Thrombosis in a pregnant hemophilia A carrier after intrapartum recombinant factor VIII.
BACKGROUND
Symptomatic hemophilia A is a rare disorder in females. Pregnancy and delivery in such women can be life threatening. Obstetric management is challenging and requires a multidisciplinary approach to ensure a good outcome.


METHODS
A woman with hemophilia A delivered by cesarean developed a deep vein thrombosis 10 days postpartum after recombinant factor VIII administration.


CONCLUSIONS
Hemophilia A due to skewed X-inactivation is a rare cause of peripartum bleeding. Recombinant factor VIII administration can prevent hemorrhage during and after cesarean delivery but may be associated with development of deep vein thrombosis.
Russell
Zoi
Z
Department of Obstetrics and Gynecology, Arnold Palmer Hospital for Children and Women, Orlando Regional Healthcare, Orlando, Florida, USA. zoika1@yahoo.com
Riconda
Dan
D
Pollack
Lynda
L
O'Leary
Timothy D
TD
Carlan
S J
SJ
D000328:Adult; D002585:Cesarean Section; D003937:Diagnosis, Differential; D005169:Factor VIII / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006467:Hemophilia A; D006579:Heterozygote; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D011644:Puerperal Disorders / Q000139:chemically induced / Q000175:diagnosis*; D011994:Recombinant Proteins / Q000008:administration & dosage* / Q000009:adverse effects; D020246:Venous Thrombosis / Q000139:chemically induced / Q000175:diagnosis*
D011994:Recombinant Proteins; D005169:Factor VIII