[Alopecia totalis, hypotension and erectile dysfunction in a 34 year old patient. Difficult clarification of a common cause].
The occurrence of both autoimmune endocrinopathies and endocrinopathies caused by other reasons is called polyglandular autoimmune syndrome (PAS-syndrome). In a 34 years old man with weakness, weight loss and erectile dysfunction we found low cortisol caused by an autoimmune adrenalitis and low testosterone caused by a hypophysitis with impaired gonadotropin secretion. Thyroid autoantibodies and islet cell autoantibodies without any hormone deficiencies were further signs of a broad endocrine autoimmune syndrome. In the following 11 years the patient developed three autoimmune disorders: paradrenal glandular insufficiency, hypogonadism caused by hypophysitis, Diabetes mellitus type 1. In the same time several non endocrine autoimmune diseases became manifest: alopecia totalis, vitiligo, retrobulbar neuritis and keratoconjunctivitis.
Hunger-Dathe
W
W
Funktionsbereich Endokrinologie und Stoffwechselerkrankungen, Klinik für Innere Medizin III, Universitätsklinikum Jena. wilgard.hunger-dathe@med.uni-jena.de
Braun
A
A
Müller
U A
UA
D000328:Adult; D000506:Alopecia Areata / Q000175:diagnosis*; D003937:Diagnosis, Differential; D007172:Erectile Dysfunction / Q000175:diagnosis*; D006801:Humans; D007022:Hypotension / Q000175:diagnosis*; D008297:Male; D016884:Polyendocrinopathies, Autoimmune / Q000175:diagnosis*