Increased intratumoral expression of prostate secretory protein of 94 amino acids predicts for worse disease recurrence and progression after radical prostatectomy in patients with prostate cancer.
OBJECTIVE
To examine the impact of prostate secretory protein of 94 amino acids (PSP94) expression within the primary tumor on disease recurrence and progression using radical prostatectomy specimens from patients with adenocarcinoma of the prostate.


METHODS
PSP94 immunohistochemistry was performed on 59 radical prostatectomy specimens. The degree of PSP94 expression was reported as either present (group 1) or absent (group 2). Clinical data, including survival outcome measures, were correlated with PSP94 expression.


RESULTS
The time to disease progression for group 1 was shorter compared with that for group 2 (P = 0.042). Disease-free survival was also less in group 1 than in group 2 (P = 0.033). Multivariate analyses demonstrated that PSP94 expression was an independent prognostic factor for a shorter interval to disease progression (P = 0.046) and disease-free survival (P = 0.049).


CONCLUSIONS
PSP94 expression in radical prostatectomy tumor specimens appears to be associated with worsened survival outcomes and may provide additional prognostic information.
Girvan
Andrew R
AR
Department of Surgery, Division of Urology, Clinical Cancer Research Program, The London Regional Cancer Centre, London, Ontario, Canada.
Chang
Peter
P
van Huizen
Isaac
I
Moussa
Madeleine
M
Xuan
Jim W
JW
Stitt
Larry
L
Chin
Joseph L
JL
Yamasaki
Yasuto
Y
Izawa
Jonathan I
JI
D000230:Adenocarcinoma / Q000737:chemistry / Q000378:metabolism* / Q000601:surgery*; D000368:Aged; D018450:Disease Progression; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000737:chemistry / Q000378:metabolism*; D011237:Predictive Value of Tests; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000737:chemistry / Q000378:metabolism* / Q000601:surgery*; D029584:Prostatic Secretory Proteins / Q000032:analysis / Q000096:biosynthesis*
D029584:Prostatic Secretory Proteins; C043076:beta-microseminoprotein