title: Experimental therapeutic intervention with ascorbic acid in ethanol induced testicular injuries in rats.
abstract: Ascorbic acid treatment significantly increased the activities of testicular delta5, 3beta-HSD and 17beta-HSD. Moreover, the treatment was also associated with significant decrease in oxidative stress in the testis. Ethanol induced oxidative stress and decreased steroidogenesis can be reversed by treatment with ascorbic acid.
authors.affiliation: Department of Biochemistry, Sikkim Manipal Institute of Medicine Sciences, Gangtok, India.
authors.forename: M
authors.initials: M
authors.lastname: Maneesh
authors.forename: H
authors.initials: H
authors.lastname: Jayalakshmi
authors.forename: Sanjiba
authors.initials: S
authors.lastname: Dutta
authors.forename: Amit
authors.initials: A
authors.lastname: Chakrabarti
authors.forename: D M
authors.initials: DM
authors.lastname: Vasudevan
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D000431:Ethanol / Q000633:toxicity*; D005978:Glutathione / Q000378:metabolism; D012739:Gonadal Steroid Hormones / Q000096:biosynthesis; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D013737:Testis / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism
chemical_list: D000975:Antioxidants; D012739:Gonadal Steroid Hormones; D008054:Lipid Peroxides; D000431:Ethanol; D005978:Glutathione; D001205:Ascorbic Acid