title: Design, synthesis and activity of novel derivatives of oxybutynin and tolterodine.
abstract: Novel derivatives of Tolterodine (1) and Oxybutynin (2) have been designed using conformationally restricted azabicyclics as replacement for open-chain amines. The synthesis and structure-activity relationships are presented.
authors.affiliation: Ranbaxy Research Laboratories, New Drug Discovery Research, Department of Medicinal Chemistry, Gurgaon 122 001, Haryana, India.
authors.forename: Kirandeep
authors.initials: K
authors.lastname: Kaur
authors.forename: Shelly
authors.initials: S
authors.lastname: Aeron
authors.forename: Miriyala
authors.initials: M
authors.lastname: Bruhaspathy
authors.forename: Shankar J
authors.initials: SJ
authors.lastname: Shetty
authors.forename: Suman
authors.initials: S
authors.lastname: Gupta
authors.forename: Laxminarayan H
authors.initials: LH
authors.lastname: Hegde
authors.forename: Arun D V
authors.initials: AD
authors.lastname: Silamkoti
authors.forename: Anita
authors.initials: A
authors.lastname: Mehta
authors.forename: Anita
authors.initials: A
authors.lastname: Chugh
authors.forename: Jang B
authors.initials: JB
authors.lastname: Gupta
authors.forename: P K S
authors.initials: PK
authors.lastname: Sarma
authors.forename: Naresh
authors.initials: N
authors.lastname: Kumar
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D001665:Binding Sites / Q000187:drug effects; D003408:Cresols / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D015195:Drug Design; D008333:Mandelic Acids / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D010665:Phenylpropanolamine / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D043585:Receptor, Muscarinic M2 / Q000378:metabolism; D043587:Receptor, Muscarinic M3 / Q000378:metabolism; D013329:Structure-Activity Relationship; D000068737:Tolterodine Tartrate
chemical_list: D001559:Benzhydryl Compounds; D003408:Cresols; D008333:Mandelic Acids; D043585:Receptor, Muscarinic M2; D043587:Receptor, Muscarinic M3; D010665:Phenylpropanolamine; D000068737:Tolterodine Tartrate; C005419:oxybutynin