title: Obesity-related correlation between C-reactive protein and the calculated 10-y Framingham Coronary Heart Disease Risk Score.
abstract: OBJECTIVE
  To clarify the role of body mass index (BMI, kg/m(2)) adjustment in predictive models for cardiovascular events that add high-sensitivity C-reactive protein (hs-CRP) to the 10-y Framingham Coronary Heart Disease Risk Score (FCRS).
  
  
  METHODS
  A cross-sectional study in a group of apparently healthy individuals.
  
  
  METHODS
  In all, 1512 apparently healthy individuals (955 men and 557 women) at a respective age of 49.7+/-10.6 and 50.6+/-9.6 y.
  
  
  RESULTS
  The Pearson correlation between hs-CRP and the calculated 10-y FCRS was lower when adjusted for BMI. This reduction was especially noted in women where it dropped from 0.247 to 0.09. The dominant role of hs-CRP concentrations was also noted in a linear regression model, again, especially noted in women (drop of the standardized coefficient from 0.517 for BMI to 0.08 for the FCRS).
  
  
  CONCLUSIONS
  The correlation between hs-CRP and the 10-y FCRS is partly related to the presence of obesity. We raise the possibility that the addition of BMI to the predictive model of FCRS might attenuate the cost-effectiveness of CRP measurements for this specific risk assessment.
authors.affiliation: Department of Medicine 'D' and Institute for Special Medical Examinations, Tel Aviv Sourasky Medical Center, affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: O
authors.initials: O
authors.lastname: Rogowski
authors.forename: I
authors.initials: I
authors.lastname: Shapira
authors.forename: S
authors.initials: S
authors.lastname: Toker
authors.forename: S
authors.initials: S
authors.lastname: Melamed
authors.forename: A
authors.initials: A
authors.lastname: Shirom
authors.forename: S
authors.initials: S
authors.lastname: Berliner
authors.forename: D
authors.initials: D
authors.lastname: Zeltser
mesh_terms: D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis*; D003430:Cross-Sectional Studies; D005260:Female; D006306:Health Surveys; D006331:Heart Diseases / Q000097:blood / Q000209:etiology*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications; D018570:Risk Assessment
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein