A new modified technique of ureteroureterostomy in rat kidney transplantation.
Different strain combinations of rat are available to study immunological and transplant-related problems in kidney transplant models. Although numerous modifications of surgical techniques for ureteric reconstruction have been evaluated in order to reduce complications and to extend long-term survival, ureteric complications still occur frequently, especially when there is a disproportion in the diameter of donor and host ureters. Instead of using the current nonsplinted ureteroureterostomy, a versatile and rapid technical modification was developed to perform reconstruct the ureters of disproportionate diameter. The overall incidence of ureteric complications was 80% (8/10) using the former method, whereas this rate was significantly reduced to 15% (3/20) using the new method (P < .001). Our modification shows the feasibility of a nonsplinted ureteroureterostomy for the technical, highly demanding rat model of kidney transplantation with an acceptable rate of ureteric complications considering disproportionate differences in diameter between the host and the donor ureter.
Pietsch
A P
AP
Division of General Vascular, Thoracic and Transplantation Surgery, Rostock University, Rostock, Germany.
Nett
P C
PC
Klar
E
E
Sollinger
H W
HW
Hullett
D A
DA
D000818:Animals; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D023421:Models, Animal; D009392:Nephrectomy / Q000379:methods; D051381:Rats; D011914:Rats, Inbred BN; D011919:Rats, Inbred Strains; D020858:Tissue and Organ Harvesting / Q000379:methods; D014519:Ureterostomy / Q000379:methods*