Structure and unique interactions with DNA of a cationic trans-platinum complex with the nonplanar bicyclic piperidinopiperidine ligand.
Najajreh
Yousef
Y
Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.
Prilutski
Dmitri
D
Ardeli-Tzaraf
Yael
Y
Perez
Jose Manuel
JM
Khazanov
Elena
E
Barenholz
Yechezkel
Y
Kasparkova
Jana
J
Brabec
Viktor
V
Gibson
Dan
D
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry*; D018736:DNA Adducts / Q000737:chemistry; D006801:Humans; D020128:Inhibitory Concentration 50; D008024:Ligands; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000138:chemical synthesis*; D010880:Piperidines / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry*
C105149:4-(1-piperidino)piperidine; D000970:Antineoplastic Agents; D018736:DNA Adducts; D008024:Ligands; D009944:Organoplatinum Compounds; D010880:Piperidines; D010984:Platinum; D004247:DNA; D002945:Cisplatin