title: Hippocampal and ventricular volumes in psychotic and nonpsychotic bipolar patients compared with schizophrenia patients and community control subjects: a pilot study.
abstract: BACKGROUND
  Previous reports of ventricular and hippocampal volumes in patients with bipolar disorder (BP) have been inconsistent in their findings. One possibility is that volumetric abnormalities are determined by disease subtype. Prior evidence suggests that psychotic (PBP) and nonpsychotic (NPBP) forms of BP are two subtypes that might differ in pathophysiology.
  
  
  METHODS
  We investigated ventricular and hippocampal volumes in 38 adults with clearly defined PBP (n = 23) and NPBP subtypes, compared with 33 persons with schizophrenia (SZ) and 44 healthy community control subjects (HC). Ventricular and hippocampal volumes were reliably measured on high-resolution anatomic magnetic resonance imaging scans. We used a multivariate analysis of covariance to compare volumes across groups, covarying for total brain volume. Potential effects of BP illness features were explored, contrasting PBP and NPBP.
  
  
  RESULTS
  For ventricular but not hippocampal regions, we found significant volume difference in PBP but not NPBP compared with HC (p < .005). We also observed nonsignificantly smaller left hippocampal volumes in PBP versus HC. Schizophrenic subjects had significantly larger ventricular and smaller left hippocampal volumes than HC.
  
  
  CONCLUSIONS
  These results suggest that PBP but not NPBP is associated with increased ventricle volumes and a trend toward smaller left hippocampal volumes, as observed in SZ.
authors.affiliation: Division of Psychiatric Neuroimaging, Johns Hopkins University, Baltimore, Catonsville, Maryland.
authors.forename: Heather C
authors.initials: HC
authors.lastname: Strasser
authors.forename: Jessica
authors.initials: J
authors.lastname: Lilyestrom
authors.forename: Ebony R
authors.initials: ER
authors.lastname: Ashby
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Honeycutt
authors.forename: David J
authors.initials: DJ
authors.lastname: Schretlen
authors.forename: Ann E
authors.initials: AE
authors.lastname: Pulver
authors.forename: Ramona O
authors.initials: RO
authors.lastname: Hopkins
authors.forename: J Raymond
authors.initials: JR
authors.lastname: Depaulo
authors.forename: James B
authors.initials: JB
authors.lastname: Potash
authors.forename: Barbara
authors.initials: B
authors.lastname: Schweizer
authors.forename: Khara O
authors.initials: KO
authors.lastname: Yates
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Kurian
authors.forename: Patrick E
authors.initials: PE
authors.lastname: Barta
authors.forename: Godfrey D
authors.initials: GD
authors.lastname: Pearlson
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000150:complications / Q000473:pathology*; D002552:Cerebral Ventricles / Q000473:pathology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009483:Neuropsychological Tests; D010865:Pilot Projects; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000150:complications / Q000473:pathology*; D012111:Residence Characteristics; D012559:Schizophrenia / Q000150:complications / Q000473:pathology*