title: Panel of prototypical infectious molecular HIV-1 clones containing multiple nucleoside reverse transcriptase inhibitor resistance mutations.
abstract: We have created a panel of recombinant HIV-1 infectious clones containing common patterns of reverse transcriptase (RT) mutations responsible for resistance to each of the currently available nucleoside reverse transcriptase inhibitors (NRTI), and we have submitted the panel to the National Institutes of Health AIDS Research and Reference Reagent Programme. Testing the activity of new antiretroviral compounds against this panel of drug-resistant clones will determine their relative activity against many clinically relevant NRTI-resistant viruses.
authors.affiliation: Division of Infectious Diseases, Stanford University, Stanford, CA, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Johnston
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Dupnik
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Gonzales
authors.forename: Mark A
authors.initials: MA
authors.lastname: Winters
authors.forename: Soo-Yon
authors.initials: SY
authors.lastname: Rhee
authors.forename: Tomozumi
authors.initials: T
authors.lastname: Imamichi
authors.forename: Robert W
authors.initials: RW
authors.lastname: Shafer
mesh_terms: D002999:Clone Cells; D024921:Drug Resistance, Multiple, Viral / Q000235:genetics; D005838:Genotype; D015658:HIV Infections / Q000821:virology*; D054303:HIV Reverse Transcriptase / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics* / Q000302:isolation & purification*; D006801:Humans; D009154:Mutation; D012367:RNA, Viral / Q000302:isolation & purification; D018894:Reverse Transcriptase Inhibitors; D014776:Virus Cultivation
chemical_list: D012367:RNA, Viral; D018894:Reverse Transcriptase Inhibitors; D054303:HIV Reverse Transcriptase