title: Relationship of C-reactive protein and bone mineral density in community-dwelling elderly females.
abstract: OBJECTIVE
  Inflammatory cytokines have been shown to play an important role in bone remodeling. We hypothesized that higher levels of C-reactive protein (CRP) are associated with low bone mineral density (BMD) in elderly females.
  
  
  METHODS
  Secondary data analysis of the Third National Health and Nutrition Examination Survey.
  
  
  METHODS
  2,807 females 65 years and older.
  
  
  RESULTS
  CRP was associated with BMD in the bivariate sis (p<0.001) but not in the multivariate analysis (p=0.23) Age, ethnicity, body mass index (BMI), hormone replacement therapy (HRT) and immobility were independently associated with BMD.
  
  
  CONCLUSIONS
  CRP may be useful in screening for osteoporosis among community-dwelling elderly females. However, CRP appears to act as a surrogate for other factorsdirectly associated with osteoporosis. Further studies are needed to validate these findings.
authors.affiliation: Divisions of General Internal Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA. kaganesa@cdrewu.edu
authors.forename: Kalpana
authors.initials: K
authors.lastname: Ganesan
authors.forename: Senait
authors.initials: S
authors.lastname: Teklehaimanot
authors.forename: The-Huy
authors.initials: TH
authors.lastname: Tran
authors.forename: Merlyn
authors.initials: M
authors.lastname: Asuncion
authors.forename: Keith
authors.initials: K
authors.lastname: Norris
mesh_terms: D000368:Aged; D015519:Bone Density; D002097:C-Reactive Protein / Q000032:analysis*; D005260:Female; D006306:Health Surveys; D006801:Humans; D015999:Multivariate Analysis
chemical_list: D002097:C-Reactive Protein