Isolation of swinholide A and related glycosylated derivatives from two field collections of marine cyanobacteria.
[structure: see text] Chemical investigation of two field collections of marine cyanobacteria has led to the discovery of two new cytotoxic natural products, ankaraholides A (2) and B (3), along with the known compound swinholide A (1). Since swinholide-type compounds were previously localized to the heterotrophic bacteria of sponges, these findings raise intriguing questions about their true metabolic source.
Andrianasolo
Eric H
EH
College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, USA.
Gross
Harald
H
Goeger
Douglas
D
Musafija-Girt
Mirjam
M
McPhail
Kerry
K
Leal
Rachel M
RM
Mooberry
Susan L
SL
Gerwick
William H
WH
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000458:Cyanobacteria / Q000737:chemistry*; D005367:Fiji; D006031:Glycosylation; D008387:Marine Toxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013559:Symbiosis
D000970:Antineoplastic Agents; D008387:Marine Toxins; D011714:Pyrans; C506852:ankaraholide A; C506853:ankaraholide B; C086235:swinholide A