title: Effect of antibiotics on growth and laccase production from Cyathus bulleri and Pycnoporus cinnabarinus.
abstract: The effect of nine different antibiotics (chloramphenicol, ampicillin trihydrate, kanamycin A monosulfate, neomycin sulfate, erythromycin, thiostrepton, tetracycline, apramycin sulfate and streptomycin sulfate) on growth and laccase production from Cyathus bulleri and Pycnoporus cinnabarinus has been investigated. All the antibiotics tested at a concentration of 200 mg/l affected the fungal growth, release of protein and laccase production to different extent. Inhibition in fungal growth was found to be positively correlated with increase in laccase production. Interestingly, apramycin sulfate inhibited biomass production (14.9-26.2%), nevertheless, it stimulated maximum laccase production (18.2 U/ml) in both the fungi. Increasing concentrations of apramycin sulfate enhanced laccase production from P. cinnabarinus but not from C. bulleri.
authors.affiliation: Department of Microbiology, University of Delhi South Campus, Benito Juarez Road, New Delhi 110021, India.
authors.forename: Shikha
authors.initials: S
authors.lastname: Dhawan
authors.forename: Rup
authors.initials: R
authors.lastname: Lal
authors.forename: Manjit
authors.initials: M
authors.lastname: Hanspal
authors.forename: Ramesh Chander
authors.initials: RC
authors.lastname: Kuhad
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001487:Basidiomycota / Q000187:drug effects* / Q000201:enzymology* / Q000254:growth & development; D042845:Laccase / Q000096:biosynthesis*; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D042845:Laccase