Effects of ischemia-reperfusion on NMDA receptor subunits 2a and 2b level in rat hippocampus.
The authors investigated the effects of ischemia and reperfusion on the N-methyl-D-aspartate receptor (NMDAR) subunits 2A and 2B concentration in rat hippocampus. At the protein level, significant increase in the amounts of NMDAR 2A and NMIDAR 2B in the rat hippocampus was observed at 1 h after reperfusion compared with control group. These results suggested that the alteration in hippocampal NMDAR2 subunit concentrations after ischemia-reperfusion might be invovlved in cognitive dysfunction and excitotoxicity.
Sutcu
Recep
R
Department of Biochemistry, Medical Faculty Suleyman Demirel University Ispacta Turkey.
Altuntas
Irfan
I
Eroglu
Erol
E
Delibas
Namik
N
D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism*; D003072:Cognition Disorders / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D009498:Neurotoxins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D015427:Reperfusion Injury / Q000378:metabolism*
D009498:Neurotoxins; D016194:Receptors, N-Methyl-D-Aspartate; C121001:NR2B NMDA receptor