title: The Campylobacter jejuni glycome.
abstract: Microbial cell surface glycans in the form of glycolipids and glycoproteins frequently play important roles in cell-cell interaction and host immune responses. Given the likely importance of these surface structures in the survival and pathogenesis of Campylobacter jejuni, a concerted effort has been made to characterise these determinants genetically and structurally since the genome was sequenced in 2000. We review the considerable progress made in characterising the Campylobacter glycome including the lipooligosaccharide (LOS), the capsule and O- and N-linked protein glycosylation systems, and speculate on the roles played by glycan surface structures in the life-cycle of C. jejuni.
authors.affiliation: Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St., London WC1E 7HT, UK.
authors.forename: Andrey V
authors.initials: AV
authors.lastname: Karlyshev
authors.forename: Julian M
authors.initials: JM
authors.lastname: Ketley
authors.forename: Brendan W
authors.initials: BW
authors.lastname: Wren
mesh_terms: D000818:Animals; D016667:Bacterial Capsules / Q000096:biosynthesis*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D016123:Campylobacter jejuni / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D002240:Carbohydrate Sequence; D006031:Glycosylation; D006801:Humans; D008070:Lipopolysaccharides / Q000096:biosynthesis*; D008969:Molecular Sequence Data
chemical_list: D001426:Bacterial Proteins; D008070:Lipopolysaccharides; C023023:lipid-linked oligosaccharides