Use of mitomycin C for treatment of keloid: a preliminary report.
OBJECTIVE
Mitomycin C (MC) is an anti-neoplastic agent with an anti-proliferative effect on fibroblasts. We set out to evaluate the effect of MC application following keloid excision.


METHODS
Patients with keloid in a tertiary referral center were enrolled in a prospective study. The scar was excised and prior to skin closure, a pledget with 1 cc of MC 0.4 mg/mL was applied for 5 minutes. Patient satisfaction and keloid thickness were assessed.


RESULTS
All patients were satisfied with the results, although complete disappearance of the keloid was evident only in two. Keloid thickness was measured and ranged from 5 to 26 mm. Following surgery and treatment at 2 months thickness ranged from 0 to 8 mm.


CONCLUSIONS
MC application following scar resection appears to be effective in treatment of keloid.


CONCLUSIONS
As no specific effective treatment for keloid is currently available, utilization of this readily available therapeutic agent may improve treatment outcome.
Talmi
Yoav P
YP
Department of Otolaryngology--Head and Neck Surgery, Chaim Sheba Medical Center, Tel Hashomer, Israel. yoav.talmi@sheba.health.gov.il
Orenstein
Arie
A
Wolf
Michael
M
Kronenberg
Jona
J
D000293:Adolescent; D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000009:adverse effects; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007627:Keloid / Q000188:drug therapy* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage* / Q000009:adverse effects; D019384:Nucleic Acid Synthesis Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D010038:Otorhinolaryngologic Diseases / Q000188:drug therapy* / Q000601:surgery; D011446:Prospective Studies; D016896:Treatment Outcome
D000903:Antibiotics, Antineoplastic; D019384:Nucleic Acid Synthesis Inhibitors; D016685:Mitomycin