Erythrocyte senescence and haematological changes induced by starvation in the neotropical fish traíra, Hoplias malabaricus (Characiformes, Erythrinidae).
Adult specimens of traira (Hoplias malabaricus Bloch) were subjected to long-term starvation (30 to 240 days) and re-fed for 30 days after 90 and 240 days of food deprivation. Counting of immature erythrocytes in peripheral blood showed that erythropoiesis decreased significantly during the first 30 days of food deprivation. The results suggest that a process of senescence takes place in the pre-existent red blood cells and that the cells are not replaced during starvation. After 240 days of starvation, H. malabaricus had a significantly reduced number of red blood cells, causing changes in hematocrit and blood indices (mean corpuscular volume, mean corpuscular haemoglobin and mean corpuscular haemoglobin concentration). Furthermore, during this period, the fish presented leukopenia (lymphocytopenia) and thrombocytopenia. After re-feeding, the number of leukocytes and thrombocytes recovered, but the red blood cell number remained reduced and there was a significant increase in abnormal red cell nuclei.
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Department of Cell Biology, Federal University of Paraná, P.O. Box 19031, CEP 81531-970, Curitiba, PR, Brazil.
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Fernandes
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Kalinin
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D000821:Animal Feed; D000818:Animals; D001938:Brazil; D002467:Cell Nucleus / Q000648:ultrastructure; D016922:Cellular Senescence; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000648:ultrastructure; D004920:Erythropoiesis; D005399:Fishes / Q000097:blood*; D005508:Food Deprivation; D008231:Lymphopenia / Q000209:etiology; D013217:Starvation / Q000097:blood* / Q000150:complications; D013921:Thrombocytopenia / Q000209:etiology; D013997:Time Factors; D014329:Tropical Climate