In vitro and in vivo cytotoxicities and antileishmanial activities of thymol and hemisynthetic derivatives.
The in vitro and in vivo antileishmanial and cytotoxic activities of thymol and structural derivatives in comparison to those of Glucantime were studied. The results showed here suggest that thymol and hemisynthetic derivatives have promising antileishmanial potential and could be considered as new lead structures in the search for novel antileishmanial drugs.
Robledo
Sara
S
Programa de Estudio y Control de Enfermedades Tropicales PECET, Universidad de Antioquia, Medellín, Colombia. srobledo@guajiros.udea.edu.co
Osorio
Edison
E
Muñoz
Diana
D
Jaramillo
Luz Marina
LM
Restrepo
Adriana
A
Arango
Gabriel
G
Vélez
Iván
I
D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006224:Cricetinae; D005260:Female; D006801:Humans; D007891:Leishmania / Q000187:drug effects; D007896:Leishmaniasis / Q000188:drug therapy / Q000469:parasitology; D008297:Male; D008536:Meglumine / Q000494:pharmacology / Q000627:therapeutic use; D000077485:Meglumine Antimoniate; D009942:Organometallic Compounds / Q000494:pharmacology / Q000627:therapeutic use; D021261:Parasitic Sensitivity Tests; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D013943:Thymol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D020298:U937 Cells
D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D013729:Terpenes; D013943:Thymol; D008536:Meglumine; D000077485:Meglumine Antimoniate