title: Multi-detector CT enterography with iso-osmotic mannitol as oral contrast for detecting small bowel disease.
abstract: OBJECTIVE
  To assess the feasibility and usefulness of multi-detector CT enterography with orally administered iso-osmotic mannitol as negative contrast in demonstrating small bowel disease.
  
  
  METHODS
  Thirteen volunteers and 38 patients with various kinds of small bowel disease were examined. We administered about 1 500 mL iso-osmotic mannitol as negative contrast agent and then proceeded with helical CT scanning on a Siemens Sensation 16 scanner. All volunteers and patients were interviewed about their tolerance of the procedure. Two radiologists post-processed imaging data with MPR, thin MIP, VRT and INSPACE when necessary and then interpreted the scans, and adequacy of luminal distention was evaluated on a four-point scale. Demonstration of features of various kinds of small bowel disease was analyzed.
  
  
  RESULTS
  The taste of iso-osmotic mannitol is good (slightly sweet) and acceptable by all. Small bowel distention was excellent and moderate in most volunteers and patients. CT features of many kinds of diseases such as tumors, Crohn's disease,and small bowel obstruction, etc. were clearly displayed.
  
  
  CONCLUSIONS
  Multi-detector CT enterography with iso-osmotic mannitol as negative contrast to distend the small bowel is a simple, rapid, noninvasive and effective method of evaluating small bowel disease.
authors.affiliation: Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, Zhejiang Province, China. wujinghzyy@163.com
authors.forename: Lian-He
authors.initials: LH
authors.lastname: Zhang
authors.forename: Shi-Zheng
authors.initials: SZ
authors.lastname: Zhang
authors.forename: Hong-Jie
authors.initials: HJ
authors.lastname: Hu
authors.forename: Min
authors.initials: M
authors.lastname: Gao
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.forename: Qian
authors.initials: Q
authors.lastname: Cao
authors.forename: Qiao-Wei
authors.initials: QW
authors.lastname: Zhang
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003424:Crohn Disease / Q000000981:diagnostic imaging*; D004234:Diuretics, Osmotic; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007421:Intestine, Small / Q000000981:diagnostic imaging*; D007511:Ischemia / Q000000981:diagnostic imaging; D008297:Male; D008353:Mannitol; D008875:Middle Aged; D000267:Tissue Adhesions / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D004234:Diuretics, Osmotic; D008353:Mannitol