title: Degradation of beta-Hexachlorocyclohexane by Haloalkane Dehalogenase LinB from Sphingomonas paucimobilis UT26.
abstract: Beta-Hexachlorocyclohexane (beta-HCH) is the most recalcitrant among the alpha-, beta-, gamma-, and delta-isomers of HCH and causes serious environmental pollution problems. We demonstrate here that the haloalkane dehalogenase LinB, reported earlier to mediate the second step in the degradation of gamma-HCH in Sphingomonas paucimobilis UT26, metabolizes beta-HCH to produce 2,3,4,5,6-pentachlorocyclohexanol.
authors.affiliation: Department of Environmental Life Sciences, Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Sendai 980-8577, Japan. aynaga@ige.tohoku.ac.jp
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nagata
authors.forename: Zbynek
authors.initials: Z
authors.lastname: Prokop
authors.forename: Yukari
authors.initials: Y
authors.lastname: Sato
authors.forename: Petr
authors.initials: P
authors.lastname: Jerabek
authors.forename: Ashwani
authors.initials: A
authors.lastname: Kumar
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ohtsubo
authors.forename: Masataka
authors.initials: M
authors.lastname: Tsuda
authors.forename: Jirí
authors.initials: J
authors.lastname: Damborsky
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001673:Biodegradation, Environmental; D003511:Cyclohexanols / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D001556:Hexachlorocyclohexane / Q000378:metabolism*; D006867:Hydrolases / Q000235:genetics / Q000378:metabolism*; D020578:Sphingomonas / Q000201:enzymology* / Q000235:genetics
chemical_list: C525117:2,3,4,5,6-pentachlorocyclohexanol; D001426:Bacterial Proteins; D003511:Cyclohexanols; D001556:Hexachlorocyclohexane; D006867:Hydrolases; C046137:haloalkane dehalogenase; C023888:beta-hexachlorocyclohexane