Solvent-free synthesis of functionalized flavones under microwave irradiation.
[reaction: see text] Eco-friendly direct solvent-free synthesis of flavones is achieved by microwave irradiation of phloroglucinol and beta-ketoesters. Heating with microwaves versus under classical conditions was shown to be higher yielding, cleaner, and faster. The reaction goes through a cycloaddition of an alpha-oxo ketene intermediate followed by an uncatalyzed thermal Fries rearrangement.
Seijas
Julio A
JA
Departamento de Química Orgánica, Universidad de Santiago de Compostela, Facultad de Ciencias, Aptdo. 280, 27080-Lugo, Spain. qoseijas@lugo.usc.es
Vázquez-Tato
M Pilar
MP
Carballido-Reboredo
Raquel
R
D047309:Flavones / Q000138:chemical synthesis* / Q000737:chemistry; D008872:Microwaves; D012997:Solvents / Q000737:chemistry*
D047309:Flavones; D012997:Solvents