Analysis of the RB1 gene in children with retinoblastoma having residential connections to West Cumbria, England.
Six of eight cases of retinoblastoma previously identified as having a residential association with West Cumbria, England, in which the Sellafield nuclear installation is situated, were examined for the presence of a constitutional RB1 mutation. No mutations were detected, thus providing strong evidence against an environmental or occupational genotoxic effect causing germline mutations in the parents of these children.
Cowell
J K
JK
Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Morris
J A
JA
Tawn
E J
EJ
D002675:Child, Preschool; D004739:England / Q000453:epidemiology; D005260:Female; D016161:Genes, Retinoblastoma / Q000235:genetics*; D018095:Germ-Line Mutation / Q000235:genetics; D006801:Humans; D007223:Infant; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology* / Q000235:genetics*; D009688:Nuclear Reactors; D012111:Residence Characteristics; D012175:Retinoblastoma / Q000453:epidemiology* / Q000235:genetics*