title: Use of recombinant activated factor VII for bleeding in pancreatitis: a case series.
abstract: OBJECTIVE
  To describe the effects of recombinant activated factor VII (rFVIIa) in the treatment of bleeding in a series of patients with acute or chronic pancreatitis.
  
  
  METHODS
  Twelve patients (age, 2.5-65 years) with pancreatitis and bleeding were treated with 18.5 to 120 microg/kg of rFVIIa. Eight patients also had sepsis/infection and/or disseminated intravascular coagulation (DIC). The effects of rFVIIa on bleeding, coagulation status, and transfusion requirements were noted.
  
  
  RESULTS
  Bleeding stopped in 4 patients, was markedly reduced in 4 patients, was reduced in 3 patients, and was remained unchanged in 1 patient. For most patients with pre- and post-rFVIIa data, coagulation parameters improved and transfusion requirements reduced. No thrombotic adverse events occurred. Seven patients died for reasons considered to be unrelated to rFVIIa treatment.
  
  
  CONCLUSIONS
  This case series indicates that rFVIIa may be an effective hemostatic treatment of patients with pancreatitis suffering from massive bleeding. There were no thromboembolic events in any patient, including those with sepsis or DIC.
authors.affiliation: Imperial College London, Hammersmith Hospital, London, United Kingdom. m.laffan@imperial.ac.uk
authors.forename: Mike A
authors.initials: MA
authors.lastname: Laffan
authors.forename: R Campbell
authors.initials: RC
authors.lastname: Tait
authors.forename: Jan
authors.initials: J
authors.lastname: Blatný
authors.forename: Kurt
authors.initials: K
authors.lastname: Espersen
authors.forename: Izebelle
authors.initials: I
authors.lastname: Grabowska
authors.forename: Lidia
authors.initials: L
authors.lastname: Loch-Bakoñska
authors.forename: Agata
authors.initials: A
authors.lastname: Pauzkowska
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Stasiak-Pikula
authors.forename: Grazyna
authors.initials: G
authors.lastname: Michalska
authors.forename: Julia
authors.initials: J
authors.lastname: Wendon
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Piotrowska
mesh_terms: D000328:Adult; D000368:Aged; D001777:Blood Coagulation / Q000187:drug effects; D001803:Blood Transfusion; D002675:Child, Preschool; D005167:Factor VII / Q000008:administration & dosage*; D015942:Factor VIIa; D005260:Female; D006470:Hemorrhage / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019283:Pancreatitis, Acute Necrotizing / Q000150:complications*; D050500:Pancreatitis, Chronic / Q000150:complications*; D011994:Recombinant Proteins / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D011994:Recombinant Proteins; D005167:Factor VII; C103587:recombinant FVIIa; D015942:Factor VIIa