Different anticancer effects of fluvastatin on primary hepatocellular tumors and metastases in rats.
Rats (FLF1) were pretreated with 2 and 20 mg/kg/day fluvastatin (Flu), and after 6 weeks, hepatocellular tumor cells were inoculated under the left renal capsule. At different times, growth and pyruvate kinase (PK) activity of the primary tumors and lymph node metastases were determined. Flu had a dose-dependent inhibitory effect on primary and metastatic tumors, and the inhibitory effect on growth and PK activity in metastases were higher than in primary tumors. Finally, Flu had an earlier inhibitory effect on the early appeared PK activity in metastases than in primary tumors.
Paragh
György
G
First Department of Medicine, University of Debrecen, P.O. Box 19, Debrecen H-4012, Hungary.
Fóris
Gabriella
G
Paragh
György
G
Seres
Ildikó
I
Karányi
Zsolt
Z
Fülöp
Péter
P
Balogh
Zoltán
Z
Kosztáczky
Béla
B
Teichmann
Farkas
F
Kertai
Pál
P
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000037:antagonists & inhibitors*; D005229:Fatty Acids, Monounsaturated / Q000627:therapeutic use*; D000077340:Fluvastatin; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D007211:Indoles / Q000627:therapeutic use*; D007668:Kidney; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D008207:Lymphatic Metastasis / Q000517:prevention & control; D008297:Male; D011770:Pyruvate Kinase / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D005229:Fatty Acids, Monounsaturated; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007211:Indoles; D000077340:Fluvastatin; D011770:Pyruvate Kinase