title: [Cutaneous-mucosal paracoccidio-domycosis: the first case diagnosed in French Guiana].
abstract: BACKGROUND
  Paracoccidio-domycosisis a deep mycosis due to a dimorphic fungus:Paracoccidioides brasiliensis. The principle endemic country is Brazil. We describe the first case of paracoccidio-domycosis, in its cutaneous-mucosal form, diagnosed in French Guiana.
  
  
  METHODS
  A 20 year-old Brazilian man, having mover to French Guiana a few months earlier, presented with multiple disseminated cutaneous lesions, predominating on the face, and composed of multiple nodules and two ulcerations. The clinical examination also revealed voluminous superficial lymph nodes and ulcerations of the pharynx and larynx. Direct examination, anatomopathology and culture of cutaneous biopsies revealed specific images of Paracoccidioides brasiliensis. HIV serology was negative. Treatment combining cotrimoxazole and itraconazole eliminated the lesions in one month.
  
  
  CONCLUSIONS
  Because the patient had just moved to Guiana, this observation probably corresponded to an imported disease. The principle differential diagnosis was leishmaniosis.
authors.affiliation: Service de Dermatologie, Centre Hospitalier, Cayenne, Guyane Française.
authors.forename: F
authors.initials: F
authors.lastname: Sarazin
authors.forename: D
authors.initials: D
authors.lastname: Sainte-Marie
authors.forename: M
authors.initials: M
authors.lastname: Demar
authors.forename: C
authors.initials: C
authors.lastname: Aznar
authors.forename: J
authors.initials: J
authors.lastname: Sarrouy
authors.forename: R
authors.initials: R
authors.lastname: Pradinaud
authors.forename: B
authors.initials: B
authors.lastname: Carme
authors.forename: P
authors.initials: P
authors.lastname: Couppié
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D005145:Face / Q000473:pathology; D016701:Guinea; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use*; D007896:Leishmaniasis / Q000175:diagnosis; D008297:Male; D010229:Paracoccidioidomycosis / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use*
chemical_list: D000890:Anti-Infective Agents; D000935:Antifungal Agents; D017964:Itraconazole; D015662:Trimethoprim, Sulfamethoxazole Drug Combination