[Role of nitric oxide and lipid peroxidation in pathogenesis of acute experimental pancreatitis].
In experiment, conducted on 130 Wistar line rats, there was studied up the influence of nitric oxide on the peroxidal oxidation of lipids intensity, activity of enzymes of the antioxidant defense system and morphological changes in acute pancreatitis. Modern suggestions about the influence of the nitric oxide system on pathogenetic mechanisms of an acute pancreatitis and possibilities of correcting therapy were scrutinized. It was established, that the nitrates and the nitrites content in the blood serum of experimental animals correlates positively with the pancreatic oedema index and severity of its morphological changes as well. Intraperitoneal injection of 20% water solution of L-arginine in dosage 200 mg per 100 g of an animal body mass have had aggravated an acute pancreatitis course; intravenous injection of 1% water solution of methylene blue in dosage 1 mg per 100 g of an animal body mass caused pancreatoprotective effect.
Krivoruchko
I A
IA
Fedorovich
A A
AA
D000818:Animals; D001120:Arginine / Q000494:pharmacology; D004195:Disease Models, Animal; D015227:Lipid Peroxidation / Q000187:drug effects; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008751:Methylene Blue / Q000494:pharmacology; D009566:Nitrates / Q000097:blood; D009569:Nitric Oxide / Q000378:metabolism*; D009573:Nitrites / Q000097:blood; D019283:Pancreatitis, Acute Necrotizing / Q000209:etiology* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D008054:Lipid Peroxides; D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide; D001120:Arginine; D008751:Methylene Blue