Changes in electric charge and phospholipids composition in erythrocyte membrane of ethanol--poisoned rats after administration of teas.
Erythrocyte membrane components and electric charge can be modified by ethanol and by compounds formed as a result of its metabolism, particularly be reactive oxygen species (ROS). The effects of ROS can be neutralized by administering preparations with antioxidant properties. The natural preparations of this kind are teas. For this reason, it has been the purpose of this work to determine effect of green and black tea on membrane electric charge and phospholipids composition of an erythrocyte membrane from rats intoxicated with ethanol. Electrophoresis technique and HPLC have been applied to the above-mentioned studies. Ethanol administration caused an increase in erythrocyte surface charge density and phospholipids composition in the membrane. Administration of green and black tea with ethanol to the rats partially neutralizes the changes provoked by ethanol, and the action of green tea was stronger than that of black tea.
Dobrzyńska
Izabela
I
Institute of Chemistry, University in Białystok, Białystok.
Szachowicz-Petelska
Barbara
B
Skrzydlewska
Elzbieta
E
Figaszewski
Zbigniew Artur
ZA
D000818:Animals; D002492:Central Nervous System Depressants / Q000506:poisoning*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D000431:Ethanol / Q000506:poisoning*; D008297:Male; D010743:Phospholipids / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D013662:Tea
D002492:Central Nervous System Depressants; D010743:Phospholipids; D013662:Tea; D000431:Ethanol