Second-generation organocatalysts for the highly enantioselective dynamic kinetic resolution of azlactones.
Bifunctional organocatalysts of the thiourea-tert-amine type, carrying two "matched" elements of chirality, effect the alcoholytic dynamic kinetic resolution of a variety of azlactones with up to 95% ee.
Berkessel
Albrecht
A
Institut fur Organische Chemie der Universitat zu Koln, Greinstrasse 4, D-50939, Koln, Germany. berkessel@uni-koeln.de
Mukherjee
Santanu
S
Cleemann
Felix
F
Muller
Thomas N
TN
Lex
Johann
J
D002384:Catalysis; D018360:Crystallography, X-Ray; D007700:Kinetics; D007783:Lactones / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry
D007783:Lactones; D013890:Thiourea