Synthesis and antibacterial activity of adamantyl substituted pyrimidines.
A series of new S-substituted 6-adamantylpyrimidines were prepared by alkylation on the thiol groups in 6-adamant-1-yl-2-methyl-3H-pyrimidine-4-thione and 6-adamant-1-yl-2-thioxo-2,3-dihydro-1H-pirymidin-4-one, respectively. Then, these compounds were tested against several bacterial strains as well as fungi.
Orzeszko
Barbara
B
Warsaw University of Technology, Faculty of Chemistry, 00-662 Warsaw.
Laudy
Agnieszka Ewa
AE
Starościak
Bohdan Jerzy
BJ
Orzeszko
Andrzej
A
Kazimierczuk
Zygmunt
Z
D000218:Adamantane / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D011743:Pyrimidines; D000218:Adamantane