title: Biological behavior of hat-stacked carbon nanofibers in the subcutaneous tissue in rats.
abstract: The tissue response to hat-stacked carbon nanofibers (H-CNFs) was evaluated. H-CNFs were implanted in the subcutaneous tissue of rats. Histological and ultrastructural investigations were carried out by transmission electron microscopy. Although many macrophages and foreign body giant cells were seen around H-CNFs, no severe inflammatory response such as necrosis was observed. Some H-CNFs were observed in lysosomal vacuoles of phagocytes. These results showed that H-CNFs were not strong prophlogistic substances and were englobed in vivo.
authors.affiliation: Graduate School of Dental Medicine, Hokkaido University, Japan. yokoyama@den.hokudai.ac.jp
authors.forename: Atsuro
authors.initials: A
authors.lastname: Yokoyama
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Sato
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Nodasaka
authors.forename: Satoru
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Takao
authors.initials: T
authors.lastname: Kawasaki
authors.forename: Masanobu
authors.initials: M
authors.lastname: Shindoh
authors.forename: Takao
authors.initials: T
authors.lastname: Kohgo
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Akasaka
authors.forename: Motohiro
authors.initials: M
authors.lastname: Uo
authors.forename: Fumio
authors.initials: F
authors.lastname: Watari
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Tohji
mesh_terms: D000818:Animals; D002244:Carbon / Q000737:chemistry* / Q000633:toxicity; D008297:Male; D008422:Materials Testing; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry* / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D040521:Subcutaneous Tissue / Q000648:ultrastructure*
chemical_list: D002244:Carbon