B-type natriuretic peptide in patients with clinical hyperthyroidism.
OBJECTIVE
To investigate the level and clinical significance of plasma B-type natriuretic peptide (BNP) in patients with hyperthyroidism.


METHODS
Plasma BNP was measured in 32 healthy subjects and 67 patients with clinical hyperthyroidism. Left ventricular anatomy and function was assessed with echocardiography.


RESULTS
The average BNP in hyperthyroid patients was higher than that in healthy subjects (186+/-140 vs 34+/-17 ng/l, p =0.001). The increase in BNP was mainly found in hyperthyroid patients who had clinical and echocardiographic evidence of left ventricular dysfunction (250+/-190 ng/l). The BNP level in patients with hyperthyroidism, but with normal left ventricular function, was similar to that of the controls (37+/-17 vs 34+/-17, ng/l, p>0.05). Multi-regression analysis showed that left atrial diameter and left ventricular ejection fraction were independently associated with the plasma levels of BNP.


CONCLUSIONS
there is a significant elevation in plasma BNP in patients with hyperthyroidism; the increase is largely due to hyperthyroidism-induced left ventricular dysfunction. Measurements of plasma BNP may help to detect heart failure in patients with clinical hyperthyroidism.
Wei
T
T
Department of Cardiology, Lishui City Central Hospital, Zhejiang Province, the People's Republic of China.
Zeng
C
C
Tian
Y
Y
Chen
Q
Q
Wang
L
L
D000328:Adult; D000368:Aged; D015415:Biomarkers; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011446:Prospective Studies; D013963:Thyroid Hormones / Q000097:blood; D016277:Ventricular Function, Left / Q000502:physiology
D015415:Biomarkers; D013963:Thyroid Hormones; D020097:Natriuretic Peptide, Brain