title: Actometry in measuring the symptom severity of restless legs syndrome.
abstract: In a previous, controlled study we demonstrated that the general lower limb activity measured by three-channel actometry is a promising objective measure of restless legs syndrome (RLS) severity. In the present study we have further evaluated the method in measuring RLS symptom severity in an open, single-day pramipexole intervention with 15 RLS patients. Both our standardized actometric parameters (nocturnal lower limb activity and controlled rest activity) decreased significantly during the intervention in parallel with the subjectively reported relief of RLS symptoms.
authors.affiliation: Department of Psychiatry, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: K
authors.initials: K
authors.lastname: Tuisku
authors.forename: M M
authors.initials: MM
authors.lastname: Holi
authors.forename: K
authors.initials: K
authors.lastname: Wahlbeck
authors.forename: A J
authors.initials: AJ
authors.lastname: Ahlgren
authors.forename: H
authors.initials: H
authors.lastname: Lauerma
mesh_terms: D000328:Adult; D052160:Benzothiazoles; D018491:Dopamine Agonists / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018670:Monitoring, Ambulatory / Q000379:methods; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D000077487:Pramipexole; D012148:Restless Legs Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D013844:Thiazoles / Q000627:therapeutic use
chemical_list: D052160:Benzothiazoles; D018491:Dopamine Agonists; D013844:Thiazoles; D000077487:Pramipexole