title: [Orthotopic liver transplantation in adult patients with cadaveric grafts. Experience of the Fundeni Center of General Surgery and Liver Transplantation].
abstract: We analyze the experience of the Center of General Surgery and Liver Transplantation from the Fundeni Clinical Institute (Bucharest, Romania) regarding orthotopic liver transplantation (OLT) in adult recipients, with whole liver grafts from cadaveric donors, between April 2000 (when the first successful LT was performed in Romania) and December 2004. This series includes 37 OLTs in adult recipients (16 women and 21 men, aged between 29-57 years--average 46 years). Other two LT with whole liver cadaveric grafts and two reduced-size LT were performed in children; also, in the same period, due to the acute organ shortage, other methods of LT were performed in 28 patients (21 living donor LT, 6 split LT and one "do mino" LT), that were not included in the present series. The indications for OLT were HBV cirrhosis--10, HBV+HDV cirrhosis--4, HCV cirrhosis--11, HBV+HCV cirrhosis--2, biliary cirrhosis--5, Wilson disease--2, alcoholic cirrhosis--1, non-alcoholic liver disease--1, autoimmune cirrhosis--1. With three exceptions, in which the classical transplantation technique was used, the liver was grafted following the technique described by Belghiti. Local postoperative complications occurred in 15 patients (41%) and general complications in 17 (46%); late complications were registered in 18 patients (49%) and recurrence of the initial disease in 6 patients (16%). Intrao- and postoperative mortality was 8% (3/37). There were two patients (5%) who died because of immunosuppressive drug neurotoxicity at more than 30 days following LT. Four patients (11%) died lately because of PTLD, liver venoocclusive disease, recurrent autoimmune hepatitis and liver venoocclusive disease, myocardial infarction, respectively. Thirty-four patients survived the postoperative period (92%); according to Kaplan-Meier analysis, actuarial patient-survival rate at month 31 was 75%.
authors.affiliation: Centrul de Chirurgie Generală si Transplant Hepatic, Institutul Clinic Fundeni, Bucureşti. irinel.popescu@icfundeni.ro
authors.forename: I
authors.initials: I
authors.lastname: Popescu
authors.forename: M
authors.initials: M
authors.lastname: Ionescu
authors.forename: D
authors.initials: D
authors.lastname: Tulbure
authors.forename: S
authors.initials: S
authors.lastname: Ciurea
authors.forename: S
authors.initials: S
authors.lastname: Băilă
authors.forename: V
authors.initials: V
authors.lastname: Braşoveanu
authors.forename: D
authors.initials: D
authors.lastname: Hrehoreţ
authors.forename: P
authors.initials: P
authors.lastname: Sârbu-Boeţi
authors.forename: D
authors.initials: D
authors.lastname: Pietrăreanu
authors.forename: S
authors.initials: S
authors.lastname: Alexandrescu
authors.forename: B
authors.initials: B
authors.lastname: Dorobanţu
authors.forename: L
authors.initials: L
authors.lastname: Gheorghe
authors.forename: C
authors.initials: C
authors.lastname: Gheorghe
authors.forename: M
authors.initials: M
authors.lastname: Mihăilă
authors.forename: M
authors.initials: M
authors.lastname: Boroş
authors.forename: M
authors.initials: M
authors.lastname: Croitoru
authors.forename: V
authors.initials: V
authors.lastname: Herlea
mesh_terms: D000328:Adult; D002102:Cadaver; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000601:surgery; D016031:Liver Transplantation / Q000379:methods / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology; D012189:Retrospective Studies; D018570:Risk Assessment; D012383:Romania / Q000453:epidemiology; D016019:Survival Analysis; D015996:Survival Rate