title: Improved ventricular function during inhalation of PGI(2) aerosol partly relies on enhanced myocardial contractility.
abstract: Inhaled prostacyclin (PGI(2)) aerosol induces selective pulmonary vasodilation. Further, it improves right ventricular (RV) function, which may largely rely on pulmonary vasodilation, but also on enhanced myocardial contractility. We investigated the effects of the inhaled PGI(2) analogs epoprostenol (EPO) and iloprost (ILO) on RV function and myocardial contractility in 9 anesthetized pigs receiving aerosolized EPO (25 and 50 ng.kg(-1).min(-1)) and, consecutively, ILO (60 ng.kg(-1).min(-1)) for 20 min each. We measured pulmonary artery pressure (PAP), RV ejection fraction (RVEF) and RV end-diastolic-volume (RV-EDV), and left ventricular end-systolic pressure-volume-relation (end-systolic elastance, E(es)). EPO and ILO reduced PAP, increased RVEF and reduced RVEDV. E(es) was enhanced during all doses tested, which reached statistical significance during EPO(25 ng) and ILO, but not during EPO(50 ng). PGI(2) aerosol enhances myocardial contractility in healthy pigs, contributing to improve RV function.
authors.affiliation: Institute for Surgical Research, Ludwig-Maximilians-University, Munich, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Kemming
authors.forename: H
authors.initials: H
authors.lastname: Kisch-Wedel
authors.forename: M
authors.initials: M
authors.lastname: Flondor
authors.forename: C
authors.initials: C
authors.lastname: Hofstetter
authors.forename: W
authors.initials: W
authors.lastname: Kreyling
authors.forename: E
authors.initials: E
authors.lastname: Thein
authors.forename: F
authors.initials: F
authors.lastname: Meisner
authors.forename: S
authors.initials: S
authors.lastname: Bruhn
authors.forename: B
authors.initials: B
authors.lastname: Zwissler
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D011464:Epoprostenol / Q000008:administration & dosage* / Q000494:pharmacology; D016285:Iloprost / Q000008:administration & dosage* / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects*; D013318:Stroke Volume / Q000187:drug effects; D013552:Swine; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000494:pharmacology; D016278:Ventricular Function, Right / Q000187:drug effects*
chemical_list: D000336:Aerosols; D014665:Vasodilator Agents; D011464:Epoprostenol; D016285:Iloprost