title: Relativistic parameters of senescence.
abstract: The laws of biochemistry and biology are governed by parameters whose description in mathematical formulas is based on the three-dimensional space. It is a fact, however, that the life span of a cell and its specific functions, though limited, can be extended or diminished depending on the genetic code but also, on the natural pressure of the environment. The plasticity exhibited by a cellular system has been attributed to the change of the three-dimensional structure of the cell, with time being a simple measure of this change. The model of biological relativity proposed here, considers time as a flexible fourth dimension that corresponds directly to the inertial status of the cells. Two types of clocks are defined: the relativistic biological clock (RBC) and the mechanical clock (MC). In contrast to the MCs that show the astrological reference time, the time shown by the RBCs delay because it depends on cellular activity. The maximum and the expected life span of the cells and/or the organisms can be therefore relied on time transformation. One of the most important factors that can affect time flow is the energy that is produced during metabolic work. Based on this observation, RBCs can be constructed following series of theoretical experiments in order to assess biological time and life span changes.
authors.affiliation: Diagnostic and Therapeutic Center of Athens Hygeia SA, Kifissias Avenue and Erythrou Stavrou Street, 15123 Marousi, Athens, Greece. papadop5@otenet.gr
authors.forename: Marios A
authors.initials: MA
authors.lastname: Stathatos
mesh_terms: D000375:Aging; D001683:Biological Clocks; D004358:Drug Therapy; D006801:Humans; D008962:Models, Theoretical; D009369:Neoplasms / Q000473:pathology; D011379:Prognosis; D013534:Survival