title: Natural killer cell alloreactivity for leukemia therapy.
abstract: Donor-versus-recipient natural killer (NK) cell alloreactivity derives from a mismatch between donor NK clones, carrying specific inhibitory receptors for self MHC class I molecules, and MHC class I ligands on recipient cells. When faced with mismatched allogeneic targets, these donor NK clones sense the missing expression of self HLA class I alleles and mediate alloreactions. Transplantation from NK alloreactive haploidentical donors controls acute myeloid leukemia relapse and improves engraftment without causing graft-versus-host disease.
authors.affiliation: Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, 06122 Perugia, Italy.
authors.forename: Loredana
authors.initials: L
authors.lastname: Ruggeri
authors.forename: Antonella
authors.initials: A
authors.lastname: Mancusi
authors.forename: Katia
authors.initials: K
authors.lastname: Perruccio
authors.forename: Emanuela
authors.initials: E
authors.lastname: Burchielli
authors.forename: Massimo F
authors.initials: MF
authors.lastname: Martelli
authors.forename: Andrea
authors.initials: A
authors.lastname: Velardi
mesh_terms: D000818:Animals; D015234:HLA-A Antigens / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016219:Immunotherapy, Adoptive; D007694:Killer Cells, Natural / Q000276:immunology*; D007938:Leukemia / Q000628:therapy*; D051379:Mice; D014184:Transplantation, Homologous
chemical_list: D015234:HLA-A Antigens