title: SNPLINK: multipoint linkage analysis of densely distributed SNP data incorporating automated linkage disequilibrium removal.
abstract: SNPLINK is a Perl script that performs full genome linkage analysis of high-density single nucleotide polymorphism (SNP) marker sets. The presence of linkage disequilibrium (LD) between closely spaced SNP markers can falsely inflate linkage statistics. SNPLINK removes LD from the marker sets in an automated fashion before carrying out linkage analysis. SNPLINK can compute both parametric and non-parametric statistics, utilizing the freely available Allegro and Merlin software. Graphical outputs of whole genome multipoint linkage statistics are provided allowing comparison of results before and after the removal of LD.
authors.affiliation: Section of Cancer Genetics, Institute of Cancer Research 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.
authors.forename: Emily L
authors.initials: EL
authors.lastname: Webb
authors.forename: Gabrielle S
authors.initials: GS
authors.lastname: Sellick
authors.forename: Richard S
authors.initials: RS
authors.lastname: Houlston
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D002874:Chromosome Mapping / Q000379:methods*; D003198:Computer Simulation; D004252:DNA Mutational Analysis / Q000379:methods*; D015810:Linkage Disequilibrium / Q000235:genetics*; D008957:Models, Genetic; D015233:Models, Statistical; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012984:Software; D016008:Statistical Distributions; D014584:User-Computer Interface