[Role of nitric oxide in effects of intramedullary injected gamma-aminobutyric acid on blood circulation].
In acute experiments on anaesthetized with urethane normotensive rats, we studied the influence of modulation of neuronal NO-synthase (nNOS) activity on the effects of GABA injected in the populations of cardiovascular neurons within the nucleus of tractus solitarius (NTS), n.ambiguus (AMB), paramedian reticular nucleus (PMn) and lateral reticular nucleus (LRN). The data obtained give evidence for nNOS involvement in the effects of intramedullary injected GABA on the cardiovascular system.
Shapoval
L M
LM
Sahach
V F
VF
Pobihaĭlo
L S
LS
Stepanenko
L H
LH
Iermolins'ka
N V
NV
D000818:Animals; D001921:Brain / Q000098:blood supply / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects* / Q000502:physiology; D008845:Microinjections; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D052248:Nitric Oxide Synthase Type I; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000494:pharmacology*
D009419:Nerve Tissue Proteins; D009569:Nitric Oxide; D005680:gamma-Aminobutyric Acid; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I; C496322:Nos1 protein, rat