Mechanisms associated with unusual orofacial pain.
This article presents an overview of possible mechanisms associated with pain perception, with a specific focus on understanding unusual manifestations of orofacial pain associated with nerve insult. It includes recent evidence concerning neurobiological changes that occur in the periphery at tissue and nerve sites, or within the central nervous system, and that may involve chemical and inflammatory responses, sensitization, or alterations of cellular function. Moreover, the contribution of the autonomic nervous system, changes in emotional reactivity and vigilance, the roles of high brain centers such as the basal ganglia (nigro-striatal) system, and the influence of aging and gender, are briefly described.
Lavigne
Gilles
G
Quebec Oral Health Research Network (FRSQ), Faculties of Dentistry and Medicine Université de Montréal Montreal, Québec, Canada. gilles.lavigne@umontreal.ca
Woda
Alain
A
Truelove
Edmond
E
Ship
Jonathan A
JA
Dao
Thuan
T
Goulet
Jean-Paul
JP
D000344:Afferent Pathways; D001479:Basal Ganglia / Q000503:physiopathology; D002054:Burning Mouth Syndrome / Q000503:physiopathology; D005157:Facial Pain / Q000503:physiopathology* / Q000523:psychology; D005356:Fibromyalgia / Q000503:physiopathology; D006801:Humans; D009433:Neural Inhibition; D020078:Neurogenic Inflammation / Q000503:physiopathology; D018377:Neurotransmitter Agents / Q000502:physiology; D014098:Toothache / Q000503:physiopathology; D061221:Trigeminal Nerve Injuries
D018377:Neurotransmitter Agents