Influence of different calcium concentrations in the diet on bone metabolism in growing dairy goats and sheep.
The purpose of this study was to investigate, if different Ca concentrations in diets have an influence on bone mineral metabolism in growing goats and sheep. Twelve growing goats and sheep were divided into two groups. The two control groups received 6.1 g calcium/day (nG) and 6.7 g calcium/day (nS) for goat and sheep respectively. The other two groups were fed 17.7 g calcium/day (hG) and 18.5 g calcium/day (hS). Blood samples were taken 2, 4, 5 and 6 weeks after the start of the experiment. In serum Ca and vitamin D were determined and bone metabolism was measured using crosslinked carboxyterminal telopeptide of type I collagen (ICTP), crosslaps, bone-specific alkaline phosphatase and osteocalcin (OC). Bone mineral density (BMD) was quantified using quantitative computed tomography. Bone resorption marker (ICTP) concentrations were significantly different between both groups control sheep/control goat and hS/hG, but no significant differences were evident in the different feeding groups within one species. OC concentrations showed a similar course to ICTP. The goats had significantly higher concentrations compared with sheep. The 1,25 dihydroxyvitamin D (VITD) concentrations in both hCa groups were significantly lower than in the control groups. BMD increased in the hCa groups compared with the control groups with the time, but significant differences were only evident in sheep in week 2. The hCa diet did not induce differences between the groups within one species for all bone markers. The control Ca diet seems to improve the active Ca absorption via VITD whereas the hCa diet leads to a higher amount of Ca apparently digested. Higher BMD was only observed in group hS compared with nS.
Liesegang
A
A
Department of Veterinary Physiology and Animal Nutrition, Vetsuisse Faculty, Institute of Animal Nutrition, University of Zurich, 8057 Zurich, Switzerland. aliese@vetphys.unizh.ch
Risteli
J
J
D000469:Alkaline Phosphatase / Q000097:blood / Q000378:metabolism; D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000097:blood / Q000378:metabolism; D002136:Calcium, Dietary / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D003094:Collagen / Q000378:metabolism; D024042:Collagen Type I; D004305:Dose-Response Relationship, Drug; D005260:Female; D006041:Goats / Q000097:blood / Q000254:growth & development / Q000378:metabolism*; D009751:Nutritional Requirements; D015675:Osteocalcin / Q000378:metabolism; D010455:Peptides / Q000378:metabolism; D011897:Random Allocation; D012756:Sheep / Q000097:blood / Q000254:growth & development / Q000378:metabolism*; D014807:Vitamin D / Q000097:blood / Q000378:metabolism
D002136:Calcium, Dietary; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D014807:Vitamin D; D003094:Collagen; D000469:Alkaline Phosphatase; D002118:Calcium