title: CT volumetry of intravertebral cement after kyphoplasty. Comparison of polymethylmethacrylate and calcium phosphate in a 12-month follow-up.
abstract: This study was intended to measure the volume of intravertebral cement after balloon kyphoplasty with high resolution computed tomography (CT) and dedicated software. Volume changes of biocompatible calcium phosphate cement (CPC) were detected during a follow-up of 12 months. Measurements were compared with a control group of patients treated with polymethylmethacrylate (PMMA). Twenty-three vertebrae (14 CPC, 9 PMMA) of 12 patients were examined with CT using an identical imaging protocol. Dedicated software was used to quantify intravertebral cement volume in subvoxel resolution by analyzing each cement implant with a density-weighted algorithm. The mean volume reduction of CPC was 0.08 ml after 12 months, which corresponds to an absorption rate of 2 vol%. However, the difference did not reach significance level (P>0.05). The mean error estimate was 0.005 ml, indicating excellent precision of the method. CT volumetry appears a precise tool for measurement of intravertebral cement volume. CT volumetry offers the possibility of in vivo measurement of CPC resorption.
authors.affiliation: Department of Diagnostic Radiology, University of Heidelberg, Heidelberg, Germany. martin.libicher@med.uni-heidelberg.de
authors.forename: M
authors.initials: M
authors.lastname: Libicher
authors.forename: M
authors.initials: M
authors.lastname: Vetter
authors.forename: I
authors.initials: I
authors.lastname: Wolf
authors.forename: G
authors.initials: G
authors.lastname: Noeldge
authors.forename: C
authors.initials: C
authors.lastname: Kasperk
authors.forename: I
authors.initials: I
authors.lastname: Grafe
authors.forename: K
authors.initials: K
authors.lastname: Da Fonseca
authors.forename: J
authors.initials: J
authors.lastname: Hillmeier
authors.forename: P J
authors.initials: PJ
authors.lastname: Meeder
authors.forename: H P
authors.initials: HP
authors.lastname: Meinzer
authors.forename: G W
authors.initials: GW
authors.lastname: Kauffmann
mesh_terms: D001843:Bone Cements; D002130:Calcium Phosphates; D005260:Female; D005500:Follow-Up Studies; D050815:Fractures, Compression / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D008159:Lumbar Vertebrae / Q000293:injuries; D008297:Male; D008875:Middle Aged; D019904:Polymethyl Methacrylate; D011446:Prospective Studies; D016103:Spinal Fractures / Q000000981:diagnostic imaging / Q000601:surgery*; D013904:Thoracic Vertebrae / Q000293:injuries; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D001843:Bone Cements; D002130:Calcium Phosphates; D019904:Polymethyl Methacrylate; C020243:calcium phosphate