Antinuclear antibodies.
The presence of abnormal levels of autoantibodies to intracellular antigens is a hallmark of systemic connective tissue disease. The indirect immunofluorescence assay is the most commonly used routine test for the detection of antinuclear antibodies. In this text, several representative patterns of fluorescence are reviewed and some pitfalls for application of the results to the clinical field are mentioned.
Muro
Yoshinao
Y
Division of Connective Tissue Disease and Autoimmunity, Department of Dermatology Nagoya University Graduate School of Medicine 65 Tsurumai-cho, Showa-ku Nagoya 466-8550 Japan. ymuro@med.nagoya-u.ac.jp
D000818:Animals; D000974:Antibodies, Antinuclear / Q000378:metabolism*; D001327:Autoimmune Diseases / Q000276:immunology; D002460:Cell Line; D002466:Cell Nucleolus / Q000276:immunology; D002467:Cell Nucleus / Q000276:immunology; D003240:Connective Tissue Diseases / Q000276:immunology; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans
D000974:Antibodies, Antinuclear