Coagulation inhibitors in inflammation.
Coagulation is triggered by inflammatory mediators in a number of ways. However, to prevent unwanted clot formation, several natural anticoagulant mechanisms exist, such as the antithrombin-heparin mechanism, the tissue factor pathway inhibitor mechanism and the protein C anticoagulant pathway. This review examines the ways in which these pathways are down-regulated by inflammation, thus limiting clot formation and decreasing the natural anti-inflammatory mechanisms that these pathways possess.
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Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Howard Hughes Medical Institute, Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. charles-esmon@omrf.ouhsc.edu
D000818:Animals; D000925:Anticoagulants / Q000378:metabolism*; D017209:Apoptosis; D001777:Blood Coagulation / Q000502:physiology*; D001792:Blood Platelets / Q000166:cytology / Q000502:physiology; D005342:Fibrinolysis; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000378:metabolism* / Q000473:pathology
D000925:Anticoagulants