Keeping DCs awake by putting SOCS1 to sleep.
It has recently been shown that small interfering RNA (siRNA)-mediated inhibition of suppressors of cytokine signalling 1 (SOCS1) function enhances the immunostimulatory capacity of dendritic cells (DCs), which leads to more effective cancer vaccination. This recent study demonstrates the importance of negative regulation of DC maturation and functions for DC-based immunotherapy.
Kobayashi
Takashi
T
Molecular and Cellular Immunology Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Yoshimura
Akihiko
A
D000818:Animals; D017951:Antigen Presentation; D019496:Cancer Vaccines / Q000276:immunology; D002352:Carrier Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D020868:Gene Silencing; D051379:Mice; D018345:Mice, Knockout; D009374:Neoplasms, Experimental / Q000235:genetics / Q000276:immunology / Q000628:therapy; D034741:RNA, Small Interfering / Q000235:genetics / Q000494:pharmacology; D012097:Repressor Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology*; D000071222:Suppressor of Cytokine Signaling 1 Protein; D050826:Suppressor of Cytokine Signaling Proteins; D013601:T-Lymphocytes / Q000276:immunology
D019496:Cancer Vaccines; D002352:Carrier Proteins; D034741:RNA, Small Interfering; D012097:Repressor Proteins; C491590:Socs1 protein, mouse; D000071222:Suppressor of Cytokine Signaling 1 Protein; D050826:Suppressor of Cytokine Signaling Proteins