Ambigol C and 2,4-dichlorobenzoic acid, natural products produced by the terrestrial cyanobacterium Fischerella ambigua.
The new natural products 3,5-bis(2,4-dichlorophenoxy)-2,6-dichlorophenol (ambigol C, 1), a highly chlorinated aromatic compound, and 2,4-dichlorobenzoic acid (2) were isolated from the terrestrial cyanobacterium Fischerella ambigua together with the known compounds ambigol A (3) and tjipanazole D (4). All structures were secured by extensive spectroscopic analysis (1D and 2D NMR, MS, UV, IR). Ambigol C has moderate activity against Trypanosoma rhodesiense.
Wright
Anthony D
AD
Australian Institute of Marine Science, PMB No. 3, Townsville MC, Qld 4810, Australia. a.wright@aims.gov.au
Papendorf
Olaf
O
König
Gabriele M
GM
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002227:Carbazoles / Q000737:chemistry; D002722:Chlorobenzenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002723:Chlorobenzoates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000458:Cyanobacteria / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013557:Switzerland; D014344:Trypanocidal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016833:Trypanosoma brucei rhodesiense / Q000187:drug effects
D000935:Antifungal Agents; D001713:Biphenyl Compounds; D002227:Carbazoles; D002722:Chlorobenzenes; D002723:Chlorobenzoates; D010636:Phenols; D014344:Trypanocidal Agents; C096119:ambigol A; C499912:ambigol C; C096121:tjipanazole D; C070735:2,4-dichlorobenzoic acid