title: Diastereoselective synthesis of polysubstituted pyrrolidinone as a key intermediate for the anticancer agents by palladium(II)-catalyzed carboxylation.
abstract: Palladium(II)-catalyzed carboxylation of chiral olefins 6a-d has been examined under various conditions. In the weak basic condition (K2CO3), 7a-d were obtained in good yields. Alternatively, in the strong basic condition, pyrrolidinones 8a-d were obtained resulting in excellent yields and with high diastereoselectivity.
authors.affiliation: College of Pharmacy, SungKyunKwan University, Suwon 440-746, Korea.
authors.forename: Dong-Rack
authors.initials: DR
authors.lastname: Choi
authors.forename: Kee-Young
authors.initials: KY
authors.lastname: Lee
authors.forename: Yun-Sung
authors.initials: YS
authors.lastname: Chung
authors.forename: Jae-Eun
authors.initials: JE
authors.lastname: Joo
authors.forename: Yong-Hyun
authors.initials: YH
authors.lastname: Kim
authors.forename: Chang-Young
authors.initials: CY
authors.lastname: Oh
authors.forename: Yiu-Suk
authors.initials: YS
authors.lastname: Lee
authors.forename: Won-Hun
authors.initials: WH
authors.lastname: Ham
mesh_terms: D000475:Alkenes / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002384:Catalysis; D002850:Chromatography, Gel; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D010165:Palladium / Q000737:chemistry; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000494:pharmacology*; D012997:Solvents; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D011760:Pyrrolidinones; D012997:Solvents; D010165:Palladium