[Study on the effect of cyclic adenosine monophosphate on human erythrocyte membrane by FTIR and computer aided analysis].
The effect of cAMP on erythrocyte membrane proteins was studied by FITR, deconvolution and curvefitting. It was found that the change of cAMP's concentration affects the secondary structure of membrane proteins. The regulation of cAMP has a best concentration region, during which cAMP has the strongest effect.
Li
Y
Y
Bioorganic Phosphorus Chemistry Laboratory, Department of Chemistry, Tsinghua University, 100084 Beijing.
Wei
M
M
Zhao
Y
Y
Yu
J
J
Zhou
Q
Q
Hu
X
X
D003198:Computer Simulation; D000242:Cyclic AMP / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry; D008958:Models, Molecular; D017433:Protein Structure, Secondary / Q000187:drug effects; D017550:Spectroscopy, Fourier Transform Infrared
D008565:Membrane Proteins; D000242:Cyclic AMP