title: Predictors of death on the waiting list for liver transplantation characterized by a long waiting time.
abstract: The number of patients dying while on the liver transplantation (LT) waiting list (WL) has continued to increase in recent years as a result of severe shortage of organs. Therefore, it is important to evaluate the existing models that predict death on the WL and to determine the independent predictors of death. The study cohort comprised 152 adult patients listed for LT in our centre over a period of 2 years (January 2001 to January 2003). The 12-month survival rate has been calculated by Kaplan-Meier method. The survival analysis performed by Cox proportional hazard model has evaluated the three parameters which compose the model for end-stage liver disease (MELD) score. Forty-four patients (28.9%) died while listed for LT. The survival rate was 92% at 3 months, 80% at 6 months and 69% at 12 months. Median survival was not reached. MELD score was found to be an excellent predictor of death at 12 months on our WL--c-statistic (area under curve) 0.84. In our survival analysis, only international normalized (prothrombin) ratio (INR) and serum creatinine were identified as an independent predictors of death (P < 0.0001). A new simplified version of the MELD score, which does not include serum bilirubin, is proposed and its c-statistic as predictor for death on the WL at 12 months is 0.86, as good as the original MELD score, when evaluated on our list. There is a fourfold increase in mortality on our WL for LT between 3 and 12 months after the inclusion. A simplified version of the MELD score, using only serum creatinine and INR might be taken into account when predicting 12 months mortality on WL with longer waiting time, but it has to be confirmed by other prospective studies.
authors.affiliation: Department of Hepatology, Centre of Gastroenterology and Hepatology, Fundeni Clinical Institute, Bucharest, Romania. drgheorghe@xnet.ro
authors.forename: L
authors.initials: L
authors.lastname: Gheorghe
authors.forename: I
authors.initials: I
authors.lastname: Popescu
authors.forename: R
authors.initials: R
authors.lastname: Iacob
authors.forename: S
authors.initials: S
authors.lastname: Iacob
authors.forename: C
authors.initials: C
authors.lastname: Gheorghe
mesh_terms: D000328:Adult; D001663:Bilirubin / Q000097:blood; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D019934:International Normalized Ratio; D017093:Liver Failure / Q000097:blood / Q000401:mortality* / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012307:Risk Factors; D012383:Romania / Q000453:epidemiology; D016019:Survival Analysis; D013997:Time Factors; D009927:Tissue and Organ Procurement; D014850:Waiting Lists
chemical_list: D003404:Creatinine; D001663:Bilirubin