title: Cerebrospinal fluid MR dynamics and risk of falls in the elderly.
abstract: OBJECTIVE
  To investigate the relationship between CSF dynamics and risk of falls of unknown origin in the elderly.
  
  
  METHODS
  Phase contrast MR studies allowed CSF aqueductal flow quantification on 23 community-dwelling older people initially explored for mild cognitive impairment. Mobility assessment included report of falls, talking walking test, stance test, one leg standing test, up and go test, and measurement of fast gait speed.
  
  
  RESULTS
  History of falls was associated with larger aqueduct, steeper diastolic slopes higher ratios RDV/SD of diastolic volume/CSF systole duration (p</=0.0006). Amplitude CSF parameters, diastolic slopes and RDV/SD appeared correlated with the aqueduct area (p<0.01).
  
  
  CONCLUSIONS
  These preliminary data suggest that disturbances of CSF dynamics could play a role in mobility decline with aging especially in falls of unknown origin.
authors.affiliation: Department of Geriatrics, Bichat-Claude Bernard University Hospital, AP-HP, 46 rue Henri Huchard, 75877 Paris cedex 18, France. fannie.onen@bch.ap-hop-paris.fr
authors.forename: F
authors.initials: F
authors.lastname: Onen
authors.forename: M C Henry
authors.initials: MC
authors.lastname: Feugeas
authors.forename: G
authors.initials: G
authors.lastname: De Marco
authors.forename: G
authors.initials: G
authors.lastname: Baron
authors.forename: P
authors.initials: P
authors.lastname: Ravaud
authors.forename: S
authors.initials: S
authors.lastname: Legrain
authors.forename: J L
authors.initials: JL
authors.lastname: Moretti
authors.forename: E Schouman
authors.initials: ES
authors.lastname: Claeys
authors.forename: I Idy
authors.initials: II
authors.lastname: Peretti
mesh_terms: D000058:Accidental Falls; D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D002535:Cerebral Aqueduct / Q000502:physiology*; D002555:Cerebrospinal Fluid / Q000502:physiology*; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D004856:Postural Balance; D018570:Risk Assessment; D018709:Statistics, Nonparametric