Antitubercular agents. Part 1: synthesis of phthalimido- and naphthalimido-linked phenazines as new prototype antitubercular agents.
The preparation and antitubercular properties of a series of phthalimido- and naphthalimido-linked phenazines are described. Some of these new compounds inhibited the growth of Mycobacterium tuberculosis ATCC 27294, Mycobacterium avium ATCC 49601, Mycobacterium intracellulare ATCC 13950 and some clinical isolates.
Kamal
Ahmed
A
Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Hyderabad 500007, India. ahmedkamal@iict.res.in
Hari Babu
A
A
Venkata Ramana
A
A
Sinha
Rakesh
R
Yadav
J S
JS
Arora
Sudarshan K
SK
D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007094:Imides / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009162:Mycobacterium avium / Q000187:drug effects; D015269:Mycobacterium avium Complex / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009281:Naphthalenes / Q000737:chemistry*; D010619:Phenazines / Q000138:chemical synthesis* / Q000494:pharmacology; D010797:Phthalimides / Q000737:chemistry; D013329:Structure-Activity Relationship
D000995:Antitubercular Agents; D007094:Imides; D009281:Naphthalenes; D010619:Phenazines; D010797:Phthalimides