Six-helix bundles designed from DNA.
We present a designed cyclic DNA motif that consists of six DNA double helices that are connected to each other at two crossover sites. DNA double helices with 10.5 nucleotide pairs per turn facilitate the programming of DNA double crossover molecules to form hexagonally symmetric arrangements when the crossover points are separated by seven or fourteen nucleotide pairs. We demonstrate by atomic force microscopy well-formed arrays of hexagonal six-helix bundle motifs both in 1D and in 2D.
Mathieu
Frederick
F
Department of Chemistry, New York University, New York, New York 10003, USA.
Liao
Shiping
S
Kopatsch
Jens
J
Wang
Tong
T
Mao
Chengde
C
Seeman
Nadrian C
NC
D001483:Base Sequence; D003434:Crossing Over, Genetic; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D018625:Microscopy, Atomic Force; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation
D004247:DNA