Antecedent hypertension interacts with adverse ventricular remodeling after myocardial infarction.
BACKGROUND
Ventricular remodeling is an independent predictor of left ventricular function in patients with myocardial infarction (MI). Accelerated ventricular remodeling is a probable contributor to the increased mortality observed after MI in hypertensive patients. The purpose of this study is to assess the relationship of antecedent hypertension to ventricular remodeling after MI.


METHODS
Seventy-nine patients presenting with a first acute MI (AMI) who were treated and attained Thrombolysis In Myocardial Infarction (TIMI) flow grade 3 with re-perfusion therapy within 12 hours of their symptom onset were enrolled in this study. All of them underwent left ventriculography (LVG) immediately after re-perfusion therapy and again at 6 months after the occurrence of MI. Patients were divided into two groups; hypertensive group and normotensive group. End-diastolic volume index (EDVI), end-systolic volume index (ESVI), and EF were compared between acute phase and 6 months after AMI in each group.


RESULTS
The hypertensive group showed a significant increase in both EDVI and ESVI after 6 months, whereas the normotensive group did not. In addition, there was no change in EF in the hypertensive group, whereas EF increased significantly after 6 months in the normotensive group. As a result, percent change in ESVI and EF showed significantly differences between the hypertensive group and normotensive group, whereas percent change in EDVI showed no significant difference between the two groups.


CONCLUSIONS
Antecedent hypertension interacts with ventricular remodeling after MI.
Kamimori
Kimio
K
Department of Internal Medicine and Cardiology, Osaka City University, Graduate School of Medicine, Japan. m5059985@msic.med.osaka-cu.ac.jp
Yoshiyama
Minoru
M
Shimada
Yoshihisa
Y
Iida
Hidetaka
H
Nakamura
Yasuhiro
Y
Uchida
Eiji
E
Yoshida
Ken
K
Jissho
Satoshi
S
Fukuda
Shota
S
Takeuchi
Kazuhide
K
Yoshikawa
Junichi
J
D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000503:physiopathology*; D013318:Stroke Volume; D020257:Ventricular Remodeling