Involvement of ICAM-1 in bone metabolism: a potential target in the treatment of bone diseases?
Bone diseases such as osteoporosis, osteoarthritis and rheumatoid arthritis (RA) affect a great proportion of individuals, with debilitating consequences in terms of pain and progressive limitation of function. Existing treatment of these pathologies has been unable to alter the natural evolution of the disease and, as such, a clearer understanding of the pathophysiology is necessary in order to generate new treatment alternatives. One therapeutic strategy could involve the targeting of intercellular adhesion molecule-1 (ICAM-1; CD54). In bone, ICAM-1 is expressed at the surface of osteoblasts (Obs) and its counter-receptor, leukocyte function-associated antigen-1 (LFA-1; CD11a), at the surface of osteoclast (Oc) precursors. ICAM-1 blockade between the Ob and the pre-Oc results in an inhibition of Oc recruitment and a modulation of inflammation, which could potentially help in controlling disease activity in bone pathologies. So far, clinical studies on ICAM-1 blockade in bone diseases have been limited to RA. A better understanding of the implication of this adhesion molecule in Ob/Oc interactions and inflammatory mediation in the bone pathological state, however, is needed. As new discoveries on the role of this adhesion molecule are being reported, ICAM-1 could become a potential target for other bone diseases as well.
Lavigne
Patrick
P
Hôpital du Sacré-Coeur de Montréal, Orthopedics Research Laboratory, Department of Orthopedics, 5400 boul. Gouin Ouest, Montréal, Québec, H4J 1C5, Canada.
Benderdour
Mohamed
M
Shi
Qin
Q
Lajeunesse
Daniel
D
Fernandes
Julio C
JC
D000818:Animals; D001847:Bone Diseases / Q000188:drug therapy / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*
D018799:Intercellular Adhesion Molecule-1