title: Hemiparkinsonism and levodopa-induced dyskinesias after focal nigral lesion.
abstract: We present a patient with tremor-dominant hemiparkinsonism after a focal lesion to the substantia nigra. An excellent response to levodopa was complicated by rapid development of motor fluctuations and disabling dyskinesias. Stereotactic thalamotomy resulted in a persistent extinction of parkinsonism and of dyskinesias along with stopping dopaminergic treatment.
authors.affiliation: Movement Disorders Center, 1st Medical Faculty, Charles University, Katerinská 30, CZ-120 100 Prague, Czech Republic. eruzi@lf1.cuni.cz
authors.forename: Evzen
authors.initials: E
authors.lastname: Růzicka
authors.forename: Dusan
authors.initials: D
authors.lastname: Urgosík
authors.forename: Robert
authors.initials: R
authors.lastname: Jech
authors.forename: Jan
authors.initials: J
authors.lastname: Roth
authors.forename: Josef
authors.initials: J
authors.lastname: Vymazal
authors.forename: Petr
authors.initials: P
authors.lastname: Mecír
authors.forename: Vilibald
authors.initials: V
authors.lastname: Vladyka
mesh_terms: D000328:Adult; D000978:Antiparkinson Agents / Q000009:adverse effects*; D004409:Dyskinesia, Drug-Induced / Q000209:etiology* / Q000473:pathology*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging / Q000379:methods; D020734:Parkinsonian Disorders / Q000150:complications / Q000188:drug therapy; D013378:Substantia Nigra / Q000187:drug effects* / Q000293:injuries / Q000473:pathology*
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa