title: Photo-isomerization of fluvoxamine in aqueous solutions.
abstract: The hydrolysis and photolysis of fluvoxamine, a selective serotonin reuptake inhibitor, in aqueous buffer solutions (pH 5, 7, and 9), in synthetic humic water, and lake waters were investigated in the dark and in a growth chamber outfitted with fluorescent lamps simulating the UV output of sunlight at 25 degrees C. No significant hydrolytic degradation/isomerization was observed for 30 days in all aqueous solutions. However, fluvoxamine was moderately isomerized to its (Z)-isomer by simulated sunlight. The photo-isomerization occurred in two stages. The photo-isomerization occurred rapidly within the first 7 days and slowly thereafter with a rate constant of 0.12-0.19 day(-1) for the first stage and 0.04-0.05 day(-1) for the second stage. Photosensitized rate constants in synthetic humic water and in lake waters were approximately 6-7 times faster than that in pH 9 buffer with the rate constants of 1.15-1.34 day(-1) in the first stage. The (Z)-isomer of fluvoxamine was the only product detected in all aqueous solutions and was identified using LC-ESI-MS.
authors.affiliation: Mississippi State Chemical Laboratory, Mississippi State University, PO Box CR, Mississippi State, MS 39762, USA.
authors.forename: Jeong-Wook
authors.initials: JW
authors.lastname: Kwon
authors.forename: Kevin L
authors.initials: KL
authors.lastname: Armbrust
mesh_terms: D000465:Algorithms; D018687:Antidepressive Agents, Second-Generation / Q000032:analysis*; D016666:Fluvoxamine / Q000032:analysis*; D006868:Hydrolysis; D007536:Isomerism; D007700:Kinetics; D010782:Photolysis; D012722:Sewage / Q000032:analysis; D012996:Solutions; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D014867:Water; D014874:Water Pollutants, Chemical / Q000032:analysis
chemical_list: D018687:Antidepressive Agents, Second-Generation; D012722:Sewage; D012996:Solutions; D014874:Water Pollutants, Chemical; D014867:Water; D016666:Fluvoxamine