[The effect of borneol on level of HA and 5-HT in rat's hypothalamus].
OBJECTIVE
To observe the effect of borneol on level of HA and 5-HT in rat's hypothalamus.


METHODS
The levels of HA and 5-HT in rat's hypothalamus were determined before and after p.o. with different amount of borneol by high performance liquid chromatography with electrochemical detection (HPLC-ECD), and the borneol's effect on the levels of HA and 5-HT was also studied.


RESULTS
The level of HA in rat's hypothalamus after different dose of borneol were higher than before administration. The level of HA in 20 min group after middle dose increased significantly comparing with before administration (P < 0.01), the others of group after middle dose, the 45 min group after high dose, the 20 and 45 min after low dose were also increased significantly than before administration (P < 0.05). After different dose of borneol, the level of 5-HT in rat's hypothalamus changed as follows: the level of 5-HT after high dose were higher than before administraton (P <0.05 or P < 0.01 ); the level of 5-HT after 5, 20 and 45 min of middle and low dose incrased significantly (P <0.05 or P < 0.01).


CONCLUSIONS
Borneol could increase the levels of HA and 5-HT in rat's hypothalamus.
Li
Weirong
W
Institute of Clinical Pharmacology, Guangzhou University of TCM, Guangzhou.
Yao
Limei
L
Mi
Suiqing
S
Wang
Ningsheng
N
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D001892:Camphanes / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006632:Histamine / Q000032:analysis / Q000378:metabolism*; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000032:analysis / Q000378:metabolism*
D001892:Camphanes; D004365:Drugs, Chinese Herbal; D012701:Serotonin; D006632:Histamine