title: Clinical and electrophysiological course of acute syphilitic posterior placoid chorioretinitis.
abstract: BACKGROUND
  Syphilis can affect the anterior as well as the posterior segment of the eye at any stage.
  
  
  METHODS
  A 52-year-old man was referred to our clinic because of acute loss of his vision and hearing. Best corrected visual acuity (BCVA) was counting fingers (CF) right and 0.05 left eye, respectively. Fundoscopy revealed bilateral intraretinal macular haemorrhages and a large yellowish edematous lesion involving macula and midperipheral retina. Fluorescein angiography showed diffuse late edema. The visual field showed a defect corresponding to the edematous lesion. The "Ganzfeld" electroretinogram (ERG) was markedly reduced and the multifocal ERG in the affected area was not recordable.
  
  
  RESULTS
  VDRL, FTA-Abs and TPHA tests in serum and cerebrospinal fluid were positive. Intravenous penicillin therapy was initiated. BCVA, visual field and ERG eventually recovered completely.
  
  
  CONCLUSIONS
  Syphilis should be considered as a differential diagnosis in any unclear inflammatory ocular condition. Awareness of syphilitic posterior placoid chorioretinitis allows rapid diagnosis and therapy.
authors.affiliation: Department of Ophthalmology, University Hospital, Zurich, Switzerland. s.menon@gmx.net
authors.forename: S R
authors.initials: SR
authors.lastname: Menon
authors.forename: J
authors.initials: J
authors.lastname: Fleischhauer
authors.forename: K
authors.initials: K
authors.lastname: Jost
authors.forename: H
authors.initials: H
authors.lastname: Helbig
mesh_terms: D000328:Adult; D001766:Blindness / Q000209:etiology; D002825:Chorioretinitis / Q000175:diagnosis* / Q000188:drug therapy; D003937:Diagnosis, Differential; D004596:Electroretinography; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D003639:Hearing Loss, Sudden / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy; D013587:Syphilis / Q000175:diagnosis* / Q000188:drug therapy; D014787:Vision Tests