title: Synthesis with improved yield and study on the analgesic effect of 2-hydroxyphencyclidine.
abstract: Phencyclidine (1-(1-phenylcyclohexyl)piperidine, CAS 956-90-1, PCP) has shown analgesic effects. Some of its derivatives have been synthesized and their biological properties were studied. Since a hydroxyl group has been added to the position 2 of the cyclohexane ring of PCP, this compound would be more hydrophilic than PCP. This compound was synthesized using a different and improved method with a higher yield. Its analgesic effect was studied using the tail-flick test on rats and was compared with that of ketamine (CAS 1867-66-9). The results showed that 2-hydroxyphencyclidine can increase tail-flick latencies as compared to the control group and indicate that the maximum analgesic effect of this compound occurs 2-5 min after its injection while the effect of ketamine is observed 10-25 min after injection.
authors.affiliation: Department of Science, School of Chemistry, Islamic Azad University, Karaj, Iran. abbas_ahmady_3957@yahoo.com
authors.forename: Abbas
authors.initials: A
authors.lastname: Ahmadi
authors.forename: Mahshid
authors.initials: M
authors.lastname: Shafiezadeh
authors.forename: Yaghoob
authors.initials: Y
authors.lastname: Fathollahi
authors.forename: Mohammad Raouf
authors.initials: MR
authors.lastname: Darvich
authors.forename: Ali
authors.initials: A
authors.lastname: Mahmoudi
authors.forename: Manouchehr
authors.initials: M
authors.lastname: Bahmani
authors.forename: Batol
authors.initials: B
authors.lastname: Rahmati
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D004594:Electrophysiology; D007274:Injections, Intraperitoneal; D007649:Ketamine / Q000494:pharmacology; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D010622:Phencyclidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects
chemical_list: C500208:2-hydroxyphencyclidine; D000700:Analgesics; D016194:Receptors, N-Methyl-D-Aspartate; D007649:Ketamine; D010622:Phencyclidine