[Oxidative stress in mechanism of psychosomatic disorders realization in duodenal ulcer in students].
OBJECTIVE
To study the role of oxidative stress in mechanism of psychosomatic disorders involvement in pathogenesis of ulcerogenesis.


METHODS
Psychosomatic disorders (PSD) and oxidative stress (OS) were assessed in 120 students with duodenal ulcer (DU) who had no concomitant pathology. Examination for PSD included interviewing by questionnaires. OS was judged by the level of lipid peroxidation products (malonic dialdehyde and dienic conjugates) and antioxidant activity--by glutathion peroxidase and superoxidedismutase. Melatonin was measured by enzyme immunoassay.


RESULTS
A close correlation was discovered between the severity and features of PSD, lowering of melatonin, severity of OS and clinical features of the disease.


CONCLUSIONS
DU students develop PSD which become leading factors of ulcerogenesis. One of the mechanisms of their participation in ulcerogenesis may be related with lowering of melatonin which is a potent stress regulator and corrector of lipid peroxidation and antioxidant activity.
Oparin
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D000293:Adolescent; D000328:Adult; D004381:Duodenal Ulcer / Q000201:enzymology / Q000453:epidemiology* / Q000503:physiopathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D011602:Psychophysiologic Disorders / Q000201:enzymology / Q000453:epidemiology* / Q000503:physiopathology*; D012720:Severity of Illness Index; D013334:Students / Q000523:psychology* / Q000706:statistics & numerical data*; D013482:Superoxide Dismutase / Q000378:metabolism; D011795:Surveys and Questionnaires
D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase