[Enhancement of thrombolytic activities of Carthamus tinctorius processed with fermentation with a bacillus sp. C2-13].
A processing method to enhance thrombolytic effect of Carthamus tinctorius using a fermentation technology with bacillus sp. C2-13 was investigated. The fibrinolysis and anticoagulation activity of thrombolytic extracts from an optimized fermentation process was studied using a carrageenan induced mice model. The fermented extracts resulted in significantly better thrombolytic activity, suggesting that the process was promising for use in the study and preparation of nature medicines.
He
Chen
C
College of Life Science, Sichuan University, Chengdu 610064, China.
Jin-Zhao
Feng
Zhi-hua
ZH
Bai
Jia-feng
JF
Tian
Tian-li
TL
Zhang
Xing-yu
XY
Sun
Qi-ling
QL
D000818:Animals; D001407:Bacillus; D031187:Carthamus tinctorius / Q000737:chemistry* / Q000382:microbiology; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D005285:Fermentation; D005342:Fibrinolysis / Q000187:drug effects*; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D051381:Rats; D017207:Rats, Sprague-Dawley; D013918:Thrombin Time
D004365:Drugs, Chinese Herbal; D005343:Fibrinolytic Agents