Octanol-water partition coefficient of glucose, sucrose, and trehalose.
The octanol-water partition coefficients (P) of glucose, sucrose, and trehalose were measured at temperatures between 5 and 20 degrees C using an enzymatic method. The measured log P is compared with calculated and experimental data previously reported. In the case of trehalose, the measured log P differs considerably from the theoretically estimated values and agrees with the expected value for a disaccharide. Some methods of assessing the partition coefficients are also analyzed and it is concluded that the atom/fragment contribution method overestimates the hydrophilicity of disaccharides and, probably in a larger extension, that of trisaccharides. The knowledge of P for these sugars is valuable both for basic or applied purposes, including food and biomolecules stabilization.
Mazzobre
María F
MF
Unidad de Actividad Química, Centro Atómico Constituyentes, Comisión Nacional de Energía Atómica, Av. General Paz 1499 (1650), San Martín, Buenos Aires, Argentina. mazzobre@cnea.gov.ar
Román
María V
MV
Mourelle
Ariel Feo
AF
Corti
Horacio R
HR
D020003:1-Octanol / Q000737:chemistry*; D005947:Glucose / Q000737:chemistry*; D044367:Phase Transition; D013395:Sucrose / Q000737:chemistry*; D013696:Temperature; D014199:Trehalose / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
D014867:Water; D013395:Sucrose; D014199:Trehalose; D005947:Glucose; D020003:1-Octanol