NAADP: a new second messenger comes of age.
Nicotinic acid adenine dinucleotide phosphate (NAADP) is one of the most potent stimulators of intracellular Ca(2+) mobilization in a variety of cell types. Its role in physiological processes is increasingly demonstrated by NAADP increases following cellular stimulation. As a second messenger NAADP shows unique features such as the ability to mobilize Ca(2+) from stores that are physically distinct from those connected to the Ca(2+) channels located in the endoplasmic reticulum, namely, the inositol-1,4,5-trisphosphate and the cyclic-ADP-ribose/ ryanodine receptors. Furthermore, the NAADP-induced self-inactivation mechanism is suggestive of an irreversible binding of NAADP to its putative receptor.
Santella
Luigia
L
Laboratory of Cell Signaling, Stazione Zoologica A. Dohrn, Villa Comunale I-80121, Napoli, Italy.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009249:NADP / Q000031:analogs & derivatives* / Q000737:chemistry; D009865:Oocytes / Q000378:metabolism; D009991:Oscillometry; D015290:Second Messenger Systems; D015398:Signal Transduction; D013215:Starfish; D013997:Time Factors
D009249:NADP; C024376:NAADP; D002118:Calcium