Can we improve the management of blood donors with nonspecific reactivity in viral screening and confirmatory assays?
Donors with nonspecific reactivity in viral screening or confirmatory assays are problematic for blood services because of donor management issues and product loss. Considerable experience has now accumulated in the use of screening and confirmatory assays; therefore, it is timely to examine the ways in which donors with nonspecific reactivity are managed. In this review, we summarize the causes and characteristics of nonspecific reactivity in blood donors and approaches for reducing the number of nonspecific reactive results and we offer some suggestions for improving the management of these donors.
Kiely
Philip
P
Virus Serology Laboratory, Australian Red Cross Blood Service, South Melbourne, Victoria 3205, Australia. pkiely@arcbs.redcross.org.au
Wood
Erica
E
D001782:Blood Donors; D005189:False Positive Reactions; D006678:HIV / Q000378:metabolism; D015368:Human T-lymphotropic virus 1 / Q000378:metabolism; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D008403:Mass Screening; D012367:RNA, Viral / Q000097:blood; D011933:Reagent Kits, Diagnostic; D012307:Risk Factors; D012680:Sensitivity and Specificity; D065227:Transfusion Reaction; D014777:Virus Diseases / Q000517:prevention & control* / Q000635:transmission*
D012367:RNA, Viral; D011933:Reagent Kits, Diagnostic