Tracking the dynamics of T-cell activation in response to Salmonella infection.
Despite the current availability of Salmonella vaccines, typhoid fever remains a significant public health problem in developing countries. A greater understanding of T-cell activation and the development of immunological memory during Salmonella infection should lead to the development of more effective prophylactic intervention. Here, we review recent literature on the initiation, expansion and memory development of T-cell responses using the mouse model of typhoid. We pay particular attention to strategies for tracking T-cell responses in vivo and ex vivo, and suggest models to integrate some these studies.
Ravindran
Rajesh
R
Department of Medicine, Division of Immunology, University of Connecticut Health Center, Farmington, CT 06030, USA. mcsorley@uchc.edu
McSorley
Stephen J
SJ
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D003906:Developing Countries; D006801:Humans; D007156:Immunologic Memory; D008213:Lymphocyte Activation; D051379:Mice; D008817:Mice, Mutant Strains; D023421:Models, Animal; D012486:Salmonella typhimurium; D013601:T-Lymphocytes / Q000276:immunology*; D014435:Typhoid Fever / Q000276:immunology* / Q000382:microbiology; D014436:Typhoid-Paratyphoid Vaccines
D014436:Typhoid-Paratyphoid Vaccines