Detection of gastrointestinal and abdominal infections by 99mTc-ciprofloxacin.
OBJECTIVE
The aim of the study is detection and evaluation of the abdominal and gastrointestinal infective foci using 99mTc-ciprofloxacin (Laboratory for radioactive isotopes, Vinca).


METHODS
In total 21 patients with clinical suspicion on abdominal or gastrointestinal infection were investigated. In all the patients, planar liver/spleen scintigraphy was performed. Ciprofloxacin chloride (3.5 mg) was mixed with 555 MBq of 99mTc in 3 mL of physiological solution and incubated for 20 min. After slow i.v. injection in a cubital vein, dynamic acquisition (1 f/min) was performed during the first 60 min in the position of interest, followed by static acquisition (500,000 imp) anterior and posterior view, abdomen and pelvis after 1 h and 4 h in all patients. When necessary, additional scintigrams were acquired after 24 h. In all the patients with negative or equivocal findings of planar scintigraphy, emission computerized tomography (SPECT) was performed (60 positions, 6 degrees). Interpretation was made by three independent observers. Additional data were provided using clinical findings, ultrasonography, computed tomography and magnetic resonance imaging, laboratory analyses, and surgical or microbiological confirmation of infection.


RESULTS
There were eleven true-positive findings, seven true negative, two were false negative while one was false positive due to intestinal obstruction. Sensitivity was 79%, specificity 91%, positive predictive value 92%, negative predictive value 77%, accuracy 84%.


CONCLUSIONS
According to our results, scintigraphy with radiolabeled ciprofloxacin is a useful method for detection and assessment of exact localization of abdominal and gastrointestinal infections.
Artiko
V
V
Institute for Nuclear Medicine, Digestive Diseases, ORL, Nephrology and Emergency Unit, CCS, Serbia.
Davidovic
B
B
Nikolic
N
N
Petrovic
M
M
Vlajkovic
M
M
Pesko
P
P
Knezevic
S
S
Dukic
V
V
Stefanovic
B
B
Tulic
C
C
Popovic
N
N
Milosavljevic
T
T
Obradovic
V
V
D000005:Abdomen / Q000000981:diagnostic imaging*; D001424:Bacterial Infections / Q000000981:diagnostic imaging* / Q000378:metabolism; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D005188:False Negative Reactions; D005189:False Positive Reactions; D005767:Gastrointestinal Diseases / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D013154:Spleen / Q000000981:diagnostic imaging / Q000378:metabolism; D014018:Tissue Distribution
D015609:Organotechnetium Compounds; C431804:Technetium Tc 99m ciprofloxacin; D002939:Ciprofloxacin