title: Solid-supported reagents and catalysts for the preparation of large ring compounds.
abstract: Parallel combinatorial synthesis in solution using immobilized reagents, catalysts, and scavengers has emerged as a powerful technique for the preparation of diverse libraries of compounds. This technique has only recently been applied to the synthesis of large-ring compounds. In this comprehensive review several strategies are presented and discussed, including Pd-catalyzed allylic alkylation, Stille-coupling, macrolactonization and macrolactamization using solid supported reagents and catalysts. In several cases site isolation has allowed operation, of these macrocyclization reactions in concentrated solution (pseudo-dilution effect).
authors.affiliation: Fachbereich Chemie, University Dortmund, Dortmund, Germany.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Gonthier
authors.forename: Rolf
authors.initials: R
authors.lastname: Breinbauer
mesh_terms: D002384:Catalysis; D006573:Heterocyclic Compounds, 1-Ring / Q000138:chemical synthesis* / Q000737:chemistry*; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation
chemical_list: D006573:Heterocyclic Compounds, 1-Ring; D007202:Indicators and Reagents