Cerebellar liponeurocytoma: morphological, immunohistochemical, and ultrastructural study of a relapsed case.
Cerebellar liponeurocytoma is a rare and newly identified neoplasm found in adults which is reputed to be benign. Its salient morphological characteristics are advanced neuronal/neurocytic differentiation, the presence of lipomatous areas, low mitotic rate, and the absence of necrosis, pleomorphism and vascular hyperplasia. Reported is a case of relapsing liponeurocytoma which occurred 3 and a half years after the radical excision of the primary lesion. Histopathological aggressive features (mitoses and a high proliferation index as evaluated by MIB-1) were shown in the primary lesion and recurrence of the tumor. We suggest that liponeurocytoma is an uncertain malignant potential lesion when mitoses are present and the MIB-1 positive cells are more than 10%.
Buccoliero
Anna Maria
AM
Departments of Human Pathology and Oncology, University of Florence, Florence, Italy. ambuccoliero@unifi.it
Caldarella
Adele
A
Bacci
Stefano
S
Gallina
Pasquale
P
Taddei
Antonio
A
Di Lorenzo
Nicola
N
Romagnoli
Paolo
P
Taddei
Gian Luigi
GL
D002528:Cerebellar Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008527:Medulloblastoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000473:pathology* / Q000601:surgery
D019394:Ki-67 Antigen