Global gene expression responses to cadmium toxicity in Escherichia coli.
Genome-wide analysis of temporal gene expression profiles in Escherichia coli following exposure to cadmium revealed a shift to anaerobic metabolism and induction of several stress response systems. Disruption in the transcription of genes encoding ribosomal proteins and zinc-binding proteins may partially explain the molecular mechanisms of cadmium toxicity.
Wang
Anyou
A
Department of Environmental Sciences, University of Caliifornia, Riverside, CA 92521, USA.
Crowley
David E
DE
D000222:Adaptation, Physiological; D001692:Biological Transport; D002104:Cadmium / Q000494:pharmacology*; D002352:Carrier Proteins / Q000235:genetics; D003090:Coliphages; D004251:DNA Transposable Elements; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D029968:Escherichia coli Proteins / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D020411:Oligonucleotide Array Sequence Analysis; D010957:Plasmids; D011499:Protein Processing, Post-Translational; D012269:Ribosomal Proteins / Q000235:genetics
D002352:Carrier Proteins; D004251:DNA Transposable Elements; D029968:Escherichia coli Proteins; D012269:Ribosomal Proteins; C017800:zinc-binding protein; D002104:Cadmium