Effect of exogenous administration of nerve growth factor in the retina of rats with inherited retinitis pigmentosa.
NGF is implicated in retinal damage regression. To study whether this is a direct effect or an effect mediated by NGF on other endogenous biological mediators, we investigated the effect of exogenous administration of NGF in RCS rats affected by retinitis pigmentosa. We found that NGF administration exerts a rescue effect on photoreceptors in this animal model. NGF injection enhances brain-derived neurotrophic factor, beta-fibroblast growth factor, transforming growth factor-beta, vascular endothelial factor and neuropeptide-Y. This suggests that NGF has an effect on RCS rat retina, probably also through the stimulation of other biological mediators produced and released in the retina.
Lenzi
Laura
L
Institute of Neurobiology and Molecular Medicine, Neurobiology Section, CNR, Viale Marx 43/15, 00137 Rome, Italy.
Coassin
Marco
M
Lambiase
Alessandro
A
Bonini
Stefano
S
Amendola
Tiziana
T
Aloe
Luigi
L
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000032:analysis; D005136:Eye Proteins / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000032:analysis; D009339:Needles; D020932:Nerve Growth Factor / Q000276:immunology / Q000494:pharmacology*; D009478:Neuropeptide Y / Q000032:analysis; D010786:Photoreceptor Cells / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D020917:Receptor, trkA / Q000032:analysis; D012160:Retina / Q000187:drug effects* / Q000378:metabolism; D012171:Retinal Vessels / Q000187:drug effects; D012174:Retinitis Pigmentosa / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000032:analysis; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis
D019208:Brain-Derived Neurotrophic Factor; D005136:Eye Proteins; D009478:Neuropeptide Y; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha; D042461:Vascular Endothelial Growth Factor A; D005346:Fibroblast Growth Factors; D020932:Nerve Growth Factor; D020917:Receptor, trkA