title: Effect of lower body negative pressure and gravity on regional lung ventilation determined by EIT.
abstract: The aim of our study was to check the effect of varying blood volume in the chest and gravity on the distribution of ventilation and aeration in the lungs. The change in intrathoracic blood volume was elicited by application of lower body negative pressure (LBNP) of -50 cmH2O. The variation of gravity in terms of hypogravity (approximately 0g) and hypergravity (approximately 2g) was induced by changes in vertical acceleration achieved during parabolic flights. Local ventilation magnitude and end-expiratory lung volume were determined in eight human subjects in the ventral and dorsal lung regions within a transverse cross-section of the lower chest by electrical impedance tomography. The subjects were studied in a 20 degrees head-down tilted supine body position during tidal breathing and full forced expirations. During tidal breathing, a significant effect of gravity on local magnitude of ventilation and end-expiratory lung volume was detected in the dorsal lung regions both with and without LBNP. In the ventral regions, this gravity dependency was only observed during LBNP. During forced expiration, LBNP had almost no effect on local ventilation and end-expiratory lung volume in either lung region. Gravity significantly influenced the end-expiratory lung volumes in dorsal lung regions. The results indicate that exposure to LBNP exerts a less appreciable effect on regional lung ventilation than the acute changes in gravity.
authors.affiliation: Department of Anaesthesiological Research, Centre of Anaesthesiology, Emergency and Intensive Care Medicine, University of Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, Germany. isipink@gwdg.de
authors.forename: Inéz
authors.initials: I
authors.lastname: Frerichs
authors.forename: Marc
authors.initials: M
authors.lastname: Bodenstein
authors.forename: Taras
authors.initials: T
authors.lastname: Dudykevych
authors.forename: José
authors.initials: J
authors.lastname: Hinz
authors.forename: Günter
authors.initials: G
authors.lastname: Hahn
authors.forename: Gerhard
authors.initials: G
authors.lastname: Hellige
mesh_terms: D000328:Adult; D001810:Blood Volume / Q000502:physiology*; D002307:Cardiography, Impedance / Q000379:methods*; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D018470:Gravity, Altered; D006801:Humans; D008150:Lower Body Negative Pressure / Q000379:methods*; D008168:Lung / Q000502:physiology*; D008297:Male; D012123:Pulmonary Ventilation / Q000502:physiology*