title: Binding of isotryptamines and indenes at h5-HT6 serotonin receptors.
abstract: To determine if the indolic nitrogen atom is required for the binding of N(1)-benzyltryptamines at h5-HT(6) serotonin receptors, several isotryptamines and indene analogs were examined. The affinity of 3-benzyl-N(1)-(N,N-dimethylaminoethyl)indole (5, K(i)=32nM) and 1-benzyl-3-(N,N-dimethylaminoethyl)indene (11, K(i)=3nM) indicates that the indolic nitrogen atom is not essential for binding.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298-0540, USA.
authors.forename: Renata
authors.initials: R
authors.lastname: Kolanos
authors.forename: Uma
authors.initials: U
authors.lastname: Siripurapu
authors.forename: Manik
authors.initials: M
authors.lastname: Pullagurla
authors.forename: Mohamed
authors.initials: M
authors.lastname: Riaz
authors.forename: Vince
authors.initials: V
authors.lastname: Setola
authors.forename: Bryan L
authors.initials: BL
authors.lastname: Roth
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Dukat
authors.forename: Richard A
authors.initials: RA
authors.lastname: Glennon
mesh_terms: D001665:Binding Sites; D006801:Humans; D007192:Indenes / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D011985:Receptors, Serotonin / Q000737:chemistry / Q000378:metabolism*; D014363:Tryptamines / Q000737:chemistry / Q000378:metabolism*
chemical_list: D007192:Indenes; D011985:Receptors, Serotonin; D014363:Tryptamines; C097216:serotonin 6 receptor