Flavonoids: from cell cycle regulation to biotechnology.
Flavonoids have been proposed to play diverse roles in plant growth and development, including defense, symbiosis, pollen development and male fertility, polar auxin transport, and protection against ultraviolet radiation. Recently, a new role in cell cycle regulation has emerged. Genetic alteration of glucuronide metabolism by altered expression of a Pisum sativum UDP-glucuronosyltransferase (PsUGT1) results in an altered cell cycle in pea, alfalfa, and Arabidopsis. In alfalfa, altered expression of PsUGT1 results in accumulation of a flavonoid-like compound that suppresses growth of cultured cells. The results are consistent with the hypothesis that PsUGT1 functions by controlling cellular levels of a factor controlling cell cycle (FCC).
Woo
Ho-Hyung
HH
Department of Plant Sciences, Division of Plant Pathology and Microbiology, University of Arizona, Tucson, AZ 85721, USA. hhwoo@email.arizona.edu
Jeong
Byeong Ryong
BR
Hawes
Martha C
MC
D001709:Biotechnology / Q000379:methods* / Q000639:trends; D002453:Cell Cycle / Q000502:physiology*; D049109:Cell Proliferation; D005419:Flavonoids / Q000378:metabolism* / Q000494:pharmacology*; D007210:Indoleacetic Acids / Q000378:metabolism; D000455:Medicago sativa / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy; D010944:Plants / Q000378:metabolism*; D030821:Plants, Genetically Modified; D011058:Pollen; D013559:Symbiosis
D005419:Flavonoids; D007210:Indoleacetic Acids