Post operative analgesia with intrathecal morphine.
BACKGROUND
Sixty eight ASA I and II patients between 18 and 84 years who underwent minor to medium surgery were studied retrospectively. They were divided into 2 groups, on basis on intrathecal morphine administration.


METHODS
Group I received spinal anesthesia with bupivacaine 12.5-15 mg. Group II received in addition 0.1 mg morphine (preservative free) [MO PF]. Pain assessment, up to 24 hours, was evaluated by the need of salvage medication namely pethidine i.m. (intramuscular).


RESULTS
The groups matched for demographic distribution. Twenty one out of 30 patients in Group I needed salvage medication, compared to 6 out of 38 patients in Group II (p < 0.005). Minor complications of intrathecal morphine were noted. These were higher in Group II compared to Group I; itching and pruritus (14 vs. 1); urinary retention (2 vs. 0); nausea and vomiting (1 vs. 0) (p < 0.005).


CONCLUSIONS
This study showed that a single low dose of intrathecal morphine with bupivacaine provides better quality post-operative analgesia than bupivacaine alone, and might offer enough analgesia for minor to medium cases up to 24 hours post-op. However, some side effects have to be taken into consideration.
Sfeir
Samia
S
Anesthesia Department SGH MUC in Association with the University of Balamand.
Mansour
Nabil
N
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D002045:Bupivacaine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage* / Q000009:adverse effects; D010149:Postoperative Pain / Q000188:drug therapy*; D012189:Retrospective Studies
D000701:Analgesics, Opioid; D009020:Morphine; D002045:Bupivacaine