The relationships between plasma total homocysteine and selected atherosclerotic risk factors according to the C677T methylenetetrahydrofolate reductase gene in Japanese.
BACKGROUND
Variation of plasma total homocysteine (tHcy) levels among individuals is modified by 5,10-methylenetetrahydrofolate reductase (MTHFR) genotypes and selected atherosclerotic risk factors.


METHODS
Cross-sectional study.


METHODS
Healthy Japanese men (n=213) and women (n=242) aged 40-69 years were examined.


RESULTS
Serum uric acid, hemoglobin, hematocrit, serum creatinine, and men were independently significantly associated with plasma tHcy. The relationship between serum uric acid and plasma tHcy was the strongest in those with the mutant homozygote (VV), but the overall statistical test of interaction was not significant.


CONCLUSIONS
Serum uric acid, hematocrit, hemoglobin, creatinine, and men were determinants of plasma tHcy levels. Further investigations are needed.
Lwin
Htay
H
Division of Health and Nutrition Monitoring, National Institute of Health and Nutrition, Tokyo, Japan. htay@nih.go.jp
Yoshiike
Nobuo
N
Yokoyama
Tetsuji
T
Saito
Kyoko
K
Date
Chigusa
C
Tanaka
Heizo
H
D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000453:epidemiology / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D003430:Cross-Sectional Studies; D005260:Female; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D005838:Genotype; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012016:Reference Values; D018570:Risk Assessment; D012680:Sensitivity and Specificity
D006710:Homocysteine; D042965:Methylenetetrahydrofolate Reductase (NADPH2)