title: Unsuccessful treatment of extragenital lichen sclerosus with topical 1% pimecrolimus cream.
abstract: Lichen sclerosus most commonly affects the anogenital region. Spreading into the extragenital regions is rare, and its course is most commonly asymptomatic. Women have been reported to be affected 6 to 10 times more often than men. The etiology of lichen sclerosus is still unknown. The disease is characterized by ivory-white atrophic plaques, and no treatment ensuring complete recovery is available. T-cells are also involved in its pathogenesis. Pimecrolimus is a topical inhibitor of T-cells. In the present paper, we present a male patient with lichen sclerosus located only in extragenital regions and report an unsuccessful outcome of treatment with pimecrolimus 1% cream administered topically twice a day for 16 weeks.
authors.affiliation: Department of Dermatology, Kahramanmaras Sutcu Imam University, Faculty of Medicine, Kahramanmaras, Turkey.
authors.forename: Ozer
authors.initials: O
authors.lastname: Arican
authors.forename: Harun
authors.initials: H
authors.lastname: Ciralik
authors.forename: Sezai
authors.initials: S
authors.lastname: Sasmaz
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D001415:Back; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D006801:Humans; D018459:Lichen Sclerosus et Atrophicus / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009333:Neck; D012782:Shoulder; D016559:Tacrolimus / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D017211:Treatment Failure
chemical_list: D003879:Dermatologic Agents; C117268:pimecrolimus; D016559:Tacrolimus