[Use of essentiale and cholagogum in prevention of cholelithiasis in fat hepatosis with concomitant cholecystitis].
OBJECTIVE
To assess efficacy of essentiale in combination with cholagogum in prevention of cholelithogenesis in patients with fat hepatosis (FH) and concomitant cholecystitis (CC).


METHODS
100 patients aged 31-60 years with FH and CC were examined using clinical, device and biochemical tests. The diagnosis was verified by the results of ultrasonography, computed and MR tomography. Fractionated duodenal tubing followed by biochemical examination of bile was conducted in all the patients.


RESULTS
Changes in physico-chemical properties of hepatic and vesical bile corresponding to stage I of cholelithiasis occurred in most of the examinees. Treatment with essentiale +cholagogum is clinically effective, improves functional condition of bile ducts and the liver, diminishes bile lithogenicity.


CONCLUSIONS
In fat hepatosis and concomitant cholecystitis, essentiale and cholagogum improve biochemical composition of bile, resulting finally in decreased risk of cholelithogenesis.
Vakhrushev
Ia M
IaM
Suchkova
E V
EV
D000328:Adult; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D002764:Cholecystitis / Q000150:complications* / Q000175:diagnosis / Q000517:prevention & control*; D002769:Cholelithiasis / Q000150:complications* / Q000175:diagnosis / Q000517:prevention & control*; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D005234:Fatty Liver / Q000150:complications* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010713:Phosphatidylcholines / Q000627:therapeutic use*; D010936:Plant Extracts / Q000627:therapeutic use*
D000924:Anticholesteremic Agents; D004338:Drug Combinations; D010713:Phosphatidylcholines; D010936:Plant Extracts; C038265:cholagogum; C011246:essential 303 forte