title: Discovery of S-phase arresting agents derived from noscapine.
abstract: Analogues of the natural product noscapine were synthesized, and their potential as antitumor agents were examined. The discovery of a novel regio- and stereoselective O-demethylation led to the synthesis of several O-alkylated analogues that induced an unexpected S-phase arrest of mammalian cells. Compound 4a was the most potent analogue inhibiting cell proliferation at an EC(50) of 1.9 microM.
authors.affiliation: Athersys, Inc., 3201 Carnegie Avenue, Cleveland, Ohio 44115-2634, USA.
authors.forename: James T
authors.initials: JT
authors.lastname: Anderson
authors.forename: Anthony E
authors.initials: AE
authors.lastname: Ting
authors.forename: Sherry
authors.initials: S
authors.lastname: Boozer
authors.forename: Kurt R
authors.initials: KR
authors.lastname: Brunden
authors.forename: Joel
authors.initials: J
authors.lastname: Danzig
authors.forename: Tom
authors.initials: T
authors.lastname: Dent
authors.forename: John J
authors.initials: JJ
authors.lastname: Harrington
authors.forename: Steven M
authors.initials: SM
authors.lastname: Murphy
authors.forename: Rob
authors.initials: R
authors.lastname: Perry
authors.forename: Amy
authors.initials: A
authors.lastname: Raber
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Rundlett
authors.forename: Jianmin
authors.initials: J
authors.lastname: Wang
authors.forename: Nancy
authors.initials: N
authors.lastname: Wang
authors.forename: Youssef L
authors.initials: YL
authors.lastname: Bennani
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009665:Noscapine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D016196:S Phase / Q000187:drug effects*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D009665:Noscapine