[The effect of vitamin-mineral supplementation on the level of MDA and activity of glutathione peroxidase and superoxide dismutase in blood of matched maternal-cord pairs].
The aim of the present study was to investigate the effect of VIBOVITmama (Polfa Kutno S.A.) supplementation on lipid peroxidation (MDA) and activity of superoxide dismutase (SOD) and selenium-dependent glutathione peroxidase (GPx) in blood of pregnant women and in umbilical cord blood of their children. It is shown, that MDA concentration in plasma increased during pregnancy in both studied groups; however in vitamin-mineral C supplemented women it was lower (p < 0.05) than in placebo (p < 0.005). In erythrocytes MDA level was within the same range in both groups, but in women taking vibovit it was (in late pregnancy) lower by 10% than in trimester I. Activity of GPx in red blood cells decreased during pregnancy. In placebo the fall was two-fold more intensive (16%) than in the supplemented group (p < 0.005). Activity of erythrocytes SOD slightly increased (5%) in placebo, whereas in the group taking the formula it decreased (4%) but not statistically significant. MDA level in plasma of cord blood was not modified by supplementation, but in red blood cells was lowered by 20% (97.3 nmol/gHb-supplemented vs 116.3 nmol/gHb-placebo) which was observed. In erythrocytes of umbilical cord blood activity of GPx was higher in newborns of women taking vibovit (31.9 U/gHb) than in the control group (29.7 U/gHb), whereas activity of SOD was similar. Our result suggested that vitamin-mineral supplementation of pregnant women improved antioxidant status in mothers and their children. It seems that in order to prevent oxidative damage VIBOVITmama formula can be recommended as a supplement diet in pregnant women.
Chełchowska
Magdalena
M
Zakład Biochemii i Diagnostyki Laboratoryjnej, Instytut Matki i Dziecka, Warszawie. lipidy@imid.med.pl
Laskowska-Klita
Teresa
T
Kubik
Paweł
P
Leibschang
Jerzy
J
D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D019587:Dietary Supplements; D004311:Double-Blind Method; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005312:Fetal Blood / Q000187:drug effects* / Q000378:metabolism; D016166:Free Radical Scavengers / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000097:blood / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D008315:Malondialdehyde / Q000097:blood*; D018384:Oxidative Stress / Q000187:drug effects; D011247:Pregnancy / Q000097:blood*; D011248:Pregnancy Complications / Q000188:drug therapy; D011295:Prenatal Care / Q000379:methods; D013482:Superoxide Dismutase / Q000097:blood / Q000187:drug effects*; D013997:Time Factors; D014131:Trace Elements / Q000008:administration & dosage / Q000494:pharmacology*; D014815:Vitamins / Q000008:administration & dosage / Q000494:pharmacology*
D000975:Antioxidants; D016166:Free Radical Scavengers; D014131:Trace Elements; D014815:Vitamins; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase