title: Saccade velocity as a surrogate disease marker in spinocerebellar ataxia type 2.
abstract: We measured in 82 spinocerebellar ataxia type 2 (SCA2) patients and in 80 controls maximal saccade velocity (MSV) and correlated it to polyglutamine expansion size and disease duration. MSV is strongly decreased in SCA2 patients and is influenced mostly by polyglutamine size.
authors.affiliation: Clinic for Neurology, University Hospital, Frankfurt, am Main, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Seifried
authors.forename: L
authors.initials: L
authors.lastname: Velázquez-Pérez
authors.forename: N
authors.initials: N
authors.lastname: Santos-Falcón
authors.forename: M
authors.initials: M
authors.lastname: Abele
authors.forename: U
authors.initials: U
authors.lastname: Ziemann
authors.forename: L E
authors.initials: LE
authors.lastname: Almaguer
authors.forename: E
authors.initials: E
authors.lastname: Martínez-Góngora
authors.forename: G
authors.initials: G
authors.lastname: Sánchez-Cruz
authors.forename: N
authors.initials: N
authors.lastname: Canales
authors.forename: R
authors.initials: R
authors.lastname: Pérez-González
authors.forename: M
authors.initials: M
authors.lastname: Velázquez-Manresa
authors.forename: B
authors.initials: B
authors.lastname: Viebahn
authors.forename: S
authors.initials: S
authors.lastname: Stuckrad-Barre
authors.forename: T
authors.initials: T
authors.lastname: Klockgether
authors.forename: M
authors.initials: M
authors.lastname: Fetter
authors.forename: G
authors.initials: G
authors.lastname: Auburger
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D015415:Biomarkers; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015835:Ocular Motility Disorders / Q000503:physiopathology*; D010455:Peptides / Q000032:analysis; D012438:Saccades / Q000502:physiology*; D020754:Spinocerebellar Ataxias / Q000175:diagnosis*; D013997:Time Factors
chemical_list: D015415:Biomarkers; D010455:Peptides; C097188:polyglutamine