[Copaiba oil effect on aminotransferases of rats with hepatic ischemia and reperfusion with and without ischemic preconditioning].
OBJECTIVE
To study the copaiba oil effect in rats' aminotrasnferases submitted to hepatic ischemic and reperfusion with and without preconditioning.


METHODS
24 male and adults rats (Rattus norvegicus albinus, Wistar) were distributed into six groups: Standard Group (SG); Copaiba Group (CG), Ischemic-reperfusion Group (IRG), Ischemic-reperfusion + Copaiba Group (IRCG), Ischemic Preconditioning Group (IPCG) and Ischemic Preconditioning + Copaiba Group (IPCCG). The animals of CG, IRCG and IPCCG received copaiba oil, 0.63 ml/kg/day by gavage, during 7 days. It was realized total hepatic ischemic by 30 minutes and, in animals subbimited to ischemic preconditioning, it was realized 10 minutes of ischemia, following by 5 minutes of reperfusion and other ischemia by 30 minutes. All animals were subbmited to 24 hours of reperfusion. To realize surgery procedure, animals were anesthezied through ethilic eter breathing. On first post-operating day, blood was collected to dose aminotransferases.


RESULTS
It was not observe alterations in AST level in animals which received copaiba oil. There was no statistic difference between IRCG and IRG ALT levels, however, this enzyme was increased in IPCCG when compared with IPCG.


CONCLUSIONS
Copaiba oil did not change AST levels in groups studied. Analysing ALT, this oil did not change its values in animals were realized just hepatic ischemic-reperfusion, however, it had levels increase in IPCCG when compared to IPCG Between IRCG and IPCCG, ALT levels were not statistical different.
de Araújo Júnior
Francisco Alves
FA
Laboratório de Cirurgia Experimental (LCE) da Universidade do Estado do Pará (UEPA) Graduandos do Curso de Medicina da Universidade do Estado do Pará (UEPA). faraujojr@yahoo.com.br
Braz
Marcelle Nobre
MN
da Rocha Neto
Ozéas Galeno
OG
Costa
Felipe D'Almeida
FD
Brito
Marcus Vinicius Henriques
MV
D000818:Animals; D001453:Balsams / Q000494:pharmacology*; D019194:Ischemic Preconditioning; D008099:Liver / Q000098:blood supply* / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000201:enzymology*; D000637:Transaminases / Q000187:drug effects*
D001453:Balsams; C114971:copaiba balsam; D000637:Transaminases