title: Bronchial hyperresponsiveness and the bronchiolitis obliterans syndrome after lung transplantation.
abstract: Because bronchial hyperresponsiveness has been linked to the bronchiolitis obliterans syndrome (BOS), we determined PD(20) methacholine (PD(20(M))), PD(15) hypertonic saline (PD(15(HS))) and their dose-response slopes (DRS(M) and DRS(HS)) in 8 single and 18 double lung transplant recipients within 1 year of lung transplantation and examined the relationship to bronchoalveolar lavage cell profiles and subsequent development of BOS. Twenty-two patients (81%) had a positive methacholine and 6 (25%) a positive hypertonic saline challenge. A positive PD(15(HS)) was associated with an increased risk for BOS at 2 years (odds ratio 12.6, 95% confidence interval 1.3-123.5, p < 0.05), and time to BOS was significantly and negatively related to DRS(HS) (r = -0.5, p < 0.05) - that is, the greater the response, the shorter the time to BOS. Interestingly, DRS(HS) correlated positively with recipient:donor total lung capacity ratio (r = 0.5, p < 0.05), but there was no relationship between either challenge result and airway inflammation. Methacholine hyperresponsiveness is common after lung transplantation but is not prognostic, whereas response to hypertonic saline may reflect recipient:donor size matching and provide useful information regarding the potential for BOS development.
authors.affiliation: Lung Transplant Service, Department of Respiratory Medicine, The Alfred Hospital and Monash University, Melbourne, Australia. David.Reid@monash.edu.au
authors.forename: David W
authors.initials: DW
authors.lastname: Reid
authors.forename: E Haydn
authors.initials: EH
authors.lastname: Walters
authors.forename: David P
authors.initials: DP
authors.lastname: Johns
authors.forename: C
authors.initials: C
authors.lastname: Ward
authors.forename: Graham P
authors.initials: GP
authors.lastname: Burns
authors.forename: Pam
authors.initials: P
authors.lastname: Liakakos
authors.forename: Trevor J
authors.initials: TJ
authors.lastname: Williams
authors.forename: Greg I
authors.initials: GI
authors.lastname: Snell
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000368:Aged; D001706:Biopsy; D016535:Bronchial Hyperreactivity / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D001989:Bronchiolitis Obliterans / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D016085:Bronchoconstrictor Agents / Q000008:administration & dosage; D001999:Bronchoscopy; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D016210:Methacholine Chloride / Q000008:administration & dosage; D008875:Middle Aged; D011183:Postoperative Complications; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage; D014109:Total Lung Capacity
chemical_list: D016085:Bronchoconstrictor Agents; D012462:Saline Solution, Hypertonic; D016210:Methacholine Chloride