title: Subclinical alveolar involvement in ulcerative colitis.
abstract: BACKGROUND
  Although pulmonary dysfunction has been described in patients with ulcerative colitis (UC), the pathogenesis remains unclear. Our aim was to study alveolar epithelial damage using technetium-99m diethylene triamine penta acetic acid (Tc-99m DTPA) aerosol scintigraphy in patients with UC but without respiratory symptoms.
  
  
  METHODS
  We enrolled 32 patients (18 women and 14 men; mean age, 36.4 +/- 11.6 yr) with active UC, 10 patients with inactive UC (6 women and 4 men; mean age, 43.4 +/- 11.8 yr), and 31 healthy controls (24 women and 7 men; mean age, 40 +/- 10 yr). Tc-99m DTPA aerosol scintigraphy was performed on all patients and controls. The relationship between alveolar epithelial permeability and the activity, localization, and duration of the disease was studied.
  
  
  RESULTS
  There was a significant difference between alveolar epithelial permeability results in patients with active UC and those of the controls (P < 0.001). The same correlation was also found between the patients with inactive UC and the control group (P < 0.001). There was no correlation between Tc-99m DTPA alveolar scintigraphic test results and the stage of activity, localization, and duration of the disease.
  
  
  CONCLUSIONS
  A latent pulmonary involvement may exist in patients with active and inactive UC. The alveolar involvement may be the earliest pulmonary damage, and a DTPA clearance test may show the early changes in pulmonary epithelial permeability that precedes clinical symptoms. Increased alveolar epithelial permeability is an extraintestinal manifestation in patients with UC and is not related to the activity of the colitis.
authors.affiliation: Department of Gastroenterology, Erciyes University School of Medicine, Kayseri, Turkey. sgursoy@erciyes.edu.tr
authors.forename: Sebnem
authors.initials: S
authors.lastname: Gursoy
authors.forename: Kadri
authors.initials: K
authors.lastname: Guven
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kula
authors.forename: Ozlem
authors.initials: O
authors.lastname: Canoz
authors.forename: Alper
authors.initials: A
authors.lastname: Yurci
authors.forename: Kursad
authors.initials: K
authors.lastname: Unluhizarci
authors.forename: Omer
authors.initials: O
authors.lastname: Ozbakir
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yucesoy
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000336:Aerosols; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010539:Permeability; D011650:Pulmonary Alveoli / Q000000981:diagnostic imaging* / Q000378:metabolism*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000493:pharmacokinetics*; D020545:Respiratory Mucosa / Q000000981:diagnostic imaging* / Q000378:metabolism*; D012720:Severity of Illness Index; D016284:Technetium Tc 99m Pentetate / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D000336:Aerosols; D019275:Radiopharmaceuticals; D016284:Technetium Tc 99m Pentetate