[Comparative study on effects of puerarin and granulocyte colony-stimulating factor in treating acute myocardial infarction].
OBJECTIVE
To compare the effects of puerarin and granulocyte colony-stimulating factor (G-CSF) in treating acute myocardial infarction (AMI) and on the size of infarcted area and cytokines.


METHODS
Seventy-nine patients with anterior AMI were randomly divided into three groups, they were treated with conventional Western medical treatment, but to the puerarin group (PG) and the G-CSF group (GCG) puerarin and G-CSF was given additionally, respectively. The infarcted size, plasma G-CSF, matrix metalloproteinase-9 (MMP-9), serum interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) were detected before and after treatment.


RESULTS
The infarcted size was positively correlated to the levels of G-CSF, MMP-9, IL-6 and TNF-alpha before treatment ( r = 0.45, 0.42, 0.44 and 0.42, P<0.01 ). The infarcted size in the PG and the GCG decreased on the 28th day (P<0.01), the level of G-CSF, MMP-9, IL-6 and TNF-alpha in the PG on the 7th day all decreased (P<0.05), but these indexes in the GCG increased (P<0.05), while those in the control group were unchanged (P>0.05).


CONCLUSIONS
Puerarin and G-CSF are effective in decreasing infarcted size, but their effects on cytokines are different entirely.
Xiao
Li-zhong
LZ
Department of Cardiovascular Diseases, Yuebei People's Hospital of Guangdong Province, Shaoguan, Guangdong.
Gao
Ling-jun
LJ
Ma
Shao-chun
SC
D000368:Aged; D018952:Antigens, CD34 / Q000378:metabolism; D004359:Drug Therapy, Combination; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D007529:Isoflavones / Q000627:therapeutic use*; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D008517:Phytotherapy; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D018952:Antigens, CD34; D015850:Interleukin-6; D007529:Isoflavones; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D020780:Matrix Metalloproteinase 9; C033607:puerarin