Genetic susceptibility to tuberculosis.
Host genetic factors are important in determining susceptibility and resistance to Mycobacterium tuberculosis. The etiology of tuberculosis is complex, and several host genes have been shown to contribute to the development of clinical disease. The success of the strategies used to investigate host genetic susceptibility to mycobacterial infections can serve as a model for the investigation of host susceptibility to other infectious diseases.
Bellamy
Richard
R
James Cook University Hospital, Marton Road, Middlesbrough TS4 3BW, UK. bellamyrj2000@yahoo.co.uk
D000818:Animals; D008040:Genetic Linkage / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D014376:Tuberculosis / Q000235:genetics* / Q000635:transmission