title: Fluorescence bronchoscopy for selection of surgical procedure in patients with early staged endobronchial carcinoma.
abstract: BACKGROUND
  It is sometimes difficult to determine the extent of resection in patients with endobronchial carcinoma because preoperative white-light bronchoscopic (WLB) examination is not sensitive enough to examine the extent fully. Light-Induced Fluorescence Endoscopy (LIFE) is recognized as a useful modality for the diagnosis of early staged bronchial carcinoma, but there have been no reports of its significance in surgical treatment. We have studied the influence of LIFE upon the selection of surgical procedures or other treatments in patients with endobronchial carcinoma preoperatively.
  
  
  METHODS
  Conventional WLB and LIFE were performed within 7 days of operation. Biopsy specimens were taken from the marginal regions of the areas that were suspicious for malignancy on LIFE examination and WLB. We decided the resection line before operation and kept the resected central margin 1 cm apart from the area revealed as suspicious by LIFE.
  
  
  RESULTS
  From January 1999 to March 2003, 75 patients underwent LIFE. LIFE was performed to decide the surgical procedures for 12 patients (16.0%). Surgical therapy was performed in 8 (66.7%). LIFE findings dramatically changed the surgical procedures for 3 patients, lobectomy changed to sleeve lobectomy in 2 and laser therapy to segmentectomy in 1. LIFE revealed larger abnormal areas of bronchial cancer compared to WLB in 7 (58.3%). Conversely, WLB overestimated the extent of abnormal area in 1 (8.3%). WLB revealed the same cancer area as LIFE in 4. In all patients, the resected bronchial margins were cancer free intraoperatively and postoperatively.
  
  
  CONCLUSIONS
  LIFE can be more sensitive than WLB and be more beneficial for judging the extent of neoplastic bronchial changes for some patients. LIFE may be a useful modality for the preoperative selection of surgical procedures, especially whether sleeve resection is needed or not, for some centrally located superficial endobronchial carcinoma.
authors.affiliation: Department of General Thoracic Surgery, Ishikawa Prefectural Central Hospital, Karatsuki-higashi 2-1, Kanazawa 920-8530, Japan. tsuney@nifty.com
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Tsunezuka
authors.forename: Makoto
authors.initials: M
authors.lastname: Oda
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Ohta
authors.forename: Isao
authors.initials: I
authors.lastname: Matsumoto
authors.forename: Masaya
authors.initials: M
authors.lastname: Tamura
authors.forename: Go
authors.initials: G
authors.lastname: Watanabe
mesh_terms: D000368:Aged; D001984:Bronchial Neoplasms / Q000473:pathology* / Q000601:surgery; D001999:Bronchoscopy / Q000379:methods*; D002277:Carcinoma / Q000473:pathology* / Q000601:surgery; D005260:Female; D005453:Fluorescence; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018579:Patient Selection; D011013:Pneumonectomy; D015203:Reproducibility of Results