title: Cobra snake venom reduces significantly tissue nucleic acid levels in human breast cancer.
abstract: OBJECTIVE
  To look into the feasibility of using cobra snake venom in suppressing breast cancer tissue through inhibition of nucleic acid synthesis.
  
  
  METHODS
  Samples of breast cancerous tissue, obtained from Atomic Energy Medical Center, LMCH, Jamshoro, incubated with varying concentrations of venom and without venom (as controls) were assayed for macromolecular (RNA and DNA) levels
  
  
  RESULTS
  No. change in the control samples while a prominent and significant fall in nucleic acid contents has been noted in venom treated tissues. Also, maximum effect was observed with 25ug/ml dose.
  
  
  CONCLUSIONS
  Snake venom strongly inhibited the formation of nucleic acids in the breast cancerous tissues. It may bring a fall in cell proliferation, thus there is hope that venom could be used as an anti-cancerous drug in the future.
authors.affiliation: Department of Pliysilogy, University of Sindh, Jamshoro.
authors.forename: Rukhsana
authors.initials: R
authors.lastname: Jokhio
authors.forename: Ahmed Farooq
authors.initials: AF
authors.lastname: Ansari
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy / Q000517:prevention & control*; D049109:Cell Proliferation / Q000187:drug effects*; D003603:Cytotoxins / Q000008:administration & dosage / Q000494:pharmacology*; D004546:Elapid Venoms / Q000008:administration & dosage / Q000494:pharmacology*; D017815:Elapidae; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D009696:Nucleic Acids / Q000187:drug effects*
chemical_list: D003603:Cytotoxins; D004546:Elapid Venoms; D009696:Nucleic Acids