HR, 0-(beta-hydroxyethyl)-rutosides; (Venoruton): rapid relief of signs/symptoms in chronic venous insufficiency and microangiopathy: a prospective, controlled study.
The aim of this independent study was to demonstrate the rapidity of the clinical action of HR 0-(beta-hydroxyethyl)-rutosides, Venoruton (Novartis Consumer Health) in patients with chronic venous insufficiency (CVI). Two groups of patients with venous hypertension and microangiopathy were treated with HR (1 or 2 g/day, for 8 weeks). Twelve patients (age 56.4; range 44-66; M:F = 6:6) were included in group 1 (1 g/day) (moderate CVI and microangiopathy); 10 patients (age 57.4; range 42-67; M:F = 5:5) in group 2 (2 g/day) with more severe CVI and microangiopathy. Average ambulatory venous pressure (AVP) was 58.6 (range 50-65) with a refilling time (RT) shorter than 10 seconds. There were no significant differences in AVP and RT between the 2 groups, but the duration of the disease was longer in group 2: 3.5 years (SD 2.0) in group 1 and 6.4 years (SD 3.3) in group 2. All included subjects completed the study and no dropouts were observed. In both dose groups there was a progressive decrease in laser Doppler resting flux (RF), indicating improvement in microangiopathy and a significant decrease in capillary filtration (RAS) associated with a significant improvement in analogue scale line score (ASLS) and edema. Although the effect in the 2 g dose group was more rapid on the microcirculatory parameters with a significant effect on RF and RAS after 4 days (effect of 1 g per day after 8 days and 6 days, respectively), there was no difference in the time to onset of a significant clinical improvement (ie, the ASLS and the edema score): 4 days in both groups. Venous microangiopathy and edema were improved by the treatment with HR within a few days. The effects were visible with both dosages, in both severity groups.
Cesarone
M R
MR
Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G. D'Annunzio, Chieti-Pescara University, San Valentino Vascular Screening Project, San Valentino, Italy.
Belcaro
G
G
Pellegrini
L
L
Ledda
A
A
Vinciguerra
G
G
Ricci
A
A
Gizzi
G
G
Ippolito
E
E
Fano
F
F
Dugall
M
M
Acerbi
G
G
Cacchio
M
M
Di Renzo
A
A
Stuard
S
S
Corsi
M
M
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D002199:Capillary Permeability / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006896:Hydroxyethylrutoside / Q000008:administration & dosage* / Q000009:adverse effects / Q000031:analogs & derivatives*; D017078:Laser-Doppler Flowmetry; D007866:Leg / Q000098:blood supply*; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D008875:Middle Aged; D010991:Plethysmography; D011208:Powders; D011446:Prospective Studies; D014662:Vasoconstrictor Agents / Q000008:administration & dosage* / Q000009:adverse effects; D014689:Venous Insufficiency / Q000188:drug therapy*
D006896:Hydroxyethylrutoside; D011208:Powders; D014662:Vasoconstrictor Agents; C005865:troxerutin