title: [Overwhelming course of HCV disease in patients with hypogammaglobulinemia associated with cellular immunity deficiency].
abstract: Knowledge of the physiopathological basis of the fibrogenesis in the hepatopathy by hepatitis C virus (HCV) is critical. We describe the evolution of the infection by HCV after a ten-year follow-up in patients with antibody immunodeficiency (common variable immunodeficiency (n=3) (IDVC), IgG subclasses deficiency (n=2), specific deficiency of antibodies formation (n=1). The patients were treated with a prepared intravenous immunoglobulin that was associated later with an HCV hepatitis outbreak. Five of the six patients had a positive overwhelming course (CRP) for HCV and all have changes in their hepatic biochemistry during the exposure period [ Analine Aminotransferase (ALT) (from 280 to 2720 U/L) and Aspartate Aminotransferase (AST) (from 400 to 2600) U/L)]. In less than one year, two patients with IDVC developed cirrhosis and the other patient with IDVC, an active chronic hepatitis while the other patients cured the infection without the treatment. The patients with IDVC presented lower IgG levels than the patients with antibodies deficiency before the exposure (average: seric IgG = 697 mg/dl and 1480 mg/dl respectively) and had, in addition, lower T CD4+ lymphocytes [average: T CD4+ lymphocytes = 22% (413 x 106 cells/l) and 33% (869 x 106 cells/l) respectively)]. One combination of components of humoral and cellular immunodeficiency could play a role in the accelerated evolutive course of the hepatopathy by HCV in patients with IDVC.
authors.affiliation: Servicio de Inmunología, Hospital General Universitario Gregorio Marañón, Spain. carbone@teleline.es
authors.forename: Javier
authors.initials: J
authors.lastname: Carbone
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Sarmiento
authors.forename: Eduardo
authors.initials: E
authors.lastname: Fernández-Cruz
mesh_terms: D000328:Adult; D000361:Agammaglobulinemia / Q000150:complications*; D018450:Disease Progression; D005500:Follow-Up Studies; D006526:Hepatitis C / Q000209:etiology*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D008875:Middle Aged; D013997:Time Factors