The mannose receptor mediates the cellular immune response in human coccidioidomycosis.
Mannose is the predominant monosaccharide in the coccidioidal antigen preparation T27K. Mannan and anti-CD206 antibody significantly decreased the surface expression of mannose receptor (MR) on adherent peripheral blood mononuclear cells and reduced the interleukin-2 (IL-2) release induced by T27K. These data suggest that MR mediates IL-2 release by T27K.
Ampel
Neil M
NM
Department of Medicine, University of Arizona Health Sciences Center, Tucson, Arizona, USA. nampel@email.arizona.edu
Nelson
Daniel K
DK
Li
Lijin
L
Dionne
Sara O
SO
Lake
Douglas F
DF
Simmons
Keira A
KA
Pappagianis
Demosthenes
D
D000946:Antigens, Fungal / Q000276:immunology; D003047:Coccidioidomycosis / Q000276:immunology*; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis; D037181:Lectins, C-Type / Q000502:physiology*; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology*
D000946:Antigens, Fungal; D007376:Interleukin-2; D037181:Lectins, C-Type; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D011956:Receptors, Cell Surface