title: Advances in atopic dermatitis.
abstract: Atopic dermatitis (AD) is a highly pruritic, chronic, and relapsing inflammatory skin disorder affecting 10-20% of children worldwide. During the past year there have been significant advances in our understanding of the cellular and immunologic mechanisms underlying AD as well as the immunologic triggers involved in its pathogenesis. The introduction of a new class of topical anti-inflammatory medications, topical calcineurin inhibitors, has significantly increased our treatment options and led to the rethinking of potential management approaches in AD.
authors.affiliation: Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA.
authors.forename: Liang-Shiou
authors.initials: LS
authors.lastname: Ou
authors.forename: Donald Y M
authors.initials: DY
authors.lastname: Leung
mesh_terms: D000938:Antigen-Presenting Cells / Q000502:physiology; D065095:Calcineurin Inhibitors; D016207:Cytokines / Q000096:biosynthesis; D003876:Dermatitis, Atopic / Q000276:immunology* / Q000628:therapy*; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D065095:Calcineurin Inhibitors; D016207:Cytokines