title: Breeding genetically modified rodents: tips for tracking and troubleshooting reproductive performance.
abstract: Infertility or reduced fertility in genetically modified mouse strains represents a serious bottleneck for planned research projects. The authors describe simple methods for troubleshooting poor reproductive performance in breeding colonies and introduce various means of assisted reproduction that might be used to 'rescue' infertile lines.
authors.affiliation: Charles River Laboratories, Transgenic Services, Wilmington, MA 01887, USA. kmurray@criver.com
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Murray
authors.forename: Nancy Jean
authors.initials: NJ
authors.lastname: Parker
mesh_terms: D000822:Animal Husbandry; D000818:Animals; D030801:Animals, Genetically Modified; D001947:Breeding / Q000379:methods*; D005260:Female; D007246:Infertility / Q000235:genetics*; D008297:Male; D051379:Mice; D012098:Reproduction / Q000235:genetics*; D027724:Reproductive Techniques, Assisted / Q000662:veterinary; D014730:Veterinary Medicine / Q000379:methods*