title: [A proposal for diagnostic and clinical assessment criteria for Alzheimer's disease].
abstract: To clarify the risk and associated genes of Alzheimer's disease by genome-wide screening, a Japanese study group was organized in 2000 under Yasuo Ihara, Tokyo University, supported by a Grant-in-Aid for Science Research on Priority Areas (C) -Advanced Brain Science Project from Ministry of Education, Culture, Sports, Science and Technology, Japan. This is the first Japanese consortium study under permission of the ethical committees of the enrolled institutes based on the ethics guidelines for human genome/gene analysis research, Ministry of Education, Culture, Sports, Science and Technology Ministry of Health, Labor and Welfare Ministry of Economy, Trade and Industry. In this project, 2,000 genome samples from patients with Alzheimer's disease, 2,000 control subjects, and 200 siblings affected with Alzheimer's disease are collected and analyzed. For this purpose, it is necessary to analyze samples from accurately diagnosed Alzheimer patients and controls using standard criteria for diagnosis and neuropsychological evaluation, which have been confirmed by an evidence-based studying a Japanese population. Here, we propose criteria for the diagnosis and clinical assessment of Alzheimer's disease. This proposal consists of a definition of Alzheimer's disease based on recent advances in research, diagnostic criteria based on DSM-IV, NINCDS-ADRDA and ICD-10, exclusion criteria for other dementia disorders, routine and detailed tests for neuropsychological and laboratory evaluations, criteria for neuroimaging and biomarkers, definitive diagnostic criteria and classification of clinical subtypes.
authors.affiliation: Department of Neurology, Neuroscience, Biophysiological Science, Okayama University Graduate School of Medicine and Dentistry.
authors.forename: Mikio
authors.initials: M
authors.lastname: Shoji
authors.forename: Ryozo
authors.initials: R
authors.lastname: Kuwano
authors.forename: Takasi
authors.initials: T
authors.lastname: Asada
authors.forename: Masaki
authors.initials: M
authors.lastname: Imagawa
authors.forename: Susumu
authors.initials: S
authors.lastname: Higuchi
authors.forename: Katsuya
authors.initials: K
authors.lastname: Urakami
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Arai
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ihara
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis*; D006801:Humans; D007564:Japan