Risk factors of long-term survival and recurrence after curative resection of hepatocellular carcinoma.
OBJECTIVE
The independent risk factors contributing to long-term survival (> or = 10-year survival rate) and recurrence after curative hepatic resection for hepatocellular carcinoma (HCC) were evaluated.


METHODS
The prognoses were retrospectively analyzed in 247 consecutive patients (187 men and 60 women) treated with curative hepatic resection for HCC and discharged from the hospital. Prognostic factors were evaluated by multivariate analysis using Cox's proportional hazards model.


RESULTS
Multivariate analysis revealed that pTNM stage IV, indocyanine green retention rate at 15 minutes (ICGR15) of > or = 20%, tumor size of > or = 5 cm, and positive hepatitis B surface antigen were independent risk factors of overall survival. Stage IV and ICGR15 of > or = 20% were also independent risk factors of disease-free survival.


CONCLUSIONS
pTNM stage and ICGR15 may be simple and useful predictors to improve long-term survival and recurrence after curative hepatic resection for HCC.
Hanazaki
Kazuhiro
K
Second Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan. hanayan@hsp.md.shinshu-u.ac.jp
Matsushita
Akimasa
A
Nakagawa
Kan
K
Misawa
Ryosuke
R
Amano
Jun
J
D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology / Q000601:surgery* / Q000821:virology; D004396:Coloring Agents / Q000493:pharmacokinetics; D005260:Female; D006498:Hepatectomy; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006801:Humans; D007208:Indocyanine Green / Q000493:pharmacokinetics; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000209:etiology*; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D013997:Time Factors
D004396:Coloring Agents; D006514:Hepatitis B Surface Antigens; D007208:Indocyanine Green