[Effects of Peritrophe roxburghiana on blood pressure in renal hypertensive and hyperlipidemic rats].
OBJECTIVE
To observe the effects of Peristrophe roxburghiana (HSX) on the blood pressure in renal hypertensive and hyperlipidemic rats (RHHR), and investigate the possible mechanisms of its pharmacological effects.


METHODS
The two-kidney, two-clip method was used to produce the renovascular hypertensive rats, then high lipid emulsion was administered to produce the model of hyperlipidemic rats. Drugs were administered for 5 weeks. Blood pressure was measured weekly before and after administration. After rats were killed at the end of the 5th week,blood was sampled to measure plasma angiotensin IT and serum NO. Angiotensin II in the thoratic aorta was measured too.


RESULTS
The BP decreased significantly to the end of 5th week (P < 0.05) after treatment of 1-2 weeks with HSX. HSX (H or L dosage) increased the level of serum NO evidently at the end of the experiment. No significant statistical difference was found in the level of plasma angiotensin, but HSX(H) and captopril decreased the value of angiotensin II in blood vessel (P < 0.01).


CONCLUSIONS
HSX decreased the blood pressure significantly for RHHR and the mechanism of its antihypertensive effect was possibly related to the increasing of serum NO and the decreasing of angiotensin II1 in the thoratic aorta.
Cheng
Zhaohui
Z
Pharmacy College of Jinan University, Guangzhou.
Lü
Junhua
J
Liu
Jianjun
J
D027901:Acanthaceae / Q000737:chemistry*; D000804:Angiotensin II / Q000097:blood; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006949:Hyperlipidemias / Q000503:physiopathology*; D006978:Hypertension, Renovascular / Q000503:physiopathology*; D008297:Male; D009569:Nitric Oxide / Q000097:blood; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
D000959:Antihypertensive Agents; D004365:Drugs, Chinese Herbal; D000804:Angiotensin II; D009569:Nitric Oxide