title: Absence or decreased endogenous thiosulfaturia: a cause of recurrent calcium nephrolithiasis.
abstract: In two earlier publications we reported excellent therapeutic results in patients with recurrent calcium nephrolithiasis, using oral or intravenous i.v. sodium thiosulfate on the one hand, and on treatment of tumorus-soft periarticular tissues calcifications on the other. Thus, we considered useful to measure endogenous thiosulfaturia, using a specific HPLC method, in 25 healthy adult males and 25 patients with recurrent calcium nephrolithiasis. Healthy adult males excreted between 11 and 16 microM/24 hour of endogenous thiosulfate, while patients with recurrent calcium nephrolithiasis excreted significantly lower amounts of 6 and 10 microM/24 hour, except one patient, who did not excrete endogenous thiosulfate, reflecting probably a genetic abnormality. Thiosulfate is a unique agent for treatment of recurrent calcium nephrolithiasis as well as some other abnormal calcium depositions. Two doses of 5 mM sodium thiosulfate daily are therapeutically sufficient.
authors.affiliation: University of Athens, School of Medicine, Laboratory for Experimental Surgery and Surgical Research, Greece. iyatzidi@med.uoa.gr
authors.forename: Hippocrates
authors.initials: H
authors.lastname: Yatzidis
mesh_terms: D000328:Adult; D002118:Calcium / Q000032:analysis; D006801:Humans; D007669:Kidney Calculi / Q000737:chemistry / Q000209:etiology* / Q000652:urine*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D013885:Thiosulfates / Q000652:urine*
chemical_list: D013885:Thiosulfates; D002118:Calcium