title: Non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma.
abstract: Non-alcoholic fatty liver disease (NAFLD) is characterized by an excessive accumulation of fatty acids and triglycerides within the cytoplasm of the hepatocytes of non-alcohol users. The natural history varies according to the initial histological diagnosis. A current consideration is that cryptogenic cirrhosis may be representative of a late stage of non-alcoholic steatohepatitis (NASH), which has lost its features of necroinflammatory activity and steatosis in up to 80% of patients. Since NASH is able to progress to cirrhosis, hepatocellular carcinoma (HCC) development may be an end-stage of this disease. We report below two clinical cases of patients diagnosed with NASH who developed HCC. The relationship between NAFLD and HCC is reviewed.
authors.affiliation: Gastroenterology and Hepatology Unit, University Hospital "Marqués de Valdecilla", Santander, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Cuadrado
authors.forename: Aitor
authors.initials: A
authors.lastname: Orive
authors.forename: Covadonga
authors.initials: C
authors.lastname: García-Suárez
authors.forename: Agustín
authors.initials: A
authors.lastname: Domínguez
authors.forename: Jose Carlos
authors.initials: JC
authors.lastname: Fernández-Escalante
authors.forename: Javier
authors.initials: J
authors.lastname: Crespo
authors.forename: Fernando
authors.initials: F
authors.lastname: Pons-Romero
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000209:etiology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D018450:Disease Progression; D005234:Fatty Liver / Q000150:complications*; D005260:Female; D005500:Follow-Up Studies; D006505:Hepatitis / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology*; D008875:Middle Aged; D009765:Obesity / Q000150:complications