Centromeric chromatin makes its mark.
Post-translational modifications of core histones, particularly in the N terminus, seem to define different chromatin states in the genome. For instance, actively transcribed regions of euchromatin have a completely different set of 'marks' compared with silent heterochromatin. Recent analyses surprisingly demonstrate that, in addition to containing the histone H3 variant CENP-A, the centromeric chromatin that underlies the kinetochore bears a distinct combination of histone H3 modifications.
Dunleavy
Elaine
E
Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK.
Pidoux
Alison
A
Allshire
Robin
R
D000595:Amino Acid Sequence; D002503:Centromere / Q000737:chemistry*; D002843:Chromatin / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D006657:Histones / Q000737:chemistry / Q000378:metabolism; D008969:Molecular Sequence Data; D011499:Protein Processing, Post-Translational
D002843:Chromatin; D006657:Histones