Successive emergence of Enterobacter aerogenes strains resistant to imipenem and colistin in a patient.
Enterobacter aerogenes is an agent of hospital-acquired infection that exhibits a remarkable resistance to beta-lactam antibiotics during therapy. Five successive isolates of E. aerogenes infecting a patient and exhibiting a multiresistance phenotype to beta-lactam antibiotics and fluoroquinolones were investigated. Among these clinical strains, four presented resistant phenotypes during successive imipenem and colistin treatments. The involved resistance mechanisms exhibited by the successive isolates were associated with alterations of the outer membrane that caused a porin decrease and lipopolysaccharide modifications.
Thiolas
Aurélie
A
Enveloppe Bactérienne, Perméabilité et Antibiotiques, EA2197, IFR48, Faculté de Médecine, 27 Blvd. Jean Moulin, 13385 Marseille Cedex 05, France.
Bollet
Claude
C
La Scola
Bernard
B
Raoult
Didier
D
Pagès
Jean-Marie
JM
D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003091:Colistin / Q000494:pharmacology* / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D004359:Drug Therapy, Combination; D021902:Enterobacter aerogenes / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000188:drug therapy / Q000382:microbiology; D019143:Evolution, Molecular; D005260:Female; D006801:Humans; D015378:Imipenem / Q000494:pharmacology* / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D018272:Porins / Q000378:metabolism
D000900:Anti-Bacterial Agents; D018272:Porins; D015378:Imipenem; D003091:Colistin