Antinociceptive effect of nicotine in various pain models in the mouse.
The antinociceptive effect of nicotine administered intracereboventricularly (i.c.v.) or intrathecally (i.t) in several pain models was examined in the present study. We found that i.t. treatment with nicotine (from 5 to 20 g) dose-dependently blocked pain behavior revealed during the second phase, but not during the first phase in the formalin test. In addition, i.c.v. treatment with nicotine (from 0.1 to 10 microg) dose-dependently attenuated pain behavior revealed during both the first and second phases. In addition to the formalin test, nicotine administered i.c.v. or i.t. attenuated acetic acid-induced writhing response. Furthermore, i.c.v. or i.t. administration of nicotine did not cause licking, scratching and biting responses induced by substance P, glutamate, TNF-alpha (100 pg), IL-1beta (100 pg) and INF-gamma (100 pg) injectied i.t. The antinociception induced by supraspinally-administered nicotine appears to be more effective than that resulting from spinally administered nicotine. Our results suggest that nicotine administration induces antinociception by acting on the central nervous system and has differing antinociceptive profiles according to the various pain models.
Han
Ki-Jung
KJ
Department of Pharmacology and Institute of Natural Medicine, Hallym University, Gangwon-Do 200-702, Korea.
Choi
Seong-Soo
SS
Lee
Jin-Young
JY
Lee
Han-Kyu
HK
Shim
Eon-Jeong
EJ
Kwon
Min Soo
MS
Seo
Young-Jun
YJ
Suh
Hong-Won
HW
D000700:Analgesics; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D007276:Injections, Intraventricular; D007278:Injections, Spinal; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009538:Nicotine / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000494:pharmacology*; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D010147:Pain Measurement / Q000187:drug effects
D000700:Analgesics; D018722:Nicotinic Agonists; D009538:Nicotine