title: Validating affective temperaments in their subaffective and socially positive attributes: psychometric, clinical and familial data from a French national study.
abstract: BACKGROUND
  One of the major objectives of the French National EPIDEP Study was to show the feasibility of systematic assessment of bipolar II (BP-II) disorder and beyond. In this report we focus on the utility of the affective temperament scales (ATS) in delineating this spectrum in its clinical as well as socially desirable expressions.
  
  
  METHODS
  Forty-two psychiatrists working in 15 sites in four regions of France made semi-structured diagnoses based on DSM IV criteria in a sample of 452 consecutive major depressive episode (MDE) patients (from which bipolar I had been removed). At least 1 month after entry into the study (when the acute depressive phase had abated), they assessed affective temperaments by using a French version of the precursor of the Temperament Evaluation of Memphis, Pisa, Paris and San Diego (TEMPS). Principal component analyses (PCA) were conducted on hyperthymic (HYP-T), depressive (DEP-T) and cyclothymic (CYC-T) temperament subscales as assessed by clinicians, and on a self-rated cyclothymic temperament (CYC-TSR). Scores on each of the temperament subscales were compared in unipolar (UP) major depressive disorder versus BP-II patients, and in the entire sample subdivided on the basis of family history of bipolarity.
  
  
  RESULTS
  PCAs showed the presence of a global major factor for each clinician-rated subscale with respective eigenvalues of the correlation matrices as follows: 7.1 for HYP-T, 6.0 for DEP-T, and 4.7 for CYC-T. Likewise, on the self-rated CYC-TSR, the PCA revealed one global factor (with an eigenvalue of 6.6). Each of these factors represented a melange of both affect-laden and adaptive traits. The scores obtained on clinician and self-ratings of CYC-T were highly correlated (r=0.71). The scores of HYP-T and CYC-T were significantly higher in the BP-II group, and DEP-T in the UP group (P<0.001). Finally, CYC-T scores were significantly higher in patients with a family history of bipolarity.
  
  
  CONCLUSIONS
  These data uphold the validity of the affective temperaments under investigation in terms of face, construct, clinical and family history validity. Despite uniformity of depressive severity at entry into the EPIDEP study, significant differences on ATS assessment were observed between UP and BP-II patients in this large national cohort. Self-rating of cyclothymia proved reliable. Adding the affective temperaments-in particular, the cyclothymic-to conventional assessment methods of depression, a more enriched portrait of mood disorders emerges. More provocatively, our data reveal socially positive traits in clinically recovering patients with mood disorders.
authors.affiliation: International Mood Center, VA Psychiatry Service, VA Hospital, University of California at San Diego, 3350 La Jolla Village Dr. (116-A), San Diego, CA 92161, USA. hakiskal@ucsd.edu
authors.forename: Hagop S
authors.initials: HS
authors.lastname: Akiskal
authors.forename: K
authors.initials: K
authors.lastname: Akiskal
authors.forename: J-F
authors.initials: JF
authors.lastname: Allilaire
authors.forename: J-M
authors.initials: JM
authors.lastname: Azorin
authors.forename: M L
authors.initials: ML
authors.lastname: Bourgeois
authors.forename: D
authors.initials: D
authors.lastname: Sechter
authors.forename: J-P
authors.initials: JP
authors.lastname: Fraud
authors.forename: L
authors.initials: L
authors.lastname: Chatenêt-Duchêne
authors.forename: S
authors.initials: S
authors.lastname: Lancrenon
authors.forename: G
authors.initials: G
authors.lastname: Perugi
authors.forename: E G
authors.initials: EG
authors.lastname: Hantouche
mesh_terms: D000328:Adult; D000342:Affective Symptoms / Q000175:diagnosis / Q000235:genetics / Q000523:psychology*; D001714:Bipolar Disorder / Q000175:diagnosis / Q000235:genetics / Q000523:psychology*; D003431:Cross-Cultural Comparison; D003527:Cyclothymic Disorder / Q000175:diagnosis / Q000523:psychology; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000235:genetics / Q000523:psychology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005240:Feasibility Studies; D005260:Female; D005602:France; D006801:Humans; D007802:Language; D008297:Male; D010552:Personality Assessment / Q000706:statistics & numerical data; D010555:Personality Inventory / Q000706:statistics & numerical data*; D010641:Phenotype; D011594:Psychometrics / Q000706:statistics & numerical data; D015203:Reproducibility of Results; D012919:Social Behavior; D013694:Temperament / Q000145:classification