title: Introduction: neurobiological impact of environmental estrogens.
abstract: This paper provides an introduction to a special issue dedicated to the action of environmental estrogens on neural circuits and behavior. The problem of endocrine disrupting chemicals (EDCs), i.e. chemicals that have the capacity to interfere with the endocrine system, has gained increasing attention as it has become clear that these environmental contaminants may be active in humans, as well as in wildlife and domestic animal species. The majority of the early investigations were aimed at the discovery of the toxicological effects of the EDCs, but biomedical observations were among some of the first indications that estrogenic compounds may exert deleterious effects, even some time after exposure. The data derived from women exposed prenatally to diethylstilbesterol provided powerful evidence for long-term effects and endocrine disruption associated with selected compounds. The examination of wild animal populations exposed to industrial chemicals showed that the chemical exposure, though nonlethal, left the individual impaired or even incapable of reproducing. Among the multiple targets of the action of EDCs, several researches performed in recent years have investigated subtle modifications of the animal behaviors (reproductive, aggressive) that are likely to be related to alterations of specific neural pathways. We have, therefore, focused here on the behavioral studies as one of the more powerful tools to investigate EDCs effects on specific neural circuits.
authors.affiliation: Laboratory of Neuroendocrinology, Rita Levi Montalcini Center for Brain Repair, Department of Anatomy, University of Torino, c.so M. D'Azeglio 52, I-10126 Torino, Italy. giancarlo.panzica@unito.it
authors.forename: G C
authors.initials: GC
authors.lastname: Panzica
authors.forename: C
authors.initials: C
authors.lastname: Viglietti-Panzica
authors.forename: M A
authors.initials: MA
authors.lastname: Ottinger
mesh_terms: D000818:Animals; D001519:Behavior / Q000187:drug effects; D004703:Endocrine System / Q000187:drug effects*; D004785:Environmental Pollutants / Q000633:toxicity*; D004967:Estrogens / Q000633:toxicity*; D005260:Female; D006801:Humans; D008297:Male; D009415:Nerve Net / Q000187:drug effects; D009446:Neurobiology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
chemical_list: D004785:Environmental Pollutants; D004967:Estrogens