A plethora of interacting organellar Ca2+ stores.
The endoplasmic reticulum is not the only major agonist-releasable Ca2+ store within cells; it is now clear that virtually all organelles so far studied have the ability to act as mobilizable Ca2+ stores. From recent findings with regard to Ca2+ transportation and Ca2+ homeostasis within a variety of cell organelles such as the mitochondria, nucleus, Golgi and lysosomes, it emerges that many of these organellar Ca2+ stores appear to interact with each other, adding a further level of complexity to Ca2+ signalling events.
Michelangeli
Francesco
F
School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. F.michelangeli@Bham.ac.uk
Ogunbayo
Oluseye A
OA
Wootton
Laura L
LL
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D020013:Calcium Signaling / Q000502:physiology*; D002352:Carrier Proteins / Q000378:metabolism; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism*; D016623:Ion Pumps / Q000378:metabolism; D009685:Nuclear Envelope / Q000378:metabolism; D015388:Organelles / Q000378:metabolism*
D015220:Calcium Channels; D002352:Carrier Proteins; D016623:Ion Pumps; D002118:Calcium