title: Features of the iridocorneal endothelial syndrome on confocal microscopy.
abstract: OBJECTIVE
  To present a subtle case of iridocorneal endothelial (ICE) syndrome and discuss the utility of in vivo confocal microscopy in the evaluation of this disorder. Previous reports of the confocal microscopic features of ICE syndrome are reviewed.
  
  
  METHODS
  A 32-year-old man presented with decreased vision and halos. Slit-lamp biomicroscopy and in vivo confocal microscopy were used to evaluate the etiology of his complaints. Clinical photographs and confocal micrographs were analyzed.
  
  
  RESULTS
  In vivo confocal microscopy revealed marked asymmetry between the right and left corneal endothelial layers with pleomorphic epithelioid cells on the right, some with hyperreflective nuclei. A transition between cells with uniform appearance and dark nuclei and a highly irregular cellular arrangement with hyperreflective nuclei was present.
  
  
  CONCLUSIONS
  This report supports the clinical utility of in vivo confocal microscopy in the evaluation of ICE syndrome. It demonstrates that the histopathologic features of ICE syndrome on scanning electron microscopy may be shown clinically using high-resolution confocal microscopy.
authors.affiliation: Cornea and Anterior Segment Service, The Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD 21287, USA.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Garibaldi
authors.forename: Oliver D
authors.initials: OD
authors.lastname: Schein
authors.forename: Albert
authors.initials: A
authors.lastname: Jun
mesh_terms: D000328:Adult; D015715:Corneal Edema / Q000473:pathology*; D003937:Diagnosis, Differential; D004728:Endothelium, Corneal / Q000473:pathology*; D006801:Humans; D007499:Iris Diseases / Q000473:pathology*; D008297:Male; D018613:Microscopy, Confocal; D013577:Syndrome