[Correlation between APOA gene polymorphism and intracranial aneurysm].
OBJECTIVE
To study the correlation between a pentanucleotide repeats (PNR) polymorphism of APOA and the genesis of intracranial aneurysm.


METHODS
Fifty-eight patients with intracranial aneurysms diagnosed by angiography and 58 healthy controls were enrolled in our study. The gene polymorphism of APOA PNR were detected by polymerase chain reaction (PCR) and non-denatured polyacrylamide gels electropherosis (PAGE).


RESULTS
Eight kinds of gene types and 6 kinds of alleles were found in these two groups. There were two sites of sequence variance in the 5' control region of APOA gene, which were significantly different between the patients and controls.


CONCLUSIONS
Correlation may exist between intracranial aneurysm and APOA gene.
Zhao
Yuan-li
YL
Department of Neurosurgery, Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing 100050, China. zhaoyljt@public3.bta.net.cn
Sun
Yu-ming
YM
Wang
Shuo
S
Zhao
Ji-zong
JZ
Chen
Bao-sheng
BS
D000328:Adult; D000368:Aged; D000483:Alleles; D001054:Apolipoproteins A / Q000235:genetics*; D044466:Asian People; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D002532:Intracranial Aneurysm / Q000235:genetics*; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D011110:Polymorphism, Genetic
D001054:Apolipoproteins A; D004247:DNA