title: Incongruent cerebral growth in sudden infant death syndrome.
abstract: Sudden infant death syndrome remains a leading cause of post-neonatal mortality in developed countries. Its etiopathogenic mechanisms are unknown. In this neuropathologic study, we noticed that the weights of the brains of infants who died from sudden infant death syndrome (n = 97) were invariably heavier in comparison with those of a group of age-matched controls (n = 23) issuing from the same local population. Brain edema was not a major element, and there were no significant microscopic or macroscopic cerebral anomalies in the brains from either of the study groups. Head circumference did not show a parallel increase in infants with sudden infant death syndrome. The excessive brain weight might reflect abnormal cerebral development and could be detrimental to vital neural control. In a previous study, we disclosed cytokine overexpression in the brains of these victims. Whether increased brain weight is linked to cytokine up-regulation remains, however, a moot case and merits further exploration.
authors.affiliation: Anatomic Pathology Service, Brugmann University Hospital, Brussels, Belgium. Hazim.kadhim@chu-brugmann.be
authors.forename: Hazim
authors.initials: H
authors.lastname: Kadhim
authors.forename: Guillaume
authors.initials: G
authors.lastname: Sébire
authors.forename: Monia
authors.initials: M
authors.lastname: Khalifa
authors.forename: Philippe
authors.initials: P
authors.lastname: Evrard
authors.forename: José
authors.initials: J
authors.lastname: Groswasser
authors.forename: Patricia
authors.initials: P
authors.lastname: Franco
authors.forename: André
authors.initials: A
authors.lastname: Kahn
mesh_terms: D001921:Brain / Q000254:growth & development* / Q000473:pathology*; D016022:Case-Control Studies; D002508:Cephalometry; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009929:Organ Size; D012307:Risk Factors; D013398:Sudden Infant Death / Q000209:etiology / Q000473:pathology*