Disseminated thrombosis-induced growth plate necrosis in rat: a unique model for growth plate arrest.
Exposure of rats to 2-butoxyethanol (BE) produces early hemolytic anemia and disseminated thrombosis. This leads to infarctions in multiple organs, including bones and cartilage. BE, administered for different durations of exposure in two separate experiments, produced metaphyseal vascular thrombosis, growth plate infarction, and partial or complete physeal growth arrest. This reproducible model may serve as a useful tool in the study of some conditions that manifest growth plate damage. The suitability of this model for investigating the pathogenesis of growth plate necrosis and as a model for potential therapy for various human growth plate disorders are discussed.
Nyska
Meir
M
Department of Orthopaedic Surgery, Sapir Medical Center, 48 Tchernichovsky Street, Kfar-Saba 44281, Israel. nyska@internet-zahav.net
Shabat
Shay
S
Long
Philip H
PH
Howard
Charles
C
Ezov
Nathan
N
Levin-Harrus
Tal
T
Mittelman
Moshe
M
Redlich
Meir
M
Yedgar
Saul
S
Nyska
Abraham
A
D000818:Animals; D001848:Bone Diseases, Developmental / Q000139:chemically induced / Q000503:physiopathology*; D005026:Ethylene Glycols / Q000009:adverse effects; D005260:Female; D006132:Growth Plate / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D023421:Models, Animal; D009336:Necrosis / Q000139:chemically induced; D051381:Rats; D012997:Solvents / Q000009:adverse effects; D013927:Thrombosis / Q000139:chemically induced*
D005026:Ethylene Glycols; D012997:Solvents; C017096:n-butoxyethanol