title: Analysis of blood flow in the entire coronary arterial tree.
abstract: A hemodynamic analysis of coronary blood flow must be based on the measured branching pattern and vascular geometry of the coronary vasculature. We recently developed a computer reconstruction of the entire coronary arterial tree of the porcine heart based on previously measured morphometric data. In the present study, we carried out an analysis of blood flow distribution through a network of millions of vessels that includes the entire coronary arterial tree down to the first capillary branch. The pressure and flow are computed throughout the coronary arterial tree based on conservation of mass and momentum and appropriate pressure boundary conditions. We found a power law relationship between the diameter and flow of each vessel branch. The exponent is approximately 2.2, which deviates from Murray's prediction of 3.0. Furthermore, we found the total arterial equivalent resistance to be 0.93, 0.77, and 1.28 mmHg.ml(-1).s(-1).g(-1) for the right coronary artery, left anterior descending coronary artery, and left circumflex artery, respectively. The significance of the present study is that it yields a predictive model that incorporates some of the factors controlling coronary blood flow. The model of normal hearts will serve as a physiological reference state. Pathological states can then be studied in relation to changes in model parameters that alter coronary perfusion.
authors.affiliation: Dept. of Biomedical Engineering, Univ. of California, Irvine, 204 Rockwell Engineering Center, Irvine, CA 92697-2715, USA.
authors.forename: N
authors.initials: N
authors.lastname: Mittal
authors.forename: Y
authors.initials: Y
authors.lastname: Zhou
authors.forename: C
authors.initials: C
authors.lastname: Linares
authors.forename: S
authors.initials: S
authors.lastname: Ung
authors.forename: B
authors.initials: B
authors.lastname: Kaimovitz
authors.forename: S
authors.initials: S
authors.lastname: Molloi
authors.forename: G S
authors.initials: GS
authors.lastname: Kassab
mesh_terms: D000818:Animals; D001776:Blood Circulation Time; D001794:Blood Pressure; D003198:Computer Simulation; D003326:Coronary Circulation / Q000502:physiology*; D003331:Coronary Vessels / Q000502:physiology*; D008955:Models, Cardiovascular; D013552:Swine; D014655:Vascular Resistance