Chemistry-to-gene screens in Caenorhabditis elegans.
The nematode worm Caenorhabditis elegans is a genetic model organism linked to an impressive portfolio of fundamental discoveries in biology. This free-living nematode, which can be easily and inexpensively grown in the laboratory, is also a natural vehicle for screening for drugs that are active against nematode parasites. Here, we show that chemistry-to-gene screens using this animal model can define targets of antiparasitic drugs, identify novel candidate drug targets and contribute to the discovery of new drugs for treating human diseases.
Jones
Andrew K
AK
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK.
Buckingham
Steven D
SD
Sattelle
David B
DB
D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology*; D017173:Caenorhabditis elegans / Q000737:chemistry / Q000235:genetics / Q000254:growth & development; D015195:Drug Design; D004351:Drug Resistance / Q000235:genetics; D017238:Genes, Helminth / Q000235:genetics*; D023421:Models, Animal
D000969:Antinematodal Agents