title: [Molecular and cellular changes following exposure to tobacco smoke causing laryngeal cancer. An outline of the problem].
abstract: The incidence of laryngeal cancer is strongly connected with exposure to tobacco smoke containing at least 40 genotoxic carcinogens. DNA lesions induced by tobacco smoke carcinogens can be turned into stable mutations. Oncogenes and tumor suppressor genes are first of all responsible for initiation of carcinogenesis. The same time cells provide such self-protection processes as: carcinogen detoxication, DNA repair and apoptosis. The initiation of carcinogenesis followed by oncogenesis results from the competition between DNA lesions/mutations formation and the protection processes; the latter are genetically controlled.
authors.affiliation: Institut Genetyki Człowieka Polskiej Akademii Nauk w Poznaniu. szyfkris@man.poznan.pl
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Szyfter
mesh_terms: D002273:Carcinogens / Q000378:metabolism; D004249:DNA Damage; D004260:DNA Repair; D016147:Genes, Tumor Suppressor; D006801:Humans; D007822:Laryngeal Neoplasms / Q000139:chemically induced / Q000378:metabolism*; D009154:Mutation; D012907:Smoking / Q000009:adverse effects*
chemical_list: D002273:Carcinogens