COX-2 inhibitor induced anuric renal failure in a previously healthy young woman.
Side effects of nonsteroidal anti-inflammatory drugs (NSAIDs) most commonly affect the gastrointestinal tract and the kidney. The recent release of selective cyclooxygenase-2 (COX-2) inhibitors has been associated with a decrease in adverse gastrointestinal effects. However, the nephrotoxic potential of these drugs still remains controversial. Here, we report the case of a previously healthy woman with reversible acute renal failure associated with eight days of anuria following the administration of valdecoxib, a newly released selective cyclooxygenase-2 inhibitor, during an episode of acute febrile pyelonephritis. We suggest that selective COX-2 inhibitors should not be used in patients with volume contraction and underlying renal disease.
Mühlfeld
A S
AS
Division of Nephrology and Immunology, University of Aachen, Germany.
Floege
J
J
D000208:Acute Disease; D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D001002:Anuria / Q000139:chemically induced*; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007555:Isoxazoles / Q000009:adverse effects*; D011704:Pyelonephritis / Q000188:drug therapy; D013449:Sulfonamides / Q000009:adverse effects*; D000096926:Benzenesulfonamides
D016861:Cyclooxygenase Inhibitors; D007555:Isoxazoles; D013449:Sulfonamides; C406224:valdecoxib; D000096926:Benzenesulfonamides