Iron and atherosclerosis.
Traditional risk factors fail to account for all deaths from coronary artery disease (CAD). Iron can inflict oxidative injury on components of the blood and arterial wall to incite the atherosclerotic process. Medical evidence suggests a role of elevated body iron stores as a risk factor for the development of atherosclerosis. Results of a clinical trial to determine the benefits of reducing body iron stores on cardiovascular mortality are pending.
Qayyum
Rehan
R
Pat and Jim Calhoun Cardiology Center, University of Connecticut Health Center, 263 Farmington Avenue Farmington, CT 06030-2202, USA.
Schulman
Peter
P
D001161:Arteriosclerosis / Q000209:etiology*; D015444:Exercise / Q000502:physiology; D006470:Hemorrhage / Q000473:pathology; D006801:Humans; D007501:Iron / Q000378:metabolism* / Q000502:physiology; D008077:Lipoproteins, LDL / Q000378:metabolism; D010084:Oxidation-Reduction; D012307:Risk Factors
D008077:Lipoproteins, LDL; D007501:Iron