title: A new antibiotic, antimycin Ag, produced by Streptomyces sp. K01-0031.
abstract: A new antimycin group antibiotic, antimycin A9, was isolated from a cultured broth of Streptomyces sp. K01-0031 together with antimycins A3a, A3b, A4, and A7, and flazin methyl ester. Antimycin A9 is the first antimycin having an aromatic 8-acyl residue. It showed potent nematocidal and insecticidal activities against Caenorhabditis elegans and Artemia salina, respectively. It inhibited bovine heart NADH oxidase at nanomolar level like other known antimycins.
authors.affiliation: School of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo 108-8641, Japan. shiomik@pharm.kitasato-u.ac.jp
authors.forename: Kazuro
authors.initials: K
authors.lastname: Shiomi
authors.forename: Kenji
authors.initials: K
authors.lastname: Hatae
authors.forename: Hiroko
authors.initials: H
authors.lastname: Hatano
authors.forename: Atsuko
authors.initials: A
authors.lastname: Matsumoto
authors.forename: Yoko
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Cheng-Lin
authors.initials: CL
authors.lastname: Jiang
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tomoda
authors.forename: Susumu
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Haruo
authors.initials: H
authors.lastname: Tanaka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Omura
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000968:Antimycin A / Q000031:analogs & derivatives* / Q000302:isolation & purification* / Q000494:pharmacology; D000969:Antinematodal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects; D017173:Caenorhabditis elegans / Q000187:drug effects; D002417:Cattle; D008826:Microbial Sensitivity Tests; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors; D013302:Streptomyces; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000969:Antinematodal Agents; D009097:Multienzyme Complexes; C499974:antimycin A9; D000968:Antimycin A; C023107:NADH oxidase; D009247:NADH, NADPH Oxidoreductases