title: [The neuronal level of motor activity: determination of motor cortex excitability by TMS].
abstract: Transcranial magnetic stimulation as mapping method offers the possibility to measure aspects of motor cortex excitability painlessly and non-invasively. Using this neurophysiological tool, new insights into the effects of central-acting drugs are possible. Particularly striking seems to be the potential of this approach to gain new insights into neurobiological processes associated with neuropsychiatric diseases like schizophrenia or major depression. In combination with genetic aspects, TMS is able to bridge the gap between molecular research and clinical approach.
authors.affiliation: Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universität Regensburg. peter.eichhammer@medbo.de
authors.forename: Peter
authors.initials: P
authors.lastname: Eichhammer
authors.forename: Berthold
authors.initials: B
authors.lastname: Langguth
authors.forename: Jürgen
authors.initials: J
authors.lastname: Müller
authors.forename: Göran
authors.initials: G
authors.lastname: Hajak
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001931:Brain Mapping; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000503:physiopathology; D004292:Dominance, Cerebral / Q000502:physiology; D004409:Dyskinesia, Drug-Induced / Q000175:diagnosis / Q000503:physiopathology*; D019054:Evoked Potentials, Motor / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008280:Magnetics; D009044:Motor Cortex / Q000187:drug effects* / Q000503:physiopathology; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D011596:Psychomotor Disorders / Q000175:diagnosis / Q000503:physiopathology*; D018080:Receptors, GABA-B / Q000502:physiology; D012016:Reference Values; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology; D012815:Signal Processing, Computer-Assisted
chemical_list: D014150:Antipsychotic Agents; D018080:Receptors, GABA-B