title: [Roles of PPAR family in bone metabolisms].
abstract: Bone is a complex tissue which contains osteoclasts, osteoblasts, chondrocytes, adipocytes, hematopoietic cells and immune cells. Since osteoblasts share the same origin with adipocytes in bone marrow cavity, it is assumed that PPAR (peroxisome proliferator-activated receptor) family, which is an important nuclear receptor family for adipocyte differentiation, plays a role in the bone microenvironment. Indeed, recent evidences support the primitive roles of PPAR family in osteoblast differentiation as well as adipocyte differentiation. Furthermore, PPAR family is also implicated in the regulation of differentiation and function of osteoclasts. Here, we summarized the functional roles of PPAR family in bone remodeling and regulation of bone microenvironments. We also discuss the potential mechanisms that regulate expression and function of PPAR family during bone metabolisms.
authors.affiliation: Department of Biochemistry, Osaka University Graduate School of Dentistry.
authors.forename: Riko
authors.initials: R
authors.lastname: Nishimura
authors.forename: Kenji
authors.initials: K
authors.lastname: Hata
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Ichida
mesh_terms: D000818:Animals; D016723:Bone Remodeling / Q000502:physiology; D001842:Bone and Bones / Q000378:metabolism*; D005801:Genes, Homeobox; D006412:Hematopoietic Stem Cells / Q000502:physiology; D051379:Mice; D010010:Osteoclasts / Q000502:physiology; D047492:Peroxisome Proliferator-Activated Receptors / Q000502:physiology*
chemical_list: D047492:Peroxisome Proliferator-Activated Receptors