Acquired resistance to imatinib in gastrointestinal stromal tumours caused by multiple KIT mutations.
Wardelmann
Eva
E
Department of Pathology, University of Bonn Medical Center, Germany. eva.wardelmann@ukb.unibonn.de <eva.wardelmann@ukb.unibonn.de>
Thomas
Nadja
N
Merkelbach-Bruse
Sabine
S
Pauls
Katharina
K
Speidel
Nicola
N
Büttner
Reinhard
R
Bihl
Heiner
H
Leutner
Claudia C
CC
Heinicke
Thomas
T
Hohenberger
Peter
P
D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001549:Benzamides; D019008:Drug Resistance, Neoplasm; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy* / Q000235:genetics*; D006801:Humans; D000068877:Imatinib Mesylate; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009362:Neoplasm Metastasis; D010879:Piperazines / Q000627:therapeutic use*; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics*; D011743:Pyrimidines / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D019009:Proto-Oncogene Proteins c-kit