A novel three-component reaction designed by the combinatorial method: heteroarenes, isothiocyanates and isocyanides.
The novel three-component reaction of isoquinoline with isothiocyanates and isocyanides leads to a variety of new imidazoisoquinolines. The zwitterionic ground state of these new ring systems is established by means of NMR and X-ray analysis. Use of phthalazine instead of isoquinoline gives access to imidazole annulated phthalazines.
Mironov
Maxim A
MA
Department of Technology of Organic Synthesis (TOSLab), Urals State Technical University, 620002 Ekaterinburg, Russian Federation. mir@htf.ustu.ru
Maltsev
Sergey S
SS
Mokrushin
Vladimir S
VS
Bakulev
Vasiliy A
VA
D003486:Cyanides / Q000138:chemical synthesis / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007202:Indicators and Reagents; D007546:Isoquinolines / Q000737:chemistry; D017879:Isothiocyanates / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation
D003486:Cyanides; D006571:Heterocyclic Compounds; D007202:Indicators and Reagents; D007546:Isoquinolines; D017879:Isothiocyanates