title: Brief communication: duration of platelet dysfunction after a 7-day course of Ibuprofen.
abstract: BACKGROUND
  Despite a paucity of evidence, clinicians routinely advise that patients discontinue using nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, at least 1 week before most surgical procedures.
  
  
  OBJECTIVE
  To define the duration of ibuprofen-induced platelet dysfunction.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Denver/Aurora, Colorado.
  
  
  METHODS
  11 healthy adult volunteers.
  
  
  METHODS
  Individuals were tested at baseline and serially after completion of a 7-day course of ibuprofen (600 mg orally every 8 hours). The platelet function analyzer (PFA-100, Dade Behring, Newark, Delaware), a test that has replaced the bleeding time in many clinical settings, was used.
  
  
  RESULTS
  All participants exhibited normal platelet function before starting ibuprofen. Platelet dysfunction was apparent after completion of the ibuprofen course in 7 of the 11 participants and normalized by 24 hours after the last ibuprofen dose.
  
  
  CONCLUSIONS
  The sample size in this study was small, and no participants had a major illness. Correlation between PFA-100 results and clinical bleeding has not been established.
  
  
  CONCLUSIONS
  Platelet function seems to normalize within 24 hours after cessation of regular ibuprofen use in healthy individuals. Further studies are warranted to provide a rational basis for timing of NSAID withdrawal in a range of patients undergoing surgery.
authors.affiliation: Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Health Sciences Center, Aurora, Colorado 80045-0507, USA. neil.goldenberg@uchsc.edu
authors.forename: Neil A
authors.initials: NA
authors.lastname: Goldenberg
authors.forename: Linda
authors.initials: L
authors.lastname: Jacobson
authors.forename: Marilyn J
authors.initials: MJ
authors.lastname: Manco-Johnson
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D003278:Contraceptives, Oral, Hormonal / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003278:Contraceptives, Oral, Hormonal; D007052:Ibuprofen