Cell cycle in mouse development.
Mice likely represent the most-studied mammalian organism, except for humans. Genetic engineering in embryonic stem cells has allowed derivation of mouse strains lacking particular cell cycle proteins. Analyses of these mutant mice, and cells derived from them, facilitated the studies of the functions of cell cycle apparatus at the organismal and cellular levels. In this review, we give some background about the cell cycle progression during mouse development. We next discuss some insights about in vivo functions of the cell cycle proteins, gleaned from mouse knockout experiments. Our text is meant to provide examples of the recent experiments, rather than to supply an extensive and complete list.
Ciemerych
Maria A
MA
Department of Embryology, Institute of Zoology, Faculty of Biology, Warsaw University, Miecznikowa 1, 02-096 Warsaw, Poland.
Sicinski
Peter
P
D000818:Animals; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000502:physiology; D047108:Embryonic Development / Q000502:physiology; D051379:Mice; D008817:Mice, Mutant Strains
D018797:Cell Cycle Proteins