Disseminated granuloma annulare--treatment with fumaric acid esters.
BACKGROUND
The therapy of disseminated granuloma annulare has often limited success. Treatment of granuloma annulare with fumaric acid esters (FAE) has recently been reported to be effective in 2 patients.


OBJECTIVE
To assess the efficacy of a systemic therapy with FAE in consecutive patients with disseminated granuloma annulare.


METHODS
Eight patients with disseminated granuloma annulare were treated with FAE in tablet form according to the standard therapy regimen used in psoriasis. The colour and the elevation of the skin lesions were assessed by a visual analogue scale before and after therapy.


RESULTS
Systemic therapy with FAE induced a significant clinical improvement in elevation and colour of skin lesions, with remission in 3 and partial remission in 4 patients. One patient remained unchanged. Side-effects associated with the therapy were seen in 6 patients.


CONCLUSIONS
Systemic therapy with FAE can be effective in patients suffering from disseminated forms of granuloma annulare, but side-effects of FAE have to be taken into consideration.
Eberlein-König
B
B
Division Environmental Dermatology and Allergology GSF/TUM, Neuherberg-Munich, Germany. Eberlein-Koenig@lrz.tu-muenchen.de
Mempel
M
M
Stahlecker
J
J
Forer
I
I
Ring
J
J
Abeck
D
D
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000069462:Dimethyl Fumarate; D005260:Female; D005650:Fumarates / Q000008:administration & dosage / Q000627:therapeutic use*; D016460:Granuloma Annulare / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D012720:Severity of Illness Index; D016896:Treatment Outcome
D003879:Dermatologic Agents; D005650:Fumarates; D000069462:Dimethyl Fumarate