title: Risk factors for fungal infection in paediatric liver transplant recipients.
abstract: Fungal infection (FI) is a major and potentially fatal complication in liver transplantation (LT). Published experience of FI in paediatric LT is limited. We therefore reviewed case records of 79 children, aged between 0.16 and 16 yr, who underwent LT between 1997 and 1998 to document the incidence of, and identify risk factors for, FI. Sixty-eight pre-, peri- and post-LT variables were assessed in relation to FI by univariate and multivariate analyses. The major indications for LT were biliary atresia in 26 (33%) patients, fulminant hepatic failure in 16 (20%) and intrahepatic cholestasis in 11 (14%); eight patients required re-LT. Thirty-two (40.5%) children developed a FI within 1 yr of LT. The median time to FI was 42 days (range 1-342 days). Candida spp. caused 29 (90.7%) FIs; 21 (66%) of these were Candida albicans. Although FI was associated with increased mortality, most patients responded well to antifungal treatment. The variables independently associated with FI were pre-LT fungal colonization and pyrexia and, post-LT, bacterial infection, Epstein-Barr virus (EBV) infection and tacrolimus administration. Identifying risk factors for FI should contribute to the development of strategies for prophylaxis or preemptive therapy.
authors.affiliation: Health Protection Agency London, Department of Medical Microbiology, King's College Hospital, London, UK. anita.verma@kingsch.nhs.uk
authors.forename: Anita
authors.initials: A
authors.lastname: Verma
authors.forename: Jim J
authors.initials: JJ
authors.lastname: Wade
authors.forename: Paul
authors.initials: P
authors.lastname: Cheeseman
authors.forename: Beatrice
authors.initials: B
authors.lastname: Samaroo
authors.forename: Mohemmed
authors.initials: M
authors.lastname: Rela
authors.forename: Nigel D
authors.initials: ND
authors.lastname: Heaton
authors.forename: Giorgina
authors.initials: G
authors.lastname: Mieli-Vergani
authors.forename: Anil
authors.initials: A
authors.lastname: Dhawan
mesh_terms: D000293:Adolescent; D002177:Candidiasis / Q000453:epidemiology / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D008107:Liver Diseases / Q000601:surgery; D016031:Liver Transplantation / Q000009:adverse effects*; D015999:Multivariate Analysis; D009181:Mycoses / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D007166:Immunosuppressive Agents