title: Design and synthesis of novel antidiabetic agents.
abstract: The synthesis and structure-activity relationships of a novel series of substituted quercetins that activates peroxisome proliferator-activated receptor gamma (PPARgamma) are reported. The PPARgamma agonistic activity of the most potent compound in this series is comparable to that of the thiazolidinedione-based antidiabetic drugs currently in clinical use.
authors.affiliation: College of Pharmacy & Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, Korea.
authors.forename: Joon Yeol
authors.initials: JY
authors.lastname: Lee
authors.forename: Won-Hui
authors.initials: WH
authors.lastname: Park
authors.forename: Min-Kyoung
authors.initials: MK
authors.lastname: Cho
authors.forename: Hyun Jin
authors.initials: HJ
authors.lastname: Yun
authors.forename: Byung-Ho
authors.initials: BH
authors.lastname: Chung
authors.forename: Youngmi Kim
authors.initials: YK
authors.lastname: Pak
authors.forename: Hoh-Gyu
authors.initials: HG
authors.lastname: Hahn
authors.forename: Seung Hoon
authors.initials: SH
authors.lastname: Cheon
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D018076:DNA, Complementary / Q000096:biosynthesis / Q000235:genetics; D015195:Drug Design; D005347:Fibroblasts / Q000378:metabolism; D005822:Genetic Vectors; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D047495:PPAR gamma / Q000235:genetics; D010957:Plasmids; D011794:Quercetin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D014162:Transfection
chemical_list: D018076:DNA, Complementary; D007004:Hypoglycemic Agents; D007202:Indicators and Reagents; D047495:PPAR gamma; D011794:Quercetin