title: Chromosome intra- and inter-changes determined by G-banding in radiation workers with in vivo exposure to plutonium.
abstract: Suggestions that exposure to intakes of alpha-emitting radionuclides such as plutonium could result in a specific profile of chromosome damage distinguishable from that of low LET irradiation have led to the re-analysis of the different types of chromosome aberrations in peripheral blood lymphocytes determined by G-banding in a group of 20 plutonium workers from the British Nuclear Fuels plc facility at Sellafield, UK. Comparisons were made with a group of workers with negligible plutonium intakes but similar external gamma doses and with an unexposed control group. Examination of simple translocation frequencies in the three groups indicated a significant difference (P = 0.033), with the higher frequency in the plutonium workers indicating that exposure from plutonium was contributing to the aberration yield. Slightly raised frequencies of both intra-chromosomal and complex aberrations were observed in the plutonium workers in comparison with the comparable external exposure group and the control group but the difference did not reach significance at the P = 0.05 level and there was no variation in the relative frequencies of the different aberration types between the three groups. There was, therefore, no firm indication from this study that either intra-chromosomal or complex aberrations could be used as a specific marker of high LET exposure in workers with historical intakes of plutonium.
authors.affiliation: Genetics Department, Westlakes Research Institute, Moor Row, Cumbria, UK.
authors.forename: E Janet
authors.initials: EJ
authors.lastname: Tawn
authors.forename: Caroline A
authors.initials: CA
authors.lastname: Whitehouse
mesh_terms: D001822:Body Burden; D016009:Chi-Square Distribution; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D004739:England; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008214:Lymphocytes; D016273:Occupational Exposure / Q000009:adverse effects*; D011005:Plutonium / Q000009:adverse effects* / Q000493:pharmacokinetics; D011829:Radiation Dosage
chemical_list: D011005:Plutonium