title: Consecutive approach to alkenes that combines radical addition of phosphorus hydrides with Horner-Wadsworth-Emmons-type reactions.
abstract: [reaction: see text] Addition of diethyl thiophosphite to terminal alkenes, in the presence of a radical initiator, followed by deprotonation of the phosphonothioate and reaction with a ketone, offers a concise one-pot approach to substituted alkenes. This novel method, which can incorporate alkylation or acylation steps, can be applied to the stereoselective formation of sterically hindered tri- and tetrasubstituted alkenes.
authors.affiliation: Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK, and GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK.
authors.forename: Mark P
authors.initials: MP
authors.lastname: Healy
authors.forename: Andrew F
authors.initials: AF
authors.lastname: Parsons
authors.forename: James G T
authors.initials: JG
authors.lastname: Rawlinson