CNS pharmacological effects of the hydroalcoholic extract of Sida cordifolia L. leaves.
Sida cordifolia L. (Malvaceae), known as "malva branca", is a plant used in the popular medicine for the treatment stomatits, of asthma and nasal congestion. This work researched the acute toxicity of Sida cordifolia and its action on the central nervous system (CNS) because no data in the literature have been found about of pharmacological activity of this plant in the CNS. The hydroalcoholic extract of Sida cordifolia leaves (HESc) was used and the psychopharmacology approach began with the determination of LD(50), where a low toxicity was observed in mice. Depressive activity on CNS was demonstrated by several alterations in mice's behavior in the pharmacological screening. In the motility test, the HESc showed significant reduction of spontaneous activity at a dose of 1000 mg/kg (i.p.) at 30 and 60 min. The same form the HESc also decreased the ambulation and rearing in open-field test at 30, 60 and 120 min at a dose of 1000 mg/kg (i.p.).
Franco
C I F
CI
Laboratório de Tecnologia Farmacêutica e Departamento de Fisiologia e Patologia, Universidade Federal da Paraíba, Caixa Postal 5009, CEP: 58051-970 João Pessoa, PB, Brazil.
Morais
L C S L
LC
Quintans-Júnior
L J
LJ
Almeida
R N
RN
Antoniolli
A R
AR
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002490:Central Nervous System / Q000187:drug effects*; D003672:Defecation / Q000187:drug effects; D006120:Grooming / Q000187:drug effects; D007928:Lethal Dose 50; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D019660:Malvaceae; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D018515:Plant Leaves
D010936:Plant Extracts