title: [Study on pharmacokinetics of emodin in Rhizoma Polygontum Cuspidatum and its compound].
abstract: OBJECTIVE
  To study the difference in the pharmacokinetics of emodin in Zhiganning capsules and Rhizoma Polygontum Cuspidatum by nonaqueous RP-HPLC.
  
  
  METHODS
  The rats were orally administered with the extraction of Rhizoma Polygontum Cuspidatum and Zhiganning capsules. After hydrolysis and extraction, the content of emodin in the plasma is determined by Nonaqueous RP-HPLC.
  
  
  RESULTS
  The concentration-time profiles of emodin fit two-compartment model. The pharmacokinetics parameters including, t1/2alpha, AUC(0-infinity), CL(s) and C(max) of emodin in the group of Rhizoma Polygontum Cuspidatum were significantly different from these in the group of its compounds.
  
  
  CONCLUSIONS
  There is a significant difference in pharmacokinetics of emodin between zhiganning capsules and the extraction of Rhizoma Polygontum Cuspidatum.
authors.affiliation: Hebei Medical University, Shijiazhuang 050017, China.
authors.forename: Shu-Kun
authors.initials: SK
authors.lastname: Yao
authors.forename: Ye
authors.initials: Y
authors.lastname: Jiang
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Hao
authors.forename: Hong-Ju
authors.initials: HJ
authors.lastname: Liu
authors.forename: Shao-Hao
authors.initials: SH
authors.lastname: Jang
authors.forename: Wei-Na
authors.initials: WN
authors.lastname: Liu
mesh_terms: D000818:Animals; D019540:Area Under Curve; D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification; D004642:Emodin / Q000302:isolation & purification / Q000493:pharmacokinetics*; D005260:Female; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry*; D028502:Polygonum / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D027343:Rhizome / Q000737:chemistry
chemical_list: D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D004642:Emodin