Signaling the junctions in gut epithelium.
This Perspective summarizes recent developments in our understanding of the signaling pathways involved in the regulation of epithelial cell adhesion in the gut. The role of phosphatidylinositol 3-kinase signaling in the modulation of adherens junctions, and the connections between tight junctions and nuclear transcription factors, are discussed. The effect of gastrins on adherens and tight junctions is presented as an example of the regulation of adhesion by growth factors. The consequences of dysregulation of adherens junctions and tight junctions for human pathology are also considered.
Hollande
Frédéric
F
Functional Genomics Institute (IGF), Cellular and Molecular Oncology Department, CNRS UMR5203/INSERMU661-UM1-UM2, Montpellier, France.
Shulkes
Arthur
A
Baldwin
Graham S
GS
D022005:Adherens Junctions / Q000502:physiology; D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D004847:Epithelial Cells / Q000502:physiology*; D005759:Gastroenteritis / Q000473:pathology; D005770:Gastrointestinal Neoplasms / Q000473:pathology; D006801:Humans; D007365:Intercellular Junctions / Q000502:physiology*; D007413:Intestinal Mucosa / Q000166:cytology*; D051379:Mice; D008954:Models, Biological; D051058:Oncogene Protein v-akt / Q000502:physiology; D036361:Peptide Hormones / Q000502:physiology; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D019108:Tight Junctions / Q000502:physiology
D036361:Peptide Hormones; D019869:Phosphatidylinositol 3-Kinases; D051058:Oncogene Protein v-akt