Brain-derived neurotrophic factor gene polymorphisms in Japanese patients with sporadic Alzheimer's disease, Parkinson's disease, and multiple system atrophy.
We studied two genetic polymorphisms (240C/T and 480G/A) of the brain-derived neurotrophic factor (BDNF) gene in Japanese patients with Alzheimer's disease (AD, n = 172), Parkinson's disease (PD, n = 327), and multiple system atrophy (MSA, n = 122), as well as controls (n = 275). The distribution of the 240 C/T polymorphism was significantly different between AD patients and controls, whereas there was no difference in the genotype of the two polymorphisms between MSA and controls or between PD and controls. Our data suggest that BDNF might play a role in AD.
Nishimura
Masataka
M
Clinical Research Center, Konan Hospital, Shiga, Japan. ma-nishi@vmail.plala.or.jp
Kuno
Sadako
S
Kaji
Ryuji
R
Kawakami
Hideshi
H
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D003545:Cysteine / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan / Q000208:ethnology; D008297:Male; D008715:Methionine / Q000235:genetics; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic; D013912:Threonine / Q000235:genetics; D014633:Valine / Q000235:genetics
D019208:Brain-Derived Neurotrophic Factor; D013912:Threonine; D008715:Methionine; D014633:Valine; D003545:Cysteine