Clonostachysins A and B, new anti-dinoflagellate cyclic peptides from a marine-derived fungus.
The two new anti-dinoflagellates, clonostachysins A and B, were obtained from a marine sponge derived fungus Clonostachys rogersoniana strain HJK9. Their chemical structures were determined by spectroscopic studies as highly N-methylated cyclic peptides of the nine amino acids. The absolute stereochemistry was elucidated by the advanced Marfey's method. Both clonostachysins A and B exhibited a selectively inhibitory effect on a dinoflagellate Prorocentrum micans at 30 microM, but had no effect on other microalgae and bacteria even at 100 microM.
Adachi
Kyoko
K
Marine Biotechnology Institute Co. Ltd., 3-75-1 Heita, Kamaishi-shi 026-0001, Japan. kyoko.adachi@mbio.jp
Kanoh
Kaneo
K
Wisespongp
Puntip
P
Nishijima
Miyuki
M
Shizuri
Yoshikazu
Y
D000818:Animals; D000981:Antiprotozoal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D001681:Biological Assay; D004141:Dinoflagellida / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010456:Peptides, Cyclic / Q000302:isolation & purification / Q000494:pharmacology*
D000981:Antiprotozoal Agents; D010456:Peptides, Cyclic; C500120:clonostachysin A; C500119:clonostachysin B