title: CTX-M-10 linked to a phage-related element is widely disseminated among Enterobacteriaceae in a Spanish hospital.
abstract: CTX-M-10 has been widely disseminated among multiple clones of several species of Enterobacteriaceae, harboring seemingly different plasmids, for over a decade in Ramón y Cajal University Hospital, Madrid, Spain. Cloning and sequencing of a 12.2-kb DNA fragment from plasmid pRYCE21 from Klebsiella pneumoniae strain KP4aC revealed a novel phage-related element immediately upstream of bla(CTX-M-10) conserved among different CTX-M-10-producing strains. This is the first report showing an extended-spectrum-beta-lactamase gene linked to a phage-related element.
authors.affiliation: Servicio de Microbiología, Hospital Son Dureta, C. Andrea Doria No. 55, 07014 Palma de Mallorca, Spain. aoliver@hsd.es
authors.forename: Antonio
authors.initials: A
authors.lastname: Oliver
authors.forename: Teresa M
authors.initials: TM
authors.lastname: Coque
authors.forename: Diana
authors.initials: D
authors.lastname: Alonso
authors.forename: Aránzazu
authors.initials: A
authors.lastname: Valverde
authors.forename: Fernando
authors.initials: F
authors.lastname: Baquero
authors.forename: Rafael
authors.initials: R
authors.lastname: Cantón
mesh_terms: D000595:Amino Acid Sequence; D001435:Bacteriophages / Q000235:genetics*; D004755:Enterobacteriaceae / Q000145:classification / Q000201:enzymology / Q000235:genetics; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D006761:Hospitals; D006801:Humans; D007710:Klebsiella Infections / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000235:genetics / Q000821:virology; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics; D017422:Sequence Analysis, DNA; D013030:Spain; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D001618:beta-Lactamases