title: Diffuse normolipemic plane xanthoma in a 9-year-old boy.
abstract: Normolipemic plane xanthoma normally occurs in adults. We report the atypical instance of a 9-year-old boy who developed disseminated, flat, yellow-brown plaques up to 2 to 3 cm without any complaints. The histology showed the hallmarks of xanthoma, including the presence of CD68+ foam cells and Touton giant cells. No systemic involvement or lipid disorders were evident. It is important to perform regular follow-up of these patients because normolipemic plane xanthoma often precedes myeloproliferative disorders such as leukemia, paraproteinemia, or lymphoma.
authors.affiliation: Department of Dermatology and Allergy, Charité, University Medicine Berlin, Germany. maja.hofmann@charite.de
authors.forename: Maja
authors.initials: M
authors.lastname: Hofmann
authors.forename: Kristina
authors.initials: K
authors.lastname: Zappel
authors.forename: Uwe
authors.initials: U
authors.lastname: Trefzer
authors.forename: Heike
authors.initials: H
authors.lastname: Audring
authors.forename: Helga
authors.initials: H
authors.lastname: Albrecht-Nebe
authors.forename: Wolfram
authors.initials: W
authors.lastname: Sterry
authors.forename: Ulrike
authors.initials: U
authors.lastname: Blume-Peytavi
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D001706:Biopsy; D002648:Child; D006801:Humans; D008297:Male; D012871:Skin Diseases / Q000378:metabolism / Q000473:pathology*; D014973:Xanthomatosis / Q000378:metabolism / Q000473:pathology*; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule