title: Age-related effects of bromocriptine on sensory gating in rhesus monkeys.
abstract: Declines in dopamine neurotransmission are a robust characteristic of the process of normal aging. Using neuroimaging, biochemical and cognitive methods, age-related reduction of D2 receptor has been noted in a wide range of species. On the other hand, it is well known that dopamine plays a crucial role in the modulation of sensory gating. Here, we examined age-related alterations of D2 receptor in rhesus monkeys, using a sensory gating paradigm. The direct D2 receptor agonist, bromocriptine, was characterized in young adult and aged monkeys. We found bromocriptine disrupted sensory gating in young adult monkeys but not in aged ones. Our results provided new evidence that there is a functional decline of D2 receptor in aged monkeys.
authors.affiliation: Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, PR China.
authors.forename: Ning
authors.initials: N
authors.lastname: Liu
authors.forename: Shan
authors.initials: S
authors.lastname: Yu
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Zhou
authors.forename: Jingxia
authors.initials: J
authors.lastname: Cai
authors.forename: Yuanye
authors.initials: Y
authors.lastname: Ma
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D018491:Dopamine Agonists / Q000494:pharmacology*; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D008032:Limbic System / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D008253:Macaca mulatta; D009475:Neurons, Afferent / Q000187:drug effects* / Q000502:physiology*; D017448:Receptors, Dopamine D2 / Q000378:metabolism
chemical_list: D018491:Dopamine Agonists; D017448:Receptors, Dopamine D2; D001971:Bromocriptine