Association between sex, nutritional status, severity of dengue hemorrhagic fever, and immune status in infants with dengue hemorrhagic fever.
The association between sex, nutritional status, and the severity of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), and immune status was investigated in 245 Vietnamese infants with predominantly primary infections with dengue virus. Male and female infants were at equal risk of developing DHF/DSS. However, infants of low height and weight for age were under-represented among DHF/DSS cases compared with 533 healthy baby clinic infant controls. Acute illness phase blood levels of selected cytokines (interferon-gamma and tumor necrosis factor-alpha) and serum levels of antibodies to dengue virus were elevated in the same range in male and female infants with DHF/DSS, as well as in infants with and without malnutrition.
Nguyen
Thanh Hung
TH
Department of Dengue Hemorrhagic Fever, Children's Hospital No. 1, Ho Chi Minh City, Vietnam. hungdhf@hcm.fpt.vn <hungdhf@hcm.fpt.vn>
Nguyen
Trong Lan
TL
Lei
Huan-Yao
HY
Lin
Yee-Shin
YS
Le
Bich Lien
BL
Huang
Kao-Jean
KJ
Lin
Chiou-Feng
CF
Do
Quang Ha
QH
Vu
Thi Que Huong
TQ
Lam
Thi My
TM
Yeh
Trai-Ming
TM
Huang
Jyh-Hsiung
JH
Liu
Ching-Chuan
CC
Halstead
Scott B
SB
D003715:Dengue / Q000276:immunology / Q000503:physiopathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009752:Nutritional Status; D012737:Sex Factors