title: Semi-synthesis and biological evaluation of analogues of UK-2A, a novel antifungal antibiotic from Streptomyces sp. 517-02.
abstract: Several analogues of UK-2A, a novel antifungal antibiotic isolated from Streptomyces sp. 517-02, were semi-synthesized for structure-activity studies. In vitro antifungal activities of these compounds against Saccharomyces cerevisiae IFO 0203 were evaluated by the conventional paper disk method. Several derivatives exhibited growth inhibitory activity similar to UK-2A.
authors.affiliation: Department of Material Science, Graduate School of Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan. usuki@sci.osaka-cu.ac.jp <usuki@sci.osaka-cu.ac.jp>
authors.forename: Yoshinosuke
authors.initials: Y
authors.lastname: Usuki
authors.forename: Koichi
authors.initials: K
authors.lastname: Mitomo
authors.forename: Noriko
authors.initials: N
authors.lastname: Adachi
authors.forename: Xu
authors.initials: X
authors.lastname: Ping
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Fujita
authors.forename: Osamu
authors.initials: O
authors.lastname: Sakanaka
authors.forename: Katsuharu
authors.initials: K
authors.lastname: Iinuma
authors.forename: Hideo
authors.initials: H
authors.lastname: Iio
authors.forename: Makoto
authors.initials: M
authors.lastname: Taniguchi
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D007783:Lactones / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000254:growth & development; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D007783:Lactones; D011725:Pyridines; C101439:UK 2A