title: Working memory processing of facial images in schizophrenia: fMRI investigation.
abstract: Impaired processing of facial information is one of the broad ranges of cognitive deficits seen in patients with schizophrenia. This study aimed to elucidate the differences in brain activities involved in the process of facial working memory (images of neutral faces as mnemonic content) between schizophrenic patients and healthy comparison subjects using functional magnetic resonance imaging (fMRI). Group comparison analysis revealed aberrant activities from the patient group in several cortical areas, including the left fusiform gyrus, right superior frontal gyrus, bilateral middle frontal gyri/insula, and left middle temporal gyrus. A decreased level of activity in the left fusiform gyrus, along with performance reduction, implicates abnormal processing of facial information in schizophrenia.
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02446, USA.
authors.forename: Seung-Schik
authors.initials: SS
authors.lastname: Yoo
authors.forename: Byung-Gil
authors.initials: BG
authors.lastname: Choi
authors.forename: Ra-Hyeong
authors.initials: RH
authors.lastname: Juh
authors.forename: Joo-Mi
authors.initials: JM
authors.lastname: Park
authors.forename: Chi-Un
authors.initials: CU
authors.lastname: Pae
authors.forename: Jung-Jin
authors.initials: JJ
authors.lastname: Kim
authors.forename: Soo-Jung
authors.initials: SJ
authors.lastname: Lee
authors.forename: Chul
authors.initials: C
authors.lastname: Lee
authors.forename: In-Ho
authors.initials: IH
authors.lastname: Paik
authors.forename: Chang-Uk
authors.initials: CU
authors.lastname: Lee
mesh_terms: D000328:Adult; D001931:Brain Mapping; D005145:Face; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D010296:Parietal Lobe / Q000503:physiopathology; D010364:Pattern Recognition, Visual / Q000502:physiology*; D012044:Regression Analysis; D012559:Schizophrenia / Q000503:physiopathology*