title: [Personal exposures of benzene treated workers and a simple biological monitoring].
abstract: A simple method of biological monitoring has been developed for occupational benzene exposure. Personal benzene exposure monitoring using a passive sampler and GC/FID was carried out on 74 workers from a benzene-treated company. Their urines were collected before and after work-shift. After treatment of urine samples using solid phase extraction (SPE), trans, trans-muconic acid(t, t-MA) concentration in the elute was analysed by HPLC. Correlation between benzene exposure (X: ppm) and urinary t, t-MA concentration (Y: mg/g x creatinine) for non-smokers was Y = 0.948X + 0.586 (r = 0.798, P < 0.01) and Y = 0.885X + 0.894 (r = 0.871, P < 0.01) for smokers, respectively. The t, t-MA concentration on 1 ppm TLV exposure to benzene was estimated as 1.5 and 1.8 (mg/g creatinine) for non-smokers and smokers, respectively. These values are in agreement with some investigators. This indicates that our simple method for biological monitoring of benzene exposure can be of great service.
authors.affiliation: Division of Research and Analysis, Occupational Health Research and Development Center, Japan Industrial Safety and Health Association, Minato-ku, Tokyo 108-0014, Japan.
authors.forename: Tsuneyuki
authors.initials: T
authors.lastname: Yamauchi
authors.forename: Chika
authors.initials: C
authors.lastname: Onodera
authors.forename: Takayuki
authors.initials: T
authors.lastname: Okada
authors.forename: Kenichi
authors.initials: K
authors.lastname: Yamada
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takata
authors.forename: Takehiro
authors.initials: T
authors.lastname: Kadowaki
authors.forename: Tomiko
authors.initials: T
authors.lastname: Murayama
authors.forename: Iwao
authors.initials: I
authors.lastname: Uchiyama
authors.forename: Sumio
authors.initials: S
authors.lastname: Goto
mesh_terms: D000111:Acetylcysteine / Q000031:analogs & derivatives* / Q000652:urine; D001554:Benzene; D002617:Chemical Industry; D002851:Chromatography, High Pressure Liquid; D004784:Environmental Monitoring / Q000379:methods*; D006801:Humans; D008297:Male; D016273:Occupational Exposure; D012907:Smoking / Q000378:metabolism; D013011:Sorbic Acid / Q000031:analogs & derivatives* / Q000032:analysis
chemical_list: C005939:muconic acid; C053003:S-phenyl-N-acetylcysteine; D001554:Benzene; D000111:Acetylcysteine; D013011:Sorbic Acid