Colonization of human immunodeficiency virus-infected outpatients in Taiwan with Candida species.
To understand the Candida colonization of human immunodeficiency virus (HIV)-infected outpatients in Taiwan, we have conducted a prospective cohort study of Candida colonization and its risk factors at the National Taiwan University Hospital from 1999 to 2002. More than 50% of the patients were colonized with Candida species, and 12% developed symptomatic candidiasis. Patients colonized with fluconazole-resistant strains of Candida species had a higher prevalence of candidiasis than those colonized with susceptible strains. Our analysis found that antibiotic treatment and lower CD4(+) counts (<200 cells/mm(3)) increased the rate of oropharyngeal candidiasis in HIV-infected patients, while antiretroviral therapy protected patients from the development of candidiasis.
Hung
Chien-Ching
CC
Division of Infectious Diseases, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Yang
Yun-Liang
YL
Lauderdale
Tsai-Ling
TL
McDonald
L Clifford
LC
Hsiao
Chin-Fu
CF
Cheng
Hsiao-Hsu
HH
Ho
Yong An
YA
Lo
Hsiu-Jung
HJ
D017088:AIDS-Related Opportunistic Infections / Q000382:microbiology*; D000935:Antifungal Agents / Q000494:pharmacology; D002175:Candida / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification* / Q000472:pathogenicity; D002180:Candidiasis, Oral / Q000382:microbiology*; D015331:Cohort Studies; D025141:Drug Resistance, Fungal; D015725:Fluconazole / Q000494:pharmacology; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1; D006801:Humans; D008826:Microbial Sensitivity Tests; D009960:Oropharynx / Q000382:microbiology*; D011446:Prospective Studies; D012307:Risk Factors; D013048:Specimen Handling / Q000379:methods
D000935:Antifungal Agents; D015725:Fluconazole