title: Triethylborane-induced intermolecular radical addition to ketimines.
abstract: The intermolecular carbon radical addition to ketimines was investigated by using triethylborane as a radical initiator. The screening of reactive radical acceptors showed that pyruvic hydrazone 3 and isatin hydrazone 7 exhibit good reactivities toward nucleophilic alkyl radicals. The reaction of 3 and 7 proceeded effectively even under aqueous-medium reaction conditions. In the presence of BF(3).OEt(2), the radical addition to chiral ketimine 11 proceeded with good diastereoselectivities.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.
authors.forename: Hideto
authors.initials: H
authors.lastname: Miyabe
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Yamaoka
authors.forename: Yoshiji
authors.initials: Y
authors.lastname: Takemoto