title: Genotoxicity of antimicrobial endodontic compounds by single cell gel (comet) assay in Chinese hamster ovary (CHO) cells.
abstract: OBJECTIVE
  In the current study, the potential DNA damage associated with exposure to a number of antimicrobial endodontic compounds was assessed by the single cell gel (comet) assay in vitro.
  
  
  METHODS
  Chinese hamster ovary (CHO) cells were exposed to formocresol, paramonochlorophenol, calcium hydroxide, or chlorhexidine at final concentration ranging from 0.01% to 1%.
  
  
  RESULTS
  Formocresol, paramonochlorophenol, and calcium hydroxide, as well as chlorhexidine in all concentrations tested did not contribute to the DNA damage.
  
  
  CONCLUSIONS
  These findings are clinically relevant since they represent an important contribution to the correct evaluation of the potential health risk associated with exposure to dental agents.
authors.affiliation: Department of Pathology, Botucatu Medical School -- São Paulo State University, Botucatu, Brazil. ak92@hotmail.com
authors.forename: Daniel Araki
authors.initials: DA
authors.lastname: Ribeiro
authors.forename: Clarissa
authors.initials: C
authors.lastname: Scolastici
authors.forename: Patricia Lepage Alves
authors.initials: PL
authors.lastname: De Lima
authors.forename: Mariangela Esther Alencar
authors.initials: ME
authors.lastname: Marques
authors.forename: Daisy Maria Favero
authors.initials: DM
authors.lastname: Salvadori
mesh_terms: D000818:Animals; D000891:Anti-Infective Agents, Local / Q000633:toxicity*; D016466:CHO Cells / Q000187:drug effects; D002126:Calcium Hydroxide / Q000633:toxicity; D002710:Chlorhexidine / Q000633:toxicity; D002733:Chlorophenols / Q000633:toxicity; D020552:Comet Assay; D006224:Cricetinae; D003412:Cricetulus; D004249:DNA Damage; D005566:Formocresols / Q000633:toxicity; D012388:Root Canal Irrigants / Q000633:toxicity*
chemical_list: D000891:Anti-Infective Agents, Local; D002733:Chlorophenols; D005566:Formocresols; D012388:Root Canal Irrigants; C031025:formocresol; C029107:4-chlorophenol; D002126:Calcium Hydroxide; D002710:Chlorhexidine