title: Hepatic failure in a child with anti-epileptic hypersensitivity syndrome.
abstract: An 11-year-old boy developed severe hypersensitivity reaction to phenobarbitone resulted in fulminant hepatic failure. During the course of illness, he developed clinical features compatible with severe acute respiratory syndrome (SARS) that may have complicated the recovery of his underlying hypersensitivity reaction, which was subsequently controlled with intravenous immune globulin and corticosteroids.
authors.affiliation: Department of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong. albertmli@cuhk.edu.hk
authors.forename: Albert M
authors.initials: AM
authors.lastname: Li
authors.forename: Edmund As
authors.initials: EA
authors.lastname: Nelson
authors.forename: Ellis K L
authors.initials: EK
authors.lastname: Hon
authors.forename: Frankie W T
authors.initials: FW
authors.lastname: Cheng
authors.forename: Dorothy F Y
authors.initials: DF
authors.lastname: Chan
authors.forename: Ngai Chuen
authors.initials: NC
authors.lastname: Sin
authors.forename: Kwok Chiu
authors.initials: KC
authors.lastname: Ma
authors.forename: Kam Lau
authors.initials: KL
authors.lastname: Cheung
authors.forename: Tai Fai
authors.initials: TF
authors.lastname: Fok
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D002648:Child; D004342:Drug Hypersensitivity / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D017114:Liver Failure, Acute / Q000150:complications* / Q000503:physiopathology; D008297:Male; D010634:Phenobarbital / Q000009:adverse effects*; D012640:Seizures / Q000188:drug therapy; D045169:Severe Acute Respiratory Syndrome / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000927:Anticonvulsants; D016756:Immunoglobulins, Intravenous; D010634:Phenobarbital