title: Cholestasis in children with portal vein obstruction.
abstract: We describe cholestasis as a result of bile duct abnormalities in 8 children with portal vein obstruction. In a clinical, biochemical and radiological investigation of 121 children with cavernous transformation of the portal vein seen between 1986 and 2000, 8 presented with jaundice, pruritus, and/or raised serum aminotransferases and/or gamma glutamyl transpeptidase (gamma GT) activities. Each displayed dilation and narrowing of intra- and/or extrahepatic bile ducts. Surgical decompression of the portal system (portal-systemic or Rex anastomosis) resulted in the regression of the signs of cholestasis in all children. We conclude that children with portal vein obstruction may exhibit clinically significant cholestasis as a result of external compression of the bile duct by the cavernoma.
authors.affiliation: Division of Hepatology, Hôpital Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin Bicêtre cedex, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Gauthier-Villars
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Franchi
authors.forename: Frédéric
authors.initials: F
authors.lastname: Gauthier
authors.forename: Monique
authors.initials: M
authors.lastname: Fabre
authors.forename: Danièle
authors.initials: D
authors.lastname: Pariente
authors.forename: Olivier
authors.initials: O
authors.lastname: Bernard
mesh_terms: D002648:Child; D002675:Child, Preschool; D002779:Cholestasis / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D011169:Portal Vein / Q000601:surgery; D014652:Vascular Diseases / Q000150:complications / Q000601:surgery; D014656:Vascular Surgical Procedures