title: Serum xylosyltransferase I activity, the new biochemical fibrosis marker, is not affected by renal insufficiency.
abstract: OBJECTIVE
  Serum xylosyltransferase I (XT-I) is a marker for the determination of tissue remodeling in systemic sclerosis. Here, we investigated whether renal insufficiency affects XT-I levels in blood.
  
  
  METHODS
  We measured serum XT-I activity in 236 patients with different serum creatinine levels.
  
  
  RESULTS
  XT-I activities in cohorts with increased creatinine levels were not significantly altered compared to controls.
  
  
  CONCLUSIONS
  Serum XT-I activity is applicable as a fibrosis marker independent from renal function.
authors.affiliation: Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Georgstrasse 11, 32545 Bad Oeynhausen, Germany.
authors.forename: Manuela
authors.initials: M
authors.lastname: Schöttler
authors.forename: Sandra
authors.initials: S
authors.lastname: Müller
authors.forename: Sylvia
authors.initials: S
authors.lastname: Schön
authors.forename: Christian
authors.initials: C
authors.lastname: Prante
authors.forename: Joachim
authors.initials: J
authors.lastname: Kuhn
authors.forename: Knut
authors.initials: K
authors.lastname: Kleesiek
authors.forename: Christian
authors.initials: C
authors.lastname: Götting
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000150:complications; D008297:Male; D008875:Middle Aged; D010430:Pentosyltransferases / Q000097:blood*; D051437:Renal Insufficiency / Q000097:blood* / Q000150:complications; D000097608:UDP Xylose-Protein Xylosyltransferase
chemical_list: D015415:Biomarkers; D003404:Creatinine; D010430:Pentosyltransferases; D000097608:UDP Xylose-Protein Xylosyltransferase