title: Vesiculobullous eruption from intense pulsed light treatment.
abstract: BACKGROUND
  Intense pulsed light (IPL) systems emit non-coherent, polychromatic light and are increasingly used for various dermatologic indications. Although generally regarded as safe therapy, IPL is not without risk.
  
  
  OBJECTIVE
  We report a 21-year-old woman who experienced a severe blistering eruption after IPL treatment by a nonphysician.
  
  
  METHODS
  Case report.
  
  
  RESULTS
  The patient reported a 10-year history of persistent redness on her medial and lateral cheeks. She had tried no previous oral or topical therapies. She was diagnosed with rosacea and was treated with IPL. The following day, intense vesiculation and bullae formation occurred, progressing to dramatic facial edema by day 3 and eschar formation by day 5. Ten weeks later, prominent erythema with papularity remained on both cheeks and the lateral neck, with textural change and reticulated dyschromia. She continued to recover 20 weeks after treatment.
  
  
  CONCLUSIONS
  This case most likely represents high-fluence photothermal tissue injury induced by the laser-like qualities of the IPL source, with resulting acantholysis leading to formation of vesicobullae in the context of an uncertain primary diagnosis. This case highlights the potential hazards of IPL therapy and raises questions regarding appropriate use of this medical technology.
authors.affiliation: Department of Dermatology, University of Iowa, Iowa City, Iowa 52242, USA.
authors.forename: Brian R
authors.initials: BR
authors.lastname: Sperber
authors.forename: Hobart W
authors.initials: HW
authors.lastname: Walling
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Arpey
authors.forename: Duane C
authors.initials: DC
authors.lastname: Whitaker
mesh_terms: D000488:Allied Health Personnel; D018450:Disease Progression; D005260:Female; D006801:Humans; D008875:Middle Aged; D010789:Phototherapy / Q000009:adverse effects*; D012393:Rosacea / Q000601:surgery*; D012872:Skin Diseases, Vesiculobullous / Q000209:etiology*