title: Complications associated with isotretinoin use after rhinoplasty.
abstract: BACKGROUND
  This study aimed to evaluate the association between the postoperative use of isotretinoin and the formation of nasal tip deformities after rhinoplasty.
  
  
  METHODS
  A retrospective study investigated a case series of patients who presented with nasal tip deformities subsequent to the use of isotretinoin after rhinoplasty. Patients who had taken isotretinoin after rhinoplasty were identified from a single surgeon's case log. Clinic charts and operative reports were reviewed. Predisposing factors and time intervals to complications were identified.
  
  
  RESULTS
  Three patients were found to have undergone isotretinoin therapy after rhinoplasty. Nasal tip deformities included bossa formation, asymmetry, and prominence of a composite graft. All three patients required subsequent procedures to repair soft tissue nasal tip deformities. In all three cases, isotretinoin was started within 2 years of the primary rhinoplasty. The nasal tip deformities were first observed within 6 months after isotretinoin was started.
  
  
  CONCLUSIONS
  Three cases are described in which postoperative use of isotretinoin was associated with nasal tip deformities after rhinoplasty. Further studies are needed to investigate this possible causative relationship and to describe the risks involved.
authors.affiliation: Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
authors.forename: Brian C
authors.initials: BC
authors.lastname: Allen
authors.forename: John S
authors.initials: JS
authors.lastname: Rhee
mesh_terms: D000293:Adolescent; D000328:Adult; D003879:Dermatologic Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects*; D008297:Male; D009300:Nasal Septum / Q000601:surgery; D009666:Nose / Q000601:surgery*; D011184:Postoperative Period; D012189:Retrospective Studies; D012225:Rhinoplasty / Q000379:methods*
chemical_list: D003879:Dermatologic Agents; D015474:Isotretinoin