title: Micelles based on polyvinyl alcohol substituted with oleic acid for targeting of lipophilic drugs.
abstract: Polymeric micelles based on polyvinyl alcohol substituted with oleic acid were used as vehicles for progesterone and folic acid. The ability of this amphiphilic polymer to entrap lipophilic drugs and to generate stable micelles in aqueous neutral medium makes it a good candidate for drug delivery. The release of the loaded drugs in acidic environments represents another important property of these systems. Size of micelles, their stability, and their drug-loading capacity were evaluated, as well as the in vitro controlled-release profiles at pH 7.4 and 5.5.
authors.affiliation: Department of Pharmaceutical Sciences, Bologna University, Bologna, Italy. bluppi@biocfarm.unibo.it
authors.forename: B
authors.initials: B
authors.lastname: Luppi
authors.forename: F
authors.initials: F
authors.lastname: Bigucci
authors.forename: T
authors.initials: T
authors.lastname: Cerchiara
authors.forename: V
authors.initials: V
authors.lastname: Andrisano
authors.forename: V
authors.initials: V
authors.lastname: Pucci
authors.forename: R
authors.initials: R
authors.lastname: Mandrioli
authors.forename: V
authors.initials: V
authors.lastname: Zecchi
mesh_terms: D016503:Drug Delivery Systems; D004355:Drug Stability; D005492:Folic Acid / Q000008:administration & dosage* / Q000032:analysis / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008823:Micelles; D019301:Oleic Acid / Q000008:administration & dosage*; D011142:Polyvinyl Alcohol / Q000008:administration & dosage*; D011374:Progesterone / Q000008:administration & dosage* / Q000032:analysis / Q000737:chemistry; D012995:Solubility
chemical_list: D008823:Micelles; D019301:Oleic Acid; D011374:Progesterone; D011142:Polyvinyl Alcohol; D005492:Folic Acid