title: Cognitive and behavioral assessment in dogs and pet food market applications.
abstract: A multi-disciplinary program was developed to assess the efficacy of antioxidant inclusion in a canine pet food on cognitive decline in aged beagles. A systematic approach to development of the food was used prior to beginning the cognitive studies. Comprehensive evaluation of antioxidant ingredients included assessments of commodities with naturally occurring antioxidants and synthetic antioxidants not commonly utilized, or at different concentrations than what was commonly utilized, in commercial pet foods. Studies were conducted to insure stability through processing, absorption from the gastrointestinal tract, safety, and tests for potential antioxidant biological benefit by ex vivo tests. Testing of the antioxidant-fortified food in aged beagles slowed the rate of cognitive decline in aged dogs. In addition, environmental enrichment also slowed the rate of cognitive decline. Importantly, the combination of dietary antioxidants and environmental enrichment was synergistic and resulted in the least amount of cognitive decline over the 30-month study period. Finally, a clinical study showed that antioxidant fortified food improved age-related behavioral changes in older pet dogs at in-home situations.
authors.affiliation: Hill's Pet Nutrition, Inc., Science and Technology Center, PO Box 1658, Topeka, KS 66601-1658, USA. Steven_Zicker@hillspet.com
authors.forename: Steven C
authors.initials: SC
authors.lastname: Zicker
mesh_terms: D000375:Aging / Q000187:drug effects; D000818:Animals; D000975:Antioxidants / Q000191:economics* / Q000494:pharmacology; D001522:Behavior, Animal / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005527:Food, Fortified; D058870:Food, Organic; D007858:Learning / Q000187:drug effects / Q000502:physiology; D040541:Marketing
chemical_list: D000975:Antioxidants