Discovery of powerful uranyl ligands from efficient synthesis and screening.
New tripodal gem-(bis-phosphonates) uranophiles were discovered by a screening method that allowed for the selection of ligands with strong uranyl-binding properties in a convenient microtiter-plate format. The method is based on competitive uranium binding by using Sulfochlorophenol S as chromogenic chelate. This dye compound was found to present high uranyl complexation properties and allowed to highlight ligands presenting association constants for UO(2+)(2) up to 10(18) at pH 7.4 and 10(20) at pH 9. A collection of 40 known ligands including polycarboxylate, hydroxamate, catecholate, hydroxypyridonate and hydroxyquinoline derivatives was tested. Also screened was a combinatorial library prepared from seven amine scaffolds and eight acrylates bearing diverse chelating moieties. Among these 96 tested candidates, a tripod derivative bearing gem-bis-phosphonates moieties was found to present the highest complexation properties over a wide range of pH and was further studied.
Sawicki
Marcin
M
Service de Marquage Moléculaire et de Chimie Bio-organique, DBJC/DSV CEA-Saclay, Gif sur Yvette, France.
Siaugue
Jean-Michel
JM
Jacopin
Christophe
C
Moulin
Christophe
C
Bailly
Théodorine
T
Burgada
Ramon
R
Meunier
Stéphane
S
Baret
Paul
P
Pierre
Jean-Louis
JL
Taran
Frédéric
F
D006863:Hydrogen-Ion Concentration; D008024:Ligands; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D013450:Sulfones / Q000737:chemistry*; D014501:Uranium / Q000737:chemistry*
D008024:Ligands; D009281:Naphthalenes; D009942:Organometallic Compounds; D013450:Sulfones; C506869:sulfochlorophenol S; D014501:Uranium