Anti-Müllerian hormone and folliculogenesis.
This paper reviews the role of anti-Müllerian hormone, a member of the TGF(beta) family signaling through a BMP-like pathway, in the ovary. In vivo and in vitro studies showed that AMH has an inhibitory effect on primordial follicle recruitment and it decreases the sensitivity of follicles for the FSH-dependent selection for dominance. Besides its functional role in the ovary, AMH serum level serves as an excellent candidate marker of ovarian reserve.
Visser
Jenny A
JA
Department of Internal Medicine, Section of Endocrinology, Erasmus MC, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands. j.visser@erasmusmc.nl
Themmen
Axel P N
AP
D000818:Animals; D054304:Anti-Mullerian Hormone; D001685:Biological Factors; D005260:Female; D005298:Fertility; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006023:Glycoproteins / Q000502:physiology*; D006801:Humans; D051379:Mice; D006080:Ovarian Follicle / Q000254:growth & development* / Q000378:metabolism; D015398:Signal Transduction; D013735:Testicular Hormones / Q000502:physiology*
D001685:Biological Factors; D006023:Glycoproteins; D013735:Testicular Hormones; D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone