A non-random walk through the genome.
Recent publications on a wide range of eukaryotes indicate that genes showing particular expression patterns are not randomly distributed in the genome but are clustered into contiguous regions that we call neighborhoods. It seems probable that this organization is related to chromatin and the structure of the nucleus.
Oliver
Brian
B
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. oliver@helix.nih.gov
Misteli
Tom
T
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D045584:Chromosome Positioning; D005786:Gene Expression Regulation; D005796:Genes / Q000235:genetics*; D016678:Genome / Q000235:genetics*; D005810:Multigene Family / Q000235:genetics