title: Inhalation of insulin (Exubera) is associated with augmented disposal of portally infused glucose in dogs.
abstract: The results of the present study, using the conscious beagle dog, demonstrate that inhaled insulin (INH; Exubera) provides better glycemic control during an intraportal glucose load than identical insulin levels induced by insulin (Humulin) infusion into the inferior vena cava (IVC). In the INH group (n = 13), portal glucose infusion caused arterial plasma glucose to rise transiently (152 +/- 9 mg/dl), before it returned to baseline (65 min) for the next 2 h. Net hepatic glucose uptake was minimal, whereas nonhepatic uptake rose to 12.5 +/- 0.5 mg x kg(-1) x min(-1) (65 min). In the IVC group (n = 9), arterial glucose rose rapidly (172 +/- 6 mg/dl) and transiently fell to 135 +/- 13 mg/dl (65 min) before returning to 165 +/- 15 mg/dl (125 min). Plasma glucose excursions and hepatic glucose uptake were much greater in the IVC group, whereas nonhepatic uptake was markedly less (8.6 +/- 0.9 mg x kg(-1) x min(-1); 65 min). Insulin kinetics and areas under the curve were identical in both groups. These data suggest that inhalation of Exubera results in a unique action on nonhepatic glucose clearance.
authors.affiliation: Molecular Physiology and Biophysics, Vanderbilt University Medical Center, 710 Robinson Research Bldg., Nashville, TN 37232-0615, USA. dale.edgerton@vanderbilt.edu
authors.forename: Dale S
authors.initials: DS
authors.lastname: Edgerton
authors.forename: Doss W
authors.initials: DW
authors.lastname: Neal
authors.forename: Melanie
authors.initials: M
authors.lastname: Scott
authors.forename: Larry
authors.initials: L
authors.lastname: Bowen
authors.forename: Warren
authors.initials: W
authors.lastname: Wilson
authors.forename: Charles H
authors.initials: CH
authors.lastname: Hobbs
authors.forename: Chet
authors.initials: C
authors.lastname: Leach
authors.forename: Shantha
authors.initials: S
authors.lastname: Sivakumaran
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Strack
authors.forename: Alan D
authors.initials: AD
authors.lastname: Cherrington
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D001786:Blood Glucose; D004285:Dogs; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism; D007262:Infusions, Intravenous; D007328:Insulin / Q000008:administration & dosage* / Q000494:pharmacology*; D008297:Male; D011169:Portal Vein; D014682:Vena Cava, Inferior
chemical_list: D001786:Blood Glucose; C473734:Exubera; D007328:Insulin; D005947:Glucose