Potent and selective inhibition of class II alpha-D-mannosidase activity by a bicyclic sulfonium salt.
Siriwardena
Aloysius
A
Université de Picardie Jules Verne, Faculté des Sciences, Laboratoire des Glucides, FRE 2779, 33, rue Saint Leu, 80039 Amiens, France. siriward@ccrc.uga.edu
Strachan
Heather
H
El-Daher
Samer
S
Way
Gemma
G
Winchester
Bryan
B
Glushka
John
J
Moremen
Kelley
K
Boons
Geert-Jan
GJ
D003500:Cyclization; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008247:Lysosomes / Q000187:drug effects / Q000201:enzymology; D015394:Molecular Structure; D013452:Sulfonium Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D043323:alpha-Mannosidase / Q000037:antagonists & inhibitors* / Q000145:classification / Q000378:metabolism*
D004791:Enzyme Inhibitors; D013452:Sulfonium Compounds; D043323:alpha-Mannosidase