title: Detection of cortical activation with time-resolved diffuse optical methods.
abstract: Simulations based on diffusion theory that use a finite-element method and rely on an magnetic resonance imaging head model suggest that time-resolved diffuse optical techniques could provide information about the depth at which variations in perfusion take place and improve the detection of cortical activation. Experimental investigations were performed with sequentially driven picosecond laser diodes and an eight-channel time-correlated single-photon-counting detection system. The experimental results obtained for activation in the motor cortex, and for the Valsalva maneuver, confirm our assumptions and are in good agreement with the simulated data.
authors.affiliation: Institut de Physique Biologique, Université Louis Pasteur of Strasbourg, Unité Mixte de Recherche 7004, Centre National de la Recherche Scientifique, 4 rue Kirschleger, 67085 Strasbourg, France. montcel@ipb.u-strasbg.fr
authors.forename: Bruno
authors.initials: B
authors.lastname: Montcel
authors.forename: Renee
authors.initials: R
authors.lastname: Chabrier
authors.forename: Patrick
authors.initials: P
authors.lastname: Poulet
mesh_terms: D000465:Algorithms; D001931:Brain Mapping / Q000379:methods*; D002540:Cerebral Cortex / Q000033:anatomy & histology* / Q000502:physiology*; D003198:Computer Simulation; D019054:Evoked Potentials, Motor / Q000502:physiology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008959:Models, Neurological; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D041622:Tomography, Optical / Q000379:methods*