title: Effect of chronic administration of lignan complex isolated from flaxseed on the hemopoietic system.
abstract: Lignan complex has been isolated from flaxseed. It has been shown to reduce serum lipids and the extent of hypercholesterolemic atherosclerosis. However, it is not known whether the chronic use of lignan complex has any adverse effects on the hemopoietic system. The effects of lignan complex (40 mg/kg body wt orally daily for 2 months) on the red blood cells (RBC) count, mean corpuscular volume (MCV), red cell distribution width (RDW), hematocrit (Hct), hemoglobin (Hb), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and counts of white blood cell (WBC), granulocytes, lymphocytes, monocytes and platelet, and platelet volume were investigated in normo- and hypercholesterolemic rabbits. The results show that lignan complex had no adverse effects of counts of RBC, WBC, granulocytes, lymphocytes, monocytes and platelet in both the normo- and hyper-cholesterolemic rabbits. The values for MCV, RDW, Hct, Hb, MCH, MCHC, and platelet volume were similar in lignan complex-treated or untreated normo- and hypercholesterolemic rabbits. It is concluded that chronic use of lignan complex had no adverse effects on the hemopoietic system.
authors.affiliation: Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Canada. prasadk@usask.ca
authors.forename: Kailash
authors.initials: K
authors.lastname: Prasad
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001792:Blood Platelets / Q000378:metabolism; D002072:Butylene Glycols / Q000494:pharmacology; D002784:Cholesterol / Q000378:metabolism; D004909:Erythrocyte Indices; D004912:Erythrocytes / Q000166:cytology; D005260:Female; D019597:Flax / Q000378:metabolism*; D006098:Granulocytes / Q000378:metabolism; D006400:Hematocrit; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000187:drug effects*; D006454:Hemoglobins / Q000378:metabolism; D007962:Leukocytes / Q000166:cytology; D017705:Lignans / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology; D050356:Lipid Metabolism; D008214:Lymphocytes / Q000378:metabolism; D009000:Monocytes / Q000378:metabolism; D010976:Platelet Count; D011817:Rabbits; D013997:Time Factors
chemical_list: D002072:Butylene Glycols; D006454:Hemoglobins; D017705:Lignans; D002784:Cholesterol; C060283:secoisolariciresinol