title: [Usage of Cerasorbe in complex treatment of chronic generalized periodontitis (clinical-experimental study)].
abstract: The effectiveness of the bioactive osteoplastic composition--Cerasorbe--at a surgical stage of combined treatment of chronic generalized periodontitis was examined. The results obtained in the study and the control groups prove, that Cerasorbe allows reduction of the treatment duration and achieves remission of the disease. From 127 patients with chronic generalized periodontitis 65 were operated by microplasmatic scalpel-irradiator as a part of a complex treatment. The treatment course comprised of 3-5 procedures. The quantity of manipulations was determined by the severity of the pathological process. Before and after the treatment the radiographical investigation was carried out in both groups. At the 18th month after the surgical intervention bone regeneration, confirmed by radiography, was shown in 87,8% cases in the study group and in 60,1% in the control group. The work presents experimental and morphological studies of regeneration of damaged areas of maxillo-facial bones. Time course of healing of defects in the lower jaw bone filled with Cerasorb was studied in experiment on rabbits. On days 7, 14, 21 and 28 four rabbits from each group were killed and the defects were investigation by X-ray and histological methods. We have stained the micropreparations by hematoxilin-eosine. In experiments with Cerasorb, bone regenerations replaced up to one half of the defect area by the day 28. We have shown high efficiency of Cerasorb in experiment and during complex treatment. Cerasorb stimulated reparative osteogenesis and can be recommended for using in the clinical practice.
authors.forename: N R
authors.initials: NR
authors.lastname: Motsonelidze
authors.forename: T V
authors.initials: TV
authors.lastname: Okropiridze
authors.forename: R V
authors.initials: RV
authors.lastname: Kapanadze
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001861:Bone Regeneration; D002130:Calcium Phosphates / Q000008:administration & dosage / Q000627:therapeutic use*; D002908:Chronic Disease; D004195:Disease Models, Animal; D017886:Durapatite / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000175:diagnosis / Q000601:surgery; D010518:Periodontitis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000601:surgery*; D011817:Rabbits; D011859:Radiography; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate; D017886:Durapatite