The majority of human genes have regions repeated in other human genes.
Amino acid sequence comparisons have been made between all of 25,193 human proteins with each of the others by using blast software (National Center for Biotechnology Information) and recording the results for regions that are significantly related in sequence, that is, have an expectation of <1 x 10(-3). The results are presented for each amino acid as the number of identical or similar amino acids matched in these aligned regions. This approach avoids summing or dealing directly with the different regions of any one protein that are often related to different numbers and types of other proteins. The results are presented graphically for a sample of 140 proteins. Relationships are not observed for 26.5% of the 12,728,866 amino acids. The average number of related amino acids is 36.5 for the majority (73.5%) that show relationships. The median number of recognized relationships is approximately 3 for all of the amino acids, and the maximum number is 718. The results demonstrate the overwhelming importance of gene regional duplication forming families of proteins with related domains and show the variety of the resulting patterns of relationship. The magnitude of the set of relationships leads to the conclusion that the principal process by which new gene functions arise has been by making use of preexisting genes.
Britten
Roy J
RJ
California Institute of Technology, 101 Dahlia Avenue, Corona del Mar, CA 92625, USA. r.britten@comcast.net
D020087:Alu Elements / Q000235:genetics; D000596:Amino Acids / Q000032:analysis / Q000235:genetics; D019295:Computational Biology; D019143:Evolution, Molecular; D020440:Gene Duplication; D023281:Genomics; D006801:Humans; D011506:Proteins / Q000737:chemistry* / Q000235:genetics*; D040901:Proteomics; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D016335:Zinc Fingers / Q000235:genetics
D000596:Amino Acids; D011506:Proteins