title: Intracellular immunity to HIV-1: newly defined retroviral battles inside infected cells.
abstract: Studies of the human immunodeficiency virus type 1 (HIV-1) continue to enrich eukaryotic biology and immunology. Recent advances have defined factors that function after viral entry and prevent the replication of proviruses in the infected cell. Some of these attack directly viral structures whereas others edit viral genetic material during reverse transcription. Together, they provide strong and immediate intracellular immunity against incoming pathogens. These processes also offer a tantalizing glimpse at basic cellular mechanisms that might restrict the movement of mobile genetic elements and protect the genome.
authors.affiliation: Department of Medicine, Rosalind Russell Arthritis Research Center, University of California, San Francisco, CA 94143-0703, USA. yonghui@itsa.ucsf.edu
authors.forename: Yong-Hui
authors.initials: YH
authors.lastname: Zheng
authors.forename: B Matija
authors.initials: BM
authors.lastname: Peterlin
mesh_terms: D000818:Animals; D000090103:Antiviral Restriction Factors; D002352:Carrier Proteins / Q000378:metabolism / Q000494:pharmacology*; D002460:Cell Line; D043525:Cytosine Deaminase / Q000378:metabolism / Q000494:pharmacology*; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D000070584:Tripartite Motif Proteins; D044767:Ubiquitin-Protein Ligases; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000090103:Antiviral Restriction Factors; D002352:Carrier Proteins; D000070584:Tripartite Motif Proteins; C477346:TRIM5 protein, human; D044767:Ubiquitin-Protein Ligases; D043525:Cytosine Deaminase