title: Encephalopathy and peripheral neuropathy following diethylene glycol ingestion.
abstract: The authors report a 24-year-old man who developed encephalopathy and rapid quadriplegia following ingestion of a solution containing diethylene glycol (DEG). As quadriparesis evolved, motor response amplitudes were markedly reduced with preserved conduction velocities. Studies during clinical recovery revealed marked motor conduction velocity slowing and prolonged distal latencies. These data indicate that DEG intoxication may cause a primary acute axonal sensorimotor polyneuropathy with demyelinating physiology during recovery.
authors.affiliation: Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce St., 3 West Gates, Philadelphia, PA 19104-4283, USA. hasbani2001@yahoo.com
authors.forename: M J
authors.initials: MJ
authors.lastname: Hasbani
authors.forename: L H
authors.initials: LH
authors.lastname: Sansing
authors.forename: J
authors.initials: J
authors.lastname: Perrone
authors.forename: A K
authors.initials: AK
authors.lastname: Asbury
authors.forename: S J
authors.initials: SJ
authors.lastname: Bird
mesh_terms: D000328:Adult; D001928:Brain Diseases, Metabolic / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D003389:Cranial Nerve Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology; D003391:Cranial Nerves / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D004576:Electromyography; D005026:Ethylene Glycols / Q000506:poisoning*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000473:pathology; D009431:Neural Conduction / Q000187:drug effects / Q000502:physiology; D010525:Peripheral Nerves / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D011782:Quadriplegia / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology; D020127:Recovery of Function / Q000502:physiology; D012021:Reflex, Abnormal / Q000187:drug effects / Q000502:physiology; D014855:Wallerian Degeneration / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology
chemical_list: D005026:Ethylene Glycols; C013484:diethylene glycol