A chiral molecular recognition approach to the formation of optically active quaternary centres in aza-Henry reactions.
An approach to asymmetric catalysis based on chiral molecular recognition by the combination of chiral Lewis acids and chiral organocatalysis for the formation of optically active quarternary centers in the aza-Henry reaction is presented; this procedure leads to products with up to 98% ee and a diastereomeric ratio of 14 : 1 in excellent yields with catalyst loadings of 5 mol%.
Knudsen
Kristian Rahbek
KR
Danish National Research Foundation: Center for Catalysis, Department of Chemistry, Aarhus University, Denmark.
Jorgensen
Karl Anker
KA
D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D001372:Aza Compounds