Relation of serum uric acid with metabolic risk factors in asymptomatic middle-aged Brazilian men.
This study in 352 asymptomatic middle-aged Brazilian men demonstrated that serum uric acid increases linearly with an increasing number (0 to >/=3) of metabolic risk factors (5.78 +/- 1.1, 6.14 +/- 1.0, 6.27 +/- 1.1, and 6.79 +/- 1.3, p <0.001). In patients who had >/=3 metabolic risk factors, there was a higher prevalence of serum uric acid in the highest quartile (7.2 to 10.3 mg/dl) than in the lowest quartile (2.6 to 5.4 mg/dl, 35% vs 12%, p <0.001). Mean serum levels of uric acid were higher in those who had an abnormal ratio of >/=3 for triglyceride to high-density lipoprotein (suggesting insulin resistance) than in those who had a normal ratio (6.6 +/- 1.2 vs 5.87 +/- 1 mg/dl, p <0.001).
Desai
Milind Y
MY
Ciccarone Preventive Cardiology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Santos
Raul D
RD
Dalal
Darshan
D
Carvalho
Jose A M
JA
Martin
Don R
DR
Flynn
John A
JA
Nasir
Khurram
K
Blumenthal
Roger S
RS
D000328:Adult; D000367:Age Factors; D001938:Brazil; D002318:Cardiovascular Diseases / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D006801:Humans; D008297:Male; D008659:Metabolic Diseases / Q000097:blood*; D008875:Middle Aged; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood*
D008076:Cholesterol, HDL; D014280:Triglycerides; D014527:Uric Acid