Effects of peripheral chemoreceptors deactivation on sympathetic activity in heart transplant recipients.
Heart transplantation initially normalizes sympathetic hyperactivity directed at the muscle circulation. However, sympathetic activity increases with time after transplantation and the exact mechanisms responsible for sympathetic control in heart transplant recipients remain unclear. We examined the effects of peripheral chemoreflex deactivation caused by breathing 100% oxygen on muscle sympathetic nerve activity (expressed as number of burst per minute and mean burst amplitude), heart rate, and mean blood pressure in 13 heart transplant recipients, 13 patients with essential hypertension, and 10 controls. Heart transplant recipients disclosed the highest sympathetic activity, whereas it did not differ between controls and patients with essential hypertension (51+/-16 versus 37+/-14 versus 39+/-12 burst/min, respectively; P<0.05). Breathing 100% oxygen, in comparison with 21% oxygen, reduced sympathetic activity (-4+/-4 versus -1+/-2 burst/min, P<0.01; 85+/-9 versus 101+/-8% of amplitude at baseline, P<0.001) and mean blood pressure (-4+/-5 versus +3+/-6 mm Hg; P<0.05) in heart transplant recipients, decreased sympathetic activity (-4+/-4 versus 0+/-3 burst/min, P<0.05; 90+/-16 versus 101+/-9% of amplitude at baseline, P<0.05) in patients with essential hypertension, but did not reduce sympathetic activity (2+/-4 versus 3+/-3 burst/min, P=NS; 95+/-11 versus 95+/-13% of amplitude at baseline, P=NS) in control subjects. The sympathetic response to hyperoxia was more marked in heart transplant recipients than in controls (85+/-9 versus 95+/-11% of baseline amplitude; P<0.05). The decrease in sympathetic activity was most evident in patients with the longest time after heart transplantation (r=-0.75, P<0.01). In conclusion, tonic chemoreflex activation increases resting muscle sympathetic nerve activity and favors blood pressure elevation after heart transplantation.
Ciarka
Agnieszka
A
Department of Cardiology, Erasme University Hospital, Brussels, Belgium. Agnieszka.Ciarka@ulb.ac.be
Najem
Boutaïna
B
Cuylits
Nicolas
N
Leeman
Marc
M
Xhaet
Olivier
O
Narkiewicz
Krzysztof
K
Antoine
Martine
M
Degaute
Jean-Paul
JP
van de Borne
Philippe
P
D000280:Administration, Inhalation; D000368:Aged; D001794:Blood Pressure; D002628:Chemoreceptor Cells / Q000503:physiopathology*; D018592:Cross-Over Studies; D003714:Denervation / Q000379:methods; D004311:Double-Blind Method; D006339:Heart Rate; D016027:Heart Transplantation; D006801:Humans; D018496:Hyperoxia / Q000139:chemically induced / Q000503:physiopathology; D006973:Hypertension / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000294:innervation*; D010100:Oxygen / Q000008:administration & dosage; D011184:Postoperative Period; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D013997:Time Factors
D010100:Oxygen