Selective and unusual fluoride ion complexation by a steroidal receptor using OH...F- and CH...F- interactions: a new motif for anion coordination?
[structure: see text] A novel cholaphane has been synthesized from a naturally occurring bile acid in just two steps. It has an ability to bind two fluoride ions selectively utilizing the glycolate motif in chloroform. This "inside-out" cyclodextrin analogue encapsulates fluoride through O-H...F(-) and C-H...F(-) interaction.
Ghosh
Sanjib
S
Department of Organic Chemistry and Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore 560 012, India.
Choudhury
Angshuman Roy
AR
Guru Row
Tayur N
TN
Maitra
Uday
U
D000838:Anions / Q000737:chemistry; D001647:Bile Acids and Salts; D002725:Chloroform / Q000737:chemistry*; D005459:Fluorides / Q000737:chemistry*; D006016:Glycolates / Q000737:chemistry; D008962:Models, Theoretical; D008968:Molecular Conformation; D011987:Receptors, Steroid / Q000737:chemistry*
D000838:Anions; D001647:Bile Acids and Salts; D006016:Glycolates; D011987:Receptors, Steroid; D002725:Chloroform; D005459:Fluorides