title: Effect of bread containing resistant starch on postprandial blood glucose levels in humans.
abstract: We examined the inhibitory effect of a single ingestion of bread containing resistant starch (bread containing about 6 g of resistant starch derived from tapioca per 2 slices) (test food) on the postprandial increase in blood glucose in male and female adults with a fasting blood glucose level between 100 and 140 mg/dl. Bread not containing resistant starch (placebo) was used as the control. The study was conducted in 20 subjects (9 men and 11 women with a mean age of 50.5+/-7.5 years) using the crossover method, with a single ingestion of either bread containing resistant starch or the placebo. Blood glucose and insulin were measured before ingestion, and at 0.5, 1, 1.5, and 2 h after ingestion. The blood glucose level before ingestion was stratified into a borderline group (blood glucose level >/= 111 mg/dl) and a normal group (blood glucose level </= 110 mg/dl), with the upper limit of the normal range defined as 110 mg/dl. Postprandial increases in both blood glucose and blood insulin were significantly inhibited in subjects in the borderline group who took the test food in comparison with the placebo group (blood glucose: p<0.05 and p<0.01 at 1 and 1.5 h after ingestion respectively; insulin: p<0.05, p<0.01 and p<0.05 at 1, 1.5, and 2 h after ingestion respectively). These results indicate that bread containing resistant starch is useful for prevention of lifestyle-related diseases such as diabetes mellitus, and as a supplementary means of dietetic therapy.
authors.affiliation: Central Institute, Yamazaki Baking Co., Ltd., Tokyo, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Yamada
authors.forename: Seio
authors.initials: S
authors.lastname: Hosoya
authors.forename: Shigeru
authors.initials: S
authors.lastname: Nishimura
authors.forename: Takashi
authors.initials: T
authors.lastname: Tanaka
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Kajimoto
authors.forename: Akira
authors.initials: A
authors.lastname: Nishimura
authors.forename: Osami
authors.initials: O
authors.lastname: Kajimoto
mesh_terms: D000328:Adult; D000886:Anthropometry; D001786:Blood Glucose / Q000032:analysis*; D001794:Blood Pressure; D001939:Bread / Q000032:analysis*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D010919:Placebos; D019518:Postprandial Period; D013213:Starch
chemical_list: D001786:Blood Glucose; D007328:Insulin; D010919:Placebos; D013213:Starch