title: Nonopsonic phagocytosis of erythrocytes infected with ring-stage Plasmodium falciparum.
abstract: Ring-stage parasitized erythrocytes (RPEs) were demonstrated to interact with effector cells of the innate immune system. With receptor blockade studies and CD36-null macrophages, human and murine macrophages were shown to phagocytose RPEs through the pattern recognition receptor CD36. These in vitro data implicate scavenger receptors in the clearance of RPEs.
authors.affiliation: Department of Medicine, University of Toronto, Ontario, Canada.
authors.forename: Kodjo
authors.initials: K
authors.lastname: Ayi
authors.forename: Samir N
authors.initials: SN
authors.lastname: Patel
authors.forename: Lena
authors.initials: L
authors.lastname: Serghides
authors.forename: Todd G
authors.initials: TG
authors.lastname: Smith
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Kain
mesh_terms: D000818:Animals; D018955:CD36 Antigens / Q000502:physiology*; D004912:Erythrocytes / Q000469:parasitology*; D006801:Humans; D007113:Immunity, Innate; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010587:Phagocytosis; D010963:Plasmodium falciparum / Q000276:immunology*; D015800:Protozoan Proteins / Q000502:physiology
chemical_list: D018955:CD36 Antigens; D015800:Protozoan Proteins; C085731:erythrocyte membrane protein 1, Plasmodium falciparum