title: Neurovascular pathways and Alzheimer amyloid beta-peptide.
abstract: According to the prevailing amyloid cascade hypothesis, the onset and progression of a chronic neurodegenerative condition in Alzheimer disease (AD) is initiated by the amyloid beta-peptide (Abeta) accumulation in brain and consequent neuronal toxicity. Recent emphasis on co-morbidity of AD and cerebrovascular disease and the recognition that cerebrovascular dysregulation is an important feature of AD, has shed new light on neurovascular dysfunction as a possible contributor to cognitive decline and Alzheimer neurodegeneration. In the same time, this association has raised a question as to whether there is a causal relationship between cerebrovascular dysregulation and Abeta-initiated pathology, and whether influencing targets in the neurovasculature may prevent different forms of Abeta brain accumulation and/or lower pre-existing accumulates in a later stage of the disease. Pathogenic cascades which operate to dissociate normal transport exchanges between central and peripheral pools of Abeta, and decreased vascular competence leading to brain hypoperfusion and impaired Abeta clearance are discussed. We suggest that there is a link between neurovascular dysfunction and elevated brain Abeta which provides a new scenario for therapeutic interventions to control Alzheimer mental deterioration.
authors.affiliation: Frank R Smith Laboratories for Neuroscience and Neurosurgical Research, University of Rochester Medical Center, Rochester, NY 14642, USA. berislav_zlokovic@urmc.rochester.edu
authors.forename: Berislav V
authors.initials: BV
authors.lastname: Zlokovic
authors.forename: Rashid
authors.initials: R
authors.lastname: Deane
authors.forename: Jan
authors.initials: J
authors.lastname: Sallstrom
authors.forename: Nienwen
authors.initials: N
authors.lastname: Chow
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Miano
mesh_terms: D000544:Alzheimer Disease / Q000150:complications* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000098:blood supply* / Q000473:pathology*; D002561:Cerebrovascular Disorders / Q000150:complications* / Q000473:pathology; D006801:Humans; D008959:Models, Neurological
chemical_list: D016229:Amyloid beta-Peptides