title: Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances.
abstract: Ten healthy adults participated in a randomized, crossover drug interaction study testing procainamide only, procainamide plus levofloxacin, and procainamide plus ciprofloxacin. During levofloxacin therapy, most procainamide and N-acetylprocainamide (NAPA) pharmacokinetic parameters, including decreased renal clearances and renal clearance/creatinine clearance ratios, changed (P < 0.05). During ciprofloxacin treatment, only procainamide and NAPA renal clearances decreased significantly.
authors.affiliation: Department of Pharmacy, Box 357630, University of Washington, Seattle, WA 98195. labauer@u.washington.edu.
authors.forename: Larry A
authors.initials: LA
authors.lastname: Bauer
authors.forename: Douglas J
authors.initials: DJ
authors.lastname: Black
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Lill
authors.forename: Julie
authors.initials: J
authors.lastname: Garrison
authors.forename: Vidmantas A
authors.initials: VA
authors.lastname: Raisys
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Hooton
mesh_terms: D000120:Acecainide / Q000493:pharmacokinetics*; D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000493:pharmacokinetics*; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D002939:Ciprofloxacin / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D064704:Levofloxacin; D008297:Male; D015242:Ofloxacin / Q000493:pharmacokinetics*; D011342:Procainamide / Q000493:pharmacokinetics*
chemical_list: D000889:Anti-Arrhythmia Agents; D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin; D064704:Levofloxacin; D000120:Acecainide; D015242:Ofloxacin; D011342:Procainamide