Genetic factors in neuromuscular pain.
Recent evidence suggests that fibromyalgia, a chronic widespread pain condition and related syndromes (chronic fatigue syndrome, irritable bowel syndrome, etc.) may share heritable pathophysiologic features. We review the recent literature on genetic and familial factors found to participate in the pathogenesis of these syndromes, specifically fibromyalgia, including evidence suggesting that serotonin- and dopamine-related genes may play a role in the pathogenesis of these illnesses. The importance of environmental factors triggering these conditions in predisposed individuals is also discussed.
Buskila
Dan
D
Department of Internal Medicine, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84101, Israel. dbuskila@bgumail.bgu.ac.il
Neumann
Lily
L
Press
Joseph
J
D004298:Dopamine / Q000235:genetics; D004777:Environment; D005356:Fibromyalgia / Q000235:genetics* / Q000503:physiopathology*; D005819:Genetic Markers; D006801:Humans; D012701:Serotonin / Q000235:genetics
D005819:Genetic Markers; D012701:Serotonin; D004298:Dopamine