title: Flavonoids: from cell cycle regulation to biotechnology.
abstract: Flavonoids have been proposed to play diverse roles in plant growth and development, including defense, symbiosis, pollen development and male fertility, polar auxin transport, and protection against ultraviolet radiation. Recently, a new role in cell cycle regulation has emerged. Genetic alteration of glucuronide metabolism by altered expression of a Pisum sativum UDP-glucuronosyltransferase (PsUGT1) results in an altered cell cycle in pea, alfalfa, and Arabidopsis. In alfalfa, altered expression of PsUGT1 results in accumulation of a flavonoid-like compound that suppresses growth of cultured cells. The results are consistent with the hypothesis that PsUGT1 functions by controlling cellular levels of a factor controlling cell cycle (FCC).
authors.affiliation: Department of Plant Sciences, Division of Plant Pathology and Microbiology, University of Arizona, Tucson, AZ 85721, USA. hhwoo@email.arizona.edu
authors.forename: Ho-Hyung
authors.initials: HH
authors.lastname: Woo
authors.forename: Byeong Ryong
authors.initials: BR
authors.lastname: Jeong
authors.forename: Martha C
authors.initials: MC
authors.lastname: Hawes
mesh_terms: D001709:Biotechnology / Q000379:methods* / Q000639:trends; D002453:Cell Cycle / Q000502:physiology*; D049109:Cell Proliferation; D005419:Flavonoids / Q000378:metabolism* / Q000494:pharmacology*; D007210:Indoleacetic Acids / Q000378:metabolism; D000455:Medicago sativa / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy; D010944:Plants / Q000378:metabolism*; D030821:Plants, Genetically Modified; D011058:Pollen; D013559:Symbiosis
chemical_list: D005419:Flavonoids; D007210:Indoleacetic Acids