title: Flunarizine for prophylactic treatment of childhood migraine.
abstract: OBJECTIVE
  To determine the effectiveness of flunarizine for migraine prophylaxis in children.
  
  
  METHODS
  Children aged between 7 and 15 years who had the indication for prophylactic treatment of migraine were recruited into a prospective study at the Department of Pediatrics, Ramathibodi Hospital, from January 1st to December 31st 1999. After verbal consent was obtained, flunarizine was administered either at 5-mg daily in those who had never received it or at 10-mg daily in those who previously took this drug within one year Serial evaluation for the severity of migraine including duration, intensity, and frequency of headache attacks was performed every 2 weeks for 6 months.
  
  
  RESULTS
  Twenty-one children (10 boys, 11 girls) with a mean age of 11.3+/-2.48 years (range 7-15 years) were enrolled in the study. There were ten children who had migraine with aura. Initially, 5-mg daily and 10-mg daily of flunarizine were administered in 19 and 2 patients respectively. The dosage was increased to 10-mg daily after two weeks in 5 patients because of the unresponsiveness to the initial dose. Improvement was observed in 14 patients (66%) including 13 of 14 patients who received 5-mg daily and 1 of 7 patients who received 10 mg daily. Five patients (23%) had no recurrent attack. Nine patients (42%) had more than 50%-reduction of frequency of migraine and 3 of these had either shorter duration or less intensity of the attack. Clinical improvement was observed between 2 and 4 weeks after initiation of treatment. There was no adverse effect observed
  
  
  CONCLUSIONS
  This is a preliminary result demonstrating that flunarizine is one of the effective drugs for migraine prophylaxis in children.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand. raavs@mahidol.ac.th
authors.forename: Anannit
authors.initials: A
authors.lastname: Visudtibhan
authors.forename: Apasri
authors.initials: A
authors.lastname: Lusawat
authors.forename: Surang
authors.initials: S
authors.lastname: Chiemchanya
authors.forename: Pongsakdi
authors.initials: P
authors.lastname: Visudhiphan
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D005444:Flunarizine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000517:prevention & control*; D011446:Prospective Studies; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D014665:Vasodilator Agents; D005444:Flunarizine