title: Analysis of cerebellum proteomics in the hydrocephalic H-Tx rat.
abstract: The H-Tx rat is a polygenic inherited model of hydrocephalus. In order to identify disease-specific biomarkers associated with congenital hydrocephalus, comparative proteomic analysis was used to screen cerebellum proteins in H-Tx rats at 1 day after birth. Seven proteins showed significant changes in hydrocephalic H-Tx rats compared with Sprague-Dawley and normal H-Tx rats, including HMG-1, CDCrel-1A, mitochondrial ATP synthase, ERp29, NADP+-ICDH, CCT beta and gamma. This indicates that the hydro-cephalus in H-Tx rats may be the result of a panel of proteins. In particular, the presence of HMG-1 and lack of CDCrel-1 in hydrocephalic H-Tx rats suggests that the use of two protein markers will provide further insight with respect to congenital hydrocephalus.
authors.affiliation: Department of Neurosurgery, Juntendo University School of Medicine, Tokyo, Japan. lix72@hotmail.com
authors.forename: Xianfeng
authors.initials: X
authors.lastname: Li
authors.forename: Masakazu
authors.initials: M
authors.lastname: Miyajima
authors.forename: Reiko
authors.initials: R
authors.lastname: Mineki
authors.forename: Hikari
authors.initials: H
authors.lastname: Taka
authors.forename: Kimie
authors.initials: K
authors.lastname: Murayama
authors.forename: Hajime
authors.initials: H
authors.lastname: Arai
mesh_terms: D000818:Animals; D015415:Biomarkers; D002531:Cerebellum / Q000737:chemistry* / Q000503:physiopathology; D004195:Disease Models, Animal; D015180:Electrophoresis, Gel, Two-Dimensional; D006849:Hydrocephalus / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology*; D010641:Phenotype; D040901:Proteomics; D051381:Rats; D011922:Rats, Mutant Strains; D017207:Rats, Sprague-Dawley
chemical_list: D015415:Biomarkers