Celiac disease-related antibodies in an epilepsy cohort and matched reference population.
Celiac disease (CD) is a common immunologically mediated enteropathic condition manifesting in genetically predisposed individuals after exposure to wheat gluten. CD may be associated with a number of neurological disorders, and the prevalence of epilepsy is reported to be increased in patients with CD. We studied the prevalence of CD-associated antibodies in a cohort of 968 patients with epilepsy and in a population-based reference group of 584 subjects. There was no difference in the prevalence of IgA and IgG class antigliadin antibodies (AGAbA and AGAbG, respectively), endomysial antibodies (EMA), and tissue transglutaminase antibodies (tTGAbA) between patients with epilepsy and the control population. This suggests the presence of CD to be the same in patients with epilepsy and the reference population. However, AGAbA was more prevalent in patients with primary generalized epilepsy (19.6%) than in the reference population (10.6%, relative risk 1.8, 95% confidence interval 1.1-3.0, P=0.012).
Ranua
Jouni
J
Department of Neurology, Seinäjoki Central Hospital, Seinä-joki, Finland. jouni.ranua@netikka.fi
Luoma
Katja
K
Auvinen
Anssi
A
Mäki
Markku
M
Haapala
Anna-Maija
AM
Peltola
Jukka
J
Raitanen
Jani
J
Isojärvi
Jouko
J
D000906:Antibodies / Q000145:classification / Q000378:metabolism*; D001323:Autoantibodies / Q000276:immunology; D016022:Case-Control Studies; D002446:Celiac Disease / Q000453:epidemiology / Q000276:immunology*; D015331:Cohort Studies; D016001:Confidence Intervals; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D004827:Epilepsy / Q000453:epidemiology / Q000276:immunology*; D005903:Gliadin / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D018485:Muscle Fibers, Skeletal / Q000276:immunology; D016017:Odds Ratio; D011159:Population Surveillance; D015995:Prevalence; D011503:Transglutaminases / Q000276:immunology
D000906:Antibodies; D001323:Autoantibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D005903:Gliadin; D011503:Transglutaminases