Pediatric reference intervals for FSH, LH, estradiol, T3, free T3, cortisol, and growth hormone on the DPC IMMULITE 1000.
BACKGROUND
We studied serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), triiodothyronine (T3), free T3 (FT3), cortisol and growth hormone (GH) concentrations in a population of pediatric patients. The reference intervals were determined separately for females and males stratified by age groups to assess age- and sex-related differences. Our objective was to obtain reference intervals for the 7 serum analytes for our pediatric population using the IMMULITE 1000 system.


METHODS
Serum samples of 800 in- and out-patients, newborn to 19 years old were analyzed using the DPC IMMULITE 1000 chemiluminescent immunoassay system.


CONCLUSIONS
We report pediatric reference intervals for FSH, LH, E2, T3, FT3, cortisol, and GH. These reference intervals provide the basis for clinical interpretation of laboratory results using the IMMULITE 1000 system and the assessment of child development.
Soldin
Offie P
OP
Division of Endocrinology and Metabolism, Georgetown University School of Medicine, Washington DC 20057-1465, USA.
Hoffman
Eve G
EG
Waring
Michael A
MA
Soldin
Steven J
SJ
D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D004958:Estradiol / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007118:Immunoassay / Q000379:methods; D007223:Infant; D007231:Infant, Newborn; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D012016:Reference Values; D015203:Reproducibility of Results; D014284:Triiodothyronine / Q000097:blood*
D014284:Triiodothyronine; D019382:Human Growth Hormone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D006854:Hydrocortisone