Incidence of seizures in patients with multiple sclerosis treated with intrathecal baclofen.
Oral and intrathecal baclofen (ITB) have been associated with epileptic seizures. The authors observed a higher incidence of epileptic seizures in 99 patients with multiple sclerosis (MS) treated with ITB vs a matched control group (7% vs 1%, p < 0.05). Three patients with MS on ITB developed status epilepticus. Seizures were often associated with additional triggering factors.
Schuele
S U
SU
Department of Neurology/S91, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. schules@ccf.org
Kellinghaus
C
C
Shook
S J
SJ
Boulis
N
N
Bethoux
F A
FA
Loddenkemper
T
T
D000328:Adult; D001418:Baclofen / Q000009:adverse effects*; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D018755:GABA Agonists / Q000009:adverse effects; D006801:Humans; D015994:Incidence; D007260:Infusion Pumps / Q000009:adverse effects; D007278:Injections, Spinal / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000503:physiopathology; D009128:Muscle Spasticity / Q000188:drug therapy / Q000503:physiopathology / Q000517:prevention & control; D012189:Retrospective Studies; D012640:Seizures / Q000139:chemically induced* / Q000453:epidemiology*
D018755:GABA Agonists; D001418:Baclofen