Systemic T-cell activation in acute clinically isolated optic neuritis.
We examined untreated 60 patients with acute monosymptomatic optic neuritis (ON). Patients examined early after onset showed increased expression of HLA-DR and CD45R0 on CD4 and CD8 T cells. Expression of HLA-DR on CD4 T cells was higher in patients without IgG oligoclonal bands. Expression of HLA-DR on CD4 and CD8 T cells correlated negatively with measures of disease activity and positively with measures of good visual function, and expression of CD45R0 on CD4 T cells correlated negatively with measures of disease activity. We hypothesize that HLA-DR expression may characterize a protective T-cell subset in ON.
Roed
Hanne
H
The MS Clinic, Department of Neurology, University of Copenhagen, Glostrup Hospital, DK-2600 Glostrup, Denmark. roeden@dadlnet.dk
Frederiksen
Jette
J
Langkilde
Annika
A
Sørensen
Torben Lykke
TL
Lauritzen
Martin
M
Sellebjerg
Finn
F
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology*; D018414:CD8-Positive T-Lymphocytes / Q000502:physiology*; D005074:Evoked Potentials, Visual / Q000502:physiology; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D005786:Gene Expression Regulation / Q000502:physiology; D006684:HLA-DR Antigens / Q000097:blood / Q000134:cerebrospinal fluid; D006801:Humans; D017493:Leukocyte Common Antigens / Q000097:blood / Q000134:cerebrospinal fluid; D008213:Lymphocyte Activation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009902:Optic Neuritis / Q000097:blood / Q000134:cerebrospinal fluid / Q000473:pathology* / Q000503:physiopathology; D014785:Vision, Ocular / Q000502:physiology
D006684:HLA-DR Antigens; D017493:Leukocyte Common Antigens