The search for novel drug leads for predominately antitumor therapies by utilizing mother nature's pharmacophoric libraries.
Recent advances in the use of natural products and compounds derivedfrom natural products as agents for the treatment of cancer and other diseases are reviewed. The antitumor agents discussed include tubulin interactive agents, inhibitors of topoisomerases I and II, caspase activators, proteasome inhibitors, histone deacetylase inhibitors, heat shock protein 90 inhibitors, protein kinase inhibitors, and inhibitors of hypoxia inducible factor 1. It can be concluded that, despite a perceived lack of popularity in recent years, the use of natural product scaffolds in searching for drug leads is still being practiced.
Kingston
David G I
DG
Virginia Polytechnic Institute and State University, Department of Chemistry, M/C 0212, Blacksburg, VA 24061, USA.
Newman
David J
DJ
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001685:Biological Factors / Q000627:therapeutic use*; D004268:DNA-Binding Proteins / Q000627:therapeutic use; D015195:Drug Design; D004790:Enzyme Induction / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D015723:Gene Library; D006360:Heat-Shock Proteins / Q000627:therapeutic use; D006801:Humans; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009687:Nuclear Proteins / Q000627:therapeutic use; D011494:Protein Kinases / Q000378:metabolism; D014157:Transcription Factors / Q000627:therapeutic use; D014404:Tubulin / Q000187:drug effects
D000970:Antineoplastic Agents; D001685:Biological Factors; D004268:DNA-Binding Proteins; D004791:Enzyme Inhibitors; C497442:HIF1A protein, human; D006360:Heat-Shock Proteins; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009687:Nuclear Proteins; D014157:Transcription Factors; D014404:Tubulin; D011494:Protein Kinases