title: Bisindigotin, a TCDD antagonist from the Chinese medicinal herb Isatis indigotica.
abstract: A new indigoid derivative, bisindigotin (1), with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-antagonistic activity was isolated from the ethanol extract of the Chinese medicinal herb Isatis indigotica. Its structure was determined by spectroscopic methods. In the human HepG2 hepatoma cell model, 1 (50 nM to 2 microM) was found to dose-dependently inhibit TCDD-induced ethoxyresorufin O-deethylase (EROD) activity.
authors.affiliation: Department of Biology, Hong Kong Baptist University, Kowloog Tong, Hong Kong, People's Republic of China.
authors.forename: Xiao Y
authors.initials: XY
authors.lastname: Wei
authors.forename: Chung Y
authors.initials: CY
authors.lastname: Leung
authors.forename: Chris K C
authors.initials: CK
authors.lastname: Wong
authors.forename: Xiao L
authors.initials: XL
authors.lastname: Shen
authors.forename: Ricky N S
authors.initials: RN
authors.lastname: Wong
authors.forename: Zong W
authors.initials: ZW
authors.lastname: Cai
authors.forename: Nai K
authors.initials: NK
authors.lastname: Mak
mesh_terms: D006528:Carcinoma, Hepatocellular; D019363:Cytochrome P-450 CYP1A1 / Q000378:metabolism; D006801:Humans; D031219:Isatis / Q000737:chemistry*; D008516:Medicine, Chinese Traditional; D008954:Models, Biological; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D000072317:Polychlorinated Dibenzodioxins / Q000037:antagonists & inhibitors*
chemical_list: D000072317:Polychlorinated Dibenzodioxins; D019363:Cytochrome P-450 CYP1A1