title: Coralline hydroxyapatite reinforced with polylactide fibres in lumbar interbody implantation.
abstract: Porous hydroxyapatite HA blocks reinforced with poly-l/dl-lactide fibres were used to maintain the lumbar disc space and to start to create intercorporeal fusion in 23 growing pigs. In four pigs two emptied non adjacent disc spaces were left open. After 3, 6, 12 and 16 weeks the implanted disc blocks were studied radiologically, histologically, histomorphometrically, microradiographically, and with oxytetracycline fluorescence. In plain films slight to moderate ossification of the implanted disc spaces was detected at 12 and 16 weeks. Resorption of the implants was seen radiologically from 3 weeks and fragmentation from 12 weeks onwards. In microradiographs disintegration of the coralline inner structure started at 3 weeks. Histologically, connective tissue ingrowth was seen inside the porous structure from three weeks onwards. Small amounts of new bone were visible and connective tissue inside the implant increased from a mean of 65.6% at 3 weeks to a mean of 79.4% at 16 weeks histomorphometrically. The bone ingrowth varied from 0.7 to 1.7%. A loss of height in the implanted disc spaces was seen (p < 0.05, linear regression analysis). In control pigs the emptied disc spaces lost their height similarly. The implants used were not strong enough to maintain the lumbar disc height.
authors.affiliation: ORTON Orthopaedic Hospital of Invalid Foundation, Helsinki, Finland. mia.siitonen@hus.fi
authors.forename: P
authors.initials: P
authors.lastname: Ylinen
authors.forename: M
authors.initials: M
authors.lastname: Raekallio
authors.forename: R
authors.initials: R
authors.lastname: Taurio
authors.forename: K
authors.initials: K
authors.lastname: Vihtonen
authors.forename: S
authors.initials: S
authors.lastname: Vainionpää
authors.forename: E K
authors.initials: EK
authors.lastname: Partio
authors.forename: P
authors.initials: P
authors.lastname: Törmälä
authors.forename: P
authors.initials: P
authors.lastname: Rokkanen
mesh_terms: D000818:Animals; D002516:Ceramics / Q000737:chemistry*; D006882:Hydroxyapatites / Q000737:chemistry*; D020007:Implants, Experimental; D007403:Intervertebral Disc / Q000601:surgery; D008159:Lumbar Vertebrae / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000601:surgery*; D010012:Osteogenesis; D011091:Polyesters / Q000737:chemistry*; D011859:Radiography; D013123:Spinal Fusion / Q000295:instrumentation / Q000379:methods; D013552:Swine
chemical_list: D006882:Hydroxyapatites; D011091:Polyesters; C119955:coralline hydroxyapatite; C033616:poly(lactide)