Serum cholesterol and testicular cancer incidence in 45,000 men followed for 25 years.
In a 25-year follow-up study of 44,864 men with measured serum cholesterol levels, the testicular cancer hazard ratios for the serum cholesterol categories 5.7-6.9 and > or = 7.0 mmol l(-1) vs the reference category (<5.7 mmol l(-1)) were 1.3 and 4.5, respectively; P-value for trend=0.005. This highly significant association suggests that high-serum cholesterol is a risk factor for testicular cancer.
Wiréhn
A-B
AB
Department of Health and Society, Linköping University, SE-581 83 Linköping, Sweden. annwi@ihs.liu.se
Törnberg
S
S
Carstensen
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood*; D015331:Cohort Studies; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012307:Risk Factors; D013736:Testicular Neoplasms / Q000453:epidemiology*
D002784:Cholesterol