Embolia cutis medicamentosa.
Embolia cutis medicamentosa or Nicolau syndrome is an acute necrotic condition of skin and subcutis that follows intramuscular administration of certain medicines. A young lady from rural area presented with an irregular-contoured ulceration with livedoid features on left deltoid region which she developed after receiving intramuscular injection of diclofenac sodium. The histopathological examination of the biopsied tissue demonstrated dead keratinocytes with degenerated epidermis and dermis. The condition improved on local management of wound with a residual scar.
Bajaj
Doulat Rai
DR
Department of Dermatology, Liaquat University of Medical & Health Sciences, Jamshoro. doulat01@yahoo.com
Qureshi
Aijaz Ahmed
AA
D000287:Administration, Topical; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004008:Diclofenac / Q000008:administration & dosage / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007273:Injections, Intramuscular / Q000009:adverse effects; D009336:Necrosis; D018570:Risk Assessment; D012883:Skin Ulcer / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology*; D034941:Upper Extremity
D000900:Anti-Bacterial Agents; D004008:Diclofenac