Pediatric refractory partial status epilepticus responsive to topiramate.
Topiramate was safely administered to two young children with refractory partial status epilepticus via nasogastric tube in rapid titration up to a very high total daily dose. An excellent clinical response occurred in both cases. Reaching high daily doses of topiramate within days allowed for safe discontinuation of other antiepileptic drugs in both patients. Given the high efficacy of rapidly titrated topiramate in our patients, this medication may be useful in some cases of pediatric refractory partial status epilepticus. However, more clinical studies on this therapeutic approach are needed to establish the precise role of topiramate in status epilepticus in children.
Blumkin
Lubov
L
Pediatric Neurology Unit, Wolfson Medical Center, Holon, Israel.
Lerman-Sagie
Tally
T
Houri
Tzion
T
Gilad
Eli
E
Nissenkorn
Andrea
A
Ginsberg
Mira
M
Watemberg
Nathan
N
D000927:Anticonvulsants / Q000008:administration & dosage*; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005260:Female; D005632:Fructose / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D013226:Status Epilepticus / Q000188:drug therapy*; D000077236:Topiramate
D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose