title: Effect of hyperprolinemia on acetylcholinesterase and butyrylcholinesterase activities in rat.
abstract: We observed here that acute proline (Pro) administration provoked a decrease (32%) of acetylcholinesterase (AChE) activity in cerebral cortex and an increase (22%) of butyrylcholinesterase (BuChE) activity in the serum of 29-day-old rats. In contrast, chronic administration of Pro did not alter AChE or BuChE activities. Furthermore, pretreatment of rats with vitamins E and C combined or alone, N(omega)-nitro-L-arginine methyl ester or melatonin prevented the reduction of AChE activity caused by acute Pro administration, suggesting the participation of oxidative stress in such effects.
authors.affiliation: Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: D
authors.initials: D
authors.lastname: Delwing
authors.forename: F
authors.initials: F
authors.lastname: Chiarani
authors.forename: C M D
authors.initials: CM
authors.lastname: Wannmacher
authors.forename: M
authors.initials: M
authors.lastname: Wajner
authors.forename: A T S
authors.initials: AT
authors.lastname: Wyse
mesh_terms: D000110:Acetylcholinesterase / Q000009:adverse effects*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002091:Butyrylcholinesterase / Q000097:blood*; D002525:Cerebellar Cortex / Q000201:enzymology*; D008659:Metabolic Diseases / Q000097:blood* / Q000139:chemically induced; D018384:Oxidative Stress / Q000187:drug effects; D011392:Proline / Q000008:administration & dosage / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D011392:Proline; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase