title: Second primary malignancies in patients with male breast cancer.
abstract: An international multicentre study of first and second primary neoplasms associated with male breast cancer was carried out by pooling data from 13 cancer registries. Among a total of 3409 men with primary breast cancer, 426 (12.5%) developed a second neoplasia; other than breast cancer, a 34% overall excess risk of second primary neoplasia, affecting the small intestine (standardised incidence ratio, 4.95, 95% confidence interval, 1.35-12.7), rectum (1.78, 1.20-2.54), pancreas (1.93, 1.14-3.05), skin (nonmelanoma, 1.65, 1.16-2.29), prostate (1.61, 1.34-1.93) and lymphohaematopoietic system (1.63, 1.12-2.29). A total of 225 male breast cancers was recorded after cancers other than breast cancer, but an increase was found only after lymphohaematopoietic neoplasms. BRCA2 (and to some extent BRCA1) mutations may explain the findings for pancreatic and prostate cancers. Increases at other sites may be related to unknown factors or to chance. This large study shows that the risks for second discordant tumours after male breast cancer pose only a moderate excess risk.
authors.affiliation: Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, Heidelberg D-69120, Germany. khemminki@dkfz.de
authors.forename: K
authors.initials: K
authors.lastname: Hemminki
authors.forename: G
authors.initials: G
authors.lastname: Scélo
authors.forename: P
authors.initials: P
authors.lastname: Boffetta
authors.forename: L
authors.initials: L
authors.lastname: Mellemkjaer
authors.forename: E
authors.initials: E
authors.lastname: Tracey
authors.forename: A
authors.initials: A
authors.lastname: Andersen
authors.forename: D H
authors.initials: DH
authors.lastname: Brewster
authors.forename: E
authors.initials: E
authors.lastname: Pukkala
authors.forename: M
authors.initials: M
authors.lastname: McBride
authors.forename: E V
authors.initials: EV
authors.lastname: Kliewer
authors.forename: K-S
authors.initials: KS
authors.lastname: Chia
authors.forename: V
authors.initials: V
authors.lastname: Pompe-Kirn
authors.forename: C
authors.initials: C
authors.lastname: Martos
authors.forename: J G
authors.initials: JG
authors.lastname: Jonasson
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.forename: P
authors.initials: P
authors.lastname: Brennan
mesh_terms: D000328:Adult; D000368:Aged; D018567:Breast Neoplasms, Male / Q000150:complications*; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000453:epidemiology* / Q000209:etiology; D012042:Registries / Q000706:statistics & numerical data*; D012307:Risk Factors