Anthecotulide: purification, analytical data, absence from chamomile preparations, stability and reactivity, and anti-infective testing.
The sesquiterpene lactone anthecotulide (1) was extracted from Anthemis cotula in 0.7% w/w yield. A pure standard was prepared by preparative TLC and used for quantitative determination of 1 with a TLC scanner. The constitution of 1 was corroborated and the double-bond configuration determined. It was stable at room temparature in air and reacted very slowly with glutathione. It was not detectable in 34 chamomile (Matricaria recutita) preparations and did not show antibacterial activity against a range of clinically important strains at a concentration of <10 microg/mL.
Meyer
Achim
A
Institut für Pharmazeutische Chemie der Martin-Luther-Universität Halle, Wolfgang-Langenbeck-Strasse 4, D-06120 Halle, Germany.
Zimmermann
Stefan
S
Hempel
Bernd
B
Imming
Peter
P
D031166:Anthemis / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020843:Chamomile; D002855:Chromatography, Thin Layer; D005858:Germany; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000890:Anti-Infective Agents; D007783:Lactones; D012717:Sesquiterpenes; C499300:anthecotulide