title: Multifocal sporotrichosis with meningeal involvement in a patient with AIDS.
abstract: This report describes a 29-year-old man with AIDS and disseminated lymphocutaneous sporotrichosis diagnosis presenting a poor therapeutic adhesion to itraconazole therapy that later evolved to neurological impairment and death. Necropsy showed granulomatous reaction and yeast-like forms similar to Sporothrix schenckii in meninges, lymph nodes, marrow bone, skin, testicles, epididymides and pancreas. Meningeal sporotrichosis cases associated to AIDS are reviewed in brief.
authors.affiliation: Departamento de Clínica Médica, Disciplina de Doenças Infecciosas e Parasitárias e, Faculdade de Medicina do Triângulo Mineiro, Uberaba, Brazil. dip_fmtm@mednet.com.br
authors.forename: Mario León
authors.initials: ML
authors.lastname: Silva-Vergara
authors.forename: Frederico Ricardo Zago
authors.initials: FR
authors.lastname: Maneira
authors.forename: Renata Mônica
authors.initials: RM
authors.lastname: De Oliveira
authors.forename: Celso Tadeu Barbosa
authors.initials: CT
authors.lastname: Santos
authors.forename: Renata Margarida
authors.initials: RM
authors.lastname: Etchebehere
authors.forename: Sheila Jorge
authors.initials: SJ
authors.lastname: Adad
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D001938:Brazil; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D016921:Meningitis, Fungal / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D013175:Sporothrix / Q000187:drug effects / Q000302:isolation & purification; D013174:Sporotrichosis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole