Dihydrochalcones from the leaves of Pieris japonica.
Six new dihydrochalcones, 3-hydroxyasebotin (5), asebogenin 2'-O-beta-D-ribohexo-3-ulopyranoside (6), 2' '-acetylasebotin (7), 3',4,5'-trihydroxy-4'-methoxydihydrochalcone 3',5'-di-O-beta-D-glucopyranoside (8), and pierotins A (9) and B (10), along with four known dihydrochalcones, phloretin (1), phlorizin (2), asebogenin (3), and asebotin (4), were isolated from the leaves of Pieris japonica. Their structures were elucidated on the basis of spectroscopic analysis including HMQC, HMBC, NOESY, and X-ray crystal diffraction. Compounds 1, 3-5, and 7-10 inhibited the proliferation of murine B cells and compounds 5 and 10 inhibited the proliferation of murine T cells in vitro significantly.
Yao
Guang-Min
GM
Shanghai Institute of Materia Medica, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
Ding
Yu
Y
Zuo
Jian-Ping
JP
Wang
Hong-Bing
HB
Wang
Yu-Bo
YB
Ding
Bing-Yang
BY
Chiu
Pauline
P
Qin
Guo-Wei
GW
D000818:Animals; D002599:Chalcone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047188:Chalcones; D002681:China; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D029791:Ericaceae / Q000737:chemistry*; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013601:T-Lymphocytes / Q000187:drug effects*
D047188:Chalcones; D002599:Chalcone; C015812:dihydrochalcone