title: Candida prosthetic valve endocarditis cured by caspofungin therapy without valve replacement.
abstract: A 64-year-old woman with a mechanical mitral valve prosthesis developed late-onset Candida endocarditis. Blood cultures grew Candida glabrata and Candida krusei. Transesophageal echocardiography demonstrated vegetations on the valve. The patient was not medically fit for valve replacement, but her condition was successfully treated with 6 weeks of intravenous caspofungin therapy.
authors.affiliation: Department of Cardiology, John Radcliffe Hospital, Headington, Oxford, United Kingdom. rajkumarrajendram@doctors.org.uk
authors.forename: R
authors.initials: R
authors.lastname: Rajendram
authors.forename: N J
authors.initials: NJ
authors.lastname: Alp
authors.forename: A R
authors.initials: AR
authors.lastname: Mitchell
authors.forename: I C J W
authors.initials: IC
authors.lastname: Bowler
authors.forename: J C
authors.initials: JC
authors.lastname: Forfar
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D002177:Candidiasis / Q000188:drug therapy*; D000077336:Caspofungin; D054714:Echinocandins; D004696:Endocarditis / Q000188:drug therapy* / Q000382:microbiology*; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D055666:Lipopeptides; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; D000077336:Caspofungin