title: Antineoplastic agents 470. Absolute configuration of the marine sponge bromopyrrole agelastatin A.
abstract: Two bromopyrrole marine alkaloids were isolated from the Mexican sponge, Agelas sp.: hymenidin (1) and agelastatin A (2). The structures were elucidated by analysis of their spectroscopic data and found to correspond to those in the literature. The absolute configuration of agelastatin A (2) was elucidated by single-crystal X-ray diffraction methods. Agelastatin A (2) exhibited strong activity against a panel of human cancer cell lines as well as human umbilical vein endothelial cells.
authors.affiliation: Cancer Research Institute, Department of Chemistry and Biochemistry, Arizona State University, P.O. Box 872404, Tempe, AZ 85287-2404, USA. bpettit@asu.edu
authors.forename: George R
authors.initials: GR
authors.lastname: Pettit
authors.forename: Sylvie
authors.initials: S
authors.lastname: Ducki
authors.forename: Delbert L
authors.initials: DL
authors.lastname: Herald
authors.forename: Dennis L
authors.initials: DL
authors.lastname: Doubek
authors.forename: Jean M
authors.initials: JM
authors.lastname: Schmidt
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Chapuis
mesh_terms: D000470:Alkaloids; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry; D008968:Molecular Conformation; D023303:Oxazolidinones; D011161:Porifera / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D023303:Oxazolidinones; D011758:Pyrroles; C464968:agelastatin A; C050529:hymenidin