Ketogenic diet prevents clusterin accumulation induced by kainic acid in the hippocampus of male ICR mice.
We investigated the effect of ketogenic diet (KD) on clusterin accumulation in the kainic acid (KA)-induced seizure model. Two days after KA administration, strong clusterin-like immunoreactivity (IR) was detected in the hippocampus in the normal diet (ND)-fed mice. But in the KD-fed mice, few clusterin-like IR was detected. These results indicate that KD has neuroprotective effects throughout diminishing nuclear clusterin accumulation that is involved in caspase-3 independent cell death mechanism.
Noh
Hae Sook
HS
Department of Anatomy and Neurobiology, Institute of Health Science, College of Medicine, Gyeongsang National University, Chinju, Kyungnam 660-751, South Korea.
Kim
Dong Wook
DW
Kang
Sang Soo
SS
Cho
Gyeong Jae
GJ
Choi
Wan Sung
WS
D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D016923:Cell Death / Q000502:physiology; D051152:Clusterin; D004040:Dietary Carbohydrates / Q000378:metabolism; D004041:Dietary Fats / Q000378:metabolism; D004195:Disease Models, Animal; D006023:Glycoproteins / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism*; D007608:Kainic Acid; D007657:Ketone Bodies / Q000378:metabolism; D007662:Ketosis / Q000378:metabolism*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D018832:Molecular Chaperones / Q000378:metabolism*; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism*
C495243:Clu protein, mouse; D051152:Clusterin; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D006023:Glycoproteins; D007657:Ketone Bodies; D018832:Molecular Chaperones; D007608:Kainic Acid