title: Effect of anti-tuberculosis therapy on liver function of pulmonary tuberculosis patients infected with hepatitis B virus.
abstract: OBJECTIVE
  To observe the effect of anti-tuberculosis therapy on liver function of pulmonary tuberculosis patients with hepatitis B virus (HBV) infection, and to compare the differences of liver function by two treatments of anti-tuberculosis.
  
  
  METHODS
  Forty-seven TB patients with HBV infection and 170 TB patients without HBV infection were divided into HPBE(S) and HLAMKO treatment groups. Liver function tests before and after the treatments were performed once in 2 wk or monthly, and their clinical manifestations were recorded.
  
  
  RESULTS
  The rate of hepatotoxicity occurred in 26 (59%) TB patients with HBV during anti-TB treatment, higher than that in 40 (24%) TB patients without HBV. Hepatotoxicity occurred in 66 out of 217 patients, and the incidence of liver dysfunction was 46.1% in HPBE(S) group, significantly higher than that in HLAMKO group (12.7%) (P<0.01).
  
  
  CONCLUSIONS
  TB patients with HBV should choose HLAMKO treatment because of fewer hepatotoxicity.
authors.affiliation: Center of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, Shaanxi Province, China. panlei0225@sina.com
authors.forename: Lei
authors.initials: L
authors.lastname: Pan
authors.forename: Zhan-Sheng
authors.initials: ZS
authors.lastname: Jia
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
authors.forename: En-Qing
authors.initials: EQ
authors.lastname: Fu
authors.forename: Guang-Yu
authors.initials: GY
authors.lastname: Li
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008099:Liver / Q000187:drug effects* / Q000502:physiology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D014397:Tuberculosis, Pulmonary / Q000150:complications* / Q000188:drug therapy* / Q000453:epidemiology
chemical_list: D000995:Antitubercular Agents