title: The endothelin receptor antagonist decreases ischemia/reperfusion-induced tumor necrosis factor production in isolated rat hearts.
abstract: Previous studies have shown that endothelin-1 (ET-1) may play a pathophysiological role in myocardial ischemia/reperfusion injury. In the present study, BMS-182874 significantly improved the recovery of cardiac function and reduced the release of CK during reperfusion after ischemia and the content of tumor necrosis factor (TNF-alpha) in myocardial tissues. BMS-182874 also reduced myocardial injury and the increased level of TNF-alpha by exogenous ET-1. These results suggest that the cardioprotective effects of the ET receptor antagonist may be related to inhibition of TNF-alpha production.
authors.forename: Tian-Lun
authors.initials: TL
authors.lastname: Yang
authors.forename: Mei-Fang
authors.initials: MF
authors.lastname: Chen
authors.forename: Jun-Ling
authors.initials: JL
authors.lastname: Jiang
authors.forename: Qi-Ying
authors.initials: QY
authors.lastname: Xie
authors.forename: Yun-Ping
authors.initials: YP
authors.lastname: Li
authors.forename: Yuan-Jian
authors.initials: YJ
authors.lastname: Li
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D003619:Dansyl Compounds / Q000494:pharmacology*; D019332:Endothelin-1 / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D000959:Antihypertensive Agents; D003619:Dansyl Compounds; D019332:Endothelin-1; D014409:Tumor Necrosis Factor-alpha; C085754:5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide