Anaerobic sepsis due to multidrug-resistant Bacteroides fragilis: microbiological cure and clinical response with linezolid therapy.
We describe the first reported case of anaerobic sepsis due to Bacteroides fragilis with simultaneous resistance to metronidazole, beta-lactams, beta lactam/beta-lactamase inhibitors, carbapenems, macrolides, and tetracyclines. Microbiological cure and clinical improvement was achieved with linezolid therapy, an agent that may be useful for the treatment of multidrug-resistant anaerobic infections.
Wareham
D W
DW
Department of Microbiology, Barts & The London NHS Trust, London, United Kingdom. wareham@qmul.ac.uk
Wilks
M
M
Ahmed
D
D
Brazier
J S
JS
Millar
M
M
D000081:Acetamides / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001442:Bacteroides Infections / Q000382:microbiology*; D001441:Bacteroides fragilis / Q000502:physiology*; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D023303:Oxazolidinones / Q000627:therapeutic use*; D018805:Sepsis / Q000188:drug therapy* / Q000382:microbiology*
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid