Cell-cycle control during development: taking it up a notch.
The signals that coordinate cellular proliferation with G1 arrest and differentiation have long been of interest. Two papers in this issue of Developmental Cell show that the conserved Hedgehog and Notch signaling pathways regulate cell division during development of the Drosophila compound eye.
Thomas
Barbara J
BJ
Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA.
D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D002454:Cell Differentiation; D049109:Cell Proliferation; D029721:Drosophila Proteins / Q000378:metabolism; D004331:Drosophila melanogaster; D053823:Hedgehog Proteins; D008565:Membrane Proteins / Q000378:metabolism; D009024:Morphogenesis; D051880:Receptors, Notch; D012160:Retina / Q000166:cytology / Q000254:growth & development*; D015398:Signal Transduction / Q000502:physiology
D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D008565:Membrane Proteins; C497759:N protein, Drosophila; D051880:Receptors, Notch; C077245:hh protein, Drosophila