title: Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function.
abstract: Hepcidin, a key regulator of iron metabolism, is synthesized by the liver. Hepcidin binds to the iron exporter ferroportin to regulate the release of iron into plasma from macrophages, hepatocytes, and enterocytes. We analyzed liver samples from patients undergoing hepatic surgery for cancer or receiving liver transplants and analyzed correlations between clinical parameters and liver hepcidin mRNA and urinary hepcidin concentrations. Despite the many potential confounding influences, urinary hepcidin concentrations significantly correlated with hepatic hepcidin mRNA concentrations, indicating that hepcidin quantification in urine is a valid approach to evaluate hepcidin expression. Moreover, we found in humans that hepcidin levels correlated with hepatic iron stores and hemoglobin levels and may also be affected by hepatic dysfunction.
authors.affiliation: Institut National de la Sante et de la Recherche Medicale, Rennes, France.
authors.forename: Lénaïck
authors.initials: L
authors.lastname: Détivaud
authors.forename: Elizabeta
authors.initials: E
authors.lastname: Nemeth
authors.forename: Karim
authors.initials: K
authors.lastname: Boudjema
authors.forename: Bruno
authors.initials: B
authors.lastname: Turlin
authors.forename: Marie-Bérengère
authors.initials: MB
authors.lastname: Troadec
authors.forename: Patricia
authors.initials: P
authors.lastname: Leroyer
authors.forename: Martine
authors.initials: M
authors.lastname: Ropert
authors.forename: Sylvie
authors.initials: S
authors.lastname: Jacquelinet
authors.forename: Brice
authors.initials: B
authors.lastname: Courselaud
authors.forename: Tomas
authors.initials: T
authors.lastname: Ganz
authors.forename: Pierre
authors.initials: P
authors.lastname: Brissot
authors.forename: Olivier
authors.initials: O
authors.lastname: Loréal
mesh_terms: D000328:Adult; D000368:Aged; D023181:Antimicrobial Cationic Peptides / Q000235:genetics* / Q000652:urine*; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D064451:Hepcidins; D006801:Humans; D008099:Liver / Q000502:physiology*; D008103:Liver Cirrhosis / Q000235:genetics / Q000503:physiopathology / Q000652:urine; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
chemical_list: D023181:Antimicrobial Cationic Peptides; C578702:HAMP protein, human; D006454:Hemoglobins; D064451:Hepcidins; D012333:RNA, Messenger; D004247:DNA