title: The effect on IMRT conformality of elastic tissue movement and a practical suggestion for movement compensation via the modified dynamic multileaf collimator (dMLC) technique.
abstract: A major remaining problem in delivering radiotherapy, specifically intensity-modulated radiation therapy (IMRT), is the need to accommodate and correct for intrafraction movement. The developing availability of 4D computed tomographic images can potentially form the basis of the new field of image-guided IMRT. It is important to understand the effects on delivered dose of the patient breathing during IMRT and this paper models the effect which applies whether there is or is not a time component to the IMRT delivery method. It then goes on to suggest a practical correction strategy. The 'stretch-and-shift-the-planned-modulations' strategy is proposed and a practical method to deliver this is explained. This practical strategy is based on a modification of the dynamic multileaf collimator IMRT method whereby the leaves are arranged to 'breath' in tandem with the breathing of the patient. Some examples are also given from a study of mismatching the patient and leaf-correction motions.
authors.affiliation: Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey, SM2 5PT, UK.
authors.forename: S
authors.initials: S
authors.lastname: Webb
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D003238:Connective Tissue / Q000000981:diagnostic imaging / Q000503:physiopathology; D004548:Elasticity; D006801:Humans; D008954:Models, Biological; D009068:Movement; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods*; D015656:Respiratory Mechanics