title: Weekly variation of home and ambulatory blood pressure and relation between arterial stiffness and blood pressure measurements in community-dwelling hypertensives.
abstract: Although blood pressure (BP) is a major determinant of pulse wave velocity (PWV), some treatments have independent effects on BP and arterial stiffness. Although both ambulatory BP (ABP) and self-measured BP at home (HBP) have become important measures for the diagnosis and management of hypertension, single day recordings may be insufficient for a proper diagnosis of hypertension or the evaluation of treatment efficacy. To evaluate weekly variations in BP using 7-day HBP and 7-day ABP monitoring and to determine the relation between arterial stiffness and BP measurements in community-dwelling patients with hypertension. We enrolled 68 community-dwelling hypertensive subjects in this study. Significant weekly variations in systolic blood pressure (SBP) and diastolic blood pressure (DBP) were found in the awake ABP data (p < .01, respectively), while no significant weekly variations in the asleep ABP or the morning and evening HBP data were observed. In untreated subjects, significant correlations were obtained between the brachial-ankle PWV and the average awake SBP, the average asleep SBP and the average SBP measured by HBP in the evening. In treated subjects, only the average SBP measured by HBP in the morning was significantly correlated with the baPWV. Differences in the weekly variations in BP were observed between HBP and ABP monitoring. In addition, the morning systolic HBP was not correlated with arterial stiffness in untreated subjects with hypertension but was correlated in treated subjects. Relations between the morning HBP and arterial stiffness might be attributed to morning surges in BP and/or trough levels of antihypertensive drugs.
authors.affiliation: Department of Medicine, Tokyo Women's Medical University, Daini Hospital, Tokyo, Japan. shougo17@gb3.so-net.ne.jp
authors.forename: Shougo
authors.initials: S
authors.lastname: Murakami
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Otsuka
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kubo
authors.forename: Makoto
authors.initials: M
authors.lastname: Shinagawa
authors.forename: Osamu
authors.initials: O
authors.lastname: Matsuoka
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamanaka
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Nunoda
authors.forename: Shin-Ichiro
authors.initials: S
authors.lastname: Ohkawa
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kitaura
mesh_terms: D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012424:Rural Population; D012720:Severity of Illness Index; D014655:Vascular Resistance / Q000502:physiology*