Studies on the role of ascorbic acid on nickel induced hepatic nucleic acid concentrations in rats.
We studied the effect of oral treatment with ascorbic acid (50 mg/100 g body weight) on nickel sulfate-induced (2.0 mg/100 g body weight, i.p.) alteration of nucleic acids and total protein concentration in the liver of Wistar strain male albino rats. Nucleic acids and total protein concentrations in treated rats decreased significantly when compared with untreated controls. The simultaneous administration of ascorbic acid with nickel sulfate resulted in a remarkable improvement of nucleic acids and total protein concentrations in liver in comparison with rats treated with nickel sulfate only. The results indicate that nickel influences the expression of genetic information by reducing hepatic DNA, RNA, and protein concentration in animals. Simultaneous treatment with ascorbic acid was beneficial for fighting against nickel-induced hepatoxicity.
Das
Kusal K
KK
Department of Physiology, Al-Ameen Medical College, Bijapur 586108, Karnataka, India. kkdas@alameenmedical.org
Das
Swastika N
SN
D000284:Administration, Oral; D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000502:physiology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D009532:Nickel / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D009696:Nucleic Acids / Q000096:biosynthesis* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D009696:Nucleic Acids; C029938:nickel sulfate; D009532:Nickel; D001205:Ascorbic Acid