Tat inhibitors, a new approach: interview with Olaf Kutsch, Ph.D. Interview by John S. James.
An important potential target for antiretrovirals is the HIV protein Tat (produced by the virus and essential for infection, but is not used by the human body). Years ago, a Tat inhibitor worked well in the laboratory but failed in patients. Modern biotechnology may have shown why--and how to screen for drugs more likely to work.
Kutsch
Olaf
O
D019380:Anti-HIV Agents / Q000494:pharmacology*; D004345:Drug Industry; D015696:Gene Products, tat / Q000037:antagonists & inhibitors*
D019380:Anti-HIV Agents; D015696:Gene Products, tat