title: Inhibition of herpes simplex virus replication by phosphonoacetic acid.
abstract: Replication of herpes simplex virus in WI-38 cells was inhibited by phosphonoacetic acid, as measured by decreased virus cytopathogenic effect and incorporation of radiolabeled thymidine in virus-infected cells. The drug appeared to have no effect on adsorption, penetration, or release of the virus nor on the synthesis of ribonucleic acid or protein. It appeared to inhibit virus deoxyribonucleic acid synthesis.
authors.forename: L R
authors.initials: LR
authors.lastname: Overby
authors.forename: E E
authors.initials: EE
authors.lastname: Robishaw
authors.forename: J B
authors.initials: JB
authors.lastname: Schleicher
authors.forename: A
authors.initials: A
authors.lastname: Rueter
authors.forename: N L
authors.initials: NL
authors.lastname: Shipkowitz
authors.forename: J C
authors.initials: JC
authors.lastname: Mao
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D005347:Fibroblasts / Q000821:virology; D006801:Humans; D010746:Phosphonoacetic Acid / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects* / Q000502:physiology; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D010746:Phosphonoacetic Acid