Weak palindromic consensus sequences are a common feature found at the integration target sites of many retroviruses.
Integration into the host genome is one of the hallmarks of the retroviral life cycle and is catalyzed by virus-encoded integrases. While integrase has strict sequence requirements for the viral DNA ends, target site sequences have been shown to be very diverse. We carefully examined a large number of integration target site sequences from several retroviruses, including human immunodeficiency virus type 1, simian immunodeficiency virus, murine leukemia virus, and avian sarcoma-leukosis virus, and found that a statistical palindromic consensus, centered on the virus-specific duplicated target site sequence, was a common feature at integration target sites for these retroviruses.
Wu
Xiaolin
X
Laboratory of Molecular Technology, Scientific Application International Corporation, National Cancer Institute at Frederick, 915 Toll House Ave., Frederick, MD 21701, USA.
Li
Yuan
Y
Crise
Bruce
B
Burgess
Shawn M
SM
Munroe
David J
DJ
D001483:Base Sequence; D016384:Consensus Sequence; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics*; D016679:Genome, Viral; D009690:Nucleic Acid Conformation; D012190:Retroviridae / Q000235:genetics*; D016662:Virus Integration / Q000235:genetics*
D004279:DNA, Viral