Influence of Casearia esculenta root extract on glycoprotein components in streptozotocin diabetic rats.
The present study was aimed to evaluate the role of the indigenous antidiabetic medicinal plant Casearia esculenta on glycoprotein components in streptozotocin-induced diabetic rats in plasma, liver, kidney and cardiac tissues. Streptozotocin injection (50 mg/kg body weight) caused massive elevation of glycoprotein components such as hexose, hexosamine, sialic acid and fucose in plasma and tissues of diabetic control and experimental animals. Oral administration of C. esculenta root extract (200 and 300 mg/kg body weight) for 45 days significantly reverted the hexose, hexosamine, sialic acid and fucose levels to near normal values. These results suggest a normalizing effect of C. esculenta on glycoprotein components in STZ diabetic rats.
Prakasam
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A
Department of Biochemistry, Faculty of Science, Rajah Muthiah Medical College and Hospital, Annamalai University, Annamalainagar, Tamilnadu, India.
Sethupathy
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S
Pugalendi
K V
KV
D000818:Animals; D037821:Casearia / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000378:metabolism*; D005643:Fucose / Q000378:metabolism; D006023:Glycoproteins / Q000097:blood / Q000378:metabolism*; D006321:Heart / Q000187:drug effects; D006601:Hexoses / Q000097:blood; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D019158:N-Acetylneuraminic Acid / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
D006023:Glycoproteins; D006601:Hexoses; D010936:Plant Extracts; D005643:Fucose; D019158:N-Acetylneuraminic Acid