Naringenin attenuates cisplatin nephrotoxicity in rats.
The effect of naringenin (NAR), a naturally occurring citrus flavanone, on the acute nephrotoxicity produced by cisplatin (7 mg/kg, i.v.) was investigated in the rat. Oral administration of NAR (20 mg/kg/day) for 10 days, starting 5 days before cisplatin single i.v. injection, produced significant protection of renal function. NAR reduced the extent of cisplatin-induced nephrotoxicity, as evidenced by significant reduction in serum urea and creatinine concentrations, decreased polyuria, reduction in body weight loss, marked reduction in urinary fractional sodium excretion and glutathione S-transferase (GST) activity, and increased creatinine clearance. Cisplatin-induced alterations in renal cortex lipid peroxides and GST activity were markedly improved by NAR. Cisplatin-induced alterations in renal cortex antioxidant defense system were greatly prevented by NAR. In cisplatin-NAR combined treatment group, antioxidant enzymes namely superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) were significantly increased to 54.5, 30.3 and 35.6%, respectively compared to cisplatin treated group. Platinum renal content was not affected by NAR treatment. The results provide further insight into the mechanisms of cisplatin-induced nephrotoxicity and confirm the antioxidant potential of NAR.
Badary
Osama A
OA
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Helwan University, Ain Helwan, PO BOX 11795, Cairo, Egypt. obadary@yahoo.com
Abdel-Maksoud
Sahar
S
Ahmed
Wafaa A
WA
Owieda
Gehan H
GH
D000818:Animals; D000970:Antineoplastic Agents / Q000037:antagonists & inhibitors / Q000633:toxicity*; D002945:Cisplatin / Q000037:antagonists & inhibitors / Q000633:toxicity*; D044950:Flavanones / Q000494:pharmacology*; D007668:Kidney / Q000737:chemistry / Q000201:enzymology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology; D007677:Kidney Function Tests; D008297:Male; D010984:Platinum / Q000032:analysis; D051381:Rats; D014508:Urea / Q000097:blood
D000970:Antineoplastic Agents; D044950:Flavanones; D010984:Platinum; D014508:Urea; C005273:naringenin; D002945:Cisplatin