Isocitrate lyase (AceA) is required for Salmonella persistence but not for acute lethal infection in mice.
Isocitrate lyase is required for fatty acid utilization via the glyoxylate shunt. Although isocitrate lyase is essential for Salmonella persistence during chronic infection, it is dispensable for acute lethal infection in mice. Substrate availability in the phagosome appears to evolve over time, with increasing fatty acid dependence during chronic infection.
Fang
Ferric C
FC
Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195-7242, USA. fcfang@u.washington.edu
Libby
Stephen J
SJ
Castor
Margaret E
ME
Fung
Angela M
AM
D000208:Acute Disease; D000818:Animals; D005260:Female; D007522:Isocitrate Lyase / Q000502:physiology*; D051379:Mice; D008809:Mice, Inbred C3H; D012481:Salmonella Infections, Animal / Q000209:etiology* / Q000382:microbiology; D012486:Salmonella typhimurium / Q000201:enzymology* / Q000254:growth & development
D007522:Isocitrate Lyase