Anti-Jo-1 antibodies.
Anti-Jo-1 antibody is a myositis specific autoantibody most commonly found in patients with idiopathic inflammatory myopathies (IIM). This antibody is directed against the histidyl-tRNA synthetase which catalyses the binding of the histidine to its cognate tRNA during protein synthesis. It can be considered a specific marker of IIM, predominantly found in 20-30% of patients with PM and in the 60-70% of those with interstitial pulmonary fibrosis. These antibodies are also found in DM, although less frequently than in PM, and are rare in children with PM or DM and in other connective tissue diseases.ELISA, CIE and immunoblotting are highly specific and sensitive techniques for testing anti-Jo-1 antibodies. The detection of this antibody is particularly useful in diagnosis and classification of IIM. Moreover, anti-Jo-1 serum levels strongly correlate with disease activity representing a good marker for disease monitoring.
Zampieri
Sandra
S
Department of Medical and Surgical Science Division of Rheumatology, University of Padova, Italy.
Ghirardello
Anna
A
Iaccarino
Luca
L
Tarricone
Elena
E
Gambari
Pier Franca
PF
Doria
Andrea
A
D000974:Antibodies, Antinuclear / Q000097:blood* / Q000235:genetics / Q000266:history; D003240:Connective Tissue Diseases / Q000175:diagnosis / Q000276:immunology; D003937:Diagnosis, Differential; D019084:Fluorescent Antibody Technique, Indirect; D049673:History, 20th Century; D006801:Humans; D007118:Immunoassay / Q000379:methods / Q000706:statistics & numerical data; D007125:Immunogenetics; D007132:Immunoglobulin Isotypes / Q000097:blood; D009220:Myositis / Q000175:diagnosis / Q000235:genetics / Q000266:history / Q000276:immunology; D017285:Polymyositis / Q000175:diagnosis / Q000276:immunology; D012680:Sensitivity and Specificity
D000974:Antibodies, Antinuclear; D007132:Immunoglobulin Isotypes; C046750:Jo-1 antibody