Mast cells enhance T cell activation: Importance of mast cell-derived TNF.
Mast cells are not only important effector cells in immediate hypersensitivity reactions and immune responses to pathogens but also can contribute to T cell-mediated disorders. However, the mechanisms by which mast cells might influence T cells in such settings are not fully understood. We find that mast cells can enhance proliferation and cytokine production in multiple T cell subsets. Mast cell-dependent enhancement of T cell activation can be promoted by FcepsilonRI-dependent mast cell activation, TNF production by both mast cells and T cells, and mast cell-T cell contact. However, at high concentrations of cells, mast cells can promote T cell activation independent of IgE or TNF. Finally, mast cells also can promote T cell activation by means of soluble factors. These findings identify multiple mechanisms by which mast cells can influence T cell proliferation and cytokine production.
Nakae
Susumu
S
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305-5176, USA.
Suto
Hajime
H
Kakurai
Maki
M
Sedgwick
Jonathon D
JD
Tsai
Mindy
M
Galli
Stephen J
SJ
D000818:Animals; D049109:Cell Proliferation; D016207:Cytokines / Q000378:metabolism; D004139:Dinitrofluorobenzene; D008213:Lymphocyte Activation / Q000276:immunology*; D008407:Mast Cells / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D016685:Mitomycin; D017455:Receptors, IgE / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*
D016207:Cytokines; D017455:Receptors, IgE; D014409:Tumor Necrosis Factor-alpha; D016685:Mitomycin; D004139:Dinitrofluorobenzene