title: [Markers of thrombophilia in patients with retinal vein thrombosis].
abstract: BACKGROUND
  Thrombophilia is an alteration of hemostasis that increases the risk to venous or arterial thrombosis. This condition may be the underlying cause of retinal vein thrombosis.
  
  
  OBJECTIVE
  To study the presence of thrombophilia in patients with retinal vein thrombosis.
  
  
  METHODS
  Prospective study of 55 patients aged 22 to 86 years, with retinal vein thrombosis (central or branch). Antithrombin III, coagulant protein C, functional protein S, resistance to activated C protein, homocysteine, prothrombin G20210A gene, lupus anticoagulant and anticardiolipin antibodies were measured in all.
  
  
  RESULTS
  Seventeen patients had thrombophilic markers (antiphospholipid syndrome in seven, hyperhomocysteinemia in six and resistance to protein C in three). Of these 17 patients, 53% had high blood pressure, 35% an abnormal serum lipid profile and 23% a personal history of thrombosis. The thrombosis was central in 12 (ischemic in four) and of a branch in five (ischemic in two).
  
  
  CONCLUSIONS
  Thrombophilic markers must be assessed in patients with retinal vein thrombosis.
authors.affiliation: Servicio de Oftalmología, Hospital Clínico de la Universidad de Chile, Chile. ltraipe@entelchile.net
authors.forename: Leonidas
authors.initials: L
authors.lastname: Traipe
authors.forename: Guillermo
authors.initials: G
authors.lastname: Conte
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Conte
authors.forename: Santiago
authors.initials: S
authors.lastname: Ibáñez
authors.forename: Patricio
authors.initials: P
authors.lastname: Meza
authors.forename: Basilio
authors.initials: B
authors.lastname: Rojas
authors.forename: Marianela
authors.initials: M
authors.lastname: Cuneo
authors.forename: Juan
authors.initials: J
authors.lastname: Verdaguer
mesh_terms: D020016:Activated Protein C Resistance / Q000150:complications; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001780:Blood Coagulation Tests; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018455:Protein S Deficiency / Q000097:blood; D012170:Retinal Vein Occlusion / Q000097:blood / Q000209:etiology*; D012307:Risk Factors; D017678:Sex Distribution; D019851:Thrombophilia / Q000097:blood / Q000150:complications*
chemical_list: D015415:Biomarkers