Host factors regulating post-integration latency of HIV.
A recent study has provided important clues towards the identity of the host genes that conspire to promote post-integration latency of human immunodeficiency virus (HIV). Various genes controlling transcription, histone deacetylation and proteasome-mediated protein degradation have emerged as potential players. If the desired, but difficult, goal of complete virus eradication in HIV-infected patients is ever to be realized, the latent reservoir of HIV proviruses must be cleared. Understanding the molecular basis for viral latency is the key first step.
Williams
Samuel A F
SA
Gladstone Institute of Virology and Immunology, 1650 Owens Street, San Francisco, CA 94158, USA.
Greene
Warner C
WC
D015496:CD4-Positive T-Lymphocytes / Q000502:physiology / Q000821:virology*; D015967:Gene Expression Regulation, Viral; D006678:HIV / Q000235:genetics / Q000502:physiology*; D006801:Humans; D011533:Proviruses / Q000235:genetics / Q000502:physiology*; D016662:Virus Integration / Q000235:genetics; D017735:Virus Latency / Q000235:genetics