Elevated pain threshold in eating disorders: physiological and psychological factors.
Several studies have found decreased pain sensitivity in patients with eating disorders but it is unclear what physiological and psychological factors are associated with this abnormality. In the present investigation, thermal pain threshold latency, somatoform dissociation, body image disturbance and physiological indices of autonomic neural system activity were measured in 39 female patients with eating disorders (21 with anorexia nervosa and 18 with bulimia nervosa) and 17 healthy women. Pain threshold was elevated in patients with eating disorders, especially those with binge-purging symptomatology. A regression analysis indicated that increased pain threshold is moderately associated with decreased peripheral skin temperature and weakly associated with lack of familiarity with one's own body. However, the between group differences in pain perception remained significant after controlling for peripheral skin temperature. Hence, elevation of pain threshold in eating disorders is a replicable finding, which is not explicable by peripheral indices of autonomic system activity or by somatoform dissociation. In future research it may be evaluated as a potential marker of broader phenotype of decreased interoceptive awareness, which may be associated with vulnerability to the development of eating disorders.
Papezová
H
H
Department of Psychiatry, 1st Faculty of Medicine, Eating Disorders Center, Charles University, Ke Karlovu 11, Prague 2, 12808 Prague, Czech Republic. hpap@seznam.cz
Yamamotová
A
A
Uher
R
R
D000328:Adult; D000856:Anorexia Nervosa / Q000150:complications* / Q000503:physiopathology*; D001341:Autonomic Nervous System / Q000502:physiology; D001828:Body Image; D002032:Bulimia / Q000150:complications* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D017288:Pain Threshold / Q000502:physiology* / Q000523:psychology*; D010641:Phenotype; D013001:Somatoform Disorders / Q000503:physiopathology; D013696:Temperature