Application of bis-acetylenic ketones in synthesis: one-pot preparation of the 1,2,4-triazepine and oxatriazaindenone cores.
Bis-acetylenic ketones were used to generate two heterocyclic templates. Two efficient one-pot procedures for the preparation of the triazepine and oxa-triazaindenone cores are described.
Adamo
Mauro F A
MF
Centre for Synthesis and Chemical Biology (CSCB), Department of Pharmaceutical and Medicinal Chemistry, The Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Dublin, Ireland. madamo@rcsi.ie
Baldwin
Jack E
JE
Adlington
Robert M
RM
D000480:Alkynes / Q000138:chemical synthesis / Q000737:chemistry*; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D001381:Azepines / Q000138:chemical synthesis*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D007192:Indenes / Q000138:chemical synthesis*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure
D000480:Alkynes; D001372:Aza Compounds; D001381:Azepines; D006571:Heterocyclic Compounds; D007192:Indenes; D007659:Ketones