Hymeniacidon perleve associated bioactive bacterium pseudomonas sp. NJ6-3-1.
Among the marine bacteria isolated from cytotoxic sponge Hymeniacidon perleve, one strain NJ6-3-1 classified as Pseudomonas sp. showed both cytotoxic and antimicrobial activities. Fatty acid analysis indicated that the bacterial strain consists mainly of C16:1, C16:0, C18:1, C18:0, C15:0, C14:0. One unusual 9,10-cyclopropane-C17:0 fatty acid, and C26:0 also constitute as major component as well as the existence of squalene, the precursor of triterpenoids. The major metabolites in the culture broth were identified as alkaloids, including diketopiperazines and indole compounds, namely 3,6-diisopropylpiperazin-2,5-dione, 3-benzyl-3-isopropylpiperazin-2,5-dione, 3,6-bis-(2-methylpropyl)-piperazin-2,5-dione, indole-3-carboxaldehyde, indole-3-caroxylic acid methyl ester, indole-3-ethanol, and quinazoline-2,4-dione.
Zheng
Li
L
Institute of Oceanology, Chinese Academy of Sciences, Graduate School of The Chinese Academy of Science, Qingdao 266071, PR China.
Yan
Xiaojun
X
Xu
Jilin
J
Chen
Haimin
H
Lin
Wei
W
D000818:Animals; D005227:Fatty Acids / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D008386:Marine Biology; D013058:Mass Spectrometry; D011161:Porifera / Q000382:microbiology*; D011549:Pseudomonas / Q000737:chemistry / Q000302:isolation & purification / Q000502:physiology*
D005227:Fatty Acids