title: Systemic lupus erythematosus.
abstract: Systemic lupus erythematosus in children and adolescents is a multisystem autoimmune disease with a great variability in disease presentation and course. This article summarizes available epidemiologic data, clinical patterns, approaches to investigation and treatment, and recent outcome data.
authors.affiliation: Division of Rheumatology, Department of Pediatrics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G IX8, Canada.
authors.forename: Susanne M
authors.initials: SM
authors.lastname: Benseler
authors.forename: Earl D
authors.initials: ED
authors.lastname: Silverman
mesh_terms: D000293:Adolescent; D001921:Brain / Q000503:physiopathology; D002648:Child; D003072:Cognition Disorders / Q000453:epidemiology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy*; D009069:Movement Disorders / Q000453:epidemiology; D010523:Peripheral Nervous System Diseases / Q000453:epidemiology; D011618:Psychotic Disorders / Q000453:epidemiology; D012640:Seizures / Q000453:epidemiology; D009626:Terminology as Topic