Necrotizing glomerulonephritis and pulmonary hemorrhage associated with carbimazole therapy.
Methimazole, carbimazole, and propylthiouracil (PTU) are the mainstays of antithyroid drug therapy. Adverse effects of these drugs have been documented in less than 15% of patients undergoing treatment for hyperthyroidism. Common problems include fever, skin rash, urticaria, arthralgias, and arthritis. Vasculitis associated with antineutrophil anticytoplasmic antibodies (ANCA) has been reported on several occasions following treatment with PTU. However, vasculitis rarely appears to be associated with carbimazole. We report the clinical history of a woman with a necrotizing glomerulonephritis and pulmonary hemorrhage associated with carbimazole therapy.
Calañas-Continente
Alfonso
A
Department of Endocrinology and Nutrition, Reina Sofía University Hospital, Córdoba, Spain. Contentine@yahoo.es
Espinosa
Mario
M
Manzano-García
Gregorio
G
Santamaría
Rafael
R
Lopez-Rubio
Fernando
F
Aljama
Pedro
P
D013956:Antithyroid Agents / Q000009:adverse effects*; D002231:Carbimazole / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D005260:Female; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000473:pathology; D006111:Graves Disease / Q000188:drug therapy*; D006470:Hemorrhage / Q000139:chemically induced* / Q000000981:diagnostic imaging; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008171:Lung Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008875:Middle Aged; D009336:Necrosis; D013902:Radiography, Thoracic; D016896:Treatment Outcome
D013956:Antithyroid Agents; D002231:Carbimazole; D003404:Creatinine