CTX-M-10 linked to a phage-related element is widely disseminated among Enterobacteriaceae in a Spanish hospital.
CTX-M-10 has been widely disseminated among multiple clones of several species of Enterobacteriaceae, harboring seemingly different plasmids, for over a decade in Ramón y Cajal University Hospital, Madrid, Spain. Cloning and sequencing of a 12.2-kb DNA fragment from plasmid pRYCE21 from Klebsiella pneumoniae strain KP4aC revealed a novel phage-related element immediately upstream of bla(CTX-M-10) conserved among different CTX-M-10-producing strains. This is the first report showing an extended-spectrum-beta-lactamase gene linked to a phage-related element.
Oliver
Antonio
A
Servicio de Microbiología, Hospital Son Dureta, C. Andrea Doria No. 55, 07014 Palma de Mallorca, Spain. aoliver@hsd.es
Coque
Teresa M
TM
Alonso
Diana
D
Valverde
Aránzazu
A
Baquero
Fernando
F
Cantón
Rafael
R
D000595:Amino Acid Sequence; D001435:Bacteriophages / Q000235:genetics*; D004755:Enterobacteriaceae / Q000145:classification / Q000201:enzymology / Q000235:genetics; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D006761:Hospitals; D006801:Humans; D007710:Klebsiella Infections / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000235:genetics / Q000821:virology; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics; D017422:Sequence Analysis, DNA; D013030:Spain; D001618:beta-Lactamases / Q000235:genetics*
D001618:beta-Lactamases