[Immunogenetic HLA markers of chronic viral hepatitis].
OBJECTIVE
To study possible immunogenetic HLA markers of chronic viral hepatitides.


METHODS
Using the reaction of complement-dependent cytotoxicity by Terasaki, we analysed distribution of leukocytic HLA antigens (loci A, B and C) in 179 patients with chronic viral hepatitides B, C and D in Russians and Kazakhs living in the Astrakhan Region.


RESULTS
In the Russian population we discovered a significant positive association of CVHB with HLA-B18, HLA-B35, HLA-B40, HLA-Cw3 antigens, and negative one--with HLA-A2. In Kazakhs with CVHB there was a positive association with HLA-A3, HLA-B18 and negative one--with HLA-A11. Alleles HLA-A10, HLA-B35, HLA-B40 and HLA-Cw3 mark CVHC in Russians. HLA-Cw4 specificity acts as protector in development of chronic HCV-infection. A correlation was found between carriage of some specificities and haplotypes of HLA and activity of chronic HBV and HCV infection. A high risk of chronic delta infection in Russians is associated with HLA-B8 and HLA-B35, in Kazakhs--with HLA-B35 and HLA-D40. There are significant associations between CVHB, CVHC, chronic delta infection and some HLA haplotypes.


CONCLUSIONS
A universal role of HLA-B35 specificity in development of CVH irrespective of hepatotropic virus and patients' nationality is shown.
Popov
E A
EA
Levitan
B N
BN
Alekseev
L P
LP
Pronina
O A
OA
Suchkov
S V
SV
D002908:Chronic Disease; D006680:HLA Antigens / Q000276:immunology*; D015236:HLA-C Antigens / Q000276:immunology; D006506:Hepatitis A / Q000208:ethnology / Q000276:immunology; D006509:Hepatitis B / Q000208:ethnology / Q000276:immunology; D006526:Hepatitis C / Q000208:ethnology / Q000276:immunology; D003699:Hepatitis D / Q000208:ethnology / Q000276:immunology; D006525:Hepatitis, Viral, Human / Q000208:ethnology* / Q000276:immunology*; D006801:Humans; D007623:Kazakhstan; D012426:Russia
D006680:HLA Antigens; D015236:HLA-C Antigens; C039966:HLA-C*04 antigen