Plasma mitochondrial coupling factor 6 in patients with acute myocardial infarction.
Previous studies have shown that mitochondrial coupling factor 6 (CF6) is an endogenous peptide that inhibits prostacyclin (PGI2) synthesis in vascular endothelial cells. In this study, we measured the plasma CF6 level of patients with acute myocardial infarction (AMI) to observe dynamic changes of CF6. All patients showed elevated plasma CF6 levels upon admission for treatment of AMI. Their CF6 levels peaked approximately 72 h after the onset of AMI and remained high for 7 days. At 7 days, their CF6 levels decreased to the level seen upon admission, but not to within a normal range. Hyperlipidemic patients had significantly greater CF6 levels at 24 h after onset of AMI than patients with a normal lipid profile. On admission, the plasma CF6 level in patients with a cardiac function of Killip class > or =II was higher than that in patients with a Killip class I cardiac function. At 3 days after the onset of AMI, the plasma CF6 levels of patients with a creatinine kinase (CK) peak value > or =1,500 units/l were significantly higher than those of patients with a CK peak value <1,500 units/l (p =0.05). At 7 days after the onset of AMI, the plasma CF6 levels of patients who received no reperfusion were significantly higher than those of patients who received a successful reperfusion. The plasma CF6 levels of AMI patients at admission, at 24 h, and at 3 days after onset of symptoms correlated positively with the cardiac function by Killip classification, respectively. At 24 h after onset of AMI, the plasma CF6 levels correlated positively with plasma total cholesterol levels and low-density lipoprotein levels. At 3 days, the plasma level of CF6 correlated positively with the plasma CK peak value and correlated negatively with left ventricular ejection fraction. These results suggest that the plasma CF6 level was elevated in patients with AMI.
Ding
Wen Hui
WH
Institute of Cardiovascular Research, Peking University First Hospital, Beijing, PR China.
Chu
Song Yun
SY
Jiang
Hong Feng
HF
Cai
Da Yong
DY
Pang
Yong Zheng
YZ
Tang
Chao Shu
CS
Qi
Yong Fen
YF
D000368:Aged; D005260:Female; D006321:Heart / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000378:metabolism*; D025261:Mitochondrial Proton-Translocating ATPases / Q000097:blood*; D009203:Myocardial Infarction / Q000097:blood* / Q000503:physiopathology; D009994:Osmolar Concentration; D010086:Oxidative Phosphorylation Coupling Factors / Q000097:blood*; D017852:Phosphotransferases (Nitrogenous Group Acceptor) / Q000097:blood; D012307:Risk Factors
D010086:Oxidative Phosphorylation Coupling Factors; D017852:Phosphotransferases (Nitrogenous Group Acceptor); C000628217:F(6) ATPase; D025261:Mitochondrial Proton-Translocating ATPases