title: A review of the lipid-related effects of fluvastatin.
abstract: BACKGROUND
  Statin therapy has been shown to significantly decrease vascular events and overall mortality in primary and secondary prevention trials. This review considers the pharmacology, nonlipid-lowering effects and clinical trial evidence of fluvastatin based on a survey of PubMed entries.
  
  
  RESULTS
  Recent clinical data show that treatment with fluvastatin is associated with a variety of benefits in different high-risk populations along with a good safety profile. Fluvastatin exerts non-lipid lowering-associated pleiotropic effects in both clinical and experimental studies. Furthermore, an extended-release formulation of fluvastatin with a favourable pharmacokinetic profile is available.
  
  
  CONCLUSIONS
  Treatment with fluvastatin offers a convenient, safe and evidence-based approach to managing dyslipidaemias and preventing vascular events.
authors.affiliation: Department of Internal Medicine, Medical School, University of Ioannina, Greece.
authors.forename: Evagelos N
authors.initials: EN
authors.lastname: Liberopoulos
authors.forename: Stella S
authors.initials: SS
authors.lastname: Daskalopoulou
authors.forename: Dimitri P
authors.initials: DP
authors.lastname: Mikhailidis
authors.forename: Anthony S
authors.initials: AS
authors.lastname: Wierzbicki
authors.forename: Moses S
authors.initials: MS
authors.lastname: Elisaf
mesh_terms: D003324:Coronary Artery Disease / Q000209:etiology / Q000517:prevention & control; D005229:Fatty Acids, Monounsaturated / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D000077340:Fluvastatin; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D006937:Hypercholesterolemia / Q000150:complications / Q000188:drug therapy*; D007211:Indoles / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D008055:Lipids / Q000097:blood*; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
chemical_list: D005229:Fatty Acids, Monounsaturated; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007211:Indoles; D008055:Lipids; D000077340:Fluvastatin