Myxobacterial epothilones and tubulysins as promising anticancer agents.
Tubulin-binding agents play a pivotal role in current cancer therapy and there are many efforts in pre-clinical and clinical development of known and novel cytotoxic agents ongoing. In this article a known class, epothilones, as well as a novel class, tubulysins, are presented.
Dömling
Alexander
A
R&D Biopharmaceuticals, München, Germany. alexander.doemling@t-online.de
Richter
Wolfgang
W
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D004640:Emetine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D009231:Myxococcales / Q000737:chemistry*; D014404:Tubulin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D014404:Tubulin; C009805:tubulosine; D004640:Emetine