[An experirmental study on the preparation and drug sustained release characteristics of Pingyangmycin Albumin Microspheres].
OBJECTIVE
The aim of this study was to prepare Pingyangmycin Albumin Microspheres (PYM-AMS) for arteriovenous malformations treatment.


METHODS
PYM-AMS was prepared at 140 degrees C by the method of emulsification-heat solidification and its characteristics were evaluated, such as morphosis, particle size, drug loading (DL%), encapsulation efficiency (EE%), stability and drug sustained-releasing in vitro. After being packaged, PYM-AMS were sterilized with 13.7 kGy of 60Co. Small samples of PYM-AMS were packaged in small bottles and stored at 3 - 5 degrees C, 15 - 25 degrees C, 37 degrees C for 3 months, then checked the change of morphology, DL, EE and the release rate.


RESULTS
The surface of particles was smooth and integrated. The average diameter of PYM-AMS particles was 139.422 microm and 80% was in the range of 56 - 251 microm. The mean DL% and EE% were 26.47% and 84.3%, respectively. PYM released fast in 5 h, but then released slowly. 88.65% drugs were released in 24 h, and t50 was 1.5 h. There was no obvious change of the morphology, DL,EE and the release rate of PYM-AMS stored at 3 - 5 degrees C 15 - 25 degrees C, 37 degrees C for 3 months.


CONCLUSIONS
PYM-AMS prepared in this study had sustained-release effect, high drug loading and high stability. Albumin is a good carrier of PYM embolization agent.
Gao
Qing-hong
QH
Key Laboratory of Oral Biomedical Engineering of Ministry of Education, Sichuan University, Chengdu 610041, China.
Zheng
Gen-jian
GJ
Wang
Chang-guang
CG
Zhou
Lan
L
Wen
Yu-ming
YM
Wang
Chang-mei
CM
Hou
Shi-xiang
SX
D000418:Albumins; D001761:Bleomycin / Q000031:analogs & derivatives; D003692:Delayed-Action Preparations; D008863:Microspheres; D010316:Particle Size
D000418:Albumins; D003692:Delayed-Action Preparations; D001761:Bleomycin; C025703:bleomycetin