[Usefulness of anti-citrullinated protein antibodies in the diagnosis and prognosis of rheumatoid arthritis].
Rheumatoid factors were the first biological markers used in diagnosis of rheumatoid arthritis. Their detection is rather sensitive but lack specificity. In contrast, anti-citrullinated protein antibody detection has recently been shown to have a reasonable sensitivity and a high diagnostic specificity. These autoantibodies can be present early in the disease and predict erosive arthritis. Even if an improvement of sensitivity is desirable, the anti-citrullinated protein antibody detection meets many of the requirements of a useful serological marker for rheumatoid arthritis. Its prognostic potential may provide an indication for aggressive treatment. Consequently, incorporation of anti-citrullinated protein antibody positivity as an extra criteria would improve the accuracy of the American College of Rheumatology criteria, commonly used for disease classification.
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Service de rhumatologie, Département de médecine interne, HUG - Hôpital Beau-Séjour 1211 Genève 14. Sylvette.Bas@hcuge.ch
D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000175:diagnosis* / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D006801:Humans; D010456:Peptides, Cyclic / Q000276:immunology*; D011379:Prognosis
D001323:Autoantibodies; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide