title: Synthesis of 15R-PGD2: a potential DP2 receptor agonist.
abstract: The first total synthesis of 15R-PGD(2)3 was accomplished. The approach used in this report is also an efficient method to produce 15R-PGE(2). 15R-PGD(2), a potential DP(2) receptor agonist, could be an important novel tool for defining the role of this receptor in inflammatory diseases.
authors.affiliation: Claude Pepper Institute and Department of Chemistry, Florida Institute of Technology, 150 W. University Blvd., Melbourne, FL 32901, USA.
authors.forename: Seongjin
authors.initials: S
authors.lastname: Kim
authors.forename: Sophie
authors.initials: S
authors.lastname: Bellone
authors.forename: Kirk M
authors.initials: KM
authors.lastname: Maxey
authors.forename: William S
authors.initials: WS
authors.lastname: Powell
authors.forename: Gue-Jae
authors.initials: GJ
authors.lastname: Lee
authors.forename: Joshua
authors.initials: J
authors.lastname: Rokach
mesh_terms: D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism*; D007536:Isomerism; D015230:Prostaglandin D2 / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D011971:Receptors, Immunologic / Q000819:agonists* / Q000378:metabolism; D011982:Receptors, Prostaglandin / Q000819:agonists* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin; C470438:15-methylprostaglandin D2; D000242:Cyclic AMP; D015230:Prostaglandin D2; C036293:prostaglandin D2 receptor