[On the significance of RNA in human sperm].
Our understanding of the molecular complexities of human spermatozoa continues to be rather rudimentary. This includes the unique packaging and structure of the sperm genome along with its paternally derived RNAs in preparation for their delivery to the egg. Both highlight the inadequacy in our understanding of how these genetic factors contribute to a healthy child. As a means to address this deficiency it was recently shown that human spermatozoal RNA isolated from the ejaculate can be used to transcriptionally profile the male gamete. It is fully expected that a genetic fingerprint characteristic of the normal fertile spermatozoon can be identified and that deviations from this profile can be detected.
Krawetz
Stephen A
SA
Department of Obstetrics and Gynecology, Center for Molecular Medicine and Genetics, Institute for Scientific Computing, Wayne State University School of Medicine, 275 E. Hancock, Detroit, MI 48201, USA. steve@compbio.med.wayne.edu
D020224:Expressed Sequence Tags; D006801:Humans; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D012313:RNA / Q000235:genetics* / Q000302:isolation & purification; D013094:Spermatozoa / Q000737:chemistry / Q000502:physiology*; D014158:Transcription, Genetic
D012313:RNA