[Clinical characteristic and treatment of laryngeal scleroma].
OBJECTIVE
To study the clinical manifestation and treatment of the laryngeal scleroma


METHODS
Forty-three patients with laryngeal scleroma, from May, 1981 to December, 2002, with pathological diagnosed were reviewed retrospectively. The clinical features and the treatment methods of these patients were analysed.


RESULTS
All 43 cases had hoarseness and 19 of them manifested dyspnea. In the larynx, the main scleromatous lesions were classified as atrophic stage in 2 cases, as granulomatous in 35 cases and as scarring in 6 cases. The preponderance lesions were located in the glottis in 13 cases, in the subglottis in 1 case, in both supraglottis and glottis in 18 cases, in both glottis and subglottis in 8 cases, and in all the three regions of the larynx in 3 cases. Twenty-four patients were treated with antibiotics, seven patients with surgery and two patients with radiotherapy. Eighteen of 24 patients who were treated with antibiotics were cured, and two of the recurrent patients were cured with a further period of antibiotics therapy. Four of the 24 patients with second or third degree of laryngeal obstruction required prophylactic tracheostomy. One patient in granulomatous stage with the second degree of laryngeal obstruction was cured with the combination of surgery and antibiotics therapy. Six patients in the scarring stage with laryngeal stenosis were cured with reconstruction surgery. One patient treated with radiotherapy recurred in the fourth year after treatment, and one patient failed to antibiotics therapy cured with radiotherapy combined with antibiotics therapy.


CONCLUSIONS
Scleroma may involve the larynx and cause dysphonia and laryngeal obstruction. Antibiotics therapy is effective in most cases with laryngeal scleroma, and the long-time follow-up after treatment were necessary. Laryngeal reconstructions were necessary for the patients with cicatrical laryngeal stenosis.
Sun
Yan
Y
Department of Otorhinolaryngology, Affiliated Hospital of Medical College of Qingdao University, Qingdao 266003, China. sunnyohns@hotmail.com
Liu
Yun-chao
YC
Chen
Zhi-jun
ZJ
D000293:Adolescent; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007818:Laryngeal Diseases / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012226:Rhinoscleroma / Q000628:therapy