title: Systemic aspergillosis with predominant genitourinary manifestations in an immunocompetent man: what we can learn from a disastrous follow-up.
abstract: Prostatic aspergillosis is a rare finding with only ten cases reported previously. We report the first case of systemic aspergillosis predominantly presenting with prostatic involvement and, clinically, with urinary retention in an immunocompetent host. Routine transurethral resection was performed due to benign prostatic hyperplasia with subvesical obstruction. Concomitant prostatic aspergillosis was diagnosed without signs of systemic infection. In the clinical follow-up systemic aspergillosis became rapidly progressive requiring complex surgical interventions and long-term antifungal therapy. The current literature is reviewed, and diagnostic and management options are discussed.
authors.affiliation: Dept. for Urology and Pediatric Urology, University Hospital Giessen, Rudolf-Buchheim-Str. 7, 35385, Giessen, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Ludwig
authors.forename: H
authors.initials: H
authors.lastname: Schneider
authors.forename: J
authors.initials: J
authors.lastname: Lohmeyer
authors.forename: L
authors.initials: L
authors.lastname: Ermert
authors.forename: A
authors.initials: A
authors.lastname: Sziegoleit
authors.forename: D
authors.initials: D
authors.lastname: Lommel
authors.forename: W
authors.initials: W
authors.lastname: Weidner
mesh_terms: D000038:Abscess / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology*; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis* / Q000188:drug therapy; D000077336:Caspofungin; D054714:Echinocandins; D006801:Humans; D007674:Kidney Diseases / Q000382:microbiology*; D055666:Lipopeptides; D008172:Lung Diseases, Fungal / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000627:therapeutic use; D011469:Prostatic Diseases / Q000382:microbiology*; D011743:Pyrimidines / Q000627:therapeutic use; D012187:Retroperitoneal Space / Q000382:microbiology; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; D011743:Pyrimidines; D014230:Triazoles; D000077336:Caspofungin; D065819:Voriconazole