Effects of deltamethrin on granule cell migration during postnatal development of rat cerebellum.
Deltamethrin (DLT; 0.7mg/kg/body wt/day, i.p., dissolved in propylene glycol) administration during postnatal days 913 in Albino rat pups, resulted in a delayed appearance of radial glial fibers, that guide the migration of granule cells. Moreover, the radial glial fibers in the DLT-treated pups were disorganized, hypertrophied and heavily stained. Thus, it is being proposed that although after exposure to DLT the neuronal proliferation occurs at normal rate, the neuronal migration along the stumpy and crumpled radial fibers hamper the journey of the healthy neurons to their proper destination.
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Nisha
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Neuroscience Centre, School of Studies in Zoology, Jiwaji University, Gwalior 474 011, India. nishapatro@rediffmail.com
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D000818:Animals; D000831:Animals, Newborn; D002465:Cell Movement / Q000187:drug effects*; D002531:Cerebellum / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D007150:Immunohistochemistry; D007306:Insecticides / Q000633:toxicity*; D009457:Neuroglia / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D009570:Nitriles; D011722:Pyrethrins / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
D005904:Glial Fibrillary Acidic Protein; D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; C017180:decamethrin