Pathology of radiation and anthracycline cardiotoxicity.
Radiation-induced heart disease (RIHD) and anthracycline cardiotoxicity are two patterns of cardiac dysfunction caused by therapeutic interventions to treat malignancies. They occur in both the pediatric and adult populations and there is evidence to suggest that pediatric patients are at greater risk. This is due in part to the longer survival rates but also reflects increased susceptibility to the attendant complications caused by both therapies. Radiation can cause injury to all the components of the heart, including the vasculature, while anthracycline toxicity is generally limited to the myocardium.
Berry
Gerald J
GJ
Division of Cardiac Pathology, Department of Pathology, Stanford University Medical Center, Stanford California 94305, USA. gjberry@stanford.edu
Jorden
Michelle
M
D018943:Anthracyclines / Q000009:adverse effects; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000517:prevention & control; D003131:Combined Modality Therapy; D006321:Heart / Q000187:drug effects* / Q000528:radiation effects*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D011832:Radiation Injuries / Q000209:etiology*; D017741:Survivors
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic