title: [The experimental study of garlicin in treating Pneumocystis carinii pneumonia in rats].
abstract: OBJECTIVE
  To assess the therapeutic effect of garlicin on Pneumocystis carinii pneumonia (PCP) of immunosuppressed rats.
  
  
  METHODS
  The Wistar rats were injected intramuscularly continually with dexamethasone for eight weeks to establish the rat model of PCP. The rats were treated with garlicin, meanwhile control groups without treatment and with SMZ-TMP treatment were established respectively in PCP model. The efficacy was evaluated based on the lung weight, lung/body weight ratio and mean cyst number per 100 fields in lung print smear.
  
  
  RESULTS
  The mean lung weight of the rats in garlicin is 1.73 +/- 0.17, lung/body weight ratio is 0.84 +/- 0.12, they are obvious lower than 2.31 +/- 0.35 and 1.25 +/- 0.35 of control (P <0.01). The numbers of cysts in lung print smear is reduced 62.9% compared with control. The results is similar to that with SMZ-TMP.
  
  
  CONCLUSIONS
  Garlicin shows an obvious therapeutic effect on Pneumocystis carinii pneumonia in rats with an efficacy similar to that with SMZ-TMP.
authors.affiliation: Department of Parasitology, Hebei North University, Zhangjiakou 075000, China.
authors.forename: Zhi-min
authors.initials: ZM
authors.lastname: Lu
authors.forename: Hong-wei
authors.initials: HW
authors.lastname: Tang
authors.forename: Zhen-ming
authors.initials: ZM
authors.lastname: Zhang
authors.forename: Jin-hua
authors.initials: JH
authors.lastname: Liu
authors.forename: Jin-shun
authors.initials: JS
authors.lastname: Zhang
authors.forename: Wei-zhen
authors.initials: WZ
authors.lastname: Zhang
mesh_terms: D000498:Allyl Compounds / Q000627:therapeutic use*; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D003907:Dexamethasone; D004220:Disulfides / Q000627:therapeutic use*; D005260:Female; D016720:Pneumocystis Infections / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000498:Allyl Compounds; D000935:Antifungal Agents; D004220:Disulfides; C028009:diallyl disulfide; D003907:Dexamethasone