Antioxidant activities of three dihydrochalcone glucosides from leaves of Lithocarpus pachyphyllus.
In vitro antioxidant activities of three sweet dihydrochalcone glucosides from the leaves of Lithocarpus pachyphyllus (Kurz) Rehd. (Fagaceae), trilobatin 2"-acetate (1), phloridzin (2) and trilobatin (3), were investigated. The IC50 (50% inhibitory concentration) values for compounds 1-3 of lipid peroxidation in rat liver homogenate were 261, 28, 88 microM, respectively. Compounds 1-3 increased superoxide dismutase (SOD) activity with EC50 (50% effective concentration) values of 575, 167, 128 microM, and glutathione peroxidase (GSH-Px) activity with EC50 values of 717, 347, 129 microM, respectively, and showed only weak DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity.
Yang
Wei-Min
WM
Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming 650204, P R China.
Liu
Ji-Kai
JK
Qin
Xiang-Dong
XD
Wu
Wan-Lin
WL
Chen
Zhi-He
ZH
D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification* / Q000494:pharmacology; D001713:Biphenyl Compounds; D002599:Chalcone / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D047188:Chalcones; D029962:Fagaceae / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005960:Glucosides; D005979:Glutathione Peroxidase / Q000378:metabolism; D006834:Hydrazines; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D010851:Picrates; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D001713:Biphenyl Compounds; D047188:Chalcones; D016166:Free Radical Scavengers; D005960:Glucosides; D006834:Hydrazines; D010851:Picrates; D002599:Chalcone; C004931:1,1-diphenyl-2-picrylhydrazyl; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; C015812:dihydrochalcone