[Expression and significance of nuclear factor kappaB in laryngeal carcinoma].
OBJECTIVE
To explore the expression and significance of NF-kappaB in laryngeal carcinoma.


METHODS
The protein expression of NF-kappaB p65 in laryngeal carcinoma tissue and normal laryngeal tissue was examined by Western blot; NF-kappaB DNA binding activity was examined by electrophoretic motility shift assay (EMSA) in 20 laryngeal carcinoma tissue and 12 normal laryngeal tissue.


RESULTS
The levels of NF-kappaB p65 protein and NF-kappaB DNA binding activity in the laryngeal carcinoma tissue were higher than those in normal laryngeal tissue.


CONCLUSIONS
NF-kappaB may be an important oncoprotein and involves in the occurrence and development of laryngeal carcinoma.
Zhu
Jiang
J
Department of Otolaryngology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Hu
Guohua
G
Sun
Yucai
Y
D006801:Humans; D007820:Laryngeal Mucosa / Q000378:metabolism; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D051996:Transcription Factor RelA / Q000096:biosynthesis*
D051996:Transcription Factor RelA