title: Anti-estrogenic activity of lignans from Acanthopanax chiisanensis root.
abstract: Anti-estrogenic activity of (-)-sesamin (1), helioxanthin (2), savinin (3), taiwanin C (4), and 3-(3,4-dimethoxybenzyl)-2-(3,4-methylenedioxybenzyl)butyrolactone (5) isolated from the root of Acanthopanax chiisanensis was tested using Ishikawa cells. Among them, compound 3 exhibited anti-estrogenic activity (IC50 = 4.86 microM).
authors.affiliation: College of Pharmacy, Seoul National University, Seoul 151-742, Korea. jnp@korea.com
authors.forename: Sanghyun
authors.initials: S
authors.lastname: Lee
authors.forename: Hye Hyun
authors.initials: HH
authors.lastname: Yoo
authors.forename: Xiang Lan
authors.initials: XL
authors.lastname: Piao
authors.forename: Ju Sun
authors.initials: JS
authors.lastname: Kim
authors.forename: Sam Sik
authors.initials: SS
authors.lastname: Kang
authors.forename: Kuk Hyun
authors.initials: KH
authors.lastname: Shin
mesh_terms: D000251:Adenosine Triphosphatases / Q000096:biosynthesis; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D028001:Eleutherococcus / Q000737:chemistry*; D004790:Enzyme Induction / Q000187:drug effects; D004965:Estrogen Antagonists / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D006801:Humans; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D048789:Phytoestrogens / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013778:Tetrazolium Salts; D013844:Thiazoles
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004965:Estrogen Antagonists; D017705:Lignans; D048789:Phytoestrogens; D013778:Tetrazolium Salts; D013844:Thiazoles; D000251:Adenosine Triphosphatases; C022616:thiazolyl blue