Proceedings of a consensus conference: towards an understanding of TRALI.
Transfusion-related acute lung injury is a relatively uncommon transfusion-associated adverse effect occurring during or soon after an allogeneic blood transfusion. Transfusion-related acute lung injury is a complex syndrome that has many manifestations and has only recently been identified to be an important cause of transfusion-associated morbidity and mortality. But despite its increasing recognition, much about the pathogenesis, treatment, and prevention is poorly understood and often controversial. The purpose of this consensus conference was to bring together international experts in an effort to try to standardize a case definition, which could be used to enhance future understanding of transfusion-related acute lung injury including its epidemiology, pathogenesis, management, prevention, and research. These proceedings are being provided with a view to making available to the transfusion medicine community the considerable amount of important information presented at this consensus conference by the invited international panel of experts.
Goldman
Mindy
M
Canadian Blood Services, Medical, Scientific and Research Affairs, Ottawa, Ontario K1G 4J5, Canada. mindy.goldman@bloodservices.ca
Webert
Kathryn E
KE
Arnold
Donald M
DM
Freedman
John
J
Hannon
Judith
J
Blajchman
Morris A
MA
D000328:Adult; D000368:Aged; D000818:Animals; D002170:Canada; D032921:Consensus; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D012128:Respiratory Distress Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D012307:Risk Factors; D013577:Syndrome; D013997:Time Factors; D065227:Transfusion Reaction; D014184:Transplantation, Homologous; D014481:United States