title: Novel approach to nucleoside-5'-(1-hydroxymethylene-1, 1-bisphosphonates): synthesis of new AZT analogues.
abstract: An efficient synthetic method of nucleoside-5'-(1-hydroxymethylene-1,1-bisphosphonates) is reported here. The procedure was optimized with 3'-protected thymidine and then applied to synthesis of new AZT analogues.
authors.affiliation: Laboratoire de Chimie Structurale Biomoléculaire (UMR 7033-CNRS), UFR SMBH, Université Paris 13, Bobigny Cedex, France.
authors.forename: Evelyne
authors.initials: E
authors.lastname: Migianu
authors.forename: Maëlle
authors.initials: M
authors.lastname: Monteil
authors.forename: Pascale
authors.initials: P
authors.lastname: Even
authors.forename: Marc
authors.initials: M
authors.lastname: Lecouvey
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis; D015394:Molecular Structure; D015215:Zidovudine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000998:Antiviral Agents; D015215:Zidovudine