title: Inhibitory effect of jaceosidin isolated from Artemisiaargyi on the function of E6 and E7 oncoproteins of HPV 16.
abstract: Jaceosidin (4',5,7-trihydroxy-3',6-dimethoxyflavone) was isolated from Artemisia argyi as a putative oncogene inhibitor. Jaceosidin inhibited binding between oncoprotein E6 of the human papillomavirus and the p53 tumor suppressor protein. In addition, jaceosidin inhibited binding between the E7 oncoprotein and the Rb tumor suppressor protein, and also inhibited the function of HPV-16 harboring cervical cancer cells, including SiHa and CaSki. Collectively, jaceosidin inhibited the functions of the E6 and E7 oncoproteins of the human papillomavirus, suggesting that this compound might be used as a potential drug for the treatment of cervical cancers associated with the human papillomavirus.
authors.affiliation: Laboratory of Cell Biology, Korea Research Institute of Bioscience and Biotechnology, Yuseong P.O. Box 115, Daejeon 305-600, Korea.
authors.forename: Hee-Gu
authors.initials: HG
authors.lastname: Lee
authors.forename: Kyung-Ae
authors.initials: KA
authors.lastname: Yu
authors.forename: Won-Keun
authors.initials: WK
authors.lastname: Oh
authors.forename: Tae-Woong
authors.initials: TW
authors.lastname: Baeg
authors.forename: Hyun-Cheol
authors.initials: HC
authors.lastname: Oh
authors.forename: Jong-Seog
authors.initials: JS
authors.lastname: Ahn
authors.forename: Won-Cheoul
authors.initials: WC
authors.lastname: Jang
authors.forename: Jong-Wan
authors.initials: JW
authors.lastname: Kim
authors.forename: Jong-Seok
authors.initials: JS
authors.lastname: Lim
authors.forename: Yong-Kyung
authors.initials: YK
authors.lastname: Choe
authors.forename: Do-Young
authors.initials: DY
authors.lastname: Yoon
mesh_terms: D019306:Artemisia; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009856:Oncogene Proteins, Viral / Q000187:drug effects* / Q000378:metabolism; D050725:Papillomavirus E7 Proteins; D018515:Plant Leaves; D012097:Repressor Proteins / Q000187:drug effects* / Q000378:metabolism; D014407:Tumor Cells, Cultured / Q000187:drug effects*; D002583:Uterine Cervical Neoplasms
chemical_list: C068651:E6 protein, Human papillomavirus type 16; D005419:Flavonoids; D009856:Oncogene Proteins, Viral; D050725:Papillomavirus E7 Proteins; D012097:Repressor Proteins; C059731:oncogene protein E7, Human papillomavirus type 16; C477508:jaceosidin