Convergent synthesis of internally branched PAMAM dendrimers.
[reaction: see text] A series of aliphatic internally branched poly(amido amine) dendrons and dendrimers has been synthesized. The internal branching unit was 1,2-propanediamine and a series of PAMAM-type dendrons of the types AB2, AB4, and AB8 were built. These were anchored on a core molecule containing four carboxylic acid moieties and the 1,2-propanediamine unit resulted in PAMAM dendrimers with 4, 8, 16, and 32 end groups.
Pittelkow
Michael
M
Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100, Denmark.
Christensen
Jørn B
JB