Rapid viral load suppression following generic highly active antiretroviral therapy in Southern Indian HIV-infected patients.
We prospectively studied the initial results of 6 months of generic efavirenz-based therapy on the plasma viral load in 40 patients at YRG Centre for AIDS Research and Education, a tertiary HIV referral centre in southern India. The median baseline plasma viral load was 259,000 copies/ml and at 6 months 95% of patients had plasma viral loads less than 400 copies/ml. The data support the use of generic non-nucleoside reverse transcriptase inhibitor-based regimens in resource-limited settings.
Kumarasamy
Nagalingeswaran
N
YRG Centre for AIDS Research and Education, VHS, Chennai, India.
Vallabhaneni
Snigdha
S
Flanigan
Timothy P
TP
Balakrishnan
Pachamuthu
P
Cecelia
Anitha
A
Carpenter
Charles C J
CC
Solomon
Suniti
S
Mayer
Kenneth H
KH
D000328:Adult; D000480:Alkynes; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D023241:Antiretroviral Therapy, Highly Active; D048588:Benzoxazines; D003521:Cyclopropanes; D016568:Drugs, Generic; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1; D006801:Humans; D007194:India; D019259:Lamivudine / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010078:Oxazines / Q000008:administration & dosage*; D011446:Prospective Studies; D013607:Tablets; D016896:Treatment Outcome; D019562:Viral Load; D015215:Zidovudine / Q000008:administration & dosage*
D000480:Alkynes; D019380:Anti-HIV Agents; D048588:Benzoxazines; D003521:Cyclopropanes; D016568:Drugs, Generic; D010078:Oxazines; D013607:Tablets; D019259:Lamivudine; D015215:Zidovudine; C098320:efavirenz