Repeated stress alters caffeine action on motor coordination in C57Bl6/J male mice.
This study was aimed to evaluate the effects of stress on caffeine action on motor coordination in mice. For 6 consecutive days, the mice were subjected to three different stressors. Saline or caffeine (30, 60 or 120 mg kg(-1)) was i.p. administered after the last stressful experience, then the animals were behaviorally tested in the holeboard. Their stumbling frequency was compared to that of unstressed mice injected with either saline or caffeine. (1) There was a strong trend for stress to impair motor coordination. (2) In unstressed mice, caffeine induced a linear dose-dependent increase of stumbling frequency. (3) Stress decreased the stumbling frequency induced by the highest dose of caffeine. The results are discussed in terms of interaction of stress and caffeine on dopaminergic and GABAergic systems.
Meyer
L
L
Laboratoire PSY.CO, UPRES EA 1780, Equipe Plasticité Cérébrale, Faculté des Sciences-Université de Rouen, 76821 Mont-Saint-Aignan Cedex, France. Laurence.Meyer@univ-rouen.fr
Caston
J
J
D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D002908:Chronic Disease; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009048:Motor Skills / Q000187:drug effects*; D013315:Stress, Psychological / Q000503:physiopathology*
D000697:Central Nervous System Stimulants; D002110:Caffeine