Molecular mechanisms of cholesterol absorption and transport in the intestine.
Many enzymes and transport proteins participate in cholesterol absorption. This review summarizes recent results on several proteins that are important for each step of the cholesterol absorption pathway, including the important roles of: (i) pancreatic triglyceride lipase (PTL), carboxyl ester lipase (CEL), and ileal bile acid transporter in determining the rate of cholesterol absorption; (ii) ATP binding cassette (ABC) transporters and the Niemann-Pick C-1 like-1 (NPC1L1) protein as intestinal membrane gatekeepers for cholesterol efflux and influx; and (iii) intracellular membrane vesicles and transport proteins in lipid trafficking through intracellular compartments prior to lipoprotein assembly and secretion to plasma circulation.
Hui
David Y
DY
Department of Pathology, University of Cincinnati Genome Research Institute, Cincinnati, OH 45237-0507, USA. huidy@email.uc.edu
Howles
Philip N
PN
D018528:ATP-Binding Cassette Transporters / Q000378:metabolism; D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism*; D020895:Enterocytes / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D051379:Mice; D008823:Micelles; D010179:Pancreas / Q000201:enzymology
D018528:ATP-Binding Cassette Transporters; D001647:Bile Acids and Salts; D008823:Micelles; D002784:Cholesterol