title: Respiratory morbidity in office workers in a water-damaged building.
abstract: We conducted a study on building-related respiratory disease and associated social impact in an office building with water incursions in the northeastern United States. An initial questionnaire had 67% participation (888/1,327). Compared with the U.S. adult population, prevalence ratios were 2.2-2.5 for wheezing, lifetime asthma, and current asthma, 3.3 for adult-onset asthma, and 3.4 for symptoms improving away from work (p < 0.05). Two-thirds (66/103) of the adult-onset asthma arose after occupancy, with an incidence rate of 1.9/1,000 person-years before building occupancy and 14.5/1,000 person-years after building occupancy. We conducted a second survey on 140 respiratory cases, 63 subjects with fewer symptoms, and 44 comparison subjects. Health-related quality of life decreased with increasing severity of respiratory symptoms and in those with work-related symptoms. Symptom status was not associated with job satisfaction or how often jobs required hard work. Respiratory health problems accounted for one-third of sick leave, and respiratory cases with work-related symptoms had more respiratory sick days than those without work-related symptoms (9.4 vs. 2.4 days/year; p < 0.01). Abnormal lung function and/or breathing medication use was found in 67% of respiratory cases, in 38% of participants with fewer symptoms, and in 11% of the comparison group (p < 0.01), with similar results in never-smokers. Postoccupancy-onset asthma was associated with less atopy than preoccupancy-onset asthma. Occupancy of the water-damaged building was associated with onset and exacerbation of respiratory conditions, confirmed by objective medical tests. The morbidity and lost work time burdened both employees and employers.
authors.affiliation: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. jjc8@cdc.gov
authors.forename: Jean M
authors.initials: JM
authors.lastname: Cox-Ganser
authors.forename: Sandra K
authors.initials: SK
authors.lastname: White
authors.forename: Rebecca
authors.initials: R
authors.lastname: Jones
authors.forename: Ken
authors.initials: K
authors.lastname: Hilsbos
authors.forename: Eileen
authors.initials: E
authors.lastname: Storey
authors.forename: Paul L
authors.initials: PL
authors.lastname: Enright
authors.forename: Carol Y
authors.initials: CY
authors.lastname: Rao
authors.forename: Kathleen
authors.initials: K
authors.lastname: Kreiss
mesh_terms: D000328:Adult; D000485:Allergens; D001249:Asthma / Q000175:diagnosis / Q000453:epidemiology*; D005160:Facility Design and Construction; D005260:Female; D006801:Humans; D008297:Male; D016210:Methacholine Chloride / Q000008:administration & dosage; D009017:Morbidity; D009511:New England / Q000453:epidemiology; D011788:Quality of Life; D012120:Respiration Disorders / Q000453:epidemiology*; D012882:Skin Tests; D013147:Spirometry; D011795:Surveys and Questionnaires; D017132:Workplace
chemical_list: D000485:Allergens; D016210:Methacholine Chloride