[Peculiarities of the temporal organization of the behavioral response to caffeine in rats].
Chronic administration of a standard dose of caffeine (40 mg/kg) facilitated the formation of more clear circadian mobility rhythm in rats. The test animals belonging to various chronotypes exhibited a significant difference in sensitivity with respect to this psychostimulant. Rats possessing a more pronounced rhythm organization showed a greater increase in the rhythm amplitude, with the acrophase more significantly shifted toward early night hours. It is suggested that the individual chronotype features have to be taken into account in experimental and clinical pharmacology.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002110:Caffeine / Q000008:administration & dosage*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage*; D002940:Circadian Rhythm / Q000187:drug effects*; D008297:Male; D051381:Rats
D000697:Central Nervous System Stimulants; D002110:Caffeine