title: Nematocidal and trichomonacidal activities of 2-substituted quinolines.
abstract: Several quinolines were synthesized and evaluated in vitro and in vivo against the nematodes Caenorhabditis elegans, Heligmosomoides polygyrus and the protozoa Trichomonas vaginalis. If some of them have shown in vitro nematocide activity (at 10 microM), however, their trichomonacidal activity reached 50% reduction at only 100 microM. The in vivo activity on Trichinella spiralis model was evaluated for some of the most in vitro active quinolines.
authors.affiliation: Departamento de Parasitología, Universidad Complutense, 28040 Madrid, Spain.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Martínez-Grueiro
authors.forename: Consuelo
authors.initials: C
authors.lastname: Giménez-Pardo
authors.forename: Alicia
authors.initials: A
authors.lastname: Gómez-Barrio
authors.forename: Xavier
authors.initials: X
authors.lastname: Franck
authors.forename: Alain
authors.initials: A
authors.lastname: Fournet
authors.forename: Reynald
authors.initials: R
authors.lastname: Hocquemiller
authors.forename: Bruno
authors.initials: B
authors.lastname: Figadère
authors.forename: Nieves
authors.initials: N
authors.lastname: Casado-Escribano
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000994:Antitrichomonal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D009348:Nematoda / Q000187:drug effects*; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D017160:Trichinella spiralis / Q000187:drug effects; D014246:Trichomonas vaginalis / Q000187:drug effects*
chemical_list: D000969:Antinematodal Agents; D000994:Antitrichomonal Agents; D011804:Quinolines