The novel and efficient direct synthesis of N,O-acetal compounds using a hypervalent iodine(III) reagent: an improved synthetic method for a key intermediate of discorhabdins.
The use of hypervalent iodine(III) reagents allowed us to develop the novel and efficient direct synthesis of N,O-acetal compounds via the oxidative fragmentation reaction of alpha-amino acids or alpha-amino alcohols; furthermore, we succeeded in developing an improved synthesis of the key intermediate of discorhabdins.
Harayama
Yu
Y
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6, Yamada-oka, Suita, Osaka, 565-0871, Japan.
Yoshida
Masako
M
Kamimura
Daigo
D
Kita
Yasuyuki
Y
D000080:Acetals / Q000737:chemistry*; D000605:Amino Alcohols / Q000737:chemistry; D017613:Iodine Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry*; D011809:Quinones / Q000138:chemical synthesis / Q000737:chemistry*; D012694:Serine / Q000031:analogs & derivatives / Q000737:chemistry
D000080:Acetals; D000605:Amino Alcohols; D017613:Iodine Compounds; D011809:Quinones; D012694:Serine; C429009:serine methyl ester; D009584:Nitrogen; D010100:Oxygen