Bio-adhesive surfaces to promote osteoblast differentiation and bone formation.
Binding of integrin adhesion receptors to extracellular matrix components, such as fibronectin and type I collagen, activates signaling pathways directing osteoblast survival, cell-cycle progression, gene expression, and matrix mineralization. Biomimetic strategies exploit these adhesive interactions to engineer bio-inspired surfaces that promote osteoblast adhesion and differentiation, bone formation, and osseointegration. These emerging initiatives focus on directing integrin binding through presentation of bio-adhesive motifs derived from extracellular matrices. These biomolecular approaches provide promising strategies for the development of biologically active implants and grafting substrates for enhanced bone repair.
García
A J
AJ
Woodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, 315 Ferst Drive, 2314 Petit Biotechnology Building, Atlanta, GA 30332-0363, USA. andres.garcia@me.gatech.edu
Reyes
C D
CD
D040761:Biomimetic Materials / Q000737:chemistry*; D002448:Cell Adhesion / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D016326:Extracellular Matrix Proteins / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000502:physiology; D016348:Osseointegration / Q000502:physiology; D010006:Osteoblasts / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D016326:Extracellular Matrix Proteins; D016023:Integrins