title: Human papillomavirus prevalence at the USA-Mexico border among women 40 years of age and older.
abstract: The incidence of cervical cancer increases with age among USA Hispanics and women living in Latin America starting in the fourth decade of life. We conducted a study of women > or = 40 living at the USA-Mexico border to determine the prevalence and risk factors for human papillomavirus (HPV) infection detected by polymerase chain reaction. In all, 9.2% of participants tested HPV positive. Compared with women aged 50-59, odds ratios of 8.82 and 6.67 were observed for women > or = 60 and 40-49, respectively. Among women aged 40-49, both oncogenic and non-oncogenic HPV infections were detected; however, women > or = 60 were positive for predominantly oncogenic genotypes. HPV risk significantly increased with > or = 2 lifetime sexual partners in adjusted models. These data suggest that the prevalence of HPV infection may have a second peak among post-menopausal Hispanic women.
authors.affiliation: The Moffitt Cancer Center and Research Institute, Tampa, Florida, USA. agiuliano@azcc.arizona.edu
authors.forename: A R
authors.initials: AR
authors.lastname: Giuliano
authors.forename: M R
authors.initials: MR
authors.lastname: Papenfuss
authors.forename: C A
authors.initials: CA
authors.lastname: Denman
authors.forename: J Guernsey
authors.initials: JG
authors.lastname: de Zapien
authors.forename: M
authors.initials: M
authors.lastname: Abrahamsen
authors.forename: J B
authors.initials: JB
authors.lastname: Hunter
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000821:virology; D014626:Vaginal Smears
chemical_list: D004279:DNA, Viral