Nucleotide correlations and electronic transport of DNA sequences.
We use a tight-binding formulation to investigate the transmissivity and wave-packet dynamics of sequences of single-strand DNA molecules made up from the nucleotides guanine G , adenine A , cytosine C , and thymine T . In order to reveal the relevance of the underlying correlations in the nucleotides distribution, we compare the results for the genomic DNA sequence with those of two artificial sequences: (i) the Rudin-Shapiro one, which has long-range correlations; (ii) a random sequence, which is a kind of prototype of a short-range correlated system, presented here with the same first-neighbor pair correlations of the human DNA sequence. We found that the long-range character of the correlations is important to the persistence of resonances of finite segments. On the other hand, the wave-packet dynamics seems to be mostly influenced by the short-range correlations.
Albuquerque
E L
EL
Departamento de Física, Universidade Federal do Rio Grande do Norte, 59072-970 Natal-RN, Brazil.
Vasconcelos
M S
MS
Lyra
M L
ML
de Moura
F A B F
FA
D001483:Base Sequence; D003198:Computer Simulation; D004247:DNA / Q000032:analysis* / Q000737:chemistry*; D004553:Electric Conductivity; D004579:Electron Transport; D008956:Models, Chemical; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D009711:Nucleotides / Q000737:chemistry*; D017422:Sequence Analysis, DNA / Q000379:methods*; D013223:Statistics as Topic; D013329:Structure-Activity Relationship
D009711:Nucleotides; D004247:DNA