Porous poly (DL-lactic acid) modified chitosan-gelatin scaffolds for tissue engineering.
Chitosan-gelatin (Cs-Gel) scaffolds are modified with poly (DL-lactic acid) (PDLLA) dichloromethane solution of different concentrations (0.1, 0.5, and 1.0%) and immersed in water after the evaporation of the solvent. The swollen scaffolds are freeze dried. The concentration of PDLLA has significant effects on both the physicomechanical properties and the cytocompatibility. Data reveal that only the 0.1% concentration could increase the tensile strength fourfold in comparison with the pristine Cs-Gel scaffold, while maintaining the human fibroblast adhesion, migration, and proliferation just like the Cs-Gel scaffold.
Liu
Haifeng
H
Research Institute of Polymeric Materials, Tianjin University, Tianjin 300072, China.
Yao
Fanglian
F
Zhou
Yutao
Y
Yao
Kangde
K
Mei
Dongrui
D
Cui
Lei
L
Cao
Yilin
Y
D000042:Absorption; D001672:Biocompatible Materials / Q000737:chemistry; D002448:Cell Adhesion / Q000502:physiology; D018929:Cell Culture Techniques / Q000379:methods*; D002465:Cell Movement / Q000502:physiology; D049109:Cell Proliferation; D002478:Cells, Cultured; D048271:Chitosan / Q000737:chemistry*; D004548:Elasticity; D005347:Fibroblasts / Q000166:cytology* / Q000502:physiology*; D005780:Gelatin / Q000737:chemistry*; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry*; D008422:Materials Testing; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D013718:Tensile Strength; D023822:Tissue Engineering / Q000379:methods*; D014867:Water / Q000737:chemistry
D001672:Biocompatible Materials; D011091:Polyesters; D011108:Polymers; D014867:Water; D019344:Lactic Acid; C033616:poly(lactide); D005780:Gelatin; D048271:Chitosan