Possible association between the gamma-aminobutyric acid type B receptor 1 (GABBR1) gene and schizophrenia.
Schizophrenia (SCZ) is a severe neuropsychiatric disorder with a genetic component. The major inhibitory GABA-(gamma-aminobutyric acid) ergic system may be involved. The GABA type B receptor 1 (GABBR1) gene has been localized to 6p21.3, a region linked to SCZ. We therefore investigated five polymorphisms (A-7265G, C10497G, Ser-491-Ser-T1473C, Phe-659-Phe-T1977C, and 3'-UTR A33795G substitutions) in the GABBR1 gene in a sample of 101 DSM-IV SCZ probands and their families, 150 unrelated affected individuals matched with 150 healthy controls, using the transmission disequilibrium test (TDT) and case-control analysis. We did not observe biased transmission of alleles in any of the polymorphisms individually and haplotypes within the gene to SCZ probands. However, a weak significant difference was observed in the A-7265G polymorphism between the allelic frequency (chi2 = 4.310, P = 0.038) and a trend was observed between the genotype frequency (chi2 = 4.970, 2 df, P = 0.083) of SCZ individuals and controls. Further investigations of the role of GABBR1 in SCZ are warranted.
Zai
Gwyneth
G
Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, ON, Canada M5T 1R8. gwyneth_zai@camh.net
King
Nicole
N
Wong
Gregory W H
GW
Barr
Cathy L
CL
Kennedy
James L
JL
D020413:3' Untranslated Regions / Q000235:genetics; D000328:Adult; D000483:Alleles; D019943:Amino Acid Substitution; D016022:Case-Control Studies; D004247:DNA / Q000235:genetics; D005091:Exons / Q000235:genetics; D005190:Family; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011569:Psychiatric Status Rating Scales; D018080:Receptors, GABA-B / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology
D020413:3' Untranslated Regions; D005819:Genetic Markers; D018080:Receptors, GABA-B; D004247:DNA