title: [A case of vanishing bile duct syndrome associated with hypersensitivity to allopurinol].
abstract: Allopurinol is frequently used for the treatment of hyperuricemia and gout. Sometimes, a life-threatening reaction develops, as is illustrated by the following case report. We describe a 60-year-old male patient who was treated with allopurinol because of asymptomatic hyperuricemia, and he was presented with fever, skin rash, eosinophilia, worsening renal function and vanishing bile duct syndrome. In this report, we discussed vanishing bile duct syndrome as a serious side effect of allopurinol, and we briefly reviewed the etiology, prevention, and treatment modalities for vanishing bile duct syndrome.
authors.affiliation: Department of Internal Medicine, Veterans Hospital, Seoul, Korea.
authors.forename: Seong Ho
authors.initials: SH
authors.lastname: Choi
authors.forename: Soo Hyun
authors.initials: SH
authors.lastname: Yang
authors.forename: Young Bong
authors.initials: YB
authors.lastname: Song
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Yeoung Tae
authors.initials: YT
authors.lastname: Seo
authors.forename: Dong Seog
authors.initials: DS
authors.lastname: Choi
authors.forename: Kyoung Hyoub
authors.initials: KH
authors.lastname: Moon
authors.forename: Jong Hoon
authors.initials: JH
authors.lastname: Byun
authors.forename: Eun Sil
authors.initials: ES
authors.lastname: Yu
mesh_terms: D000493:Allopurinol / Q000009:adverse effects*; D001649:Bile Duct Diseases / Q000209:etiology* / Q000473:pathology; D004342:Drug Hypersensitivity / Q000150:complications*; D006074:Gout Suppressants / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D006074:Gout Suppressants; D000493:Allopurinol