title: [Usefulness of extension of disease as a prognostic factor in relapsed prostate cancer patients of stage D].
abstract: OBJECTIVE
  The prognosis of prostate cancer has been evaluated by clinical stage or pathological grade. PSA parameters including PSA density and PSA doubling time have not always precisely reflected the prognosis of prostate cancer. The aim of this study was to evaluate PSA parameters and extension of disease (EOD) grade as prognostic factors for relapsed prostate cancer.
  
  
  METHODS
  The relationship between PSA parameters or EOD grade, and survival of 29 stage D patients with relapsed prostate cancer after initial hormone therapy was examined.
  
  
  RESULTS
  Only EOD grade was an independent prognostic factor, even for cause-specific survival period and survival period after relapse.
  
  
  CONCLUSIONS
  EOD grade was a significant prognostic factor, and in particular, very useful as a prognostic factor for patients with bone metastasis. PSA value was not always associated with tumor volume, and therefore it is not an independent prognostic factor.
authors.affiliation: Department of Urology, Yokohama City University Graduate School of Medicine.
authors.forename: Masaki
authors.initials: M
authors.lastname: Kawai
authors.forename: Hiroji
authors.initials: H
authors.lastname: Uemura
authors.forename: Hisashi
authors.initials: H
authors.lastname: Hasumi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Osada
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Ohta
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Miyoshi
authors.forename: Kunihisa
authors.initials: K
authors.lastname: Mikata
authors.forename: Hideki
authors.initials: H
authors.lastname: Oh-uchi
authors.forename: Shinpei
authors.initials: S
authors.lastname: Sugiura
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Fujinami
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Kubota
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality*; D009367:Neoplasm Staging; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology*; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D017430:Prostate-Specific Antigen