title: Abnormal visual search in mild cognitive impairment and Alzheimer's disease.
abstract: Our aim was to further characterize the clinical concept of mild cognitive impairment (MCI). We examined the status of visual attention-related processing in such patients in relation to healthy older adults and patients with Alzheimer's disease (AD) by measuring performance on a computer-based visual search task. We tested 20 older adult control participants, 13 patients with amnestic mild cognitive impairment and 12 patients with AD. Patients with AD and with MCI exhibited a significant detriment in visual search performance compared to the older adult controls. The deficit in visual search was greater for the patients with AD than the patients with MCI. The pattern of results displayed by the MCI group indicates that patients who appear clinically to suffer only from a deficit in memory also display a deficit in visual attention-related processing, which although not as severe as those with AD, represents a significant detriment in such performance compared to that seen in healthy ageing.
authors.affiliation: Department of Care of the Elderly University of Bristol, Clinical Research Centre and Memory Disorders Clinic, The BRACE Centre, Blackberry Hill Hospital, Bristol, UK. Andrea.Tales@north-bristol.swest.nhs.uk
authors.forename: Andrea
authors.initials: A
authors.lastname: Tales
authors.forename: Judy
authors.initials: J
authors.lastname: Haworth
authors.forename: Sara
authors.initials: S
authors.lastname: Nelson
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Snowden
authors.forename: Gordon
authors.initials: G
authors.lastname: Wilcock
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000503:physiopathology*; D000704:Analysis of Variance; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008609:Mental Status Schedule / Q000706:statistics & numerical data; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D010469:Perceptual Distortion / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods; D011930:Reaction Time / Q000502:physiology; D014796:Visual Perception / Q000502:physiology*