Circulating YKL-40 levels during human endotoxaemia.
YKL-40 is secreted by macrophages and neutrophils and patients with bacterial infections have elevated circulating YKL-40. The aim was to evaluate changes in plasma YKL-40 (determined by enzyme-linked immunosorbent assay (ELISA) at 0, 2, 4, 8, 24 and 32 h) in eight healthy volunteers after injection with Esherichia coli endotoxin or saline. Plasma YKL-40 increased after endotoxin injection from 31 microg/l (range 19-39 microg/l) to a maximum of 159 microg/l (61-552 microg/l, P < 0.01) at 24 h. The finding that plasma YKL-40 increased after endotoxin injection compared with saline (P < 0.001) suggests that YKL-40 has a functional role in infections.
Johansen
J S
JS
Department of Rheumatology Q107, University of Copenhagen, Herlev Hospital, Herlev Ringvej 75, DK-2730 Herlev, Denmark. julia.johansen@post3.tele.dk
Krabbe
K S
KS
Møller
K
K
Pedersen
B K
BK
D054392:Adipokines; D000328:Adult; D001324:Autoantigens / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D000071451:Chitinase-3-Like Protein 1; D019446:Endotoxemia / Q000276:immunology*; D004731:Endotoxins / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D004926:Escherichia coli / Q000276:immunology; D004927:Escherichia coli Infections / Q000276:immunology*; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D037102:Lectins; D007958:Leukocyte Count; D009504:Neutrophils / Q000276:immunology
D054392:Adipokines; D001324:Autoantigens; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D004731:Endotoxins; D006023:Glycoproteins; D037102:Lectins; C044101:endotoxin, Escherichia coli; D002097:C-Reactive Protein