title: Hyaluronan chain conformation and dynamics.
abstract: An overview of the present state of research in the field of hyaluronan chain conformational aspects is presented. The relationship between structure and dynamics are illustrated for a series of hyaluronan oligomers. Conformational characteristics of hyaluronan chains are discussed, together with the dynamic chain patterns, evaluated by using a theoretical approach to diffusive polymer dynamics. The dependence of correlation times and NMR relaxation parameters from the chain dimension are investigated. Topological features and dimensional properties are related to the structural determinants by using classical computational methods of molecular mechanics and Monte Carlo simulation.
authors.affiliation: Department of Biochemistry, Biophysics and Macromolecular Chemistry, UdR INSTM, University of Trieste, I-34127 Trieste, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Furlan
authors.forename: Giovanni
authors.initials: G
authors.lastname: La Penna
authors.forename: Angelo
authors.initials: A
authors.lastname: Perico
authors.forename: Attilio
authors.initials: A
authors.lastname: Cesàro
mesh_terms: D002236:Carbohydrate Conformation; D006820:Hyaluronic Acid / Q000737:chemistry*; D009010:Monte Carlo Method; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D006820:Hyaluronic Acid