Anti-tumor abietane diterpenes from the cones of Sequoia sempervirens.
A new abietane, namely, 20-hydroxyferruginol (1), together with known ferruginol (2), 18-hydroxyferruginol (3), sugiol (4), and 6alpha-hydroxysugiol (5), were isolated from the cones of Sequoia sempervirens. Their structures were elucidated through spectral data. Compounds 1 and 5 strongly inhibited colon, lung, and breast human tumors and oncogene transformed cells with GI(50) 2-5 microg/mL.
Son
Kwang-Hee
KH
Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology in Korea, 52 Uendong Yoosunggu Taejeon, 305-600 Republic of Korea.
Oh
Hyun-Mi
HM
Choi
Sung-Kyu
SK
Han
Dong Cho
DC
Kwon
Byoung-Mog
BM
D045784:Abietanes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D006131:Growth Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D035261:Plant Components, Aerial / Q000737:chemistry*; D032487:Sequoia
D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic; D006131:Growth Inhibitors