title: Protein transport and trafficking in Plasmodium falciparum-infected erythrocytes.
abstract: The human malarial parasite Plasmodium falciparum extensively modifies its host erythrocyte, and to this end, is faced with an interesting challenge. It must not only sort proteins to common organelles such as endoplasmic reticulum, Golgi and mitochondria, but also target proteins across the 'extracellular' cytosol of its host cell. Furthermore, as a member of the phylum Apicomplexa, the parasite has to sort proteins to novel organelles such as the apicoplast, micronemes and rhoptries. In order to overcome these difficulties, the parasite has created a novel secretory system, which has been characterized in ever-increasing detail in the past decade. Along with the 'hardware' for a secretory system, the parasite also needs to 'program' proteins to enable high fidelity sorting to their correct subcellular location. The nature of these sorting signals has remained until relatively recently, enigmatic. Experimental work has now begun to dissect the sorting signals responsible for correct subcellular targeting of parasite-encoded proteins. In this review we summarize the current understanding of such signals, and comment on their role in protein sorting in this organism, which may become a model for the study of novel protein trafficking mechanisms.
authors.affiliation: Hygiene Institute, Department of Parasitology, University of Heidelberg, Im Neuenheimer Feld 324, D-69120 Heidelberg, Germany.
authors.forename: J M
authors.initials: JM
authors.lastname: Przyborski
authors.forename: M
authors.initials: M
authors.lastname: Lanzer
mesh_terms: D000818:Animals; D000953:Antigens, Protozoan / Q000502:physiology; D004912:Erythrocytes / Q000378:metabolism* / Q000469:parasitology*; D006801:Humans; D016778:Malaria, Falciparum / Q000097:blood* / Q000469:parasitology*; D015388:Organelles / Q000502:physiology; D010455:Peptides / Q000502:physiology; D010963:Plasmodium falciparum / Q000502:physiology*; D021382:Protein Sorting Signals / Q000502:physiology*; D021381:Protein Transport / Q000502:physiology*; D015800:Protozoan Proteins / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
chemical_list: D000953:Antigens, Protozoan; D010455:Peptides; D021382:Protein Sorting Signals; D015800:Protozoan Proteins; C063362:QF116 antigen, Plasmodium falciparum; C085731:erythrocyte membrane protein 1, Plasmodium falciparum; C042968:knob protein, Plasmodium falciparum