Hydrophilized poly(lactide-co-glycolide) nanospheres with poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer.
A novel method for preparing the PLGA nanospheres with hydrophilic surface has been designed and characterized. Because of good solubility of tetraglycol in water, PLGA (poly(lactide-co-glycolide)) nanospheres were formed by spraying the PLGA/tetraglycol solution into water. The size of PLGA nanospheres was manipulated by changing the concentration of PLGA/tetraglycol solution. Based on the hydrophobic interaction between PLGA and poly(propylene oxide) domain of F-127 (one of Pluronics, poly(ethylene oxide)-poly(propylene oxide)poly(ethylene oxide) triblock copolymer, F-127-coated PLGA nanospheres was prepared to enhance the stability of PLGA nanospheres in the aqueous media. For the application as a drug delivery vehicle, it was characterized by measuring the loading amount, the encapsulation efficiency and the release pattern of drug. Paclitaxel used as a potent anti-cancer drug was selected as a model drug.
Kim
B K
BK
Department of Polymer Science and Engineering, Hannam University, Daedeog Ku, Taejeon, Korea 306-791.
Kim
D
D
Cho
S H
SH
Yuk
S H
SH
D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D001673:Biodegradation, Environmental; D004337:Drug Carriers; D004339:Drug Compounding / Q000379:methods; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D019344:Lactic Acid; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures; D017239:Paclitaxel / Q000493:pharmacokinetics*; D011092:Polyethylene Glycols; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers
D000970:Antineoplastic Agents; D004337:Drug Carriers; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011092:Polyethylene Glycols; D017239:Paclitaxel