[Tyramine and serotonin syndromes. Pharmacological, medical and legal remarks].
The tyramine syndrome and the serotonin syndrome are a complex of signs and symptoms that are thought to be largely attributable to drug - drug interactions or drug - food interactions that enhances norepinephrine o serotonin activity. This article reviews: pharmacological basis of those syndromes; clinical features; forbidden foods, drug-drug interactions, and treatment options. Finally a set of legal recommendations are proposed to avoid liability litigations.
Toro-Martínez
Esteban
E
Facultad de Medicina, Universidad de Buenos Aires, Argentina. etoro@fibertel.com.ar
D000928:Antidepressive Agents / Q000009:adverse effects*; D004347:Drug Interactions; D006801:Humans; D016365:Liability, Legal; D020258:Neurotoxicity Syndromes / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D017410:Practice Guidelines as Topic; D012701:Serotonin / Q000502:physiology*; D014439:Tyramine / Q000502:physiology*
D000928:Antidepressive Agents; D012701:Serotonin; D014439:Tyramine