title: Intravenous amitraz poisoning.
abstract: Amitraz, a derivative of dimethylformamidine, is an acariside and insecticide used to control parasites in animals. Amitraz inhibits monoamine oxidase and prostaglandin synthesis and is an alpha-2 adrenergic agonist. Xylene, a mixture of o-, m-, and p-dimethylbenzene, is widely used in industry. A 22-year-old woman was poisoned by an intravenous injection of 5-6 mL of an amitraz formulation (amitraz 12.5% + xylene 57.5%). Clinical findings were coma (Glasgow coma score 3), respiratory depression, hypotension, bradycardia, hematuria, and edema and hyperemia at the injection site. Although her coma and other symptoms quickly resolved, as has been seen in oral and dermal amitraz poisoning, intoxication with higher doses occurring from intravenous injection may result in more serious problems.
authors.affiliation: Department of Anesthesiology, Cumhuriyet University School of Medicine, Sivas, Turkey. sgursoy@cumhuriyet.edu.tr
authors.forename: Sinan
authors.initials: S
authors.lastname: Gursoy
authors.forename: Nur
authors.initials: N
authors.lastname: Kunt
authors.forename: Kenan
authors.initials: K
authors.lastname: Kaygusuz
authors.forename: Haluk
authors.initials: H
authors.lastname: Kafali
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000506:poisoning*; D000328:Adult; D001919:Bradycardia / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced / Q000188:drug therapy; D007275:Injections, Intravenous; D007306:Insecticides / Q000506:poisoning*; D020258:Neurotoxicity Syndromes / Q000209:etiology / Q000628:therapy; D011041:Poisoning / Q000097:blood / Q000188:drug therapy; D013406:Suicide, Attempted; D013997:Time Factors; D014052:Toluidines / Q000008:administration & dosage / Q000506:poisoning*; D014992:Xylenes / Q000008:administration & dosage / Q000506:poisoning*
chemical_list: D000316:Adrenergic alpha-Agonists; D007306:Insecticides; D014052:Toluidines; D014992:Xylenes; C014983:amitraz