title: Successful lysis of intra-cardiac thrombi with streptokinase in patients with renal failure; two case reports and review of the literature.
abstract: In situ formation of thrombi within the cardiac cavities carries a substantial risk of morbidity and mortality due to the inherent danger of embolization to vital organs. This typically occurs in patients with underlying cardiac disorders associated with low flow state favoring regional stagnation of blood and subsequent clotting. Occasionally, extra-cardiac conditions such as renal failure predispose to the development of intra-cardiac thrombi in the presence or absence of identifiable cardiac abnormalities. Once identified, the appropriate treatment of such thrombi remains highly controversial. Here, we report on the successful and safe use of streptokinase in two patients with end stage renal disease with high risk left ventricular, right ventricular and right atrial thrombi.
authors.affiliation: Department of Cardiovascular Diseases, King Faisal Specialist Hospital and Research Center Riyadh, Saudi Arabia. hassanw@kfshrc.edu.sa
authors.forename: Walid
authors.initials: W
authors.lastname: Hassan
authors.forename: Fayez
authors.initials: F
authors.lastname: ElShaer
authors.forename: Mohamed E I D
authors.initials: ME
authors.lastname: Fawzy
authors.forename: Nathem
authors.initials: N
authors.lastname: Akhras
authors.forename: Rashid
authors.initials: R
authors.lastname: Abdullah
authors.forename: Bahaa M
authors.initials: BM
authors.lastname: Fadel
mesh_terms: D000328:Adult; D003328:Coronary Thrombosis / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D019560:Echocardiography, Three-Dimensional / Q000379:methods; D005260:Female; D006801:Humans; D011859:Radiography; D051437:Renal Insufficiency / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D013300:Streptokinase / Q000627:therapeutic use*
chemical_list: D013300:Streptokinase