title: Lathyranoic acid A: first secolathyrane diterpenoid in nature from Euphorbia lathyris.
abstract: [structures: see text] Lathyranoic acid A (1), the first secolathyrane diterpenoid with an unprecedented skeleton, and a new diterpenoid Euphorbia factor L11 (2) were isolated from the seeds of Euphorbia lathyris. Their structures were elucidated by spectroscopic analysis and chemical methods. A biogenetic route involving an enzymatic Baeyer-Villiger oxidation as the key step was postulated for the transformation of 2 to 1 and mimicked by an unusual chemical Baeyer-Villiger oxidation.
authors.affiliation: State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, P R China.
authors.forename: Shang-Gao
authors.initials: SG
authors.lastname: Liao
authors.forename: Zha-Jun
authors.initials: ZJ
authors.lastname: Zhan
authors.forename: Sheng-Ping
authors.initials: SP
authors.lastname: Yang
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
mesh_terms: D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D028481:Euphorbia / Q000737:chemistry*; D008516:Medicine, Chinese Traditional; D010084:Oxidation-Reduction; D012639:Seeds / Q000737:chemistry
chemical_list: D004224:Diterpenes; C506856:lathyranoic acid A