title: Mutations in the tyrosine kinase domain of the epidermal growth factor receptor in non-small cell lung cancer.
abstract: We evaluated somatic genetic alterations in the kinase domain of the EGFR gene in the tumors of 219 non-small cell lung cancer patients of primarily Caucasian and African American origins. We identified 26 patients (12%) whose tumors had a mutation in the EGFR gene, and 11 (5%) patients carried novel genomic variations consistent with germ-line polymorphisms. All but one mutation were identified in Caucasian patients affected with adenocarcinoma. EGFR mutations were more frequent in women and in nonsmokers, but a significant portion of the affected patients were men (12 of 26) and current or past smokers accounted for half of the patients affected (13 of 26). Screening subjects with EGFR mutations may identify patients whose tumors could respond to targeted therapy using tyrosine kinase inhibitors.
authors.affiliation: Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute/NIH, 41 Library Drive, Bethesda, MD 20892, USA.
authors.forename: Sei Hoon
authors.initials: SH
authors.lastname: Yang
authors.forename: Leah E
authors.initials: LE
authors.lastname: Mechanic
authors.forename: Ping
authors.initials: P
authors.lastname: Yang
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Landi
authors.forename: Elise D
authors.initials: ED
authors.lastname: Bowman
authors.forename: Jason
authors.initials: J
authors.lastname: Wampfler
authors.forename: Daoud
authors.initials: D
authors.lastname: Meerzaman
authors.forename: Kyeong Man
authors.initials: KM
authors.lastname: Hong
authors.forename: Felicia
authors.initials: F
authors.lastname: Mann
authors.forename: Tatiana
authors.initials: T
authors.lastname: Dracheva
authors.forename: Junya
authors.initials: J
authors.lastname: Fukuoka
authors.forename: William
authors.initials: W
authors.lastname: Travis
authors.forename: Neil E
authors.initials: NE
authors.lastname: Caporaso
authors.forename: Curtis C
authors.initials: CC
authors.lastname: Harris
authors.forename: Jin
authors.initials: J
authors.lastname: Jen
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics*; D000328:Adult; D001741:Black or African American; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D017434:Protein Structure, Tertiary; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D012907:Smoking; D044465:White People
chemical_list: D066246:ErbB Receptors; D011505:Protein-Tyrosine Kinases