Cerebral Whipple's disease as a cause of reversible dementia.
We describe a case of reversible dementia caused by Tropheryma whippelii (TW). Diagnosis was confirmed by a positive polymerase chain reaction for this pathogen both on serum and cerebrospinal fluid. Specific antibiotic therapy resulted in distinct clinical and neuroradiological improvement. Control polymerase chain reaction for T. whippelii on serum and cerebrospinal fluid was negative.
Rossi
T
T
Unità Operativa di Neurologia, Ospedale Geriatrico Sestilli, I.N.R.C.A., Ancona, Italy. t.rossi@inrca.it
Haghighipour
R
R
Haghighi
M
M
Paolini
S
S
Scarpino
O
O
D000368:Aged; D000900:Anti-Bacterial Agents; D002494:Central Nervous System Infections / Q000150:complications* / Q000188:drug therapy; D003704:Dementia / Q000382:microbiology*; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D006801:Humans; D012074:Remission Induction; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D008061:Whipple Disease / Q000150:complications* / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination