Evaluating associations between 5-HTTLPR polymorphism and Alzheimer's disease for Korean patients.
There has been growing evidence that the serotonin (5-HT) system is important in the regulation of memory and thus might be associated with Alzheimer's disease (AD), while research results on this issue have been inconsistent. The 5-HT system has also been suggested to be responsible for a significant portion of the behavioural aspects of AD. This study aimed to investigate the associations of the 5-HT transporter gene linked polymorphic region (5-HTTLPR) polymorphism with AD and delusional/aggressive symptoms of AD in Korean samples of 65 patients and 43 controls. The 5-HTTLPR polymorphism was neither associated with AD nor with delusional/aggressive symptoms of AD. It was suggested that phenotypic expression of the 5-HTTLPR polymorphism might be varied according to ethnic differences.
Ha
Tae Min
TM
Department of Neuropsychiatry, School of Medicine, Busan, and Woosan Medical Foundation, Hyung Ju Hospital, Yangsan, Republic of Korea.
Cho
Deuk Man
DM
Park
Sung Woo
SW
Joo
Myung Jin
MJ
Lee
Bong Ju
BJ
Kong
Bo Geum
BG
Kim
Jae Min
JM
Yoon
Jin Sang
JS
Kim
Young Hoon
YH
D000368:Aged; D000374:Aggression; D000544:Alzheimer Disease / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D003072:Cognition Disorders / Q000175:diagnosis; D015331:Cohort Studies; D003702:Delusions / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007723:Korea; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins
D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins