title: [Establishment of a modified canine model of acute cardiac insufficiency].
abstract: OBJECTIVE
  To establish a canine model of acute cardiac insufficiency (ACI) by coronary artery occlusion and right ventricular pacing.
  
  
  METHODS
  Twelve dogs were subjected to rapid ventricular pacing after ligation of the left anterior descending coronary artery (LAD), to induce the cardiac output (CO) to reduce by 25%; and 50%; from the basal level. The arterial pressure (AP), arterial oxygen saturation (SaO(2)), mean right atrial pressure (mRAP), mean pulmonary capillary wedge pressure (mPCWP), and systemic vascular resistance (SVR) were measured in the dogs according to different CO conditions. Echocardiography was used to measure the cardiac size and left ventricular ejection fraction (LVEF).
  
  
  RESULTS
  CO was decreased by 25%; and 50%; steadily from the basal level after right ventricular pacing following ligation of the LAD. AP and SaO(2) decreased while mRAP, mPCWP, and SVR increased significantly following CO reduction. The cardiac cavity became larger while LVEF decreased after CO was decreased by 25% and 50%.
  
  
  CONCLUSIONS
  Canine model of ACI can be successfully established by right ventricular pacing following ligation of the LAD.
authors.affiliation: Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. xajngo@fimmu.com
authors.forename: Jin-Guo
authors.initials: JG
authors.lastname: Xie
authors.forename: Wen-Chao
authors.initials: WC
authors.lastname: Ou
authors.forename: Zheng-Cheng
authors.initials: ZC
authors.lastname: Xiu
authors.forename: Ping
authors.initials: P
authors.lastname: Zeng
authors.forename: Yi-Li
authors.initials: YL
authors.lastname: Liu
mesh_terms: D000818:Animals; D002303:Cardiac Output, Low / Q000209:etiology; D002304:Cardiac Pacing, Artificial; D003331:Coronary Vessels; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D008026:Ligation; D008297:Male