Probing metal-protein interactions using a de novo design approach.
De novo design of metalloproteins provides a valuable tool for understanding the structural constraints and functional attributes of natural biological systems using first principles. This review focuses on recent research aimed primarily at probing the subtle interactions between metals and proteins in designed systems. Considerable attention has focussed on redefining novel design methods used in mimicking natural hemeproteins, mononuclear and dinuclear metallopeptides and functional biological electron-transfer proteins. The present results indicate that the field of metalloprotein design is contributing significantly to the understanding of metals in biology.
Ghosh
Debdip
D
Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA.
Pecoraro
Vincent L
VL
D001665:Binding Sites; D008667:Metalloproteins / Q000138:chemical synthesis / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry*; D015202:Protein Engineering; D017510:Protein Folding
D008667:Metalloproteins; D008670:Metals; D010455:Peptides