title: Synthetic wogonin derivatives suppress lipopolysaccharide-induced nitric oxide production and hydrogen peroxide-induced cytotoxicity.
abstract: Wogonin (5,7-dihydroxy-8-methoxyflavone) has been reported to exhibit a variety of biological properties including anti-inflammatory and neuroprotective functions. In this study, biological activities of diverse synthetic wogonin derivatives have been evaluated in two experimental cell culture models. Inhibitory activities of wogonin derivatives on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV2 microglial cells and on hydrogen peroxide (H2O2)-induced neuronal cell death in SH-SY5Y human neuroblastoma were examined. Wogonin derivatives such as WS2 and WS3 showed more potent suppressive activities on LPS-induced NO production and H2O2-induced cytotoxicity than wogonin itself. In addition, thiol substitution played a minor role in enhancing the activities of the derivatives. These findings may contribute to the development of novel anti-inflammatory and neuroprotective agents derived from wogonin.
authors.affiliation: Department of Pharmacology, Kangwon National University, Chuncheon 200-701, Korea.
authors.forename: Wanjoo
authors.initials: W
authors.lastname: Chun
authors.forename: Hee Jae
authors.initials: HJ
authors.lastname: Lee
authors.forename: Pil-Jae
authors.initials: PJ
authors.lastname: Kong
authors.forename: Gun Hee
authors.initials: GH
authors.lastname: Lee
authors.forename: Il-Young
authors.initials: IY
authors.lastname: Cheong
authors.forename: Haeil
authors.initials: H
authors.lastname: Park
authors.forename: Sung-Soo
authors.initials: SS
authors.lastname: Kim
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D044950:Flavanones / Q000737:chemistry / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D006861:Hydrogen Peroxide / Q000037:antagonists & inhibitors* / Q000633:toxicity; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D051379:Mice; D017628:Microglia / Q000187:drug effects / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis*; D016877:Oxidants / Q000633:toxicity; D018384:Oxidative Stress / Q000187:drug effects; D014407:Tumor Cells, Cultured
chemical_list: D044950:Flavanones; D016166:Free Radical Scavengers; D008070:Lipopolysaccharides; D016877:Oxidants; D009569:Nitric Oxide; D006861:Hydrogen Peroxide; C085514:wogonin