Computational multiple steady states for enzymatic esterification of ethanol and oleic acid in an isothermal CSTR.
The capacity of complex biochemical reaction networks (consisting of 11 coupled non-linear ordinary differential equations) to show multiple steady states, was investigated. The system involved esterification of ethanol and oleic acid by lipase in an isothermal continuous stirred tank reactor (CSTR). The Deficiency One Algorithm and the Subnetwork Analysis were applied to determine the steady state multiplicity. A set of rate constants and two corresponding steady states are computed. The phenomena of bistability, hysteresis and bifurcation are discussed. Moreover, the capacity of steady state multiplicity is extended to the family of the studied reaction networks.
Ho
Pang-Yen
PY
Department of Chemical Engineering, National United University, Miaoli, Taiwan, ROC. pyho@nuu.edu.tw
Chuang
Guo-Syong
GS
Chao
An-Chong
AC
Li
Hsing-Ya
HY
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003198:Computer Simulation; D004951:Esterification; D000431:Ethanol / Q000737:chemistry*; D007700:Kinetics; D008049:Lipase / Q000737:chemistry*; D008956:Models, Chemical; D019301:Oleic Acid / Q000737:chemistry*; D013696:Temperature
D019301:Oleic Acid; D000431:Ethanol; D008049:Lipase