Exercise might favor reverse cholesterol transport and lipoprotein clearance: potential mechanism for its anti-atherosclerotic effects.
Livers of C57 BL/6 mice exercised for 2 weeks showed a dramatic increase in scavenger receptor B1 (SR-B1), CD36 and low density lipoprotein (LDL) receptor and a decrease in acetyl LDL receptor gene expression. These effects on lipoprotein receptors are reminiscent of the effects mediated by peroxisome proliferator-activated receptor (PPARgamma) ligands.
Wei
Chen
C
Department of Cardiology, Emory University, Atlanta, GA 30322, United States.
Penumetcha
Meera
M
Santanam
Nalini
N
Liu
Ya-Guang
YG
Garelnabi
Mahdi
M
Parthasarathy
Sampath
S
D000818:Animals; D001161:Arteriosclerosis / Q000517:prevention & control*; D001692:Biological Transport; D018955:CD36 Antigens / Q000235:genetics; D002784:Cholesterol / Q000378:metabolism*; D008074:Lipoproteins / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D047493:PPAR alpha / Q000502:physiology; D047495:PPAR gamma / Q000502:physiology; D010805:Physical Conditioning, Animal; D011973:Receptors, LDL / Q000235:genetics / Q000502:physiology
D018955:CD36 Antigens; D008074:Lipoproteins; D047493:PPAR alpha; D047495:PPAR gamma; D011973:Receptors, LDL; D002784:Cholesterol