title: A case of gastric hyperplastic polyp with malignant transformation.
abstract: In this paper we report a case of hyperplastic polyp with malignant transformation. The patient was followed up by annual radiographic and endoscopic examination during 9 years. The first gastroscopy revealed a semi-pedunculated polyp beneath the esophageal-cardiac junction, 1.5cm in diameter and slightly reddish with smooth surface. Histological findings showed a hyperplastic polyp. There was slight change in size, but no change in histological examination of the lesion during the follow-up. In 1996, the biopsy specimen showed an atypical epithelium and the polyp was removed by snear polypectomy. A microscopic examination revealed a well-differentiated adenocarcinoma. Immunohistochemically, p53 and Ki-67 immunostaining showed positive in the carcinoma portion of the adenocarcinoma bearing a hyperplastic polyp in the stomach.
authors.affiliation: Department of Medical Biochemistry Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. sibahara-koutarou@kouseikan.saga.sag.jp
authors.forename: Kotaro
authors.initials: K
authors.lastname: Shibahara
authors.forename: Yukiaki
authors.initials: Y
authors.lastname: Haraguchi
authors.forename: Isamu
authors.initials: I
authors.lastname: Sasaki
authors.forename: Hideyasu
authors.initials: H
authors.lastname: Kiyonari
authors.forename: Tatuhiro
authors.initials: T
authors.lastname: Oishi
authors.forename: Akinori
authors.initials: A
authors.lastname: Iwashita
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Maehara
authors.forename: Keizo
authors.initials: K
authors.lastname: Sugimachi
mesh_terms: D000368:Aged; D002471:Cell Transformation, Neoplastic; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D011127:Polyps / Q000473:pathology*; D013270:Stomach / Q000473:pathology*; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53