Depth-resolved low-coherence enhanced backscattering.
The phenomenon of enhanced backscattering (also known as coherent backscattering), an object of substantial scientific interest, has awaited application to tissue optics for the past two decades. Here we demonstrate, for the first time to our knowledge, depth-resolved spectroscopic elastic light scattering measurements in tissue by use of low-coherence enhanced backscattering (LEBS). We achieve the depth resolution by exploiting the nature of the LEBS peak that contains information about a wide range of tissue depths. We further demonstrate that depth-resolved LEBS spectroscopy has the potential to identify the origin of precancerous transformations in the colon at an early, previously undetectable stage.
Kim
Young L
YL
Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA. younglae@northwestern.edu
Liu
Yang
Y
Turzhitsky
Vladimir M
VM
Wali
Ramesh K
RK
Roy
Hemant K
HK
Backman
Vadim
V
D000236:Adenoma / Q000473:pathology*; D000818:Animals; D003110:Colonic Neoplasms / Q000473:pathology*; D007089:Image Enhancement / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008027:Light; D008297:Male; D019047:Phantoms, Imaging; D011230:Precancerous Conditions / Q000473:pathology*; D051381:Rats; D011916:Rats, Inbred F344; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000379:methods*