title: Prognostic impact of aortic calcification index and ankle-arm blood pressure index in patients under hemodialysis.
abstract: The mortality rate is high in patients receiving hemodialysis (HD), atherosclerotic diseases being the major cause of death. As marker of clinical outcome, a prospective examination of atherosclerotic tests and atherosclerotic risk factors in patients receiving HD was performed. On April 2000, 84 patients receiving HD were followed up until April 2002. At entry to the study, several atherosclerotic tests, including ankle-arm blood pressure index (API), aortic calcification index (ACI), and atherosclerotic risk factors, were performed. In 36 patients with old thrombotic events, 26 had new thrombotic events. Of 48 patients without previous thrombotic events, 15 had new thrombotic events. During 2 years, 41 patients had new thrombotic events and 15 patients died due to thrombotic disorders. The HD durations were significantly longer in non-survivors than survivors and the body mass index was lower in non-survivors than survivors. There was a significant difference in the values of ACI and API between survivors and non-survivors, and between patients with and without thrombotic events. These findings suggest that the ACI and API have a prognostic value because they might predict the occurrence of thrombosis.
authors.affiliation: Second Department of Internal Medicine, Mie University School of Medicine, Tsu-city, Mie-Ken, Japan.
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Kushiya
authors.forename: Hideo
authors.initials: H
authors.lastname: Wada
authors.forename: Miho
authors.initials: M
authors.lastname: Sakakura
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Mori
authors.forename: Esteban C
authors.initials: EC
authors.lastname: Gabazza
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Nishikawa
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nobori
authors.forename: Mitsuya
authors.initials: M
authors.lastname: Noguchi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Izumi
authors.forename: Takahiro
authors.initials: T
authors.lastname: Nakasaki
authors.forename: Mikio
authors.initials: M
authors.lastname: Takagi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shiku
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000842:Ankle / Q000502:physiology*; D001011:Aorta / Q000473:pathology* / Q000503:physiopathology*; D001132:Arm / Q000502:physiology*; D001161:Arteriosclerosis / Q000473:pathology; D015415:Biomarkers; D001794:Blood Pressure / Q000502:physiology*; D002114:Calcinosis; D005260:Female; D006490:Hemostatics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D006435:Renal Dialysis; D015996:Survival Rate
chemical_list: D015415:Biomarkers; D006490:Hemostatics