Biosynthesis of the marine antibiotic pentabromopseudilin. 2. The pyrrole ring.
The biosynthesis of the potent marine antibiotic, pentabromopseudilin (1), was investigated. Feeding studies with Alteromonas luteoviolaceus were performed on a defined medium. D,L-[5-(13)C]proline was incorporated symmetrically, demonstrating that the pyrrole ring of pentabromopseudilin is derived from proline.
Peschke
Jörg D
JD
Institut für Organische und Biomolekulare Chemie der Georg-August-Universität, Göttingen, Germany.
Hanefeld
Ulf
U
Laatsch
Hartmut
H
D020591:Alteromonas / Q000187:drug effects* / Q000254:growth & development; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D011758:Pyrroles; C094409:pentabromopseudilin