title: Link between monthly rates of four subtypes of acute myocardial infarction and their corresponding cosmophysical activity parameters.
abstract: The aim of this study was (1) to examine the relation between the monthly rate of acute myocardial infarction (AMI) and three cosmophysical activity parameters: solar activity (SA), geomagnetic activity (GMA), and cosmic rays activity (CRA) levels; (2) to study whether different subtypes of AMI: ST-elevation MI (STEMI), non-ST-elevation (NSTEMI), Q-wave (Q-waveMI) and non-Q-wave (NQ-wave MI) are linked with monthly cosmophysical indices or with the daily level (I degrees-IV degrees) of GMA.
  
  
  METHODS
  For the first question, we studied for 204 consecutive months (1983-1999) 16,683 patients (including 10405 males) with AMI who were included in the Kaunas Registry and for the second, 3824 AMI patients (2342 males), 72-month data. Cosmophysical data were obtained from the Apatity Neutron Monitoring Station of the Russian Academy of Science.
  
  
  RESULTS
  According to neutron monitoring data, total AMI and all its subtypes significantly correlated with monthly levels of CRA and inversely correlated with SA and GMA indices (r = 0.32-0.45; p = 0.0007-0.0001). No significant correlation was found between AMI subtypes and the daily level (I degrees-IV degrees) of GMA. All cosmophysical parameters were stronger in female patients.
  
  
  CONCLUSIONS
  The monthly rates of all subtypes of AMI were significantly correlated with CRA and inversely correlated with SA and GMA, more strongly in female patients. We presume that the environmental factors studied here affect the general patho-physiological components of AMI, and that different subtypes are a consequence of the localization and extent of the process.
authors.affiliation: Division of Cardiology and Epidemiology Unit, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel. stoupel@inter.net.il
authors.forename: Eliyah
authors.initials: E
authors.lastname: Stoupel
authors.forename: Stase
authors.initials: S
authors.lastname: Domarkiene
authors.forename: Richardas
authors.initials: R
authors.lastname: Radishauskas
authors.forename: Gailute
authors.initials: G
authors.lastname: Bernotiene
authors.forename: Evgeny
authors.initials: E
authors.lastname: Abramson
authors.forename: Peter
authors.initials: P
authors.lastname: Israelevich
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Sulkes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003359:Cosmic Radiation; D004574:Electromagnetic Fields; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000145:classification* / Q000453:epidemiology*; D010507:Periodicity; D012727:Sex Characteristics; D019445:Solar Activity