title: [Enhancement of thrombolytic activities of Carthamus tinctorius processed with fermentation with a bacillus sp. C2-13].
abstract: A processing method to enhance thrombolytic effect of Carthamus tinctorius using a fermentation technology with bacillus sp. C2-13 was investigated. The fibrinolysis and anticoagulation activity of thrombolytic extracts from an optimized fermentation process was studied using a carrageenan induced mice model. The fermented extracts resulted in significantly better thrombolytic activity, suggesting that the process was promising for use in the study and preparation of nature medicines.
authors.affiliation: College of Life Science, Sichuan University, Chengdu 610064, China.
authors.forename: Chen
authors.initials: C
authors.lastname: He
authors.lastname: Jin-Zhao
authors.forename: Zhi-hua
authors.initials: ZH
authors.lastname: Feng
authors.forename: Jia-feng
authors.initials: JF
authors.lastname: Bai
authors.forename: Tian-li
authors.initials: TL
authors.lastname: Tian
authors.forename: Xing-yu
authors.initials: XY
authors.lastname: Zhang
authors.forename: Qi-ling
authors.initials: QL
authors.lastname: Sun
mesh_terms: D000818:Animals; D001407:Bacillus; D031187:Carthamus tinctorius / Q000737:chemistry* / Q000382:microbiology; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D005285:Fermentation; D005342:Fibrinolysis / Q000187:drug effects*; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D051381:Rats; D017207:Rats, Sprague-Dawley; D013918:Thrombin Time
chemical_list: D004365:Drugs, Chinese Herbal; D005343:Fibrinolytic Agents