title: Protein serine/threonine phosphatases: life, death, and sleeping.
abstract: Protein serine/threonine phosphatases control key biological pathways including early embryonic development, cell proliferation, cell death, circadian rhythm and cancer. Recent studies have provided important insights into how several of the many phosphatase regulators, through their interaction with a conserved phosphatase catalytic subunit, control the activity of critical substrates in these diverse pathways. Recent co-crystal structures provided a major insight into how the diverse protein serine/threonine regulators rein in the otherwise promiscuous catalytic subunits.
authors.affiliation: Huntsman Cancer Institute, 2000 Circle of Hope, University of Utah, Salt Lake City, Utah 84112, USA.
authors.forename: Monica
authors.initials: M
authors.lastname: Gallego
authors.forename: David M
authors.initials: DM
authors.lastname: Virshup
mesh_terms: D000818:Animals; D020134:Catalytic Domain / Q000502:physiology*; D016923:Cell Death / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D002940:Circadian Rhythm / Q000502:physiology; D018360:Crystallography, X-Ray; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology*; D008958:Models, Molecular; D010749:Phosphoprotein Phosphatases / Q000737:chemistry / Q000378:metabolism*; D017434:Protein Structure, Tertiary / Q000502:physiology
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D010749:Phosphoprotein Phosphatases