title: Positive correlation between sialyl Lewis X expression and pathologic findings in renal cell carcinoma.
abstract: BACKGROUND
  Interaction between tumor cells and endothelium plays a major role in cancer invasion and metastasis. Among various cell adhesion molecules, the cognate interaction between sialyl Lewis antigen expressed in the tumor cell surface and E-selectin expressed on endothelial cells is considered to be crucial for the tumor cell adhesion to the endothelium.
  
  
  METHODS
  The sialyl Lewis X (sL(X)) expression in 45 specimens from renal cell carcinoma patients was examined using immunohistochemistry.
  
  
  RESULTS
  In this study, we demonstrate that the immunoreactivity for sL(X) in renal cell carcinoma specimens not only correlates with conventional histopathologic parameters but also serves as a useful indicator for the prognosis of renal cell carcinoma.
  
  
  CONCLUSIONS
  Since beneficial effect of cimetidine has been reported and ascribed to its inhibitory action on the expression of E-selectin, a ligand molecule of sialyl Lewis antigen, cimetidine may also show inhibitory effect on the tumor recurrence and metastasis of renal cell carcinoma with high level of sL(X) expression.
authors.affiliation: Department of Nephro-urology, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Tozawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Okamoto
authors.forename: Noriyasu
authors.initials: N
authors.lastname: Kawai
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: Yutaro
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Kohri
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D002292:Carcinoma, Renal Cell / Q000473:pathology*; D002927:Cimetidine / Q000627:therapeutic use; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000473:pathology*; D007983:Lewis Blood Group Antigens; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009844:Oligosaccharides / Q000032:analysis*; D000080506:Sialyl Lewis X Antigen
chemical_list: D000276:Adjuvants, Immunologic; D007983:Lewis Blood Group Antigens; D009844:Oligosaccharides; D000080506:Sialyl Lewis X Antigen; D002927:Cimetidine