title: [Protective effect of ligusticum chuanxiong phthalides on focai cerebral ischemia in rats and its related mechanism of action].
abstract: OBJECTIVE
  To study the protective effect of ligusticum chuanxiong phthalides on cerebral ischemia in rats and its related mechanism of action.
  
  
  METHODS
  Middle cerebral artery occlusion (MCAO) model, thrombosis formation, platelet aggregation and hemorrheological parameters were measured to evaluate the protective effect of ligusticum chuanxiong phthalides.
  
  
  RESULTS
  Ligusticum chuanxiong phthalides could markedly decrease the infarct size and behavior deficits score, inhibit the thrombus formation and platelet aggregation, ameliorate hemorrheological parameters with a dose-dependent manner in rats.
  
  
  CONCLUSIONS
  Ligusticum chuanxiong phthalides has protective effects on focal cerebral ischemia in rats, and its mechanism may be relevant to its inhibition of platelet-dependent thrombosis and amelioration of hemorrheological parameters.
authors.affiliation: School of Pharmacy, Shandong Yantai University, Shandong Engineering Research Center for Natural Drugs, Yamai 264003, China.
authors.forename: Jing-Wei
authors.initials: JW
authors.lastname: Tian
authors.forename: Feng-Hua
authors.initials: FH
authors.lastname: Fu
authors.forename: Wang-Lin
authors.initials: WL
authors.lastname: Jiang
authors.forename: Chao-Yun
authors.initials: CY
authors.lastname: Wang
authors.forename: Fang
authors.initials: F
authors.lastname: Sun
authors.forename: Tai-Ping
authors.initials: TP
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000302:isolation & purification / Q000494:pharmacology*; D001809:Blood Viscosity / Q000187:drug effects; D002545:Brain Ischemia / Q000097:blood / Q000473:pathology*; D004305:Dose-Response Relationship, Drug; D006400:Hematocrit; D020244:Infarction, Middle Cerebral Artery / Q000097:blood / Q000473:pathology; D030004:Ligusticum / Q000737:chemistry*; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D020246:Venous Thrombosis / Q000517:prevention & control*
chemical_list: D001572:Benzofurans; D018696:Neuroprotective Agents; C082022:phthalide