[A case of vanishing bile duct syndrome associated with hypersensitivity to allopurinol].
Allopurinol is frequently used for the treatment of hyperuricemia and gout. Sometimes, a life-threatening reaction develops, as is illustrated by the following case report. We describe a 60-year-old male patient who was treated with allopurinol because of asymptomatic hyperuricemia, and he was presented with fever, skin rash, eosinophilia, worsening renal function and vanishing bile duct syndrome. In this report, we discussed vanishing bile duct syndrome as a serious side effect of allopurinol, and we briefly reviewed the etiology, prevention, and treatment modalities for vanishing bile duct syndrome.
Choi
Seong Ho
SH
Department of Internal Medicine, Veterans Hospital, Seoul, Korea.
Yang
Soo Hyun
SH
Song
Young Bong
YB
Kim
Hye Jin
HJ
Seo
Yeoung Tae
YT
Choi
Dong Seog
DS
Moon
Kyoung Hyoub
KH
Byun
Jong Hoon
JH
Yu
Eun Sil
ES
D000493:Allopurinol / Q000009:adverse effects*; D001649:Bile Duct Diseases / Q000209:etiology* / Q000473:pathology; D004342:Drug Hypersensitivity / Q000150:complications*; D006074:Gout Suppressants / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged
D006074:Gout Suppressants; D000493:Allopurinol