title: Dominicin, a cyclic octapeptide, and laughine, a bromopyrrole alkaloid, isolated from the Caribbean marine sponge Eurypon laughlini.
abstract: Dominicin, a new cyclic peptide, and the new bromopyrrole alkaloid laughine (4) have been isolated from the marine sponge Eurypon laughlini collected in Dominica. The structures of 1 and 4 were determined by a combination of spectroscopic analysis and chemical degradation. Single-crystal X-ray diffraction analysis confirmed the structure of dominicin (1).
authors.affiliation: Department of Chemistry, University of British Columbia, Vancouver, B.C., Canada, V6T 1Z1.
authors.forename: David E
authors.initials: DE
authors.lastname: Williams
authors.forename: Brian O
authors.initials: BO
authors.lastname: Patrick
authors.forename: Hans W
authors.initials: HW
authors.lastname: Behrisch
authors.forename: Rob
authors.initials: R
authors.lastname: Van Soest
authors.forename: Michel
authors.initials: M
authors.lastname: Roberge
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Andersen
mesh_terms: D000470:Alkaloids; D000818:Animals; D018360:Crystallography, X-Ray; D019424:Dominica; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification*; D011161:Porifera / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000470:Alkaloids; D010456:Peptides, Cyclic; D011758:Pyrroles; C499562:dominicin; C499563:laughine