Cardiolipin in energy transducing membranes.
Cardiolipin is a phospholipid located exclusively in energy transducing membranes such as the bacterial cytoplasmic membrane and the inner membrane of mitochondria. It plays both a structural and a functional role in many multimeric complexes associated with these membranes. The role of cardiolipin in higher order organization of components of the mitochondrial respiratory chain revealed by a combined molecular genetic and biochemical approach is described.
Mileykovskaya
E
E
Department of Biochemistry and Molecular Biology, University of Texas-Houston, Medical School, Houston, TX 77030, USA. Eugenia.Mileykovskaya@uth.tmc.edu
Zhang
M
M
Dowhan
W
W
D000818:Animals; D002308:Cardiolipins / Q000378:metabolism / Q000502:physiology*; D004579:Electron Transport; D007425:Intracellular Membranes / Q000378:metabolism / Q000502:physiology*; D046911:Macromolecular Substances / Q000378:metabolism; D008928:Mitochondria / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000737:chemistry / Q000502:physiology
D002308:Cardiolipins; D046911:Macromolecular Substances