[Mechanisms of increased survival rate by administration of AG490 in rats following extensive liver resection].
OBJECTIVE
To study the mechanism by which AG490 improves the survival rate of rats following extensive liver resection.


METHODS
Thirty-eight rats were randomly divided into two groups after surgery: control group (n=10), without treatment; (2) AG490 group (n=28), with AG490 (1 mg x kg(-1) x 12 h(-1)) administrated intraperitoneally immediately and 36 hours after the operation. The survival rate was observed and the serum liver functions were measured.


RESULTS
The survival rates of control group and AG490 group were 0% and 25%. AG490 group had significantly better blood glucose and aminotransferase levels (P < 0.05) than control group; serum bilirubin levels significantly decreased 48 hours after the operation. Serum protein levels in both two groups had slow decrease but without statistical significance (P > 0.05).


CONCLUSIONS
AG490 can significantly increase the survival rate of rats following extensive liver resection. Such a benefit mainly results from the protection towards residual liver function rather than from the promotion of liver regeneration.
Mao
Yi-lei
YL
Liver Surgery Center, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. maoy@public3.bta.net.cn
Yu
Zhuo
Z
Lu
Xin
X
Sang
Xin-ting
XT
Yang
Zhi-ying
ZY
Zhong
Shou-xian
SX
D000410:Alanine Transaminase / Q000097:blood*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood*; D001663:Bilirubin / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006498:Hepatectomy / Q000379:methods; D008297:Male; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D015996:Survival Rate; D020032:Tyrphostins / Q000494:pharmacology*
D001786:Blood Glucose; D004791:Enzyme Inhibitors; D020032:Tyrphostins; C095512:alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D011505:Protein-Tyrosine Kinases; D001663:Bilirubin