Adipose tissue as an active endocrine organ: recent advances.
Adipose tissue secretes a variety of factors in a manner dependent upon its metabolic state. These factors are derived from adipocyte or non-adipocyte fractions, and include proteins, metabolites and hormones. Obesity is a major risk factor for type 2 diabetes and cardiovascular disease, and adipocyte-derived factors might contribute to or ameliorate obesity-associated pathologies such as insulin resistance, dyslipidemia, vascular dysfunction and a chronic inflammatory and prothrombotic state.
Gimeno
Ruth E
RE
Department of Cardiovascular and Metabolic Diseases, Wyeth Research, Cambridge, MA 02140, USA. rgimeno@wyeth.com
Klaman
Lori D
LD
D000273:Adipose Tissue / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D004703:Endocrine System / Q000378:metabolism / Q000502:physiology*; D006801:Humans