title: Fibrin glue-oxidized cellulose sandwich for laparoscopic wedge resection of small renal lesions.
abstract: OBJECTIVE
  We present our experience with standard laparoscopic wedge resection of small renal tumors using a fibrin glue-oxidized cellulose sandwich for hemostasis.
  
  
  METHODS
  From May 2002 to December 2003, 15 patients underwent laparoscopic wedge resection for a total of 15 nonhilar renal masses. Renal hilar clamping was performed in 1 patient and no sutures were placed. We used ultrasonic shears and an argon beam coagulator to resect and then coagulate the tumor bed. Tisseel (Baxter Corp., Deerfield, Illinois) was applied to the resection bed, followed by a layer of oxidized, regenerated cellulose (Surgicel, Ethicon, Somerville, New Jersey) and a final layer of Tisseel.
  
  
  RESULTS
  Mean preoperative tumor size was 2.2 x 2.2 x 2.1 cm. Lesions were subdivided based on the percent of the lesion that extended beyond the renal parenchymal border on computerized tomography as exophytic-greater than 60% in 6 cases, endophytic-less than 40% in 4 and mesophytic-40% to 60% in 5. Mean operative time was 3.8 hours (range 3 to 5). Mean blood loss was 108 ml (range 20 to 300). No patient required blood transfusion. There was no significant difference in blood loss or change in creatinine among the endophytic, exophytic and mesophytic groups (150, 121 and 93 ml, and 0.03, 0.07 and 0.04 mg/dl, respectively). Margin status was negative in all cases (mean thickness 3.2 mm). Average hospital stay and time to the resumption of oral intake were 2.7 and 1.4 days, respectively.
  
  
  CONCLUSIONS
  Small exophytic or mesophytic renal lesions can be safely excised laparoscopically without vessel clamping. Excellent hemostasis was achieved in each case with the newer hemostatic agents.
authors.affiliation: Department of Urology, University of California-Irvine, Orange, California 92868, USA.
authors.forename: David S
authors.initials: DS
authors.lastname: Finley
authors.forename: David I
authors.initials: DI
authors.lastname: Lee
authors.forename: Louis
authors.initials: L
authors.lastname: Eichel
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Uribe
authors.forename: Elspeth M
authors.initials: EM
authors.lastname: McDougall
authors.forename: Ralph V
authors.initials: RV
authors.lastname: Clayman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000601:surgery*; D002483:Cellulose, Oxidized; D005260:Female; D015718:Fibrin Tissue Adhesive; D006489:Hemostatic Techniques; D006801:Humans; D007680:Kidney Neoplasms / Q000601:surgery*; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000379:methods*
chemical_list: D002483:Cellulose, Oxidized; D015718:Fibrin Tissue Adhesive; C013695:Surgicel