Controlling diastereoselectivity in the reactions of enantiomerically pure alpha-bromoacyl-imidazolidinones with nitrogen nucleophiles: substitution reactions with retention or inversion of configuration.
Diastereoselective substitution reactions of [small alpha]-bromoacyl-imidazolidinones with nitrogen nucleophiles can be promoted with either retention or inversion of configuration by carrying out reactions under epimerising or non-epimerising conditions.
Treweeke
N R
NR
Department of Chemistry, University College London, 20 Gordon Street, London, UK.
Hitchcock
P B
PB
Pardoe
D A
DA
Caddick
S
S
D000596:Amino Acids / Q000737:chemistry; D001965:Bromides / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry*; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D013237:Stereoisomerism
D000596:Amino Acids; D001965:Bromides; D002264:Carboxylic Acids; D007093:Imidazoles; C010862:azolimine; D009584:Nitrogen