Role of anti-beta-glucan antibody in host defense against fungi.
We have recently detected an anti-beta-glucan antibody in normal human and normal mouse sera. The anti-beta-glucan antibody showed reactivity to pathogenic fungal Aspergillus and Candida cell wall glucan. Anti-beta-glucan antibody could bind whole Candida cells. It also enhanced the candidacidal activity of macrophages in vitro. The anti-beta-glucan antibody titer of DBA/2 mice intravenously administered either Candida or Aspergillus solubilized cell wall beta-glucan decreased remarkably dependent on dose. Moreover, in deep mycosis patients, the anti-beta-glucan antibody titer decreased, and this change correlated with clinical symptoms and other parameters such as C-reactive protein. It was suggested that the anti-beta-glucan antibody formed an antigen-antibody complex and participated in the immune response as a molecule recognizing pathogenic fungi.
Ishibashi
Ken-Ichi
K
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Yoshida
Masaharu
M
Nakabayashi
Iwao
I
Shinohara
Hiroyasu
H
Miura
Noriko N
NN
Adachi
Yoshiyuki
Y
Ohno
Naohito
N
D000818:Animals; D000908:Antibodies, Fungal / Q000097:blood*; D000918:Antibody Specificity; D000936:Antigen-Antibody Complex; D000946:Antigens, Fungal; D001228:Aspergillosis / Q000276:immunology / Q000382:microbiology; D001230:Aspergillus / Q000276:immunology* / Q000472:pathogenicity; D002175:Candida / Q000276:immunology* / Q000472:pathogenicity; D002177:Candidiasis / Q000276:immunology / Q000382:microbiology; D002473:Cell Wall / Q000276:immunology; D005260:Female; D006801:Humans; D007113:Immunity, Innate; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D047071:beta-Glucans / Q000276:immunology*
D000908:Antibodies, Fungal; D000936:Antigen-Antibody Complex; D000946:Antigens, Fungal; D047071:beta-Glucans