title: Short-lasting impairment of temperature perception by high frequency rTMS of the sensorimotor cortex.
abstract: OBJECTIVE
  Repetitive transcranial magnetic stimulation (rTMS) has become a useful tool for investigating and even modulating human brain function. RTMS of the human motor cortex can produce changes in excitability that outlast the period of stimulation. To investigate the persistent effect of high-frequency rTMS of sensorimotor cortex (SM1) on somatosensory function.
  
  
  METHODS
  We evaluated the thermal thresholds (cold and warm sensation) in 14 normal subjects before and after a short train of 5Hz rTMS over the SM1 or occipital cortex (OC).
  
  
  RESULTS
  Threshold for cold perception was increased immediately after rTMS of the left SM1 and no effects at all were noticed after OC stimulation. There was a slight, not significant, increase of warm threshold immediately after the rTMS of the left SM1 and no effects at all were noticed after OC stimulation.
  
  
  CONCLUSIONS
  High frequency rTMS over primary sensorimotor cortex seems to modulate sensory function related to thermal (cold) perception.
  
  
  CONCLUSIONS
  The method may be useful for both the study of normal human physiology of temperature perception and for rTMS based manipulation of brain plasticity in patients with sensory disturbances.
authors.affiliation: FENNSI Group and Unidad Neurología Funcional, Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain. antonioo@sescam.jccm.es
authors.forename: A
authors.initials: A
authors.lastname: Oliviero
authors.forename: M Rubio
authors.initials: MR
authors.lastname: Esteban
authors.forename: F Sebastian
authors.initials: FS
authors.lastname: de la Cruz
authors.forename: L Fernádez
authors.initials: LF
authors.lastname: Cabredo
authors.forename: V
authors.initials: V
authors.lastname: Di Lazzaro
mesh_terms: D000328:Adult; D004558:Electric Stimulation / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006987:Hypesthesia / Q000209:etiology*; D008280:Magnetics; D008297:Male; D008875:Middle Aged; D010465:Perception / Q000502:physiology; D012684:Sensory Thresholds / Q000502:physiology; D013003:Somatosensory Cortex / Q000503:physiopathology*; D013696:Temperature