title: P-cadherin expression in glandular lesions of the uterine cervix detected by liquid-based cytology.
abstract: OBJECTIVE
  To study P-cadherin aberrant expression as a possible marker for cervical adenocarcinomas in cytological samples.
  
  
  METHODS
  We studied P-cadherin immunoexpression in liquid-based cervical cytology samples of biopsy-proven cervical lesions.
  
  
  RESULTS
  We found a statistically significant correlation between P-cadherin expression and a cytological diagnosis of malignancy, either glandular or squamous (P < 0.0001). Twenty-two of 33 malignant cases showed P-cadherin membrane staining. None of the 30 benign cases tested showed membrane staining, but three of them displayed an aberrant nuclear P-cadherin expression.
  
  
  CONCLUSIONS
  We concluded that P-cadherin can be used to discriminate between malignant and benign cervical cytological specimens, but not to discriminate glandular from squamous lesions.
authors.affiliation: Pathology Division of Adolfo Lutz Institute, São Paulo, SP, Brazil.
authors.forename: A
authors.initials: A
authors.lastname: Longatto Filho
authors.forename: A
authors.initials: A
authors.lastname: Albergaria
authors.forename: J
authors.initials: J
authors.lastname: Paredes
authors.forename: M A R
authors.initials: MA
authors.lastname: Moreira
authors.forename: F
authors.initials: F
authors.lastname: Milanezi
authors.forename: F C
authors.initials: FC
authors.lastname: Schmitt
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D015820:Cadherins / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins