title: The influence of aromatic residues in hydraphile spacer units: assay by ion selective electrode methods and in bacteria.
abstract: A small library of hydraphiles has been prepared that incorporates either 1,4-phenylenedioxy or 2,6-naphthalenedioxy within the spacer chains. The side chains attached to the distal macrocycles in these tris(macrocyclic) compounds are either n-dodecyl or benzyl. The presence of the arenes subunits significantly affect sodium cation release from vesicles. The efficacy of ion transport is paralleled by the toxicity of these compounds to Bacillus subtilis.
authors.affiliation: Department of Chemistry, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8103, St. Louis, MO 63110, USA.
authors.forename: Adam E
authors.initials: AE
authors.lastname: Meyer
authors.forename: W Matthew
authors.initials: WM
authors.lastname: Leevy
authors.forename: Robert
authors.initials: R
authors.lastname: Pajewski
authors.forename: Iwao
authors.initials: I
authors.lastname: Suzuki
authors.forename: Michelle E
authors.initials: ME
authors.lastname: Weber
authors.forename: George W
authors.initials: GW
authors.lastname: Gokel
mesh_terms: D001412:Bacillus subtilis / Q000187:drug effects* / Q000254:growth & development; D002412:Cations / Q000737:chemistry / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D006841:Hydrocarbons, Aromatic / Q000737:chemistry* / Q000633:toxicity; D017736:Ion-Selective Electrodes; D015394:Molecular Structure; D010743:Phospholipids / Q000737:chemistry; D012964:Sodium / Q000737:chemistry / Q000378:metabolism; D013997:Time Factors
chemical_list: D002412:Cations; D006841:Hydrocarbons, Aromatic; D010743:Phospholipids; D012964:Sodium