[Effects of Naomaitai capsule on learning and memory and content of Ach in rat model produced by cerebral ischemia-reperfusion].
OBJECTIVE
To observe the effects of Naomaitai capsule on the learning and memory abilities and the content of acetylcholine(Ach) in the brain tissue of the model rat.


METHODS
One vascular dementia(VD) model was produced by occlusion of bilateral common carotid arteries in rats with following steps: ischemia 20 minutes-reperfusion 10 minutes-ischemia 20 minutes. The learning and memory abilities were tested by water maze. The other VD model was formed by 4-vessel occlusion-reperfusion injury in rats. The time of right reflect recovery and the content of Ach in the brain tissue were determined.


RESULTS
Naomaitai capsule can significantly improve the learning and memory abilities of the dementia rats( P < 0.05, P < 0.01), increase the content of Ach (P < 0.05, P < 0.01) and reduce the time of right reflect recovery(P < 0.01).


CONCLUSIONS
Naomaitai capsule can improve the learning and memory abilities by increasing the content of Ach of the VD rats.
Wang
Zheng
Z
Guilin Sanjin Pharmaceutical Company Limited, Guilin 541004, China.
Li
Yun-Man
YM
Gong
Xiao-Jian
XJ
Lin
Jun
J
Zou
Jie-Ming
JM
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001923:Brain Chemistry; D002545:Brain Ischemia / Q000378:metabolism; D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D020441:Ginkgo biloba / Q000737:chemistry; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000494:pharmacology; D005894:Panax / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000378:metabolism* / Q000523:psychology
D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D000109:Acetylcholine