title: Correlation of heart rate turbulence with sympathovagal balance in patients with acute myocardial infarction.
abstract: To examine the relationship among heart rate turbulence parameters, arterial baroreflex sensitivity, and cardiac sympathetic nerve activity, 15 patients with acute myocardial infarction, presenting with sinus rhythm and > or = 3 ventricular premature beats/24 hr were studied at least 2 weeks after acute myocardial infarction. Turbulence onset (TO) and turbulence slope (TS) were averaged from 3 respective ventricular premature beats. Early heart-to-mediastinum ratio (H/M), delayed H/M, and washout rate were calculated from iodine-123-metaiodobenzylguanidine (123I MIBG) scintigraphy. Arterial baroreflex sensitivity was calculated by phenyrephrine method. Arterial baroreflex sensitivity correlated significantly with TO (r = - 0.75, p < .01) and TS (r = 0.53, p < .05). TO had no correlations with early H/M, delayed H/M, and washout rate. There were no significant correlations between TS and early H/M. However, TS had significant correlation with delayed H/M (r = 0.74, p < .01) and washout rate (r = -0.71, p < .01). Thus, heart rate turbulence of TO and TS parameters depend on sympathovagal balance.
authors.affiliation: The Second Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Iwasaki
authors.forename: Fumio
authors.initials: F
authors.lastname: Yuasa
authors.forename: Reisuke
authors.initials: R
authors.lastname: Yuyama
authors.forename: Jun
authors.initials: J
authors.lastname: Mimura
authors.forename: Akihiro
authors.initials: A
authors.lastname: Kawamura
authors.forename: Masayuki
authors.initials: M
authors.lastname: Motohiro
authors.forename: Masue
authors.initials: M
authors.lastname: Yo
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Sugiura
authors.forename: Toshiji
authors.initials: T
authors.lastname: Iwasaka
mesh_terms: D019797:3-Iodobenzylguanidine / Q000008:administration & dosage; D001158:Arteries / Q000187:drug effects / Q000503:physiopathology; D017704:Baroreflex / Q000187:drug effects / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D015637:Gated Blood-Pool Imaging; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000503:physiopathology*; D010656:Phenylephrine / Q000008:administration & dosage; D011237:Predictive Value of Tests; D011379:Prognosis; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D014630:Vagus Nerve / Q000187:drug effects / Q000503:physiopathology*
chemical_list: D019275:Radiopharmaceuticals; D010656:Phenylephrine; D019797:3-Iodobenzylguanidine