title: Relationship between plasma leptin, insulin and tumor necrosis factor alpha in obese children.
abstract: OBJECTIVE
  1. To evaluate the relationship between plasma leptin and TNFalpha concentrations in obese children and to assess the differences between hyperinsulinemic and normoinsulinemic groups. 2. To evaluate the relationship between plasma leptin and insulin levels in obese children. 3. To investigate the TNFalpha G308A mutation in obese children.
  
  
  METHODS
  Body mass index (BMI), fasting plasma glucose and insulin levels, oral glucose tolerance test results, homeostasis model assessment of insulin resistance (HOMA-IR) results, and plasma leptin and TNFalpha concentrations were evaluated in obese children (n = 45) and age- and gender-matched, lean healthy controls (n = 40).
  
  
  RESULTS
  In obese children the fasting insulin, HOMA-IR results, plasma leptin and TNFalpha concentrations were significantly higher than in controls (p <0.05). Furthermore, obese females showed higher plasma leptin and insulin resistance compared to obese males. While plasma leptin, TNFalpha levels and HOMA-IR results were similar in the prepubertal and pubertal groups, insulin levels were significantly higher in the pubertal group. Plasma leptin and TNFalpha concentrations were similar in hyperinsulinemic and normoinsulinemic obese children. In control children, plasma leptin concentrations showed a positive correlation with BMI, age, fasting insulin and HOMA-IR results. In obese children, plasma leptin levels did not correlate with BMI, fasting insulin or TNFalpha.
  
  
  CONCLUSIONS
  Plasma leptin concentrations did not show any correlation with TNFalpha levels in obese children. Furthermore, plasma leptin and TNFalpha concentrations were similar in hyperinsulinemic and normoinsulinemic obese children.
authors.affiliation: Department of Pediatric Endocrinology, Ankara University School of Medicine, Ankara, Turkey. zehraaycan67@hotmail.com
authors.forename: Zehra
authors.initials: Z
authors.lastname: Aycan
authors.forename: Merih
authors.initials: M
authors.lastname: Berberoğlu
authors.forename: Gönül
authors.initials: G
authors.lastname: Ocal
authors.forename: Olcay
authors.initials: O
authors.lastname: Evliyaoglu
authors.forename: Pelin
authors.initials: P
authors.lastname: Adiyaman
authors.forename: Gülhis
authors.initials: G
authors.lastname: Deda
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Caksen
authors.forename: Nejat
authors.initials: N
authors.lastname: Akar
authors.forename: Ceren
authors.initials: C
authors.lastname: Karahan
authors.forename: Peyami
authors.initials: P
authors.lastname: Cinas
authors.forename: Aysun
authors.initials: A
authors.lastname: Bideci
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D005215:Fasting; D005260:Female; D006706:Homeostasis; D006801:Humans; D007004:Hypoglycemic Agents / Q000097:blood*; D007328:Insulin / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008297:Male; D009765:Obesity / Q000276:immunology* / Q000503:physiopathology*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha