Synthesis of pyrazine alcaloids from Botryllus leachi. Diazines 43.
[reaction: see text] Regioselective metalation of pyrazines and cross-coupling reactions provides an easy access to botryllazines A and B and to an isomer of botryllazine A with good yields from chloropyrazine.
Buron
Frédéric
F
IRCOF, Laboratoire de Chimie Organique Fine et Hétérocyclique, UMR 6014, INSA, B.P. 08, 76131 Mont St. Aignan Cedex, France.
Plé
Nelly
N
Turck
Alain
A
Queguiner
Guy
G
D000470:Alkaloids / Q000138:chemical synthesis*; D000818:Animals; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry*; D014561:Urochordata / Q000737:chemistry*
D000470:Alkaloids; D011719:Pyrazines; C500475:botryllazine A; C500474:botryllazine B