title: Managing inflammatory reaction to restylane.
abstract: A 62-year-old woman received injections of Restylane, cross-linked hyaluronic acid, for the cosmetic filling of facial rhytids and developed a severe dermal inflammatory reaction. Hyaluronidase administered directly in the inflammatory nodules resulted in rapid resolution of pain, palpable nodularity, and visible induration possibly due to dissolution of the hyaluronic acid.
authors.affiliation: Plastic Eye Surgery Associates, PLLC, Houston, Texas 77030, USA. pesa_2004@sbcglobal.net
authors.forename: Charles N S
authors.initials: CN
authors.lastname: Soparkar
authors.forename: James R
authors.initials: JR
authors.lastname: Patrinely
mesh_terms: D003879:Dermatologic Agents / Q000009:adverse effects*; D005148:Facial Dermatoses / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D015745:Granuloma, Foreign-Body / Q000139:chemically induced / Q000188:drug therapy*; D006801:Humans; D006820:Hyaluronic Acid / Q000009:adverse effects* / Q000031:analogs & derivatives*; D006821:Hyaluronoglucosaminidase / Q000008:administration & dosage / Q000627:therapeutic use*; D015552:Injections, Intralesional; D008875:Middle Aged; D015361:Rhytidoplasty; D015595:Skin Aging
chemical_list: D003879:Dermatologic Agents; D006820:Hyaluronic Acid; D006821:Hyaluronoglucosaminidase; C445361:Restylane