title: [Expression and significance of angiopoietins in oral squamous cell carcinoma].
abstract: OBJECTIVE
  To observe the expression of angiopoietins in oral squamous cell carcinoma and relationship between the expression of angiopoietins and pathologic classification.
  
  
  METHODS
  The expression of Ang-1 and Ang-2 protein in samples from 42 oral squamous cell carcinoma and 16 oral normal mucosa were detected by immunohistochemical technique.
  
  
  RESULTS
  The expression of Ang-1 and Ang-2 was found in both oral squamous cell carcinoma and normal control. It was found Ang-1 expression alike in oral squamous cell carcinoma and control (P > 0.05). Ang-2 expressed at low level in control while strongly positive in oral squamous cell caroinoma and the level of Ang-2 expression in oral squamous cell caroinoma was related to pathologic classification (P < 0.05).
  
  
  CONCLUSIONS
  Ang-2 expression in oral squamous cell carcinoma is related to angiogenesis and pathological classification, which is probably involved in angiogenesis regulation, promotes the development and metastasis of oral squamous cell carcinoma.
authors.affiliation: Dental Department, the First Affiliated Hospital, Shanxi Medical University, Taiyuan, China.
authors.forename: Yun-xia
authors.initials: YX
authors.lastname: Wu
authors.forename: Ping
authors.initials: P
authors.lastname: Liang
authors.forename: Xin-rong
authors.initials: XR
authors.lastname: Nan
authors.forename: Yan-jun
authors.initials: YJ
authors.lastname: Jiao
authors.forename: Xiao-jun
authors.initials: XJ
authors.lastname: Sun
mesh_terms: D042683:Angiopoietin-1; D042702:Angiopoietin-2; D042682:Angiopoietins; D002294:Carcinoma, Squamous Cell; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa; D009062:Mouth Neoplasms; D009369:Neoplasms; D009389:Neovascularization, Pathologic
chemical_list: C467630:ANGPT1 protein, human; D042683:Angiopoietin-1; D042702:Angiopoietin-2; D042682:Angiopoietins