Mechanisms of B-cell lymphoma pathogenesis.
Chromosomal translocations involving the immunoglobulin loci are a hallmark of many types of B-cell lymphoma. Other factors, however, also have important roles in the pathogenesis of B-cell malignancies. Most B-cell lymphomas depend on the expression of a B-cell receptor (BCR) for survival, and in several B-cell malignancies antigen activation of lymphoma cells through BCR signalling seems to be an important factor for lymphoma pathogenesis. Recent insights into the lymphomagenic role of factors supplied by the microenvironment also offer new therapeutic strategies.
Küppers
Ralf
R
Institute for Cell Biology (Tumor Research), University of Duisburg-Essen, Medical School, Germany. ralf.kuppers@uni-essen.de
D002450:Cell Communication; D005803:Genes, Immunoglobulin; D016147:Genes, Tumor Suppressor; D018858:Germinal Center / Q000502:physiology; D006801:Humans; D016393:Lymphoma, B-Cell / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D009154:Mutation; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism; D015398:Signal Transduction; D014178:Translocation, Genetic
D011947:Receptors, Antigen, B-Cell