title: Defining and measuring reproductive concerns of female cancer survivors.
abstract: Although women diagnosed with cancer during their childbearing years are at significant risk for infertility, we know little about the relationship between infertility and long-term quality of life (QOL). To examine these relationships, we assessed psychosocial and reproductive concerns and QOL in 231 female cancer survivors. Greater reproductive concerns were significantly associated with lower QOL on numerous dimensions (P<.001). In a multiple regression model, social support, gynecologic problems, and reproductive concerns accounted for 63% of the variance in QOL scores. Women who reported wanting to conceive after cancer, but were not able to, reported significantly more reproductive concerns than those who were able to reproduce after cancer (P<.001). These preliminary data suggest that at least for vulnerable subgroups, the issue of reproductive concerns is worthy of additional investigation to assist cancer survivors living with the threat or reality of infertility.
authors.affiliation: University of California, Irvine, Center for Health Policy Research, Department of Medicine, College of Medicine, 111 Academy Way, Ste. 220, Irvine, CA 92697-5800, USA. lwenzel@uci.edu
authors.forename: Lari
authors.initials: L
authors.lastname: Wenzel
authors.forename: Aysun
authors.initials: A
authors.lastname: Dogan-Ates
authors.forename: Rana
authors.initials: R
authors.lastname: Habbal
authors.forename: Ross
authors.initials: R
authors.lastname: Berkowitz
authors.forename: Donald P
authors.initials: DP
authors.lastname: Goldstein
authors.forename: Marilyn
authors.initials: M
authors.lastname: Bernstein
authors.forename: Brenda Coffey
authors.initials: BC
authors.lastname: Kluhsman
authors.forename: Kathryn
authors.initials: K
authors.lastname: Osann
authors.forename: Edward
authors.initials: E
authors.lastname: Newlands
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Seckl
authors.forename: Barry
authors.initials: B
authors.lastname: Hancock
authors.forename: David
authors.initials: D
authors.lastname: Cella
mesh_terms: D000328:Adult; D001007:Anxiety; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology* / Q000523:psychology*; D008223:Lymphoma / Q000150:complications* / Q000523:psychology*; D011247:Pregnancy; D011788:Quality of Life; D012044:Regression Analysis; D012307:Risk Factors; D012944:Social Support; D017741:Survivors; D002583:Uterine Cervical Neoplasms / Q000150:complications* / Q000523:psychology*