Development of new calcium receptors based on oxazolidin-2-ones containing pseudopeptides.
With the aim of designing a new calcium receptor, the synthesis and the conformational analysis of a small library of dipeptides having the general formula Ac-Oxx-L-Xaa-OBn [Oxx = L-Oxd, (4S,5R)-4-methyl-5-carboxyoxazolidin-2-one; D-Oxd, (4R,5S)-4-methyl-5-carboxyoxazolidin-2-one; or D-Oxac (4R)-(2-oxo-1,3-oxazolidin-4-yl)-acetic acid] is reported. Ac-L-Oxd-L-Ala-OBn was identified as the most promising compound by MS-ESI analysis and this outcome was confirmed by photoluminescence spectroscopy.
Luppi
Gianluigi
G
Dipartimento di Chimica G. Ciamician - Alma Mater Studiorum, Universita di Bologna, Italy.
Garelli
Andrea
A
Prodi
Luca
L
Broxterman
Quirinus B
QB
Kaptein
Bernard
B
Tomasini
Claudia
C
D002118:Calcium / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D023303:Oxazolidinones / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D011522:Protons; D044169:Receptors, Calcium-Sensing / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
D023303:Oxazolidinones; D010455:Peptides; D011522:Protons; D044169:Receptors, Calcium-Sensing; D002118:Calcium