Linking Rap to cell adhesion.
The small GTPase Rap1 is involved in several aspects of cell adhesion, including integrin-mediated cell adhesion and cadherin-mediated cell junction formation. Recently, several effector proteins for Rap1 have been identified providing a clear link between Rap1 and actin dynamics. Furthermore, evidence is accumulating that Rap1 functions in the spatial and temporal control of cell polarity.
Bos
Johannes L
JL
Department of Physiological Chemistry and Centre for Biomedical Genetics, UMC Utrecht, Universiteitsweg 100, 3584CG Utrecht, The Netherlands. j.l.bos@med.uu.nl
D008841:Actin Cytoskeleton / Q000378:metabolism*; D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism*; D016764:Cell Polarity / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D015290:Second Messenger Systems / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D020827:rap1 GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism*
D020827:rap1 GTP-Binding Proteins