Oncolytic viruses for cancer therapy II. Cell-internal factors for conditional growth in neoplastic cells.
Recent advances in our understanding of virus-host interactions have fueled new studies in the field of oncolytic viruses. The first part of this review explained how cell-external factors, such as cellular receptors, influence tumor tropism and specificity of oncolytic virus candidates. In the second part of this review, we focus on cellinternal factors that mediate tumor-specific virus growth. An oncolytic virus must be able to replicate within cancerous cells and kill them without collateral damage to healthy surrounding cells. This desirable property is inherent to some proposed oncolytic viral agents or has been achieved by genetic manipulation in others.
Campbell
Stephanie A
SA
Deptartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
Gromeier
Matthias
M
D000818:Animals; D017353:Gene Deletion; D005818:Genetic Engineering / Q000379:methods; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors / Q000008:administration & dosage*; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000628:therapy* / Q000821:virology*; D011991:Receptors, Virus; D014779:Virus Replication; D014780:Viruses / Q000235:genetics*
D011991:Receptors, Virus