title: Clinical value of different responses of serum thyroglobulin to recombinant human thyrotropin in the follow-up of patients with differentiated thyroid carcinoma.
abstract: In the present study we examined the clinical value of a differential response of thyroglobulin (Tg) concentration after recombinant human thyrotropin (rhTSH) stimulation (rhTSH Tg testing) and its correlation with (131)I uptake and whole-body scanning (rhTSH-WBS) in 104 patients who had previously undergone near-total thyroidectomy and (131)I ablation for differentiated thyroid carcinoma (DTC). rhTSH Tg testing was considered negative for rhTSH-Tg less than 0.9 ng/mL, low positive for rhTSH-Tg of 1-5 ng/mL and high positive for rhTSHTg greater than 5 ng/mL. rhTSH Tg testing was negative in 70 patients, 1 of whom had a lymph-node metastasis, but no (131)I uptake. Seven patients had low positive rhTSH Tg testing and no (131)I uptake, but 2 of these patients had cervical lymph node metastases. Twenty-seven patients had high positive rhTSH Tg testing and (131)I uptake was detected in lung, bone, or mediastinum in 11. Imaging techniques (computed tomography [CT], magnetic resonance imaging [MRI], fluorine-18 2-fluoro-2-deoxy-D-glucose-positron emission tomography [FDGPET]) documented metastatic disease in 22. In conclusion, our results suggest that any rise in rhTSH-Tg, even at low level, should raise the suspicion of persistent or recurrent DTC. Patients with rhTSH-Tg at high level should be carefully evaluated, because DTC persistence is highly probable. TSH-WBS provides little adjunctive information.
authors.affiliation: Section of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, 44100 Ferrara, Italy.
authors.forename: Alessia
authors.initials: A
authors.lastname: David
authors.forename: Annabella
authors.initials: A
authors.lastname: Blotta
authors.forename: Roberta
authors.initials: R
authors.lastname: Rossi
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Zatelli
authors.forename: Marta
authors.initials: M
authors.lastname: Bondanelli
authors.forename: Elio
authors.initials: E
authors.lastname: Roti
authors.forename: Lewis E
authors.initials: LE
authors.lastname: Braverman
authors.forename: Luciano
authors.initials: L
authors.lastname: Busutti
authors.forename: Ettore C
authors.initials: EC
authors.lastname: degli Uberti
mesh_terms: D000231:Adenocarcinoma, Papillary / Q000097:blood / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D011994:Recombinant Proteins / Q000494:pharmacology*; D012008:Recurrence; D015203:Reproducibility of Results; D013954:Thyroglobulin / Q000097:blood*; D013964:Thyroid Neoplasms / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D013965:Thyroidectomy; D013972:Thyrotropin / Q000097:blood / Q000494:pharmacology*
chemical_list: D011994:Recombinant Proteins; D013972:Thyrotropin; D013954:Thyroglobulin