Fluorescent dendrimers with a peptide cathepsin B cleavage site for drug delivery applications.
The synthesis of a multifunctionally equipped first generation (G1) dendrimer carrying a pentapeptide with a cathepsin[space]B cleavage site, chelating ligands for Pt2+-complexation, and a dansyl fluorescence marker is described and an investigation of its cellular uptake as well as intracellular localization by confocal fluorescence microscopy reported.
Fuchs
Sabine
S
Freie Universitat Berlin, Institut fur Chemie/Biochemie, Thielallee 63, D-14195 Berlin, Germany.
Otto
Henning
H
Jehle
Stefan
S
Henklein
Peter
P
Schluter
A Dieter
AD
D002401:Cathepsin B / Q000378:metabolism*; D050091:Dendrimers / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism*; D004337:Drug Carriers / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D005456:Fluorescent Dyes / Q000032:analysis / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D010446:Peptide Fragments / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism*
D050091:Dendrimers; D004337:Drug Carriers; D005456:Fluorescent Dyes; D010446:Peptide Fragments; D002401:Cathepsin B