Epigenetic reprogramming throughout preimplantation development and consequences for assisted reproductive technologies.
Knowledge about preimplantation development is important both for basic reproductive biology and for practical applications, including livestock breeding and regenerative medicine. During preimplantation development, epigenetic modifications such as DNA methylation and histone modifications are involved in the regulation of imprinted and non-imprinted genes, in the initiation of X chromosome inactivation, and the adjustment of telomere length. The underlying events are particularly vulnerable to external factors. Characterization of expression profiles in in vivo-derived embryos of different developmental stages and understanding the mechanisms and dynamics underlying the reprogramming process are the first steps towards the analysis of the complex gene regulatory networks. They provide a baseline for the analysis of manipulated embryos of all mammalian species, including humans, to improve embryo technologies and related therapeutic applications.
Wrenzycki
Christine
C
Institute for Animal Breeding, Department of Biotechnology, Mariensee, Neustadt, Germany. Wrenzycki@tzv.fal.de
Herrmann
Doris
D
Lucas-Hahn
Andrea
A
Gebert
Claudia
C
Korsawe
Karin
K
Lemme
Erika
E
Carnwath
Joseph W
JW
Niemann
Heiner
H
D000818:Animals; D019175:DNA Methylation; D010064:Embryo Implantation / Q000502:physiology*; D044127:Epigenesis, Genetic; D006801:Humans; D027724:Reproductive Techniques, Assisted