title: Selenium level in benign and cancerous prostate.
abstract: The dietary microelement selenium (Se) has been proposed as a potential chemopreventive agent for prostate cancer. This element is present in various amounts in all tissues. Little information is available on Se level in patients with prostate gland disorders. The levels of Se in prostatic gland of patients with prostate cancer, benign prostate hyperplasia, and healthy controls were examined. The Se level for benign prostate hyperplasia (156 +/- 30.6 ng/g) was the same as in the control group (157 +/- 26.0 ng/g), but in the gland of prostate cancer patients (182 +/- 34.1 ng/g wet weight), the Se level was significantly (p < 0.01) higher than in both healthy controls and benign prostate hyperplasia. Thus, the Se level in human healthy controls is lower than in kidney and liver but higher compared with other tissues.
authors.affiliation: Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Lodz, Poland.
authors.forename: Bronislaw A
authors.initials: BA
authors.lastname: Zachara
authors.forename: Karolina
authors.initials: K
authors.lastname: Szewczyk-Golec
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Wolski
authors.forename: Janusz
authors.initials: J
authors.lastname: Tyloch
authors.forename: Zdzislaw
authors.initials: Z
authors.lastname: Skok
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Bloch-Boguslawska
authors.forename: Wojciech
authors.initials: W
authors.lastname: Wasowicz
mesh_terms: D000368:Aged; D004032:Diet; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000737:chemistry* / Q000473:pathology*; D011470:Prostatic Hyperplasia / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000737:chemistry*; D012643:Selenium / Q000032:analysis*
chemical_list: D012643:Selenium