title: Maintenance or interruption of pregnancy by human chorionic gonadotrophin in adrenalectomized albino rats.
abstract: In the present study, we investigated the efficacy of human chorionic gonadotrophin (HCG) in the maintenance of pregnancy in adrenalectomized rats. Holtzman's strain albino rats were adrenalectomized on day 8 of pregnancy and at the same time were laparotomized to observe the number of implantations. Adrenalectomy on day 8 caused abortions or fetal resorption in almost all rats. Administration of 5 or 50 IU HCG in adrenalectomized rats, from day 8 through 14 or 19, was not able to maintain gestation, resulting in fetal resorption with many placentomas and placental scars. However, a single injection of 5 IU or 1 IU HCG administered on day 8 only maintained the pregnancy to full term in adrenalectomized rats. Hence, the present experiment indicates that replacement therapy of a single dose of 5 IU or 1 IU HCG might be sufficient for maintaining pregnancy in adrenalectomized rats.
authors.affiliation: Department of Zoology, Karnatak University, Dharwad 580 003, India.
authors.forename: S A
authors.initials: SA
authors.lastname: Nevagi
authors.forename: V
authors.initials: V
authors.lastname: Vani
authors.forename: L S
authors.initials: LS
authors.lastname: Doddamani
mesh_terms: D000315:Adrenalectomy / Q000009:adverse effects*; D000818:Animals; D006063:Chorionic Gonadotropin / Q000009:adverse effects* / Q000494:pharmacology*; D005260:Female; D005327:Fetal Resorption / Q000139:chemically induced* / Q000378:metabolism; D006801:Humans; D011247:Pregnancy; D011255:Pregnancy Maintenance / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D006063:Chorionic Gonadotropin