title: Does electroconvulsive therapy (ECT) affect cognitive components of auditory evoked P300?
abstract: Electroconvulsive therapy (ECT), as a treatment tool for psychiatric disorders, is believed to be safe and effective. Nevertheless, it has a negative impact on cognitive functioning, especially on memory, causing both retrograde and anterograde amnesia. However, ECT effects on more subtle stages of information processing are not studied enough. Event-related potentials, and especially P300, are thought to reflect physiology of cognition. Thus, we aimed to evaluate the effects of ECT treatment on parameters of endogenous components (N2, P3) of the P300 potential. Seventeen patients suffering from schizophrenia, schizoaffective disorder and recurrent depressive disorder participated at the study. After the course of ECT, significant increase of N2 amplitude in parietal midline region and prolongation of P3 latency in frontal midline region, of which the magnitude positively correlated with the number of ECT procedures, have been obtained.
authors.affiliation: Department of Biochemistry and Biophysics, Vilnius University, Ciurlionio-21, Vilnius, LT-03101 Lithuania. inga.griskova@gf.vu.lt.
authors.forename: Inga
authors.initials: I
authors.lastname: Griskova
authors.forename: Kastytis
authors.initials: K
authors.lastname: Dapsys
authors.forename: Sergejus
authors.initials: S
authors.lastname: Andruskevicius
authors.forename: Osvaldas
authors.initials: O
authors.lastname: Ruksenas
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000209:etiology* / Q000503:physiopathology; D003866:Depressive Disorder / Q000503:physiopathology / Q000628:therapy; D004565:Electroconvulsive Therapy / Q000009:adverse effects*; D018913:Event-Related Potentials, P300; D005072:Evoked Potentials, Auditory; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000503:physiopathology / Q000628:therapy; D012559:Schizophrenia / Q000503:physiopathology / Q000628:therapy*