title: Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines.
abstract: From the rhizomes of Belamcanda chinensis, three new compounds, belalloside A (1), belalloside B (2), and belamphenone (3), along with 13 known compounds, resveratrol (4), iriflophenone (5), irisflorentin (6), tectorigenin (7), irilin D (8), tectoridin (9), iristectorin A (10), iristectorin B (11), hispiduloside, androsin, irigenin, iridin, and jaceoside, have been isolated and characterized. Isolates were evaluated for their cell proliferation stimulatory activity against the MCF-7 and T-47D human breast cancer cell lines. Along with 4, 5, 7, and 9, 3 was shown to stimulate not only MCF-7 but also T-47D human breast cancer cell proliferation.
authors.affiliation: Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Orawan
authors.initials: O
authors.lastname: Monthakantirat
authors.forename: Wanchai
authors.initials: W
authors.lastname: De-Eknamkul
authors.forename: Kaoru
authors.initials: K
authors.lastname: Umehara
authors.forename: Yohko
authors.initials: Y
authors.lastname: Yoshinaga
authors.forename: Toshio
authors.initials: T
authors.lastname: Miyase
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Warashina
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Noguchi
mesh_terms: D001943:Breast Neoplasms; D049109:Cell Proliferation / Q000187:drug effects; D005260:Female; D006801:Humans; D027621:Iridaceae / Q000737:chemistry*; D007529:Isoflavones / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D000077185:Resveratrol; D027343:Rhizome / Q000737:chemistry; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013785:Thailand; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D007529:Isoflavones; D010636:Phenols; D013267:Stilbenes; C499934:belalloside A; C499935:belalloside B; C499936:belamphenone; C570745:irisflorentin; D000077185:Resveratrol