Up-date on solitary plasmacytoma and its main differences with multiple myeloma.
Solitary plasmacytoma is plasma cell neoplasm. It is a localized bone disease and for this reason it is different from multiple myeloma (systemic plasma cell neoplasm). Sometimes, solitary plasmacytoma precedes a following multiple myeloma. Clinical findings of solitary plasmacytoma are related to the univocal localization on damaged bone, while laboratory findings could be similar to multiple myeloma (i.e. M component, kidney dysfunction, blood calcium alterations, increased beta-2-microglobulin). However, during a solitary plasmacytoma, laboratory findings could not be present contemporaneously such clinical complications (i.e. kidney failure, immunological disorders with a trend toward infectious disease and/or autoimmunity, neurological disorders, haematological disorders, amyloidosis, POEMS syndrome). These raise the reason because solitary plasmacytoma has better prognosis compared to multiple myeloma.
Di Micco
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Thrombosis Center, Instituto Clinico Humanitas, Milan, Italy. pdimicco@libero.it
Di Micco
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D000368:Aged; D000818:Animals; D001859:Bone Neoplasms / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D009101:Multiple Myeloma / Q000209:etiology / Q000503:physiopathology*; D010954:Plasmacytoma / Q000209:etiology / Q000503:physiopathology*