title: Insertion/deletion polymorphism of the ACE gene and adherence to ACE inhibitors.
abstract: OBJECTIVE
  We investigated whether the insertion/deletion (I/D) polymorphism of the ACE gene modified the adherence to ACE inhibitors as measured by the discontinuation of an ACE inhibitor, or addition of another antihypertensive drug.
  
  
  METHODS
  This was a cohort study among 239 subjects who started ACE inhibitor therapy. A Cox proportional hazard model was used to calculate relative risk (RR).
  
  
  RESULTS
  During follow-up there was no significant difference between subjects with the DD, ID or II genotype (DD vs II; RR = 1.17, 95%CI: 0.78, 1.77 and ID vs II; RR = 1.06, 95%CI: 0.73, 1.55) in adherence.
  
  
  CONCLUSIONS
  The I/D polymorphism of the ACE gene does not influence the adherence to ACE inhibitors.
authors.affiliation: Department of Epidemiology & Biostatistics, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Schelleman
authors.forename: O H
authors.initials: OH
authors.lastname: Klungel
authors.forename: C M
authors.initials: CM
authors.lastname: van Duijn
authors.forename: J C M
authors.initials: JC
authors.lastname: Witteman
authors.forename: A
authors.initials: A
authors.lastname: Hofman
authors.forename: A
authors.initials: A
authors.lastname: de Boer
authors.forename: B H Ch
authors.initials: BH
authors.lastname: Stricker
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use; D015331:Cohort Studies; D004251:DNA Transposable Elements / Q000235:genetics*; D017353:Gene Deletion; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000235:genetics; D008875:Middle Aged; D010349:Patient Compliance; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic / Q000235:genetics*; D011446:Prospective Studies; D018570:Risk Assessment
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D004251:DNA Transposable Elements