Diagnosis and monitoring a case of light-chain deposition disease in the kidney using a new, sensitive immunoassay.
A 59-year-old male was diagnosed with nephrotic syndrome secondary to light-chain deposition disease. There was no other evidence of a B cell clonal disorder or amyloidosis; circulating free light chains were identified using a new immunoassay (Freelite) and used to monitor disease progression. Improvement in renal function and proteinuria following VAMP chemotherapy correlated with a reduction in circulating light-chain levels. This case demonstrates a new tool in monitoring light-chain deposition disease in the kidney.
Brockhurst
Ian
I
Department of Haematology and Oncology, Leicester Royal Infirmary, Leicester, UK. ianbrockhurst@yahoo.com
Harris
Kevin P G
KP
Chapman
Claire S
CS
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D001379:Azathioprine / Q000008:administration & dosage; D001485:Basement Membrane / Q000378:metabolism / Q000648:ultrastructure; D018450:Disease Progression; D006801:Humans; D006942:Hypergammaglobulinemia / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D007118:Immunoassay / Q000379:methods*; D007145:Immunoglobulin kappa-Chains / Q000097:blood*; D007146:Immunoglobulin lambda-Chains / Q000097:blood*; D007668:Kidney / Q000473:pathology; D007684:Kidney Tubules / Q000378:metabolism / Q000648:ultrastructure; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000209:etiology*; D011239:Prednisolone / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains; D014750:Vincristine; D011239:Prednisolone; D001379:Azathioprine; D008727:Methotrexate