[Effect of ethanol and 4-methylpyrazole on the immunotoxicity of ethylene glycol].
The results of experiments on Wistar rats showed that acute poisoning with 1.0 LD50 of ethylene glycol decreased the nonspecific resistance of the organism (manifested by increased lethality caused by experimental infection, decreased average lethal dose of E. coli, and decreased mean effective lifetime of experimental animals) and reduced the antibody formation to predominantly a thymus-dependent antigen, natural and antibody-dependent cell cytotoxicity, and delayed type hypersensitivity reaction. 4-Methylpyrazole and (to a greater extent) ethanol potentiated the immunotoxic action of ethylene glycol.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects* / Q000276:immunology; D002492:Central Nervous System Depressants / Q000008:administration & dosage*; D004357:Drug Synergism; D004927:Escherichia coli Infections / Q000276:immunology*; D000431:Ethanol / Q000008:administration & dosage*; D019855:Ethylene Glycol / Q000633:toxicity*; D000077604:Fomepizole; D006968:Hypersensitivity, Delayed / Q000276:immunology; D011720:Pyrazoles / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar
D002492:Central Nervous System Depressants; D011720:Pyrazoles; D000431:Ethanol; D000077604:Fomepizole; D019855:Ethylene Glycol