title: Nutritional inadequacy in adults with muscular dystrophy.
abstract: Patients with muscular dystrophy may be prone to nutrient deficiency due to mobility limitations or oropharyngeal weakness. Patients with myotonic muscular dystrophy (DM1) may be particularly prone to nutritional deficiencies from associated dysmotility of the entire gastrointestinal tract. We prospectively evaluated nutritional intake, body composition, and muscle strength in adult patients with DM1 (n = 29) and other muscular dystrophies (n = 22) on two occasions separated by approximately 6 months. Handgrip was significantly lower and knee extension higher for DM1 compared to other dystrophies, with no between-group differences in nutritional intakes. Many patients in both groups demonstrated inadequate nutrient intake of protein, energy, vitamins (water and fat soluble), and minerals (calcium and magnesium). Significant correlations were found between measures of strength and certain individual nutrients (e.g., copper and water-soluble vitamins). These data indicate that a substantial number of adults with muscular dystrophy do not meet current dietary intake recommendations. The potential clinical implications of these findings are discussed.
authors.affiliation: Department of Medicine, Room 4U4, McMaster University, 1200 Main Street W., Hamilton, Ontario, L8N 3Z5, Canada.
authors.forename: Bahareh
authors.initials: B
authors.lastname: Motlagh
authors.forename: Jay R
authors.initials: JR
authors.lastname: MacDonald
authors.forename: Mark A
authors.initials: MA
authors.lastname: Tarnopolsky
mesh_terms: D000328:Adult; D001361:Avitaminosis / Q000175:diagnosis / Q000503:physiopathology; D001823:Body Composition / Q000502:physiology; D004040:Dietary Carbohydrates / Q000378:metabolism; D004044:Dietary Proteins / Q000378:metabolism; D002149:Energy Intake / Q000502:physiology*; D017079:Exercise Tolerance / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D044342:Malnutrition / Q000175:diagnosis* / Q000209:etiology* / Q000503:physiopathology; D008903:Minerals / Q000378:metabolism; D009119:Muscle Contraction / Q000502:physiology; D018908:Muscle Weakness / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D009223:Myotonic Dystrophy / Q000150:complications* / Q000503:physiopathology; D018673:Nutrition Policy; D011446:Prospective Studies
chemical_list: D004040:Dietary Carbohydrates; D004044:Dietary Proteins; D008903:Minerals