title: [The renoprotect effect of shenhua recipe on 5/6 renal ablation rats].
abstract: OBJECTIVE
  To investigate the reno protective effect of Shenhua recipe on the experimental model of 5/6 renal ablation.
  
  
  METHODS
  5/6 renal ablation rats were underlying this experiment. They were administered Shenhua, irbesartan respectively by gavage during 12 weeks. Body weight, systolic blood pressure, proteinuria, Scr, BUN, total protein, albumin, Glycero and cholesterol were measured. Histologic glomenular and tubulointerstitial damage scores were measured at 12 weeks.
  
  
  RESULTS
  The treated groups showed significantly less histologic glomerular and tubulointerstitial damage scores at 12 weeks. The plasma albumin were higher ( P < 0.05), urine protein excretion rates, serum cholesterol and creatinine were lower than in nontreated group, but arterial blood pressure was not significantly different in the three Shenhua treated groups compared with nontreated group.
  
  
  CONCLUSIONS
  Shenhua can retard the progression of chronic renal injury in the 5/6 renal ablation without changes in systolic blood pressure.
authors.affiliation: Department of nephrology, General Hospital of PLA, Beijing 100853, China.
authors.forename: Jian-jun
authors.initials: JJ
authors.lastname: Li
authors.forename: Xiang-mei
authors.initials: XM
authors.lastname: Chen
authors.forename: Yue
authors.initials: Y
authors.lastname: Gu
authors.forename: Ri-bao
authors.initials: RB
authors.lastname: Wei
authors.forename: Suo-zhu
authors.initials: SZ
authors.lastname: Shi
authors.forename: Zhong
authors.initials: Z
authors.lastname: Yin
mesh_terms: D000418:Albumins / Q000378:metabolism; D000818:Animals; D027885:Astragalus propinquus / Q000737:chemistry; D031174:Atractylodes / Q000737:chemistry; D001794:Blood Pressure / Q000187:drug effects*; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D030024:Curcuma / Q000737:chemistry; D018450:Disease Progression; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D007678:Kidney Glomerulus / Q000473:pathology*; D008297:Male; D009392:Nephrectomy / Q000009:adverse effects / Q000379:methods; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000418:Albumins; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D002784:Cholesterol; D003404:Creatinine