title: Short communication: HIV type 1 phenotype, tropism, and sequence patterns: association and preference.
abstract: In this study, the relationship between biological phenotypes, coreceptor usages, and sequence patterns of V1V2 or V3 regions on HIV-1 envelope gp 120 was carefully analyzed based on the existing isolates in the Los Alamos National Laboratory sequence database. Obviously, SI/NSI phenotypes were closely linked to the capability of HIV-1 to use coreceptor CXCR4, but not CCR5. Moreover, compared to NSI or R5 isolates, SI or X4 HIV-1 isolates significantly prefer higher net charges and the loss of the N-linked glycosylation site in the V3 loop, but they show no preference in either net charge or N-linked glycosylation of the V1V2 region. In addition, no significant relationship between V1V2 length and virus tropism or phenotypes was observed.
authors.affiliation: Laboratory of Immunology, Research Centre for Medical Science and Department of Biology, Tsinghua University, and Protein Science Laboratory of MOE, Beijing 100084, Peoples Republic of China.
authors.forename: Xiao-Nan
authors.initials: XN
authors.lastname: Dong
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Ablikim
authors.initials: A
authors.lastname: Ablimit
authors.forename: Zi
authors.initials: Z
authors.lastname: Ye
authors.forename: Yi
authors.initials: Y
authors.lastname: Wu
authors.forename: Ying-Hua
authors.initials: YH
authors.lastname: Chen
mesh_terms: D006031:Glycosylation; D015699:HIV Envelope Protein gp120 / Q000737:chemistry*; D019302:HIV Envelope Protein gp160 / Q000502:physiology; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D010641:Phenotype; D019713:Receptors, CCR5 / Q000502:physiology; D018523:Tropism
chemical_list: D015699:HIV Envelope Protein gp120; D019302:HIV Envelope Protein gp160; D019713:Receptors, CCR5