Effect of ethanol consumption on colon cancer in an experimental model.
OBJECTIVE
The present study was designed to examine the effect of an ethanol supplement on experimental colon carcinogenesis.


METHODS
One hundred and ten 10-week-old Sprague-Dawley rats were divided into five groups: group A (20 rats) received no treatment. Group B (20 rats) received a supplement of ethanol at 1.23 g/kg of body weight per day added to their drinking water for 24 weeks. Group C (30 rats) received 18 weekly doses of dimethylhydrazine (DMH) at 21 mg/kg of body weight from the beginning of the study. Group D (20 rats) received ethylen-diamin-tetracetic acid (EDTA) solution only for 18 weeks. Group E (20 rats) received ethanol at the same dose as group B plus DMH injections at the same dose as the rats in group C from the beginning of the study. All experimental animals were sacrificed after 25-27 weeks.


RESULTS
No significant differences in the number of rats that developed tumors, number of tumor-free animals, and number of tumors per rat, as well as in macro-microscopic tumoral findings were observed for animals in group C compared to animals in group E.


CONCLUSIONS
We concluded that the addition of an ethanol supplement does not modify colorectal carcinogenesis using a dynamic model of tumor induction with DMH.
Pérez-Holanda
S
S
Department of Surgery, Hospital Grande Covián, Arriondas, Asturias, Spain. direccionmedica.gae6@sespa.princast.es
Rodrigo
L
L
Viñas-Salas
J
J
Piñol-Felis
C
C
D019813:1,2-Dimethylhydrazine / Q000008:administration & dosage; D000818:Animals; D002273:Carcinogens / Q000008:administration & dosage; D003110:Colonic Neoplasms / Q000139:chemically induced*; D004195:Disease Models, Animal; D000431:Ethanol / Q000008:administration & dosage; D005260:Female; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D002273:Carcinogens; D000431:Ethanol; D019813:1,2-Dimethylhydrazine