Expedient synthesis and design strategies for new peptoid construction.
[reaction: see text] A range of peptoids can be prepared efficiently using microwave-assisted solid-phase chemistry in a commercial reactor. This method is most effective for the installation of electronically deactivated benzylic amines. The systematic incorporation of these amines into peptoids can deliver oligomers capable of displaying unique and stable structural motifs-microwave-assisted solid-phase synthesis will enable their future study and application.
Gorske
Benjamin C
BC
Department of Chemistry, 1101 University Avenue, University of Wisconsin, Madison, Wisconsin 53706-1322, USA.
Jewell
Sarah A
SA
Guerard
Emily J
EJ
Blackwell
Helen E
HE
D020650:Combinatorial Chemistry Techniques / Q000295:instrumentation* / Q000379:methods*; D008872:Microwaves; D015394:Molecular Structure; D034444:Peptoids / Q000138:chemical synthesis*
D034444:Peptoids