title: Bioactive asterosaponins from the starfish Culcita novaeguineae.
abstract: Two new sulfated steroidal pentaglycosides (asterosaponins), novaeguinosides I (2) and II (3), along with the known regularoside B (1) were isolated from the starfish Culcita novaeguineae. Their structures were elucidated by extensive NMR techniques as well as chemical evidence. The new asterosaponins showed marginal in vitro cytotoxicity against two human tumor cell lines.
authors.affiliation: Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, Shanghai 200433, People's Republic of China. tanghaifeng71@126.com
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Tang
authors.forename: Yang-Hua
authors.initials: YH
authors.lastname: Yi
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Peng
authors.initials: P
authors.lastname: Sun
authors.forename: San-Qi
authors.initials: SQ
authors.lastname: Zhang
authors.forename: Yue-Ping
authors.initials: YP
authors.lastname: Zhao
mesh_terms: D000818:Animals; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013215:Starfish / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D012503:Saponins; C499565:novaeguinoside I; C499567:novaeguinoside II; C499568:regularoside B