title: Testicular mixed germ cell tumor with polyembryoma component in brothers.
abstract: We report the case of a 17-year-old male with a testicular tumor and high serum levels of alpha-fetoprotein. The patient was treated with surgery followed by combination chemotherapy with bleomycin, etoposide, and cisplatin. Histologic examination showed features of a mixed germ cell tumor composed of mature teratoma, immature teratoma, embryonal carcinoma, yolk sac tumor, and polyembryoma. He is currently well, and his serum levels of alpha-fetoprotein have been normal more than 5 months after treatment. His brother, aged 17 years at the time, had a similar tumor removed from the right testicle 5 years previously.
authors.affiliation: Department of Pathology, Kahramanmaras Sutcuimam University Medical School, 46050 Kahramanmaras, Turkey. sevgiba@superonline.com
authors.forename: Sevgi
authors.initials: S
authors.lastname: Bakaris
authors.forename: Sefa
authors.initials: S
authors.lastname: Resim
authors.forename: Nurdan
authors.initials: N
authors.lastname: Tunali
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism; D001761:Bleomycin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D035781:Siblings; D013736:Testicular Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D000509:alpha-Fetoproteins; D001761:Bleomycin; D005047:Etoposide; D002945:Cisplatin