Analysis of loss of heterozygosity in Korean patients with keratoacanthoma.
Loss of heterozygosity (LOH) has been established as an important genetic mechanism giving rise to malignant neoplasia. The mechanism of LOH has been shown to cause basal cell carcinoma and malignant melanoma as well as other types of skin cancer. A few studies on LOH in sporadic keratoacanthomas have been reported. The purpose of this study was to investigate the significance of LOH in the pathogenesis of sporadic keratoacanthomas developed in 10 Korean patients. The presents of LOH at 7 microsatellite markers (D2S286, D3S1317, D5S346, D9S160, D9S171, D10S185, and D17S261) were evaluated in sporadic keratoacanthomas. LOH was found in only 1 of 10 cases at D10S185. The low frequency of LOH detected in this study suggests that LOH may not be significant in the induction of sporadic keratoacanthomas.
Ha
Tae-Won
TW
Department of Plastic and Reconstructive Surgery, Keimyung University School of Medicine, Daegu 700-712, Korea.
Han
Ki-Hwan
KH
Son
Dae-Gu
DG
Kim
Sang-Pyo
SP
Kim
Dae-Kwang
DK
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007636:Keratoacanthoma / Q000235:genetics*; D019656:Loss of Heterozygosity; D008297:Male; D008875:Middle Aged