title: Cytotoxic sterol derivatives from a marine sponge Homaxinella sp.
abstract: A bioactivity-guided fractionation of a marine sponge Homaxinella sp. has led to the isolation of three new (1-3) highly degraded sterols and four new 6-O-alkylated (6-9) sterols, along with known sterol derivatives. The degraded sterols (1-5) belong to the class incisterols, previously isolated from the marine sponge Dictyonella incisa. Mainly NMR and MS spectroscopic analyses established the gross structures of the new compounds. The relationship between the stereoisomerism of the side chain and HPLC retention time has also been discussed. The compounds were tested against a panel of five human solid tumor cell lines, and especially the degraded sterols (1-4) displayed significant cytotoxicity.
authors.affiliation: College of Pharmacy, Pusan National University, Busan 609-735, Korea.
authors.forename: Tayyab A
authors.initials: TA
authors.lastname: Mansoor
authors.forename: Jongki
authors.initials: J
authors.lastname: Hong
authors.forename: Chong-O
authors.initials: CO
authors.lastname: Lee
authors.forename: Song-Ja
authors.initials: SJ
authors.lastname: Bae
authors.forename: Kwang Sik
authors.initials: KS
authors.lastname: Im
authors.forename: Jee H
authors.initials: JH
authors.lastname: Jung
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007723:Korea; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010051:Ovarian Neoplasms; D011161:Porifera / Q000737:chemistry*; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D013261:Sterols