title: Periodic motor cortical excitability changes associated with PSDs of EEG in Creutzfeldt-Jakob disease (CJD).
abstract: OBJECTIVE
  To assess the temporal relationship between excitability changes of the motor cortex and periodic synchronous discharges (PSDs) of electroencephalograms (EEGs) in Creutzfeld-Jakob disease (CJD) patients.
  
  
  METHODS
  In four patients with classical type CJD we gave transcranial magnetic stimulation (TMS) randomly in time while simultaneously recording their EEGs and electromyograms (EMGs). The intensity of TMS was fixed to evoke 0.3-0.5 mV EMG in the abductor pollicis brevis muscle (APB) during periods in which there were no PSDs. We assessed the relation between the timing of TMS and EMG response sizes when PSD appeared in EEGs. The time interval between TMS and the onset of preceding PSD was plotted against the amplitude of acquired motor evoked potentials (MEPs).
  
  
  RESULTS
  The amplitude of MEP was at a minimum when the TMS pulse was given just after the beginning of PSD and was maximal when given just before the onset of the next PSD. As a result, the size of MEP amplitude periodically changed and was phase-locked to the PSD, though its cycle slightly preceded that of PSD.
  
  
  CONCLUSIONS
  Our study has demonstrated that excitability changes in motor cortex are closely related to the occurrence of PSD.
  
  
  CONCLUSIONS
  It has been revealed for the first time that motor cortical excitability is related to PSD cycle.
authors.affiliation: Department of Neurology, Division of Neuroscience, Graduate School of Medicine, University of Tokyo, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Sakuishi
authors.forename: Ritsuko
authors.initials: R
authors.lastname: Hanajima
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kanazawa
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Ugawa
mesh_terms: D000368:Aged; D007562:Creutzfeldt-Jakob Syndrome / Q000503:physiopathology*; D004558:Electric Stimulation; D004569:Electroencephalography; D004576:Electromyography; D019054:Evoked Potentials, Motor / Q000502:physiology*; D005260:Female; D006801:Humans; D008280:Magnetics; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology*