title: Detection of Tc-99m labelled albumin particles in the Fallopian tubes after intraperitoneal deposition.
abstract: OBJECTIVE
  To study the Fallopian tube uptake of intra-abdominal albumin particles.
  
  
  METHODS
  Six healthy women volunteered for ultrasound guided deposition of Tc-99m labelled albumin particles into the pouch of Douglas, before undergoing sterilisation by salpingectomy.
  
  
  RESULTS
  On gamma camera images radioactivity spread evenly over the parietal peritoneum. Autoradiography of the Fallopian tubes showed radioactive "hot spots" on the inner tubal surface. A rapid increase in blood radioactivity stabilised after 2-3 h while radioactivity remained high in the peritoneal cavity. Cervical mucus showed a significant radioactivity.
  
  
  CONCLUSIONS
  Autoradiography strongly indicated that Tc-99m labelled particles deposited into the pouch of Douglas were transported to the Fallopian tubes. The small uptake of radioactivity identified in blood was most likely due to a rapid diffusion of free Tc-99m pertechnetate from the peritoneal cavity. The radioactivity identified in cervical mucus could be pertechnetate or labelled albumin particles or a combination of both. Future development of the present technique may be used for fertility investigation.
authors.affiliation: Division for Obstetrics and Gynaecology, Department of Woman and Child Health, Karolinska Hospital, S-17176 Stockholm, Sweden.
authors.forename: Steffan
authors.initials: S
authors.lastname: Lundberg
authors.forename: Kjell
authors.initials: K
authors.lastname: Wånggren
authors.forename: Harald
authors.initials: H
authors.lastname: Almström
authors.forename: Hans-Jerker
authors.initials: HJ
authors.lastname: Lundberg
authors.forename: Per-Erik
authors.initials: PE
authors.lastname: Asard
authors.forename: Håkan
authors.initials: H
authors.lastname: Wramsby
mesh_terms: D000328:Adult; D001345:Autoradiography; D001692:Biological Transport; D002582:Cervix Mucus / Q000378:metabolism; D004312:Douglas' Pouch; D005187:Fallopian Tubes / Q000378:metabolism*; D005260:Female; D006801:Humans; D007700:Kinetics; D010537:Peritoneum / Q000378:metabolism*; D013246:Sterilization, Tubal; D013668:Technetium Tc 99m Aggregated Albumin / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D013668:Technetium Tc 99m Aggregated Albumin