title: Change in perceived health and functioning over time in patients with type I diabetes mellitus.
abstract: OBJECTIVE
  The objective of this study was to investigate perceived health and functioning (PHF) of patients with type I diabetes mellitus (DMT1) over time and to compare change in perceived PHF with that of a sample of the general population.
  
  
  METHODS
  In a Dutch cohort of 234 patients with DMT1 we assessed PHF over time with two generic instruments: RAND-36 and EuroQol. We applied multilevel modelling to estimate change in PHF over the years 1995--2001. We compared change in PHF with change estimated from a comparably aged sample from the general population using a one-sample t-test.
  
  
  RESULTS
  Patients reported a significant decrease in PHF for most RAND-36 subscales. Mean changes in RAND-36 scores ranged from -0.09 (mental health) to -1.18 per year (bodily pain). EQ scores decreased significantly as well. Patients in the cohort had a faster decrease in three RAND-36 subscales and EQ-VAS over time than the estimated decrease in the general population.
  
  
  CONCLUSIONS
  This study showed that patients with DMT1 have a faster decrease in PHF over time than comparably aged persons from the general population. The generic instruments used in our study were sensitive enough to measure changes in PHF over time in an adult diabetes population.
authors.affiliation: Institute for Health Policy and Management, Erasmus Medical Centre, Rotterdam, The Netherlands. bertien.hart@planet.nl
authors.forename: Huberta E
authors.initials: HE
authors.lastname: Hart
authors.forename: William K
authors.initials: WK
authors.lastname: Redekop
authors.forename: Henk J G
authors.initials: HJ
authors.lastname: Bilo
authors.forename: Marc
authors.initials: M
authors.lastname: Berg
authors.forename: Betty Meyboom-de
authors.initials: BM
authors.lastname: Jong
mesh_terms: D000328:Adult; D015331:Cohort Studies; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009426:Netherlands