title: Evaluation of cytologic screening results of the cervix.
abstract: The aim of this study was to evaluate retrospectively cytologic screening for cancers and precancerous lesions of the cervix and to research whether biopsy is overused among women with a cytologic diagnosis of atypical squamous cells of undetermined significance (ASCUS). We examined 28 469 smears obtained over 5 years. The patients were referred when the result of the smear was abnormal for a colposcopic biopsy, endocervical curettage, or a repeat Papanicolaou smear. The results of the screening of 28 469 smears are as follows: 699 (2.45%) ASCUS, 67 (0.23%) low-grade squamous intraepithelial lesions (LGSIL), 43 (0.15%) high-grade squamous intraepithelial lesions (HGSIL), 1 epidermoid carcinoma, 31 (0.10%) atypical glandular cells, and 1 adenocarcinoma. Histologic examination of the cervix was done in 119 patients (17.0%) of ASCUS, 13 patients (10.9%) of LGSIL, and 15 patients (12.6%) of HGSIL and cervical carcinoma. In the 119 women with histological examination, histologic examination was generally performed in patients with ASCUS neoplastic Papanicolaou smear, and histologic diagnosis of low-grade, high-grade, or invasive lesion of the cervix was made in 23.5% of women with ASCUS; in these patients, 46.4% were cytologic LGSIL and 53.5 % were cytologic HGSIL and cervical carcinoma. In the aspect of these findings, we concluded that for patients with a cytologic diagnosis of ASCUS, more aggressive interventions should be performed.
authors.affiliation: Department of Obstetrics and Gynecology, Zeynep Kamil Women and Children Education and Research Hospital, Istanbul, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Yalti
authors.forename: B
authors.initials: B
authors.lastname: Gürbüz
authors.forename: R
authors.initials: R
authors.lastname: Bilgiç
authors.forename: Y
authors.initials: Y
authors.lastname: Cakar
authors.forename: S
authors.initials: S
authors.lastname: Eren
mesh_terms: D001706:Biopsy; D002277:Carcinoma / Q000175:diagnosis* / Q000473:pathology*; D003127:Colposcopy; D005260:Female; D006801:Humans; D008403:Mass Screening; D065006:Papanicolaou Test; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000473:pathology*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000473:pathology*