Selective detection of saxitoxin over tetrodotoxin using acridinylmethyl crown ether chemosensor.
At pH 7.1, saxitoxin decomposes to produce a trace impurity that can interfere with fluorescence sensing when using irradiation wavelengths near 325 nm. The fluorophore acridine is found to be a suitable component of arylmethyl crown ether chemosensors for the fluorescent detection of saxitoxin. These sensors are selective for the detection of saxitoxin over tetrodotoxin.
Gawley
Robert E
RE
Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701, USA. bgawley@uark.edu
Shanmugasundaram
Muthian
M
Thorne
John B
JB
Tarkka
Richard M
RM
D015374:Biosensing Techniques / Q000379:methods*; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D002850:Chromatography, Gel; D003374:Coumarins / Q000737:chemistry; D043844:Crown Ethers / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D011485:Protein Binding; D012530:Saxitoxin / Q000032:analysis* / Q000737:chemistry; D013779:Tetrodotoxin / Q000032:analysis* / Q000737:chemistry
D003374:Coumarins; D043844:Crown Ethers; D012530:Saxitoxin; D013779:Tetrodotoxin; C030123:coumarin