Novel approach to nucleoside-5'-(1-hydroxymethylene-1, 1-bisphosphonates): synthesis of new AZT analogues.
An efficient synthetic method of nucleoside-5'-(1-hydroxymethylene-1,1-bisphosphonates) is reported here. The procedure was optimized with 3'-protected thymidine and then applied to synthesis of new AZT analogues.
Migianu
Evelyne
E
Laboratoire de Chimie Structurale Biomoléculaire (UMR 7033-CNRS), UFR SMBH, Université Paris 13, Bobigny Cedex, France.
Monteil
Maëlle
M
Even
Pascale
P
Lecouvey
Marc
M
D000998:Antiviral Agents / Q000138:chemical synthesis; D015394:Molecular Structure; D015215:Zidovudine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry
D000998:Antiviral Agents; D015215:Zidovudine