Highly efficient conjugate reduction of alpha,beta-unsaturated nitriles catalyzed by copper/xanthene-type bisphosphine complexes.
Alpha,beta-unsaturated nitriles are chemoselectively reduced to the corresponding saturated nitriles in high yields using a copper-DPEphos or Xantphos complex as catalyst in the presence of polymethylhydrosiloxane (PMHS) as the stoichiometric reducing agent and t-butanol as additive.
Kim
Daesung
D
Department of Molecular Science and Technology, Ajou University, Suwon, Korea 443-749.
Park
Bu-Mahn
BM
Yun
Jaesook
J