Effect of hyperprolinemia on acetylcholinesterase and butyrylcholinesterase activities in rat.
We observed here that acute proline (Pro) administration provoked a decrease (32%) of acetylcholinesterase (AChE) activity in cerebral cortex and an increase (22%) of butyrylcholinesterase (BuChE) activity in the serum of 29-day-old rats. In contrast, chronic administration of Pro did not alter AChE or BuChE activities. Furthermore, pretreatment of rats with vitamins E and C combined or alone, N(omega)-nitro-L-arginine methyl ester or melatonin prevented the reduction of AChE activity caused by acute Pro administration, suggesting the participation of oxidative stress in such effects.
Delwing
D
D
Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Chiarani
F
F
Wannmacher
C M D
CM
Wajner
M
M
Wyse
A T S
AT
D000110:Acetylcholinesterase / Q000009:adverse effects*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002091:Butyrylcholinesterase / Q000097:blood*; D002525:Cerebellar Cortex / Q000201:enzymology*; D008659:Metabolic Diseases / Q000097:blood* / Q000139:chemically induced; D018384:Oxidative Stress / Q000187:drug effects; D011392:Proline / Q000008:administration & dosage / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar
D011392:Proline; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase