title: Alveolar bone necrosis and tooth exfoliation following herpes zoster infection: a review of the literature and case report.
abstract: BACKGROUND
  Herpes zoster (HZ) presents as a cutaneous vesicular eruption in the area innervated by the affected sensory nerve, usually associated with severe pain. Oral manifestations of HZ appear when the mandibular or maxillary divisions of the trigeminal nerve are affected.
  
  
  METHODS
  This is a case report of a 63-year-old woman with HZ infection with trigeminal nerve involvement that led to a rapid loss of alveolar bone and exfoliation of two teeth.
  
  
  RESULTS
  The initial intraoral examination showed redness of the alveolar mucosa and gingiva of the lower right quadrant with multiple well-delimited and painful erosive lesions affecting the attached gingiva around the teeth. Two weeks later, teeth number 27 (lower right canine) and 28 (lower right first premolar) had class III mobility, flow of purulent exudate from the gingival sulcus, and deep pockets (>11 mm). The radiological examination showed advanced alveolar bone loss around both teeth. The prognosis for teeth number 27 and 28 was considered hopeless, and they were extracted. Due to extensive necrosis there was no interdental alveolar bone. The case is presented with a review of clinical data from patients with trigeminal HZ infection associated with osteonecrosis or exfoliation of teeth previously reported in the literature. The mechanisms by which the HZ infection leads to the alveolar bone necrosis are discussed.
  
  
  CONCLUSIONS
  Extensive osteonecrosis and exfoliation of teeth in the area innervated by the nerve affected by HZ has been reported after HZ infection. Clinicians should be aware of this possible outcome after a trigeminal HZ infection.
authors.affiliation: Dental Faculty, University of Barcelona, Barcelona, Spain. cmendieta@ub.edu
authors.forename: C
authors.initials: C
authors.lastname: Mendieta
authors.forename: J
authors.initials: J
authors.lastname: Miranda
authors.forename: L I
authors.initials: LI
authors.lastname: Brunet
authors.forename: J
authors.initials: J
authors.lastname: Gargallo
authors.forename: L
authors.initials: L
authors.lastname: Berini
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D016301:Alveolar Bone Loss / Q000821:virology*; D000998:Antiviral Agents / Q000627:therapeutic use; D005260:Female; D006562:Herpes Zoster / Q000150:complications*; D014645:Herpesvirus 3, Human; D006801:Humans; D008336:Mandibular Diseases / Q000821:virology; D008875:Middle Aged; D010020:Osteonecrosis / Q000821:virology; D014080:Tooth Exfoliation / Q000821:virology*; D014276:Trigeminal Nerve / Q000821:virology
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir