T-cell lymphoblastic leukemia/lymphoma syndrome with eosinophilia and acute myeloid leukemia.
This case represents an example of an unusual T-cell lymphoblastic leukemia/lymphoma syndrome associated with eosinophilia and myeloid malignancy in a young boy. This case is one of only five reported "leukemic" variants of the disease and demonstrates the importance of considering this poor prognostic diagnosis in pediatric acute lymphoblastic leukemia. This case also illustrates the importance of an interactive multidisciplinary approach to the laboratory evaluation of a leukemia patient.
Lamb
Lawrence S
LS
Department of Pediatrics, Division of Hematology and Oncology, University of South Carolina School of Medicine, Columbia, South Carolina, USA. lslamb@uambmc.edu
Neuberg
Ronnie
R
Welsh
Jeff
J
Best
Robert
R
Stetler-Stevenson
Maryalice
M
Sorrell
April
A
D000954:Antigens, Surface / Q000096:biosynthesis; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D002648:Child; D003582:Cytogenetics; D004802:Eosinophilia / Q000150:complications* / Q000628:therapy; D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000628:therapy; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications* / Q000628:therapy; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000150:complications* / Q000628:therapy; D008297:Male; D011379:Prognosis; D012074:Remission Induction; D013577:Syndrome
D000954:Antigens, Surface