title: Late liver-related mortality from complications of transfusion-acquired hepatitis C.
abstract: Although several cohort studies have been reported in individuals with chronic hepatitis C virus (HCV) infection, little is known about liver-related mortality among the elderly. We conducted a cohort study in 302 patients with tuberculosis sequelae who had received a blood transfusion at a young age and had subsequently been treated at a chest clinic. The cohort consisted of 147 patients with antibody to HCV (anti-HCV), of whom 81% were positive for HCV RNA, and 155 without anti-HCV. The cohort was followed for a mean duration of 5.7 years. There were no differences between the two groups in the mean age of the patients at the time of transfusion (31 vs. 34 years) or at the time of entry into the study (65 vs. 66 years). The outcome of 143 patients with, and 145 without, anti-HCV could be traced; 92 (64%) and 82 (57%) had died, respectively. The main cause of death was tuberculosis sequelae in 61 (42%) and 66 (46%) patients, respectively. Eight (6%) of the 143 patients with anti-HCV died of liver disease (hepatocellular carcinoma: seven; rupture of varices: one). The average annual mortality from liver disease from study entry in the patients with anti-HCV was 9.8 per 1,000 person-years. The patients with anti-HCV had a significantly lower cause-specific survival probability for liver disease (92% vs. 100% at 10 years, P < .005). In conclusion, in our study, liver-related mortality appeared to be high among elderly HCV-infected individuals.
authors.affiliation: Department of Gastroenterology, Tokyo National Hospital, Tokyo, Japan. kamihiro@tokyo.hosp.go.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kamitsukasa
authors.forename: Hideharu
authors.initials: H
authors.lastname: Harada
authors.forename: Hideo
authors.initials: H
authors.lastname: Tanaka
authors.forename: Michiyasu
authors.initials: M
authors.lastname: Yagura
authors.forename: Hajime
authors.initials: H
authors.lastname: Tokita
authors.forename: Akira
authors.initials: A
authors.lastname: Ohbayashi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D016174:Hepacivirus / Q000235:genetics / Q000276:immunology; D006526:Hepatitis C / Q000150:complications / Q000209:etiology*; D018937:Hepatitis C Antibodies / Q000097:blood; D006801:Humans; D008107:Liver Diseases / Q000401:mortality* / Q000503:physiopathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood; D016019:Survival Analysis; D065227:Transfusion Reaction; D014376:Tuberculosis / Q000209:etiology / Q000401:mortality
chemical_list: D018937:Hepatitis C Antibodies; D012367:RNA, Viral