Retymicin, galtamycin B, saquayamycin Z and ribofuranosyllumichrome, novel secondary metabolites from Micromonospora sp. Tü 6368. II. Structure elucidation.
A detailed screening of the secondary metabolite pattern from Micromonospora sp. strain Tü 6368 resulted in the isolation of ten compounds belonging to five different structural families. The structures of the novel compounds 1-(alpha-ribofuranosyl)-lumichrome (3), retymicin (7), galtamycin B (11) and saquayamycin Z (14) were assigned by spectroscopic methods and chemical transformations. This strain fits our hypothesis that the metabolite analysis of biosynthetically talented strains leads readily to novel compounds.
Ströch
Karsten
K
Institut für Organische und Biomolekulare Chemie, Universität Gottingen, Tammannstr. 2, D-37077 Göttingen, Germany.
Zeeck
Axel
A
Antal
Noémi
N
Fiedler
Hans-Peter
HP
D018943:Anthracyclines / Q000737:chemistry*; D000880:Anthraquinones / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D002240:Carbohydrate Sequence; D005415:Flavins / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008847:Micromonospora / Q000737:chemistry*; D008969:Molecular Sequence Data; D009005:Monosaccharides / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D044004:Xanthones / Q000737:chemistry*; D000095602:Angucyclines and Angucyclinones
D018943:Anthracyclines; D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D005415:Flavins; D009005:Monosaccharides; D044004:Xanthones; C500114:retymicin; C500115:ribofuranosyllumichrome; C049641:galtamycin; C046893:saquayamycin; D000095602:Angucyclines and Angucyclinones