[Effects of triamcinolone acetonide on leukocyte distribution in blood system, mononuclear liver infiltration, and immune response under conditions of stress-induced hypoxia in rats].
The effect of triamcinolone acetonide (2 mg/kg) on the distribution of morphologically mature leukocytes in the blood system, the mononuclear liver infiltration, and the immune response was studied in rats under conditions of stress-induced hypoxia. Administered under these conditions, the drug produces a less pronounced effect on the content of circulating lymphocytes, the lymphoid cell number in the bone marrow, and the number of hepatocytes and monocytes/macrophages in the liver. However, the post-stressor immunodepressant effect of triamcinolone acetonide was increased and accompanied by the development of hepatic damage.
Volchegorskiĭ
I A
IA
Tseĭlikman
V E
VE
Tseĭlikman
O B
OB
Bubnov
N V
NV
Sinitskiĭ
A I
AI
D000818:Animals; D002465:Cell Movement / Q000187:drug effects* / Q000276:immunology; D005260:Female; D000860:Hypoxia / Q000276:immunology* / Q000473:pathology; D007958:Leukocyte Count; D008099:Liver / Q000276:immunology* / Q000473:pathology; D008214:Lymphocytes / Q000276:immunology / Q000473:pathology; D008264:Macrophages / Q000276:immunology / Q000473:pathology; D008297:Male; D051381:Rats; D013312:Stress, Physiological / Q000276:immunology* / Q000473:pathology; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*
D014222:Triamcinolone Acetonide