title: The effect of normovolemic hemodilution on c-Fos protein immunoreactivity in the postischemic rat brain cortex.
abstract: The hemodilution effect was evaluated in the parietal, temporal, and basal regions of postischemic rat brain neocortex by the immunohistochemical detection of the c-Fos protein. Rats were subjected to the four-vessel-occlusion and the hemodilution was used in one group of animals. Coronal sections of rat brains were used for immunohistochemical processing of c-Fos protein after different postischemic reperfusion intervals. The number of c-Fos positive neuronal nuclei was significantly decreased in the hemodilution group after 4 h of reperfusion in the parietal and basal neocortex compared to the reperfusion without hemodilution.
authors.affiliation: Institute of Neurobiology, Slovak Academy of Sciences, Koice, Slovak Republic. nemeth@saske.sk
authors.forename: Némethová
authors.initials: N
authors.lastname: Miroslava
authors.forename: Jozef
authors.initials: J
authors.lastname: Burda
authors.forename: Viera
authors.initials: V
authors.lastname: Danielisová
authors.forename: Jozef
authors.initials: J
authors.lastname: Marala
mesh_terms: D000818:Animals; D000906:Antibodies; D017209:Apoptosis; D015415:Biomarkers; D001810:Blood Volume; D002545:Brain Ischemia / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*; D002540:Cerebral Cortex / Q000378:metabolism* / Q000473:pathology; D006438:Hemodilution; D008297:Male; D016760:Proto-Oncogene Proteins c-fos / Q000276:immunology / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000378:metabolism / Q000473:pathology / Q000628:therapy
chemical_list: D000906:Antibodies; D015415:Biomarkers; D016760:Proto-Oncogene Proteins c-fos