title: Antinociceptive effect of nicotine in various pain models in the mouse.
abstract: The antinociceptive effect of nicotine administered intracereboventricularly (i.c.v.) or intrathecally (i.t) in several pain models was examined in the present study. We found that i.t. treatment with nicotine (from 5 to 20 g) dose-dependently blocked pain behavior revealed during the second phase, but not during the first phase in the formalin test. In addition, i.c.v. treatment with nicotine (from 0.1 to 10 microg) dose-dependently attenuated pain behavior revealed during both the first and second phases. In addition to the formalin test, nicotine administered i.c.v. or i.t. attenuated acetic acid-induced writhing response. Furthermore, i.c.v. or i.t. administration of nicotine did not cause licking, scratching and biting responses induced by substance P, glutamate, TNF-alpha (100 pg), IL-1beta (100 pg) and INF-gamma (100 pg) injectied i.t. The antinociception induced by supraspinally-administered nicotine appears to be more effective than that resulting from spinally administered nicotine. Our results suggest that nicotine administration induces antinociception by acting on the central nervous system and has differing antinociceptive profiles according to the various pain models.
authors.affiliation: Department of Pharmacology and Institute of Natural Medicine, Hallym University, Gangwon-Do 200-702, Korea.
authors.forename: Ki-Jung
authors.initials: KJ
authors.lastname: Han
authors.forename: Seong-Soo
authors.initials: SS
authors.lastname: Choi
authors.forename: Jin-Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Han-Kyu
authors.initials: HK
authors.lastname: Lee
authors.forename: Eon-Jeong
authors.initials: EJ
authors.lastname: Shim
authors.forename: Min Soo
authors.initials: MS
authors.lastname: Kwon
authors.forename: Young-Jun
authors.initials: YJ
authors.lastname: Seo
authors.forename: Hong-Won
authors.initials: HW
authors.lastname: Suh
mesh_terms: D000700:Analgesics; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D007276:Injections, Intraventricular; D007278:Injections, Spinal; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009538:Nicotine / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000494:pharmacology*; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D010147:Pain Measurement / Q000187:drug effects
chemical_list: D000700:Analgesics; D018722:Nicotinic Agonists; D009538:Nicotine