title: Adenosine receptor ligands and dizocilpine-induced antinociception in mice.
abstract: Interactions between adenosine receptor ligands and dizocilpine (uncompetitive NMDA receptor antagonist) was studied in antinociceptive, writhing test in mice. Minimal effective, antinociceptive doses of adenosine receptor agonists were: 0.1 mg/kg (NECA--A1/A2 agonist). Generally, these agonists did not potentiate the subthreshold dose of dizocilpine (0.05 mg/kg). Of all adenosine receptor antagonists used, only caffeine (A2 and A2 antagonists) reversed dizocilpine-induced (0.1 mg/kg) antinociception dose-dependently. These findings indicate that dizocilpin-induced antinociception in the writhing test is only partly influenced by adenosine receptor ligands.
authors.affiliation: Department of Pharmacodynamics, Skubiszewski Medical University of Lublin, Lublin, Poland. el234@panaceum.am.lublin.pl
authors.forename: Danuta
authors.initials: D
authors.lastname: Malec
authors.forename: Ewa
authors.initials: E
authors.lastname: Poleszak
mesh_terms: D019342:Acetic Acid; D000818:Animals; D001522:Behavior, Animal; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009619:Nociceptors / Q000187:drug effects* / Q000378:metabolism; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D058906:Purinergic P1 Receptor Agonists; D018047:Receptors, Purinergic P1 / Q000378:metabolism*; D013805:Theobromine / Q000031:analogs & derivatives* / Q000494:pharmacology; D014970:Xanthines / Q000494:pharmacology
chemical_list: D018691:Excitatory Amino Acid Antagonists; D058906:Purinergic P1 Receptor Agonists; D018047:Receptors, Purinergic P1; D014970:Xanthines; C057837:3,7-dimethyl-1-propargylxanthine; D016291:Dizocilpine Maleate; C051360:1,3-dipropyl-8-cyclopentylxanthine; D013805:Theobromine; D019342:Acetic Acid