Sesquiterpenes from Syneilesis palmata and their cytotoxicity against human cancer cell lines in vitro.
The chromatographic separation of the MeOH extract from the aerial parts of Syneilesis palmata led to the isolation of a new sesquiterpene glycoside 4, together with four known compounds. Their structures were characterized to be 4beta,5beta-epoxy-caryophill-8,(15)-ene (1), 3beta-hydroxy-gultin-5-ene (2), 4alpha,5beta-dihydroxy-caryophill-8,(15)-ene (3), (-)-oplopan-4-one-10-alpha-O-beta-D-glucose (4) and 3-hexenyl-1-O-beta-D-glucopyranose (5), based on spectroscopic and chemical methods. Compound 2 showed moderate cytotoxicity against five human tumor cell lines in vitro with its ED50 values ranging from 5.90 to approximately 10.83 microg/mL.
Lee
Kyu Ha
KH
Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea.
Choi
Sang Un
SU
Lee
Kang Ro
KR
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D019659:Asteraceae; D045744:Cell Line, Tumor; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007723:Korea; D010936:Plant Extracts / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D010936:Plant Extracts; D012717:Sesquiterpenes