[Parvovirus B9 infection in a renal transplant recipient. Diagnosis by detection of viral genome in peripheral blood].
Parvovirus B19 can produce a picture known as pure red blood aplasia in recipients of solid organ. Occasionally the viruses cause decrease of the other blood cells, and various extra-hematologic manifestations. Common diagnosis is realised by bone marrow examination. The diagnostic value of the viral genome in the blood stream is not well defined. We reported the case of a male of 17 years of age, whose diagnosis was done by repeated determinations of the viral parvovirus B19 genome in peripheral blood. It was confirmed by a biopsy of the iliac crest. The patient was treated with unspecific IgG immunoglobulins, with complete recovery from the symptoms and signs. It did not have any recurrence of the disease. This case suggests that the realisation of PCR of Parvovirus B19 in renal transplant patients with pure red cell aplasia could be of greater interest in the diagnosis and monitoring of the disease. The detection of the viral genome could avoid the administration of unnecessary blood transfusions, and possibly the realization of bone marrow biopsy.
Gómez Huertas
E
E
Servicio de Nefrología, Hospital Central de Asturias, 33006 Oviedo, España. ernesto.gomez@sespa.princast.es
Melón
S
S
Laurés
A S
AS
de Oña
M
M
Alvarez-Grande
J
J
D000293:Adolescent; D004279:DNA, Viral / Q000097:blood*; D016679:Genome, Viral; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D010322:Parvoviridae Infections / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D016732:Parvovirus B19, Human / Q000235:genetics
D004279:DNA, Viral