title: FR207944, an antifungal antibiotic from Chaetomium sp. no. 217 I. Taxonomy, fermentation, and biological properties.
abstract: An antifungal antibiotic, FR207944, was isolated from the culture broth of a fungal strain Chaetomium sp. no. 217. FR207944 is a triterpene glucoside with antifungal activity against Aspergillus fumigatus and Candida albicans. Specifically, FR207944 exhibits in vitro and in vivo antifungal activity against A. fumigatus. The effects of FR207944 on the morphology of A. fumigatus were shown to be similar to those of FR901379, a known 1,3-beta-glucan synthase inhibitor. The MECs of FR207944 against A. fumigatus FP1305 and C. albicans FP633 in micro-broth dilution test were 0.039 and 1.6 mug/ml respectively. FR207944 showed good potency by subcutaneous injection and oral administration against A. fumigatus in a murine systemic infection model, with ED(50)s of 5.7 and 17 mg/kg respectively.
authors.affiliation: Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Tokodai, Tsukuba, Ibaraki, Japan. motoo_kobayashi@po.fujisawa.co.jp
authors.forename: Motoo
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kanasaki
authors.forename: Ikuko
authors.initials: I
authors.lastname: Sato
authors.forename: Fumie
authors.initials: F
authors.lastname: Abe
authors.forename: Kumiko
authors.initials: K
authors.lastname: Nitta
authors.forename: Masami
authors.initials: M
authors.lastname: Ezaki
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Sakamoto
authors.forename: Michizane
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Akihiko
authors.initials: A
authors.lastname: Fujie
authors.forename: Motohiro
authors.initials: M
authors.lastname: Hino
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Hori
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000145:classification / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D006027:Glycosides / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D051379:Mice; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D014315:Triterpenes / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; C503272:FR207944; D006027:Glycosides; D014315:Triterpenes