title: Immunization with recombinant surface antigen P50 of Babesia gibsoni expressed in insect cells induced parasite growth inhibition in dogs.
abstract: This is a report of a vaccine trial directed against Babesia gibsoni infection in dogs with the use of the recombinant antigen P50. Dogs immunized with P50 showed partial protection manifested as a significantly low level of parasitemia. The results indicated that P50 is a primary vaccine candidate molecule against canine B. gibsoni infection.
authors.affiliation: National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Fukumoto
authors.forename: Yoh
authors.initials: Y
authors.lastname: Tamaki
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Shirafuji
authors.forename: Shinji
authors.initials: S
authors.lastname: Harakawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Suzuki
authors.forename: Xuenan
authors.initials: X
authors.lastname: Xuan
mesh_terms: D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology* / Q000627:therapeutic use; D000954:Antigens, Surface / Q000276:immunology; D001403:Babesia / Q000276:immunology; D001404:Babesiosis / Q000276:immunology / Q000517:prevention & control* / Q000662:veterinary; D015153:Blotting, Western / Q000379:methods; D002478:Cells, Cultured; D004283:Dog Diseases / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D007114:Immunization / Q000379:methods*; D007313:Insecta / Q000166:cytology / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000276:immunology / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D000953:Antigens, Protozoan; D000954:Antigens, Surface; D011993:Recombinant Fusion Proteins