Neoadjuvant combined chemotherapy followed by external whole pelvic irradiation in two cases of primary extranodal non-Hodgkin's lymphoma of the uterine cervix.
BACKGROUND
Primary extranodal lymphomas of the genital tract are rare.


METHODS
As there is no current consensus in its management, we present two further cases and their treatment with neoadjuvant chemotherapy, followed by radiation therapy. A radical hysterectomy with bilateral pelvic lymphadenectomy was performed after primary treatment in one case. Clinical response was complete in both cases and pathological response was documented in one.


CONCLUSIONS
Complete response of these lymphoid neoplasms can be achieved by neoadjuvant chemotherapy followed by external irradiation.
Heredia
Fernando
F
Instituto Clinico Oncologico de la Fundacion Arturo Lopez Perez, Santiago de Chile, Chile. herediaf@falp.org
Bravo
Marco
M
Pierotic
Mateo
M
Majlis
Alejandro
A
Carmona
Leonardo
L
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D008727:Methotrexate / Q000008:administration & dosage; D020360:Neoadjuvant Therapy; D011241:Prednisone / Q000008:administration & dosage; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D002955:Leucovorin; D011241:Prednisone; D008727:Methotrexate