title: [Cartilage cell transplantation as an alternative to endoprosthesis].
abstract: The incidence of cartilage lesions is high. Due to pain and loss of function, long-term therapy is often necessary. Isolated, full-thickness articular cartilage lesions with a diameter of 4 cm2 are indications for chondrocyte transplantation. Many outcome studies report good long-term results. In recent years, the cultivation of chondrocytes has changed. Histologic investigations show hyalin-like cartilage after transplantation. Large cartilage lesions facing each other are a therapeutic dilemma in young patients. Implanting unicondylar or bicondylar prostheses is sometimes the last resort for these patients, and there are several reports of good clinical outcome. Cartilage transplantation has until now been recommended for patients younger than 50. It is not an alternative to joint replacement.
authors.affiliation: Unfallchirurgische Klinik, Medizinische Hochschule Hannover.
authors.forename: C
authors.initials: C
authors.lastname: Krettek
authors.forename: M
authors.initials: M
authors.lastname: Jagodzinski
authors.forename: J
authors.initials: J
authors.lastname: Zeichen
mesh_terms: D000328:Adult; D001171:Arthritis, Juvenile / Q000601:surgery; D019643:Arthroplasty, Replacement; D019645:Arthroplasty, Replacement, Knee; D002358:Cartilage, Articular / Q000166:cytology* / Q000293:injuries; D019902:Chondrocytes / Q000637:transplantation*; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D010003:Osteoarthritis / Q000601:surgery; D010008:Osteochondritis Dissecans / Q000601:surgery; D016032:Randomized Controlled Trials as Topic; D023822:Tissue Engineering