Henoch-Schönlein purpura in a child with hyperimmunoglobulinemia D and periodic fever syndrome.
This report describes a 3-year-old girl with a long history of periodic fever who presented with Henoch-Schönlein purpura. She was diagnosed with hyperimmunoglobulinemia D and periodic fever syndrome by means of mutation analysis of the mevalonate kinase gene. The serum IgA concentration was markedly elevated, but the serum IgD concentration was normal. This report emphasizes that Henoch-Schönlein purpura may be an important clinical feature of hyperimmunoglobulinemia D and periodic fever syndrome. In addition, this syndrome should be considered in patients with Henoch-Schonlein purpura in whom there is a history of recurrent fevers, even when the serum IgD concentration is normal.
Wickiser
Jonathan E
JE
Department of Pediatrics, University of Virginia Health System, Charlottesville, Virginia 22908, USA.
Saulsbury
Frank T
FT
D015746:Abdominal Pain / Q000209:etiology; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002675:Child, Preschool; D005076:Exanthema / Q000209:etiology; D010505:Familial Mediterranean Fever / Q000150:complications* / Q000473:pathology; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D006942:Hypergammaglobulinemia / Q000097:blood / Q000150:complications* / Q000473:pathology; D011695:IgA Vasculitis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D007070:Immunoglobulin A / Q000097:blood; D007072:Immunoglobulin D / Q000097:blood; D011241:Prednisone / Q000627:therapeutic use; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D007070:Immunoglobulin A; D007072:Immunoglobulin D; D011241:Prednisone