title: Role of the Rep helicase gene in homologous recombination in Neisseria gonorrhoeae.
abstract: In Escherichia coli, the Rep helicase has been implicated in replication fork progression, replication restart, homologous recombination, and DNA repair. We show that a Neisseria gonorrhoeae rep mutant is deficient in the homologous-recombination-mediated processes of DNA transformation and pilus-based colony variation but not in DNA repair.
authors.affiliation: Department of Microbiology and Immunology, Northwestern University Feinberg University School of Medicine, 303 East Chicago Ave., Chicago, IL 60611, USA.
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Kline
authors.forename: H Steven
authors.initials: HS
authors.lastname: Seifert
mesh_terms: D000595:Amino Acid Sequence; D004249:DNA Damage / Q000235:genetics; D004265:DNA Helicases / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000235:genetics; D008969:Molecular Sequence Data; D009344:Neisseria gonorrhoeae / Q000235:genetics*; D011995:Recombination, Genetic; D014169:Transformation, Bacterial
chemical_list: D004268:DNA-Binding Proteins; D004265:DNA Helicases