Ionic-liquid-supported peptide synthesis demonstrated by the synthesis of Leu(5)-enkephalin.
A new strategy for the synthesis of oligopeptides was developed using an ionic liquid as a soluble support. The efficiency of this ionic liquid-phase approach was demonstrated by the synthesis of a bioactive pentapeptide, Leu(5)-enkephalin, in good yield and reasonable purity. The structures and purities of the reaction intermediates in each step were verified easily by routine spectroscopic analysis, and no chromatographic procedures were needed during the synthesis.
Miao
Weishi
W
Department of Chemistry, McGill University, Montreal, Quebec, Canada H3A 2K6.
Chan
Tak-Hang
TH
D000595:Amino Acid Sequence; D004743:Enkephalin, Leucine / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis*
D009842:Oligopeptides; D004743:Enkephalin, Leucine