title: Infection with HIV-1 induces a decrease in mtDNA.
abstract: Cross-sectional studies have suggested that infection with human immunodeficiency virus (HIV) type 1 could reduce the mitochondrial DNA (mtDNA) content of blood cells. We investigated mtDNA content in peripheral blood mononuclear cells (PBMCs) obtained from 36 antiretroviral therapy-naive documented HIV-1 seroconverters, before and after seroconversion. mtDNA content statistically significantly decreased 1 year after seroconversion and showed a nonsignificant decrease during the subsequent 4 years. These findings confirm that infection with HIV-1 may, itself, reduce mtDNA content, at least within PBMCs. This could have implications for the subsequent development of mitochondrial toxicities associated with the use of nucleoside analogue reverse-transcriptase inhibitors.
authors.affiliation: International Antiviral Therapy Evaluation Center, Amsterdam, The Netherlands. m.casula@amc.uva.nl
authors.forename: Miriam
authors.initials: M
authors.lastname: Casula
authors.forename: Irene
authors.initials: I
authors.lastname: Bosboom-Dobbelaer
authors.forename: Karlijn
authors.initials: K
authors.lastname: Smolders
authors.forename: Sigrid
authors.initials: S
authors.lastname: Otto
authors.forename: Margreet
authors.initials: M
authors.lastname: Bakker
authors.forename: Michel P
authors.initials: MP
authors.lastname: de Baar
authors.forename: Peter
authors.initials: P
authors.lastname: Reiss
authors.forename: Anthony
authors.initials: A
authors.lastname: de Ronde
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000235:genetics*; D018791:CD4 Lymphocyte Count; D004272:DNA, Mitochondrial / Q000097:blood / Q000235:genetics*; D006679:HIV Seropositivity / Q000276:immunology; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D007963:Leukocytes, Mononuclear; D008137:Longitudinal Studies; D008297:Male
chemical_list: D004272:DNA, Mitochondrial