title: Effects of hypoglycemia on developmental outcome in children with congenital hyperinsulinism.
abstract: Children with congenital hyperinsulinism are at risk for recurring, severe episodes of hypoglycemia that can cause seizures, brain damage, and developmental delay. To assess the frequency of permanent brain damage in this disorder, we carried out a telephone survey of 68 children who presented to The Children's Hospital of Philadelphia between 1980 and 2000. One third of the group had some degree of developmental delay. Those presenting in the first week of life and those with medically unresponsive hyperinsulinism were more likely to have delays. Early recognition and control of hypoglycemia are essential for preventing developmental delay in these children.
authors.affiliation: Department of Endocrinology, The Children's Hospital of Philadephia, PA 19104, USA. ljsteinkrauss@hotmail.com
authors.forename: Linda
authors.initials: L
authors.lastname: Steinkrauss
authors.forename: Terri H
authors.initials: TH
authors.lastname: Lipman
authors.forename: Christine D
authors.initials: CD
authors.lastname: Hendell
authors.forename: Marsha
authors.initials: M
authors.lastname: Gerdes
authors.forename: Paul S
authors.initials: PS
authors.lastname: Thornton
authors.forename: Charles A
authors.initials: CA
authors.lastname: Stanley
mesh_terms: D017677:Age Distribution; D020208:Brain Injury, Chronic / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D044903:Congenital Hyperinsulinism / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D002658:Developmental Disabilities / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D006306:Health Surveys; D006776:Hospitals, Pediatric; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007361:Intelligence Tests; D008297:Male; D024802:Nurse's Role; D010371:Pediatric Nursing; D015143:Philadelphia / Q000453:epidemiology; D012307:Risk Factors; D012640:Seizures / Q000209:etiology; D011795:Surveys and Questionnaires