title: Ewing's sarcoma of the humerus mimicking fibrous dysplasia on imaging and biological behavior.
abstract: We present the case of a 12-year-old girl who presented with a pathological fracture through a benign-appearing osteolytic lesion that was presumed to represent fibrous dysplasia. The fracture healed, and over the next 2.5 years there was further refracturing and healing with progressive osteolysis. A biopsy was performed and revealed Ewing's sarcoma. The disease was locally controlled by neoadjuvant chemotherapy and radiation therapy. The patient is disease free with excellent function 6 years following the discovery of the lesion. We illustrate and discuss the sequence of events.
authors.affiliation: Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA. sundarm@ccf.org
authors.forename: Murali
authors.initials: M
authors.lastname: Sundaram
authors.forename: Carrie Y
authors.initials: CY
authors.lastname: Inwards
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Shives
authors.forename: Peter M
authors.initials: PM
authors.lastname: Anderson
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000628:therapy; D002648:Child; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005260:Female; D005357:Fibrous Dysplasia of Bone / Q000000981:diagnostic imaging*; D005598:Fractures, Spontaneous / Q000209:etiology*; D006801:Humans; D006811:Humerus / Q000000981:diagnostic imaging* / Q000473:pathology; D011859:Radiography; D012512:Sarcoma, Ewing / Q000150:complications / Q000000981:diagnostic imaging* / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents