title: Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders.
abstract: Oxidative stress including DNA oxidation is implicated in Parkinson's disease (PD). We postulated that DNA repair enzymes such as 8-oxoguanosine DNA glycosylase (OGG1) are involved in the PD process. We performed immunohistochemical and biochemical studies on brains of patients with PD and those of patients with progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) as disease controls, and control subjects. We found higher expression levels of mitochondrial isoforms of OGG1 enzymes in the substantia nigra (SN) in cases of PD. Furthermore, Western blot analysis revealed high OGG1 levels in the SN of the patients with PD. Our results indicate the importance of oxidative stress within the susceptible lesions in the pathogenesis of PD.
authors.affiliation: Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan.
authors.forename: Jiro
authors.initials: J
authors.lastname: Fukae
authors.forename: Masashi
authors.initials: M
authors.lastname: Takanashi
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Kubo
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Nishioka
authors.forename: Yusaku
authors.initials: Y
authors.lastname: Nakabeppu
authors.forename: Hideo
authors.initials: H
authors.lastname: Mori
authors.forename: Yoshikuni
authors.initials: Y
authors.lastname: Mizuno
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hattori
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001480:Basal Ganglia Diseases / Q000201:enzymology*; D015153:Blotting, Western / Q000379:methods; D001921:Brain / Q000201:enzymology* / Q000473:pathology; D016022:Case-Control Studies; D002452:Cell Count / Q000379:methods; D045647:DNA Glycosylases / Q000378:metabolism*; D003576:Electron Transport Complex IV / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000378:metabolism; D010300:Parkinson Disease / Q000201:enzymology*; D011180:Postmortem Changes; D013347:Subcellular Fractions / Q000201:enzymology; D013494:Supranuclear Palsy, Progressive / Q000201:enzymology*; D013997:Time Factors; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D014446:Tyrosine 3-Monooxygenase; D003576:Electron Transport Complex IV; D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human