title: 3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: synthesis and biological evaluation.
abstract: A novel series of 2,6-diamino-3-acylpyridines were designed and synthesized as cyclin-dependent kinase (CDK) inhibitors. The representative compounds 2r and 11 showed potent CDK1 and CDK2 inhibitory activities and inhibited cellular proliferation in HeLa, HCT116, and A375 tumor cells.
authors.affiliation: Johnson & Johnson Pharmaceutical Research & Development L.L.C., Drug Discovery, 1000 Route 202, Raritan, New Jersey 08869, USA. rlin@prdus.jnj.com
authors.forename: Ronghui
authors.initials: R
authors.lastname: Lin
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Lu
authors.forename: Steven K
authors.initials: SK
authors.lastname: Wetter
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Connolly
authors.forename: Ignatius J
authors.initials: IJ
authors.lastname: Turchi
authors.forename: William V
authors.initials: WV
authors.lastname: Murray
authors.forename: Stuart L
authors.initials: SL
authors.lastname: Emanuel
authors.forename: Robert H
authors.initials: RH
authors.lastname: Gruninger
authors.forename: Angel R
authors.initials: AR
authors.lastname: Fuentes-Pesquera
authors.forename: Mary
authors.initials: M
authors.lastname: Adams
authors.forename: Niranjan
authors.initials: N
authors.lastname: Pandey
authors.forename: Sandra
authors.initials: S
authors.lastname: Moreno-Mazza
authors.forename: Steven A
authors.initials: SA
authors.lastname: Middleton
authors.forename: Linda K
authors.initials: LK
authors.lastname: Jolliffe
mesh_terms: D000631:Aminopyridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects*; D045744:Cell Line, Tumor; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors*; D003959:Diamines / Q000138:chemical synthesis* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
chemical_list: D000631:Aminopyridines; D000970:Antineoplastic Agents; D003959:Diamines; D004791:Enzyme Inhibitors; D018844:Cyclin-Dependent Kinases