Tumour targeting: biological factors and formulation advances in injectable lipid nanoparticles.
Cancer chemotherapeutic agents are often administered systemically. Following systemic administration, numerous biological factors associated with the tumours influence the delivery of the drugs to the tumours. These factors have been extensively studied for the last 2 decades. The influence of these biological factors has brought about a drastic change in the design of drug delivery systems to solid tumours. This review discusses the various biological factors influencing drug delivery to tumours and the subsequent development of injectable delivery systems (i.e., lipid-based nanoparticles (SLNs)) for adequate delivery of drug to solid tumours.
Shenoy
V S
VS
New Drug Delivery Systems Laboratory, Pharmacy Department, Donors Plaza, Opp. University Main Office, M S University of Baroda, Fatehgunj, Vadodara-390002, India.
Vijay
I K
IK
Murthy
R S R
RS
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001685:Biological Factors / Q000378:metabolism*; D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems; D005079:Excipients; D006801:Humans; D007267:Injections; D008055:Lipids; D008081:Liposomes; D049329:Nanostructures; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000378:metabolism*; D020442:Poloxamer
D000970:Antineoplastic Agents; D001685:Biological Factors; D005079:Excipients; D008055:Lipids; D008081:Liposomes; D020442:Poloxamer