Effect of an avocado oil-rich diet over an angiotensin II-induced blood pressure response.
We studied the effect of an avocado oil-rich diet on (1) the blood pressure response to angiotensin II (AngII) and (2) the fatty acid composition of cardiac and renal membranes on male Wistar rats. The avocado oil-rich diet induced a slightly higher AngII-induced blood pressure response in the rats as compared to the control rats. In cardiac microsomes, avocado oil induced an increase in oleic acid content (13.18+/-0.33% versus 15.46+/-0.59%), while in renal microsomes, the oil decreased alpha-linolenic acid content (0.34+/-0.02% versus 0.16+/-0.12%), but increased the arachidonic acid proportion (24.02+/-0.54% versus 26.25+/-0.54%), compared to control. In conclusion, avocado oil-rich diet modifies the fatty acid content in cardiac and renal membranes in a tissue-specific manner. The rise in renal arachidonic acid suggests that diet content can be a key factor in vascular responses.
Salazar
M J
MJ
Instituto Nacional de Cardiología Ignacio Chávez, Department of Pharmacology, Juan Badiano No. 1, Col. Sección XVI, Deleg. Tlalpan, Distrito Federal, C.P. 14080, México.
El Hafidi
M
M
Pastelin
G
G
Ramírez-Ortega
M C
MC
Sánchez-Mendoza
M A
MA
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004041:Dietary Fats / Q000494:pharmacology*; D008297:Male; D008861:Microsomes / Q000737:chemistry / Q000187:drug effects; D027421:Persea; D010938:Plant Oils / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D004041:Dietary Fats; D010938:Plant Oils; D014662:Vasoconstrictor Agents; D000804:Angiotensin II