title: Surface characterization of silver-doped bioactive glass.
abstract: A bioactive glass belonging to the system SiO(2)-CaO-Na(2)O was doped with silver ions by ion exchange in molten salts as well as in aqueous solution. The ion exchange in the solution was done to check if it is possible to prepare an antimicrobial material using a low silver content. The doped glass was characterized by means of X-ray diffraction, SEM observation, EDS analysis, bioactivity test (soaking in a simulated body fluid), leaching test (GFAAS analyses) and cytotoxicity test. It is demonstrated that these surface silver-doped glasses maintain, or even improve, the bioactivity of the starting glass. The measured quantity of released silver into simulated body fluid compares those reported in literature for the antibacterial activity and the non-cytotoxic effect of silver. Cytotoxicity tests were carried out to understand the effect of the doped surfaces on osteogenic cell adhesion and proliferation.
authors.affiliation: Materials Science and Chemical Engineering Department, Polytechnic of Turin C.so Duca degli Abruzzi 24 10129 Turin, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Vernè
authors.forename: S
authors.initials: S
authors.lastname: Di Nunzio
authors.forename: M
authors.initials: M
authors.lastname: Bosetti
authors.forename: P
authors.initials: P
authors.lastname: Appendino
authors.forename: C Vitale
authors.initials: CV
authors.lastname: Brovarone
authors.forename: G
authors.initials: G
authors.lastname: Maina
authors.forename: M
authors.initials: M
authors.lastname: Cannas
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D001826:Body Fluids / Q000737:chemistry; D002119:Calcium Carbonate / Q000737:chemistry; D002254:Carbonates / Q000737:chemistry; D002414:Cations, Monovalent; D049109:Cell Proliferation; D002470:Cell Survival; D017886:Durapatite / Q000737:chemistry; D004577:Electron Probe Microanalysis; D005898:Glass / Q000737:chemistry*; D006801:Humans; D007474:Ion Exchange; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts / Q000166:cytology; D012822:Silicon Dioxide / Q000737:chemistry; D012834:Silver / Q000737:chemistry*; D013052:Spectrometry, X-Ray Emission; D013054:Spectrophotometry, Atomic; D013499:Surface Properties; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D002254:Carbonates; D002414:Cations, Monovalent; D012834:Silver; C005686:sodium carbonate; D012822:Silicon Dioxide; D017886:Durapatite; D002119:Calcium Carbonate