Reduced density of platelet-binding sites for [3H]paroxetine in remitted bulimic women.
Findings show brain serotonin (5-hydroxytryptamine (5-HT)) activity to be altered in individuals who have had bulimia nervosa (BN), even after substantial remission of symptoms. Such findings could reflect persistent sequelae due to BN, or a vulnerability 'trait' that exists independently of active eating-disorder manifestations. We compared women with full-blown BN (BN; n=22), BN in remission (BN-R; n=11), and no eating or psychiatric disturbances (n=22) on measures of platelet [(3)H]paroxetine binding, eating symptoms and psychopathology. The BN-R group showed normal-range scores on eating and psychopathological symptoms, but reductions in density (B(max)) of binding sites for paroxetine similar to those obtained in the actively ill women. Both BN groups had substantially lower B(max) than did healthy controls. Our results corroborate other findings indicating recovered BN patients to have anomalous 5-HT functioning. While such effects could represent a lasting 'injury' to the system, reported covariations between personality traits and 5-HT indices in BN encourage us to favor the argument that some alterations of 5-HT activity (in this case, consistent with reduced transporter activity) represent a 'trait' associated with the risk of developing BN and/or associated psychopathology.
Steiger
Howard
H
Eating Disorders Program, Douglas Hospital, Montreal, Quebec, Canada. stehow@douglas.mcgill.ca
Richardson
Jodie
J
Israel
Mimi
M
Ng Ying Kin
N M K
NM
Bruce
Kenneth
K
Mansour
Sandra
S
Marie Parent
Anne
A
D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000097:blood* / Q000627:therapeutic use; D001665:Binding Sites; D001792:Blood Platelets / Q000378:metabolism*; D002032:Bulimia / Q000097:blood* / Q000188:drug therapy / Q000523:psychology; D002400:Cathartics; D004232:Diuretics; D005260:Female; D006801:Humans; D017374:Paroxetine / Q000097:blood* / Q000627:therapeutic use; D011569:Psychiatric Status Rating Scales; D019966:Substance-Related Disorders / Q000097:blood / Q000523:psychology; D014839:Vomiting / Q000097:blood / Q000523:psychology
D018687:Antidepressive Agents, Second-Generation; D002400:Cathartics; D004232:Diuretics; D017374:Paroxetine