title: Protective effect of epigallocatechin gallate and esculetin on oxidative DNA damage induced by psoralen plus ultraviolet-A therapy.
abstract: We examined antioxidants exhibiting no effects on DNA cross-linking, which is the basis of psoralen and ultraviolet-A therapy for skin diseases, and suppressing oxidative DNA damage incidental to the therapy. Epigallocatechin gallate and esculetin effectively suppressed oxidative DNA damage with little effect on the formation of DNA cross-linking. These antioxidants might be useful in suppressing the adverse reaction induced by this therapy.
authors.affiliation: Redox Regulation Research Group, Tokyo Metropolitan Institute of Gerontology, Japan.
authors.forename: Shoichi
authors.initials: S
authors.lastname: Tahara
authors.forename: Naomichi
authors.initials: N
authors.lastname: Baba
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Matsuo
authors.forename: Takao
authors.initials: T
authors.lastname: Kaneko
mesh_terms: D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004249:DNA Damage; D005363:Ficusin / Q000494:pharmacology*; D018384:Oxidative Stress; D011701:PUVA Therapy; D014468:Umbelliferones / Q000494:pharmacology*
chemical_list: D014468:Umbelliferones; D002392:Catechin; C045651:epigallocatechin gallate; D005363:Ficusin; C007628:esculetin