Serum IL-6, TNFalpha and CRP levels in Greek colorectal cancer patients: prognostic implications.
OBJECTIVE
The significance of preoperative serum IL-6, TNFalpha and CRP levels in the progression of colorectal cancer (CRC) has not been fully elucidated. Our intention was to investigate their role and identify their prognostic significance.


METHODS
The IL-6, TNFalpha and CRP levels were measured in 74 CRC patients and the relationships between their elevations and both the clinicopathological factors and prognosis of patients were investigated. Serum concentrations of human IL-6 and TNFalpha were determined by enzyme-linked immunosorbent assay (ELISA). CRP was measured by an immunoturbinometric method.


RESULTS
Median IL-6, TNFalpha and CRP levels were significantly higher in CRC patients than in normal controls. High levels of serum IL-6, TNFalpha and CRP were correlated with larger tumor size. Furthermore, high IL-6 and high CRP levels were associated with reduced overall survival.


CONCLUSIONS
Serum IL-6, TNFalpha and CRP levels definitely increase in CRC patients. Pre-operative serum elevation of IL-6 and CRP was thus found to be predictor of the prognosis of CRC patients. The clinical value of TNFalpha in CRC needs to be further investigated.
Nikiteas
Nikolaos I
NI
2nd Propedeutic Department of Surgery, School of Medicine, University of Athens, Athens 11527, Greece. nnkit@med.uoa.gr
Tzanakis
Nikolaos
N
Gazouli
Maria
M
Rallis
George
G
Daniilidis
Kessaris
K
Theodoropoulos
George
G
Kostakis
Alkiviadis
A
Peros
George
G
D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000097:blood* / Q000401:mortality* / Q000473:pathology; D005260:Female; D006115:Greece; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D011379:Prognosis; D016019:Survival Analysis; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D015415:Biomarkers; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein