title: Immune surveillance and anti-tumor immune responses: an anatomical perspective.
abstract: The development of adaptive immune responses against infectious agents relies on the initiation of antigen specific immune responses in secondary lymphoid organs and on the migration of effector cells at the site of infection. Similarly, the development of anti-tumor immunity depends on the recognition of tumor-derived antigens by specific lymphocytes in the context of the lymphoid tissues and on the re-localisation of the cells to the site of cell transformation. Here, we will review the preclinical studies, which have defined the spatial and temporal organisation of anti-tumor immunity, and discuss the implications of these findings in active immunotherapy.
authors.affiliation: Cancer Immunotherapy and Gene Therapy Program, San Raffaele Scientific Institute, DIBIT, Via Olgettina 58, 20132 Milan, Italy.
authors.forename: Valerie S
authors.initials: VS
authors.lastname: Zimmermann
authors.forename: Fabio
authors.initials: F
authors.lastname: Benigni
authors.forename: Anna
authors.initials: A
authors.lastname: Mondino
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D019496:Cancer Vaccines / Q000276:immunology; D006801:Humans; D016233:Immunotherapy, Active; D008214:Lymphocytes / Q000276:immunology; D008221:Lymphoid Tissue / Q000276:immunology; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology*
chemical_list: D000951:Antigens, Neoplasm; D019496:Cancer Vaccines