Tuberculosis post-liver transplantation: a rare but complicated disease.
BACKGROUND
Tuberculosis is a rare but serious complication after transplantation. We report a case and discuss its presentation and management.


METHODS
A 60-year-old Indonesian male presented initially with fever, acute confusion and rapidly progressive right upper lobe pneumonia 3.5 months post-liver transplant, and was diagnosed with pulmonary tuberculosis by positive sputum smear for acid-fast bacilli and tuberculosis culture.


RESULTS
Standard anti-tuberculosis therapy was administered but was complicated by interaction with cyclosporine and drug-induced cholestasis.


CONCLUSIONS
A high level of suspicion, prompt antituberculosis treatment and close follow-up are essential in management of post-transplant tuberculosis.
Lu
W
W
Liver Transplant Programme, National University Hospital, Singapore.
Wai
C T
CT
Da Costa
M
M
Tambyah
P A
PA
Prabhakaran
K
K
Lee
K H
KH
D000904:Antibiotics, Antitubercular / Q000494:pharmacology; D016572:Cyclosporine / Q000008:administration & dosage / Q000097:blood; D004347:Drug Interactions; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000097:blood; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000494:pharmacology; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000209:etiology*
D000904:Antibiotics, Antitubercular; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D012293:Rifampin