Do elderly systolic heart failure patients benefit from beta blockers to the same extent as the non-elderly? Meta-analysis of >12,000 patients in large-scale clinical trials.
A meta-analysis of all-cause mortality data involving elderly and non-elderly chronic heart failure patients from 5 completed beta-blocker trials revealed that elderly and non-elderly chronic heart failure patients derived considerable prognostic benefit from beta-blocker therapy without a statistically significant difference in mortality reduction between the 2 groups.
Dulin
Brian R
BR
NHMRC Centre of Clinical Research Excellence in Therapeutics, Departments of Epidemiology and Preventive Medicine and Medicine, Monash University, Alfred Hospital, Melbourne, Australia. brian.dulin@aya.yale.edu
Haas
Steven J
SJ
Abraham
William T
WT
Krum
Henry
H
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000367:Age Factors; D000368:Aged; D006333:Heart Failure / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D008875:Middle Aged; D013599:Systole; D016896:Treatment Outcome
D000319:Adrenergic beta-Antagonists