[Survey of gestational trophoblastic disease incidence among 3.6 million pregnancies in China].
OBJECTIVE
To survey incidence of gestational trophoblastic disease (GTD) in China and to provide useful information for prevention and better treatment of the disease.


METHODS
The survey was retrospectively carried out from 1991 to 2000 and included 143 hospitals in the following seven Chinese provinces: Zhejiang, Jiangsu, Fujian, Anhui, Jiangxi, Shanxi and Henan.


RESULTS
Excluding incomplete data, data from 118 hospitals from seven provinces were finally analyzed. The total numbers of pregnancy and GTD were 3,674, 654 and 14,222, respectively. The GTD cases occurred mainly among 20 - 34 year old women, which accounted for 85.5% of total GTD. The incidence of GTD was 3.87 per thousand. There were 9,194 cases (64.6%) of hydatidiform, 3,452 cases (24.3%) of invasive mole, 1521 cases (10.7%) of choriocarcinoma, 55 cases (0.4%) of placenta-site trophoblastic tumor, respectively.


CONCLUSIONS
The results of this survey are reliable and representative due to large sampling and hospital-based data collection. The incidences of GTD decreased significantly compared with 1950s'. It is important to take pathological examination for GTD and to diagnose complate mole and partial mole correctly.
Shi
Yi-fu
YF
Department of Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
Li
Juan-qing
JQ
Zheng
Wei
W
Chen
Xue-jun
XJ
Qiao
Yu-huan
YH
Hao
Min
M
Zhou
Chong-wan
CW
Hu
Ya-li
YL
Wan
Gui-mei
GM
Sha
Yu-cheng
YC
Zheng
Xiu
X
D000328:Adult; D002681:China / Q000453:epidemiology; D002822:Choriocarcinoma / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D031901:Gestational Trophoblastic Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D006801:Humans; D006828:Hydatidiform Mole / Q000175:diagnosis / Q000453:epidemiology; D015994:Incidence; D011247:Pregnancy; D012189:Retrospective Studies; D018245:Trophoblastic Tumor, Placental Site / Q000175:diagnosis / Q000453:epidemiology; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000453:epidemiology*