title: Related enzymes solve evolutionarily recurrent problems in the metabolism of carotenoids.
abstract: Chemical transformations of isoprenoids in plants and some bacteria and fungi lead to the production of various conjugated products, including carotenoids. Carotenoids can be cleaved to generate apocarotenoid precursors for signaling molecules such as abscisic and retinoic acids, and for the photosensory pigment retinal. The enzymes that catalyze the various transformations of carotenoids and apocarotenoids are closely related. This evolutionarily distant conservation is unexpected and intriguing. Many aspects of the metabolism of retinoids in vertebrates remain controversial and poorly understood. Because few chemical reactions are possible for this group of compounds, furthering our knowledge of isoprenoid transformation in plants could be beneficial to our understanding of how retinoids and carotenoids are transformed in vertebrates.
authors.affiliation: Department of Ophthalmology, University of Washington, Seattle, WA 98195, USA. moise@u.washington.edu
authors.forename: Alexander R
authors.initials: AR
authors.lastname: Moise
authors.forename: Johannes
authors.initials: J
authors.lastname: von Lintig
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Palczewski
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D002338:Carotenoids / Q000737:chemistry / Q000378:metabolism*; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010105:Oxygenases / Q000737:chemistry / Q000378:metabolism; D010860:Pigments, Biological / Q000502:physiology; D010944:Plants / Q000201:enzymology*; D017386:Sequence Homology, Amino Acid
chemical_list: D010860:Pigments, Biological; D002338:Carotenoids; D010105:Oxygenases