title: Effects of protein vs. carbohydrate-rich diets on fuel utilisation in obese women during weight loss.
abstract: BACKGROUND
  Energy restriction is a common therapeutic approach for weight reduction, but the most effective macronutrient distribution of the hypoenergetic diet as well as the role of the metabolic processes involved require further investigations.
  
  
  OBJECTIVE
  To study the effect of a high protein (HP) hypoenergetic diet compared with a high carbohydrate (HC) hypoenergetic diet on fuel utilisation changes during the weight loss process in obese women.
  
  
  METHODS
  Eleven obese (BMI>30) women were randomly assigned to a 10w dietary intervention study comparing HP (30% protein) or HC (55% carbohydrate) energy restricted diets providing 30% energy fat content. Substrate utilisation was evaluated by indirect calorimetry. Body weight and composition (Bod Pod) and blood measurements were performed before and after weight loss.
  
  
  RESULTS
  On average, the individuals on the HP dietary group lost 4.4 kg more than those in the HC program (p<0.50), which was mainly due to a fat mass loss (3.7 kg, p<0.05) with no statistical differences in lean body mass reduction. These losses were accompanied by a significant decrease in fasting leptin in the HP group (-52%; P<0.05). On the other hand post-absorptive lipid oxidation decreased in the HC group (-48%) and remained unchanged in the HP groups.
  
  
  CONCLUSIONS
  The replacement of some dietary carbohydrate by protein in energy restricted diets, improves weight and fat losses and specifically promotes lipid oxidation in the fasting state, without major different in lean body mass depletion.
authors.affiliation: Department of Physiology and Nutrition, University Clinic University of Navarra, Pamplona, Spain.
authors.forename: Idoia
authors.initials: I
authors.lastname: Labayen
authors.forename: Nieves
authors.initials: N
authors.lastname: Díez
authors.forename: Alvaro
authors.initials: A
authors.lastname: González
authors.forename: Dolores
authors.initials: D
authors.lastname: Parra
authors.forename: J Alfredo
authors.initials: JA
authors.lastname: Martínez
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D001823:Body Composition / Q000187:drug effects / Q000502:physiology; D004038:Diet, Reducing; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004044:Dietary Proteins / Q000008:administration & dosage*; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000178:diet therapy*; D016896:Treatment Outcome; D015431:Weight Loss / Q000187:drug effects* / Q000502:physiology
chemical_list: D004040:Dietary Carbohydrates; D004044:Dietary Proteins; D020738:Leptin