Choroidal perfusion measurements made with optical coherence tomography.
Choroidal perfusion measurements are complicated by the choroid's location posterior to the retina and its associated retinal blood vessels. Optical coherence tomography is a relatively new imaging technique with sufficient spatial resolution to isolate choroidal backscattering events from the posterior eye. We modified a speckle imaging algorithm to analyze sequential axial depth scans obtained from posterior rat eye to obtain an indicator of choroidal perfusion. This indicator is correlated with known changes in choroidal blood flow in response to increased intraocular pressure.
Wu
Frank I
FI
Department of Biomedical Engineering, Northwestern University, Tech Building E310, 2145 Sheridan Road, Evanston, Illinois 60201, USA.
Glucksberg
Matthew R
MR
D000465:Algorithms; D000818:Animals; D001185:Artificial Intelligence; D001783:Blood Flow Velocity / Q000502:physiology*; D002829:Choroid / Q000098:blood supply* / Q000166:cytology / Q000502:physiology*; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D016247:Information Storage and Retrieval / Q000379:methods; D009887:Ophthalmoscopy / Q000379:methods*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods*