title: Influence of body size and body fat distribution on risk of uterine leiomyomata in U.S. black women.
abstract: BACKGROUND
  Uterine leiomyomata are a major source of morbidity in black women. We prospectively investigated the risk of self-reported uterine leiomyomata in relation to body mass index (BMI), weight change, height, waist and hip circumferences, and waist-to-hip ratio in a large cohort of U.S black women.
  
  
  METHODS
  Data were derived from the Black Women's Health Study, a U.S. prospective cohort study of black women who complete biannual mailed health questionnaires. From 1997 through 2001, we followed 21,506 premenopausal women with intact uteri and no prior diagnosis of uterine leiomyomata. Cox regression models were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (CIs).
  
  
  RESULTS
  After 70,345 person-years of follow up, 2146 new cases of uterine leiomyomata confirmed by ultrasound (n = 1885) or hysterectomy (n = 261) were self-reported. Compared with the thinnest women (BMI <20.0 kg/m), the multivariate IRRs for women with BMIs of 20.0-22.4, 22.5-24.9, 25.0-27.4, 27.5-29.9, 30.0-32.4, and 32.5+ kg/m were 1.34 (95% CI = 1.02-1.75), 1.39 (1.07-1.81), 1.45 (1.12-1.89), 1.47 (1.11-1.93), 1.36 (1.02-1.80), and 1.21 (0.93-1.58), respectively. IRRs were larger among parous women. Weight gain since age 18 was positively associated with risk, but only among parous women. No other anthropometric measures were associated with risk.
  
  
  CONCLUSIONS
  BMI and weight gain exhibited a complex relation with risk of uterine leiomyomata in the Black Women's Health Study. The BMI association was inverse J-shaped and findings were stronger in parous women. Weight gain was positively associated with risk among parous women only.
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, 1010 Commonwealth Avenue, Boston, MA 02215, USA. lwise@slone.bu.edu
authors.forename: Lauren A
authors.initials: LA
authors.lastname: Wise
authors.forename: Julie R
authors.initials: JR
authors.lastname: Palmer
authors.forename: Donna
authors.initials: D
authors.lastname: Spiegelman
authors.forename: Bernard L
authors.initials: BL
authors.lastname: Harlow
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Stewart
authors.forename: Lucile L
authors.initials: LL
authors.lastname: Adams-Campbell
authors.forename: Lynn
authors.initials: L
authors.lastname: Rosenberg
mesh_terms: D000273:Adipose Tissue; D000328:Adult; D001741:Black or African American; D000368:Aged; D015992:Body Mass Index; D049628:Body Size; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000209:etiology*; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014481:United States / Q000453:epidemiology; D014594:Uterine Neoplasms / Q000209:etiology*; D016387:Women's Health