title: Contribution of NTRK2 to the genetic susceptibility to anorexia nervosa, harm avoidance and minimum body mass index.
abstract: Anorexia nervosa (AN) and bulimia nervosa (BN) are eating disorders (ED) with complex genetic and environmental components. Genetic studies and animal models support the participation of brain-derived neurotrophic factor (BDNF) in the vulnerability to AN and BN. We investigated the genetic contribution of the BDNF-specific receptor neurotrophic tyrosine kinase receptor type 2 (NTRK2) to the susceptibility to ED. We have screened the entire NTRK2 gene in 91 patients with ED and have identified 14 single-nucleotide polymorphisms (SNPs). A population-based association study with six SNPs from the NTRK2 locus was performed in 164 ED patients and 121 controls. Significant evidence of association for markers -69C>G and IVS13+40G>A was detected. We also observed a strong association between the C-A-insC haplotype (-69/IVS13+40/2784-2785) and binge-eating/purging AN (ANP, P=0.006; OR=2.27), and a reduced frequency of haplotype G-A-delCl in BN patients (P=0.034; OR=0.6). The analysis of ED-related phenotypes revealed a clear association between NTRK2, high scores of Harm avoidance measured by the temperament and character inventory (TCI-R; P=0.003) and minimum body mass index (minBMI; P<0.001). Our data support a contribution of NTRK2 to the genetic susceptibility of ED, mainly ANP, and ED-related phenotypic traits, such as Harm avoidance and minBMI.
authors.affiliation: Genes and Disease Program, Center for Genomic Regulation, Barcelona, Catalonia, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Ribases
authors.forename: M
authors.initials: M
authors.lastname: Gratacos
authors.forename: A
authors.initials: A
authors.lastname: Badia
authors.forename: L
authors.initials: L
authors.lastname: Jimenez
authors.forename: R
authors.initials: R
authors.lastname: Solano
authors.forename: J
authors.initials: J
authors.lastname: Vallejo
authors.forename: F
authors.initials: F
authors.lastname: Fernandez-Aranda
authors.forename: X
authors.initials: X
authors.lastname: Estivill
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000235:genetics*; D001362:Avoidance Learning; D015992:Body Mass Index; D002032:Bulimia / Q000235:genetics; D002874:Chromosome Mapping; D005091:Exons; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007438:Introns; D008297:Male; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D018807:Polymorphism, Single-Stranded Conformational; D020813:Receptor, trkB / Q000235:genetics*; D012016:Reference Values; D012309:Risk-Taking
chemical_list: D020813:Receptor, trkB