Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study.
Case-cohort analyses were performed on meat and fish consumption in relation to K-ras mutations in 448 colon and 160 rectal cancers that occurred during 7.3 years of follow-up, excluding the first 2.3 years, and 2948 subcohort members of The Netherlands Cohort Study on diet and cancer. Adjusted incidence rate ratios and 95% confidence intervals were computed for colon and rectal cancer and for K-ras mutation status subgroups. Total fresh meat, most types of fresh meat and fish were not associated with colon or rectal cancer, neither overall nor with K-ras mutation status. However, several weak associations were observed for tumours with a wild-type K-ras, including beef and colon tumours, and an inverse association for pork with colon and rectal tumours; for meat products, an increased association was observed with wild-type K-ras tumours in the colon and possibly with G>A transitions in rectal tumours.
Brink
M
M
Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Department of Epidemiology, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands.
Weijenberg
M P
MP
de Goeij
A F P M
AF
Roemen
G M J M
GM
Lentjes
M H F M
MH
de Bruïne
A P
AP
Goldbohm
R A
RA
van den Brandt
P A
PA
D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D003110:Colonic Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics* / Q000517:prevention & control; D004252:DNA Mutational Analysis; D004032:Diet; D005260:Female; D011905:Genes, ras; D006801:Humans; D008297:Male; D008460:Meat; D008461:Meat Products; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D012004:Rectal Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics* / Q000517:prevention & control; D012307:Risk Factors; D017747:Seafood