Serotonin modulates responses to species-specific vocalizations in the inferior colliculus.
Neuromodulators such as serotonin are capable of altering the neural processing of stimuli across many sensory modalities. In the inferior colliculus, a major midbrain auditory gateway, serotonin alters the way that individual neurons respond to simple tone bursts and linear frequency modulated sweeps. The effects of serotonin are complex, and vary among neurons. How serotonin transforms the responses to spectrotemporally complex sounds of the type normally heard in natural settings has been poorly examined. To explore this issue further, the effects of iontophoretically applied serotonin on the responses of individual inferior colliculus neurons to a variety of recorded species-specific vocalizations were examined. These experiments were performed in the Mexican free-tailed bat, a species that uses a rich repertoire of vocalizations for the purposes of communication as well as echolocation. Serotonin frequently changed the number of recorded calls that were capable of evoking a response from individual neurons, sometimes increasing (15% of serotonin-responsive neurons), but usually decreasing (62% of serotonin-responsive neurons), this number. A functional consequence of these serotonin-evoked changes would be to change the population response to species-specific vocalizations.
Hurley
Laura M
LM
Jordan Hall/ Biology Department, Indiana University, 1001 East Third Street, Bloomington, IN 47405, USA. lhurley@bio.indiana.edu
Pollak
George D
GD
D000161:Acoustic Stimulation / Q000379:methods; D000200:Action Potentials / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D000818:Animals; D001522:Behavior, Animal; D002452:Cell Count; D002685:Chiroptera; D004455:Echolocation / Q000187:drug effects* / Q000502:physiology; D004566:Electrodes; D007245:Inferior Colliculi / Q000166:cytology* / Q000502:physiology; D007478:Iontophoresis / Q000379:methods; D009474:Neurons / Q000145:classification / Q000187:drug effects* / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology*; D013045:Species Specificity; D014828:Vocalization, Animal / Q000187:drug effects* / Q000502:physiology
D012701:Serotonin