Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines.
From the rhizomes of Belamcanda chinensis, three new compounds, belalloside A (1), belalloside B (2), and belamphenone (3), along with 13 known compounds, resveratrol (4), iriflophenone (5), irisflorentin (6), tectorigenin (7), irilin D (8), tectoridin (9), iristectorin A (10), iristectorin B (11), hispiduloside, androsin, irigenin, iridin, and jaceoside, have been isolated and characterized. Isolates were evaluated for their cell proliferation stimulatory activity against the MCF-7 and T-47D human breast cancer cell lines. Along with 4, 5, 7, and 9, 3 was shown to stimulate not only MCF-7 but also T-47D human breast cancer cell proliferation.
Monthakantirat
Orawan
O
Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
De-Eknamkul
Wanchai
W
Umehara
Kaoru
K
Yoshinaga
Yohko
Y
Miyase
Toshio
T
Warashina
Tsutomu
T
Noguchi
Hiroshi
H
D001943:Breast Neoplasms; D049109:Cell Proliferation / Q000187:drug effects; D005260:Female; D006801:Humans; D027621:Iridaceae / Q000737:chemistry*; D007529:Isoflavones / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D000077185:Resveratrol; D027343:Rhizome / Q000737:chemistry; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013785:Thailand; D014407:Tumor Cells, Cultured / Q000187:drug effects
D007529:Isoflavones; D010636:Phenols; D013267:Stilbenes; C499934:belalloside A; C499935:belalloside B; C499936:belamphenone; C570745:irisflorentin; D000077185:Resveratrol