Synthesis of 15R-PGD2: a potential DP2 receptor agonist.
The first total synthesis of 15R-PGD(2)3 was accomplished. The approach used in this report is also an efficient method to produce 15R-PGE(2). 15R-PGD(2), a potential DP(2) receptor agonist, could be an important novel tool for defining the role of this receptor in inflammatory diseases.
Kim
Seongjin
S
Claude Pepper Institute and Department of Chemistry, Florida Institute of Technology, 150 W. University Blvd., Melbourne, FL 32901, USA.
Bellone
Sophie
S
Maxey
Kirk M
KM
Powell
William S
WS
Lee
Gue-Jae
GJ
Rokach
Joshua
J
D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism*; D007536:Isomerism; D015230:Prostaglandin D2 / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D011971:Receptors, Immunologic / Q000819:agonists* / Q000378:metabolism; D011982:Receptors, Prostaglandin / Q000819:agonists* / Q000378:metabolism; D013329:Structure-Activity Relationship
D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin; C470438:15-methylprostaglandin D2; D000242:Cyclic AMP; D015230:Prostaglandin D2; C036293:prostaglandin D2 receptor