Antifungal activity of flocculosin, a novel glycolipid isolated from Pseudozyma flocculosa.
Flocculosin, a glycolipid isolated from the yeast-like fungus Pseudozyma flocculosa, was investigated for in vitro antifungal activity. The compound displayed antifungal properties against several pathogenic yeasts. Synergistic activity was observed between flocculosin and amphotericin B, and no significant cytotoxicity was demonstrated when tested against human cell lines.
Mimee
Benjamin
B
Centre de Recherche en Horticulture, Université Laval, Québec, Canada G1K 7P4.
Labbé
Caroline
C
Pelletier
René
R
Bélanger
Richard R
RR
D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000378:metabolism / Q000494:pharmacology*; D002475:Cellobiose / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000494:pharmacology*; D004357:Drug Synergism; D005658:Fungi / Q000187:drug effects*; D006017:Glycolipids / Q000096:biosynthesis / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000382:microbiology; D014587:Ustilaginales / Q000378:metabolism*
C476096:2-(2',4'-diacetoxy-5'-carboxypentanoyl)octadecylcellobioside; D000935:Antifungal Agents; D006017:Glycolipids; D002475:Cellobiose; D000666:Amphotericin B