title: Bone ingrowth simulation for a concept glenoid component design.
abstract: Glenoid component loosening is the major problem of total shoulder arthroplasty. It is possible that uncemented component may be able to achieve superior fixation relative to cemented component. One option for uncemented glenoid is to use porous tantalum backing. Bone ingrowth into the porous backing requires a degree of stability to be achieved directly post-operatively. This paper investigates the feasibility of bone ingrowth with respect to the influence of primary fixation, elastic properties of the backing and friction at the bone prosthesis interface. Finite element models of three glenoid components with different primary fixation configurations are created. Bone ingrowth into the porous backing is modelled based on the magnitude of the relative interface micromotions and mechanoregulation of the mesenchymal stem cells that migrated via the bonded part of the interface. Primary fixation had the most influence on bone ingrowth. The simulation showed that its major role was not to firmly interlock the prosthesis, but rather provide such a distribution of load, that would result in reduction of the peak interface micromotions. Should primary fixation be provided, friction has a secondary importance with respect to bone ingrowth while the influence of stiffness was counter intuitive: a less stiff backing material inhibits bone ingrowth by higher interface micromotions and stimulation of fibrous tissue formation within the backing.
authors.affiliation: Faculty of Design, Engineering and Production, Delft University of Technology, Mekelweg 2, 2628 CD Delft, The Netherlands. a.andreykiv@wbmt.tudelft.nl
authors.forename: A
authors.initials: A
authors.lastname: Andreykiv
authors.forename: P J
authors.initials: PJ
authors.lastname: Prendergast
authors.forename: F
authors.initials: F
authors.lastname: van Keulen
authors.forename: W
authors.initials: W
authors.lastname: Swieszkowski
authors.forename: P M
authors.initials: PM
authors.lastname: Rozing
mesh_terms: D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003198:Computer Simulation; D017076:Computer-Aided Design; D004548:Elasticity; D019544:Equipment Failure Analysis / Q000379:methods; D005240:Feasibility Studies; D006801:Humans; D007595:Joint Prosthesis; D008422:Materials Testing; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology*; D008954:Models, Biological; D016348:Osseointegration / Q000502:physiology*; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology; D016062:Porosity; D011474:Prosthesis Design / Q000379:methods; D012785:Shoulder Joint / Q000503:physiopathology* / Q000601:surgery*; D013314:Stress, Mechanical; D013635:Tantalum / Q000737:chemistry*
chemical_list: D020099:Coated Materials, Biocompatible; D013635:Tantalum