title: Gender differences in bone density at different skeletal sites of acquisition with age in Chinese children and adolescents.
abstract: Bone mass acquisition from different genders and races of children and adolescents may vary. To explore gender- and age-related differences in bone mineral density (BMD) measurements in Chinese children and adolescents, we used the dual-energy X-ray absorptiometry (DXA) bone densitometer to take BMD measurements at the posteroanterior (PA) and lateral spine, hip, and forearm in 1286 healthy children and adolescents, ranging from 6 to 24 years of age. Our results show a correlation between BMD measurements taken from different skeletal sites and from different ages of subjects. Male data were best fit to a power regression model, yielding the largest determinant coefficients (R (2)), whereas S regression was the best fitting model for females. In individuals younger than 17 years of age, the rate of BMD accumulation in the PA spine is more rapid in females than in males, whereas in individuals older than 19 years of age, the converse was found to be true. In children younger than 14 years of age, BMD measurements, taken from the lateral spine, the neck and trochanter of the femur, and the total hip, correlated with age similarly in both genders. Additionally, in measurements taken from the forearm ultradistal and 1/3 region, BMD measurements from similar ages of both genders are similar. With increasing age, BMD measurements in males become significantly higher than those of females. However, volumetric BMD (vBMD) measurements from both genders show good uniformity at the lateral spine with a near overlap of the two models. Our findings suggest that vBMD acquisition measurements in Chinese children and adolescents show no gender differences, with gender differences only demonstrated in areal BMD (aBMD) measurements taken from different skeletal sites.
authors.affiliation: Institute of Metabolism and Endocrinology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, 410011 P.R. China.
authors.forename: Xian-Ping
authors.initials: XP
authors.lastname: Wu
authors.forename: Yan-Hong
authors.initials: YH
authors.lastname: Yang
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Ling-Qing
authors.initials: LQ
authors.lastname: Yuan
authors.forename: Xiang-Hang
authors.initials: XH
authors.lastname: Luo
authors.forename: Xin-Zhi
authors.initials: XZ
authors.lastname: Cao
authors.forename: Er-Yuan
authors.initials: EY
authors.lastname: Liao
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015519:Bone Density / Q000502:physiology; D001842:Bone and Bones / Q000000981:diagnostic imaging; D002648:Child; D002681:China; D005260:Female; D006723:Hong Kong; D006801:Humans; D008297:Male; D012044:Regression Analysis; D012727:Sex Characteristics; D013624:Taiwan