title: [Use of cognitive evoked potentials P300 in diagnosis of affection of the higher mental functions after surgery on the heart in conditions of cardiopulmonary bypass].
abstract: Parameters of cognitive evoked potentials P300 were studied in 40 patients with ischemic heart disease subjected to coronary artery bypass graft surgery in conditions of cardiopulmonary bypass before and 7-9 days after operation. Patients underwent also neurological and neuropsychological examination. The most significant P300 parameters proved to be P3 and N2 latency, an increase of which correlated with the level of developing cognitive deficiency. A neuroprotective effect of Tracilol during the surgery was confirmed. In patients receiving this drug, cognitive deficiency and changes of P300 parameters were less pronounced. A study of cognitive evoked potentials P300 may be recommended for detecting early cognitive dysfunction and estimation of neuroprotective therapy in patients operated on in conditions of cardiopulmonary bypass.
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Buziashvili
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Aleksakhina
authors.forename: S G
authors.initials: SG
authors.lastname: Ambat'ello
authors.forename: S T
authors.initials: ST
authors.lastname: Matskeplishvili
mesh_terms: D007611:Aprotinin / Q000008:administration & dosage; D002315:Cardiopulmonary Bypass; D003071:Cognition / Q000502:physiology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control; D001026:Coronary Artery Bypass; D003627:Data Interpretation, Statistical; D018913:Event-Related Potentials, P300; D005072:Evoked Potentials, Auditory; D006490:Hemostatics / Q000008:administration & dosage; D006801:Humans; D007036:Hypothermia, Induced; D008297:Male; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000008:administration & dosage; D009483:Neuropsychological Tests; D011184:Postoperative Period; D013997:Time Factors
chemical_list: D006490:Hemostatics; D018696:Neuroprotective Agents; D007611:Aprotinin