Semi-synthesis and biological evaluation of analogues of UK-2A, a novel antifungal antibiotic from Streptomyces sp. 517-02.
Several analogues of UK-2A, a novel antifungal antibiotic isolated from Streptomyces sp. 517-02, were semi-synthesized for structure-activity studies. In vitro antifungal activities of these compounds against Saccharomyces cerevisiae IFO 0203 were evaluated by the conventional paper disk method. Several derivatives exhibited growth inhibitory activity similar to UK-2A.
Usuki
Yoshinosuke
Y
Department of Material Science, Graduate School of Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan. usuki@sci.osaka-cu.ac.jp <usuki@sci.osaka-cu.ac.jp>
Mitomo
Koichi
K
Adachi
Noriko
N
Ping
Xu
X
Fujita
Ken-Ichi
K
Sakanaka
Osamu
O
Iinuma
Katsuharu
K
Iio
Hideo
H
Taniguchi
Makoto
M
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D007783:Lactones / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000254:growth & development; D013302:Streptomyces / Q000737:chemistry*
D000935:Antifungal Agents; D007783:Lactones; D011725:Pyridines; C101439:UK 2A