title: DPPH radical-scavenging effect of several phenylpropanoid compounds and their glycoside derivatives.
abstract: Eugenol, isoeugenol, caffeic acid, ferulic acid, isoferulic acid, estragole, trans-anethole, and paeonol are components of a Chinese herbal medicine used as a painkiller and stomachic. We investigated the potential role of these compounds as antioxidants. We studied the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical-scavenging effect of these molecules, together with some glycoside derivatives, to ascertain their potential in reducing the levels of activated oxygen species in vivo. The DPPH radical-scavenging effects of eugenol, isoeugenol, and the glycoside derivatives of caffeic acid, ferulic acid, and isoferulic acid (SC(50)=8-28 microM) were similar to those of alpha-tocopherol, which was used as a positive control.
authors.affiliation: Department of Biotechnology and Chemistry, School of Engineering, Kinki University, Higashihiroshima city 739-2116, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Tominaga
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Goto
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kasemura
authors.forename: Masato
authors.initials: M
authors.lastname: Nomura
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D001713:Biphenyl Compounds; D002109:Caffeic Acids / Q000494:pharmacology; D002934:Cinnamates / Q000494:pharmacology; D003373:Coumaric Acids / Q000494:pharmacology; D005054:Eugenol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D006027:Glycosides / Q000494:pharmacology*; D010851:Picrates / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D002109:Caffeic Acids; D002934:Cinnamates; D003373:Coumaric Acids; D016166:Free Radical Scavengers; D006027:Glycosides; D010851:Picrates; D017382:Reactive Oxygen Species; D005054:Eugenol; C036643:isoeugenol; C004999:ferulic acid; C004931:1,1-diphenyl-2-picrylhydrazyl; C040048:caffeic acid; C008180:isoferulic acid