Round window membrane and labyrinthine pathological changes: an overview.
The round window membrane is considered the most likely pathway from the middle to the inner ear. Various substances placed in the middle ear have been seen to pass through the round window membrane. Once toxic substances or inflammatory mediators such as cytokines and nitric oxide enter the inner ear, various inner ear sequelae such as labyrinthitis, endolymphatic hydrops, sensorineural hearing loss or more insidious diseases can occur.
Cureoglu
Sebahattin
S
Department of Otolaryngology, University of Minnesota, Minneapolis, MN, USA.
Schachern
Patricia A
PA
Rinaldo
Alessandra
A
Tsuprun
Vladimir
V
Ferlito
Alfio
A
Paparella
Michael M
MM
D001424:Bacterial Infections / Q000150:complications; D001489:Basilar Membrane / Q000378:metabolism / Q000473:pathology*; D002463:Cell Membrane Permeability; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007762:Labyrinthitis / Q000378:metabolism / Q000382:microbiology / Q000473:pathology*; D009569:Nitric Oxide / Q000378:metabolism; D010033:Otitis Media / Q000378:metabolism / Q000473:pathology; D012405:Round Window, Ear / Q000378:metabolism / Q000473:pathology*
D016207:Cytokines; D009569:Nitric Oxide