Effect of glurenorm on immunohistochemical changes in pancreatic beta cells of rats in experimental diabetes.
Immunohistochemical localization of islets of Langerhans of streptozotocin (65 mg/kg, ip) induced diabetic + glurenorm (10 mg/kg, po) treated female albino rats revealed increase in number of beta cells and insulin immunoreactivity of beta cells. The results suggest that glurenorm can cause the stimulation of beta cells of endocrine pancreas in diabetic rats.
Koyuturk
Meral
M
Department of Histology and Embryology, Faculty of Medicine, Kadir Has University, 80810-Gayrettepe, Turkey. mkoyuturk1@yahoo.com
Ozsoy-Sacan
Ozlem
O
Bolkent
Sehnaz
S
Yanardag
Refiye
R
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D005260:Female; D005508:Food Deprivation; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007150:Immunohistochemistry / Q000379:methods*; D007328:Insulin / Q000378:metabolism; D007515:Islets of Langerhans / Q000187:drug effects*; D051381:Rats; D013453:Sulfonylurea Compounds / Q000494:pharmacology*
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D013453:Sulfonylurea Compounds; C010969:gliquidone