title: Hepatic steatosis in transgenic mice overexpressing human histone deacetylase 1.
abstract: It is generally thought that histone deacetylases (HDACs) play important roles in the transcriptional regulation of genes. However, little information is available concerning the specific functions of individual HDACs in disease states. In this study, two transgenic mice lines were established which harbored the human HDAC1 gene. Overexpressed HDAC1 was detected in the nuclei of transgenic liver cells, and HDAC1 enzymatic activity was significantly higher in the transgenic mice than in control littermates. The HDAC1 transgenic mice exhibited a high incidence of hepatic steatosis and nuclear pleomorphism. Molecular studies showed that HDAC1 may contribute to nuclear pleomorphism through the p53/p21 signaling pathway.
authors.affiliation: Laboratory of Human Genomics, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Republic of Korea.
authors.forename: Ai-Guo
authors.initials: AG
authors.lastname: Wang
authors.forename: Sang-Beom
authors.initials: SB
authors.lastname: Seo
authors.forename: Hyung-Bae
authors.initials: HB
authors.lastname: Moon
authors.forename: Hye-Jun
authors.initials: HJ
authors.lastname: Shin
authors.forename: Dong Hoon
authors.initials: DH
authors.lastname: Kim
authors.forename: Jin-Man
authors.initials: JM
authors.lastname: Kim
authors.forename: Tae-Hoon
authors.initials: TH
authors.lastname: Lee
authors.forename: Ho Jeong
authors.initials: HJ
authors.lastname: Kwon
authors.forename: Dae-Yeul
authors.initials: DY
authors.lastname: Yu
authors.forename: Dong-Seok
authors.initials: DS
authors.lastname: Lee
mesh_terms: D000818:Animals; D001483:Base Sequence; D018797:Cell Cycle Proteins / Q000235:genetics; D050759:Cyclin-Dependent Kinase Inhibitor p21; D017931:DNA Primers; D005234:Fatty Liver / Q000201:enzymology*; D016158:Genes, p53; D006655:Histone Deacetylases / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic
chemical_list: C493956:CDKN1A protein, human; C493957:Cdkn1a protein, mouse; D018797:Cell Cycle Proteins; D050759:Cyclin-Dependent Kinase Inhibitor p21; D017931:DNA Primers; D006655:Histone Deacetylases