title: The relationship between activity and ions in patients with metal-on-metal bearing hip prostheses.
abstract: BACKGROUND
  Total hip replacements with metal-on-metal bearings are frequently implanted in young, active patients. The relationship between patient activity and cobalt and chromium ion levels has not been investigated, to our knowledge.
  
  
  METHODS
  Seven patients with well-functioning metal-on-metal bearing hip prostheses and one control subject (no implants), all with normal renal function, were monitored during a two-week-long activity protocol. Lower-extremity activity was continuously assessed with use of a computerized, two-dimensional accelerometer. During the first week, the subjects were requested to limit physical activity. The subjects then completed an hour-long treadmill test followed by a week in which they were encouraged to be as physically active as practically possible. Serum levels of cobalt and chromium ions and urine levels of chromium were assessed at ten time-points during these two weeks.
  
  
  RESULTS
  Regardless of activity, the serum ion levels for a given patient were essentially constant and no correlation was found between patient activity and serum levels of cobalt or chromium, or urine levels of chromium. A mean increase in activity of 28% during the week of high-intensity activity was associated with a mean decrease of 2.7% in the serum cobalt level and a mean increase of 2.0% in the serum chromium level. During the treadmill test, a mean increase in activity of 1621% was associated with a mean increase of 3.0% in the serum cobalt level and a mean increase of 0.8% in the serum chromium level. These results fall within the variability for the measurement accuracy of these tests.
  
  
  CONCLUSIONS
  For these patients, serum cobalt and chromium ion levels were not acutely affected by patient activity. Periodic measurements of serum ion levels could be used to monitor the tribologic (lubrication, friction, and wear) performance of a metal-on-metal bearing without adjusting for patient activity. Additional research is needed into the kinetics of ion production, transport, and excretion.
authors.affiliation: Joint Replacement Institute at Orthopaedic Hospital, 2400 South Flower Street, Los Angeles, CA 90007, USA.
authors.forename: Christian
authors.initials: C
authors.lastname: Heisel
authors.forename: Mauricio
authors.initials: M
authors.lastname: Silva
authors.forename: Anastasia K
authors.initials: AK
authors.lastname: Skipor
authors.forename: Joshua J
authors.initials: JJ
authors.lastname: Jacobs
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Schmalzried
mesh_terms: D000328:Adult; D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects; D002857:Chromium / Q000097:blood*; D003035:Cobalt / Q000097:blood*; D005080:Exercise Test / Q000009:adverse effects; D005260:Female; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D007477:Ions / Q000097:blood; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D011475:Prosthesis Failure
chemical_list: D007477:Ions; D002857:Chromium; D003035:Cobalt