title: [Anaplastic carcinoma of the thyroid gland with chondrosarcomatous component].
abstract: The case of an 83-year-old female with a history of a two months enlarging goiter is presented. Clinically, a firm goiter with fixation to surrounding soft tissues was found. Fine needle aspiration cytology was performed with the conclusion of a sarcomatoid variant of anaplastic carcinoma of the thyroid gland; biopsy was recommended. The patient was operated on and died six months after operation with metastatic dissemination in lymphatic nodes and lungs. Histologically, an invasive high-grade tumor composed of irregular, sometimes bizarre spindled or polygonal cells intermingled with foci of chondroid tissue was seen. The cartilage comprised lobularly arranged chondrocytes with irregular nuclei; bi- or multinucleated chondrocytes were present as well. The diagnosis of thyroid anaplastic carcinoma with chondrosarcomatous component was established. Differential diagnostics of this tumour is discussed.
authors.affiliation: Fingerlandův ústav patologie, LF UK a FN, Hradec Králové. lacoj@lfhk.cuni.cz
authors.forename: J
authors.initials: J
authors.lastname: Laco
authors.forename: A
authors.initials: A
authors.lastname: Ryska
authors.forename: P
authors.initials: P
authors.lastname: Celakovský
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000473:pathology*; D002813:Chondrosarcoma / Q000473:pathology*; D005260:Female; D006801:Humans; D013964:Thyroid Neoplasms / Q000473:pathology*