What are the reactivities of coronary arteries harvested from the hearts exposed to cold ischemic preservation?
This study was designed to determine the effects of pretransplant ischemic hypothermic period on reactivities of major coronary arteries. Eleven pigs were used. Right, left anterior descending and circumflex coronary arteries harvested from 6 pigs following single dose of cardioplegia and cardiectomy. The same procedures were performed in 5 pigs after 6 hours static 4 degrees C hypothermic preservation of the hearts. Strips prepared from these 3 coronary arteries were placed in organ chambers and contractions with acetylcholine and histamine and KCL and dilatations with noradrenaline following submaximal contractions with acetylcholine and histamine were documented. There was no statistically significant difference between results taken from both groups. The pretransplant period (until 6 hours) does not cause important differences on the reactivities of coronary arteries.
Arslan
Caner
C
University of Istanbul, Cerrahpaşa Medical Faculty, Turkey. canerkvc@yahoo.com
Ozyazgan
Sibel
S
Beşirli
Kazim
K
Cantürk
Emir
E
Sirin
Gökçe
G
Bozkurt
Kürşat
K
Akkan
Gökhan
G
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D003080:Cold Temperature; D003331:Coronary Vessels / Q000502:physiology*; D016027:Heart Transplantation; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D009926:Organ Preservation; D011189:Potassium Chloride / Q000494:pharmacology; D013552:Swine; D014661:Vasoconstriction / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology
D014665:Vasodilator Agents; D011189:Potassium Chloride; D006632:Histamine; D000109:Acetylcholine