Kikuchi-Fujimoto disease associated with mixed connective tissue disease.
Kikuchi-Fujimoto disease is characterized by painful cervical lymphadenopathy and constitutional symptoms. Microscopical study of lymph nodes shows focal areas of non-suppurative necrosis with histiocytic and plasmacytoid cell infiltrates. The course is usually benign. Often primitive, necrotising histiocytic lymphadenopathy may be associated with autoimmune disorders. We describe the case of a 30-year-old female patient with two 15-day courses of Kikuchi-Fujimoto disease flares within a period of 3 months, occurring in association with mixed connective tissue disease.
Pallet
N
N
Department of Infectious and Tropical Diseases, Hopital Necker-Enfants Malades, Paris, France.
Aaron
L
L
Larousserie
F
F
Therby
A
A
Dupont
B
B
Viard
J-P
JP
D000328:Adult; D001707:Biopsy, Needle; D005500:Follow-Up Studies; D020042:Histiocytic Necrotizing Lymphadenitis / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008947:Mixed Connective Tissue Disease / Q000150:complications* / Q000175:diagnosis / Q000473:pathology*; D012075:Remission, Spontaneous; D018570:Risk Assessment; D012720:Severity of Illness Index