title: Genetic factors in neuromuscular pain.
abstract: Recent evidence suggests that fibromyalgia, a chronic widespread pain condition and related syndromes (chronic fatigue syndrome, irritable bowel syndrome, etc.) may share heritable pathophysiologic features. We review the recent literature on genetic and familial factors found to participate in the pathogenesis of these syndromes, specifically fibromyalgia, including evidence suggesting that serotonin- and dopamine-related genes may play a role in the pathogenesis of these illnesses. The importance of environmental factors triggering these conditions in predisposed individuals is also discussed.
authors.affiliation: Department of Internal Medicine, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84101, Israel. dbuskila@bgumail.bgu.ac.il
authors.forename: Dan
authors.initials: D
authors.lastname: Buskila
authors.forename: Lily
authors.initials: L
authors.lastname: Neumann
authors.forename: Joseph
authors.initials: J
authors.lastname: Press
mesh_terms: D004298:Dopamine / Q000235:genetics; D004777:Environment; D005356:Fibromyalgia / Q000235:genetics* / Q000503:physiopathology*; D005819:Genetic Markers; D006801:Humans; D012701:Serotonin / Q000235:genetics
chemical_list: D005819:Genetic Markers; D012701:Serotonin; D004298:Dopamine