title: Case report: acute pancreatitis induced by Clozapine.
abstract: Two percent of acute pancreatitis are drug induced. In the present paper, we reported the case of a 39 year-old patient with chronic-hallucinatory schizophrenia who developed symptomatic pancreatitis during the clozapine dose titration performed to reach the therapeutic range. Diagnosis of pancreatitis was suggested by clinical examination and abnormal laboratory values of pancreatic enzymes and confirmed by C-T scan and ultrasonography. The causal incrimination of clozapine in this case seems likely as all other possible causes of pancreatitis were excluded, as AP developed shortly after the introduction of the drug and as the pancreatic enzymes normalized after clozapine was stopped. No rechallenge to confirm the causal relationship was however attempted. So far, only eight cases of acute pancreatitis have been reported in association with clozapine use. Clozapine is an atypical antipsychotic drug which belongs to the chemical class of dibenzodiazepines. The mechanism by which clozapine could produce acute pancreatitis remained unclear. Nevertheless, we advocate a careful biological follow-up (measuring periodically the concentrations of amylase, lipase and triglycerides) during the treatment by clozapine.
authors.affiliation: Service de Psychiatrie, Centre hospitalier Jolimont-Lobbes, Haine Saint-Paul, Belgium.
authors.forename: J-M F
authors.initials: JM
authors.lastname: Bayard
authors.forename: O S
authors.initials: OS
authors.lastname: Descamps
authors.forename: S
authors.initials: S
authors.lastname: Evrard
authors.forename: J M
authors.initials: JM
authors.lastname: Dumonceau
authors.forename: L
authors.initials: L
authors.lastname: Servais
authors.forename: Z
authors.initials: Z
authors.lastname: Zingir
authors.forename: S
authors.initials: S
authors.lastname: Adams
authors.forename: V
authors.initials: V
authors.lastname: Dassy
authors.forename: E
authors.initials: E
authors.lastname: Stillemans
authors.forename: A
authors.initials: A
authors.lastname: Seutin
authors.forename: P
authors.initials: P
authors.lastname: Titeca
authors.forename: J
authors.initials: J
authors.lastname: Titeca
mesh_terms: D000208:Acute Disease; D000328:Adult; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006801:Humans; D008134:Long-Term Care; D008297:Male; D010186:Pancreatic Function Tests; D010195:Pancreatitis / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D018570:Risk Assessment; D012563:Schizophrenia, Paranoid / Q000175:diagnosis / Q000188:drug therapy*; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed
chemical_list: D003024:Clozapine