title: Cerylimycins [corrected] A and B: antibacterial triterpenes from the new species Tricholoma sp. AU1.
abstract: To new triterpenes, trichomycins A (1) and B (2), were purified from the new species Tricholoma sp. AU1 by activity-guided fractionation following their antibacterial activity. The two compounds were found to have a hitherto unreported triterpenoid skeleton. The structures and relative stereochemistry of 1 and 2 were determined through extensive 2D NMR spectroscopy, while the inhibitory activity of 1 and 2 against two Gram-positive and two Gram-negative bacteria and a mammalian cell line was determined.
authors.affiliation: Cerylid Biosciences, 576 Swan Street Richmond, Victoria, 3121, Australia.
authors.forename: Simon P B
authors.initials: SP
authors.lastname: Ovenden
authors.forename: Jin
authors.initials: J
authors.lastname: Yu
authors.forename: Jill
authors.initials: J
authors.lastname: Bernays
authors.forename: Soo San
authors.initials: SS
authors.lastname: Wan
authors.forename: Larissa J
authors.initials: LJ
authors.lastname: Christophidis
authors.forename: Gian
authors.initials: G
authors.lastname: Sberna
authors.forename: R Murray
authors.initials: RM
authors.lastname: Tait
authors.forename: Howard G
authors.initials: HG
authors.lastname: Wildman
authors.forename: Dominique
authors.initials: D
authors.lastname: Lebeller
authors.forename: Denis
authors.initials: D
authors.lastname: Platel
authors.forename: Tom W
authors.initials: TW
authors.lastname: May
authors.forename: Barbara M
authors.initials: BM
authors.lastname: Meurer-Grimes
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001315:Australia; D001487:Basidiomycota / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000900:Anti-Bacterial Agents; D014315:Triterpenes; C499930:trichomycin B; C499929:trichomycin A