The influence of aromatic residues in hydraphile spacer units: assay by ion selective electrode methods and in bacteria.
A small library of hydraphiles has been prepared that incorporates either 1,4-phenylenedioxy or 2,6-naphthalenedioxy within the spacer chains. The side chains attached to the distal macrocycles in these tris(macrocyclic) compounds are either n-dodecyl or benzyl. The presence of the arenes subunits significantly affect sodium cation release from vesicles. The efficacy of ion transport is paralleled by the toxicity of these compounds to Bacillus subtilis.
Meyer
Adam E
AE
Department of Chemistry, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8103, St. Louis, MO 63110, USA.
Leevy
W Matthew
WM
Pajewski
Robert
R
Suzuki
Iwao
I
Weber
Michelle E
ME
Gokel
George W
GW
D001412:Bacillus subtilis / Q000187:drug effects* / Q000254:growth & development; D002412:Cations / Q000737:chemistry / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D006841:Hydrocarbons, Aromatic / Q000737:chemistry* / Q000633:toxicity; D017736:Ion-Selective Electrodes; D015394:Molecular Structure; D010743:Phospholipids / Q000737:chemistry; D012964:Sodium / Q000737:chemistry / Q000378:metabolism; D013997:Time Factors
D002412:Cations; D006841:Hydrocarbons, Aromatic; D010743:Phospholipids; D012964:Sodium