title: How do thiazide and thiazide-like diuretics lower blood pressure?
abstract: Thiazide diuretics are widely used for the treatment of hypertension, but the mechanism by which these drugs lower blood pressure in the long term remains unknown. This article reviews current knowledge about the hypotensive actions of thiazides and thiazide-like diuretics and discusses possible mechanisms of action.
authors.affiliation: Clinical Pharmacology, Faculty of Medicine, Imperial College London, London W21NY, UK. a.hughes@imperial.ac.uk
authors.forename: Alun D
authors.initials: AD
authors.lastname: Hughes
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001581:Benzothiadiazines; D001794:Blood Pressure / Q000187:drug effects*; D004232:Diuretics / Q000494:pharmacology*; D006801:Humans; D049993:Sodium Chloride Symporter Inhibitors / Q000494:pharmacology*; D013449:Sulfonamides / Q000494:pharmacology*
chemical_list: D000959:Antihypertensive Agents; D001581:Benzothiadiazines; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D013449:Sulfonamides