Immunization with recombinant surface antigen P50 of Babesia gibsoni expressed in insect cells induced parasite growth inhibition in dogs.
This is a report of a vaccine trial directed against Babesia gibsoni infection in dogs with the use of the recombinant antigen P50. Dogs immunized with P50 showed partial protection manifested as a significantly low level of parasitemia. The results indicated that P50 is a primary vaccine candidate molecule against canine B. gibsoni infection.
Fukumoto
Shinya
S
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
Tamaki
Yoh
Y
Shirafuji
Hiroaki
H
Harakawa
Shinji
S
Suzuki
Hiroshi
H
Xuan
Xuenan
X
D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology* / Q000627:therapeutic use; D000954:Antigens, Surface / Q000276:immunology; D001403:Babesia / Q000276:immunology; D001404:Babesiosis / Q000276:immunology / Q000517:prevention & control* / Q000662:veterinary; D015153:Blotting, Western / Q000379:methods; D002478:Cells, Cultured; D004283:Dog Diseases / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D007114:Immunization / Q000379:methods*; D007313:Insecta / Q000166:cytology / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000276:immunology / Q000627:therapeutic use; D013997:Time Factors
D000953:Antigens, Protozoan; D000954:Antigens, Surface; D011993:Recombinant Fusion Proteins