title: Systemic AA-amyloidosis in a European wild boar (Sus scrofa) suffering from generalized tuberculosis.
abstract: Summary An adult female wild boar (Sus scrofa) was found moribund in Cabaneros National Park (central Spain). The animal had a markedly emaciated carcass, with body weight of 25.9 kg. At necropsy, most of the parenchymatous organs had widespread variably sized granulomas. Generalized tuberculosis was confirmed by PCR detection of Mycobacterium bovis in the mandibular lymph node. Large amounts of a hyaline, pale eosinophilic material were observed in liver, kidney and intestine. Congo red staining and green birefringence identified amyloid, which was further classified as AA type based on immunohistochemical results. It is speculated that the abundant serum amyloid A derivatives deposited in the tissues as AA-amyloid may be associated with the generalized tuberculosis. This is the first report of amyloidosis in the European wild boar.
authors.affiliation: Departament de Sanitat i d'Anatomia Animal, Facultat de Veterinària, Centre de Recerca en Sanitat Animal (CReSA), Universitat Autònoma de Barcelona, Spain. joaquim.segales@uab.es
authors.forename: J
authors.initials: J
authors.lastname: Segalés
authors.forename: J
authors.initials: J
authors.lastname: Vicente
authors.forename: L
authors.initials: L
authors.lastname: Luján
authors.forename: M J M
authors.initials: MJ
authors.lastname: Toussaint
authors.forename: E
authors.initials: E
authors.lastname: Gruys
authors.forename: C
authors.initials: C
authors.lastname: Gortázar
mesh_terms: D000686:Amyloidosis / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D000835:Animals, Wild; D002417:Cattle; D017809:Fatal Outcome; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D008198:Lymph Nodes / Q000382:microbiology; D009163:Mycobacterium bovis / Q000472:pathogenicity*; D000685:Serum Amyloid A Protein / Q000032:analysis* / Q000276:immunology; D013030:Spain; D034421:Sus scrofa; D013553:Swine Diseases / Q000209:etiology / Q000473:pathology*; D014376:Tuberculosis / Q000150:complications / Q000473:pathology / Q000662:veterinary*
chemical_list: D000685:Serum Amyloid A Protein