"Tethered" Ru(II) catalysts for asymmetric transfer hydrogenation of ketones.
Stereochemically well-defined ruthenium(II) catalysts have been applied to the asymmetric transfer hydrogenation of a series of ketones. In one case, statistical experimental design was employed to optimize the enantiomeric excess of the product. In the case of the TsDPEN-based systems, the replacement of trans-1,2-diphenyl substitution with cis-, or deletion of one of the phenyl groups, results in significant deterioration of the enantiomeric excess. A new method is described for the synthesis of tethered amino alcohol-containing catalysts.
Cheung
Fung Kei Kathy
FK
Department of Chemistry, University of Warwick, Coventry, CV4 7AL, United Kingdom.
Hayes
Aidan M
AM
Hannedouche
Jerome
J
Yim
Aveline S Y
AS
Wills
Martin
M