[Metabolic acidosis in patients with chronic kidney diseases: why and when to treat it?].
Metabolic acidosis is a common complication in patients with advanced chronic renal diseases and dialytic treatments are unable to correct it completely. In hemodialysis (HD) patients, severe metabolic acidosis is associated with an increased risk of death. Evidence from several experimental studies suggests that even mild metabolic acidosis is associated with systemic effects. Acidosis is implicated in endocrine changes and has negative repercussions on bone and protein metabolism. In addition, recent observations suggest that acidosis triggers inflammation and accelerates the progression of chronic kidney diseases. As a contradictory finding, acidosis can reduce circulating leptin. Clinical studies on the nutritional effects of metabolic acidosis correction have shown mildly favorable effects. Taking into account the systemic effects of metabolic acidosis it is suggested that even mild metabolic acidosis is corrected. However, the new findings concerning the systemic effects of acidosis must be evaluated in controlled trials.
Sofia
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Divisione di Nefrologia, Dipartimento di Medicina Interna, Universita' di Genova - Italy.
Cappelli
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Valli
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Garibotto
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D000138:Acidosis / Q000209:etiology* / Q000628:therapy*; D000141:Acidosis, Renal Tubular / Q000150:complications / Q000209:etiology; D018450:Disease Progression; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000150:complications*; D020738:Leptin / Q000378:metabolism
D020738:Leptin