title: Effect of noradrenaline and isoproterenol on lipopolysaccharide-induced tumor necrosis factor-alpha production in whole blood from patients with chronic heart failure and the role of beta-adrenergic receptors.
abstract: Increased levels of tumor necrosis factor-alpha (TNF-alpha) correlate with poor prognoses in chronic heart failure (CHF). This study demonstrated that noradrenaline and isoproterenol inhibit TNF-alpha production in patients with CHF in ex vivo whole blood in a dose-dependent fashion. The beta-blocker bisoprolol abolishes this effect.
authors.affiliation: Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom. stephan.von.haehling@web.de
authors.forename: Stephan
authors.initials: S
authors.lastname: von Haehling
authors.forename: Sabine
authors.initials: S
authors.lastname: Genth-Zotz
authors.forename: Aidan P
authors.initials: AP
authors.lastname: Bolger
authors.forename: Paul R
authors.initials: PR
authors.lastname: Kalra
authors.forename: Michael
authors.initials: M
authors.lastname: Kemp
authors.forename: Ian M
authors.initials: IM
authors.lastname: Adcock
authors.forename: Philip A
authors.initials: PA
authors.lastname: Poole-Wilson
authors.forename: Rainer
authors.initials: R
authors.lastname: Dietz
authors.forename: Stefan D
authors.initials: SD
authors.lastname: Anker
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000328:Adult; D017298:Bisoprolol / Q000494:pharmacology; D002317:Cardiovascular Agents / Q000494:pharmacology*; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000096:biosynthesis / Q000187:drug effects*
chemical_list: D000319:Adrenergic beta-Antagonists; D002317:Cardiovascular Agents; D008070:Lipopolysaccharides; D011943:Receptors, Adrenergic, beta; D014409:Tumor Necrosis Factor-alpha; D007545:Isoproterenol; D009638:Norepinephrine; D017298:Bisoprolol