The influence of genetic variation in oxidative stress genes on human noise susceptibility.
Noise induced hearing loss (NIHL) is a complex disease caused by an interaction between genetic and environmental factors. Damage in the cochlea as a result of noise exposure appears to be mediated by reactive oxygen species (ROS). To investigate whether genetic variation in the human protective antioxidant system is associated with high or low susceptibility to NIHL, genetic polymorphisms derived from genes involved in the oxidative stress response were analysed in the 10% most susceptible and 10% most resistant extremes of 1200 Swedish noise-exposed workers. The genetic polymorphisms included 2 deletion polymorphisms for the GSTM1 and GSTT1 gene, and 14 SNPs derived from the CAT, SOD, GPX, GSR and GSTP1 genes. No significant differences were found between susceptible and resistant groups, providing no support for a major role of genetic variation of antioxidant enzymes in the susceptibility to NIHL.
Carlsson
Per-Inge
PI
Department of Audiology, Orebro University Hospital, Sweden. per-inge.carlsson@orebroll.se
Van Laer
Lut
L
Borg
Erik
E
Bondeson
Marie-Louise
ML
Thys
Melissa
M
Fransen
Erik
E
Van Camp
Guy
G
D001299:Audiometry; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase / Q000235:genetics; D006317:Hearing Loss, Noise-Induced / Q000235:genetics*; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D018384:Oxidative Stress / Q000235:genetics*; D010088:Oxidoreductases / Q000235:genetics; D020641:Polymorphism, Single Nucleotide
D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; D007527:Isoenzymes; D010088:Oxidoreductases; C496556:GSTP1 protein, human; C412602:glutathione S-transferase Mu 2