Cyclic bisphosphonate therapy in osteogenesis imperfecta type V.
The clinical and radiographic features and management of a young person with recently delineated Osteogenesis Imperfecta Type V is described. A female aged 9 years presented with a history of multiple fractures since 3 years of age and bilateral dislocation of the elbows from infancy. She was commenced on a low dose frequent regimen of cyclic intravenous pamidronate, which resulted in progressive improvement in bone density, reduced fracture frequency and remission of symptoms of osteoporosis.
Fleming
F
F
Department of Clinical Genetics, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
Woodhead
H J
HJ
Briody
J N
JN
Hall
J
J
Cowell
C T
CT
Ault
J
J
Kozlowski
K
K
Sillence
D O
DO
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002648:Child; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D010013:Osteogenesis Imperfecta / Q000145:classification / Q000000981:diagnostic imaging / Q000188:drug therapy*; D000077268:Pamidronate; D011859:Radiography; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D004164:Diphosphonates; D000077268:Pamidronate