title: Angiotropic B-cell lymphoma with telangiectasia, accompanied by panniculitic formation.
abstract: A 67-year-old female presented with diffuse edema, generalized telangiectasia, and indurated skin plaques. Histopathological findings of the skin lesion included CD45+/CD79+/CD20+ large lymphoma cells that filled the vascular lumina and infiltrated the subcutaneous tissues with panniculitic formations. Three cycles of a CHOP (cyclophosphamide, adriamycin, vincristine, and prednisolone) chemotherapy regimen resolved the skin manifestations. After five cycles of CHOP, however, she developed dementia-like symptoms. Three cycles of additional intrathecal chemotherapy (methotrexate, cytarabine and prednisolone) did not improve the neurological symptoms.
authors.affiliation: Department of Dermatology, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakaecho, Itabashi-ku, Tokyo 173-0015, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Nishiyama
authors.forename: Ryoji
authors.initials: R
authors.lastname: Tanei
authors.forename: Takashi
authors.initials: T
authors.lastname: Motegi
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Ohta
authors.forename: Motoji
authors.initials: M
authors.lastname: Sawabe
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004317:Doxorubicin / Q000008:administration & dosage; D004487:Edema / Q000209:etiology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016393:Lymphoma, B-Cell / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D015434:Panniculitis / Q000209:etiology; D011241:Prednisone / Q000008:administration & dosage; D013684:Telangiectasis / Q000209:etiology; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone