Anti-metastatic effects of curcusone B, a diterpene from Jatropha curcas.
A new approach to cancer therapy in recent years has been to target the metastatic process. The anti-metastatic potential of curcusone B, a diterpene isolated from Jatropha curcas Linn. (Euphorbiaceae), a herbal plant that has been used in traditional folk medicine in many tropical countries, was investigated against 4 human cancer cell lines. Treatment with non-cytotoxic doses of curcusone B resulted in a strong reduction of in vitro invasion, motility and secretion of matrix-metalloproteinases (MMP) of the cancer cells, whereas the ability to adhere to a Matrigel-coated surface was variably sensitive to curcusone B treatment. Curcusone B, thus, effectively suppresses the metastatic processes at doses that are non-toxic to cells, which may be of therapeutic benefit for the treatment of metastatic cancers.
Muangman
Surin
S
Department of Biochemistry, Faculty of Science, Mahidol University, Phya Thai, Bangkok 10400, Thailand.
Thippornwong
Montri
M
Tohtong
Rutaiwan
R
D000230:Adenocarcinoma / Q000473:pathology; D002759:Adenoma, Bile Duct / Q000473:pathology; D001650:Bile Duct Neoplasms / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology; D006528:Carcinoma, Hepatocellular / Q000473:pathology; D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003094:Collagen / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D031286:Jatropha / Q000737:chemistry*; D007624:KB Cells; D007797:Laminin / Q000187:drug effects; D008113:Liver Neoplasms / Q000473:pathology; D009361:Neoplasm Invasiveness / Q000517:prevention & control; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D010946:Plants, Medicinal; D011509:Proteoglycans / Q000187:drug effects
D004224:Diterpenes; D004338:Drug Combinations; D007797:Laminin; D011509:Proteoglycans; C502434:curcusone B; C059485:matrigel; D003094:Collagen