Maintenance or interruption of pregnancy by human chorionic gonadotrophin in adrenalectomized albino rats.
In the present study, we investigated the efficacy of human chorionic gonadotrophin (HCG) in the maintenance of pregnancy in adrenalectomized rats. Holtzman's strain albino rats were adrenalectomized on day 8 of pregnancy and at the same time were laparotomized to observe the number of implantations. Adrenalectomy on day 8 caused abortions or fetal resorption in almost all rats. Administration of 5 or 50 IU HCG in adrenalectomized rats, from day 8 through 14 or 19, was not able to maintain gestation, resulting in fetal resorption with many placentomas and placental scars. However, a single injection of 5 IU or 1 IU HCG administered on day 8 only maintained the pregnancy to full term in adrenalectomized rats. Hence, the present experiment indicates that replacement therapy of a single dose of 5 IU or 1 IU HCG might be sufficient for maintaining pregnancy in adrenalectomized rats.
Nevagi
S A
SA
Department of Zoology, Karnatak University, Dharwad 580 003, India.
Vani
V
V
Doddamani
L S
LS
D000315:Adrenalectomy / Q000009:adverse effects*; D000818:Animals; D006063:Chorionic Gonadotropin / Q000009:adverse effects* / Q000494:pharmacology*; D005260:Female; D005327:Fetal Resorption / Q000139:chemically induced* / Q000378:metabolism; D006801:Humans; D011247:Pregnancy; D011255:Pregnancy Maintenance / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley
D006063:Chorionic Gonadotropin