Cerylimycins [corrected] A and B: antibacterial triterpenes from the new species Tricholoma sp. AU1.
To new triterpenes, trichomycins A (1) and B (2), were purified from the new species Tricholoma sp. AU1 by activity-guided fractionation following their antibacterial activity. The two compounds were found to have a hitherto unreported triterpenoid skeleton. The structures and relative stereochemistry of 1 and 2 were determined through extensive 2D NMR spectroscopy, while the inhibitory activity of 1 and 2 against two Gram-positive and two Gram-negative bacteria and a mammalian cell line was determined.
Ovenden
Simon P B
SP
Cerylid Biosciences, 576 Swan Street Richmond, Victoria, 3121, Australia.
Yu
Jin
J
Bernays
Jill
J
Wan
Soo San
SS
Christophidis
Larissa J
LJ
Sberna
Gian
G
Tait
R Murray
RM
Wildman
Howard G
HG
Lebeller
Dominique
D
Platel
Denis
D
May
Tom W
TW
Meurer-Grimes
Barbara M
BM
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001315:Australia; D001487:Basidiomycota / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000900:Anti-Bacterial Agents; D014315:Triterpenes; C499930:trichomycin B; C499929:trichomycin A