title: Antibiotic tolerance induced by lactoferrin in clinical Pseudomonas aeruginosa isolates from cystic fibrosis patients.
abstract: Lactoferrin-induced cell depolarization and a delayed tobramycin-killing effect on Pseudomonas aeruginosa cells were correlated. This antibiotic tolerance effect (ATE) reflects the ability of a defense protein to modify the activity of an antibiotic as a result of its modulatory effect on bacterial physiology. P. aeruginosa isolates from cystic fibrosis patients showed higher ATE values (< or = 6-fold) than other clinical strains.
authors.affiliation: Laboratory of Oral Microbiology, School of Stomatology, University of Oviedo, Oviedo, Spain.
authors.forename: María T
authors.initials: MT
authors.lastname: Andrés
authors.forename: Mónica
authors.initials: M
authors.lastname: Viejo-Diaz
authors.forename: Francisco
authors.initials: F
authors.lastname: Pérez
authors.forename: José F
authors.initials: JF
authors.lastname: Fierro
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003550:Cystic Fibrosis / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D006801:Humans; D007781:Lactoferrin / Q000494:pharmacology*; D011552:Pseudomonas Infections / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D014031:Tobramycin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D007781:Lactoferrin; D014031:Tobramycin