Antimetastatic activity of a synthetic serine protease inhibitor, FOY-305 (Foypan).
Metastasis is one of the major causes of mortality in cancer. It is well known that the activities of cell surface serine proteases are especially enhanced in malignant tumors. Proteolytic degradation of the extracellular matrix and basal membrane is a crucial event for tumor cell invasion and metastasis formation. FOY-305 (Foypan), a remedy for tumor pancreatitis, is a broad spectrum synthetic serine protease inhibitor which inhibits enzymatic activities including trypsin, thrombin, kallikrein and plasmin. Using Lewis lung carcinoma cell, we found that FOY-305 inhibited both spontaneous and experimental pulmonary metastasis. Furthermore, the combined treatment of FOY-305 and a traditional anti-cancer drug, 5-FU or bleomycin, resulted in marked enhancement of anti-pulmonary metastatic activity.
Ohkoshi
Motohiro
M
Department of Health Care, Showagakuin University, Arakino 3-29-20, Abiko-shi, Japan.
Sasaki
Yutaro
Y
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology; D001761:Bleomycin / Q000494:pharmacology; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy*; D004952:Esters; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology; D016670:Gabexate / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006146:Guanidines; D008175:Lung Neoplasms / Q000517:prevention & control* / Q000556:secondary*; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology*
D000964:Antimetabolites, Antineoplastic; D004952:Esters; D006146:Guanidines; D015842:Serine Proteinase Inhibitors; C034532:camostat; D001761:Bleomycin; D016670:Gabexate; D005472:Fluorouracil