title: On the mutation rate of herpes simplex virus type 1.
abstract: All seven DNA-based microbes for which carefully established mutation rates and mutational spectra were previously available displayed a genomic mutation rate in the neighborhood of 0.003 per chromosome replication. The pathogenic mammalian DNA virus herpes simplex type 1 has an estimated genomic mutation rate compatible with that value.
authors.affiliation: Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709-2233, USA. drake@nichs.nih.gov
authors.forename: John W
authors.initials: JW
authors.lastname: Drake
authors.forename: Charles B C
authors.initials: CB
authors.lastname: Hwang
mesh_terms: D000818:Animals; D004247:DNA / Q000235:genetics; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase; D017353:Gene Deletion; D005787:Gene Frequency; D016678:Genome; D018259:Herpesvirus 1, Human / Q000235:genetics*; D006801:Humans; D009154:Mutation; D020125:Mutation, Missense; D016366:Open Reading Frames; D011995:Recombination, Genetic; D013045:Species Specificity
chemical_list: D004247:DNA; D004259:DNA-Directed DNA Polymerase