title: Clonostachysins A and B, new anti-dinoflagellate cyclic peptides from a marine-derived fungus.
abstract: The two new anti-dinoflagellates, clonostachysins A and B, were obtained from a marine sponge derived fungus Clonostachys rogersoniana strain HJK9. Their chemical structures were determined by spectroscopic studies as highly N-methylated cyclic peptides of the nine amino acids. The absolute stereochemistry was elucidated by the advanced Marfey's method. Both clonostachysins A and B exhibited a selectively inhibitory effect on a dinoflagellate Prorocentrum micans at 30 microM, but had no effect on other microalgae and bacteria even at 100 microM.
authors.affiliation: Marine Biotechnology Institute Co. Ltd., 3-75-1 Heita, Kamaishi-shi 026-0001, Japan. kyoko.adachi@mbio.jp
authors.forename: Kyoko
authors.initials: K
authors.lastname: Adachi
authors.forename: Kaneo
authors.initials: K
authors.lastname: Kanoh
authors.forename: Puntip
authors.initials: P
authors.lastname: Wisespongp
authors.forename: Miyuki
authors.initials: M
authors.lastname: Nishijima
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Shizuri
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D001681:Biological Assay; D004141:Dinoflagellida / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010456:Peptides, Cyclic / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000981:Antiprotozoal Agents; D010456:Peptides, Cyclic; C500120:clonostachysin A; C500119:clonostachysin B