title: Genomic determinants of prognosis in colorectal cancer.
abstract: Colorectal cancer progression is characterized by the sequential acquisition of multiple genetic aberrations. Insights into the biology of cancer cell and the development of novel methodologies have open a new frontier in the search of independent molecular factors to better predict outcome. Besides the generation of a large list of candidate markers, their applicability in routine clinical settings has been hindered by the heterogeneity of the disease. The analysis of cumulated genetic damage offers a more comprehensive measure of the cancer cell's genomic disruption and appears as a gauge of malignant potential. The prognostic application of different determinants of genomic damage is reviewed.
authors.affiliation: IDIBELL-Institut de Recerca Oncològica, Hospital Duran i Reynals, Granvia km 2,7, L'Hospitalet, Barcelona 08907, Spain.
authors.forename: Elisenda
authors.initials: E
authors.lastname: Vendrell
authors.forename: Cristina
authors.initials: C
authors.lastname: Morales
authors.forename: Rosa-Ana
authors.initials: RA
authors.lastname: Risques
authors.forename: Gabriel
authors.initials: G
authors.lastname: Capellà
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Peinado
mesh_terms: D014408:Biomarkers, Tumor; D002869:Chromosome Aberrations; D015179:Colorectal Neoplasms / Q000235:genetics*; D004249:DNA Damage; D018450:Disease Progression; D007621:Karyotyping; D009154:Mutation; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor