Spectral characteristics of the supramolecular complexes of polypyrrolic sensitizers and cyclodextrin carriers: usage in photodynamic therapy of tumors.
The objective of our work was to describe the photophysical properties (absorption and fluorescence) of the sensitizers TPPS4, ZnTPPS4 a PdTPPS4 and above all the complexes of these sensitizers with cyclodextrin carriers HP-alpha-CD, HP-beta-CD and HP-gamma-CD (2-hydroxypropyl-alpha, beta, gamma-cyclodextrin) in a suitable environment for the cultivation of cancerous cell lines, and to determine the optimal radioactive conditions for maximizing photodynamic effects in cancerous cells.
Huf
Martin
M
Palacky University Olomouc, Faculty of Medicine, Institute of Medical Biophysics, Czech Republic. m.huf@seznam.cz
Kolárová
Hana
H
Bajgar
Robert
R
Macecek
Jaroslav
J
Tomecka
Marek
M
Nevrelová
Pavla
P
Mosinger
Jirí
J
Tomek
Pavel
P
Strnad
Miroslav
M
D003505:Cyclodextrins / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy; D010777:Photochemistry; D010778:Photochemotherapy; D011108:Polymers / Q000737:chemistry; D011166:Porphyrins / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry; D011838:Radiation-Sensitizing Agents / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013053:Spectrophotometry
D003505:Cyclodextrins; D004337:Drug Carriers; D011108:Polymers; D011166:Porphyrins; D011758:Pyrroles; D011838:Radiation-Sensitizing Agents; C067635:polypyrrole