title: Primary squamous cell carcinoma of the liver arising from a complex liver cyst: report of a case.
abstract: A 65-year-old man who had received radiation therapy for nasopharyngeal cancer (NPC) 3 years earlier presented with a 3-week history of right upper quadrant abdominal pain and a feeling of fullness. There had been no evidence of metastasis on his follow-up examinations. Computed tomography scan showed a huge complex cyst with septa in the right hepatic lobe, and we performed an extended right hepatectomy to relieve his symptoms. Pathological examination revealed a large hepatic cyst with malignant cells along the cyst wall. The cytokeratin stain and CK-14 stains were positive, indicating an undifferentiated squamous cell carcinoma (SCC). The final diagnosis of primary SCC of the liver was confirmed by the clinical pathological features and negative in situ hybridization of Epstein-Barr ribonucleic acids (EBERs). We used EBERs to determine whether the cystic tumor was a primary lesion or a metastatic lesion from the previous NPC.
authors.affiliation: Department of Surgery, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan.
authors.forename: Chung-Bao
authors.initials: CB
authors.lastname: Hsieh
authors.forename: Cheng-Jueng
authors.initials: CJ
authors.lastname: Chen
authors.forename: Jyh-Cherng
authors.initials: JC
authors.lastname: Yu
authors.forename: Tzu-Ming
authors.initials: TM
authors.lastname: Chang
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Gao
authors.forename: Yao-Chi
authors.initials: YC
authors.lastname: Liu
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D003560:Cysts / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D006498:Hepatectomy; D006801:Humans; D008107:Liver Diseases / Q000473:pathology* / Q000601:surgery; D008113:Liver Neoplasms / Q000473:pathology* / Q000601:surgery; D008297:Male