title: [Prostate leiomiosarcoma. Report of three cases].
abstract: OBJECTIVE
  Leiomyosarcoma of the prostate is an uncommon neoplasm with a poor prognosis. We review the three cases of leiomyosarcoma of the prostate observed in our hospital in the last twenty years and studied their clinical follow-up,
  
  
  METHODS
  We have found three cases and we have studied their clinical follow-up, immunohistochemical profile and ultrastructural features.
  
  
  RESULTS
  In all cases tumor cells were positive for vimentin and also for either desmin or actin. Two cases were considered grade III sarcomas, with an aggressive course even with treatment, they died 5 and 24 months later, respectively. The third case, was considered grade II and is still alive, 60 months after diagnosis, without evidence of disease.
  
  
  CONCLUSIONS
  Leiomyosarcoma of the prostate is an uncommon neoplasm that accounts for less than 0.1% of prostate tumors. We found no prognostic factors for predicting prolonged survival although complete resection and low mitotic activity may be predictive.
authors.affiliation: Servicio de Anatomía Patológica, Hospital de Navarra, Pamplona, España. ireneyander@wanadoo.es
authors.forename: Irene
authors.initials: I
authors.lastname: Amat Villegas
authors.forename: Raquel
authors.initials: R
authors.lastname: Beloqui Perez
authors.forename: María Cristina
authors.initials: MC
authors.lastname: Caballero Martínez
authors.forename: María Luisa
authors.initials: ML
authors.lastname: Gómez Dorronsoro
authors.forename: Begoña
authors.initials: B
authors.lastname: Larrínaga Liñero
authors.forename: José Angel
authors.initials: JA
authors.lastname: Cuesta Alcalá
authors.forename: Javier
authors.initials: J
authors.lastname: Aldave Villanueva
mesh_terms: D006801:Humans; D007890:Leiomyosarcoma / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000473:pathology