[Stress-limiting properties of a new tetrahydropyrrolopyrazine derivative].
The effect of compound PV-174, selected from a series of tetrahydropyrrolopyrazine derivatives was studied on a model of immobilization stress in rats. Pretreatment with PV-174 decreases the stress-induced involution of thymus and spleen, hypertrophy of cpinephrosis, and gastric ulceration. The drug also blocks the stress-enhanced lipid peroxidation in lungs and myocardium, while not influencing the effect of kenalog (an exogenous glucocorticoid). It is suggested that one of the possible mechanisms of the antistressor effect of PV-174 is related to the drug action upon CNS.
Filippova
O V
OV
D000818:Animals; D007103:Immobilization; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D011719:Pyrazines / Q000008:administration & dosage*; D051381:Rats; D013315:Stress, Psychological / Q000188:drug therapy* / Q000378:metabolism
C502416:2-((2'-hydroxy-2'-phenoxymethyl)ethyl)-1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazine; D011719:Pyrazines