[Preventive effects of montelukast on the collagen expression of pulmonary arterioles in rats with chronic hypoxia].
OBJECTIVE
To evaluate the preventive effects of montelukast on the collagen expression of pulmonary arterioles in chronic hypoxic rats.


METHODS
Thirty male Wistar rats were randomly divided into three groups: control group, hypoxic group and montelukast preventive group. The animal model of pulmonary hypertension was established by exposing the rats to normabaric hypoxic conditions 8 hours q.d. for 3 weeks. The expression levels of collagen I and III in arterioles were observed by immunohistochemistry.


RESULTS
The positive degree of collagen I in pulmonary arterioles of hypoxic group was higher than that of control group (1.51+/-0.09 vs 1.15+/-0.05, P<0.01), and the positive degree of collagen I in pulmonary arterioles of preventive group (1.19+/-0.06) was lower than that of hypoxic group (P<0.01). The differences of positive degree of collagen III in pulmonary arterioles were not significant among the three groups (P>0.05).


CONCLUSIONS
Montelukast can reduce the hypoxia-induced deposition of collagen I in the pulmonary arterioles wall.
Chen
Xiao-ju
XJ
Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Cheng
De-yun
DY
Guan
Jian
J
Wang
Hui
H
Zhang
Yong
Y
Xia
Xiu-qiong
XQ
D000085:Acetates / Q000494:pharmacology*; D000818:Animals; D001160:Arterioles / Q000378:metabolism; D024042:Collagen Type I / Q000096:biosynthesis*; D003521:Cyclopropanes; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control; D000860:Hypoxia / Q000150:complications* / Q000378:metabolism; D020024:Leukotriene Antagonists / Q000494:pharmacology; D008297:Male; D011651:Pulmonary Artery / Q000378:metabolism*; D011804:Quinolines / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013440:Sulfides
D000085:Acetates; D024042:Collagen Type I; D003521:Cyclopropanes; D020024:Leukotriene Antagonists; D011804:Quinolines; D013440:Sulfides; C093875:montelukast