title: Origin of Aymaras from Bolivia and their relationship with other Amerindians according to HLA genes.
abstract: Aymara Amerindians from the Titicaca Lake Andean highlands are studied for HLA-A, HLA-B, HLA-DRB1 and HLA-DQB1 gene frequencies. Genetic distances, neighbour-joining and correspondence analyses are performed by using other Amerindian and worldwide populations (15384 chromosomes are studied). The HLA genetic profile of Aymaras is different from neighbouring and language-related Quechuas (Incas). Both Quechuas and Aymaras seem to present an HLA-DRB1*0901 high frequency, which is present in a very low frequency or absent in Mesoamericans (Mazatecans, Mayans) and most studied Amerindians. Moreover, it is observed a closer relatedness of Aymaras with Amerindians from the Amazon Basin and Chaco lowlands, compared to Quechuans.
authors.affiliation: Department of Immunology, Universidad Complutense, Madrid, Spain. aarnaiz@med.ucm.es
authors.forename: A
authors.initials: A
authors.lastname: Arnaiz-Villena
authors.forename: N
authors.initials: N
authors.lastname: Siles
authors.forename: J
authors.initials: J
authors.lastname: Moscoso
authors.forename: J
authors.initials: J
authors.lastname: Zamora
authors.forename: J I
authors.initials: JI
authors.lastname: Serrano-Vela
authors.forename: E
authors.initials: E
authors.lastname: Gomez-Casado
authors.forename: M J
authors.initials: MJ
authors.lastname: Castro
authors.forename: J
authors.initials: J
authors.lastname: Martinez-Laso
mesh_terms: D044467:American Indian or Alaska Native / Q000235:genetics*; D001838:Bolivia; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans
chemical_list: D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II