title: [Latanoprost topical ophthalmic combinations].
abstract: Latanoprost became the first line therapeutic agent in glaucoma treatment being the best sold worldwide anti-glaucoma medication. When adequate intraocular pressure decrease can not be achieved with latanoprost monotherapy, then its combinations are to be used. Latanoprost combinations are grouped in to non-fixed and fixed variants. Non-fixed combinations mean concomitant therapy,that is giving the two or more medications using different bottles. The medications used for latanoprost non-fixed combinations are represented by timolol 0.5%, pilocarpine 2%, acetazolamide dispensed systemically and locally, dipivefrin 0.1%, unoprostone 0.12% and brimonidine 0.2%. Fixed combinations mean administering the two mixed medications using one single bottle. At the present time there is only one fixed combination of latanoprost i.e. its combination with timolol 0.5% whose trading name is Xalcom.
authors.forename: M
authors.initials: M
authors.lastname: Călugăru
authors.forename: D
authors.initials: D
authors.lastname: Călugăru
mesh_terms: D000086:Acetazolamide / Q000627:therapeutic use; D000287:Administration, Topical; D000959:Antihypertensive Agents / Q000627:therapeutic use; D000068438:Brimonidine Tartrate; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D004837:Epinephrine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D000077338:Latanoprost; D009798:Ocular Hypertension / Q000188:drug therapy; D009883:Ophthalmic Solutions; D010862:Pilocarpine / Q000627:therapeutic use; D011461:Prostaglandins F, Synthetic / Q000627:therapeutic use*; D011810:Quinoxalines / Q000627:therapeutic use; D013999:Timolol / Q000627:therapeutic use
chemical_list: D000959:Antihypertensive Agents; D004338:Drug Combinations; D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic; D011810:Quinoxalines; D010862:Pilocarpine; D000068438:Brimonidine Tartrate; C072630:isopropyl unoprostone; D000077338:Latanoprost; D013999:Timolol; C015173:dipivefrin; D015237:Dinoprost; D000086:Acetazolamide; D004837:Epinephrine