title: Progression of respiratory syncytial virus infection monitored by fluorescent quantum dot probes.
abstract: We report the use of quantum dots (QDs) to identify the presence and monitor the progression of respiratory syncytial virus (RSV) infection over time by labeling the F and G proteins. In addition, co-localization of these viral proteins was shown using confocal microscopy. The implications of these results are that QDs may provide a method for early, rapid detection of viral infection and open the door for future studies of the intricate spatial features cell trafficking of viral proteins.
authors.affiliation: Department of Chemistry, Vanderbilt University, Station B 351822, Nashville, Tennessee 37235-1822, USA.
authors.forename: Elizabeth L
authors.initials: EL
authors.lastname: Bentzen
authors.forename: Frances
authors.initials: F
authors.lastname: House
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Utley
authors.forename: James E
authors.initials: JE
authors.lastname: Crowe
authors.forename: David W
authors.initials: DW
authors.lastname: Wright
mesh_terms: D002460:Cell Line; D005456:Fluorescent Dyes; D006801:Humans; D045663:Quantum Dots; D018357:Respiratory Syncytial Virus Infections / Q000175:diagnosis*; D018113:Respiratory Syncytial Virus, Human / Q000502:physiology; D014759:Viral Envelope Proteins / Q000032:analysis* / Q000737:chemistry; D014760:Viral Fusion Proteins / Q000032:analysis* / Q000737:chemistry; D014779:Virus Replication / Q000502:physiology
chemical_list: D005456:Fluorescent Dyes; D014759:Viral Envelope Proteins; D014760:Viral Fusion Proteins; C116204:attachment protein G