title: Transcutaneous oxygen tension monitoring after successful revascularization in diabetic patients with ischaemic foot ulcers.
abstract: OBJECTIVE
  To monitor transcutaneous oxygen tension (TcPO2) after percutaneous transluminal angioplasty (PTA) in diabetic patients with ischaemic foot ulcers.
  
  
  METHODS
  Twenty-three diabetic patients with ischaemic foot ulcers who underwent successful revascularization by PTA (SR group) were retrospectively selected. Twenty diabetic patients who underwent unsuccessful revascularization (UR group) were also included. Transcutaneous oxygen tension was measured at the dorsum of the foot before and 1 (+/- 1), 7 (+/- 1), 14 (+/- 1), 21 (+/- 1) and 28 (+/- 1) days after the surgical procedure.
  
  
  RESULTS
  After PTA, TcPO2 progressively improved in the SR group, reaching its peak 4 weeks after angioplasty. A concomitant decrease of cutaneous carbon dioxide tension (TcPCO2) was also observed immediately after PTA which reached the lowest levels 3 weeks later. In the UR group, TcPO2 showed a slight improvement immediately after PTA but remained stable throughout the observation, while TcPCO2 levels did not change. Finally, the percentage of SR patients with a TcPO2 > or = 30 mmHg was 38.5% 1 week after PTA, while it increased to 75% 3 weeks later.
  
  
  CONCLUSIONS
  Transcutaneous oxygen tension monitoring showed that after successful revascularization it takes 3-4 weeks for cutaneous oxygenation to improve and reach the optimal levels for wound healing. Transcutaneous carbon dioxide tension monitoring may be more useful to identify the negative outcome of a revascularization procedure. Our findings suggest that, when the surgical approach can be delayed, the best timing to perform a more aggressive debridement or minor amputations is 3-4 weeks after successful revascularization.
authors.affiliation: Department of Internal Medicine, University of Tor Vergata, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Caselli
authors.forename: V
authors.initials: V
authors.lastname: Latini
authors.forename: A
authors.initials: A
authors.lastname: Lapenna
authors.forename: S
authors.initials: S
authors.lastname: Di Carlo
authors.forename: F
authors.initials: F
authors.lastname: Pirozzi
authors.forename: A
authors.initials: A
authors.lastname: Benvenuto
authors.forename: L
authors.initials: L
authors.lastname: Uccioli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000800:Angioplasty, Balloon; D001785:Blood Gas Monitoring, Transcutaneous; D003646:Debridement; D017719:Diabetic Foot / Q000097:blood / Q000601:surgery / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D012039:Regional Blood Flow; D012189:Retrospective Studies; D012867:Skin / Q000098:blood supply; D013997:Time Factors
chemical_list: D010100:Oxygen