title: CTLA4/CT60 polymorphism is not relevant in susceptibility to autoimmune inflammatory intestinal disorders.
abstract: The aim of this work was to investigate the possible influence of the recently described CT60 A/G dimorphism of the CTLA4 (cytotoxic T-lymphocyte antigen 4) gene in the susceptibility to two different autoimmune inflammatory intestinal disorders, inflammatory bowel disease (IBD) and celiac disease. We analyzed a case-control cohort composed of 528 Spanish patients with IBD (284 with Crohn disease and 244 with ulcerative colitis) and 454 unrelated healthy individuals, and additionally a group of 90 celiac disease families. CT60 genotyping was performed with a TaqMan 5' allelic discrimination assay. After comparing patients with IBD with the control population, we found no significant deviation in the distribution of the alleles or genotypes of CTLA4/CT60 dimorphism. In addition, by means of familial and case-control analysis, no evidence for a statistically significant association was observed between CTLA4/CT60 and celiac disease susceptibility. Therefore, our results suggest that the CTLA4/CT60 polymorphism does not play a major role in inflammatory intestinal disorders.
authors.affiliation: Instituto de Parasitología y Biomedicina "López-Neyra", Granada, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Rueda
authors.forename: A
authors.initials: A
authors.lastname: Zhernakova
authors.forename: M A
authors.initials: MA
authors.lastname: López-Nevot
authors.forename: M
authors.initials: M
authors.lastname: Gomez-Garcia
authors.forename: E
authors.initials: E
authors.lastname: Ortega
authors.forename: A
authors.initials: A
authors.lastname: Piñero
authors.forename: F
authors.initials: F
authors.lastname: Correro
authors.forename: J A
authors.initials: JA
authors.lastname: Brieva
authors.forename: A
authors.initials: A
authors.lastname: Nieto
authors.forename: B P C
authors.initials: BP
authors.lastname: Koeleman
authors.forename: J
authors.initials: J
authors.lastname: Martín
mesh_terms: D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000235:genetics* / Q000276:immunology; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology; D060908:CTLA-4 Antigen; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000235:genetics / Q000276:immunology; D003424:Crohn Disease / Q000235:genetics / Q000276:immunology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics* / Q000276:immunology; D011110:Polymorphism, Genetic
chemical_list: D015703:Antigens, CD; D000943:Antigens, Differentiation; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human