title: Ethical consideration of intentioned preimplantation genetic diagnosis to enable future tissue transplantation.
abstract: Recently, a case was presented where a couple with one normal child requested preimplantation genetic diagnosis (PGD) with human leukocyte antigen (HLA) typing in order to conceive children who could serve as mutual donors for future transplantations if needed. While PGD for medical reasons is well defined and accepted, application for non-medical conditions is less obvious and still in debate. The present case calls to further extend the indications for PGD and raises a moral question as to whether to allow such intentioned treatment. Although it seems that all siblings might benefit from the procedure, when weighing the risks benefits and the ethical issues included in performing intentioned PGD, it seems that the procedure harbours risks and ethical issues that outweigh the benefit it offers. Therefore, it is time to constrain the slippery slope and state that intentioned PGD for conceiving children who might serve as siblings for mutual tissue donations should be declined.
authors.affiliation: Department of Obstetrics and Gynecology, Hadassah University Hospital, Ein Kerem, PO Box 12000, Jerusalem 91120, Israel. asimon@md.huji.ac.il
authors.forename: Alex
authors.initials: A
authors.lastname: Simon
authors.forename: Joseph G
authors.initials: JG
authors.lastname: Schenker
mesh_terms: D033001:Directed Tissue Donation / Q000941:ethics*; D004622:Embryo, Mammalian; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D009014:Morals; D011247:Pregnancy; D019836:Preimplantation Diagnosis / Q000941:ethics*; D012307:Risk Factors; D014019:Tissue Donors / Q000941:ethics*