title: In vitro effects of spectinomycin and ceftriaxone alone or in combination with other antibiotics against Chlamydia trachomatis.
abstract: The in vitro effects of spectinomycin and ceftriaxone, alone or in combination with erythromycin, ofloxacin, and doxycycline, against Chlamydia trachomatis were investigated by the checkerboard method and compared by Ridit (reference identical unit) analysis. A combination of spectinomycin with erythromycin or doxycycline was found to be more effective than that of ceftriaxone.
authors.affiliation: National Center for STD and Leprosy control, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China.
authors.forename: Shuxian
authors.initials: S
authors.lastname: Shang
authors.forename: Longqing
authors.initials: L
authors.lastname: Xia
authors.forename: Mingying
authors.initials: M
authors.lastname: Zhong
authors.forename: Jinping
authors.initials: J
authors.lastname: Zhang
authors.forename: Jianbin
authors.initials: J
authors.lastname: Zhao
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Gong
authors.forename: David
authors.initials: D
authors.lastname: Mabey
authors.forename: Qianqiu
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002443:Ceftriaxone / Q000494:pharmacology*; D002692:Chlamydia trachomatis / Q000187:drug effects*; D004318:Doxycycline / Q000494:pharmacology; D004336:Drug Antagonism; D004357:Drug Synergism; D004917:Erythromycin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000379:methods; D015242:Ofloxacin / Q000494:pharmacology; D000198:Spectinomycin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D004917:Erythromycin; D002443:Ceftriaxone; D000198:Spectinomycin; D015242:Ofloxacin; D004318:Doxycycline