In vitro alpha-glucosidase inhibitory effect of Zn(II) complex with 6-methyl-2-picolinmethylamide.
We found alpha-glucosidase inhibitory effect of Zn(II) complex with 6-methyl-2-picolinmethylamide (6mpa-ma) which showed the highest blood glucose lowering effect in Zn(II) complexes with picolinamide derivatives in KK-A(y) mice. The Zn(II) complex showed strong alpha-glucosidase inhibitory activity greater by about eighty times (substrate: maltose) and forty times (substrate: sucrose) compared with acarbose.
Ueda
Eriko
E
Graduate School of Life Science, Kobe Women's University, Kobe, Japan.
Yoshikawa
Yutaka
Y
Sakurai
Hiromu
H
Kojima
Yoshitane
Y
Kajiwara
Naemi M
NM
D000818:Animals; D002712:Chlorides; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D051379:Mice; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D017967:Zinc Compounds
D002712:Chlorides; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D009942:Organometallic Compounds; D011725:Pyridines; D017967:Zinc Compounds; C502179:Zn(II) 6-methyl-2-picolinmethylamide; C016837:zinc chloride