Novel variations in the signal peptide region of transforming growth factor beta1 gene in patients with hepatitis: a brief report from India.
Genotypic status of the signal peptide region of transforming growth factor beta1 (TGF-beta1) showed a significant difference in C/C-genotype frequency at +29 position (codon 10) between a range of viral hepatitis patients and controls (P = 0.009, OR = 3.15, CI = 1.29-7.678), contributed by those who were infected with hepatitis B virus (HBV) alone or HBV + hepatitis delta virus (HDV) (P = 0.003, OR = 5.0, CI = 1.78-13.97).
Gupta
V
V
National Centre of Applied Human Genetics, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Arora
R
R
Saha
A
A
Dhir
A
A
Kar
P
P
Bamezai
R
R
D020121:5' Untranslated Regions / Q000235:genetics; D000328:Adult; D003062:Codon / Q000235:genetics; D005260:Female; D006509:Hepatitis B / Q000235:genetics*; D003699:Hepatitis D / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D021382:Protein Sorting Signals / Q000235:genetics; D016212:Transforming Growth Factor beta / Q000235:genetics*; D053773:Transforming Growth Factor beta1
D020121:5' Untranslated Regions; D003062:Codon; D021382:Protein Sorting Signals; C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1