title: Effects of intravenous hyperosmotic sodium bicarbonate on arterial and cerebrospinal fluid acid-base status and cardiovascular function in calves with experimentally induced respiratory and strong ion acidosis.
abstract: The objectives of this study were to determine the effects of hyperosmotic sodium bicarbonate (HSB) administration on arterial and cerebrospinal fluid (CSF) acid-base balance and cardiovascular function in calves with experimentally induced respiratory and strong ion (metabolic) acidosis. Ten healthy male Holstein calves (30-47 kg body weight) were instrumented under halothane anesthesia to permit cardiovascular monitoring and collection of blood samples and CSE Respiratory acidosis was induced by allowing the calves to spontaneously ventilate, and strong ion acidosis was subsequently induced by i.v. administration of L-lactic acid. Calves were then randomly assigned to receive either HSB (8.4% NaHCO3; 5 ml/kg over 5 minutes, i.v.; n=5) or no treatment (controls, n=5) and monitored for 1 hour. Mixed respiratory and strong ion acidosis was accompanied by increased heart rate, cardiac index, mean arterial pressure, cardiac contractility (maximal rate of change of left ventricular pressure), and mean pulmonary artery pressure. Rapid administration of HSB immediately corrected the strong ion acidosis, transiently increased arterial partial pressure of carbon dioxide (P(CO2)), and expanded the plasma volume. The transient increase in arterial P(CO2) did not alter CSF P(CO2) or induce paradoxical CSF acidosis. Compared to untreated control calves, HSB-treated calves had higher cardiac index and contractility and a faster rate of left ventricular relaxation for 1 hour after treatment, indicating that HSB administration improved myocardial systolic function. We conclude that rapid i.v. administration of HSB provided an effective and safe method for treating strong ion acidosis in normovolemic halothane-anesthetized calves with experimentally induced respiratory and strong ion acidosis. Fear of inducing paradoxical CSF acidosis is not a valid reason for withholding HSB administration in calves with mixed respiratory and strong ion acidosis.
authors.affiliation: Department of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.
authors.forename: Joachim F
authors.initials: JF
authors.lastname: Berchtold
authors.forename: Peter D
authors.initials: PD
authors.lastname: Constable
authors.forename: Geoffrey W
authors.initials: GW
authors.lastname: Smith
authors.forename: Sheerin M
authors.initials: SM
authors.lastname: Mathur
authors.forename: Dawn E
authors.initials: DE
authors.lastname: Morin
authors.forename: William J
authors.initials: WJ
authors.lastname: Tranquilli
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000138:Acidosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000662:veterinary*; D000142:Acidosis, Respiratory / Q000662:veterinary; D000818:Animals; D001784:Blood Gas Analysis; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D006863:Hydrogen-Ion Concentration; D006982:Hypertonic Solutions / Q000008:administration & dosage; D007262:Infusions, Intravenous / Q000662:veterinary; D008297:Male; D017693:Sodium Bicarbonate / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D006982:Hypertonic Solutions; D017693:Sodium Bicarbonate