title: Homeostatic niche specification among naïve and activated B cells: a growing role for the BLyS family of receptors and ligands.
abstract: B lymphocyte homeostasis encompasses the establishment and maintenance of independently regulated niches, within which cells compete for viability promoting resources. The BLyS/BLyS receptor family controls the size and composition of these niches, by governing the selection and survival of most peripheral B cells. Moreover, different receptor-ligand sets from this family dominate the regulation of various B cell subsets. These observations suggest a model whereby the regulation of BLyS receptors by differentiative and stimulatory cues yield characteristic BLyS receptor signatures, thus specifying homeostatic niche and competitive advantage.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 284 John Morgan Building, 36th And Hamilton Walk, Philadelphia, PA 19104-8062, USA.
authors.forename: Jenni E
authors.initials: JE
authors.lastname: Crowley
authors.forename: Laura S
authors.initials: LS
authors.lastname: Treml
authors.forename: Jason E
authors.initials: JE
authors.lastname: Stadanlick
authors.forename: Erica
authors.initials: E
authors.lastname: Carpenter
authors.forename: Michael P
authors.initials: MP
authors.lastname: Cancro
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D008024:Ligands; D008213:Lymphocyte Activation; D051379:Mice; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism*
chemical_list: C120197:BLyS receptor; D008024:Ligands; D018124:Receptors, Tumor Necrosis Factor