Stereocomplex block copolymer micelles: core-shell nanostructures with enhanced stability.
Monodisperse stereocomplex block copolymer micelles were obtained through the self-assembly of equimolar mixtures of poly(ethylene glycol)-block-poly(l-lactide) and poly(ethylene glycol)-block-poly(d-lactide) in water. These micelles possessed partially crystallized cores and mean hydrodynamic diameters ranging from 31 to 56 nm, depending on the lactide content. They exhibited kinetic stability and redispersion properties superior to micelles prepared with isotactic or racemic polymers alone. This study demonstrates the advantages of stereocomplex formation in the design of stabilized water-soluble nanoparticles.
Kang
Ning
N
Canada Research Chair in Drug Delivery, Faculty of Pharmacy and Department of Chemistry, University of Montreal, C.P. 6128 succ. Centre-ville, Montreal, Quebec H3C 3J7, Canada.
Perron
Marie-Eve
ME
Prud'homme
Robert E
RE
Zhang
Yubao
Y
Gaucher
Geneviève
G
Leroux
Jean-Christophe
JC
D003102:Colloids / Q000032:analysis / Q000737:chemistry*; D003460:Crystallization / Q000379:methods*; D007700:Kinetics; D007773:Lactates / Q000032:analysis / Q000737:chemistry*; D008422:Materials Testing; D008823:Micelles; D008968:Molecular Conformation; D049329:Nanostructures / Q000032:analysis / Q000737:chemistry* / Q000648:ultrastructure*; D036103:Nanotechnology / Q000379:methods*; D011092:Polyethylene Glycols / Q000032:analysis / Q000737:chemistry*; D012996:Solutions; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry*
D003102:Colloids; D007773:Lactates; D008823:Micelles; D012996:Solutions; C088513:poly(lactic acid-ethylene glycol); D014867:Water; D011092:Polyethylene Glycols