title: Pour-on formulation of eprinomectin for cattle: fecal elimination profile and effects on the development of the dung-inhabiting Diptera Neomyia cornicina (L.) (Muscidae).
abstract: The plasma and fecal concentrations of eprinomectin were determined in cattle following topical administration at a dose rate of 0.5 mg kg(-1). The maximum plasma concentrations of 12.24 ng ml(-1) occurred 2 d after administration, and eprinomectin remained detectable in plasma 29 d after administration (0.10 ng ml(-1)). The maximum dung concentration of 350 ng g(-1) was observed 3 d after administration and thereafter for at least 29 d (4 ng g(-1)). The amount of drug recovered in dung during this period was 20.50%+/-4.31% of the total administered dose. The effects of eprinomectin against the nontarget dung-feeding Diptera Neomyia cornicina was assessed under laboratory conditions. Feces voided by cattle treated with eprinomectin were associated with high larval mortality during the first 12 d after treatment, with null emergence until day 7. The no-observed-effect concentration for N. cornicina was estimated to be close to 7+/-5 ng g(-1).
authors.affiliation: UMR 5175 CEFE (Centre d'Ecologie Fonctionnelle et Evolutive), Laboratoire de Zoogéographie, Université Paul Valéry-Montpellier III, Route de Mende, F-34199 Montpellier Cedex 5, France. jean-pierre.lumaret@univ-montp3.fr
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Lumaret
authors.forename: Faiek
authors.initials: F
authors.lastname: Errouissi
authors.forename: Pierre
authors.initials: P
authors.lastname: Galtier
authors.forename: Michel
authors.initials: M
authors.lastname: Alvinerie
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D001681:Biological Assay; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy / Q000378:metabolism*; D004175:Diptera / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000737:chemistry*; D007300:Insect Control; D007559:Ivermectin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics*; D007814:Larva / Q000187:drug effects; D009026:Mortality; D019055:No-Observed-Adverse-Effect Level; D013997:Time Factors
chemical_list: D000871:Anthelmintics; D007559:Ivermectin; C101434:eprinomectin