In silico identification of regulatory elements of GRIN1 genes.
The ionotropic receptor of glutamate activated by N-methyl-D-aspartate (iGluR-NMDA) is a multiheteromeric complex constituted by at least three different types of subunits, encoded by seven different genes. The subunits of iGluR-NMDA have a complex system of regulation of their gene expression. Their expression is specific for each type of neural cell, as well as for the age of the organism. Moreover, there are reports that iGluR-NMDA expression is species-specific. Even though this macromolecular complex is very important in physiology and pathology of the central nervous system, knowledge to date about the regulatory elements controlling expression is scarce. We present the results of an in silico prediction of potential regulatory elements, some of which coincide with the few known experimentally. We also present the important differences regarding the presence and the localization of the regulatory elements among human, rat, and mouse species.
Mejía-Guerra
María Katherine
MK
Department of Nutrition and Biochemistry, Computational and Structural Biochemistry and Bioinformatics, Pontificia Universidad Javeriana, Bogotá, Colombia.
Lareo
Leonardo R
LR
D000465:Algorithms; D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D002490:Central Nervous System / Q000502:physiology; D005786:Gene Expression Regulation; D005809:Genes, Regulator; D005821:Genetic Techniques; D016678:Genome; D015894:Genome, Human; D006801:Humans; D051379:Mice; D008954:Models, Biological; D016202:N-Methylaspartate / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics*; D012984:Software; D013045:Species Specificity
D002352:Carrier Proteins; C485668:GRIN1 protein, human; C121673:Gprin1 protein, mouse; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D016194:Receptors, N-Methyl-D-Aspartate; D016202:N-Methylaspartate