title: Effect of leukocyte-depleted blood cardioplegia on the early outcome in patients with preserved left ventricular function undergoing surgical revascularisation.
abstract: BACKGROUND
  It has been shown that leukocytes play one of the key roles in the myocardial reperfusion injury.
  
  
  OBJECTIVE
  To examine the effects of cardiac protection with leukocyte-depleted blood cardioplegia on the early outcome of patients with preserved left ventricular function who undergo surgical revascularisation.
  
  
  METHODS
  The study group consisted of 58 patients with coronary artery disease (CAD) undergoing coronary artery bypass grafting (CABG) who were randomised to receive leukocyte-depleted blood cardioplegia (leukocyte filter Pall BC1B) (group A, n=29) or to receive standard blood cardioplegia (group B, n=29). Peri-operative mortality and morbidity as well as haemodynamical and biochemical parameters were compared between these two groups.
  
  
  RESULTS
  No early death occurred. There were no statistical differences in clinical data between the groups. Only cardiac index measured 24 hours after declamping of aorta was significantly higher in group A than in group B (3.6+/-0.6 l/min/m(2) vs 2.95+/-0.45 l/min/m(2), p<0.05). Group B showed significant higher release of creatine kinase (CK) 6 and 12 hours, and CK-MB 6, 12, and 24 hours after unclumping the aorta whereas troponin I level was similar in both groups.
  
  
  CONCLUSIONS
  The use of leukocyte-depleted blood cardioplegia during elective CABG did not improve the early outcome.
authors.affiliation: Department of Cardiac Surgery, Białystok, Poland.
authors.forename: Bronisław
authors.initials: B
authors.lastname: Czech
authors.forename: Marek
authors.initials: M
authors.lastname: Frank
authors.forename: Ewa
authors.initials: E
authors.lastname: Kucewicz
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Szapiel
authors.forename: Ryszard
authors.initials: R
authors.lastname: Jackowski
authors.forename: Alicja
authors.initials: A
authors.lastname: Gabrylewska
authors.forename: Jolanta
authors.initials: J
authors.lastname: Busłowska
mesh_terms: D000368:Aged; D002314:Cardioplegic Solutions / Q000008:administration & dosage; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000601:surgery*; D004311:Double-Blind Method; D005260:Female; D006324:Heart Arrest, Induced / Q000009:adverse effects* / Q000379:methods*; D006801:Humans; D047589:Leukocyte Reduction Procedures / Q000379:methods; D008297:Male; D008875:Middle Aged; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology* / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D002314:Cardioplegic Solutions