Vascular implications of the Krüppel-like family of transcription factors.
The Krüppel-like factor (KLF) family is a recently highlighted group of zinc finger transcription factors given their important biological roles which include the vasculature. KLF2, KLF4, KLF5, and KLF6 are notable factors that have been implicated in developmental as well as pathological vascular processes. In this brief review, we provide an up-to-date summary of the physiological functions and cellular effects as well as transcriptional regulatory mechanisms of the vascular KLFs. Through such, we aim to provide a working view for understanding the pathological actions of KLFs in the vasculature.
Suzuki
Toru
T
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Japan. torusuzu-tky@umin.ac.jp
Aizawa
Kenichi
K
Matsumura
Takayoshi
T
Nagai
Ryozo
R
D000818:Animals; D001808:Blood Vessels / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors / Q000502:physiology*; D014652:Vascular Diseases / Q000235:genetics / Q000503:physiopathology*
C000715467:KLF4 protein, human; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors