Bioactive natural products from marine invertebrates and associated fungi.
Marine natural products with their unique structural features and pronounced biological activities continue to provide lead structures in the search for new drugs from nature. Invertebrates such as sponges, tunicates, mollusks and others that are either sessile or slow moving and mostly lack morphological defense structures have so far provided the largest number of marine-derived secondary constituents including some of the most interesting drug candidates. This review highlights recent research findings of our group related to natural products from marine invertebrates. Areas that are covered include ecological functions of secondary constituents from sponges against predatory fish, the search for new pharmacologically active constituents from sponges and tunicates, and sponge-associated fungi as an evolving source for new bioactive natural products.
Proksch
P
P
Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstr 1, 40225 Düsseldorf, Germany.
Ebel
R
R
Edrada
R A
RA
Wray
V
V
Steube
K
K
D000470:Alkaloids / Q000378:metabolism; D000818:Animals; D044822:Biodiversity; D001688:Biological Products; D001709:Biotechnology; D005656:Fungal Proteins / Q000378:metabolism*; D005658:Fungi / Q000378:metabolism*; D008386:Marine Biology / Q000379:methods; D008387:Marine Toxins; D008956:Models, Chemical; D010080:Oxazoles / Q000737:chemistry; D011161:Porifera / Q000382:microbiology*; D019311:Staurosporine / Q000494:pharmacology; D014561:Urochordata / Q000737:chemistry
D000470:Alkaloids; D001688:Biological Products; D005656:Fungal Proteins; D008387:Marine Toxins; D010080:Oxazoles; C059041:calyculin A; D019311:Staurosporine