title: Trypanosoma avium incidence, pathogenicity and response to melarsomine in falcons from Kuwait.
abstract: Epidemiological and clinical studies on Trypanosoma avium are lacking in the Middle East. The aims of this study were to determine the T. avium incidence in falcons from Kuwait, report clinical signs and find an effective therapy. Blood smears from 921 diseased and 56 healthy falcons were examined between May 2003 and April 2004. 12 birds 11.3%) were found infected by T. avium and ten of these were treated with melarsomine (Cymelarsan) at a dosage of 0.25 mg/kg intramuscularly for four days. All affected birds presented clinical signs, including incapacity of flying high, poor appetite, lethargy, loosing weight, weakness, dyspnoea and death. Signs disappeared within 1-7 days after administration of melarsomine. Trypomastigotes were not detected in blood smears made 1-7 days after the end of therapy. This study suggests that T. avium induces disease in falcons and that melarsomine can be an effective therapy eliminating both clinical signs and circulating trypomastigotes.
authors.affiliation: International Veterinary Hospital, PO Box 9275, 61003 Ahmadi, Kuwait. wtarello@yahoo.it
authors.forename: W
authors.initials: W
authors.lastname: Tarello
mesh_terms: D000818:Animals; D001152:Arsenicals / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001715:Bird Diseases / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology; D046093:Falconiformes / Q000469:parasitology*; D005260:Female; D006790:Host-Parasite Interactions; D015994:Incidence; D007273:Injections, Intramuscular / Q000662:veterinary; D007730:Kuwait; D008297:Male; D016896:Treatment Outcome; D014227:Triazines / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D014344:Trypanocidal Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D014345:Trypanosoma / Q000187:drug effects / Q000472:pathogenicity*; D014352:Trypanosomiasis / Q000188:drug therapy / Q000453:epidemiology / Q000662:veterinary*
chemical_list: D001152:Arsenicals; D014227:Triazines; D014344:Trypanocidal Agents; C076253:melarsomine