title: Logic functions of the genomic cis-regulatory code.
abstract: cis-Regulatory modules that control developmental gene expression process the regulatory inputs provided by the transcription factors for which they contain specific target sites. A prominent class of cis-regulatory processing functions can be modeled as logic operations. Many of these are combinatorial because they are mediated by multiple sites, although others are unitary. In this work, we illustrate the repertoire of cis-regulatory logic operations, as an approach toward a functional interpretation of the genomic regulatory code.
authors.affiliation: Applied Biosystems/Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA.
authors.forename: Sorin
authors.initials: S
authors.lastname: Istrail
authors.forename: Eric H
authors.initials: EH
authors.lastname: Davidson
mesh_terms: D000818:Animals; D001665:Binding Sites / Q000235:genetics; D015815:Cell Adhesion Molecules / Q000235:genetics; D004247:DNA / Q000235:genetics / Q000378:metabolism; D004330:Drosophila / Q000196:embryology / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D020868:Gene Silencing; D005809:Genes, Regulator; D005815:Genetic Code; D016678:Genome; D016015:Logistic Models; D008957:Models, Genetic; D009875:Operator Regions, Genetic; D011506:Proteins / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D012617:Sea Urchins / Q000196:embryology / Q000235:genetics; D015398:Signal Transduction
chemical_list: D015815:Cell Adhesion Molecules; D011506:Proteins; D012097:Repressor Proteins; C061515:endo16 protein, sea urchin; D004247:DNA