Determination of water compartments in rat myocardium using combined D-T1 and T1-T2 experiments.
We have used combined D-T1 and T1-T2 correlation experiments to explore water compartments in rat heart tissue (myocardium). The results show that two main compartments can be identified, which we assign to extracellular (ec) and intracellular (ic) water. The exchange rate of water across the cell membrane was found to be on the order of 0.1 Hz. In addition, the T1-T2 correlation measurements indicate that the ic compartment contain two T2 populations.
Seland
John Georg
JG
Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, N-7489 Trondheim, Norway. john.seland@medisin.ntnu.no
Bruvold
Morten
M
Anthonsen
Henrik
H
Brurok
Heidi
H
Nordhøy
Wibeke
W
Jynge
Per
P
Krane
Jostein
J
D000818:Animals; D001825:Body Fluid Compartments; D001834:Body Water / Q000737:chemistry*; D002463:Cell Membrane Permeability; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009206:Myocardium / Q000737:chemistry*; D016062:Porosity; D051381:Rats