title: Functional heme oxygenase-1 promoter polymorphism in relation to heart failure and cardiac transplantation.
abstract: We investigated the functional promoter repeat polymorphism (GT)(n) in the oxidative stress-induced enzyme heme oxygenase-1 in relation to heart failure and complications after transplantation. No influence of the polymorphism on the development of heart failure, graft survival, acute rejection, or transplant atherosclerosis was found.
authors.affiliation: Department of Internal Medicine, University Medical Center Rotterdam, Rotterdam, The Netherlands. cholweg@cvmed.stanford.edu
authors.forename: Cecile T J
authors.initials: CT
authors.lastname: Holweg
authors.forename: Aggie H M M
authors.initials: AH
authors.lastname: Balk
authors.forename: André G
authors.initials: AG
authors.lastname: Uitterlinden
authors.forename: Hubert G M
authors.initials: HG
authors.lastname: Niesters
authors.forename: Lex P W M
authors.initials: LP
authors.lastname: Maat
authors.forename: Willem
authors.initials: W
authors.lastname: Weimar
authors.forename: Carla C
authors.initials: CC
authors.lastname: Baan
mesh_terms: D000328:Adult; D001706:Biopsy; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis / Q000235:genetics; D003331:Coronary Vessels / Q000473:pathology; D004247:DNA / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006084:Graft Rejection / Q000235:genetics; D006085:Graft Survival / Q000235:genetics; D006333:Heart Failure / Q000097:blood* / Q000601:surgery; D016027:Heart Transplantation / Q000009:adverse effects; D006419:Heme Oxygenase (Decyclizing) / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D016133:Polymerase Chain Reaction; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012189:Retrospective Studies; D012307:Risk Factors; D014019:Tissue Donors
chemical_list: D004247:DNA; D006419:Heme Oxygenase (Decyclizing)