title: Identification of hippocampus-related candidate genes for Alzheimer's disease.
abstract: Alzheimer's disease (AD) is a complex multifactorial disease in which many genetic and environmental factors are involved. We performed an association study using 376 AD patients and 376 control subjects. We studied 35 single nucleotide polymorphisms in 35 genes that were significantly downregulated or upregulated only in the AD hippocampus compared with control and found that 9 single nucleotide polymorphisms were associated with AD. Our data indicated that single nucleotide polymorphisms could highly reflect differences in gene expression. Furthermore, an intronic polymorphism (+9943T/C) in POU2F1 was most significantly associated with AD (p = 0.0007). Our results suggest that POU2F1 is a candidate gene for AD.
authors.affiliation: Department of Geriatric Medicine, Ehime University School of Medicine, National University Corporation, Ehime, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Taguchi
authors.forename: Hidehisa D
authors.initials: HD
authors.lastname: Yamagata
authors.forename: Wangtao
authors.initials: W
authors.lastname: Zhong
authors.forename: Kouzin
authors.initials: K
authors.lastname: Kamino
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Akatsu
authors.forename: Ryuji
authors.initials: R
authors.lastname: Hata
authors.forename: Takayuki
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Kenji
authors.initials: K
authors.lastname: Kosaka
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Takeda
authors.forename: Ikuko
authors.initials: I
authors.lastname: Kondo
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Miki
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D004268:DNA-Binding Proteins; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D008297:Male; D050811:Octamer Transcription Factor-1; D020641:Polymorphism, Single Nucleotide; D014157:Transcription Factors
chemical_list: D004268:DNA-Binding Proteins; D050811:Octamer Transcription Factor-1; C494165:POU2F1 protein, human; D014157:Transcription Factors