title: Insulin-like 6 immunoreactivity in the mouse brain and testis.
abstract: Insulin-like 6 immunoreactivity (irINSL6) was detected in Leydig cells of the mouse testis. In the brain, labeled somata were detected mainly in the caudal hypothalamus and midbrain. Double labeling the brainstem sections revealed that irINSL6 somata were 5-hydroxytryptamine (5-HT) positive. The presence of irINSL6 in discrete populations of hypothalamic and brainstem neurons and in Leydig cells of the testis suggests a diverse biological function of this novel peptide.
authors.affiliation: Department of Pharmacology, Temple University School of Medicine, 3420 N. Broad Street, Philadelphia, PA 19140, USA.
authors.forename: G Cristina
authors.initials: GC
authors.lastname: Brailoiu
authors.forename: Siok L
authors.initials: SL
authors.lastname: Dun
authors.forename: Deling
authors.initials: D
authors.lastname: Yin
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Jaw Kang
authors.initials: JK
authors.lastname: Chang
authors.forename: Nae J
authors.initials: NJ
authors.lastname: Dun
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D001923:Brain Chemistry / Q000502:physiology*; D005260:Female; D007150:Immunohistochemistry; D007328:Insulin / Q000031:analogs & derivatives* / Q000032:analysis* / Q000096:biosynthesis; D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D013737:Testis / Q000737:chemistry* / Q000378:metabolism
chemical_list: C512664:Insl6 protein, mouse; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins