title: Subacute ruminal acidosis induces ruminal lipopolysaccharide endotoxin release and triggers an inflammatory response.
abstract: Subacute ruminal acidosis (SARA) was induced in 3 rumen fistulated Jersey steers by offering them different combinations of wheat-barley pellets and chopped alfalfa hay. Steers were offered 4, 5, and 6 kg/d of pelleted concentrate and 6, 5, and 4 kg/d of chopped alfalfa hay for diets 1, 2, and 3, respectively, during 5-d treatment periods and were fed chopped alfalfa hay between treatment periods. Inducing SARA increased blood concentrations of haptoglobin and serum amyloid-A. Dry matter intake of concentrate and hay decreased from d 1 to 5 in each period. Subacute ruminal acidosis was induced in all steers during d 4 and 5 when concentrate was fed, with ruminal pH remaining below 5.6 for an average of 187 and 174 min/d on these days. Lipopolysaccharide concentration increased significantly during periods of grain feeding compared with times when only hay was fed. Inducing SARA by feeding wheat-barley pellets activated a systemic inflammatory response in the steers.
authors.affiliation: Department of Animal Science, University of Manitoba, Winnipeg, Canada R3T 2N2.
authors.forename: G N
authors.initials: GN
authors.lastname: Gozho
authors.forename: J C
authors.initials: JC
authors.lastname: Plaizier
authors.forename: D O
authors.initials: DO
authors.lastname: Krause
authors.forename: A D
authors.initials: AD
authors.lastname: Kennedy
authors.forename: K M
authors.initials: KM
authors.lastname: Wittenberg
mesh_terms: D000138:Acidosis / Q000097:blood / Q000276:immunology / Q000378:metabolism / Q000662:veterinary*; D000210:Acute-Phase Reaction / Q000097:blood / Q000276:immunology / Q000378:metabolism / Q000662:veterinary; D000821:Animal Feed; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000276:immunology* / Q000378:metabolism*; D018592:Cross-Over Studies; D004731:Endotoxins / Q000096:biosynthesis; D006242:Haptoglobins / Q000032:analysis; D001467:Hordeum; D006863:Hydrogen-Ion Concentration; D008070:Lipopolysaccharides / Q000032:analysis*; D008297:Male; D000455:Medicago sativa; D011897:Random Allocation; D012417:Rumen / Q000737:chemistry / Q000378:metabolism*; D000685:Serum Amyloid A Protein / Q000032:analysis; D014908:Triticum
chemical_list: D004731:Endotoxins; D006242:Haptoglobins; D008070:Lipopolysaccharides; D000685:Serum Amyloid A Protein