Coexistence of neurofibromatosis 1 and chiari type I malformation: an unusual association.
Neurofibromatosis 1 (NF-1) is a relatively common, autosomally dominant disorder, comprised of characteristic skin lesions. NF-1 is also associated with a variety of cerebral dysplasias. We describe a patient with both NF-1 and Chiari type I malformation. The frequency of this correlation depends on the magnetic resonance imaging (MRI) findings in patients with NF-1, because some cases of Chiari malformations are asymptomatic. Awareness and further observation of this unusual association are required, and Chiari type I malformation should be added to the differential diagnosis of the central nervous system dysplasias in patients affected by NF-1.
Hara
Hiroyuki
H
Department of Dermatology, Nihon University School of Medicine, Tokyo, Japan.
Arakawa
Hiroshi
H
D000328:Adult; D001139:Arnold-Chiari Malformation / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009456:Neurofibromatosis 1 / Q000150:complications / Q000175:diagnosis* / Q000473:pathology