Loxoprofen inhibits facilitated micturition reflex induced by acetic acid urinary bladder infusion of the rats.
Prostaglandins (PGs) are well known as one of the chemical mediators of inflammation. Nonsteroidal anti-inflammatory drugs (NSAIDs), PG synthesis inhibitors, are used for anti-nociception and/or anti-inflammation. We examine the effect of loxoprofen, an NSAID, on micturiton in acetic acid-induced bladder inflammation of the rats. In cystometrogram study with saline infusion into the urinary bladder, loxoprofen did not alter the interval of bladder contraction (IC, 107% of the control). IC was shortened by acetic acid infusion (65% of the control) and loxoprofen prolonged the IC (162% of acetic acid infused period). This prolonged IC was approximately same as the control. Loxoprofen did not alter the threshold pressure and the maximal voiding pressure. These data suggest that PGE2 might not play a part of normal micturition and may play a part of the micturition reflex during acetic acid infusion. That is, loxoprofen might be useful for pathological hyperreflex of the micturition.
Shinozaki
Sachiyo
S
Department of Neurophysiology, Akita University School of Medicine, Akita, Japan.
Saito
Motoaki
M
Kawatani
Masahito
M
D019342:Acetic Acid / Q000633:toxicity; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D003556:Cystitis / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology; D015232:Dinoprostone / Q000502:physiology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D010666:Phenylpropionates / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012018:Reflex / Q000187:drug effects; D001743:Urinary Bladder / Q000187:drug effects* / Q000502:physiology*; D014554:Urination / Q000187:drug effects* / Q000502:physiology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010666:Phenylpropionates; C040656:loxoprofen; D015232:Dinoprostone; D019342:Acetic Acid