title: [Long-term bisphosphonate administration and its effect on bone metabolism].
abstract: Since bisphosphonates (BPs) suppress bone turnover, potential concerns regarding bone metabolism during long term BP administration have been raised. Now up to 10 years follow-up of clinical trials with data of bone metabolism are available. There was no adverse effect on bone metabolism with long term BP treatment, and increase in bone mineral density and reduction in fracture risk were retained.
authors.affiliation: Rehabilitation Division, Tottori University Hospital Faculty of Medicine, Tottori University, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hagino
mesh_terms: D000818:Animals; D015415:Biomarkers; D015519:Bone Density; D001862:Bone Resorption / Q000175:diagnosis / Q000378:metabolism* / Q000517:prevention & control; D001842:Bone and Bones / Q000378:metabolism*; D002986:Clinical Trials as Topic; D003094:Collagen; D024042:Collagen Type I; D004164:Diphosphonates / Q000008:administration & dosage* / Q000009:adverse effects*; D050723:Fractures, Bone / Q000517:prevention & control; D006801:Humans; D010024:Osteoporosis / Q000175:diagnosis / Q000378:metabolism* / Q000517:prevention & control; D010455:Peptides; D012306:Risk; D016103:Spinal Fractures / Q000209:etiology / Q000517:prevention & control; D013997:Time Factors; D014944:World Health Organization
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D004164:Diphosphonates; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D003094:Collagen