Anti-GBM and anti-MPO antibodies coexist in a case of pulmonary renal syndrome.
The case of a 12-year-old boy with pulmonary renal syndrome is described. Antimyeloperoxidase (anti-MPO) and antiglomerular basement membrane (anti-GBM) antibodies were positive. The clinical course and immunosuppressive therapy are discussed. Pulmonary renal syndrome is a rare event in childhood and coexistence of the two types of antibodies is exceptional.
Hijosa
Marta Melgosa
MM
Pediatric Nephrology Unit, Hospital La Paz, Madrid, Spain. mmelgosa.hulp@salud.madrid.org
Román
Laura Espinosa
LE
Camblor
Carlota Fernández
CF
García
María Luz Picazo
ML
Salcedo
Dorotea Pascual
DP
Torres
Mercedes Navarro
MN
D000906:Antibodies / Q000097:blood*; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000276:immunology* / Q000628:therapy; D002648:Child; D005921:Glomerulonephritis / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D006470:Hemorrhage / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D007165:Immunosuppression Therapy; D008171:Lung Diseases / Q000276:immunology*; D008297:Male; D009195:Peroxidase / Q000276:immunology*; D013577:Syndrome
D000906:Antibodies; D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D007074:Immunoglobulin G; C051951:antiglomerular basement membrane antibody; D009195:Peroxidase