Solid-supported reagents and catalysts for the preparation of large ring compounds.
Parallel combinatorial synthesis in solution using immobilized reagents, catalysts, and scavengers has emerged as a powerful technique for the preparation of diverse libraries of compounds. This technique has only recently been applied to the synthesis of large-ring compounds. In this comprehensive review several strategies are presented and discussed, including Pd-catalyzed allylic alkylation, Stille-coupling, macrolactonization and macrolactamization using solid supported reagents and catalysts. In several cases site isolation has allowed operation, of these macrocyclization reactions in concentrated solution (pseudo-dilution effect).
Gonthier
Elisabeth
E
Fachbereich Chemie, University Dortmund, Dortmund, Germany.
Breinbauer
Rolf
R
D002384:Catalysis; D006573:Heterocyclic Compounds, 1-Ring / Q000138:chemical synthesis* / Q000737:chemistry*; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation
D006573:Heterocyclic Compounds, 1-Ring; D007202:Indicators and Reagents