title: Conventional and microwave-assisted conversion of substituted 3-amino-oxazolidin-2,4-diones into N',N'-disubstituted alpha-hydroxyhydrazides.
abstract: Substituted 3-amino-oxazolidin-2,4-diones have been prepared by reacting cyanohydrins or alpha-hydroxyesters subsequently with 1,1'-carbonyldiimidazole and 1,1-disubstituted hydrazines followed by acidic hydrolysis in case of the intermediate 3-amino-4-imino-oxazolidin-2-ones. Conventional and microwave-assisted syntheses of N',N'-disubstituted alpha-hydroxyhydrazides have been accomplished by reacting substituted 3-amino-oxazolidin-2,4-diones with catalytic amounts of sodium methoxide in methanol.
authors.affiliation: Institute of Pharmacy, University of Hamburg, Bundesstrasse 45, 20146 Hamburg, Germany. kurz@chemie.uni-hamburg.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Kurz
authors.forename: Khalid
authors.initials: K
authors.lastname: Widyan
mesh_terms: D020650:Combinatorial Chemistry Techniques; D006834:Hydrazines / Q000138:chemical synthesis*; D008872:Microwaves; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry; D023303:Oxazolidinones / Q000737:chemistry*
chemical_list: D006834:Hydrazines; D009570:Nitriles; D023303:Oxazolidinones; C430593:cyanohydrin