[Marrow stromal cells and repair of bone defect].
OBJECTIVE
To review researches on the relation between marrow stromal cells (MSCs) and repair of bone defect.


METHODS
The latest original literatures about marrow stromal cells and their use in the treatment of bone defect were extensively reviewed.


RESULTS
Marrow stromal cells were induced to osteoblasts under proper conditions and showed the potential of bone formation in vivo. The methods of bone tissue engineering using MSCs as seed cells and gene therapy using MSCs as target cells were both useful in the repair of bone defect.


CONCLUSIONS
MSCs have a promising future in the repair of bone defect.
Peng
Songlin
S
Department of Orthopaedics, Tongji Hospital, Tongji Medical College of Huazhong Science and Technology University, Wuhan Hubei 430030, PR China.
Fang
Huang
H
Luo
Yongxiang
Y
D000818:Animals; D001847:Bone Diseases / Q000235:genetics / Q000628:therapy; D001854:Bone Marrow Cells / Q000166:cytology* / Q000378:metabolism; D001842:Bone and Bones / Q000293:injuries / Q000601:surgery*; D002454:Cell Differentiation; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D010006:Osteoblasts / Q000166:cytology; D017154:Stromal Cells / Q000166:cytology* / Q000378:metabolism; D023822:Tissue Engineering / Q000379:methods*