title: Towards multifunctional antioxidants: synthesis, electrochemistry, in vitro and cell culture evaluation of compounds with ligand/catalytic properties.
abstract: Numerous human diseases are linked to a biochemical condition known as oxidative stress (OS). Antioxidants are therefore becoming increasingly important as potential disease prevention and therapeutic agents. Since OS is a multi-stressor event, agents combining a range of different antioxidant properties, such as redox catalysis and metal binding, might be more effective and selective than mono-functional agents. Selenium derivatives of aniline and pyridine combine redox activity with metal binding properties. These multifunctional agents have a distinct electrochemical profile, and exhibit good catalytic activity in the glutathione peroxidase mimic and metallothionein assays. They also show antioxidant activity in a skin cell model of UVA-induced stress. These compounds might therefore provide the basis for novel agents combining two or more distinct antioxidant properties.
authors.affiliation: Biocatalysis Centre, School of Biological and Chemical Science, University of Exeter, UK.
authors.forename: Catriona A
authors.initials: CA
authors.lastname: Collins
authors.forename: Fiona H
authors.initials: FH
authors.lastname: Fry
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Holme
authors.forename: Anthie
authors.initials: A
authors.lastname: Yiakouvaki
authors.forename: Abdullah
authors.initials: A
authors.lastname: Al-Qenaei
authors.forename: Charareh
authors.initials: C
authors.lastname: Pourzand
authors.forename: Claus
authors.initials: C
authors.lastname: Jacob
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D002460:Cell Line; D003300:Copper / Q000737:chemistry; D004563:Electrochemistry; D005347:Fibroblasts; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D009195:Peroxidase / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000737:chemistry
chemical_list: D000975:Antioxidants; D008024:Ligands; D017382:Reactive Oxygen Species; D003300:Copper; D009195:Peroxidase