[Inflammatory ointment from shea butter and hydro-alcoholic extract of Khaya senegalensis barks (Cailcederat)].
In a former study, it was proved that the alcoholic solution of hydro-alcoholic extract of Khaya senegalensis barks had an anti-inflammatory activity on animals after a local application. In this work, ointments made from the same extract and three different excipients (vaseline, lanoline and shea butter (crude and refined)) have been prepared and tested by the method of the croton oil inhibited ear oedema. Results showed inhibition percentages of the ear oedema of 58.8%, 66.7% and 75.4% when the hydro-alcoholic extract was tested at respective doses of 1%, 2% and 3% in shea butter. The two other excipients, (vaceline and Lanoline) tested at the dose of 3% showed between 52% and 58% of inhibitions. The interest of this study was to demonstrate the possibility to maintain the anti-inflammatory activity of Khaya senegalensis barks by using them in a galenic form, easy to prepare and which is, in addition, more adapted than the extract to possible clinical trials.
Thioune
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Laboratoire de Pharmacie Galénique, Faculté de Médecine et de Pharmacie de Dakar, Sénégal.
Ahodikpe
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Dieng
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M
Diop
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AB
Ngom
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Lo
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D000279:Administration, Cutaneous; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003436:Croton Oil; D003907:Dexamethasone / Q000627:therapeutic use; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004427:Ear Diseases / Q000139:chemically induced / Q000188:drug therapy; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005079:Excipients / Q000494:pharmacology / Q000627:therapeutic use*; D007213:Indomethacin / Q000627:therapeutic use; D007809:Lanolin / Q000627:therapeutic use; D016488:Medicine, African Traditional; D029582:Meliaceae; D051379:Mice; D009824:Ointments; D009829:Oleic Acids / Q000494:pharmacology / Q000627:therapeutic use*; D010577:Petrolatum / Q000627:therapeutic use; D008517:Phytotherapy / Q000379:methods* / Q000592:standards; D024301:Plant Bark; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D010938:Plant Oils / Q000494:pharmacology / Q000627:therapeutic use*; D012675:Senegal
D000893:Anti-Inflammatory Agents; D005079:Excipients; D009824:Ointments; D009829:Oleic Acids; D010936:Plant Extracts; D010938:Plant Oils; C434349:shea oleine; D003907:Dexamethasone; D003436:Croton Oil; D007809:Lanolin; D010577:Petrolatum; D007213:Indomethacin