title: Prevention of recurrent radicular pain after lumbar disc surgery: a prospective study.
abstract: BACKGROUND
  Postoperative epidural fibrosis is a major causative factor of low-back pain even if microsurgical techniques are adopted to reduce this phenomenon. To prevent the recurrent radicular pain caused by this problem, we utilized adipose tissue drawn from the same patient; at the end of surgical procedure, the fat was placed around the spinal root or the dural sac. This procedure was evaluated by a prospective, randomised study.
  
  
  METHODS
  From 180 patients operated on for lumbar discectomy between January 2000 to December 2001, 74 were enclosed in the study. In 37 patients, the spinal root was covered by autologous fat (group A), in the other 37 (control group, B), this procedure was not adopted. One year after surgery, all the patients were evaluated with clinical and radiological (Magnetic Resonance Imaging) follow-up. Only two patients were lost to follow-up.
  
  
  RESULTS
  71% of the patients in group A had 100% of clinical and radiological post-operative outcome score; this result was obtained only in 35% of the patients in group B. A clinical score evaluating pain syndrome (from grade 0 to 5) and a radiological score evaluating postoperative fibrosis (from grade 0 to 4) was adopted. Therefore, group A had best outcome as compared to control group.
  
  
  CONCLUSIONS
  The authors found a positive effect in the reconstruction of epidural fat with autograft of adipose tissue to prevent postoperative scarring and failed-back syndrome related to postoperative fibrosis.
authors.affiliation: Service of Vertebral Microsurgery, Cristo Re Hospital, Messina, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Gambardella
authors.forename: O
authors.initials: O
authors.lastname: Gervasio
authors.forename: C
authors.initials: C
authors.lastname: Zaccone
authors.forename: E
authors.initials: E
authors.lastname: Puglisi
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D000293:Adolescent; D000328:Adult; D000368:Aged; D017586:Diskectomy / Q000009:adverse effects* / Q000379:methods*; D005260:Female; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D008159:Lumbar Vertebrae / Q000601:surgery*; D008297:Male; D008866:Microsurgery / Q000379:methods; D008875:Middle Aged; D010148:Intractable Pain / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D011843:Radiculopathy / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D055502:Secondary Prevention; D013126:Spinal Nerve Roots / Q000601:surgery; D016896:Treatment Outcome