title: Leptin and soluble leptin receptor levels in obese children in fasting and satiety states.
abstract: OBJECTIVE
  To investigate the role of soluble leptin receptors in leptin resistance in obese children.
  
  
  METHODS
  Thirty-one obese children (16 boys and 15 girls) with a median age of 12.1 years and 15 age- and sex-matched controls were included in the study. Leptin and soluble leptin receptor levels were measured in fasting and satiety states.
  
  
  RESULTS
  Serum leptin levels were significantly higher and soluble leptin receptor levels were significantly lower in obese children compared to controls in fasting and satiety states. In obese children, there was a high and inverse correlation between leptin levels and soluble leptin receptor levels after fasting. Prepubertal obese children had lower leptin and higher soluble leptin, receptor levels compared to pubertal children in both states.
  
  
  CONCLUSIONS
  In this study, being the first to consider both fasting and satiety states, obese children were found to have higher leptin, but lower soluble leptin receptor levels, compared to controls. With these findings, it can be postulated that leptin resistance in obese children originates from a defect of soluble leptin receptor production.
authors.affiliation: Department of Pediatric Endocrinology, Gazi University, Ankara, Turkey.
authors.forename: Peyami
authors.initials: P
authors.lastname: Cinaz
authors.forename: Aysun
authors.initials: A
authors.lastname: Bideci
authors.forename: M Orhun
authors.initials: MO
authors.lastname: Camurdan
authors.forename: Ayla
authors.initials: A
authors.lastname: Güven
authors.forename: Sevim
authors.initials: S
authors.lastname: Gönen
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D005215:Fasting; D005260:Female; D006801:Humans; D020738:Leptin / Q000032:analysis* / Q000494:pharmacology*; D008297:Male; D009765:Obesity / Q000503:physiopathology*; D011956:Receptors, Cell Surface / Q000032:analysis*; D018121:Receptors, Cytokine; D054411:Receptors, Leptin; D012528:Satiety Response; D012995:Solubility
chemical_list: C515448:LEPR protein, human; D020738:Leptin; D011956:Receptors, Cell Surface; D018121:Receptors, Cytokine; D054411:Receptors, Leptin