title: Determination of water compartments in rat myocardium using combined D-T1 and T1-T2 experiments.
abstract: We have used combined D-T1 and T1-T2 correlation experiments to explore water compartments in rat heart tissue (myocardium). The results show that two main compartments can be identified, which we assign to extracellular (ec) and intracellular (ic) water. The exchange rate of water across the cell membrane was found to be on the order of 0.1 Hz. In addition, the T1-T2 correlation measurements indicate that the ic compartment contain two T2 populations.
authors.affiliation: Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, N-7489 Trondheim, Norway. john.seland@medisin.ntnu.no
authors.forename: John Georg
authors.initials: JG
authors.lastname: Seland
authors.forename: Morten
authors.initials: M
authors.lastname: Bruvold
authors.forename: Henrik
authors.initials: H
authors.lastname: Anthonsen
authors.forename: Heidi
authors.initials: H
authors.lastname: Brurok
authors.forename: Wibeke
authors.initials: W
authors.lastname: Nordhøy
authors.forename: Per
authors.initials: P
authors.lastname: Jynge
authors.forename: Jostein
authors.initials: J
authors.lastname: Krane
mesh_terms: D000818:Animals; D001825:Body Fluid Compartments; D001834:Body Water / Q000737:chemistry*; D002463:Cell Membrane Permeability; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009206:Myocardium / Q000737:chemistry*; D016062:Porosity; D051381:Rats