title: Churg-Strauss syndrome: high resolution CT and pathologic findings.
abstract: OBJECTIVE
  The purpose of this study was to evaluate high-resolution CT findings in 7 patients with Churg-Strauss syndrome and to compare the CT with the histopathologic findings.
  
  
  METHODS
  High-resolution CT scans of 7 asthmatic patients (4 women, 3 men, age range, 34-62 years, mean 49 years) with Churg-Strauss syndrome were reviewed by 2 observers. Histologic specimens of lung obtained at surgical (n = 3) or transbronchial (n = 3) biopsy or autopsy (n = 1) were reviewed by an expert lung pathologist. The diagnosis of Churg-Strauss was based on clinical, laboratory, and histologic findings.
  
  
  RESULTS
  Parenchymal and airway abnormalities included ground-glass opacities (n = 5), areas of air-space consolidation (n = 4), centrilobular nodules (n = 5), nodules 1-3 cm in diameter (n = 3), interlobular septal thickening (n = 4), bronchial wall thickening (n = 4), and areas of atelectasis (n = 1). Surgical biopsy (n = 3) and autopsy (n = 1) specimens demonstrated airspace disease in 3 patients, interlobular septal thickening in 3 patients, and airway abnormalities in 2 patients. Histologically, the airspace disease included eosinophilic pneumonia (n = 2) and small foci of organizing pneumonia (n = 1). The septal thickening was due to edema combined with numerous (n = 2) or few (n = 1) eosinophils. The airway abnormalities (n = 2) included muscle hypertrophy and large airway wall necrosis (n = 1) and eosinophilic infiltration of the airway walls (n = 1). Transbronchial biopsy (n = 3) demonstrated increased eosinophils.
  
  
  CONCLUSIONS
  The main high-resolution CT findings of Churg-Strauss syndrome consist of airspace consolidation or ground-glass opacities, septal lines, and bronchial wall thickening. These reflect the presence of eosinophilic infiltration of the airspaces, interstitium, and airways, and interstitial edema.
authors.affiliation: Department of Diagnostic Imaging, University Federal of São Paulo, Brazil.
authors.forename: Cleonice Isabela S
authors.initials: CI
authors.lastname: Silva
authors.forename: Nestor L
authors.initials: NL
authors.lastname: Müller
authors.forename: Kiminori
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Takeshi
authors.initials: T
authors.lastname: Johkoh
authors.forename: Sérgio A
authors.initials: SA
authors.lastname: Ajzen
authors.forename: Andrew
authors.initials: A
authors.lastname: Churg
mesh_terms: D000328:Adult; D001249:Asthma / Q000150:complications; D001706:Biopsy / Q000379:methods; D015267:Churg-Strauss Syndrome / Q000150:complications / Q000175:diagnosis* / Q000473:pathology*; D004562:Electrocardiography / Q000379:methods; D004804:Eosinophils / Q000000981:diagnostic imaging; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000175:diagnosis; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D010996:Pleural Effusion / Q000150:complications / Q000175:diagnosis; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*