Food-drug interaction between ferulic acid and nateglinide involving the fluorescein/H+ cotransport system.
In clinical, patients usually take many kinds of drugs at the same time. Thus, drug-drug interactions involving transporters can often directly affect the therapeutic safety and efficacy of many drugs. However, there have been few studies on food-drug interactions involving transporters. Dietary polyphenols have been widely assumed to be beneficial to human health. Polyphenols are commercially prepared and used as functional foods. We report here for the first time that ferulic acid, which is widely used as a functional food, affects the transport of clinical agents. It is important to be aware of the potential of food-drug interactions and to act in order to prevent undesirable and harmful clinical consequences.
Itagaki
Shirou
S
Department of Clinical Pharmaceutics and Therapeutics, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12-jo, Nishi 6-chome, Kita-ku, Sapporo 060-0812, Japan.
Kobayashi
Yoko
Y
Otsuka
Yukio
Y
Kubo
Sayaka
S
Kobayashi
Masaki
M
Hirano
Takeshi
T
Iseki
Ken
K
D018938:Caco-2 Cells; D003373:Coumaric Acids / Q000378:metabolism* / Q000494:pharmacology; D003510:Cyclohexanes / Q000378:metabolism* / Q000494:pharmacology; D004347:Drug Interactions; D019793:Fluorescein / Q000378:metabolism*; D005502:Food; D006801:Humans; D007004:Hypoglycemic Agents; D007413:Intestinal Mucosa / Q000378:metabolism; D027501:Monocarboxylic Acid Transporters / Q000187:drug effects / Q000378:metabolism*; D000077715:Nateglinide; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology
D003373:Coumaric Acids; D003510:Cyclohexanes; D007004:Hypoglycemic Agents; D027501:Monocarboxylic Acid Transporters; D000077715:Nateglinide; D010649:Phenylalanine; C004999:ferulic acid; D019793:Fluorescein