title: Penetration and activity of antibiotics in brain abscess.
abstract: Penetration of antimicrobial agents into the cerebrospinal fluid is dependent on numerous factors, including their serum protein binding, molecular size and lipid solubility, and degree of local inflammation. The choice of an appropriate agent is further complicated by diverse bacterial flora involved in brain abscess, local resistant patterns and activity of the drug in abscess environment. This update examines the conventional and newer agents in the above context for their role in the management of brain abscess.
authors.affiliation: Department of Microbiology/Virology/Public Health, Health Protection Agency, Newcastle General Hospital, Newcastle, UK. mraza7@hotmail.com
authors.forename: Muhammad W
authors.initials: MW
authors.lastname: Raza
authors.forename: Amjad
authors.initials: A
authors.lastname: Shad
authors.forename: Steve J
authors.initials: SJ
authors.lastname: Pedler
authors.forename: Karamat A
authors.initials: KA
authors.lastname: Karamat
mesh_terms: D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001424:Bacterial Infections / Q000175:diagnosis / Q000188:drug therapy*; D001682:Biological Availability; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001922:Brain Abscess / Q000175:diagnosis / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents