title: An adaptive meta-clustering approach: combining the information from different clustering results.
abstract: With the development of microarray techniques, there is an increasing need of information processing methods to analyze the high throughput data. Clustering is one of the most promising candidates because of its simplicity, flexibility and robustness. However, there is no "perfect" clustering approach outperforming its counterparts, and it is hard to evaluate and combine the results from different techniques, especially in a field without much prior knowledge, such as bioinformatics. This paper proposes a meta-clustering approach to extract the information from results of different clustering techniques, so that a better interpretation of the data distribution can be obtained. A special distance measure is defined to represent the statistical "signal" of each cluster produced by various clustering techniques. The algorithm is applied on both artificial and real data Simulations show that the proposed approach is able to extract the information efficiently and accurately from the input clustering structure.
authors.affiliation: Electrical/Computer Engineering Department, University of Delaware, USA. zeng@ee.udel.edu
authors.forename: Yujing
authors.initials: Y
authors.lastname: Zeng
authors.forename: Jianshan
authors.initials: J
authors.lastname: Tang
authors.forename: Javier
authors.initials: J
authors.lastname: Garcia-Frias
authors.forename: Guang R
authors.initials: GR
authors.lastname: Gao
mesh_terms: D000465:Algorithms; D016000:Cluster Analysis; D020869:Gene Expression Profiling / Q000379:methods*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods*; D016415:Sequence Alignment / Q000379:methods; D017422:Sequence Analysis, DNA / Q000379:methods*