title: Familial Mediterranean fever--a not so unusual cause of abdominal pain.
abstract: Familial Mediterranean fever is a hereditary syndrome characterised by recurrent episodes of fever and serositis, resulting in pain in the abdomen, chest, joints and muscles. It is primarily diagnosed in people of Jewish, Arabic, Turkish or Armenian ancestry and is caused by mutations in the gene encoding for pyrin. Abdominal FMF attacks resemble the clinical presentation of 'acute abdomen', with severe abdominal pain and rigidity, but in FMF symptoms always resolve spontaneously. It is important to distinguish these regular pain episodes from small bowel obstruction due to adhesions to prevent life-threatening bowel strangulation. In most cases, colchicine will prevent new painful attacks. This seminar also discusses other causes of abdominal pain in FMF patients.
authors.affiliation: Department of Medicine, Division of General Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. a.simon@aig.umcn.nl
authors.forename: Anna
authors.initials: A
authors.lastname: Simon
authors.forename: Jos W M
authors.initials: JW
authors.lastname: van der Meer
authors.forename: Joost P H
authors.initials: JP
authors.lastname: Drenth
mesh_terms: D015746:Abdominal Pain / Q000209:etiology*; D000328:Adult; D000686:Amyloidosis / Q000209:etiology / Q000517:prevention & control; D003078:Colchicine / Q000627:therapeutic use; D003937:Diagnosis, Differential; D010505:Familial Mediterranean Fever / Q000150:complications / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D006074:Gout Suppressants / Q000627:therapeutic use; D006801:Humans; D008297:Male
chemical_list: D006074:Gout Suppressants; D003078:Colchicine