Central hypothyroidism in infants who were born to mothers with thyrotoxicosis before 32 weeks' gestation: 3 cases.
We describe 3 infants who were born to mothers with Graves' disease and developed central hypothyroidism that persisted for >6 months after birth. Two were preterm infants, and the other was a term infant who was born to a euthyroid mother who had been treated with an antithyroid drug since week 31 of gestation. These cases suggest that passage of thyroid hormones can occur from a thyrotoxic mother to the fetus and that the gestational period earlier than 32 weeks may be the critical time for development of central hypothyroidism.
Higuchi
Ryuzo
R
Department of Perinatal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama City 641-0012, Japan. rhiguchi@wakayama-med.ac.jp
Miyawaki
Masakazu
M
Kumagai
Takeshi
T
Okutani
Takahiro
T
Shima
Yuko
Y
Yoshiyama
Megumi
M
Ban
Hiroshi
H
Yoshikawa
Norisige
N
D005260:Female; D006111:Graves Disease / Q000150:complications*; D006801:Humans; D007037:Hypothyroidism / Q000209:etiology*; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000209:etiology*; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications; D013971:Thyrotoxicosis / Q000150:complications*; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine / Q000097:blood
D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D013974:Thyroxine