title: No major effect of the insulin-like growth factor I gene on bone mineral density in premenopausal Chinese women.
abstract: Osteoporosis is a major public health problem, mainly characterized by low bone mineral density (BMD). BMD is a complex trait that is determined by multiple genes. Insulin-like growth factor I (IGF-I) is an important growth factor of bone and thus IGF-I gene has been considered as an attractive candidate gene for osteoporosis. A few studies on the relationship between variants of the IGF-I gene and BMD variation, via traditional association and/or linkage methods, have yielded conflicting results. In this study, we simultaneously tested association and/or linkage of a cytosine-adenine (CA) repeat polymorphism at 1 kb upstream of the transcription initiation site of the IGF-I gene with BMD variation in a large cohort of premenopausal Chinese women. A total of 1263 subjects from 402 Chinese nuclear families were examined. Each family consists of both parents and at least one daughter aged between 20 and 45 years. BMDs (g/cm(2)) at the lumbar spine and hip were measured using dual-energy X-ray absorptiometry (DXA). Applying the QTDT (quantitative transmission disequilibrium tests) progam, we did not find significant evidence of association or linkage between the CA repeat polymorphism of the IGF-I gene and BMD variation at any skeletal site. Our data do not support the IGF-I gene having major effect on BMD variation in premenopausal Chinese women.
authors.affiliation: Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, P. R. China.
authors.forename: De-Ke
authors.initials: DK
authors.lastname: Jiang
authors.forename: Hui
authors.initials: H
authors.lastname: Shen
authors.forename: Miao-Xin
authors.initials: MX
authors.lastname: Li
authors.forename: Cheng
authors.initials: C
authors.lastname: Jiang
authors.forename: Na
authors.initials: N
authors.lastname: Yang
authors.forename: Jie
authors.initials: J
authors.lastname: Zhu
authors.forename: Yong
authors.initials: Y
authors.lastname: Wu
authors.forename: Yue-Juan
authors.initials: YJ
authors.lastname: Qin
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhou
authors.forename: Hong-Wen
authors.initials: HW
authors.lastname: Deng
mesh_terms: D000483:Alleles; D015519:Bone Density / Q000235:genetics*; D002681:China; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D008875:Middle Aged; D017697:Premenopause
chemical_list: D007334:Insulin-Like Growth Factor I