title: [Results of dynamic cytogenetic study of children and teenagers living in areas, radioactive by contaminated after the Chernobyl accident].
abstract: Results of multiyear cytogenetic study of children and teenagers living in areas, radioactive by contaminated after Chernobyl accident, were adduced. Mean density of 137Cs contamination in two compared living areas were 111 and 200 kBq/m2 and mean external doses accumulated for 1986-2001 were 6.7 and 11.4 mGy correspondingly. Averaged thyroid doses receives by subjects of all age groups in the second area were approximately 1.5 times higher than in the first area; in the youngest group (0-1 year) the doses were 114.3 and 174.3 mGy. During 17 years cytogenetic investigation approximately from 30% to 60% of examined persons were observed the increased level of chromosome aberrations in lymphocytes of peripheral blood. Average frequency of unstable aberrations (acentrics, dicentrics and centric rings) constituted about 0.4 per 100 cells (0.22 per 100 cells in controls) during all period of observation. Level of marker aberrations (dicentrics and centric rings) was increased almost all times of study and varied within 0.04-0.19 per 100 cell (0.03 in control group). The parallel investigation of frequency of stable aberrations by FISH method showed up their level about 3 times exceeding observed dicentrics level. Comparably higher indexes of cytogenetic disturbances were revealed in group exposed in utero during period of accident.
authors.forename: A V
authors.initials: AV
authors.lastname: Sevan'kaev
authors.forename: G F
authors.initials: GF
authors.lastname: Mikhaĭlova
authors.forename: O I
authors.initials: OI
authors.lastname: Potetnia
authors.forename: V V
authors.initials: VV
authors.lastname: Tsepenko
authors.forename: I K
authors.initials: IK
authors.lastname: Khvostunov
authors.forename: E V
authors.initials: EV
authors.lastname: Golub
authors.forename: V S
authors.initials: VS
authors.lastname: Piatenko
authors.forename: O V
authors.initials: OV
authors.lastname: Pozdyshkina
authors.forename: N N
authors.initials: NN
authors.lastname: Shepel'
authors.forename: E G
authors.initials: EG
authors.lastname: Matveenko
mesh_terms: D000293:Adolescent; D002588:Cesium Radioisotopes / Q000633:toxicity; D047852:Chernobyl Nuclear Accident; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D015331:Cohort Studies; D020732:Cytogenetic Analysis; D004307:Dose-Response Relationship, Radiation; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000528:radiation effects; D008297:Male; D018788:Radioactive Hazard Release; D011848:Radioactive Pollutants / Q000633:toxicity*; D013961:Thyroid Gland / Q000528:radiation effects
chemical_list: D002588:Cesium Radioisotopes; D011848:Radioactive Pollutants