Ventral abdominal wall dysmorphogenesis of Msx1/Msx2 double-mutant mice.
Msx1 and Msx2 genes encode the homeodomain transcription factors. Several gene knockout mice and expression studies suggest that they possess functionally redundant roles in embryogenesis. In this study, we revealed that Msx1 and Msx2 were expressed during ventral body wall formation in an overlapping manner. Msx1/Msx2 double-mutant mice displayed embryonic abdominal wall defects with disorganized muscle layers and connective tissues. These findings indicate that Msx1 and Msx2 play roles in concert during embryonic ventral abdominal wall formation.
Ogi
Hidenao
H
Center for Animal Resources and Development, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.
Suzuki
Kentaro
K
Ogino
Yukiko
Y
Kamimura
Mika
M
Miyado
Mami
M
Ying
Xu
X
Zhang
Zunyi
Z
Shinohara
Masanori
M
Chen
Yiping
Y
Yamada
Gen
G
D000009:Abdominal Muscles / Q000002:abnormalities* / Q000378:metabolism / Q000473:pathology; D034861:Abdominal Wall / Q000002:abnormalities* / Q000473:pathology; D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D047108:Embryonic Development; D005260:Female; D018507:Gene Expression Regulation, Developmental; D020022:Genetic Predisposition to Disease; D046449:Hernia, Abdominal / Q000151:congenital / Q000235:genetics; D018398:Homeodomain Proteins / Q000235:genetics* / Q000378:metabolism; D017403:In Situ Hybridization; D051957:MSX1 Transcription Factor; D008297:Male; D051379:Mice; D018345:Mice, Knockout
D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; D051957:MSX1 Transcription Factor; C084119:MSX2 protein; C484084:Msx1 protein, mouse