Synthesis of novel N-substituted imidazolecarboxylic acid hydrazides as monoamine oxidase inhibitors.
Novel 2-alkylsulfanyl-1-benzyl-5-imidazolecarboxylic acid hydrazides (15a,b) were synthesized as analogues of isocarboxazide, which is a known nonselective irreversible monoamine oxidase inhibitor and tested for monoamine oxidase A and B inhibitory activity. Neither of the compounds showed any inhibition of MAO B activity up to a high concentration of 100 microM. An MAO A activity was only slowly inhibited at this high concentration after prolonged incubation with either compound. This suggests any observed inhibition is not very specific.
Hadizadeh
Farzin
F
Pharmacy Faculty, Mashhad University of Medical Sciences, Mashhad, Iran. fhadizadeh@yahoo.com <fhadizadeh@yahoo.com>
Ghodsi
Razieh
R
D006801:Humans; D006834:Hydrazines / Q000138:chemical synthesis* / Q000494:pharmacology; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007520:Isocarboxazid / Q000737:chemistry; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D006834:Hydrazines; D007093:Imidazoles; D008996:Monoamine Oxidase Inhibitors; D007520:Isocarboxazid; D008995:Monoamine Oxidase