Modulation of parvalbumin expression in the motor cortex of parkinsonian rats.
Dopamine deficiency in Parkinson's disease leads to numerous molecular changes in basal ganglia. However, the consequences of these changes on the motor cortex remain unclear. Here we show that the immunoreactivity of parvalbumin, which is expressed in GABAergic interneurons, increases in the primary motor cortex of parkinsonian rats. This increase can be reversed by a subsequent lesion of the subthalamic nucleus. These results suggest that dopamine deficiency induces reversible changes in GABAergic cortical cells, which might be linked with parkinsonian symptoms.
Capper-Loup
Christine
C
Laboratory of Neuromorphology, Department of Neurology, Inselspital, University Hospital, 3010 Bern, Switzerland.
Burgunder
Jean-Marc
JM
Kaelin-Lang
Alain
A
D000818:Animals; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology; D009044:Motor Cortex / Q000737:chemistry / Q000378:metabolism*; D020734:Parkinsonian Disorders / Q000378:metabolism*; D010320:Parvalbumins / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley
D010320:Parvalbumins