Asymmetric nickel-catalyzed Negishi cross-couplings of secondary alpha-bromo amides with organozinc reagents.
A Ni/Pybox catalyst achieves the asymmetric cross-coupling of secondary alpha-bromo amides with organozinc reagents. The process tolerates a variety of functional groups and affords the desired product in good yield and in high enantiomeric excess.
Fischer
Christian
C
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Fu
Gregory C
GC
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006842:Hydrocarbons, Brominated / Q000737:chemistry; D009532:Nickel / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D015032:Zinc / Q000737:chemistry*
D000577:Amides; D006842:Hydrocarbons, Brominated; D009942:Organometallic Compounds; D009532:Nickel; D015032:Zinc