[Cytokines in complex treatment of posttraumatic empyema of the pleura].
Results of treatment of 114 patients with posttraumatic empyema of the pleura (EP) after closed injury of the thorax (62), stab-incised (43) and missile (9) wounds are presented. In complex treatment of 25 patients one of cytokines - recombinant interleukin-1v (betaleukin) -- was administered intravenously (10 patients) and intrapleurally (15 patients). Control group consisted of 35 similar patients treated with traditional methods including drainage and sanitation of empyema's cavity with protheolytic enzymes, antibacterial and detoxication therapy. Comparative analysis has demonstrated that patients of the study group showed fast normalization of immunogram's parameters, decrease of duration of purulent process (51+/-4 days, on the average, in the control group and 28+/-3 days in the study group) due to fast obliteration of purulent cavity, and decrease of rate of chronic forms of EP (from 20 to 4%) which required surgical treatment.
Abakumov
M M
MM
Danielian
Sh N
ShN
Bulava
G V
GV
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000276:immunology; D004322:Drainage / Q000379:methods*; D016724:Empyema, Pleural / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007375:Interleukin-1 / Q000008:administration & dosage*; D018655:Lymphocyte Count; D008297:Male; D011994:Recombinant Proteins / Q000008:administration & dosage*; D016060:Sorption Detoxification; D013601:T-Lymphocytes / Q000276:immunology; D013898:Thoracic Injuries / Q000150:complications*; D016896:Treatment Outcome; D014948:Wounds, Gunshot / Q000150:complications; D014949:Wounds, Nonpenetrating / Q000150:complications; D014951:Wounds, Stab / Q000150:complications
D000900:Anti-Bacterial Agents; D007375:Interleukin-1; D011994:Recombinant Proteins