[Protection of puerarin on the cerebral injury in the rats with acute local ischemia].
OBJECTIVE
To study the protection of puerarin on the cerebral injury in the rats with acute local ischemia.


METHODS
Rat was evaluated model of acute local cerebral ischemia was made by ligating middle cerebral artery. The cerebral damage toxylin and eosin((HE).


RESULTS
The number of died neurons were significantly less in puerarin-treated rats than in the rats with cerebral ischemia (P < 0. 05). Similarly, the cerebral edema were significantly attenuated in the puerarin-treated rats as compared with cerebrally ischemic rats.


CONCLUSIONS
Puerarin can prevent the neuron from damage induced by acute cerebral ischemia.
Pan
Hong-Ping
HP
People's Hospital of Guangxi Autonomous Region, Nanning 530021, China. php1968@126.com
Yang
Jia-Zhen
JZ
Mo
Xiang-Lan
XL
Li
Lu-Li
LL
Huang
Zhen-Lu
ZL
Ye
Jing
J
Huang
Jin
J
D000818:Animals; D002545:Brain Ischemia / Q000473:pathology*; D016923:Cell Death / Q000187:drug effects; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology; D007529:Isoflavones / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014665:Vasodilator Agents / Q000494:pharmacology
D007529:Isoflavones; D018696:Neuroprotective Agents; D014665:Vasodilator Agents; C033607:puerarin