Effect of N-cadherin misexpression by the mammary epithelium in mice.
N-cadherin is not typically expressed by epithelial cells. However, it is detected in breast cancers and increases tumor cell migration and invasion in vitro. To explore its misexpression, we generated transgenic mice with N-cadherin in the mammary epithelium. Mammary glands appeared normal and no tumors arose spontaneously. To investigate N-cadherin misexpression in mammary tumors, neu was overexpressed through breeding. Tumors developed in +/neu and N-cadherin/neu mice, although few tumors in bitransgenic mice expressed N-cadherin, and they did not differ from N-cadherin-negative tumors.
Knudsen
Karen A
KA
Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA. knudsenk@mlhs.org
Sauer
Christa
C
Johnson
Keith R
KR
Wheelock
Margaret J
MJ
D017668:Age of Onset; D000818:Animals; D015820:Cadherins / Q000235:genetics* / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism* / Q000473:pathology; D015870:Gene Expression; D007150:Immunohistochemistry; D008321:Mammary Glands, Animal / Q000378:metabolism* / Q000473:pathology; D015674:Mammary Neoplasms, Animal / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic
D015820:Cadherins