Antiproliferative effect of Angelica archangelica fruits.
The aim of this work was to study the antiproliferative effect of a tincture from fruits of Angelica archangelica and the active components using the human pancreas cancer cell line PANC-1 as a model. Significant dose-dependent antiproliferative activity was observed in the tincture with an EC50 value of 28.6 microg/ml. Strong antiproliferative activity resulted from the two most abundant furanocoumarins in the tincture, imperatorin and xanthotoxin. The contribution of terpenes to this activity was insignificant. Imperatorin and xanthotoxin proved to be highly antiproliferative, with EC50 values of 2.7 microg/ml and 3.7 microg/ml, respectively, equivalent to 10 and 17 microM. The results indicate that furanocoumarins account for most of the antiproliferative activity of the tincture.
Sigurdsson
Steinthor
S
Science Institute, University of Iceland, Vatnsmyrarvegur 16, IS-101 Reykjavik, Iceland. sts@raunvis.hi.is
Ogmundsdottir
Helga M
HM
Gudbjarnason
Sigmundur
S
D029970:Angelica archangelica / Q000737:chemistry*; D002455:Cell Division / Q000187:drug effects*; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D005638:Fruit / Q000737:chemistry*; D011564:Furocoumarins / Q000302:isolation & purification* / Q000633:toxicity; D006801:Humans; D008730:Methoxsalen / Q000302:isolation & purification / Q000633:toxicity; D010190:Pancreatic Neoplasms; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity*
D011564:Furocoumarins; D010936:Plant Extracts; C031534:imperatorin; D008730:Methoxsalen