Design and synthesis of novel antidiabetic agents.
The synthesis and structure-activity relationships of a novel series of substituted quercetins that activates peroxisome proliferator-activated receptor gamma (PPARgamma) are reported. The PPARgamma agonistic activity of the most potent compound in this series is comparable to that of the thiazolidinedione-based antidiabetic drugs currently in clinical use.
Lee
Joon Yeol
JY
College of Pharmacy & Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, Korea.
Park
Won-Hui
WH
Cho
Min-Kyoung
MK
Yun
Hyun Jin
HJ
Chung
Byung-Ho
BH
Pak
Youngmi Kim
YK
Hahn
Hoh-Gyu
HG
Cheon
Seung Hoon
SH
D000818:Animals; D002478:Cells, Cultured; D018076:DNA, Complementary / Q000096:biosynthesis / Q000235:genetics; D015195:Drug Design; D005347:Fibroblasts / Q000378:metabolism; D005822:Genetic Vectors; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D047495:PPAR gamma / Q000235:genetics; D010957:Plasmids; D011794:Quercetin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D014162:Transfection
D018076:DNA, Complementary; D007004:Hypoglycemic Agents; D007202:Indicators and Reagents; D047495:PPAR gamma; D011794:Quercetin