title: Urinary excretion of biopyrrins, oxidative metabolites of bilirubin, increases in patients with psychiatric disorders.
abstract: Several authors have suggested that psychological stress induces the production of reactive oxygen species (ROS). Several studies have supported the idea that bilirubin exerts antioxidative effects in vivo, and it was reported psychological stress provokes bilirubin oxidation in vivo [Yamaguchi T., Shioji I., Sugimoto A., Yamaoka M., 2002. Psychological stress increases bilirubin metabolites in human urine. Biochem. and Biophys. Res. Commun. 293, 517-520]. We investigated whether the concentration of bilirubin oxidative metabolites (biopyrrins) is increased in urine from patients with psychiatric disorders. The concentration of biopyrrins in urine of 25 patients with psychiatric disorders (schizophrenia, 15; depression, 10) was compared with 96 healthy volunteers. The concentrations of biopyrrins, as measured by enzyme-linked immunosorbent assay, were normalized to the urinary concentration of creatinine. The concentration of biopyrrins in patients with psychiatric disorders (schizophrenia and depression) was significantly higher than that of healthy volunteers. In schizophrenia, biopyrrins levels correlated with scores of the Brief Psychiatric Rating Scale (BPRS), and in depression, biopyrrins levels correlated with scores of the Hamilton Depression Rating Scale (HAM-D). These finding suggest that psychotic states are associated with an increase in the oxidative metabolites of bilirubin in human urine.
authors.affiliation: Department of Psychiatry, Shimane University School of Medicine, 89-1 Enyacho, Izumo 693-8501, Japan. miyanyan@med.shimane-u.ac.jp
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Miyaoka
authors.forename: Rei
authors.initials: R
authors.lastname: Yasukawa
authors.forename: Hideaki
authors.initials: H
authors.lastname: Yasuda
authors.forename: Maiko
authors.initials: M
authors.lastname: Shimizu
authors.forename: Soichi
authors.initials: S
authors.lastname: Mizuno
authors.forename: Tsuruhei
authors.initials: T
authors.lastname: Sukegawa
authors.forename: Takuji
authors.initials: T
authors.lastname: Inagaki
authors.forename: Jun
authors.initials: J
authors.lastname: Horiguchi
mesh_terms: D000328:Adult; D001663:Bilirubin / Q000652:urine*; D015415:Biomarkers / Q000652:urine; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000652:urine*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology; D011569:Psychiatric Status Rating Scales; D017382:Reactive Oxygen Species; D012559:Schizophrenia / Q000652:urine; D013315:Stress, Psychological / Q000523:psychology / Q000652:urine
chemical_list: D015415:Biomarkers; D017382:Reactive Oxygen Species; D001663:Bilirubin