[Significance of extracellular matrix determined by immunostains and histochemical stains in a case of pulmonary epithelioid hemangioendothelioma].
We have analyzed extracellular matrix(ECM) of a case of pulmonary epithelioid hemangioendothelioma (PEH). Type IV collagen and laminin were existed in the ECM and were condensed around the tumor cell nests in meshwork pattern. Elastica-van Gieson stain revealed elastic fibers in this meshwork. These findings suggested that enhanced basement membrane protein synthesis in PEH seems to be responsible for the accumulation of abundant ECM. Analysis of the ECM seems to be quite useful for the differential diagnosis of this tumor.
Saito
Hideo
H
Aichi Health Promotion Foundation, Nagoya 462-0844.
Ishida
Mitsuaki
M
Kakutani
Aki
A
Kushima
Ryoji
R
Yamamoto
Kazuo
K
Chano
Tokuhiro
T
Okabe
Hidetoshi
H
D000328:Adult; D003094:Collagen / Q000032:analysis; D004396:Coloring Agents; D005109:Extracellular Matrix / Q000378:metabolism*; D016326:Extracellular Matrix Proteins / Q000032:analysis; D005260:Female; D018323:Hemangioendothelioma, Epithelioid / Q000473:pathology*; D006801:Humans; D007158:Immunologic Techniques; D008175:Lung Neoplasms / Q000473:pathology*
D004396:Coloring Agents; D016326:Extracellular Matrix Proteins; D003094:Collagen