title: Dihydrochalcones from the leaves of Pieris japonica.
abstract: Six new dihydrochalcones, 3-hydroxyasebotin (5), asebogenin 2'-O-beta-D-ribohexo-3-ulopyranoside (6), 2' '-acetylasebotin (7), 3',4,5'-trihydroxy-4'-methoxydihydrochalcone 3',5'-di-O-beta-D-glucopyranoside (8), and pierotins A (9) and B (10), along with four known dihydrochalcones, phloretin (1), phlorizin (2), asebogenin (3), and asebotin (4), were isolated from the leaves of Pieris japonica. Their structures were elucidated on the basis of spectroscopic analysis including HMQC, HMBC, NOESY, and X-ray crystal diffraction. Compounds 1, 3-5, and 7-10 inhibited the proliferation of murine B cells and compounds 5 and 10 inhibited the proliferation of murine T cells in vitro significantly.
authors.affiliation: Shanghai Institute of Materia Medica, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
authors.forename: Guang-Min
authors.initials: GM
authors.lastname: Yao
authors.forename: Yu
authors.initials: Y
authors.lastname: Ding
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Zuo
authors.forename: Hong-Bing
authors.initials: HB
authors.lastname: Wang
authors.forename: Yu-Bo
authors.initials: YB
authors.lastname: Wang
authors.forename: Bing-Yang
authors.initials: BY
authors.lastname: Ding
authors.forename: Pauline
authors.initials: P
authors.lastname: Chiu
authors.forename: Guo-Wei
authors.initials: GW
authors.lastname: Qin
mesh_terms: D000818:Animals; D002599:Chalcone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047188:Chalcones; D002681:China; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D029791:Ericaceae / Q000737:chemistry*; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013601:T-Lymphocytes / Q000187:drug effects*
chemical_list: D047188:Chalcones; D002599:Chalcone; C015812:dihydrochalcone