title: P53 expression in colorectal carcinoma: the University of Malaya Medical Centre's experience.
abstract: Loss of P53 function is regarded as one of the critical steps in colorectal carcinogenesis. This study determines the P53 expression pattern of colorectal carcinoma in a cohort of 116 local patients. There was no significant relationship between overexpression of P53 with tumour stage (p=-0.209, chi square test) and grade (p=0.877, chi square test). Survival analysis using Kaplan-Meier procedure did not show significant relationship between P53 positivity with overall recurrence-free and survival outcome (p=0.3322 and 0.921 respectively; log rank test). Long-term follow-up may give a better evaluation on the prognostic value of P53 overexpression in colorectal carcinoma.
authors.affiliation: Department of Pathology, Faculty of Medicine, Universiti Malaya Medical Centre, 50603 Kuala Lumpur.
authors.forename: K S K
authors.initials: KS
authors.lastname: Goh
authors.forename: T A
authors.initials: TA
authors.lastname: Ong
authors.forename: S C
authors.initials: SC
authors.lastname: Peh
authors.forename: H L
authors.initials: HL
authors.lastname: Yuen
authors.forename: M
authors.initials: M
authors.lastname: Naicker
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000401:mortality; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008296:Malaysia; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
chemical_list: D016159:Tumor Suppressor Protein p53