title: Synthesis of 2-N,N-dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo[b,f]furo[2,3-d]oxepine derivatives as potential anxiolytic agents. Part 2: substitutions by methyl groups on the tetrahydrofuran ring.
abstract: New synthesis approaches that have led to a series of novel tetrahydrodibenzo[b,f]furo[2,3-d]oxepine derivatives are described. A systematic synthetic approach for the introduction of small carbon substituents (methyl groups) around the tetrahydrofuran moiety of tetrahydrodibenzo[b,f]furo[2,3-d]oxepine derivatives is reported. Preliminary pharmacological data of the newly synthesised compounds are also communicated.
authors.affiliation: Johnson and Johnson Pharmaceutical Research and Development, Division of Janssen-Cilag S.A., Jarama 75, 45007 Toledo, Spain. atrabanc@prdes.jnj.com <atrabanc@prdes.jnj.com>
authors.forename: Andrés A
authors.initials: AA
authors.lastname: Trabanco
authors.forename: José M
authors.initials: JM
authors.lastname: Alonso
authors.forename: José M
authors.initials: JM
authors.lastname: Cid
authors.forename: Luis Miguel
authors.initials: LM
authors.lastname: Font
authors.forename: Anton
authors.initials: A
authors.lastname: Megens
mesh_terms: D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001572:Benzofurans / Q000138:chemical synthesis* / Q000494:pharmacology; D001665:Binding Sites; D005663:Furans / Q000737:chemistry*; D010082:Oxepins / Q000138:chemical synthesis* / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D014151:Anti-Anxiety Agents; D001572:Benzofurans; D005663:Furans; D010082:Oxepins; C018674:tetrahydrofuran