title: Alpha-1-antitrypsin phenotypes and HLA-B27 typing in uveitis patients in southeast Iran.
abstract: OBJECTIVE
  Uveitis is an eye disease that affects humans worldwide. Inflammation of the uveal tract is termed uveitis. Alpha-1-antitrypsin (AAT) deficiency is one of many factors that may be involved in abnormalities such as liver and lung disease, inflammatory joint diseases, and inflammatory eye diseases. In this study, the role of AAT in uveitis is analyzed.
  
  
  METHODS
  AAT phenotyping and serum-trypsin inhibitory capacity (S-TIC) experiments were performed on 103 patients who were referred to the ALZAHRA eye center in Zahedan (southeast of Iran). The same experiments were performed on 167 people who did not suffer from any eye or systemic diseases and served as a control group.
  
  
  RESULTS
  The results revealed that the frequency of M1S, M2S, M1Z, and MV phenotypes were significantly higher in uveitis patients (P < 0.001). There was no difference in AAT phenotype frequencies between various types of uveitis (P = 0.1).
  
  
  CONCLUSIONS
  AAT deficiency appears to be a risk factor for uveitis in southeast Iran. More investigation is needed to establish potential benefits of AAT phenotyping tests and AAT therapy in the diagnosis and treatment of uveitis cases with unclear etiology.
authors.affiliation: Department of Clinical Biochemistry, School of Medicine, Zahedan Medical University, Zahedan, Iran. ghavami@cc.unimanitoba.ca
authors.forename: Saeid
authors.initials: S
authors.lastname: Ghavami
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hashemi
authors.forename: Hossain Ali
authors.initials: HA
authors.lastname: Shahriari
authors.forename: Saeed Naghibzadeh
authors.initials: SN
authors.lastname: Bajestani
authors.forename: Frederick J
authors.initials: FJ
authors.lastname: de Serres
authors.forename: Ebrahim Miri
authors.initials: EM
authors.lastname: Moghaddam
authors.forename: Morteza
authors.initials: M
authors.lastname: Kazemi
authors.forename: Seyed Moayed
authors.initials: SM
authors.lastname: Alavian
authors.forename: Mohsen
authors.initials: M
authors.lastname: Taheri
authors.forename: Ignacio
authors.initials: I
authors.lastname: Blanco
authors.forename: Enrique
authors.initials: E
authors.lastname: Fernandez Bustillo
mesh_terms: D016022:Case-Control Studies; D005006:Ethnicity / Q000235:genetics; D015796:HLA-B27 Antigen / Q000235:genetics*; D006801:Humans; D007492:Iran; D015864:Panuveitis / Q000235:genetics; D010641:Phenotype; D014361:Trypsin Inhibitors / Q000097:blood; D014605:Uveitis / Q000235:genetics*; D014606:Uveitis, Anterior / Q000235:genetics; D015866:Uveitis, Posterior / Q000235:genetics; D000515:alpha 1-Antitrypsin / Q000235:genetics*
chemical_list: D015796:HLA-B27 Antigen; C043392:SERPINA1 protein, human; D014361:Trypsin Inhibitors; D000515:alpha 1-Antitrypsin