title: Neuroprotective effects of prostaglandin A1 in animal models of focal ischemia.
abstract: The present study evaluated the neuroprotective potential of prostaglandin A1 (PGA1) in rodent models of focal cerebral ischemia. PGA1 33 nmol reduced infarction volume by about 43% (P < 0.05) when administered intracerebroventricularly before and after transient ischemia in mice. PGA1 16.5-66 nmol diminished infarction volume by 18% to 27% (P < 0.01) when administered immediately following permanent ischemia in rats. PGA1 treatment also significantly ameliorated motor dysfunction after brain ischemia. These results suggest that PGA1 protects neurons from ischemic injury.
authors.affiliation: Department of Pharmacology, Soochow University School of Medicine, 48 Ren Ming Road, Suzhou 215007, PR China.
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Zhang
authors.forename: Zhi Hong
authors.initials: ZH
authors.lastname: Huang
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhu
authors.forename: Zhong-Qing
authors.initials: ZQ
authors.lastname: Liang
authors.forename: Rong
authors.initials: R
authors.lastname: Han
authors.forename: Xiao-Xia
authors.initials: XX
authors.lastname: Wang
authors.forename: Thomas N
authors.initials: TN
authors.lastname: Chase
authors.forename: Zheng-Hong
authors.initials: ZH
authors.lastname: Qin
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy / Q000473:pathology*; D004195:Disease Models, Animal; D020244:Infarction, Middle Cerebral Artery / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000473:pathology; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D011454:Prostaglandins A / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D018696:Neuroprotective Agents; D011454:Prostaglandins A; C100573:prostaglandin A1