Frequency of glucose-6-phosphate dehydrogenase deficiency in some ethnic groups of Pakistan.
OBJECTIVE
To determine the frequency of G6PD deficiency in young healthy adult males of some ethnic groups in Pakistan.


METHODS
Descriptive study.


METHODS
Study performed in Combined Military Hospital, Attock in collaboration with Armed Forces Institute of Pathology, Rawalpindi from October 2003 to January 2004.


METHODS
Asymptomatic and healthy adult males were included in the study. A brief clinical record including age, ethnic group, place of residence, and history of past illnesses including fever, episodes of recurrent jaundice were recorded. Met-hemoglobin reduction test for G6PD screening was performed. Hemoglobin, red cell indices and total leukocyte count of G6PD deficient cases were measured on Sysmex KX 32 hematology analyzer.


RESULTS
Three thousand adult males with age between 17 years to 23 years were screened. G6PD deficiency was detected in 1.8%. Deficiency state was 1.07% in Kashmiris, 1.47% in Punjabis, 2.77% in Sindhis, and 3.17% in Pathans. Past history of recurrent jaundice was present in 5.7%. Mild anemia was present in 3.8%.


CONCLUSIONS
Frequency of G6PD deficiency was 1.8% in young healthy adults with insignificant difference among various ethnic groups except in Pathans.
Ali
Nadir
N
Department of Pathology, Combined Military Hospital, Attock, Pakistan. nmjrm@hotmail.com
Anwar
Masood
M
Ayyub
Mohammad
M
Bhatti
Farhat Abbas
FA
Nadeem
Mansoor
M
Nadeem
Asif
A
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D015331:Cohort Studies; D005006:Ethnicity / Q000706:statistics & numerical data*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000175:diagnosis* / Q000208:ethnology*; D006403:Hematologic Tests; D006801:Humans; D008297:Male; D010154:Pakistan / Q000453:epidemiology; D015995:Prevalence; D011379:Prognosis; D012016:Reference Values; D012720:Severity of Illness Index; D017678:Sex Distribution
D005954:Glucosephosphate Dehydrogenase