YM-216391, a novel cytotoxic cyclic peptide from Streptomyces nobilis. II. Physico-chemical properties and structure elucidation.
YM-216391, a novel cytotoxic cyclic peptide, has been isolated from the cultured mycelium of Streptomyces nobilis JCM 4274. The planar structure of YM-216391 was assigned on the basis of 1D and 2D NMR spectroscopic techniques. The absolute configuration of the amino acid residues in YM-216391 was determined by Marfey's analysis and chiral HPLC analysis of its acid hydrolysate.
Sohda
Kin-ya
KY
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Itabashi-ku, Tokyo 174-8511, Japan. souda@yamanouchi.co.jp
Hiramoto
Masashi
M
Suzumura
Ken-ichi
K
Takebayashi
Yukihiro
Y
Suzuki
Ken-ichi
K
Tanaka
Akihiro
A
D000970:Antineoplastic Agents / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010080:Oxazoles / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification; D010456:Peptides, Cyclic / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification; D013302:Streptomyces
D000970:Antineoplastic Agents; D010080:Oxazoles; D010456:Peptides, Cyclic; C499972:YM 216391