Emerging topics in the regulation of leukocyte transendothelial migration.
This year marks the 50th Anniversary of the founding of the Microcirculatory Society. Since the formation of this society this field has witnessed tremendous progress in understanding the process of leukocyte recruitment during inflammation, injury, and immune reactions. This topic has been an important focus of many of the members of the Microcirculatory Society as well as our colleagues worldwide. The goal of this brief review is to bring attention to a few emerging topics in inflammation research. Here the focus is on one particular model of how one leukocyte type (PMN) can regulate the recruitment of a second different leukocyte type (T cell) and provide an outline of other aspects that bear on spatial and temporal behavior of specific leukocyte and endothelial cell adhesion molecules during leukocyte transmigration under dynamic shear flow in vitro.
Rao
Ravi M
RM
Vascular Research Division, The Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Shaw
Sunil K
SK
Kim
Michael
M
Luscinskas
F William
FW
D000818:Animals; D015815:Cell Adhesion Molecules / Q000378:metabolism / Q000502:physiology; D018925:Chemokines / Q000502:physiology; D002634:Chemotaxis, Leukocyte; D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D007962:Leukocytes / Q000502:physiology*
D015815:Cell Adhesion Molecules; D018925:Chemokines