title: Antitubercular agents. Part 1: synthesis of phthalimido- and naphthalimido-linked phenazines as new prototype antitubercular agents.
abstract: The preparation and antitubercular properties of a series of phthalimido- and naphthalimido-linked phenazines are described. Some of these new compounds inhibited the growth of Mycobacterium tuberculosis ATCC 27294, Mycobacterium avium ATCC 49601, Mycobacterium intracellulare ATCC 13950 and some clinical isolates.
authors.affiliation: Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Hyderabad 500007, India. ahmedkamal@iict.res.in
authors.forename: Ahmed
authors.initials: A
authors.lastname: Kamal
authors.forename: A
authors.initials: A
authors.lastname: Hari Babu
authors.forename: A
authors.initials: A
authors.lastname: Venkata Ramana
authors.forename: Rakesh
authors.initials: R
authors.lastname: Sinha
authors.forename: J S
authors.initials: JS
authors.lastname: Yadav
authors.forename: Sudarshan K
authors.initials: SK
authors.lastname: Arora
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007094:Imides / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009162:Mycobacterium avium / Q000187:drug effects; D015269:Mycobacterium avium Complex / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009281:Naphthalenes / Q000737:chemistry*; D010619:Phenazines / Q000138:chemical synthesis* / Q000494:pharmacology; D010797:Phthalimides / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000995:Antitubercular Agents; D007094:Imides; D009281:Naphthalenes; D010619:Phenazines; D010797:Phthalimides