title: Anthecotulide: purification, analytical data, absence from chamomile preparations, stability and reactivity, and anti-infective testing.
abstract: The sesquiterpene lactone anthecotulide (1) was extracted from Anthemis cotula in 0.7% w/w yield. A pure standard was prepared by preparative TLC and used for quantitative determination of 1 with a TLC scanner. The constitution of 1 was corroborated and the double-bond configuration determined. It was stable at room temparature in air and reacted very slowly with glutathione. It was not detectable in 34 chamomile (Matricaria recutita) preparations and did not show antibacterial activity against a range of clinically important strains at a concentration of <10 microg/mL.
authors.affiliation: Institut für Pharmazeutische Chemie der Martin-Luther-Universität Halle, Wolfgang-Langenbeck-Strasse 4, D-06120 Halle, Germany.
authors.forename: Achim
authors.initials: A
authors.lastname: Meyer
authors.forename: Stefan
authors.initials: S
authors.lastname: Zimmermann
authors.forename: Bernd
authors.initials: B
authors.lastname: Hempel
authors.forename: Peter
authors.initials: P
authors.lastname: Imming
mesh_terms: D031166:Anthemis / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020843:Chamomile; D002855:Chromatography, Thin Layer; D005858:Germany; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D007783:Lactones; D012717:Sesquiterpenes; C499300:anthecotulide