title: Incidence and prevalence of multiple sclerosis in Newfoundland and Labrador.
abstract: BACKGROUND
  The incidence and prevalence of multiple sclerosis (MS) in Newfoundland and Labrador (NL) had been reported in 1984 and was considered to be relatively low at that time. This study revisits the incidence and prevalence of MS in NL for the year 2001.
  
  
  METHODS
  Case searches through patient files of neurologists in NL were conducted. A complete list of patients billed for MS in NL between 1996 and 2003 was obtained and all cases were confirmed via chart review.
  
  
  RESULTS
  There were 493 living MS patients yielding a prevalence of 94.4/100,000 which is significantly higher than previously reported. Of the living patients, 330 had relapsing remitting (RRMS), 94 had secondary progressive, 66 had primary progressive (PPMS) and three had unspecified MS. The total female to male ratio was 2.7:1. There was no difference between the female to male ratios for RRMS vs PPMS. Patients with PPMS had a later onset compared to RRMS (p<0.00001). Yearly incidences were relatively constant from 1994 to 2001 (5.6/100,000). Significant delays between first symptoms and final diagnosis were common and the delay time has not changed over the past 15 years. A prevalence of 88.9/100,000 was estimated from survival and incidence trends and was not significantly different than the measured prevalence (p=0.38).
  
  
  CONCLUSIONS
  The increase in incidence and prevalence are accounted for through both better access to diagnostic facilities and more practicing neurologists. The revised prevalence and incidence are more in keeping with recently reported values throughout Canada.
authors.affiliation: Faculty of Medicine (Neurology), Memorial University of Newfoundland, St. John's, NL, Canada. p97jss@mun.ca
authors.forename: J S
authors.initials: JS
authors.lastname: Sloka
authors.forename: W E M
authors.initials: WE
authors.lastname: Pryse-Phillips
authors.forename: M
authors.initials: M
authors.lastname: Stefanelli
mesh_terms: D017668:Age of Onset; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D009103:Multiple Sclerosis / Q000453:epidemiology*; D020528:Multiple Sclerosis, Chronic Progressive / Q000453:epidemiology; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000453:epidemiology; D009523:Newfoundland and Labrador / Q000453:epidemiology; D015995:Prevalence