Frequency distribution of dextromethorphan O-demethylation in a Greek population.
OBJECTIVE
To determine the CYP2D6 phenotype in a Greek population by using dextromethorphan (DM) as a probe drug.


METHODS
DM (30 mg) was given orally to 102 unrelated Greek subjects and 8-hour urine samples were collected. Concentrations of DM and its metabolite dextrorphan (DX) were determined using a validated HPLC assay. Metabolic molar ratio (MR) of DM to free DX in log form was used as an in vivo index of metabolic status.


RESULTS
The frequency distribution histogram of MR was bimodal. An antimode of 0.25 for the mean log MR was determined using probit analysis. Seven of 102 subjects (6.9%) were poor metabolizers (PMs).


CONCLUSIONS
The PM frequency of CYP2D6 in Greek subjects was similar to other Caucasian populations.
Kimiskidis
V K
VK
Department of Neurology, George Papanicolaou Hospital, Aristotle University, Thessaloniki, Greece.
Niopas
I
I
Firinidis
P D
PD
Kanaze
F I
FI
Gabrieli
C
C
Kazis
D
D
Papagiannopoulos
S
S
Kazis
A
A
D000328:Adult; D000368:Aged; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism* / Q000652:urine; D005260:Female; D005828:Genetics, Population; D006115:Greece; D006801:Humans; D008297:Male; D008875:Middle Aged; D010090:Oxidoreductases, O-Demethylating / Q000378:metabolism* / Q000652:urine; D010641:Phenotype; D011110:Polymorphism, Genetic
D003577:Cytochrome P-450 Enzyme System; D010090:Oxidoreductases, O-Demethylating; C052861:dextromethorphan O-demethylase; D019389:Cytochrome P-450 CYP2D6