Characterization and management of paradoxical upgrading reactions in HIV-uninfected patients with lymph node tuberculosis.
In a retrospective analysis, paradoxical deterioration of lymph node tuberculosis in human immunodeficiency virus-uninfected patients was common, occurring in 25 (23%) of 109 patients after treatment had been given for a median of 46 days (interquartile range, 21-139 days) and persisting for a median of 67.5 days (interquartile range, 34-111 days). We found no association between the use of steroids and the duration of reaction.
Hawkey
Charlotte R
CR
Department of Infection and Tropical Medicine, North West London Hospitals National Health Service Trust, Northwick Park Hospital, Harrow, United Kingdom.
Yap
Timothy
T
Pereira
Janis
J
Moore
David A J
DA
Davidson
Robert N
RN
Pasvol
Geoffrey
G
Kon
Onn Min
OM
Wall
Robert A
RA
Wilkinson
Robert J
RJ
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014388:Tuberculosis, Lymph Node / Q000188:drug therapy*
D000305:Adrenal Cortex Hormones; D000995:Antitubercular Agents