title: E-cadherin, CD44s and CD44v6 correlate with tumour differentiation in colorectal cancer.
abstract: Cell adhesion molecules (CAMs) are cell surface glycoproteins that are important in cell-cell and cell-matrix interactions and play an important role in cell growth and differentiation. We examined immunohistochemically CD44s, CD44v6 and E-cadherin expression in 86 formalin-fixed, paraffin-embedded primary tumours and 5 metastases. Lower levels of CD44s, CD44v6 and membranous E-cadherin expression were significantly associated with higher tumour grade (p=0.022, p=0.016 and p= 0.041, respectively). Moreover, CD44v6 and membranous E-cadherin expression were correlated with the depth of primary tumour invasion (p=0.030 and p=0.020, respectively), and increased expression of CD44v6 and decreased membranous E-cadherin expression were associated with increased primary tumour invasion. The results suggest that these CAMs are associated with tumour differentiation and invasion in locally advanced and metastatic colorectal carcinoma.
authors.affiliation: Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland. riyben@utu.fi
authors.forename: R
authors.initials: R
authors.lastname: Bendardaf
authors.forename: A
authors.initials: A
authors.lastname: Elzagheid
authors.forename: H
authors.initials: H
authors.lastname: Lamlum
authors.forename: R
authors.initials: R
authors.lastname: Ristamäki
authors.forename: Y
authors.initials: Y
authors.lastname: Collan
authors.forename: S
authors.initials: S
authors.lastname: Pyrhönen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015820:Cadherins / Q000378:metabolism*; D002277:Carcinoma / Q000276:immunology / Q000401:mortality / Q000473:pathology; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000276:immunology* / Q000401:mortality / Q000473:pathology*; D005260:Female; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D016019:Survival Analysis; D013997:Time Factors
chemical_list: C473647:CD44S antigen; C112697:CD44v6 antigen; D015820:Cadherins; D006023:Glycoproteins; D018960:Hyaluronan Receptors