Sodium stibogluconate and polymorphic ventricular tachycardia.
Numerous antimicrobials including pentavalent antimonials are implicated in causing prolong QT-interval and ventricular tachycardia. Torsades de pointes is rarely documented with use of sodium stibogluconate. Here is described a 12-yr-old girl with visceral leishmaniasis, who developed syncopal attacks, prolong QT-interval, polymorphic ventricular tachycardia and torsades de pointes after completing a course of Stibogluconate (20 mg/kg/day for 30 days). Prolong lidocaine infusion and cardioversion were life saving.
Baranwal
Arun K
AK
Department of Pediatrics, B. P. Koirala Institute of Health Sciences, Dharan, India. Baranwal1970@ yahoo.com
Mandal
Ravi N
RN
Singh
Rupa
R
Singhi
Sunit C
SC
D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D000967:Antimony Sodium Gluconate / Q000009:adverse effects*; D000981:Antiprotozoal Agents / Q000009:adverse effects*; D002648:Child; D004554:Electric Countershock; D005260:Female; D006801:Humans; D007898:Leishmaniasis, Visceral / Q000188:drug therapy; D008012:Lidocaine / Q000627:therapeutic use; D017180:Tachycardia, Ventricular / Q000139:chemically induced* / Q000628:therapy
D000889:Anti-Arrhythmia Agents; D000981:Antiprotozoal Agents; D008012:Lidocaine; D000967:Antimony Sodium Gluconate