Synthesis and anticonvulsant activity of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles.
A series of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles have been synthesized and evaluated as anticonvulsant agents. Compound 4b shows considerable anticonvulsant activity both in PTZ and MES models. It seems this effect is mediated through benzodiazepine receptors mechanism.
Zarghi
Afshin
A
Department of Medicinal Chemistry, Faculty of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran 141556153, Iran. azarghi@yahoo.com
Tabatabai
Sayyed A
SA
Faizi
Mehrdad
M
Ahadian
Avideh
A
Navabi
Parisa
P
Zanganeh
Vahideh
V
Shafiee
Abbas
A
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D001593:Benzyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D004597:Electroshock / Q000379:methods; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D010433:Pentylenetetrazole; D011963:Receptors, GABA-A / Q000378:metabolism; D013329:Structure-Activity Relationship
D000927:Anticonvulsants; D001593:Benzyl Compounds; D010069:Oxadiazoles; D011963:Receptors, GABA-A; D010433:Pentylenetetrazole