title: Pharmacokinetic profile of tigecycline in serum and skin blister fluid of healthy subjects after multiple intravenous administrations.
abstract: The pharmacokinetics of tigecycline, when given as a 100-mg loading dose followed by 50 mg every 12 h, were determined in serum and blister fluid. The peak tigecycline concentration and half-life in serum were greater than those in blister fluid. Tigecycline penetrates into blister fluid well, with a mean penetration rate of 74%.
authors.affiliation: Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut 06102, USA.
authors.forename: Heather K
authors.initials: HK
authors.lastname: Sun
authors.forename: Christine T
authors.initials: CT
authors.lastname: Ong
authors.forename: Ambreen
authors.initials: A
authors.lastname: Umer
authors.forename: Dawn
authors.initials: D
authors.lastname: Harper
authors.forename: Steven
authors.initials: S
authors.lastname: Troy
authors.forename: Charles H
authors.initials: CH
authors.lastname: Nightingale
authors.forename: David P
authors.initials: DP
authors.lastname: Nicolau
mesh_terms: D000328:Adult; D001768:Blister / Q000378:metabolism*; D001826:Body Fluids / Q000378:metabolism; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008911:Minocycline / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood* / Q000493:pharmacokinetics*; D012867:Skin; D000078304:Tigecycline
chemical_list: D000078304:Tigecycline; D008911:Minocycline