Acute myopathy in a patient with lung adenocarcinoma treated with gemcitabine and docetaxel.
An extremely rare case of acute inflammatory myopathy during combination chemotherapy with gemcitabine and docetaxel for advanced non-small cell lung cancer in a 57-year-old diabetic male patient is reported. Despite the early clinical partial response of the underlying malignancy to the chemotherapeutic regimen, the patient developed symmetrical, painful, proximal muscle weakness in the lower limbs with peripheral edema after the administration of the fourth cycle of treatment. The syndrome regressed definitely after the discontinuation of chemotherapy and the administration of corticosteroids. The diagnosis of drug-induced myositis is supported after the exclusion of other possible diagnoses.
Ardavanis
Alexandros S
AS
First Department of Medical Oncology, St Savas Anticancer- Oncologic Hospital, Athens, Greece. ardavanis@yahoo.com
Ioannidis
Georgios N
GN
Rigatos
Gerassimos A
GA
D000230:Adenocarcinoma / Q000150:complications* / Q000188:drug therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications* / Q000188:drug therapy*; D003841:Deoxycytidine / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D000077143:Docetaxel; D004487:Edema / Q000139:chemically induced; D006801:Humans; D007249:Inflammation; D008175:Lung Neoplasms / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000175:diagnosis* / Q000209:etiology*; D043823:Taxoids / Q000008:administration & dosage*; D000093542:Gemcitabine
D043823:Taxoids; D003841:Deoxycytidine; D000077143:Docetaxel; D000093542:Gemcitabine