Defective annexin A5 crystallization: a mechanism for pregnancy losses in the antiphospholipid syndrome.
We have accumulated a significant body of evidence that support the hypothesis that aPL antibody-mediated disruption of annexin A5 crystallization is a mechanism for RSPL in the APS. Further investigation of the functions of the annexins in placental physiology and disease are likely to be productive areas for future research.
Rand
J
J
Department of Pathology, Montefiore Medical Center and Albert Einstein Col of Medicine, Bronx, NY, USA.
Eerden
P V
PV
Wu
X X
XX
Chazotte
C
C
D000022:Abortion, Spontaneous / Q000209:etiology*; D000818:Animals; D017304:Annexin A5 / Q000737:chemistry* / Q000276:immunology; D016736:Antiphospholipid Syndrome / Q000150:complications*; D001323:Autoantibodies / Q000097:blood; D003460:Crystallization; D005260:Female; D006801:Humans; D018625:Microscopy, Atomic Force; D011247:Pregnancy; D014327:Trophoblasts / Q000737:chemistry
D017304:Annexin A5; D001323:Autoantibodies