title: Impact of the home indoor environment on adult asthma and rhinitis.
abstract: OBJECTIVE
  We sought to study the combined effects of multiple home indoor environmental exposures in adult asthma and rhinitis.
  
  
  METHODS
  We studied 226 adults with asthma and rhinitis by structured interviews and home assessments. Environmental factors included dust allergen, endotoxin and glucan concentrations, and indoor air quality (IAQ) variables. Outcomes included forced expiratory volume in 1 second (FEV1) percent predicted, Severity of Asthma Score (SAS), Short-Form (SF)-12 Physical Component Scale (PCS), and asthma Quality of Life (QOL) score.
  
  
  RESULTS
  House dust-associated exposures together with limited IAQ variables were related to FEV1 % predicted (R = 0.24; P = 0.0001) and SAS (R = 0.18; P = 0.007). IAQ and limited dust variables were associated with SF-12 PCS (R = 0.15; P = 0.02), but not QOL (R = 0.13; P = 0.16).
  
  
  CONCLUSIONS
  The home environment is strongly linked to lung function, health status, and disease severity in adult asthma and rhinitis.
authors.affiliation: Department of Medicine, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94117, USA. blancp@itsa.ucsf.edu
authors.forename: Paul D
authors.initials: PD
authors.lastname: Blanc
authors.forename: Mark D
authors.initials: MD
authors.lastname: Eisner
authors.forename: Patricia P
authors.initials: PP
authors.lastname: Katz
authors.forename: Irene H
authors.initials: IH
authors.lastname: Yen
authors.forename: Connie
authors.initials: C
authors.lastname: Archea
authors.forename: Gillian
authors.initials: G
authors.lastname: Earnest
authors.forename: Susan
authors.initials: S
authors.lastname: Janson
authors.forename: Umesh B
authors.initials: UB
authors.lastname: Masharani
authors.forename: Patricia J
authors.initials: PJ
authors.lastname: Quinlan
authors.forename: S Katharine
authors.initials: SK
authors.lastname: Hammond
authors.forename: Peter S
authors.initials: PS
authors.lastname: Thorne
authors.forename: John R
authors.initials: JR
authors.lastname: Balmes
authors.forename: Laura
authors.initials: L
authors.lastname: Trupin
authors.forename: Edward H
authors.initials: EH
authors.lastname: Yelin
mesh_terms: D016902:Air Pollution, Indoor / Q000009:adverse effects* / Q000032:analysis; D000485:Allergens / Q000302:isolation & purification*; D000818:Animals; D001249:Asthma / Q000145:classification / Q000209:etiology*; D002140:California; D002415:Cats; D004285:Dogs; D004391:Dust; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012220:Rhinitis / Q000209:etiology*; D012720:Severity of Illness Index
chemical_list: D000485:Allergens; D004391:Dust