title: [Malignant melanoma of nasal fossae: clinical and therapeutic considerations about three cases].
abstract: We report in this publication three cases of mucous malignant melanoma of the nasal fossae. The nasal mucous malignant melanoma creates a unilateral obstructive and hemorrhagic tumour, readily septal or situated on the external wall of the nasal fossae (inferior and middle turbinates). The diagnosis established by the clinical examination (pigmented forms) is confirmed by the anatomopathological examination--thanks in particular to its tinctorial affinity for Fontana-Masson colouring. The immunohistochemistry reinforces the diagnosis in the presence of any achromic varieties or those simulating an undifferentiated tumour or neurinoma. Modern imagery (CT Scan, IRM) is impossible to circumvent for a precise loco-regional assessment, an essential preliminary to the therapeutic protocol--mainly of radiosurgical type. Chemotherapy (deticene) remains in force in the metastatic forms. Specific therapies are being evaluated (immunological-hormonal therapy). The forecast of the mucous malignant melanoma remains pejorative with a 10 to 40% survival rate of five years. The improvement of the forecast depends on an early diagnosis, an evolutionary locoregional assessment as complete as possible with an adapted and multidisciplinary choice of therapies (surgery, radiotherapy, immunotherapy, hormonal therapy).
authors.affiliation: ORL des hôpitaux, 1, rue Chenafi-Mohamed, 23000 Annaba, Algérie. s_kharoubi@yahoo.fr
authors.forename: S
authors.initials: S
authors.lastname: Kharoubi
mesh_terms: D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D001706:Biopsy; D003131:Combined Modality Therapy; D003606:Dacarbazine / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D008875:Middle Aged; D009297:Nasal Mucosa / Q000473:pathology; D009300:Nasal Septum / Q000473:pathology; D009362:Neoplasm Metastasis; D009669:Nose Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D011379:Prognosis; D011879:Radiotherapy Dosage; D013997:Time Factors; D014420:Turbinates / Q000473:pathology
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003606:Dacarbazine