Anti-invasive activity of niacin and trigonelline against cancer cells.
The effects of niacin, namely, nicotinic acid and nicotinamide, and trigonelline on the proliferation and invasion of cancer cells were studied using a rat ascites hepatoma cell line of AH109A in culture. Niacin and trigonelline inhibited the invasion of hepatoma cells at concentrations of 2.5-40 microM without affecting proliferation. Hepatoma cells previously cultured with a reactive oxygen species (ROS)-generating system showed increased invasive activity. Niacin and trigonelline suppressed this ROS-potentiated invasive capacity through simultaneous treatment of AH109A cells with the ROS-generating system. The present study indicates for the first time the anti-invasive activities of niacin and trigonelline against cancer cells.
Hirakawa
Nobuhiro
N
Department of Applied Biological Science, Tokyo Noko University, Fuchu, Japan.
Okauchi
Rieko
R
Miura
Yutaka
Y
Yagasaki
Kazumi
K
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D045744:Cell Line, Tumor; D005434:Flow Cytometry; D008114:Liver Neoplasms, Experimental / Q000473:pathology*; D009361:Neoplasm Invasiveness / Q000517:prevention & control*; D009525:Niacin / Q000494:pharmacology*; D051381:Rats; D017382:Reactive Oxygen Species
D000470:Alkaloids; D017382:Reactive Oxygen Species; D009525:Niacin; C009560:trigonelline