[Clinical observation on effect of weichangshu in treating diabetic gastroparesis].
OBJECTIVE
To observe the effect of Weichangshu (WCS) in treating diabetic gastroparesis (DGP).


METHODS
Ninety-six patients with DGP were randomly divided into two groups. Besides the same conventional blood glucose controlling regimen was given to both groups, WSC was given to the treated group and Mosapride Citrate tablet to the control group additionally. The treatment course for them was 4 weeks. Therapeutic effect on clinical syndromes was assessed, the fasting and 2-hr postprandial blood glucose, antro-duodenal interdigestive migrating motor complex (MMC) and electrogastrogram (EGG) were measured before and after treatment.


RESULTS
The therapeutic effect in the two groups were similar with no statistical significant difference. The time of MMC phase II was shortened, time of MMC phase III prolonged, and the constriction amplitude of which increased after treatment in both groups, showing significant difference as compared to those before treatment (P < 0.05). EGG were significantly changed after treatment mainly manifested as increase of proportional dominant frequency (PDF) and strengthening of proportional dominant amplitude (PDP ) (P <0.05 or P < 0.01). Besides, WSC also promoted the decrease of post-prandial blood glucose.


CONCLUSIONS
WSC has dual effect in promoting gastric motility and decreasing blood glucose, with less adoerst reaction.
Zhong
Yi
Y
Institute of Piwei Research, Guangzhou University of TCM, Guangzhou. zhongyisir@21cn.com
Zhou
Hong
H
Zhong
Ling
L
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004576:Electromyography / Q000187:drug effects; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D005769:Gastrointestinal Motility / Q000187:drug effects; D018589:Gastroparesis / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy
D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D005765:Gastrointestinal Agents