title: Fibrin adhesive implant in wound healing repair of dental sockets with topical application of epsilon aminocaproic acid: histological analysis.
abstract: The aim of the study was to evaluate wound healing repair of dental sockets after topical application of 5% epsilon-aminocaproic acid (EACA) and the use of fibrin adhesive implant in rats under anticoagulant therapy with warfarin. Sixty Albinus wistar rats were used, divided into three groups of 20. In Group I, the animals were given 0.1 mL/100 mg of 0.9% saline solution per day, beginning 6 days before dental extraction and continuing throughout the experimental period. In Group II, the animals received 0.03 mL of sodium warfarin daily, beginning 6 days before the surgery and continuing until the day of sacrifice; after tooth extractions, the sockets were filled with fibrin adhesive material. In Group III the animals were treated as in Group II, and after extractions, the sockets were irrigated with 5 mL of 5% EACA and filled with the same fibrin adhesive material. All groups presented biological phases of wound healing repair, the differences being evident only in the chronology. The results obtained in Group III were very similar to those of Group I in the last period of wound repair, whereas Group II presented a late chronology compared to the other groups.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Universidade do Sagrado Coração (USC), Bauru, Sao Pãulo, Brazil.
authors.forename: Luis Eduardo M
authors.initials: LE
authors.lastname: Padovan
authors.forename: Tetuo
authors.initials: T
authors.lastname: Okamoto
authors.forename: Maria Cristina Rossifini Alves
authors.initials: MC
authors.lastname: Rezende
authors.forename: Victor Prado
authors.initials: VP
authors.lastname: Curvêllo
authors.forename: Daniela
authors.initials: D
authors.lastname: Nicolielo
authors.forename: Mariza Akemi
authors.initials: MA
authors.lastname: Matsumoto
mesh_terms: D000287:Administration, Topical; D015119:Aminocaproic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use; D015718:Fibrin Tissue Adhesive; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D023421:Models, Animal; D019736:Prostheses and Implants; D011516:Prothrombin / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D014859:Warfarin / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology*
chemical_list: D000925:Anticoagulants; D015718:Fibrin Tissue Adhesive; D005343:Fibrinolytic Agents; D014859:Warfarin; D011516:Prothrombin; D015119:Aminocaproic Acid