title: [Mechanical recanalization in acute stroke treatment].
abstract: The development of endovascular techniques for the treatment of acute stroke began with the introduction of local intra-arterial fibrinolysis. In parallel to designing new systemic therapy approaches, catheter systems for loosening, disintegrating, or removing cerebral thrombi have undergone assessment in recent years to serve as alternatives or supplements to fibrinolytic treatment. Mechanical alteration of intracranial thrombi with balloon catheters, manipulations with the guide wire, or ultrasound waves transmitted into the vascular system as well as techniques for thrombus aspiration, snare extraction, or more complex hydrodynamic or laser-guided thrombectomy systems have been tested in feasibility studies, which evidenced basic functionality and relative safety. Broad clinical applications outside of the clinical trial setting cannot yet be recommended since the new catheter systems are still in early phase clinical testing.
authors.affiliation: Institut für Neuroradiologie, Klinikum der Johann-Wolfgang-Goethe-Universität, Frankfurt am Main. Berkefeld@em.uni-frankfurt.de
authors.forename: J
authors.initials: J
authors.lastname: Berkefeld
authors.forename: R
authors.initials: R
authors.lastname: du Mesnil de Rochemont
authors.forename: M
authors.initials: M
authors.lastname: Sitzer
authors.forename: F E
authors.initials: FE
authors.lastname: Zanella
mesh_terms: D000208:Acute Disease; D002404:Catheterization / Q000379:methods*; D003422:Critical Care / Q000379:methods; D006801:Humans; D020767:Intracranial Thrombosis / Q000150:complications / Q000601:surgery*; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D020521:Stroke / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*; D017131:Thrombectomy / Q000379:methods*; D015912:Thrombolytic Therapy / Q000379:methods*; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000379:methods*