[The preparation of the polylacticacid nanoparticles of cucurbitacin and their drug loading].
This paper introduced an experimental study of the preparation of polylacticacid (PLA) nanoparticles of cucurbitacin (CuC) using a precipitation method. The residual acetone, ratio of CuC PLA precipitates, and the relationships between the ratios of two precipitates and drug incorporation rates were measured. It appeared that the nanoparticles with 60% of PLA incorporated with 5.5% of CuC were formed when acetone was injected into the aqueous phase. As the acetone gradually evaporated, drug incorporation/encapsulation continued, with most of CuC (about 70%) formed new crystalline cores and suspended in the form of microcrystals in the medium, resulting a suspension containing both nanoparticles and microcrystals. We also concluded that this system may not necessarily be suitable for all lipophilic drugs to be prepared to PLA nanoparticles with good incorporation rate. The drug incorporation depended on the interactions among drug, PLA, and organic solvents, in addition to the solubility of the drug.
Zhang
Ji-Fen
JF
West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Hou
Shi-Xiang
SX
Liu
Hui-Lian
HL
Wang
Li
L
Hu
Ping
P
Ye
Li-Min
LM
Wang
Gao-Sen
GS
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D011232:Chemical Precipitation; D019662:Cucurbitaceae / Q000737:chemistry; D054728:Cucurbitacins; D003692:Delayed-Action Preparations; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems; D019344:Lactic Acid; D008863:Microspheres; D036103:Nanotechnology; D010316:Particle Size; D010946:Plants, Medicinal / Q000737:chemistry; D011091:Polyesters; D011108:Polymers; D014315:Triterpenes / Q000008:administration & dosage* / Q000302:isolation & purification
D000972:Antineoplastic Agents, Phytogenic; D003692:Delayed-Action Preparations; D011091:Polyesters; D011108:Polymers; D014315:Triterpenes; D019344:Lactic Acid; C033616:poly(lactide); D054728:Cucurbitacins