title: N-Hydroxy sulfonimidamides as new nitroxyl (HNO) donors.
abstract: Chlorination and condensation of simple sulfinamides with O-benzyl and O-tert-butyl dimethyl siloxy hydroxylamine gives O-protected N-hydroxy sulfonimidamides. Deprotection of these compounds produces the corresponding sulfinamide and nitrous oxide, which provides evidence for the intermediacy of nitroxyl (HNO) and identifies these compounds as new potential HNO donors.
authors.affiliation: Department of Chemistry, College of St. Mary, 1901 S. 72nd Street, Omaha, NE 68124-2377, USA.
authors.forename: Richard L
authors.initials: RL
authors.lastname: Pennington
authors.forename: Xin
authors.initials: X
authors.lastname: Sha
authors.forename: S Bruce
authors.initials: SB
authors.lastname: King
mesh_terms: D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D007202:Indicators and Reagents; D008958:Models, Molecular; D015394:Molecular Structure; D020030:Nitric Oxide Donors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D019001:Nitric Oxide Synthase / Q000378:metabolism; D009609:Nitrous Oxide / Q000378:metabolism; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D007202:Indicators and Reagents; D020030:Nitric Oxide Donors; D013449:Sulfonamides; D003577:Cytochrome P-450 Enzyme System; D019001:Nitric Oxide Synthase; D009609:Nitrous Oxide