Immunological similarities between implantation and pre-eclampsia.
OBJECTIVE
Cytokines are involved in implantation success and failure. We envisage that they could be similarly involved in pre-eclampsia (PE).


METHODS
First, we review the primipaternity and primiparity concepts and then why natural killer (NK) cells are involved in implantation. We stress that the common event in all PE is vascular remodelling.


CONCLUSIONS
We conclude that PE could involve cytokine and/or NK dysfunctions, and propose a working hypothesis.
Chaouat
Gérard
G
U 131 IN-SERM, Equipe cytokines et relation materno foetale, Hôpital Antoine Béclère, 92141 Clamart Cedex, France. gerard_chaouat@wanadoo.fr
Ledée-Bataille
Nathalie
N
Dubanchet
Sylvie
S
D016207:Cytokines / Q000276:immunology; D010064:Embryo Implantation / Q000276:immunology*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology*; D010920:Placenta / Q000098:blood supply / Q000276:immunology*; D011225:Pre-Eclampsia / Q000209:etiology / Q000276:immunology*; D011247:Pregnancy
D016207:Cytokines