Synthesis of 2-semicarbazonomethyl-4,5-methylenedioxyphenylacetic acids as anticonvulsant agents.
A series of 2-semicarbazonomethyl-4,5-methylenedioxyphenylacetic acids (12-19) were synthesized and tested as anticonvulsant agents in DBA/2 mice against sound-induced seizures and the results compared to those previously reported for the corresponding methyl esters (4-11). The new compounds possess anticonvulsant properties lower than those of 4-11, but, in some instances, comparable to that of GYKI 52466, a well-known noncompetitive AMPA receptor antagonist.
Micale
Nicola
N
Dipartimento Farmaco-Chimico, Università di Messina, Viale Annunziata, 98168 Messina, Italy. nmicale@pharma.unime.it <nmicale@pharma.unime.it>
Zappalà
Maria
M
Zuccalà
Giuseppe
G
Menniti
Frank S
FS
Ferreri
Guido
G
De Sarro
Giovambattista
G
Grasso
Silvana
S
D000085:Acetates / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D001569:Benzodiazepines / Q000494:pharmacology; D051379:Mice; D008811:Mice, Inbred DBA; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors; D012664:Semicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000085:Acetates; D000927:Anticonvulsants; D018091:Receptors, AMPA; D012664:Semicarbazones; C061950:GYKI 52466; D001569:Benzodiazepines