[Epilepsy and pregnancy: antiepileptic drugs effects on pregnancy].
OBJECTIVE
The aim of our study was to analyse the antiepileptic drugs (AEDs) usage in pregnant women with epilepsy, and to evaluate possible complications of this therapy during pregnancy and delivery as well as fetal effects of there drugs.


METHODS
This retrospective study was conducted in the University Hospital Center Rijeka, Croatia, during the ten-year period (Jan 1, 1993-Dec 31, 2002). The study included 151 pregnant women with epilepsy. Data were entered in a structured form for evaluation of patient general data and data on antiepileptic therapy and neonatal outcome according to the use of AEDs.


RESULTS
During the study period, 185 children (male 95) were born. Twenty-four miscarriages were recorded in women with the diagnosis of epilepsy in their medical history. In 117 of women, the onset of epilepsy occurred before the age of 20 years. AEDs were used in 111 of patients, in 77% of them as monotherapy. The most frequently used AEDs were carbamazepine (36.2%), valproate (29.3%), phenobarbitone (24.1%). Folic acid was used in 25 pregnancies only, however, during 2002 folic acid was used in 15 pregnancies (yielding 22 in total). Apgar score was equal or higher than 8/8 in 96% of children. No specific teratogenic effects were observed.


CONCLUSIONS
Study results showed standard AEDs to be most commonly used in the study population, entailing no major birth defects, thus the potential risk probably being rather low. In the study population of pregnant women with epilepsy, the use of folic acid improved in 2002 in comparison to the previous period.
Sepić-Grahovac
Dubravka
D
Medicinski fakultet Sveucilista u Rijeci, Rijeka, Hrvatska.
Vitezić
Dinko
D
Petrović
Oleg
O
Willheim
Ksenija
K
Jurjević
Ante
A
Sindik
Nebojsa
N
D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*
D000927:Anticonvulsants