[Study on laser flash spectroscopy of laser-induced interaction of DNA and polynucleotides with SO4*-].
The interactions of DNA and polynucleotides (poly[G],poly[A] and poly[C]) with SO4*- were investigated by 248 nm laser flash photolysis. The results show that, the reactions of poly[G] or poly[A] with SO4*- yield predominantly the corresponding one-electron-oxidated base radicals. With poly[C], it is suggested that SO4*- radical reacts predominantly by addition to the base moiety to produce C5-yl and C6-yl sulphate radical adducts,and subsequently H-abstraction yields C2'-sugar radical. The predominant species resulting from the reaction of DNA with SO4*- is DNA guanyl radical.
Song
Q
Q
Department of Chemical Physics, University of Science and Technology of China, 230026 Hefei.
LI
Q
Q
Xu
Y
Y
Dai
J
J
Yu
S
S
Chen
C
C
Ma
X
X
Lin
W
W
Yao
S
S
D004247:DNA / Q000737:chemistry*; D004249:DNA Damage / Q000528:radiation effects*; D007834:Lasers; D010782:Photolysis / Q000528:radiation effects*; D011119:Polynucleotides / Q000737:chemistry*; D013057:Spectrum Analysis; D013431:Sulfates / Q000737:chemistry*
D011119:Polynucleotides; D013431:Sulfates; C069025:sulfate radical; D004247:DNA