Expression of interleukins in patients with nasal polyposis.
OBJECTIVE
To correlate the levels of interleukins 1beta, 3, 4, and 5 before and after surgery and compare the levels between patients with and without recurrence of nasal polyposis.


METHODS
Thirty-nine patients with NP were selected, 13 of them allergic and 26 nonallergic. A control group of 11 individuals was also studied. The concentrations of interleukins were measured by enzyme-linked immunosorbent assay.


RESULTS
There was a higher incidence of NP after the fourth decade of life and among men. The clinical symptoms were similar in both groups of patients with nasal polyposis and characterized by nasal obstruction and anosmia. A significant reduction of all interleukins studied was observed after surgical treatment.


CONCLUSIONS
Levels of interleukins 1beta, 3, 4, and 5 were significantly reduced after surgery and the levels of interleukins 1beta and 5 were significantly lower in patients without recurrence of nasal polyposis after surgery when compared to those with recurrence.
Voegels
Richard Louis
RL
Division of Otorhinolaryngological Clinic at Clinical Hospital of the University of São Paulo, Brazil. rvoegels@attglobal.net
de Melo Pádua
Francini Grecco
FG
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007378:Interleukins / Q000378:metabolism*; D008297:Male; D009297:Nasal Mucosa / Q000276:immunology / Q000473:pathology / Q000601:surgery; D009298:Nasal Polyps / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D010256:Paranasal Sinuses / Q000276:immunology / Q000473:pathology / Q000601:surgery; D011183:Postoperative Complications / Q000276:immunology; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology* / Q000473:pathology / Q000601:surgery
D007378:Interleukins