[Chemical constituents from marine alga Chaetomorpha basiretorsa].
OBJECTIVE
To investigate the chemical constituents of marine alga Chaetomorpha basiretorsa.


METHODS
Compounds were isolated by normal phase silica gel and Sephadex LH-20 gel colum chromatography, reverse phase MPLC, reverse phase HPLC and recrystallization. Their structures were elucidated by spectroscopic methods including MS, IR, NMR, and X-ray crystalography. Cytotoxicity of the compounds were screened by using standard MTT method.


RESULTS
Nine compounds were isolated from C. basiretorsa and their structures were identified as N-phenyl-2-naphthalenamine( I ), dibutyl phthalate( II ), diisobutyl phthalate( III ), 1-phenyl-ethane-1, 2-diol( IV ), 2-hydrox-gamma-benzaldehyde( V ), diethyleneglycol monobenzoate( VI ), uracil( VII ), thymine( VIII ) and thymidine( IX ).


CONCLUSIONS
All these compounds were obtained from this genus for the first time, N-phenyl-2-naphthalenamine and diethyleneglycol monobenzoate were first reported from the marine organisms. Compound I and VII showed moderate activity against KB cell(IC50 10.15 microg x mL(-1) for I and 3.79 microg x mL(-1) for VII ) and MCF-7 cell(IC50 3.24 microg x mL(-1) for VII).
Shi
Da-yong
DY
Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
Han
Li-jun
LJ
Sun
Jie
J
Wang
Ying
Y
Yang
Yong-chun
YC
Shi
Jian-gong
JG
Fan
Xiao
X
D015057:1-Naphthylamine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D000460:Chlorophyta / Q000737:chemistry*; D003460:Crystallization; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D014498:Uracil / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
C505278:N-phenyl-2-naphthalenamine; D014498:Uracil; D015057:1-Naphthylamine