Cortical representation of dermatomes: MEG-derived maps after tactile stimulation.
Mechanical stimulation of skin receptors is known to evoke cortical responses arising from the somatosensory cortex. Here we present a magnetoencephalographic (MEG) study where dermatomal somatosensory-evoked fields (DSSEFs) were recorded after mechanical stimulation of sacral (S1), lumbar (L3), thoracic (Th7), and cervical (C4) dermatomes in three healthy volunteers. All MEG measurements were repeated in order to test the replicability of the results. DSSEFs were successfully measured and modeled in all three participants. The topography and temporal dynamics of cortical responses derived after stimulation of each dermatome are described. We found that cortical-evoked responses can be reliably recorded using MEG after mechanical stimulation of dermatomes when a sufficiently large skin region within the dermatome is stimulated. Primary sensory cortex response (SI) to each of the four dermatomes was replicable and showed stability over time. The MEG-derived individual maps of activation confirm the somatotopic representation of dermatomes in primary sensory cortex and the utility of MEG recordings in disentangling the interactions between primary and secondary sensory cortex during somatic perception.
Castillo
Eduardo M
EM
Department of Neurosurgery, Vivian L. Smith Center for Neurologic Research, University of Texas Houston, Medical School, 1333 Moursund Street, Ste. H114, Houston, TX 77030, USA. eduardo.m.castillo@uth.tmc.edu
Papanicolaou
Andrew C
AC
D000328:Adult; D000344:Afferent Pathways / Q000502:physiology; D001931:Brain Mapping; D004292:Dominance, Cerebral / Q000502:physiology; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D008465:Mechanoreceptors / Q000502:physiology*; D010812:Physical Stimulation; D011930:Reaction Time / Q000502:physiology; D012016:Reference Values; D012815:Signal Processing, Computer-Assisted; D012867:Skin / Q000294:innervation*; D013003:Somatosensory Cortex / Q000502:physiology*; D013126:Spinal Nerve Roots / Q000502:physiology; D014110:Touch / Q000502:physiology*