title: A comparison of the efficacy of heparinized and nonheparinized solutions for maintenance of perioperative radial arterial catheter patency and subsequent occlusion.
abstract: In a randomized, double-blind, controlled study, we compared heparinized and nonheparinized infusions for the maintenance of perioperative arterial catheter patency and the incidence of subsequent radial arterial occlusion. Two-hundred patients were randomized into 2 groups to receive heparinized (group H, n = 100) or nonheparinized (group S, n = 100) flush solutions. Radial and ulnar blood flows were assessed using Doppler probe and pulse oximetry before, just after, and 24 h after decannulation by the same investigator. The cannulation site was examined for complications such as hematoma, nerve injury, and infection. The mean duration of cannulations was 378 +/- 159.0 min in group H and 332 +/- 154.6 min in group S. The mean number of corrective interventions caused by dampening of the pressure wave (mean number of positional changes [group S, 1.5 +/- 2.0; group H, 1.4 +/- 3.8] and mean number of manual flushes [group S, 1.3 +/- 1.7; group H, 1.2 +/- 1.2]) was not significantly different in both groups. After decannulation, partial or total occlusion developed in 20 group H patients and 16 group S patients (not significant). The incidence of occlusion was correlated to the presence of hematoma at the puncture site after decannulation (P = 0.013), long duration of cannulation (P = 0.04), and age <65 yr (P = 0.009). In conclusion, there is no significant difference between heparinized and nonheparinized flush solutions for the maintenance of perioperative radial artery catheter patency.
authors.affiliation: Department of Anesthesiology and Reanimation, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Binnur E
authors.initials: BE
authors.lastname: Tuncali
authors.forename: Buhar
authors.initials: B
authors.lastname: Kuvaki
authors.forename: Bahattin
authors.initials: B
authors.lastname: Tuncali
authors.forename: Emine
authors.initials: E
authors.lastname: Capar
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use*; D001157:Arterial Occlusive Diseases / Q000150:complications; D002406:Catheterization, Peripheral / Q000379:methods*; D005260:Female; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D019990:Perioperative Care; D019999:Pharmaceutical Solutions / Q000008:administration & dosage / Q000627:therapeutic use*; D017534:Radial Artery / Q000502:physiology*; D012307:Risk Factors
chemical_list: D000925:Anticoagulants; D019999:Pharmaceutical Solutions; D006493:Heparin