title: Cytotoxic 4-phenylcoumarins from the leaves of Marila pluricostata.
abstract: Bioassay-guided fractionation of the CH(2)Cl(2) extract of the leaves of Marila pluricostata led to the isolation of 17 naturally occurring 4-phenylcoumarins, three of them, 5-hydroxy-8,8-dimethyl-4-phenyl-9,10-dihydro-8H-pyrano-[2,3-f]chromen-2-one (1), 5-hydroxy-8,8-dimethyl-4-phenyl-6-propionyl-9,10-dihydro-8H-pyrano-[2,3-f]chromen-2-one (2), and 5,7-dihydroxy-8-(3-methylbut-2-enyl)-4-phenylchromen-2-one (3), are new natural compounds; the remaining (4-17) are known mammea-type coumarins. Their structures were established by spectroscopic means. All compounds were tested in cytotoxicity assays against the MCF-7, H-460, and SF-268 human cancer cell lines.
authors.affiliation: Departamento de Química Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, Campus Unamuno, E-37007, Salamanca, Spain. lopez@usal.es
authors.forename: José L
authors.initials: JL
authors.lastname: López-Pérez
authors.forename: Dionisio A
authors.initials: DA
authors.lastname: Olmedo
authors.forename: Esther
authors.initials: E
authors.lastname: Del Olmo
authors.forename: Yelkaira
authors.initials: Y
authors.lastname: Vásquez
authors.forename: Pablo N
authors.initials: PN
authors.lastname: Solís
authors.forename: Mahabir P
authors.initials: MP
authors.lastname: Gupta
authors.forename: Arturo
authors.initials: A
authors.lastname: San Feliciano
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D028084:Clusiaceae / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular; D010176:Panama; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins