Promoter polymorphism of second tryptophan hydroxylase isoform (TPH2) in schizophrenia and suicidality.
Allele and haplotype frequencies of a promoter polymorphism in the gene encoding tryptophan hydroxylase (TPH2) did not differ in 83 suicidal schizophrenic patients compared with 170 non-suicidal schizophrenic patients. These findings suggest that these 5' marker haplotypes in the TPH2 gene do not influence suicidal behavior in schizophrenia.
De Luca
Vincenzo
V
Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Street, R-30, Toronto, Ontario, Canada M5T 1R8. Vincenzo_Deluca@camh.net
Voineskos
Daphne
D
Wong
Gregory W H
GW
Shinkai
Takahiro
T
Rothe
Claudia
C
Strauss
John
J
Kennedy
James L
JL
D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D005260:Female; D005819:Genetic Markers; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D020033:Protein Isoforms / Q000235:genetics; D012559:Schizophrenia / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics; D013406:Suicide, Attempted / Q000706:statistics & numerical data*; D014365:Tryptophan Hydroxylase / Q000235:genetics* / Q000378:metabolism*
D005819:Genetic Markers; D020033:Protein Isoforms; C494784:TPH2 protein, human; D014365:Tryptophan Hydroxylase