[Effect of some imidazole-4,5-dicarboxylic acid derivatives on the activity of N-methyl-D-aspartate (NMDA) receptors].
The results of experiments on mice showed that some imidazole-4,5-dicarboxylic acid derivatives injected into lateral cerebral ventricles produce a dose-dependent convulsant or anticonvulsant effects, that is, possess the properties of partial NMDA receptor agonists. The most promising partial NMDA receptor agonist selected for further investigation is 2-propylimidazole-4,5-dicarboxylic acid.
Efremov
O M
OM
Aleksandrova
I Ia
IIa
Kulikov
S V
SV
Losev
N A
NA
Piotrovskiĭ
L B
LB
D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage*; D002531:Cerebellum / Q000378:metabolism*; D003292:Convulsants / Q000008:administration & dosage*; D003998:Dicarboxylic Acids / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D007093:Imidazoles / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists* / Q000378:metabolism
D000927:Anticonvulsants; D003292:Convulsants; D003998:Dicarboxylic Acids; D007093:Imidazoles; D016194:Receptors, N-Methyl-D-Aspartate