title: [Complete resection for giant thymic carcinoma after simultaneous combination chemotherapy].
abstract: A 19-year-old man visited our hospital complaining of dyspnea. Chest X-ray and computed tomography (CT) showed a huge mass in the right anterior mediastinum. We diagnosed this as invasive thymoma by microscopic examination of specimens obtained by echo-guided needle biopsy. The patient underwent 6 courses chemotherapy [1st course : carboplatin (CBDCA) + doxorubicin hydrochloride (DXR) + vincristine sulfate (VCR) + cyclophosphamide (CPA), 2nd, 3rd-6th course : cisplatin (CDDP) + ADM + VCR + CPA]. At achievement of partial response (the reduction rate of the tumor size : 91.4%), the tumor was completely resected. The pathological examination of the resected specimens yielded a diagnosis of large cell carcinoma. Preoperative chemotherapy with ADOC regimen may be effective in advanced thymic carcinoma.
authors.affiliation: Department of Surgery, Kyoto First Red Cross Hospital, Kyoto, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Ueki
authors.forename: Y
authors.initials: Y
authors.lastname: Ueshima
authors.forename: H
authors.initials: H
authors.lastname: Kurioka
authors.forename: Y
authors.initials: Y
authors.lastname: Enoki
authors.forename: Y
authors.initials: Y
authors.lastname: Hosokawa
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D018287:Carcinoma, Large Cell / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D013945:Thymoma / Q000188:drug therapy* / Q000601:surgery*; D013953:Thymus Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D016190:Carboplatin; D002945:Cisplatin