IL-8 increases transmission of HIV type 1 in cervical explant tissue.
Interleukin-8 (IL-8) is the predominant cytokine expressed in the female genital tract of women with certain infectious/inflammatory conditions. IL-8 increased HIV-1 replication in T cells and to a greater extent in monocytes/macrophages in vitro. Physiological levels of IL-8 increased susceptibility to HIV-1 infection 5- to 8-fold in cervical explant tissues. Competitive inhibition of the IL-8 receptor CXCR2 with the small molecule inhibitor SB225002 resulted in a 45-70% decrease in cervical explant susceptibility to HIV-1 infection.
Narimatsu
Roberto
R
Department of Pathology, Stanford University School of Medicine, Stanford, California 94305-5629, USA.
Wolday
Dawit
D
Patterson
Bruce K
BK
D000163:Acquired Immunodeficiency Syndrome / Q000517:prevention & control / Q000635:transmission; D002584:Cervix Uteri / Q000821:virology*; D005260:Female; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D016209:Interleukin-8 / Q000494:pharmacology*; D010671:Phenylurea Compounds / Q000494:pharmacology; D023062:Receptors, Interleukin-8A / Q000502:physiology; D023063:Receptors, Interleukin-8B / Q000037:antagonists & inhibitors / Q000502:physiology; D014779:Virus Replication / Q000187:drug effects
D016209:Interleukin-8; D010671:Phenylurea Compounds; D023062:Receptors, Interleukin-8A; D023063:Receptors, Interleukin-8B; C112019:SB 225002