Human glutathion S-transferase A1 polymorphism and susceptibility to urothelial cancer in the Japanese population.
GSTA1 has been reported to be most efficient in detoxifying N-acetoxy PhIP. In this study, 341 Japanese urothelial cancer patients and 457 healthy controls were compared for frequencies of GSTA1 genotype. We present the first evidence of an association between GSTA1*B (-567G, -69T, -52A) and urothelial cancer among never smokers. The frequency of GSTA1 *A/*B or *B/*B genotype was 24.3% in urothelial cancer cases, compared with 21.2% in the control groups (OR=1.22; 95%CI 0.87-1.72) after adjustment for age, gender and smoking status. But among never smokers, the GSTA1 *A/*B or *B/*B genotype was significantly higher in urothelial cancer cases (31.2%) compared with the controls (19.9%) (OR=1.73; 95%CI 1.01-2.97). This study suggests that exposure to food-derived PhIP could be one of the risk factors in the incidence of urothelial cancer in never smokers.
Komiya
Yasuhiro
Y
Department of Public Health, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Miyazaki 889-1692, Japan.
Tsukino
Hiromasa
H
Nakao
Hiroyuki
H
Kuroda
Yoshiki
Y
Imai
Hirohisa
H
Katoh
Takahiko
T
D000368:Aged; D044466:Asian People; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014571:Urologic Neoplasms / Q000235:genetics*
D002352:Carrier Proteins; C484555:GSTA1 protein, human; D005982:Glutathione Transferase