Biological behavior of hat-stacked carbon nanofibers in the subcutaneous tissue in rats.
The tissue response to hat-stacked carbon nanofibers (H-CNFs) was evaluated. H-CNFs were implanted in the subcutaneous tissue of rats. Histological and ultrastructural investigations were carried out by transmission electron microscopy. Although many macrophages and foreign body giant cells were seen around H-CNFs, no severe inflammatory response such as necrosis was observed. Some H-CNFs were observed in lysosomal vacuoles of phagocytes. These results showed that H-CNFs were not strong prophlogistic substances and were englobed in vivo.
Yokoyama
Atsuro
A
Graduate School of Dental Medicine, Hokkaido University, Japan. yokoyama@den.hokudai.ac.jp
Sato
Yoshinori
Y
Nodasaka
Yoshinobu
Y
Yamamoto
Satoru
S
Kawasaki
Takao
T
Shindoh
Masanobu
M
Kohgo
Takao
T
Akasaka
Tsukasa
T
Uo
Motohiro
M
Watari
Fumio
F
Tohji
Kazuyuki
K
D000818:Animals; D002244:Carbon / Q000737:chemistry* / Q000633:toxicity; D008297:Male; D008422:Materials Testing; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry* / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D040521:Subcutaneous Tissue / Q000648:ultrastructure*
D002244:Carbon