title: Liver phosphatases in mice treated with lead during murine ancylostomiasis.
abstract: Both infective larvae and pollutants disturb the homeostasis of female Swiss albino mice, causing ancylostomiasis and severe immunophysiological changes. In our experimental design, mice in group A were fed 0.01 mg of lead nitrate before infection with 500 larvae of Ancylostoma caninum, mice in group B were infected with larvae without previous lead treatment, and group C received lead nitrate treatment alone. Control animals in group D were neither treated with lead nitrate nor infected with larvae. While all three experimental groups showed disturbances in liver alkaline phosphatase (ALP) and acid phosphatase (ACP), group C receiving lead nitrate treatment alone and group A receiving lead nitrate with infection showed increased levels of ACP and decreased levels of ALP.
authors.affiliation: Department of Zoology, Nagarjuna University, Nagarjuna Nagar (A.P.) 522 510, India.
authors.forename: B D J
authors.initials: BD
authors.lastname: Satyalatha
authors.forename: V V
authors.initials: VV
authors.lastname: Vardhani
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000724:Ancylostomiasis / Q000201:enzymology* / Q000523:psychology; D000818:Animals; D005260:Female; D007814:Larva; D007854:Lead / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D051379:Mice; D010270:Parasite Egg Count; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*
chemical_list: D007854:Lead; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D010744:Phosphoric Monoester Hydrolases