Cycloruthenated primary and secondary amines as efficient catalyst precursors for asymmetric transfer hydrogenation.
[reaction: see text] Ruthenacycles obtained by cyclometalation of enantiopure aromatic primary or secondary amines with [(eta6-benzene)RuCl2]2 or with [(eta6-p-cymene)RuCl2]2 are efficient catalysts for asymmetric transfer hydrogenation (TOF up to 190 h(-1) at room temperature). Enantioselectivities in the transfer hydrogenation of acetophenone ranged from 38% to 89%. It is possible to prepare the catalysts in situ, which allows the use of high throughput experimentation.
Sortais
Jean-Baptiste
JB
CNRS, UMR 7513, Laboratoire de Synthèses Métallo-Induites, Université Louis Pasteur, 4 rue Blaise Pascal, 67000 Strasbourg, France.
Ritleng
Vincent
V
Voelklin
Adeline
A
Holuigue
Alexandre
A
Smail
Hakima
H
Barloy
Laurent
L
Sirlin
Claude
C
Verzijl
Gerard K M
GK
Boogers
Jeroen A F
JA
de Vries
André H M
AH
de Vries
Johannes G
JG
Pfeffer
Michel
M