Diffuse optical tomography with spectral constraints and wavelength optimization.
We present an algorithm that explicitly utilizes the wavelength dependence of tissue optical properties for diffuse optical tomography. We have previously shown that the method gives superior separation of absorption and scattering. Here the technique is described and tested in detail, and optimum wavelength sets for a broad range of chromophore combinations are discovered and analyzed.
Corlu
Alper
A
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. corlua@dept.physics.upenn.edu
Choe
Regine
R
Durduran
Turgut
T
Lee
Kijoon
K
Schweiger
Martin
M
Arridge
Simon R
SR
Hillman
Elizabeth M C
EM
Yodh
Arjun G
AG
D000465:Algorithms; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D003198:Computer Simulation; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008954:Models, Biological; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity; D013053:Spectrophotometry / Q000379:methods*; D041622:Tomography, Optical / Q000379:methods*
D014408:Biomarkers, Tumor; D006454:Hemoglobins