title: Personality traits and heart rate variability predict long-term cardiac mortality after myocardial infarction.
abstract: OBJECTIVE
  To investigate personality traits and sympatho-vagal modulation of heart rate variability (HRV) during acute myocardial infarction (AMI), assessing their relationships and their long-term prognostic value.
  
  
  RESULTS
  Psychological traits and 24 h HRV were prospectively investigated in 246 patients at discharge of an AMI. Patients were followed-up to 8 years for the occurrence of cardiac death and non-fatal reinfarction. Low coping and anxiety traits associated with reduced HRV characterized the study population. At univariate analysis, low emotional sensitivity and insecurity, relative tachycardia, reduced high frequency (HF), and low frequency power and pNN50 were predictive of cardiac death at 8-year follow-up. At multivariable analysis, low emotional sensitivity and low HF power remained predictive, with a relative risk of 4.18 (P=0.003) and 2.76 (P=0.007), respectively; also the type of infarction (Q vs. non-Q) and hospital length of stay were independent predictive variables.
  
  
  CONCLUSIONS
  Anxiety and emotional sensitivity were significant predictors of 8-year cardiac mortality after AMI. Reduced HF power, a recognized marker of vagal withdrawal, increased the risk.
authors.affiliation: CNR Institute of Clinical Physiology, Via G. Moruzzi 1, 56124 Pisa, Italy. clara@ifc.cnr.it
authors.forename: Clara
authors.initials: C
authors.lastname: Carpeggiani
authors.forename: Michele
authors.initials: M
authors.lastname: Emdin
authors.forename: Franco
authors.initials: F
authors.lastname: Bonaguidi
authors.forename: Patrizia
authors.initials: P
authors.lastname: Landi
authors.forename: Claudio
authors.initials: C
authors.lastname: Michelassi
authors.forename: Maria Giovanna
authors.initials: MG
authors.lastname: Trivella
authors.forename: Alberto
authors.initials: A
authors.lastname: Macerata
authors.forename: Antonio
authors.initials: A
authors.lastname: L'Abbate
mesh_terms: D000342:Affective Symptoms / Q000150:complications; D001008:Anxiety Disorders / Q000150:complications; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate / Q000502:physiology*; D006760:Hospitalization; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000401:mortality* / Q000523:psychology*; D010551:Personality; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity