title: [Expression and significance of nuclear factor kappaB in laryngeal carcinoma].
abstract: OBJECTIVE
  To explore the expression and significance of NF-kappaB in laryngeal carcinoma.
  
  
  METHODS
  The protein expression of NF-kappaB p65 in laryngeal carcinoma tissue and normal laryngeal tissue was examined by Western blot; NF-kappaB DNA binding activity was examined by electrophoretic motility shift assay (EMSA) in 20 laryngeal carcinoma tissue and 12 normal laryngeal tissue.
  
  
  RESULTS
  The levels of NF-kappaB p65 protein and NF-kappaB DNA binding activity in the laryngeal carcinoma tissue were higher than those in normal laryngeal tissue.
  
  
  CONCLUSIONS
  NF-kappaB may be an important oncoprotein and involves in the occurrence and development of laryngeal carcinoma.
authors.affiliation: Department of Otolaryngology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Zhu
authors.forename: Guohua
authors.initials: G
authors.lastname: Hu
authors.forename: Yucai
authors.initials: Y
authors.lastname: Sun
mesh_terms: D006801:Humans; D007820:Laryngeal Mucosa / Q000378:metabolism; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D051996:Transcription Factor RelA / Q000096:biosynthesis*
chemical_list: D051996:Transcription Factor RelA