title: Impact of HMG-CoA reductase inhibitors for non-treated coronary segments.
abstract: BACKGROUND
  HMG-CoA reductase inhibitors (statin) have been reported to decrease coronary artery events in several angiographic studies. However, the mechanism by which statin achieve this is still unclear. The purpose of this study was to identify the effect of statin on coronary plaque using serial intravascular ultrasound analysis.
  
  
  RESULTS
  In this study, 48 patients with 48 lesions were divided into the prescribed group (statin group, n = 22) or the non-prescribed group (control group, n = 26) after successful coronary artery stenting. IVUS images were obtained at consecutive 5 mm segments, 5 mm from the proximal stent edge, immediately after stenting and at 6 months follow up. External elastic membrane volume (EEMV), lumen volume (LV) and plaque volume (PV) were measured using Simpson's method. The control group revealed no significant serial change in EEMV, PV, and LV during 6 months. On the other hand, the statin group revealed significant reductions of PV (35.5 +/- 12.7 mm3 vs 30.9 +/- 15.6 mm3, p = 0.001), resulting in increase of LV (47.7 +/- 19.8 mm3 vs 52.5 +/- 22.2 mm3, p = 0.003) without EEMV change (82.8 +/- 21.8 mm3 vs 83.9 +/- 25.7 mm3, p = NS). Although percent EEMV and percent LV changes showed no differences between the two groups, a larger percent PV change was observed in the statin group compared to the control group (control; 5.8 +/- 20.3% vs statin; -20.4 +/- 21.8%, p = 0.02).
  
  
  CONCLUSIONS
  The results of this study suggest that statin administration for 6 months reduces coronary plaque without positive vessel remodeling.
authors.affiliation: Department of Internal Medicine and Cardiology, Osaka City University, Graduate School of Medicine, Japan. m1153231@med.osaka-cu.ac.jp
authors.forename: Hiroki
authors.initials: H
authors.lastname: Nishioka
authors.forename: Kenei
authors.initials: K
authors.lastname: Shimada
authors.forename: Toru
authors.initials: T
authors.lastname: Kataoka
authors.forename: Makoto
authors.initials: M
authors.lastname: Hirose
authors.forename: Koichiro
authors.initials: K
authors.lastname: Asawa
authors.forename: Takao
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Hajime
authors.initials: H
authors.lastname: Yamashita
authors.forename: Shoichi
authors.initials: S
authors.lastname: Ehara
authors.forename: Kimio
authors.initials: K
authors.lastname: Kamimori
authors.forename: Tsunemori
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Yoshimura
authors.forename: Minoru
authors.initials: M
authors.lastname: Yoshiyama
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Takeuchi
authors.forename: Junichi
authors.initials: J
authors.lastname: Yoshikawa
mesh_terms: D000368:Aged; D016893:Carotid Stenosis / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000187:drug effects*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors