[Cyclosporin-induced toxic neuromyopathy].
BACKGROUND
Cyclosporine is an immunosuppressive treatment whose side effects limit its usefulness. Among neurological side effects, neuropathies or myopathies have been reported, specially inpatients given combinations of cyclosporine with co-enzyme A reductase inhibitors.


METHODS
We report here the case of a 67-year-old woman who developed few months after a kidney graft sensorimotor disorders which progressed rapidly. Since all etiologies of such a disorder were ruled out, the hypothesis of toxicity exclusively induced by cyclosporine was suggested and confirmed by the improvement observed after its withdrawal.


CONCLUSIONS
This observation highlights the fact that cyclosporine may induce neuromyopathies even when given alone at the therapeutic dosage.
Guennoc
A-M
AM
Clinique Neurologique, CHU Bretoneau, 37044 Tours. guennoc@med.univ-tours.fr
Corcia
P
P
Al-Najjar
A
A
Bergemer-Fouquet
A-M
AM
Lebranchu
Y
Y
de Toffol
B
B
Autret
A
A
D003065:Coenzyme A / Q000378:metabolism; D016572:Cyclosporine / Q000009:adverse effects*; D004576:Electromyography; D005260:Female; D006084:Graft Rejection / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation / Q000276:immunology; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D009431:Neural Conduction / Q000187:drug effects; D009468:Neuromuscular Diseases / Q000139:chemically induced* / Q000473:pathology
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003065:Coenzyme A