Indels and imperfect duplication have driven the evolution of human Complement Receptor 1 (CR1) and CR1-like from their precursor CR1 alpha: importance of functional sets.
This study examines the effects of duplication and insertions-deletions (indels) by comparing human complement receptor 1 (CR1) and human CR1-like (CR1L) with syntenic genes from four other vertebrates (chimpanzee, baboon, rat, and mouse). By phylogenetic analysis, the domains of these genes can be classified into 10 distinct subfamilies (a, b, c, d, e, f, g(-like), h, j, and k), which have been largely conserved throughout vertebrate and invertebrate evolution. In spite of many complex and diverse duplications and indels, the subfamily order of domains (a, j, e, f, b, k, d, g(-like)) has been maintained. The number of domain sets has increased progressively, thereby expanding the functional repertoire.
McLure
C A
CA
Centre for Molecular Immunology and Instrumentation, University of Western Australia, Nedlands, Canning Vale South, Western Australia.
Williamson
J F
JF
Stewart
B J
BJ
Keating
P J
PJ
Dawkins
R L
RL
D000595:Amino Acid Sequence; D000818:Animals; D000954:Antigens, Surface; D019143:Evolution, Molecular; D020440:Gene Duplication; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D002679:Pan troglodytes / Q000235:genetics; D048548:Papio cynocephalus / Q000235:genetics; D048529:Papio hamadryas / Q000235:genetics; D051381:Rats; D011956:Receptors, Cell Surface; D011951:Receptors, Complement / Q000235:genetics*; D017463:Receptors, Complement 3b / Q000235:genetics*; D016415:Sequence Alignment
D000954:Antigens, Surface; C482970:CR1L protein, human; C081470:Cr1l protein, mouse; C513105:Cr1l protein, rat; D011956:Receptors, Cell Surface; D011951:Receptors, Complement; D017463:Receptors, Complement 3b