Severe topiramate-associated hyperthermia resulting in persistent neurological dysfunction.
Topiramate has recently been reported to cause hyperthermia as a result of oligohydrosis, primarily in pediatric patients. All cases reported to date were clinically mild, without permanent systemic or neurologic dysfunction. We report a case of severe hyperthermia and subsequent ataxia and tremor in an adult treated with topiramate. To our knowledge, this is the first case of topiramate-associated hyperthermia to result in residual cerebellar and cognitive dysfunction.
Galicia
Sharon C
SC
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA.
Lewis
Steven L
SL
Metman
Leo Verhagen
LV
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D005334:Fever / Q000209:etiology*; D005632:Fructose / Q000009:adverse effects* / Q000031:analogs & derivatives*; D006801:Humans; D007007:Hypohidrosis; D008297:Male; D012640:Seizures / Q000188:drug therapy; D000077236:Topiramate
D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose