[Observing the distribution of Annexin I and cPLA2 in the palatal process of mice by immunohistochemical staining].
OBJECTIVE
To observe the distribution of Annexin I and cytosolic phospholipose A2 (cPLA2) in the palatal process of dexamethasome teratogenerated mice.


METHODS
Cutting along the coronary plane of the heads of fetal mice to obtain palate in the 14th, 15th, 16th day of gestation by 10-week-old in-bred mice. The distribution of Annexin I and cPLA2 was checked by immunohistochemical staining.


RESULTS
During the fusing of the palatal processes, the staining of Annexin I and cPLA2 was positive in the epithelial and mesenchymal cells of the palatal process, and the intensity of staining changed with time.


CONCLUSIONS
Annexin I and cPLA2 can modulate the development of fetal palate to some extent, and they may be important mediators in the development of cleft palate induced by dexamethasone.
Wang
Yan
Y
Key Laboratory of Oral Biomedical Engineering of Ministry of Education, Sichuan University, Chengdu 610041, China.
Shi
Bing
B
Zuo
Hui
H
Huang
Lei
L
D000818:Animals; D017305:Annexin A1; D002972:Cleft Palate; D003907:Dexamethasone; D005938:Glucocorticoids; D051379:Mice; D013194:Staining and Labeling
D017305:Annexin A1; D005938:Glucocorticoids; D003907:Dexamethasone