[Manufacturing and stability of copper-histidine solution for treatment of Menkes' Kinky Hair Syndrome].
Menkes' Kinky Hair Syndrom is a rare, X-linked recessive multisystemic lethal disorder of copper metabolism. Male infants who are affected usually die at the age of 2-3 years. If the disease is diagnosed early, patients profit from subcutaneously administered copper salts. We describe the preparation and stability of a copper-histidin solution. This solution has some advantages in terms of stability over the solutions described in earlier publications. This is a great advantage for the patients and their parents, because an ambulatory care or a home care of this patients is possible now.
Hoppe-Tichy
T
T
Apotheke des Universitätsklinikums, Technische Universität Braunschweig, Germany. Torsten.Hoppe-Tichy@med.uni-heidelberg.de
Nguyen
T H
TH
Hentze
B W
BW
Lorke
M
M
D003300:Copper / Q000737:chemistry* / Q000627:therapeutic use; D004339:Drug Compounding; D004355:Drug Stability; D006639:Histidine / Q000737:chemistry* / Q000627:therapeutic use; D007700:Kinetics; D007706:Menkes Kinky Hair Syndrome / Q000188:drug therapy*; D019999:Pharmaceutical Solutions; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet
D019999:Pharmaceutical Solutions; D006639:Histidine; D003300:Copper