Drug-induced hypersensitivity syndrome due to anticonvulsants in a two-year-old boy.
Drug-induced hypersensitivity syndrome (DIHS) usually refers to severe cutaneous drug eruption associated with systemic involvement and potentially fatal outcome. We report a 2-year-old Caucasian boy who developed DIHS due to phenytoin and phenobarbital and who showed extensive internal organ involvement. We are alerting that failure to recognize this drug eruption and discontinue the culprit drug may result in increased severity, greater extent of internal organ involvement, and fatal outcome. The recent research about the influence of human herpesvirus 6 co-infection on the pathogenesis of DIHS is also discussed by the authors in this paper.
Criado
Paulo Ricardo
PR
Dermatology Unit, Complexo Hospitalar Padre Bento de Guarulhos, Brazil.
Criado
Roberta F J
RF
Vasconcellos
Cidia
C
Pegas
Jose Roberto P
JR
Cera
Patrícia Calil
PC
D000927:Anticonvulsants / Q000009:adverse effects*; D002675:Child, Preschool; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D008297:Male; D010634:Phenobarbital / Q000009:adverse effects; D010672:Phenytoin / Q000009:adverse effects; D012640:Seizures / Q000188:drug therapy
D000927:Anticonvulsants; D010672:Phenytoin; D010634:Phenobarbital