title: Accumulation of fenvalerate and related changes in lactate and succinate dehydrogenases activity in functionally different tissues of the freshwater fish, Cirrhinus mrigala (Hamilton).
abstract: Acute toxicity (LC50) of fenvalerate at 96 h to the freshwater fish Cirrhinus mrigala was 6 microg/L. The accumulation of fenvalerate at different exposure periods (1, 2, 3, 4 d) on different tissues, namely gill, muscle, and liver, was first confirmed by thin layer chromatography and quantified with gas liquid chromatography. Gill accounted for the maximum accumulation of fenvalerate followed by muscle and liver. Enzyme assay indicated an increased activity of lactate dehydrogenase, whereas the activity of succinate dehydrogenase decreased continuously up to 96 h in all selected tissues. The alteration in the activity of these enzymes in the fish treated with fenvalerate might be due to the severe cellular damage leading to the release of these enzymes and impaired carbohydrate and protein metabolism.
authors.affiliation: Karnataka University's Research Laboratory, Department of Zoology, Toxicology Division, Karnataka Science College Dharwad-580 001 Karnataka, India. mushigerisadanand@Rediffmail.com
authors.forename: S B
authors.initials: SB
authors.lastname: Mushigeri
authors.forename: M
authors.initials: M
authors.lastname: David
mesh_terms: D000818:Animals; D003530:Cyprinidae; D004781:Environmental Exposure / Q000009:adverse effects; D004789:Enzyme Activation / Q000502:physiology; D005618:Fresh Water / Q000032:analysis; D019344:Lactic Acid / Q000032:analysis / Q000378:metabolism*; D009570:Nitriles / Q000032:analysis / Q000378:metabolism* / Q000633:toxicity*; D011722:Pyrethrins / Q000032:analysis / Q000378:metabolism* / Q000633:toxicity*; D013385:Succinate Dehydrogenase / Q000032:analysis / Q000378:metabolism*; D014018:Tissue Distribution / Q000502:physiology
chemical_list: D009570:Nitriles; D011722:Pyrethrins; D019344:Lactic Acid; D013385:Succinate Dehydrogenase; C017690:fenvalerate