title: Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD.
abstract: There is increasing evidence that genetic variants of mitochondrial DNA have an important role in the cause of idiopathic Parkinson's disease. We determined the mitochondrial DNA haplogroup of 455 Parkinson's disease cases, 185 Alzheimer's disease cases, and 447 healthy English control subjects. The UKJT haplogroup cluster was associated with a 22% reduction in population-attributable risk for Parkinson's disease. There was no association between individual haplogroups or the UKJT cluster and Alzheimer's disease, confirming that the association with Parkinson's disease was disease specific and not a general effect seen in all neurodegenerative diseases.
authors.affiliation: Mitochondrial Research Group, The University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom.
authors.forename: Angela
authors.initials: A
authors.lastname: Pyle
authors.forename: Thomas
authors.initials: T
authors.lastname: Foltynie
authors.forename: Watcharee
authors.initials: W
authors.lastname: Tiangyou
authors.forename: Claire
authors.initials: C
authors.lastname: Lambert
authors.forename: Sharon M
authors.initials: SM
authors.lastname: Keers
authors.forename: Liesl M
authors.initials: LM
authors.lastname: Allcock
authors.forename: Jill
authors.initials: J
authors.lastname: Davison
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Lewis
authors.forename: Robert H
authors.initials: RH
authors.lastname: Perry
authors.forename: Roger
authors.initials: R
authors.lastname: Barker
authors.forename: David J
authors.initials: DJ
authors.lastname: Burn
authors.forename: Patrick F
authors.initials: PF
authors.lastname: Chinnery
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D004272:DNA, Mitochondrial