[Laboratory-immunology indicators according as prognostic factors of patients with colon and rectum cancer].
BACKGROUND
The occurrence of colon and rectum cancers has risen gradually in the past twenty years. In order to make a precise forecast about a patient's life expectancy and/or treatment, the factors of prognosis and outlook are used in oncology. These can be classified as clinical-surgical, pathological-histological and laboratory-immunology.


OBJECTIVE
To establish the significance of the laboratory-immunology indicators, carcino-embryonic antigen (CEA), proliferate nuclear antigen (PCNA) as well as Ki67 and p53 in the survival rate of patients who have colon or rectum cancer.


METHODS
In "Sveti Vracevi" Hospital in Bijeljina 33 patients suffering from cancer of the left half of the colon and rectum received treatment from 1st January 2000 to 1st January 2003. They all had immunohistochemical analysis of CEA, PCNA, Ki67 and p53.


RESULTS
The patients with positive immunohistochemical CEA, PCNA and p53 values had statistically shorter life expectancy in comparison with the patients with negative CEA, PCNA and p53 values. There was not statistically significant difference in the survival rate of patients with positive immunohistochemical Ki67 values in relation to the patients with the negative values.


CONCLUSIONS
Immunohistochemical analysis is not used in the routine analysis of colon and rectum cancers. Establishing them gives enough information on the patient's survival rate.
Maksimović
Sinisa
S
Opsta bolnica Sveti Vracevi u Bijeljini, Bosna i Hercegovina. sinisam@rstel.net
D014408:Biomarkers, Tumor / Q000032:analysis; D015179:Colorectal Neoplasms / Q000175:diagnosis*; D006801:Humans; D007150:Immunohistochemistry; D011379:Prognosis
D014408:Biomarkers, Tumor