title: Genetic polymorphism of CYP2C9 in a Vietnamese Kinh population.
abstract: Cytochrome P450 2C9 (CYP2C9) shows genetic polymorphism with high interethnic variation, but no report has addressed the genetic polymorphism in the Vietnamese population. In the present study, the distribution of 2 common allelic variations of CYP2C9 was investigated in Vietnamese Kinh population, a major ethnic group in Vietnam. Genomic DNA from 157 Vietnamese subjects was amplified by polymerase chain reaction, and the presence of CYP2C9*2 and CYP2C9*3 allelic variants was determined by pyrosequencing. Among 157 Vietnamese subjects, no subject with the CYP2C9*2 allele was detected, but 7 subjects were heterozygous for the CYP2C9*3 allele. The allele frequency of CYP2C9*3 was 2.2% in the Vietnamese Kinh population. This genotype distribution was well correlated with previous reports suggesting no occurrence of CYP2C9*2 in Asians. These results suggest that CYP2C9*2 may be absent in Vietnamese Kinh population and that CYP2C9*3 is major allelic variant that causes interindividual variation of drug responses to CYP2C9 substrate drugs in the Vietnamese Kinh population.
authors.affiliation: Pharmacogenomics Research Center and Department of Pharmacology, Inje University College of Medicine, 633-165 Gaegum-dong, Jin-gu, Busan 614-735 Korea.
authors.forename: Sang Seop
authors.initials: SS
authors.lastname: Lee
authors.forename: Kang-Mi
authors.initials: KM
authors.lastname: Kim
authors.forename: Huong
authors.initials: H
authors.lastname: Thi-Le
authors.forename: Sung-Su
authors.initials: SS
authors.lastname: Yea
authors.forename: In-June
authors.initials: IJ
authors.lastname: Cha
authors.forename: Jae-Gook
authors.initials: JG
authors.lastname: Shin
mesh_terms: D000483:Alleles; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics* / Q000378:metabolism; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D065729:Cytochrome P-450 CYP2C9; D006580:Genetic Carrier Screening / Q000379:methods; D006801:Humans; D010597:Pharmacogenetics; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic / Q000235:genetics*; D014744:Vietnam / Q000208:ethnology
chemical_list: C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D001189:Aryl Hydrocarbon Hydroxylases