Results of a multicenter clinical trial to evaluate the preferential hyperacuity perimeter for detection of age-related macular degeneration.
OBJECTIVE
To compare the preferential hyperacuity perimeter (PHP) with an Amsler grid in detection of age-related macular degeneration (AMD).


METHODS
Patients underwent refraction, visual acuity examination, PHP, Amsler grid examination, and macular photography.


RESULTS
One hundred fifty patients participated in the trial. Of 19 eyes with neovascular AMD, 19 (100%) were positive on the PHP, and 10 (53%), on the Amsler grid. Of 27 eyes with geographic atrophy, 26 (96%) were positive on the PHP, and 12 (44%), on the Amsler grid. Of 20 eyes with intermediate AMD, 14 (70%) were positive on the PHP, and 4 (20%), on the Amsler grid. Of 51 eyes with early AMD, 21 (41%) were positive on the PHP, and 4 (8%), on the Amsler grid. Of 33 eyes with no AMD, 6 (18%) were positive on the PHP, and none, on the Amsler grid. Thus, 80 (68%) of 117 patients with AMD had a positive PHP, while 30 (26%) had positive results of Amsler grid examination (P < 0.001, McNemar test).


CONCLUSIONS
The PHP had greater sensitivity, although with a relatively high rate of false-positive results for healthy individuals, than the Amsler grid in detecting AMD-related lesions.
Goldstein
Michaela
M
Department of Ophthalmology, Tel-Aviv Medical Center, Israel.
Loewenstein
Anat
A
Barak
Adiel
A
Pollack
Ayala
A
Bukelman
Amir
A
Katz
Haia
H
Springer
Amira
A
Schachat
Andrew P
AP
Bressler
Neil M
NM
Bressler
Susan B
SB
Cooney
Michael J
MJ
Alster
Yair
Y
Rafaeli
Omer
O
Malach
Rafael
R
D000368:Aged; D000369:Aged, 80 and over; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D010781:Photography / Q000379:methods; D011237:Predictive Value of Tests; D012029:Refraction, Ocular; D012680:Sensitivity and Specificity; D014792:Visual Acuity; D058609:Visual Field Tests / Q000379:methods*