title: A chiral molecular recognition approach to the formation of optically active quaternary centres in aza-Henry reactions.
abstract: An approach to asymmetric catalysis based on chiral molecular recognition by the combination of chiral Lewis acids and chiral organocatalysis for the formation of optically active quarternary centers in the aza-Henry reaction is presented; this procedure leads to products with up to 98% ee and a diastereomeric ratio of 14 : 1 in excellent yields with catalyst loadings of 5 mol%.
authors.affiliation: Danish National Research Foundation: Center for Catalysis, Department of Chemistry, Aarhus University, Denmark.
authors.forename: Kristian Rahbek
authors.initials: KR
authors.lastname: Knudsen
authors.forename: Karl Anker
authors.initials: KA
authors.lastname: Jorgensen
mesh_terms: D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001372:Aza Compounds