In vivo induction of sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) by lynestrenol.
Genotoxicity study of synthetic progestin lynestrenol, was carried out on mouse bone marrow cells using sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) as parameters. Lynestrenol was studied at three different doses (6.87, 13.75 and 27.50 mg/kg body wt.). SCE and CA increased significantly as compared to normal control when treated with lynestrenol at 13.75 and 27.50 mg/kg body wt. The present results suggest that lynestrenol has both a genotoxic and cytotoxic effects in mouse bone marrow cells.
Siddique
Yasir Hasan
YH
Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh 202 002, India. yasir_hasansiddique@rediffmail.com
Afzal
Mohammad
M
D000818:Animals; D001835:Body Weight; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D002869:Chromosome Aberrations; D003280:Contraceptives, Oral, Synthetic / Q000494:pharmacology; D004249:DNA Damage; D005260:Female; D008234:Lynestrenol / Q000494:pharmacology*; D051379:Mice; D012854:Sister Chromatid Exchange
D003280:Contraceptives, Oral, Synthetic; D008234:Lynestrenol