Polycyclic compounds from aminopolyols and alpha-dicarbonyls: structure and application in the synthesis of exoditopic ligands.
The structure and stereochemistry of the crystalline 2 : 2 condensation product ("glytham") of glyoxal and tris(hydroxymethyl)aminomethane was conclusively determined by X-ray diffractometric analysis. The singular disposition of the heteroatoms suggests the employment of glytham as starting material for the synthesis of ditopic ligands for metal ions. Some derivatives of glytham were prepared and their binding properties towards alkaline metal ions were preliminarily investigated by ESI-MS and NMR.
Giovenzana
Giovanni B
GB
Dipartimento di Scienze Chimiche Alimentari Farmaceutiche Farmacologiche, Novara, Italy. giovenza@pharm.unipmn.it
Palmisano
Giovanni
G
Del Grosso
Erika
E
Giovannelli
Lorella
L
Penoni
Andrea
A
Pilati
Tullio
T