[Fungal sepsis--therapeutical strategy].
The incidence of fungal infection as well as fungal sepsis has increased dramatically during the last decade. Changes of local microbial flora after broad-spectrum antibiotic therapy allow overgrowth of Candida species. Prophylactic strategies to lower fungal infection and sepsis include adequate and restrictive antibiotic therapy. Concerning the treatment of the septic syndrome, supportive as well as adjunctive strategies like early-goal-directed cardiovascular therapy, hydrocortisone replacement therapy, intense insulin application to achieve normoglycemia as well as the application of activated Protein C besides a consequent source control regimen and standard intensive care therapy, are able to improve significantly the outcome of septic patients.
Staubach
K H
KH
Klinik für Chirurgie, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, D-23538 Lübeck, Germany.
D000935:Antifungal Agents / Q000627:therapeutic use*; D018890:Chemoprevention; D006801:Humans; D009181:Mycoses / Q000188:drug therapy / Q000382:microbiology; D018805:Sepsis / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control
D000935:Antifungal Agents