Cuminaldehyde: Aldose Reductase and alpha-Glucosidase Inhibitor Derived from Cuminum cyminum L. Seeds.
The inhibitory activity of Cuminum cyminum seed-isolated component was evaluated against lens aldose reductase and alpha-glucosidase isolated from Sprague-Dawley male rats and compared to that of 11 commercially available components derived from C. cyminum seed oil, as well as quercitrin as an aldose reductase inhibitor and acarbose as an alpha-glucosidase inhibitor. The biologically active constituent of C. cyminum seed oil was characterized as cuminaldehyde by various spectral analyses. The IC(50) value of cuminaldehyde is 0.00085 mg/mL against aldose reductase and 0.5 mg/mL against alpha-glucosidase, respectively. Cuminaldehyde was about 1.8 and 1.6 times less in inhibitory activity than acarbose and quercitin, respectively. Nonetheless, cuminaldehyde may be useful as a lead compound and a new agent for antidiabetic therapeutics.
Lee
Hoi-Seon
HS
Faculty of Biotechnology and Research Center for Industrial Development of Biofood Materials, College of Agriculture & Life Science, Chonbuk National University, Chonju 561-756, Korea. hoiseon@chonbuk.ac.uk
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D001547:Benzaldehydes / Q000302:isolation & purification / Q000494:pharmacology*; D028527:Cuminum / Q000737:chemistry*; D000081007:Cymenes; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D008401:Gas Chromatography-Mass Spectrometry; D065089:Glycoside Hydrolase Inhibitors; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
D001547:Benzaldehydes; D000081007:Cymenes; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D000449:Aldehyde Reductase; C007165:cuminaldehyde