title: Reductive effect of body weight in C57BL/6J mice fed a high-fat diet by Saesaengmyung Diet.
abstract: The Saesaengmyung Diet (SD) is a newly developed dietary product to help control weight. The aim of this study was to evaluate whether SD combined with a high-fat (HF) diet could influence body weight, fat accumulation, and glucose levels in blood. C57BL/6J mice were fed for 8 weeks with a standard diet, an HF diet, and an HF + 10% or HF + 20% SD diet. Body weight was recorded weekly, and plasma levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and glucose were analyzed at the end of the study. Weight increases in the 10% or 20% SD group were significantly less than in the HF diet group (p < 0.05). Plasma total cholesterol level significantly decreased by 33.5% in the 10% SD group and 38.8% in the 20% SD group, but the LDL cholesterol, HDL cholesterol, and glucose levels in the SD groups were not significantly changed. Our findings indicate that SD may be beneficial to overweight individuals in the reduction of weight gain induced by an HF diet.
authors.affiliation: College of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Hyo-Jin
authors.initials: HJ
authors.lastname: An
authors.forename: Na-Hyung
authors.initials: NH
authors.lastname: Kim
authors.forename: Yun-Kyung
authors.initials: YK
authors.lastname: Kim
authors.forename: Yeoung-Su
authors.initials: YS
authors.lastname: Lyu
authors.forename: Taekyun
authors.initials: T
authors.lastname: Shin
authors.forename: Seung-Heon
authors.initials: SH
authors.lastname: Hong
authors.forename: Hyung-Min
authors.initials: HM
authors.lastname: Kim
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D028321:Plant Preparations / Q000494:pharmacology*; D015431:Weight Loss
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D028321:Plant Preparations; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase