Asymmetric synthesis of novel tetrahydroquinoline derivatives with a sugar building block and their bioactivities.
Some novel spiro-tetrahydroquinolines were stereoselectively synthesized by using keto-sugar derived from sucrose as a building block in one pot under mild conditions. The in vitro immunobiological activity and cytotoxicity of these novel tetrahydroquinolines were investigated. The results implied that these spiro-compounds have obvious bioactivity and may be structurally modified to improve bioactivity further.
Liu
Hong-Min
HM
Department of Chemistry, Zhengzhou University, 75, Daxue Road, Zhengzhou 450052, PR China. liuhm@public.zz.ha.cn
Liu
Feng-Wu
FW
Zou
Da-Peng
DP
Dai
Gui-Fu
GF
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002241:Carbohydrates / Q000737:chemistry*; D045744:Cell Line, Tumor; D003500:Cyclization; D006801:Humans; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D002241:Carbohydrates; D011804:Quinolines