title: TSH receptor protein is selectively expressed in normal human extraocular muscle.
abstract: Thyroid-associated ophthalmopathy is a common manifestation of Graves' disease. Its pathophysiology is not well understood but an antigen shared between the thyroid and orbit is thought to play a role. Using immunohistochemistry, we have demonstrated the presence of the autoantigenic target of Graves' disease, the thyroid-stimulating hormone receptor, in normal human extraocular muscle. These results support previous findings of the full length and splice variant thyroid-stimulating hormone receptor cDNA in extraocular muscle. The observation of the autoimmune target--the thyroid-stimulating hormone receptor protein--being shared between the thyroid and extraocular muscle lends greater support to the notion that an extraocular muscle thyroid-stimulating hormone receptor is also a likely target autoantigen in thyroid-associated ophthalmopathy.
authors.affiliation: Clinical Pharmacology and Therapeutics Unit, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria 3084, Australia.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Kloprogge
authors.forename: Bridget E
authors.initials: BE
authors.lastname: Busuttil
authors.forename: Albert G
authors.initials: AG
authors.lastname: Frauman
mesh_terms: D000906:Antibodies; D001324:Autoantigens / Q000378:metabolism; D006111:Graves Disease / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D009801:Oculomotor Muscles / Q000378:metabolism*; D011989:Receptors, Thyrotropin / Q000276:immunology / Q000378:metabolism*; D013961:Thyroid Gland / Q000378:metabolism
chemical_list: D000906:Antibodies; D001324:Autoantigens; D011989:Receptors, Thyrotropin