title: Relationship between paraoxonase-1 (PON1) activity and lipoprotein (a) levels in Turkish coronary artery disease patients living in the Antalya region.
abstract: BACKGROUND
  Turkish adults have a high incidence of coronary artery disease (CAD).
  
  
  METHODS
  The role of lipoprotein(a) (Lp[a]) as a risk factor for CAD and its association with paraoxonase-1 (PON1) activity and lipid peroxidation indicators were evaluated in Turkish subjects living in Antalya.
  
  
  METHODS
  Paraoxonase-1 activity, Lp(a), conjugated dienes (CD) and thiobarbituric acid-reactive substances (TBARS) levels were measured in 45 healthy controls and 72 CAD patients.
  
  
  RESULTS
  In CAD patients, decreased PON1 activity and increased Lp(a), CD and TBARS levels were observed. Risk factors associated with CAD included TBARS, age and CD.
  
  
  CONCLUSIONS
  Our results indicate an association between PON1 activity and Lp(a) level in CAD patients.
authors.affiliation: Departments of aBiochemistry bCardiology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
authors.forename: Yeşim A
authors.initials: YA
authors.lastname: Göçmen
authors.forename: Ender
authors.initials: E
authors.lastname: Semiz
authors.forename: Saadet
authors.initials: S
authors.lastname: Gümüşlü
mesh_terms: D043303:Aryldialkylphosphatase / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D016022:Case-Control Studies; D003327:Coronary Disease / Q000097:blood* / Q000453:epidemiology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015994:Incidence; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D011336:Probability; D011379:Prognosis; D012016:Reference Values; D018570:Risk Assessment; D012424:Rural Population; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis*; D014421:Turkey / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D017270:Lipoprotein(a); D017392:Thiobarbituric Acid Reactive Substances; D043303:Aryldialkylphosphatase