Long-term follow-up of lymphocyte populations and cellular cytokine production in patients with chronic graft-versus-host disease treated with extracorporeal photopheresis.
We studied lymphocyte populations and cytokine-expression profiles of ten patients with chronic graft-versus-host disease who at least transiently responded to photoimmunotherapy. The numbers of lymphocytes, monocytes and dendritic cells rose in most cases. Th1 cells always increased during therapy, supporting the hypothesis that a more favorable immune balance contributes to clinical responses.
Silva
Maria Gomes da
MG
Ferreira Neto
Lara
L
Guimarães
António
A
Machado
Alexandra
A
Parreira
António
A
Abecasis
Manuel
M
D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D016207:Cytokines / Q000096:biosynthesis*; D005260:Female; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*; D006801:Humans; D016131:Lymphocyte Subsets; D008297:Male; D008875:Middle Aged; D017893:Photopheresis; D018417:Th1 Cells / Q000737:chemistry; D018418:Th2 Cells / Q000737:chemistry
D016207:Cytokines