title: Randomized clinical trial of mechanical bowel preparation versus no preparation before elective left-sided colorectal surgery.
abstract: BACKGROUND
  Mechanical bowel preparation (MBP) is performed routinely before colorectal surgery to reduce the risk of postoperative infectious complications. The aim of this randomized clinical trial was to compare the outcome of patients who underwent elective left-sided colorectal surgery with or without MBP.
  
  
  METHODS
  Patients scheduled for elective left-sided colorectal resection with primary anastomosis were randomized to preoperative MBP (3 litres of polyethylene glycol) (group 1) or surgery without MBP (group 2). Postoperative abdominal infectious complications and extra-abdominal morbidity were recorded prospectively.
  
  
  RESULTS
  One hundred and fifty-three patients were included in the study, 78 in group 1 and 75 in group 2. Demographic, clinical and treatment characteristics did not differ significantly between the two groups. The overall rate of abdominal infectious complications (anastomotic leak, intra-abdominal abscess, peritonitis and wound infection) was 22 per cent in group 1 and 8 per cent in group 2 (P = 0.028). Anastomotic leak occurred in five patients (6 per cent) in group 1 and one (1 per cent) in group 2 (P = 0.210) [corrected] Extra-abdominal morbidity rates were 24 and 11 per cent respectively (P = 0.034). Hospital stay was longer for patients who had MBP (mean(s.d.) 14.9(13.1) versus 9.9(3.8) days; P = 0.024).
  
  
  CONCLUSIONS
  Elective left-sided colorectal surgery without MBP is safe and is associated with reduced postoperative morbidity.
authors.affiliation: Clinic of Visceral and Transplantation Surgery, Department of Surgery, Geneva University Hospital, Geneva 14, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Bucher
authors.forename: P
authors.initials: P
authors.lastname: Gervaz
authors.forename: C
authors.initials: C
authors.lastname: Soravia
authors.forename: B
authors.initials: B
authors.lastname: Mermillod
authors.forename: M
authors.initials: M
authors.lastname: Erne
authors.forename: P
authors.initials: P
authors.lastname: Morel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical; D019072:Antibiotic Prophylaxis / Q000379:methods; D003108:Colonic Diseases / Q000601:surgery*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control*; D011300:Preoperative Care / Q000379:methods*; D011446:Prospective Studies; D012086:Reoperation; D013529:Surgical Wound Dehiscence / Q000209:etiology; D013530:Surgical Wound Infection / Q000209:etiology
chemical_list: D011092:Polyethylene Glycols