title: A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementia.
abstract: OBJECTIVE
  To evaluate single-voxel proton magnetic resonance spectroscopy (SV-MRS) and magnetic resonance spectroscopic imaging (MRSI) metabolite results in individuals with HIV dementia.
  
  
  METHODS
  Twenty HIV-positive (HIV+) individuals underwent SV-MRS (TE 35 msec) and MRSI (TE 280 msec). Results were stratified according to serostatus, dementia severity, psychomotor speed performance, and functional impairment.
  
  
  RESULTS
  HIV+ individuals with psychomotor slowing had an increased myoinositol/creatine (mI/Cr) ratio (0.63 vs. 0.45) in the frontal white matter using SV-MRS and an increased choline (Cho)/Cr ratio (1.88 vs. 1.41) in the mesial frontal gray matter using MRSI compared to HIV+ individuals without psychomotor slowing. Using MRSI, subjects with HIV dementia also had a decreased N-acetyl aspartate (NAA)/Cho ratio (1.55 vs. 2.53) compared to HIV+ individuals without cognitive impairment in the mesial frontal gray matter. Both techniques detected metabolite ratio abnormalities associated with abnormal functional performance.
  
  
  CONCLUSIONS
  SV-MRS and MRSI offer complementary roles in evaluating individuals with HIV dementia. Short TE SV-MRS measures mI, which may be elevated in early HIV dementia, whereas MRSI provides wider spatial coverage to examine specific regional changes.
authors.affiliation: Department of Neurology, Johns Hopkins Bayview Medical Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA. sacktor@jhmi.edu
authors.forename: Ned
authors.initials: N
authors.lastname: Sacktor
authors.forename: Richard L
authors.initials: RL
authors.lastname: Skolasky
authors.forename: Thomas
authors.initials: T
authors.lastname: Ernst
authors.forename: Xiangling
authors.initials: X
authors.lastname: Mao
authors.forename: Ola
authors.initials: O
authors.lastname: Selnes
authors.forename: Martin G
authors.initials: MG
authors.lastname: Pomper
authors.forename: Linda
authors.initials: L
authors.lastname: Chang
authors.forename: Kai
authors.initials: K
authors.lastname: Zhong
authors.forename: Dikoma C
authors.initials: DC
authors.lastname: Shungu
authors.forename: Karen
authors.initials: K
authors.lastname: Marder
authors.forename: Dean
authors.initials: D
authors.lastname: Shibata
authors.forename: Giovanni
authors.initials: G
authors.lastname: Schifitto
authors.forename: Linda
authors.initials: L
authors.lastname: Bobo
authors.forename: Peter B
authors.initials: PB
authors.lastname: Barker
mesh_terms: D015526:AIDS Dementia Complex / Q000175:diagnosis*; D000328:Adult; D001923:Brain Chemistry; D003404:Creatinine / Q000032:analysis; D005260:Female; D006801:Humans; D007294:Inositol / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male
chemical_list: D007294:Inositol; D003404:Creatinine