Changes in plasma lipid and antioxidant activity in rats as a result of naringin and red grapefruit supplementation.
The aim of this investigation was to compare the influence of naringin versus red grapefruit juice on plasma lipid levels and plasma antioxidant activity in rats fed cholesterol-containing and cholesterol-free diets. The antioxidant activity of a correlated quantity of red grapefruit juice was higher than that of naringin. Forty-two male Wistar rats were randomly divided into six groups of 7 named control, naringin, grapefruit, Chol, Chol/naringin, and Chol/grapefruit. The rats of the control group were fed basal diet (BD) and 1-2 mL of distilled water. To the BD of the other five groups were added 0.46-0.92 mg of naringin dissolved in 1-2 mL of distilled water (naringin), 1-2 mL of red grapefruit juice (grapefruit), 1% of nonoxidized cholesterol (NOC) and 1-2 mL of distilled water (Chol), 1% of NOC and 0.46-0.92 mg of naringin in 1-2 mL of water (Chol/naringin), and 1% of NOC and 1-2 mL of red grapefruit juice (Chol/grapefruit). After 30 days of different feeding, it was found that diets supplemented with red grapefruit juice and to a lesser degree with naringin improved the plasma lipid levels mainly in rats fed cholesterol and increased the plasma antioxidant activity. In conclusion, naringin is a powerful plasma lipid lowering and plasma antioxidant activity increasing flavonone. However, fresh red grapefruit is preferable than naringin: it more effectively influences plasma lipid levels and plasma antioxidant activity and, therefore, could be used as a valuable supplement for disease-preventing diets.
Gorinstein
Shela
S
Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University-Hadassah Medical School, Jerusalem, Israel. gorin@cc.huji.ac.il
Leontowicz
Hanna
H
Leontowicz
Maria
M
Krzeminski
Ryszard
R
Gralak
Mikolaj
M
Delgado-Licon
Efren
E
Martinez Ayala
Alma Leticia
AL
Katrich
Elena
E
Trakhtenberg
Simon
S
D000818:Animals; D000975:Antioxidants / Q000032:analysis*; D001628:Beverages; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D032083:Citrus paradisi; D004032:Diet; D019587:Dietary Supplements; D044950:Flavanones / Q000008:administration & dosage*; D005638:Fruit; D008055:Lipids / Q000097:blood*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D002791:Cholesterol, Dietary; D044950:Flavanones; D008055:Lipids; C005274:naringin