Derivation of genetic interaction networks from quantitative phenotype data.
We have generalized the derivation of genetic-interaction networks from quantitative phenotype data. Familiar and unfamiliar modes of genetic interaction were identified and defined. A network was derived from agar-invasion phenotypes of mutant yeast. Mutations showed specific modes of genetic interaction with specific biological processes. Mutations formed cliques of significant mutual information in their large-scale patterns of genetic interaction. These local and global interaction patterns reflect the effects of gene perturbations on biological processes and pathways.
Drees
Becky L
BL
Institute for Systems Biology, 1441 N, 34th Street, Seattle, WA 98103, USA. bdrees@u.washington.edu
Thorsson
Vesteinn
V
Carter
Gregory W
GW
Rives
Alexander W
AW
Raymond
Marisa Z
MZ
Avila-Campillo
Iliana
I
Shannon
Paul
P
Galitski
Timothy
T
D005800:Genes, Fungal / Q000235:genetics; D005823:Genetics; D005838:Genotype; D009154:Mutation / Q000235:genetics*; D010641:Phenotype; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism*