Tight junctions, from tight intercellular seals to sophisticated protein complexes involved in drug delivery, pathogens interaction and cell proliferation.
Tight junctions (TJ) are intercellular seals that regulate the passage of ions and molecules through the paracellular pathway. This property allows epithelial and endothelial sheets to function as barriers between different body compartments. Although TJ were identified by electron microscopy since the 1950's, the analysis in recent years of their molecular composition, has depicted TJ as signaling complexes involved in a wide spectrum of physiological and pathological processes, such as cell growth and differentiation, cancer and metastasis, and pathogen interaction. This new knowledge has in turn given rise to novel strategies for enhancing the paracellular flux of poorly absorbed therapeutics.
Gonzalez-Mariscal
Lorenza
L
Center for Research and Advanced Studies (CINVESTAV), Department of Physiology, Biophysics and Neuroscience, México D.F., 07000, Mexico. lorenza@fisio.cinvestav.mx
Nava
Porfirio
P
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D007365:Intercellular Junctions / Q000187:drug effects / Q000382:microbiology* / Q000502:physiology; D046912:Multiprotein Complexes / Q000378:metabolism* / Q000502:physiology; D019108:Tight Junctions / Q000187:drug effects / Q000378:metabolism* / Q000382:microbiology* / Q000502:physiology
D046912:Multiprotein Complexes