title: Bilateral thalamic deep brain stimulation: midline tremor control.
abstract: OBJECTIVE
  To determine the efficacy of bilateral deep brain stimulation (DBS) for management of midline tremor (head, voice, tongue, trunk) in patients with essential tremor.
  
  
  METHODS
  Prospective assessment of tremor at baseline (presurgical), and postoperatively at 1, 3, and 12 months, and annually thereafter.
  
  
  METHODS
  A clinical series of 22 individuals undergoing staged, bilateral DBS for treatment of essential tremor. The tremor rating scale was the primary outcome measure.
  
  
  RESULTS
  Midline tremor showed significant improvement with stimulation "on" at nearly every postoperative interval when compared with stimulation "off" and with baseline tremor. Bilateral stimulation was associated with a significant incremental improvement in midline tremor control compared with unilateral stimulation: average "stimulation on" percentage change in midline tremor from the unilateral to bilateral period was 81%. Head and voice tremor showed the most consistent improvement. Among those requiring a change in stimulation parameters because of side effects, dysarthria, disequilibrium, motor disturbances, and paraesthesiae were the most common. Dysarthria was more common with bilateral (n = 6; 27%) than with unilateral (n = 0) stimulation. Stimulation parameters remained largely unchanged after the first three months. Nine of 44 leads placed (20%) required subsequent repositioning or replacement.
  
  
  CONCLUSIONS
  Unilateral thalamic stimulation significantly improves midline tremor, and subsequent bilateral thalamic stimulation offers an additional incremental improvement in midline tremor control.
authors.affiliation: Department of Neurology, Mayo Clinic Jacksonville, FL 32224, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Putzke
authors.forename: R J
authors.initials: RJ
authors.lastname: Uitti
authors.forename: A A
authors.initials: AA
authors.lastname: Obwegeser
authors.forename: Z K
authors.initials: ZK
authors.lastname: Wszolek
authors.forename: R E
authors.initials: RE
authors.lastname: Wharen
mesh_terms: D000368:Aged; D046690:Deep Brain Stimulation / Q000295:instrumentation*; D004401:Dysarthria / Q000453:epidemiology / Q000628:therapy; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D009069:Movement Disorders / Q000453:epidemiology / Q000628:therapy; D010292:Paresthesia / Q000453:epidemiology / Q000628:therapy; D011446:Prospective Studies; D013788:Thalamus / Q000503:physiopathology*; D014202:Tremor / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy*