title: Methyl bromide intoxication causes reversible symmetric brainstem and cerebellar MRI lesions.
abstract: Methyl bromide is toxic to the central and peripheral nervous systems. A patient with occupational exposure to this agent is described. MRI showed strikingly symmetric brainstem and cerebellar lesions. The patient's clinical course and the topography and resolution of his MRI abnormalities suggest that this condition is an energy deprivation syndrome.
authors.affiliation: Department of Neurology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA. geyer@doctor.com
authors.forename: Howard L
authors.initials: HL
authors.lastname: Geyer
authors.forename: Herbert H
authors.initials: HH
authors.lastname: Schaumburg
authors.forename: Steven
authors.initials: S
authors.lastname: Herskovitz
mesh_terms: D000328:Adult; D001928:Brain Diseases, Metabolic / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D001933:Brain Stem / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D002526:Cerebellar Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D002531:Cerebellum / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology; D020234:Gait Ataxia / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D006842:Hydrocarbons, Brominated / Q000506:poisoning*; D008279:Magnetic Resonance Imaging; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D016273:Occupational Exposure / Q000009:adverse effects; D015835:Ocular Motility Disorders / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology; D010292:Paresthesia / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology; D010525:Peripheral Nerves / Q000187:drug effects / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology; D020127:Recovery of Function; D012008:Recurrence; D014717:Vertigo / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology
chemical_list: D006842:Hydrocarbons, Brominated; C005218:methyl bromide