A structurally diverse heterocyclic library: a benzothiazepine-fused beta-lactam library derived from reaction of 2,3-dihydro-1,5-benzothiazepines and acyl chlorides: synthesis and stereochemistry.
A 1H-azeto[2,1-d][1,5]benzothiazepin-1-one, beta-lactam derivatives of dihydrobenzothiazepines library derived from reactions of 2,4-disubstituted 2,3-dihydro-1,5-benzothiazepines and acyl chlorides, including phthalimidoacetyl chloride, chloroacetyl chloride, dichloroacetyl chloride and phenoxyacetyl chloride, was built up through parallel solution-phase synthesis. Stereochemistry of 1H-azeto[2,1-d][1,5]benzothiazepin-1-ones in the reaction process is discussed.
Xu
Jiaxi
J
Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China. jxxu@pku.edu.cn
D001581:Benzothiadiazines / Q000138:chemical synthesis / Q000737:chemistry; D002712:Chlorides / Q000737:chemistry; D002855:Chromatography, Thin Layer; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis* / Q000737:chemistry*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008958:Models, Molecular; D008968:Molecular Conformation; D017550:Spectroscopy, Fourier Transform Infrared; D047090:beta-Lactams / Q000138:chemical synthesis* / Q000737:chemistry*
D001581:Benzothiadiazines; D002712:Chlorides; D006574:Heterocyclic Compounds, 2-Ring; D007202:Indicators and Reagents; D047090:beta-Lactams