Heat-shock proteins induce T-cell regulation of chronic inflammation.
Immune responses to certain heat-shock proteins (HSPs) develop in almost all inflammatory diseases; however, the significance of such responses is only now becoming clear. In experimental disease models, HSPs can prevent or arrest inflammatory damage, and in initial clinical trials in patients with chronic inflammatory disease, HSP-derived peptides have been shown to promote the production of anti-inflammatory cytokines, indicating that HSPs have immunoregulatory potential. In this Review, we discuss the unique characteristics of HSPs that endow them with these immunoregulatory qualities.
van Eden
Willem
W
Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584CL Utrecht, The Netherlands. w.eden@vet.uu.nl
van der Zee
Ruurd
R
Prakken
Berent
B
D000818:Animals; D001161:Arteriosclerosis / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism; D001168:Arthritis / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism; D018834:Chaperonin 60 / Q000276:immunology / Q000378:metabolism*; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism; D018840:HSP70 Heat-Shock Proteins / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*
D018834:Chaperonin 60; D018840:HSP70 Heat-Shock Proteins