title: [Male breast cancer: about 123 cases collected at the Institute Salah-Azaiz of Tunis from 1979 to 1999].
abstract: Male breast cancer is rare compared to its female counterpart representing less than 1% of cancer in men. The objective of our retrospective study is to report the epidemiologic and clinical profile and to analyse the therapeutic results and prognostic factors in a Tunisian population collected during a period of 20 years at a single institution. We collected from 1979 to 1999, all the histological confirmed male breast cancers treated at our institution. We analyse the following data: age, clinical presentation and features, therapeutic protocol, results and prognostic factors. Survival was done with the Kaplan-Meier method and comparison with the log-rank test. 123 cases of male breast carcinoma were collected with a median age of 65 years. Most patients (62.2%) have an advanced T4 disease with bilateral lesions in 4 cases. Infiltrating ductal carcinoma represent 91% of all tumours. 85% of tumours expressed hormonal receptor. The treatment consisted in a radical mastectomy in 93 cases (84%) followed by radiotherapy, chemotherapy and in many cases by hormonotherapy. After a median follow up of 26 month, 22 patients presented loco regional recurrence and 41 metastases. Estimated 5-year survival rate was 62%. The presence of metastasis, nodal involvement, advanced disease, and grade affected survival. Male breast cancer represent at our institution 1 % of the male cancers treated comparable to the literature data. T4 tumours represent a higher rate, the treatment approach is the standard applicable in breast cancer; prognostic factors are the classical one like breast cancer in women.
authors.affiliation: Service de chirurgie générale carcinologique, Institut Salah-Azaïz, bd du 9 avril, 1006 Bab Saadoun, Tunis, Tunisie. tarek.bendhiab@rns.tn
authors.forename: Tarek
authors.initials: T
authors.lastname: Ben Dhiab
authors.forename: Tarek
authors.initials: T
authors.lastname: Bouzid
authors.forename: Amor
authors.initials: A
authors.lastname: Gamoudi
authors.forename: Jamel
authors.initials: J
authors.lastname: Ben Hassouna
authors.forename: Fethi
authors.initials: F
authors.lastname: Khomsi
authors.forename: Hammouda
authors.initials: H
authors.lastname: Boussen
authors.forename: Farouk
authors.initials: F
authors.lastname: Benna
authors.forename: Ahmed
authors.initials: A
authors.lastname: El May
authors.forename: Monia
authors.initials: M
authors.lastname: Hechiche
authors.forename: Khaled
authors.initials: K
authors.lastname: Rahal
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018567:Breast Neoplasms, Male / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014416:Tunisia / Q000453:epidemiology