Origin of Aymaras from Bolivia and their relationship with other Amerindians according to HLA genes.
Aymara Amerindians from the Titicaca Lake Andean highlands are studied for HLA-A, HLA-B, HLA-DRB1 and HLA-DQB1 gene frequencies. Genetic distances, neighbour-joining and correspondence analyses are performed by using other Amerindian and worldwide populations (15384 chromosomes are studied). The HLA genetic profile of Aymaras is different from neighbouring and language-related Quechuas (Incas). Both Quechuas and Aymaras seem to present an HLA-DRB1*0901 high frequency, which is present in a very low frequency or absent in Mesoamericans (Mazatecans, Mayans) and most studied Amerindians. Moreover, it is observed a closer relatedness of Aymaras with Amerindians from the Amazon Basin and Chaco lowlands, compared to Quechuans.
Arnaiz-Villena
A
A
Department of Immunology, Universidad Complutense, Madrid, Spain. aarnaiz@med.ucm.es
Siles
N
N
Moscoso
J
J
Zamora
J
J
Serrano-Vela
J I
JI
Gomez-Casado
E
E
Castro
M J
MJ
Martinez-Laso
J
J
D044467:American Indian or Alaska Native / Q000235:genetics*; D001838:Bolivia; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans
D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II