In vitro uptake of isometamidium and diminazene by Trypanosoma brucei.
The cattle trypanocide, isometamidium, was readily taken up by inactivated Trypanosoma brucei, while its uptake by living parasites was reduced or inhibited by plasma. In both respects isometamidium differs from diminazene.
Girgis-Takla
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P
James
D M
DM
D000818:Animals; D004133:Diminazene / Q000493:pharmacokinetics*; D006801:Humans; D010617:Phenanthridines / Q000493:pharmacokinetics*; D014344:Trypanocidal Agents / Q000493:pharmacokinetics*; D014346:Trypanosoma brucei brucei / Q000378:metabolism*
D010617:Phenanthridines; D014344:Trypanocidal Agents; C000702:isometamidium chloride; D004133:Diminazene