[Study on preparation of the inclusion compound of curcumin with beta-cyclodextrin].
OBJECTIVE
The inclusion compound of curcumin with, beta-CD was preparated to increase the solubility and bioavaliability of curcumin.


METHODS
Prepare inclusion compound was studied with orthogonal design. The inclusion compound was verified with fluorometry, TLC, and phase solubility.


RESULTS
The best way to prepare inclusion compound are as follows: the molar ratio between curcumin and, beta-CD is 1:1, temperture is 40 degrees C, reaction time is 2 h.


CONCLUSIONS
Solubility of inclusion compound is 10 times than curcumin.
Han
Gang
G
Pharmaceutical Department, North China Coal Mine Medical College, Tangshan.
Xu
Jianhua
J
Li
Weina
W
Ning
Chunling
C
D001682:Biological Availability; D002855:Chromatography, Thin Layer; D003474:Curcumin / Q000737:chemistry*; D004337:Drug Carriers; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000737:chemistry*; D000431:Ethanol; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013678:Technology, Pharmaceutical / Q000379:methods*; D013696:Temperature; D013997:Time Factors; D047392:beta-Cyclodextrins / Q000737:chemistry*
D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D047392:beta-Cyclodextrins; D000431:Ethanol; D003474:Curcumin