title: Electrical impedance scanning of thyroid nodules before thyroid surgery: a prospective study.
abstract: BACKGROUND
  Electrical impedance scanning (EIS) is a novel imaging technique based on differential electrical conductivity and capacitance of malignant and normal human tissues. The aim of this study was to evaluate the accuracy of EIS in the detection of thyroid malignancies.
  
  
  METHODS
  Patients with thyroid nodules scheduled for thyroid surgery were eligible for the study. Enrolled patients underwent EIS with a T-Scan 2000ED. Nodule location, size, and type (cystic vs. solid) measured by ultrasound, cytology results, thyroid conductivity, and capacitance calculated by EIS were recorded. EIS results were interpreted as positive or negative for malignancy and compared with final histopathology results. Study end points included EIS accuracy, sensitivity, specificity, negative and positive predictive values, and false-positive and false-negative rates.
  
  
  RESULTS
  Sixty-four patients were enrolled onto the study, and all underwent either lobectomy-isthmusectomy (20%) or total thyroidectomy (80%). The mean tumor diameter was 2.64 +/- 14.8 mm. Thyroid cancers were identified by histology in 30 patients (46.9%). There were 11 false-positive and four false-negative cases. The overall diagnostic accuracy of EIS was 76.6% (49 of 64 correct diagnoses). The sensitivity and specificity of EIS were 86.7% (26 of 30 true positive) and 67.6% (23 of 34 true negative), respectively. The corresponding positive and negative predictive values were 70.3% and 85.2%.
  
  
  CONCLUSIONS
  EIS is a potentially useful imaging modality for differentiating thyroid neoplasms. If these results are confirmed in large-scale trials, EIS may be an important part of the evaluation of thyroid nodules.
authors.affiliation: Department of Surgery, General Surgery Service, Walter Reed Army Medical Center, N.W., Washington, DC 20307, USA. alexander.stojadinovic@na.amedd.army.mil
authors.forename: Alexander
authors.initials: A
authors.lastname: Stojadinovic
authors.forename: Scott I
authors.initials: SI
authors.lastname: Fields
authors.forename: Craig D
authors.initials: CD
authors.lastname: Shriver
authors.forename: Sarah
authors.initials: S
authors.lastname: Lenington
authors.forename: Ron
authors.initials: R
authors.lastname: Ginor
authors.forename: George E
authors.initials: GE
authors.lastname: Peoples
authors.forename: Henry B
authors.initials: HB
authors.lastname: Burch
authors.forename: Tamar
authors.initials: T
authors.lastname: Peretz
authors.forename: Herbert R
authors.initials: HR
authors.lastname: Freund
authors.forename: Aviram
authors.initials: A
authors.lastname: Nissan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001823:Body Composition; D003952:Diagnostic Imaging / Q000379:methods; D017097:Electric Impedance; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D011446:Prospective Studies; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000601:surgery; D016606:Thyroid Nodule / Q000175:diagnosis; D013965:Thyroidectomy