title: Synthetic studies on cyclic octapeptides: Yunnanin F and Hymenistatin.
abstract: Two biologically active cyclic peptides, Yunnanin F 8 and Hymenistatin 16 were synthesized and the structures were established on the basis of analytical, IR, NMR and mass spectral data. The newly synthesized compounds were screened for their antimicrobial and pharmacological activities. These cyclic octapeptides have shown moderate to good growth inhibition against bacterial strains and weak activity against fungal strains more than that of the standard drug against only Pseudomonas aeruginosa but weak to moderate activity against remaining three bacterial strains. They have shown very weak activity against fungal strains. Yunnanin F possessed good anthelmintic activity while Hymenistatin possessed very low activity, but both showed moderate anti-inflammatory activity.
authors.affiliation: Department of Post-Graduate Studies and Research in Chemistry, Mangalore University, Mangalagangotri 574 199, Mangalore, India. bojapoojary@yahoo.com
authors.forename: Boja
authors.initials: B
authors.lastname: Poojary
authors.forename: Shiddappa L
authors.initials: SL
authors.lastname: Belagali
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D004487:Edema / Q000188:drug therapy / Q000473:pathology; D008826:Microbial Sensitivity Tests; D009835:Oligochaeta / Q000187:drug effects; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
chemical_list: D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D010456:Peptides, Cyclic; C502764:hymenistatin; C502765:yunnanin F