Characterization of amino acids using Raman spectroscopy.
A key process in the development of new drugs is elucidation of the interaction between the drug molecule and the target protein. Such knowledge then makes it possible to make systematic structural modifications of the drug molecule to optimize the interaction. Many analytical techniques can be applied to proteins in solution such as circular dichroism, ultraviolet, and fluorescence spectroscopy but these all have limitations. In this paper, we investigate the feasibility of using relatively simple, visible light Raman spectroscopic methods to investigate amino acids and related biopolymers.
Jenkins
Amanda L
AL
Applications Division: Jasco, Inc., 8649 Commerce Dr., Easton, MD 21601, USA. Jenkins@jascoinc.com
Larsen
Richard A
RA
Williams
Timothy B
TB
D000596:Amino Acids / Q000737:chemistry*; D000818:Animals; D001704:Biopolymers / Q000737:chemistry; D002417:Cattle; D007328:Insulin / Q000737:chemistry; D010455:Peptides / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D013059:Spectrum Analysis, Raman / Q000379:methods*; D014050:Toluene / Q000737:chemistry
D000596:Amino Acids; D001704:Biopolymers; D007328:Insulin; D010455:Peptides; D011108:Polymers; D014050:Toluene