title: [Purification of a small peptide SV-PP-3 from the venom of Agkistrodon blomhoffii siniticus and its inhibition of platelet aggregation].
abstract: OBJECTIVE
  To investigate the inhibitory effect of the small peptide SV-PP-3 from the venom of Agkistrodon blomhoffii siniticus on platelet aggregation.
  
  
  METHODS
  The small peptide SV-PP-3 was isolated and purified by centrifugation at low temperature, sephadex G-75 column chromatography and reverse-phase (HPLC) on C-18 column. The platelet aggregation induced by adenosine diphosphate (ADP) was measured by LBY-NJ aggregometer.
  
  
  RESULTS
  SV-PP-3 was purified from the venom of Agkistrodon blomhoffii siniticus, which inhibited the platelet ADP-induced platelet aggregation in a dose-dependent manner.
  
  
  CONCLUSIONS
  SV-PP-3 can inhibit ADP-Induced platelet aggregation.
authors.affiliation: Institute of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. xuwei@fimmu.com
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Shao-Yu
authors.initials: SY
authors.lastname: Wu
authors.forename: Jia-Jie
authors.initials: JJ
authors.lastname: Zhang
authors.forename: Zhi-Qin
authors.initials: ZQ
authors.lastname: Li
authors.forename: Shu-Guang
authors.initials: SG
authors.lastname: Wu
mesh_terms: D017836:Agkistrodon; D000818:Animals; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D012910:Snake Venoms / Q000737:chemistry*
chemical_list: D010455:Peptides; D010975:Platelet Aggregation Inhibitors; D012910:Snake Venoms