title: Perforating disorder caused by salt-water application and its experimental induction.
abstract: BACKGROUND
  Perforating disorders are uncommon diseases characterized by transepidermal elimination histopathologically and include reactive perforating collagenosis, elastosis perforans serpiginosa, Kyrle's disease and perforating folliculitis. In addition, perforating disorders can develop in patients with diabetes mellitus, renal failure and even by accidental exposure of calcium salts.
  
  
  METHODS
  We report two cases of perforating disorder caused by chemical burn with commercially available salt-water application for self-treatment of chronic dermatitis or pruritus.
  
  
  RESULTS
  The commercially used salt water for making bean curd was analyzed and it consisted of calcium and other salts without harmful heavy metals. We induced a similar phenomenon by experimental application of commercial salt water on guinea pigs.
  
  
  CONCLUSIONS
  Bean curd is used as a food commonly in the Far-East, allowing a greater chance of exposure to salt water accidentally or occupationally. Bean curd is becoming more popular even in Western countries. To confirm causation, we induced a similar phenomenon in guinea pigs by experimental application of commercial salt water.
authors.affiliation: Department of Dermatology, Kyungpook National University Hospital, Daegu 700-721, Korea. seokjong@knc.ac.kr
authors.forename: S J
authors.initials: SJ
authors.lastname: Lee
authors.forename: J W
authors.initials: JW
authors.lastname: Jang
authors.forename: W C
authors.initials: WC
authors.lastname: Lee
authors.forename: D W
authors.initials: DW
authors.lastname: Kim
authors.forename: J B
authors.initials: JB
authors.lastname: Jun
authors.forename: H I
authors.initials: HI
authors.lastname: Bae
authors.forename: D J
authors.initials: DJ
authors.lastname: Kim
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology; D012965:Sodium Chloride / Q000009:adverse effects*; D013552:Swine
chemical_list: D012965:Sodium Chloride