Acetogenins from Annonaceae: recent progress in isolation, synthesis and mechanisms of action.
The aim of the present review is to summarise the knowledge about newly isolated acetogenins (ACGs) in the last six years. It will also report the total syntheses that have allowed either the confirmation or the revision of some structures, together with the biological activities and mechanism of action of such interesting natural products. In fact, of the 417 isolated compounds reviewed, over 176 have been added during the period from 1998 to 2004.
Bermejo
Almudena
A
Laboratoire de Pharmacognosie, associe au CNRS (BIOCIS), Faculte de Pharmacie, Universite Paris-Sud, 92296, Chatenay-Malabry, France. bruno.figadere@cep.u-psud.fr.
Figadere
Bruno
B
Zafra-Polo
Maria-Carmen
MC
Barrachina
Isabel
I
Estornell
Ernesto
E
Cortes
Diego
D
D054378:Acetogenins; D029061:Annonaceae / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D005233:Fatty Alcohols / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D007783:Lactones / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure
D054378:Acetogenins; D000972:Antineoplastic Agents, Phytogenic; D005233:Fatty Alcohols; D007783:Lactones