title: Chronic kidney disease in the elderly; a silent epidemic.
abstract: Chronic kidney disease has been shown to be associated with significant increases in mortality and morbidity even in early stages. Despite this it is rarely diagnosed, actively investigated or managed in the elderly. We set out to establish the prevalence of CKD and identify causative factors in a consecutive series of referrals to a geriatric medical clinic. We calculated glomerular filtration rates (GFR) for 101 patients attending a geriatric medical clinic using the Cockroft and Gault formula, and collected data on medications and relevant past medical history. Mild CKD (GFR <60ml/min) was present in 80% of the group. Only 10% of these patients had serum creatinine >130(mmol/L. hypertension was present in 50% and only 9% were diabetic. Almost one third were on inappropriate drugs or dosages; most commonly non-steroidal anti-inflammatory drugs (99%). Chronic kidney disease is extremely common in older people attending a geriatric medical clinic and carries significant risks. CKD will not be detected by serum creatinine alone in 90% of cases. Routine calculation of GFR should be used to provide a more accurate measure of renal impairment and allow earlier intervention, risk factor reduction and improve prescribing practices.
authors.affiliation: Depts of Medical Gerontology and Nephrology, Trinity Centre for Health Sciences, Adelaide & Meath Hospital, Dublin 24. arhc@amnch.ie
authors.forename: A
authors.initials: A
authors.lastname: Martin
authors.forename: G
authors.initials: G
authors.lastname: Mellotte
authors.forename: D
authors.initials: D
authors.lastname: O'Neill
mesh_terms: D000368:Aged; D002908:Chronic Disease; D003404:Creatinine / Q000097:blood; D004196:Disease Outbreaks; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007494:Ireland / Q000453:epidemiology; D007674:Kidney Diseases / Q000188:drug therapy / Q000453:epidemiology*; D008297:Male; D010044:Outpatient Clinics, Hospital; D011446:Prospective Studies
chemical_list: D003404:Creatinine