title: Atypical presentation of sinus histiocytosis with massive lymphadenopathy as an epidural spinal cord tumor: a case presentation and literature review.
abstract: Sinus histiocytosis with massive lymphadenopathy is a benign lymphoproliferative disorder growing in frequency as awareness of the disease increases. Also known as Rosai-Dorfman disease, it typically presents as painless cervical lymphadenopathy with fever and malaise. A review of the literature reveals approximately 400 cases of extranodal involvement and approximately 44 cases of central nervous system involvement. Less than 10 of the reported central nervous system tumors have presented as an epidural spinal cord tumor. The authors describe the case of a 29-year-old woman with progressive paraplegia and leg pain. Magnetic resonance imaging of the thoracic spine revealed a tumor mass from T5 to T9. The tumor was resected, and the spinal column was stabilized with pedicle screw fixation and fusion. Postoperative treatment was initiated with radiation and physical rehabilitation. The following is a case report with literature review of the entity.
authors.affiliation: Pikeville College School of Osteopathic Medicine, Pikeville, Kentucky, USA. hargett1@pc.edu
authors.forename: Christopher
authors.initials: C
authors.lastname: Hargett
authors.forename: Timothy
authors.initials: T
authors.lastname: Bassett
mesh_terms: D000328:Adult; D019299:Decompression, Surgical; D015174:Epidural Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D004824:Epidural Space / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D005260:Female; D015618:Histiocytosis, Sinus / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007796:Laminectomy; D008279:Magnetic Resonance Imaging; D010146:Pain / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D010264:Paraplegia / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D010291:Paresis / Q000503:physiopathology; D011859:Radiography; D012008:Recurrence; D013120:Spinal Cord Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D013123:Spinal Fusion; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome