[Genetic predisposition and susceptibility to mycobacterial infections: the IL-12-IFNgamma axis deficiency].
Since ten years severe pediatric infections which were idiopathic have now molecular explanation, defined new primary immunodeficiencies. These children presented a new kind of hereditary immunodeficiency with severe and/or recurrent infections caused by only one micro-organisms family. Some of these children have mycobacterial infections. Standard immunologic explorations were normal. However, they presented a vulnerability, sometimes lethal caused by Mycobacteria. The goal of this article is to describe the IL-12-IFNgamma axis deficiency (mendelian susceptibility to mycobacterial disease).
Picard
C
C
Unité d'Immunologie-Hématologie Pédiatrique, Hôpital Necker-Enfants Malades, Paris.
Casanova
J L
JL
D020022:Genetic Predisposition to Disease; D006801:Humans; D007371:Interferon-gamma / Q000172:deficiency*; D018664:Interleukin-12 / Q000172:deficiency*; D009164:Mycobacterium Infections / Q000235:genetics* / Q000276:immunology*
D018664:Interleukin-12; D007371:Interferon-gamma