Nonopsonic phagocytosis of erythrocytes infected with ring-stage Plasmodium falciparum.
Ring-stage parasitized erythrocytes (RPEs) were demonstrated to interact with effector cells of the innate immune system. With receptor blockade studies and CD36-null macrophages, human and murine macrophages were shown to phagocytose RPEs through the pattern recognition receptor CD36. These in vitro data implicate scavenger receptors in the clearance of RPEs.
Ayi
Kodjo
K
Department of Medicine, University of Toronto, Ontario, Canada.
Patel
Samir N
SN
Serghides
Lena
L
Smith
Todd G
TG
Kain
Kevin C
KC
D000818:Animals; D018955:CD36 Antigens / Q000502:physiology*; D004912:Erythrocytes / Q000469:parasitology*; D006801:Humans; D007113:Immunity, Innate; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010587:Phagocytosis; D010963:Plasmodium falciparum / Q000276:immunology*; D015800:Protozoan Proteins / Q000502:physiology
D018955:CD36 Antigens; D015800:Protozoan Proteins; C085731:erythrocyte membrane protein 1, Plasmodium falciparum