title: Headspace water-based liquid-phase microextraction.
abstract: A new organic-free mode of headspace liquid-phase microextraction termed headspace water-based liquid-phase microextraction has been developed. Five phenols were used as model compounds in the development and evaluation of the procedure. Parameters affecting the extraction efficiency were investigated. Under optimal extraction conditions, very high enrichment factors were achieved. Since only water (with sodium hydroxide to adjust the pH) and a conventional microsyringe were used, this new technique is affordable, efficient, and convenient for extraction of volatile and semivolatile ionizable compounds. In addition, in combination with capillary electrophoresis, the entire analytical process is totally organic solvent-free and is thus environmentally friendly.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Republic of Singapore 117543.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Tao
authors.initials: T
authors.lastname: Su
authors.forename: Hian Kee
authors.initials: HK
authors.lastname: Lee
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000295:instrumentation / Q000379:methods*; D019075:Electrophoresis, Capillary; D006863:Hydrogen-Ion Concentration; D010636:Phenols / Q000032:analysis / Q000302:isolation & purification*; D012972:Sodium Hydroxide / Q000737:chemistry; D013696:Temperature; D014867:Water / Q000032:analysis
chemical_list: D010636:Phenols; D014867:Water; D012972:Sodium Hydroxide