Dominicin, a cyclic octapeptide, and laughine, a bromopyrrole alkaloid, isolated from the Caribbean marine sponge Eurypon laughlini.
Dominicin, a new cyclic peptide, and the new bromopyrrole alkaloid laughine (4) have been isolated from the marine sponge Eurypon laughlini collected in Dominica. The structures of 1 and 4 were determined by a combination of spectroscopic analysis and chemical degradation. Single-crystal X-ray diffraction analysis confirmed the structure of dominicin (1).
Williams
David E
DE
Department of Chemistry, University of British Columbia, Vancouver, B.C., Canada, V6T 1Z1.
Patrick
Brian O
BO
Behrisch
Hans W
HW
Van Soest
Rob
R
Roberge
Michel
M
Andersen
Raymond J
RJ
D000470:Alkaloids; D000818:Animals; D018360:Crystallography, X-Ray; D019424:Dominica; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification*; D011161:Porifera / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification*
D000470:Alkaloids; D010456:Peptides, Cyclic; D011758:Pyrroles; C499562:dominicin; C499563:laughine