Reversal of neuromuscular effects of adenosine by specific adenosine A1-receptor antagonist in live rats.
Intravenous adenosine in-vivo was shown to potentiate the effects of non-depolarizing neuromuscular blocking agents. This study aimed to determine whether adenosine A1-receptors mediated this potentiation. The authors investigated the effects of intravenous adenosine, N6-cyclopentyladenosine, specific A1-receptor agonist, and 8-cyclopentyl-1,3-dipropylxanthine, specific A1-receptor antagonist, on neuromuscular block by vecuronium, in in-vivo rat sciatic nerve-tibialis anterior preparations. In the presence of 50% steady state block by vecuronium, adenosine, and N6-cyclopentyladenosine caused similar degree of depressions of twitch tension. Twitch tension returned to its pre-injection value more rapidly when 8-cyclopentyl-1,3-dipropylxanthine was given at the maximal block than when it was allowed to recover spontaneously. It was concluded that in in-vivo adenosine potentiated the neuromuscular effects of vecuronium through adenosine A1-receptors in rats.
Nitahara
Keiichi
K
Department of Anesthesiology, Fukuoka University School of Medicine, Fukuoka, Japan. nitahara@fukuoka-u.ac.jp
Vizi
E Sylvester
ES
Shono
Shinjiro
S
Iihoshi
Mari
M
Higuchi
Hideyuki
H
Higa
Kazuo
K
D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D058907:Adenosine A1 Receptor Agonists; D058916:Adenosine A1 Receptor Antagonists; D000818:Animals; D004347:Drug Interactions; D004357:Drug Synergism; D008297:Male; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D003473:Neuromuscular Nondepolarizing Agents / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D043682:Receptor, Adenosine A1 / Q000502:physiology; D012584:Sciatic Nerve / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects; D014673:Vecuronium Bromide / Q000494:pharmacology; D014970:Xanthines / Q000494:pharmacology*
D058907:Adenosine A1 Receptor Agonists; D058916:Adenosine A1 Receptor Antagonists; D003473:Neuromuscular Nondepolarizing Agents; D043682:Receptor, Adenosine A1; D014970:Xanthines; C048599:N(6)-cyclopentyladenosine; D014673:Vecuronium Bromide; C051360:1,3-dipropyl-8-cyclopentylxanthine; D000241:Adenosine