Nematocidal and trichomonacidal activities of 2-substituted quinolines.
Several quinolines were synthesized and evaluated in vitro and in vivo against the nematodes Caenorhabditis elegans, Heligmosomoides polygyrus and the protozoa Trichomonas vaginalis. If some of them have shown in vitro nematocide activity (at 10 microM), however, their trichomonacidal activity reached 50% reduction at only 100 microM. The in vivo activity on Trichinella spiralis model was evaluated for some of the most in vitro active quinolines.
Martínez-Grueiro
Mercedes
M
Departamento de Parasitología, Universidad Complutense, 28040 Madrid, Spain.
Giménez-Pardo
Consuelo
C
Gómez-Barrio
Alicia
A
Franck
Xavier
X
Fournet
Alain
A
Hocquemiller
Reynald
R
Figadère
Bruno
B
Casado-Escribano
Nieves
N
D000818:Animals; D000969:Antinematodal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000994:Antitrichomonal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D009348:Nematoda / Q000187:drug effects*; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D017160:Trichinella spiralis / Q000187:drug effects; D014246:Trichomonas vaginalis / Q000187:drug effects*
D000969:Antinematodal Agents; D000994:Antitrichomonal Agents; D011804:Quinolines