title: Six-helix bundles designed from DNA.
abstract: We present a designed cyclic DNA motif that consists of six DNA double helices that are connected to each other at two crossover sites. DNA double helices with 10.5 nucleotide pairs per turn facilitate the programming of DNA double crossover molecules to form hexagonally symmetric arrangements when the crossover points are separated by seven or fourteen nucleotide pairs. We demonstrate by atomic force microscopy well-formed arrays of hexagonal six-helix bundle motifs both in 1D and in 2D.
authors.affiliation: Department of Chemistry, New York University, New York, New York 10003, USA.
authors.forename: Frederick
authors.initials: F
authors.lastname: Mathieu
authors.forename: Shiping
authors.initials: S
authors.lastname: Liao
authors.forename: Jens
authors.initials: J
authors.lastname: Kopatsch
authors.forename: Tong
authors.initials: T
authors.lastname: Wang
authors.forename: Chengde
authors.initials: C
authors.lastname: Mao
authors.forename: Nadrian C
authors.initials: NC
authors.lastname: Seeman
mesh_terms: D001483:Base Sequence; D003434:Crossing Over, Genetic; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D018625:Microscopy, Atomic Force; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation
chemical_list: D004247:DNA