On the potential use of flavonoids in the treatment and prevention of pancreatic cancer.
Pancreatic cancer is a disease carrying a dismal prognosis, with overall 5-year survival at around 4%. Recent clinical trials of adjuvant therapies have not found a dramatic increase in median survival. In the current review, we examine the available literature on flavonoids, a group of naturally occurring substances, for their effects on cancer cells and potential for therapy of pancreatic cancer in the future. With the available in vitro and in vivo data, it is likely that flavonoids will move into the clinical arena as therapeutic or preventive tools for cancer.
Roginsky
Alexandra B
AB
Northwestern University Feinberg School of Medicine, Department of Surgery, Chicago, IL 60611, USA.
Ujiki
Michael B
MB
Ding
Xian-Zhong
XZ
Adrian
Thomas E
TE
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D005419:Flavonoids / Q000627:therapeutic use*; D006801:Humans; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000517:prevention & control*
D000970:Antineoplastic Agents; D005419:Flavonoids