[Anti-tumor effects of ampelopsin on human lung cancer GLC-82 implanted in nude mice].
OBJECTIVE
To investigate the effects of ampelopsin on the growth of human lung cancer cell line GLC-82 in nude mice.


METHODS
GLC-82 cells were inoculated into the armpit of nude mice to establish lung cancer model. Then the BALB/C nude mice 6 with xenograft tumor were randomized into 6 groups. Ampelopsin was administered at 3 dosages by intraperitoneal injection daily. The anti-tumor effect of ampelopsin was evaluated on tumor volume, relative tumor volume, tumor weight, relative tumor proliferative rale, and tumor growth curve.


RESULTS
At the 250 mg/kg dose of ampelopsin, the growth inhibition of the transplant tumor was 35.5% (P < 0.01) and 37.1% (P < 0.01), and the relative tumor proliferative rate was 55.24% (P < 0.01) and 57.71% (P < 0.05), respectively in two independent experiments by compared with the normal saline control.


CONCLUSIONS
Ampelopsin appears to be a potent anti-tumor agent that was firstly discovered in the transplant human lung cancer cell line GLC-82 in nude mice in vivo.
Zeng
Sa
S
School of pharmaceutical Sciences, Sun Yat-sen University, Guangzhou.
Liu
Deyu
D
Ye
Yanli
Y
Wang
Liangui
L
Wang
Wei
W
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D010946:Plants, Medicinal / Q000737:chemistry*; D013997:Time Factors
D000970:Antineoplastic Agents; D005419:Flavonoids; C106407:ampelopsin