title: Synthesis and in vitro antitumor activity of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains.
abstract: A series of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains were synthesized and tested for their in vitro antitumor activity against human myelogenous leukemia K562 cells. Among them, (3,4-dihydro-2-methyl-4-oxoquinazolin-6-yl)methyl 4-(4-fluorophenyl)piperazine-1-carbodithioate 8q exhibited significant inhibitory activity against K562 cells with IC(50) value of 0.5 microM.
authors.affiliation: Department of Chemistry, Capital Normal University, Beijing 100037, China. caoshengli@tsinghua.org.cn
authors.forename: Sheng-Li
authors.initials: SL
authors.lastname: Cao
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Feng
authors.forename: Yu-Yang
authors.initials: YY
authors.lastname: Jiang
authors.forename: Shi-Ying
authors.initials: SY
authors.lastname: Liu
authors.forename: Guo-Yu
authors.initials: GY
authors.lastname: Ding
authors.forename: Run-Tao
authors.initials: RT
authors.lastname: Li
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D020014:K562 Cells; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology; D052999:Quinazolinones; D013329:Structure-Activity Relationship; D013859:Thiocarbamates / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D011799:Quinazolines; D052999:Quinazolinones; D013859:Thiocarbamates; C061339:4-hydroxyquinazoline