title: Differential effects of propofol on cerebrovascular carbon dioxide reactivity in elderly versus young subjects.
abstract: OBJECTIVE
  To examine the age-related difference between elderly and young patients in the effect of propofol on cerebrovascular carbon dioxide (CO(2)) reactivity.
  
  
  METHODS
  Prospective controlled study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Elderly (older than 70 years, n = 13) and young patients (younger than 25 years, n = 13) scheduled for elective orthopedic surgery.
  
  
  METHODS
  After induction of anesthesia, a 2.5-MHz pulsed transcranial Doppler probe was attached to the patient's head at the right temporal window, from which mean blood flow velocity of the middle cerebral artery was measured continuously.
  
  
  METHODS
  After obtaining baseline values of velocity of the middle cerebral artery, arterial blood gases, and cardiovascular hemodynamics, end-tidal CO(2) was decreased by increasing the ventilatory frequency by 2 to 5 breaths per minute. Measurements were repeated when end-tidal CO(2) decreased and remained stable for 5 to 10 minutes. Cerebrovascular CO(2) reactivity, at propofol doses of 5 and 10 mg/kg/h, was measured.
  
  
  RESULTS
  No significant differences were observed between the 2 groups in baseline absolute and relative CO(2) reactivity. However, there were significant differences between the 2 groups in absolute or relative CO(2) reactivity at a propofol dosage of 5 mg/kg/h. (Absolute CO(2) reactivity in young patients: 2.1 +/- 0.8 cm/s/mm Hg; elderly: 1.6 +/- 0.4* cm/s/mm Hg. Relative CO(2) reactivity in young patients: 7.4% +/- 1.6%/mm Hg; in the elderly: 6.5% +/- 0.9%*/mm Hg; unpaired t test, *P < .05). In contrast, there were no significant differences between the 2 groups in terms of absolute or relative CO(2) reactivity at a propofol dosage of 10 mg/kg/h.
  
  
  CONCLUSIONS
  Cerebrovascular CO(2) reactivity in elderly patients was lower than that in young patients at a propofol dosage of 5 mg/kg/h.
authors.affiliation: Department of Intensive Care, Graduate School of Medicine, Gunma University, Gunma 371-8511, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hinohara
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kadoi
authors.forename: Ken-ichiro
authors.initials: K
authors.lastname: Takahashi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Saito
authors.forename: Fumio
authors.initials: F
authors.lastname: Goto
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D015742:Propofol / Q000493:pharmacokinetics / Q000494:pharmacology*; D011446:Prospective Studies; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D002245:Carbon Dioxide; D015742:Propofol