Activation of adenosine receptors in the posterior cingulate cortex impairs memory retrieval in the rat.
Adenosine A1 and A2A receptor agonists and antagonists have been reported to alter learning and memory. The aim of our study was to investigate the involvement of adenosinergic system in memory retrieval into posterior cingulate cortex (PCC) of Wistar rats. To clarify this question, we tested specifics agonist and antagonists of adenosine A1 and A2A receptors in rats submitted to a one-trial inhibitory avoidance task. The stimulation of adenosine A1 and A2A receptors by CPA and CGS21680, respectively, impaired memory retrieval for inhibitory avoidance task, into PCC. These findings provide behavioral evidence for the role of adenosinergic system in the memory retrieval into PCC.
Pereira
Grace Schenatto
GS
Instituto de Pesquisas Biomédicas, Pontifícia universidade Católica do Rio Grande do Sul, Porto Alegre, Rs, Brazil.graceschenatto@hotmail.com
Rossato
Janine Inez
JI
Sarkis
João José Freitas
JJ
Cammarota
Martín
M
Bonan
Carla Denise
CD
Izquierdo
Iván
I
D000241:Adenosine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D005106:Exploratory Behavior / Q000502:physiology; D006179:Gyrus Cinguli / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D008845:Microinjections; D010627:Phenethylamines / Q000008:administration & dosage; D058913:Purinergic Agonists; D058914:Purinergic Antagonists; D051381:Rats; D017208:Rats, Wistar; D043682:Receptor, Adenosine A1 / Q000187:drug effects / Q000378:metabolism*; D043705:Receptor, Adenosine A2A / Q000187:drug effects / Q000378:metabolism*; D014227:Triazines / Q000008:administration & dosage; D014230:Triazoles / Q000008:administration & dosage; D014970:Xanthines / Q000008:administration & dosage
D010627:Phenethylamines; D058913:Purinergic Agonists; D058914:Purinergic Antagonists; D043682:Receptor, Adenosine A1; D043705:Receptor, Adenosine A2A; D014227:Triazines; D014230:Triazoles; D014970:Xanthines; C097270:ZM 241385; C061282:2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine; C048599:N(6)-cyclopentyladenosine; C051360:1,3-dipropyl-8-cyclopentylxanthine; D000241:Adenosine