title: Stable remission after administration of rituximab in a patient with primary hepatic marginal zone B-cell lymphoma.
abstract: We describe a case of primary hepatic marginal zone B-cell lymphoma in a 36-year-old Caucasian male with a history of chronic hepatitis B infection. Immunohistochemically, extensive infiltration by a CD20-positive, CD5- negative and CD10-negative lymphoid cell population displaying a follicular arrangement was detected. Molecular analysis of immunoglobulin heavy chain gene rearrangements confirmed the clonal expansion of lymphoma cells. Fourteen months after surgical treatment, the tumour recurred in close proximity to the liver hilus, hampering further surgery. Therefore, we implemented a therapy using the monoclonal anti-CD20-antibody rituximab in a dose of 375 mg/m(2), administered four times once a week. Six, 10, 18, and 26 months later the recurrent lymphoma could no longer be detected as shown by abdominal ultrasonography and CT. This case report demonstrates the difficulties of treating this extremely rare liver disease and shows its response to rituximab therapy.
authors.affiliation: Department of Medicine B, University of Muenster, Muenster, Germany. gockelh@gmx.de
authors.forename: H R
authors.initials: HR
authors.lastname: Gockel
authors.forename: J
authors.initials: J
authors.lastname: Heidemann
authors.forename: A
authors.initials: A
authors.lastname: Lugering
authors.forename: R M
authors.initials: RM
authors.lastname: Mesters
authors.forename: R
authors.initials: R
authors.lastname: Parwaresch
authors.forename: W
authors.initials: W
authors.lastname: Domschke
authors.forename: N
authors.initials: N
authors.lastname: Lugering
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D008297:Male; D011859:Radiography; D000069283:Rituximab; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D000069283:Rituximab