Ocular complications of sigmoid sinus thrombosis from L-asparaginase.
This article presents a 9-year-old boy with acute lymphocytic leukemia who developed ocular complications after beginning treatment with L-asparaginase. Ocular motor examination revealed esotropia with a right abduction deficit, consistent with a sixth nerve palsy, and funduscopy revealed bilateral optic disc edema. Thrombosis of the right sigmoid sinus was noted on magnetic resonance imaging and magnetic resonance venography. Symptoms gradually resolved after discontinuing L-asparaginase and treatment with heparin.
Foroozan
Rod
R
Neuro-Ophthalmology Service, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas 77030, USA.
D000010:Abducens Nerve; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001215:Asparaginase / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D003389:Cranial Nerve Diseases / Q000209:etiology; D004948:Esotropia / Q000209:etiology; D005128:Eye Diseases / Q000209:etiology*; D005654:Fundus Oculi; D006801:Humans; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008297:Male; D010211:Papilledema / Q000175:diagnosis / Q000209:etiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D012851:Sinus Thrombosis, Intracranial / Q000139:chemically induced* / Q000150:complications* / Q000175:diagnosis
D000970:Antineoplastic Agents; D001215:Asparaginase