title: Factors that influence the development of posterior capsule opacification with a polyacrylic intraocular lens.
abstract: OBJECTIVE
  To identify factors that contribute to posterior capsule opacification (PCO) after implantation of a 5.5 mm polyacrylic (IOL).
  
  
  METHODS
  A retrospective analysis of a cohort of sequential images taken from the PCO database at St. Thomas' Hospital, London, to include all patients with an AcrySof MA30 lens and a 1-year retroillumination image.
  
  
  METHODS
  Records of age, gender, axial length, and PCO measurements using the POCO software system were available. Images were divided into those with greater or less than 10% PCO. The degree of rhexis-IOL contact was recorded in clock hours.
  
  
  RESULTS
  Images of 60 eyes were analyzed. Twenty-one eyes had more than 10% PCO. No correlation was found between PCO and age, gender, or axial length. Forty-eight eyes (80%) had some loss of rhexis-IOL contact. These eyes had increased PCO (P < .001) compared with eyes with complete IOL-rhexis contact. More PCO developed when the rhexis was partly on and partly off the IOL.
  
  
  CONCLUSIONS
  PCO is reduced when the rhexis is in complete contact with the anterior IOL surface. The failure to achieve this accounts for the majority of increased PCO seen in patients implanted with this IOL model. PCO formation is related to surgical technique as well as IOL design, and comparisons cannot be made between IOLs without taking this into consideration. These results support the trend to the use of larger optic IOLs to prevent PCO and also support the "capsule compression" theory of PCO prevention.
authors.affiliation: Department of Ophthalmology, St. Thomas' Hospital, London, United Kingdom.
authors.forename: Siobhan M E
authors.initials: SM
authors.lastname: Wren
authors.forename: David J
authors.initials: DJ
authors.lastname: Spalton
authors.forename: Romina
authors.initials: R
authors.lastname: Jose
authors.forename: James
authors.initials: J
authors.lastname: Boyce
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Heatley
mesh_terms: D000180:Acrylic Resins; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002386:Cataract / Q000209:etiology*; D005260:Female; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000473:pathology*; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000180:Acrylic Resins