title: NF-kappaB as a molecular target in adjuvant therapy of gastrointestinal carcinomas.
abstract: OBJECTIVE
  To describe the role of nuclear factor-kappa B (NF-kappaB) in cancer treatment.
  
  
  METHODS
  We searched the Pubmed database (until Oct, 2004) with the keywords of gastrointestinal carcinoma, NF-kappaB, inhibitor, cancer treatment molecular target and chemoresistance. We reviewed the literature in the role of NF-kappaB activation in chemoresistance, tumour growth suppression and enhancement of apoptosis in gastrointestinal carcinomas.
  
  
  CONCLUSIONS
  Several possible strategies for inhibiting NF-kappaB activation are identified. The importance of targeting NF-kappaB as a potential therapeutic approach in clinical medicine was discussed.
authors.affiliation: Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China. yingyan3y@yahoo.com.cn
authors.forename: Y Y
authors.initials: YY
authors.lastname: Yu
authors.forename: Q
authors.initials: Q
authors.lastname: Li
authors.forename: Z G
authors.initials: ZG
authors.lastname: Zhu
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D017024:Chemotherapy, Adjuvant; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy* / Q000378:metabolism*; D006801:Humans; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000502:physiology*
chemical_list: D000970:Antineoplastic Agents; D016328:NF-kappa B