Retymicin, galtamycin B, saquayamycin Z and ribofuranosyllumichrome, novel secondary metabolites from Micromonospora sp. Tü 6368. I. Taxonomy, fermentation, isolation and biological activities.
A new xanthone compound named retymicin (1) was isolated together with galtamycin B (2) and saquayamycin Z (3), new members of the galtamycin and saquayamycin families, respectively, and the new lumichrome derivative 1-(alpha-ribofuranosyl)-lumichrome (4) from Micromonospora strain Tü 6368, isolated from a soil sample collected in Romania. Retymicin, galtamycin B and saquayamycin Z show cytostatic effects to various human tumor cell lines whereas saquayamycin Z is also active against Gram-positive bacteria.
Antal
Noémi
N
Mikrobiologisches Institut, Universität Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany.
Fiedler
Hans-Peter
HP
Stackebrandt
Erko
E
Beil
Winfried
W
Ströch
Karsten
K
Zeeck
Axel
A
D018943:Anthracyclines / Q000302:isolation & purification* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002240:Carbohydrate Sequence; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006801:Humans; D008826:Microbial Sensitivity Tests; D008847:Micromonospora / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008969:Molecular Sequence Data; D012383:Romania; D012988:Soil Microbiology; D044004:Xanthones / Q000302:isolation & purification* / Q000494:pharmacology; D000095602:Angucyclines and Angucyclinones
D018943:Anthracyclines; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D044004:Xanthones; C500114:retymicin; C500113:saquayamycin Z; D000095602:Angucyclines and Angucyclinones; C049641:galtamycin