Age-related neurodegenerative changes and how they affect the gut.
The enteric nervous system (ENS) is the division of the autonomic nervous system that regulates gastrointestinal (GI) function. Although large numbers of enteric neurons may be lost with age, the GI tract remains surprisingly functional. Exceptions to this generality include swallowing disorders and reduced colonic motility in the elderly. Evidence of age-related neurodegenerative changes in structure and function of the ENS is briefly reviewed in this Perspective.
Wade
Paul R
PR
Enterology Research Team, Johnson & Johnson Pharmaceutical Research and Development, L.L.C., Spring House, PA 19477, USA. pwade@prdus.jnj.com
Hornby
Pamela J
PJ
D000375:Aging / Q000502:physiology*; D000818:Animals; D031204:Caloric Restriction; D016923:Cell Death; D017615:Enteric Nervous System / Q000502:physiology*; D041981:Gastrointestinal Tract / Q000294:innervation* / Q000502:physiology*; D006801:Humans; D009130:Muscle, Smooth / Q000502:physiology; D019636:Neurodegenerative Diseases / Q000150:complications / Q000503:physiopathology*; D009474:Neurons / Q000473:pathology*; D051381:Rats