title: Botox therapy for refractory chronic migraine.
abstract: Chronic migraine is unfortunately both common and often resistant to treatment even with prophylactic medications known to be effective in populations with episodic migraine. We undertook an open-label study to evaluate the safety and utility of botulinum toxin type A injection therapy for patients with chronic migraine who previously had failed to respond to at least three prophylactic medications.
authors.affiliation: University of South Alabama Headache Center, Mobile, AL 36693, USA.
authors.forename: Stafford
authors.initials: S
authors.lastname: Conway
authors.forename: Curtis
authors.initials: C
authors.lastname: Delplanche
authors.forename: Jessica
authors.initials: J
authors.lastname: Crowder
authors.forename: John
authors.initials: J
authors.lastname: Rothrock
mesh_terms: D000328:Adult; D000368:Aged; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy* / Q000517:prevention & control; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D017211:Treatment Failure
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A