[Long-term morphofunctional changes in the skin of Chernobyl clean-up workers].
Musculocutaneous samples taken from 19 Chernobyl clean-up workers were morphofunctionally examined to trace the changes, which had happened in them under the lasting exposure to low doses of ionizing radiation. The analysis showed that the greatest changes had taken place in the epidermis in the form of thickening of corneal and cellular layers and inflammatory infiltration of lymphocytes provided with the productive panvasculitis in the majority of arterioles. It is supposed that after the long low-doce irradiation two forms of reactions developed in the skin: a defense reaction in the form of proliferative hyperkeratosis and an immunopathological reaction. The latter is a consequence of activation in the cellular layer of epidermis combined with the appearance of effector component of immune response, which stimulates the interaction of epidermal T-lymphocytes with the endothelial cells of derma vessels and systemic involving of blood vessels of microcircular blood stream.
Porovskiĭ
Ia V
IaV
Ryzhov
A I
AI
Tetenev
F F
FF
D000328:Adult; D047852:Chernobyl Nuclear Accident; D004307:Dose-Response Relationship, Radiation; D004730:Endothelium, Vascular / Q000473:pathology; D004817:Epidermis / Q000276:immunology / Q000473:pathology; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000473:pathology; D008875:Middle Aged; D016273:Occupational Exposure; D011832:Radiation Injuries / Q000276:immunology / Q000473:pathology*; D011839:Radiation, Ionizing; D018788:Radioactive Hazard Release; D012867:Skin / Q000098:blood supply / Q000473:pathology* / Q000528:radiation effects*; D013601:T-Lymphocytes / Q000276:immunology; D014657:Vasculitis / Q000276:immunology / Q000473:pathology