title: Corticolimbic blood flow in posttraumatic stress disorder during script-driven imagery.
abstract: BACKGROUND
  Functional neuroimaging experiments targeting personal recall of emotional events may help elucidate neural substrates underlying posttraumatic stress disorder (PTSD). Studies suggest that limbic and paralimbic function might be altered in PTSD, as compared with trauma-exposed control subjects; however, little is known about functional changes resulting from traumatic experience itself. The present study examined both PTSD-specific and trauma-specific regional cerebral blood flow (rCBF) patterns during script-driven imagery.
  
  
  METHODS
  Sixteen combat veterans with PTSD (PP); 15 combat veterans without PTSD (CC); and 14 healthy, aged-matched noncombat control subjects (NC) underwent [15O] H20 positron emission tomography (PET) scanning during script-driven imagery of emotionally evocative and neutral autobiographic events.
  
  
  RESULTS
  Differential patterns of activation were detected in amygdala and medial frontal cortex. Past trauma experience was associated with decreased amygdala activity (i.e., less activity than healthy control subjects); however, combat control subjects deactivated this region (i.e., greater activity to neutral scripts). All subjects deactivated medial frontal cortex; PTSD patients had greater rostral anterior cingulate (rACC) deactivation compared with control groups, who deactivated ventromedial prefrontal cortex (vmPFC).
  
  
  CONCLUSIONS
  Trauma-specific patterns may represent potential compensatory changes to traumatic reminders, while patterns observed only in the PTSD group may reflect neural substrates specific to PTSD pathophysiology.
authors.affiliation: Neuroscience Program, University of Michigan, Michigan, USA.
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Britton
authors.forename: K Luan
authors.initials: KL
authors.lastname: Phan
authors.forename: Stephan F
authors.initials: SF
authors.lastname: Taylor
authors.forename: Lorraine M
authors.initials: LM
authors.lastname: Fig
authors.forename: Israel
authors.initials: I
authors.lastname: Liberzon
mesh_terms: D000679:Amygdala / Q000098:blood supply / Q000000981:diagnostic imaging; D002540:Cerebral Cortex / Q000098:blood supply* / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004644:Emotions / Q000502:physiology; D005260:Female; D005712:Galvanic Skin Response; D006185:Habituation, Psychophysiologic; D006801:Humans; D008032:Limbic System / Q000098:blood supply* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation; D049268:Positron-Emission Tomography; D011569:Psychiatric Status Rating Scales; D013313:Stress Disorders, Post-Traumatic / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000523:psychology*