title: Golgi positioning: are we looking at the right MAP?
abstract: One of the characteristics of the mammalian Golgi is its position adjacent to the nucleus. This characteristic is maintained through the action of the microtubule (MT) minus end-directed motor dynein and MT-associated proteins (MAPs). Recent findings suggest that GMAP-210, a member of the golgin family of proteins, may help to link Golgi membranes and vesicles with the MT cytoskeleton. However, there are good grounds to doubt that either GMAP-210 or its yeast homologue Rud3p is a MAP. Instead, they appear to function in vesicle trafficking events at the Golgi together with the GTPase ARF1 and a small membrane protein, Erv14. As such, the interesting question of how the Golgi interacts with MTs may well remain open to further investigation.
authors.affiliation: Max-Planck-Institute of Biochemistry, Martinsried, 82152 Germany. barr@biochem.mpg.de
authors.forename: Francis A
authors.initials: FA
authors.lastname: Barr
authors.forename: Johannes
authors.initials: J
authors.lastname: Egerer
mesh_terms: D020823:ADP-Ribosylation Factor 1 / Q000378:metabolism; D000818:Animals; D003598:Cytoskeletal Proteins; D006056:Golgi Apparatus / Q000378:metabolism*; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism*; D009687:Nuclear Proteins; D021381:Protein Transport / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D022161:Transport Vesicles / Q000378:metabolism*
chemical_list: D003598:Cytoskeletal Proteins; C493590:Erv14 protein, S cerevisiae; D008565:Membrane Proteins; D008869:Microtubule-Associated Proteins; D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins; C109331:TRIP11 protein, human; D020823:ADP-Ribosylation Factor 1