title: Complaints associated with the use of antiepileptic drugs: results from a community-based study.
abstract: BACKGROUND
  Few data exist with respect to the occurrence of chronic side effects due to antiepileptic drugs (AED) in routine clinical practice.
  
  
  OBJECTIVE
  To evaluate the prevalence of subjective complaints which patients with epilepsy regard as side effects of their AED treatment in a community-based population.
  
  
  METHODS
  Cross-sectional study. Subjects were identified through the database of AED-use in the pharmacies in a suburban area in The Netherlands. Respondents completed a brief questionnaire about their epilepsy, including a checklist with 30 complaints, which are common in AED users.
  
  
  RESULTS
  We present data of 346 responding adults with treated epilepsy from a population of 107,000 adult inhabitants. Eighty percent was using monotherapy, with few patients taking new AEDs. Almost 60% of the patients reported complaints probably due to side effects in at least three domains. General CNS-related side effects were reported most often; memory problems (21.4% of the patients) and fatigue (20.3%) were dominant. Polytherapy was associated with more side effects than monotherapy. We identified differences in profiles of complaints between valproate, carbamazepine and phenytoin monotherapy. Complaints were not substantially associated with ongoing seizures or other treatment factors.
  
  
  CONCLUSIONS
  The majority of patients taking AEDs for epilepsy think they have side effects form their drugs, even when seizures were in remission and when monotherapy was used. Our findings suggest a need to improve monitoring of complaints of side effects of AEDs and to explore the feasibility of interventions aimed at reduction of such complaints in everyday clinical practice.
authors.affiliation: Department of Neurology, Hospital Gooi-Noord, P.O. Box 900, 1250 CA Laren, The Netherlands. jcarpay@gooi-noord.nl
authors.forename: J A
authors.initials: JA
authors.lastname: Carpay
authors.forename: A P
authors.initials: AP
authors.lastname: Aldenkamp
authors.forename: C A
authors.initials: CA
authors.lastname: van Donselaar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D003430:Cross-Sectional Studies; D003628:Database Management Systems / Q000706:statistics & numerical data; D003710:Demography; D018450:Disease Progression; D004827:Epilepsy / Q000188:drug therapy / Q000453:epidemiology / Q000523:psychology*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance / Q000523:psychology*; D015995:Prevalence; D011581:Psychological Tests / Q000706:statistics & numerical data; D012111:Residence Characteristics; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D016312:Treatment Refusal
chemical_list: D000927:Anticonvulsants