title: Synthesis of 3-arylpiperidines by a radical 1,4-aryl migration.
abstract: [reaction: see text] A route to 3-arylpiperidines, 3-arylpyridines, and 5-arylpiperidin-2-ones involving a radical 1,4-aryl migration has been explored. The sequence requires a xanthate addition to an N-allylarylsulfonamide, followed by acetylation and treatment with dilauroyl peroxide to give the 1,4-aryl transfer product, which upon acidic hydrolysis affords the desired piperidine derivative.
authors.affiliation: Laboratoire de Synthèse Organique, Département de Chimie, Ecole Polytechnique, Route de Saclay, 91128 Palaiseau Cedex, France.
authors.forename: Alexandru
authors.initials: A
authors.lastname: Gheorghe
authors.forename: Béatrice
authors.initials: B
authors.lastname: Quiclet-Sire
authors.forename: Xavier
authors.initials: X
authors.lastname: Vila
authors.forename: Samir Z
authors.initials: SZ
authors.lastname: Zard