title: Statins and autoimmune diseases.
abstract: Inhibitors of 3-hydroxy-3methylglytaryl coenzyme A (HMG-CoA) reductase or statins are effective lipid lowering drugs widely used in cardiovascular disease. In the recent years, pleotropic effects of statins have been reported, which include anti-inflammatory and immunomodulatory properties. This review discusses the anti-inflammatory and immunomodulatory roles of statins and their possible use for the treatment of other inflammatory diseases or conditions with the involvement of the immune system.
authors.affiliation: Mechnicov's State Medical Academy, The Center of Atherosclerosis and Lipid Disorders, Tel-Hashomer, Israel.
authors.forename: Victor S
authors.initials: VS
authors.lastname: Gurevich
authors.forename: Ora
authors.initials: O
authors.lastname: Shovman
authors.forename: Liat
authors.initials: L
authors.lastname: Slutzky
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Meroni
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Shoenfeld
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors