Dynamic aspects of presynaptic calcium currents mediating synaptic transmission.
Ca2+ entry through voltage-gated Ca2+ channels (VGCC) triggers transmitter release. Direct recording of Ca2+ currents from the calyx of Held nerve terminal revealed that presynaptic VGCCs undergo various modulations via presynaptic G protein-coupled receptors (GPCRs), Ca2+-binding proteins and a developmental switch of their alpha1 subunits. Dynamic changes of presynaptic VGCCs alter synaptic efficacy, thereby contributing to a variety of modulations of the CNS function.
Takahashi
Tomoyuki
T
Department of Neurophysiology, University of Tokyo Graduate School of Medicine, Tokyo 113-0033, Japan. ttakahas-tky@umin.ac.jp
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000502:physiology*; D017729:Presynaptic Terminals / Q000378:metabolism*; D009435:Synaptic Transmission / Q000502:physiology*
D015220:Calcium Channels; D002118:Calcium