title: Programmed cell death in the embryonic vertebrate limb.
abstract: The developing limb bud provides one of the best examples in which programmed cell death exerts major morphogenetic functions. In this work, we revise the distribution and the developmental significance of cell death in the embryonic vertebrate limb and its control by the BMP signalling pathway. In addition, paying special attention to the interdigital apoptotic zones, we review current data concerning the intracellular death machinery implicated in mesodermal limb apoptosis.
authors.affiliation: Departamento de Anatomia y Biologia Celular, Universidad de Cantabria, C/Cardenal Herrera Oria, s/n, 39011 Santander, Cantabria, Spain.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Zuzarte-Luis
authors.forename: Juan M
authors.initials: JM
authors.lastname: Hurle
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D002642:Chick Embryo; D004372:Ducks / Q000196:embryology; D004475:Ectoderm / Q000502:physiology; D005121:Extremities / Q000196:embryology* / Q000502:physiology; D008648:Mesoderm / Q000502:physiology; D051379:Mice; D015398:Signal Transduction / Q000502:physiology
chemical_list: D019485:Bone Morphogenetic Proteins