title: Langerhans-cell histiocytosis: a clinical case without bone involvement.
abstract: BACKGROUND
  Langerhans-cell histiocytosis (LCH) is a group of rare disorders histologically characterized by the proliferation of Langerhans cells. Multiple organs and systems may be involved by the disease. Typically, there is bone involvement and, less frequently, lesions may be found in the lungs, liver, lymph nodes, skin, and mucosae. Oral soft tissue lesions without bone involvement are rare.
  
  
  METHODS
  We report a case of a 23-year-old man with LCH detected by oral soft tissue, cutaneous, and lung lesions.
  
  
  RESULTS
  Due to the oral lesion diagnosis, important procedures were performed, which determined the staging of the disease.
  
  
  CONCLUSIONS
  Gingival lesions could be one of the first manifestations of LCH. The periodontist should recognize and detect this important pathology with oral involvement.
authors.affiliation: Department of Otorhino-Laryngology and Ophthalmology, Dental and Maxillo-Facial Sciences, Dentistry and Oral Medicine Section, University of Parma, Parma, Italy. maddalena.manfredi@unipr.it
authors.forename: M
authors.initials: M
authors.lastname: Manfredi
authors.forename: D
authors.initials: D
authors.lastname: Corradi
authors.forename: P
authors.initials: P
authors.lastname: Vescovi
mesh_terms: D000328:Adult; D018949:Antigens, CD1 / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D001847:Bone Diseases / Q000175:diagnosis / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D019226:Oral Ulcer / Q000473:pathology*; D009418:S100 Proteins / Q000032:analysis
chemical_list: D018949:Antigens, CD1; D015415:Biomarkers; C419393:CD1a antigen; D009418:S100 Proteins