Live birth of healthy triplets after in vitro fertilization and embryo transfer in an acromegalic woman with elevated growth hormone.
OBJECTIVE
To report a case of successful triplet pregnancy in an acromegaly patient with IVF and embryo transfer.


METHODS
Case report.


METHODS
Tertiary center for assisted reproductive technologies.


METHODS
A 33-year-old woman with acromegaly and primary infertility.


METHODS
Controlled ovulation hyperstimulation and IVF/embryo-transfer treatment using gonadotropins.


METHODS
Uncomplicated pregnancy course and successful take-home triplet infant girls.


RESULTS
Successful ovarian stimulation and IVF is possible in acromegalic patients.


CONCLUSIONS
There may be an effect of elevated growth hormone resulting in increased ovarian response to gonadotropin, inducing hyperstimulation and high-order multiple pregnancies in these patients.
Esfandiari
Navid
N
Toronto Centre for Advanced Reproductive Technology, Toronto, Ontario, Canada.
Gotlieb
Lynda
L
Casper
Robert F
RF
D000172:Acromegaly / Q000097:blood* / Q000453:epidemiology; D000328:Adult; D015897:Comorbidity; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006062:Gonadotropins / Q000494:pharmacology / Q000627:therapeutic use; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000453:epidemiology / Q000628:therapy*; D010060:Ovulation / Q000187:drug effects / Q000502:physiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood* / Q000453:epidemiology; D011256:Pregnancy Outcome / Q000453:epidemiology*; D014310:Triplets / Q000502:physiology*
D006062:Gonadotropins; D019382:Human Growth Hormone