Simultaneous spectrophotometric determination of salbutamol and bromhexine in tablets.
Typical anti-mucolytic drugs called salbutamol hydrochloride and bromhexine sulfate encountered in tablets were determined simultaneously either by using linear regression at zero-crossing wavelengths of the first derivation of UV-spectra or by application of multiple linear partial least squares regression method. The results obtained by the two proposed mathematical methods were compared with those obtained by the HPLC technique.
Habib
I H I
IH
Microanalytical Chem. Lab, Applied Organic Chem. Department, National Research Centre, Dokki, Cairo, Egypt. ihihabib@yahoo.com <ihihabib@yahoo.com>
Hassouna
M E M
ME
Zaki
G A
GA
D000420:Albuterol / Q000032:analysis*; D000465:Algorithms; D000996:Antitussive Agents / Q000032:analysis*; D001964:Bromhexine / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D004364:Pharmaceutical Preparations / Q000032:analysis; D012044:Regression Analysis; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013607:Tablets / Q000737:chemistry
D000996:Antitussive Agents; D004364:Pharmaceutical Preparations; D013607:Tablets; D001964:Bromhexine; D000420:Albuterol