Cerebellar glioblastoma genetically defined as a secondary one.
We report here the case of a 29-year-old woman with cerebellar glioblastma. In the present case, tumor lesions were observed in each cerebellar hemisphere. The left-side lesion was diagnosed as glioblastoma, and the right-side lesion as malignant astrocytoma by histopathology. Immunohistochemistry revealed that the tumor cells of the left-side lesion was positive for p53, whereas epidermal growth factor receptors (EGFR) were negative in tumor cells from both sides. Genetic alterations were investigated using a genome DNA microarray (GenoSensor Array 300), which has led us to define this tumor as a secondary glioblastoma. The clinical presentation and genetic findings of this relatively rare entity are discussed.
Kawarabuki
K
K
Department of Neurosurgery, Fukuchiyama Municipal Hospital, Kyoto, Japan. bukky@h2.dion.ne.jp
Ohta
T
T
Hashimoto
N
N
Wada
K
K
Maruno
M
M
Yamaki
T
T
Ueda
S
S
D000328:Adult; D002528:Cerebellar Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D005260:Female; D005909:Glioblastoma / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D006801:Humans; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D020411:Oligonucleotide Array Sequence Analysis