title: Application of bis-acetylenic ketones in synthesis: one-pot preparation of the 1,2,4-triazepine and oxatriazaindenone cores.
abstract: Bis-acetylenic ketones were used to generate two heterocyclic templates. Two efficient one-pot procedures for the preparation of the triazepine and oxa-triazaindenone cores are described.
authors.affiliation: Centre for Synthesis and Chemical Biology (CSCB), Department of Pharmaceutical and Medicinal Chemistry, The Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Dublin, Ireland. madamo@rcsi.ie
authors.forename: Mauro F A
authors.initials: MF
authors.lastname: Adamo
authors.forename: Jack E
authors.initials: JE
authors.lastname: Baldwin
authors.forename: Robert M
authors.initials: RM
authors.lastname: Adlington
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis / Q000737:chemistry*; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D001381:Azepines / Q000138:chemical synthesis*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D007192:Indenes / Q000138:chemical synthesis*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000480:Alkynes; D001372:Aza Compounds; D001381:Azepines; D006571:Heterocyclic Compounds; D007192:Indenes; D007659:Ketones