CRP after 2004.
C-reactive protein (CRP) that has been conserved throughout evolution is a host-defense molecule. Its attraction towards phosphocholine-ligands, such as modified low-density lipoprotein, and apoptotic cells leads to the "masking" of these substances that have the capabilities to otherwise engage in deleterious activities. Complement activation by CRP complexes and the modulation by CRP of complement activation by its ligands add up to its beneficial effects. In the presence of CRP, production of membrane-damaging last product of the complement pathway is arrested. CRP is currently serving as an indicator of cardiovascular diseases, but to pinpoint the role of CRP in atherosclerosis, a drug that can lower cholesterol levels, but not the CRP levels, is needed for experimentation.
Agrawal
Alok
A
Department of Pharmacology, East Tennessee State University, P.O. Box 70577, Johnson City, TN 37614, USA. agrawal@estu.edu
D000818:Animals; D002097:C-Reactive Protein / Q000276:immunology / Q000502:physiology*; D015922:Complement C1q / Q000502:physiology; D006801:Humans; D010767:Phosphorylcholine / Q000378:metabolism
D010767:Phosphorylcholine; D015922:Complement C1q; D002097:C-Reactive Protein