title: [Chemical constituents from marine alga Chaetomorpha basiretorsa].
abstract: OBJECTIVE
  To investigate the chemical constituents of marine alga Chaetomorpha basiretorsa.
  
  
  METHODS
  Compounds were isolated by normal phase silica gel and Sephadex LH-20 gel colum chromatography, reverse phase MPLC, reverse phase HPLC and recrystallization. Their structures were elucidated by spectroscopic methods including MS, IR, NMR, and X-ray crystalography. Cytotoxicity of the compounds were screened by using standard MTT method.
  
  
  RESULTS
  Nine compounds were isolated from C. basiretorsa and their structures were identified as N-phenyl-2-naphthalenamine( I ), dibutyl phthalate( II ), diisobutyl phthalate( III ), 1-phenyl-ethane-1, 2-diol( IV ), 2-hydrox-gamma-benzaldehyde( V ), diethyleneglycol monobenzoate( VI ), uracil( VII ), thymine( VIII ) and thymidine( IX ).
  
  
  CONCLUSIONS
  All these compounds were obtained from this genus for the first time, N-phenyl-2-naphthalenamine and diethyleneglycol monobenzoate were first reported from the marine organisms. Compound I and VII showed moderate activity against KB cell(IC50 10.15 microg x mL(-1) for I and 3.79 microg x mL(-1) for VII ) and MCF-7 cell(IC50 3.24 microg x mL(-1) for VII).
authors.affiliation: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
authors.forename: Da-yong
authors.initials: DY
authors.lastname: Shi
authors.forename: Li-jun
authors.initials: LJ
authors.lastname: Han
authors.forename: Jie
authors.initials: J
authors.lastname: Sun
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Yong-chun
authors.initials: YC
authors.lastname: Yang
authors.forename: Jian-gong
authors.initials: JG
authors.lastname: Shi
authors.forename: Xiao
authors.initials: X
authors.lastname: Fan
mesh_terms: D015057:1-Naphthylamine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D000460:Chlorophyta / Q000737:chemistry*; D003460:Crystallization; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D014498:Uracil / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C505278:N-phenyl-2-naphthalenamine; D014498:Uracil; D015057:1-Naphthylamine