title: In vitro and in vivo cytotoxicities and antileishmanial activities of thymol and hemisynthetic derivatives.
abstract: The in vitro and in vivo antileishmanial and cytotoxic activities of thymol and structural derivatives in comparison to those of Glucantime were studied. The results showed here suggest that thymol and hemisynthetic derivatives have promising antileishmanial potential and could be considered as new lead structures in the search for novel antileishmanial drugs.
authors.affiliation: Programa de Estudio y Control de Enfermedades Tropicales PECET, Universidad de Antioquia, Medellín, Colombia. srobledo@guajiros.udea.edu.co
authors.forename: Sara
authors.initials: S
authors.lastname: Robledo
authors.forename: Edison
authors.initials: E
authors.lastname: Osorio
authors.forename: Diana
authors.initials: D
authors.lastname: Muñoz
authors.forename: Luz Marina
authors.initials: LM
authors.lastname: Jaramillo
authors.forename: Adriana
authors.initials: A
authors.lastname: Restrepo
authors.forename: Gabriel
authors.initials: G
authors.lastname: Arango
authors.forename: Iván
authors.initials: I
authors.lastname: Vélez
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006224:Cricetinae; D005260:Female; D006801:Humans; D007891:Leishmania / Q000187:drug effects; D007896:Leishmaniasis / Q000188:drug therapy / Q000469:parasitology; D008297:Male; D008536:Meglumine / Q000494:pharmacology / Q000627:therapeutic use; D000077485:Meglumine Antimoniate; D009942:Organometallic Compounds / Q000494:pharmacology / Q000627:therapeutic use; D021261:Parasitic Sensitivity Tests; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D013943:Thymol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D020298:U937 Cells
chemical_list: D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D013729:Terpenes; D013943:Thymol; D008536:Meglumine; D000077485:Meglumine Antimoniate