title: Transfusion-associated graft-versus-host disease in an immunocompetent individual following cardiac surgery.
abstract: A 65-year-old man underwent coronary artery bypass graft surgery at our tertiary care hospital. Perioperatively, he was transfused with four units of nonirradiated whole blood from first-degree relatives and discharged from the hospital at postoperative day seven. He presented six days later with fever, skin rash, elevated liver enzymes, and progressive pancytopenia. Elevated bilirubin levels and diarrhea were added to the clinical picture over the following days. Clinical findings and results of a skin biopsy specimen were consistent with transfusion-associated graft-versus-host disease. The patient died 20 days after transfusion.
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Baskent University, Konya Medical and Research Center, Selcuklu/Konya, Turkey. kivancse@hotmail.com
authors.forename: Kivanc
authors.initials: K
authors.lastname: Serefhanoglu
authors.forename: Hale
authors.initials: H
authors.lastname: Turan
authors.forename: Tonguc
authors.initials: T
authors.lastname: Saba
authors.forename: Ismail
authors.initials: I
authors.lastname: Ozer
authors.forename: Emine
authors.initials: E
authors.lastname: Tosun
authors.forename: Hande
authors.initials: H
authors.lastname: Arslan
mesh_terms: D000368:Aged; D001026:Coronary Artery Bypass; D017809:Fatal Outcome; D006086:Graft vs Host Disease / Q000209:etiology*; D006801:Humans; D007121:Immunocompetence; D007430:Intraoperative Care; D008297:Male; D065227:Transfusion Reaction