title: Conditioned inhibition of cocaine seeking in rats.
abstract: Despite its potential relevance to the treatment of drug abuse, conditioned inhibition of drug seeking has not been systematically investigated before. In this study, rats could self-administer cocaine by lever pressing whenever a click or tone was present. Responding was not reinforced when a light was present. The light was presented simultaneously with the click (i.e., in an excitatory context) in 1 group, but the light was always presented alone in another group. When it was later presented in compound with the tone, the light was a highly effective conditioned inhibitor, suppressing cocaine seeking by 92% in the former group and by 74% in the latter. These results suggest ways to improve cue-oriented behavioral treatments for drug abuse.
authors.affiliation: Department of Psychology, American University, Washington, DC 20016, USA. dk0085a@american.edu
authors.forename: David N
authors.initials: DN
authors.lastname: Kearns
authors.forename: Stanley J
authors.initials: SJ
authors.lastname: Weiss
authors.forename: Charles W
authors.initials: CW
authors.lastname: Schindler
authors.forename: Leigh V
authors.initials: LV
authors.lastname: Panlilio
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D003042:Cocaine; D003213:Conditioning, Psychological; D003463:Cues; D005106:Exploratory Behavior; D008297:Male; D009433:Neural Inhibition / Q000502:physiology*; D051381:Rats; D020318:Rats, Long-Evans; D012054:Reinforcement, Psychology
chemical_list: D003042:Cocaine