title: Preparation and evaluation of a doubly tethered chiral stationary phase based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid.
abstract: A new doubly tethered chiral stationary phase (CSP) was prepared to enhance CSP stability as well as to take advantage of the tertiary amide linkage by bonding (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid to bis(3-aminopropyl)silica gel. The new CSP was quite effective in the resolution of alpha-amino acids, beta-amino acids, amino alcohols, and amines and the chromatographic resolution behaviors of the new CSP were exactly consistent with those of the corresponding singly tethered CSP containing N-CH3 tertiary amide linkage. Direct comparison between the stabilities of the new CSP and the corresponding singly tethered CSP containing N-CH3 tertiary amide linkage under harsh chromatographic conditions reveals that the new CSP is more stable than the latter.
authors.affiliation: Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Pusan 609-735, Republic of Korea. mhhyun@pusan.ac.kr
authors.forename: Myung Ho
authors.initials: MH
authors.lastname: Hyun
authors.forename: Do Hun
authors.initials: DH
authors.lastname: Kim
authors.forename: Yoon Jae
authors.initials: YJ
authors.lastname: Cho
authors.forename: Jong Sung
authors.initials: JS
authors.lastname: Jin