Polyamines: metabolism and implications in human diseases.
Classically, polyamines is a family of molecules (i.e. putrescine, spermine, spermidine) derived from ornithine according to a decarboxylation/condensative process. More recently, it has been demonstrated that arginine can be metabolised according to the same pathway leading to agmatine formation. Polyamines are essential for the growth, the maintenance and the function of normal cells. The complexity of their metabolism and the fact that polyamines homeostasis is tightly regulated support the idea that polyamines are essential to cell survival. Multiple abnormalities in the control of polyamines metabolism might be implicated in several pathological processes. This paper summarises the knowledge about polyamines metabolism and point out the importance of these molecules as a target for the development of therapeutic tools and nutritional strategy.
Moinard
Christophe
C
Laboratoire de Biologie de la Nutrition EA 2498, Faculté de Pharmacie, 4, avenue de l'observatoire, 75270 Paris Cedex 06, France. christophe.moinard@univ-paris5.fr
Cynober
Luc
L
de Bandt
Jean-Pascal
JP
D000107:Acetylation; D000818:Animals; D015317:Biogenic Polyamines / Q000378:metabolism / Q000502:physiology*; D001692:Biological Transport / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D009952:Ornithine / Q000378:metabolism; D011073:Polyamines / Q000378:metabolism*
D015317:Biogenic Polyamines; D011073:Polyamines; D009952:Ornithine