title: [Intraoperative radical clot removal therapy using a bipolar irrigation system for prevention of cerebral vasospasm following subarachnoid hemorrhage].
abstract: To investigate cerebral vasospasm following subarachnoid hemorrhage (SAH), 65 cases were analyzed by the incidence of delayed ischemic neurological deficit (DIND). Eighty-four consecutive cases, who underwent surgery within 72 hours of SAH, were retrospectively analyzed. Sixty-five of these patients had diffuse subarachnoid hemorrhage in CT scan and had aneurysms of the anterior circulation. They were divided into two groups according to the operative procedure: Group A (35 cases) had radical clot removal therapy with urokinase in 5% glucose solutions using a bipolar irrigation system; Group B (30 cases) had conventional clot removal using manual irrigation. There were no significant differences between these two groups for age or pre-operative WFNS grade. The incidence of DIND was 17.1% in group A and 40.0% in groupB; this was a significant difference. Radical clot removal therapy was effective in preventing DIND due to vasospasm.
authors.affiliation: Department of Neurosurgery, Suishokai Murata Hospital, Osaka-city, Osaka, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Tsuruno
mesh_terms: D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000601:surgery; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D013345:Subarachnoid Hemorrhage / Q000601:surgery*; D007507:Therapeutic Irrigation / Q000379:methods; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use*; D020301:Vasospasm, Intracranial / Q000517:prevention & control*
chemical_list: D014568:Urokinase-Type Plasminogen Activator