title: Metabolic lung disease: imaging and histopathologic findings.
abstract: Metabolic lung disease includes pulmonary alveolar proteinosis (PAP), pulmonary amyloidosis, metastatic pulmonary calcification, dendritic pulmonary ossification, pulmonary alveolar microlithiasis, and storage diseases. In pulmonary alveolar proteinosis, CT demonstrates air-space consolidation with thickened interlobular septa, producing the so-called "crazy paving" appearance. Pulmonary amyloidosis can appear as parenchymal nodules (nodular parenchymal form), diffuse interstitial deposit (diffuse interstitial form), or submucosal deposits in the airways (tracheobronchial form). Metastatic pulmonary calcification may appear on high-resolution CT as numerous 3- to 10-mm diameter calcified nodules or, more commonly as fluffy and poorly defined nodular opacities. In pulmonary microlithiasis, high-resolution CT demonstrates diffuse punctuate micronodules showing slight perilobular predominance resulting in apparent calcification of interlobular septa. Niemann-Pick disease appears as ground-glass attenuation in the upper lung zone and thickening of the interlobular septa in the lower lung zone. Radiologic study including high-resolution CT will be helpful for the diagnosis and follow-up of these diseases.
authors.affiliation: Department of Radiology and Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Kangnam-Ku, Seoul 135-710, South Korea.
authors.forename: Myung Jin
authors.initials: MJ
authors.lastname: Chung
authors.forename: Kyung Soo
authors.initials: KS
authors.lastname: Lee
authors.forename: Tomás
authors.initials: T
authors.lastname: Franquet
authors.forename: Nestor L
authors.initials: NL
authors.lastname: Müller
authors.forename: Joungho
authors.initials: J
authors.lastname: Han
authors.forename: O Jung
authors.initials: OJ
authors.lastname: Kwon
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D008171:Lung Diseases / Q000175:diagnosis* / Q000473:pathology*; D008297:Male; D008488:Medical Illustration; D008875:Middle Aged; D013902:Radiography, Thoracic / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*