title: New anticancer agents: in vitro and in vivo evaluation.
abstract: The rapid emergence of new anticancer agents is a tremendous challenge for basic, pre-clinical and clinical research to evaluate and eventually integrate these new agents into clinical routine. Standardized, well-established in vitro and in vivo methods are available for the experimental evaluation of new anticancer agents. A step-wise procedure from in vitro to in vivo experiments using non-functional, functional non-clonogenic and, if applicable, clonogenic assays allows reduction of the number of promising agents for further clinical testing.
authors.affiliation: Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology, Fetscherstrasse 74, 01307 Dresden, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Zips
authors.forename: Howard D
authors.initials: HD
authors.lastname: Thames
authors.forename: Michael
authors.initials: M
authors.lastname: Baumann
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004354:Drug Screening Assays, Antitumor / Q000379:methods*; D005069:Evaluation Studies as Topic; D006801:Humans; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000188:drug therapy*; D014183:Transplantation, Heterologous; D014407:Tumor Cells, Cultured; D014410:Tumor Stem Cell Assay / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents