title: Adolescent alcohol drinking and its long-range consequences. Studies with animal models.
abstract: This chapter reviews findings, mainly obtained from the selectively bred alcohol-preferring (P) line of rats, on (a) the development of alcohol drinking during the peri-adolescent period, (b) neurobiological factors that may contribute to adolescent drinking, (c) interventions to prevent alcohol drinking during adolescence, and (d) some long-lasting consequences of adolescent alcohol drinking. The findings indicate that P rats readily initiate alcohol drinking during the early post-weaning, adolescent and peri-adolescent periods of development. The early age-of-onset of alcohol drinking in the P compared to the NP line is associated with (a) higher densities of serotonin-1A (5-HT1A) receptors in cerebral cortical and hippocampal regions; (b) lower densities of dopamine (DA) D2 receptors in the ventral tegmental area (VTA); (c) higher functional activity in several limbic, cortical and hippocampal regions; and (d) sensitivity to the low-dose stimulating effect of ethanol. Conditioned taste aversion (CTA) training during adolescence produces long-term effects on preventing high alcohol drinking behavior of P rats. Alcohol drinking during peri-adolescence by P rats produces long-lasting effects that increase the acquisition of ethanol self-administration in adulthood, and, in addition, increase craving-like behavior and the potential for alcohol relapse. With suitable animal models, a better understanding of the mechanisms underlying adolescent alcohol drinking and its long-range consequences can be attained.
authors.affiliation: Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, Indiana 46202-4887, USA.
authors.forename: William J
authors.initials: WJ
authors.lastname: McBride
authors.forename: Richard L
authors.initials: RL
authors.lastname: Bell
authors.forename: Zachary A
authors.initials: ZA
authors.lastname: Rodd
authors.forename: Wendy N
authors.initials: WN
authors.lastname: Strother
authors.forename: James M
authors.initials: JM
authors.lastname: Murphy
mesh_terms: D000293:Adolescent; D000428:Alcohol Drinking / Q000453:epidemiology*; D000818:Animals; D001522:Behavior, Animal; D002755:Choice Behavior; D004195:Disease Models, Animal; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D051381:Rats; D012646:Self Administration; D012701:Serotonin / Q000378:metabolism*
chemical_list: D012701:Serotonin; D000431:Ethanol