title: The relationships between plasma total homocysteine and selected atherosclerotic risk factors according to the C677T methylenetetrahydrofolate reductase gene in Japanese.
abstract: BACKGROUND
  Variation of plasma total homocysteine (tHcy) levels among individuals is modified by 5,10-methylenetetrahydrofolate reductase (MTHFR) genotypes and selected atherosclerotic risk factors.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Healthy Japanese men (n=213) and women (n=242) aged 40-69 years were examined.
  
  
  RESULTS
  Serum uric acid, hemoglobin, hematocrit, serum creatinine, and men were independently significantly associated with plasma tHcy. The relationship between serum uric acid and plasma tHcy was the strongest in those with the mutant homozygote (VV), but the overall statistical test of interaction was not significant.
  
  
  CONCLUSIONS
  Serum uric acid, hematocrit, hemoglobin, creatinine, and men were determinants of plasma tHcy levels. Further investigations are needed.
authors.affiliation: Division of Health and Nutrition Monitoring, National Institute of Health and Nutrition, Tokyo, Japan. htay@nih.go.jp
authors.forename: Htay
authors.initials: H
authors.lastname: Lwin
authors.forename: Nobuo
authors.initials: N
authors.lastname: Yoshiike
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Kyoko
authors.initials: K
authors.lastname: Saito
authors.forename: Chigusa
authors.initials: C
authors.lastname: Date
authors.forename: Heizo
authors.initials: H
authors.lastname: Tanaka
mesh_terms: D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000453:epidemiology / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D003430:Cross-Sectional Studies; D005260:Female; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D005838:Genotype; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012016:Reference Values; D018570:Risk Assessment; D012680:Sensitivity and Specificity
chemical_list: D006710:Homocysteine; D042965:Methylenetetrahydrofolate Reductase (NADPH2)