title: Antibodies against cytokeratin 8/18 in a patient with de novo autoimmune hepatitis after living-donor liver transplantation.
abstract: Graft dysfunction mimicking autoimmune hepatitis rarely develops after liver transplantation for nonautoimmune disease. The mechanism(s) and causes of de novo autoimmune hepatitis are unknown. We examined autoantibodies serially in a patient with de novo autoimmune hepatitis and in patients without de novo autoimmune hepatitis after liver transplantation. Anticytokeratin 8/18 antibodies were detected in the first patient's sera after the onset of de novo autoimmune hepatitis, whereas other patients without de novo autoimmune hepatitis were seronegative throughout the follow-up period even with acute cellular rejection or other cause of liver dysfunction. In conclusion, the changes in cytokeratin 8/18 in hepatocytes might be one of the sources of pathogenesis of de novo autoimmune hepatitis after liver transplantation.
authors.affiliation: Department of Pediatrics, International University of Health and Welfare, Atami Hospital, Japan. inui19@iuhw.ac.jp
authors.forename: Ayano
authors.initials: A
authors.lastname: Inui
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Sogo
authors.forename: Haruki
authors.initials: H
authors.lastname: Komatsu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Miyakawa
authors.forename: Tomoo
authors.initials: T
authors.lastname: Fujisawa
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D019693:Hepatitis, Autoimmune / Q000209:etiology / Q000276:immunology*; D022781:Hepatocytes / Q000276:immunology; D006801:Humans; D007633:Keratins / Q000276:immunology*; D017093:Liver Failure / Q000601:surgery; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D011183:Postoperative Complications / Q000276:immunology
chemical_list: D001323:Autoantibodies; D007633:Keratins