title: Recurrent torticollis secondary to Langerhans cell histiocytosis: a case report.
abstract: Torticollis is a common clinical sign encountered by pediatricians and orthopaedic surgeons in a wide spectrum of childhood conditions ranging from benign to life-threatening. We report the case of a child with recurrent torticollis caused by Langerhans Cell Histiocytosis (LCH). The patient was a 1-year-old boy with recurrent torticollis, followed by a painless swelling over the right temporal bone. The diagnosis was confirmed by an open biopsy of the calvarial lesion. As LCH is a very rare cause of torticollis it was not considered in the initial differential by the primary care physicians and the diagnosis was delayed about 4 months. The patient received chemotherapy with steroids and etoposide for 52 weeks. He showed complete regression of the sign and imaging tests at the end of treatment were normal. No relapse of symptoms occurred during a follow-up period of 2 years. The rarity of this disease as well as the site and form of presentation are emphasised to alert physicians for an early diagnostic evaluation, which is important to prevent neurological lesions and other late complications.
authors.affiliation: Haematology/Oncology Unit, 1st Department of Paediatrics/ University of Athens, "Aghia Sophia" Children's Hospital, Athens, Greece.
authors.forename: Stavroula
authors.initials: S
authors.lastname: Kostaridou
authors.forename: John
authors.initials: J
authors.lastname: Anastasopoulos
authors.forename: Charalambos
authors.initials: C
authors.lastname: Veliotis
authors.forename: John
authors.initials: J
authors.lastname: Nikas
authors.forename: Kalliopi
authors.initials: K
authors.lastname: Stefanaki
authors.forename: Fotini
authors.initials: F
authors.lastname: Tzortzatou-Stathopoulou
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007223:Infant; D008297:Male; D012008:Recurrence; D014103:Torticollis / Q000209:etiology*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide