[Modification of hyaluronic acid with aromatic amino acids].
Hyaluronic acid was modified with aromatic amino acids (5-aminosalicylic, 4-aminosalicylic, anthranilic, and p-aminobenzoic) in the presence of 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide. The modified glycans contained 9-43% of arylamide groups and 10-33% of isoureidocarbonyl groups depending on the nature of the amino acid. Reduction with sodium borohydride allowed the conversion of isoureidocarbonyl groups into hydroxymethyl groups.
Ponedel'kina
I Iu
IIu
Odinokov
V N
VN
Vakhrusheva
E S
ES
Golikova
M T
MT
Khalilov
L M
LM
Dzhemilov
U M
UM
D024322:Amino Acids, Aromatic / Q000737:chemistry*; D002234:Carbodiimides / Q000737:chemistry*; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry* / Q000302:isolation & purification
D024322:Amino Acids, Aromatic; D002234:Carbodiimides; D006820:Hyaluronic Acid