The effects of neurotensin on selected parameters of lipid metabolism in rats.
15 nM/kg b.m. of neurotensin (NT) caused a significant inhibition of LMA within 30 min of administration and this effect persisted up for to the 240 th minute of the experiment. A 15 nM/kgb.m. dose also caused a reduction in SLA which persisted up to the 120 th minute. Sixty minutes after an intraperitoneal administration of NT a decrease in the cholesterol and NEFA levels and an increase in the TG and glycerol levels were observed. These effects were inhibited by the NTR2-blocker (levocabastine) and were not subject to change after an in vivo application of SR 48692.
Piatek
J
J
Department of Physiology, University of Medical Sciences, Swiecickiego 6, 60781 Poznan, Poland. DrPiatek@poczta.fm
Witmanowski
H
H
Paluszak
J
J
Krauss
H
H
Krawczyk
J
J
D000818:Animals; D050356:Lipid Metabolism; D008053:Lipid Mobilization / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008297:Male; D009496:Neurotensin / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D008055:Lipids; D009496:Neurotensin