title: An azepanone-based inhibitor of human cathepsin K with improved oral bioavailability in the rat and the monkey.
authors.affiliation: Departments of Medicinal Chemistry, GlaxoSmithKline, Collegeville, Pennsylvania 19426, USA. Robert_W_Marquis@GSK.com
authors.forename: Robert W
authors.initials: RW
authors.lastname: Marquis
authors.forename: Keith W
authors.initials: KW
authors.lastname: Ward
authors.forename: Theresa
authors.initials: T
authors.lastname: Roethke
authors.forename: Brian R
authors.initials: BR
authors.lastname: Smith
authors.forename: Yu
authors.initials: Y
authors.lastname: Ru
authors.forename: Dennis S
authors.initials: DS
authors.lastname: Yamashita
authors.forename: Thaddeus A
authors.initials: TA
authors.lastname: Tomaszek
authors.forename: Peter D
authors.initials: PD
authors.lastname: Gorycki
authors.forename: H Y
authors.initials: HY
authors.lastname: Cheng
authors.forename: Ian E
authors.initials: IE
authors.lastname: James
authors.forename: George B
authors.initials: GB
authors.lastname: Stroup
authors.forename: Michael W
authors.initials: MW
authors.lastname: Lark
authors.forename: Maxine
authors.initials: M
authors.lastname: Gowen
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Veber
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001381:Azepines / Q000493:pharmacokinetics* / Q000494:pharmacology; D001682:Biological Availability; D056657:Cathepsin K; D002403:Cathepsins / Q000378:metabolism*; D015853:Cysteine Proteinase Inhibitors / Q000493:pharmacokinetics* / Q000494:pharmacology; D006801:Humans; D051381:Rats
chemical_list: D001381:Azepines; D015853:Cysteine Proteinase Inhibitors; D002403:Cathepsins; C534130:CTSK protein, human; D056657:Cathepsin K; C534133:Ctsk protein, rat