title: The Fenyö-Lindberg scoring system for appendicitis increases positive predictive value in fertile women--a prospective study in 455 patients randomized to either laparoscopic or open appendectomy.
abstract: BACKGROUND
  Suspected appendicitis is one of the most common indications for acute laparotomy or laparoscopy. The negative laparotomy and laparoscopy rates are high, often in the range of 15-30%, and especially high in some groups of patients such as women of child-bearing age and young patients. Different scoring systems have been introduced in order to improve diagnostic accuracy. The aim of the present study was to analyse the outcome of the Fenyö-Lindberg scoring system in a prospectively randomized multicenter trial and to analyze how well the score performed in stratified subgroups.
  
  
  METHODS
  The variables of the Fenyö-Lindberg scoring system were collected in a prospective study comparing laparoscopic and open surgery in suspected appendicitis and with four participating centers. None of the hospitals had used the scoring system previously. Since surgeons were unfamiliar with the score, they could not use it as a diagnostic aid. When comparing the score with the clinical outcome, retrospectively, the investigators interpreting the score were blinded regarding the surgical outcome.
  
  
  RESULTS
  Positive predictive value (PPV) of the Fenyö-Lindberg score was higher than that of the surgeon's clinical diagnosis in the patient cohort [0.90 vs 0.79 (p < 0.001)]. The score demonstrated an improvement of PPV in women [0.83 vs 0.70 (p < 0.01)]. PPV was increased in women between 15 and 50 years of age. In women aged 15-30 years and 31-50 years PPV increased from 0.69 to 0.82 and 0.68 to 0.86, respectively (p < 0.01). Both the sensitivity (0.77) and the specificity (0.69) of the score were, however, low.
  
  
  CONCLUSIONS
  The Fenyö-Lindberg score is an inexpensive clinical tool that may improve the diagnostic accuracy for acute appendicitis in women of childbearing age, which is a group of patients where the diagnostic accuracy usually is low and where the arsenal of diagnostic tools such as computed tomography is limited because of radiation. The low specificity of the score in women of childbearing age must, however, be kept in mind.
authors.affiliation: Department of Surgery, Karolinska Institutet at Huddinge University Hospital, Stockholm, Sweden. Lars.Enochsson@cfss.ki.se
authors.forename: L
authors.initials: L
authors.lastname: Enochsson
authors.forename: T
authors.initials: T
authors.lastname: Gudbjartsson
authors.forename: A
authors.initials: A
authors.lastname: Hellberg
authors.forename: C
authors.initials: C
authors.lastname: Rudberg
authors.forename: J
authors.initials: J
authors.lastname: Wenner
authors.forename: I
authors.initials: I
authors.lastname: Ringqvist
authors.forename: S
authors.initials: S
authors.lastname: Sörensen
authors.forename: G
authors.initials: G
authors.lastname: Fenyö
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001062:Appendectomy / Q000379:methods*; D001064:Appendicitis / Q000175:diagnosis* / Q000601:surgery*; D003938:Diagnostic Techniques, Digestive System; D005260:Female; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D016037:Single-Blind Method