Spatial resolution of fMRI in the human parasylvian cortex: comparison of somatosensory and auditory activation.
In spite of its outstanding spatial resolution, the biological resolution of functional MRI may be worse because it depends on the vascular architecture of the brain. Here, we compared the activation patterns of the secondary somatosensory and parietal ventral cortex (SII/PV) with that of the primary auditory cortex and adjacent areas (AI/AII). These two brain regions are located immediately adjacent to each other on opposite banks of the Sylvian fissure, and are anatomically and functionally distinct. In 12 healthy subjects, SII/PV was activated by pneumatic tactile stimuli applied to the index finger (0.5 cm2 contact area, 4 bar pressure), and AI/AII by amplitude-modulated tones (800 Hz carrier frequency, modulated at 24-36 Hz). Functional images were obtained with a 1.5-T scanner and were evaluated using SPM99. Sensitivity of fMRI activation in this unselected sample was 71% for tactile and 83% for auditory stimulation. Group analysis showed activation of SII/PV by tactile and activation of three locations in AI/AII by auditory stimuli. Distributions extended to the opposite side of the fissure (19-58% after tactile and 13-14% after auditory stimulation, depending on the side of stimulation/hemisphere). Morphometry of individual sulcal anatomy revealed that the course of the Sylvian fissure varied by 5.3 mm (SD) in vertical direction. Taking this into account, SII/PV was located 5.8 +/- 2.7 mm above the Sylvian fissure, whereas AI/AII was located 6.3 +/- 1.7 mm below the Sylvian fissure. Even in individual analysis, the most significant voxel after tactile stimuli in one subject was found on the "wrong" side of the fissure; this error could be ascribed to the spatial normalization procedure. These data show that fMRI signals may overlap substantially, even if the activated regions are separated by 12 mm across a major sulcus. Spatial normalization to an atlas template can introduce additional variance. Individual sulcal anatomy should be preferred over mean atlas locations.
Ozcan
Mustafa
M
Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Saarstr. 21, D-55099 Mainz, Germany.
Baumgärtner
Ulf
U
Vucurevic
Goran
G
Stoeter
Peter
P
Treede
Rolf-Detlef
RD
D000161:Acoustic Stimulation; D000328:Adult; D000704:Analysis of Variance; D001303:Auditory Cortex / Q000033:anatomy & histology / Q000502:physiology*; D001931:Brain Mapping; D002535:Cerebral Aqueduct / Q000033:anatomy & histology / Q000502:physiology*; D004292:Dominance, Cerebral / Q000502:physiology; D005072:Evoked Potentials, Auditory / Q000502:physiology; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D005260:Female; D005385:Fingers / Q000294:innervation; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D010296:Parietal Lobe / Q000033:anatomy & histology / Q000502:physiology*; D012016:Reference Values; D012680:Sensitivity and Specificity; D013003:Somatosensory Cortex / Q000033:anatomy & histology / Q000502:physiology*; D014110:Touch / Q000502:physiology*