Myeloperoxidase and cardiovascular disease.
Myeloperoxidase (MPO) is a leukocyte-derived enzyme that catalyzes the formation of a number of reactive oxidant species. In addition to being an integral component of the innate immune response, evidence has emerged that MPO-derived oxidants contribute to tissue damage during inflammation. MPO-catalyzed reactions have been attributed to potentially proatherogenic biological activities throughout the evolution of cardiovascular disease, including during initiation, propagation, and acute complication phases of the atherosclerotic process. As a result, MPO and its downstream inflammatory pathways represent attractive targets for both prognostication and therapeutic intervention in the prophylaxis of atherosclerotic cardiovascular disease.
Nicholls
Stephen J
SJ
Department of Cardiovascular Medicine and Center for Cardiovascular Diagnostics and Prevention, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Hazen
Stanley L
SL
D002318:Cardiovascular Diseases / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007962:Leukocytes / Q000201:enzymology; D009195:Peroxidase / Q000276:immunology* / Q000378:metabolism; D014657:Vasculitis / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology
D009195:Peroxidase