Inflammatory actinic keratoses secondary to systemic chemotherapy.
Traditionally, systemic 5-fluorouracil has been associated with a reaction that produces inflammation of preexisting and subclinical actinic keratoses (AKs). We report a case of an inflammatory reaction occurring in AKs secondary to the use of doxorubicin. The cutaneous reaction was successfully managed with the application of high-potency topical steroids over the body and with pain management. When the doxorubicin was discontinued and another agent (paclitaxel) was instituted, the cutaneous reaction gradually diminished.
Ilyas
Erum N
EN
Division of Dermatology, Department of Medicine, Cooper Health System, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, USA.
Grana
Generosa
G
Green
Justin J
JJ
D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy; D004317:Doxorubicin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007642:Keratosis / Q000188:drug therapy / Q000209:etiology*; D008875:Middle Aged; D014466:Ultraviolet Rays / Q000009:adverse effects*
D000305:Adrenal Cortex Hormones; D000970:Antineoplastic Agents; D004317:Doxorubicin