Therapeutic efficacy of different antidotal mixtures against poisoning with GF-agent in mice.
The toxicity of cyclohexyl methylphosphonofluoridate (GF-agent; cyclosarin) and therapeutic efficacy of four oximes (trimedoxime, methoxime, obidoxime and HI-6) in combination with atropine or benactyzine (BNZ) was studied in mice. The oxime therapy combined with anticholinergic drug was administered intramusculary (i.m.) 1 or 2 min after i.m. GF-agent challenge. All the drugs were applied in dose of 20% of LD50. Obidoxime and trimedoxime that were combined with atropine were less effective than methoxime and HI-6 in combination with BNZ when applied 2 minutes after GF-agent poisoning. When the drugs were administered 1 min after GF-agent challenge already, in case of methoxime, the faster application of therapy resulted in significantly higher protective ratio, while for obidoxime the therapeutic effectivity did not depend significantly on the seasonableness of therapeutic intervention. The present findings show that all four combinations of oxime with anticholinergic drug decrease the GF-agent toxicity more than twofold regardless of the time of treatment administration.
Bartosová
Lucie
L
Department of Toxicology, Purkynĕ Military Medical Academy, Hradec Králové, Czech Republic. sevelova@pmfhk.cz
Kunesová
Gabriela
G
Kuca
Kamil
K
Vachek
Josef
J
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D001285:Atropine / Q000627:therapeutic use; D001535:Benactyzine / Q000627:therapeutic use; D002619:Chemical Warfare Agents / Q000506:poisoning*; D005260:Female; D051379:Mice; D062025:Organophosphate Poisoning; D009943:Organophosphorus Compounds; D010091:Oximes / Q000627:therapeutic use
D000931:Antidotes; D002619:Chemical Warfare Agents; D009943:Organophosphorus Compounds; D010091:Oximes; D001535:Benactyzine; D001285:Atropine; C053914:cyclohexyl methylphosphonofluoridate