title: Composite organic-inorganic nanoparticles (COINs) with chemically encoded optical signatures.
abstract: To obtain a coding system for multiplex detection, we have developed a method to synthesize a new type of nanomaterial called composite organic-inorganic nanoparticles (COINs). The method allows the incorporation of a broad range of organic compounds into COINs to produce surface enhanced Raman scattering (SERS)-like spectra that are richer in variety than fluorescence-based signatures. Preliminary data suggest that COINs can be used as Raman tags for multiplex and ultrasensitive detection of biomolecules.
authors.affiliation: Biotechnology Research Group, Intel Research and CTM, Intel Corporation, SC2-24, 2200 Mission College Boulevard, Santa Clara, California 95054, USA. xing.su@intel.com
authors.forename: Xing
authors.initials: X
authors.lastname: Su
authors.forename: Jingwu
authors.initials: J
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Sun
authors.forename: Tae-Woong
authors.initials: TW
authors.lastname: Koo
authors.forename: Selena
authors.initials: S
authors.lastname: Chan
authors.forename: Narayan
authors.initials: N
authors.lastname: Sundararajan
authors.forename: Mineo
authors.initials: M
authors.lastname: Yamakawa
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Berlin
mesh_terms: D006046:Gold / Q000737:chemistry*; D007118:Immunoassay; D007376:Interleukin-2 / Q000032:analysis; D016209:Interleukin-8 / Q000032:analysis; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry*; D009566:Nitrates / Q000737:chemistry; D009930:Organic Chemicals / Q000737:chemistry*; D012680:Sensitivity and Specificity; D012834:Silver / Q000737:chemistry*; D012835:Silver Nitrate / Q000737:chemistry; D013059:Spectrum Analysis, Raman / Q000379:methods*
chemical_list: D007376:Interleukin-2; D016209:Interleukin-8; D009566:Nitrates; D009930:Organic Chemicals; D012834:Silver; D006046:Gold; C031618:sodium nitrate; D012835:Silver Nitrate