title: The impairment of gastroduodenal mucosal barrier by coffee.
abstract: BACKGROUND
  Even though coffee is not considered to be responsible for development of peptic ulcer, it may, however, prolong its healing by increasing acidity of gastric content. In our former work we observed a profound increase in sucrose permeability (above normal values) in healthy volunteers regularly drinking coffee for years. In literature, many factors affecting sucrose permeability have been described so far. None of them, however, studied the effect of coffee.
  
  
  METHODS
  10 young asymptomatic habitual coffee drinkers were included in the study. The probands underwent SaLM test twice--first time without coffee restriction and second time after 48-hour coffee abstinence. The ingested SaLM solution comprised sucrose (25.0 g), lactulose (10.0 g), mannitol (2.0 g), xylose (2.0 g) and water (up to 100 ml). Urine was collected for five hours and the samples were analysed using gas chromatography. Results were compared with those of 8 young healthy volunteers not drinking coffee. Permeability for sucrose was significantly higher in the group of habitual coffee drinkers in comparison with non-coffee drinkers (p < 0.01). After 48-hour coffee abstinence sucrose excretion decreased significantly (p < 0.05) to a level not differing from that of non-coffee drinkers (p = 0.54).
  
  
  CONCLUSIONS
  Our results indicate that coffee may damage gastroduodenal mucosa in habitual coffee drinkers. In a time period of 48 hours the gastroduodenal mucosa is capable of a significant regeneration.
authors.affiliation: Charles University in Prague, Faculty of Medicine, Hradec Králové, Czech Republic. cibickova@seznam.cz
authors.forename: Eubica
authors.initials: E
authors.lastname: Cibicková
authors.forename: Norbert
authors.initials: N
authors.lastname: Cibicek
authors.forename: Petr
authors.initials: P
authors.lastname: Zd'ánský
authors.forename: Pavel
authors.initials: P
authors.lastname: Kohout
mesh_terms: D000328:Adult; D003069:Coffee / Q000009:adverse effects*; D004386:Duodenum / Q000166:cytology / Q000502:physiology*; D005260:Female; D005753:Gastric Mucosa / Q000502:physiology*; D006801:Humans; D007413:Intestinal Mucosa / Q000502:physiology*; D008297:Male; D010539:Permeability; D013395:Sucrose / Q000652:urine
chemical_list: D003069:Coffee; D013395:Sucrose