[Effects of continuous veno-venous hemofiltration on the hemodynamics of sheep with endotoxic shock].
OBJECTIVE
To study the influence of continuous veno-venous hemofiltration (CVVH) on the hemodynamics and the prognosis of sheep with endotoxic shock.


METHODS
Endotoxic shock was induced by intravenous infusion of lipopolysaccharide, L-2880, to sheep, and the animals were randomly divided to control group (NHF, endotoxin only) or treatment group (HF, endotoxin+CVVH). In the latter groups a zero-balanced CVVH was instituted with an ultrafiltration rate of 40 ml x kg(-1) x h(-1) and a blood flow rate of 80 ml/min. The hemodynamic parameters were monitored.


RESULTS
After the administration of endotoxin, the mean arterial pressure (MAP) was decreased significantly, while mean pulmonary artery pressure (MPAP) and cardiac index (CI) increased significantly in both groups (P<0.05 or P<0.01). With CVVH, MAP and stroke volume (SV) were increased significantly, and were significantly higher than that of NHF group (P<0.05 or P<0.01). CI declined progressively in NHF group and significantly lower than that of HF group, in which there was no significant change(P<0.05). No significant difference in MPAP was found between two groups (P>0.05). Moreover, plasma lactate levels were lower in NHF group than in HF group (P<0.05). After 5 hours, the sheep in HF group all survived, and 2 sheep of NHF group died.


CONCLUSIONS
Intravenous infusion of endotoxin could produce endotoxic shock in sheep. CVVH was shown to have a beneficial effect on the hemodynamics, and it gave a better prognosis in endotoxic, indicating that it might be important method to treat endotoxic shock.
Hu
Zhen-jie
ZJ
ICU, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei China.
Liu
Li-xia
LX
Sun
Li-xiao
LX
Li
Yong
Y
D000818:Animals; D004195:Disease Models, Animal; D004731:Endotoxins / Q000633:toxicity; D006439:Hemodynamics; D006440:Hemofiltration / Q000379:methods*; D008297:Male; D011897:Random Allocation; D012756:Sheep; D012772:Shock, Septic / Q000503:physiopathology* / Q000628:therapy
D004731:Endotoxins