[Radical formation by grinding of commercial tablets according to hospital and pharmacy prescription].
We examined mechanoradical formation in the grinding process of commercial tablets using electron spin resonance (ESR). Mechanoradicals were detected in all tested samples (23 types of commercial tablets) when the ball-milling of tablets was conducted under anaerobic conditions and some were fairly stable even in air. Thus the grinding may cause changes in the physicochemical properties of ingredients included in commercial tablets. Because high quality is demanded in pharmaceuticals, these results suggest more caution should be taken in the grinding of commercial tablets in hospitals and pharmacies.
Kuzuya
Masayuki
M
Laboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University, Gifu 502-8585, Japan. kuzuya@gifu-pu.ac.jp
Kondo
Shin-ichi
S
Ishikawa
Takaaki
T
Furuta
Youji
Y
Aramaki
Hideki
H
Sasai
Yasushi
Y
Yamauchi
Yukinori
Y
D000277:Adjuvants, Pharmaceutic; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D004339:Drug Compounding; D011307:Drug Prescriptions; D004355:Drug Stability; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals / Q000032:analysis*; D019563:Mechanics; D010316:Particle Size; D013607:Tablets / Q000737:chemistry*
D000277:Adjuvants, Pharmaceutic; D005609:Free Radicals; D013607:Tablets