[Quantitative evaluation of canine renal blood flow with contrast-enhanced ultrasound].
OBJECTIVE
To evaluate the accuracy of contrast-enhanced ultrasound (CEU) in renal blood flow quantification.


METHODS
Regional renal perfusion was quantified with CEU in 10 dogs at the baseline level and after treatment with 3 doses of dopamine (3, 8 and 16 mg.kg(-1).min(-1)), and renal arterial flow (RAF) was measured with ultrasonic flow probes deployed directly on the renal artery simultaneously. Normalized RAF was calculated as RAF divided by renal weight (ml.min(-1).g(-1)).


RESULTS
Compared with the baseline level, a progressive increase in RAF was induced by dopamine treatment at the doses of 3 and 8 mg.kg(-1).min(-1) (P<0.05), but at a higher dose of 16 mg.kg(-1).min(-1), the increment in RAF was reduced in comparison with that with the two lower doses (P<0.05). The same changes in cortical nutrient blood flow derived from CEU were observed. Significant positive correlation was found between normalized RAF and CEU-derived cortical nutrient blood flow (y=39.8x + 44.3, r=0.88, P<0.001).


CONCLUSIONS
CEU can be used to accurately quantify renal blood flow in dogs.
Xiao
Wen-Xing
WX
Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. xwx@fimmu.com
Bin
Jian-Ping
JP
Xie
Jin-Guo
JG
Liu
Jian
J
Cha
Dao-Gang
DG
Xu
Ding-Li
DL
D000818:Animals; D003287:Contrast Media; D004285:Dogs; D004298:Dopamine / Q000494:pharmacology; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D007668:Kidney / Q000000981:diagnostic imaging*; D012039:Regional Blood Flow; D012079:Renal Circulation / Q000502:physiology*; D014463:Ultrasonography
D003287:Contrast Media; D004298:Dopamine