title: Fetal growth restriction associated with measles virus infection during pregnancy.
abstract: We report on a 28-week infant with growth restriction starting after 23 weeks' gestation because of measles virus (MV) infection of the mother. Histological findings for the placenta revealed extensive fibrin deposition and necrosis of the villi, and MV antigen was demonstrated in the syncytiotrophoblast by immunostaining. The MV-specific IgM level in the infant was negative, but that of the mother was positive. Therefore, we speculate that growth restriction is not attributed to direct infection with MV, but to placental dysfunction due to a decrease in intravillous blood flow and oxygen supply to the fetus.
authors.affiliation: Department of Obstetrics and Gynecology, Asahi General Hospital, Asahi-shi, Chiba, Japan. kosuke@hospital.asahi.chiba.jp
authors.forename: Kosuke
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Makiko
authors.initials: M
authors.lastname: Tajima
authors.forename: Satoshi
authors.initials: S
authors.lastname: Toishi
authors.forename: Ken
authors.initials: K
authors.lastname: Fujimori
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Hideo
authors.initials: H
authors.lastname: Udagawa
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D005317:Fetal Growth Retardation / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008457:Measles / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis* / Q000473:pathology; D011262:Pregnancy Trimester, Second; D016216:Ultrasonography, Prenatal