Urinary excretion of liver fatty acid-binding protein in health-check participants.
BACKGROUND
Messenger RNA of liver fatty acid-binding protein (L-FABP) is expressed in proximal tubules of the kidney, and a certain amount is excreted into urine. We analyzed factors relating to the urinary L-FABP excretion in health-check participants.


METHODS
We measured L-FABP in the first morning urine by ELISA in 715 men and 193 women 30-79 years of age who entered a 2-day hospitalized health checkup program. In addition to the routine physical examination and laboratory tests, plasma high-sensitivity C-reactive protein (HSCRP) was assayed.


RESULTS
In 150 healthy subjects, urinary L-FABP averaged 3.6 +/- 0.2 microg/g creatinine, whereas the values were significantly increased in patients with hypertension (5.2 +/- 0.4, P = 0.010), diabetes mellitus (5.5 +/- 0.5, P < 0.001), and chronic hepatitis (5.8 +/- 1.0, P = 0.022). Urinary L-FABP excretion was significantly greater in women than in men when the value was related to creatinine. In regression analysis in men, urinary L-FABP was positively correlated with fasting plasma glucose (r = 0.103, P = 0.033) and plasma HSCRP (r = 0.135, P = 0.006).


CONCLUSIONS
It is suggested that renal production and urinary excretion of L-FABP are increased in situations in which arteriosclerosis is promoted, such as hypertension, diabetes mellitus, and cardiovascular inflammation.
Ishimitsu
Toshihiko
T
Department of Cardiovascular Medicine, Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, Japan. isimitu@dokkyomed.ac.jp
Ohta
Satoshi
S
Saito
Mayumi
M
Teranishi
Megumi
M
Inada
Hideki
H
Yoshii
Masayoshi
M
Minami
Junichi
J
Ono
Hidehiko
H
Hikawa
Akihisa
A
Shibata
Norio
N
Sugaya
Takeshi
T
Kamijo
Atsuko
A
Kimura
Kenjiro
K
Ohrui
Masami
M
Matsuoka
Hiroaki
H
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis; D002352:Carrier Proteins / Q000652:urine*; D002908:Chronic Disease; D003404:Creatinine / Q000652:urine; D003920:Diabetes Mellitus / Q000652:urine; D005215:Fasting / Q000097:blood; D050556:Fatty Acid-Binding Proteins; D005260:Female; D006505:Hepatitis / Q000652:urine; D006760:Hospitalization; D006801:Humans; D006973:Hypertension / Q000652:urine; D008297:Male; D008875:Middle Aged; D010808:Physical Examination; D012044:Regression Analysis; D012737:Sex Factors
D001786:Blood Glucose; D002352:Carrier Proteins; C493319:FABP1 protein, human; D050556:Fatty Acid-Binding Proteins; D002097:C-Reactive Protein; D003404:Creatinine