Trophoblast apoptosis is increased in women with evidence of TH1 immunity.
Interferon-gamma secretion from peripheral blood mononuclear cells (PBMCs) of women with unexplained recurrent spontaneous abortions was increased by trophoblast stimulation. Apoptosis was significantly increased in trophoblast cells cultured with the supernatant of PBMCs from women with evidence of T(H)1 immunity to trophoblast stimulation.
Lee
Jiae
J
Laboratory of Reproductive Medicine, Center for Recurrent Miscarriage and Infertility, Creation and Love Women's Hospital, Kwangju Institute of Science and Technology (K-JIST), 13-21 Gwangchun-Dong, Seo-Gu, Gwangju 502-210, Korea.
Choi
Bum-Chae
BC
Cho
Chunghee
C
Hill
Joseph A
JA
Baek
Kwang-Hyun
KH
Kim
Jeong-Wook
JW
D000026:Abortion, Habitual / Q000276:immunology*; D017209:Apoptosis / Q000276:immunology*; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D011247:Pregnancy; D018417:Th1 Cells / Q000276:immunology* / Q000378:metabolism; D014327:Trophoblasts / Q000276:immunology* / Q000473:pathology*
D007371:Interferon-gamma