Function of the protein RPE65 in the visual cycle.
A protein called RPE65 performs a key role in the trans-cis isomerization of retinol in the retinal pigment epithelium of the eye. The palmitoylation of RPE65 serves to switch off the visual cycle in darkness and to switch it on in the light.
Wolf
George
G
Department of Nutritional Sciences and Toxicology, University of California, Berkeley, USA.
D000818:Animals; D002352:Carrier Proteins; D005136:Eye Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D010857:Pigment Epithelium of Eye / Q000378:metabolism / Q000502:physiology*; D012160:Retina / Q000378:metabolism / Q000502:physiology*; D014785:Vision, Ocular / Q000502:physiology*; D019745:cis-trans-Isomerases; D000099178:Retinoid Isomerohydrolase
D002352:Carrier Proteins; D005136:Eye Proteins; D019745:cis-trans-Isomerases; D000099178:Retinoid Isomerohydrolase