Prostaglandins of the E-series inhibit connective tissue proliferation in the liver wound of the rat.
The present study was undertaken to relate wound healing of an internal organ to prostaglandins of the E and F series. A small liver wound was induced by a galvanic cauter via the abdominal route under general anesthesia and prostaglandin E1, E2 and F2alpha were injected twice daily at a dose of 250 microg/kg. Proliferation of the connective tissue in the liver wound was estimated morphometrically 6 days after liver wound infliction. Levels of prostaglandins E2 and F2alpha were measured in the liver wound as well as in normal liver tissue from adjacent lobes using radioimmunoassay. The results show that exogenous prostaglandins of the E-series suppress connective tissue proliferation. Three minutes after the last prostaglandin E2 injection, high prostaglandin concentrations were measured both in the liver wound and in the liver tissue of the adjacent lobe. Prostaglandin F2alpha injections had no effect on wound healing. We believe that the rat thermic liver wound model can be used for different studies on wound healing mechanisms and that prostaglandins of the E-series are involved in wound healing in the specific time period studied.
Arend
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A
Department of Anatomy, University of Tartu, Biomedicum, Ravila 19, 51014 Tartu, Estonia. arend@ut.ee
Aunapuu
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M
Masso
R
R
Selstam
G
G
D000527:Alprostadil / Q000494:pharmacology; D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D003238:Connective Tissue / Q000187:drug effects / Q000473:pathology*; D015237:Dinoprost / Q000494:pharmacology; D015232:Dinoprostone / Q000494:pharmacology; D008107:Liver Diseases / Q000473:pathology*; D011458:Prostaglandins E / Q000494:pharmacology*; D051381:Rats; D014947:Wounds and Injuries / Q000473:pathology*
D011458:Prostaglandins E; D015237:Dinoprost; D000527:Alprostadil; D015232:Dinoprostone