A case of gastric hyperplastic polyp with malignant transformation.
In this paper we report a case of hyperplastic polyp with malignant transformation. The patient was followed up by annual radiographic and endoscopic examination during 9 years. The first gastroscopy revealed a semi-pedunculated polyp beneath the esophageal-cardiac junction, 1.5cm in diameter and slightly reddish with smooth surface. Histological findings showed a hyperplastic polyp. There was slight change in size, but no change in histological examination of the lesion during the follow-up. In 1996, the biopsy specimen showed an atypical epithelium and the polyp was removed by snear polypectomy. A microscopic examination revealed a well-differentiated adenocarcinoma. Immunohistochemically, p53 and Ki-67 immunostaining showed positive in the carcinoma portion of the adenocarcinoma bearing a hyperplastic polyp in the stomach.
Shibahara
Kotaro
K
Department of Medical Biochemistry Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. sibahara-koutarou@kouseikan.saga.sag.jp
Haraguchi
Yukiaki
Y
Sasaki
Isamu
I
Kiyonari
Hideyasu
H
Oishi
Tatuhiro
T
Iwashita
Akinori
A
Maehara
Yoshihiko
Y
Sugimachi
Keizo
K
D000368:Aged; D002471:Cell Transformation, Neoplastic; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D011127:Polyps / Q000473:pathology*; D013270:Stomach / Q000473:pathology*; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53