title: Anterior limbic alpha-like activity: a low resolution electromagnetic tomography study with lorazepam challenge.
abstract: OBJECTIVE
  To verify findings of an independently regulated anterior limbic alpha band source.
  
  
  METHODS
  In a randomised cross-over study, the spontaneous EEG was recorded in nine healthy subjects after i.v. lorazepam or placebo. Intracerebral current densities within classical frequency bands were estimated with low resolution electromagnetic tomography [LORETA] and compared between groups with t-statistical parametric mapping [SPM[t]]. A region-of-interest [ROI] based method was used to compare frontal and occipital alpha band activity changes.
  
  
  RESULTS
  Irrespective of treatment group, local maxima of alpha band power were localised both in the occipital lobe, Brodman area [BA] 18, and in the anterior cingulate cortex [ACC], BA 32. Statistical parametric mapping showed reduced parieto-occipital, but unaltered frontal alpha band power after lorazepam. This result was confirmed by ROI-based comparison of BA 18 and BA 32.
  
  
  CONCLUSIONS
  There was an anterior limbic maximum of alpha band activity which, unlike occipital alpha, was not suppressed by lorazepam.
  
  
  CONCLUSIONS
  The well-known anterior alpha band components may originate from a narrowly circumscribed source, located in the ACC. Frontal and occipital alpha band activities appear to be independently regulated.
authors.affiliation: Department of Psychiatry III, University of Ulm, Leimgrubenweg 12, 89075 Ulm, Germany. bernhard.connemann@medizin.uni-ulm.de
authors.forename: Bernhard J
authors.initials: BJ
authors.lastname: Connemann
authors.forename: Klaus
authors.initials: K
authors.lastname: Mann
authors.forename: Christian
authors.initials: C
authors.lastname: Lange-Asschenfeldt
authors.forename: Martin
authors.initials: M
authors.lastname: Ruchsow
authors.forename: Mathias
authors.initials: M
authors.lastname: Schreckenberger
authors.forename: Peter
authors.initials: P
authors.lastname: Bartenstein
authors.forename: Gerhard
authors.initials: G
authors.lastname: Gründer
mesh_terms: D000328:Adult; D000513:Alpha Rhythm / Q000187:drug effects* / Q000379:methods; D018592:Cross-Over Studies; D004574:Electromagnetic Fields; D006801:Humans; D007275:Injections, Intravenous; D008032:Limbic System / Q000187:drug effects* / Q000502:physiology; D008140:Lorazepam / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D016037:Single-Blind Method; D018709:Statistics, Nonparametric
chemical_list: D008140:Lorazepam