title: A comparative evaluation of inhaled halothane, isoflurane, and sevoflurane during acute normovolemic hemodilution in dogs.
abstract: The hemodynamic response to acute normovolemic hemodilution (ANH) can be affected by the anesthetics used. We randomized 18 mongrel dogs to undergo ANH with 3 different inhaled anesthetics: halothane, isoflurane, or sevoflurane. Hemodynamics, oxygen transport, and gastric pH were measured before blood withdrawal, at the end of hemodilution, and 30 and 60 min after the end of hemodilution. The baseline measurements of all hemodynamic variables were similar among groups, with the exception of heart rate, which was more rapid in the sevoflurane group. Thirty minutes after hemodilution, the cardiac index increased 88%, 86%, and 157% in the halothane, isoflurane, and sevoflurane groups, respectively, whereas arterial-venous oxygen differences and oxygen consumption were larger in the halothane group compared with the isoflurane and sevoflurane groups. Gastric pH obtained by tonometry did not change and was not different among groups. Because the hemodynamic response to ANH was not blunted, all three anesthetics may be safely used for the maintenance of anesthesia.
authors.affiliation: *Department of Surgery, School of Veterinary Medicine, University of São Paulo, São Paulo, Brazil; and †Department of Anesthesiology, School of Medicine, University of São Paulo, São Paulo, Brazil.
authors.forename: Denise Tabacchi
authors.initials: DT
authors.lastname: Fantoni
authors.forename: Denise Aya
authors.initials: DA
authors.lastname: Otsuki
authors.forename: Aline Magalhães
authors.initials: AM
authors.lastname: Ambrósio
authors.forename: Eunice Yuriko
authors.initials: EY
authors.lastname: Tamura
authors.forename: José Otávio Costa
authors.initials: JOC
authors.lastname: Auler
mesh_terms: D000465:Algorithms; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001835:Body Weight / Q000502:physiology; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D005744:Gastric Acid / Q000378:metabolism; D006221:Halothane / Q000008:administration & dosage / Q000494:pharmacology*; D006438:Hemodilution; D006439:Hemodynamics / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D006895:Hydroxyethyl Starch Derivatives; D007530:Isoflurane / Q000008:administration & dosage / Q000494:pharmacology*; D008738:Methyl Ethers / Q000008:administration & dosage / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood; D010952:Plasma Substitutes; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D006895:Hydroxyethyl Starch Derivatives; D008738:Methyl Ethers; D010952:Plasma Substitutes; D000077149:Sevoflurane; D007530:Isoflurane; D010100:Oxygen; D006221:Halothane