[Effect of opiod peptides on free radical oxidation in a bone regenerate after fracture].
Opioid peptides (DSLET and DAGO) stimulating bone tissue regeneration were studied for effects on content of free radical products in regenerate tissue from the region of leg fracture in mice at various terms of reparative osteogenesis. These opioids reduce concentration of malonic dialdehyde and dienic conjugastes in bone for 10 days after fracture.
Liashev
Iu D
IuD
Kniazev
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AI
Solin
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AV
D000818:Animals; D002146:Bony Callus / Q000187:drug effects* / Q000378:metabolism; D004195:Disease Models, Animal; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / Q000627:therapeutic use; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D017102:Fracture Healing / Q000187:drug effects; D050723:Fractures, Bone / Q000378:metabolism*; D005609:Free Radicals / Q000378:metabolism*; D007867:Leg Bones / Q000187:drug effects* / Q000378:metabolism; D035002:Lower Extremity / Q000293:injuries*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D018847:Opioid Peptides / Q000627:therapeutic use*; D010084:Oxidation-Reduction
D005609:Free Radicals; D018847:Opioid Peptides; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D004743:Enkephalin, Leucine; C034318:enkephalin, Ser(2), Leu(5), Thr(6)-