[Gabaergic mechanism of cerebrovascular and neuroprotective effects of afobazole and picamilon].
The role of GABAergic mechanisms in realization of the effects of afobazole and picamilon on the cerebral circulation was studied in rats. It is found that the cerebrovascular effect of afobazole significantly decreases on the background of the GABA receptor antagonists bicuculline and picrotoxin. This is evidence of an important role of the GABA system in the its cerebrovascular and neuroprotective activity of afobazole. The results of experiments with picamilon showed that the cerebrovascular effect of this drug is not affected by receptor blocking with bicucullin. However, the blocking of chloride channels of the GABA receptors by picrotoxin significantly decreased the effect of picamilon on the cerebral blood flow.
Silkina
I V
IV
Gan'shina
T C
TC
Seredin
S B
SB
Mirzoian
R S
RS
D000700:Analgesics / Q000008:administration & dosage*; D000818:Animals; D001562:Benzimidazoles / Q000008:administration & dosage*; D001640:Bicuculline / Q000008:administration & dosage; D002531:Cerebellum / Q000098:blood supply* / Q000378:metabolism; D018756:GABA Antagonists / Q000008:administration & dosage; D009025:Morpholines / Q000008:administration & dosage*; D010852:Picrotoxin; D051381:Rats; D018079:Receptors, GABA / Q000378:metabolism*; D012039:Regional Blood Flow / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage* / Q000031:analogs & derivatives*
D000700:Analgesics; D001562:Benzimidazoles; D001640:Bicuculline; D018756:GABA Antagonists; D009025:Morpholines; D010852:Picrotoxin; D018079:Receptors, GABA; D005680:gamma-Aminobutyric Acid; C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; C044905:nicotinoyl-GABA