title: Expression of the carcinoembryonic antigen gene is inhibited by SOX9 in human colon carcinoma cells.
abstract: The human carcinoembryonic antigen (CEA) is overexpressed in many types of human cancers and is commonly used as a clinical marker. In colon cancer, this overexpression protects cells against apoptosis and contributes to carcinogenesis. Therefore, CEA-expressing cells as well as CEA expression itself constitute potential therapeutic targets. In this report, we show that the transcription factor SOX9 down-regulates CEA gene expression and, as a probable consequence, induces apoptosis in the human colon carcinoma cell line HT29Cl.16E.
authors.affiliation: Institut de Génétique Humaine, Centre National de la Recherche Scientifique UPR1142, Montpellier, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Jay
authors.forename: Philippe
authors.initials: P
authors.lastname: Berta
authors.forename: Philippe
authors.initials: P
authors.lastname: Blache
mesh_terms: D017209:Apoptosis / Q000502:physiology; D002272:Carcinoembryonic Antigen / Q000096:biosynthesis / Q000235:genetics*; D002454:Cell Differentiation / Q000502:physiology; D003110:Colonic Neoplasms / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D015536:Down-Regulation / Q000502:physiology; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D019073:HT29 Cells; D006609:High Mobility Group Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D006801:Humans; D011401:Promoter Regions, Genetic; D055758:SOX9 Transcription Factor; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*
chemical_list: D002272:Carcinoembryonic Antigen; D006609:High Mobility Group Proteins; D055758:SOX9 Transcription Factor; C527932:SOX9 protein, human; D014157:Transcription Factors