[Personal exposures of benzene treated workers and a simple biological monitoring].
A simple method of biological monitoring has been developed for occupational benzene exposure. Personal benzene exposure monitoring using a passive sampler and GC/FID was carried out on 74 workers from a benzene-treated company. Their urines were collected before and after work-shift. After treatment of urine samples using solid phase extraction (SPE), trans, trans-muconic acid(t, t-MA) concentration in the elute was analysed by HPLC. Correlation between benzene exposure (X: ppm) and urinary t, t-MA concentration (Y: mg/g x creatinine) for non-smokers was Y = 0.948X + 0.586 (r = 0.798, P < 0.01) and Y = 0.885X + 0.894 (r = 0.871, P < 0.01) for smokers, respectively. The t, t-MA concentration on 1 ppm TLV exposure to benzene was estimated as 1.5 and 1.8 (mg/g creatinine) for non-smokers and smokers, respectively. These values are in agreement with some investigators. This indicates that our simple method for biological monitoring of benzene exposure can be of great service.
Yamauchi
Tsuneyuki
T
Division of Research and Analysis, Occupational Health Research and Development Center, Japan Industrial Safety and Health Association, Minato-ku, Tokyo 108-0014, Japan.
Onodera
Chika
C
Okada
Takayuki
T
Yamada
Kenichi
K
Takata
Tsutomu
T
Kadowaki
Takehiro
T
Murayama
Tomiko
T
Uchiyama
Iwao
I
Goto
Sumio
S
D000111:Acetylcysteine / Q000031:analogs & derivatives* / Q000652:urine; D001554:Benzene; D002617:Chemical Industry; D002851:Chromatography, High Pressure Liquid; D004784:Environmental Monitoring / Q000379:methods*; D006801:Humans; D008297:Male; D016273:Occupational Exposure; D012907:Smoking / Q000378:metabolism; D013011:Sorbic Acid / Q000031:analogs & derivatives* / Q000032:analysis
C005939:muconic acid; C053003:S-phenyl-N-acetylcysteine; D001554:Benzene; D000111:Acetylcysteine; D013011:Sorbic Acid