title: cis-chloropalladation of 1,6-enynes.
abstract: A PdCl(2)-catalyzed cis-chloropalladation-cyclization reaction of various 1,6-enyne substrates was developed. This Pd-catalyzed enyne cyclization reaction represents a new route for the synthesis of stereodefined alpha-halomethylene-gamma-butyrolactones, lactams, tetrahydrofurans, and cyclopentanes. A mechanism involving a neighboring coordination group is proposed to explain the experiment results.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Shanghai 200032, China.
authors.forename: Gangguo
authors.initials: G
authors.lastname: Zhu
authors.forename: Zhaoguo
authors.initials: Z
authors.lastname: Zhang