title: Complement inhibiting properties of dragon's blood from Croton draco.
abstract: The latex of Croton draco, its extracts and several latex components have been investigated for their influence on both classical (CP) and alternative (AP) activation pathways of the complement system using a hemolytic assay. The best inhibition was found for the classical pathway. The latex, ethyl acetate and ethyl ether extracts exhibited extremely high inhibition on the CP (94, 90 and 77%, respectively) at a concentration of 1 mg/ml. The flavonoid myricitrin, the alkaloid taspine and the cyclopeptides P1 and P2 showed high inhibition on CP (83, 91, 78 and 63%, respectively) at a concentration of 0.9 mM.
authors.affiliation: Department of Biochemistry, Faculty of Biology, Sofia University, 1164 Sofia, Bulgaria.
authors.forename: Ivanka
authors.initials: I
authors.lastname: Tsacheva
authors.forename: Joerg
authors.initials: J
authors.lastname: Rostan
authors.forename: Tania
authors.initials: T
authors.lastname: Iossifova
authors.forename: Bernhard
authors.initials: B
authors.lastname: Vogler
authors.forename: Mariela
authors.initials: M
authors.lastname: Odjakova
authors.forename: Hernan
authors.initials: H
authors.lastname: Navas
authors.forename: Ivanka
authors.initials: I
authors.lastname: Kostova
authors.forename: Michaela
authors.initials: M
authors.lastname: Kojouharova
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kraus
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology; D000595:Amino Acid Sequence; D000818:Animals; D002392:Catechin / Q000302:isolation & purification / Q000494:pharmacology; D003167:Complement Activation / Q000187:drug effects*; D003169:Complement Inactivator Proteins / Q000302:isolation & purification* / Q000494:pharmacology; D029802:Croton / Q000737:chemistry*; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013552:Swine
chemical_list: D000470:Alkaloids; D003169:Complement Inactivator Proteins; D005419:Flavonoids; D010456:Peptides, Cyclic; D002392:Catechin; C018394:taspine