Real-time monitoring of a digestive tract marker to reduce adverse effects of moving organs at risk (OAR) in radiotherapy for thoracic and abdominal tumors.
OBJECTIVE
To evaluate the feasibility of real-time monitoring of a fiducial marker in/near the digestive tract and to analyze the motion of organs at risk to determine a reasonable internal margin.


METHODS
We developed two methods to insert a fiducial marker into/near the digestive tract adjacent to the target volume. One method involves an intraoperative insertion technique, and the other involves endoscopic insertion into the submucosal layer of the normal digestive tract. A fluoroscopic real-time tumor-tracking radiotherapy system was used to monitor the marker.


RESULTS
Fourteen markers (2 in the mediastinum and 12 in the abdomen) were implanted intraoperatively in 14 patients with no apparent migration. Seventeen of 20 markers (13/14 in the esophagus, 1/2 in the stomach, and 3/4 in the duodenum) in 18 patients were implanted using endoscopy without dropping. No symptomatic adverse effects related to insertion were observed. The mean/standard deviation of the range of motion of the esophagus was 3.5/1.8, 8.3/3.8, and 4.0/2.6 mm for lateral, craniocaudal and anteroposterior directions, respectively, in patients with intrafractional tumor motion less than 1.0 cm.


CONCLUSIONS
Both intraoperative and endoscopic insertions of a fiducial marker into/near the digestive tract for monitoring of organs at risk were feasible. The margin for internal motion can be individualized using this system.
Hashimoto
Takayuki
T
Department of Radiology, Hokkaido University School of Medicine, Sapporo, Japan. hashimoto@pmrc.tsukuba.ac.jp
Shirato
Hiroki
H
Kato
Mototsugu
M
Yamazaki
Koichi
K
Kurauchi
Nobuaki
N
Morikawa
Toshiaki
T
Shimizu
Shinichi
S
Ahn
Yong Chan
YC
Akine
Yasuyuki
Y
Miyasaka
Kazuo
K
D000008:Abdominal Neoplasms / Q000532:radiotherapy*; D000368:Aged; D000818:Animals; D003938:Diagnostic Techniques, Digestive System / Q000295:instrumentation; D004386:Duodenum; D004947:Esophagus; D005240:Feasibility Studies; D041981:Gastrointestinal Tract; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement; D013270:Stomach; D013552:Swine; D013899:Thoracic Neoplasms / Q000532:radiotherapy*