Bone mass acquisition in healthy children.
Although 80% of the variance in bone mass is determined genetically, there are many other factors which influence the accumulation of bone in early life and affect future risks of osteoporosis. This review considers the genetic, fetal, and environmental influences on bone mass acquisition in healthy children, and highlights important areas where paediatricians may have a role by counselling children and their families to adopt a healthy lifestyle which promotes bone health.
Davies
J H
JH
Department of Child Health, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. daviesjh@cf.ac.uk
Evans
B A J
BA
Gregory
J W
JW
D000293:Adolescent; D015519:Bone Density / Q000235:genetics / Q000502:physiology*; D001846:Bone Development / Q000235:genetics / Q000502:physiology*; D002118:Calcium / Q000008:administration & dosage; D002648:Child; D002664:Child Nutritional Physiological Phenomena / Q000502:physiology; D024042:Collagen Type I / Q000235:genetics; D004032:Diet; D015444:Exercise / Q000502:physiology; D047109:Fetal Development / Q000502:physiology; D050723:Fractures, Bone / Q000209:etiology; D006128:Growth / Q000502:physiology*; D006728:Hormones / Q000502:physiology; D006801:Humans; D026502:LDL-Receptor Related Proteins; D060492:Low Density Lipoprotein Receptor-Related Protein-5; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics; D011973:Receptors, LDL / Q000235:genetics; D014807:Vitamin D / Q000008:administration & dosage
D024042:Collagen Type I; D006728:Hormones; D026502:LDL-Receptor Related Proteins; C555482:LRP5 protein, human; D060492:Low Density Lipoprotein Receptor-Related Protein-5; D018167:Receptors, Calcitriol; D011973:Receptors, LDL; D014807:Vitamin D; D002118:Calcium