title: Disseminated thrombosis-induced growth plate necrosis in rat: a unique model for growth plate arrest.
abstract: Exposure of rats to 2-butoxyethanol (BE) produces early hemolytic anemia and disseminated thrombosis. This leads to infarctions in multiple organs, including bones and cartilage. BE, administered for different durations of exposure in two separate experiments, produced metaphyseal vascular thrombosis, growth plate infarction, and partial or complete physeal growth arrest. This reproducible model may serve as a useful tool in the study of some conditions that manifest growth plate damage. The suitability of this model for investigating the pathogenesis of growth plate necrosis and as a model for potential therapy for various human growth plate disorders are discussed.
authors.affiliation: Department of Orthopaedic Surgery, Sapir Medical Center, 48 Tchernichovsky Street, Kfar-Saba 44281, Israel. nyska@internet-zahav.net
authors.forename: Meir
authors.initials: M
authors.lastname: Nyska
authors.forename: Shay
authors.initials: S
authors.lastname: Shabat
authors.forename: Philip H
authors.initials: PH
authors.lastname: Long
authors.forename: Charles
authors.initials: C
authors.lastname: Howard
authors.forename: Nathan
authors.initials: N
authors.lastname: Ezov
authors.forename: Tal
authors.initials: T
authors.lastname: Levin-Harrus
authors.forename: Moshe
authors.initials: M
authors.lastname: Mittelman
authors.forename: Meir
authors.initials: M
authors.lastname: Redlich
authors.forename: Saul
authors.initials: S
authors.lastname: Yedgar
authors.forename: Abraham
authors.initials: A
authors.lastname: Nyska
mesh_terms: D000818:Animals; D001848:Bone Diseases, Developmental / Q000139:chemically induced / Q000503:physiopathology*; D005026:Ethylene Glycols / Q000009:adverse effects; D005260:Female; D006132:Growth Plate / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D023421:Models, Animal; D009336:Necrosis / Q000139:chemically induced; D051381:Rats; D012997:Solvents / Q000009:adverse effects; D013927:Thrombosis / Q000139:chemically induced*
chemical_list: D005026:Ethylene Glycols; D012997:Solvents; C017096:n-butoxyethanol