title: Brain MRI findings in cirrhotic patients: correlation with Doppler US hepatic flow parameters.
abstract: OBJECTIVE
  To determine the relationship of basal ganglia alterations demonstrated on brain MRI and clinical presentation, evaluated with Child-Pugh score, using Color Doppler Ultrasonography parameters of portal hemodynamics in cirrhotic patients with signs of portal hypertension.
  
  
  METHODS
  Twenty randomly selected cirrhotic patients (16 males and 4 females with a mean age of 63.6+/-8.9 years) classified according to Child-Pugh score (grade A=16 patients, grade B=4), were submitted to Color Doppler US evaluation of hepatic flow and brain MRI. The obtained flow parameters were: PVD, PVCSA, MPVF, MPVFV, HAD, MHAF, hepatic artery RI, CI and MHI. The basal ganglia signal intensity, on T1-weighted images on brain MRI was evaluated both qualitatively (normal, mild, moderate and severe) and quantitatively with the ROI method.
  
  
  RESULTS
  Among Color Doppler parameters, only the CI exhibited a modest correlation with the Child's clinical score (p for linear trend by ANOVA <0.05). Subjective MRI grading demonstrated an excellent correlation with the qualitative assessment of signal density (Spearman p=0.95, p<0.01). When signal intensity on T1-weighted images was analyzed as a continuous variable with normal distribution and ultrasonographic parameters as possible determinants, the portal vein diameter (PVD) and consequently the cross-sectional area (PVCSA) emerged as the sole predictor of MR signal intensity (Pearson's r=0.58, p=0.01).
  
  
  CONCLUSIONS
  Although this is a preliminary study and further research should be performed including a larger number of patients, it suggests that Color Doppler US might play a prognostic role in predicting hepatocellular dysfunction and hepatic encephalopathy.
authors.affiliation: Department of Radiology, University Hospital of Patras, Rio, Greece. Solomou@med.upatras.gr
authors.forename: Ek
authors.initials: E
authors.lastname: Solomou
authors.forename: G
authors.initials: G
authors.lastname: Terzis
authors.forename: I
authors.initials: I
authors.lastname: Tsota
authors.forename: An
authors.initials: A
authors.lastname: Kalogeropoulos
authors.forename: D
authors.initials: D
authors.lastname: Velissaris
authors.forename: M
authors.initials: M
authors.lastname: Kiriakopoulou
authors.forename: Ch
authors.initials: Ch
authors.lastname: Karatza
mesh_terms: D000368:Aged; D001479:Basal Ganglia / Q000473:pathology; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D008102:Liver Circulation; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D018615:Ultrasonography, Doppler, Color