[The condition of the stomach, duodenum and bile ducts in patients with chronic hepatitis C].
OBJECTIVE
To study the status of the stomach, duodenum and biliary tracts in young patients with chronic hepatitis C.


METHODS
We studied associated pathology of the gastroduodenal zone and biliary tract in 140 patients with CHC aged 16 to 35 years (mean age 25 +/- 0.8 years). We used USI and MRT of the abdominal organs, fibroesophagogastroduodenoscopy with biopsy of gastric mucosa for H. pylori, fractional duodenal tubing. 30 healthy males were controls.


RESULTS
Asymtomatic gastroduodenal and biliary defects were found (75.5%). Endoscopic signs of gastroduodenal lesions were frequent (76.3%) in CHC patients, the majority of them were associated with H. Pylori and were not significantly different from those in the controls. Biliary tracts pathology, as shown by USI and MRT, occurred in 50.8%, were primarily functional (74.5%) and combined with high occurrence of bile mixed microflora with predominance of B. Fragilis (81%). Correlation of pathological changes of the gastroduodenal zone and biliary tract was established in CHC patients. How ever, they do not correlate with clinicolaboratory and histological signs of HCV infection. CONCLUSION. Young patients with CHC demonstrated no correlation between pathological changes of the gastroduodenal zone, biliary tracts and clinicolaboratory, histological signs of HCV infection. Therefore, it is recommended not to eradicate HP-infection and not to suppress opportunistic bile microflora in CHC young patients in the absence of clinical symptoms of gastrointestinal changes.
Lobzin
Iu V
IuV
Zhdanov
K V
KV
Gusev
D A
DA
Iaremenko
M V
MV
D000293:Adolescent; D000328:Adult; D001649:Bile Duct Diseases / Q000175:diagnosis* / Q000453:epidemiology*; D001652:Bile Ducts / Q000000981:diagnostic imaging* / Q000473:pathology*; D004386:Duodenum / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D005767:Gastrointestinal Diseases / Q000175:diagnosis* / Q000453:epidemiology*; D016481:Helicobacter Infections / Q000453:epidemiology* / Q000382:microbiology; D019698:Hepatitis C, Chronic / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013270:Stomach / Q000000981:diagnostic imaging* / Q000382:microbiology / Q000473:pathology*; D014463:Ultrasonography