title: Lateralization of pupillary light reflex parameters.
abstract: OBJECTIVE
  The aim of this study was to determine differing reactions of the left and right eyes with regard to pupillary light reflex (PLR) parameters.
  
  
  METHODS
  All together 90 healthy subjects were included. In the first test series, 34 subjects were investigated on both eyes (left eye was tested first, three tests per day and one reliability test). In the second test series, 32 subjects were studied while changing the beginning side. In the last test series, 29 subjects were investigated 12 times each within 1h (beginning side changed, without spoken advice). Infrared pupillometry was used to study pupil diameter, latency time, relative amplitude, contraction/dilation velocity, and pupil redilation time.
  
  
  RESULTS
  The study demonstrated significant differences of PLR parameters between both eyes. In contrast to the pupil diameter of the left eye the parasympathetically-dominated right eye was not influenced by vocal instructions or by changing the beginning side.
  
  
  CONCLUSIONS
  PLR parameters might indicate functional lateralization of autonomic function in the central nervous system. High sensitivity of the procedure (arousal due to spoken advice, time of day) is advantageous for various psychophysiological investigations.
  
  
  CONCLUSIONS
  Differences between both eyes might point towards cortical lateralization of central autonomic function.
authors.affiliation: Department of Psychiatry, Friedrich-Schiller-Universität Jena, Philosophenweg 3, 07743 Jena, Germany. karl-juergen.baer@med.uni-jena.de
authors.forename: Karl-Jürgen
authors.initials: KJ
authors.lastname: Bär
authors.forename: Michael Karl
authors.initials: MK
authors.lastname: Boettger
authors.forename: Silke
authors.initials: S
authors.lastname: Till
authors.forename: Julia
authors.initials: J
authors.lastname: Dolicek
authors.forename: Heinrich
authors.initials: H
authors.lastname: Sauer
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D002940:Circadian Rhythm / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation / Q000379:methods*; D012025:Reflex, Pupillary / Q000502:physiology*