[A case of catatonia associated with the ingestion of hydroxyzine].
A twenty-six-year male who presented with a consciousness disturbance induced by the ingestion of an estimated 7g of hydroxyzine. He demonstrated bipolar symptoms which consisted of both stupor and excitement, and both an increase in muscle tension and apnea, however, these symptoms improved after the infusion of diazepam. He was diagnosed to demonstrate catatonia. After treatment composing three days of mechanical ventilation in combination with the administration of sedatives and muscle relaxatants, his symptoms improved. Hydroxyzine is thus considered to be able to induce catatonia and this mechanism of this condition is discussed.
Yanagawa
Youichi
Y
Department of Traumatology and Critical Care Medicine, National Defense Medical College (NDMC), 3-2 Namiki, Tokorozawa-shi, Saitama 359-8513, Japan.
Ohshita
Takashi
T
Takemoto
Masaaki
M
Matsumoto
Naoto
N
Sakamoto
Toshihisa
T
Okada
Yoshiaki
Y
D000328:Adult; D001714:Bipolar Disorder / Q000139:chemically induced; D002389:Catatonia / Q000139:chemically induced* / Q000523:psychology; D006634:Histamine H1 Antagonists / Q000009:adverse effects*; D006801:Humans; D006919:Hydroxyzine / Q000009:adverse effects*; D008297:Male; D013406:Suicide, Attempted
D006634:Histamine H1 Antagonists; D006919:Hydroxyzine