[Estimation of the influence of physical and biological factors on the development of the hematopoietic type of radiation sickness in dogs and two types of monkeys].
In this investigation, the analysis of radiobiological experiments on 532 dogs and two types of monkeys (101 animals), irradiated totally in the 1.0 to 6.0 Gy dose range at different irradiation facilities, has been carried out. LD50 values at X-ray and gamma-neutron exposure were close to each other (2.35 and 2.83 Gy, respectively) while at gamma-radiation exposure LD(50/45) increased to 3.09 Gy. Comparison of LD(50/45) values for different kinds of animals allowed us to draw a conclusion of approximately equal radiosensitivities of dogs and Macaca fascicularis monkeys (LD(50/30-45) - 3.09 Gy and 3.17 Gy, respectively); Macaca rhesus monkeys revealed higher radioresistance (LD(50/30-45) - 5.03Gy). Analysis of the influence of several biological factors has not displayed any significant differences in the values of LD(50/45) and average lifespan of male and female dogs. Higher radiosensitivity of dogs with body weight less than 12 kg and lower radiosensitivity of dogs in summer time compared to other seasons have been shown. Dogs at the age of 2 to 3 years appeared to be more radioresistant than animals of the other age.
Darenskaia
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TA
Nasonova
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TA
D000367:Age Factors; D000818:Animals; D004285:Dogs; D005720:Gamma Rays; D007928:Lethal Dose 50; D007953:Leukemia, Radiation-Induced / Q000209:etiology* / Q000503:physiopathology; D007958:Leukocyte Count; D007970:Leukopenia / Q000209:etiology / Q000503:physiopathology; D019891:Leukopoiesis / Q000528:radiation effects*; D008252:Macaca fascicularis; D008253:Macaca mulatta; D011833:Radiation Injuries, Experimental / Q000209:etiology*; D011836:Radiation Tolerance; D012621:Seasons; D012737:Sex Factors; D014916:Whole-Body Irradiation