An old target revisited: two new privileged skeletons and an unexpected binding mode for HIV-protease inhibitors.
Specker
Edgar
E
Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marbacher Weg 6, 35032 Marburg, Germany.
Böttcher
Jark
J
Lilie
Hauke
H
Heine
Andreas
A
Schoop
Andreas
A
Müller
Gerhard
G
Griebenow
Nils
N
Klebe
Gerhard
G
D001665:Binding Sites; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry*; D006801:Humans; D006860:Hydrogen Bonding; D008958:Models, Molecular; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000138:chemical synthesis* / Q000737:chemistry*
D017320:HIV Protease Inhibitors; D013450:Sulfones