title: Urgency of micturition and detrusor contractility in men with prostatic obstruction and overactive bladders.
abstract: OBJECTIVE
  In men with prostatic obstruction and detrusor overactivity (DO), to ascertain whether urgency of micturition affects bladder contractility.
  
  
  METHODS
  We urodynamically assessed five groups of 20 men each who had bladder outflow obstruction (BOO) from benign prostatic enlargement-Groups 1 (with no DO and no urgency), 2 (with DO and no urgency), 3A (with DO and moderate urgency), 3B (with DO and severe urgency), and 4 (with DO, severe urgency and chronic ischemic cerebral lesions). Urgency was graded as moderate or severe by the ability to avert an urgent void at cystometry for > or =2 or <2 min, respectively. BOO was assessed by the "Abrams-Griffiths number" (AG) and bladder contractility by the parameters PIP and WF(max).
  
  
  RESULTS
  AG did not differ significantly in Groups 2, 3A, and 3B, proved higher in such groups than in Group 1, and was nearly the same in Groups 1 and 4. PIP and WF(max) were significantly higher in Groups 2, 3A, and 3B than in Groups 1 and 4, had the highest levels in Group 3B, and did not differ significantly in Groups 1-4 and 2-3A.
  
  
  CONCLUSIONS
  In DO patients with prostatic obstruction there seems to be a DO-related facilitation of bladder contractility. In the same patients, severe urgency of micturition might over-amplify (i.e., enhance a DO-related facilitation of) bladder contractility, provided there are no neurogenic (chronic ischemic cerebral) lesions.
authors.affiliation: Divisione di Urologia, Policlinico san Matteo, Pavia, Italy. c.cucchi1@virgilio.it
authors.forename: A
authors.initials: A
authors.lastname: Cucchi
authors.forename: S
authors.initials: S
authors.lastname: Quaglini
authors.forename: A
authors.initials: A
authors.lastname: Giannantoni
authors.forename: C
authors.initials: C
authors.lastname: Guarnaschelli
authors.forename: B
authors.initials: B
authors.lastname: Rovereto
mesh_terms: D000368:Aged; D006801:Humans; D008297:Male; D008875:Middle Aged; D009122:Muscle Hypertonia / Q000503:physiopathology*; D011469:Prostatic Diseases / Q000503:physiopathology*; D012044:Regression Analysis; D012189:Retrospective Studies; D012677:Sensation; D014549:Urinary Incontinence / Q000503:physiopathology*; D014563:Urodynamics