title: Clinical toxicology study of an herbal medicinal extract of Paullinia cupana, Trichilia catigua, Ptychopetalum olacoides and Zingiber officinale (Catuama) in healthy volunteers.
abstract: In Brazil, a herbal medicinal extract named Catuama containing a mixture of Paullinia cupana (guarana; Sapindaceae), Trichilia catigua (catuaba; Meliaceae), Ptychopetalum olacoides (muirapuama; Olacaceae) and Zingiber officinale (ginger; Zingiberaceae) is used as a body stimulant, energetic, tonic and aphrodisiac. The present study investigated the chronic administration of 25 mL Catuama twice a day during 28 days for any toxic effect on healthy human volunteers of both sexes. No severe adverse reactions or haematological and biochemical changes were reported.
authors.affiliation: Miguel Servet Clinical Pharmacology Unit, 415 Jesuíno Marcondes Machado Avenue, Campinas, SP 13092-320, Brazil. oliveira_ch@terra.com.br
authors.forename: Celso H
authors.initials: CH
authors.lastname: Oliveira
authors.forename: Maria Elizabete A
authors.initials: ME
authors.lastname: Moraes
authors.forename: Manoel O
authors.initials: MO
authors.lastname: Moraes
authors.forename: Fernando A F
authors.initials: FA
authors.lastname: Bezerra
authors.forename: Eduardo
authors.initials: E
authors.lastname: Abib
authors.forename: Gilberto
authors.initials: G
authors.lastname: De Nucci
mesh_terms: D000328:Adult; D001774:Blood Chemical Analysis; D005260:Female; D020939:Zingiber officinale; D006801:Humans; D008297:Male; D029582:Meliaceae; D031656:Olacaceae; D032126:Paullinia; D008517:Phytotherapy; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology*; D010946:Plants, Medicinal; D012016:Reference Values
chemical_list: C437663:Catuama; D010936:Plant Extracts