Application of stereocontrolled stepwise [3+2] cycloadditions to the preparation of inhibitors of alpha4beta1-integrin-mediated hepatic melanoma metastasis.
Zubia
Aizpea
A
Facultad de Química-Kimika Fakultatea, Universidad del País Vasco-Euskal Herriko Unibertsitatea, P. O. Box 1072, 20080 San Sebastián-Donostia, Spain.
Mendoza
Lorea
L
Vivanco
Silvia
S
Aldaba
Eneko
E
Carrascal
Teresa
T
Lecea
Begoña
B
Arrieta
Ana
A
Zimmerman
Tahl
T
Vidal-Vanaclocha
Fernando
F
Cossio
Fernando P
FP
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D018360:Crystallography, X-Ray; D003500:Cyclization; D015195:Drug Design; D039041:Integrin alpha4beta1 / Q000037:antagonists & inhibitors*; D008113:Liver Neoplasms / Q000188:drug therapy; D008297:Male; D008545:Melanoma / Q000188:drug therapy / Q000556:secondary; D051379:Mice; D008810:Mice, Inbred C57BL; D015394:Molecular Structure; D013237:Stereoisomerism
D000970:Antineoplastic Agents; D039041:Integrin alpha4beta1