title: The correlation of the bispectral index with propofol effect site concentrations is not altered by epochs indicated as artefact-loaded by narcotrend.
abstract: OBJECTIVE
  Artefact detection is an essential feature of automatic EEG monitoring systems used in anaesthesia. Clinical experience indicates that Narcotrend monitoring (MonitorTechnik, Bad Bramstedt, Germany, version 4.0) excludes more EEG epochs because of artefacts than bispectral index monitoring (BIS, Aspect Medical Systems, Newton, MA, version XP). Whether this increased exclusion of epochs is justified has not been investigated yet.
  
  
  METHODS
  Eighteen adult patients undergoing radical prostatectomy were investigated. Induction of anaesthesia was performed with a fentanyl bolus and a propofol infusion. Additionally, following intubation patients received 15 ml bupivacaine 0.5% epidurally. After a waiting period of 45 min depth of anaesthesia was varied two times by increasing and decreasing propofol concentrations. Narcotrend index, BIS values and calculated propofol effect site concentrations were automatically recorded at intervals of 5 s. We tested the hypothesis whether exclusion of artefacts detected by the Narcotrend monitor would possibly improve the prediction probability of the BIS monitor, justifying the necessity of artefact suppression.
  
  
  RESULTS
  Simulated propofol effect site concentrations ranged from 2 microg/ml to 6 microg/ml. The Narcotrend monitor excluded a significantly higher percentage of epochs because of artefact detection (12.6 + 1.0%) than the BIS monitor (0.4 +/- 0.1%). The performance of BIS as an indicator of predicted propofol effect site concentrations did not differ when including (P(K) = 0.86 +/- 0.05) or excluding (P(K) = 0.85 +/- 0.04) the data pairs where Narcotrend monitor but not BIS monitor indicated an artefact. Artefacts were evenly distributed over the investigated range ofpropofol effect site concentrations.
  
  
  CONCLUSIONS
  Exclusion of data pairs that were detected as artefacts by Narcotrend but not by BIS did not change the performance of bispectral index as an indicator of propofol effect site concentration.
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Bonn, Germany. richard.ellerkmann@ukb.uni-bonn.de
authors.forename: Richard K
authors.initials: RK
authors.lastname: Ellerkmann
authors.forename: Sascha
authors.initials: S
authors.lastname: Kreuer
authors.forename: Wolfram
authors.initials: W
authors.lastname: Wilhelm
authors.forename: Ingobert
authors.initials: I
authors.lastname: Wenningmann
authors.forename: Heiko
authors.initials: H
authors.lastname: Roepcke
authors.forename: Andreas
authors.initials: A
authors.lastname: Hoeft
authors.forename: Jörgen
authors.initials: J
authors.lastname: Bruhn
mesh_terms: D000368:Aged; D000768:Anesthesia, General / Q000379:methods*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000494:pharmacology*; D016477:Artifacts; D001331:Automation; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D015742:Propofol / Q000008:administration & dosage* / Q000494:pharmacology*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000601:surgery
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol