title: Acute paralysis following "a bad potato": a case of botulism.
abstract: OBJECTIVE
  Intensivists often encounter patients with respiratory failure as a result of neuromuscular disease, however, acute neuro-muscular syndromes are less common. We present a case of food borne Clostridium botulism and discuss the diagnostic and therapeutic considerations.
  
  
  RESULTS
  A 35-yr-old healthy male presented with abdominal pain and blurred vision 12 hr after ingesting a "bad" potato. During the next 17 hr, the patient demonstrated a gradual descending paralysis which ultimately resulted in no cranial nerve function and 0/5 strength in all extremities. Sensation was intact. The patient required intubation and mechanical ventilation. His blood count, biochemical profile, computerized tomography and magnetic resonance imaging of the head were normal. A lumbar puncture revealed no abnormalities. Due to the rapid deterioration and presentation of 'descending' paralysis, botulism was suspected. The patient was treated empirically with botulinum anti-toxin. Samples of blood, stool and gastric contents were cultured for the presence of Clostridium botulinum and its toxin and these tests were positive for botulinum toxin A 12 days later. The patient's neuromuscular function gradually improved over a prolonged period of time. Six and one-half months after his initial presentation, the patient was discharged home after completing an aggressive rehabilitation program.
  
  
  CONCLUSIONS
  Botulism is a rare syndrome and presents as an acute, afebrile, descending paralysis beginning with the cranial nerves. If suspected, botulinum anti-toxin should be considered, particularly within the first 24 hr of onset of symptoms. Confirmation of the presence of botulinum requires days therefore the diagnosis and management rely on history and physical examination.
authors.affiliation: Program in Critical Care Medicine and Respiratology, University of Western Ontario, London, Ontario, Canada.
authors.forename: Mohit
authors.initials: M
authors.lastname: Bhutani
authors.forename: Edward
authors.initials: E
authors.lastname: Ralph
authors.forename: Michael D
authors.initials: MD
authors.lastname: Sharpe
mesh_terms: D000208:Acute Disease; D000328:Adult; D001906:Botulism / Q000150:complications* / Q000628:therapy; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D010243:Paralysis / Q000175:diagnosis / Q000209:etiology*