title: "Proximal-type" and classic epithelioid sarcomas represent a clinicopathologic continuum: case report.
abstract: We report a case of an epithelioid sarcoma that occurred in the right hand of a 14-year-old boy and had the "proximal-type" morphology and a complex, near-tetraploid karyotype. The tumor metastasized to the lungs, where the morphology was typical for the classic epithelioid sarcoma. Based on the morphologic and cytogenetic findings in this case, we suggest that the proximal-type and the classic epithelioid sarcomas are not distinct entities but represent a continuum.
authors.affiliation: Department of Pathology, Children's Medical Center of Dallas, 1935 Motor Street, Dallas, TX 75235, USA.
authors.forename: Dinesh
authors.initials: D
authors.lastname: Rakheja
authors.forename: Kathleen S
authors.initials: KS
authors.lastname: Wilson
authors.forename: John
authors.initials: J
authors.lastname: Meehan
authors.forename: Roger A
authors.initials: RA
authors.lastname: Schultz
authors.forename: Ana M
authors.initials: AM
authors.lastname: Gomez
mesh_terms: D000293:Adolescent; D000782:Aneuploidy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D017024:Chemotherapy, Adjuvant; D003520:Cyclophosphamide / Q000627:therapeutic use; D005047:Etoposide / Q000627:therapeutic use; D006225:Hand; D006801:Humans; D007124:Immunoenzyme Techniques; D017403:In Situ Hybridization; D008175:Lung Neoplasms / Q000235:genetics / Q000556:secondary / Q000628:therapy; D008297:Male; D012509:Sarcoma / Q000737:chemistry / Q000235:genetics / Q000556:secondary* / Q000628:therapy; D012983:Soft Tissue Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D032681:Spectral Karyotyping
chemical_list: D014408:Biomarkers, Tumor; D005047:Etoposide; D003520:Cyclophosphamide