title: Childhood case of progressive multifocal leukoencephalopathy with improved clinical outcome.
abstract: A 6-year-old boy who had been in remission from acute lymphoblastic leukemia for 2.5 years presented with seizures, hemiparesis, visual loss, and white- and gray-matter lesions on cranial magnetic resonance imaging. The diagnosis of progressive multifocal leukoencephalopathy was established on the detection of JC virus DNA by polymerase chain reaction in brain tissue. The patient was administered several anticonvulsants, amantadine, acyclovir, and ganciclovir. He showed partial recovery. This case illustrates the possibility of long-term survival in progressive multifocal leukoencephalopathy with normal immunologic parameters.
authors.affiliation: Department of Pediatric Neurology, Hacettepe University, Ankara, Turkey.
authors.forename: Ercan
authors.initials: E
authors.lastname: Demir
authors.forename: Uwe G
authors.initials: UG
authors.lastname: Liebert
authors.forename: Figen
authors.initials: F
authors.lastname: Söylemezoglu
authors.forename: Kalbiye
authors.initials: K
authors.lastname: Yalaz
authors.forename: Gülsen
authors.initials: G
authors.lastname: Köse
authors.forename: Banu
authors.initials: B
authors.lastname: Anlar
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D002648:Child; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D017741:Survivors
chemical_list: D000927:Anticonvulsants; D000998:Antiviral Agents