Likelihood-enhanced fast translation functions.
This paper is a companion to a recent paper on fast rotation functions [Storoni et al. (2004), Acta Cryst. D60, 432-438], which showed how a Taylor-series expansion of the maximum-likelihood rotation function leads to improved likelihood-enhanced fast rotation functions. In a similar manner, it is shown here how linear and quadratic Taylor-series expansions and least-squares approximations of the maximum-likelihood translation function lead to likelihood-enhanced translation functions, which can be calculated by FFT and which are more sensitive to the correct translation than the traditional correlation-coefficient fast translation function. These likelihood-enhanced translation targets for molecular-replacement searches have been implemented in the program Phaser using the Computational Crystallography Toolbox (cctbx).
McCoy
Airlie J
AJ
Department of Haematology, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 2XY, England.
Grosse-Kunstleve
Ralf W
RW
Storoni
Laurent C
LC
Read
Randy J
RJ
D001426:Bacterial Proteins / Q000737:chemistry; D003461:Crystallography / Q000379:methods*; D004546:Elapid Venoms / Q000737:chemistry; D016018:Least-Squares Analysis; D016013:Likelihood Functions; D012984:Software; D001618:beta-Lactamases / Q000737:chemistry
D001426:Bacterial Proteins; D004546:Elapid Venoms; C065596:beta-lactamase-inhibitor protein, Streptomyces; C020273:dendrotoxin; D001618:beta-Lactamases