[The clinical significance of interferon-gamma and its receptor in patients with schistosomiasis].
OBJECTIVE
To study the expression of interferon-gamma (IFN-gamma) and type I interferon-y receptor (IFN-gammaRI) in the chronic and advanced patients of schistosomiasis japonica, and to discuss its clinical relationship with hepatic fibrosis. Methods IFN-yR1 in the peripheral blood lymphocytes was detected by ELISA, and the hyaluronic acid (HA) , collagen type IV (C-IV), procollagen type III (PC III), laminin (LN) were detected by radio-immunoassay (RIA) in schistosomiasis patients. The level of IFN-y, IFN-gammaR1 and serum markers of hepatic fibrosis were observed, and the relationship with each other was analyzed by statistical method.


RESULTS
There was no difference in the expression of IFN-gamma and IFN-gammaR1 between the patients with chronic schistosomiasis and the normal group (P > 0. 05 ), the IFN-gammaR1 in advanced cases without splenectomy was low (P <0. 05) , but IFN-y was high (P < 0. 01). The two indicators in the advanced schistosomiasis patients with splenectomy returned to normal. There was no corresponding relationship between the two indicators and HA, C-IV, PC III, LN with a r value of 0. 19, 0.20, 0. 14, and 0.21 respectively.


CONCLUSIONS
There is a corresponding relationship between IFN-gamma and IFN-gammaR1; the expression of IFN-gammaR1 is related to the course of schistosomiasis, and the relationship with hepatic fibrosis needs further study.
Shao
Ping-yang
PY
The First Hospital of Jiaxing, Jiaxing 314000, China.
Cai
Wei-min
WM
Ding
Ren-ye
RY
Wu
Wen-lin
WL
Huang
Yu-ying
YY
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D024061:Collagen Type III / Q000097:blood; D024141:Collagen Type IV / Q000097:blood; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D007371:Interferon-gamma / Q000097:blood*; D007797:Laminin / Q000097:blood; D008103:Liver Cirrhosis / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D017471:Receptors, Interferon / Q000097:blood*; D012554:Schistosomiasis japonica / Q000097:blood* / Q000276:immunology; D000096743:Interferon gamma Receptor
D024061:Collagen Type III; D024141:Collagen Type IV; D006820:Hyaluronic Acid; D007371:Interferon-gamma; D007797:Laminin; D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor