Programmed cell death in the embryonic vertebrate limb.
The developing limb bud provides one of the best examples in which programmed cell death exerts major morphogenetic functions. In this work, we revise the distribution and the developmental significance of cell death in the embryonic vertebrate limb and its control by the BMP signalling pathway. In addition, paying special attention to the interdigital apoptotic zones, we review current data concerning the intracellular death machinery implicated in mesodermal limb apoptosis.
Zuzarte-Luis
Vanessa
V
Departamento de Anatomia y Biologia Celular, Universidad de Cantabria, C/Cardenal Herrera Oria, s/n, 39011 Santander, Cantabria, Spain.
Hurle
Juan M
JM
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D002642:Chick Embryo; D004372:Ducks / Q000196:embryology; D004475:Ectoderm / Q000502:physiology; D005121:Extremities / Q000196:embryology* / Q000502:physiology; D008648:Mesoderm / Q000502:physiology; D051379:Mice; D015398:Signal Transduction / Q000502:physiology
D019485:Bone Morphogenetic Proteins