title: Lancifodilactone F: a novel nortriterpenoid possessing a unique skeleton from Schisandra lancifolia and its anti-HIV activity.
abstract: [structures: see text] Lancifodilactone F (1), possessing an unprecedented rearranged pentanortriterpenoid backbone derived from cycloartane, was isolated from the leaves and stems of Schisandra lancifolia (Rehd. et Wils) A. C. Smith. Its structure was established by comprehensive NMR and MS spectroscopic analysis, coupled with single-crystal X-ray experiment. Compound 1 exerted minimal cytotoxicity against C8166 cells (CC50 > 200 microg/mL) and showed anti-HIV activity with EC50 = 20.69 +/- 3.31 microg/mL and a selectivity index > 6.62.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, P R China.
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Rong-Tao
authors.initials: RT
authors.lastname: Li
authors.forename: Sheng-Hong
authors.initials: SH
authors.lastname: Li
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Li
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
authors.forename: Rui-Rui
authors.initials: RR
authors.lastname: Wang
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
authors.forename: Cheng
authors.initials: C
authors.lastname: Wang
authors.forename: Qi-Tai
authors.initials: QT
authors.lastname: Zheng
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D032141:Schisandra / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D004365:Drugs, Chinese Herbal; D014315:Triterpenes; C506846:lancifodilactone F