title: Synthesis and anticonvulsant activity of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles.
abstract: A series of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles have been synthesized and evaluated as anticonvulsant agents. Compound 4b shows considerable anticonvulsant activity both in PTZ and MES models. It seems this effect is mediated through benzodiazepine receptors mechanism.
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran 141556153, Iran. azarghi@yahoo.com
authors.forename: Afshin
authors.initials: A
authors.lastname: Zarghi
authors.forename: Sayyed A
authors.initials: SA
authors.lastname: Tabatabai
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Faizi
authors.forename: Avideh
authors.initials: A
authors.lastname: Ahadian
authors.forename: Parisa
authors.initials: P
authors.lastname: Navabi
authors.forename: Vahideh
authors.initials: V
authors.lastname: Zanganeh
authors.forename: Abbas
authors.initials: A
authors.lastname: Shafiee
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D001593:Benzyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D004597:Electroshock / Q000379:methods; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D010433:Pentylenetetrazole; D011963:Receptors, GABA-A / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000927:Anticonvulsants; D001593:Benzyl Compounds; D010069:Oxadiazoles; D011963:Receptors, GABA-A; D010433:Pentylenetetrazole