Microbiological assays and bioautography of maytansine and its homologues.
A quantitative microbiological assay and a bioautography system with Penicillium avellaneum UC-4376 was developed for the antitumor drugs maytansine, and its homologues, maytanprine and maytanbutine. The susceptibility of the assay is 1.5 mug/ml.
Hanka
L J
LJ
Barnett
M S
MS
D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis*; D002845:Chromatography; D004305:Dose-Response Relationship, Drug; D008453:Maytansine / Q000032:analysis* / Q000494:pharmacology; D010407:Penicillium / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D008453:Maytansine