title: Transformations of steroids by Beauveria bassiana.
abstract: The course of transformations of testosterone and its derivatives, including compounds with an additional C1,C2 double bond and/or a 17alpha-methyl group, a 17beta-acetyl group or without a 19-methyl group, by a Beauveria bassiana culture was investigated. The fungi promoted hydroxylation of these compounds at position 11alpha, oxidation of the 17beta-hydroxyl group, reduction of the C1,C2 or C4,C5 double bonds and degradation of the progesterone side-chain, leading to testosterone. The structure of 4-ene-3-oxo-steroids had no influence on regio- and stereochemistry of hydroxylation. In a similar manner, dehydroepiandrosterone was hydroxylated by Beauveria bassiana at position 11alpha, however, a small amount of 7alpha-hydroxylation product was also formed.
authors.affiliation: Department of Chemistry, Agricultural University, Norwida 25, 50-375 Wrocław, Poland. huszcza@ozi.ar.wroc.pl
authors.forename: Ewa
authors.initials: E
authors.lastname: Huszcza
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Dmochowska-Gładysz
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Bartmańska
mesh_terms: D001203:Ascomycota / Q000378:metabolism*; D001711:Biotransformation; D008958:Models, Molecular; D008968:Molecular Conformation; D013256:Steroids / Q000493:pharmacokinetics*; D013739:Testosterone / Q000031:analogs & derivatives / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D013256:Steroids; D013739:Testosterone