Rapid prevention of vertebral fractures associated with osteoporosis.
Osteoporosis affects postmenopausal women and patients on glucocorticoid therapy. Fractures are the most devastating outcome. Patients who experience an osteoporotic vertebral fracture are at substantial risk of experiencing another within 1 year. Risk can be reduced rapidly with antiresorptives. Risedronate reduced the risk of vertebral fracture in patients with post-menopausal or glucocorticoid-induced osteoporosis after 1 year by up to 71% in prospective studies. In post hoc analyses, significant reductions in clinical vertebral fractures were demonstrated after 6 months with risedronate and 1 year with alendronate and raloxifene. Rapid reduction in fracture risk is achievable with the potent therapeutic agents available.
Wallace
Daniel J
DJ
Cedars-Sinai Medical Center/David Geffen School of Medicine at UCLA, Los Angeles, Calif. 90047, USA.
D000368:Aged; D019386:Alendronate / Q000494:pharmacology / Q000627:therapeutic use; D002116:Calcitonin / Q000494:pharmacology / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004164:Diphosphonates / Q000494:pharmacology / Q000627:therapeutic use; D004967:Estrogens / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D000077557:Ibandronic Acid; D007093:Imidazoles / Q000494:pharmacology / Q000627:therapeutic use; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications* / Q000188:drug therapy; D015663:Osteoporosis, Postmenopausal / Q000150:complications / Q000188:drug therapy; D010281:Parathyroid Hormone / Q000494:pharmacology / Q000627:therapeutic use; D012307:Risk Factors; D016103:Spinal Fractures / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome; D000077211:Zoledronic Acid
D004164:Diphosphonates; D004967:Estrogens; D005938:Glucocorticoids; D007093:Imidazoles; D010281:Parathyroid Hormone; D000077211:Zoledronic Acid; D002116:Calcitonin; D000077557:Ibandronic Acid; D019386:Alendronate