[Mechanisms of discrimation of the prolatin physiologic action on the liver at the receptor level of hepatocytes and cholangiocytes].
The role ofprolactin receptor isoforms in discrimination ofprolactin effects on liver is summarized. The necessity of studying of parameters ofprolactin receptor expression in differentially isolated different types of liver cells is demonstrated. The review is illustrated by data on different regulation by sex hormones and obstructive cholestasis of expression of prolactin receptor isoforms in rat hepatocytes and epithelial cells of bile ducts. The mathematical model is introduced for estimation of intensity of prolactin-induced signal cascades on the basis of experimentally measured parameters of prolactin receptor expression. Some further steps of the investigation of prolactin effects discrimination at the level receptor unit are suggested.
Smirnova
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Bogorad
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D000818:Animals; D002779:Cholestasis / Q000378:metabolism* / Q000473:pathology; D012739:Gonadal Steroid Hormones / Q000378:metabolism / Q000494:pharmacology; D022781:Hepatocytes / Q000378:metabolism* / Q000502:physiology; D008099:Liver / Q000378:metabolism* / Q000473:pathology / Q000502:physiology; D020033:Protein Isoforms; D012333:RNA, Messenger / Q000378:metabolism; D011981:Receptors, Prolactin / Q000096:biosynthesis / Q000502:physiology*
D012739:Gonadal Steroid Hormones; D020033:Protein Isoforms; D012333:RNA, Messenger; D011981:Receptors, Prolactin