; D003536:Cystadenocarcinoma / Q000378:metabolism / Q000473:pathology*; D018282:Cystadenocarcinoma, Mucinous / Q000473:pathology; D018283:Cystadenocarcinoma, Papillary / Q000473:pathology; D003537:Cystadenoma / Q000378:metabolism / Q000473:pathology*; D018291:Cystadenoma, Mucinous / Q000473:pathology; D018292:Cystadenoma, Papillary / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009077:Mucins / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D010195:Pancreatitis / Q000150:complications
chemical_list: D009077:Mucins