Detection of interleukin 10 in cerebrospinal fluid of patients with subacute sclerosing panencephalitis.
Subacute sclerosing panencephalitis (SSPE) is a neurodegenerative disorder due to persistent measles virus infection, with high level of measles-specific antibodies in cerebrospinal fluid (CSF). To analyze whether such response arises from a TH2-biased response, the authors determined TH1 (interferon [IFN]-gamma) and TH2 (interleukin [IL]-4 and IL-10) cytokines in CSF, taken at diagnosis, of eight SSPE patients (median age, 57.5 month, range 42 to 76 months). All patients presented IL-10 (median 29.3 pg/ml, range 4.3 to 162 pg/ml), but not IL-4 (<10 pg/ml); only one case showed IFN-gamma (162 pg/ml). These results are consistent with a TH2 bias or with a local, anti-inflammatory or neuroprotective mechanism involving IL-10.
Mistchenko
A S
AS
Laboratorio de Virología, Hospital de Niños R. Gutiérrez, Gallo 1330, 1425 Buenos Aires, Argentina. virologia@velocom.com.ar
Fornari
M C
MC
Viegas
M
M
Barrero
P R
PR
Diez
R A
RA
D017668:Age of Onset; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007371:Interferon-gamma / Q000134:cerebrospinal fluid; D016753:Interleukin-10 / Q000134:cerebrospinal fluid*; D015847:Interleukin-4 / Q000134:cerebrospinal fluid; D008297:Male; D008459:Measles virus / Q000276:immunology; D013344:Subacute Sclerosing Panencephalitis / Q000134:cerebrospinal fluid* / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology
D016753:Interleukin-10; D015847:Interleukin-4; D007371:Interferon-gamma