title: Synthesis and antimycobacterial activity of ferrocenyl ethambutol analogues and ferrocenyl diamines.
abstract: A new series of ferrocenyl diamino alcohols and diamines were synthesized and their inhibitory potencies were probed with Mycobacterium tuberculosis. Interestingly, ferrocenyl diamines 6a and b display significant activities against M. tuberculosis H37Rv.
authors.affiliation: Laboratoire de Chimie Appliquée aux Substances Naturelles, Faculté des Sciences d'Antananarivo, B.P. 906, 101 Antananarivo, Madagascar.
authors.forename: Dorothée
authors.initials: D
authors.lastname: Razafimahefa
authors.forename: Dimby Andrianina
authors.initials: DA
authors.lastname: Ralambomanana
authors.forename: Lies
authors.initials: L
authors.lastname: Hammouche
authors.forename: Lydie
authors.initials: L
authors.lastname: Pélinski
authors.forename: Sylvia
authors.initials: S
authors.lastname: Lauvagie
authors.forename: Christiane
authors.initials: C
authors.lastname: Bebear
authors.forename: Jacques
authors.initials: J
authors.lastname: Brocard
authors.forename: Jeanne
authors.initials: J
authors.lastname: Maugein
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D003959:Diamines / Q000138:chemical synthesis / Q000494:pharmacology; D004977:Ethambutol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D005296:Ferrous Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000995:Antitubercular Agents; D003959:Diamines; D005296:Ferrous Compounds; D004977:Ethambutol