[A new strategy to treat hyperhomocysteinemia].
Hyperhomocysteinemia is an independent risk factor for cardiovascular diseases. At present, the main therapeutic provision is to supply vitamin B(6), B(12) and folic acids, and the toxic and ill effect have been reported. Homocysteine, taurine, hydrogen sulfide and metallothionein are metabolic products from methionine. Homocysteine induces necrosis of endothelium, proliferation of vascular smooth muscle cells, proliferation and activation of vascular fibroblast cells and mitochondrial structural destruction and dysfunction of myocardium cells. Taurine, an end metabolic product of homocysteine, obviously reduces cardiovascular injury induced by homocysteine. The possible mechanism of antagonism by reducing oxidative stress and endoplasmic reticulum stress has been proved. Hydrogen sulfide, another end metabolic product of homocysteine, obviously reducing cardiovascular injury of homocysteine by scavenging oxidative radicals has been found. Metallothionein a derivant production of homocysteine metabolism, antagonism to homocysteine injury to cardiovascular system been discussed. Homocysteine, taurine, hydrogen sulfide and metallothionein, as a metabolic product of methionine, interactive antagonism and interactive biological influence have been reviewed. Induced endogenous or exogenous supply of taurine, hydrogen sulfide and metallothionein might resist cardiovascular injury induced by hyperhomocysteinemia. According to the methionine metabolic cycle, using endogenous antagonistic substances might be a new clinical preventive and treatment target of homocystinemia.
Geng
Bin
B
Institute of Cardiovascular, Peking University First Hospital, Beijing 100034, China.
Chang
Lin
L
Du
Jun-bao
JB
Tang
Chao-shu
CS
D000818:Animals; D002318:Cardiovascular Diseases / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D006862:Hydrogen Sulfide / Q000494:pharmacology / Q000627:therapeutic use; D020138:Hyperhomocysteinemia / Q000150:complications / Q000188:drug therapy*; D008668:Metallothionein / Q000494:pharmacology / Q000627:therapeutic use; D013654:Taurine / Q000494:pharmacology* / Q000627:therapeutic use
D013654:Taurine; D008668:Metallothionein; D006862:Hydrogen Sulfide