Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology.
Lipophilic phosphonium cations were first used to investigate mitochondrial biology by Vladimir Skulachev and colleagues in the late 1960s. Since then, these molecules have become important tools for exploring mitochondrial bioenergetics and free radical biology. Here we review why these molecules are useful in mitochondrial research and outline some of the ways in which they are now being utilized.
Ross
M F
MF
MRC Dunn Human Nutrition Unit, Cambridge, CB2 2XY, UK.
Kelso
G F
GF
Blaikie
F H
FH
James
A M
AM
Cochemé
H M
HM
Filipovska
A
A
Da Ros
T
T
Hurd
T R
TR
Smith
R A J
RA
Murphy
M P
MP
D002412:Cations / Q000737:chemistry / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology*; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000737:chemistry / Q000378:metabolism*
D002412:Cations; D005609:Free Radicals; D009943:Organophosphorus Compounds