title: Regulation of dendritic development by calcium signaling.
abstract: Neuronal activity can have profound effects on dendrite morphology in the developing brain. The effects of neuronal activity on dendritic morphology are mediated by calcium signaling. While many effects of calcium on dendrite structure occur locally at the site of calcium entry into the cytoplasmic milieu, elevation of cytoplasmic calcium is also translated into changes in gene transcription. Decoding the calcium signal into specific changes in gene transcription involve coordinating the action of a number of kinases, phosphatases, transcription factors and transcriptional coactivators. This review focuses on the contribution of calcium-dependent transcription on the control of dendritic morphology.
authors.affiliation: Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA. lredmond@mail.mcg.edu
authors.forename: Lori
authors.initials: L
authors.lastname: Redmond
authors.forename: Anirvan
authors.initials: A
authors.lastname: Ghosh
mesh_terms: D000818:Animals; D050882:CREB-Binding Protein; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D003712:Dendrites / Q000502:physiology*; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism
chemical_list: D017362:Cyclic AMP Response Element-Binding Protein; D009687:Nuclear Proteins; C481041:Ss18l1 protein, rat; D015534:Trans-Activators; D050882:CREB-Binding Protein; C494363:CREBBP protein, human; D002118:Calcium