title: Synthesis and in vitro leishmanicidal activity of 2-(5-nitro-2-furyl) and 2-(5-nitro-2-thienyl)-5-substituted-1,3,4-thiadiazoles.
abstract: A series of 2-(5-nitro-2-furyl) and 2-(5-nitro-2-thienyl)-5-substituted-1,3,4-thiadiazoles (5a-d and 6a-j) were synthesized and evaluated against Leishmania major promastigotes using (3)H-thymidine incorporation. Most of the compounds showed activity better than the reference drug sodium stibogluconate (Pentostam). The most active compound was 6c (IC(50)=0.1 microM).
authors.affiliation: Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman 76351, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Foroumadi
authors.forename: Shirin
authors.initials: S
authors.lastname: Pournourmohammadi
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Soltani
authors.forename: Mitra
authors.initials: M
authors.lastname: Asgharian-Rezaee
authors.forename: Shahriar
authors.initials: S
authors.lastname: Dabiri
authors.forename: Arsalan
authors.initials: A
authors.lastname: Kharazmi
authors.forename: Abbas
authors.initials: A
authors.lastname: Shafiee
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D018320:Leishmania major / Q000187:drug effects* / Q000254:growth & development*; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000981:Antiprotozoal Agents; D013830:Thiadiazoles