Transforming growth factor-beta-1 variants are not associated with chronic nonalcoholic pancreatitis.
BACKGROUND
Pancreatic fibrosis is a key pathological feature of chronic pancreatitis. In vivo and in vitro data have demonstrated that pancreatic stellate cells (PSC) play a central role in pancreatic fibrosis. PSC activation and collagen synthesis are highly controlled by transforming growth factor-beta-1 (TGF-beta1). We evaluated whether functionally relevant genetic variants of TGF-beta1 are associated with chronic nonalcoholic pancreatitis.


METHODS
The promotor as well as exon 1 variants of the TGF-beta1 gene (G-800A, Leu10Pro and Arg25Pro) were investigated. Forty-two CP patients with a family history of nonalcoholic chronic pancreatitis (group A) and 88 patients without a family history of nonalcoholic chronic pancreatitis (group B) were studied. One hundred blood donors served as controls (group C).


RESULTS
The allelic frequencies of G-800A, Leu10Pro and Arg25Pro were 12, 38 and 6% in group A; 7, 40 and 6% in group B and 12, 29 and 3% in group C, respectively. The differences were not significant.


CONCLUSIONS
Functionally relevant genetic variants of the TGF-beta1 gene are not associated with nonalcoholic chronic pancreatitis.
Böhm
Kerstin
K
Medizinische Klinik und Poliklinik II, Universitat Leipzig, Leipzig, Germany.
Teich
Niels
N
Hoffmeister
Albrecht
A
Mössner
Joachim
J
Keim
Volker
V
Bödeker
Hans
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D010195:Pancreatitis / Q000235:genetics*; D011110:Polymorphism, Genetic; D016212:Transforming Growth Factor beta / Q000235:genetics*
D016212:Transforming Growth Factor beta