title: Diffuse pulmonary hamartoma: a case report.
abstract: Pulmonary hamartoma usually occurs as a benign, well-circumscribed single nodule in the lung parenchyma. We report on a unique case of hamartoma that extended along the bronchial tree, formed endobronchial polypoid lesions, and expanded into the lung parenchyma. The patient, a 48-year-old man, was admitted with dyspnea and chest pain. A transbronchial biopsy was performed on a tumorous lesion that was diagnosed histologically as a hamartoma. As this lesion was found to be growing diffusely along the bronchial tree, a left pneumonectomy was performed. Gross examination showed that yellowish soft tissue had surrounded the bronchial tree and extended into the lung parenchyma. Histologically, the lesion contained mainly mature adipose tissue, cartilage, and muscle tissue with a minor component of short spindle cells in a myxomatous matrix. The patient was diagnosed as having diffuse pulmonary hamartoma.
authors.affiliation: Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Minami
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Iijima
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Yukio
authors.initials: Y
authors.lastname: Morishita
authors.forename: Hideo
authors.initials: H
authors.lastname: Terashima
authors.forename: Masataka
authors.initials: M
authors.lastname: Onizuka
authors.forename: Masayuki
authors.initials: M
authors.lastname: Noguchi
mesh_terms: D002467:Cell Nucleus / Q000473:pathology; D002637:Chest Pain / Q000209:etiology / Q000473:pathology / Q000601:surgery; D004417:Dyspnea / Q000209:etiology / Q000473:pathology / Q000601:surgery; D006222:Hamartoma / Q000150:complications / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008171:Lung Diseases / Q000150:complications / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy; D013902:Radiography, Thoracic; D016896:Treatment Outcome