Stability and compatibility of binary mixtures of morphine hydrochloride with hyoscine-n-butyl bromide.
The aim of this study was to determine the compatibility and stability of morphine hydrochloride and hyoscine-N-butyl bromide combined in solution at three different concentrations and stored in polypropylene syringes at 4 degrees C and 25 degrees C over a period of 15 days. The doses assayed were 20, 60 and 120 mg/day for morphine hydrochloride and 40, 60 and 80 mg/day for hyoscine-N-butyl bromide. These dose ranges were chosen according to daily practice. At both temperatures, all mixtures can be considered as physically compatible since no evidence of incompatibility-that is precipitation, turbidity, colour change or opacity and gas production-were observed. After 15 days of storage, the percentages of hyoscine-N-butyl bromide remaining in the drug mixtures tested ranged between 96.07% and 92.23%. At the end of the study, the percentages of morphine hydrochloride remaining in the drug mixtures were 100% at both temperatures.
Barcia
Emilia
E
Department of Pharmaceutics, School of Pharmacy, University Complutense of Madrid, Ciudad Universitaria s/n, 28040, Madrid, Spain. ebarcia@farm.ucm.es
Reyes
Rodrigo
R
Azuara
Maria Luz
ML
Sánchez
Yolanda
Y
Negro
Sofía
S
D002086:Butylscopolammonium Bromide / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations; D004355:Drug Stability; D004356:Drug Storage / Q000379:methods; D006801:Humans; D009020:Morphine / Q000737:chemistry*; D013030:Spain
D004338:Drug Combinations; D002086:Butylscopolammonium Bromide; D009020:Morphine