title: Anti-invasive activity of niacin and trigonelline against cancer cells.
abstract: The effects of niacin, namely, nicotinic acid and nicotinamide, and trigonelline on the proliferation and invasion of cancer cells were studied using a rat ascites hepatoma cell line of AH109A in culture. Niacin and trigonelline inhibited the invasion of hepatoma cells at concentrations of 2.5-40 microM without affecting proliferation. Hepatoma cells previously cultured with a reactive oxygen species (ROS)-generating system showed increased invasive activity. Niacin and trigonelline suppressed this ROS-potentiated invasive capacity through simultaneous treatment of AH109A cells with the ROS-generating system. The present study indicates for the first time the anti-invasive activities of niacin and trigonelline against cancer cells.
authors.affiliation: Department of Applied Biological Science, Tokyo Noko University, Fuchu, Japan.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Hirakawa
authors.forename: Rieko
authors.initials: R
authors.lastname: Okauchi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Miura
authors.forename: Kazumi
authors.initials: K
authors.lastname: Yagasaki
mesh_terms: D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D045744:Cell Line, Tumor; D005434:Flow Cytometry; D008114:Liver Neoplasms, Experimental / Q000473:pathology*; D009361:Neoplasm Invasiveness / Q000517:prevention & control*; D009525:Niacin / Q000494:pharmacology*; D051381:Rats; D017382:Reactive Oxygen Species
chemical_list: D000470:Alkaloids; D017382:Reactive Oxygen Species; D009525:Niacin; C009560:trigonelline