[The role of inflammation in the pathogenesis of atherosclerosis].
Inflammation plays an important role in the initiation and progression of coronary artery disease and the precipitation of acute coronary events. However, the inflammatory triggers are still poorly understood. Histologically, unstable atherosclerotic plaque contains activated macrophages and T lymphocytes, adhesion molecules, chemokines and cytokines, matrix-degrading enzymes and prothrombotic factors. Circulating inflammatory markers such as C-reactive protein (CRP), fibrinogen, and interleukins (especially IL-6) are increased in high-risk groups of patients and predict future risk.
Banach
Maciej
M
Klinika Kardiochirurgii oraz Oddział Kliniczny Kardiologii Interwencyjnej i Kardiodiabetologii I Katedry Kardiologii i Kardiochirurgii Uniwersytetu Medycznego w Lodzi. maciej.banach@kardiolog.pl
Markuszewski
Leszek
L
Zasłonka
Janusz
J
Grzegorczyk
Janina
J
Okoński
Piotr
P
Jegier
Bogdan
B
D002097:C-Reactive Protein / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000097:blood / Q000209:etiology* / Q000378:metabolism*; D006266:Health Education; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000150:complications* / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism; D009910:Oral Hygiene; D012307:Risk Factors
D015850:Interleukin-6; D002097:C-Reactive Protein