Functional heme oxygenase-1 promoter polymorphism in relation to heart failure and cardiac transplantation.
We investigated the functional promoter repeat polymorphism (GT)(n) in the oxidative stress-induced enzyme heme oxygenase-1 in relation to heart failure and complications after transplantation. No influence of the polymorphism on the development of heart failure, graft survival, acute rejection, or transplant atherosclerosis was found.
Holweg
Cecile T J
CT
Department of Internal Medicine, University Medical Center Rotterdam, Rotterdam, The Netherlands. cholweg@cvmed.stanford.edu
Balk
Aggie H M M
AH
Uitterlinden
André G
AG
Niesters
Hubert G M
HG
Maat
Lex P W M
LP
Weimar
Willem
W
Baan
Carla C
CC
D000328:Adult; D001706:Biopsy; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis / Q000235:genetics; D003331:Coronary Vessels / Q000473:pathology; D004247:DNA / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006084:Graft Rejection / Q000235:genetics; D006085:Graft Survival / Q000235:genetics; D006333:Heart Failure / Q000097:blood* / Q000601:surgery; D016027:Heart Transplantation / Q000009:adverse effects; D006419:Heme Oxygenase (Decyclizing) / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D016133:Polymerase Chain Reaction; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012189:Retrospective Studies; D012307:Risk Factors; D014019:Tissue Donors
D004247:DNA; D006419:Heme Oxygenase (Decyclizing)