title: The role of mitochondrial DNA in the development of type 2 diabetes caused by fetal malnutrition.
abstract: Epidemiological studies have revealed strong and reproducible links between indices of poor fetal growth and susceptibility to the development of glucose intolerance and insulin resistance syndrome in adult life. To explain these associations, the thrifty phenotype hypothesis has been proposed. Mitochondrial DNA abnormalities have been known to cause insulin deficiency, insulin resistance and diabetes mellitus. In this review, we propose that mitochondrial dysfunction is a link between malnutrition during early life and disease in adult life. The potential mechanism for mitochondrial dysfunction will be focused on availability of the taurine and nucleotides, and imprinting on the genes.
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-744, South Korea.
authors.forename: Yun Yong
authors.initials: YY
authors.lastname: Lee
authors.forename: Kyong Soo
authors.initials: KS
authors.lastname: Park
authors.forename: Youngmi Kim
authors.initials: YK
authors.lastname: Pak
authors.forename: Hong Kyu
authors.initials: HK
authors.lastname: Lee
mesh_terms: D001483:Base Sequence; D004272:DNA, Mitochondrial / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics; D044342:Malnutrition / Q000196:embryology*; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012357:RNA, Transfer, Lys / Q000235:genetics
chemical_list: D004272:DNA, Mitochondrial; D012357:RNA, Transfer, Lys