Association of 14-3-3 epsilon gene haplotype with completed suicide in Japanese.
Genetic factors have been suggested to be involved in suicide. Although some genetic factors, such as serotonergic transduction, have been associated with suicide, the results are inconsistent. There is a possibility that various signaling anomalies are involved in the biological vulnerability to suicide. We carried out a genome-wide gene-expression study in the brains of suicide victims using DNA microarrays;14-3-3 epsilon, which is related to neurogenesis, was one of the genes upregulated in the brains of suicide victims in the microarray analysis. This was confirmed by Western blot analysis. To examine the possibility of the involvement of 14-3-3 epsilon in the pathogenesis of suicide, we investigated the association of the 14-3-3 epsilon gene and completed suicide. We used three high-frequency SNPs (rs1532976, rs3752826, and rs9393) and found a significant association of two alleles (rs1532976 and rs3752826) with completed suicide (p < 0.05). Moreover, the distribution of haplotype revealed a more significant difference between completed suicide and controls (p=0.0005). This finding suggests that 14-3-3 epsilon is a potential suicide susceptibility gene and implies that dysregulation of neurogenesis may be involved in suicide.
Yanagi
Masaya
M
Division of Psychiatry and Neurology, Department of Environmental Health and Safety, Faculty of Medical Sciences, Graduate School of Medicine, Kobe University, 7-5-1 Kusunoki-cho Chuo-Ku, Kobe, 650-0017, Japan.
Shirakawa
Osamu
O
Division of Psychiatry and Neurology, Department of Environmental Health and Safety, Faculty of Medical Sciences, Graduate School of Medicine, Kobe University, 7-5-1 Kusunoki-cho Chuo-Ku, Kobe, 650-0017, Japan. sirakawa@kobe-u.ac.jp.
Kitamura
Noboru
N
Department of Psychiatry and Neurology, Kobe General City Hospital, Kobe, Japan.
Okamura
Kenji
K
Division of Psychiatry and Neurology, Department of Environmental Health and Safety, Faculty of Medical Sciences, Graduate School of Medicine, Kobe University, 7-5-1 Kusunoki-cho Chuo-Ku, Kobe, 650-0017, Japan.
Sakurai
Kaoru
K
Division of Molecular Medicine & Medical Genetics, International Center for Medical Research (ICMR), Graduate School of Medicine, Kobe University, Kobe, Japan.
Nishiguchi
Naoki
N
Division of Psychiatry and Neurology, Department of Environmental Health and Safety, Faculty of Medical Sciences, Graduate School of Medicine, Kobe University, 7-5-1 Kusunoki-cho Chuo-Ku, Kobe, 650-0017, Japan.
Hashimoto
Takeshi
T
Division of Psychiatry and Neurology, Department of Environmental Health and Safety, Faculty of Medical Sciences, Graduate School of Medicine, Kobe University, 7-5-1 Kusunoki-cho Chuo-Ku, Kobe, 650-0017, Japan.
Nushida
Hideyuki
H
Division of Legal Medicine, Department of Environmental Health and Safety, Faculty of Medical Sciences, Graduate School of Medicine, Kobe University, Kobe, Japan.
Ueno
Yasuhiro
Y
Division of Legal Medicine, Department of Environmental Health and Safety, Faculty of Medical Sciences, Graduate School of Medicine, Kobe University, Kobe, Japan.
Kanbe
Daiji
D
Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan.
Kawamura
Meiko
M
Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan.
Araki
Kazuaki
K
Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan.
Nawa
Hiroyuki
H
Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan.
Maeda
Kiyoshi
K
Division of Psychiatry and Neurology, Department of Environmental Health and Safety, Faculty of Medical Sciences, Graduate School of Medicine, Kobe University, 7-5-1 Kusunoki-cho Chuo-Ku, Kobe, 650-0017, Japan.
D048948:14-3-3 Proteins / Q000235:genetics*; D000328:Adult; D000368:Aged; D005260:Female; D020869:Gene Expression Profiling; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013405:Suicide
D048948:14-3-3 Proteins