title: Efficacy of topical metronidazole (10 percent) in the treatment of anorectal Crohn's disease.
abstract: OBJECTIVE
  The aim of this study was to investigate the efficacy of 10 percent topical metronidazole in the treatment of symptomatic anorectal Crohn's disease.
  
  
  METHODS
  Patients with symptomatic anorectal Crohn's disease were studied in a prospective, nonblinded, nonrandomized study to evaluate the efficacy of topical 10 percent metronidazole. Perianal Crohn's Disease Activity Index and each component (pain, discharge, induration, sexual dysfunction, and type of pathology) were recorded before treatment and at four weeks. Visual analog pain score (0-10) was recorded before treatment and at weekly intervals for up to four weeks.
  
  
  RESULTS
  Fourteen patients were studied prospectively for four weeks. Mean Perianal Crohn's Disease Activity Index decreased from 8.8 +/- 0.9 before treatment to 4.1 +/- 0.7 after four weeks' treatment (P < 0.0001). Visual analog pain scores decreased from 5.4 +/- 0.7 before treatment to 2.4 +/- 0.5 at one week (P < 0.001) and to 1.0 +/- 0.4 after four weeks' treatment (P < 0.0001). Of the Perianal Crohn's Disease Activity Index components, significant decreases were noted in pain and discharge (P < 0.0001) and induration (P < 0.001).
  
  
  CONCLUSIONS
  For patients with perianal Crohn's disease, topical 10 percent metronidazole decreases the Perianal Crohn's Disease Activity Index and anorectal pain.
authors.affiliation: Georgia Colon and Rectal Surgical Clinic, Atlanta, Georgia, USA.
authors.forename: Edward E
authors.initials: EE
authors.lastname: Stringer
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Nicholson
authors.forename: David
authors.initials: D
authors.lastname: Armstrong
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001004:Anus Diseases / Q000188:drug therapy; D003424:Crohn Disease / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D010147:Pain Measurement; D011446:Prospective Studies; D012002:Rectal Diseases / Q000188:drug therapy; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
chemical_list: D000890:Anti-Infective Agents; D008795:Metronidazole