Molecular mechanisms of West Nile virus pathogenesis in brain cell.
We analyzed the response of human glioma cells to West Nile virus infection by investigating host transcriptional changes. Changes in expression of 23 genes showed similarities to those in other neurodegenerative diseases. These changes may be useful as potential biomarkers and elucidate novel mechanisms behind the neuropathology of infection with this virus.
Koh
Wee-Lee
WL
National University of Singapore, Singapore.
Ng
Mah-Lee
ML
D015415:Biomarkers; D001921:Brain / Q000821:virology*; D045744:Cell Line, Tumor; D003588:Cytopathogenic Effect, Viral; D015870:Gene Expression; D005909:Glioblastoma; D006801:Humans; D046228:Microarray Analysis; D015203:Reproducibility of Results; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014901:West Nile Fever / Q000503:physiopathology; D014902:West Nile virus / Q000472:pathogenicity*
D015415:Biomarkers