[Analysis of related factors of nasosinusitis after radiotherapy for nasopharyngeal carcinoma].
OBJECTIVE
To study the incidence, clinical features and related factors of nasosinusitis after radiotherapy for nasopharyngeal carcinoma.


METHODS
Five hundred and thirteen patients with nasopharyngeal carcinoma were included in the study, to observe the clinical manifestation and image changes before and after radiotherapy. The incidence and influencing factors of nasosinusitis after radiotherapy were analyzed.


RESULTS
Among 513 patients, before radiotherapy, nasosinusitis was found in 51 patients (9.9%). After radiotherapy, another 401 nasosinusitis was found (401/462). The difference of incidence rate of nasosinusitis before and after radiotherapy was obvious (chi2 = 533.21, P < 0.01). The incidence rate of nasosinusitis in the end of radiotherapy, 3 months, 6 months, 12 months and 18 months after radiotherapy was 10.7% (43/401), 13.7% (55/401), 58.1% (233/401), 12.0% (48/401), 5.5% (22/401) respectively. The incidence rate of nasosinusitis after fractional radiotherapy and continuous radiotherapy was 35.7% (143/401), 64.3% (258/401) respectively.


CONCLUSIONS
The incidence rate of nasosinusitis after radiotherapy is very high. It is influenced by the dose of radiotherapy, but it has no relation with the extension of nasopharyngeal carcinoma.
Zhang
Xue-hui
XH
Department of Otorhinolaryngology Head and Neck Surgery, Second People's Hospital of Guangdong Province, Guangzhou 510310, China. chacha6hs@yahoo.com.cn
Huang
Jian-nan
JN
Fu
Xiang-jun
XJ
Zhan
Shun-tang
ST
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma; D015984:Causality; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D018787:Radiation Oncology; D011879:Radiotherapy Dosage; D012852:Sinusitis / Q000453:epidemiology*; D055815:Young Adult