title: Structure-activity relationship studies on tetralin carboxamide growth hormone secretagogue receptor antagonists.
abstract: The structure-activity relationship studies on a series of tetralin carboxamide growth hormone secretagogue receptor (GHS-R) antagonists are discussed. It was found that certain 2-alkoxycarbonylamino substituted tetralin carboxamides are potent, selective, and orally bioavailable GHS-R antagonists.
authors.affiliation: Metabolic Disease Research, Global Pharmaceutical Research and Development, R4MC, AP-10, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6098, USA. hongyu.zhao@abbott.com
authors.forename: Hongyu
authors.initials: H
authors.lastname: Zhao
authors.forename: Zhili
authors.initials: Z
authors.lastname: Xin
authors.forename: Jyoti R
authors.initials: JR
authors.lastname: Patel
authors.forename: Lissa T J
authors.initials: LT
authors.lastname: Nelson
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.forename: Bruce G
authors.initials: BG
authors.lastname: Szczepankiewicz
authors.forename: Verlyn G
authors.initials: VG
authors.lastname: Schaefer
authors.forename: H Douglas
authors.initials: HD
authors.lastname: Falls
authors.forename: Wiweka
authors.initials: W
authors.lastname: Kaszubska
authors.forename: Christine A
authors.initials: CA
authors.lastname: Collins
authors.forename: Hing L
authors.initials: HL
authors.lastname: Sham
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
mesh_terms: D000284:Administration, Oral; D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001665:Binding Sites; D001682:Biological Availability; D015195:Drug Design; D020128:Inhibitory Concentration 50; D010655:Phenylenediamines / Q000737:chemistry; D051381:Rats; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors* / Q000378:metabolism; D054440:Receptors, Ghrelin; D013329:Structure-Activity Relationship; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
chemical_list: D000577:Amides; D010655:Phenylenediamines; D043562:Receptors, G-Protein-Coupled; D054440:Receptors, Ghrelin; D013764:Tetrahydronaphthalenes; C095210:tetralin