title: Rapidly progressive IgA nephropathy.
abstract: A 14-year-old boy presented with macroscopic hematuria and a rapid deterioration in renal function. Percutaneous renal biopsy demonstrated severe crescentic IgA nephropathy (IgAN) with extensive (88%) glomerular crescent formation. After started intravenous administration of high-dose pulse methylprednisolone, severe nausea and general malaise accompanied by a rapid increase in Blood Urea Nitrogen (BUN) and serum creatinine levels appeared, however, the renal function ameliorated rapidly and fully recovered by following oral administration of corticosteroid. The clinical presentation of our case seems to be very remarkable compared to previously reported cases of rapidly progressive IgAN.
authors.affiliation: Department of Pediatric Cardiology, University of Medicine Graduate School of Medical Science, Kyoto, Japan.
authors.forename: Naho
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Masashi
authors.initials: M
authors.lastname: Nishida
authors.forename: Michiko
authors.initials: M
authors.lastname: Aoyama
authors.forename: Kentaro
authors.initials: K
authors.lastname: Yokoi
authors.forename: Tomoyo
authors.initials: T
authors.lastname: Yahata
authors.forename: Tatsujiro
authors.initials: T
authors.lastname: Tatsujiro
authors.forename: Koichi
authors.initials: K
authors.lastname: Sakata
authors.forename: Isao
authors.initials: I
authors.lastname: Shiraishi
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Itoi
authors.forename: Kenji
authors.initials: K
authors.lastname: Hamaoka
mesh_terms: D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D005922:Glomerulonephritis, IGA / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006417:Hematuria / Q000209:etiology; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D016482:Urinalysis
chemical_list: D000893:Anti-Inflammatory Agents; D003404:Creatinine; D008775:Methylprednisolone