[Markers of endothelial dysfunction in attack-like schizophrenia].
The activity of leukocyte elastase (LE) and two markers for vascular endothelial cells (EC) dysfunction/lesion--von Willebrand factor (WF) and C-reactive protein (C-RP)--was determined in the blood plasma of 22 male patients, aged 23.7 +/- 5.5 years with attack-like schizophrenia (ALS) and 24 matched controls. A significant increase of WF, C-RP and LE was found in the patients compared to controls indicating EC dysfunction and/or lesion in ALS schizophrenia. Positive correlations between LE activity and WF concentrations as well as between WF and severity of clinical symptoms in ALS patients imply a vascular layer lesion of the blood-brain barrier.
Shcherbakova
I V
IV
Kaleda
V G
VG
Barkhatova
A N
AN
Kliushnik
T P
TP
D000293:Adolescent; D000328:Adult; D001812:Blood-Brain Barrier; D002097:C-Reactive Protein / Q000032:analysis*; D003627:Data Interpretation, Statistical; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D019272:Leukocyte Elastase / Q000097:blood*; D008297:Male; D012559:Schizophrenia / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D014841:von Willebrand Factor / Q000032:analysis*
D014841:von Willebrand Factor; D002097:C-Reactive Protein; D019272:Leukocyte Elastase