Correlation of heart rate turbulence with sympathovagal balance in patients with acute myocardial infarction.
To examine the relationship among heart rate turbulence parameters, arterial baroreflex sensitivity, and cardiac sympathetic nerve activity, 15 patients with acute myocardial infarction, presenting with sinus rhythm and > or = 3 ventricular premature beats/24 hr were studied at least 2 weeks after acute myocardial infarction. Turbulence onset (TO) and turbulence slope (TS) were averaged from 3 respective ventricular premature beats. Early heart-to-mediastinum ratio (H/M), delayed H/M, and washout rate were calculated from iodine-123-metaiodobenzylguanidine (123I MIBG) scintigraphy. Arterial baroreflex sensitivity was calculated by phenyrephrine method. Arterial baroreflex sensitivity correlated significantly with TO (r = - 0.75, p < .01) and TS (r = 0.53, p < .05). TO had no correlations with early H/M, delayed H/M, and washout rate. There were no significant correlations between TS and early H/M. However, TS had significant correlation with delayed H/M (r = 0.74, p < .01) and washout rate (r = -0.71, p < .01). Thus, heart rate turbulence of TO and TS parameters depend on sympathovagal balance.
Iwasaki
Masayoshi
M
The Second Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Yuasa
Fumio
F
Yuyama
Reisuke
R
Mimura
Jun
J
Kawamura
Akihiro
A
Motohiro
Masayuki
M
Yo
Masue
M
Sugiura
Tetsuro
T
Iwasaka
Toshiji
T
D019797:3-Iodobenzylguanidine / Q000008:administration & dosage; D001158:Arteries / Q000187:drug effects / Q000503:physiopathology; D017704:Baroreflex / Q000187:drug effects / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D015637:Gated Blood-Pool Imaging; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000503:physiopathology*; D010656:Phenylephrine / Q000008:administration & dosage; D011237:Predictive Value of Tests; D011379:Prognosis; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D014630:Vagus Nerve / Q000187:drug effects / Q000503:physiopathology*
D019275:Radiopharmaceuticals; D010656:Phenylephrine; D019797:3-Iodobenzylguanidine