Free radical reactions and antioxidant activities of sesamol: pulse radiolytic and biochemical studies.
Sesamol (from Sesamum indicum) is a dietary compound, which is soluble in aqueous as well as lipid phases. Free radical scavenging reactions of sesamol, 5-hydroxy-1,3-benzodioxole, have been studied using a nanosecond pulse radiolysis technique. Sesamol efficiently scavenges hydroxyl, one-electron oxidizing, organo-haloperoxyl, lipid peroxyl, and tryptophanyl radicals. Its antioxidant activity has also been evaluated with cyclic voltammetry. In biochemical studies, it has been found to inhibit lipid peroxidation, hydroxyl radical-induced deoxyribose degradation, and DNA cleavage. These antioxidant and free radical scavenging activities of sesamol have been reported in the paper.
Joshi
Ravi
R
Radiation Chemistry & Chemical Dynamics Division, Chemistry Group, Bhabha Atomic Research Centre, Mumbai 400085, India. rjudrin@yahoo.com
Kumar
M Sudheer
MS
Satyamoorthy
K
K
Unnikrisnan
M K
MK
Mukherjee
Tulsi
T
D000975:Antioxidants / Q000494:pharmacology*; D052117:Benzodioxoles; D004247:DNA / Q000378:metabolism; D003855:Deoxyribose / Q000737:chemistry; D005290:Ferric Compounds / Q000737:chemistry; D005609:Free Radicals / Q000737:chemistry*; D015227:Lipid Peroxidation / Q000187:drug effects; D010545:Peroxides / Q000737:chemistry; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology*; D010957:Plasmids / Q000235:genetics; D011675:Pulse Radiolysis
D000975:Antioxidants; D052117:Benzodioxoles; D005290:Ferric Compounds; D005609:Free Radicals; D010545:Peroxides; D010636:Phenols; C049375:perhydroxyl radical; D003855:Deoxyribose; D004247:DNA; C025583:sesamol