Ciprofloxacin-protected gold nanoparticles.
The antibacterial drug ciprofloxacin (cfH) has been used to protect gold nanoparticles of two different mean diameters, 4 and 20 nm. The protection is complete with about 65 and 585 cfH molecules covering 4 and 15 nm particles, respectively. The nature of binding has been investigated by several analytical techniques. The nitrogen atom of the NH moiety of piperazine group binds on the gold surface, as revealed by voltammetric and spectroscopic studies. The cfH-adsorbed particles are stable in the dry state as well as at room temperature, and as a result, redispersion is possible. The rate of release of the drug molecule from the nanoparticles is more in the basic medium than in pure water, and the kinetics depend on the size of the particle; faster desorption is seen in smaller particles. The bound cfH is fluorescent, and this property could be used in biological investigations. This study shows that metal nanoparticles could be useful carriers for cfH and fluoroquinolone molecules. Most of the bound molecules could be released over an extended period of time.
Tom
Renjis T
RT
Department of Chemistry and Regional Sophisticated Instrumentation Centre, Indian Institute of Technology Madras, Chennai 600 036, India.
Suryanarayanan
V
V
Reddy
P Ganapati
PG
Baskaran
S
S
Pradeep
T
T
D000327:Adsorption; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002939:Ciprofloxacin / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission / Q000379:methods; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure
D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D002939:Ciprofloxacin; D006046:Gold