title: Immunological similarities between implantation and pre-eclampsia.
abstract: OBJECTIVE
  Cytokines are involved in implantation success and failure. We envisage that they could be similarly involved in pre-eclampsia (PE).
  
  
  METHODS
  First, we review the primipaternity and primiparity concepts and then why natural killer (NK) cells are involved in implantation. We stress that the common event in all PE is vascular remodelling.
  
  
  CONCLUSIONS
  We conclude that PE could involve cytokine and/or NK dysfunctions, and propose a working hypothesis.
authors.affiliation: U 131 IN-SERM, Equipe cytokines et relation materno foetale, Hôpital Antoine Béclère, 92141 Clamart Cedex, France. gerard_chaouat@wanadoo.fr
authors.forename: Gérard
authors.initials: G
authors.lastname: Chaouat
authors.forename: Nathalie
authors.initials: N
authors.lastname: Ledée-Bataille
authors.forename: Sylvie
authors.initials: S
authors.lastname: Dubanchet
mesh_terms: D016207:Cytokines / Q000276:immunology; D010064:Embryo Implantation / Q000276:immunology*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology*; D010920:Placenta / Q000098:blood supply / Q000276:immunology*; D011225:Pre-Eclampsia / Q000209:etiology / Q000276:immunology*; D011247:Pregnancy
chemical_list: D016207:Cytokines