title: Malignant fibrous histiocytoma of the breast. Report of two cases and review of the literature.
abstract: Sarcomas of the breast are uncommon, accounting for less than 1% of all primary malignancies. Among these tumors, malignant fibrous histiocytoma (MFH) is very rare. Two cases of this neoplasm are reported, with histological findings and surgical treatment. The issue of radiation-induced lesions after surgery for carcinoma and the necessity for a correct preoperative diagnosis is examined. A review of the available literature evaluates the histopathological and biological features of MFH of the breast, for which there are no prospective trials, owing to the rarity of this kind of neoplasm. The extent of surgery or role of axillary lymph nodes dissection and multimodality therapy are discussed.
authors.affiliation: Department of Surgery "Pietro Valdoni", University of Rome "La Sapienza", Italy. alessandro.decesare@tin.it
authors.forename: Alessandro
authors.initials: A
authors.lastname: De Cesare
authors.forename: Enrico
authors.initials: E
authors.lastname: Fiori
authors.forename: Antonio
authors.initials: A
authors.lastname: Burza
authors.forename: Antonio
authors.initials: A
authors.lastname: Ciardi
authors.forename: Marco
authors.initials: M
authors.lastname: Bononi
authors.forename: Luciano
authors.initials: L
authors.lastname: Izzo
authors.forename: Patrizia
authors.initials: P
authors.lastname: Volpino
authors.forename: Antonino
authors.initials: A
authors.lastname: Cavallaro
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Cangemi
mesh_terms: D000328:Adult; D000368:Aged; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D005347:Fibroblasts / Q000378:metabolism; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008327:Mammography; D013997:Time Factors