title: In vitro evaluation of tigecycline and comparative agents in 3049 clinical isolates: 2001 to 2002.
abstract: Tigecycline is the first glycylcycline antimicrobial in phase III clinical trials. This study compares the in vitro activity of tigecycline to 12 other predominately broad-spectrum antimicrobials against 3049 recent inpatient isolates from 38 clinical centers in 17 countries. The minimum concentration at which tigecycline inhibited 90% of the isolates for the entire collection, excluding Pseudomonas aeruginosa, was 1 microg/mL, including vancomycin-resistant enterococci-, extended-spectrum beta-lactamase-, and methicillin-resistant Staphylococcus aureus-resistant phenotypes.
authors.affiliation: Laboratories International for Microbiology Studies, Schaumburg, IL 60179, USA. sbouchillon@ihmainc.com
authors.forename: Samuel K
authors.initials: SK
authors.lastname: Bouchillon
authors.forename: Daryl J
authors.initials: DJ
authors.lastname: Hoban
authors.forename: Brian M
authors.initials: BM
authors.lastname: Johnson
authors.forename: Tim M
authors.initials: TM
authors.lastname: Stevens
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Dowzicky
authors.forename: David H
authors.initials: DH
authors.lastname: Wu
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Bradford
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D005060:Europe; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D008877:Middle East; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013019:South Africa; D000078304:Tigecycline
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline