title: Herpetic whitlow as a harbinger of pediatric HIV-1 infection.
abstract: Herpetic whitlow applies to a primary or recurrent herpes simplex infection of the fingers. It is a rare condition in immunocompetent patients, and usually has a rapid evolution and prompt response to treatment. We report a 10-year-old girl referred to our department of infectious diseases with recurrent and unresponsive ulcerated and necrotic lesions of the fingers of both hands as a first sign of human immunodeficiency virus infection. Numerous instances of extensive or recurrent herpes lesions of the mouth, lips, and perianal areas have been found in the literature, but we have not found any report of periungual infection as a first manifestation of human immunodeficiency virus infection. Pediatricians and dermatologists need to be aware of this association in order to make an early diagnosis and start treatment of these patients' disease.
authors.affiliation: Department of Dermatology, Bambino Gesu Children's Hospital- Research Institute, Rome, Italy. elhachem@opbg.net
authors.forename: M
authors.initials: M
authors.lastname: El Hachem
authors.forename: S
authors.initials: S
authors.lastname: Bernardi
authors.forename: L
authors.initials: L
authors.lastname: Giraldi
authors.forename: A
authors.initials: A
authors.lastname: Diociaiuti
authors.forename: P
authors.initials: P
authors.lastname: Palma
authors.forename: G
authors.initials: G
authors.lastname: Castelli-Gattinara
mesh_terms: D000747:Anemia, Hypochromic / Q000188:drug therapy / Q000209:etiology; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D002648:Child; D005260:Female; D005385:Fingers / Q000473:pathology*; D015658:HIV Infections / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D015497:HIV-1 / Q000187:drug effects / Q000302:isolation & purification; D006229:Hand Dermatoses / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D007970:Leukopenia / Q000188:drug therapy / Q000209:etiology; D008231:Lymphopenia / Q000188:drug therapy / Q000209:etiology; D009336:Necrosis; D016896:Treatment Outcome; D014456:Ulcer
chemical_list: D044966:Anti-Retroviral Agents