Spinal rhabdomyosarcoma in a child with lipomyelomeningocele.
Malignant tumors arising within dysrhaphic malformations are very rare and are mostly teratomas; so far, only one rhabdomyosarcoma has been reported in this context. We report another case of a girl with lipomyelomeningocele who developed a lumbar rhabdomyosarcoma 2 years after birth and primary closure of the neural tube defect. We present clinical, radiological and pathological findings, discuss possible mechanisms of malignant transformation and review the literature.
Wagner
Wolfgang
W
Department of Neurosurgery, Section of Pediatric Neurosurgery, University Hospitals, Mainz, Germany. wagner@nc.klinik.uni-mainz.de
Koch
Dorothee
D
D002675:Child, Preschool; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae; D008591:Meningomyelocele / Q000150:complications*; D018233:Rhabdomyosarcoma, Embryonal / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D012447:Sacrum; D013120:Spinal Cord Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery