title: Comparison of enzymatic and microbiological gentamicin assays.
abstract: The correlation coefficient between the rapid enzymatic and the overnight microbiological assays for 211 urine and serum specimens was 0.96. The 95% confidence limits yielded a correlation coefficient between 0.92 and 0.98. Both methods tended to underestimate the amount of a gentamicin added to urine. When only serum samples were considered, the predicted value obtained from the linear regression analysis of either method was within 0.57 mug/ml 99% of the time. This high degree of positive correlation will permit safe rapid adjustment of individualized patient gentamicin dosages.
authors.forename: A L
authors.initials: AL
authors.lastname: Smith
authors.forename: J A
authors.initials: JA
authors.lastname: Waitz
authors.forename: D H
authors.initials: DH
authors.lastname: Smith
authors.forename: E M
authors.initials: EM
authors.lastname: Oden
authors.forename: B B
authors.initials: BB
authors.lastname: Emerson
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis*; D005839:Gentamicins / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D009713:Nucleotidyltransferases / Q000378:metabolism; D012044:Regression Analysis
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D009713:Nucleotidyltransferases; C020565:gentamicin 2''-nucleotidyltransferase