[Coinfection with HIV and HCV--epidemiologic, diagnostic, clinical and therapeutic implications].
Because of shared transmission pathways, coinfection with HIV and HCV is common. Besides evidence is accumulating that HIV infection may be a cofactor for heterosexual and perinatal transmission of HCV infection. The increasing survival of patients on HAART has emphasized the importance of treating liver disease because co-infected patients are now often dying of their liver disease. There is a common opinion that HIV infection causes rapid and more severe course of HCV-related liver disease. The impact of HCV infection on HIV disease progression is controversial. The treatment of patients co-infected with HIV and HCV is difficult. Therapeutic options depend on immunological status of patients and severity of liver disease. In addition hepatotoxicity and drug interactions should be considered.
Jabłonowska
Elzbieta
E
Katedra i Klinika Chorób Zakaźnych i Hepatologii, Uniwersytet Medyczny w Lodzi.
D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D023241:Antiretroviral Therapy, Highly Active; D000998:Antiviral Agents / Q000008:administration & dosage*; D018450:Disease Progression; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D019698:Hepatitis C, Chronic / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D016898:Interferon-alpha / Q000008:administration & dosage; D012254:Ribavirin / Q000008:administration & dosage; D012307:Risk Factors
D000998:Antiviral Agents; D016898:Interferon-alpha; D012254:Ribavirin