title: Argatroban for anticoagulation during cardiopulmonary bypass in an infant.
abstract: Heparin induced thrombocytopenia (HIT) is a rare, but potentially life-threatening complication of heparin therapy. In patients with HIT, alternative means of anticoagulation are necessary. The authors present an infant with HIT who required anticoagulation during cardiopulmonary bypass for tricuspid valve excision in the treatment of bacterial endocarditis. The direct thrombin inhibitor, argatroban, was successfully used. Previous reports regarding the use of argatroban and other nonheparin anticoagulants for anticoagulation are reviewed and suggestions regarding argatroban dosing in infants are presented.
authors.affiliation: Department of Child Health, University of Missouri, Columbia, MO, USA.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Dyke
authors.forename: Pierantonio
authors.initials: P
authors.lastname: Russo
authors.forename: Leila
authors.initials: L
authors.lastname: Mureebe
authors.forename: Joanne
authors.initials: J
authors.lastname: Russo
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Tobias
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000906:Antibodies / Q000032:analysis; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001120:Arginine / Q000031:analogs & derivatives; D002315:Cardiopulmonary Bypass; D004342:Drug Hypersensitivity; D004697:Endocarditis, Bacterial / Q000150:complications / Q000601:surgery; D006493:Heparin / Q000009:adverse effects* / Q000276:immunology; D006529:Hepatomegaly; D006801:Humans; D007223:Infant; D007431:Intraoperative Complications; D008297:Male; D010875:Pipecolic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D013163:Splenomegaly; D013449:Sulfonamides; D013921:Thrombocytopenia / Q000150:complications; D014261:Tricuspid Valve / Q000601:surgery
chemical_list: D000900:Anti-Bacterial Agents; D000906:Antibodies; D000925:Anticoagulants; D010875:Pipecolic Acids; D013449:Sulfonamides; D006493:Heparin; D001120:Arginine; C031942:argatroban