Effect of dietary supplementation of chitosan and galacto-mannan-oligosaccharide on serum parameters and the insulin-like growth factor-I mRNA expression in early-weaned piglets.
The study was to determine effects of dietary supplementation of chitosan (COS) and galacto-mannan-oligosaccharides (GMOS) on some serum biochemical indices, serum growth hormone (GH) and insulin-like growth factor-I (IGF-I) levels, and hepatic and long gissimus muscle IGF-I mRNA expression in early-weaned piglets. Twenty six Duroc x Landrace x Yorkshire piglets at the age of 15 days were used. The piglets had access to creep feed during the suckling. Six piglets were sacrificed for sampling at the beginning of the study. The other 20 piglets were individually housed in metabolic cages and randomly allotted to four corn and soybean meal-based diets including the control group, the antibiotic group with 110 mg lincomycin/kg diet, the COS group containing 0.025% COS, and the GMOS group with 0.20% GMOS, respectively, in a 2-week feeding experiment. Blood urea nitrogen (BUN) level was reduced whereas serum total protein concentration was increased (P<0.05) in responses to the COS and GMOS supplementation. Dietary supplementation of COS and GMOS also increased (P<0.05) the serum GH and IGF-I levels along with enhanced hepatic and the muscle IGF-I mRNA abundance. Dietary supplementation of oligosaccharides such as COS and GMOS may improve growth and feed conversion efficiency by increasing plasma GH and IGF-I levels, in the early-weaned piglets.
Tang
Zhi-Ru
ZR
Key Laboratory of Subtropical Agro-ecology, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Hunan, P.O. Box 10, Changsha 410125, PR China.
Yin
Yu-Long
YL
Nyachoti
Charles M
CM
Huang
Rui-Lin
RL
Li
Tie-Jun
TJ
Yang
Chengbo
C
Yang
Xiao-Jian
XJ
Gong
Joshua
J
Peng
Jiang
J
Qi
De-Sheng
DS
Xing
Jian-Jun
JJ
Sun
Zhi-Hong
ZH
Fan
Ming Z
MZ
D000818:Animals; D000833:Animals, Suckling; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001798:Blood Proteins / Q000378:metabolism; D001806:Blood Urea Nitrogen; D048271:Chitosan / Q000008:administration & dosage*; D002784:Cholesterol / Q000097:blood; D019587:Dietary Supplements; D013006:Growth Hormone / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis* / Q000235:genetics; D008034:Lincomycin / Q000008:administration & dosage; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008351:Mannans / Q000008:administration & dosage*; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism; D009844:Oligosaccharides / Q000008:administration & dosage*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011897:Random Allocation; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000662:veterinary; D013552:Swine / Q000097:blood / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood
D000900:Anti-Bacterial Agents; D001798:Blood Proteins; D008351:Mannans; D009844:Oligosaccharides; D012333:RNA, Messenger; D014280:Triglycerides; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D048271:Chitosan; D002784:Cholesterol; D008034:Lincomycin