title: Primary cerebral angiitis containing marked xanthoma cells with massive intraparenchymal involvement--case report--.
abstract: A 27-year-old woman was referred to our hospital with mild disorientation, bilateral abducens nerve palsy, and mild left hemiparesis. Magnetic resonance (MR) imaging revealed diffuse mass lesions resembling malignant glioma in the right frontal intraparenchymal region, with enhancement of multiple meningeal and intraparenchymal nodules. Partial resection of the frontal lesion was performed. Histological examination revealed that the specimens consisted of brain tissue, with marked perivascular infiltration of histiocytes and sheets of xanthomatous cells. The diagnosis was primary cerebral angiitis containing marked xanthoma cells. Steroid therapy was administered over 1 week. MR imaging showed that the remaining lesions resolved gradually, and had disappeared 2 years after surgery. No neurological symptoms or recurrence of the tumor has been observed during the 6-year period since the operation.
authors.affiliation: Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba.
authors.forename: Eiichi
authors.initials: E
authors.lastname: Ishikawa
authors.forename: Koji
authors.initials: K
authors.lastname: Tsuboi
authors.forename: Shingo
authors.initials: S
authors.lastname: Takano
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kimura
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Aoki
authors.forename: Ryota
authors.initials: R
authors.lastname: Mashiko
authors.forename: Michio
authors.initials: M
authors.lastname: Nagata
mesh_terms: D020434:Abducens Nerve Diseases / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D000328:Adult; D002536:Cerebral Arteries / Q000473:pathology* / Q000503:physiopathology; D003221:Confusion / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply* / Q000473:pathology* / Q000503:physiopathology; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D019635:Neurosurgical Procedures; D010291:Paresis / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D035583:Rare Diseases; D013256:Steroids / Q000627:therapeutic use; D016896:Treatment Outcome; D020293:Vasculitis, Central Nervous System / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology; D014973:Xanthomatosis / Q000473:pathology*
chemical_list: D013256:Steroids