Methyl bromide intoxication causes reversible symmetric brainstem and cerebellar MRI lesions.
Methyl bromide is toxic to the central and peripheral nervous systems. A patient with occupational exposure to this agent is described. MRI showed strikingly symmetric brainstem and cerebellar lesions. The patient's clinical course and the topography and resolution of his MRI abnormalities suggest that this condition is an energy deprivation syndrome.
Geyer
Howard L
HL
Department of Neurology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA. geyer@doctor.com
Schaumburg
Herbert H
HH
Herskovitz
Steven
S
D000328:Adult; D001928:Brain Diseases, Metabolic / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D001933:Brain Stem / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D002526:Cerebellar Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D002531:Cerebellum / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology; D020234:Gait Ataxia / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D006842:Hydrocarbons, Brominated / Q000506:poisoning*; D008279:Magnetic Resonance Imaging; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D016273:Occupational Exposure / Q000009:adverse effects; D015835:Ocular Motility Disorders / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology; D010292:Paresthesia / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology; D010525:Peripheral Nerves / Q000187:drug effects / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology; D020127:Recovery of Function; D012008:Recurrence; D014717:Vertigo / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology
D006842:Hydrocarbons, Brominated; C005218:methyl bromide