title: Mucosal vaccination with an attenuated maedi-visna virus clone.
abstract: Four sheep were infected intratracheally with an attenuated molecular clone of maedi-visna virus (MVV). All four became infected. Ten months later these sheep were challenged intratracheally with a genetically similar but pathogenic clone of MVV. Four unvaccinated sheep were infected simultaneously. All sheep became infected by the challenge virus. The vaccinated sheep were not protected against superinfection with the challenge clone. However, virus was isolated more frequently from the blood of the unvaccinated controls than of the vaccinated animals and ten times more frequently from lungs of unvaccinated sheep than from lungs of vaccinated sheep at sacrifice, indicating partial protection.
authors.affiliation: Institute for Experimental Pathology, University of Iceland, Keldur v/Vesturlandsveg, Reykjavik, Iceland. gpet@hi.is
authors.forename: Gudmundur
authors.initials: G
authors.lastname: Pétursson
authors.forename: Sigrídur
authors.initials: S
authors.lastname: Matthíasdóttir
authors.forename: Vilhjálmur
authors.initials: V
authors.lastname: Svansson
authors.forename: Valgerdur
authors.initials: V
authors.lastname: Andrésdóttir
authors.forename: Gudmundur
authors.initials: G
authors.lastname: Georgsson
authors.forename: Agnes H
authors.initials: AH
authors.lastname: Martin
authors.forename: Gudrún
authors.initials: G
authors.lastname: Agnarsdóttir
authors.forename: Eygló
authors.initials: E
authors.lastname: Gísladóttir
authors.forename: Steinunn
authors.initials: S
authors.lastname: Arnadóttir
authors.forename: Svava
authors.initials: S
authors.lastname: Högnadóttir
authors.forename: Stefán Ragnar
authors.initials: SR
authors.lastname: Jónsson
authors.forename: Olafur S
authors.initials: OS
authors.lastname: Andrésson
authors.forename: Sigurbjörg
authors.initials: S
authors.lastname: Torsteinsdóttir
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis / Q000096:biosynthesis; D003001:Cloning, Molecular; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D018928:Immunity, Mucosal / Q000276:immunology*; D017403:In Situ Hybridization; D012756:Sheep; D015163:Superinfection / Q000517:prevention & control; D014613:Vaccines, Attenuated / Q000276:immunology; D019562:Viral Load; D014765:Viral Vaccines / Q000276:immunology*; D016182:Visna / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D014790:Visna-maedi virus / Q000276:immunology* / Q000302:isolation & purification
chemical_list: D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines