Hepatic failure in a child with anti-epileptic hypersensitivity syndrome.
An 11-year-old boy developed severe hypersensitivity reaction to phenobarbitone resulted in fulminant hepatic failure. During the course of illness, he developed clinical features compatible with severe acute respiratory syndrome (SARS) that may have complicated the recovery of his underlying hypersensitivity reaction, which was subsequently controlled with intravenous immune globulin and corticosteroids.
Li
Albert M
AM
Department of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong. albertmli@cuhk.edu.hk
Nelson
Edmund As
EA
Hon
Ellis K L
EK
Cheng
Frankie W T
FW
Chan
Dorothy F Y
DF
Sin
Ngai Chuen
NC
Ma
Kwok Chiu
KC
Cheung
Kam Lau
KL
Fok
Tai Fai
TF
D000927:Anticonvulsants / Q000009:adverse effects*; D002648:Child; D004342:Drug Hypersensitivity / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D017114:Liver Failure, Acute / Q000150:complications* / Q000503:physiopathology; D008297:Male; D010634:Phenobarbital / Q000009:adverse effects*; D012640:Seizures / Q000188:drug therapy; D045169:Severe Acute Respiratory Syndrome / Q000188:drug therapy* / Q000503:physiopathology
D000927:Anticonvulsants; D016756:Immunoglobulins, Intravenous; D010634:Phenobarbital