Immobilization of ibuprofen and copper-ibuprofen drugs on layered double hydroxides.
The immobilization of the NSAID ibuprofen (Hibp) and the Cu(II)-ibp compound on magnesium-aluminum layered double hydroxides (Mg3Al-LDH) is described. Ibuprofen was intercalated on LDHs by three routes (ion exchange, co-precipitation, and reconstruction). The organic drug and the Cu(II)-ibp were also immobilized by adsorption on LDH external surfaces. Materials were characterized by elemental analysis, UV/VIS, FTIR, and Raman spectroscopies, powder X-ray diffractometry (XRD), thermogravimetry, and electronic paramagnetic resonance (EPR). Mg3Al-(ibp)(cop) (30% w/w of drug/material) and Mg3Al-(ibp)(ie) (33%) materials exhibit bilayer arrangements of ibp anions intercalated between the host layers. Mg3Al-(ibp)(rec) and Mg3Al-(ibp)(ads) contain 13% and 6.2% of ibuprofenate, respectively. Mg3Al-(Cu-ibp)(ads) exhibits two Cu centers in different environments interacting with host layers. Pharmacological potential of materials are compared considering the amounts of immobilized drugs and their buffering properties. Mg3Al-(ibp)(ie) and Mg3Al-(ibp)(cop) exhibit poor buffering property, but contain high ibp amounts. Mg3Al-(ibp)(ads) despite having buffering property, contains low amount of ibuprofen. Mg3Al-(ibp)(rec) combines significant amount of immobilized ibp with good buffering property. Mg3Al-(Cu-ibp)(ads), due to the buffering property, may be an interesting new formulation aiming to decrease gastric irritation.
Gordijo
Cláudia R
CR
Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, CP 26077, CEP 05513-900, São Paulo, SP, Brazil.
Barbosa
César A S
CA
Da Costa Ferreira
Ana M
AM
Constantino
Vera R L
VR
de Oliveira Silva
Denise
D
D000327:Adsorption; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002021:Buffers; D002138:Calibration; D002254:Carbonates / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D004339:Drug Compounding; D004578:Electron Spin Resonance Spectroscopy; D006878:Hydroxides / Q000737:chemistry; D007052:Ibuprofen / Q000737:chemistry*; D007364:Intercalating Agents; D007474:Ion Exchange; D008274:Magnesium / Q000737:chemistry; D008958:Models, Molecular; D009566:Nitrates / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D013818:Thermogravimetry; D014961:X-Ray Diffraction
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002021:Buffers; D002254:Carbonates; D006878:Hydroxides; D007364:Intercalating Agents; D009566:Nitrates; D003300:Copper; D008274:Magnesium; D007052:Ibuprofen