Inhibitory effects of Okbyungpoong-Gamhmi on anaphylactic responses.
We investigated the effect of a herbal formulation Okbyungpoong-Gamhmi (OG) on mast cell-dependent anaphylactic reactions by intra-rectal administration. OG concentration dependently inhibited compound 48/80-induced anaphylaxis-like response and ear swelling response with doses of 0.01-1g/kg. OG also inhibited the passive cutaneous anaphylaxis at the same concentrations. The histamine release induced by compound 48/80 or IgE from the rat peritoneal mast cells was reduced by 64.2 and 63.6%, respectively, at 1g/l. These results provide evidence that intra-rectal therapy of OG may be beneficial in the treatment of anaphylactic response.
Hong
Seung-Heon
SH
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea.
Yi
Jin-Mu
JM
Kim
Hongjun
H
Choi
Ho-Young
HY
Kim
Yun-Kyung
YK
Chae
Han-Jung
HJ
Kim
Hyung-Ryong
HR
Kim
Cheorl-Ho
CH
Kim
Hyung-Min
HM
D000707:Anaphylaxis / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D007723:Korea; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D008519:Medicine, Traditional; D051379:Mice; D008813:Mice, Inbred ICR; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D008517:Phytotherapy / Q000379:methods*; D028321:Plant Preparations / Q000302:isolation & purification / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D003189:p-Methoxy-N-methylphenethylamine / Q000009:adverse effects / Q000037:antagonists & inhibitors*
D028321:Plant Preparations; D003189:p-Methoxy-N-methylphenethylamine