title: Effect of off-pump and on-pump coronary artery bypass grafting on renal function.
abstract: BACKGROUND
  Coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) has the risk of renal dysfunction. The cause of renal dysfunction after CPB is multifactorial, such as nonpulsatile flow, renal hypoperfusion, hypothermia, and duration of CPB. This study compared off-pump technique with on-pump technique on renal function in patients who underwent CABG.
  
  
  METHODS
  Sixty patients with normal preoperative renal functions undergoing CABG were randomly assigned to conventional revascularization with CPB (on-pump) or beating heart revascularization (off-pump). Renal functions were assessed up to 10 days postoperatively.
  
  
  RESULTS
  Creatinine clearance was found to be significantly higher in the off-pump group than in the on-pump group (p<.05). The off-pump group had significantly less increase in creatinine levels when compared with the on-pump group (p<.05). The free water clearance values decreased similarly in both groups; however, the recovery was more prompt in the off-pump group (p<.05). No significant differences were found in the prevalence of postoperative hemodialysis.
  
  
  CONCLUSIONS
  The off-pump technique may provide a positive contribution and sufficient protection on postoperative renal functions in patients undergoing CABG.
authors.affiliation: Department of Anesthesiology, Meram Medical School of Selcuk University, Konya, Turkey. jalecelik@hotmail.com
authors.forename: Jale Bengi
authors.initials: JB
authors.lastname: Celik
authors.forename: Niyazi
authors.initials: N
authors.lastname: Gormus
authors.forename: Ahmet
authors.initials: A
authors.lastname: Topal
authors.forename: Selmin
authors.initials: S
authors.lastname: Okesli
authors.forename: Hasan
authors.initials: H
authors.lastname: Solak
mesh_terms: D000368:Aged; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass / Q000379:methods; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007677:Kidney Function Tests; D008297:Male; D011183:Postoperative Complications / Q000453:epidemiology; D051437:Renal Insufficiency / Q000453:epidemiology / Q000503:physiopathology
chemical_list: D003404:Creatinine