title: Patent foramen ovale morphology and impact on percutaneous device closure.
abstract: We sought to evaluate the effects of atrial septal and patent foramen ovale (PFO) morphology on the efficacy of transcatheter closure. We performed a retrospective analysis of all patients who underwent PFO device closure from January 1997 to January 2002. Forty-seven patients underwent percutaneous closure of a PFO with a median age of 45 years (range, 8-75) and weight of 76 kg (range 28-115). The septal morphology was flat in 33 and aneurysmal in 14 patients. The PFO morphology was a simple flap in 20 and complex in 27 patients. Complex morphologies included long-tunnel PFO (n = 15), coexistent small atrial septal defect (ASD) (n = 5), and aneurysmal septum without a tunnel or ASD (n = 7). Nonstretched PFO diameters were significantly smaller than stretched (4.8 +/- 1.1 mm vs 11.6 +/- 3.8 mm, p < 0.01). Median device size: stretched diameter ratio (DS:SD) was 3.7:1 (range, 2.2-9.1). The DS:SD ratio was significantly higher in patients with complex PFO (mean, 3.9:1 vs 2.6:1; p < 0.05). Device placement was successful in all patients. Five patients required transeptal puncture of the foraminal flap in long-tunnel PFOs. Effective closure on follow-up was achieved in 45 patients (95%). Of the 2 patients with residual shunts, 1 had a complex PFO and the other a simple PFO. Two patients (5%) experienced recurrent neurologic symptoms after device closure despite having no residual shunt by echocardiography. Complex PFO did not increase risk of residual shunt or recurrent neurologic symptoms after device closure.
authors.affiliation: Department of Pediatric Cardiology, Rumailah Hospital, Qatar. howaidaelsaid@texaschildrenshospital.org
authors.forename: H G
authors.initials: HG
authors.lastname: El Said
authors.forename: C J
authors.initials: CJ
authors.lastname: McMahon
authors.forename: C E
authors.initials: CE
authors.lastname: Mullins
authors.forename: R H
authors.initials: RH
authors.lastname: Pignatelli
authors.forename: R G
authors.initials: RG
authors.lastname: Grifka
authors.forename: M R
authors.initials: MR
authors.lastname: Nihill
authors.forename: J A
authors.initials: JA
authors.lastname: Vincent
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019736:Prostheses and Implants; D012189:Retrospective Studies; D016896:Treatment Outcome