title: Synthesis of beta-amino-alpha-hydroxy esters and beta-amino-alpha-azido ester by Sharpless asymmetric aminohydroxylation, byproducts analysis.
abstract: [reaction: see text] Synthesis of enantiomerically pure beta-amino-alpha-hydroxy esters (1, 2) and beta-amino-alpha-azido ester (3) using Sharpless AA as a key step is described. A hitherto unreported side reaction, the oxidation of the beta-hydroxy-alpha-amino ester (5) into the alpha,alpha-di-tert-butyloxycarbamoyl-beta-ketoester (8) under AA conditions, is documented.
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette Cedex, France.
authors.forename: Zuosheng
authors.initials: Z
authors.lastname: Liu
authors.forename: Nianchun
authors.initials: N
authors.lastname: Ma
authors.forename: Yanxing
authors.initials: Y
authors.lastname: Jia
authors.forename: Michèle
authors.initials: M
authors.lastname: Bois-Choussy
authors.forename: Adriano
authors.initials: A
authors.lastname: Malabarba
authors.forename: Jieping
authors.initials: J
authors.lastname: Zhu