title: Distinct cytokine release profiles from human endothelial and THP-1 macrophage-like cells exposed to different amphotericin B formulations.
abstract: Amphotericin B(AmB) formulations, Fungizone, and Amphotec caused substantially greater proinflammatory cytokine release than AmBisome (L-AMB) and Abelcet in TPA differentiated THP-1 macrophages as determined by antibody based protein arrays. Lipopolysaccharide but not AmB induced significant pro-inflammatory cytokines in human endothelial cells.
authors.affiliation: Department of Biology, University of Wisconsin-Eau Claire, Eau Claire, WI 54702, USA. Turtinen@uwec.edu
authors.forename: Lloyd W
authors.initials: LW
authors.lastname: Turtinen
authors.forename: Lindsay A
authors.initials: LA
authors.lastname: Bremer
authors.forename: David N
authors.initials: DN
authors.lastname: Prall
authors.forename: Jenifer
authors.initials: J
authors.lastname: Schwartzhoff
authors.forename: Scott C
authors.initials: SC
authors.lastname: Hartsel
mesh_terms: D000666:Amphotericin B / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D002626:Chemistry, Pharmaceutical; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism
chemical_list: D016207:Cytokines; D000666:Amphotericin B