[Studying the efficacy of a series of quinoxaline and azolo[a(b)]quinoxaline derivatives as P2X receptor antagonists].
The influence of a series of 14 quinoxaline and azoloquinoxaline derivatives on the P2X and P2Y receptor mediated response was studied in vitro on isolated rat and guinea pig tissues. Most of the compounds studied did not affect the response, while paratolylhydrazone-3-benzoyl-1,2-dihydro-2-oxoquinoxaline exhibited antagonism with respect to the P2X receptor mediated response, while not influencing the P2Y mediated relaxation. It is suggested that this compound can be used for the synthesis of new effective P2 receptor antagonists.
Ziganshin
A U
AU
Falu
Zh Iu
ZhIu
Kalinin
A A
AA
Mamedov
V A
VA
D000818:Animals; D006168:Guinea Pigs; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009924:Organ Culture Techniques; D058919:Purinergic P2 Receptor Antagonists; D011810:Quinoxalines / Q000494:pharmacology*; D051381:Rats; D058469:Receptors, Purinergic P2X
D058919:Purinergic P2 Receptor Antagonists; D011810:Quinoxalines; D058469:Receptors, Purinergic P2X