A probabilistic functional atlas of the human subthalamic nucleus.
This paper introduces a method for generation and validation of a probabilistic functional brain atlas of subcortical structures from electrophysiological and neuroimaging data. The method contains three major steps: (1) acquisition of pre, intra, and postoperative multimodal data; (2) selection of an accurate data set for atlas generation; and (3) generation of the atlas from the selected data set. The method is applied to construct the probabilistic functional atlas of the human subthalamic nucleus (STN). The STN atlas has been built from data collected during surgical treatment of 184 patients with Parkinson's disease. It is based on preoperative X-ray ventriculography imaging, intraoperative electrophysiological measurements and X-ray imaging, and postoperative neurological assessment. The atlas features a high resolution of 0.25 mm(3) and a high accuracy of 0.25 mm. It is dynamic and can be rapidly recalculated for arbitrary resolution and extended by adding new patient data. The atlas can easily be reformatted and warped to match patient-specific data. Its applications include planning of subthalamic stimulations and neuroscience research to study functional properties of the STN. The presented method is general and can be applied for constructing human and animal probabilistic brain atlases.
Nowinski
Wieslaw L
WL
Biomedical Imaging Lab, Institute for Infocomm Research 21 Heng Hui Keng Terrace, Singapore. wieslaw@bii-a-star.edu.sg
Belov
Dmitry
D
Pollak
Pierre
P
Benabid
Alim Louis
AL
D000716:Anatomy, Artistic; D001931:Brain Mapping; D004292:Dominance, Cerebral / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008488:Medical Illustration; D011336:Probability; D015203:Reproducibility of Results; D013238:Stereotaxic Techniques; D020531:Subthalamic Nucleus / Q000502:physiology*