[Expression of the cerbB-2 (HER-2/neu) oncoprotein in prostatic adenocarcinoma].
OBJECTIVE
Our aim is to determine the expression of the cerbB-2 oncoprotein in prostate cancers using an immunohistochemistry staining and to compare these results with several clinical and histological prognostic factors.


METHODS
An immunohistochemical staining using the cerbB-2 monoclonal antibody (Dako) was performed in 32 radical prostatectomy specimens diagnosed of adenocarcinoma. The intensity of cerbB-2 expression was evaluated with a scale that variated from 0 (no staining) to 3+ (strong complete membrane staining) according to published guidelines. Association of cerbB-2 index immunoreactivity with clinical and histological prognostic factors was examined.


RESULTS
Definite positive membranous staining was detected in 14 of 32 neoplastic cases (44%). Such overexpression was correlated with higher Gleason grade (p=0.04) and higher stage of disease (p=0.038).


CONCLUSIONS
1) This study shows that 44% of all prostate cancer express the cerbB-2 oncoprotein with immunohistochemical technique. 2) These findings suggest that is necessary to standardize the immunohistochemical staining procedure with cerbB-2 in prostate adenocarcinoma. 3) The level of cerbB-2 expression was correlated with Gleason grade and clinical stage.
San Miguel Fraile
P
P
Servicio de Anatomía Patológica, Centro Médico POVISA, Vigo, Pontevedra.
Dos Santos
J E
JE
Pélaez Boismorand
E
E
Ortiz Rey
J A
JA
Iglesias Rodríguez
B
B
Cambronero Santos
J
J
Fajardo Seijo
J L
JL
Rodríguez Costas
J M
JM
Fernández Regueiro
M
M
D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D000368:Aged; D001706:Biopsy; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D012189:Retrospective Studies; D014463:Ultrasonography
D018719:Erb-b2 Receptor Tyrosine Kinases