Dental gel viscosity parameters and pharmaceutical availability of non-steroidal anti-inflammatory drugs.
Model prescription for dental anti-inflammatory gels with carboxymethylcellulose sodium salt and non-ionic surfactants have been worked out. Viscosity parameters of 10 variant gel forms were investigated and an attempt on their interpretation was undertaken in relation to pharmaceutical availability of non-steroidal anti-inflammatory drugs (diclofenac, ibuprofen sodium). Viscosity tests demonstrated higher pharmaceutical availability of ibuprofen sodium than of diclofenac sodium particularly from model gels with surfactants of low number of oxyethylene segments in the structure. The above has been confirmed by in vitro studies on the kinetics of therapeutic agent penetration into external compartment.
Kołodziejska
Justyna
J
Department of Applied Pharmacy, Medical University of Lódź, 90-151 Lódź, Poland.
Zgoda
Marian Mikołaj
MM
D000465:Algorithms; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D001682:Biological Availability; D002266:Carboxymethylcellulose Sodium; D005079:Excipients; D005782:Gels; D014783:Viscosity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005079:Excipients; D005782:Gels; D002266:Carboxymethylcellulose Sodium