title: Polymorphisms of caprine PrP gene detected in Japan.
abstract: Polymorphism of the PrP gene is a primary factor influencing susceptibility and incubation period in natural and experimental scrapie in sheep and goats. Polymorphisms of the caprine PrP gene in Japan were examined in 118 goats. Eight allelic variants and 19 genotypes were obtained. Amino acid polymorphisms were observed at 7 codons: 102, 142, 143, 240, 127, 146 and 211 (the latter 3 are novel polymorphisms). The polymorphisms at codons 142M and 143R, which are associated with the resistance to scrapie, were relatively rare in the present study. Thus, the present results provide information about the caprine PrP gene that may be useful for assessing the risk of goat scrapie.
authors.affiliation: Laboratory of Veterinary Public Health, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan.
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Kurosaki
authors.forename: Naotaka
authors.initials: N
authors.lastname: Ishiguro
authors.forename: Motohiro
authors.initials: M
authors.lastname: Horiuchi
authors.forename: Morikazu
authors.initials: M
authors.lastname: Shinagawa
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D005838:Genotype; D005843:Geography; D006041:Goats / Q000235:genetics*; D007564:Japan; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D011328:Prions / Q000235:genetics*; D017422:Sequence Analysis, DNA / Q000662:veterinary
chemical_list: D011328:Prions