title: Increased nasal airflow with budesonide compared with desloratadine during the allergy season.
abstract: OBJECTIVE
  To compare the effects of desloratadine, an H1-blocking antihistamine, and budesonide, an intranasal corticosteroid, on nasal peak inspiratory flow (NPIF) in patients with seasonal allergic rhinitis.
  
  
  METHODS
  We performed a randomized, double-blind, double-dummy, parallel study comparing oral desloratadine, 5 mg/d (n = 31), and budesonide, 32 mug/d per nostril (n = 30), for 2 weeks during the spring allergy season.
  
  
  METHODS
  Subjects recorded NPIF and nasal symptoms twice daily. Baseline measurements were obtained before initiation of treatment. The Rhinoconjunctivitis Quality of Life Questionnaire was completed at baseline and after treatment.
  
  
  RESULTS
  Desloratadine and budesonide caused a significant increase in NPIF compared with baseline on the evening of the first dose (P < .01). Budesonide, however, led to a significantly greater increase in NPIF than did desloratadine when the change from baseline was compared for the entire treatment period (median, 475 vs 150 L/min; P = .01). Both treatments resulted in clinically significant reductions of the individual domains and overall scores on the Rhinoconjunctivitis Quality of Life Questionnaire (P < .01). There was a significant reduction in total symptom scores (P < or = .01) compared with baseline during all treatment days in both treatment groups, with no statistically significant differences between treatments (median, -60.0 vs -59.5; P = .67).
  
  
  CONCLUSIONS
  Both treatments led to significant improvements in NPIF, but the improvement was greater with the intranasal corticosteroid. Both treatments improved quality of life and reduced symptoms. The difference between the objective and subjective outcomes probably reflects the small sample size, the low pollen counts for the season, and the greater variability in subjective compared with objective measures.
authors.affiliation: Section of Otolaryngology-Head and Neck Surgery, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Bhatia
authors.forename: Fuad M
authors.initials: FM
authors.lastname: Baroody
authors.forename: Marcy
authors.initials: M
authors.lastname: deTineo
authors.forename: Robert M
authors.initials: RM
authors.lastname: Naclerio
mesh_terms: D000281:Administration, Intranasal; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D019819:Budesonide / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017336:Loratadine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011336:Probability; D012123:Pulmonary Ventilation / Q000187:drug effects*; D011788:Quality of Life; D015656:Respiratory Mechanics; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis* / Q000188:drug therapy*; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
chemical_list: D019819:Budesonide; D017336:Loratadine; C121345:desloratadine