title: The role of QSAR in dopamine interactions.
abstract: Dopamine receptor blockers have been used for the treatment of schizophrenia for many years. We have developed 22 quantitative structure activity relationships (QSAR) for different sets of compounds to understand chemical-biological interactions governing their activities toward dopamine receptors.
authors.affiliation: Department of Chemistry, Pomona College, Claremont, CA 91711, USA. atessier@pomona.edu <atessier@pomona.edu>
authors.forename: Corwin
authors.initials: C
authors.lastname: Hansch
authors.forename: Rajeshwar P
authors.initials: RP
authors.lastname: Verma
authors.forename: Alka
authors.initials: A
authors.lastname: Kurup
authors.forename: Suresh B
authors.initials: SB
authors.lastname: Mekapati
mesh_terms: D015259:Dopamine Agents / Q000737:chemistry* / Q000378:metabolism*; D018492:Dopamine Antagonists / Q000378:metabolism / Q000494:pharmacology; D065127:Dopamine D2 Receptor Antagonists; D006220:Haloperidol / Q000031:analogs & derivatives / Q000378:metabolism; D006801:Humans; D011485:Protein Binding / Q000502:physiology; D021281:Quantitative Structure-Activity Relationship; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D050638:Receptors, Dopamine D4
chemical_list: C493599:DRD4 protein, human; D015259:Dopamine Agents; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D017448:Receptors, Dopamine D2; D050638:Receptors, Dopamine D4; D006220:Haloperidol