title: Fluorescent dendrimers with a peptide cathepsin B cleavage site for drug delivery applications.
abstract: The synthesis of a multifunctionally equipped first generation (G1) dendrimer carrying a pentapeptide with a cathepsin[space]B cleavage site, chelating ligands for Pt2+-complexation, and a dansyl fluorescence marker is described and an investigation of its cellular uptake as well as intracellular localization by confocal fluorescence microscopy reported.
authors.affiliation: Freie Universitat Berlin, Institut fur Chemie/Biochemie, Thielallee 63, D-14195 Berlin, Germany.
authors.forename: Sabine
authors.initials: S
authors.lastname: Fuchs
authors.forename: Henning
authors.initials: H
authors.lastname: Otto
authors.forename: Stefan
authors.initials: S
authors.lastname: Jehle
authors.forename: Peter
authors.initials: P
authors.lastname: Henklein
authors.forename: A Dieter
authors.initials: AD
authors.lastname: Schluter
mesh_terms: D002401:Cathepsin B / Q000378:metabolism*; D050091:Dendrimers / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism*; D004337:Drug Carriers / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D005456:Fluorescent Dyes / Q000032:analysis / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D010446:Peptide Fragments / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D050091:Dendrimers; D004337:Drug Carriers; D005456:Fluorescent Dyes; D010446:Peptide Fragments; D002401:Cathepsin B