Urinary 8-hydroxydeoxyguanosine levels as a biomarker for progression of Parkinson disease.
8-hydroxydeoxyguanosine (8-OHdG) has been used to evaluate oxidative stress. The authors investigated urinary 8-OHdG levels in 72 patients with Parkinson disease (PD) and in normal and disease control groups. The mean urinary 8-OHdG increased with the stage of PD and was not influenced by the current dose of DOPA. Our results suggest that urinary 8-OHdG is a potentially useful biomarker for evaluating the progression of PD.
Sato
Shigeto
S
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Mizuno
Yoshikuni
Y
Hattori
Nobutaka
N
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000652:urine; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D003404:Creatinine / Q000652:urine; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D004295:Dihydroxyphenylalanine / Q000008:administration & dosage; D018450:Disease Progression; D015259:Dopamine Agents / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D010300:Parkinson Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000652:urine*; D011237:Predictive Value of Tests
D015415:Biomarkers; D015259:Dopamine Agents; D004295:Dihydroxyphenylalanine; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003404:Creatinine; D003849:Deoxyguanosine