title: Recurrent Candida tropicalis meningitis.
abstract: Candida meningitis, a previously rare occurrence, has been increasing in prevalence and often is a result of complications of neurosurgery. We describe the case of a 49-year-old man who presented with headache, vertigo, intermittent blurred vision, and multiple episodes of nausea and vomiting. Computed tomography (CT) showed a left cerebellar hemorrhage with obliteration of the fourth ventricle causing hydrocephalus. He had an occipital craniotomy with transcondylar evacuation of the hemorrhage and placement of a temporary ventriculostomy. The hospital stay was prolonged because of postsurgical complications, and Candida tropicalis meningitis developed. Treatment was started with 400 mg of fluconazole administered intravenously every 12 h. In vitro susceptibility testing showed a minimum inhibitory concentration (MIC) to fluconazole of 1 microg/mL. Fluconazole was therefore continued orally for a total of 60 days, and the patient remained asymptomatic for 2 years. He then presented with increased vertigo and ataxia. Cerebrospinal fluid cultures grew C. tropicalis, which again showed susceptibility to fluconazole with a MIC of 1 microg/mL, identical to that in the previous infection. However, a second course of fluconazole failed to control the infection despite adequate cerebrospinal fluid levels.
authors.affiliation: Division of Community Internal Medicine, Mayo Clinic, Jacksonville, FL 32224, USA.
authors.forename: Nancy L
authors.initials: NL
authors.lastname: Dawson
authors.forename: Hector A
authors.initials: HA
authors.lastname: Robles
authors.forename: Salvador
authors.initials: S
authors.lastname: Alvarez
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D041022:Candida tropicalis; D002177:Candidiasis / Q000188:drug therapy / Q000209:etiology*; D003399:Craniotomy / Q000009:adverse effects*; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D008297:Male; D016921:Meningitis, Fungal / Q000188:drug therapy / Q000209:etiology*; D008875:Middle Aged; D012008:Recurrence; D017211:Treatment Failure; D014696:Ventriculostomy / Q000009:adverse effects*
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole