Different firing patterns induced by veratridine and aconitine in injured dorsal root ganglion neurons.
Ectopic spontaneous activity originated from the injured dorsal root ganglion (DRG) neurons in rats was recorded through single dorsal root fiber. The firing patterns induced by veratridine and aconitine, inhibitors of inactivation gate of sodium channel operating on different binding sites, were compared. In the same neuron, veratridine (1.5 approximately 5.0 micromol/L) caused slow wave oscillations of interspike intervals (ISIs), while aconitine (10 approximately 200 micromol/L) caused tonic firing. Moreover, even if the background firing patterns were various and the reagent concentrations used were different, veratridine and aconitine still induced slow wave oscillations and tonic firing patterns, respectively. The results suggest that veratridine and aconitine induce different firing patterns in injured DRG neurons, which may relate to their inhibitory effects on different binding sites of the sodium channel.
Duan
Jian-Hong
JH
Institute of Neuroscience, The Fourth Military Medical University, Xi'an 710032, China.
Xing
Jun-Ling
JL
Yang
Jing
J
Hu
San-Jue
SJ
D000157:Aconitine / Q000494:pharmacology*; D000818:Animals; D055724:Electrophysiological Phenomena / Q000502:physiology; D005260:Female; D005727:Ganglia, Spinal / Q000293:injuries / Q000503:physiopathology*; D008297:Male; D009474:Neurons / Q000473:pathology / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D062687:Sodium Channel Agonists; D015222:Sodium Channels / Q000502:physiology*; D014701:Veratridine / Q000494:pharmacology*
D062687:Sodium Channel Agonists; D015222:Sodium Channels; D014701:Veratridine; D000157:Aconitine