title: Melanoma genetics and the development of rational therapeutics.
abstract: Melanoma is a cancer of the neural crest-derived cells that provide pigmentation to skin and other tissues. Over the past 4 decades, the incidence of melanoma has increased more rapidly than that of any other malignancy in the United States. No current treatments substantially enhance patient survival once metastasis has occurred. This review focuses on recent insights into melanoma genetics and new therapeutic approaches being developed based on these advances.
authors.affiliation: Veterans Affairs Palo Alto Healthcare System, Palo Alto, California, USA.
authors.forename: Yakov
authors.initials: Y
authors.lastname: Chudnovsky
authors.forename: Paul A
authors.initials: PA
authors.lastname: Khavari
authors.forename: Amy E
authors.initials: AE
authors.lastname: Adams
mesh_terms: D000818:Animals; D006801:Humans; D008545:Melanoma / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D018631:ras Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D018631:ras Proteins