title: Chemistry-to-gene screens in Caenorhabditis elegans.
abstract: The nematode worm Caenorhabditis elegans is a genetic model organism linked to an impressive portfolio of fundamental discoveries in biology. This free-living nematode, which can be easily and inexpensively grown in the laboratory, is also a natural vehicle for screening for drugs that are active against nematode parasites. Here, we show that chemistry-to-gene screens using this animal model can define targets of antiparasitic drugs, identify novel candidate drug targets and contribute to the discovery of new drugs for treating human diseases.
authors.affiliation: MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK.
authors.forename: Andrew K
authors.initials: AK
authors.lastname: Jones
authors.forename: Steven D
authors.initials: SD
authors.lastname: Buckingham
authors.forename: David B
authors.initials: DB
authors.lastname: Sattelle
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology*; D017173:Caenorhabditis elegans / Q000737:chemistry / Q000235:genetics / Q000254:growth & development; D015195:Drug Design; D004351:Drug Resistance / Q000235:genetics; D017238:Genes, Helminth / Q000235:genetics*; D023421:Models, Animal
chemical_list: D000969:Antinematodal Agents