title: Tooth development included in the multifocal jaw lesions of Langerhans cell histiocytosis.
abstract: Many cases demonstrating the oral manifestations of Langerhans cell histiocytosis (LCH) have been reported; however, tooth development in jaw lesions has rarely been mentioned. This paper reports the case of a 3-year-old Japanese girl with LCH suffering from multiple osteolytic lesions of the skull and jaw bones. She was referred to our paediatric clinic because of swelling of the mucogingival folds in the upper and lower primary molar regions. The patient responded well to steroid therapy and the osteolytic lesions resolved. There was an accompanying development of permanent tooth germs included in the lesions. Langerhans cell histiocytosis in children usually has a long-term clinical course and paediatric dentists should be involved with oral health care for affected patients.
authors.affiliation: Division of Pediatric Dentistry, Department of Oral Health Science, Course for Oral Life Science, Niigata University Graduate School of Medical and Dental Sciences, Gakkocho-dori, Niigata, Japan. mitomi@dent.niigata-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Mitomi
authors.forename: M
authors.initials: M
authors.lastname: Tomizawa
authors.forename: T
authors.initials: T
authors.lastname: Noda
mesh_terms: D001641:Bicuspid / Q000503:physiopathology; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006646:Histiocytosis, Langerhans-Cell / Q000503:physiopathology*; D006801:Humans; D008336:Mandibular Diseases / Q000503:physiopathology*; D008439:Maxillary Diseases / Q000503:physiopathology*; D008963:Molar / Q000503:physiopathology; D009805:Odontogenesis / Q000502:physiology*; D010014:Osteolysis / Q000503:physiopathology; D014083:Tooth Germ / Q000503:physiopathology