Leptin and soluble leptin receptor levels in obese children in fasting and satiety states.
OBJECTIVE
To investigate the role of soluble leptin receptors in leptin resistance in obese children.


METHODS
Thirty-one obese children (16 boys and 15 girls) with a median age of 12.1 years and 15 age- and sex-matched controls were included in the study. Leptin and soluble leptin receptor levels were measured in fasting and satiety states.


RESULTS
Serum leptin levels were significantly higher and soluble leptin receptor levels were significantly lower in obese children compared to controls in fasting and satiety states. In obese children, there was a high and inverse correlation between leptin levels and soluble leptin receptor levels after fasting. Prepubertal obese children had lower leptin and higher soluble leptin, receptor levels compared to pubertal children in both states.


CONCLUSIONS
In this study, being the first to consider both fasting and satiety states, obese children were found to have higher leptin, but lower soluble leptin receptor levels, compared to controls. With these findings, it can be postulated that leptin resistance in obese children originates from a defect of soluble leptin receptor production.
Cinaz
Peyami
P
Department of Pediatric Endocrinology, Gazi University, Ankara, Turkey.
Bideci
Aysun
A
Camurdan
M Orhun
MO
Güven
Ayla
A
Gönen
Sevim
S
D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D005215:Fasting; D005260:Female; D006801:Humans; D020738:Leptin / Q000032:analysis* / Q000494:pharmacology*; D008297:Male; D009765:Obesity / Q000503:physiopathology*; D011956:Receptors, Cell Surface / Q000032:analysis*; D018121:Receptors, Cytokine; D054411:Receptors, Leptin; D012528:Satiety Response; D012995:Solubility
C515448:LEPR protein, human; D020738:Leptin; D011956:Receptors, Cell Surface; D018121:Receptors, Cytokine; D054411:Receptors, Leptin