Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances.
Ten healthy adults participated in a randomized, crossover drug interaction study testing procainamide only, procainamide plus levofloxacin, and procainamide plus ciprofloxacin. During levofloxacin therapy, most procainamide and N-acetylprocainamide (NAPA) pharmacokinetic parameters, including decreased renal clearances and renal clearance/creatinine clearance ratios, changed (P < 0.05). During ciprofloxacin treatment, only procainamide and NAPA renal clearances decreased significantly.
Bauer
Larry A
LA
Department of Pharmacy, Box 357630, University of Washington, Seattle, WA 98195. labauer@u.washington.edu.
Black
Douglas J
DJ
Lill
Jennifer S
JS
Garrison
Julie
J
Raisys
Vidmantas A
VA
Hooton
Thomas M
TM
D000120:Acecainide / Q000493:pharmacokinetics*; D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000493:pharmacokinetics*; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D002939:Ciprofloxacin / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D064704:Levofloxacin; D008297:Male; D015242:Ofloxacin / Q000493:pharmacokinetics*; D011342:Procainamide / Q000493:pharmacokinetics*
D000889:Anti-Arrhythmia Agents; D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin; D064704:Levofloxacin; D000120:Acecainide; D015242:Ofloxacin; D011342:Procainamide