Role of the Rep helicase gene in homologous recombination in Neisseria gonorrhoeae.
In Escherichia coli, the Rep helicase has been implicated in replication fork progression, replication restart, homologous recombination, and DNA repair. We show that a Neisseria gonorrhoeae rep mutant is deficient in the homologous-recombination-mediated processes of DNA transformation and pilus-based colony variation but not in DNA repair.
Kline
Kimberly A
KA
Department of Microbiology and Immunology, Northwestern University Feinberg University School of Medicine, 303 East Chicago Ave., Chicago, IL 60611, USA.
Seifert
H Steven
HS
D000595:Amino Acid Sequence; D004249:DNA Damage / Q000235:genetics; D004265:DNA Helicases / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000235:genetics; D008969:Molecular Sequence Data; D009344:Neisseria gonorrhoeae / Q000235:genetics*; D011995:Recombination, Genetic; D014169:Transformation, Bacterial
D004268:DNA-Binding Proteins; D004265:DNA Helicases