Bioactive asterosaponins from the starfish Culcita novaeguineae.
Two new sulfated steroidal pentaglycosides (asterosaponins), novaeguinosides I (2) and II (3), along with the known regularoside B (1) were isolated from the starfish Culcita novaeguineae. Their structures were elucidated by extensive NMR techniques as well as chemical evidence. The new asterosaponins showed marginal in vitro cytotoxicity against two human tumor cell lines.
Tang
Hai-Feng
HF
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, Shanghai 200433, People's Republic of China. tanghaifeng71@126.com
Yi
Yang-Hua
YH
Li
Ling
L
Sun
Peng
P
Zhang
San-Qi
SQ
Zhao
Yue-Ping
YP
D000818:Animals; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013215:Starfish / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D012503:Saponins; C499565:novaeguinoside I; C499567:novaeguinoside II; C499568:regularoside B