Inflammatory myofibroblastic tumor of the posterior mediastinum: an older adult case with anaplastic lymphoma kinase abnormalities determined using immunohistochemistry and fluorescence in situ hybridization.
Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm that usually occurs in children and young adults. Anaplastic lymphoma kinase (ALK) abnormalities in IMT, determined using immunohistochemistry and/or molecular genetic studies, including fluorescence in situ hybridization (FISH), have almost been limited to children and young adults. In elderly cases of IMT, these ALK abnormalities are very rare. We report on a case of IMT arising in the posterior mediastinum of a 59-year-old Japanese man that showed ALK abnormalities determined using immunohistochemistry and FISH, suggesting the neoplastic nature of a subset of IMTs in older patients similar to those in younger ones and the presence of an additional mechanism(s) that allows them to start to grow late.
Makimoto
Yoshifumi
Y
Department of Pathology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka , Japan.
Nabeshima
Kazuki
K
Iwasaki
Hiroshi
H
Ishiguro
Akiko
A
Miyoshi
Tatsu
T
Shiraishi
Takeshi
T
Iwasaki
Akinori
A
Shirakusa
Takayuki
T
D000077548:Anaplastic Lymphoma Kinase; D014408:Biomarkers, Tumor / Q000378:metabolism; D003937:Diagnosis, Differential; D005347:Fibroblasts / Q000201:enzymology / Q000473:pathology; D005350:Fibroma / Q000175:diagnosis; D015321:Gene Rearrangement; D006801:Humans; D007124:Immunoenzyme Techniques; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008479:Mediastinal Neoplasms / Q000201:enzymology / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009379:Neoplasms, Muscle Tissue / Q000201:enzymology / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D018319:Neurofibrosarcoma / Q000175:diagnosis; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D013902:Radiography, Thoracic; D020794:Receptor Protein-Tyrosine Kinases; D016896:Treatment Outcome
D014408:Biomarkers, Tumor; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases