title: Rapid prevention of vertebral fractures associated with osteoporosis.
abstract: Osteoporosis affects postmenopausal women and patients on glucocorticoid therapy. Fractures are the most devastating outcome. Patients who experience an osteoporotic vertebral fracture are at substantial risk of experiencing another within 1 year. Risk can be reduced rapidly with antiresorptives. Risedronate reduced the risk of vertebral fracture in patients with post-menopausal or glucocorticoid-induced osteoporosis after 1 year by up to 71% in prospective studies. In post hoc analyses, significant reductions in clinical vertebral fractures were demonstrated after 6 months with risedronate and 1 year with alendronate and raloxifene. Rapid reduction in fracture risk is achievable with the potent therapeutic agents available.
authors.affiliation: Cedars-Sinai Medical Center/David Geffen School of Medicine at UCLA, Los Angeles, Calif. 90047, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Wallace
mesh_terms: D000368:Aged; D019386:Alendronate / Q000494:pharmacology / Q000627:therapeutic use; D002116:Calcitonin / Q000494:pharmacology / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004164:Diphosphonates / Q000494:pharmacology / Q000627:therapeutic use; D004967:Estrogens / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D000077557:Ibandronic Acid; D007093:Imidazoles / Q000494:pharmacology / Q000627:therapeutic use; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications* / Q000188:drug therapy; D015663:Osteoporosis, Postmenopausal / Q000150:complications / Q000188:drug therapy; D010281:Parathyroid Hormone / Q000494:pharmacology / Q000627:therapeutic use; D012307:Risk Factors; D016103:Spinal Fractures / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome; D000077211:Zoledronic Acid
chemical_list: D004164:Diphosphonates; D004967:Estrogens; D005938:Glucocorticoids; D007093:Imidazoles; D010281:Parathyroid Hormone; D000077211:Zoledronic Acid; D002116:Calcitonin; D000077557:Ibandronic Acid; D019386:Alendronate