title: Stepwise and dramatic enhancement of anion recognition with a triple-site receptor based on the calix[4]arene framework using two different cationic effectors.
abstract: Synthesis and binding behavior of a novel multi-responsive host 1, in which two esters, two polyether moieties, two urea sites, and two bipyridine units as ion binding sites are arranged on the calix[4]arene skeleton, is reported. 1 recognizes Na(+) and Ag(+) simultaneously and quantitatively and captures an anionic guest. The ability of 1 to recognize anions, including CF(3)SO(3)(-) and BF(4)(-), remarkably increases in a stepwise manner using Na(+) and Ag(+) as effectors. The enhancement of the K(a) eventually reaches factors of 1500 and 2000 for NO(3)(-) and CF(3)SO(3)(-), respectively, in the presence of both Na(+) and Ag(+), compared to the free 1. The regulation of binding of multiple ligands may be applicable to multistep cascade systems for the amplification of molecular events, and further studies in this field could provide insight applicable to more advanced molecular devices.
authors.affiliation: Department of Chemistry, University of Tsukuba, Tsukuba, Ibaraki 305-8571, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Nabeshima
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Saiki
authors.forename: Jun
authors.initials: J
authors.lastname: Iwabuchi
authors.forename: Shigehisa
authors.initials: S
authors.lastname: Akine