Current thinking on the relationship between rhinosinusitis and asthma.
An observation made initially on clinical grounds and epidemiologic evidence, i.e., that rhinosinusitis and asthma are closely linked diseases is now supported by a growing body of scientific evidence. Most recent evidence supports the characterization of rhinosinusitis and asthma as two compartmental expressions of a common mucosal susceptibility to exogenous stimuli. In addition, there is evidence that the compartmental processes can affect and amplify each other via a systemic intermediary. The bone marrow is involved in this process, and IL-5 may be a key cytokine for orchestrating the systemic interaction. These facts argue that rhinosinusitis and asthma are not simply localized disease processes but part of a systemic inflammatory disease affecting the respiratory tract. They also provide a compelling rationale for combined treatment strategies with consideration of the treatment of rhinosinusitis as a means of improving asthma control and monitoring for signs of bronchial involvement in those with rhinosinusitis.
Jani
Alpa Laheri
AL
Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Hamilos
Daniel L
DL
D001249:Asthma / Q000453:epidemiology* / Q000503:physiopathology; D002986:Clinical Trials as Topic; D015897:Comorbidity; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D012137:Respiratory System / Q000503:physiopathology; D012220:Rhinitis / Q000453:epidemiology* / Q000503:physiopathology; D012307:Risk Factors; D012852:Sinusitis / Q000453:epidemiology* / Q000503:physiopathology