Hyaluronan chain conformation and dynamics.
An overview of the present state of research in the field of hyaluronan chain conformational aspects is presented. The relationship between structure and dynamics are illustrated for a series of hyaluronan oligomers. Conformational characteristics of hyaluronan chains are discussed, together with the dynamic chain patterns, evaluated by using a theoretical approach to diffusive polymer dynamics. The dependence of correlation times and NMR relaxation parameters from the chain dimension are investigated. Topological features and dimensional properties are related to the structural determinants by using classical computational methods of molecular mechanics and Monte Carlo simulation.
Furlan
Sara
S
Department of Biochemistry, Biophysics and Macromolecular Chemistry, UdR INSTM, University of Trieste, I-34127 Trieste, Italy.
La Penna
Giovanni
G
Perico
Angelo
A
Cesàro
Attilio
A
D002236:Carbohydrate Conformation; D006820:Hyaluronic Acid / Q000737:chemistry*; D009010:Monte Carlo Method; D019906:Nuclear Magnetic Resonance, Biomolecular
D006820:Hyaluronic Acid