[The effect of matrine on the expression of P170 LRP and TOPO II of obtained multi-drug resistance of mouse S180's tumour cell].
OBJECTIVE
To observe the effect of matrine on P170 expressed by multi-drug resistance gene, lung resistant protein (LRP), and boposomeras II.


METHODS
By the method of less dosage of chemotherapy PFC, the mouse model of multi-drug resistance of S180 tumour cell was set up. At the same time, matrine was administered to the mouse model for 4 weeks, and then P170 LRP, TOPO II were observed by flow cytometry.


RESULTS
Martine can obviously reduce the express of P170, LRP and the activity of TOPO II in multi-drug resistance tumour cell induced by chemotherapy.


CONCLUSIONS
Matrine can intervene the occurrence of the multi-drug resitance of tumor cells induced by chemotherapy.
Sun
Fujun
F
Shandong Acadmy of Chinese Medicine, Jinan.
Wang
Ning
N
Li
Guihai
G
Wang
Xuerong
X
Li
Xiaojing
X
Yin
Geping
G
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000096:biosynthesis* / Q000235:genetics; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D004250:DNA Topoisomerases, Type II / Q000096:biosynthesis* / Q000235:genetics; D018432:Drug Resistance, Multiple / Q000187:drug effects*; D051379:Mice; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D011807:Quinolizines; D012510:Sarcoma 180 / Q000378:metabolism* / Q000473:pathology; D020394:Vault Ribonucleoprotein Particles / Q000235:genetics / Q000378:metabolism*; D000093842:Matrines; D000099187:Major Vault Protein
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D004250:DNA Topoisomerases, Type II; D009363:Neoplasm Proteins; D011807:Quinolizines; D020394:Vault Ribonucleoprotein Particles; D000093842:Matrines; D000099187:Major Vault Protein