title: Adenoma with gastric differentiation (so-called pyloric gland adenoma) in a heterotopic gastric corpus mucosa in the rectum.
abstract: In a 46-year-old man, a pedunculated rectal polyp measuring 3.0x3.0x2.0 cm was diagnosed histologically as a pyloric gland-type adenoma arising in heterotopic gastric corpus mucosa. The luminal site was covered by glands of the gastric foveolar type, displaying focal marked proliferation interpreted as low-grade intraepithelial neoplasia. A bidirectional gastric differentiation was found: most lower glandular structures showed positivity for the deep gastric mucin core protein Muc 6 and superficial positivity for gastric foveolar epithelium mucin core protein Muc 5AC. Pyloric gland adenoma has so far been described in one larger series only and a few case reports of the stomach, gallbladder, pancreatic duct and within heterotopic gastric corpus mucosa of the duodenal bulb. The present case report is the first case of a pyloric gland-type adenoma within a gastric corpus heterotopia of the rectal mucosa.
authors.affiliation: Institute of Pathology, Klinikum Bayreuth, Preuschwitzer Strasse 101, 95445 Bayreuth, Germany. vieth.lkpathol@uni-bayreuth.de
authors.forename: M
authors.initials: M
authors.lastname: Vieth
authors.forename: R
authors.initials: R
authors.lastname: Kushima
authors.forename: J P A
authors.initials: JP
authors.lastname: de Jonge
authors.forename: F
authors.initials: F
authors.lastname: Borchard
authors.forename: F
authors.initials: F
authors.lastname: Oellig
authors.forename: M
authors.initials: M
authors.lastname: Stolte
mesh_terms: D000236:Adenoma / Q000473:pathology*; D002455:Cell Division; D002828:Choristoma; D005753:Gastric Mucosa; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D007417:Intestinal Polyps / Q000737:chemistry / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D055271:Mucin 5AC; D055272:Mucin-6; D009077:Mucins / Q000032:analysis; D012004:Rectal Neoplasms / Q000737:chemistry / Q000473:pathology*; D013274:Stomach Neoplasms / Q000737:chemistry / Q000473:pathology
chemical_list: C524678:MUC5AC protein, human; C524734:MUC6 protein, human; D055271:Mucin 5AC; D055272:Mucin-6; D009077:Mucins