title: Structural and mechanistic diversity of secondary transporters.
abstract: Recent reports on the three-dimensional structure of secondary transporters have dramatically increased our knowledge of the translocation mechanism of ions and solutes. The structures of five transporters at atomic resolution have yielded four different folds and as many different translocation mechanisms. The structure of the glutamate transporter homologue GltPh confirmed the role of pore-loop structures as essential parts of the translocation mechanism in one family of secondary transporters. Biochemical evidence for pore-loop structures in several other families suggest that they might be common in secondary transporters, adding to the structural and mechanistic diversity of secondary transporters.
authors.affiliation: Department of Microbiology, Groningen Biomolecular and Biotechnology Institute, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands.
authors.forename: Iwona
authors.initials: I
authors.lastname: Sobczak
authors.forename: Juke S
authors.initials: JS
authors.lastname: Lolkema
mesh_terms: D027322:Amino Acid Transport System X-AG / Q000737:chemistry / Q000502:physiology; D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins / Q000737:chemistry* / Q000502:physiology*; D001692:Biological Transport; D002352:Carrier Proteins / Q000737:chemistry / Q000502:physiology; D027682:Cation Transport Proteins / Q000737:chemistry / Q000502:physiology; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000502:physiology; D008565:Membrane Proteins / Q000737:chemistry / Q000502:physiology; D026901:Membrane Transport Proteins / Q000737:chemistry / Q000502:physiology; D009004:Monosaccharide Transport Proteins / Q000737:chemistry / Q000502:physiology; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D027981:Symporters / Q000737:chemistry* / Q000502:physiology*
chemical_list: D027322:Amino Acid Transport System X-AG; D001426:Bacterial Proteins; D002352:Carrier Proteins; D027682:Cation Transport Proteins; D029968:Escherichia coli Proteins; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D009004:Monosaccharide Transport Proteins; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D027981:Symporters; C083496:AcrB protein, E coli; C111096:AmtB protein, E coli; C488962:GlpT protein, E coli; C050221:LacY protein, E coli