title: Corneal thickness and functional damage in patients with ocular hypertension.
abstract: OBJECTIVE
  To correlate functional damage over time detected by standard automated perimetry (SAP) and frequency doubling technology (FDT) with central corneal thickness (CCT) in patients with ocular hypertension (OHT).
  
  
  METHODS
  Seventy-eight OHT patients underwent CCT measurements, SAP, and FDT (the latter two also after 12 and 18 months). Patients were divided into three equally sized groups of 26 patients each: thin (< 540 microm), normal (540-580 microm), and thick cornea (> 580 microm). The frequency of abnormal FDT and SAP results was analyzed over time (Pearson chi2 test).
  
  
  RESULTS
  Six of 26 patients with thin corneas (23.1%) presented an abnormal FDT test at baseline, compared to 1 of 26 (3.8%) in the normal thickness cornea group and 1 of 26 (3.8%) in the thick cornea group. After 12 months, the abnormal FDT tests were as follows, respectively: 9 of 26 (34.6%), 2 of 26 (7.7%), and 2 of 26 (7.7%). For SAP the abnormal results were as follows, respectively: 8 (30.1%), 5 (19.2%), and 2 (7.7%). After 18 months, the abnormal FDT tests were as follows, respectively: 16 (61.5%), 5 (19.2%), and 5 (19.2%). For SAP, the abnormal results were as follows, respectively: 10 (38.5%), 5 (19.2%), and 2 (7.7%).
  
  
  CONCLUSIONS
  OHT patients with thinner corneas have a greater risk of developing functional damage over time.
authors.affiliation: Department of Ophthalmology, Santa Maria della Misericordia Hospital, Udine, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Zeppieri
authors.forename: P
authors.initials: P
authors.lastname: Brusini
authors.forename: S
authors.initials: S
authors.lastname: Miglior
mesh_terms: D000328:Adult; D000368:Aged; D001837:Body Weights and Measures; D003315:Cornea / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000503:physiopathology*; D012165:Retinal Ganglion Cells / Q000502:physiology; D014786:Vision Disorders / Q000503:physiopathology*; D058609:Visual Field Tests / Q000379:methods; D014794:Visual Fields / Q000502:physiology*