Synthesis and in vivo antihyperglycemic activity of 5-(1H-pyrazol-3-yl)methyl-1H-tetrazoles.
A series of 5-[(5-aryl-1H-pyrazol-3-yl)methyl]-1H-tetrazoles 3a-h have been synthesized and evaluated for their in vivo antihyperglycemic activity. Some of the synthesized compounds have shown significant glucose lowering activity in male Sprague-Dawley rats in sucrose loaded model. These compounds were also evaluated for their peroxisome proliferator activated receptor gamma agonistic property, but none of them displayed any significant activity.
Sharon
Ashoke
A
Division of Molecular and Structural Biology, Central Drug Research Institute, Lucknow 226001, India.
Pratap
Ramendra
R
Tiwari
Priti
P
Srivastava
Arvind
A
Maulik
P R
PR
Ram
Vishnu Ji
VJ
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013395:Sucrose / Q000008:administration & dosage; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D011720:Pyrazoles; D013777:Tetrazoles; D013395:Sucrose