The roles of receptor and ligand endocytosis in regulating Notch signaling.
Cell-cell signaling is a central process in the formation of multicellular organisms. Notch (N) is the receptor of a conserved signaling pathway that regulates numerous developmental decisions, and the misregulation of N has been linked to various physiological and developmental disorders. The endocytosis of N and its ligands is a key mechanism by which N-mediated cell-cell signaling is developmentally regulated. We review here the recent findings that have highlighted the importance and complexity of this regulation.
Le Borgne
Roland
R
CNRS UMR 8542, Ecole Normale Supérieure, 46, rue d'Ulm 75230 Paris cedex, France.
Bardin
Allison
A
Schweisguth
François
F
D000818:Animals; D002450:Cell Communication / Q000502:physiology*; D029721:Drosophila Proteins; D004705:Endocytosis / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D007605:Juvenile Hormones / Q000378:metabolism; D008024:Ligands; D008565:Membrane Proteins / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D011506:Proteins / Q000378:metabolism; D051880:Receptors, Notch; D015398:Signal Transduction / Q000502:physiology*; D025801:Ubiquitin / Q000378:metabolism; D051316:Wiskott-Aldrich Syndrome Protein
D029721:Drosophila Proteins; D007605:Juvenile Hormones; D008024:Ligands; D008565:Membrane Proteins; D011506:Proteins; D051880:Receptors, Notch; D025801:Ubiquitin; D051316:Wiskott-Aldrich Syndrome Protein; C060606:numb protein, Drosophila