Synthesis and anticancer activity of novel 2-amino-4-(4-phenylpiperazino)- 1,3,5-triazine derivatives.
The synthesis and anticancer activity of novel 2-amino-4-(4-phenylpiperazino)-1,3,5-triazine derivatives 4a-b and 5a-f are described. Compounds 4a, 5a,c and 5f were evaluated by in vitro assays of growth inhibition against several human tumor cell lines. The vitro cytotoxic activity was found for 2-{2-amino-4-[4-(2-chlorophenyl)piperazino]- 1,3,5-triazin-6-yl}-3-(4-nitrophenyl)acrylonitrile (5f) (IC50 = 0.45 microM - 1.66 microM), whilst other tested compounds were inactive. Some of the molecular orbital calculations for the tested derivatives were also presented.
Pomarnacka
Elzbieta
E
Department of Chemical Technology of Drugs, Medical University of Gdańsk, 80-416 Gdańsk, Poland. zopom@farmacja.amg.gda.pl
Bednarski
Patrick
P
Grunert
Renate
R
Reszka
Przemysław
P
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007202:Indicators and Reagents; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D021281:Quantitative Structure-Activity Relationship; D013055:Spectrophotometry, Infrared; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology*
C500122:2-amino-4-(4-phenylpiperazino)-1,3,5-triazine; D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D010879:Piperazines; D014227:Triazines