title: Cyclic bisphosphonate therapy in osteogenesis imperfecta type V.
abstract: The clinical and radiographic features and management of a young person with recently delineated Osteogenesis Imperfecta Type V is described. A female aged 9 years presented with a history of multiple fractures since 3 years of age and bilateral dislocation of the elbows from infancy. She was commenced on a low dose frequent regimen of cyclic intravenous pamidronate, which resulted in progressive improvement in bone density, reduced fracture frequency and remission of symptoms of osteoporosis.
authors.affiliation: Department of Clinical Genetics, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
authors.forename: F
authors.initials: F
authors.lastname: Fleming
authors.forename: H J
authors.initials: HJ
authors.lastname: Woodhead
authors.forename: J N
authors.initials: JN
authors.lastname: Briody
authors.forename: J
authors.initials: J
authors.lastname: Hall
authors.forename: C T
authors.initials: CT
authors.lastname: Cowell
authors.forename: J
authors.initials: J
authors.lastname: Ault
authors.forename: K
authors.initials: K
authors.lastname: Kozlowski
authors.forename: D O
authors.initials: DO
authors.lastname: Sillence
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002648:Child; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D010013:Osteogenesis Imperfecta / Q000145:classification / Q000000981:diagnostic imaging / Q000188:drug therapy*; D000077268:Pamidronate; D011859:Radiography; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D004164:Diphosphonates; D000077268:Pamidronate