Positive correlation between sialyl Lewis X expression and pathologic findings in renal cell carcinoma.
BACKGROUND
Interaction between tumor cells and endothelium plays a major role in cancer invasion and metastasis. Among various cell adhesion molecules, the cognate interaction between sialyl Lewis antigen expressed in the tumor cell surface and E-selectin expressed on endothelial cells is considered to be crucial for the tumor cell adhesion to the endothelium.


METHODS
The sialyl Lewis X (sL(X)) expression in 45 specimens from renal cell carcinoma patients was examined using immunohistochemistry.


RESULTS
In this study, we demonstrate that the immunoreactivity for sL(X) in renal cell carcinoma specimens not only correlates with conventional histopathologic parameters but also serves as a useful indicator for the prognosis of renal cell carcinoma.


CONCLUSIONS
Since beneficial effect of cimetidine has been reported and ascribed to its inhibitory action on the expression of E-selectin, a ligand molecule of sialyl Lewis antigen, cimetidine may also show inhibitory effect on the tumor recurrence and metastasis of renal cell carcinoma with high level of sL(X) expression.
Tozawa
Keiichi
K
Department of Nephro-urology, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan.
Okamoto
Takashi
T
Kawai
Noriyasu
N
Hashimoto
Yoshihiro
Y
Hayashi
Yutaro
Y
Kohri
Kenjiro
K
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D002292:Carcinoma, Renal Cell / Q000473:pathology*; D002927:Cimetidine / Q000627:therapeutic use; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000473:pathology*; D007983:Lewis Blood Group Antigens; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009844:Oligosaccharides / Q000032:analysis*; D000080506:Sialyl Lewis X Antigen
D000276:Adjuvants, Immunologic; D007983:Lewis Blood Group Antigens; D009844:Oligosaccharides; D000080506:Sialyl Lewis X Antigen; D002927:Cimetidine