Analysis of the Par2 modifier of pulmonary adenoma formation in mice.
Inbred strains of mouse show various susceptibilities to spontaneous and chemical-induced lung tumorigenesis. Genetic analyses have revealed that lung tumor susceptibilities of inbred mouse strains are governed by quantitative trait loci (QLTs) located on multiple chromosomes. A major lung tumor resistance QLT, designated pulmonary adenoma resistance 2 (Par2), was mapped to the mouse chromosome 18 independently by several groups and accounted for up to 60% phenotype variance between susceptible A/J and more resistant BALB/c strains. The authors recently conducted studies to positionally clone the Par2 gene. This review summarizes the effort and progress towards the identification of Par2 candidates.
Wang
Min
M
Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Wang
Yian
Y
You
Ming
M
Devereux
Theodora R
TR
D000236:Adenoma / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D002874:Chromosome Mapping; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D008175:Lung Neoplasms / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D040641:Quantitative Trait Loci