Translational complexity of the fragile x mental retardation protein: insights from the fly.
Through the awesome power of Drosophila genetics, two recent studies reveal novel mechanisms by which the Fragile X Mental Retardation protein regulates selective mRNA translation, controlling key steps of germline development during oogenesis and neuronal development during synaptogenesis.
Broadie
Kendal
K
Department of Biological Sciences, Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee 37232, USA.
Pan
Luyuan
L
D000818:Animals; D004330:Drosophila / Q000235:genetics*; D051860:Fragile X Messenger Ribonucleoprotein 1; D005600:Fragile X Syndrome / Q000235:genetics*; D005854:Germ Cells / Q000166:cytology / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D009866:Oogenesis; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000235:genetics*
D051860:Fragile X Messenger Ribonucleoprotein 1; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D016601:RNA-Binding Proteins