title: Psychophysiological stress-regulated gene expression in mice.
abstract: Eight genes showed significant changes in expression in mice under psychophysiological stress provided by cage-restraint and water-immersion. The transcription level of most of these genes was affected in all the tissues analyzed, and some of them were responsive genes in several different stress systems. Peculiarly, the expression level of one gene, cdc2-like kinase 1 (CLK1), was reduced only in the brain, while the balance of partially- and alternatively-spliced CLK1 mRNA species changed in all the tissues including the brain. These results suggest that some stress-response mechanisms, including transcriptional and post-transcriptional events, are coordinated in the whole body in mice under psychophysiological stress.
authors.affiliation: DNA Chip Research Inc., 1-1-43 Suehiro, Tsurumi, Yokohama 230-0045, Japan. murata@dna-chip.co.jp
authors.forename: Shigenori
authors.initials: S
authors.lastname: Murata
authors.forename: Taeko
authors.initials: T
authors.lastname: Yoshiara
authors.forename: Chun Ren
authors.initials: CR
authors.lastname: Lim
authors.forename: Maiko
authors.initials: M
authors.lastname: Sugino
authors.forename: Mitori
authors.initials: M
authors.lastname: Kogure
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ohnuki
authors.forename: Toshi
authors.initials: T
authors.lastname: Komurasaki
authors.forename: Kenichi
authors.initials: K
authors.lastname: Matsubara
mesh_terms: D000818:Animals; D018076:DNA, Complementary; D005786:Gene Expression Regulation; D017874:Immediate-Early Proteins; D007438:Introns; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009687:Nuclear Proteins / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013315:Stress, Psychological / Q000201:enzymology / Q000235:genetics*; D014158:Transcription, Genetic; D000099184:Serum-Glucocorticoid Regulated Kinases
chemical_list: D018076:DNA, Complementary; D017874:Immediate-Early Proteins; D009687:Nuclear Proteins; D017346:Protein Serine-Threonine Kinases; D011505:Protein-Tyrosine Kinases; D000099184:Serum-Glucocorticoid Regulated Kinases; C066780:Clk dual-specificity kinases