Homeostatic niche specification among naïve and activated B cells: a growing role for the BLyS family of receptors and ligands.
B lymphocyte homeostasis encompasses the establishment and maintenance of independently regulated niches, within which cells compete for viability promoting resources. The BLyS/BLyS receptor family controls the size and composition of these niches, by governing the selection and survival of most peripheral B cells. Moreover, different receptor-ligand sets from this family dominate the regulation of various B cell subsets. These observations suggest a model whereby the regulation of BLyS receptors by differentiative and stimulatory cues yield characteristic BLyS receptor signatures, thus specifying homeostatic niche and competitive advantage.
Crowley
Jenni E
JE
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 284 John Morgan Building, 36th And Hamilton Walk, Philadelphia, PA 19104-8062, USA.
Treml
Laura S
LS
Stadanlick
Jason E
JE
Carpenter
Erica
E
Cancro
Michael P
MP
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D008024:Ligands; D008213:Lymphocyte Activation; D051379:Mice; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism*
C120197:BLyS receptor; D008024:Ligands; D018124:Receptors, Tumor Necrosis Factor