Cytotoxic constituents of the octocoral Dendronephthya gigantea.
A known monoalkyl glycerol ether, (+/-)-1-nonadecyloxy-2,3-propanediol (1) was isolated from the ethyl acetate extract of a soft coral Dendronephthya gigantea as a weakly cytotoxic constituent against four human cancer cell lines, A549, HT-29, HT-1080, and SNU-638. In addition, a known ceramide, (2S,3R,4E,8E)-N-hexadecanoyl-2-amino-4,8-octadecadiene-1,3-diol (2), was also isolated as an inactive constituent. This is the first report on the isolation of the compounds 1 and 2 from the octocoral, Dendronephthya species.
Han
Ah-Reum
AR
College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea.
Song
Jun-Im
JI
Jang
Dae Sik
DS
Min
Hye-Young
HY
Lee
Sang Kook
SK
Seo
Eun-Kyoung
EK
D000466:Alkadienes / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002518:Ceramides / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D005995:Glyceryl Ethers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans
C502704:(2S,3R,4E,8E)-N-hexadecanoyl-2-amino-4,8-octadecadiene-1,3-diol; C502705:1-nonadecyloxy-2,3-propanediol; D000466:Alkadienes; D000970:Antineoplastic Agents; D002518:Ceramides; D005995:Glyceryl Ethers