[Anti-inflammatory action of PPARs].
The PPARs transduce a wide variety of signals, including environmental and nutritional events, into a defined and ordered set of cellular responses at the transcriptional level. It has now been shown that all three PPAR isoforms (alpha, beta/delta and gamma) can participate in the regulation of inflammation responses. The ability of the PPARs to regulate inflammatory responses is a result of their transactivation and transrepression capacities. Most of the anti-inflammatory properties of the PPARs arise through their ability to antagonize nuclear factor-kappaB (NF-kappaB) and AP1 signaling pathways. By inhibiting these inflammatory transcription factors, the PPARs repress the expression of several genes that are involved in the inflammatory responses. In this review, I focus on emerging knowledge about PPARs roles in inflammatory responses.
Fujii
Hiroshi
H
Division of Molecular and Cellular Biology, Department of Signal Transduction Research, Niigata University, Graduate School of Medical and Dental Sciences.
D007249:Inflammation / Q000503:physiopathology*; D047494:PPAR delta / Q000502:physiology; D047492:Peroxisome Proliferator-Activated Receptors / Q000502:physiology*; D014158:Transcription, Genetic / Q000502:physiology
D047494:PPAR delta; D047492:Peroxisome Proliferator-Activated Receptors