[Pharmacokinetics of the methylprednisolone, dexamethasone and hydrocortisone in the inner ear after administered via round window].
OBJECTIVE
To compare the pharmacokinetics of Methylprednisolone, Dexamethasone and Hydrocortisone in the inner era of guinea pig after administered via round window.


METHODS
Guinea pig was divided into groups chronologically. After a drop of 100 g/L corticosteroid applied into the round window niche, the tympanic perilymph was sampled chronologically. Concentration of the three corticosteroid in perilymph were measured via HPLC and analyzed by 3P97 software.


RESULTS
The highest concentration of the three drug appeared at 30 min, 60 min and 30 min. Then the concentration declined rapidly.


CONCLUSIONS
All three corticosteroid permeate the round window membrane easily, but the concentration declined rapidly after the peak appearing.
Li
Sui
S
Department of Otolaryngology, Union Hospital, Wuhan, China.
Gong
Shusheng
S
Chen
Jianguo
J
Lu
Haitao
H
Wang
Jibao
J
D000287:Administration, Topical; D000818:Animals; D003907:Dexamethasone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007758:Ear, Inner / Q000378:metabolism*; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D010498:Perilymph / Q000378:metabolism*; D012405:Round Window, Ear
D003907:Dexamethasone; D006854:Hydrocortisone; D008775:Methylprednisolone