[The association of autoimmune thyroiditis with HLA-B8 in the Georgian population].
The study of distribution of HLA antigens among Georgian population in case of autoimmune thyreoiditis revealed a statistically significant association of HLA-B8 antigen with autoimmune thyreoiditis. For statistical analysis we used following criterion: relative risk, attributive risk, preventive fraction, correlation coefficient and immunogenetic correction (P). Without compatibility to these criteria, there were no associations of the HLA antigens with the diseases. Although 8 of the antigens gave relative risk more than one, but only HLA B8 gave real association with autoimmune thyreoiditis. Typing of HLA antigens of class I and class II loci was done by classic microlymphocytotoxic test. The test performed on the lymphocytes from patients with autoimmune thyreoiditis. The character of association of HLA antigens among Georgian population with Hashimoto disease differs in character from other populations that evidently can be explained by the distributional character of HLA antigens among normal Georgian population.
Karseladze
Ts E
TsE
Meunargiia
V V
VV
Metreveli
D S
DS
Chagiashvili
Ts N
TsN
Chechelashvili
N T
NT
D003627:Data Interpretation, Statistical; D005846:Georgia (Republic) / Q000453:epidemiology; D015795:HLA-B8 Antigen / Q000097:blood*; D006801:Humans; D013967:Thyroiditis, Autoimmune / Q000453:epidemiology / Q000276:immunology*
D015795:HLA-B8 Antigen