title: Interleukin-10 promoter polymorphism is associated with decreased breast cancer risk.
abstract: Interleukin-10 (IL-10) is an immunosuppressive cytokine which may facilitate development of cancer by supporting tumor escape from the immune response. A [TCATA] haplotype formed by polymorphisms at positions -3575, -2763, -1082, -819 and -592 in the promoter of the IL-10 gene is a strong determinant for IL-10 expression. The presence of this haplotype can be determined by analysis of the -592C > A polymorphism. Aim of the present study was to analyze the role of the IL-10 [TCATA] haplotype for breast cancer. We performed a case-control study including 500 female patients with histologically confirmed breast cancer and 500 female, age-matched, healthy control subjects from population-based screening studies. The -592C > A polymorphism was determined by a 5'-nuclease assay (TaqMan). Frequency of the homozygous -592 AA genotype, indicating homozygosity for the [TCATA] haplotype, was 4.2% among patients and 7.3% among controls (p=0.038; odds ratio 0.56; 95% confidence interval 0.32-0.97). IL-10 genotypes were not associated with tumor size, histological grading, estrogen or progesterone receptor status and age at diagnosis. Therefore we conclude that the IL-10 -592C > A promoter polymorphism may be associated with a reduced breast cancer risk.
authors.affiliation: Department of Internal Medicine, Division of Oncology, Medical University Graz, Auenbruggerplatz 15, 8036, Graz, Austria. uwe.langsenlehner@klinikum.graz.at
authors.forename: Uwe
authors.initials: U
authors.lastname: Langsenlehner
authors.forename: Peter
authors.initials: P
authors.lastname: Krippl
authors.forename: Wilfried
authors.initials: W
authors.lastname: Renner
authors.forename: Babak
authors.initials: B
authors.lastname: Yazdani-Biuki
authors.forename: Tanja
authors.initials: T
authors.lastname: Eder
authors.forename: Herwig
authors.initials: H
authors.lastname: Köppel
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Wascher
authors.forename: Bernhard
authors.initials: B
authors.lastname: Paulweber
authors.forename: Hellmut
authors.initials: H
authors.lastname: Samonigg
mesh_terms: D001317:Austria / Q000453:epidemiology; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D016555:Matched-Pair Analysis; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012306:Risk
chemical_list: D016753:Interleukin-10