title: Alkylation of magnesium sulfinates: a direct transformation of functionalized aromatic/heteroaromatic halides into sulfones.
abstract: [reaction: see text] Sulfinate alkylation is one of the conventional methods for sulfone synthesis. The alkylation of magnesium sulfinates, which are easily accessible via reactions of organomagnesium intermediates with sulfur dioxide, provides a convenient route for sulfone preparation. In this communication, we report a preliminary study of the alkylation of arylmagnesium sulfinates. An application of this reaction to directly transform functionalized aromatic/heteroaromatic halides into sulfones is also described.
authors.affiliation: Department of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, 900 Ridgebury Road, Ridgefield, Connecticut 06877, USA. jwu@rdg.boehringer-ingelheim.com
authors.forename: Jiang-Ping
authors.initials: JP
authors.lastname: Wu
authors.forename: Jonathan
authors.initials: J
authors.lastname: Emeigh
authors.forename: Xi-Ping
authors.initials: XP
authors.lastname: Su