Protocol for mitomycin C use in glaucoma surgery.
OBJECTIVE
To evaluate the results of a protocol described for mitomycin C (MMC) use in trabeculectomy or combined surgery (phacoemulsification and trabeculectomy).


METHODS
A total of 143 eyes (60 trabeculectomies and 83 combined surgeries) of 124 patients were divided into four groups: group 1 (without MMC); group 2 (with 0.1 mg/ml MMC); group 3 (with 0.2 mg/ml MMC), and group 4 (with 0.4 mg/ml MMC). Two-minute MMC was used in every case in groups 2, 3 and 4. The results were analysed after 1 year of follow-up. Intraocular pressure (IOP) and complications were evaluated. Successful IOP control was defined when IOP was <21 mmHg and <16 mmHg if advanced glaucoma was present, always without additional medical treatment.


RESULTS
Mean preoperative IOP decreased from 24.60 mmHg (SD 1.40 mmHg) to 13.47 mmHg (SD 0.37 mmHg) (p < 0.00001), 12 months postoperatively. Control in IOP was achieved in 79.02% of eyes. No significant differences were found in final mean IOP values (p > 0.196) or in postoperative complications (p > 0.120) in groups 2, 3 and 4.


CONCLUSIONS
With the protocol described, a selection of concentration of MMC has been made in different clinical forms of glaucoma. No significant differences in IOP control and postoperative complications were noticed among the groups.
Maquet
J A
JA
Department of Ophthalmology, University Hospital, University of Valladolid, Valladolid, Spain. maquet@teleline.es
Dios
E
E
Aragón
J
J
Bailez
C
C
Ussa
F
F
Laguna
N
N
D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000627:therapeutic use; D002985:Clinical Protocols; D003228:Conjunctiva / Q000601:surgery; D005260:Female; D005901:Glaucoma / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage* / Q000627:therapeutic use; D018918:Phacoemulsification; D017410:Practice Guidelines as Topic; D011446:Prospective Studies; D012590:Sclera / Q000187:drug effects / Q000601:surgery; D013524:Surgical Flaps; D013997:Time Factors; D014130:Trabeculectomy
D000903:Antibiotics, Antineoplastic; D016685:Mitomycin