title: Effect of subthalamic nucleus stimulation patterns on motor performance in Parkinson's disease.
abstract: We studied different patterns of deep brain stimulation (DBS), but same average rate, in seven Parkinson disease patients performing a wrist flexion/extension task. Movement times were shorter with regular (continuous) stimulation than cycled 'on' and 'off' for 0.1s (mean difference 0.129 s; 95% confidence interval [CI], 0.228-0.029 s; P < 0.007) and tended to be shorter than cycling at 0.5s (mean difference 0.076 s, 95% CI, 0.171 to -0.020 s; P < 0.6). Movement times under stimulation cycling at 0.5 s tended to be shorter than cycling at 0.1 s (mean difference, 0.083 s, 95% CI, 0.188 to -0.022 s, P < 0.12). Any therapeutic mechanisms of action of DBS must account for patterns of stimulation.
authors.affiliation: Department of Neurology, National Primate Research Center, University of Wisconsin-Madison, H6/538 CSC, 600 Highland Ave., Madison, WI 53792, USA. montgomery@neurology.wisc.edu
authors.forename: Erwin B
authors.initials: EB
authors.lastname: Montgomery
mesh_terms: D000328:Adult; D000368:Aged; D046690:Deep Brain Stimulation / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D009046:Motor Neurons / Q000502:physiology; D009068:Movement / Q000502:physiology; D010300:Parkinson Disease / Q000503:physiopathology* / Q000628:therapy*; D013269:Stochastic Processes; D020531:Subthalamic Nucleus / Q000502:physiology*; D014955:Wrist Joint / Q000502:physiology