Neural integrator function in murine CACNA1A mutants.
Time constants of gaze holding are shortened in rocker and tottering mice, two strains whose cerebellar dysfunction stems from genetic alterations of the P/Q calcium channel. The finding suggests that in mice as in primates, the cerebellum contributes to the function of the neural integrator. Studying CACNA1A mutants may elucidate how cerebellar signals support gaze holding.
Stahl
John S
JS
Department of Neurology, Case Western Reserve University, 11100 Euclid Ave., Cleveland, OH 44106-5040, USA. jss6@case.edu
James
Robert A
RA
D000818:Animals; D020864:Calcium Channels, N-Type; D020865:Calcium Channels, P-Type / Q000235:genetics*; D020907:Calcium Channels, Q-Type / Q000235:genetics*; D002524:Cerebellar Ataxia / Q000235:genetics; D002531:Cerebellum / Q000502:physiology / Q000503:physiopathology; D005403:Fixation, Ocular; D051379:Mice; D009154:Mutation; D011323:Primates; D015398:Signal Transduction
D020864:Calcium Channels, N-Type; D020865:Calcium Channels, P-Type; D020907:Calcium Channels, Q-Type