title: Hypolipidemic activity of aqueous extract of Capparis spinosa L. in normal and diabetic rats.
abstract: The purpose of this study was to examine the effect of single and repeated oral administrations of the aqueous extract of Capparis spinosa L. (CS) at a dose of 20mg/kg on lipid metabolism in normal and streptozotocin-induced diabetic rats. In normal rats, the aqueous extract of CS induced a significant decrease on plasma triglycerides concentrations 1 week (p<0.05) and 2 weeks (p<0.01) after once daily repeated oral administration. A significant decrease of plasma cholesterol levels was also observed 4 days (p<0.05) and 1 week (p<0.05) after repeated oral administration. In diabetic rats, CS treatment caused a significant decrease of plasma triglycerides levels after repeated oral administration. Four days after repeated oral administration of aqueous CS extract, the plasma cholesterol levels were significantly decreased (p<0.05) and still dropped after 2 weeks (p<0.01). On the other hand, the repeated oral administration of CS aqueous extract caused a significant decrease of body weight 4 days after repeated oral treatment in diabetic rats (p<0.05). We conclude that the aqueous extract of CS (20 mg/kg) exhibits a potent lipid lowering activity in both normal and severe hyperglycemic rats after repeated oral administration of CS aqueous extract.
authors.affiliation: UFR PNPE, B.P. 21, Boutalamine, Errachidia 52000, Morocco. m.eddouks@caramail.com
authors.forename: M
authors.initials: M
authors.lastname: Eddouks
authors.forename: A
authors.initials: A
authors.lastname: Lemhadri
authors.forename: J-B
authors.initials: JB
authors.lastname: Michel
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D031484:Capparis; D002784:Cholesterol / Q000097:blood*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood*
chemical_list: D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol