[Immunohistochemical investigation of steroid hormones (ER, PR) in breast cancer].
Immunohistochemical investigations were performed in 22 cases of breast cancer. The objective of this study was to assess the presence and distribution of ER and PR in the cancer tissue. We found that expression of the ER and PR in the cancer tissue is variable, which depends on cancer histogenesis (lobular, ductal), histological form, differentiation grade, and stage of its development. Level of the expression of ER and PR was higher in the ductal form than in the lobular form of breast cancer. Expression of the ER was significantly higher than expression of PR in the case of the lobular form. There were no similar differences seen in cases of ductal form of breast cancer.
Mchedlishvili
M Iu
MIu
Gabunia
U A
UA
Makharoblidze
E R
ER
Burnadze
K T
KT
Piradashvili
D Z
DZ
D000328:Adult; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000473:pathology; D018275:Carcinoma, Lobular / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009367:Neoplasm Staging; D011960:Receptors, Estrogen / Q000032:analysis* / Q000378:metabolism; D011980:Receptors, Progesterone / Q000032:analysis* / Q000378:metabolism
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone