Mixed-ligand Ru(II) complexes with 2,2'-bipyridine and aryldiazo-beta-diketonato auxillary ligands: synthesis, physico-chemical study and antitumour properties.
The complexes of Ru(II)-2,2'-bipyridyl with substituted diazopentane-2,4-diones (L1H-L5H) were synthesized and characterized by elemental analyses, conductance, FAB (fast atom bombardment) mass and spectral (IR, UV/Vis (UV/visible), NMR) studies. Molecular geometry optimization of the complexes was also made. None of the complexes luminesce. However, facilitated oxidation of Ru(II) to Ru(III) was evidenced from their lower reduction potential data. The ligands and their complexes were tested for their antitumour activity against a variety of tumour cell lines. Though activity is found to vary with the type of tumour cell lines used, yet complex 5 with naphtyldiazopentane-2,4-dione as co-ligand was found to be a potential compound as it showed in general significant activity against all cell lines studied.
Mishra
Lallan
L
Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi 221005, India. lmishrabhu@yahoo.co.in
Yadaw
Ajay K
AK
Bhattacharya
Subrato
S
Dubey
Santosh K
SK
D015082:2,2'-Dipyridyl / Q000737:chemistry* / Q000378:metabolism; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001391:Azo Compounds / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D007659:Ketones / Q000737:chemistry*; D008024:Ligands; D012428:Ruthenium / Q000737:chemistry* / Q000378:metabolism
D000970:Antineoplastic Agents; D001391:Azo Compounds; D007659:Ketones; D008024:Ligands; D015082:2,2'-Dipyridyl; D012428:Ruthenium