Mutations in the quinolone-resistance determining region (QRDR) of Salmonella strains isolated from pigs in Spain.
Quinolone-resistance determining region (QRDR) of Gyrase A gene was sequenced in 54 Salmonella strains of pig origin that have different quinolone-resistance patterns. Those strains accounted for 12 different serotypes. Mutations at Ser83 or Asp87 were predominant in the studied isolates. However, for serotypes Anatum and Virchow, resistance to quinolones seemed to be linked to specific mutations, namely, Ser83-->Tyr and Ser83-->Phe, respectively. Other mutations found in different positions did not seem to have clinical significance except for changes at Asp82.
Seminati
C
C
Departament de Sanitat i d'Anatomia Animals, Universitat Autònoma de Barcelona, Facultat de Veterinaria, 08193 Bellaterra, Barcelona, Spain. chiara.seminati@uab.es
Mejia
W
W
Mateu
E
E
Martin
M
M
D000818:Animals; D027081:DNA Gyrase / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics; D008826:Microbial Sensitivity Tests / Q000662:veterinary; D009154:Mutation / Q000235:genetics*; D015363:Quinolones / Q000494:pharmacology*; D012475:Salmonella / Q000187:drug effects* / Q000235:genetics*; D012481:Salmonella Infections, Animal / Q000188:drug therapy* / Q000382:microbiology; D012703:Serotyping / Q000662:veterinary; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy* / Q000382:microbiology
D015363:Quinolones; D027081:DNA Gyrase