title: Quantitative assessment of right ventricular systolic function by the analysis of right ventricular contrast time-intensity curve.
abstract: To study reliability and reliable indices of quantitative assessment of right ventricular systolic function by time-intensity curve (TIC) with right ventricular contrast, 5% sonicated human albumin was injected intravenously at a does of 0.08 ml/kg into 10 dogs at baseline status and cardiac insufficiency. Apical four-chamber view was observed for washin and washout of contrast agent from right ventricle. The parameters of TIC were obtained by curve fitting. The differences of parameters were analyzed in different states of cardiac functions. Among the parameters derived from TIC, the time constant (k) was decreased significantly with decline of cardiac function (P<0.001). But half-time of decent of peak intensity (HT) and mean-transit-time (MTT) of washout were increased significantly (P<0.001). The k was strongly related to cardiac output of right ventricle (CO) and ejection fraction (EF) of left ventricle and fractional shortening (FS) of left ventricle. Right ventricular systolic function could be assessed reliably by the parameters derived from TIC with right ventricular contrast echocardiography. The k, HT and MTT are reliable indices for quantitative assessment of right ventricular systolic function.
authors.affiliation: Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Youbin
authors.initials: Y
authors.lastname: Deng
authors.forename: Tianliang
authors.initials: T
authors.lastname: Li
authors.forename: Haoyi
authors.initials: H
authors.lastname: Yang
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D002302:Cardiac Output; D003287:Contrast Media; D004285:Dogs; D004452:Echocardiography; D007091:Image Processing, Computer-Assisted; D007201:Indicator Dilution Techniques; D015203:Reproducibility of Results; D013599:Systole; D016278:Ventricular Function, Right / Q000502:physiology*
chemical_list: D003287:Contrast Media