[Effect of the metabolic syndrome on the electrophysiological parameters of the heart].
The goal of this research was to study influence of the MS on the electrophysiological parameters of the heart conduction system. The research involved 32 patients suffering from heart arrhythmias (18 females and 14 males, average age 52,8-/+12,9). The patients were categorized into 2 groups. Group I included 15 patients (9 females and 6 males, average age 47,5-/+8,9) suffering from heart arrhythmias and with signs of MS. Group I was subdivided into 2 subgroups: I subgroup--10 patients without diabetes, and II subgroup 5 patients with type II diabetes. Group II comprised of 17 patients (8 females and 9 males, average age 57,4-/+11,9) with arrhythmias without any signs of MS. The refractoriness dispersion between the right atrium (RA) and the left atrium (LA) caused by the MS, directly provokes development of atrial fibrillation and type II (atypical) atrial flutter. In cases of metabolic syndrome and "slow-fast" type of PRAVNT caused by the metabolic failures, the prolongation of the antegrade effective refractory period (ERP) of the slow AV nodal pathways and the retrograde ERP of the fast AV nodal pathways provoked prolongation of the tachycardia cycle and, consequently, reduction of the heart rate during paroxysms of tachycardia. Metabolic failures produce direct effect upon the sinus node function, causing suppression of its function as the SNSS develops, which requires implantation of pacemaker. The research results for metabolic syndrome and AV blockage cases demonstrated that the latter was always of a distal type, which was caused by a direct effect of metabolic failures upon the electrophysiology of the atrioventricular junction.
Kipshidze
N N
NN
Katsitadze
G A
GA
Khosroshvili
L B
LB
D000328:Adult; D001145:Arrhythmias, Cardiac / Q000209:etiology* / Q000601:surgery; D001281:Atrial Fibrillation / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D001282:Atrial Flutter / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D017115:Catheter Ablation; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D008875:Middle Aged; D013614:Tachycardia, Paroxysmal / Q000209:etiology / Q000503:physiopathology; D016896:Treatment Outcome