title: [Visual assessment of functional lungs parenchyma on HRCT and (3)He-MRI in patients after single lung transplantation: comparison with quantitative volumetric results].
abstract: OBJECTIVE
  Visual assessment of the ventilation using HRCT and (3)He-MRI in patients after single lung transplantation (SLTX). Analysis of specific ventilation defects found with (3)He-MRI and morphological changes found with HRCT.
  
  
  METHODS
  We evaluated 8male patients (54 +/- 6 years) suffering from emphysema and six patients (3males and 3 females, 58 +/- 9.5 years) suffering from idiopathic pulmonary fibrosis (IPF) after SLTX. The morphological changes at HRCT were classified and localized. In (3)He-MRI (2D FLASH), 10 to 14 slices (slice thickness 10 mm, gap 5 mm) were acquired in coronal orientation to cover the whole lung. Ventilation defects were localized and characterized. The visually estimated ventilation was recorded on a 5-point scoring system. A double threshold technique was applied to volumetric quantification in (3)He-MRI to serve as internal reference.
  
  
  RESULTS
  We found no correlation between morphological changes in HRCT and ventilation defects in (3)He-MRI. The visual assessment of ventilation in (3)He-MRI was sufficient in patients with emphysema, but this was not confirmed in patients with IPF. The visual assessment in HRCT did not correlate with the volumetric evaluation in both conditions.
  
  
  CONCLUSIONS
  The various ventilation defects were not linked to specific morphological changes. For the visually assessed ventilation in patients with emphysema, (3)He-MRI is superior to HRCT.
authors.affiliation: Klinik und Poliklinik für Radiologie, Johannes Gutenberg-Universität Mainz. juliazapo@web.de
authors.forename: J
authors.initials: J
authors.lastname: Zaporozhan
authors.forename: S
authors.initials: S
authors.lastname: Ley
authors.forename: K K
authors.initials: KK
authors.lastname: Gast
authors.forename: C P
authors.initials: CP
authors.lastname: Heussel
authors.forename: A
authors.initials: A
authors.lastname: Biedermann
authors.forename: B
authors.initials: B
authors.lastname: Eberle
authors.forename: E
authors.initials: E
authors.lastname: Mayer
authors.forename: M
authors.initials: M
authors.lastname: Thelen
authors.forename: H-U
authors.initials: HU
authors.lastname: Kauczor
mesh_terms: D004646:Emphysema / Q000175:diagnosis* / Q000601:surgery*; D005260:Female; D006371:Helium; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007554:Isotopes; D016040:Lung Transplantation / Q000000981:diagnostic imaging* / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011658:Pulmonary Fibrosis / Q000175:diagnosis* / Q000601:surgery*; D011856:Radiographic Image Enhancement / Q000379:methods; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome
chemical_list: D007554:Isotopes; D019275:Radiopharmaceuticals; D006371:Helium