Vasodilatation of the hindquarters induced by antagonism of GABA(A) receptors in the freely moving rat.
An intracisternal injection of the GABA(A) receptor antagonist bicuculline into conscious rats increased arterial pressure and decreased hindquarter resistance. Propranolol attenuated only the resistance response, but ganglionic block abolished both responses. These findings suggest that central GABA(A) receptor blockade induces an autonomic pressor action with hindquarter vasodilatation.
Takemoto
Yumi
Y
Department of Neurophysiology, Division of Integrated Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Minami-ku, Hiroshima, 734-8551 Japan. yumitake@hiroshima-u.ac.jp
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology*; D002714:Chlorisondamine / Q000494:pharmacology; D018756:GABA Antagonists / Q000494:pharmacology*; D005730:Ganglionic Blockers / Q000494:pharmacology; D006614:Hindlimb / Q000098:blood supply; D008297:Male; D009043:Motor Activity; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology; D014664:Vasodilation / Q000187:drug effects* / Q000502:physiology*; D014665:Vasodilator Agents / Q000494:pharmacology
D018756:GABA Antagonists; D005730:Ganglionic Blockers; D011963:Receptors, GABA-A; D014665:Vasodilator Agents; D011433:Propranolol; D002714:Chlorisondamine; D001640:Bicuculline