title: Nogo expression in muscle correlates with amyotrophic lateral sclerosis severity.
abstract: Nogo, a protein inhibiting axonal regeneration, exhibits a characteristic isoform-specific pattern of expression in skeletal muscle of transgenic mice and patients with amyotrophic lateral sclerosis. Here, the increased levels of Nogo-A or Nogo-B in muscle biopsies of 15 amyotrophic lateral sclerosis patients significantly correlated with the severity of clinical disability and with the degree of muscle fiber atrophy. Nogo-A immunoreactivity was observed selectively in atrophic slow-twitch type I fibers. These results suggest that Nogo expression in muscle is a marker of amyotrophic lateral sclerosis severity.
authors.affiliation: Laboratoire de Signalisations Moléculaires et Neurodégénérescence, Université Louis Pasteur, Strasbourg, France.
authors.forename: Natasa
authors.initials: N
authors.lastname: Jokic
authors.forename: Jose-Luis
authors.initials: JL
authors.lastname: Gonzalez de Aguilar
authors.forename: Pierre-François
authors.initials: PF
authors.lastname: Pradat
authors.forename: Luc
authors.initials: L
authors.lastname: Dupuis
authors.forename: Andoni
authors.initials: A
authors.lastname: Echaniz-Laguna
authors.forename: André
authors.initials: A
authors.lastname: Muller
authors.forename: Odile
authors.initials: O
authors.lastname: Dubourg
authors.forename: Danielle
authors.initials: D
authors.lastname: Seilhean
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Hauw
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Loeffler
authors.forename: Vincent
authors.initials: V
authors.lastname: Meininger
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism*; D015415:Biomarkers / Q000032:analysis*; D015153:Blotting, Western; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018657:Muscle Fibers, Slow-Twitch / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism*; D009185:Myelin Proteins / Q000096:biosynthesis*; D000070798:Nogo Proteins; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D009185:Myelin Proteins; D000070798:Nogo Proteins; C000603199:RTN4 protein, human; C000603201:Rtn4 protein, mouse