In vitro effects of spectinomycin and ceftriaxone alone or in combination with other antibiotics against Chlamydia trachomatis.
The in vitro effects of spectinomycin and ceftriaxone, alone or in combination with erythromycin, ofloxacin, and doxycycline, against Chlamydia trachomatis were investigated by the checkerboard method and compared by Ridit (reference identical unit) analysis. A combination of spectinomycin with erythromycin or doxycycline was found to be more effective than that of ceftriaxone.
Shang
Shuxian
S
National Center for STD and Leprosy control, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China.
Xia
Longqing
L
Zhong
Mingying
M
Zhang
Jinping
J
Zhao
Jianbin
J
Gong
Xiangdong
X
Mabey
David
D
Wang
Qianqiu
Q
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002443:Ceftriaxone / Q000494:pharmacology*; D002692:Chlamydia trachomatis / Q000187:drug effects*; D004318:Doxycycline / Q000494:pharmacology; D004336:Drug Antagonism; D004357:Drug Synergism; D004917:Erythromycin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000379:methods; D015242:Ofloxacin / Q000494:pharmacology; D000198:Spectinomycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D004917:Erythromycin; D002443:Ceftriaxone; D000198:Spectinomycin; D015242:Ofloxacin; D004318:Doxycycline