A new perspective on tumor endothelial cells: unexpected chromosome and centrosome abnormalities.
It has been shown that endothelial cells in solid tumors are cytogenetically abnormal. These cells are aneuploid with multiple chromosomes and multiple centrosomes. Unlike normal endothelial cells which remain diploid in long-term culture, the aneuploidy of tumor endothelial cells is exacerbated in culture suggesting that these cells are inherently unstable. It is speculated that this instability might compromise the effectiveness of antiangiogenesis therapy.
Hida
Kyoko
K
Vascular Biology Program and Department of Surgery, Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Klagsbrun
Michael
M
D000782:Aneuploidy; D000818:Animals; D018385:Centrosome / Q000473:pathology*; D042783:Endothelial Cells / Q000648:ultrastructure*; D006801:Humans; D009369:Neoplasms / Q000098:blood supply*; D009389:Neovascularization, Pathologic / Q000235:genetics