Effect of tocopherol-monoglucoside (TMG), a water-soluble glycosylated derivate of vitamin E, on hematopoietic recovery in irradiated mice.
A preparation of alpha-tocopherol monoglucoside (TMG) administered i.p. at a dose of 600 mg/kg immediately after whole body gamma irradiation was examined for its radioprotective efficacy towards bone marrow and peripheral blood nucleated cells. When mice received X-rays at a dose of 5,6 Gy, a marked decrease in bone marrow karyocytes and a reduction of peripheral leukocytes within the early post-irradiated period were observed. However these changes were attenuated in TMG-treated mice. Significant protection of blood lymphocytes was found for the TMG group of mice. The return to normal value of the reduced blood leukocyte count starting from the 8th day was more rapid in TMG-treated mice than in untreated irradiated mice. TMG administration was found to enhance hematopoietic recovery, as measured by the exceeded nucleated bone marrow cell count due to elevated amount of both lymphoid and granulocytic elements in the TMG-group, in comparison with that of both control irradiated and non-irradiated animals. These findings indicate that the radioprotective effect of TMG is apparently realized through its influence on hematopoietic system.
Cherdyntseva
Nadezda
N
Cancer Research Institute of Tomsk Scientific Centre of Russian Acad. Med. Sci, Tomsk, Russia. oncology@info.tsu.ru
Shishkina
Anna
A
Butorin
Ivan
I
Murase
Hironobu
H
Gervas
Polina
P
Kagiya
Tsutomu V
TV
D000818:Animals; D001772:Blood Cell Count; D001854:Bone Marrow Cells / Q000187:drug effects / Q000528:radiation effects; D002478:Cells, Cultured; D005720:Gamma Rays / Q000009:adverse effects*; D005960:Glucosides / Q000008:administration & dosage*; D006410:Hematopoiesis / Q000187:drug effects* / Q000528:radiation effects*; D007274:Injections, Intraperitoneal; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051379:Mice; D011836:Radiation Tolerance / Q000187:drug effects; D011837:Radiation-Protective Agents / Q000008:administration & dosage; D020127:Recovery of Function / Q000187:drug effects* / Q000528:radiation effects*; D024505:Tocopherols / Q000008:administration & dosage*
D005960:Glucosides; D011837:Radiation-Protective Agents; C460320:tocopherol monoglucoside; D024505:Tocopherols