The effect of levetiracetam on essential tremor.
The effect of a single dose of 1,000 mg of levetiracetam on essential tremor was investigated in 24 patients in a double-blind, placebo-controlled trial. There was a significant reduction of hand tremor for at least 2 hours as measured by accelerometry and functional tests.
Bushara
Khalafalla O
KO
Neurology Service (127), Minneapolis Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA. busha001@umn.edu
Malik
Taimur
T
Exconde
Rupert E
RE
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000927:Anticonvulsants / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D020329:Essential Tremor / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006225:Hand / Q000294:innervation / Q000503:physiopathology*; D006801:Humans; D000077287:Levetiracetam; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000503:physiopathology; D009460:Neurologic Examination; D010889:Piracetam / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D010919:Placebos; D020127:Recovery of Function / Q000187:drug effects / Q000502:physiology; D012737:Sex Factors; D013997:Time Factors; D016896:Treatment Outcome
D000927:Anticonvulsants; D010919:Placebos; D000077287:Levetiracetam; D010889:Piracetam