Microtubule tips redirect actin assembly.
In fission yeast, a protein complex that rides on the plus end of growing microtubules regulates establishment of new sites of actin cable assembly, necessary for cell growth, from one to both ends of the rod-shaped cells. Martin et al. describe a direct molecular link between the microtubule tip complex and the formin for3p, the nucleator for assembly of actin cables, which is necessary for this regulatory switch.
Bretscher
Anthony
A
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
D000199:Actins / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism; D000080865:Formins; D008870:Microtubules / Q000378:metabolism* / Q000648:ultrastructure; D012568:Schizosaccharomyces / Q000166:cytology / Q000378:metabolism; D029702:Schizosaccharomyces pombe Proteins / Q000378:metabolism
D000199:Actins; D018797:Cell Cycle Proteins; C444419:FOR3 protein, S pombe; D000080865:Formins; D029702:Schizosaccharomyces pombe Proteins