Targeting cerebral arteries for gene therapy.
After the steady progress towards application of gene therapy to cerebral arterial diseases, several applications, including modification of gene expression in cerebral arteries, are now feasible. There are several possible targets for cerebrovascular gene therapy, and numerous studies have tested gene therapy strategies in animal models of cerebrovascular disorders. However, some major obstacles, especially issues of safety, must be overcome before clinical use in humans. Gene therapy for cerebral arterial diseases is still in its infancy, and many basic and preclinical studies are yet to be done in order to develop effective and safe techniques.
Watanabe
Yoshimasa
Y
Department of Internal Medicine, Cardiovascular Center, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA.
Heistad
Donald D
DD
D000818:Animals; D002539:Cerebral Arterial Diseases / Q000235:genetics* / Q000628:therapy*; D018390:Gene Targeting / Q000379:methods*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D006133:Growth Substances / Q000235:genetics / Q000627:therapeutic use; D006801:Humans; D018919:Neovascularization, Physiologic / Q000235:genetics*
D006133:Growth Substances