Hepatic steatosis in transgenic mice overexpressing human histone deacetylase 1.
It is generally thought that histone deacetylases (HDACs) play important roles in the transcriptional regulation of genes. However, little information is available concerning the specific functions of individual HDACs in disease states. In this study, two transgenic mice lines were established which harbored the human HDAC1 gene. Overexpressed HDAC1 was detected in the nuclei of transgenic liver cells, and HDAC1 enzymatic activity was significantly higher in the transgenic mice than in control littermates. The HDAC1 transgenic mice exhibited a high incidence of hepatic steatosis and nuclear pleomorphism. Molecular studies showed that HDAC1 may contribute to nuclear pleomorphism through the p53/p21 signaling pathway.
Wang
Ai-Guo
AG
Laboratory of Human Genomics, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Republic of Korea.
Seo
Sang-Beom
SB
Moon
Hyung-Bae
HB
Shin
Hye-Jun
HJ
Kim
Dong Hoon
DH
Kim
Jin-Man
JM
Lee
Tae-Hoon
TH
Kwon
Ho Jeong
HJ
Yu
Dae-Yeul
DY
Lee
Dong-Seok
DS
D000818:Animals; D001483:Base Sequence; D018797:Cell Cycle Proteins / Q000235:genetics; D050759:Cyclin-Dependent Kinase Inhibitor p21; D017931:DNA Primers; D005234:Fatty Liver / Q000201:enzymology*; D016158:Genes, p53; D006655:Histone Deacetylases / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic
C493956:CDKN1A protein, human; C493957:Cdkn1a protein, mouse; D018797:Cell Cycle Proteins; D050759:Cyclin-Dependent Kinase Inhibitor p21; D017931:DNA Primers; D006655:Histone Deacetylases