Cytotoxic flavonoids from Platymiscium floribundum.
Two new isoflavonoids, 7-hydroxy-6,4'-dimethoxy-isoflavonequinone (1) and 2'-hydroxy-6,4',6' ',4' ''-tetramethoxy-[7-O-7' ']-bisisoflavone (2), and seven other known flavonoids, 3-hydroxy-9-methoxypterocarpan (medicarpin), 3,10-dihydroxy-9-methoxypterocarpan, 3,9-dimethoxypterocarpan (homopterocarpin) (3), 2,3,9-trimethoxypterocarpan (4), 3,4-dihydroxy-9-methoxypterocarpan (vesticarpan) (5), 2',4,4'-trihydroxychalcone (isoliquiritigenin), and 7,4'-dihydroxyflavanone (liquiritigenin) (6), were isolated from the heartwood of Platymiscium floribundum. The structures of compounds 1 and 2 were established by spectroscopic methods. Compounds 3-6 showed cytotoxic activity when evaluated against five human cancer cell lines in vitro.
Falcão
Maria José C
MJ
Curso de Pós-Graduação em Química Orgânica, Departamento de Química Orgânica e Inorgânica, Centro de Ciências, Universidade Federal do Ceará, CP 12200, Fortaleza-Ce, 60021-940, Brazil.
Pouliquem
Yvone Brígido M
YB
Lima
Mary Anne S
MA
Gramosa
Nilce Viana
NV
Costa-Lotufo
Letícia V
LV
Militão
Gardênia Carmen G
GC
Pessoa
Cláudia
C
de Moraes
Manoel Odorico
MO
Silveira
Edilberto R
ER
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001938:Brazil; D004354:Drug Screening Assays, Antitumor; D007887:Fabaceae / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
C499924:2'-hydroxy-6,4',6'',4'''-tetramethoxy(7-O-7'')-bisisoflavone; C499923:7-hydroxy-6,4'-dimethoxy-isoflavonequinone; D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D007529:Isoflavones; D011809:Quinones