title: The cytokine gene polymorphisms in patients with chronic kidney graft rejection.
abstract: Chronic allograft rejection remains an important cause of morbidity after kidney transplantation. The aim of the study was to examine the association between IL-2, IL-6 and TNF-alpha promoter polymorphisms and chronic kidney allograft rejection. The study included 64 patients with long-term stable graft function and 62 with chronic allograft nephropathy. Among patients with chronic allograft nephropathy a statistically significant prevalence of the IL-6 CC genotype associated with low IL-6 expression was observed (p < 0.01, OR 3.18; 95% CI 1.27-8.15). There were no statistically significant differences in distribution of IL-2 and TNF-alpha genotypes between patients with stable graft function and chronic allograft rejection. The results of present study suggest that the genetically determined low IL-6 production may be the risk factor of chronic allograft nephropathy development.
authors.affiliation: Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, 70-111 Szczecin, Powst. Wielkopolskich 72, Poland. pawand@poczta.onet.pl
authors.forename: A
authors.initials: A
authors.lastname: Pawlik
authors.forename: L
authors.initials: L
authors.lastname: Domanski
authors.forename: J
authors.initials: J
authors.lastname: Rozanski
authors.forename: M
authors.initials: M
authors.lastname: Florczak
authors.forename: J
authors.initials: J
authors.lastname: Wrzesniewska
authors.forename: G
authors.initials: G
authors.lastname: Dutkiewicz
authors.forename: E
authors.initials: E
authors.lastname: Dabrowska-Zamojcin
authors.forename: B
authors.initials: B
authors.lastname: Gawronska-Szklarz
mesh_terms: D002908:Chronic Disease; D016207:Cytokines / Q000235:genetics* / Q000378:metabolism; D006084:Graft Rejection / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007376:Interleukin-2 / Q000235:genetics / Q000378:metabolism; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism; D016030:Kidney Transplantation; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism
chemical_list: D016207:Cytokines; D007376:Interleukin-2; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha