(+/-)3,4-methylenedioxymethamphetamine, d-amphetamine, and cocaine impair delayed matching-to-sample performance by an increase in susceptibility to proactive interference.
This study compared the effects of (+/-)3,4-methylenedioxymethamphetamine, d-amphetamine, and cocaine on performance of rats in a delayed matching-to-sample procedure using a variety of indices of performance to determine the mechanism by which working memory task impairments arise. All 3 drugs produced an overall delay-independent decrease in accuracy rather than a delay-dependent increase in the rate of forgetting. This impairment arose as a result of current-trial choice responses being progressively more affected by responses made in the immediately preceding trial as drug dose increased. Therefore, all 3 drugs produced qualitatively similar disruptions in memory task performance best characterized as an impairment arising from proactive sources of interference.
Harper
David N
DN
School of Psychology, Victoria University of Wellington, Wellington, New Zealand. david.harper@vuw.ac.nz
Wisnewski
Regan
R
Hunt
Maree
M
Schenk
Susan
S
D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004193:Discrimination Learning / Q000187:drug effects*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D006213:Hallucinogens / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D013647:Task Performance and Analysis
D018765:Dopamine Uptake Inhibitors; D006213:Hallucinogens; D003042:Cocaine; D018817:N-Methyl-3,4-methylenedioxyamphetamine; D003913:Dextroamphetamine