A conserved HLA B13-restricted cytotoxic T lymphocyte epitope in Nef is a dominant epitope in HLA B13-positive HIV-1-infected patients.
We report on the first HLA B13-restricted minimal cytotoxic T lymphocyte (CTL) epitope RQDILDLWI (RI9, amino acids 106-114 in HIV-1 Nef). In most patients the frequency of RI9-specific CTL exceeded the number of CTL against other epitopes, indicating that RI9 is a dominant epitope in HLA B13-positive patients. Targeting this conserved Nef epitope may be an important factor for the published association of HLA B13 with a favourable course of HIV-1 infection.
Harrer
Ellen G
EG
Department of Medicine III, University Hospital Erlangen, 91054 Erlangen, Germany.
Bergmann
Silke
S
Eismann
Kathrin
K
Rittmaier
Marion
M
Goldwich
Andreas
A
Müller
Sandra M
SM
Spriewald
Bernd M
BM
Harrer
Thomas
T
D020816:Amino Acid Motifs; D016384:Consensus Sequence; D003602:Cytotoxicity, Immunologic; D018604:Epitope Mapping; D018984:Epitopes, T-Lymphocyte; D015693:Gene Products, nef; D015658:HIV Infections / Q000276:immunology* / Q000401:mortality; D015497:HIV-1 / Q000276:immunology* / Q000302:isolation & purification; D015235:HLA-B Antigens; D059908:HLA-B13 Antigen; D006801:Humans; D016056:Immunodominant Epitopes; D015996:Survival Rate; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D054311:nef Gene Products, Human Immunodeficiency Virus
D018984:Epitopes, T-Lymphocyte; D015693:Gene Products, nef; D015235:HLA-B Antigens; D059908:HLA-B13 Antigen; D016056:Immunodominant Epitopes; D054311:nef Gene Products, Human Immunodeficiency Virus