title: Abdominoperineal excision of male lower urinary tract for synchronous adenocarcinoma of urethra and urinary bladder.
abstract: Urethral adenocarcinoma is the least common histologic subtype of a rare primary carcinoma of the male urethra. Its site of origin remains speculative. The scarcity of reported cases in the literature makes it difficult to define the optimal management. This report is of a 40-year-old morbidly obese man with synchronous adenocarcinoma of the bulbar urethra and bladder, treated surgically by en bloc abdominoperineal penoprostatocystectomy. The pleural recurrence, after a disease-free period of 2 years, responded well to platinum-docetaxel-based systemic chemotherapy. Synchronous occurrence of adenocarcinoma of the urethra and bladder has not been previously reported. This case also highlights the possible role of upcoming adjuvant chemotherapeutic agents.
authors.affiliation: Department of Surgery, The Aga Khan University, Karachi, Pakistan.
authors.forename: Nazim Ali
authors.initials: NA
authors.lastname: Ahmad
authors.forename: Amanullah
authors.initials: A
authors.lastname: Memon
authors.forename: Akbar
authors.initials: A
authors.lastname: Hussainy
mesh_terms: D000005:Abdomen; D000230:Adenocarcinoma / Q000601:surgery*; D000328:Adult; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000601:surgery*; D010502:Perineum; D014523:Urethral Neoplasms / Q000601:surgery*; D001749:Urinary Bladder Neoplasms / Q000601:surgery*; D013520:Urologic Surgical Procedures / Q000379:methods