Effects of cisplatin on olfactory function in cancer patients.
A prospective analysis of olfaction was performed in 21 patients receiving cisplatin. A reduction in olfactory function was noted in only one patient. Hearing impairment was documented in nine patients, none of whom had impaired sense of smell. We conclude that cisplatin has no major deleterious effect on olfactory function at doses which cause hearing impairment.
Yakirevitch
A
A
Department of Otolaryngology-Head and Neck Surgery, The Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel.
Talmi
Y P
YP
Baram
Y
Y
Weitzen
R
R
Pfeffer
M R
MR
D000328:Adult; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D034381:Hearing Loss / Q000139:chemically induced; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000188:drug therapy*; D000857:Olfaction Disorders / Q000139:chemically induced*
D002945:Cisplatin