title: Clinical, cognitive and anatomical evolution from nonfluent progressive aphasia to corticobasal syndrome: a case report.
abstract: Recent clinical and pathological studies have suggested that frontotemporal lobar degeneration (FTLD) and corticobasal syndrome (CBS) show clinical and pathological overlap. We present four years of longitudinal clinical, cognitive and anatomical data in the case of a 56-year-old woman, AS, whose clinical picture evolved from FTLD to CBS. For the first three years, AS showed a progressive speech and language disorder compatible with a diagnosis of the nonfluent aphasia variant of FTLD. At year four, 10 years after her first symptom, AS developed the classical clinical signs of CBS, including alien limb phenomenon and dystonia. Voxel-based morphometry (VBM) applied to AS's four annual scans showed progression of atrophy from the inferior posterior frontal gyrus, to the left insula and finally to the medial frontal lobe. This case demonstrates the clinical overlap between FTLD and CBS and shows that the two can appear in the same patient at different stages of the disease in relation to the progression of anatomical damage.
authors.affiliation: Department of Neurology, University of California San Francisco, San Francisco, CA 94143-1207, USA. marilu@itsa.ucsf.edu
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Gorno-Tempini
authors.forename: Ryan C
authors.initials: RC
authors.lastname: Murray
authors.forename: Katherine P
authors.initials: KP
authors.lastname: Rankin
authors.forename: Michael W
authors.initials: MW
authors.lastname: Weiner
authors.forename: Bruce L
authors.initials: BL
authors.lastname: Miller
mesh_terms: D001039:Aphasia, Broca / Q000473:pathology* / Q000523:psychology*; D001072:Apraxias / Q000209:etiology / Q000523:psychology; D001479:Basal Ganglia / Q000473:pathology*; D001480:Basal Ganglia Diseases / Q000209:etiology / Q000523:psychology; D003071:Cognition / Q000502:physiology; D018450:Disease Progression; D004421:Dystonia / Q000209:etiology / Q000523:psychology; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D006236:Handwriting; D006801:Humans; D007807:Language Tests; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000473:pathology* / Q000523:psychology*; D009483:Neuropsychological Tests; D010591:Phantom Limb / Q000209:etiology / Q000523:psychology; D011597:Psychomotor Performance / Q000502:physiology; D013060:Speech / Q000502:physiology