Cardiac nitric oxide: emerging role for nNOS in regulating physiological function.
Emerging evidence shows that neuronal nitric oxide synthase (nNOS) plays several diverging roles in modulating cardiac function. This review examines the nitric oxide (NO) pathway and the regulatory mechanisms to which nNOS signalling is sensitive. These mechanisms are diverse and include regulation of gene expression, posttranscriptional regulation, protein trafficking, allosteric modulation of nNOS and redox modification to alter NO bioavailability once synthesised. Functionally, alteration in nNOS-NO signalling in the heart may correlate with different cardiac regulatory states. The idea of this being associated with exercise-trained states and myocardial disease is discussed.
Danson
Edward J
EJ
University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK.
Choate
Julia K
JK
Paterson
David J
DJ
D000494:Allosteric Regulation; D000818:Animals; D015971:Gene Expression Regulation, Enzymologic; D006321:Heart / Q000502:physiology*; D006801:Humans; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology*; D009569:Nitric Oxide / Q000235:genetics / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000235:genetics / Q000502:physiology*; D052248:Nitric Oxide Synthase Type I; D010084:Oxidation-Reduction; D021381:Protein Transport; D015398:Signal Transduction
D009419:Nerve Tissue Proteins; D009569:Nitric Oxide; C496320:NOS1 protein, human; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I