title: Analysis of factors influencing hepatocellular carcinoma detection: efficient use of computed tomography during arterial portography and during hepatic arteriography.
abstract: BACKGROUND
  This study was performed to investigate the situations in which computed tomography (CT) combined with arterial portography and hepatic arteriography surpassed dynamic CT in the detection of hepatocellular carcinoma.
  
  
  METHODS
  Computed tomography combined with arterial portography and hepatic arteriography was performed on 137 patients with chronic hepatitis (92 men and 45 women; mean age, 66.5 years) with hepatocellular carcinoma (HCC) as revealed or suspected by dynamic CT. We analyzed the clinical factors leading to the discovery of additional HCC lesions on CT combined with arterial portography and hepatic arteriography that were undetected by dynamic CT.
  
  
  RESULTS
  Computed tomography combined with arterial portography and hepatic arteriography detected additional HCC lesions that had not been revealed by dynamic CT in 33 of 137 patients. Univariate analysis revealed that in the event of HCC recurrence (vs. primary), multiple HCC lesions detected by dynamic CT (vs. single) and decreased liver function (Child's classification B/C vs. A) significantly favored the additional detection of HCC lesions. Multivariate logistic regression indicated that recurrence was the strongest predicting factor for finding additional lesions on computed tomography combined with arterial portography and hepatic arteriography.
  
  
  CONCLUSIONS
  Computed tomography combined with arterial portography and hepatic arteriography is capable of finding additional HCC lesions undetectable by dynamic CT, especially in advanced cases such as HCC recurrence, which may affect the choice of treatment.
authors.affiliation: Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Fujishima
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Yoshida
authors.forename: Shuntaro
authors.initials: S
authors.lastname: Obi
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Shiina
authors.forename: Miho
authors.initials: M
authors.lastname: Kanda
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Tateishi
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Akamatsu
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Koike
authors.forename: Shinpei
authors.initials: S
authors.lastname: Sato
authors.forename: Takuma
authors.initials: T
authors.lastname: Teratani
authors.forename: Takao
authors.initials: T
authors.lastname: Kawabe
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Shiratori
authors.forename: Masao
authors.initials: M
authors.lastname: Omata
mesh_terms: D000368:Aged; D000792:Angiography / Q000379:methods*; D001706:Biopsy; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000473:pathology; D003287:Contrast Media / Q000008:administration & dosage; D003937:Diagnosis, Differential; D005260:Female; D006499:Hepatic Artery; D006801:Humans; D007269:Injections, Intra-Arterial; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008638:Mesenteric Arteries; D008875:Middle Aged; D011172:Portography / Q000379:methods*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014463:Ultrasonography
chemical_list: D003287:Contrast Media