title: Menopausal vasomotor symptoms: a review of causes, effects and evidence-based treatment options.
abstract: Vasomotor symptoms are the most common medical complaint of perimenopausal and postmenopausal women. Frequent vasomotor symptoms can be disabling, affecting a woman's social life, psychological health, sense of well-being and ability to work. Women with hot flushes are more likely to experience disturbed sleep, depressive symptoms and significant reductions in quality of life as compared to asymptomatic women. Despite the prevalence and impact of these symptoms, the pathophysiology of hot flushes is unclear; however, estrogen withdrawal clearly plays an important role. It is postulated that declining estrogen concentrations may lead to changes in brain neurotransmitters and instability in the hypothalamic thermoregulatory center. The most effective therapy for relieving vasomotor symptoms and reducing their impact on quality of life is hormone therapy. Other options for women who decline hormone therapy include selective serotonin reuptake inhibitors and related agents. Most herbal therapies that have been evaluated in placebo-controlled trials have shown no clinically significant benefit.
authors.affiliation: Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08901, USA. bachmaga@umdnj.edu
authors.forename: Gloria A
authors.initials: GA
authors.lastname: Bachmann
mesh_terms: D000368:Aged; D001833:Body Temperature Regulation; D004958:Estradiol / Q000097:blood; D019317:Evidence-Based Medicine; D005260:Female; D029001:Herbal Medicine; D020249:Hormone Replacement Therapy; D019584:Hot Flashes / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D008593:Menopause; D008875:Middle Aged; D011788:Quality of Life; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use
chemical_list: D004958:Estradiol; D017367:Selective Serotonin Reuptake Inhibitors