[Expression and significance of angiopoietins in oral squamous cell carcinoma].
OBJECTIVE
To observe the expression of angiopoietins in oral squamous cell carcinoma and relationship between the expression of angiopoietins and pathologic classification.


METHODS
The expression of Ang-1 and Ang-2 protein in samples from 42 oral squamous cell carcinoma and 16 oral normal mucosa were detected by immunohistochemical technique.


RESULTS
The expression of Ang-1 and Ang-2 was found in both oral squamous cell carcinoma and normal control. It was found Ang-1 expression alike in oral squamous cell carcinoma and control (P > 0.05). Ang-2 expressed at low level in control while strongly positive in oral squamous cell caroinoma and the level of Ang-2 expression in oral squamous cell caroinoma was related to pathologic classification (P < 0.05).


CONCLUSIONS
Ang-2 expression in oral squamous cell carcinoma is related to angiogenesis and pathological classification, which is probably involved in angiogenesis regulation, promotes the development and metastasis of oral squamous cell carcinoma.
Wu
Yun-xia
YX
Dental Department, the First Affiliated Hospital, Shanxi Medical University, Taiyuan, China.
Liang
Ping
P
Nan
Xin-rong
XR
Jiao
Yan-jun
YJ
Sun
Xiao-jun
XJ
D042683:Angiopoietin-1; D042702:Angiopoietin-2; D042682:Angiopoietins; D002294:Carcinoma, Squamous Cell; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa; D009062:Mouth Neoplasms; D009369:Neoplasms; D009389:Neovascularization, Pathologic
C467630:ANGPT1 protein, human; D042683:Angiopoietin-1; D042702:Angiopoietin-2; D042682:Angiopoietins