Patterning polymerized lipid vesicles with soft lithography.
The applications of soft lithography in patterning polymerized lipid vesicles of 1,2-bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine on glass substrates are reported. We demonstrate that the polymerized vesicles can be used as a high molecular weight ink to be transferred from a PDMS stamp onto a glass substrate to form two-dimensional stripes with a controlled separation. By combining channel flow with dewetting within microfluidic networks, we assemble the polymerized vesicle into three-dimensional stripes and one-dimension lines on glass substrates. Atomic force microscopy shows that these patterned vesicle structures are stable on glass substrates. The simple, stable, and precise immobilization of lipid vesicles on solid substrates will open up the possibility of integrating them in biosensors and microelectronic devices.
Mahajan
Nidhi
N
Advanced Materials Processing and Analysis Center, Department of Mechanical, Materials, and Aerospace Engineering, and College of Optics and Photonics, University of Central Florida, Orlando, Florida 32816, USA.
Lu
Ruibo
R
Wu
Shin-Tson
ST
Fang
Jiyu
J