title: Sonothrombolysis in acute ischemic stroke for patients ineligible for rt-PA.
abstract: The authors studied the effect of transcranial ultrasound on patients with acute middle cerebral artery occlusion and contraindications for thrombolysis. Fifteen consecutive subjects were randomized for insonation over 1 hour or for inclusion in a control group. By day 4, recanalization and neurologic improvement occurred more frequently in the target group. Ultrasound-induced acceleration of clot dissolution may be an option for patients with contraindications for recombinant tissue plasminogen activator.
authors.affiliation: Department of Neurology, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Eggers
authors.forename: Günter
authors.initials: G
authors.lastname: Seidel
authors.forename: Björn
authors.initials: B
authors.lastname: Koch
authors.forename: Inke R
authors.initials: IR
authors.lastname: König
mesh_terms: D000208:Acute Disease / Q000628:therapy; D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000628:therapy*; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000000981:diagnostic imaging* / Q000628:therapy*; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D010865:Pilot Projects; D020127:Recovery of Function; D015912:Thrombolytic Therapy / Q000295:instrumentation / Q000379:methods*; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000628:therapy; D010959:Tissue Plasminogen Activator / Q000009:adverse effects; D016896:Treatment Outcome; D014464:Ultrasonic Therapy / Q000379:methods*; D014463:Ultrasonography
chemical_list: D010959:Tissue Plasminogen Activator