title: [Physiological problems of biological evolution. "Errors" in the development of physiological functions].
abstract: During the evolution the physiological functions grow more perfect and complex. However, sometimes a developing function can show some evidence of regress and in certain cases can become the cause of dangerous diseases. The autoimmune diseases are among them. We conventionally call such cases the "error" of the evolution. In this work a negative role of leukocytes in the brain microcirculation is considered. With the help of experimental studies it was shown that leukocytes owing to their large volume (by a factor of 2-2.5 greater than the volume of an erythrocyte) slow down the capillary blood flow. As the result of the increasing tendency to adhesion, under the influence of hypoxia they make leukocyte conglomerates which cause the occlusion of venules and smallest veins of the brain. This is the reason for the known effect "no reflow" and results in an organism death.
authors.forename: K P
authors.initials: KP
authors.lastname: Ivanov
authors.forename: N N
authors.initials: NN
authors.lastname: Mel'nikova
mesh_terms: D000818:Animals; D005075:Biological Evolution; D001921:Brain / Q000098:blood supply / Q000503:physiopathology; D002448:Cell Adhesion / Q000276:immunology; D015687:Cell Hypoxia; D004730:Endothelium, Vascular / Q000503:physiopathology; D006801:Humans; D007962:Leukocytes / Q000502:physiology; D007964:Leukocytosis / Q000503:physiopathology; D008833:Microcirculation / Q000503:physiopathology; D010828:Physiology, Comparative