title: 5-fluorocytosine and amphotericin B in bronchial secretions.
abstract: The penetration into and clearance from bronchial secretions of 5-fluorocytosine and amphotericin B were studied in a dog model. After a single intravenous dose of 35 mg/kg, 5-fluorocytosine intrabronchial concentrations were greater than the minimal inhibitory concentration for 80 to 90% of Candida species. These inhibitory concentrations persisted up to 3 h. In contrast, amphotericin B in intravenous doses of 0.6 and 1.2 mg/kg penetrated the blood-bronchus barrier poorly.
authors.forename: J E
authors.initials: JE
authors.lastname: Pennington
authors.forename: E R
authors.initials: ER
authors.lastname: Block
authors.forename: H Y
authors.initials: HY
authors.lastname: Reynolds
mesh_terms: D000666:Amphotericin B / Q000493:pharmacokinetics*; D000818:Animals; D000935:Antifungal Agents / Q000493:pharmacokinetics*; D001980:Bronchi / Q000378:metabolism*; D004285:Dogs; D005437:Flucytosine / Q000493:pharmacokinetics*
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D005437:Flucytosine