Recent advances in the management of gout and hyperuricemia.
OBJECTIVE
To review the recent advances in the management of gout and hyperuricemia.


RESULTS
The first quality indicators for gout management have been proposed. Selective COX II inhibitors, as well as traditional NSAIDs, are effective in acute gout. A new xanthine oxidase inhibitor, febuxostat, and pegylated uricases are in clinical trials.


CONCLUSIONS
The therapeutic aims in gout include termination of the acute attack as promptly and gently as possible, prevention of future attacks, prevention or reversal of complications of the, and prevention or reversal of associated features such as obesity, hypertriglyceridemia, hypertension, or alcoholism.
Wortmann
Robert L
RL
Department of Internal Medicine, University of Oklahoma College of Medicine, Tulsa, Oklahoma 74135, USA. Robert-wortmann@ouhsc.edu
D006073:Gout / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D033461:Hyperuricemia / Q000188:drug therapy* / Q000378:metabolism; D016896:Treatment Outcome; D014527:Uric Acid / Q000378:metabolism; D014528:Uricosuric Agents / Q000627:therapeutic use*
D014528:Uricosuric Agents; D014527:Uric Acid