title: Effect of ethanol consumption on colon cancer in an experimental model.
abstract: OBJECTIVE
  The present study was designed to examine the effect of an ethanol supplement on experimental colon carcinogenesis.
  
  
  METHODS
  One hundred and ten 10-week-old Sprague-Dawley rats were divided into five groups: group A (20 rats) received no treatment. Group B (20 rats) received a supplement of ethanol at 1.23 g/kg of body weight per day added to their drinking water for 24 weeks. Group C (30 rats) received 18 weekly doses of dimethylhydrazine (DMH) at 21 mg/kg of body weight from the beginning of the study. Group D (20 rats) received ethylen-diamin-tetracetic acid (EDTA) solution only for 18 weeks. Group E (20 rats) received ethanol at the same dose as group B plus DMH injections at the same dose as the rats in group C from the beginning of the study. All experimental animals were sacrificed after 25-27 weeks.
  
  
  RESULTS
  No significant differences in the number of rats that developed tumors, number of tumor-free animals, and number of tumors per rat, as well as in macro-microscopic tumoral findings were observed for animals in group C compared to animals in group E.
  
  
  CONCLUSIONS
  We concluded that the addition of an ethanol supplement does not modify colorectal carcinogenesis using a dynamic model of tumor induction with DMH.
authors.affiliation: Department of Surgery, Hospital Grande Covián, Arriondas, Asturias, Spain. direccionmedica.gae6@sespa.princast.es
authors.forename: S
authors.initials: S
authors.lastname: Pérez-Holanda
authors.forename: L
authors.initials: L
authors.lastname: Rodrigo
authors.forename: J
authors.initials: J
authors.lastname: Viñas-Salas
authors.forename: C
authors.initials: C
authors.lastname: Piñol-Felis
mesh_terms: D019813:1,2-Dimethylhydrazine / Q000008:administration & dosage; D000818:Animals; D002273:Carcinogens / Q000008:administration & dosage; D003110:Colonic Neoplasms / Q000139:chemically induced*; D004195:Disease Models, Animal; D000431:Ethanol / Q000008:administration & dosage; D005260:Female; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002273:Carcinogens; D000431:Ethanol; D019813:1,2-Dimethylhydrazine