[Hodgkin's disease with bone marrow involvement. The role of positron tomography].
BACKGROUND
Hodgkin's disease with initially predominant bone marrow involvement is observed in 1% of cases.


METHODS
A case of Hodgkin's disease with massive bone marrow invasion, manifested by pancytopenia in the context of fever and alteration in general status of health, with little or non superficial peripheral lymph nodes. The bone marrow biopsy revealed extensive myelofibrosis with rare Reed-Sternberg cells.


CONCLUSIONS
This case report is inscribed within the framework of the exceptional massive bone marrow forms of Hodgkin's disease, described by Duhamel et al. in 1979. We believe that metabolic imaging with 18F-FDG positron emission tomography (PET) is a valid examination in orienting diagnosis and post-therapy assessment.
Doghmi
K
K
Service d'hématologie clinique, Hôpital d'Instruction des Armées Percy, 101 avenue Henri Barbusse, 92141 Clamart, France. kdoghmi@wanadoo.fr
Malfuson
J-V
JV
El Ouennass
M
M
Fagot
T
T
Forel
A
A
Branquet
D
D
Foissaud
V
V
Samson
T
T
de Revel
T
T
Nedellec
G
G
D000328:Adult; D019046:Bone Marrow Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D005334:Fever; D019788:Fluorodeoxyglucose F18; D006304:Health Status; D006689:Hodgkin Disease / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D008297:Male; D010198:Pancytopenia / Q000209:etiology; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18