title: (SR/RS)-cyclohexanyl PNAs: conformationally preorganized PNA analogues with unprecedented preference for duplex formation with RNA.
abstract: PNA oligomers H-GTAGATCAT-lys-NH2 with cis-(1S,2R/1R,2S)-cyclohexyl-T (III) in the backbone form PNA:RNA duplexes with Tm approximately 30-50 degrees C higher than that of PNA:DNA duplexes. In comparison, cis-(1S,2R/1R,2S)-cyclopentyl PNA-T (IV) form highly stable duplexes with both RNA and DNA without discrimination.
authors.affiliation: Organic Chemistry Division (Synthesis), National Chemical Laboratory, Pune 411008, India.
authors.forename: T
authors.initials: T
authors.lastname: Govindaraju
authors.forename: Vaijayanti A
authors.initials: VA
authors.lastname: Kumar
authors.forename: Krishna N
authors.initials: KN
authors.lastname: Ganesh
mesh_terms: D002942:Circular Dichroism; D003510:Cyclohexanes / Q000737:chemistry* / Q000378:metabolism; D009690:Nucleic Acid Conformation; D009693:Nucleic Acid Hybridization; D020135:Peptide Nucleic Acids / Q000737:chemistry* / Q000378:metabolism; D012313:RNA / Q000737:chemistry* / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D003510:Cyclohexanes; D020135:Peptide Nucleic Acids; D012313:RNA