Genetic polymorphism of CYP2C9 in a Vietnamese Kinh population.
Cytochrome P450 2C9 (CYP2C9) shows genetic polymorphism with high interethnic variation, but no report has addressed the genetic polymorphism in the Vietnamese population. In the present study, the distribution of 2 common allelic variations of CYP2C9 was investigated in Vietnamese Kinh population, a major ethnic group in Vietnam. Genomic DNA from 157 Vietnamese subjects was amplified by polymerase chain reaction, and the presence of CYP2C9*2 and CYP2C9*3 allelic variants was determined by pyrosequencing. Among 157 Vietnamese subjects, no subject with the CYP2C9*2 allele was detected, but 7 subjects were heterozygous for the CYP2C9*3 allele. The allele frequency of CYP2C9*3 was 2.2% in the Vietnamese Kinh population. This genotype distribution was well correlated with previous reports suggesting no occurrence of CYP2C9*2 in Asians. These results suggest that CYP2C9*2 may be absent in Vietnamese Kinh population and that CYP2C9*3 is major allelic variant that causes interindividual variation of drug responses to CYP2C9 substrate drugs in the Vietnamese Kinh population.
Lee
Sang Seop
SS
Pharmacogenomics Research Center and Department of Pharmacology, Inje University College of Medicine, 633-165 Gaegum-dong, Jin-gu, Busan 614-735 Korea.
Kim
Kang-Mi
KM
Thi-Le
Huong
H
Yea
Sung-Su
SS
Cha
In-June
IJ
Shin
Jae-Gook
JG
D000483:Alleles; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics* / Q000378:metabolism; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D065729:Cytochrome P-450 CYP2C9; D006580:Genetic Carrier Screening / Q000379:methods; D006801:Humans; D010597:Pharmacogenetics; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic / Q000235:genetics*; D014744:Vietnam / Q000208:ethnology
C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D001189:Aryl Hydrocarbon Hydroxylases