title: Butyrylcholinesterase inhibitory guaianolides from Amberboa ramosa.
abstract: Phytochemical investigation of the whole plant of Amberboa ramosa led to the isolation of six sesquiterpene lactones which could be identified as 8alpha-hydroxy-11beta-methyl-1alphaH, 5alphaH, 6betaH, 7alphaH, 11alphaH-guai-10(14), 4(15)-dien-6, 12-olide(1), 3beta, 8alpha-dihydroxy-11alpha-methyl-1alphaH, 5alphaH, 6betaH, 7alphaH, 11betaH-guai-10(14), 4 (15)-dien-6, 12-olide (2), 3beta, 4alpha, 8alpha-trihydroxy-4beta-(hydroxymethyl)-1alphaH, 5alphaH, 6betaH, 7alphaH-guai-10(14), 11(13)-dien-6, 12-olide (3), 3beta, 4alpha, 8alpha-trihydroxy-4beta-(chloromethyl)-1alphaH, 5alphaH, 6betaH, 7alphaH-guai-10(14),11(13)-dien-6, 12-olide(4), 3beta, 4alpha, dihydroxy-4beta-(hydroxymethyl)-1alphaH, 5alphaH, 6betaH, 7alphaH-guai-10(14),11(13)-dien-6, 12-olide(5), 3beta, 4alpha-dihydroxy-4beta-(chloromethyl)-8alpha-(4-hydroxymethacrylate)-1alphaH, 5alphaH, 6betaH, 7alphaH-guai-10(14),11 (13)-dien-6,12-olide (6) by spectroscopic methods. All of them showed inhibitory potential against butyrylcholinesterase.
authors.affiliation: International Centre for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
authors.forename: Sher Bahadar
authors.initials: SB
authors.lastname: Khan
authors.lastname: Azhar-ul-Haq
authors.forename: Shagufta
authors.initials: S
authors.lastname: Perveen
authors.forename: Nighat
authors.initials: N
authors.lastname: Afza
authors.forename: Abdul
authors.initials: A
authors.lastname: Malik
authors.forename: Sarfraz Ahmad
authors.initials: SA
authors.lastname: Nawaz
authors.forename: Muhammad Raza
authors.initials: MR
authors.lastname: Shah
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D019659:Asteraceae / Q000737:chemistry*; D002091:Butyrylcholinesterase / Q000378:metabolism*; D002800:Cholinesterase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D005702:Galantamine / Q000494:pharmacology; D007700:Kinetics; D045789:Sesquiterpenes, Guaiane / Q000302:isolation & purification / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared
chemical_list: D002800:Cholinesterase Inhibitors; D045789:Sesquiterpenes, Guaiane; D005702:Galantamine; D002091:Butyrylcholinesterase