title: Long-term follow-up of lymphocyte populations and cellular cytokine production in patients with chronic graft-versus-host disease treated with extracorporeal photopheresis.
abstract: We studied lymphocyte populations and cytokine-expression profiles of ten patients with chronic graft-versus-host disease who at least transiently responded to photoimmunotherapy. The numbers of lymphocytes, monocytes and dendritic cells rose in most cases. Th1 cells always increased during therapy, supporting the hypothesis that a more favorable immune balance contributes to clinical responses.
authors.forename: Maria Gomes da
authors.initials: MG
authors.lastname: Silva
authors.forename: Lara
authors.initials: L
authors.lastname: Ferreira Neto
authors.forename: António
authors.initials: A
authors.lastname: Guimarães
authors.forename: Alexandra
authors.initials: A
authors.lastname: Machado
authors.forename: António
authors.initials: A
authors.lastname: Parreira
authors.forename: Manuel
authors.initials: M
authors.lastname: Abecasis
mesh_terms: D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D016207:Cytokines / Q000096:biosynthesis*; D005260:Female; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*; D006801:Humans; D016131:Lymphocyte Subsets; D008297:Male; D008875:Middle Aged; D017893:Photopheresis; D018417:Th1 Cells / Q000737:chemistry; D018418:Th2 Cells / Q000737:chemistry
chemical_list: D016207:Cytokines