Fusarium verticillioides abscess of the nasal septum in an immunosuppressed child: case report and identification of the morphologically atypical fungal strain.
Morphologically atypical Fusarium verticillioides causing a nasal abscess in a severely immunosuppressed child was successfully treated with repeated surgical intervention and liposomal amphotericin B, despite amphotericin B resistance in vitro. Definitive identification was achieved by sequencing the translation elongation factor alpha gene after ribosomal sequencing proved inadequate.
Dornbusch
Hans Jürgen
HJ
Division of Pediatric Hematology/Oncology, Medical University, Graz, the Netherlands.
Buzina
Walter
W
Summerbell
Richard C
RC
Lass-Flörl
Cornelia
C
Lackner
Herwig
H
Schwinger
Wolfgang
W
Sovinz
Petra
P
Urban
Christian
C
D000038:Abscess / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use; D002648:Child; D005670:Fusarium / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D016867:Immunocompromised Host; D008081:Liposomes / Q000627:therapeutic use; D008297:Male; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009181:Mycoses / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D009300:Nasal Septum / Q000382:microbiology*; D017422:Sequence Analysis, DNA
D000935:Antifungal Agents; D008081:Liposomes; C068538:liposomal amphotericin B; D000666:Amphotericin B