Inhibitory activity of isorhamnetin from Persicaria thunbergii on Farnesyl Protein Transferase.
The methanolic extract of the aerial parts of Persicaria thunbergii was found to show inhibitory activity on Farnesyl Protein Transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of isorhamnetin, as an inhibitor on FPTase. This compound inhibited FPTase activity in a dose-dependent manner, and the IC50 value of isorhamnetin was 37.5 microM.
Oh
Hyun Mi
HM
Korea Research Institute of Bioscience and Biotechnology, KIST, Taejeon 305-333, Korea.
Kwon
Byoung-Mog
BM
Baek
Nam-In
NI
Kim
Sung-Hoon
SH
Chung
In-Sik
IS
Park
Mi-Hyun
MH
Park
Hee Wook
HW
Lee
Jae Hyeok
JH
Park
Hye Won
HW
Kim
Eun Jeong
EJ
Kim
Dae Keun
DK
D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D002855:Chromatography, Thin Layer; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D051231:Farnesyltranstransferase; D044948:Flavonols / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000494:pharmacology; D019664:Polygonaceae / Q000737:chemistry*; D011794:Quercetin / Q000031:analogs & derivatives
D004791:Enzyme Inhibitors; D044948:Flavonols; D010936:Plant Extracts; C047368:3-methylquercetin; D011794:Quercetin; D019883:Alkyl and Aryl Transferases; D051231:Farnesyltranstransferase