title: Inhibitory activity of isorhamnetin from Persicaria thunbergii on Farnesyl Protein Transferase.
abstract: The methanolic extract of the aerial parts of Persicaria thunbergii was found to show inhibitory activity on Farnesyl Protein Transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of isorhamnetin, as an inhibitor on FPTase. This compound inhibited FPTase activity in a dose-dependent manner, and the IC50 value of isorhamnetin was 37.5 microM.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology, KIST, Taejeon 305-333, Korea.
authors.forename: Hyun Mi
authors.initials: HM
authors.lastname: Oh
authors.forename: Byoung-Mog
authors.initials: BM
authors.lastname: Kwon
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Kim
authors.forename: In-Sik
authors.initials: IS
authors.lastname: Chung
authors.forename: Mi-Hyun
authors.initials: MH
authors.lastname: Park
authors.forename: Hee Wook
authors.initials: HW
authors.lastname: Park
authors.forename: Jae Hyeok
authors.initials: JH
authors.lastname: Lee
authors.forename: Hye Won
authors.initials: HW
authors.lastname: Park
authors.forename: Eun Jeong
authors.initials: EJ
authors.lastname: Kim
authors.forename: Dae Keun
authors.initials: DK
authors.lastname: Kim
mesh_terms: D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D002855:Chromatography, Thin Layer; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D051231:Farnesyltranstransferase; D044948:Flavonols / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000494:pharmacology; D019664:Polygonaceae / Q000737:chemistry*; D011794:Quercetin / Q000031:analogs & derivatives
chemical_list: D004791:Enzyme Inhibitors; D044948:Flavonols; D010936:Plant Extracts; C047368:3-methylquercetin; D011794:Quercetin; D019883:Alkyl and Aryl Transferases; D051231:Farnesyltranstransferase