Pharmacokinetic profile of tigecycline in serum and skin blister fluid of healthy subjects after multiple intravenous administrations.
The pharmacokinetics of tigecycline, when given as a 100-mg loading dose followed by 50 mg every 12 h, were determined in serum and blister fluid. The peak tigecycline concentration and half-life in serum were greater than those in blister fluid. Tigecycline penetrates into blister fluid well, with a mean penetration rate of 74%.
Sun
Heather K
HK
Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut 06102, USA.
Ong
Christine T
CT
Umer
Ambreen
A
Harper
Dawn
D
Troy
Steven
S
Nightingale
Charles H
CH
Nicolau
David P
DP
D000328:Adult; D001768:Blister / Q000378:metabolism*; D001826:Body Fluids / Q000378:metabolism; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008911:Minocycline / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood* / Q000493:pharmacokinetics*; D012867:Skin; D000078304:Tigecycline
D000078304:Tigecycline; D008911:Minocycline