Can successful vaccines teach us how to induce efficient protective immune responses?
Some recently introduced vaccines that have excellent efficacy records have been developed without a clear understanding of their mechanism of protection. In fact, successful vaccines have often emerged out of empirical observations and have only rarely been the result of a rational use of the continuously increasing immunological knowledge available to scientists. However, a posteriori deciphering of the biological bases for the efficacy of successful vaccines should be an essential component of research efforts directed at the development of new vaccines for the most challenging infectious diseases.
Lambert
Paul-Henri
PH
Centre of Vaccinology, Department of Immunology-Pathology, University of Geneva-CMU, 1 rue Michel-Servet, 1211 Geneva, Switzerland. paul.lambert@medecine.unige.ch
Liu
Margaret
M
Siegrist
Claire-Anne
CA
D000368:Aged; D000906:Antibodies / Q000097:blood; D000915:Antibody Affinity; D000940:Antigenic Variation; D000941:Antigens / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007156:Immunologic Memory; D007223:Infant; D014612:Vaccines / Q000276:immunology*
D000906:Antibodies; D000941:Antigens; D014612:Vaccines