Effect of piroxicam, metamizol, and S-adenosylmethionine in a murine model of experimental trichomoniasis.
Biological effects of piroxicam, metamizol, and S-adenosylmethionine (S-AMET) have been tested in NMRI mice infected intraperitoneally with Trichomonas vaginalis. An intraperitoneal treatment during ten preinfection days with piroxicam (10 mg/Kg/day), or metamizol (275 mg/Kg/day), but not with S-AMET (117 mg/Kg/day) induced a significant decrease of abdominal lesions and mortality, assessed by means of a pathogenicity index. The trichomonicidal activity of piroxicam, metamizol, and S-AMET was tested in vitro at the concentration of 300 microM, but found ineffective. These assays have shown the usefulness of the experimental trichomoniasis model for the study of the immunomodulating activity of synthetic drugs.
Nogal-Ruiz
J J
JJ
Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain. jjnogal@yahoo.es
Gómez-Barrio
A
A
Escario
J A
JA
Montero-Pereira
D
D
Martínez-Fernández
A R
AR
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use; D001201:Ascites; D004177:Dipyrone / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D051379:Mice; D008815:Mice, Inbred Strains; D010894:Piroxicam / Q000494:pharmacology* / Q000627:therapeutic use; D011897:Random Allocation; D012436:S-Adenosylmethionine / Q000494:pharmacology* / Q000627:therapeutic use; D016896:Treatment Outcome; D014247:Trichomonas Vaginitis / Q000188:drug therapy*; D014246:Trichomonas vaginalis / Q000187:drug effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; D004177:Dipyrone; D012436:S-Adenosylmethionine