Isaacs' syndrome (autoimmune neuromyotonia) in a patient with systemic lupus erythematosus.
Patients with systemic lupus erythematosus (SLE) often produce autoantibodies against a large number of antigens. A case of SLE is presented in which muscle twitching and muscle cramps were associated with an autoantibody directed against the voltage-gated potassium channel of peripheral nerves (Isaacs' syndrome).
Taylor
Philip W
PW
Cape Girardeau Physician Associates, Cape Girardeau, Missouri 63703, USA.
D000588:Amines / Q000627:therapeutic use; D000927:Anticonvulsants / Q000627:therapeutic use; D001323:Autoantibodies / Q000276:immunology; D001379:Azathioprine / Q000627:therapeutic use; D002998:Clonazepam / Q000627:therapeutic use; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D000077206:Gabapentin; D006801:Humans; D020386:Isaacs Syndrome / Q000150:complications* / Q000188:drug therapy / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy / Q000276:immunology*; D008181:Lupus Nephritis / Q000188:drug therapy; D008875:Middle Aged; D024642:Potassium Channels, Voltage-Gated / Q000276:immunology*; D011241:Prednisone / Q000627:therapeutic use; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use
D000588:Amines; D000927:Anticonvulsants; D001323:Autoantibodies; D003509:Cyclohexanecarboxylic Acids; D024642:Potassium Channels, Voltage-Gated; D005680:gamma-Aminobutyric Acid; D002998:Clonazepam; D000077206:Gabapentin; D001379:Azathioprine; D011241:Prednisone