title: [Th1/Th2 balance in acute lymphoblastic leukemia in children].
abstract: Analysis of T lymphocytes cytokine profiles allows to differ subpopulations: Th1, Th2, Th3, Tr1. Aim of the study was to assess Th1/Th2 balance in acute lymphoblastic leukemia in children at diagnosis and during/after remission induction, especially during infections. Percentages of lymphocytes T producing IFN-gamma and IL-4 were assessed by flow cytometry. We noted the rise of lymphocytes T helper producing IFN-gamma (Th1) and percentage of lymphocytes T producing IL-4 at the beginning and during remission induction was higher than in control group. During fever/infection we observed the rise of lymphocytes Th1, and no change in Th2 percentage. Summarizing we suggest Th1/Th2 imbalance and Th2 predominance in acute lymphoblastic leukemia in children.
authors.affiliation: Klinika Onkologii Dzieciecej, Samodzielny Publiczny Dzieciecy, Szpital Kliniczny Akademii Medycznej w Białymstoku. vlodek@amb.edu.pl
authors.forename: Włodzimierz
authors.initials: W
authors.lastname: Luczyński
authors.forename: Anna
authors.initials: A
authors.lastname: Stasiak-Barmuta
authors.forename: Maryna
authors.initials: M
authors.lastname: Krawczuk-Rybak
authors.forename: Iwona
authors.initials: I
authors.lastname: Malinowska
authors.forename: Michał
authors.initials: M
authors.lastname: Matysiak
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Mitura-Lesiuk
authors.forename: Jerzy
authors.initials: J
authors.lastname: Kowalczyk
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Jeromin
mesh_terms: D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D018655:Lymphocyte Count; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology*; D012074:Remission Induction; D018417:Th1 Cells / Q000378:metabolism*; D018418:Th2 Cells / Q000378:metabolism*
chemical_list: D015847:Interleukin-4; D007371:Interferon-gamma