title: Activation of cytotoxic lymphocytes in patients with scrub typhus.
abstract: Thai patients with scrub typhus caused by the intracellular pathogen Orientia tsutsugamushi displayed elevated plasma concentrations of granzymes A and B, interferon-gamma (IFN)-gamma-inducible protein 10, and monokine induced by IFN-gamma. These data suggest that activation of cytotoxic lymphocytes is part of the early host response to scrub typhus.
authors.affiliation: Laboratory of Experimental Internal Medicine and Department of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
authors.forename: Maaike
authors.initials: M
authors.lastname: de Fost
authors.forename: Wirongrong
authors.initials: W
authors.lastname: Chierakul
authors.forename: Kriangsak
authors.initials: K
authors.lastname: Pimda
authors.forename: Arjen M
authors.initials: AM
authors.lastname: Dondorp
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: White
authors.forename: Tom
authors.initials: T
authors.lastname: Van der Poll
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D018925:Chemokines / Q000276:immunology; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D012612:Scrub Typhus / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
chemical_list: D018925:Chemokines