title: Asymmetric synthesis of novel tetrahydroquinoline derivatives with a sugar building block and their bioactivities.
abstract: Some novel spiro-tetrahydroquinolines were stereoselectively synthesized by using keto-sugar derived from sucrose as a building block in one pot under mild conditions. The in vitro immunobiological activity and cytotoxicity of these novel tetrahydroquinolines were investigated. The results implied that these spiro-compounds have obvious bioactivity and may be structurally modified to improve bioactivity further.
authors.affiliation: Department of Chemistry, Zhengzhou University, 75, Daxue Road, Zhengzhou 450052, PR China. liuhm@public.zz.ha.cn
authors.forename: Hong-Min
authors.initials: HM
authors.lastname: Liu
authors.forename: Feng-Wu
authors.initials: FW
authors.lastname: Liu
authors.forename: Da-Peng
authors.initials: DP
authors.lastname: Zou
authors.forename: Gui-Fu
authors.initials: GF
authors.lastname: Dai
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002241:Carbohydrates / Q000737:chemistry*; D045744:Cell Line, Tumor; D003500:Cyclization; D006801:Humans; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D002241:Carbohydrates; D011804:Quinolines