title: Macromolecular recognition.
abstract: Computational methods are being developed both to detect the binding surfaces of individual macromolecules and to predict the structure of binary macromolecular complexes. Speeding up and refining this process has required work on search algorithms, molecular representations and interaction potentials. Although backbone flexibility and solvent effects continue to pose problems, encouraging results have been obtained for both protein-protein and protein-DNA complexes.
authors.affiliation: Laboratoire de Biochimie Théorique (CNRS UPR 9080), Institut de Biologie Physico-Chimique, 13 rue Pierre et Marie Curie, Paris 75005, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Deremble
authors.forename: Richard
authors.initials: R
authors.lastname: Lavery
mesh_terms: D000465:Algorithms; D001665:Binding Sites; D003198:Computer Simulation; D004247:DNA / Q000032:analysis / Q000737:chemistry*; D004268:DNA-Binding Proteins / Q000032:analysis / Q000737:chemistry; D046911:Macromolecular Substances / Q000032:analysis / Q000737:chemistry*; D008956:Models, Chemical; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011485:Protein Binding; D011487:Protein Conformation; D025941:Protein Interaction Mapping / Q000379:methods*; D011506:Proteins / Q000032:analysis / Q000737:chemistry*; D017421:Sequence Analysis / Q000379:methods; D013329:Structure-Activity Relationship
chemical_list: D004268:DNA-Binding Proteins; D046911:Macromolecular Substances; D011506:Proteins; D004247:DNA