title: Ruthenium-catalyzed regioselective 1,3-methylene transfer by cleavage of two adjacent sigma-carbon-carbon bonds: an easy and selective synthesis of highly substituted benzenes.
abstract: We report a new ruthenium-catalyzed 6-endo-dig cyclization of 6,6-cycloalkylidenyl-3,5-dien-1-ynes, which produces highly substituted benzenes with considerable structural reorganization. In this process, we observe a regioselective 1,3-methylene migration via extrusion from a cycloalkylidenyl ring, in addition to a regiocontrolled 1,2-alkyl migration. This cyclization provides an easy and convenient synthesis of complex benzenes bearing various different substituents.
authors.affiliation: Department of Chemistry, National Tsing-Hua University, Hsinchu, Taiwan, ROC.
authors.forename: Jian-Jou
authors.initials: JJ
authors.lastname: Lian
authors.forename: Arjan
authors.initials: A
authors.lastname: Odedra
authors.forename: Chang-Jung
authors.initials: CJ
authors.lastname: Wu
authors.forename: Rai-Shung
authors.initials: RS
authors.lastname: Liu