title: Diffuse optical tomography with spectral constraints and wavelength optimization.
abstract: We present an algorithm that explicitly utilizes the wavelength dependence of tissue optical properties for diffuse optical tomography. We have previously shown that the method gives superior separation of absorption and scattering. Here the technique is described and tested in detail, and optimum wavelength sets for a broad range of chromophore combinations are discovered and analyzed.
authors.affiliation: Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. corlua@dept.physics.upenn.edu
authors.forename: Alper
authors.initials: A
authors.lastname: Corlu
authors.forename: Regine
authors.initials: R
authors.lastname: Choe
authors.forename: Turgut
authors.initials: T
authors.lastname: Durduran
authors.forename: Kijoon
authors.initials: K
authors.lastname: Lee
authors.forename: Martin
authors.initials: M
authors.lastname: Schweiger
authors.forename: Simon R
authors.initials: SR
authors.lastname: Arridge
authors.forename: Elizabeth M C
authors.initials: EM
authors.lastname: Hillman
authors.forename: Arjun G
authors.initials: AG
authors.lastname: Yodh
mesh_terms: D000465:Algorithms; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D003198:Computer Simulation; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008954:Models, Biological; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity; D013053:Spectrophotometry / Q000379:methods*; D041622:Tomography, Optical / Q000379:methods*
chemical_list: D014408:Biomarkers, Tumor; D006454:Hemoglobins