title: Nanoscale size effect of magnetic nanocrystals and their utilization for cancer diagnosis via magnetic resonance imaging.
abstract: Since the use of magnetic nanocrystals as probes for biomedical system is attractive, it is important to develop optimal synthetic protocols for high-quality magnetic nanocrystals and to have the systematic understanding of their nanoscale properties. Here we present the development of a synthetically controlled magnetic nanocrystal model system that correlates the nanoscale tunabilities in terms of size, magnetism, and induced nuclear spin relaxation processes. This system further led to the development of high-performance nanocrystal-antibody probe systems for the diagnosis of breast cancer cells via magnetic resonance imaging.
authors.affiliation: Department of Chemistry, Yonsei University, Seoul 120-749, Korea.
authors.forename: Young-Wook
authors.initials: YW
authors.lastname: Jun
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Huh
authors.forename: Jin-Sil
authors.initials: JS
authors.lastname: Choi
authors.forename: Jae-Hyun
authors.initials: JH
authors.lastname: Lee
authors.forename: Ho-Taek
authors.initials: HT
authors.lastname: Song
authors.forename: Sungjun
authors.initials: S
authors.lastname: Kim
authors.forename: Sarah
authors.initials: S
authors.lastname: Yoon
authors.forename: Kyung-Sup
authors.initials: KS
authors.lastname: Kim
authors.forename: Jeon-Soo
authors.initials: JS
authors.lastname: Shin
authors.forename: Jin-Suck
authors.initials: JS
authors.lastname: Suh
authors.forename: Jinwoo
authors.initials: J
authors.lastname: Cheon
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry; D061067:Antibodies, Monoclonal, Humanized; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D001943:Breast Neoplasms / Q000175:diagnosis*; D045744:Cell Line, Tumor; D006801:Humans; D007501:Iron / Q000737:chemistry; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics; D049329:Nanostructures / Q000737:chemistry*; D013440:Sulfides / Q000737:chemistry; D000068878:Trastuzumab
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D001672:Biocompatible Materials; D013440:Sulfides; C111959:greigite; D007501:Iron; D000068878:Trastuzumab