title: Liver resection: 10-year experience from a single institution.
abstract: BACKGROUND
  Liver resection constitutes the main treatment of most liver primary neoplasms and selected cases of metastatic tumors. However, this procedure is associated with significant morbidity and mortality rates.
  
  
  OBJECTIVE
  To analyze our experience with liver resections over a period of 10 years to determine the morbidity, mortality and risk factors of hepatectomy.
  
  
  METHODS
  Retrospective review of medical records of patients who underwent liver resection from January 1994 to March 2003.
  
  
  RESULTS
  Eighty-three (41 women and 42 men) patients underwent liver resection during the study period, with a mean age of 52.7 years (range 13-82 years). Metastatic colorectal carcinoma and hepatocellular carcinoma were the main indications for hepatic resection, with 36 and 19 patients, respectively. Extended and major resections were performed in 20.4% and 40.9% of the patients, respectively. Blood transfusion was needed in 38.5% of the operations. Overall morbidity was 44.5%. Life-threatening complications occurred in 22.8% of cases and the most common were pneumonia, hepatic failure, intraabdominal collection and intraabdominal bleeding. Among minor complications (30%), the most common were biliary leakage and pleural effusion. Size of the tumor and blood transfusion were associated with major complications (P = 0.0185 and P = 0.0141, respectively). Operative mortality was 8.4% and risk factors related to mortality were increased age and use of vascular exclusion (P = 0.0395 and P = 0.0404, respectively). Median hospital stay was 6.7 days.
  
  
  CONCLUSIONS
  Liver resections can be performed with low mortality and acceptable morbidity rates. Blood transfusion may be reduced by employing meticulous technique and, whenever indicated, vascular exclusion.
authors.affiliation: Digestive Surgery Division, Hospital de Clínicas, Federal University of Parana.
authors.forename: Julio Cezar Uili
authors.initials: JC
authors.lastname: Coelho
authors.forename: Christiano Marlo Paggi
authors.initials: CM
authors.lastname: Claus
authors.forename: Tiago Noguchi
authors.initials: TN
authors.lastname: Machuca
authors.forename: Wagner Herbert
authors.initials: WH
authors.lastname: Sobottka
authors.forename: Carolina Gomes
authors.initials: CG
authors.lastname: Gonçalves
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001803:Blood Transfusion / Q000706:statistics & numerical data; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects / Q000401:mortality*; D006801:Humans; D008107:Liver Diseases / Q000401:mortality / Q000601:surgery*; D008113:Liver Neoplasms / Q000401:mortality / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012189:Retrospective Studies; D012307:Risk Factors