[The study of the expression, effect and clinical relationship of TGF-beta1 CD44V6 bcl-2 and p53 in the larynx squamous carcinoma].
OBJECTIVE
This study was to measure the expression of TGF-beta1 in larynx squamous carcinoma, to investigate the relationship between TGF-beta1 and the expressions of CD44V5 , bcl-2 and p53, and the relationship between TGF-beta1 and pathological grading of tumours, the clinical staging and the survival rate of the patients, through which the effect of TGF-beta1 on the pathogenesis of the larynx squamous carcinoma was to be known.


METHODS
With immunohistochemistry, the expressions of TGF-beta1, CD44V6, bcl-2 and p53 were measured in the paraffin sections of the larynx squamous carcinoma tissues of 43 patients.


RESULTS
In pathological grading I, II, III, respectively, the positive expression ratios of TGF-beta1 were 86.96%, 82.35%, 100.00%; CD44V6 were 60.87%, 70.59%, 100.00%; bcl-2 were 82.61%, 94.12%, 100.00%; p53 were 26.09%, 35.29%, 66.67%.


CONCLUSIONS
(1) TGF-beta1 had some relationships to the pathological grading, the clinical staging, the metastasis to cervical lymph node, the survival rates of patients in 3 and 5 years. TGF-beta1 can be used as a marker to evaluate the development and predict the metastasis of tumors and the prognosis of patients. (2) The expression of TGF-beta1 in larynx carcinoma had some correlation to CD44V6, bcl-2 and p53.
Huang
Zhichun
Z
Department of Otolaryngology, Affiliated Zhongda Hospital of Southeast University, Nanjing, 210009, China.
Deng
Hong
H
Feng
Xu
X
Zhang
Fengbing
F
Jiang
Jingjuan
J
Liu
Dongfeng
D
D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000096:biosynthesis; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis; D053773:Transforming Growth Factor beta1 / Q000096:biosynthesis*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis
D018960:Hyaluronan Receptors; D019253:Proto-Oncogene Proteins c-bcl-2; D053773:Transforming Growth Factor beta1; D016159:Tumor Suppressor Protein p53