title: [Correlation between APOA gene polymorphism and intracranial aneurysm].
abstract: OBJECTIVE
  To study the correlation between a pentanucleotide repeats (PNR) polymorphism of APOA and the genesis of intracranial aneurysm.
  
  
  METHODS
  Fifty-eight patients with intracranial aneurysms diagnosed by angiography and 58 healthy controls were enrolled in our study. The gene polymorphism of APOA PNR were detected by polymerase chain reaction (PCR) and non-denatured polyacrylamide gels electropherosis (PAGE).
  
  
  RESULTS
  Eight kinds of gene types and 6 kinds of alleles were found in these two groups. There were two sites of sequence variance in the 5' control region of APOA gene, which were significantly different between the patients and controls.
  
  
  CONCLUSIONS
  Correlation may exist between intracranial aneurysm and APOA gene.
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing 100050, China. zhaoyljt@public3.bta.net.cn
authors.forename: Yuan-li
authors.initials: YL
authors.lastname: Zhao
authors.forename: Yu-ming
authors.initials: YM
authors.lastname: Sun
authors.forename: Shuo
authors.initials: S
authors.lastname: Wang
authors.forename: Ji-zong
authors.initials: JZ
authors.lastname: Zhao
authors.forename: Bao-sheng
authors.initials: BS
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D001054:Apolipoproteins A / Q000235:genetics*; D044466:Asian People; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D002532:Intracranial Aneurysm / Q000235:genetics*; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D001054:Apolipoproteins A; D004247:DNA