title: A retrospective review of visual outcome and complications in the treatment of retinoblastoma.
abstract: The aim of this study was to look at the visual outcome and treatment complications of children diagnosed with Retinoblastoma during the years 1985-2003 inclusive. A retrospective review of all patients records was performed. Patient characteristics, treatment methods and complications were recorded. Twenty eight children presented to Temple street Hospital between 1985-2003. Six of these infants had bilateral tumours. The mean age at presentation was 23.7 months. Sixty-nine percent presented with Leucocoria, of these 33% also had a squint. The mean duration of symptoms was only known in 58% and this figure was approximately 19.8 months. Enucleation was performed in 24 eyes of 24 patients. Three patients required adjuvant chemotherapy post enucleation. Two eyes was treated with external beam radiation and one eye with plaque radiotherapy. One eye (second eye) was treated with systemic chemotherapy and radiation. Five eyes of three patients were treated with systemic chemotherapy followed by adjuvant Argon laser, cryotherapy and diode laser to each eye.The complications of each treatment group was recorded. The visual outcome in the salvaged eyes was favourable. There were no deaths recorded. Though chemotherapy with adjuvant local treatments provide adequate treatment for early tumours, enucleation still plays a major role in the treatment of Retinoblastoma. The total eye salvage rate in this study was 29% with an enucleation rate of 90% in unilateral cases and 33% in bilateral cases. Sixty-six percent of bilateral eyes affected were salvaged. Seventy-one percent of tumours were diagnosed after a parent noticed a gross abnormality of the eye. This highlights the possible need for screening for retinoblastoma in the infant population.
authors.affiliation: Children's University Hospital Temple Street, Dublin, Ireland. maeveodoherty@eircom.net
authors.forename: M
authors.initials: M
authors.lastname: O'Doherty
authors.forename: B
authors.initials: B
authors.lastname: Lanigan
authors.forename: F
authors.initials: F
authors.lastname: Breathnach
authors.forename: A
authors.initials: A
authors.lastname: O'Meara
authors.forename: B
authors.initials: B
authors.lastname: Gallie
authors.forename: H
authors.initials: H
authors.lastname: Chan
authors.forename: M
authors.initials: M
authors.lastname: O'Keefe
mesh_terms: D017024:Chemotherapy, Adjuvant; D002675:Child, Preschool; D015353:Eye Enucleation; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D019572:Retinal Neoplasms / Q000175:diagnosis / Q000628:therapy*; D012175:Retinoblastoma / Q000175:diagnosis / Q000628:therapy*; D012189:Retrospective Studies; D016879:Salvage Therapy; D016896:Treatment Outcome