Investigation of a nosocomial outbreak of extended-spectrum beta-lactamase VEB-1-producing isolates of Acinetobacter baumannii in a hospital setting.
A nosocomial outbreak of epidemiologically related VEB-1 extended-spectrum beta-lactamase-producing isolates of Acinetobacter baumannii occurred in 33 patients in an intensive care unit. A case-control study identified previous treatment with third-generation cephalosporins as the only risk factor for A. baumannii acquisition. Rationale for antibiotic use should be strengthened.
Carbonne
A
A
Centre inter-régional de lutte contre l'infection nosocomiale (C-CLIN Nord), Institut des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France. acarbonn@bhdc.jussieu.fr
Naas
T
T
Blanckaert
K
K
Couzigou
C
C
Cattoen
C
C
Chagnon
J-L
JL
Nordmann
P
P
Astagneau
P
P
D000151:Acinetobacter Infections / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control; D040981:Acinetobacter baumannii / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification; D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D015373:Bacterial Typing Techniques; D016022:Case-Control Studies; D002511:Cephalosporins / Q000009:adverse effects; D016000:Cluster Analysis; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control; D004269:DNA, Bacterial / Q000032:analysis / Q000235:genetics; D004196:Disease Outbreaks / Q000517:prevention & control / Q000706:statistics & numerical data*; D004363:Drug Utilization; D016521:Electrophoresis, Gel, Pulsed-Field; D029968:Escherichia coli Proteins; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D017053:Infection Control / Q000379:methods; D007362:Intensive Care Units; D016015:Logistic Models; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D015999:Multivariate Analysis; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D012307:Risk Factors; D013997:Time Factors; D018440:beta-Lactam Resistance / Q000235:genetics; D001618:beta-Lactamases / Q000096:biosynthesis
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D004269:DNA, Bacterial; D029968:Escherichia coli Proteins; C119424:beta-lactamase VEB-1, E coli; D001618:beta-Lactamases