title: Lymphocyte subsets in term and significantly preterm UK infants in the first year of life analysed by single platform flow cytometry.
abstract: This observational study describes the ranges observed for lymphocyte subsets for significantly preterm infants (<32 weeks) in the first year of life, measured by single platform flow cytometry and compared to identically determined subsets in term infants. After ethical approval 39 term and 28 preterm infants had lymphocyte subset analysis before and after their primary immunization series. Median values with 5th and 95th percentiles of absolute counts and percentages are presented for total lymphocytes, T cells, NK cells, B cells, cytotoxic T cells, helper T cells, dual positive T cells, activated T cells, activated T helper cells (including T regulatory cells), pan memory T cells, pan naive T cells, memory helper T cells, naive helper T cells and the T helper/suppressor ratio. The lymphocyte profile of the preterm infants differed from that of the term infants.
authors.affiliation: Department of Neonatology, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK. jberrington@doctors.org.uk
authors.forename: J E
authors.initials: JE
authors.lastname: Berrington
authors.forename: D
authors.initials: D
authors.lastname: Barge
authors.forename: A C
authors.initials: AC
authors.lastname: Fenton
authors.forename: A J
authors.initials: AJ
authors.lastname: Cant
authors.forename: G P
authors.initials: GP
authors.lastname: Spickett
mesh_terms: D001724:Birth Weight; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D006801:Humans; D007114:Immunization; D007231:Infant, Newborn / Q000276:immunology; D007234:Infant, Premature / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology; D018655:Lymphocyte Count; D016131:Lymphocyte Subsets / Q000276:immunology*; D008297:Male; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology