The role of immune reconstitution inflammatory syndrome in AIDS-related Cryptococcus neoformans disease in the era of highly active antiretroviral therapy.
This study of human immunodeficiency virus (HIV)-infected patients coinfected with Cryptococcus neoformans found that 30% of patients who initiated highly active antiretroviral therapy developed immune reconstitution inflammatory syndrome (IRIS). Patients with C. neoformans-related IRIS had higher cerebrospinal fluid opening pressures, glucose levels, and white blood cell counts, compared with patients with typical HIV-associated C. neoformans meningitis.
Shelburne
Samuel A
SA
Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA. samuels@bcm.tmc.edu
Darcourt
Jorge
J
White
A Clinton
AC
Greenberg
Stephen B
SB
Hamill
Richard J
RJ
Atmar
Robert L
RL
Visnegarwala
Fehmida
F
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D019380:Anti-HIV Agents / Q000009:adverse effects; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D003453:Cryptococcosis / Q000209:etiology*; D006801:Humans; D007249:Inflammation / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology*; D012008:Recurrence
D019380:Anti-HIV Agents