A note on linkage analysis with affected sib triplets.
Previously, it has been shown for affected sib pairs that the mean test is the uniformly (in theta) most powerful test in case of a multiplicative mode of inheritance and that the mean test is equivalent to parametric linkage analysis calculated under an assumed multiplicative mode of inheritance. Here, these two results are extended to samples consisting of affected sib triplets. For affected sib quadruplets, however, it is shown that these results are no longer valid.
Knapp
Michael
M
Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany. knapp@uni-bonn.de
D030342:Genetic Diseases, Inborn / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008957:Models, Genetic; D011783:Quadruplets / Q000235:genetics; D014310:Triplets / Q000235:genetics*
D005819:Genetic Markers