title: Dysfunction of simian immunodeficiency virus/simian human immunodeficiency virus-induced IL-2 expression by central memory CD4+ T lymphocytes.
abstract: Production of IL-2 and IFN-gamma by CD4+ T lymphocytes is important for the maintenance of a functional immune system in infected individuals. In the present study, we assessed the cytokine production profiles of functionally distinct subsets of CD4+ T lymphocytes in rhesus monkeys infected with pathogenic or attenuated SIV/simian human immunodeficiency virus (SHIV) isolates, and these responses were compared with those in vaccinated monkeys that were protected from immunodeficiency following pathogenic SHIV challenge. We observed that preserved central memory CD4+ T lymphocyte production of SIV/SHIV-induced IL-2 was associated with disease protection following primate lentivirus infection. Persisting clinical protection in vaccinated and challenged monkeys is thus correlated with a preserved capacity of the peripheral blood central memory CD4+ T cells to express this important immunomodulatory cytokine.
authors.affiliation: Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Yue
authors.initials: Y
authors.lastname: Sun
authors.forename: Jörn E
authors.initials: JE
authors.lastname: Schmitz
authors.forename: Paula M
authors.initials: PM
authors.lastname: Acierno
authors.forename: Sampa
authors.initials: S
authors.lastname: Santra
authors.forename: Ramu A
authors.initials: RA
authors.lastname: Subbramanian
authors.forename: Dan H
authors.initials: DH
authors.lastname: Barouch
authors.forename: Darci A
authors.initials: DA
authors.lastname: Gorgone
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Lifton
authors.forename: Kristin R
authors.initials: KR
authors.lastname: Beaudry
authors.forename: Kelledy
authors.initials: K
authors.lastname: Manson
authors.forename: Valerie
authors.initials: V
authors.lastname: Philippon
authors.forename: Ling
authors.initials: L
authors.lastname: Xu
authors.forename: Holden T
authors.initials: HT
authors.lastname: Maecker
authors.forename: John R
authors.initials: JR
authors.lastname: Mascola
authors.forename: Dennis
authors.initials: D
authors.lastname: Panicali
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Nabel
authors.forename: Norman L
authors.initials: NL
authors.lastname: Letvin
mesh_terms: D016915:AIDS Vaccines / Q000494:pharmacology; D000818:Animals; D018106:CD28 Antigens / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D015683:Gene Products, gag; D006678:HIV / Q000276:immunology* / Q000472:pathogenicity; D015658:HIV Infections / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D006801:Humans; D007156:Immunologic Memory; D066298:In Vitro Techniques; D007371:Interferon-gamma / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis*; D008253:Macaca mulatta; D012367:RNA, Viral / Q000097:blood; D018449:SAIDS Vaccines / Q000494:pharmacology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000276:immunology* / Q000472:pathogenicity; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D019014:fas Receptor / Q000378:metabolism
chemical_list: D016915:AIDS Vaccines; D018106:CD28 Antigens; D015683:Gene Products, gag; D007376:Interleukin-2; D012367:RNA, Viral; D018449:SAIDS Vaccines; D014409:Tumor Necrosis Factor-alpha; D019014:fas Receptor; D007371:Interferon-gamma