title: Case-control study of familial lung cancer risks in UK women.
abstract: Family history data from a case-control study of lung cancer conducted in the United Kingdom between 1999 and 2004 were analysed to estimate familial risks of the disease. Comparison of lung cancer prevalence in first-degree relatives of 1,482 female lung cancer cases and 1,079 female controls was undertaken using logistic regression adjusting for age and tobacco exposure. Overall, lung cancer in a first-degree relative was associated with a significant increase in the risk of lung cancer [odds ratio (OR) 1.49; 95% confidence interval (CI), 1.13-1.96]. For cases with early onset of the disease (< 60 years), the OR of lung cancer was 2.02 (95% CI, 1.22-3.34). Having 2 or more affected relatives was associated with an OR of 2.68 (95% CI, 1.29-5.55), with a significant trend in risk according to the number of relatives affected (p = 0.001). An increased risk of lung cancer associated with family history of the disease was observed when analysis was restricted to lifetime nonsmokers, although this did not reach significance (OR 1.23; 95% CI, 0.65-2.31). Results confirm previous findings and support the role of a familial predisposition to lung cancer.
authors.affiliation: Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom. athenam@icr.ac.uk
authors.forename: Athena
authors.initials: A
authors.lastname: Matakidou
authors.forename: Tim
authors.initials: T
authors.lastname: Eisen
authors.forename: Helen
authors.initials: H
authors.lastname: Bridle
authors.forename: Mary
authors.initials: M
authors.lastname: O'Brien
authors.forename: Rosalind
authors.initials: R
authors.lastname: Mutch
authors.forename: Richard S
authors.initials: RS
authors.lastname: Houlston
mesh_terms: D017668:Age of Onset; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology* / Q000235:genetics*; D008297:Male; D008487:Medical History Taking; D008875:Middle Aged; D016017:Odds Ratio; D010375:Pedigree; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D006113:United Kingdom / Q000453:epidemiology