Alterations of leptin and ghrelin serum concentrations in renal disease: simple epiphenomena?
The hypothesis that alterations of serum concentrations of the anorexigenic adipose tissue-derived hormone leptin or the orexigenic peptide ghrelin might help to regain appetite and fight malnutrition in patients with chronic renal failure cannot be confirmed at present. For the future, however, strategies interfering with signal transduction of these peptides in the hypothalamus might be more promising and should be investigated and further developed.
Dötsch
Jörg
J
Nüsken
Kai
K
Schroth
Michael
M
Rascher
Wolfgang
W
Meissner
Udo
U
D001066:Appetite; D018450:Disease Progression; D054439:Ghrelin; D006801:Humans; D007674:Kidney Diseases / Q000097:blood* / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000097:blood / Q000503:physiopathology; D020738:Leptin / Q000097:blood*; D009994:Osmolar Concentration; D036361:Peptide Hormones / Q000097:blood*; D014511:Uremia / Q000097:blood / Q000503:physiopathology
D054439:Ghrelin; D020738:Leptin; D036361:Peptide Hormones