title: Epithelial splenic cysts.
abstract: BACKGROUND
  Epithelial splenic cysts (ESC) are uncommon lesions of the spleen. The etiopathogenesis of these cysts is controversial, even if Burrig's theory is the most accredited. The histological distinction between epidermoid and mesothelial cysts may be difficult, particularly for monostratified epithelium.
  
  
  METHODS
  In the period between January 1986 and February 2004, 11 patients with ESC were studied. The history, physical findings, all relevant diagnostic studies and treatment were reviewed. All histological material was reviewed in detail with immunohistochemistry for CEA, CA 19-9, cytokeratin and calretinin.
  
  
  RESULTS
  Epidermoid cysts were positive for CEA, CA 19-9, and cytokeratin, but negative for calretinin. Mesothelial cysts were positive for cytokeratin and calretinin, but negative for CEA and CA 19-9.
  
  
  CONCLUSIONS
  Immunohistochemistry allows differential diagnosis between epidermoid and mesothelial cysts. With regard to etiopathogenesis, these data could mean that epidermoid and mesothelial cysts have distinct origins, though at variance with Burrig's theory. Although the ESC in this series were treated by open splenectomy, the recent approach by conservative and laparoscopic techniques offers great promise.
authors.affiliation: Department of Surgery "Pietro Valdoni", University of Rome "La Sapienza", Rome, Italy.
authors.forename: Isabella
authors.initials: I
authors.lastname: Palmieri
authors.forename: Emanuela
authors.initials: E
authors.lastname: Natale
authors.forename: Francesco
authors.initials: F
authors.lastname: Crafa
authors.forename: Antonino
authors.initials: A
authors.lastname: Cavallaro
authors.forename: Pietro Luigi
authors.initials: PL
authors.lastname: Mingazzini
mesh_terms: D000293:Adolescent; D000328:Adult; D018395:CA-19-9 Antigen / Q000096:biosynthesis; D064032:Calbindin 2; D002272:Carcinoembryonic Antigen / Q000096:biosynthesis; D004814:Epidermal Cyst / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000473:pathology; D064030:S100 Calcium Binding Protein G / Q000096:biosynthesis; D013154:Spleen / Q000473:pathology; D013158:Splenic Diseases / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed
chemical_list: D018395:CA-19-9 Antigen; C576764:CALB2 protein, human; D064032:Calbindin 2; D002272:Carcinoembryonic Antigen; D064030:S100 Calcium Binding Protein G; D007633:Keratins