Resveratrol and breast cancer chemoprevention: molecular mechanisms.
Despite years of intensive research, breast cancer remains a major cause of death among women. New strategies to combat breast cancer are being developed, one of the most exciting of which is the use of chemopreventive agents. Resveratrol (RES) is a polyphenolic compound found in plants that seems to have a wide spectrum of biological activity. RES has been shown to afford protection against several types of cancer. This review summarizes the chemopreventive effects of RES at the three major stages of breast carcinogenesis: initiation, promotion, and progression. It has anti-oxidant and anti-inflammatory properties, and may induce apoptosis as well as modulate cell cycle and estrogen receptor function in breast cancer cell lines. Although RES has shown remarkable promise as a potent chemopreventive agent in breast cancer, further studies are needed to etablish its usefulness.
Le Corre
Ludovic
L
Laboratoire d'Oncologie Moléculaire, CBRV, Centre Jean Perrin, Clermont-Ferrand, France.
Chalabi
N
N
Delort
L
L
Bignon
Yves-Jean
YJ
Bernard-Gallon
D J
DJ
D000893:Anti-Inflammatory Agents; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D000975:Antioxidants; D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000473:pathology / Q000517:prevention & control*; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D048789:Phytoestrogens; D000077185:Resveratrol; D015398:Signal Transduction / Q000187:drug effects; D013267:Stilbenes / Q000494:pharmacology / Q000627:therapeutic use*; D015262:Xenobiotics / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D016588:Anticarcinogenic Agents; D000975:Antioxidants; D048789:Phytoestrogens; D013267:Stilbenes; D015262:Xenobiotics; D019869:Phosphatidylinositol 3-Kinases; D000077185:Resveratrol