title: Radioisotope shuntograms at the Children's Hospital of Eastern Ontario.
abstract: BACKGROUND
  Nuclear medicine shuntograms using the radiotracer technetium-99m diethylenetriaminepentaacetic acid have been used for many years as an additional method to assess shunt patency and performance.
  
  
  METHODS
  The medical records of all children who had shuntograms performed at the Children's Hospital of Eastern Ontario between January 13, 2000, and January 10, 2003, were retrospectively reviewed. There was a total of 68 procedures in 56 patients with an average age of 9 years 3 months. During the same period there were 123 shunt revisions.
  
  
  RESULTS
  Forty-two shuntograms were reported as normal. Of these, ten were identified to be false negative. Two children with fractured shunts had shuntograms performed in order to assess for cerebrospinal fluid flow patency; the shuntograms were identified to be normal, confirming shunt dependence, and the shunt replaced. Twenty-six shuntograms were reported as abnormal in 24 patients; 17 went on to have surgery and the shunt malfunction was confirmed. Seven patients did not require surgery: five were declared shunt independent, two patients clinically improved after severe constipation was treated.
  
  
  CONCLUSIONS
  Approximately one fourth of all shuntograms reported as normal are not (false-negative rate=25%). Review of five other major studies between 1980 and 2003 have reported false-negative rates between 2 and 36%, which may be explained by variations in shuntogram protocols. A standardized method is proposed.
authors.affiliation: Division of Neurosurgery, Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Ontario, K1H 8L1, Canada. vassilyadi@cheo.on.ca
authors.forename: M
authors.initials: M
authors.lastname: Vassilyadi
authors.forename: Z L
authors.initials: ZL
authors.lastname: Tataryn
authors.forename: M A
authors.initials: MA
authors.lastname: Matzinger
authors.forename: V
authors.initials: V
authors.lastname: Briggs
authors.forename: E C G
authors.initials: EC
authors.lastname: Ventureyra
mesh_terms: D000293:Adolescent; D000328:Adult; D002557:Cerebrospinal Fluid Shunts / Q000009:adverse effects / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006761:Hospitals; D006801:Humans; D006849:Hydrocephalus / Q000000981:diagnostic imaging / Q000601:surgery; D008297:Male; D008499:Medical Records; D009864:Ontario; D011868:Radioisotopes / Q000009:adverse effects; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D016284:Technetium Tc 99m Pentetate
chemical_list: D011868:Radioisotopes; D016284:Technetium Tc 99m Pentetate