Evaluation of hydroxypropyl-beta-cyclodextrin in the treatment of aldicarb poisoning in rats.
Cyclodextrins are ring-shaped oligosaccharides with a hydrophilic exterior and a hydrophobic interior. The interior cavity is capable of complexing fat-soluble molecules small enough to fit inside. Sprague-Dawley rats were used to evaluate the efficacy of hydroxypropyl-beta-cyclodextrin as treatment of aldicarb poisoning in rats. Survival times in the majority of rats dosed with aldicarb and receiving intravenous cyclodextrin were longer compared with the control rats only dosed with aldicarb per os.
Verster
R S
RS
Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, 0110 South Africa.
Botha
C J
CJ
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000284:Administration, Oral; D000448:Aldicarb / Q000506:poisoning*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005079:Excipients / Q000627:therapeutic use*; D007275:Injections, Intravenous / Q000662:veterinary; D007306:Insecticides / Q000506:poisoning*; D008297:Male; D011041:Poisoning / Q000188:drug therapy / Q000662:veterinary; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D016896:Treatment Outcome; D047392:beta-Cyclodextrins / Q000627:therapeutic use*
D005079:Excipients; D007306:Insecticides; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000448:Aldicarb