Microbleeds in hereditary cerebral hemorrhage with amyloidosis-Dutch type.
In a hereditary variant of cerebral amyloid angiopathy (CAA), cerebral hemorrhage with amyloidosis-Dutch type, supratentorial microbleeds were found to occur independently of the presence of hypertension, whereas hypertension probably contributed to the development of cerebellar microbleeds. This predictable hereditary variant of CAA may be a useful model to study microbleeds in relation to CAA.
van den Boom
R
R
Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands. r.van_den_boom@lumc.nl
Bornebroek
M
M
Behloul
F
F
van den Berg-Huysmans
A A
AA
Haan
J
J
van Buchem
M A
MA
D000328:Adult; D000367:Age Factors; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D001921:Brain / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D015984:Causality; D028243:Cerebral Amyloid Angiopathy, Familial / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D002536:Cerebral Arteries / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000175:diagnosis* / Q000453:epidemiology* / Q000235:genetics; D015897:Comorbidity; D004252:DNA Mutational Analysis; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D012737:Sex Factors
D053327:Apolipoprotein E4; D001057:Apolipoproteins E