title: [Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome. Contribution of two new cases].
abstract: The autoimmune hepatitis (AIH)-primary biliary cirrhosis (PBC) overlap syndrome is characterized for clinical, biochemical, immunological, and histological features overlapping those of AIH and PBC, whose pathogenesis and more appropriate treatment are unknown at present. We describe two new patients of this entity, which made debut with cholestasic acute hepatitis accompanied of hypergammaglobulinemia. In the first patient was demonstrated the presence of AMA, ASMA, and anti-LKM1 autoantibodies; and ANA in the second one. The histological findings showed changes suggestive of AIH and PBC. After the start of immunosuppressive treatment, associated to ursodeoxycholic acid in one patient, a successful outcome was observed.
authors.affiliation: Servicio de Medicina Interna, Complexo Hospitalario Universitario Xeral-Cíes, Vigo. fjfer@mundo-r.com
authors.forename: F J
authors.initials: FJ
authors.lastname: Fernández Fernández
authors.forename: J
authors.initials: J
authors.lastname: de la Fuente Aguado
authors.forename: S
authors.initials: S
authors.lastname: Pérez Fernández
authors.forename: B
authors.initials: B
authors.lastname: Sopeña Pérez-Argüelles
authors.forename: A
authors.initials: A
authors.lastname: Nodar Germiñas
authors.forename: M
authors.initials: M
authors.lastname: Butrón Vila
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D019693:Hepatitis, Autoimmune / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000175:diagnosis