title: [Significance of extracellular matrix determined by immunostains and histochemical stains in a case of pulmonary epithelioid hemangioendothelioma].
abstract: We have analyzed extracellular matrix(ECM) of a case of pulmonary epithelioid hemangioendothelioma (PEH). Type IV collagen and laminin were existed in the ECM and were condensed around the tumor cell nests in meshwork pattern. Elastica-van Gieson stain revealed elastic fibers in this meshwork. These findings suggested that enhanced basement membrane protein synthesis in PEH seems to be responsible for the accumulation of abundant ECM. Analysis of the ECM seems to be quite useful for the differential diagnosis of this tumor.
authors.affiliation: Aichi Health Promotion Foundation, Nagoya 462-0844.
authors.forename: Hideo
authors.initials: H
authors.lastname: Saito
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Ishida
authors.forename: Aki
authors.initials: A
authors.lastname: Kakutani
authors.forename: Ryoji
authors.initials: R
authors.lastname: Kushima
authors.forename: Kazuo
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Tokuhiro
authors.initials: T
authors.lastname: Chano
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Okabe
mesh_terms: D000328:Adult; D003094:Collagen / Q000032:analysis; D004396:Coloring Agents; D005109:Extracellular Matrix / Q000378:metabolism*; D016326:Extracellular Matrix Proteins / Q000032:analysis; D005260:Female; D018323:Hemangioendothelioma, Epithelioid / Q000473:pathology*; D006801:Humans; D007158:Immunologic Techniques; D008175:Lung Neoplasms / Q000473:pathology*
chemical_list: D004396:Coloring Agents; D016326:Extracellular Matrix Proteins; D003094:Collagen