title: Platelet serotonin reuptake inhibition and response to SSRIs in depressed adolescents.
abstract: OBJECTIVE
  The authors examined platelet serotonin reuptake inhibition and response to selective serotonin reuptake inhibitor (SSRI) treatment in depressed adolescents.
  
  
  METHODS
  Twenty-three depressed adolescents participating in pharmacokinetic studies of SSRIs had platelet serotonin reuptake measured before and after 14-28 days of treatment. The Clinical Global Impression (CGI) improvement rating was determined on the basis of all clinical information and was performed blind to the platelet data.
  
  
  RESULTS
  Improvement in depressive symptoms as rated with the CGI improvement subscale was significantly associated with the percentage change in platelet serotonin reuptake inhibition from pre- to posttreatment. Improvement in depression was also associated with absolute decrease in platelet serotonin reuptake when adjusted for the magnitude of baseline reuptake.
  
  
  CONCLUSIONS
  Platelet serotonin reuptake inhibition may be an appropriate surrogate biological marker for the pharmacodynamic activity of SSRIs in depressed adolescents.
authors.affiliation: Western Psychiatric Institute and Clinic, 3811 O'Hara St., Pittsburgh, PA 15213, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Axelson
authors.forename: James M
authors.initials: JM
authors.lastname: Perel
authors.forename: Boris
authors.initials: B
authors.lastname: Birmaher
authors.forename: George
authors.initials: G
authors.lastname: Rudolph
authors.forename: Sharon
authors.initials: S
authors.lastname: Nuss
authors.forename: Linda
authors.initials: L
authors.lastname: Yurasits
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Bridge
authors.forename: David A
authors.initials: DA
authors.lastname: Brent
mesh_terms: D000293:Adolescent; D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002352:Carrier Proteins / Q000037:antagonists & inhibitors / Q000187:drug effects* / Q000378:metabolism; D003866:Depressive Disorder / Q000097:blood* / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D050486:Serotonin Plasma Membrane Transport Proteins; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D002352:Carrier Proteins; D050486:Serotonin Plasma Membrane Transport Proteins; D017367:Selective Serotonin Reuptake Inhibitors