Effects of hypoglycemia on developmental outcome in children with congenital hyperinsulinism.
Children with congenital hyperinsulinism are at risk for recurring, severe episodes of hypoglycemia that can cause seizures, brain damage, and developmental delay. To assess the frequency of permanent brain damage in this disorder, we carried out a telephone survey of 68 children who presented to The Children's Hospital of Philadelphia between 1980 and 2000. One third of the group had some degree of developmental delay. Those presenting in the first week of life and those with medically unresponsive hyperinsulinism were more likely to have delays. Early recognition and control of hypoglycemia are essential for preventing developmental delay in these children.
Steinkrauss
Linda
L
Department of Endocrinology, The Children's Hospital of Philadephia, PA 19104, USA. ljsteinkrauss@hotmail.com
Lipman
Terri H
TH
Hendell
Christine D
CD
Gerdes
Marsha
M
Thornton
Paul S
PS
Stanley
Charles A
CA
D017677:Age Distribution; D020208:Brain Injury, Chronic / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D044903:Congenital Hyperinsulinism / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D002658:Developmental Disabilities / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D006306:Health Surveys; D006776:Hospitals, Pediatric; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007361:Intelligence Tests; D008297:Male; D024802:Nurse's Role; D010371:Pediatric Nursing; D015143:Philadelphia / Q000453:epidemiology; D012307:Risk Factors; D012640:Seizures / Q000209:etiology; D011795:Surveys and Questionnaires