Novel film modifiers to alter the physical properties of composite ethylcellulose films.
OBJECTIVE
Polyvinylpyrrolidone (PVP), molecular-composite PVP, and Plasdone S-630 copolyvidonum are potential polymeric film modifiers for achieving improved drug release. The aim of this study was to investigate how these polymeric additives would affect the physicomechanical properties of composite ethylcellulose films.


METHODS
The miscibility of these polymeric additives with ethylcellulose was determined from the differential scanning calorimetry (DSC) thermograms of various polymer blends formed from organic solvents. It was found that ethylcellulose (EC) was miscible with the polymeric additives up to a concentration of 50%. Ten percent to 30% w/w polymeric additives were then added to aqueous ethylcellulose dispersion to form composite films. The morphology, film transparency, dynamic mechanical analysis (DMA) thermograms, and mechanical properties of the composite ethylcellulose films were studied. In addition, puncture strength and % elongation of the dry and wet films were also compared from indentation test.


RESULTS
Significant reduction and change in film transparency and morphology was obtained for EC films blended with PVP of higher molecular weight (MW). The composite EC films also showed higher Tg, greater elastic modulus, tensile and puncture strength depending on the concentration and type of additives present.


CONCLUSIONS
The interaction between ethylcellulose and the polymeric additives is dependent on the MW and concentration of additives. The composite films offer new opportunities for the use of ethyl-cellulose as modified release coatings for dosage forms.
Chan
Lai Wah
LW
Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore 117543, Singapore.
Ong
Kang Teng
KT
Heng
Paul Wan Sia
PW
D002482:Cellulose / Q000031:analogs & derivatives* / Q000032:analysis* / Q000737:chemistry*; D011108:Polymers / Q000032:analysis* / Q000737:chemistry*
D011108:Polymers; C013517:ethyl cellulose; D002482:Cellulose