title: Myopia progression is specified by a double exponential growth function.
abstract: OBJECTIVE
  The purpose of this study was to demonstrate how well a modified Gompertz double exponential growth function delineates the diverse courses of myopia progression found in individual eyes. The function is: R = Re + Rc(0.07295)(a(x - t0)) where the spherical equivalent refractive error at a given age R equals the initial refractive error (Re) plus the overall refractive change (Rc) times a double exponential function with the base (0.07295) representing the proportion of Rc that occurs when maximum acceleration is reached, a is a curvature coefficient, t0 is the age of onset and x is age.
  
  
  METHODS
  This function was fit to longitudinal refractive data (spherical equivalents) for both eyes of 36 myopic children. The fits were required to meet a stringent set of criteria, including fitting transitions in and out of myopia progression and having no systematic errors or arbitrary constants.
  
  
  RESULTS
  Correlation between values on the refractive function and corresponding data of individual eyes is high (mean r = 0.973 +/- 0.020), the sum of squares between the data and function is low, and all other criteria are met. The rates of refractive change and acceleration were derivable from this function. It has been shown that, if peak acceleration rate is used as a criterion for the onset of myopia progression, then myopization onset starts a year earlier (mean = 8.93 years) than when a -0.50-D onset criterion is used (mean = 9.93 years), and it usually starts before the spherical equivalent reaches zero (mean R = +0.09 D). Age of onset is highly correlated with the duration of myopia progression (r = 0.693), which in turn is correlated with the amount of myopia achieved (r = 0.443).
  
  
  CONCLUSIONS
  We demonstrate that the double exponential function delineates the dynamics of myopia progression onset, offset, and the derivatives that describe the mechanisms underlying the growth process that causes myopia and have explained the advantages of this function. The function can be used to more accurately portray the course of individual subject's myopic progression.
authors.affiliation: Myopia Research Center, New England College of Optometry, Boston, Massachusetts 02115, USA. thornf@ne-optometry.edu
authors.forename: Frank
authors.initials: F
authors.lastname: Thorn
authors.forename: Jane
authors.initials: J
authors.lastname: Gwiazda
authors.forename: Richard
authors.initials: R
authors.lastname: Held
mesh_terms: D000293:Adolescent; D000328:Adult; D002675:Child, Preschool; D018450:Disease Progression; D006801:Humans; D008954:Models, Biological; D009216:Myopia / Q000503:physiopathology*; D012029:Refraction, Ocular