Effect of small-sized liposomal Adriamycin administered by various routes on a metastatic breast cancer model.
The antitumor effects of small-sized liposomal Adriamycin (LADR) administered by various routes were investigated in rabbits bearing well-developed VX2 tumors in the mammary gland. Rabbits received s.c. or i.v., or s.c. combined with i.v., injections of LADR 6 weeks after tumor implantation. The i.v. route showed a significant inhibitory effect on breast tumors and distant metastases. In comparison, metastases in axillary and mediastinal lymph nodes were more efficiently inhibited after s.c. injection. LADR administered concurrently by both the i.v. and s.c. routes produced satisfactory therapeutic activities on both primary breast tumors and metastases in local-regional lymph nodes, lungs and liver, as shown by slowed growth rates, decreased mRNA expression of proliferating cell nuclear antigen, and extensive necrosis and apoptosis of tumor cells. It is concluded that small-sized LADR administered s.c. provides reliable efficacy on lymphatic metastases of breast cancer and that the addition of treatment by the s.c. route to that by the conventional i.v. route can be recommended as a promising procedure to enhance chemotherapeutic effects in patients with metastatic breast cancer.
Chen
J-H
JH
Department of Vascular and Endocrine Surgery, First Affiliated Hospital of the Fourth Military Medical University, Xi'an, Shaanxi Province, China. chenjh@fmmu.edu.cn
Ling
R
R
Yao
Q
Q
Li
Y
Y
Chen
T
T
Wang
Z
Z
Li
K-Z
KZ
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D017209:Apoptosis / Q000187:drug effects; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000008:administration & dosage*; D004333:Drug Administration Routes; D005260:Female; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008081:Liposomes; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008207:Lymphatic Metastasis / Q000517:prevention & control; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D009336:Necrosis; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D011817:Rabbits; D014407:Tumor Cells, Cultured
D000903:Antibiotics, Antineoplastic; D008081:Liposomes; D018809:Proliferating Cell Nuclear Antigen; D004317:Doxorubicin