Reductive effect of body weight in C57BL/6J mice fed a high-fat diet by Saesaengmyung Diet.
The Saesaengmyung Diet (SD) is a newly developed dietary product to help control weight. The aim of this study was to evaluate whether SD combined with a high-fat (HF) diet could influence body weight, fat accumulation, and glucose levels in blood. C57BL/6J mice were fed for 8 weeks with a standard diet, an HF diet, and an HF + 10% or HF + 20% SD diet. Body weight was recorded weekly, and plasma levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and glucose were analyzed at the end of the study. Weight increases in the 10% or 20% SD group were significantly less than in the HF diet group (p < 0.05). Plasma total cholesterol level significantly decreased by 33.5% in the 10% SD group and 38.8% in the 20% SD group, but the LDL cholesterol, HDL cholesterol, and glucose levels in the SD groups were not significantly changed. Our findings indicate that SD may be beneficial to overweight individuals in the reduction of weight gain induced by an HF diet.
An
Hyo-Jin
HJ
College of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea.
Kim
Na-Hyung
NH
Kim
Yun-Kyung
YK
Lyu
Yeoung-Su
YS
Shin
Taekyun
T
Hong
Seung-Heon
SH
Kim
Hyung-Min
HM
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D028321:Plant Preparations / Q000494:pharmacology*; D015431:Weight Loss
D001786:Blood Glucose; D004041:Dietary Fats; D028321:Plant Preparations; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase