Transhepatic fibrinolysis of mesenteric and portal vein thrombosis in a patient with ulcerative colitis: a case report.
OBJECTIVE
To present a case of acute mesenteric and portal vein thrombosis treated with thrombolytic therapy in a patient with ulcerative colitis in acute phase and to review the literature on thrombolytic therapy of mesenteric-portal system. Treatment of acute portal vein thrombosis has ranged from conservative treatment with thrombolysis and anticoagulation therapy to surgical treatment with thrombectomy and/or intestinal resection.


METHODS
We treated our patient with intraportal infusion of plasminogen activator and then heparin through a percutaneous transhepatic catheter.


RESULTS
Thrombus resolved despite premature interruption of the thrombolytic treatment for neurological complications, which subsequently resolved.


CONCLUSIONS
Conservative management with plasminogen activator, could be considered as a good treatment for patients with acute porto-mesenteric thrombosis.
Guglielmi
Alfredo
A
First Department of General Surgery, University of verona, Borgo Trento Hospital, P.le Stefani 1, 37126 Verona, Italy. alfredo.guglielmi@univr.it
Fior
Francesca
F
Halmos
Orsolya
O
Veraldi
Gian Franco
GF
Rossaro
Lorenzo
L
Ruzzenente
Andrea
A
Cordiano
Claudio
C
D000208:Acute Disease; D000328:Adult; D003093:Colitis, Ulcerative / Q000150:complications*; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D008642:Mesenteric Veins; D010960:Plasminogen Activators / Q000627:therapeutic use; D011169:Portal Vein; D020246:Venous Thrombosis / Q000097:blood* / Q000150:complications* / Q000188:drug therapy
D010960:Plasminogen Activators