Inhibitory effects of stilbenes in Sophora moorcroftiana BENTH ex BAKER on copper ion-induced protein oxidative modification of mouse brain homogenate in vitro.
We present the results of an in vitro investigation of the inhibitory effects of sophorastilbene A and (+)-alpha-viniferin isolated from Sophora moorcroftiana BENTH ex BAKER on copper ion-induced protein oxidative modification. They inhibited copper-induced protein oxidative modification. The order of these stilbenes and mannitol as a hydroxyl radical scavenger was sophorastilbene A > (+)-alpha-viniferin > mannitol.
Toda
Shizuo
S
Department of Pharmaceutical Science, Kansai College of Oriental Medicine, 2-11-1 Wakaba, Kumatori, Sen-nan, Osaka 590-0482, Japan. toda@kansai.ac.jp
Shirataki
Yoshiaki
Y
D000818:Animals; D001572:Benzofurans / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects*; D003300:Copper; D004305:Dose-Response Relationship, Drug; D008297:Male; D008353:Mannitol / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D008815:Mice, Inbred Strains; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D029909:Sophora; D013267:Stilbenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
D001572:Benzofurans; D010936:Plant Extracts; D013267:Stilbenes; D008353:Mannitol; C064176:alpha-viniferin; D003300:Copper