[Current understanding of primary biliary cirrhosis].
OBJECTIVE
To examine characteristics of the course of primary biliary cirrhosis (PBC).


METHODS
The study of 150 PBC patients aged 26-82 years used clinical, biochemical, immunological and morphological methods.


RESULTS
Antimitochondrial antibodies of type M2 (AMAM2) were detected in 85.4% patients with PBC. A positive correlation was found between clinicobiochemical activity of the disease and number of AMAM2. AMAM2-positive patients more frequently had extrahepatic manifestations, overlap syndrome, higher biochemical and immunological activity vs AMAM2-negative patients.


CONCLUSIONS
The following variants of PBC course were identified: classic AMAM2-positive, AMAM2-negative, overlapping of PBC and autoimmune hepatitis. Concentration of AMAM2 has diagnostic and prognostic value in PBC.
Il'ichenko
L Iu
LIu
Golovanova
E V
EV
Tsaregorodtseva
T M
TM
Serova
T I
TI
Gudkova
R B
RB
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology*; D008099:Liver / Q000503:physiopathology; D008105:Liver Cirrhosis, Biliary / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D008931:Mitochondria, Muscle / Q000276:immunology
D000906:Antibodies; D001323:Autoantibodies; D007136:Immunoglobulins