[Multivariate analysis of the parameters related to recurrence of laryngeal papilloma in adult].
OBJECTIVE
To investigate the clinical and pathological characteristics of astrocytoma and the factors related to pathological gradings as well as recurrence in laryngeal papilloma in adult.


METHODS
Fifty samples from patients were selected and 10 cases of normal tissue or inflammation tissue were used as control group. The expression of Pgp, GST-pi, Topo II and Ki-67 and VEGF by immunohistochemical stain and the microvessel density by morphometry were studied.


RESULTS
(1) The positive rates of Pgp, GST-pi and Topo II were not correlated with the age, sex, tumor size and the recurrence (P > 0.05). (2) Both recurrent tissue and current tissue showed various positivity for Ki-67. The difference were significant (P < 0.01). Taking 39% of Ki-67 expression as threshold, there was significant difference between two curves indicating favorable recurrence in the tumor group respectively (P < 0.01). (3) Microvascular changes,such as the density of blood vessels demonstrated significantly difference between the two tumor group (P < 0.01). An average vessel count of more than 19 (x 200) suggested an easier recurrence.


CONCLUSIONS
Use of the cox-regression model in multivariate analysis shows that there are five parameters closely related to the recurrence of laryngeal papilloma in adult, of which the Ki-67 is the most critical factor, second the microvessel density, while Pgp, Topo II and GST-pi in tumor are independent favorable factors for laryngeal papilloma of adult.
Yao
Liqing
L
Department of Pathology, Fuzhou General Hospital of PLA, Fuzhou, 350001, China.
Chen
Xi
X
Yang
Jingsong
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000096:biosynthesis; D007822:Laryngeal Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000473:pathology; D010212:Papilloma / Q000378:metabolism / Q000473:pathology*; D016016:Proportional Hazards Models
D019394:Ki-67 Antigen