title: Soluble cellular adhesion molecules, selectins, VEGF and endothelin-1 in patients with Wuchereria bancrofti infection and association with clinical status.
abstract: Lymphatic filariasis, a mosquito-transmitted disease commonly known as Bancroftian filariasis, is characterized by debilitating pathology linked to the progression of lymphoedema to a chronic state of elephantiasis. We performed longitudinal measurements of endothelial adhesion and angiogenic molecules in 63 Polynesian patients living in an hyperendemic focus of Wuchereria bancrofti. Decreased serum concentrations of soluble (s-) L selectin (CD62L) were noticed in sera of of patients with chronic conditions (hydrocele and elephantiasis). Chyluria was associated with increased vascular endothelial growth factor (VEGF) levels, whereas elephantiasis presented a high endothelin-1 (ET-1) profile. By contrast, increased serum concentrations of soluble intercellular (sICAM-1, CD54), but not of vascular cell (sVCAM-1, CD106), adhesion molecules were observed in sera of patients with bacterial lymphangitis used as controls. These trends are consistent with the increased permeability of vascular structures, a major clinical feature observed in acute lymphatic pathology (of bacterial or filarial origin), and of fundamental differences in the pathogenesis of hydrocele and elephantiasis. Using markers correlated with the clinical status (high ET-1 and VEGF levels for elephantiasis and chyluria, respectively; low CD62L levels for hydrocoele and elephantiasis) it should be possible to monitor disease progression in lymphatic filariasis.
authors.affiliation: Immunology Unit, Institut de Recherches Medicales Malarde, Papeete 98713 Tahiti (French Polynesia). pesterre@pasteur-cayenne.fr
authors.forename: P
authors.initials: P
authors.lastname: Esterre
authors.forename: C
authors.initials: C
authors.lastname: Plichart
authors.forename: M O
authors.initials: MO
authors.lastname: Huin-Blondey
authors.forename: L N
authors.initials: LN
authors.lastname: Nguyen
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D015415:Biomarkers; D002199:Capillary Permeability; D015815:Cell Adhesion Molecules / Q000097:blood*; D002648:Child; D002913:Chyle; D018450:Disease Progression; D004605:Elephantiasis, Filarial / Q000097:blood* / Q000469:parasitology / Q000473:pathology / Q000503:physiopathology*; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008205:Lymphangitis; D008297:Male; D008875:Middle Aged; D011114:Polynesia; D019087:Selectins / Q000097:blood*; D006848:Testicular Hydrocele; D014556:Urine; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*; D014958:Wuchereria bancrofti
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules; D016232:Endothelins; D019087:Selectins; D019010:Vascular Cell Adhesion Molecule-1; D042461:Vascular Endothelial Growth Factor A; D018799:Intercellular Adhesion Molecule-1