[Treatment effect of percutaneous vertebroplasty combined with interventional chemotherapy on vertebral metastases].
OBJECTIVE
Vertebral metastasis is a common manifestation of patients with advanced cancer without effective treatment. This study was to explore treatment value and efficacy of percutaneous vertebroplasty (PVP) combined with interventional chemotherapy on vertebral metastases.


METHODS
Seventy-five patients with vertebral metastases (42 men, 33 women; aged 31-76 years) were divided into 2 groups: 39 were treated by PVP combined with chemotherapy (VPCC group), and 36 were treated by PVP alone (VP group). All procedures were guided by CT scan. The results and complications were evaluated by pain questionnaire and routine follow-up.


RESULTS
Response rate was significantly higher in VPCC group than in VP group (93.0% vs. 74.4%, P < 0.05); complete response rates of VPCC group and VP group were 25.6% and 10.3%. Common complication of VPCC was transient aggravation of pain.


CONCLUSIONS
PVP may release the pain, and consolidate the vertebrae of patients with vertebral metastases. Its short-term effect may be enhanced by adding drugs into bone cement.
Cai
Hong-Yi
HY
Department of Radiology, Gansu Provincial Tumor Hospital, Lanzhou, Gansu, 730050, P. R. China. honghu333@sina.com
Liu
Xiao-Dong
XD
Cao
Hui-Ping
HP
Wang
Xiao-Qi
XQ
Zhang
Zhi-Yong
ZY
Dong
Xin-Chun
XC
D000328:Adult; D000368:Aged; D001843:Bone Cements / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000473:pathology; D003131:Combined Modality Therapy; D015251:Epirubicin / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008159:Lumbar Vertebrae; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D019637:Orthopedic Procedures / Q000379:methods*; D010147:Pain Measurement; D015641:Radiography, Interventional; D013125:Spinal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary / Q000601:surgery; D013904:Thoracic Vertebrae
D001843:Bone Cements; D015251:Epirubicin; D008727:Methotrexate