Three-dimensional virtual microscopy of colorectal biopsies.
Conventional optical microscopy of specimens from colorectal biopsies commonly produces diagnostic errors due to incomplete sampling or poor orientation. Obtaining additional sections or re-embedding may help avoid these errors, but can prolong turnaround time. We describe new technology, which incorporates exhaustive sectioning, 3-dimensional reconstruction, and virtual microscopy, that may eliminate these problems by enabling pathologists to rapidly examine entire specimens and convert poorly oriented mucosa to well-oriented mucosa.
Wu
Mark Li-cheng
ML
Department of Pathology, University of California, Irvine School of Medicine, Irvine, USA. mlwu@uci.edu
Varga
Viktor Sebestyen
VS
Kamaras
Viktor
V
Ficsor
Levente
L
Tagscherer
Attila
A
Tulassay
Zsolt
Z
Molnar
Bela
B
D000368:Aged; D001706:Biopsy; D003111:Colonic Polyps / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000473:pathology*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008853:Microscopy / Q000379:methods*