title: Biochemical and cellular mechanisms of mammalian CDK inhibitors: a few unresolved issues.
abstract: p21 and p16, first identified as two small molecular weight proteins in CDK and cyclin immunocomplexes, represent two distinct families constituting a total of seven CDK inhibitors in mammalian cells. The physiological functions of these genes are believed to be broadly involved in connecting various cellular pathways to cell cycle control. Extensive studies over the past 10 years have led to a fairly clear understanding of their biochemical and cellular mechanisms and have also left some unresolved and controversial issues.
authors.affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA.
authors.forename: Xin-Hai
authors.initials: XH
authors.lastname: Pei
authors.forename: Yue
authors.initials: Y
authors.lastname: Xiong
mesh_terms: D000818:Animals; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics / Q000502:physiology; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000494:pharmacology*
chemical_list: D019941:Cyclin-Dependent Kinase Inhibitor p16; D004791:Enzyme Inhibitors; D018844:Cyclin-Dependent Kinases