title: Correlation of proband and sibling stroke latency: the SWISS Study.
abstract: The authors found a correlation between the age at which probands experience an incident stroke and the age at which their siblings experience an incident stroke (r = 0.68; p < 0.0001). Proband-sibling incident stroke latency correlations were observed in analyses restricted to siblings concordant for smoking (r = 0.68; p < 0.0001), diabetes (r = 0.73; p < 0.0001), and hypertension (r = 0.63; p < 0.0001). In the authors' cohort of affected sibling pairs, inherited factors were important determinants of incident ischemic stroke latency.
authors.affiliation: Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA. Meschia.James@mayo.edu
authors.forename: J F
authors.initials: JF
authors.lastname: Meschia
authors.forename: T G
authors.initials: TG
authors.lastname: Brott
authors.forename: R D
authors.initials: RD
authors.lastname: Brown
authors.forename: B M
authors.initials: BM
authors.lastname: Kissela
authors.forename: J A
authors.initials: JA
authors.lastname: Hardy
authors.forename: W M
authors.initials: WM
authors.lastname: Brown
authors.forename: S S
authors.initials: SS
authors.lastname: Rich
mesh_terms: D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000453:epidemiology* / Q000235:genetics; D015984:Causality; D015331:Cohort Studies; D015897:Comorbidity; D048909:Diabetes Complications / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D035781:Siblings; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D013223:Statistics as Topic; D020521:Stroke / Q000453:epidemiology* / Q000235:genetics