Liver fibrosis caused by choledocholith to regress after biliary drainage.
OBJECTIVE
To study the correlation between liver fibrosis severity and biliary drainage in patients with choledocholith.


METHODS
A follow-up study on seven patients with liver fibrosis due to choledocholith was made. The data, including biochemical tests (aspartate aminotransferase, alanine aminotransferase) and liver histological features before and after biliary drainage, were collected and studied. The fibrosis severity was scored on a scale from 0 to 3, with 0 denoting none, 1 portal and periportal fibrosis, 2 the presence of numerous fiber septa, and 3 cirrhosis. The average liver fibrosis severity scores of the first and second biopsy were compared with statistical method.


RESULTS
The first, second liver fibrosis severity scores of these seven patients were 2,1; 2,1; 1,0; 1,1; 2,1; 2,1; 1,0 respectively. The results showed that the average liver fibrosis severity score of the second liver biopsy decreased significantly compared with the first liver biopsy (n = 7, t = 4.25, P<0.05).


CONCLUSIONS
Liver fibrosis due to choledocholith may regress after biliary drainage.
Chen
Zuo-Bing
ZB
Department of Emergency Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qing-chun Road, Hangzhou 310003, Zhejiang Province, China. chenzuobing@hotmail.com
Zheng
Shu-Sen
SS
Hu
Guo-Zhi
GZ
Gao
Yuan
Y
Ding
Chen-Yan
CY
Zhang
Yun
Y
Zhao
Xue-Hong
XH
Ni
Lin-Mei
LM
D000328:Adult; D001652:Bile Ducts; D042883:Choledocholithiasis / Q000150:complications* / Q000473:pathology / Q000601:surgery*; D004322:Drainage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008103:Liver Cirrhosis / Q000209:etiology* / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index