Mutations in the tyrosine kinase domain of the epidermal growth factor receptor in non-small cell lung cancer.
We evaluated somatic genetic alterations in the kinase domain of the EGFR gene in the tumors of 219 non-small cell lung cancer patients of primarily Caucasian and African American origins. We identified 26 patients (12%) whose tumors had a mutation in the EGFR gene, and 11 (5%) patients carried novel genomic variations consistent with germ-line polymorphisms. All but one mutation were identified in Caucasian patients affected with adenocarcinoma. EGFR mutations were more frequent in women and in nonsmokers, but a significant portion of the affected patients were men (12 of 26) and current or past smokers accounted for half of the patients affected (13 of 26). Screening subjects with EGFR mutations may identify patients whose tumors could respond to targeted therapy using tyrosine kinase inhibitors.
Yang
Sei Hoon
SH
Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute/NIH, 41 Library Drive, Bethesda, MD 20892, USA.
Mechanic
Leah E
LE
Yang
Ping
P
Landi
Maria Teresa
MT
Bowman
Elise D
ED
Wampfler
Jason
J
Meerzaman
Daoud
D
Hong
Kyeong Man
KM
Mann
Felicia
F
Dracheva
Tatiana
T
Fukuoka
Junya
J
Travis
William
W
Caporaso
Neil E
NE
Harris
Curtis C
CC
Jen
Jin
J
D000230:Adenocarcinoma / Q000235:genetics*; D000328:Adult; D001741:Black or African American; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D017434:Protein Structure, Tertiary; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D012907:Smoking; D044465:White People
D066246:ErbB Receptors; D011505:Protein-Tyrosine Kinases