Short-term effects of arsenic sulfur in deficits of contractile and relaxant responses on urinary bladder: pharmacological and structural changes.
BACKGROUND
Our goal was to investigate the effects of arsenic sulfur (AsS) on the detrusor smooth muscle reactivity.


METHODS
AsS (100 ppm microg/g) in drinking water was administered for 2 weeks to two groups of female Wistar rats. The contractile responses of urinary bladders to electrical field stimulation, carbachol, ATP and KCl, and the relaxant responses to ATP, adenosine and isoproterenol were examined. Urinary bladder strips were collected for light microscopic examination.


RESULTS
Our results demonstrate that oral inorganic AsS exposure induced enhanced contractile and reduced relaxant responses in rats. We hypothesize that AsS is involved in deficiencies of isolated urinary bladder in rats.


CONCLUSIONS
These functional and morphological changes may be important as an intermediate link in urinary bladder oncogenesis induced by AsS.
Gür
Serap
S
Department of Pharmacology, College of Pharmacy, Ankara University, Ankara, Turkey. sgur@pharmacy.ankara.edu.tr
Dogan
A Umran
AU
Dogan
Meral
M
Karahan
S Tuna
ST
Can
Belgin
B
Hafez
Gaye
G
Ozgunes
Ozan
O
Kendirci
Muammer
M
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001152:Arsenicals / Q000494:pharmacology*; D002217:Carbachol / Q000494:pharmacology; D018679:Cholinergic Agonists / Q000494:pharmacology; D004558:Electric Stimulation; D005260:Female; D009119:Muscle Contraction / Q000187:drug effects* / Q000502:physiology; D009126:Muscle Relaxation / Q000187:drug effects* / Q000502:physiology; D009130:Muscle, Smooth / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013440:Sulfides / Q000494:pharmacology*; D001743:Urinary Bladder / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D019459:Urothelium / Q000166:cytology / Q000187:drug effects
D001152:Arsenicals; D018679:Cholinergic Agonists; D013440:Sulfides; C045816:arsenic trisulfide; D011189:Potassium Chloride; D000255:Adenosine Triphosphate; D002217:Carbachol