title: Antioxidant activities of three dihydrochalcone glucosides from leaves of Lithocarpus pachyphyllus.
abstract: In vitro antioxidant activities of three sweet dihydrochalcone glucosides from the leaves of Lithocarpus pachyphyllus (Kurz) Rehd. (Fagaceae), trilobatin 2"-acetate (1), phloridzin (2) and trilobatin (3), were investigated. The IC50 (50% inhibitory concentration) values for compounds 1-3 of lipid peroxidation in rat liver homogenate were 261, 28, 88 microM, respectively. Compounds 1-3 increased superoxide dismutase (SOD) activity with EC50 (50% effective concentration) values of 575, 167, 128 microM, and glutathione peroxidase (GSH-Px) activity with EC50 values of 717, 347, 129 microM, respectively, and showed only weak DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity.
authors.affiliation: Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming 650204, P R China.
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Yang
authors.forename: Ji-Kai
authors.initials: JK
authors.lastname: Liu
authors.forename: Xiang-Dong
authors.initials: XD
authors.lastname: Qin
authors.forename: Wan-Lin
authors.initials: WL
authors.lastname: Wu
authors.forename: Zhi-He
authors.initials: ZH
authors.lastname: Chen
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification* / Q000494:pharmacology; D001713:Biphenyl Compounds; D002599:Chalcone / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D047188:Chalcones; D029962:Fagaceae / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005960:Glucosides; D005979:Glutathione Peroxidase / Q000378:metabolism; D006834:Hydrazines; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D010851:Picrates; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D047188:Chalcones; D016166:Free Radical Scavengers; D005960:Glucosides; D006834:Hydrazines; D010851:Picrates; D002599:Chalcone; C004931:1,1-diphenyl-2-picrylhydrazyl; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; C015812:dihydrochalcone