title: Treatment of cholesterol abnormalities.
abstract: Cardiovascular disease and its subset coronary heart disease are leading causes of morbidity and mortality in the United States and worldwide. In general, higher levels of low-density lipoprotein cholesterol are associated with an increased risk of coronary heart disease, myocardial infarction, and stroke. Reducing dietary fat can improve total cholesterol levels, but consequent reductions in cardiovascular outcomes are not well documented. The Mediterranean diet is the only dietary intervention associated with a reduction in all-cause mortality. Treatment with cholesterol-lowering medications decreases the rate of cardiovascular events, but a reduction in all-cause mortality with these agents has been found only in patients with pre-existing coronary heart disease. Drug treatment in patients with a history of heart disease and average-to-high cholesterol levels can decrease the risk for stroke. In patients with peripheral vascular disease, treatment of elevated cholesterol levels may slow disease progression.
authors.affiliation: Department of Familyi Medicine, UVA Health System, University of Virginia School of Medicine, Charlottesville 22908, USA.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Lockman
authors.forename: Andrea D
authors.initials: AD
authors.lastname: Tribastone
authors.forename: Karen V
authors.initials: KV
authors.lastname: Knight
authors.forename: John P
authors.initials: JP
authors.lastname: Franko
mesh_terms: D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control*; D004032:Diet; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications* / Q000178:diet therapy / Q000188:drug therapy*; D008019:Life Style
chemical_list: D000924:Anticholesteremic Agents