title: [Epidemiological and clinical aspects of paediatric HIV infections in Albert-Royer Paediatric Hospital (Dakar, Senegal)].
abstract: Human Immunodeficiency Virus (HIV) infection prevalence rate is estimated at 1.4% in Senegal, and about 3,000 children could be infected. HIV positive children are followed up since 2000 in Albert Royer Hospital (Dakar, Senegal).
  
  
  OBJECTIVE
  To describe clinical and epidemiological aspects of HIV paediatric infection, and to evaluate the implementation of high active antiretroviral therapy in HIV positive children in our country.
  
  
  METHODS
  Over a period of three years, the medical reports of 98 infected patients have been collected, 96% with HIV 1 infection.
  
  
  RESULTS
  Most of the patients had a maternally transmitted HIV infection (99%). At their enrollment, the median age was 60 months; malnutrition (79%), persistent lymphadenopathy (65%) and skin lesions (64%) were the common clinical manifestations. Thirty-nine percent of the patients were in class C (CDC) and 81% had CD4 cell count< or =25%. Median viral load were 421,852 copies/ml at presentation. Seven infants had a rapid progressive disease with encephalopathy. Thirty-six patients received high active antiretroviral therapy with high observance and good tolerance.
  
  
  CONCLUSIONS
  This study allowed to define clinical and biological profile of paediatric HIV infection in our country and to update the implementation of high active antiretroviral therapy.
authors.affiliation: Centre hospitalier national d'enfants Albert-Royer, CHU de Fann, BP 25755, Dakar-Fann, Sénégal. haroyer@refer.sn
authors.forename: A
authors.initials: A
authors.lastname: Diack MBaye
authors.forename: H
authors.initials: H
authors.lastname: Signaté Sy
authors.forename: N R
authors.initials: NR
authors.lastname: Diagne Guèye
authors.forename: A
authors.initials: A
authors.lastname: Ba
authors.forename: A
authors.initials: A
authors.lastname: Sylla
authors.forename: S
authors.initials: S
authors.lastname: Diouf
authors.forename: I
authors.initials: I
authors.lastname: Diagne
authors.forename: M
authors.initials: M
authors.lastname: Sarr
authors.forename: H D
authors.initials: HD
authors.lastname: Sow
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology*; D006776:Hospitals, Pediatric; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D012675:Senegal