title: Elevation of plasma oxidized LDL in acute stroke patients is associated with ischemic lesions depicted by DWI and predictive of infarct enlargement.
abstract: Oxidized low-density lipoprotein (OxLDL) plays a major role in atherosclerosis. We undertook the present study to clarify the relationship between plasma OxLDL and the ischemic volume. We used ELISA to determine plasma OxLDL levels, and performed diffusion- and perfusion-weighted MRI (DWI, PWI) to measure the ischemic volume in 44 ischemic stroke patients. Based on the location of the ischemic lesion, they were divided into three groups: Group I (GI, n = 21) had cortical lesions, Group II (GII, n = 17) had lesions in the basal ganglia or brain stem, and Group III (GIII, n = 6) had massive lesions that involved one entire hemisphere. In GI, but not GII and GIII, plasma OxLDL was significantly higher than in 19 age-matched controls (p < 0.01) and was significantly correlated with the initial ischemic volume visualized on DWI (p = 0.01), PWI (p < 0.01), and the DWI-PWI mismatch (p < 0.05). A persistent increase in plasma OxLDL was associated with enlargement of the ischemic lesion in the early phase after the insult. These findings suggest that elevated plasma OxLDL levels are associated with moderate ischemic damage in patients with cortical lesions (GI), but not those with massive hemispheric lesions (GIII), which may be irreversible. In addition, elevated plasma OxLDL may represent a predictor of enlargement of the ischemic lesion.
authors.affiliation: Department of Neurosurgery, School of Medicine, University of Tokushima, Tokushima, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Uno
authors.forename: Masahumi
authors.initials: M
authors.lastname: Harada
authors.forename: Osamu
authors.initials: O
authors.lastname: Takimoto
authors.forename: Keiko T
authors.initials: KT
authors.lastname: Kitazato
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Suzue
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Yoneda
authors.forename: Naomi
authors.initials: N
authors.lastname: Morita
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Itabe
authors.forename: Shinji
authors.initials: S
authors.lastname: Nagahiro
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D020520:Brain Infarction / Q000097:blood / Q000145:classification / Q000209:etiology / Q000473:pathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008077:Lipoproteins, LDL / Q000097:blood*; D018810:Magnetic Resonance Angiography / Q000379:methods; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011237:Predictive Value of Tests; D012043:Regression, Psychology; D012720:Severity of Illness Index; D020521:Stroke / Q000097:blood* / Q000150:complications; D013997:Time Factors
chemical_list: D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein