Comparative efficacies of TAK-187, a long-lasting ergosterol biosynthesis inhibitor, and benznidazole in preventing cardiac damage in a murine model of Chagas' disease.
We carried out a comparative study of benznidazole and TAK-187, a long-lasting ergosterol biosynthesis inhibitor, with a murine model of Chagas' disease. The results indicated that TAK-187 was more effective than benznidazole in preventing Trypanosoma cruzi-induced cardiac damage in experimental animals.
Corrales
Milagros
M
Laboratorio de Patología Experimental, Facultad de Ciencias de la Salud, Universidad Nacional de Salta, Buenos Aires, Salta, Argentina.
Cardozo
Rubén
R
Segura
María Asunción
MA
Urbina
Julio A
JA
Basombrío
Miguel Angel
MA
D000208:Acute Disease; D000818:Animals; D002598:Chagas Cardiomyopathy / Q000517:prevention & control*; D014355:Chagas Disease / Q000188:drug therapy* / Q000469:parasitology; D004195:Disease Models, Animal; D004875:Ergosterol / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D008297:Male; D051379:Mice; D009593:Nitroimidazoles / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D014349:Trypanosoma cruzi / Q000187:drug effects / Q000472:pathogenicity; D005466:Fluorocarbons
D004875:Ergosterol; D009593:Nitroimidazoles; D014230:Triazoles; D014344:Trypanocidal Agents; C105227:TAK 187; D005466:Fluorocarbons; C009999:benzonidazole