Lipoprotein composition in children and adolescents with type 1 diabetes mellitus.
Atherosclerotic cardiovascular diseases are the major causes of morbidity and mortality in patients with diabetes mellitus. Both quantitative and qualitative abnormalities of lipo-proteins are associated with the development of atherogenesis. In this study, the prevalence of dyslipidemia and the relative levels of glycosylated lipoproteins in 20 children and adolescents with type 1 diabetes mellitus were determined. Lipid profile, apolipoproteins A-I and B, Lp(a) and LpA-I in plasma were assayed. LpB and glycosylated HDL and LDL were evaluated by ELISA. Diabetic patients and controls had normal lipid profiles, but the diabetic group showed significantly higher LpA-I and lower LpA-I:A-II concentrations than controls. The diabetic group showed a significantly higher glycosylation level of HDL than controls and did not show a statistical difference for glycosylated LDL. No significant correlation between glycosylated lipoproteins, glycemia or HbA1c was found. In conclusion, these results suggest that type 1 diabetic patients develop important qualitative lipid abnormalities.
Bustos
Paulina
P
Departamento Bioquímica Clinica e Inmunologia, Facultad de Farmacia and Universidad de Concepción, Concepción, Chile. pbustos@udec.cl
Radojkovic
Claudia
C
Ulloa
Natalia
N
Muñoz
Mirna
M
Martínez
Alejandro
A
Calvo
Carlos
C
Asenjo
Sylvia
S
D000293:Adolescent; D001161:Arteriosclerosis / Q000453:epidemiology / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000503:physiopathology; D016022:Case-Control Studies; D002648:Child; D008078:Cholesterol, LDL / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005260:Female; D006031:Glycosylation; D006801:Humans; D006949:Hyperlipidemias / Q000453:epidemiology* / Q000209:etiology*; D008074:Lipoproteins / Q000097:blood* / Q000378:metabolism*; D008297:Male; D015995:Prevalence
D008078:Cholesterol, LDL; D008074:Lipoproteins