title: Gentamicin induced ototoxicity during treatment of enterococcal endocarditis: resolution with substitution by netilmicin.
abstract: Enterococcal endocarditis can be very difficult to eradicate, requiring prolonged treatment with a combination of a penicillin and an aminoglycoside. In this patient with a pacemaker associated enterococcal endocarditis, ototoxicity occurred due to total gentamicin dose despite plasma concentrations consistently within the treatment range. Substitution with netilmicin, without a break in aminoglycoside treatment, resulted in a rapid improvement in hearing and allowed the required course of aminoglycoside to be completed. The risk factors for ototoxicity with gentamicin are reviewed, in particular the dangers of increasing age and of multiple and prolonged courses. Close treatment monitoring does not totally avoid this risk, especially when prolonged aminoglycoside treatment is required. This case emphasises the need for prompt investigation and adequate, definitive treatment of enterococcal endocarditis to avoid the increased risk consequent on repeated courses of antibiotics. The resolution of the ototoxicity with netilmicin is consistent with other reports of lower cochleotoxicity than with other aminoglycosides.
authors.affiliation: Papworth Hospital, Papworth Everard, Cambridge, UK.
authors.forename: J E
authors.initials: JE
authors.lastname: East
authors.forename: J E
authors.initials: JE
authors.lastname: Foweraker
authors.forename: F D
authors.initials: FD
authors.lastname: Murgatroyd
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004697:Endocarditis, Bacterial / Q000188:drug therapy*; D004866:Equipment Contamination; D005839:Gentamicins / Q000009:adverse effects*; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced*; D006801:Humans; D008297:Male; D009428:Netilmicin / Q000627:therapeutic use*; D010138:Pacemaker, Artificial
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D009428:Netilmicin