title: The LundADose method for planar image activity quantification and absorbed-dose assessment in radionuclide therapy.
abstract: A new method for absorbed-dose assessment in radionuclide therapy is presented in this paper. The method is based on activity quantification by the conjugate-view methodology, applied to serial whole-body, anterior-posterior, scintillation-camera scans. The quantification method is an extension of previous studies, and includes separate corrections for attenuation, scatter, and overlapping organs. Further development has now been undertaken to take into account the capabilities of new dual-head camera systems with a built-in X-ray tube for anatomical imaging. Furthermore, the modeling of time-activity data is included, and dosimetric calculations based on the formalism by the Medical Internal Radiation Dose (MIRD) committee. To streamline absorbed-dose assessments for a large number of patient studies, the programs for quantification, image registration, and absorbed-dose calculations have been embedded in an envelop program termed LundADose, where calculations, to a great extent, are performed automatically. Evaluation of the whole-body activity quantification is performed for patients undergoing radioimmunotherapy by monoclonal antibodies labeled with (111)In or (90)Y.
authors.affiliation: Department of Medical Radiation Physics, Lund University, Lund, Sweden. katarina.sjogreen@radfys.lu.se
authors.forename: Katarina
authors.initials: K
authors.lastname: Sjögreen
authors.forename: Michael
authors.initials: M
authors.lastname: Ljungberg
authors.forename: Karin
authors.initials: K
authors.lastname: Wingårdh
authors.forename: David
authors.initials: D
authors.lastname: Minarik
authors.forename: Sven-Erik
authors.initials: SE
authors.lastname: Strand
mesh_terms: D003037:Cobalt Radioisotopes; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D007205:Indium Radioisotopes / Q000627:therapeutic use*; D019047:Phantoms, Imaging; D011874:Radiometry / Q000379:methods; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D014057:Tomography, X-Ray Computed; D014915:Whole-Body Counting / Q000379:methods; D014965:X-Rays; D015021:Yttrium Radioisotopes / Q000627:therapeutic use*
chemical_list: D003037:Cobalt Radioisotopes; D007205:Indium Radioisotopes; D015021:Yttrium Radioisotopes