Long-term results of trabeculectomy with different concentrations of mitomycin C in refractory developmental glaucoma.
OBJECTIVE
To evaluate the long-term results of trabeculectomy with two different concentrations of mitomycin C in refractory developmental glaucoma.


METHODS
A total of 48 eyes of 37 patients with previous failure of congenital glaucoma surgery underwent mitomycin C-augmented trabeculectomy. Data were analyzed retrospectively, and patients were divided into two groups. Group 1 consisted of 18 patients (25 eyes) who underwent trabeculectomy with a 0.4 mg/mL mitomycin C solution and group 2 consisted of 19 patients (23 eyes) who underwent trabeculectomy with a 0.2 mg/mL mitomycin C solution. Pre- and postoperative intraocular pressure (IOP), best-corrected visual acuity, bleb characteristics, success rate, and complications were compared for both groups.


RESULTS
Mean time between primary surgery and mitomycin C-augmented trabeculectomy was 19.3 months (range, 11 months to 7 years). Mean preoperative IOP was 28.4 +/- 2.9 mm Hg in group 1 and 29.0 +/- 2.4 mm Hg in group 2. Final postoperative IOP was 17.0 +/- 1.6 for group 1 and 17.1 +/- 1.4 mm Hg for group 2. There were no significant differences between the groups for IOP, success rate, and complications (P > .05). The most common postoperative complication was shallow anterior chamber (11 [22.9%] of 48 eyes).


CONCLUSIONS
A 0.4 or 0.2 mg/mL mitomycin C solution for 4 minutes may be used during trabeculectomy in refractory developmental glaucoma.
Ozkiris
Abdullah
A
Erciyes University Medical Faculty, Kayseri, Turkey.
Tamcelik
Nevbahar
N
D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005260:Female; D005901:Glaucoma / Q000151:congenital / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007223:Infant; D007429:Intraocular Pressure / Q000187:drug effects; D008137:Longitudinal Studies; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage* / Q000627:therapeutic use; D009994:Osmolar Concentration; D012086:Reoperation; D012189:Retrospective Studies; D014130:Trabeculectomy; D016896:Treatment Outcome
D016685:Mitomycin