title: Antibacterial and antifungal activities of new pyrazolo[3,4-d]pyridazin derivatives.
abstract: Several new pyrazolo[3,4-d]pyridazin derivatives were prepared by the reaction of two [corrected] 1H-pyrazole-3-carboxylic acids and various hydrazines. The compounds were tested for antimicrobial activities against Gram-negative, Gram-positive bacteria and fungi. The compounds named as 7e, f had the highest antimicrobial activities against Gram-negative, Gram-positive bacteria and fungi with minimum inhibitory concentrations in the range of 0.31 to<0.0024 mg ml(-1) .
authors.affiliation: Organic Chemistry Division, Chemistry Department, Faculty of Arts and Sciences, Yuzuncu Yil University, 65080 Van, Turkey. esvakbas@hotmail.com
authors.forename: Esvet
authors.initials: E
authors.lastname: Akbas
authors.forename: Ismet
authors.initials: I
authors.lastname: Berber
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011724:Pyridazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D011720:Pyrazoles; D011724:Pyridazines; C502763:pyrazolo(3,4-d)pyridazin