Post-transplant lymphoproliferative disorder of the cervix.
BACKGROUND
Post-transplant lymphoproliferative disorder involving the female genital tract is a rare event.


METHODS
A 67-year-old female status post orthotopic liver transplant 5 years previously for hepatitis B and sarcoidosis presented with vaginal bleeding. Endometrial biopsy revealed a high-grade malignant tumor with immunologic marker studies consistent with lymphoma. The patient underwent an exploratory laparotomy, modified radical hysterectomy, bilateral salpingo oophorectomy, bilateral selective pelvic and para-aortic lymphadenectomy, and omentectomy. Final pathology confirmed monomorphic B-cell post-transplantation lymphoproliferative disorder consistent with non-Hodgkin's B cell lymphoma confined to the endocervix and lower uterine segment. She remains recurrence free after 4 years with no adjuvant therapy.


CONCLUSIONS
Post-transplant complications can present in the female reproductive organs. Gynecologic oncologists need to be aware of this disease process when treating patients for gynecologic symptoms after transplant surgery.
Nagarsheth
Nimesh P
NP
Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai Medical Center, 1176 Fifth Avenue, Box 1173, New York, NY 10029-6574, USA. nimesh.nagarsheth@mssm.edu
Kalir
Tamara
T
Rahaman
Jamal
J
D000368:Aged; D005260:Female; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D016393:Lymphoma, B-Cell / Q000209:etiology*; D008232:Lymphoproliferative Disorders / Q000209:etiology*; D002583:Uterine Cervical Neoplasms / Q000209:etiology*