Early cessation of triptorelin in in vitro fertilization: a double-blind, randomized study.
OBJECTIVE
To compare the efficacy of two early cessation protocols of triptorelin treatment in controlled ovarian hyperstimulation with the conventional long protocol in in vitro fertilization/intracytoplasmic sperm injection.


METHODS
A double-blind, randomized, multicenter study.


METHODS
Three Dutch hospitals.


METHODS
One hundred seventy-eight women randomized to one of three treatment groups at the start of stimulation.


METHODS
Midluteally started triptorelin administration was continued until the first day of hMG treatment (group S), or up to and including the fourth day of hMG treatment (group M) or the day of hCG injection (group L).


METHODS
Occurrence of a premature LH surge.


RESULTS
One premature LH surge was observed in group M but not in groups S and L. Both early cessation protocols (S and M) are at least as effective as the long protocol (L) with regard to the number of oocytes (11.1 and 10.3 vs. 9.3), number of embryos (7.3 and 6.5 vs. 5.5), and ongoing pregnancy rate (28% and 24% vs. 21%).


CONCLUSIONS
Early cessation of triptorelin on day 1 of hMG treatment in a midluteally started IVF protocol is as effective as the traditional long protocol in preventing a premature LH surge and results in similar fertility effects.
Simons
Arnold H M
AH
University Medical Center Groningen, PO Box 30.001, 0700 RB Groningen, The Netherlands. a.h.m.simons@og.umcg.nl
Roelofs
Henny J M
HJ
Schmoutziguer
Alex P E
AP
Roozenburg
Brigitte J
BJ
van't Hof-van den Brink
Eefje P
EP
Schoonderwoerd
Simon A
SA
D000293:Adolescent; D000328:Adult; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*; D007986:Luteinizing Hormone / Q000097:blood; D008186:Luteolytic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D008596:Menotropins / Q000008:administration & dosage; D006080:Ovarian Follicle / Q000166:cytology / Q000187:drug effects; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome; D020554:Sperm Injections, Intracytoplasmic; D017329:Triptorelin Pamoate / Q000008:administration & dosage* / Q000009:adverse effects
D005300:Fertility Agents, Female; D008186:Luteolytic Agents; D017329:Triptorelin Pamoate; D008596:Menotropins; D007986:Luteinizing Hormone