SV40 enhances the risk of malignant mesothelioma among people exposed to asbestos: a molecular epidemiologic case-control study.
We conducted a case-control study on asbestos exposure and presence of SV40 in tumor samples of malignant mesotheliomas (MMs) and bladder urotheliomas (BUs). PCR analysis revealed the presence of SV40 DNA (SV40+) in eight (42.1%) MMs and 6 (33.3%) BUs. The odds ratio for MM Asb- and SV40+ was 0.4 [95% confidence interval (95% CI), 0.03-4.0], for Asb+ and SV40- was 3.6 (95% CI, 0.6-21.0), and for Asb+ and SV40+ was 12.6 (95% CI, 1.2-133.9). Our results suggest that SV40 increases the risk of MM among individuals exposed to asbestos.
Cristaudo
Alfonso
A
Department of Endocrinology and Metabolism, Orthopedic and Traumatology, Occupational Medicine, University of Pisa, 56100 Pisa, Italy. a.cristaudo@med.unipi.it
Foddis
Rudy
R
Vivaldi
Agnese
A
Buselli
Rodolfo
R
Gattini
Vittorio
V
Guglielmi
Giovanni
G
Cosentino
Francesca
F
Ottenga
Franco
F
Ciancia
Eugenio
E
Libener
Roberta
R
Filiberti
Rosangela
R
Neri
Monica
M
Betta
Piergiacomo
P
Tognon
Mauro
M
Mutti
Luciano
L
Puntoni
Riccardo
R
D000368:Aged; D001194:Asbestos / Q000506:poisoning*; D016022:Case-Control Studies; D003043:Cocarcinogenesis; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics / Q000821:virology; D017720:Molecular Epidemiology; D016133:Polymerase Chain Reaction; D027601:Polyomavirus Infections / Q000150:complications* / Q000821:virology; D013539:Simian virus 40 / Q000235:genetics / Q000502:physiology*; D014412:Tumor Virus Infections / Q000150:complications* / Q000821:virology; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000235:genetics / Q000821:virology
D004273:DNA, Neoplasm; D001194:Asbestos