Error-prone DNA repair and translesion synthesis: focus on the replication fork.
Dean Rupp and Paul Howard-Flanders showed that, following exposure to ultraviolet light, bacteria deficient in nucleotide excision repair synthesised DNA with minimal delay and in pieces roughly the size of the distances between pyrimidine dimmers. The discontinuities or gaps between these pieces were subsequently sealed. This led directly to the hypothesis of translesion synthesis.
Bridges
Bryn A
BA
Genome Damage and Stability Center, University of Sussex, Falmer, Brighton BN1 9RQ, UK. b.a.bridges@sussex.ac.uk
D010582:Bacteriophage lambda / Q000235:genetics* / Q000528:radiation effects; D004247:DNA / Q000302:isolation & purification / Q000378:metabolism* / Q000528:radiation effects; D004249:DNA Damage; D004260:DNA Repair; D004261:DNA Replication; D004926:Escherichia coli / Q000235:genetics* / Q000528:radiation effects; D011740:Pyrimidine Dimers / Q000032:analysis; D013014:SOS Response, Genetics; D014466:Ultraviolet Rays
D011740:Pyrimidine Dimers; D004247:DNA