Structural chemoproteomics and drug discovery.
Our laboratories have developed several technologies to accelerate drug discovery process on the basis of structural chemoproteomics. They include SPS technology for the efficient determination of protein structures, SCP technology for the rapid lead generation and SDF technology for the productive lead optimization. Using these technologies, we could determine many 3D structures of target proteins bound with biologically active chemicals including the structure of phosphodiesterase 5/Viagra complex and obtain highly potent compounds in animal models of obesity, diabetes, cancer and inflammation. In this paper, we will discuss concepts and applications of structural chemoproteomics for drug discovery.
Shin
Dongkyu
D
CrystalGenomics, Inc., Asian Institute for Life Sciences, 388-1 Pungnap-dong, Songpa-gu, Seoul, 138-736, Korea.
Heo
Yong-Seok
YS
Lee
Kyung Joo
KJ
Kim
Cheol Min
CM
Yoon
Jung Min
JM
Lee
Jae Il
JI
Hyun
Young-Lan
YL
Jeon
Young Ho
YH
Lee
Tae Gyu
TG
Cho
Joong Myung
JM
Ro
Seonggu
S
D000818:Animals; D001665:Binding Sites; D015195:Drug Design; D006801:Humans; D066298:In Vitro Techniques; D008958:Models, Molecular; D015394:Molecular Structure; D010726:Phosphodiesterase Inhibitors / Q000737:chemistry; D010727:Phosphoric Diester Hydrolases / Q000737:chemistry; D040901:Proteomics
D010726:Phosphodiesterase Inhibitors; D010727:Phosphoric Diester Hydrolases