[Treatment with peg-interferon-alpha of patients with chronic hepatitis C].
OBJECTIVE
To investigate a comparative efficacy of treatment with different types of interferon.


METHODS
We studied comparative effectiveness of alpha-interferon vs pegilated interferon. In both cases alpha-interferon was administered in combination with ribavirin. 98 patients (age 16-65 years) with chronic HCV infection have undergone serological, virological, biochemical and histological tests for diagnosis and characterization of HCV infection. HCV genotyping was done by sequencing-based technology.


RESULTS
It is shown that treatment with pegilated interferon-alpha in combination with ribavirin resulted in a higher rate of sustained viral response. Adverse reactions were less frequent with peg-interferon vs conventional interferon therapy.


CONCLUSIONS
Treatment with peg-interferon-alpha in combination with ribavirin is more effective than conventional interferon therapy.
Barbakadze
E I
EI
Pipin
G V
GV
Kamkamidze
G K
GK
D000293:Adolescent; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols; D011994:Recombinant Proteins
D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; C417083:peginterferon alfa-2b