New members of the insulin family: regulators of metabolism, growth and now ... reproduction.
Insulin, IGF, and relaxin are established members of the insulin protein superfamily. The application of the techniques of cellular, molecular, and computational biology has permitted the identification of new insulin-like ligands and their cognate receptors. Information regarding the biologic role is available for some of these newly identified ligand-receptor systems and indicates novel roles in diverse processes such as testicular descent, germ cell function, and cell migration.
Lu
Chunxia
C
Department of Pediatrics, C.S. Mott Children's Hospital, University of Michigan Medical School, Ann Arbor 48109, USA.
Lam
Hien N
HN
Menon
Ram K
RK
D000818:Animals; D002465:Cell Movement; D005260:Female; D005854:Germ Cells / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000235:genetics / Q000502:physiology*; D008024:Ligands; D008297:Male; D010802:Phylogeny; D011506:Proteins / Q000502:physiology; D012098:Reproduction; D015398:Signal Transduction; D013737:Testis / Q000033:anatomy & histology
D007328:Insulin; C084797:Leydig insulin-like protein; D008024:Ligands; D011506:Proteins