Novel acrylonitrile-based copolymers containing phospholipid moieties: synthesis and characterization.
Novel acrylonitrile-based copolymers containing phospholipid moieties were synthesized by a three-step process, which included the copolymerization of acrylonitrile and 2-hydroxyethyl methacrylate (HEMA) in water and the reaction of the resulting poly[acrylonitrile-co-(2-hydroxyethyl methacrylate)]s (PANCHEMA) with 2-chloro-2-oxo-1,3,2-dioxaphospholane (COP) followed by the ring-opening reaction of COP with trimethylamine. The chemical structure of PANCHEMA and the phospholipid-containing acrylonitrile-based copolymers (PLCANCP) was analyzed with FT-IR spectroscopy, (1)H and (31)P NMR, and XPS. Surface properties of the studied copolymers were evaluated by the pure water contact angle, protein adsorption and platelets adhesion measurements. The water contact angle measured by sessile drop method decreased for the polymers in the following sequence: PAN, PANCHEMA, and PLCANCP. The adsorption amount of bovine serum albumin and the adhesive number of platelet followed the same decline sequence. These results demonstrate that the biocompatibility of the acrylonitrile-based copolymer membranes could be improved efficiently by the introduction of phospholipid moieties.
Huang
Xiao-Jun
XJ
Institute of Polymer Science, Zhejiang University, Hangzhou 310027, P. R. China.
Xu
Zhi-Kang
ZK
Wan
Ling-Shu
LS
Wang
Zhen-Gang
ZG
Wang
Jian-Li
JL
D000181:Acrylonitrile / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D001792:Blood Platelets / Q000737:chemistry; D002417:Cattle; D002448:Cell Adhesion; D006801:Humans; D010743:Phospholipids / Q000138:chemical synthesis / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*
D001672:Biocompatible Materials; D010743:Phospholipids; D011108:Polymers; D000181:Acrylonitrile