title: Use of cardiac resynchronization therapy to optimize beta-blocker therapy in patients with heart failure and prolonged QRS duration.
abstract: A retrospective analysis was performed on 52 patients with heart failure to determine the change in beta-blocker therapy after cardiac resynchronization therapy (CRT). After 6 months of CRT, the number of patients receiving beta-blocker therapy increased from 36 to 44, with improved clinical outcomes and larger beta-blocker doses, indicating that these 2 therapies may work together to improve outcomes by allowing the use of larger doses of beta blockers while correcting ventricular dyssynchrony.
authors.affiliation: Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida, USA. arandjm@mail-cs.med.ufl.edu
authors.forename: Juan M
authors.initials: JM
authors.lastname: Aranda
authors.forename: Gregory W
authors.initials: GW
authors.lastname: Woo
authors.forename: Jamie B
authors.initials: JB
authors.lastname: Conti
authors.forename: Richard S
authors.initials: RS
authors.lastname: Schofield
authors.forename: C Richard
authors.initials: CR
authors.lastname: Conti
authors.forename: James A
authors.initials: JA
authors.lastname: Hill
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D017147:Defibrillators, Implantable; D004562:Electrocardiography; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000319:Adrenergic beta-Antagonists