title: [Study on the NIR-Raman spectra and NIR-SERS spectra of amsacrine].
abstract: The near infrared surface-enhanced Raman spectra (NIR-SERS) of amsacrine,an anticancer agent, on silver collids were recored with high quality. The NIR-SERS enhancement factor is up to 10(4) magnitude. In comparison with the near infrared Raman (NIR-Raman) spectra of solid amsacrine, more information of vibrational structures of amsacrine molecules at low concentration and almost in its practical application envi ronment, can be given by the NIR-SERS. The enhancement mechanism is associated with the adsorption of acridyl ring and sulfonyl on silver surface.
authors.affiliation: National Center of Biomedical Analysis, Academy of Military Medical Sciences, 100850 Beijing.
authors.forename: H
authors.initials: H
authors.lastname: Tian
authors.forename: B
authors.initials: B
authors.lastname: Liu
authors.forename: Z
authors.initials: Z
authors.lastname: Song
authors.forename: S
authors.initials: S
authors.lastname: Shen
authors.forename: J
authors.initials: J
authors.lastname: Han
authors.forename: Y
authors.initials: Y
authors.lastname: Fang
mesh_terms: D000677:Amsacrine / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry*; D007259:Infrared Rays; D012834:Silver / Q000737:chemistry; D013059:Spectrum Analysis, Raman; D013499:Surface Properties
chemical_list: D000970:Antineoplastic Agents; D000677:Amsacrine; D012834:Silver