Statins and autoimmune diseases.
Inhibitors of 3-hydroxy-3methylglytaryl coenzyme A (HMG-CoA) reductase or statins are effective lipid lowering drugs widely used in cardiovascular disease. In the recent years, pleotropic effects of statins have been reported, which include anti-inflammatory and immunomodulatory properties. This review discusses the anti-inflammatory and immunomodulatory roles of statins and their possible use for the treatment of other inflammatory diseases or conditions with the involvement of the immune system.
Gurevich
Victor S
VS
Mechnicov's State Medical Academy, The Center of Atherosclerosis and Lipid Disorders, Tel-Hashomer, Israel.
Shovman
Ora
O
Slutzky
Liat
L
Meroni
Pier Luigi
PL
Shoenfeld
Yehuda
Y
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors