title: Ontogenetic changes in serum S100B in Down syndrome patients.
abstract: BACKGROUND
  It has been shown that Down syndrome (DS) patients have elevated S100B levels in brain tissue.
  
  
  METHODS
  Measurements of S100B were performed in serum samples from 48 DS patients and 42 ostensibly healthy age-matched controls.
  
  
  RESULTS
  We observed higher levels of S100B in the DS group than in the control group. Moreover, serum S100B in DS patients was not age-dependent as it is in normal individuals.
  
  
  CONCLUSIONS
  The higher levels of S100B in DS patients may reflect a general and persistent increase in the extracellular space and may be associated with neurodegenerative lesions observed in DS patients.
authors.affiliation: Dept. Bioquimica, ICBS, UFRGS, Rua Euripedes Monteiro Duarte 10/305, Porto Alegre, RS, 90830-250, Brazil. cristina.netto@ufrgs.br
authors.forename: Cristina B O
authors.initials: CB
authors.lastname: Netto
authors.forename: Luis V
authors.initials: LV
authors.lastname: Portela
authors.forename: Cristina T
authors.initials: CT
authors.lastname: Ferreira
authors.forename: Carlos
authors.initials: C
authors.lastname: Kieling
authors.forename: Ursula
authors.initials: U
authors.lastname: Matte
authors.forename: Têmis
authors.initials: T
authors.lastname: Felix
authors.forename: Themis Reverbel
authors.initials: TR
authors.lastname: da Silveira
authors.forename: Diogo O
authors.initials: DO
authors.lastname: Souza
authors.forename: Carlos-Alberto
authors.initials: CA
authors.lastname: Gonçalves
authors.forename: Roberto
authors.initials: R
authors.lastname: Giugliani
mesh_terms: D000375:Aging; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000097:blood*; D006801:Humans; D007223:Infant; D009414:Nerve Growth Factors / Q000097:blood*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*
chemical_list: D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human