title: Plasticizer di(2-ethylhexyl)phthalate (DEHP) release in wet-primed extracorporeal membrane oxygenation (ECMO) circuits.
abstract: A wet-primed ready-to-use extracorporeal membrane oxygenation (ECMO) circuit is used in some centres for rapid deployment of ECMO during cardiopulmonary resuscitation. Yet, the potential release of plasticizer di(2-ethylhexyl)phthalate (DEHP) from the polyvinyl chloride tubing in the circuit during storage is a concern. In this study, a high performance liquid chromatography method was used to determine the concentration of DEHP in the priming solution (Plasmalyte) from an ECMO circuit stored for up to 14 days at 8 degrees C. No accumulation of DEHP in the circulating fluid was detected. The results provide important information for centres where ECMO circuits are kept wet-primed prior to clinical use.
authors.affiliation: Centre for Paediatric Pharmacy Research, School of Pharmacy, University of London, 29/39 Brunswick Square, London WC1N 1AX, UK.
authors.forename: Jihong
authors.initials: J
authors.lastname: Han
authors.forename: Allison
authors.initials: A
authors.lastname: Beeton
authors.forename: Paul
authors.initials: P
authors.lastname: Long
authors.forename: Ann
authors.initials: A
authors.lastname: Karimova
authors.forename: Alex
authors.initials: A
authors.lastname: Robertson
authors.forename: Nigel
authors.initials: N
authors.lastname: Cross
authors.forename: Liz
authors.initials: L
authors.lastname: Smith
authors.forename: Maura
authors.initials: M
authors.lastname: O'Callaghan
authors.forename: Allan
authors.initials: A
authors.lastname: Goldman
authors.forename: Kate
authors.initials: K
authors.lastname: Brown
authors.forename: Catherine
authors.initials: C
authors.lastname: Tuleu
mesh_terms: D004051:Diethylhexyl Phthalate / Q000032:analysis* / Q000378:metabolism; D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects / Q000379:methods*; D010968:Plasticizers / Q000032:analysis* / Q000378:metabolism
chemical_list: D010968:Plasticizers; D004051:Diethylhexyl Phthalate