[Hormone therapy and risk for venous thromboembolism in postmenopausal women].
Oral estrogens are associated with a two-fold to three-fold increased risk of venous thromboembolism in postmenopausal women. Absolute excess risk is low but higher than for contraceptive pills. Biological data and observational studies suggest that transdermal estrogens are associated with a lower risk for venous thromboembolism than oral estrogens but safety has yet to be proved. Whether addition of progestin plays a significant role is undetermined so far.
Lacut
Karine
K
Groupe d'étude de la thrombose de Bretagne occidentale, GETBO--EA 3878, département de médecine interne et pneumologie, hôpital de la Cavale blanche, 29609 Brest Cedex.
Oger
Emmanuel
E
D000279:Administration, Cutaneous; D000284:Administration, Oral; D000368:Aged; D015914:Estrogen Replacement Therapy / Q000009:adverse effects*; D004967:Estrogens / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause; D011372:Progestins / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D012307:Risk Factors; D020246:Venous Thrombosis / Q000209:etiology*
D004967:Estrogens; D011372:Progestins