Convergent synthesis of a fully lipidated glycosylphosphatidylinositol anchor of Plasmodium falciparum.
A highly convergent strategy for the synthesis of fully lipidated GPI anchors of malarial origin is reported. This strategy utilized three orthogonal protecting groups, which can be chemoselectively deprotected and functionalized in the late stage of the synthesis. Rapid access to the target GPIs in a highly efficient manner in sufficient quantities for the biological studies has been achieved.
Liu
Xinyu
X
Laboratory for Organic Chemistry, ETH Zürich, Wolfgang-Pauli-Str. 10, HCI F315, 8093 Zürich, Switzerland.
Kwon
Yong-Uk
YU
Seeberger
Peter H
PH
D000818:Animals; D002240:Carbohydrate Sequence; D017261:Glycosylphosphatidylinositols / Q000138:chemical synthesis* / Q000737:chemistry; D008969:Molecular Sequence Data; D010963:Plasmodium falciparum / Q000378:metabolism*
D017261:Glycosylphosphatidylinositols