Synthesis of heteroaryl 1,2-diketones.
Reactions of lithiated heteroaryl- (or aryl-) methylbenzotriazoles 4a-e with heteroaryl (or aryl) esters 5a-f give alpha-benzotriazolyl ketones 6a-n in average yields of 90-95%. Oxidation of ketones 6a-l in aqueous DMSO in the presence of oxygen and sodium bicarbonate gave heteroaryl- (aryl-) 1,2-ethanediones 7a-l in average yields of 60-80%.
Katritzky
Alan R
AR
Department of Chemistry, Center for Heterocyclic Compounds, University of Florida, Gainesville, FL 32611-7200, USA. katritzky@chem.ufl.edu
Zhang
Dazhi
D
Kirichenko
Kostyantyn
K