title: [Genotoxic and radioprotective properties of 2,5-diphenyloxazole and its derivatives on mice DNA structure in vivo].
abstract: The effects of 2,5-diphenyloxazole ad its derivatives suggested as nontraditional radioprotectors on mice spleen DNA structure were studied. The effects of these compounds were studied on intraperitoneal injection with and without subsequent X-ray exposure of mice to a dose of 12 cGy. The formation of double-strand breaks and DNA conformation change (by adsorption on NC filters) were recorded. A genotoxic effect of 2,5-diphenyloxazole and its derivatives, a nonlinearity of their dose-response relationships and different effects depending on the substance concentration were found. Some of the compounds exhibited radioprotective properties in certain concentration.
authors.forename: G P
authors.initials: GP
authors.lastname: Zhizhina
authors.forename: T M
authors.initials: TM
authors.lastname: Zavarykina
authors.forename: E B
authors.initials: EB
authors.lastname: Burlakova
authors.forename: V G
authors.initials: VG
authors.lastname: Noskov
authors.forename: F S
authors.initials: FS
authors.lastname: Dukhovich
mesh_terms: D000818:Animals; D004247:DNA / Q000032:analysis / Q000187:drug effects / Q000528:radiation effects*; D004249:DNA Damage; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D009153:Mutagens / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity*; D009690:Nucleic Acid Conformation / Q000187:drug effects / Q000528:radiation effects; D010080:Oxazoles / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D011837:Radiation-Protective Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D013154:Spleen / Q000737:chemistry / Q000528:radiation effects
chemical_list: D009153:Mutagens; D010080:Oxazoles; D011837:Radiation-Protective Agents; D004247:DNA; C009012:2,5-diphenyloxazole