Risk factors of cytomegalovirus infection after living donor liver transplantation.
OBJECTIVE
Cytomegalovirus (CMV) infection is one of the most common infectious diseases complicating liver transplantation. Data regarding the incidence and results after CMV infection or disease after living donor liver transplantation, however, are limited.


METHODS
A total of 169 patients who underwent living donor liver transplantation in. our department were enrolled in the study. All of the patients were preemptively treated with intravenous ganciclovir (10mg/kg/d) when the pp65 antigenemia assay was positive. The incidence of CMV infection and disease, and risk factors for CMV infection were evaluated.


RESULTS
The incidence of CMV infection and CMV disease was 44% and 3%, respectively. Acute rejection was significantly associated with CMV infection.


CONCLUSIONS
The incidence of CMV disease was low, suggesting that our strategy might be effective for preventing the development of CMV disease.
Akamatsu
Nobuhisa
N
Artificial Organ and Transplantation Surgery Division, Department of Surgery University of Tokyo, Tokyo, Japan.
Sugawara
Yasuhiko
Y
Kaneko
Junichi
J
Kishi
Yoji
Y
Makuuchi
Masatoshi
M
D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D004334:Drug Administration Schedule; D005260:Female; D015774:Ganciclovir / Q000008:administration & dosage; D006801:Humans; D008107:Liver Diseases / Q000601:surgery*; D016031:Liver Transplantation / Q000009:adverse effects*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors
D000998:Antiviral Agents; D015774:Ganciclovir