title: twilight; a Bioconductor package for estimating the local false discovery rate.
abstract: twilight is a Bioconductor compatible package for analysing the statistical significance of differentially expressed genes. It is based on the concept of the local false discovery rate (FDR), a generalization of the frequently used global FDR. twilight implements the heuristic search algorithm for estimating the local FDR introduced in our earlier work. In addition to the raw significance measures, it produces diagnostic plots, which provide insight into the extent of differential expression across genes.
  
  
  BACKGROUND
  http://www.bioconductor.org
  
  
  BACKGROUND
  stefanie.scheid@molgen.mpg.de
  
  
  BACKGROUND
  Please visit our software webpage on http://compdiag.molgen.mpg.de/software.
authors.affiliation: Max Planck Institute for Molecular Genetics, Department of Computational Molecular Biology, Ihnestrasse 63-73, D-14195 Berlin, Germany. stefanie.scheid@molgen.mpg.de
authors.forename: Stefanie
authors.initials: S
authors.lastname: Scheid
authors.forename: Rainer
authors.initials: R
authors.lastname: Spang
mesh_terms: D000465:Algorithms; D003196:Computer Graphics; D003198:Computer Simulation; D005189:False Positive Reactions; D020869:Gene Expression Profiling / Q000379:methods*; D008957:Models, Genetic; D015233:Models, Statistical; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D012984:Software; D014584:User-Computer Interface