title: Synchronous collecting duct carcinoma and papillary renal cell carcinoma: a case report and review of the literature.
abstract: The coexistence of multiple and synchronous primary neoplasms in the same organ (including kidney) has only rarely been described in the literature. We herein present a case of collecting duct carcinoma (CDC) combined with papillary renal carcinoma (RCC) having a 57-month disease-free survival CDC is a rather rare and aggressive neoplasm of the kidney. Sharing probably the same embryological origin, synchronous or metachronous association with in situ orpapillary transitional cell carcinoma (TCC) may be found; association with RCC has been only once reported in the literature. The high incidence of c-erbB-2 oncogene amplification in CDC further characterizes this tumor as a separate entity from renal cell carcinoma, and shows some genetic characteristics in common with TCC. The histological diagnosis of Bellini CDC can be confirmed by the positive immunohistochemical staining with a collecting duct marker and distal tubule marker and negative staining with a proximal tubule marker.
authors.affiliation: European Institute of Oncology, Milan, Italy. victor.matei@ieo.it
authors.forename: Deliu-Victor
authors.initials: DV
authors.lastname: Matei
authors.forename: Bernardo
authors.initials: B
authors.lastname: Rocco
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Varela
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Verweij
authors.forename: Epifanio
authors.initials: E
authors.lastname: Scardino
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Renne
authors.forename: Ottavio
authors.initials: O
authors.lastname: De Cobelli
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000150:complications* / Q000175:diagnosis*; D002292:Carcinoma, Renal Cell / Q000150:complications* / Q000175:diagnosis*; D018572:Disease-Free Survival; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000473:pathology; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000473:pathology; D007685:Kidney Tubules, Collecting / Q000473:pathology*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases