Linking epithelial-mesenchymal transition to the well-known polarity protein Par6.
Epithelial-mesenchymal transition (EMT) is involved in the formation of the body plan, tissue remodeling, and cancer progression. Two recent reports in Science (Barrios-Rodiles et al., 2005; Ozdamar et al., 2005) have decisively advanced our understanding of EMT. Par6 was identified as a key player in the control of tight junction (TJ) stability. This new study provides further insight into the protein networks involved in topologically regulated control of epithelial cell polarity and plasticity.
Thiery
Jean Paul
JP
CNRS UMR 144, Translational Research Department, Institut Curie, 26 Rue d'Ulm, 75248 Paris, Cedex 05, France.
Huang
Ruby
R
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins / Q000378:metabolism*; D016764:Cell Polarity; D004847:Epithelial Cells / Q000502:physiology*; D006801:Humans; D008648:Mesoderm / Q000166:cytology / Q000502:physiology*; D009024:Morphogenesis; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism; D019108:Tight Junctions / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; C499657:PARD6A protein, human; D018125:Receptors, Transforming Growth Factor beta