title: From oogenesis through gastrulation: developmental regulation of apoptosis.
abstract: Apoptosis is a mechanism employed by multicellular organisms throughout development as a means of eliminating damaged or otherwise unwanted cells. From oogenesis through fertilization and gastrulation, organisms use an array of cell- and tissue-specific mechanisms to regulate the apoptotic program in response to stress or developmental cues. Since cell death regulation is tightly interwoven with cell cycle and checkpoint controls, and embryos of the fly, fish and frog exhibit unique embryonic cell cycle regulation, it is of great interest to understand how early embryos coordinate these cellular functions.
authors.affiliation: Integrated Program in Cellular, Molecular, and Biophysical Studies, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
authors.forename: Jessica
authors.initials: J
authors.lastname: Greenwood
authors.forename: Jean
authors.initials: J
authors.lastname: Gautier
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D017173:Caenorhabditis elegans / Q000196:embryology*; D002453:Cell Cycle / Q000502:physiology; D004249:DNA Damage / Q000502:physiology; D004330:Drosophila / Q000196:embryology*; D005775:Gastrula / Q000502:physiology*; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D009866:Oogenesis / Q000502:physiology*; D014981:Xenopus; D015027:Zebrafish / Q000196:embryology / Q000502:physiology
chemical_list: D020928:Mitogen-Activated Protein Kinases