Effect of leukocyte-depleted blood cardioplegia on the early outcome in patients with preserved left ventricular function undergoing surgical revascularisation.
BACKGROUND
It has been shown that leukocytes play one of the key roles in the myocardial reperfusion injury.


OBJECTIVE
To examine the effects of cardiac protection with leukocyte-depleted blood cardioplegia on the early outcome of patients with preserved left ventricular function who undergo surgical revascularisation.


METHODS
The study group consisted of 58 patients with coronary artery disease (CAD) undergoing coronary artery bypass grafting (CABG) who were randomised to receive leukocyte-depleted blood cardioplegia (leukocyte filter Pall BC1B) (group A, n=29) or to receive standard blood cardioplegia (group B, n=29). Peri-operative mortality and morbidity as well as haemodynamical and biochemical parameters were compared between these two groups.


RESULTS
No early death occurred. There were no statistical differences in clinical data between the groups. Only cardiac index measured 24 hours after declamping of aorta was significantly higher in group A than in group B (3.6+/-0.6 l/min/m(2) vs 2.95+/-0.45 l/min/m(2), p<0.05). Group B showed significant higher release of creatine kinase (CK) 6 and 12 hours, and CK-MB 6, 12, and 24 hours after unclumping the aorta whereas troponin I level was similar in both groups.


CONCLUSIONS
The use of leukocyte-depleted blood cardioplegia during elective CABG did not improve the early outcome.
Czech
Bronisław
B
Department of Cardiac Surgery, Białystok, Poland.
Frank
Marek
M
Kucewicz
Ewa
E
Szapiel
Grzegorz
G
Jackowski
Ryszard
R
Gabrylewska
Alicja
A
Busłowska
Jolanta
J
D000368:Aged; D002314:Cardioplegic Solutions / Q000008:administration & dosage; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000601:surgery*; D004311:Double-Blind Method; D005260:Female; D006324:Heart Arrest, Induced / Q000009:adverse effects* / Q000379:methods*; D006801:Humans; D047589:Leukocyte Reduction Procedures / Q000379:methods; D008297:Male; D008875:Middle Aged; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology* / Q000517:prevention & control*; D016896:Treatment Outcome
D002314:Cardioplegic Solutions