Spectrally programmable light engine for in vitro or in vivo molecular imaging and spectroscopy.
A spectrally and temporally programmable light engine can create any spectral profile for hyperspectral, fluorescence, or principal-component imaging or with medical photonics devices employing spectroscopy, microscopy, and endoscopy. Multispectral imaging feasibility was demonstrated by capturing nine images at wavelengths from 450 to 650 mm (25-nm FWHM) with a CCD-camera-equipped bronchoscope coupled to the light engine. Selected wavelength regions were combined to produce a color endoscopy image.
MacKinnon
Nicholas
N
Cancer Imaging Department, British Columbia Cancer Research Centre, Vancouver V5Z1L3, British Columbia, Canada. nmackinn@bccrc.ca
Stange
Ulrich
U
Lane
Pierre
P
MacAulay
Calum
C
Quatrevalet
Mathieu
M
D020680:Bronchoscopes; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005240:Feasibility Studies; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D008967:Molecular Biology / Q000295:instrumentation* / Q000379:methods; D055095:Optics and Photonics / Q000295:instrumentation*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013053:Spectrophotometry / Q000295:instrumentation* / Q000379:methods