title: [Influence of comorbidity on admission management and pharmacological treatment prescribed at discharge in acute myocardial infarction].
abstract: OBJECTIVE
  The management of cardiac ischemic patients differs depending on their comorbidity. The Charlson Index (ChI) and its adaptations are well established and widely used tools to quantify a patient comorbidity. The aim of this study is to evaluate the influence of comorbidity quantified by the ChI in the treatment administered at admission and in the pharmacological treatment prescribed at discharge in the setting of an acute myocardial infarction with and without ST segment elevation.
  
  
  METHODS
  We studied a total of 955 patients consecutively admitted in our hospital with the diagnosis of acute myocardial infarction. Comorbidity was obtained at the first day of admission applying the ChI. According to this value patients were classified from minor to major in 2 subgroups (ChI <or= 2, ChI >or= 2) and differences in the admission and discharge treatments between both groups were analyzed.
  
  
  RESULTS
  Patients admitted with acute myocardial infarction without ST segment elevation and ChI > 2 received less frequently betablockers at discharge, but there were no significant differences in the use of ACE inhibitors, calcium channel blockers or statins. In addition they were submitted less frequently to revascularization procedures or treadmills, and no differences were found in the use of echocardiograms. Patients with ST segment elevation and ChI > 2 were less frequently treated with betablockers or statins at discharge, and were submitted to less treadmills or echocardiograms; furthermore, in these patients, there were no significant differences in the use of ACE inhibitors, calcium channel blockers, thrombolytics or revascularization procedures.
  
  
  CONCLUSIONS
  Comorbidity quantified on admission by the ChI is an independent factor that modifies in-hospital and ambulatory management of patients with acute myocardial infarction. There is a lower use of invasive techniques as well as a lower prescription of betablockers at discharge in patients with greater comorbidity.
authors.affiliation: Servicio de Cardiología. Hospital Clínico Universitario, Valencia, España. lfacila@hotmail.com
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Fácila Rubio
authors.forename: Julio
authors.initials: J
authors.lastname: Núñez Villota
authors.forename: Vicente
authors.initials: V
authors.lastname: Bertomeu González
authors.forename: Juan
authors.initials: J
authors.lastname: Sanchís Fores
authors.forename: Vicent
authors.initials: V
authors.lastname: Bodi Peris
authors.forename: Luciano
authors.initials: L
authors.lastname: Consuegra Sánchez
authors.forename: Rafael
authors.initials: R
authors.lastname: Sanjuán Mañez
authors.forename: Angel
authors.initials: A
authors.lastname: Llácer Escorihuela
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000150:complications* / Q000188:drug therapy / Q000628:therapy*; D010343:Patient Admission; D010351:Patient Discharge; D011446:Prospective Studies