Changes in central venous pressure with vasoactive drug injections in humans.
We tested whether central venous pressure (CVP) changes during vasoactive drug injections used for baroreflex assessment in humans. We measured CVP during sequential intravenous boluses of nitroprusside (NTP) and phenylephrine (PHE; modified Oxford technique). NTP caused a decrease in CVP of 1.9+/-0.2 mmHg from baseline (P<0.01) and PHE caused an increase in CVP of 0.3+/-0.2 mmHg above baseline. These changes in CVP may contribute to the observed integrated baroreflex responses.
Martin
Elizabeth A
EA
Dept. of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Rochester (MN) 55905, USA.
Charkoudian
Nisha
N
D000328:Adult; D017704:Baroreflex / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002496:Central Venous Pressure / Q000187:drug effects*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007267:Injections; D008297:Male; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology; D009599:Nitroprusside / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D010991:Plethysmography; D012039:Regional Blood Flow / Q000502:physiology; D012189:Retrospective Studies; D013564:Sympathetic Nervous System / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*
D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D009599:Nitroprusside; D010656:Phenylephrine