Bone regeneration in the rat mandible with bone morphogenetic protein-2: a comparison of two carriers.
OBJECTIVE
To compare mandibular bone regeneration with bone morphogenetic protein-2 (BMP-2) delivered with two carriers: a hyaluronic acid polymer (HY), and a collagen carrier complexed with calcium hydroxyapatite and tricalcium phosphate (collagen/HA/TCP).


METHODS
Defects were created in the bilateral mandibular bodies of 16 Sprague-Dawley rats. The defects were filled with the HY carrier, the HY carrier loaded with BMP-2, the collagen/HA/TCP carrier, or the collagen/HA/TCP carrier loaded with BMP-2. Animals were euthanatized after 6 weeks, and the hemi-mandibles were analyzed histomorphologically.


RESULTS
Specimens containing BMP-2 had significantly larger new bone and marrow volumes than control specimens. Specimens in the hyaluronan/BMP-2 group tended to have larger volumes of new bone and osteoid than collagen/HA/TCP/BMP-2 specimens, though these differences were not statistically significant.


CONCLUSIONS
The HY and collagen/HA/TCP carriers had comparable efficacy for bone healing with BMP-2.


CONCLUSIONS
Bone morphogenetic proteins can be delivered with commercially available alloplasts as osteogenic bone substitutes for the repair of craniofacial bone defects.


METHODS
B-2.
Arosarena
Oneida A
OA
Division of Otolaryngology, Department of Surgery, University of Kentucky Medical Center, 800 Rose Street, Room C236, Lexington, KY 40536-0293, USA. oaaros2@pop.uky.edu
Collins
Wesley L
WL
D000818:Animals; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology*; D001861:Bone Regeneration / Q000187:drug effects*; D002130:Calcium Phosphates / Q000494:pharmacology; D003094:Collagen; D004337:Drug Carriers; D006820:Hyaluronic Acid / Q000494:pharmacology; D006882:Hydroxyapatites; D008297:Male; D008334:Mandible / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000494:pharmacology; D016212:Transforming Growth Factor beta / Q000494:pharmacology*
C525720:Bmp2 protein, rat; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D002130:Calcium Phosphates; D004337:Drug Carriers; D006882:Hydroxyapatites; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; D006820:Hyaluronic Acid; D003094:Collagen; C018392:tricalcium phosphate