A new antibiotic, antimycin Ag, produced by Streptomyces sp. K01-0031.
A new antimycin group antibiotic, antimycin A9, was isolated from a cultured broth of Streptomyces sp. K01-0031 together with antimycins A3a, A3b, A4, and A7, and flazin methyl ester. Antimycin A9 is the first antimycin having an aromatic 8-acyl residue. It showed potent nematocidal and insecticidal activities against Caenorhabditis elegans and Artemia salina, respectively. It inhibited bovine heart NADH oxidase at nanomolar level like other known antimycins.
Shiomi
Kazuro
K
School of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo 108-8641, Japan. shiomik@pharm.kitasato-u.ac.jp
Hatae
Kenji
K
Hatano
Hiroko
H
Matsumoto
Atsuko
A
Takahashi
Yoko
Y
Jiang
Cheng-Lin
CL
Tomoda
Hiroshi
H
Kobayashi
Susumu
S
Tanaka
Haruo
H
Omura
Satoshi
S
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000968:Antimycin A / Q000031:analogs & derivatives* / Q000302:isolation & purification* / Q000494:pharmacology; D000969:Antinematodal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects; D017173:Caenorhabditis elegans / Q000187:drug effects; D002417:Cattle; D008826:Microbial Sensitivity Tests; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors; D013302:Streptomyces; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000969:Antinematodal Agents; D009097:Multienzyme Complexes; C499974:antimycin A9; D000968:Antimycin A; C023107:NADH oxidase; D009247:NADH, NADPH Oxidoreductases