A new flavone glycoside and other constituents from Carduus crispus.
A new flavone glycoside, chrysoeriol 7-O-(2"-O-6'''-O-acetyl-beta-D-glucopyranosyl-beta-D-glucopyranoside (1), along with fourteen known compounds 2-15 were isolated from the whole plant of Carduus crispus Linn. Their structures were established on the basis of spectroscopic methods and chemical evidences. The antitumour activity of compound 1, 4 and 5 was tested. Compound 4 exhibited significant antitumour activity against HO-8901 (human ovarian neoplasm) cells.
Xie
Wei-Dong
WD
Department of Chemistry, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, People's Republic of China.
Li
Ping-Lin
PL
Jia
Zhong-Jian
ZJ
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D031177:Carduus / Q000737:chemistry*; D045744:Cell Line, Tumor; D002855:Chromatography, Thin Layer; D004354:Drug Screening Assays, Antitumor; D005260:Female; D047309:Flavones / Q000138:chemical synthesis* / Q000494:pharmacology; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D006868:Hydrolysis; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D010051:Ovarian Neoplasms / Q000188:drug therapy; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet
D000972:Antineoplastic Agents, Phytogenic; D047309:Flavones; D006027:Glycosides; D007202:Indicators and Reagents; C499899:chrysoeriol 7-O-(2''-O-6'''-O-acetyl-beta-D-glucopyranosyl-beta-D-glucopyranoside)