title: Influence of 516G>T polymorphisms at the gene encoding the CYP450-2B6 isoenzyme on efavirenz plasma concentrations in HIV-infected subjects.
abstract: We examined 516G>T polymorphisms at the gene encoding the cytochrome P450 in 100 human immunodeficiency virus-positive subjects who were receiving efavirenz (EFV). Elevated plasma EFV concentrations were found in 40% of subjects with the polymorphic homozygous genotype and 19% of subjects with the heterozygous genotype. Conversely, 20% of subjects with the wild-type genotype had subtherapeutic concentrations of EFV. CYP2B6-516 genotyping may help to identify subjects who have plasma EFV concentrations that are outside of the therapeutic range.
authors.affiliation: Pharmacokinetic Unit, Hospital Carlos III, Madrid, Spain.
authors.forename: Sonia
authors.initials: S
authors.lastname: Rodriguez-Novoa
authors.forename: Pablo
authors.initials: P
authors.lastname: Barreiro
authors.forename: Ana
authors.initials: A
authors.lastname: Rendón
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Jiménez-Nacher
authors.forename: Juan
authors.initials: J
authors.lastname: González-Lahoz
authors.forename: Vincent
authors.initials: V
authors.lastname: Soriano
mesh_terms: D000328:Adult; D000480:Alkynes; D048588:Benzoxazines; D003521:Cyclopropanes; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy* / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010078:Oxazines / Q000009:adverse effects / Q000097:blood* / Q000493:pharmacokinetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D000480:Alkynes; D048588:Benzoxazines; D003521:Cyclopropanes; D007527:Isoenzymes; D010078:Oxazines; D003577:Cytochrome P-450 Enzyme System; C098320:efavirenz