[Study on the changes in serum leukotrienes B4 and p38 mitogen activated protein kinase in multiple organ dysfunction syndrome].
OBJECTIVE
To investigate the changes in serum leukotrienes B4(LTB4) and p38 mitogen activated protein kinase (p38 MAPK) in multiple organ dysfunction syndrome (MODS) and to evaluate the relationship between LTB4 and p38 MAPK and clinical condition of patients with MODS.


METHODS
The clinical condition of 26 patients with MODS was evaluated with scoring system. The serum LTB4 and p38 MAPK of the said patients and that of 12 healthy individuals were determined with enzyme linked immunoadsorbent assay(ELISA). The correlation of the scores of MODS and levels of serum LTB4 and p38 MAPK was analyzed. The correlation of the scores of MODS and levels of serum LTB4 and p38 MAPK was analyzed in non-survivors and survivors.


RESULTS
The serum level of LTB4[(923.96+/-308.65)ng/L] was significantly lower in MODS patients compared with control group [(2 453.31+/-400.93)ng/L, P<0.05]. There was no significant difference in serum level of p38 MAPK between the patients with MODS [(193.83+/-106.32)ng/L]ls and control group [(124.36+/- 84.50)ng/L, P>0.05]. There was significant difference in the serum level of LTB4 between the survivors[(1 334.51+/-530.35)ng/L] and non-survivors [(444.98+/-206.30)ng/L, P<0.05]. There were significant negative correlations between serum LTB4 and MODS scores (P<0.001).


CONCLUSIONS
The pathophysiological changes in later period of MODS are different from those of other common inflammatory responses. Serum LTB4 and p38 MAPK could be one of the indexes of the severity and prognosis on MODS.
Tang
Hao
H
Emergency Department, the First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080, Guangdong China.
Ma
Zhong-fu
ZF
Liang
Yan-bing
YB
Zhai
Cheng-shun
CS
Xiong
Shi-qiu
SQ
Xiong
Yan
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007975:Leukotriene B4 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood*; D055815:Young Adult; D048051:p38 Mitogen-Activated Protein Kinases / Q000097:blood*
D007975:Leukotriene B4; D048051:p38 Mitogen-Activated Protein Kinases