title: Synthesis of novel amino and acetyl amino-4-methylcoumarins and evaluation of their antioxidant activity.
abstract: The six novel 4-methylcoumarins bearing different functionalities such as amino, hydroxy, N-acetyl, acetoxy and nitro have been synthesized and confirmed on the basis of their spectral data (1H-, 13C-NMR, UV, IR and EI mass). They were examined for the first time for their effect on NADPH dependent liver microsomal lipid peroxidation in vitro, and the results were compared with other model 4-methylcoumarin derivatives to establish the structure-activity relationship. Our studies demonstrated that amino group is an effective substitute for the hydroxyl group for antioxidant property and produced a dramatic inhibition of lipid peroxidation. Ortho dihydroxy and ortho hydroxy-amino coumarins were found to possess highest antioxidant and radical scavenging activities.
authors.affiliation: Department of Biochemistry, VP Chest Institute, University of Delhi, Delhi 110 007, India.
authors.forename: Yogesh K
authors.initials: YK
authors.lastname: Tyagi
authors.forename: Ajit
authors.initials: A
authors.lastname: Kumar
authors.forename: Hanumantharao G
authors.initials: HG
authors.lastname: Raj
authors.forename: Parag
authors.initials: P
authors.lastname: Vohra
authors.forename: Garima
authors.initials: G
authors.lastname: Gupta
authors.forename: Ranju
authors.initials: R
authors.lastname: Kumari
authors.forename: Pankaj
authors.initials: P
authors.lastname: Kumar
authors.forename: Rajinder K
authors.initials: RK
authors.lastname: Gupta
mesh_terms: D000107:Acetylation; D000586:Amination; D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008745:Methylation; D015394:Molecular Structure; D009249:NADP / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D003374:Coumarins; D009249:NADP