Proteomic fingerprinting for the diagnosis of human African trypanosomiasis.
Papadopoulos et al. recently reported the discovery of a diagnostic serum proteomic signature for human African trypanosomiasis (HAT), using a combination of surface-enhanced laser desorption-ionization time-of-flight (SELDI-TOF) mass spectrometry and data-mining algorithms. This novel approach, coupled with biochemical characterization of the proteins that contribute to the signature, provides powerful new tools for the development of improved diagnostic tests, disease staging and identification of potential novel drug targets in HAT.
Agranoff
Dan
D
Department of Cellular and Molecular Medicine (Infectious Diseases), St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK.
Stich
August
A
Abel
Paulo
P
Krishna
Sanjeev
S
D000465:Algorithms; D000818:Animals; D016172:DNA Fingerprinting / Q000379:methods*; D006801:Humans; D020543:Proteome / Q000032:analysis*; D040901:Proteomics; D015800:Protozoan Proteins / Q000032:analysis; D012680:Sensitivity and Specificity; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods; D014344:Trypanocidal Agents / Q000627:therapeutic use; D014345:Trypanosoma / Q000737:chemistry*; D014353:Trypanosomiasis, African / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics
D020543:Proteome; D015800:Protozoan Proteins; D014344:Trypanocidal Agents