title: Preoperative versus postoperative radiation therapy for soft-tissue sarcomas.
abstract: In this article, we report results from a retrospective consecutive series of 117 patients with soft-tissue sarcomas treated with adjuvant radiation and surgical resection at 2 associated institutions. Fifty-nine patients received preoperative radiation; 58 patients received postoperative radiation. Mean clinical follow-ups were 6.1 years and 8.4 years, respectively. Nineteen (32.2%) of 59 patients in the preoperative group and 17 (29.3%) of 58 patients in the postoperative group had wound complications (P = .89). Three (5.1%) of 59 sarcomas in the preoperative group and 7 (12.1%) of 58 sarcomas in the postoperative group recurred locally (P = .19). Improved local disease control and other potential advantages of using preoperative radiation make this a preferred adjuvant treatment.
authors.affiliation: Department of Orthopaedic Surgery, Walter Reed Army Medical Center, Washington, DC 20307, USA.
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Kuklo
authors.forename: H Thomas
authors.initials: HT
authors.lastname: Temple
authors.forename: Brett D
authors.initials: BD
authors.lastname: Owens
authors.forename: John
authors.initials: J
authors.lastname: Juliano
authors.forename: Richard B
authors.initials: RB
authors.lastname: Islinger
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Andejeski
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Frassica
authors.forename: B Hudson
authors.initials: BH
authors.lastname: Berrey
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011182:Postoperative Care / Q000379:methods; D011300:Preoperative Care / Q000379:methods; D011336:Probability; D011829:Radiation Dosage; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D018570:Risk Assessment; D012509:Sarcoma / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D012983:Soft Tissue Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D016019:Survival Analysis; D016896:Treatment Outcome