title: HLA-B27-associated uveitis with a chorioretinitis manifestation.
abstract: A 29-year-old man who had been treated for acute anterior uveitis in a local medical office and observed for 1 month presented complaining of distorted vision in his left eye for 1 week. On ophthalmic examination, the anterior segment was relatively quiet with few cells. A posterior segment examination revealed cystoid macular edema and multiple splinter retinal hemorrhages. Results of all laboratory and imaging studies were negative, except for a positive HLA-B27 haplotype. Fluorescein angiography revealed massive leakage in the mid and late phase, consistent with chorioretinitis. Periocular corticosteroid injections and oral prednisolone were administered. The patient responded to the treatment well with subsequent resolution of chorioretinitis 2 months later. Although rare, chorioretinitis can occur in the setting of uveitis associated with HLA-B27 and seems to respond well to corticosteroid treatment.
authors.affiliation: Department of Ophthalmology, Cathay General Hospital, Taipei, Taiwan.
authors.forename: Jack Yu-Shih
authors.initials: JY
authors.lastname: Lin
authors.forename: Shun-Ling
authors.initials: SL
authors.lastname: Lin
authors.forename: Wei-Lin
authors.initials: WL
authors.lastname: Chen
authors.forename: Ying-Shan
authors.initials: YS
authors.lastname: Chen
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D002825:Chorioretinitis / Q000150:complications* / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D002829:Choroid / Q000473:pathology; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D005938:Glucocorticoids / Q000008:administration & dosage; D015796:HLA-B27 Antigen / Q000235:genetics / Q000378:metabolism*; D006239:Haplotypes; D006801:Humans; D007267:Injections; D008297:Male; D012160:Retina / Q000473:pathology; D014222:Triamcinolone Acetonide / Q000008:administration & dosage; D014606:Uveitis, Anterior / Q000150:complications* / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D014792:Visual Acuity
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D015796:HLA-B27 Antigen; D014222:Triamcinolone Acetonide