The effect of free and polyethylene glycol-liposome-entrapped albendazole on larval mobility and number in Toxocara canis infected mice.
As part of our exploratory drug research on the larva migrans that causes roundworm in dogs and cats, this study was carried out to clarify the effect of free and liposome-entrapped (LE) albendazole in Toxocara canis infected mice. In infected mice, evaluation of mobility and number of larva were examined in detail in the brain, skeletal muscle and liver. Larva mobility was evaluated by using the relative mobility (RM) value. Albendazole was LE as one of the drug delivery systems (DDSs). Polyethylene glycol (PEG) was added to the liposome in order to avoid evoking a response by the reticuloendothelial system (RES). By using the albendazole PEG-LE delivery system, it was possible to target the larvae in the mouse brain and liver resulting in a decrease in the number of larvae. In the skeletal muscle of the infected mice, the intraperitoneal dosages of PEG-LE albendazole did not cause a complete decrease in the number of larvae, even though free albendazole did cause the number to decrease. Therefore, it is necessary to take into consideration the migrating stage of the larvae before the initiation of any drug administration.
Horiuchi
Akiko
A
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan.
Satou
Tadaaki
T
Akao
Nobuaki
N
Koike
Kazuo
K
Fujita
Koichiro
K
Nikaido
Tamotsu
T
D015766:Albendazole / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001921:Brain / Q000469:parasitology; D004195:Disease Models, Animal; D007274:Injections, Intraperitoneal / Q000662:veterinary; D007814:Larva; D008081:Liposomes; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009068:Movement; D011092:Polyethylene Glycols; D017166:Toxocara canis / Q000187:drug effects / Q000254:growth & development*; D014120:Toxocariasis / Q000188:drug therapy*; D016896:Treatment Outcome
D000871:Anthelmintics; D008081:Liposomes; D011092:Polyethylene Glycols; D015766:Albendazole