Direct conversion of N-methoxy-N-methylamides (Weinreb amides) to ketones via a nonclassical Wittig reaction.
[reaction: see text] N-Methoxy-N-methylamides (Weinreb amides) are converted efficiently into ketones by reaction with alkylidenetriphenylphosphoranes and in situ hydrolysis of the product.
Murphy
John A
JA
Department of Pure and Applied Chemistry, University of Strathclyde, Thomas Graham Building, 295 Cathedral Street, Glasgow G1 1XL, UK. john.murphy@strath.ac.uk
Commeureuc
Aurélien G J
AG
Snaddon
Thomas N
TN
McGuire
Thomas M
TM
Khan
Tanweer A
TA
Hisler
Kevin
K
Dewis
Mark L
ML
Carling
Robert
R