[Effect of amlodipine on intravascular thrombocyte activity in patients with arterial hypertension and metabolic syndrome].
In order to evaluate therapeutic effects of amlodipine on intravascular thrombocyte activity (ITA) in patients having arterial hypertension (AH) with metabolic syndrome (MS), 20 patients were treated with amlodipine for 1 month. The researchers monitored changes in anthropometric indices, blood lipid spectrum, lipid peroxidation in serum and thrombocytes, anti-oxidant protectability of platelets and the liquid part of blood and ITA. Amlodipine application in patients having AH with MS reduced peroxidation syndrome and optimized thrombocyte aggregation. Long-term administration of amlodipine stabilizes the achieved effect. To lower body weight in patients having AH with MS administration of amlodipine should be combined with use of non-drug means.
Medvedev
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IN
Gromnatskiĭ
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NI
D000328:Adult; D000368:Aged; D017311:Amlodipine / Q000008:administration & dosage / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications / Q000188:drug therapy*; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications; D008875:Middle Aged; D016896:Treatment Outcome
D000959:Antihypertensive Agents; D015415:Biomarkers; D008055:Lipids; D017311:Amlodipine