Cytotoxic activity of pisosterol, a triterpene isolated from Pisolithus tinctorius (Mich.: Pers.) Coker & Couch, 1928.
Pisolithus tinctorius (Basidiomycete) is an ectomicorrhizal fungus found in the roots and soil surrounding of many species of eucalyptus and pine trees. The present work verified the cytotoxic potential of pisosterol, a triterpene isolated from P. tinctorius collected in the Northeast region of Brazil, on three different animal cell models: mouse erythrocytes, sea urchin embryos and tumor cells. Pisosterol lacked activity on mouse erythrocytes as well as on the development of sea urchin eggs, but strongly inhibited the growth of all seven tumor cell lines tested, especially the leukemia and melanoma cells (IC50 of 1.55, 1.84 and 1.65 microg/ ml for CEM, HL-60 and B16, respectively). The results found for pisosterol were compared with those of doxorubicin and etoposide.
Montenegro
Raquel Carvalho
RC
Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, 60430-270 Fortaleza, Ceará, Brazil.
Jimenez
Paula C
PC
Feio Farias
Rômulo Augusto
RA
Andrade-Neto
Manoel
M
Silva Bezerra
Franciglauber
F
Moraes
Maria Elisabete A
ME
de Moraes
Manoel Odorico
MO
Pessoa
Cláudia
C
Costa-Lotufo
Letícia V
LV
D000818:Animals; D001487:Basidiomycota / Q000737:chemistry* / Q000302:isolation & purification; D002470:Cell Survival / Q000187:drug effects*; D005260:Female; D018922:HL-60 Cells; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D008297:Male; D051379:Mice; D010063:Ovum / Q000166:cytology / Q000187:drug effects; D012617:Sea Urchins; D013084:Sperm-Ovum Interactions / Q000187:drug effects; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology*
D014315:Triterpenes