Regioselective one-pot synthesis of 9-alkyl-6-chloropyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazines. Reactivity of aliphatic and aromatic hydrazides.
[reaction: see text] The one-pot synthesis of new 9-alkyl-6-chloropyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazines has been achieved. Hydrazides regioselectively reacted as nucleophiles with the 3-chloro substituent of 2,3-dichloropyrido[2,3-b]pyrazine. An intramolecular cyclization afforded the tricycle nonxanthine adenosine receptor antagonists.
Unciti-Broceta
Asier
A
Departamento de Química Farmacéutica y Orgánica, Facultad de Farmacia, Campus Cartuja s/n, 18071 Granada, Spain.
Pineda-de-las-Infantas
Maria J
MJ
Díaz-Mochón
Juan J
JJ
Romagnoli
Romeo
R
Baraldi
Pier G
PG
Gallo
Miguel A
MA
Espinosa
Antonio
A