The significance of individual resistance to hypoxia for correction of the consequences of craniocerebral trauma.
Experiments on rats showed that the individual resistance of the body to acute hypoxia is of decisive importance in the early recovery period after mechanical craniocerebral trauma. I.p. administration of ethomersol (25 mg/kg) during the three days following trauma decreased behavioral impairments in rats with different levels of resistance to acute hypoxia, restored the structure of individual behavior, and prevented metabolic disturbances in the brain. The results led to the conclusion that the antioxidant ethomersol is effective in hypoxia due to craniocerebral trauma.
Zarubina
I V
IV
Department of Pharmacology, Military Medical Academy, 6 Lebedev Street, 194044 St. Petersburg, Russia.
Shabanov
P D
PD
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D001562:Benzimidazoles / Q000627:therapeutic use*; D001831:Body Temperature / Q000187:drug effects / Q000502:physiology; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D001929:Brain Edema / Q000188:drug therapy / Q000503:physiopathology; D006259:Craniocerebral Trauma / Q000188:drug therapy* / Q000503:physiopathology; D004195:Disease Models, Animal; D004734:Energy Metabolism / Q000187:drug effects; D007839:Functional Laterality / Q000187:drug effects / Q000502:physiology; D000860:Hypoxia / Q000378:metabolism / Q000503:physiopathology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D010889:Piracetam / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012119:Respiration / Q000187:drug effects
D000975:Antioxidants; D001562:Benzimidazoles; C070941:ethomersol; D010889:Piracetam