Hypoglycemic and antihyperglycemic effect of Gmelina asiatica LINN. in normal and in alloxan induced diabetic rats.
The hypoglycemic and antihyperglycemic effect of alcoholic extract of root of Gmelina asiatica LINN. (G. asiatica) was investigated in normal and in alloxan induced diabetic rats. The blood glucose levels were measured at 0 h and 1, 2, 4, 6, 8 and 16 h after the treatment. The alcoholic extract of G. asiatica showed significant (p<0.05) dose dependent percentage blood glucose reduction in normal (25.8% at 100 mg/kg, 28.9% at 250 mg/kg and 32.4% at 500 mg/kg body weight) and in diabetic rats (26.6% at 100 mg/kg, 32.1% at 250 mg/kg and 48.2% at 500 mg/kg body weight) respectively at 6 h. The antihyperglycemic effect of G. asiatica was compared with the reference standard drug tolbutamide (40 mg/kg).
Kasiviswanath
Routhu
R
Pharmacology Division, Department of Pharmaceutical Sciences, Andhra University, Pradesh, India. kasiviswanathr@rediffmail.com
Ramesh
Alluri
A
Kumar
Kilari Eswar
KE
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000633:toxicity; D019686:Lamiaceae / Q000737:chemistry*; D008297:Male; D051379:Mice; D020108:Nicorandil / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D014044:Tolbutamide / Q000494:pharmacology; D029648:Verbenaceae / Q000737:chemistry*
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D020108:Nicorandil; D014044:Tolbutamide