title: [Expression of hypoxia-inducible factor-1alpha in middle ear cholesteatoma].
abstract: OBJECTIVE
  To explore the pathogenetic mechanism of middle ear cholesteatoma, the aim of this study is to detect the expression of Hypoxia-inducible factor-1alpha in middle ear cholesteatoma and normal external ear canal skin.
  
  
  METHODS
  We used the technology of immunohistochemistry to examine the expression of Hypoxia-inducible factor-1alpha in thirty-one middle ear cholesteatomas and ten samples of normal external ear canal skin.
  
  
  RESULTS
  The expression of HIF-1alpha was extremely higher in middle ear cholesteatomas than in normal external ear canal skin (P <0.05).
  
  
  CONCLUSIONS
  We found that the higher expression of Hypoxia-inducible factor-1alpha in middle ear cholesteatomas, so we think that Hypoxia-inducible factor-1alpha play an important role in the pathogenetic process of middle ear cholesteatoma, and hypoxia may be an incentive in the pathogenetic mechanism of middle ear cholesteatoma.
authors.affiliation: Department of Otolaryngology, Tongji Hospital, Wuhan, 430030, China. yangliu616@yahoo.com.cn
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Cui
authors.forename: Linlin
authors.initials: L
authors.lastname: Yu
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D018424:Cholesteatoma, Middle Ear / Q000209:etiology / Q000378:metabolism*; D004424:Ear Canal / Q000166:cytology; D004847:Epithelial Cells / Q000378:metabolism; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology; D051793:Hypoxia-Inducible Factor 1 / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged
chemical_list: D051793:Hypoxia-Inducible Factor 1