title: Inv(1)(p22q25) in chronic myeloproliferative disease: constitutional or clonal defect?
abstract: Pericentric inversion of chromosome 1 is uncommon in chronic myeloproliferative disease. We report the occurrence of an isolated inv(1)(p22q25) in two patients with BCR/ABL-negative chronic myeloproliferative disease. The inv(1) is an acquired clonal abnormality in one patient and a constitutional defect in the other. To our knowledge, this is the first report on the occurrence of inv(1)(p22q25) in hematolymphoid malignancies.
authors.affiliation: Department of Pathology, Queen Elizabeth Hospital, 30 Gascoigne Road, Hong Kong SAR, China. kfwong@ha.org.hk
authors.forename: K F
authors.initials: KF
authors.lastname: Wong
authors.forename: W C
authors.initials: WC
authors.lastname: Wong
authors.forename: W
authors.initials: W
authors.lastname: Cheuk
mesh_terms: D000368:Aged; D002871:Chromosome Banding; D007446:Chromosome Inversion; D002878:Chromosomes, Human, Pair 1; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000235:genetics* / Q000473:pathology