title: Atherosclerosis-like lesions of the aortic valve are common in adults of all ages: a necropsy study.
abstract: OBJECTIVE
  To determine the presence and size of atherosclerosis-like lesions in aortic valves of unselected adults of all ages.
  
  
  METHODS
  Necropsy study.
  
  
  METHODS
  Departments of Forensic Medicine and Pathology at the University of Oulu and the Oulu University Hospital in Finland.
  
  
  METHODS
  48 consecutive unselected adult subjects (15 subjects aged 20-40 years, 17 aged 41-60, and 16 aged >or= 61) undergoing necropsy.
  
  
  METHODS
  Detection of the presence of atherosclerosis-like lesions and mineralisation in aortic valves, and morphometrical measurement of the size of lesions.
  
  
  RESULTS
  None of the necropsy subjects had aortic stenosis and only two subjects had macroscopic calcification of the aortic valve. Of 48 subjects, however, 45 had an atherosclerosis-like subendothelial thickening above the elastic lamina on the aortic side of at least one of the valve leaflets. Of 15 young subjects aged 20-40 years, eight had a lesion in the right coronary cusp of the aortic valve and 12 had a lesion in at least one of the three aortic valve leaflets. Of 17 middle aged subjects, 16 had an early lesion in the right coronary cusp and all had a lesion in at least one of the valve leaflets. In the oldest age group, all 16 subjects had a lesion in every valve leaflet. The mean lesion area in the three valve leaflets varied from 0.1-0.2 mm(2) in young subjects, 0.5-0.8 mm(2) in middle aged, and 1.3-2.3 mm(2) in elderly subjects (p < 0.001). Microscopic calcification in the right coronary cusp of the aortic valve was observed in 12 of 17 middle aged and 14 of 16 elderly subjects but only in one young subject.
  
  
  CONCLUSIONS
  Atherosclerosis-like lesions in the aortic valve are prevalent in adults of all age groups, including young subjects aged 20-40 years, suggesting that the disease process leading to aortic stenosis is common, often beginning in early adulthood.
authors.affiliation: Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland. johanna.kuusisto@kuh.fi <johanna.kuusisto@kuh.fi>
authors.forename: J
authors.initials: J
authors.lastname: Kuusisto
authors.forename: K
authors.initials: K
authors.lastname: Räsänen
authors.forename: T
authors.initials: T
authors.lastname: Särkioja
authors.forename: E
authors.initials: E
authors.lastname: Alarakkola
authors.forename: V-M
authors.initials: VM
authors.lastname: Kosma
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D001021:Aortic Valve / Q000473:pathology*; D001161:Arteriosclerosis / Q000473:pathology*; D001344:Autopsy; D002114:Calcinosis / Q000473:pathology; D003327:Coronary Disease / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged