Effects of acute and chronic oval exposure of lead on blood pressure and bone mineral density in rats.
The immediate and late deleterious effects of early lead (Pb) exposure on human health are major challenges to the health professionals. Therefore, a major underlying contribution of Pb accumulated earlier in life to chronic disorders such as hypertension and osteopenia, commonly found in the elderly, cannot be definitively excluded. Using Sprague-Dawley rats, we examined the effects of drinking 1% Pb acetate on very young rats for 40 days on Pb kinetics, body weight (BW), systolic blood pressure (SBP) and bone mineral density (BMD) over a year-long period. We also examined the effects of early and later chelation using disodium calcium ethylenediaminetetraacetate (Na2CaEDTA). The early ingestion and accumulation of Pb was associated with an increased SBP acutely that returned to control levels with continuing challenge and later rose above control months later after the Pb challenge had been halted. Early accumulation of Pb over a short period was also associated with decreased BMD at the end of one year. Chelation after the initial Pb challenge at various times favorably influenced the SBP but could not prevent the lowering of BMD.
Bagchi
Debasis
D
Department of Pharmacy Sciences, Creighton University Medical Center, Omaha, NE 68178, USA. debsis@creighton.edu
Preuss
Harry G
HG
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight; D015519:Bone Density / Q000187:drug effects*; D002614:Chelating Agents / Q000378:metabolism; D004492:Edetic Acid / Q000378:metabolism; D004781:Environmental Exposure; D006801:Humans; D007854:Lead / Q000032:analysis / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D013997:Time Factors
D002614:Chelating Agents; D007854:Lead; D004492:Edetic Acid