title: "Sugar" tumor of the pancreas: a rare entity that is diagnosable on preoperative fine-needle biopsies.
abstract: This study is the second to report a pancreatic "sugar" tumor (ST) case. This ST was incidentally discovered in a 31-year-old woman using computed tomography scan (CT scan) for work-up of a hepatic focal nodular hyperplasia. Both CT scan and endoluminal ultrasonography (EUS) features evoked a 15-mm large benign endocrine tumor. Pathological examination of EUS-guided fine-needle aspiration biopsies could not confirm this diagnosis. Laparoscopic corporeo-caudal pancreatectomy was performed. The tumor was intrapancreatic, well circumscribed, and organized in sheets of epithelioid cells. The tumor cells expressed HMB-45 but did not express epithelial or endocrine immunohistochemical markers. These histophenotypic features are those of an extra pulmonary ST, which belong to the PEComa family of tumors. Retrospective examination of preoperative biopsies evidenced the same histophenotypic features. This observation highlights that STs should be considered in preoperative differential diagnosis of pancreas tumors, since they may be treated by limited surgical resection.
authors.affiliation: Department of Pathology, Institut Paoli-Calmettes, Marseille, France. ramuzo@marseille.fnclcc.fr
authors.forename: Olivier
authors.initials: O
authors.lastname: Ramuz
authors.forename: Bernard
authors.initials: B
authors.lastname: Lelong
authors.forename: Marc
authors.initials: M
authors.lastname: Giovannini
authors.forename: Jean-Robert
authors.initials: JR
authors.lastname: Delpero
authors.forename: Philippe
authors.initials: P
authors.lastname: Rochaix
authors.forename: Luc
authors.initials: L
authors.lastname: Xerri
authors.forename: Jacques
authors.initials: J
authors.lastname: Hassoun
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Flejou
authors.forename: Geneviève
authors.initials: G
authors.lastname: Monges
mesh_terms: D000328:Adult; D018207:Angiomyolipoma / Q000737:chemistry / Q000473:pathology / Q000601:surgery; D000951:Antigens, Neoplasm; D044963:Biopsy, Fine-Needle; D003937:Diagnosis, Differential; D005260:Female; D020518:Focal Nodular Hyperplasia / Q000150:complications; D006801:Humans; D010535:Laparoscopy; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins / Q000032:analysis; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D000951:Antigens, Neoplasm; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins