Transcutaneous absorption of oil in preterm babies--a pilot study.
This study was conducted to determine transcutaneous absorption of oil in preterm neonates. A mixture of coconut oil and Meadowfoam oil which contains unique fatty acids, which acted as marker fatty acids was applied to the skin of babies. One mL blood was collected before and one hour after post oil application. Both pre and post oil application serum samples were hydrolysed and derivatised with 2-phenyl hydrazine hydrochloride in order to detect fatty acids by HPLC analysis on C-8 column. None of the pre oil application serum sample showed the presence of the marker fatty acids. The post oil application serum sample of all the 12 babies showed the presence of marker fatty acids of Meadowfoam oil which indicates transcutaneous absorption of oil in preterm babies.
Fernandez
A R
AR
Department of Neonatology, L.T.M.G. Hospital and L.T.M.M. College, Sion, Mumbai, India. rfern1@bom2vsnl.net.in
Krishnamoorthy
G
G
Patil
N
N
Mondkar
J A
JA
Swar
B D
BD
D000287:Administration, Topical; D015415:Biomarkers / Q000097:blood; D000074263:Coconut Oil; D003059:Cocos; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D010865:Pilot Projects; D010938:Plant Oils / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012869:Skin Absorption
D015415:Biomarkers; D010938:Plant Oils; C514846:meadowfoam oil; D000074263:Coconut Oil