title: Central corneal thickness correlated with glaucoma damage and rate of progression.
abstract: OBJECTIVE
  To evaluate whether the amount of glaucomatous optic nerve damage at presentation of the patient and the rate of progression of glaucoma during follow-up are related to central corneal thickness.
  
  
  METHODS
  The prospective observational clinical study included 861 eyes of 454 white subjects (239 normal eyes of 121 subjects, 250 ocular hypertensive eyes of 118 patients, 372 eyes of 215 patients with chronic open-angle glaucoma). For 567 eyes (304 patients) with ocular hypertension or chronic open-angle glaucoma, follow-up examinations were performed, with a mean follow-up time of 62.7 +/- 33.2 months (median, 60.8; range, 6.2-124.9). All patients underwent qualitative and morphometric evaluation of color stereo optic disc photographs and white-on-white visual field examination. Central corneal thickness was measured by corneal pachymetry.
  
  
  RESULTS
  Central corneal thickness correlated significantly (P < 0.001) and positively with the area of the neuroretinal rim and negatively with the loss of visual field. Development or progression of glaucomatous visual field defects detected in 119 (21.0%) eyes was statistically independent of central corneal thickness, in univariate (P = 0.99) and multivariate Cox regression analyses (P = 0.19).
  
  
  CONCLUSIONS
  At the time of patient referral, the amount of glaucomatous optic nerve damage correlated significantly with a thin central cornea. Progression of glaucomatous optic nerve neuropathy was independent of central corneal thickness, suggesting that central corneal thickness may not play a major role in the pathogenesis of progressive glaucomatous optic nerve damage.
authors.affiliation: Department of Ophthalmology and Eye Hospital, University Erlangen-Nürnberg, Erlangen, Germany. jost.jonas@augen.ma.uni-heidelberg.de
authors.forename: Jost B
authors.initials: JB
authors.lastname: Jonas
authors.forename: Andrea
authors.initials: A
authors.lastname: Stroux
authors.forename: Isabel
authors.initials: I
authors.lastname: Velten
authors.forename: Anselm
authors.initials: A
authors.lastname: Juenemann
authors.forename: Peter
authors.initials: P
authors.lastname: Martus
authors.forename: Wido M
authors.initials: WM
authors.lastname: Budde
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001837:Body Weights and Measures; D002648:Child; D002908:Chronic Disease; D003315:Cornea / Q000473:pathology*; D018450:Disease Progression; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D009798:Ocular Hypertension / Q000175:diagnosis / Q000503:physiopathology; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000503:physiopathology; D011446:Prospective Studies; D014065:Tonometry, Ocular; D014794:Visual Fields