title: [Bronchiolitis treated with mechanical ventilation: prognosis factors and outcome in a series of 135 children].
abstract: Viral bronchiolitis is usually associated with favorable outcome as regard to mortality. Only few studies reported severe bronchiolitis requiring mechanical ventilation, and respiratory outcome is not well described.
  
  
  METHODS
  Therefore, we conducted a retrospective study in a series of 135 children admitted in a single Pediatric Intensive Care Unit (PICU) over a four year period (1994-1998). All of them were admitted for viral bronchiolitis requiring mechanical ventilation.
  
  
  RESULTS
  At admission, 83% of them were less than three months old. Prematurity at birth was present in 33,3%. Mortality was observed in four cases (2,9%), all premature babies with mechanical ventilation at birth. Univariate analysis showed as main factors associated to mortality: prematurity (P =0,056) and acute respiratory distress syndrome (P =0,017). Childhood asthma was observed in 40,4% of children without any associated factor wether at birth or in PICU related to such outcome.
  
  
  CONCLUSIONS
  Bronchiolitis associated with mechanical ventilation is particularly observed in very young babies and prematurity is the main factor associated to mortality. Mechanical ventilation seems not to be associated with unfavorable respiratory outcome. Considering physiology and population, non invasive ventilation could be an effective alternative of mechanical ventilation.
authors.affiliation: Service de réanimation pédiatrique, hôpital Bicêtre, assistance publique-hôpitaux de Paris, 78 rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre, France. laurent.chevret@bct.ap-hop-paris.fr
authors.forename: L
authors.initials: L
authors.lastname: Chevret
authors.forename: B
authors.initials: B
authors.lastname: Mbieleu
authors.forename: S
authors.initials: S
authors.lastname: Essouri
authors.forename: P
authors.initials: P
authors.lastname: Durand
authors.forename: S
authors.initials: S
authors.lastname: Chevret
authors.forename: D
authors.initials: D
authors.lastname: Devictor
mesh_terms: D001988:Bronchiolitis / Q000628:therapy*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011379:Prognosis; D012121:Respiration, Artificial; D012189:Retrospective Studies