Nogo expression in muscle correlates with amyotrophic lateral sclerosis severity.
Nogo, a protein inhibiting axonal regeneration, exhibits a characteristic isoform-specific pattern of expression in skeletal muscle of transgenic mice and patients with amyotrophic lateral sclerosis. Here, the increased levels of Nogo-A or Nogo-B in muscle biopsies of 15 amyotrophic lateral sclerosis patients significantly correlated with the severity of clinical disability and with the degree of muscle fiber atrophy. Nogo-A immunoreactivity was observed selectively in atrophic slow-twitch type I fibers. These results suggest that Nogo expression in muscle is a marker of amyotrophic lateral sclerosis severity.
Jokic
Natasa
N
Laboratoire de Signalisations Moléculaires et Neurodégénérescence, Université Louis Pasteur, Strasbourg, France.
Gonzalez de Aguilar
Jose-Luis
JL
Pradat
Pierre-François
PF
Dupuis
Luc
L
Echaniz-Laguna
Andoni
A
Muller
André
A
Dubourg
Odile
O
Seilhean
Danielle
D
Hauw
Jean-Jacques
JJ
Loeffler
Jean-Philippe
JP
Meininger
Vincent
V
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism*; D015415:Biomarkers / Q000032:analysis*; D015153:Blotting, Western; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018657:Muscle Fibers, Slow-Twitch / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism*; D009185:Myelin Proteins / Q000096:biosynthesis*; D000070798:Nogo Proteins; D012720:Severity of Illness Index
D015415:Biomarkers; D009185:Myelin Proteins; D000070798:Nogo Proteins; C000603199:RTN4 protein, human; C000603201:Rtn4 protein, mouse