Bisindigotin, a TCDD antagonist from the Chinese medicinal herb Isatis indigotica.
A new indigoid derivative, bisindigotin (1), with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-antagonistic activity was isolated from the ethanol extract of the Chinese medicinal herb Isatis indigotica. Its structure was determined by spectroscopic methods. In the human HepG2 hepatoma cell model, 1 (50 nM to 2 microM) was found to dose-dependently inhibit TCDD-induced ethoxyresorufin O-deethylase (EROD) activity.
Wei
Xiao Y
XY
Department of Biology, Hong Kong Baptist University, Kowloog Tong, Hong Kong, People's Republic of China.
Leung
Chung Y
CY
Wong
Chris K C
CK
Shen
Xiao L
XL
Wong
Ricky N S
RN
Cai
Zong W
ZW
Mak
Nai K
NK
D006528:Carcinoma, Hepatocellular; D019363:Cytochrome P-450 CYP1A1 / Q000378:metabolism; D006801:Humans; D031219:Isatis / Q000737:chemistry*; D008516:Medicine, Chinese Traditional; D008954:Models, Biological; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D000072317:Polychlorinated Dibenzodioxins / Q000037:antagonists & inhibitors*
D000072317:Polychlorinated Dibenzodioxins; D019363:Cytochrome P-450 CYP1A1