Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD.
There is increasing evidence that genetic variants of mitochondrial DNA have an important role in the cause of idiopathic Parkinson's disease. We determined the mitochondrial DNA haplogroup of 455 Parkinson's disease cases, 185 Alzheimer's disease cases, and 447 healthy English control subjects. The UKJT haplogroup cluster was associated with a 22% reduction in population-attributable risk for Parkinson's disease. There was no association between individual haplogroups or the UKJT cluster and Alzheimer's disease, confirming that the association with Parkinson's disease was disease specific and not a general effect seen in all neurodegenerative diseases.
Pyle
Angela
A
Mitochondrial Research Group, The University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom.
Foltynie
Thomas
T
Tiangyou
Watcharee
W
Lambert
Claire
C
Keers
Sharon M
SM
Allcock
Liesl M
LM
Davison
Jill
J
Lewis
Simon J
SJ
Perry
Robert H
RH
Barker
Roger
R
Burn
David J
DJ
Chinnery
Patrick F
PF
D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic
D004272:DNA, Mitochondrial