title: Dual specificity protein phosphatases: therapeutic targets for cancer and Alzheimer's disease.
abstract: The complete sequencing of the human genome is generating many novel targets for drug discovery. Understanding the pathophysiological roles of these putative targets and assessing their suitability for therapeutic intervention has become the major hurdle for drug discovery efforts. The dual-specificity phosphatases (DSPases), which dephosphorylate serine, threonine, and tyrosine residues in the same protein substrate, have important roles in multiple signaling pathways and appear to be deregulated in cancer and Alzheimer's disease. We examine the potential of DSPases as new molecular therapeutic targets for the treatment of human disease.
authors.affiliation: Department of Pharmacology, the Combinatorial Chemistry Center and the Fiske Drug Discovery Laboratory, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
authors.forename: Alexander P
authors.initials: AP
authors.lastname: Ducruet
authors.forename: Andreas
authors.initials: A
authors.lastname: Vogt
authors.forename: Peter
authors.initials: P
authors.lastname: Wipf
authors.forename: John S
authors.initials: JS
authors.lastname: Lazo
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000201:enzymology*; D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology*; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011480:Protease Inhibitors / Q000008:administration & dosage / Q000378:metabolism
chemical_list: D011480:Protease Inhibitors; D010749:Phosphoprotein Phosphatases