title: [Clinical pathology feature and prognostic factors of cervical lymph node metastases in hypopharyngeal carcinoma].
abstract: OBJECTIVE
  To investigate the risk clinicopathological factors of primary tumor in the prediction of cervical lymph node metastases and the cervical lymph node prognostic factors in hypopharyngeal squamous cell carcinoma.
  
  
  METHODS
  A retrospective study was carried out to review the histopathological data from 98 hypopharyngeal squamous cell carcinoma patients. The relationship between histopathological parameters and cervical lymph node metastases were evaluated by means of a univariate chi2 test and multivariate stepwise logistic regression model. And the Cox regression model was used to define possible pathological parameters of neck node affecting survival including N staging, presence of cervical lymph node metastases and extracapsular nodal spread, size and number of positive neck nodes, and levels of positive neck nodes.
  
  
  RESULTS
  The overall 5-year survival rate of patients with hypopharyngeal carcinoma was 28.6%. In a univariate and multivariate analysis, it was confirmed that size and growth pattern of primary tumor correlated to cervical lymph node metastases. In a multivariate Cox regression analysis, the most significant prognostic factors of cervical lymph node were the size of positive neck nodes and level involved.
  
  
  CONCLUSIONS
  Cervical lymph node metastases were one of the most significant prognostic factors of hypopharyngeal carcinoma. The identification of patients at risk for cervical lymph node metastases and the management of the neck by coping with pathological factors of cervical lymph node affecting survival are very important to improve the treatment and prognosis of hypopharyngeal carcinoma.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Bethune International Peace Hospital, Shijiazhuang 050082, China. xml_968@sohu.com
authors.forename: Xiao-min
authors.initials: XM
authors.lastname: Li
authors.forename: Bin
authors.initials: B
authors.lastname: Di
authors.forename: Yong-liang
authors.initials: YL
authors.lastname: Shao
authors.forename: Ji-min
authors.initials: JM
authors.lastname: Cheng
authors.forename: Hong-min
authors.initials: HM
authors.lastname: Ma
authors.forename: Chun-mei
authors.initials: CM
authors.lastname: Gao
authors.forename: Yao-dong
authors.initials: YD
authors.lastname: Shang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000175:diagnosis / Q000556:secondary*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018307:Neoplasms, Squamous Cell / Q000175:diagnosis / Q000556:secondary*; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies