Transmission of caprine herpesvirus 2 in domestic goats.
Caprine herpesvirus 2 (CpHV-2) is a recently recognized gammaherpesvirus that is endemic in domestic goats and has been observed to cause clinical malignant catarrhal fever (MCF) in certain species of deer. In this study, transmission of CpHV-2 in goats was examined. A total of 30 kids born to a CpHV-2 positive goat herd were selected and divided into two groups: group 1 (n=16) remained in the positive herd; group 2 (n=14) was separated from the herd at 1 week of age after obtaining colostrum. Peripheral blood samples from each kid were examined regularly by competitive ELISA for MCF viral antibody and by PCR for CpHV-2 DNA. Fifteen out of 16 goats (94%) that remained with the positive herd seroconverted and became PCR-positive for CpHV-2 by 10 months of age. In contrast, all kids (100%) that were separated from the positive herd at 1 week of age remained negative until termination of the experiment at 1 year of age. Additional transmission experiments revealed that all CpHV-2-free adult goats were susceptible to CpHV-2 or ovine herpesvirus 2 (OvHV-2) infection. The data indicate that the transmission pattern of CpHV-2 in goats is similar to the pattern of OvHV-2 in sheep and that CpHV-2-free goats can be established by early separation of kids from positive herds, which has significant implications for MCF control programs.
Li
Hong
H
Animal Diseases Research Unit, USDA-Agriculture Research Service, 3003 ADBF, Washington State University, Pullman, WA 99164-6630, USA. hli@vetmed.wsu.edu
Keller
Janice
J
Knowles
Donald P
DP
Taus
Naomi S
NS
Oaks
J Lindsay
JL
Crawford
Timothy B
TB
D000822:Animal Husbandry / Q000379:methods*; D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000097:blood; D004279:DNA, Viral / Q000032:analysis; D019353:Endemic Diseases / Q000517:prevention & control / Q000662:veterinary; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D018142:Gammaherpesvirinae / Q000276:immunology / Q000502:physiology*; D015511:Goat Diseases / Q000517:prevention & control / Q000635:transmission* / Q000821:virology; D006041:Goats; D006566:Herpesviridae Infections / Q000517:prevention & control / Q000635:transmission / Q000662:veterinary*; D016133:Polymerase Chain Reaction / Q000662:veterinary; D011897:Random Allocation; D012756:Sheep; D012757:Sheep Diseases / Q000635:transmission* / Q000821:virology
D000914:Antibodies, Viral; D004279:DNA, Viral