title: Progressive supranuclear palsy-like phenotype associated with bilateral hypoxic-ischemic striopallidal lesions.
abstract: A progressive supranuclear palsy (PSP)-like syndrome due to vascular or anoxic brain insult is rare. We describe a 65-year-old man with a progressive PSP-like phenotype associated with hypoxic-ischemic bilateral striopallidal lesions, secondary to rupture of and subsequent surgery for a thoracic aortic aneurysm. After early extrapyramidal features, 10 months later he started to fall, and developed levator inhibition. A supranuclear gaze palsy for downgaze was documented 5.5 years after the insult.
authors.affiliation: National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.
authors.forename: Hee Tae
authors.initials: HT
authors.lastname: Kim
authors.forename: Simon
authors.initials: S
authors.lastname: Shields
authors.forename: Kailash P
authors.initials: KP
authors.lastname: Bhatia
authors.forename: Niall
authors.initials: N
authors.lastname: Quinn
mesh_terms: D000368:Aged; D003342:Corpus Striatum / Q000473:pathology*; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000150:complications* / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D013494:Supranuclear Palsy, Progressive / Q000150:complications* / Q000473:pathology*