Covalent attachment of phospholipid analogous polymers to modify a polymeric membrane surface: a novel approach.
A novel method for the surface modification of a microporous polypropylene membrane by tethering phospholipid analogous polymers (PAPs) is given, which includes the photoinduced graft polymerization of N,N-dimethylaminoethyl methacrylate (DMAEMA) and the ring-opening reaction of grafted poly-(DMAEMA) with 2-alkyloxy-2-oxo-1,3,2-dioxaphospholanes. Five 2-alkyloxy-2-oxo-1,3,2-dioxaphospholanes, containing octyloxy, dodecyloxy, tetradecyloxy, hexadecyloxy, and octadecyloxy groups in the molecular structure, were used to fabricate the PAP-modified polypropylene membranes. The attenuated total reflectance FT-IR spectra of the original, poly(DMAEMA)-grafted, and PAP-modified membranes confirmed the chemical changes on the membrane surface. Scanning electron microscope pictures showed that, compared with the original membrane, the surface porosities ofpoly(DMAEMA)-grafted and PAP-modified membranes were somewhat reduced. Water contact angles measured by the sessile drop method on PAP-modified membranes were slightly lower than that on the original polypropylene membrane, but higher than those on poly(DMAEMA)-grafted membranes with the exception of octyloxy-containing PAP-modified membranes. However, BSA adsorption experiments indicated that the five PAP-modified membranes had a much better protein-resistant property than the original polypropylene membrane and the poly(DMAEMA)-grafted membranes. For hexadecyloxy- and octadecyloxy-containing PAP-modified membranes, almost no protein adsorption was observed when the grafting degree was above 6 wt %. It was also found that the platelet adhesion was remarkably suppressed on the PAP-modified membranes. All these results demonstrate that the described approach is an effective way to improve the surface biocompatibility for polymeric membranes.
Xu
Zhi-Kang
ZK
Institute of Polymer Science and Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China. xuzk@ipsm.zju.edu.cn
Dai
Qing-Wen
QW
Wu
Jian
J
Huang
Xiao-Jun
XJ
Yang
Qian
Q
D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials; D002417:Cattle; D006801:Humans; D008027:Light; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D008566:Membranes; D008567:Membranes, Artificial; D008689:Methacrylates / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D008956:Models, Chemical; D010743:Phospholipids / Q000737:chemistry*; D010973:Platelet Adhesiveness; D011092:Polyethylene Glycols; D011108:Polymers / Q000737:chemistry*; D011109:Polymethacrylic Acids; D011126:Polypropylenes / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000378:metabolism; D013053:Spectrophotometry; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D014466:Ultraviolet Rays
D001672:Biocompatible Materials; D008567:Membranes, Artificial; D008689:Methacrylates; D010743:Phospholipids; D011108:Polymers; D011109:Polymethacrylic Acids; D011126:Polypropylenes; D012710:Serum Albumin, Bovine; D011092:Polyethylene Glycols; C049840:2-(dimethylamino)ethyl methacrylate