[Cefepime-induced encephalopathy: clinical and electroencephalographic features in seven patients].
Cefepime, a fourth-generation cephalosporin, with large antibacterial spectrum, is a commonly used antibiotic for the treatment of serious hospital infections. Its security report is considered favourable. Recently, many cases of a severe and reversible cefepime-induced encephalopathy were described. In this paper, we report seven patients with reversible cefepime-induced encephalopathy, with a peculiar EEG pattern, characterized by semiperiodic diffuse triphasic waves. We discuss the EEG abnormalities found and their association with nonconvulsive status epilepticus.
Bragatti
José Augusto
JA
Unidade de Eletroencefalografia, Hospital de Clínicas, Porto Alegre, RS, Brazil. jabragatti@terra.com.br
Rossato
Roberto
R
Ziomkowski
Sofia
S
Kliemann
Frederico Arthur Dahne
FA
D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000077723:Cefepime; D002511:Cephalosporins / Q000009:adverse effects*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020258:Neurotoxicity Syndromes / Q000209:etiology*
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000077723:Cefepime