Neuroprotective effects of prostaglandin A1 in animal models of focal ischemia.
The present study evaluated the neuroprotective potential of prostaglandin A1 (PGA1) in rodent models of focal cerebral ischemia. PGA1 33 nmol reduced infarction volume by about 43% (P < 0.05) when administered intracerebroventricularly before and after transient ischemia in mice. PGA1 16.5-66 nmol diminished infarction volume by 18% to 27% (P < 0.01) when administered immediately following permanent ischemia in rats. PGA1 treatment also significantly ameliorated motor dysfunction after brain ischemia. These results suggest that PGA1 protects neurons from ischemic injury.
Zhang
Hui-Ling
HL
Department of Pharmacology, Soochow University School of Medicine, 48 Ren Ming Road, Suzhou 215007, PR China.
Huang
Zhi Hong
ZH
Zhu
Yi
Y
Liang
Zhong-Qing
ZQ
Han
Rong
R
Wang
Xiao-Xia
XX
Chase
Thomas N
TN
Qin
Zheng-Hong
ZH
D000704:Analysis of Variance; D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy / Q000473:pathology*; D004195:Disease Models, Animal; D020244:Infarction, Middle Cerebral Artery / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000473:pathology; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D011454:Prostaglandins A / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley
D018696:Neuroprotective Agents; D011454:Prostaglandins A; C100573:prostaglandin A1