title: [Morbidity at 2 years in infants with a birth weight of < 1,500 g].
abstract: OBJECTIVE
  To determine morbidity at 2 years' corrected age in a cohort of neonates with a birth weight of less than 1,500 g born in 1999-2000 in a tertiary hospital in the Autonomous Community of Madrid.
  
  
  METHODS
  An observational longitudinal follow-up study was performed in a cohort of 213 infants with a birth weight of < 1,500 g. Of these, 188 (87%) completed the 2-year follow-up. Various types of neurosensorial disability were studied, paying special attention to the main impairments: vision, hearing and motor impairment, and low development quotient.
  
  
  RESULTS
  Among the patients initially included in the study, 87% completed the follow-up; 17.1% had one or more major sequela. We found one case (0.4%) of bilateral neurosensorial deafness and one case of bilateral blindness. At the age of 2 years, 5.8 % (11/188) had cerebral palsy, 14.9% had a development quotient below 85 and 18% had not reached the 3rd percentile for weight. Factors of poor neurological prognosis were subnormal head size at the age of 2 years and white matter disease (including persistent intraparenchymal periventricular echodensity and ventriculomegaly or irregular shape) as ultrasound findings.
  
  
  CONCLUSIONS
  Less than a fifth of the very low birth weight infants presented severe sequelae at 2 years of follow-up. Factors of poor neurological prognosis were subnormal head size at 2 years and the presence of white matter disease on ultrasonography. The findings on growth and development were worrying, since 18 % of the patients had not reached the 3rd percentile for weight at 2 years' corrected age.
authors.affiliation: Servicio de Neonatología, Hospital Infantil La Paz, 28047 Madrid, España. drnatalio@yahoo.es
authors.forename: N
authors.initials: N
authors.lastname: Hernández González
authors.forename: S
authors.initials: S
authors.lastname: Salas Hernández
authors.forename: A
authors.initials: A
authors.lastname: García-Alix Pérez
authors.forename: C
authors.initials: C
authors.lastname: Roche Herrero
authors.forename: J
authors.initials: J
authors.lastname: Pérez Rodríguez
authors.forename: F
authors.initials: F
authors.lastname: Omeñaca Teres
authors.forename: J
authors.initials: J
authors.lastname: Quero Jiménez
mesh_terms: D015331:Cohort Studies; D002658:Developmental Disabilities; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight / Q000254:growth & development; D009017:Morbidity