[Protective effects of phosphoramidon on the experimental myocardial injury in rats].
OBJECTIVE
To investigate the protective effects of phosphoramidon on the experimental myocardial injury in rats.


METHODS
Thirty-six Wistar rats were randomly divided into 3 groups of 12: the control group (Control), the isoproterenol group (ISO) and the protection group (PA). All rats were anesthetized after 24 hours and the blood was sampled from the carotid artery. The activities of creatine phosphokinase (CPK) and lactic dehydrogenase (LDH) in the serum and the contents of ET in the plasma were detected; then the hearts were isolated and the total layers of apical myocardium were solidified, embedded, sectioned, stained with HE and graded pathologically.


RESULTS
The serum activities of CPK and LDH, and the plasmatic content of ET in the ISO group were significantly higher than those in the control group and PA group (P < 0.05); the degree of myocardial pathological damage in the ISO group was significantly higher than that in the control group (P < 0.01), while the degree of damage in the PA group was lower than that in the ISO group (P < 0.05).


CONCLUSIONS
Endothelin is involved in the pathologic process of experimental myocardial injury in rats. Phosphoramidon can protect the myocardial injury in rats and its mechanism may be to inhibit ECE and reduce the endothelins production.
He
Fei
F
Department of Cardiology, Xiangya Hospital, Central South University, Changsha, China.
Sun
Ming
M
Guo
Rong
R
D000818:Animals; D003402:Creatine Kinase / Q000378:metabolism*; D016232:Endothelins / Q000378:metabolism; D005260:Female; D006020:Glycopeptides / Q000494:pharmacology*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D009203:Myocardial Infarction / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D016232:Endothelins; D006020:Glycopeptides; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; D008666:Metalloendopeptidases; C008890:phosphoramidon