title: [Effects of Alternanthera philoxeroides Griseb against dengue virus in vitro].
abstract: OBJECTIVE
  To investigate the effects of Alternanthera philoxeroides Griseb extracts against dengue virus in vitro.
  
  
  METHODS
  MTT assay and observation of cytopathic effect (CPE) were carried out to determine the cytotoxicity of Alternanthera philoxeroides Griseb on C6/36 cell lines and its effects on dengue virus.
  
  
  RESULTS
  None of the 4 kinds of Alternanthera philoxeroides Griseb extracts exhibited obvious cytotoxicity on the cells at different concentrations with the exception of that over 320 microg/ml. The 4 extracts all showed inhibitory effects on dengue virus. Statistical analysis of TD(50) and ED(50) by Probit regression method suggested that extracts from coumarin had the lowest toxicity on the cells (TD(50)=535.91), whereas extracts from petroleum ether showed the strongest inhibitory effects on dengue virus (ED(50)=47.43) among the 4 extracts.
  
  
  CONCLUSIONS
  Alternanthera philoxeroides Griseb possesses antiviral effects on dengue virus in vitro.
authors.affiliation: Medical Research Center of People's Hospital of Guangdong Province, Guangzhou 510080, China. jwenling@126.com
authors.forename: Wen-Ling
authors.initials: WL
authors.lastname: Jiang
authors.forename: Xian-Ling
authors.initials: XL
authors.lastname: Luo
authors.forename: Su-Juan
authors.initials: SJ
authors.lastname: Kuang
mesh_terms: D027703:Amaranthaceae / Q000737:chemistry*; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000633:toxicity; D003716:Dengue Virus / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal