Biochemical and clinicopathological changes induced by Bungarus coeruleus venom in a rat model.
Bungarus coeruleus, a common venomous snake allied to the cobra, is responsible for most envenomations in India. This study examines the pathological effects of B. caeruleus venom and the associated biochemical changes in a rat model. Increased serum aspartate aminotransferase (48%), creatine kinase (30%), and lactate dehydrogenase (6%) were detected after a sublethal dose of 25 microg/kg of B. caeruleus venom was injected intramuscularly into rats observed for 180 min. The venom induced hyperglycemia and increased serum alkaline phosphatase (55%) and urea (90%) concentrations, whereas cholesterol and triglycerides remained normal. Histopathological changes in the heart-hemorrhage, multifocal areas of myocardial fiber necrosis-and constriction of blood vessels in the kidney, with congested vessels, hemorrhage and necrosis of proximal tubules, liver congestion, and hemorrhage were found.
Kiran
K Mirajkar
KM
Department of Biochemistry, Karnatak University Dharwad, Karnataka, India.
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Sunil S
SS
Gadag
J R
JR
D000818:Animals; D017838:Bungarus; D004195:Disease Models, Animal; D004546:Elapid Venoms / Q000633:toxicity*; D006943:Hyperglycemia / Q000097:blood / Q000139:chemically induced; D007273:Injections, Intramuscular; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar
D004546:Elapid Venoms