title: Towards a new conceptual approach to "parasitoproteomics".
abstract: Many parasitologists are betting heavily on proteomic studies to explain biochemical host-parasite interactions and, thus, to contribute to disease control. However, many "parasitoproteomic" studies are performed with powerful techniques but without a conceptual approach to determine whether the host genomic responses during a parasite infection represent a nonspecific response that might be induced by any parasite or any other stress. In this article, a new conceptual approach, based on evolutionary concepts of immune responses of a host to a parasite, is suggested for parasitologists to study the host proteome reaction after parasite invasion. Also, this new conceptual approach can be used to study other host-parasite interactions such as behavioral manipulation.
authors.affiliation: GEMI, UMR CNRS, IRD 2724, IRD, 911 Avenue Agropolis BP 64501, 34394 Montpellier Cedex 5, France. biron@mpl.ird.fr
authors.forename: David G
authors.initials: DG
authors.lastname: Biron
authors.forename: Hercules
authors.initials: H
authors.lastname: Moura
authors.forename: Laurent
authors.initials: L
authors.lastname: Marché
authors.forename: Austin L
authors.initials: AL
authors.lastname: Hughes
authors.forename: Frédéric
authors.initials: F
authors.lastname: Thomas
mesh_terms: D000818:Animals; D020869:Gene Expression Profiling; D006790:Host-Parasite Interactions; D006801:Humans; D010271:Parasites / Q000235:genetics*; D040901:Proteomics / Q000379:methods*