Markers of inflammation in preeclampsia.
Advanced oxidation protein products (AOPP) represent terminal products of proteins exposure to free radicals. The aim of this study was to estimate the serum AOPP levels in preeclamptic patients together with ultrasensitive C-reactive protein and anticardiolipin antibodies (ACA) IgG and IgM. 21 women in the third trimester of pregnancy were included in the study--10 women with preeclampsia and 11 women with normal outcome of pregnancy. AOPP levels in preeclampsia were higher than those in normal pregnant women in the third trimester, but not statistically significantly. The comparison with AOPP levels in non-pregnant women has shown a significant increase (P<0.0001). CRP in preeclampsia was significantly increased in comparison with third trimester levels in normal pregnancy (P<0.001) as well as with non-pregnant women (P<0.0001). In preeclampsia, the ACA IgG levels were even significantly lower than in normal pregnant women in the same gestation age, but significantly higher than in non-pregnant women (P<0.001). No difference was found in ACA IgM in preeclampsia and normal third trimester pregnancy and non-pregnant women. A statistically significant negative correlation was found between AOPP and ACA IgG (r= - 0.708, P<0.05). The results indicate enhanced oxidative and inflammatory reaction of maternal organism to pregnancy, which is more pronounced in preeclampsia than in uncomplicated pregnancy.
Fialová
L
L
Institute of Medical Biochemistry of the First Faculty of Medicine, Charles University in Prague, Czech Republic. lfial@lf1.cuni.cz
Kalousová
M
M
Soukupová
J
J
Malbohan
I
I
Madar
J
J
Frisová
V
V
Stípek
S
S
Zima
T
T
D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism*; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007249:Inflammation; D018836:Inflammation Mediators / Q000097:blood*; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy
D017153:Antibodies, Anticardiolipin; D015415:Biomarkers; D001798:Blood Proteins; D005609:Free Radicals; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D018836:Inflammation Mediators; D002097:C-Reactive Protein