title: Prevention of coronary atherosclerosis by the use of combination therapy with antioxidant coenzyme Q10 and statins.
abstract: The goal of the present research was to assess the efficacy of combination treatment with antioxidant coenzyme Q10 and simvastatin as well as coenzyme Q10 without statin therapy in order to prevent coronary atherosclerosis. 42 outpatients were divided into 2 groups: receiving coenzyme Q10 (Hasco-Lek, Poland) 60mg daily and its combination with simvastatin (zocor, vasilip) 10mg daily for an 8-week period. The treatment with coenzyme Q10 demonstrated its potential independent role in positive modification of oxidative stress, antiatherogenic fraction of lipid profile, atherogenic ratio, platelet aggregability. Taking into consideration the obtained results the study supports the use of coenzyme Q10 in combination with statins. Suggested attractive approach may result in complete correction of dislipidemia, reverse of endothelial dysfunction, reduce degree of oxidative stress and platelet aggregability. Consequently such a combination may be beneficial in preventing of further development of atherosclerosis in native coronary arteries as well as in bypass grafts in all coronary heart disease patients with or without myocardial revascularization.
authors.forename: G
authors.initials: G
authors.lastname: Chapidze
authors.forename: S
authors.initials: S
authors.lastname: Kapanadze
authors.forename: N
authors.initials: N
authors.lastname: Dolidze
authors.forename: Z
authors.initials: Z
authors.lastname: Bachutashvili
authors.forename: N
authors.initials: N
authors.lastname: Latsabidze
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D003067:Coenzymes; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000097:blood / Q000517:prevention & control*; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy / Q000601:surgery; D003627:Data Interpretation, Statistical; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D018384:Oxidative Stress; D010974:Platelet Aggregation; D019821:Simvastatin / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D003067:Coenzymes; D000960:Hypolipidemic Agents; D008055:Lipids; D014280:Triglycerides; D014451:Ubiquinone; D009569:Nitric Oxide; D019821:Simvastatin; C024989:coenzyme Q10