title: Effect of nutritional state on postoperative axillary leakage after axillary lymph node dissection in a new rat model.
abstract: OBJECTIVE
  Axillary leakage after axillary lymph node dissection (ALD) in breast cancer surgery is a frequent and troublesome complication. We conducted this study to establish an experimental model of axillary leakage after ALD; to evaluate axillary leakage in different nutritional states; and to examine the effects of dietary management on axillary leakage.
  
  
  METHODS
  Twenty-eight Wistar rats were divided into two groups according to whether they were fed a high-fat diet or a low-fat diet for 14 weeks before ALD. After ALD, a suction drain was placed in the axilla and continuous suction was started. Axillary leakage was monitored for 9 days, and the drainage fluid and serum were analyzed biochemically.
  
  
  RESULTS
  The body weights of the two groups were not significantly different before or after ALD. The amount of cumulative drainage fluid was significantly higher on postoperative days 7 and 9 in the high-fat group. The serum phosphate lipid, total cholesterol, and free cholesterol levels, and the free cholesterol level in the drainage fluid were also significantly higher in the high-fat group.
  
  
  CONCLUSIONS
  This model is useful for reproducing lymphatic leakage after ALD. Our findings also suggest that a low-fat diet may be advantageous for patients undergoing ALD as part of breast cancer surgery.
authors.affiliation: Department of Surgical Oncology, Breast and Endocrine Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kijima
authors.forename: Heiji
authors.initials: H
authors.lastname: Yoshinaka
authors.forename: Tetsuhiro
authors.initials: T
authors.lastname: Owaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Aikou
mesh_terms: D000818:Animals; D001365:Axilla; D004195:Disease Models, Animal; D004322:Drainage / Q000379:methods; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000601:surgery*; D008210:Lymphocele / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D009752:Nutritional Status; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar