Calcium imaging of cortical networks dynamics.
Studies relating spontaneous network activities to cognitive processes and/or brain disorders constitute a recently expanding field of investigation. They are mostly based either on cellular recordings--usually performed in pharmacologically induced oscillations in brain slices--or on multi-cellular recordings using tetrodes or multiple electrodes. However, these research strategies cannot link the electrical recordings with morphological characterization of the neurons. The progress made in imaging techniques allows for the first time to have simultaneously a dynamic and global characterization of network activity and to determine the single-cell properties of the unitary microcircuits involved in this activity.
Cossart
Rosa
R
INMED, INSERM U29, Parc Scientifique de Luminy, BP.13, 13273 Marseille, Cedex 9, France.
Ikegaya
Yuji
Y
Yuste
Rafael
R
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D002118:Calcium / Q000032:analysis* / Q000378:metabolism; D002540:Cerebral Cortex / Q000166:cytology / Q000502:physiology*; D006801:Humans; D009434:Neural Pathways / Q000502:physiology*; D012964:Sodium / Q000378:metabolism
D012964:Sodium; D002118:Calcium