title: Investigation of peptide YY and ghrelin responses to a test meal in bulimia nervosa.
abstract: BACKGROUND
  Gut-derived peptides, such as peptide YY (PYY) and ghrelin that regulate the initiation and termination of meals, could play a role in the altered eating behavior of patients with bulimia nervosa (BN). Therefore, we aimed to assess plasma PYY and ghrelin responses to a test meal in symptomatic bulimics.
  
  
  METHODS
  Ten healthy women and nine women with BN underwent blood sample collections before and after the ingestion of a test meal of 1300 Kcal (with 15% carbohydrates, 10% proteins, and 75% fat) at 12:00 noon. Plasma total PYY, ghrelin, insulin, and glucose were assayed.
  
  
  RESULTS
  As compared with healthy women, bulimics exhibited a significantly blunted increase of circulating PYY (p < .007) and a significantly reduced suppression of plasma ghrelin (p < .0004) after the test meal. No significant differences emerged in food-induced plasma insulin and glucose changes between the two groups. Plasma ghrelin suppression after the meal was significantly correlated with plasma PYY increase.
  
  
  CONCLUSIONS
  We replicated our previous findings of an altered ghrelin response to food ingestion in people with BN and showed for the first time a blunted PYY increase after food consumption in these patients. These findings support the occurrence in BN of a profound dysregulation of some peripheral regulatory mechanisms involved in the short-term regulation of feeding behavior that might be involved in the pathophysiology of their binge eating behavior.
authors.affiliation: Department of Psychiatry, University of Naples SUN, Naples, Italy. monteri@tin.it
authors.forename: Palmiero
authors.initials: P
authors.lastname: Monteleone
authors.forename: Vassilis
authors.initials: V
authors.lastname: Martiadis
authors.forename: Antonello E
authors.initials: AE
authors.lastname: Rigamonti
authors.forename: Michele
authors.initials: M
authors.lastname: Fabrazzo
authors.forename: Claudio
authors.initials: C
authors.lastname: Giordani
authors.forename: Eugenio E
authors.initials: EE
authors.lastname: Muller
authors.forename: Mario
authors.initials: M
authors.lastname: Maj
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition; D015992:Body Mass Index; D002032:Bulimia / Q000378:metabolism*; D004041:Dietary Fats / Q000494:pharmacology; D004435:Eating / Q000502:physiology*; D005260:Female; D054439:Ghrelin; D006801:Humans; D007328:Insulin / Q000097:blood; D009747:Nutritional Physiological Phenomena; D036361:Peptide Hormones / Q000378:metabolism*; D019894:Peptide YY / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D054439:Ghrelin; D007328:Insulin; D036361:Peptide Hormones; D019894:Peptide YY