title: The effect of nitroglycerin on microvascular perfusion and oxygenation during gastric tube reconstruction.
abstract: Esophagectomy followed by gastric tube reconstruction is the surgical treatment of choice for patients with esophageal cancer. Complications of the cervical anastomosis are associated with impaired microvascular blood flow (MBF) and ischemia in the gastric fundus. The aim of the present study was to differentiate whether the decrease in MBF is a result of arterial insufficiency or of venous congestion. To do this we assessed MBF, microvascular hemoglobin oxygen saturation (muHbSo(2)), and microvascular hemoglobin concentration (muHbcon) simultaneously during different stages of gastric tube reconstruction. In 14 patients, MBF was determined with laser Doppler flowmetry, and muHbSo(2) and muHbcon were determined with reflectance spectro- photometry. After completion of the anastomosis, nitroglycerin was applied at the fundus. Although MBF did not change significantly in the pylorus, MBF decreased progressively during surgery in the fundus from 210 +/- 18 Arbitrary Units at baseline (normal stomach) to 52 +/- 9 Arbitrary Units after completion of reconstruction (mean +/- sem; P < 0.05). There was no change in muHbSo(2) and muHbcon during the reconstruction. After application of nitroglycerin, MBF doubled. We conclude that MBF decreases during gastric tube reconstruction but that muHbSo(2) and muHbcon do not. This decrease might be the result of venous congestion, which can partly be counteracted by application of nitroglycerin.
authors.affiliation: Departments of *Anesthesiology and †Surgery, Erasmus Medical Center, Rotterdam, and ‡Department of Physiology, Amsterdam Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Marc P
authors.initials: MP
authors.lastname: Buise
authors.forename: Can
authors.initials: C
authors.lastname: Ince
authors.forename: Hugo W
authors.initials: HW
authors.lastname: Tilanus
authors.forename: Jan
authors.initials: J
authors.lastname: Klein
authors.forename: Diederik
authors.initials: D
authors.lastname: Gommers
authors.forename: Jasper
authors.initials: J
authors.lastname: van Bommel
mesh_terms: D000328:Adult; D000368:Aged; D001158:Arteries / Q000601:surgery; D001784:Blood Gas Analysis; D004938:Esophageal Neoplasms / Q000601:surgery; D016629:Esophagectomy; D004947:Esophagus / Q000601:surgery*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008026:Ligation; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D008875:Middle Aged; D005996:Nitroglycerin / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood*; D019651:Plastic Surgery Procedures; D012039:Regional Blood Flow / Q000187:drug effects; D013270:Stomach / Q000098:blood supply* / Q000187:drug effects / Q000601:surgery; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D006454:Hemoglobins; D014665:Vasodilator Agents; D005996:Nitroglycerin; D010100:Oxygen