Social adjustment could be associated with the serotonin transporter gene in remitted patients with mood disorders and healthy subjects.
We investigated the serotonin transporter gene (5-HTTLPR) in the functioning of euthymic patients with mood disorders (n=285) and healthy controls (n=94). The 5-HTTLPR genotype showed marginal associations with working, familial and social adjustment, with marked differences between controls and patients. Because of the exploratory nature of our analyses, all results should be viewed with caution. However, we observed how the s/s variant, commonly associated with detrimental effects, could be beneficial in specific areas of social adjustment.
Serretti
Alessandro
A
Department of Psychiatry, Istituto Scientifico H San Raffaele, Vita-Salute University, San Raffaele Institute, Via Stamira D'Ancona 20, 20127 Milan, Italy. serretti.alessandro@hsr.it
Mandelli
Laura
L
Lorenzi
Cristina
C
Smeraldi
Enrico
E
D000328:Adult; D000483:Alleles; D005075:Biological Evolution; D003865:Major Depressive Disorder / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins / Q000235:genetics*; D019964:Mood Disorders / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D012074:Remission Induction; D012189:Retrospective Studies; D012641:Selection, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins; D012917:Social Adjustment; D012919:Social Behavior; D011795:Surveys and Questionnaires
D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins