title: Exposure to traffic exhausts and oxidative DNA damage.
abstract: OBJECTIVE
  To assess the relations between exposure to traffic exhausts and indicators of oxidative DNA damage among highway toll station workers.
  
  
  METHODS
  Cross-sectional study of 47 female highway toll station workers exposed to traffic exhausts and 27 female office workers as a reference group. Exposure assessment was based on average and cumulative traffic density and a biomarker of exposure, urinary 1-hydroxypyrene-glucuronide (1-OHPG). Urinary 8-hydroxydeoxyguanosine (8-OHdG) was used as a biomarker of oxidative DNA damage. Plasma nitric oxide (NO) was measured as an indicator of oxidative stress related to traffic exhaust exposure.
  
  
  RESULTS
  The mean concentration of urinary 8-OHdG was substantially higher among the exposed non-smokers (13.6 microg/g creatinine) compared with the reference non-smokers (7.3 microg/g creatinine; difference 6.3, 95% CI 3.0 to 9.6). The mean concentration of NO among the exposed (48.0 micromol/l) was also higher compared with the reference non-smokers (37.6 micromol/l; difference 10.4, 95% CI -0.4 to 21.2). In linear regression adjusting for confounding, a change in log(8-OHdG) was statistically significantly related to a unit change in log(1-OHPG) (beta = 0.372, 95% CI 0.081 to 0.663).
  
  
  CONCLUSIONS
  Results indicate that exposure to traffic exhausts increases oxidative DNA damage. Urinary 8-OHdG is a promising biomarker of traffic exhaust induced oxidative stress.
authors.affiliation: Department of Public Health, National Defence Medical Center, Taipei, Taiwan 114, ROC. lgh@ndmctsgh.edu.tw
authors.forename: C-H
authors.initials: CH
authors.lastname: Lai
authors.forename: S-H
authors.initials: SH
authors.lastname: Liou
authors.forename: H-C
authors.initials: HC
authors.lastname: Lin
authors.forename: T-S
authors.initials: TS
authors.lastname: Shih
authors.forename: P-J
authors.initials: PJ
authors.lastname: Tsai
authors.forename: J-S
authors.initials: JS
authors.lastname: Chen
authors.forename: T
authors.initials: T
authors.lastname: Yang
authors.forename: J J K
authors.initials: JJ
authors.lastname: Jaakkola
authors.forename: P T
authors.initials: PT
authors.lastname: Strickland
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D000395:Air Pollutants, Occupational / Q000633:toxicity*; D015415:Biomarkers / Q000652:urine; D003430:Cross-Sectional Studies; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D005260:Female; D005965:Glucuronates / Q000652:urine; D006801:Humans; D009569:Nitric Oxide / Q000097:blood; D016273:Occupational Exposure / Q000009:adverse effects; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D011721:Pyrenes; D001335:Vehicle Emissions / Q000633:toxicity*
chemical_list: C093851:1-hydroxypyrene-glucuronide; D000395:Air Pollutants, Occupational; D015415:Biomarkers; D005965:Glucuronates; D011721:Pyrenes; D001335:Vehicle Emissions; D009569:Nitric Oxide; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine