Synthesis and antimycobacterial activity of ferrocenyl ethambutol analogues and ferrocenyl diamines.
A new series of ferrocenyl diamino alcohols and diamines were synthesized and their inhibitory potencies were probed with Mycobacterium tuberculosis. Interestingly, ferrocenyl diamines 6a and b display significant activities against M. tuberculosis H37Rv.
Razafimahefa
Dorothée
D
Laboratoire de Chimie Appliquée aux Substances Naturelles, Faculté des Sciences d'Antananarivo, B.P. 906, 101 Antananarivo, Madagascar.
Ralambomanana
Dimby Andrianina
DA
Hammouche
Lies
L
Pélinski
Lydie
L
Lauvagie
Sylvia
S
Bebear
Christiane
C
Brocard
Jacques
J
Maugein
Jeanne
J
D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D003959:Diamines / Q000138:chemical synthesis / Q000494:pharmacology; D004977:Ethambutol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D005296:Ferrous Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000995:Antitubercular Agents; D003959:Diamines; D005296:Ferrous Compounds; D004977:Ethambutol