title: In vivo induction of sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) by lynestrenol.
abstract: Genotoxicity study of synthetic progestin lynestrenol, was carried out on mouse bone marrow cells using sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) as parameters. Lynestrenol was studied at three different doses (6.87, 13.75 and 27.50 mg/kg body wt.). SCE and CA increased significantly as compared to normal control when treated with lynestrenol at 13.75 and 27.50 mg/kg body wt. The present results suggest that lynestrenol has both a genotoxic and cytotoxic effects in mouse bone marrow cells.
authors.affiliation: Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh 202 002, India. yasir_hasansiddique@rediffmail.com
authors.forename: Yasir Hasan
authors.initials: YH
authors.lastname: Siddique
authors.forename: Mohammad
authors.initials: M
authors.lastname: Afzal
mesh_terms: D000818:Animals; D001835:Body Weight; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D002869:Chromosome Aberrations; D003280:Contraceptives, Oral, Synthetic / Q000494:pharmacology; D004249:DNA Damage; D005260:Female; D008234:Lynestrenol / Q000494:pharmacology*; D051379:Mice; D012854:Sister Chromatid Exchange
chemical_list: D003280:Contraceptives, Oral, Synthetic; D008234:Lynestrenol