Semisynthetic preparation of leucomycin derivatives: introduction of aromatic side chains by reductive amination.
A small library of leucomycin A7 derivatives was prepared by NaCNBH3/ZnCl2-mediated reductive amination of the C18 aldehyde moiety with a variety of lipophilic benzylamines and tested for antibiotic activity.
Gebhardt
Peter
P
Hans-Knöll-Institute for Natural Products Research, Beutenbergstr. 11a, 07745 Jena, Germany.
Gräfe
Udo
U
Möllmann
Ute
U
Hertweck
Christian
C
D000447:Aldehydes; D000588:Amines; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007202:Indicators and Reagents; D015939:Kitasamycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010084:Oxidation-Reduction
D000447:Aldehydes; D000588:Amines; D000900:Anti-Bacterial Agents; D007202:Indicators and Reagents; D015939:Kitasamycin