title: DC-SIGN-mediated transfer of HIV-1 is compromised by the ability of Leishmania infantum to exploit DC-SIGN as a ligand.
abstract: DC-SIGN (dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin) binds human immunodeficiency virus type 1 (HIV-1) and facilitates transfer of virus to permissive cells. Leishmania parasites also exploit DC-SIGN as a receptor. Here, we report that transfer of HIV-1 to target cells is markedly reduced when DC-SIGN(+) cells are preincubated with Leishmania amastigotes before pulsing with virions. Moreover, binding of HIV-1 to DC-SIGN(+) cells is diminished by the presence of Leishmania amastigotes. Our findings provide novel insight into the complex interactions between HIV-1 and Leishmania parasites. The ability of both HIV-1 and Leishmania parasites to bind to the same cell-surface constituent to gain entry into dendritic cells might have an impact on the immunological and pathological events associated with HIV-1 infection.
authors.affiliation: Research Center in Infectious Diseases, CHUL Research Center, Laval University, Quebec, Canada.
authors.forename: Chenqi
authors.initials: C
authors.lastname: Zhao
authors.forename: Réjean
authors.initials: R
authors.lastname: Cantin
authors.forename: Marie
authors.initials: M
authors.lastname: Breton
authors.forename: Barbara
authors.initials: B
authors.lastname: Papadopoulou
authors.forename: Michel J
authors.initials: MJ
authors.lastname: Tremblay
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology*; D002460:Cell Line; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000469:parasitology* / Q000821:virology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D037181:Lectins, C-Type / Q000502:physiology*; D018314:Leishmania infantum / Q000502:physiology*; D011485:Protein Binding; D011956:Receptors, Cell Surface / Q000502:physiology*; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
chemical_list: D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin