Experimental therapeutic intervention with ascorbic acid in ethanol induced testicular injuries in rats.
Ascorbic acid treatment significantly increased the activities of testicular delta5, 3beta-HSD and 17beta-HSD. Moreover, the treatment was also associated with significant decrease in oxidative stress in the testis. Ethanol induced oxidative stress and decreased steroidogenesis can be reversed by treatment with ascorbic acid.
Maneesh
M
M
Department of Biochemistry, Sikkim Manipal Institute of Medicine Sciences, Gangtok, India.
Jayalakshmi
H
H
Dutta
Sanjiba
S
Chakrabarti
Amit
A
Vasudevan
D M
DM
D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D000431:Ethanol / Q000633:toxicity*; D005978:Glutathione / Q000378:metabolism; D012739:Gonadal Steroid Hormones / Q000096:biosynthesis; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D013737:Testis / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism
D000975:Antioxidants; D012739:Gonadal Steroid Hormones; D008054:Lipid Peroxides; D000431:Ethanol; D005978:Glutathione; D001205:Ascorbic Acid