title: Expedient synthesis and design strategies for new peptoid construction.
abstract: [reaction: see text] A range of peptoids can be prepared efficiently using microwave-assisted solid-phase chemistry in a commercial reactor. This method is most effective for the installation of electronically deactivated benzylic amines. The systematic incorporation of these amines into peptoids can deliver oligomers capable of displaying unique and stable structural motifs-microwave-assisted solid-phase synthesis will enable their future study and application.
authors.affiliation: Department of Chemistry, 1101 University Avenue, University of Wisconsin, Madison, Wisconsin 53706-1322, USA.
authors.forename: Benjamin C
authors.initials: BC
authors.lastname: Gorske
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Jewell
authors.forename: Emily J
authors.initials: EJ
authors.lastname: Guerard
authors.forename: Helen E
authors.initials: HE
authors.lastname: Blackwell
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000295:instrumentation* / Q000379:methods*; D008872:Microwaves; D015394:Molecular Structure; D034444:Peptoids / Q000138:chemical synthesis*
chemical_list: D034444:Peptoids