[PPARs and fibrosis].
Inflammation is associated with fibrosis. Angiotensin II-stimulated growth of fibroblasts and an increase in collagen type I synthesis are important component of the cardiac remodeling process in hypertension and chronic ischemia. AngII has been shown to enhance production of reactive oxygen species (ROS) via stimulation of nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase. Recent studies have proposed that stimulation of ROS production by AngII may constitute a means by which this humoral factor contributes to development of tissue injury in organs such as blood vessels, kidney, and the heart. Published studies have shown that PPARgamma ligands can attenuate the expression or activity of NADPH oxidase subunits. Furthermore, it has been shown that PPARs inhibits inflammation by blocking the activation of redox-sensitive transcription factor NFkappaB. Although there is much still to learn about the link of inflammation and fibrosis, PPARs are potential therapeutic targets for treating cardiac fibrosis and perivascular fibrosis.
Kurabayashi
Masahiko
M
Department of Medicine and Biological Science, Gunma University Graduate School of Medicine.
D017667:Adipocytes / Q000502:physiology; D000450:Aldosterone / Q000502:physiology; D000818:Animals; D055513:Connective Tissue Growth Factor; D005355:Fibrosis / Q000503:physiopathology*; D017874:Immediate-Early Proteins / Q000502:physiology; D007249:Inflammation / Q000503:physiopathology; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D051379:Mice; D019255:NADPH Oxidases / Q000378:metabolism; D047492:Peroxisome Proliferator-Activated Receptors / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000502:physiology
C526318:CCN2 protein, mouse; D017874:Immediate-Early Proteins; D036341:Intercellular Signaling Peptides and Proteins; D047492:Peroxisome Proliferator-Activated Receptors; D016212:Transforming Growth Factor beta; D055513:Connective Tissue Growth Factor; D000450:Aldosterone; D019255:NADPH Oxidases