title: Cycloruthenated primary and secondary amines as efficient catalyst precursors for asymmetric transfer hydrogenation.
abstract: [reaction: see text] Ruthenacycles obtained by cyclometalation of enantiopure aromatic primary or secondary amines with [(eta6-benzene)RuCl2]2 or with [(eta6-p-cymene)RuCl2]2 are efficient catalysts for asymmetric transfer hydrogenation (TOF up to 190 h(-1) at room temperature). Enantioselectivities in the transfer hydrogenation of acetophenone ranged from 38% to 89%. It is possible to prepare the catalysts in situ, which allows the use of high throughput experimentation.
authors.affiliation: CNRS, UMR 7513, Laboratoire de Synthèses Métallo-Induites, Université Louis Pasteur, 4 rue Blaise Pascal, 67000 Strasbourg, France.
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Sortais
authors.forename: Vincent
authors.initials: V
authors.lastname: Ritleng
authors.forename: Adeline
authors.initials: A
authors.lastname: Voelklin
authors.forename: Alexandre
authors.initials: A
authors.lastname: Holuigue
authors.forename: Hakima
authors.initials: H
authors.lastname: Smail
authors.forename: Laurent
authors.initials: L
authors.lastname: Barloy
authors.forename: Claude
authors.initials: C
authors.lastname: Sirlin
authors.forename: Gerard K M
authors.initials: GK
authors.lastname: Verzijl
authors.forename: Jeroen A F
authors.initials: JA
authors.lastname: Boogers
authors.forename: André H M
authors.initials: AH
authors.lastname: de Vries
authors.forename: Johannes G
authors.initials: JG
authors.lastname: de Vries
authors.forename: Michel
authors.initials: M
authors.lastname: Pfeffer