[The genotypic profiles of Candida albicans isolates from patients with oral lichen planus].
OBJECTIVE
The aim of this study was to investigate the genotypic profiles of Candida albicans isolates from erosive oral lichen planus (OLP) and non-erosive OLP.


METHODS
A total of 112 isolates obtained from healthy control (26), erosive OLP (62) and non-erosive OLP (24) were screened for genotypic profiles by using the randomly amplified polymorphic DNA (RAPD) assay.


RESULTS
RAPD analyses with some random primer reavealed 4 different genotypes among all isolates, and there was significant difference in genotypic constitution between every two groups. Statistically, B and D were the major types in healthy group; A and C were the major types in erosive OLP; A and D were the major types in non-erosive OLP.


CONCLUSIONS
Some Candida albicans isolates with special genotypic profiles may contribute to the development and progression of OLP.
Zeng
Xin
X
Department of Oral Mucosal Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, China.
Chen
Qian-ming
QM
Nie
Min-hai
MH
Li
Bing-qi
BQ
D002176:Candida albicans / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D002180:Candidiasis, Oral / Q000382:microbiology; D005838:Genotype; D006801:Humans; D017676:Lichen Planus, Oral / Q000382:microbiology*; D019105:Random Amplified Polymorphic DNA Technique