Langerhans-cell histiocytosis: a clinical case without bone involvement.
BACKGROUND
Langerhans-cell histiocytosis (LCH) is a group of rare disorders histologically characterized by the proliferation of Langerhans cells. Multiple organs and systems may be involved by the disease. Typically, there is bone involvement and, less frequently, lesions may be found in the lungs, liver, lymph nodes, skin, and mucosae. Oral soft tissue lesions without bone involvement are rare.


METHODS
We report a case of a 23-year-old man with LCH detected by oral soft tissue, cutaneous, and lung lesions.


RESULTS
Due to the oral lesion diagnosis, important procedures were performed, which determined the staging of the disease.


CONCLUSIONS
Gingival lesions could be one of the first manifestations of LCH. The periodontist should recognize and detect this important pathology with oral involvement.
Manfredi
M
M
Department of Otorhino-Laryngology and Ophthalmology, Dental and Maxillo-Facial Sciences, Dentistry and Oral Medicine Section, University of Parma, Parma, Italy. maddalena.manfredi@unipr.it
Corradi
D
D
Vescovi
P
P
D000328:Adult; D018949:Antigens, CD1 / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D001847:Bone Diseases / Q000175:diagnosis / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D019226:Oral Ulcer / Q000473:pathology*; D009418:S100 Proteins / Q000032:analysis
D018949:Antigens, CD1; D015415:Biomarkers; C419393:CD1a antigen; D009418:S100 Proteins