An iron-catalysed chemo- and regioselective tetrahydrofuran synthesis.
An intermolecular ring expansion reaction of an aryl epoxide with several dienes, acrylates, enynes or styrenes under iron catalysis, generated tetrahydrofuran derivatives in a highly chemo- and regioselective fashion. The process could be used in an unprecedented way for the one step synthesis of racemic calyxolane A and calyxolane B with acceptable diastereoselectivity.
Hilt
Gerhard
G
Fachbereich Chemie, Philipps-Universitat Marburg, Hans-Meerwein-Strasse, 35043 Marburg, Germany. Hilt@chemie.uni-marburg.de
Bolze
Patrick
P
Kieltsch
Iris
I