[Study on single nucleotide polymorphism of beta2 adrenoceptor gene in patients with pregnancy induced hypertension of northern China].
OBJECTIVE
To study the association of single nucleotide polymorphism (SNP) at locus +46 of human beta(2)-adrenoceptor (beta(2)-AR) gene with pregnancy induced hypertension (PIH) in women from northern China.


METHODS
One hundred and eight women with PIH (PIH group) and ninety seven normal pregnant women (control group) were selected. SNP at locus +46 of human beta(2)-AR was genotyped using PCR-based restriction fragment length polymorphism (RFLP) method.


RESULTS
(1) The frequencies of AA, AG and GG genotypes beta(2)-AR at locus +46 were 24.1%, 25.0% and 50.9% in PIH group, respectively. They were 24.7%, 29.9%, and 45.4% in control group, respectively (P > 0.05). The frequencies of the two alleles A and G were 36.6%, 63.4% in PIH group, and 39.7% and 60.3% in control group, respectively (P > 0.05). (2) There was a significant difference in the distribution frequency of beta(2)-AR at locus +46 between mild, moderate and severe degrees of PIH (P < 0.05).


CONCLUSIONS
It indicates that, SNP at locus +46 of beta(2)-AR gene is not associated with generation of PIH in northern China, but it has an association with the severity of PIH.
Fan
Li-mei
LM
Department of Obstetrics and Gynecology, Second Hospital, Jilin University, Changchun 130041, China.
Zhang
Wei-yuan
WY
Zhao
Yan-hui
YH
Shi
Jie-ping
JP
D000328:Adult; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000379:methods; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011247:Pregnancy; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*
D018343:Receptors, Adrenergic, beta-2