title: The effect of incorporating vessel compliance in a computational model of blood flow in a total cavopulmonary connection (TCPC) with caval centerline offset.
abstract: BACKGROUND
  The total cavopulmonary connection (TCPC), a palliative correction for congenital defects of the right heart, is based on the corrective technique developed by Fontan and Baudet. Research into the TCPC has primarily focused on reducing power loss through the connection as a means to improve patient longevity and quality of life. The goal of our study is to investigate the efficacy of including a caval offset on the hemodynamics and, ultimately, power loss of a connection. As well, we will quantify the effect of vessel wall compliance on these factors and, in addition, the distribution of hepatic blood to the lungs.
  
  
  METHODS
  We employed a computational fluid dynamic model of blood flow in the TCPC that includes both the non-Newtonian shear thinning characteristics of blood and the nonlinear compliance of vessel tissue.
  
  
  RESULTS
  Power loss in the rigid-walled simulations decayed exponentially as caval offset increased. The compliant-walled results, however, showed that after an initial substantial decrease in power loss for offsets up to half the caval diameter, power loss increased slightly again. We also found only minimal mixing in both simulations of all offset models.
  
  
  CONCLUSIONS
  The increase in power loss beyond an offset of half the caval diameter was due to an increase in the kinetic contribution. Reduced caval flow mixing, on the other hand, was due to the formation of a pressure head in the offset region which acts as a barrier to flow.
authors.affiliation: Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. masters@bme.unc.edu
authors.forename: J C
authors.initials: JC
authors.lastname: Masters
authors.forename: M
authors.initials: M
authors.lastname: Ketner
authors.forename: M S
authors.initials: MS
authors.lastname: Bleiweis
authors.forename: M
authors.initials: M
authors.lastname: Mill
authors.forename: A
authors.initials: A
authors.lastname: Yoganathan
authors.forename: C L
authors.initials: CL
authors.lastname: Lucas
mesh_terms: D001783:Blood Flow Velocity; D001794:Blood Pressure; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D004548:Elasticity; D018610:Heart Bypass, Right / Q000379:methods*; D006330:Heart Defects, Congenital / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D008955:Models, Cardiovascular; D011651:Pulmonary Artery / Q000503:physiopathology* / Q000601:surgery*; D033081:Shear Strength; D025321:Surgery, Computer-Assisted / Q000379:methods; D014655:Vascular Resistance; D014684:Venae Cavae / Q000503:physiopathology* / Q000601:surgery*