title: New members of the insulin family: regulators of metabolism, growth and now ... reproduction.
abstract: Insulin, IGF, and relaxin are established members of the insulin protein superfamily. The application of the techniques of cellular, molecular, and computational biology has permitted the identification of new insulin-like ligands and their cognate receptors. Information regarding the biologic role is available for some of these newly identified ligand-receptor systems and indicates novel roles in diverse processes such as testicular descent, germ cell function, and cell migration.
authors.affiliation: Department of Pediatrics, C.S. Mott Children's Hospital, University of Michigan Medical School, Ann Arbor 48109, USA.
authors.forename: Chunxia
authors.initials: C
authors.lastname: Lu
authors.forename: Hien N
authors.initials: HN
authors.lastname: Lam
authors.forename: Ram K
authors.initials: RK
authors.lastname: Menon
mesh_terms: D000818:Animals; D002465:Cell Movement; D005260:Female; D005854:Germ Cells / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000235:genetics / Q000502:physiology*; D008024:Ligands; D008297:Male; D010802:Phylogeny; D011506:Proteins / Q000502:physiology; D012098:Reproduction; D015398:Signal Transduction; D013737:Testis / Q000033:anatomy & histology
chemical_list: D007328:Insulin; C084797:Leydig insulin-like protein; D008024:Ligands; D011506:Proteins