title: [Antihypoxant activity in a series of 2-aminothiazole homologs].
abstract: The antihypoxic activity of a series of 2-aminothiazole homologs and the related N-syccinamic acids was studied on four hypoxia models. All 2-aminothiazoles possess antihypoxant properties, which increase with the complexity of the molecular structure. The attachment of a succinic acid fragment at the amino group reduced toxicity, but also decreased the antihypoxant activity of drugs.
authors.forename: V V
authors.initials: VV
authors.lastname: Marysheva
authors.forename: P D
authors.initials: PD
authors.lastname: Shabanov
mesh_terms: D000577:Amides / Q000008:administration & dosage; D000818:Animals; D000860:Hypoxia / Q000188:drug therapy*; D008297:Male; D051379:Mice; D015394:Molecular Structure; D051381:Rats; D013329:Structure-Activity Relationship; D013386:Succinates; D013844:Thiazoles / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000577:Amides; D013386:Succinates; D013844:Thiazoles; C004483:2-aminothiazole; C011116:succinamide