title: Synthesis and antimycobacterial activities of glycosylated amino alcohols and amines.
abstract: Reduction of glycosyl beta-amino esters (6-14 and 25-30) with lithium aluminum hydride resulted in glycosyl amino alcohols (15-23 and 31-36) in good yields. However, reductive amination of glycosyl aldehydes (1-3) with different amines in presence of sodium borohydride resulted in good to moderate yields of glycosyl amines (37-41). All the compounds were evaluated for antitubercular activity against Mycobacterium tuberculosis H37Ra and H37Rv. Compounds 18, 21, 35 and 36 exhibited antitubercular activities with MIC ranging from 6.25 to 3.12 microg ml(-1).
authors.affiliation: Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India.
authors.forename: D
authors.initials: D
authors.lastname: Katiyar
authors.forename: V K
authors.initials: VK
authors.lastname: Tiwari
authors.forename: N
authors.initials: N
authors.lastname: Tewari
authors.forename: S S
authors.initials: SS
authors.lastname: Verma
authors.forename: S
authors.initials: S
authors.lastname: Sinha
authors.forename: A
authors.initials: A
authors.lastname: Gaikwad
authors.forename: A
authors.initials: A
authors.lastname: Srivastava
authors.forename: V
authors.initials: V
authors.lastname: Chaturvedi
authors.forename: R
authors.initials: R
authors.lastname: Srivastava
authors.forename: B S
authors.initials: BS
authors.lastname: Srivastava
authors.forename: R P
authors.initials: RP
authors.lastname: Tripathi
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000605:Amino Alcohols / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006031:Glycosylation; D015394:Molecular Structure; D009161:Mycobacterium / Q000187:drug effects* / Q000502:physiology
chemical_list: D000588:Amines; D000605:Amino Alcohols; D000900:Anti-Bacterial Agents