Use of perfusion parameters in predicting outcomes of machine-preserved kidneys.
Perfusion parameters (PP) and early transplant outcome data from 332 consecutive ECD type kidneys machine preserved on the Waters RM-3 apparatus were reviewed and analyzed to examine the validity of using suboptimal PPs (renal resistance of .41-.60) as a criterion for discarding kidneys. Overall discard rate was 23.5%, with 55% of these having "poor" PP as part of reason for discard. PP analysis after 4 hours on the RM-3 is presented. This encompasses 280 kidneys with renal resistance </= .60. Sixty-six kidneys were discarded (23.5%). Of the 214 transplanted kidneys, 146 had immediate function (IF; 68%), 63 had delayed function (DGF; 29%), and 5 never functioned (PNF; 2%). Of the 30 transplanted kidneys with renal resistance .40 to .60, 16 (53%) had IF versus 58% in kidneys with renal resistance </= .40 (P = .125). Two of the five PNF kidney had renal resistance > .40. The PP-related discard rate in the renal resistance .41 to .60 kidneys was 51% versus 17% in the renal resistance </= .40 (P </= .01). Based on our observations kidneys with renal resistance </= .60 should not be discarded strictly based on "suboptimal perfusion parameters." This presents an opportunity for a decrease in discard rates of ECD kidneys.
Mozes
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MF
Gift of Hope Organ and Tissue Donor Network, Elmhurst, Illinois 60126, USA. mmozes@giftofhope.org
Skolek
R B
RB
Korf
B C
BC
D006801:Humans; D007668:Kidney; D016030:Kidney Transplantation / Q000379:methods* / Q000502:physiology*; D008875:Middle Aged; D009926:Organ Preservation / Q000379:methods*; D018579:Patient Selection; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D016896:Treatment Outcome