DNA photocleavage and biological activity of a pyrene dihydrodioxin.
A pyrene dihydrodioxin has been synthesized, shown to bind to duplex DNA by intercalation, and cleave the phiX 174 supercoiled plasmid upon irradiation with UV light. This compound also exhibits cytotoxic activity at the micromolar range in a number of human cancer cell lines.
Mack
Eric T
ET
Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221-0172, USA.
Birzniece
Dagne
D
Veach
Darren R
DR
Coyle
William
W
Wilson
R Marshall
RM
D045744:Cell Line, Tumor; D004247:DNA / Q000378:metabolism / Q000528:radiation effects*; D004249:DNA Damage; D004147:Dioxins / Q000737:chemistry / Q000378:metabolism / Q000528:radiation effects*; D006801:Humans; D007364:Intercalating Agents / Q000737:chemistry / Q000378:metabolism / Q000528:radiation effects; D020014:K562 Cells; D011721:Pyrenes / Q000737:chemistry / Q000378:metabolism / Q000528:radiation effects*; D014466:Ultraviolet Rays
D004147:Dioxins; D007364:Intercalating Agents; D011721:Pyrenes; D004247:DNA