title: Catechins attenuate myocardial cell infiltration and fibrosis but do not prolong graft survival in murine cardiac allografts.
abstract: Although tea catechins have many biological functions, their effects on cardiac allograft rejection have not been well studied. We used a total allomismatch heart transplant model to test the effects of catechins in cardiac rejection. We have shown that cell infiltration and fibrosis were suppressed in catechin-treated allografts compared with nontreated transplants. However, catechins did not statistically prolong graft survival. We conclude that catechins have a potential to suppress inflammation in cardiac allografts.
authors.affiliation: Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan. jsuzuki.cvm@tmd.ac.jp
authors.forename: J
authors.initials: J
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Ogawa
authors.forename: Y M
authors.initials: YM
authors.lastname: Sagesaka
authors.forename: M
authors.initials: M
authors.lastname: Isobe
mesh_terms: D000818:Animals; D002392:Catechin / Q000494:pharmacology*; D005355:Fibrosis; D006085:Graft Survival / Q000187:drug effects*; D016027:Heart Transplantation / Q000473:pathology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009206:Myocardium / Q000473:pathology; D013662:Tea; D014184:Transplantation, Homologous / Q000276:immunology
chemical_list: D013662:Tea; D002392:Catechin