Tunica albuginea acellular matrix graft for treatment of Peyronie's disease--an experimental study in dogs.
OBJECTIVE
To study the value of an acellular matrix graft of the tunica albuginea for reconstruction of the penis in cases of severe Peyronie's disease.


METHODS
In nine mongrel dogs, an acellular matrix graft of the tunica albuginea was used to cover a 30 x 10 mm2 tunical defect. Equal numbers of animals were sacrificed at 1, 3 and 6 months after surgery. Before death, an erection was induced by means of papaverine injection and cavernosography was performed. After death the penis was prepared for histopathological study.


RESULTS
All animals survived the surgery and none developed haematoma, wound infections or dehiscence. All dogs developed a straight, rigid erection. Cavernosography showed patent corpora cavernosa in all animals. The papaverine injection and cavernosographic results did not change over time. Inspection of the graft site and measurement of its length and width showed healing with no contracture. Histologically, the regenerated matrix appeared thicker than the neighbouring tunica albuginea in the 1-month group; otherwise the appearance was normal. Gradual orientation of the fibrocytes, capillaries and collagen fibres was demonstrated at 1 month and was complete at 3 and 6 months. Comparison between an implanted tunica at 6 months and a control tunica from a normal dog showed no significant histological difference.


CONCLUSIONS
A homologous acellular matrix graft of the tunica albuginea may be an alternative treatment for severe cases of Peyronie's disease.
Shokeir
Ahmed A
AA
Urology & Nephrology Center, Mansoura University, Mansoura, Egypt. ahmedshokeir@hotmail.com
Osman
Yasser
Y
El-Azab
Mohamed
M
Gabr
Mahmoud
M
Dawaba
Mohamed
M
El-Baz
Mahmoud
M
D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D004547:Elastic Tissue / Q000166:cytology / Q000637:transplantation*; D005500:Follow-Up Studies; D008297:Male; D010411:Penile Induration / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D010413:Penis / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D011859:Radiography; D019651:Plastic Surgery Procedures / Q000379:methods*; D016896:Treatment Outcome; D013521:Urologic Surgical Procedures, Male / Q000379:methods*