Electrochemical reduction of cytochrome P450 as an approach to the construction of biosensors and bioreactors.
In the present review an attempt was made to present an up-to-date amount of the data on electrochemical reduction of the hemoprotein cytochrome P450. The concept and potentialities of enzyme electrodes--transducers--as the main element for construction of electrochemical biosensors were discussed. Different types of electrodes for bioelectrochemistry were analysed. New nanotechnological approaches to cytochrome P450 immobilisation were reported. It was shown that nanobiotechnology in electrochemistry has potential application in manufacturing biosensors and bioreactors for clinical medicine and pharmacology.
Shumyantseva
Victoria V
VV
Laboratory of Microsomal Oxidation, Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Pogodinskaya Str., 10, Moscow 119121, Russia. viktoria.shumyantseva@ibmc.msk.ru
Bulko
Tatiana V
TV
Archakov
Alexander I
AI
D019149:Bioreactors; D015374:Biosensing Techniques / Q000295:instrumentation*; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry*; D004563:Electrochemistry; D004566:Electrodes; D010084:Oxidation-Reduction; D012996:Solutions / Q000737:chemistry
D012996:Solutions; D003577:Cytochrome P-450 Enzyme System