[Markers of thrombophilia in patients with retinal vein thrombosis].
BACKGROUND
Thrombophilia is an alteration of hemostasis that increases the risk to venous or arterial thrombosis. This condition may be the underlying cause of retinal vein thrombosis.


OBJECTIVE
To study the presence of thrombophilia in patients with retinal vein thrombosis.


METHODS
Prospective study of 55 patients aged 22 to 86 years, with retinal vein thrombosis (central or branch). Antithrombin III, coagulant protein C, functional protein S, resistance to activated C protein, homocysteine, prothrombin G20210A gene, lupus anticoagulant and anticardiolipin antibodies were measured in all.


RESULTS
Seventeen patients had thrombophilic markers (antiphospholipid syndrome in seven, hyperhomocysteinemia in six and resistance to protein C in three). Of these 17 patients, 53% had high blood pressure, 35% an abnormal serum lipid profile and 23% a personal history of thrombosis. The thrombosis was central in 12 (ischemic in four) and of a branch in five (ischemic in two).


CONCLUSIONS
Thrombophilic markers must be assessed in patients with retinal vein thrombosis.
Traipe
Leonidas
L
Servicio de Oftalmología, Hospital Clínico de la Universidad de Chile, Chile. ltraipe@entelchile.net
Conte
Guillermo
G
Conte
Francisco J
FJ
Ibáñez
Santiago
S
Meza
Patricio
P
Rojas
Basilio
B
Cuneo
Marianela
M
Verdaguer
Juan
J
D020016:Activated Protein C Resistance / Q000150:complications; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001780:Blood Coagulation Tests; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018455:Protein S Deficiency / Q000097:blood; D012170:Retinal Vein Occlusion / Q000097:blood / Q000209:etiology*; D012307:Risk Factors; D017678:Sex Distribution; D019851:Thrombophilia / Q000097:blood / Q000150:complications*
D015415:Biomarkers