A case of Takayasu arteritis complicated with glomerulonephropathy mimicking membranoproliferative glomerulonephritis.
We report on a 65-year-old Japanese woman with Takayasu arteritis who developed severe proteinuria, hypertension, and renal dysfunction. Renal angiography demonstrated moderate irregular narrowing of both renal arteries. Renal biopsy showed glomerulonephropathy mimicking membranoproliferative glomerulonephritis (MPGN) with glomerular capillary wall thickening ("double contour") accompanied by mesangial cell proliferation and moderate increase of mesangial matrix without deposits of C3. Electron microscopy showed no subendothelial deposit and no circumferential mesangial interposition (CMI), and these findings are different from MPGN. In this report we present a case of Takayasu arteritis associated with glomerulonephropathy mimicking MPGN.
Kuroda
Takeshi
T
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-Dori, 951-8510 Niigata City, Japan. kurodat@med.niigata-u.ac.jp
Ohbayashi
Hiroaki
H
Murakami
Syuuichi
S
Ito
Satoshi
S
Sakatsume
Minoru
M
Ueno
Mitsuhiro
M
Nishi
Shinichi
S
Nakano
Masaaki
M
Gejyo
Fumitake
F
D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D005921:Glomerulonephritis / Q000175:diagnosis* / Q000209:etiology; D015432:Glomerulonephritis, Membranoproliferative / Q000175:diagnosis; D006801:Humans; D013625:Takayasu Arteritis / Q000150:complications*