[Effect of ABO-incompatibility on allogeneic hematopoietic stem cell transplantation].
OBJECTIVE
To explore the effect of ABO mismatch on clinical characteristics in allogeneic hematopoietic stem cell transplantation (allo-HSCT).


METHODS
We retrospectively reviewed the clinical courses of 148 recipients of allo-HSCT from ABO-incompatible donors, of whom 85 ABO-compatible recipients were used as control group.


RESULTS
In ABO major incompatible group, the time of erythrocyte recovery after bone marrow transplantation (BMT) was delayed and more RBC transfusions were required as compared with ABO major incompatible peripheral blood stem cell transplantation (PBSCT). The incidence of acute graft versus host disease (aGVHD), cytomegalovirus (CMV) infection and survival had no significant difference between ABO-incompatible and ABO-compatible recipients for BMT, PBSCT and BMT+PBSCT.


CONCLUSIONS
ABO-incompatibility has no adverse effect on the outcome of HSCT. Allogeneic PBSCT can reduce red blood cell transfusion requirements and facilitate erythrocyte recovery as compared with BMT.
Bao
Li
L
Institute of Hematology, Peking University People's Hospital, Beijing 100044, China.
Huang
Xiao-jun
XJ
Liu
Kai-yan
KY
Xu
Lan-ping
LP
Chen
Huan
H
Zhang
Yao-chen
YC
Chen
Yu-hong
YH
Han
Wei
W
Lu
Dao-pei
DP
D000017:ABO Blood-Group System; D000293:Adolescent; D000328:Adult; D001787:Blood Group Incompatibility; D002648:Child; D005260:Female; D006086:Graft vs Host Disease / Q000453:epidemiology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014184:Transplantation, Homologous
D000017:ABO Blood-Group System