title: Follicular lymphoid hyperplasia of the oral cavity representing progressive transformation of germinal center.
abstract: Follicular lymphoid hyperplasia (FLH) of the oral cavity is a rare and poorly understood lymphoproliferative disorder. We present a case of FLH of the oral cavity presenting with progressive transformation of germinal center (PTGC). The patient was a 49-year-old Japanese woman presenting with a hard mass in the right cheek. The resected specimen contained numerous lymphoid follicles with active germinal centers and a portion of the lymphoid follicles exhibited PTGC. The PTGCs contained a few large lymphoid cells resembling lymphocytic and histiocytic Reed-Sternberg cells of nodular lymphocyte-predominant Hodgkin lymphoma. The PTGC was surrounded by groups of epithelioid cells. In situ hybridization studies demonstrated strong expression of Epstein-Barr virus (EBV)-encoded small RNA in scattered large lymphoid cells in the PTGC. Although the etiology of FLH of the oral cavity remains unclear, the present case suggests that a subset of FLH of the oral cavity appears to be an EBV-associated lymphoproliferative disorder.
authors.affiliation: Department of Pathology and Clinical Laboratories, Gunma Cancer Center Hospital, Ohta 373-8550, Japan. mkojima@gunma-cc.jp
authors.forename: Masaru
authors.initials: M
authors.lastname: Kojima
authors.forename: Shigeo
authors.initials: S
authors.lastname: Nakamura
authors.forename: Misa
authors.initials: M
authors.lastname: Iijima
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshizumi
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Sakata
authors.forename: Nobuhide
authors.initials: N
authors.lastname: Masawa
mesh_terms: D049109:Cell Proliferation; D002472:Cell Transformation, Viral; D005260:Female; D018858:Germinal Center / Q000473:pathology / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D006965:Hyperplasia; D008198:Lymph Nodes / Q000473:pathology* / Q000821:virology; D008214:Lymphocytes / Q000821:virology; D008232:Lymphoproliferative Disorders / Q000473:pathology / Q000821:virology*; D008875:Middle Aged; D009059:Mouth Diseases / Q000473:pathology / Q000821:virology*; D012367:RNA, Viral / Q000032:analysis / Q000378:metabolism
chemical_list: D012367:RNA, Viral