Vascularity and fractal dimension of the dermo-epidermal interface in guttate and plaque-type psoriasis.
BACKGROUND
Histological structures of the skin are often irregular in size and shape. Euclidean geometry and fractal analysis are complementary for assessing distinct aspects of their dimensions.


OBJECTIVE
To determine and compare the variations in shape of the dermo-epidermal junction and the size of the superficial vessels in psoriatic lesions.


METHODS
The relative microvasculature area and the fractal dimension D of the dermo-epidermal interface were measured inside and outside growth-stunted guttate lesions (n = 22) and expanding plaques (n = 37) in psoriasis of the trunk.


RESULTS
The median D values of the dermo-epidermal interface were significantly larger (p < 0.01) in psoriatic plaques (D = 1.15) than in guttate lesions (D = 1.08), and these D values on lesional skin were significantly larger (p < 0.01) than in the uninvolved skin (D = 1.03). The microvasculature was significantly (p < 0.01) more developed in lesional (plaque: 13%, guttate: 8.20%) than in uninvolved skin (3.60 and 3.85%). No correlations were found between the relative microvasculature areas and the D values of the dermo-epidermal interface, both in the uninvolved and lesional skins of each psoriatic type.


CONCLUSIONS
The absence of a relationship between modulations of the dermo-epidermal junction and vascular hyperplasia, both in expanding and stable psoriasis lesions, suggests that these events are regulated by different mechanisms and do not depend on each other.
Uhoda
Isabelle
I
Department of Dermatopathology, University Hospital of Liège, Liège, Belgium.
Piérard
Gérald E
GE
Piérard-Franchimont
Claudine
C
Arrese
Jorge E
JE
Goffin
Véronique
V
Nikkels
Arjen
A
Paquet
Philippe
P
Quatresooz
Pascale
P
D001706:Biopsy; D016022:Case-Control Studies; D006801:Humans; D008833:Microcirculation; D009389:Neovascularization, Pathologic / Q000473:pathology / Q000503:physiopathology*; D011565:Psoriasis / Q000473:pathology / Q000503:physiopathology*; D012867:Skin / Q000098:blood supply*