Coronary flow velocity reserve is diminished in hypertensive left ventricular hypertrophy.
BACKGROUND
Dipyridamole stress transesophageal echocardiography (STEE) is a feasible method for the evaluation of coronary flow velocity reserve (CFR).


OBJECTIVE
The aim of the present study was to investigate CFR in hypertensive patients with or without left ventricular hypertrophy (LVH).


METHODS
The study comprised 73 patients with a negative coronary angiogram (29 men and 44 women). Three different groups were compared: normotensive patients, hypertensive patients without LVH and hypertensive patients with LVH.


RESULTS
CFR was significantly decreased in patients with hypertension with LVH as compared to normotensive cases (2.19+/-0.50 vs 2.71+/-1.10; p<0.05). CFR of hypertensive patients without LVH was only slightly reduced as compared to normotensive cases (2.44+/-0.81 vs 2.71+/-1.10; p=ns). In hypertensive patients with LVH, the LV mass and LV mass index were inversely related to CFR (r = -0.481 and -0.477, p<0.05, respectively).


CONCLUSIONS
CFR is diminished in patients with hypertension. The degree of CFR reduction is related to the extent of LVH.
Nemes
Attila
A
2nd Department of Medicine and Cardiology Centre, University of Szeged, Hungary.
Neu
Klara
K
Forster
Tamas
T
Kovacs
Zsolt
Z
Csanady
Miklos
M
D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D016022:Case-Control Studies; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000187:drug effects; D004176:Dipyridamole / Q000494:pharmacology; D025401:Echocardiography, Stress; D017548:Echocardiography, Transesophageal; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000209:etiology* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D014665:Vasodilator Agents / Q000494:pharmacology
D014665:Vasodilator Agents; D004176:Dipyridamole