title: Early selection of a new UL97 mutant with a severe defect of ganciclovir phosphorylation after valaciclovir prophylaxis and short-term ganciclovir therapy in a renal transplant recipient.
abstract: We describe the emergence of a new ganciclovir resistance mutation in the UL97 gene of human cytomegalovirus, deletion of codon 601, after valaciclovir and short-term ganciclovir therapy following kidney transplantation. Its role in ganciclovir resistance was supported by decreased ganciclovir phosphorylation in a recombinant vaccinia virus system.
authors.affiliation: Department of Bacteriology-Virology-Hygiene, EA 3175, Teaching Hospital Dupuytren, Limoges cedex, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Hantz
authors.forename: Detlef
authors.initials: D
authors.lastname: Michel
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Fillet
authors.forename: Vincent
authors.initials: V
authors.lastname: Guigonis
authors.forename: Gaël
authors.initials: G
authors.lastname: Champier
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Mazeron
authors.forename: Albert
authors.initials: A
authors.lastname: Bensman
authors.forename: François
authors.initials: F
authors.lastname: Denis
authors.forename: Thomas
authors.initials: T
authors.lastname: Mertens
authors.forename: Axelle
authors.initials: A
authors.lastname: Dehee
authors.forename: Sophie
authors.initials: S
authors.lastname: Alain
mesh_terms: D000212:Acyclovir / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000293:Adolescent; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D018890:Chemoprevention; D003062:Codon; D003587:Cytomegalovirus / Q000187:drug effects* / Q000235:genetics; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000821:virology; D024882:Drug Resistance, Viral / Q000235:genetics*; D015774:Ganciclovir / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008969:Molecular Sequence Data; D010766:Phosphorylation; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000235:genetics*; D017384:Sequence Deletion; D000077483:Valacyclovir; D014633:Valine / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D003062:Codon; D017853:Phosphotransferases (Alcohol Group Acceptor); C075365:ganciclovir kinase; D014633:Valine; D000077483:Valacyclovir; D015774:Ganciclovir; D000212:Acyclovir