Insulin-like 6 immunoreactivity in the mouse brain and testis.
Insulin-like 6 immunoreactivity (irINSL6) was detected in Leydig cells of the mouse testis. In the brain, labeled somata were detected mainly in the caudal hypothalamus and midbrain. Double labeling the brainstem sections revealed that irINSL6 somata were 5-hydroxytryptamine (5-HT) positive. The presence of irINSL6 in discrete populations of hypothalamic and brainstem neurons and in Leydig cells of the testis suggests a diverse biological function of this novel peptide.
Brailoiu
G Cristina
GC
Department of Pharmacology, Temple University School of Medicine, 3420 N. Broad Street, Philadelphia, PA 19140, USA.
Dun
Siok L
SL
Yin
Deling
D
Yang
Jun
J
Chang
Jaw Kang
JK
Dun
Nae J
NJ
D000818:Animals; D001921:Brain / Q000378:metabolism; D001923:Brain Chemistry / Q000502:physiology*; D005260:Female; D007150:Immunohistochemistry; D007328:Insulin / Q000031:analogs & derivatives* / Q000032:analysis* / Q000096:biosynthesis; D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D013737:Testis / Q000737:chemistry* / Q000378:metabolism
C512664:Insl6 protein, mouse; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins