title: Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors.
abstract: Organ-specific differences in epidermal growth factor receptor (EGFR) mutational spectra and frequencies were found in lung cancer and sporadic and BRCA1/2-related breast cancers. Additionally, we found a high frequency of EGFR mutations in the tumour stroma of these invasive breast carcinomas. Those organ-specific mutational spectra and potential targets in the cancer-associated stroma might influence the efficacy of TKI therapy.
authors.affiliation: Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: F
authors.initials: F
authors.lastname: Weber
authors.forename: K
authors.initials: K
authors.lastname: Fukino
authors.forename: T
authors.initials: T
authors.lastname: Sawada
authors.forename: N
authors.initials: N
authors.lastname: Williams
authors.forename: K
authors.initials: K
authors.lastname: Sweet
authors.forename: R M
authors.initials: RM
authors.lastname: Brena
authors.forename: C
authors.initials: C
authors.lastname: Plass
authors.forename: T
authors.initials: T
authors.lastname: Caldes
authors.forename: G L
authors.initials: GL
authors.lastname: Mutter
authors.forename: M A
authors.initials: MA
authors.lastname: Villalona-Calero
authors.forename: C
authors.initials: C
authors.lastname: Eng
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002277:Carcinoma / Q000235:genetics* / Q000473:pathology; D004252:DNA Mutational Analysis; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D066246:ErbB Receptors / Q000235:genetics*; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D017154:Stromal Cells
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D066246:ErbB Receptors; D011505:Protein-Tyrosine Kinases