title: Mechanistic classification of liver injury.
abstract: Toxic injury occurs in the liver more often than any other organ. This can be attributed to the fact that virtually all ingested substances that are absorbed are first presented to the liver and that the liver is responsible for the metabolism and elimination of many substances. Drug-induced liver injury has become a serious health problem in contemporary society. Moreover, liver toxicity is a significant impediment to development of new pharmaceuticals. A classification of liver injury is presented as a means to better understand the spectrum of known mechanisms of liver injury and to assist in discovering novel pathways of toxic liver injury.
authors.affiliation: College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA. john.cullen@ncsu.edu
authors.forename: John M
authors.initials: JM
authors.lastname: Cullen
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D015551:Autoimmunity / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D056487:Chemical and Drug Induced Liver Injury, Chronic / Q000145:classification* / Q000378:metabolism* / Q000473:pathology; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects*; D022781:Hepatocytes / Q000187:drug effects / Q000473:pathology; D006801:Humans; D008107:Liver Diseases / Q000145:classification* / Q000378:metabolism / Q000473:pathology; D008928:Mitochondria / Q000187:drug effects
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen; D003577:Cytochrome P-450 Enzyme System; D002118:Calcium