[Spectrophotometric determination of cinnarizine based on charge-transfer reaction].
The charge-transfer (CT) complex formed between cinnarizine as the donor and 7, 7, 8, 8-Tetracyanoquinodimethane (TCNQ) as the acceptor in acetone-methanol has been studied by spectrophotometric method. Beer's law is obeyed in the range of 0-18 microg x mL(-1) of cinnarizine. The apparent molar absorptivity of CT complex at 743 nm is 1.58 x 10(4) L x mol(-1) x cm(-1). The composition of CT complex is found to be 1 : 1 by Bent-French and Job's methods. The relative standard deviation is less than 3% (n = 10). The method has been applied to the determination of cinnarizine in tablets with satisfactory results.
Xu
B
B
Department of Chemistry, Peking Universtiy, 100871 Beijing.
Zhao
F
F
Tong
S
S
D002121:Calcium Channel Blockers / Q000737:chemistry*; D002936:Cinnarizine / Q000737:chemistry*; D004735:Energy Transfer; D013053:Spectrophotometry / Q000379:methods
D002121:Calcium Channel Blockers; D002936:Cinnarizine