title: Daucane sesquiterpenes from Ferula hermonis.
abstract: The dried roots of Ferula hermonis yielded three new daucanes, (1R,4R)-4-hydroxydauca-7-ene-6-one (1), (1R,4R)-4-hydroxydauca-7-ene-6,9-dione (2), and (1R,3S,8S)-3-ethoxy-8-angeloyloxydauca-4-en-9-one (3), together with the three known sesquiterpenes, ferutinin, teferidin, and (+)-alpha-bisabolol. The structures of compounds 1-3 were elucidated on the basis of spectroscopic evidence. The effect of these compounds on the proliferation of estrogen-dependent MCF-7 cells was evaluated, and it was found that compounds 1 and 3 exhibited proliferative activity, whereas 2 showed an antiproliferative effect.
authors.affiliation: UMR-152 Laboratoire de Pharmacochimie des Substances Naturelles et Pharmacophores Redox, Faculté des Sciences Pharmaceutiques, Université Paul Sabatier, 35 Chemin des Maraîchers, F-31062 Toulouse, France.
authors.forename: Amélie
authors.initials: A
authors.lastname: Lhuillier
authors.forename: Nicolas
authors.initials: N
authors.lastname: Fabre
authors.forename: Edmond
authors.initials: E
authors.lastname: Cheble
authors.forename: Fathi
authors.initials: F
authors.lastname: Oueida
authors.forename: Séverine
authors.initials: S
authors.lastname: Maurel
authors.forename: Alexis
authors.initials: A
authors.lastname: Valentin
authors.forename: Isabelle
authors.initials: I
authors.lastname: Fourasté
authors.forename: Claude
authors.initials: C
authors.lastname: Moulis
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification; D001643:Bridged Bicyclo Compounds; D003508:Cycloheptanes; D004354:Drug Screening Assays, Antitumor; D004967:Estrogens / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005309:Ferula / Q000737:chemistry*; D007861:Lebanon; D015394:Molecular Structure; D000081222:Monocyclic Sesquiterpenes; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001565:Benzoates; D001643:Bridged Bicyclo Compounds; D003508:Cycloheptanes; D004967:Estrogens; D000081222:Monocyclic Sesquiterpenes; D012717:Sesquiterpenes; C004497:bisabolol; C111068:4-oxy-6-(4-oxybezoyloxy)dauc-8,9-en