A novel formal total synthesis of cephalotaxine.
A formal total synthesis of cephalotaxine (CET), the parent structure of antileukemia Cephalotaxus alkaloids, was achieved through a novel synthesis of the pentacyclic amino enone 4 by a rapid annulation of readily available beta-(3,4-methylenedioxy)phenethylamine (2), delta-valerolactone, and bromoacetone.
Li
Wei-Dong Z
WD
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China. liwd@lzu.edu.cn
Ma
Bao-Chun
BC
D000096:Acetone / Q000031:analogs & derivatives* / Q000737:chemistry; D000470:Alkaloids / Q000138:chemical synthesis; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis*; D006248:Harringtonines / Q000138:chemical synthesis*; D000077863:Homoharringtonine; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D006248:Harringtonines; D011753:Pyrones; D000096:Acetone; C052207:delta-valerolactone; C018235:bromoacetone; D000077863:Homoharringtonine