title: Quantitative analysis of IgE antibodies to food and inhalant allergens in 4-year-old children reflects their likelihood of allergic disease.
abstract: BACKGROUND
  It is well established that early diagnosis of allergic disease is warranted.
  
  
  METHODS
  In a prospective birth cohort study (BAMSE) 3743 children at 4 years of age were included. Children were classified as having any allergic disease, e.g. asthma, suspected allergic rhinitis (suspAR), eczema or oro-gastro-intestinal symptoms with questionnaire. Blood was obtained from 2612 of these children and analysed for IgE antibodies (ab) towards 14 common food and airborne allergens.
  
  
  RESULTS
  Positive IgE ab results were found in 38% of the children with any allergic disease, whereas such IgE ab results were found in 17% among those without any allergic disease. Furthermore, among children with any allergic disease the median summated IgE ab levels were 10.7 kU(A)/l compared with 1.5 kU(A)/l among those without such symptoms. The highest IgE ab levels were found to birch, peanut, cat and horse. When the sum of the IgE-ab levels towards the selected allergens was at least 34 kU(A)/l, or, alternatively, more than four allergen tests were positive, there was a 75% likelihood of identifying the individual with any allergic disease. To identify those with asthma, as well as those with suspAR, a significant interaction was found for the combination of the sum of IgE-ab levels and number of allergens positive at test. For eczema only, the number of positive allergens at test was associated to the likelihood of such disease.
  
  
  CONCLUSIONS
  In children, 4 years of age, allergic disease was frequently not associated with the presence of single positive IgE antibody results, whereas increased IgE ab levels were significantly more prevalent among those with allergic disease. Thus, testing a certain profile of airborne and food allergens, and utilizing the sum of the IgE-ab levels in combination with the number of allergens positive at tests, may represent a more efficient diagnostic tool then to use just single positive IgE-ab results.
authors.affiliation: Department of Occupational and Environmental Health, Stockholm County Council, Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Wickman
authors.forename: G
authors.initials: G
authors.lastname: Lilja
authors.forename: L
authors.initials: L
authors.lastname: Söderström
authors.forename: M
authors.initials: M
authors.lastname: van Hage-Hamsten
authors.forename: M
authors.initials: M
authors.lastname: van HageHamsten
authors.forename: S
authors.initials: S
authors.lastname: Ahlstedt
mesh_terms: D000328:Adult; D000485:Allergens / Q000276:immunology*; D001249:Asthma / Q000276:immunology; D002675:Child, Preschool; D015331:Cohort Studies; D019937:Diagnostic Techniques and Procedures; D004485:Eczema / Q000276:immunology; D005260:Female; D005512:Food Hypersensitivity / Q000175:diagnosis* / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D019570:Inhalation Exposure; D016013:Likelihood Functions; D008297:Male; D011446:Prospective Studies; D012130:Respiratory Hypersensitivity / Q000175:diagnosis* / Q000276:immunology*
chemical_list: D000485:Allergens; D007073:Immunoglobulin E