Malignant mixed Mullerian tumor of the fimbriated end of the fallopian tube: origin as an intraepithelial carcinoma.
BACKGROUND
A paucity of examples of malignant mixed Mullerian tumors (MMMT) of the fimbriated end of the fallopian tube has been reported.


METHODS
We report a first case of FIGO Stage IV primary MMMT, heterologous type, in the right fimbria of a 77-year-old woman associated with symptomatic pleural spread who succumbed with recurrent disease 12 months after resection and postoperative paclitaxel and carboplatin chemotherapy.


CONCLUSIONS
The identification of intraepithelial carcinoma in this tumor lends support to a role of the epithelial component in fimbrial MMMT histogenesis as seen for MMMT at other anatomic sites. Comparison of the clinical management of these tumors shows prolonged survival of patients whose treatment included postoperative pelvic external radiotherapy.
Gagner
Jean-Pierre
JP
Department of Pathology, Bellevue Hospital Center, New York University School of Medicine, 462 First Avenue, Room 4W35, New York, NY 10016, USA.
Mittal
Khush
K
D000368:Aged; D002278:Carcinoma in Situ / Q000473:pathology*; D005185:Fallopian Tube Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D018200:Mixed Tumor, Mullerian / Q000473:pathology*; D009367:Neoplasm Staging