title: Hemiterpene glucosides with anti-platelet aggregation activities from Ilex pubescens.
abstract: Two new hemiterpene glucosides named pubescenosides A and B were isolated from the root of Ilex pubescens. Their structures were elucidated on the basis of spectroscopic and chemical evidence as 2-(trans-caffeoyloxy)methyl-3-hydroxy-1-butene-4-O-beta-D-glucopyranoside and 2-hydroxymethyl-3-caffeoyloxy-1-butene-4-O-beta-D-glucopyranoside, respectively. Pharmacological investigation on pubescenosides A and B indicated that both possess potent anti-platelet aggregation activities.
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, People's Republic of China.
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Jiang
authors.forename: Jing-Rong
authors.initials: JR
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Zhong-Qiu
authors.initials: ZQ
authors.lastname: Liu
authors.forename: Ka-Yee
authors.initials: KY
authors.lastname: Chau
authors.forename: Chi
authors.initials: C
authors.lastname: Zhao
authors.forename: Liang
authors.initials: L
authors.lastname: Liu
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045782:Hemiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D030017:Ilex / Q000737:chemistry*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D010974:Platelet Aggregation / Q000187:drug effects*; D010979:Platelet Function Tests; D051381:Rats
chemical_list: D004365:Drugs, Chinese Herbal; D005960:Glucosides; D045782:Hemiterpenes; C499932:pubescenoside A; C499933:pubescenoside B