Uterine epithelioid endometrial stromal sarcoma presenting as a "cervical polyp".
Although appearance of conventional uterine endometrial stromal sarcoma is easily recognized on histology, it may uncommonly assume unusual appearances such as uterine tumor resembling ovarian sex-cord tumor, thereby hindering its diagnosis. Recently, its manifestation as an epithelioid neoplasm was described. In this report, we detail yet another instance where this tumor adopted an epithelioid morphology, presenting itself as a polyp extruding from the cervical os in a 41-year-old Chinese woman. Both the polypectomy and subsequent hysterectomy specimens revealed a predominant proliferation of CD10-negative, caldesmon-negative, and CD117-positive epithelioid cells set within a stroma containing vascular proliferation resembling endometrial stromal tumor. Areas of typical low-grade endometrial stromal sarcoma containing spindle cells that were focally positive for CD10 and negative for CD117 were present in close association with the epithelioid areas. The differential diagnoses and possible implication of CD117 positivity are discussed.
Goh
Seng Geok Nicholas
SG
Department of Pathology, Singapore General Hospital, Singapore. gnick@pacific.net.sg
Chuah
Khoon Leong
KL
Chew
Sung Hock
SH
Tan
Puay Hoon
PH
D000328:Adult; D003937:Diagnosis, Differential; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D015260:Neprilysin / Q000378:metabolism; D011127:Polyps / Q000175:diagnosis*; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism; D018203:Sarcoma, Endometrial Stromal / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis*
D019009:Proto-Oncogene Proteins c-kit; D015260:Neprilysin