Green T(R) cells.
Identification of the transcription factor Foxp3 as a "master regulator" of regulatory T (T(R)) cells was a major discovery. A new study by Fontenot et al. (2005), reported in this issue of Immunity, provides novel insights into T(R) cell biology by tracking their behavior in mice expressing a GFP-Foxp3 fusion-protein reporter.
Feuerer
Markus
M
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.
Benoist
Christophe
C
Mathis
Diane
D
D000818:Animals; D004268:DNA-Binding Proteins / Q000276:immunology*; D003952:Diagnostic Imaging; D051858:Forkhead Transcription Factors; D051379:Mice; D011993:Recombinant Fusion Proteins / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D004268:DNA-Binding Proteins; D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; D011993:Recombinant Fusion Proteins