title: Incidence of axillary recurrence in 113 sentinel node negative breast cancer patients: a 3-year follow-up study.
abstract: OBJECTIVE
  This study evaluates the 3-year follow-up period and recurrence rate in patients with a negative sentinel node biopsy (SNB) without an additional axillary dissection (ALND).
  
  
  METHODS
  Between January 2000 and March 2002, 197 patients with an invasive breast cancer and clinically negative axillary nodes underwent a sentinel node biopsy. One hundred and thirteen patients were included in our study. The follow-up consisted of clinical examination every 3 months in the first year, followed by every 6 months after the first year. A mammography was obtained annually. Attention was paid to loco-regional recurrence, including axillary recurrence, and distant metastases.
  
  
  RESULTS
  The mean duration of follow-up was 37.5 months (range 24-54). In this period, one patient was diagnosed with an axillary recurrence and one patient developed a supraclavicular lymph node metastasis. Two patients developed a second primary breast cancer in the contralateral breast. No patients were diagnosed with distant metastasis.
  
  
  CONCLUSIONS
  These 3 year follow-up results suggest that SNB is a procedure with a low clinical recurrence rate, which can replace, when strict criteria are met, ALND if the sentinel node is negative.
authors.affiliation: Department of Surgery, Jeroen Bosch Ziekenhuis, P.O. Box 90153, 5200 ME 's-Hertogenbosch, The Netherlands.
authors.forename: M C
authors.initials: MC
authors.lastname: Kokke
authors.forename: I
authors.initials: I
authors.lastname: Jannink
authors.forename: P C
authors.initials: PC
authors.lastname: Barneveld
authors.forename: J C
authors.initials: JC
authors.lastname: van der Linden
authors.forename: W A H
authors.initials: WA
authors.lastname: Gelderman
authors.forename: J C
authors.initials: JC
authors.lastname: Wissing
authors.forename: K
authors.initials: K
authors.lastname: Bosscha
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001365:Axilla; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery; D008207:Lymphatic Metastasis; D008327:Mammography; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000000981:diagnostic imaging; D009426:Netherlands / Q000453:epidemiology; D012008:Recurrence; D021701:Sentinel Lymph Node Biopsy