[PPARs and hypertension].
PPARs (peroxisome proliferator-activated receptors) alpha, delta and gamma are expressed in adipocytes, skeletal myocytes and hepatocytes and also in endothelial cells, vascular smooth muscle cells and monocytes/macrophages, in distinct distributions. They are critically involved in the pathophysiology of obesity, diabetes, hyperlipidemia and hypertension, the complex of which is recognized as "metabolic syndrome", as well as, of their vascular complications. In addition to modulation of insulin sensitivity, PPARs can regulate oxidative stress and local production of various vasoactive substances in blood vessels, and thus control vascular tone and remodeling as one of the determinants of hypertension.
Itoh
Hiroshi
H
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine.
D000818:Animals; D042783:Endothelial Cells / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D007333:Insulin Resistance / Q000502:physiology; D024821:Metabolic Syndrome / Q000503:physiopathology; D047492:Peroxisome Proliferator-Activated Receptors / Q000819:agonists / Q000502:physiology*
D047492:Peroxisome Proliferator-Activated Receptors