[Th1/Th2 balance in acute lymphoblastic leukemia in children].
Analysis of T lymphocytes cytokine profiles allows to differ subpopulations: Th1, Th2, Th3, Tr1. Aim of the study was to assess Th1/Th2 balance in acute lymphoblastic leukemia in children at diagnosis and during/after remission induction, especially during infections. Percentages of lymphocytes T producing IFN-gamma and IL-4 were assessed by flow cytometry. We noted the rise of lymphocytes T helper producing IFN-gamma (Th1) and percentage of lymphocytes T producing IL-4 at the beginning and during remission induction was higher than in control group. During fever/infection we observed the rise of lymphocytes Th1, and no change in Th2 percentage. Summarizing we suggest Th1/Th2 imbalance and Th2 predominance in acute lymphoblastic leukemia in children.
Luczyński
Włodzimierz
W
Klinika Onkologii Dzieciecej, Samodzielny Publiczny Dzieciecy, Szpital Kliniczny Akademii Medycznej w Białymstoku. vlodek@amb.edu.pl
Stasiak-Barmuta
Anna
A
Krawczuk-Rybak
Maryna
M
Malinowska
Iwona
I
Matysiak
Michał
M
Mitura-Lesiuk
Małgorzata
M
Kowalczyk
Jerzy
J
Jeromin
Agnieszka
A
D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D018655:Lymphocyte Count; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology*; D012074:Remission Induction; D018417:Th1 Cells / Q000378:metabolism*; D018418:Th2 Cells / Q000378:metabolism*
D015847:Interleukin-4; D007371:Interferon-gamma