title: Gonadal dysfunction in systemic diseases.
abstract: Gonadal function is significantly affected in many acute and chronic systemic diseases. As the function of the testes and the ovaries is determined by the integrity of the hypothalamic-pituitary-gonadal axis, it is obvious that a systemic disease may affect one or more levels of the axis in such a manner that the gonadal dysfunction may have various clinical and laboratory manifestations. In this brief review, the most common disturbances seen in the main systemic diseases will be discussed.
authors.affiliation: Second Propedeutic Department of Internal Medicine, Division of Endocrinology, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Greece. astkar@med.auth.gr
authors.forename: Asterios
authors.initials: A
authors.lastname: Karagiannis
authors.forename: Faidon
authors.initials: F
authors.lastname: Harsoulis
mesh_terms: D002318:Cardiovascular Diseases / Q000503:physiopathology; D002446:Celiac Disease / Q000503:physiopathology; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000503:physiopathology; D008104:Liver Cirrhosis, Alcoholic / Q000503:physiopathology; D008107:Liver Diseases / Q000503:physiopathology; D008297:Male; D024821:Metabolic Syndrome / Q000503:physiopathology; D010053:Ovary / Q000503:physiopathology*; D012216:Rheumatic Diseases / Q000503:physiopathology; D013737:Testis / Q000503:physiopathology*; D013739:Testosterone / Q000502:physiology
chemical_list: D013739:Testosterone