title: A concise route to the azaspirodecane moiety of halichlorine and structurally related alkaloids.
abstract: [reaction: see text] A tandem Michael addition-enolate alkylation followed by Dieckmann cyclization and Beckmann rearrangement provided the corresponding [5.4.0] azaspirobicyclodecane, a key intermediate in our synthetic route to the marine alkaloid halichlorine (1).
authors.affiliation: Instituto de Química, Universidade Estadual de Campinas, C. P. 6154,13084-971, Campinas, SP, Brazil.
authors.forename: Andrea L
authors.initials: AL
authors.lastname: de Sousa
authors.forename: Ronaldo A
authors.initials: RA
authors.lastname: Pilli
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis*; D000818:Animals; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D013141:Spiro Compounds; C412666:halichlorine