title: Polymorphism of the adrenergic receptor alpha 2a -1291C>G genetic variation and clozapine-induced weight gain.
abstract: Weight gain, leading to further morbidity and poor treatment compliance, is a common consequence of treatment with clozapine. The substantial interindividual and interracial differences in drug-induced weight gain suggest that genetic factors may be important. Several studies showed that alpha-2, adrenoceptor may related to feeding behavior with rat or lipolytic activity of human adipocyte tissue, they are related to body weight change. In the study, we try to test the possible relation of clozapine-induced weight gain and adrenergic receptor alpha 2a -1291C>G genetic polymorphism in a long term follow up (14.0 +/- 6.2 months). Our results show the genotype GG (8.45 +/- 7.2 Kg) with higher mean body weight gain than genotype CC (2.79 +/- 6.1 Kg) (p = 0.023). The finding identify a genetic factor associated with clozapine-induced weight gain in schizophrenic patients.
authors.affiliation: Department of Psychiatry, Yu-Li Veterans Hospital, Taipei, Taiwan, Republic of China.
authors.forename: Y-C
authors.initials: YC
authors.lastname: Wang
authors.forename: Y-M
authors.initials: YM
authors.lastname: Bai
authors.forename: J-Y
authors.initials: JY
authors.lastname: Chen
authors.forename: C-C
authors.initials: CC
authors.lastname: Lin
authors.forename: I-C
authors.initials: IC
authors.lastname: Lai
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Liou
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects; D001483:Base Sequence / Q000235:genetics; D003024:Clozapine / Q000009:adverse effects*; D003596:Cytosine / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D006147:Guanine / Q000378:metabolism; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000139:chemically induced / Q000235:genetics / Q000503:physiopathology; D017354:Point Mutation / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D018341:Receptors, Adrenergic, alpha-2 / Q000187:drug effects* / Q000235:genetics*; D015430:Weight Gain / Q000187:drug effects* / Q000502:physiology
chemical_list: C547768:ADRA2A protein, human; C547770:Adra2a protein, rat; D014150:Antipsychotic Agents; D018341:Receptors, Adrenergic, alpha-2; D006147:Guanine; D003596:Cytosine; D003024:Clozapine