Lack of association between common polymorphisms in genes of the renin-angiotensin system and mortality after myocardial infarction.
The insertion/deletion (I/D) polymorphism in the ACE gene and the A1166C polymorphism in the AT1R gene have been associated with left ventricular remodelling and prognosis after acute myocardial infarction (AMI). We investigated whether these genetic variants associate with impaired left ventricular ejection fraction (LVEF) and increased risk for in-hospital mortality after AMI. Consecutive AMI patients were recruited on admission and were genotyped for the above-mentioned polymorphisms. The frequency of the studied genotypes did not differ significantly between deceased patients and those who survived. The LVEF did not differ among patients with or without the DD genotype (45 +/- 10 vs. 45 +/- 10%, p = 0.892) or the CC genotype (45 +/- 10 vs. 46 +/- 10%, p = 0.859). These data question the role of the studied genotypes in the pathogenesis of AMI and do not support the previously supported hypothesis that these genotypes influence prognosis after AMI.
Andrikopoulos
George K
GK
First Cardiac Department, Evangelismos Hospital, Athens, Greece. geomabuz@otenet.gr
Tzeis
Stylianos M
SM
Needham
Edward W
EW
Richter
Dimitri J
DJ
Zairis
Michalis N
MN
Gialafos
Elias J
EJ
Kardaras
Fotios G
FG
Foussas
Stefanos G
SG
Stefanadis
Christodoulos I
CI
Toutouzas
Pavlos K
PK
Mattu
Raj
R
D004251:DNA Transposable Elements / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D009203:Myocardial Infarction / Q000235:genetics* / Q000401:mortality; D010447:Peptide Hydrolases / Q000235:genetics; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics; D012084:Renin-Angiotensin System / Q000235:genetics*; D012307:Risk Factors; D017384:Sequence Deletion / Q000235:genetics; D015996:Survival Rate; D018487:Ventricular Dysfunction, Left / Q000235:genetics; D020257:Ventricular Remodeling / Q000235:genetics
D004251:DNA Transposable Elements; D044140:Receptor, Angiotensin, Type 1; D010447:Peptide Hydrolases; C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A