New cytotoxic sulfated saponins from the starfish Certonardoa semiregularis.
Two new sulfated saponins designated as certonardosides P2 and I3 (1 and 2) were isolated from the brine shrimp active fraction of the MeOH extract of the starfish Certonardoa semiregularis. The structures were determined on the basis of spectral analysis. Compounds 1 and 2 were tested for cytotoxicity against five human tumor cell lines (A549, SK-OV-3, SK-MEL-2, XF498, and HCT15), and compound 1 displayed significant cytotoxicity against the SK-MEL-2 skin cancer cell.
Wang
Weihong
W
College of Pharmacy, Pusan National University, Busan 609-735, Korea.
Jang
Hyojin
H
Hong
Jongki
J
Lee
Chong-Ok
CO
Bae
Song-Ja
SJ
Shin
Sook
S
Jung
Jee H
JH
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013215:Starfish / Q000737:chemistry*; D013451:Sulfonic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D012503:Saponins; D013451:Sulfonic Acids; C502703:certonardoside P13; C502702:certonardoside P2