[Low doses of prazosin potantiates the antinociceptive/analgesic effect of amitriptyline].
In this study, we aimed to reveal the interaction between the tricyclic antidepressant amitriptyline and a1-adrenoceptor antagonist prazosin in mice by using an analgesiometric device hot-plate. Amitriptyline (10 mg/kg) has analgesic effect as expected. Neither of the prazosin doses (0.1, 0.2, 0.5, 1 mg/kg) displayed analgesic effect alone. The combination of lower doses of prazosin (0.1, 0.2, 0.5 mg/kg) with amitriptyline (10 mg/kg) potentiated the antinociceptive effect of this drug. However, the relatively higher dose of prazosin (1 mg/kg) did not effect amitriptyline analgesia. Thus we conclude that the antinociceptive effect of amitriptyline is potentiated by low doses of prazosin.
Büyükşekerci
Murat
M
Erciyes University Medical Faculty, Department of Pharmacology, Kayseri, Turkey. muratb@erciyes.edu.tr
Gültekin
Hülya
H
D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage*; D000639:Amitriptyline / Q000008:administration & dosage*; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006358:Hot Temperature; D051379:Mice; D010146:Pain / Q000188:drug therapy*; D011224:Prazosin / Q000008:administration & dosage*
D000317:Adrenergic alpha-Antagonists; D018712:Analgesics, Non-Narcotic; D000639:Amitriptyline; D011224:Prazosin