Serum xylosyltransferase I activity, the new biochemical fibrosis marker, is not affected by renal insufficiency.
OBJECTIVE
Serum xylosyltransferase I (XT-I) is a marker for the determination of tissue remodeling in systemic sclerosis. Here, we investigated whether renal insufficiency affects XT-I levels in blood.


METHODS
We measured serum XT-I activity in 236 patients with different serum creatinine levels.


RESULTS
XT-I activities in cohorts with increased creatinine levels were not significantly altered compared to controls.


CONCLUSIONS
Serum XT-I activity is applicable as a fibrosis marker independent from renal function.
Schöttler
Manuela
M
Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Georgstrasse 11, 32545 Bad Oeynhausen, Germany.
Müller
Sandra
S
Schön
Sylvia
S
Prante
Christian
C
Kuhn
Joachim
J
Kleesiek
Knut
K
Götting
Christian
C
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000150:complications; D008297:Male; D008875:Middle Aged; D010430:Pentosyltransferases / Q000097:blood*; D051437:Renal Insufficiency / Q000097:blood* / Q000150:complications; D000097608:UDP Xylose-Protein Xylosyltransferase
D015415:Biomarkers; D003404:Creatinine; D010430:Pentosyltransferases; D000097608:UDP Xylose-Protein Xylosyltransferase