[Biological and evolutive spectrum of patients ANCA present].
OBJECTIVE
To analyse the immuno-biological profile of patients with antineutrophil cytoplasmic antibodies (ANCA) presents. This is a retrospective study of all ANCA positives cases from Nephrology Clinic Iasi during five years (1998-2003) on a cohort of 97 patients.


RESULTS
pANCA was positive in 28, cANCA was positive in 60 and the others had pANCA and cANCA. The diseases ANCA associated were: systemic vasculitis, rapidly progressive glomerulonephritis (GNRP), chronic renal failure of an unknown etiology. ANCA presence was associated with inflammatory syndrome in 83.5%, anemic syndrome in 71.1%. From the patients with renal disfunction (71.1%), half of them presented an increased level of creatinine (>6 mg%). Renal biopsy proven especially crescentic glomerulonephritis. The complications and the diseases were more frequent in cANCA cases.


CONCLUSIONS
cANCA presence is a negative prognosis factor in vasculitis; testing ANCA alone cannot be used to guide treatment.
Covic
A
A
Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi, Facultatea de Medicină, Clinica a IV-a Medicală-Nefrologie.
Mutică
Camelia
C
Ignat
Anamaria
A
Boaru
Iulia
I
Veisa
G
G
Enea
Maria
M
Covic
Maria
M
D000328:Adult; D000465:Algorithms; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D005260:Female; D005921:Glomerulonephritis / Q000097:blood / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014657:Vasculitis / Q000097:blood / Q000276:immunology*
D019268:Antibodies, Antineutrophil Cytoplasmic; D015415:Biomarkers