title: [Age changes in the numbers of stromal precursor cells in the animal bone marrow].
abstract: Age changes of stromal precursor cell (CFU-f) numbers and their cloning efficiency (CFE-f) in monolayer cultures were evaluated using the mathematical gradient decrease method in the bone marrow of mice, guinea pigs and rats. It was found that aging was accompanied by a decline of CFE-f and CFU-f numbers in all animal species studied. However, these changes were variable in different species, that could possibly be explained by species-related physiological characteristics and aging peculiarities. Since the population of bone marrow CFU-f is known to include committed osteogenic precursor cells, these findings indicate the possibility of age-related decline in the numbers of this cell type, which could be one of the reasons of osteoporosis of aging. The application of a mathematical gradient decrease method allows to predict the course of age changes and to evaluate the dynamics of CFU-f numbers and of CFE-f in association with organism aging.
authors.forename: O V
authors.initials: OV
authors.lastname: Lebedinskaia
authors.forename: Iu F
authors.initials: IuF
authors.lastname: Gorskaia
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Shuklina
authors.forename: N V
authors.initials: NV
authors.lastname: Latsinik
authors.forename: V G
authors.initials: VG
authors.lastname: Nesterenko
mesh_terms: D000367:Age Factors; D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology*; D002478:Cells, Cultured; D005260:Female; D006168:Guinea Pigs; D008297:Male; D008432:Mathematical Computing; D051379:Mice; D008808:Mice, Inbred CBA; D051381:Rats; D017208:Rats, Wistar; D012044:Regression Analysis; D013045:Species Specificity; D013234:Stem Cells / Q000166:cytology*; D017154:Stromal Cells / Q000166:cytology