title: Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study.
abstract: Case-cohort analyses were performed on meat and fish consumption in relation to K-ras mutations in 448 colon and 160 rectal cancers that occurred during 7.3 years of follow-up, excluding the first 2.3 years, and 2948 subcohort members of The Netherlands Cohort Study on diet and cancer. Adjusted incidence rate ratios and 95% confidence intervals were computed for colon and rectal cancer and for K-ras mutation status subgroups. Total fresh meat, most types of fresh meat and fish were not associated with colon or rectal cancer, neither overall nor with K-ras mutation status. However, several weak associations were observed for tumours with a wild-type K-ras, including beef and colon tumours, and an inverse association for pork with colon and rectal tumours; for meat products, an increased association was observed with wild-type K-ras tumours in the colon and possibly with G>A transitions in rectal tumours.
authors.affiliation: Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Department of Epidemiology, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Brink
authors.forename: M P
authors.initials: MP
authors.lastname: Weijenberg
authors.forename: A F P M
authors.initials: AF
authors.lastname: de Goeij
authors.forename: G M J M
authors.initials: GM
authors.lastname: Roemen
authors.forename: M H F M
authors.initials: MH
authors.lastname: Lentjes
authors.forename: A P
authors.initials: AP
authors.lastname: de Bruïne
authors.forename: R A
authors.initials: RA
authors.lastname: Goldbohm
authors.forename: P A
authors.initials: PA
authors.lastname: van den Brandt
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D003110:Colonic Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics* / Q000517:prevention & control; D004252:DNA Mutational Analysis; D004032:Diet; D005260:Female; D011905:Genes, ras; D006801:Humans; D008297:Male; D008460:Meat; D008461:Meat Products; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D012004:Rectal Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics* / Q000517:prevention & control; D012307:Risk Factors; D017747:Seafood