title: Effect over time of endotoxin adsorption therapy in sepsis.
abstract: Despite the use of potent antibiotics and intensive supportive care, the mortality among patients with sepsis and Gram-negative bacteremia remains high. In recent years, endotoxin adsorption therapy (PMX-DHP, polymyxin-direct hemoperfusion) has been widely used in Japan to remove endotoxin, a causative agent of sepsis. In septic patients whose clinical condition may change at any moment, the decision of when to perform blood purification in addition to conventional intensive care is a critical factor in the therapeutic strategy and prognosis. In the present study, we investigated the effect over time of PMX-DHP in sepsis. The subjects were 16 patients with systemic inflammatory response syndrome (SIRS) who required surgical treatment including a surgical operation and drainage. The following six parameters were compared between the first and second PMX-DHP: mean blood pressure and time-restricted urine at four time points - at baseline and at 6, 24 and 72 h after PMX-DHP; and white blood cell count, platelet count, base excess and Septic Severity Score (SSS) at 24 and 72 h after PMX-DHP. Mean blood pressure improved over time up to 24 h after both the first and second PMX-DHP. Time-restricted urine volume improved only at 6 h after the first PMX-DHP. White blood cell count improved over time up to 24 h after both the first and second PMX-DHP. The SSS improved at all time points studied except for 3 days after the second PMX-DHP. We conclude that PMX-DHP is expected to have important implications in terms of (i) correction of clinical conditions (by severity assessment); (ii) improvement of hemodynamics; (iii) possible anti-inflammatory effect; and (iv) possible improvement of oxygen metabolism in tissues.
authors.affiliation: Department of Surgery, Kitasato University School of Medicine, Kanagawa, Japan. tueno@partners.org
authors.forename: Takuya
authors.initials: T
authors.lastname: Ueno
authors.forename: Michio
authors.initials: M
authors.lastname: Sugino
authors.forename: Hiromu
authors.initials: H
authors.lastname: Nemoto
authors.forename: Hisataka
authors.initials: H
authors.lastname: Shoji
authors.forename: Akira
authors.initials: A
authors.lastname: Kakita
authors.forename: Masahiko
authors.initials: M
authors.lastname: Watanabe
mesh_terms: D018806:APACHE; D000327:Adsorption; D000368:Aged; D000369:Aged, 80 and over; D004731:Endotoxins / Q000097:blood* / Q000302:isolation & purification / Q000652:urine; D005260:Female; D006439:Hemodynamics; D006464:Hemoperfusion / Q000379:methods; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D004731:Endotoxins