title: Neurovirulence of H7N7 influenza A virus: brain stem encephalitis accompanied with aspiration pneumonia in mice.
abstract: A mouse-adapted influenza A virus, A/equine/London/1416/73-MA (H7N7) caused viral pneumonia, ganglionitis and encephalitis after intranasal inoculation in mice. Virological and pathological data suggested that this virus spreads to the brain by both hematogenous and transneuronal routes, and produces encephalitic lesions similar to those seen in mice infected with H5 highly pathogenic avian influenza A viruses by intranasal infection. Some mice infected with this strain were affected by aspiration pneumonia, which may be caused by neurogenic dysfunction of the pharyngeal/laryngeal reflex due to brain stem encephalitis.
authors.affiliation: Graduate School of Medicine, Tohoku University, Sendai, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Shinya
authors.forename: A
authors.initials: A
authors.lastname: Suto
authors.forename: M
authors.initials: M
authors.lastname: Kawakami
authors.forename: H
authors.initials: H
authors.lastname: Sakamoto
authors.forename: T
authors.initials: T
authors.lastname: Umemura
authors.forename: Y
authors.initials: Y
authors.lastname: Kawaoka
authors.forename: N
authors.initials: N
authors.lastname: Kasai
authors.forename: T
authors.initials: T
authors.lastname: Ito
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology / Q000821:virology*; D004195:Disease Models, Animal; D018792:Encephalitis, Viral / Q000473:pathology / Q000821:virology*; D005260:Female; D045888:Ganglion Cysts / Q000473:pathology; D007116:Immunization, Passive; D007249:Inflammation / Q000473:pathology; D053126:Influenza A Virus, H7N7 Subtype; D009980:Influenza A virus / Q000472:pathogenicity*; D008168:Lung / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D009976:Orthomyxoviridae Infections / Q000473:pathology / Q000628:therapy / Q000821:virology*; D011014:Pneumonia / Q000473:pathology / Q000821:virology*; D014774:Virulence