Association between the 5-HT6 receptor C267T polymorphism and response to antidepressant treatment in major depressive disorder.
The purpose of the present study was to determine if a 5-HT6 receptor polymorphism is associated with antidepressant treatment response in major depressive disorder (MDD). Ninety-one patients with MDD, compared with 127 normal control subjects, were evaluated after an 8-week treatment period. An association analysis revealed no differences in genotype and allele distribution between patients with MDD and normal control subjects. However, there were significant differences in the treatment response in some Hamilton Depression Rating Scale (HAM-D) scores (sleep, activity, somatic anxiety, and total) between genotypes. Moreover, the heterozygote group (CT genotype) had significantly better treatment response than the homozygote group (CC + TT genotypes), especially in the somatic-anxiety subcategory and the total score of HAM-D. These findings imply that a 5-HT6 receptor polymorphism (C267T) is associated with treatment response in MDD.
Lee
Seung-Hwan
SH
Department of Psychiatry, Inje University College of Medicine, Koyang, South Korea.
Lee
Kang-Joon
KJ
Lee
Heon-Jeong
HJ
Ham
Byung-Joo
BJ
Ryu
Seung-Ho
SH
Lee
Min-Soo
MS
D000328:Adult; D000483:Alleles; D000928:Antidepressive Agents / Q000627:therapeutic use*; D004247:DNA / Q000235:genetics; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D005838:Genotype; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D011569:Psychiatric Status Rating Scales; D011985:Receptors, Serotonin / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D000928:Antidepressive Agents; D011985:Receptors, Serotonin; C097216:serotonin 6 receptor; D004247:DNA