title: On the origin of the DNA sequence selectivity of the azinomycins.
abstract: Simplified synthetic azinomycins preferentially induce in vitro DNA interstrand cross-links at the same 5'-d(GCC)-3' site as the natural products revealing that non-covalent interactions are relatively unimportant in defining sequence specificity.
authors.affiliation: Department of Chemistry, University of Warwick, Coventry, UK CV4 7AL.
authors.forename: Rachel C
authors.initials: RC
authors.lastname: LePla
authors.forename: Cyrille A S
authors.initials: CA
authors.lastname: Landreau
authors.forename: Michael
authors.initials: M
authors.lastname: Shipman
authors.forename: George D D
authors.initials: GD
authors.lastname: Jones
mesh_terms: D053961:Azabicyclo Compounds; D001388:Aziridines / Q000737:chemistry* / Q000494:pharmacology; D004247:DNA / Q000737:chemistry*; D004151:Dipeptides; D004852:Epoxy Compounds / Q000737:chemistry* / Q000494:pharmacology; D006020:Glycopeptides / Q000737:chemistry / Q000494:pharmacology; D036341:Intercellular Signaling Peptides and Proteins; D009281:Naphthalenes / Q000737:chemistry / Q000494:pharmacology; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
chemical_list: D053961:Azabicyclo Compounds; D001388:Aziridines; D004151:Dipeptides; D004852:Epoxy Compounds; D006020:Glycopeptides; D036341:Intercellular Signaling Peptides and Proteins; D009281:Naphthalenes; D010455:Peptides; C051055:azinomycin B; C051054:azinomycin A; D004247:DNA