title: Activity-dependent adjustments of the inhibitory network in the olfactory bulb following early postnatal deprivation.
abstract: The first-order sensory relay for olfactory processing, the main olfactory bulb (MOB), retains the ability to acquire new interneurons throughout life. It is therefore a particularly appropriate region for studying the role of experience in sculpting neuronal networks. We found that nostril closure decreased the number of newborn granule cells in the MOB, the complexity of their dendritic arborization, and their spine density, without affecting the preexisting population of granule cells. Accordingly, the frequency of miniature synaptic inhibitory events received by mitral cells was reduced. However, due to a compensatory increase in newborn granule cell excitability, action potential-dependent GABA release was dramatically enhanced, thus counteracting the reduction in spine density and leading to an unaltered synchronization of mitral cell firing activity. Together, this study reveals a unique form of adaptive response brought about exclusively by the cohort of newborn cells and used to maintain normal functioning of the MOB.
authors.affiliation: Laboratory of Perception and Memory, Pasteur Institute, Centre National de la Recherche, Scientifique (URA 2182), 75015 Paris Cedex, France.
authors.forename: Armen
authors.initials: A
authors.lastname: Saghatelyan
authors.forename: Pascal
authors.initials: P
authors.lastname: Roux
authors.forename: Michele
authors.initials: M
authors.lastname: Migliore
authors.forename: Christelle
authors.initials: C
authors.lastname: Rochefort
authors.forename: David
authors.initials: D
authors.lastname: Desmaisons
authors.forename: Pierre
authors.initials: P
authors.lastname: Charneau
authors.forename: Gordon M
authors.initials: GM
authors.lastname: Shepherd
authors.forename: Pierre-Marie
authors.initials: PM
authors.lastname: Lledo
mesh_terms: D000818:Animals; D009433:Neural Inhibition / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D009812:Odorants; D009830:Olfactory Bulb / Q000166:cytology / Q000254:growth & development*; D009831:Olfactory Mucosa / Q000294:innervation; D051381:Rats; D012683:Sensory Deprivation / Q000502:physiology*