title: Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure-activity relationships.
abstract: A series of GPE analogues, including modifications at the Pro and/or Glu residues, was prepared and evaluated for their NMDA binding and neuroprotective effects. Main results suggest that the pyrrolidine ring puckering of the Pro residue plays a key role in the biological responses, while the preference for cis or trans rotamers around the Gly-Pro peptide bond is not important.
authors.affiliation: Instituto de Química Médica, Juan de la Cierva, 3, 28006 Madrid, Spain.
authors.forename: Sergio A
authors.initials: SA
authors.lastname: Alonso De Diego
authors.forename: Pilar
authors.initials: P
authors.lastname: Muñoz
authors.forename: Rosario
authors.initials: R
authors.lastname: González-Muñiz
authors.forename: Rosario
authors.initials: R
authors.lastname: Herranz
authors.forename: Mercedes
authors.initials: M
authors.lastname: Martín-Martínez
authors.forename: Edurne
authors.initials: E
authors.lastname: Cenarruzabeitia
authors.forename: Diana
authors.initials: D
authors.lastname: Frechilla
authors.forename: Joaquín
authors.initials: J
authors.lastname: Del Río
authors.forename: M Luisa
authors.initials: ML
authors.lastname: Jimeno
authors.forename: M Teresa
authors.initials: MT
authors.lastname: García-López
mesh_terms: D000818:Animals; D018698:Glutamic Acid / Q000378:metabolism; D007202:Indicators and Reagents; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship; D013570:Synaptic Membranes / Q000187:drug effects / Q000378:metabolism
chemical_list: D007202:Indicators and Reagents; D018696:Neuroprotective Agents; D009842:Oligopeptides; D018698:Glutamic Acid; C062053:glycyl-prolyl-glutamic acid