title: Carcinosarcoma of the prostate: two cases with distinctive morphologic and immunohistochemical findings.
abstract: Carcinosarcomas (CS) of the prostate are very uncommon neoplasms defined by the admixture of malignant epithelial and mesenchymal components. We describe here two new examples of CS in two patients aged 66 and 77 years, the first without previous history of prostate adenocarcinoma and the second with a 5-year history of acinar type prostate adenocarcinoma. The diagnosis of CS was made on the cystoprostatectomy specimen in the first case and transurethral resection in the second case. Both biphasic tumours exhibited papillary areas of ductal differentiation and conventional adenocarcinoma in the epithelial component, as well as malignant fibrous histiocytoma and angiosarcomatous areas in the first case and solid, poorly differentiated epithelial areas with neuroendocrine features in the second case. Immunohistochemistry revealed over-expression of c-erb B2 in the papillary epithelial component of both cases, whereas the solid undifferentiated epithelial areas in the second patient expressed c-kit, CD10 and synaptophysin, thus conforming a very undifferentiated cell population. The angiosarcomatous component of the first case expressed CD31 and CD10. The clinical course of the cases was divergent; the first patient is free of disease after radical surgery and adjuvant therapy and the other died 5 months after the diagnosis of CS, having already developed liver metastases.
authors.affiliation: Department of Pathology, Hospital Clinic, C/Villarroel 170, 08036 Barcelona, Spain.
authors.forename: Noelia
authors.initials: N
authors.lastname: Perez
authors.forename: Mireia
authors.initials: M
authors.lastname: Castillo
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Santos
authors.forename: David
authors.initials: D
authors.lastname: Truan
authors.forename: Rafael
authors.initials: R
authors.lastname: Gutierrez
authors.forename: Agustin
authors.initials: A
authors.lastname: Franco
authors.forename: Antonio
authors.initials: A
authors.lastname: Palacin
authors.forename: Josep Antoni
authors.initials: JA
authors.lastname: Bombi
authors.forename: Elias
authors.initials: E
authors.lastname: Campo
authors.forename: Pedro L
authors.initials: PL
authors.lastname: Fernandez
mesh_terms: D000368:Aged; D015415:Biomarkers; D001707:Biopsy, Needle; D002296:Carcinosarcoma / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D015260:Neprilysin / Q000032:analysis; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D020728:Transurethral Resection of Prostate; D014463:Ultrasonography
chemical_list: D015415:Biomarkers; D007633:Keratins; D015260:Neprilysin; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D017430:Prostate-Specific Antigen; D019009:Proto-Oncogene Proteins c-kit; D018719:Erb-b2 Receptor Tyrosine Kinases; C400901:CAM 5.2 antigen