Cerebrospinal fluid insulin-like growth factor 1 is low in acute and chronic white-matter diseases of children.
Insulin-like growth factor 1 increases both the number of oligodendrocytes and the amount of axonal myelin produced. The aim of this study was to see whether insulin-like growth factor 1 played a role in white-matter diseases of children. We studied insulin-like growth factor 1 in the cerebrospinal fluid of children with various white-matter diseases: (1) children with acute demyelinating events: acute disseminated encephalomyelitis (n = 5), acute transverse myelitis in multiple sclerosis (n = 1), and infarct of the medial cerebral artery causing secondary white-matter changes (n = 1), and (2) children with chronic diseases: delayed myelination (n = 3) and progressive leukodystrophies (n = 4). Insulin-like growth factor 1 was determined by radioimmunoassay with commercially available kits (Mediagnost, Tubingen, Germany). We found markedly lower concentrations of cerebrospinal fluid insulin-like growth factor 1 in the patients than in the 28 age-matched control children (P < .0005). Low cerebrospinal fluid insulin-like growth factor 1 can play a role in the pathology of both acute and chronic white-matter diseases of children.
Riikonen
Raili
R
Department of Child Neurology, Children's Hospital, Kuopio University Hospital, Kuopio, Finland. raili.riikonen@uku.fi
Turpeinen
Ursula
U
D000208:Acute Disease; D000293:Adolescent; D001927:Brain Diseases / Q000134:cerebrospinal fluid*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004673:Encephalomyelitis, Acute Disseminated / Q000134:cerebrospinal fluid*; D005260:Female; D006429:Hemiplegia / Q000134:cerebrospinal fluid*; D020279:Hereditary Central Nervous System Demyelinating Diseases / Q000134:cerebrospinal fluid*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000134:cerebrospinal fluid*; D008297:Male; D009188:Myelitis, Transverse / Q000134:cerebrospinal fluid*
D007334:Insulin-Like Growth Factor I