title: Antecedent hypertension interacts with adverse ventricular remodeling after myocardial infarction.
abstract: BACKGROUND
  Ventricular remodeling is an independent predictor of left ventricular function in patients with myocardial infarction (MI). Accelerated ventricular remodeling is a probable contributor to the increased mortality observed after MI in hypertensive patients. The purpose of this study is to assess the relationship of antecedent hypertension to ventricular remodeling after MI.
  
  
  METHODS
  Seventy-nine patients presenting with a first acute MI (AMI) who were treated and attained Thrombolysis In Myocardial Infarction (TIMI) flow grade 3 with re-perfusion therapy within 12 hours of their symptom onset were enrolled in this study. All of them underwent left ventriculography (LVG) immediately after re-perfusion therapy and again at 6 months after the occurrence of MI. Patients were divided into two groups; hypertensive group and normotensive group. End-diastolic volume index (EDVI), end-systolic volume index (ESVI), and EF were compared between acute phase and 6 months after AMI in each group.
  
  
  RESULTS
  The hypertensive group showed a significant increase in both EDVI and ESVI after 6 months, whereas the normotensive group did not. In addition, there was no change in EF in the hypertensive group, whereas EF increased significantly after 6 months in the normotensive group. As a result, percent change in ESVI and EF showed significantly differences between the hypertensive group and normotensive group, whereas percent change in EDVI showed no significant difference between the two groups.
  
  
  CONCLUSIONS
  Antecedent hypertension interacts with ventricular remodeling after MI.
authors.affiliation: Department of Internal Medicine and Cardiology, Osaka City University, Graduate School of Medicine, Japan. m5059985@msic.med.osaka-cu.ac.jp
authors.forename: Kimio
authors.initials: K
authors.lastname: Kamimori
authors.forename: Minoru
authors.initials: M
authors.lastname: Yoshiyama
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Shimada
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Iida
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Eiji
authors.initials: E
authors.lastname: Uchida
authors.forename: Ken
authors.initials: K
authors.lastname: Yoshida
authors.forename: Satoshi
authors.initials: S
authors.lastname: Jissho
authors.forename: Shota
authors.initials: S
authors.lastname: Fukuda
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Takeuchi
authors.forename: Junichi
authors.initials: J
authors.lastname: Yoshikawa
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000503:physiopathology*; D013318:Stroke Volume; D020257:Ventricular Remodeling