Cellular transplantation of nephrons.
Cellular transplantation of nephrons. Embryonic renal cellular primordia transplanted into animal hosts undergo nephrogenesis in situ, become vascularized by blood vessels of host origin, exhibit excretory function, and support life in otherwise anephric hosts. Renal primordia can be transplanted across isogeneic, allogeneic, and both concordant (rat to mouse) and highly disparate (pig to rodent) xenogeneic barriers. Here I review studies exploring the therapeutic potential for renal organogenesis posttransplantation of cellular kidney primordia.
Hammerman
Marc R
MR
Renal Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA. mhammerm@wustl.edu
D000818:Animals; D017690:Cell Transplantation / Q000379:methods; D006801:Humans; D007668:Kidney / Q000166:cytology / Q000196:embryology / Q000254:growth & development; D016030:Kidney Transplantation / Q000379:methods*; D051379:Mice; D009399:Nephrons / Q000166:cytology* / Q000196:embryology / Q000637:transplantation*; D051381:Rats; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous