title: Causes of severe chronic venous insufficiency.
abstract: A large number of adults in this country have some form of chronic venous insufficiency and a significant percentage of these have venous ulcers. The past decade has refined understanding of leukocyte-mediated injury and has elucidated the role of inflammatory processes in the dermal pathology of chronic venous insufficiency. Understanding of these pathologic cellular functions and molecular regulation of these processes is increasing.
authors.affiliation: Department of Surgery, Division of Vascular Surgery, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ 07103, USA.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Pappas
authors.forename: Brajesh K
authors.initials: BK
authors.lastname: Lal
authors.forename: Joaquim J
authors.initials: JJ
authors.lastname: Cerveira
authors.forename: Frank T
authors.initials: FT
authors.lastname: Padberg
authors.forename: Walter N
authors.initials: WN
authors.lastname: Duran
mesh_terms: D002908:Chronic Disease; D006801:Humans; D007866:Leg / Q000098:blood supply*; D012307:Risk Factors; D014689:Venous Insufficiency / Q000209:etiology* / Q000473:pathology