Genetics of glycopeptide resistance in gram-positive pathogens.
Glycopeptide resistance in enterococci, first detected in 1986, has since spread worldwide and represents a major health problem. Importantly, it has been recently acquired by Staphylococcus aureus. We shall review the genetics which accounts for this successful dissemination and discuss the possible origins of the resistance genes.
Courvalin
Patrice
P
Department of Biology, University of California, San Diego, La Jolla, CA 92093, USA. pcourval@pasteur.fr
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D016983:Enterococcus / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D006020:Glycopeptides; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D020713:Vancomycin Resistance / Q000235:genetics
D000900:Anti-Bacterial Agents; D006020:Glycopeptides