Keynote review: epithelial and endothelial barriers in human disease.
There is a spectrum of distinct disease states that have in common their effect of breaking down epithelial and/or endothelial barrier function. Fluid compartmentalization goes awry, with profound implications for epithelial and stromal homeostasis, fluid and/or electrolyte balance, generation of inflammatory states, and even tumor microenvironment. Specific effects on the tight junction are found to be integral to bacterial invasion and tumor progression.
Mullin
James M
JM
Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA. mullinj@mlhs.org
Agostino
Nicole
N
Rendon-Huerta
Erika
E
Thornton
James J
JJ
D000818:Animals; D001424:Bacterial Infections / Q000473:pathology / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000473:pathology / Q000503:physiopathology; D004727:Endothelium / Q000503:physiopathology* / Q000648:ultrastructure; D004848:Epithelium / Q000503:physiopathology* / Q000648:ultrastructure; D030342:Genetic Diseases, Inborn / Q000235:genetics; D006706:Homeostasis; D006801:Humans; D007249:Inflammation / Q000276:immunology; D009369:Neoplasms / Q000473:pathology / Q000503:physiopathology; D019108:Tight Junctions / Q000502:physiology; D014777:Virus Diseases / Q000473:pathology / Q000503:physiopathology