title: Pediatric refractory partial status epilepticus responsive to topiramate.
abstract: Topiramate was safely administered to two young children with refractory partial status epilepticus via nasogastric tube in rapid titration up to a very high total daily dose. An excellent clinical response occurred in both cases. Reaching high daily doses of topiramate within days allowed for safe discontinuation of other antiepileptic drugs in both patients. Given the high efficacy of rapidly titrated topiramate in our patients, this medication may be useful in some cases of pediatric refractory partial status epilepticus. However, more clinical studies on this therapeutic approach are needed to establish the precise role of topiramate in status epilepticus in children.
authors.affiliation: Pediatric Neurology Unit, Wolfson Medical Center, Holon, Israel.
authors.forename: Lubov
authors.initials: L
authors.lastname: Blumkin
authors.forename: Tally
authors.initials: T
authors.lastname: Lerman-Sagie
authors.forename: Tzion
authors.initials: T
authors.lastname: Houri
authors.forename: Eli
authors.initials: E
authors.lastname: Gilad
authors.forename: Andrea
authors.initials: A
authors.lastname: Nissenkorn
authors.forename: Mira
authors.initials: M
authors.lastname: Ginsberg
authors.forename: Nathan
authors.initials: N
authors.lastname: Watemberg
mesh_terms: D000927:Anticonvulsants / Q000008:administration & dosage*; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005260:Female; D005632:Fructose / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D013226:Status Epilepticus / Q000188:drug therapy*; D000077236:Topiramate
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose