title: [Observing the distribution of Annexin I and cPLA2 in the palatal process of mice by immunohistochemical staining].
abstract: OBJECTIVE
  To observe the distribution of Annexin I and cytosolic phospholipose A2 (cPLA2) in the palatal process of dexamethasome teratogenerated mice.
  
  
  METHODS
  Cutting along the coronary plane of the heads of fetal mice to obtain palate in the 14th, 15th, 16th day of gestation by 10-week-old in-bred mice. The distribution of Annexin I and cPLA2 was checked by immunohistochemical staining.
  
  
  RESULTS
  During the fusing of the palatal processes, the staining of Annexin I and cPLA2 was positive in the epithelial and mesenchymal cells of the palatal process, and the intensity of staining changed with time.
  
  
  CONCLUSIONS
  Annexin I and cPLA2 can modulate the development of fetal palate to some extent, and they may be important mediators in the development of cleft palate induced by dexamethasone.
authors.affiliation: Key Laboratory of Oral Biomedical Engineering of Ministry of Education, Sichuan University, Chengdu 610041, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Bing
authors.initials: B
authors.lastname: Shi
authors.forename: Hui
authors.initials: H
authors.lastname: Zuo
authors.forename: Lei
authors.initials: L
authors.lastname: Huang
mesh_terms: D000818:Animals; D017305:Annexin A1; D002972:Cleft Palate; D003907:Dexamethasone; D005938:Glucocorticoids; D051379:Mice; D013194:Staining and Labeling
chemical_list: D017305:Annexin A1; D005938:Glucocorticoids; D003907:Dexamethasone