Sudden onset of Multiple nevi after administration of 6-mercaptopurine in an adult with Crohn's disease: a case report.
The correlation between combined chemotherapy, including 6-mercaptopurine, and development of excessive number of melanocytic nevi in childhood has been previously reported and studied. As of yet, no such relation has been reported in adults. We recently observed a 27-year-old female patient who developed numerous benign melanocytic nevi during a 20-month period while taking 6-mercaptopurine for Crohn's disease. The appearance of many nevi was worrisome to the patient from a cosmetic and medical perspective (given the higher risk of melanoma associated with large numbers of nevi).
Kakrida
Marilena
M
Department of Dermatology, Baylor College of Medicine, Houston, TX, USA.
Orengo
Ida
I
Markus
Ramsey
R
D000328:Adult; D003424:Crohn Disease / Q000188:drug therapy*; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015122:Mercaptopurine / Q000009:adverse effects* / Q000627:therapeutic use; D009508:Nevus, Pigmented / Q000139:chemically induced*; D012878:Skin Neoplasms / Q000139:chemically induced*
D007166:Immunosuppressive Agents; D015122:Mercaptopurine