title: Spontaneously hypertensive rats left ventricular cardiomyocyte loss attenuation through different edible oils long-term intake.
abstract: BACKGROUND
  Dietary lipid intake type affecting spontaneously hypertensive rats (SHR) blood pressure (BP). There are no information available whether different edible lipids long-term administration does potentiality alter the usual cardiomyocyte loss in SHR or not.
  
  
  METHODS
  Six groups of 3-month-old male SHR received different edible oils (fish, canola, palm, olive, and soybean oils-1.5 g/kg/day+1 UI of vitamin E per ml) or water (control) by gavage for 13 weeks. Left ventricular cardiomyocyte number (N[cmn]) was analysed through stereology and disector method.
  
  
  RESULTS
  BP showed lower in the experimental groups (30% in the fish oil group, 15% in both canola oil and palm oil groups, 5% in both olive oil and soybean oil groups) when compared to the control group. N[cmn] was greater in the fish oil group and smaller in the control group. N[cmn] was over 130% greater in the fish oil group, and more than 25% greater in the canola, palm, and olive oils groups compared to the control group. N[cmn] showed a negative correlation with BP (R=-0.98, p<0.01).
  
  
  CONCLUSIONS
  Hypertension nutritional management and subsequent prevention/attenuation of left ventricular cardiomyocyte loss pointed out a novel therapeutic strategy to be seriously considered in the long-term hypertension treatment. The goal is to postpone the consequences of cardiomyocyte number decrease and heart failure in hypertension.
authors.affiliation: Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Brazil.
authors.forename: Marcia B
authors.initials: MB
authors.lastname: Aguila
authors.forename: Alessandra R
authors.initials: AR
authors.lastname: Pinheiro
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Mandarim-de-Lacerda
mesh_terms: D000818:Animals; D001699:Biometry; D004041:Dietary Fats / Q000494:pharmacology*; D005229:Fatty Acids, Monounsaturated / Q000494:pharmacology; D005395:Fish Oils / Q000494:pharmacology; D006973:Hypertension / Q000473:pathology / Q000628:therapy*; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D032383:Myocytes, Cardiac / Q000473:pathology*; D000069463:Olive Oil; D000073878:Palm Oil; D010938:Plant Oils / Q000494:pharmacology*; D000074262:Rapeseed Oil; D051381:Rats; D011918:Rats, Inbred SHR; D013024:Soybean Oil / Q000494:pharmacology
chemical_list: D004041:Dietary Fats; D005229:Fatty Acids, Monounsaturated; D005395:Fish Oils; D000069463:Olive Oil; D010938:Plant Oils; D000074262:Rapeseed Oil; D000073878:Palm Oil; D013024:Soybean Oil