title: Three-dimensional virtual microscopy of colorectal biopsies.
abstract: Conventional optical microscopy of specimens from colorectal biopsies commonly produces diagnostic errors due to incomplete sampling or poor orientation. Obtaining additional sections or re-embedding may help avoid these errors, but can prolong turnaround time. We describe new technology, which incorporates exhaustive sectioning, 3-dimensional reconstruction, and virtual microscopy, that may eliminate these problems by enabling pathologists to rapidly examine entire specimens and convert poorly oriented mucosa to well-oriented mucosa.
authors.affiliation: Department of Pathology, University of California, Irvine School of Medicine, Irvine, USA. mlwu@uci.edu
authors.forename: Mark Li-cheng
authors.initials: ML
authors.lastname: Wu
authors.forename: Viktor Sebestyen
authors.initials: VS
authors.lastname: Varga
authors.forename: Viktor
authors.initials: V
authors.lastname: Kamaras
authors.forename: Levente
authors.initials: L
authors.lastname: Ficsor
authors.forename: Attila
authors.initials: A
authors.lastname: Tagscherer
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Tulassay
authors.forename: Bela
authors.initials: B
authors.lastname: Molnar
mesh_terms: D000368:Aged; D001706:Biopsy; D003111:Colonic Polyps / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000473:pathology*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008853:Microscopy / Q000379:methods*