[Experimental study on early escharectomy after major burns in minipigs].
OBJECTIVE
To investigate optimal time for early escharectomy after severe scald in minipigs.


METHODS
Minipigs inflicted with 35% TBSA full thickness burn were employed in the study, and they were randomly divided into A (n = 7, with escharectomy at 6PSH), and B (n = 7, with escharectomy at 24 PSH) groups. The hemodynamics indices, hemorrheology, and the serum levels of cytokines in the two groups were determined before burns and at 6, 8, 16, 24 and 72PSH.


RESULTS
The hemodynamics indices in A group obviously improved compared with those in B group. The cardiac output (CO, 2.28 +/- 0.03 L/min) and right arterial pressure (RAP, 4.54 +/- 0.04 mmHg) in A group recovered to the pre-injury levels at 48 PSH. There was no difference of the hemorrheology indices between the two groups (P > 0.05). The serum contents of cytokines in A group declined to the pre-injury level on 1 PBW, while those in B group were significantly higher than those before injury and those in A group (P < 0.05 or P > 0.01).


CONCLUSIONS
Escharectomy during 6 PBH might be safe and feasible, thus preventing long-term complications effectively.
Xu
Gang
G
Burn Institute, The Worker's Hospital of Tangshan, The Hebei Medical University, Tangshan 063000, P.R. China.
Duan
Chen-Wang
CW
Chen
Shu-Qiang
SQ
Liu
Jun
J
Li
Feng-Shan
FS
Feng
Yu-Zhu
YZ
Liu
Dong-Mei
DM
DU
Xiu-Hong
XH
D000210:Acute-Phase Reaction; D000818:Animals; D016280:Atrial Function, Right; D002056:Burns / Q000503:physiopathology* / Q000601:surgery*; D002302:Cardiac Output; D016207:Cytokines / Q000097:blood; D004195:Disease Models, Animal; D018056:Hemorheology; D013552:Swine; D013556:Swine, Miniature
D016207:Cytokines