title: Pathological prion protein in the tongues of sheep infected with naturally occurring scrapie.
abstract: Tongue involvement by prion spreading was shown to be a common outcome after oral or intracranial experimental challenge with scrapie and transmissible mink encephalopathy sources in rodent models. It is also known that bovine spongiform encephalopathy, which is pathogenic for humans, is experimentally transmissible to sheep and can lead to a disease indistinguishable from scrapie. A recent European Food Safety Authority opinion recommended research into PrPsc accumulation in the tongues of ruminants. We report on the detection of PrPsc in the tongues of seven scrapie-infected sheep by immunohistochemistry and Western blotting.
authors.affiliation: CEA-IZS Piemonte, Liguria e Valle d'Aosta, Via Bologna, 148 Turin 10154, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Casalone
authors.forename: Cristiano
authors.initials: C
authors.lastname: Corona
authors.forename: Maria Ines
authors.initials: MI
authors.lastname: Crescio
authors.forename: Francesca
authors.initials: F
authors.lastname: Martucci
authors.forename: Maria
authors.initials: M
authors.lastname: Mazza
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ru
authors.forename: Elena
authors.initials: E
authors.lastname: Bozzetta
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Acutis
authors.forename: Maria
authors.initials: M
authors.lastname: Caramelli
mesh_terms: D000818:Animals; D015153:Blotting, Western; D007150:Immunohistochemistry; D018620:PrPSc Proteins / Q000302:isolation & purification / Q000378:metabolism*; D012608:Scrapie / Q000378:metabolism*; D012756:Sheep / Q000378:metabolism*; D014059:Tongue / Q000033:anatomy & histology / Q000378:metabolism*
chemical_list: D018620:PrPSc Proteins