Compartmentalization of growth factor receptor signalling.
Spatial and temporal separation of signal transduction pathways often determines the specificity in cellular responses. Recent advances have improved our understanding of how growth factor signalling is influenced by the formation of molecular complexes (signalosomes) in distinct cellular compartments. There has also been new insight into the mechanisms that determine the signalling competence of these complexes and their role in receptor endocytosis, retrograde trafficking in neurons and restricted protein biosynthesis, and many examples have been found where signalosome deregulation leads to disease.
Hoeller
Daniela
D
Institute for Biochemistry II, University Hospital of Goethe University, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany.
Volarevic
Sinisa
S
Dikic
Ivan
I
D000818:Animals; D002451:Cell Compartmentation / Q000502:physiology*; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology; D006133:Growth Substances / Q000378:metabolism*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D046911:Macromolecular Substances / Q000378:metabolism; D021381:Protein Transport / Q000502:physiology; D017978:Receptors, Growth Factor / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D006133:Growth Substances; D047908:Intracellular Signaling Peptides and Proteins; D046911:Macromolecular Substances; D017978:Receptors, Growth Factor