Unsuccessful treatment of extragenital lichen sclerosus with topical 1% pimecrolimus cream.
Lichen sclerosus most commonly affects the anogenital region. Spreading into the extragenital regions is rare, and its course is most commonly asymptomatic. Women have been reported to be affected 6 to 10 times more often than men. The etiology of lichen sclerosus is still unknown. The disease is characterized by ivory-white atrophic plaques, and no treatment ensuring complete recovery is available. T-cells are also involved in its pathogenesis. Pimecrolimus is a topical inhibitor of T-cells. In the present paper, we present a male patient with lichen sclerosus located only in extragenital regions and report an unsuccessful outcome of treatment with pimecrolimus 1% cream administered topically twice a day for 16 weeks.
Arican
Ozer
O
Department of Dermatology, Kahramanmaras Sutcu Imam University, Faculty of Medicine, Kahramanmaras, Turkey.
Ciralik
Harun
H
Sasmaz
Sezai
S
D000279:Administration, Cutaneous; D000368:Aged; D001415:Back; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D006801:Humans; D018459:Lichen Sclerosus et Atrophicus / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009333:Neck; D012782:Shoulder; D016559:Tacrolimus / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D017211:Treatment Failure
D003879:Dermatologic Agents; C117268:pimecrolimus; D016559:Tacrolimus