title: Coronary atherosclerosis in patients with acquired valvular disease.
abstract: BACKGROUND
  Coronary atherosclerosis often coexists with acquired valvular disorders. There is growing evidence in literature that these two conditions may have common aetiology.
  
  
  OBJECTIVE
  To assess the incidence of coronary atherosclerosis in patients with acquired valvular disorders and to compare clinical parameters as well as the prevalence of risk factors between patients with aortic and mitral valve diseases.
  
  
  METHODS
  The study group consisted of 155 patients (101 males, 54 females, mean age 58.2+/-9.7 years) with acquired valvular disorder who between 2000 and 2002 underwent invasive cardiac evaluation in our department prior to planned cardiac surgery. Aortic stenosis was detected in 74 patients, aortic insufficiency -- in 26, mitral stenosis -- in 33, and mitral regurgitation -- in 14 subjects. All patients underwent clinical evaluation, echocardiography, coronary angiography and laboratory tests.
  
  
  RESULTS
  Patients with aortic stenosis had similar prevalence of coronary atherosclerosis to patients with aortic insufficiency, and patients with mitral stenosis -- to patients with mitral regurgitation. When the two groups -- patients with aortic valve disease and patients with mitral valve disease were compared, significant coronary lesions were more often detected in patients with aortic valve disease (36% vs 12.8%, p<0.05). Also, patients with aortic valve disorder were older, predominantly of male gender, had more often angina but less often heart failure, and had higher total cholesterol level than patients with mitral valve disease.
  
  
  CONCLUSIONS
  Significant coronary lesions are more frequently encountered in patients with aortic valve disorder than in those with mitral valve disease. A high prevalence of atherosclerotic risk factors in patients with aortic valve disease may suggest that this condition has similar aetiology to that of coronary artery disease.
authors.affiliation: Department of Cardiology, Medical Academy, Lublin, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Zapolski
authors.forename: Andrzej
authors.initials: A
authors.lastname: Wysokiński
authors.forename: Jerzy
authors.initials: J
authors.lastname: Przegaliński
authors.forename: Jarosław
authors.initials: J
authors.lastname: Wójcik
authors.forename: Andrzej
authors.initials: A
authors.lastname: Tomaszewski
authors.forename: Jakub
authors.initials: J
authors.lastname: Drozd
authors.forename: Andrzej
authors.initials: A
authors.lastname: Madejczyk
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Pijanowski
authors.forename: Teresa
authors.initials: T
authors.lastname: Widomska-Czekajska
mesh_terms: D000368:Aged; D001022:Aortic Valve Insufficiency / Q000150:complications*; D001024:Aortic Valve Stenosis / Q000150:complications*; D003324:Coronary Artery Disease / Q000150:complications* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000150:complications*; D008946:Mitral Valve Stenosis / Q000150:complications*; D011044:Poland / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors