Musculoskeletal conditions of acute leukemia and malignant lymphoma in children.
We retrospectively reviewed 16 patients who presented to hospitals with orthopaedic complaints. Twelve patients experienced initial symptoms in the extremities and four patients had back pain. The leukocyte count was elevated in one patient, decreased in two patients, and normal in 13 patients. On radiographic examination, osteopenia was observed in 10 patients, osteolytic lesions were observed in five, and pathologic fractures were observed in five. Because the initial presentation of patients with leukemia often involves the musculoskeletal system, orthopaedists need to recognize the symptoms of this disease to avoid misdiagnosis and to expedite the initiation of appropriate potentially lifesaving treatment.
Kobayashi
Daisuke
D
Department of Orthopaedic Surgery, Kobe Children's Hospital, Kobe, Japan. k-daichan@ma7.seikyou.ne.jp
Satsuma
Shinichi
S
Kamegaya
Makoto
M
Haga
Nobuhiko
N
Shimomura
Satoshi
S
Fujii
Toshio
T
Yoshiya
Shinichi
S
D001851:Bone Diseases, Metabolic / Q000000981:diagnostic imaging; D001842:Bone and Bones / Q000473:pathology; D002097:C-Reactive Protein / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D005598:Fractures, Spontaneous / Q000000981:diagnostic imaging; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007223:Infant; D007596:Joints / Q000503:physiopathology*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007866:Leg / Q000503:physiopathology*; D007958:Leukocyte Count; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis*; D008297:Male; D010014:Osteolysis / Q000000981:diagnostic imaging; D010146:Pain / Q000209:etiology* / Q000503:physiopathology; D010522:Periostitis / Q000000981:diagnostic imaging; D010976:Platelet Count; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis*; D011859:Radiography; D012189:Retrospective Studies; D012598:Sclerosis
D006454:Hemoglobins; D002097:C-Reactive Protein; D007770:L-Lactate Dehydrogenase