title: The specificity and sensitivity of uninhibited COR in labyrinthine-defective patients.
abstract: The Cervico-ocular reflex (COR), which depends on proprioceptive afferents from neck muscles to the vestibular nucleus, makes little contribution to the stabilization of gaze in humans. If labyrinthine function is lost because of disease, however, the COR may increase in gain and assume greater importance in generating compensatory eye rotations during natural head movements. We tested the COR, i.e., eye movement responses to rotation of the trunk about the earth fixed head (swinging test with fixed head STFH). If the vestibular function is intact, normally there should be no nystagmus. A total of 88 labyrinthine defective patients and 78 controls were studied. Of the 166 subjects evaluated, 88 presented some kind of alteration (either central or peripheral) and had STFH results showing "no inhibition" in 85 patients. Therefore, the STFH's sensibility is 96.6%. The remaining 3.4% were false negatives (i.e., pathology that could not be detected by the test). Of the 166 subjects evaluated, 78 had normal results and normal STFH. Therefore, STFH's specificity was 100%. We conclude that the study of the COR through STFH is a simple, useful, and clinically reliable test which should improve our knowledge of the interesting relationship between VOR and COR.
authors.affiliation: Instituto San Lucas, Neurosciences, Roasario, Argentina. scarmona@arnet.com.ar
authors.forename: Sergio
authors.initials: S
authors.lastname: Carmona
authors.forename: Daniela
authors.initials: D
authors.lastname: Nieto
mesh_terms: D005133:Eye Movements / Q000502:physiology*; D005403:Fixation, Ocular; D019416:Head Movements / Q000502:physiology; D006801:Humans; D007759:Labyrinth Diseases / Q000175:diagnosis* / Q000503:physiopathology; D012016:Reference Values; D012018:Reflex; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity