[Study of Parkinson's disease-causing mechanism and development of anti-Parkinson's disease drugs using endogenous substances in brain].
There have been many reports showing 1,2,3,4-tetrahydroisoquinoline(TIQ) derivatives may be related to the onset of Parkinson's disease. 1-Benzyl-1,2,3,4-tetrahydroisoquinoline(1BnTIQ) was detected as a novel endogenous amine in mouse brain and parkinsonian CSF. The level of 1BnTIQ was very high in CSF of some parkinsonian patients compared with that of controls with other neurological diseases. Repeated administration of 1BnTIQ induced behavior abnormalities. We suggest that 1BnTIQ may be related to the idiopathic Parkinson's disease. On the other hand, 1-methyl TIQ (1MeTIQ), an endogenous amine in the brain, prevented 1BnTIQ-induced parkinsonism in mice. So 1MeTIQ is a candidate for anti-parkinsonian drugs.
Ohta
Shigeru
S
Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1-2- 3, Minami-ku, Hiroshima, 734-8551, Japan. sohta@hiroshima-u.ac.jp
D000818:Animals; D001923:Brain Chemistry; D006801:Humans; D010300:Parkinson Disease / Q000188:drug therapy / Q000209:etiology*; D044005:Tetrahydroisoquinolines / Q000032:analysis* / Q000134:cerebrospinal fluid
D044005:Tetrahydroisoquinolines