title: Pulmonary thrombosis in steroid-sensitive nephrotic syndrome.
abstract: Thrombo-embolic episodes are an uncommon but known complication of nephrotic syndrome. However, pulmonary thrombosis/thromboembolism is rare, especially in children. We describe the cases of two girls, aged 12 years, who presented with severe oedema in relapse. They had intermittent tachypnoea, and CT pulmonary angiography (CTPA) provided a less invasive and more definitive way of confirming pulmonary thrombosis/thromboembolism. They received heparin with resolution of the tachypnoea. Anticoagulation was continued for 6 months after the episode in one patient. They have been in remission for more than 1 year, and a thrombophilia screen does not indicate a predisposing tendency to the formation of clots. Pulmonary thrombosis/thromboembolism could present with subtle symptoms and needs prompt diagnosis and treatment to prevent a fatal outcome.
authors.affiliation: Department of Paediatric Nephrology, Southampton University Hospitals Trust, Tremona Road, Southampton, S016 6YD, UK. deshpp@suht.swest.nhs.uk
authors.forename: Pankaj V
authors.initials: PV
authors.lastname: Deshpande
authors.forename: Mark
authors.initials: M
authors.lastname: Griffiths
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D002648:Child; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D009404:Nephrotic Syndrome / Q000150:complications* / Q000188:drug therapy; D011655:Pulmonary Embolism / Q000150:complications* / Q000188:drug therapy; D013256:Steroids / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D013256:Steroids; D006493:Heparin