The stress response to sensory contact in mice: genotype effect of the stimulus animal.
Male wild house mice selectively bred for long and short attack latency (LAL and SAL, respectively) were previously shown to respond differently to chronic sensory contact stress with another SAL male. In the present study, it was investigated whether the genotype of the opponent played a role in the differential stress response of LAL and SAL mice. To this end, a LAL or SAL male was housed either under standard conditions (i.e. with a female), single, or in sensory contact with another LAL or SAL male for a period of 5 days. This period was chosen in order to study stress response adaptations. Although social isolation (singly housed) already induced changes in some physiological markers, in particular in LAL mice, the highest number of stress-induced changes was observed in LAL and SAL males living opposite a male of the other genotype. This was indicated in LAL mice by higher corticosterone levels, adrenal hypertrophy, and reduced seminal vesicle weight, and in SAL mice by higher ACTH levels and adrenal hypertrophy. Some mechanisms through which LAL and SAL mice could perceive each other as being different are proposed in the discussion, but it remains unclear why these mice show a differential stress response depending on the genotype of the opponent. In conclusion, it was demonstrated that a psychosocial stressor triggered line-specific changes in LAL and SAL mice, which were shown to be determined by the genotype of the stressor. These results open a new avenue to investigate mechanisms underlying genotypic-dependent stress responses.
Veenema
Alexa H
AH
Department of Animal Physiology, Center for Behavioral and Cognitive Neurosciences, University of Groningen, Groningen, The Netherlands. alexa.veenema@biologie.uni-regensburg.de
Sijtsma
Betty
B
Koolhaas
Jaap M
JM
de Kloet
E Ronald
ER
D000223:Adaptation, Psychological / Q000502:physiology*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000374:Aggression / Q000502:physiology* / Q000523:psychology; D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight / Q000502:physiology; D003345:Corticosterone / Q000097:blood; D004291:Dominance-Subordination; D005260:Female; D006799:Housing, Animal; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011930:Reaction Time / Q000235:genetics*; D012931:Social Environment; D013045:Species Specificity; D013315:Stress, Psychological / Q000097:blood / Q000235:genetics* / Q000523:psychology
D000324:Adrenocorticotropic Hormone; D003345:Corticosterone