title: A novel three-component reaction designed by the combinatorial method: heteroarenes, isothiocyanates and isocyanides.
abstract: The novel three-component reaction of isoquinoline with isothiocyanates and isocyanides leads to a variety of new imidazoisoquinolines. The zwitterionic ground state of these new ring systems is established by means of NMR and X-ray analysis. Use of phthalazine instead of isoquinoline gives access to imidazole annulated phthalazines.
authors.affiliation: Department of Technology of Organic Synthesis (TOSLab), Urals State Technical University, 620002 Ekaterinburg, Russian Federation. mir@htf.ustu.ru
authors.forename: Maxim A
authors.initials: MA
authors.lastname: Mironov
authors.forename: Sergey S
authors.initials: SS
authors.lastname: Maltsev
authors.forename: Vladimir S
authors.initials: VS
authors.lastname: Mokrushin
authors.forename: Vasiliy A
authors.initials: VA
authors.lastname: Bakulev
mesh_terms: D003486:Cyanides / Q000138:chemical synthesis / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007202:Indicators and Reagents; D007546:Isoquinolines / Q000737:chemistry; D017879:Isothiocyanates / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation
chemical_list: D003486:Cyanides; D006571:Heterocyclic Compounds; D007202:Indicators and Reagents; D007546:Isoquinolines; D017879:Isothiocyanates