title: Isolation of swinholide A and related glycosylated derivatives from two field collections of marine cyanobacteria.
abstract: [structure: see text] Chemical investigation of two field collections of marine cyanobacteria has led to the discovery of two new cytotoxic natural products, ankaraholides A (2) and B (3), along with the known compound swinholide A (1). Since swinholide-type compounds were previously localized to the heterotrophic bacteria of sponges, these findings raise intriguing questions about their true metabolic source.
authors.affiliation: College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, USA.
authors.forename: Eric H
authors.initials: EH
authors.lastname: Andrianasolo
authors.forename: Harald
authors.initials: H
authors.lastname: Gross
authors.forename: Douglas
authors.initials: D
authors.lastname: Goeger
authors.forename: Mirjam
authors.initials: M
authors.lastname: Musafija-Girt
authors.forename: Kerry
authors.initials: K
authors.lastname: McPhail
authors.forename: Rachel M
authors.initials: RM
authors.lastname: Leal
authors.forename: Susan L
authors.initials: SL
authors.lastname: Mooberry
authors.forename: William H
authors.initials: WH
authors.lastname: Gerwick
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000458:Cyanobacteria / Q000737:chemistry*; D005367:Fiji; D006031:Glycosylation; D008387:Marine Toxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013559:Symbiosis
chemical_list: D000970:Antineoplastic Agents; D008387:Marine Toxins; D011714:Pyrans; C506852:ankaraholide A; C506853:ankaraholide B; C086235:swinholide A