title: Measuring EGJ opening patterns using high resolution intraluminal impedance.
abstract: The aim of this study was to adapt impedance methodology to study esophagogastric junction (EGJ) sphincter opening and compare opening patterns of the EGJ during deglutitive LES relaxation (dLESR) and transient LES relaxation (tLESR). We studied eight healthy subjects with a novel 12-lumen combined impedance/manometry catheter, the main element of which was a 6 cm sleeve sensor with six side hole sensors and six impedance rings spaced at 1 cm increments along its length. Subjects underwent an air infusion protocol after standard assessment and data tracings and isocontour plots were analysed to assess opening characteristics of the EGJ during dLESRs and tLESRs. Our results revealed that during dLESR the opening pattern was top to bottom, occurred in 0-2.7 s and in 29 of 35 (83%) cases the leading edge of the bolus was liquid. Opening during tLESR began between -7.8 and +8.6 s relative to the onset of nadir LES relaxation. The opening pattern during tLESR was bottom to top, occurred in 0-7.7 s, and in 22 of 29 (76%) the leading edge was liquid. These results support that impedance monitoring can be adapted to identify sphincter opening, to distinguish sphincter opening from sphincter relaxation, and to determine luminal contents during the opening period.
authors.affiliation: Department of Medicine, Northwestern University, The Feinberg School of Medicine, 676 N. St Clair Street, Suite 1400, Chicago, IL 60611, USA. j-pandolfino@northwestern.edu
authors.forename: J E
authors.initials: JE
authors.lastname: Pandolfino
authors.forename: G
authors.initials: G
authors.lastname: Shi
authors.forename: Q
authors.initials: Q
authors.lastname: Zhang
authors.forename: S
authors.initials: S
authors.lastname: Ghosh
authors.forename: J G
authors.initials: JG
authors.lastname: Brasseur
authors.forename: P J
authors.initials: PJ
authors.lastname: Kahrilas
mesh_terms: D000328:Adult; D002404:Catheterization / Q000295:instrumentation; D003679:Deglutition / Q000502:physiology*; D049630:Esophageal Sphincter, Lower / Q000502:physiology*; D004943:Esophagogastric Junction / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry; D010992:Plethysmography, Impedance / Q000295:instrumentation* / Q000379:methods*