title: Highly enantioselective syntheses of heterocycles via intramolecular Ir-catalyzed allylic amination and etherification.
abstract: [reaction: see text] Enantioselective Ir-catalyzed intramolecular allylic aminations and etherifications are described. Up to 97% ee was achieved using catalysts prepared by in situ activation of mixtures of phosphorus amidites and [Ir(COD)Cl]2. Sequential aminations of bis-allylic carbonates, involving an inter- followed by an intramolecular reaction, gave trans-N-benzyl-2,5-divinylpyrrolidine and trans-N-benzyl-2,6-divinylpiperidine with > or = 99% ee. New phosphorus amidites as well as improved conditions for intermolecular aminations are reported.
authors.affiliation: Organisch-Chemisches Institut der Universität Heidelberg, Im Neuenheimer Feld 270, D-69120 Heidelberg, Germany.
authors.forename: Carolin
authors.initials: C
authors.lastname: Welter
authors.forename: Axel
authors.initials: A
authors.lastname: Dahnz
authors.forename: Bernhard
authors.initials: B
authors.lastname: Brunner
authors.forename: Stephane
authors.initials: S
authors.lastname: Streiff
authors.forename: Pierre
authors.initials: P
authors.lastname: Dübon
authors.forename: Günter
authors.initials: G
authors.lastname: Helmchen