Disseminated Scedosporium prolificans infection and survival of a child with acute lymphoblastic leukemia.
Scedosporium prolificans is a saprophytic fungus responsible for an increasing number of infections among immunocompromised hosts. Historically, disseminated infection with this organism has resulted in death. We report on a pediatric patient who developed overwhelming S. prolificans sepsis after induction chemotherapy for acute lymphoblastic leukemia. She is well 18 months after the diagnosis of fungal sepsis and continues to receive chemotherapy for leukemia, which remains in remission.
Whyte
Morag
M
Department of Pediatric Oncology, Banksia Unit, Royal Children's Hospital, Herston, Brisbane, Queensland, Australia 4029. morag_whyte@health.qld.gov.au
Irving
Helen
H
O'Regan
Peter
P
Nissen
Michael
M
Siebert
David
D
Labrom
Robert
R
D000935:Antifungal Agents / Q000627:therapeutic use; D002648:Child; D005260:Female; D016469:Fungemia / Q000188:drug therapy* / Q000382:microbiology*; D006801:Humans; D016867:Immunocompromised Host; D008271:Mycetoma / Q000188:drug therapy* / Q000382:microbiology*; D009281:Naphthalenes / Q000627:therapeutic use; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D011743:Pyrimidines / Q000627:therapeutic use; D021681:Scedosporium / Q000145:classification / Q000302:isolation & purification*; D000077291:Terbinafine; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
D000935:Antifungal Agents; D009281:Naphthalenes; D011743:Pyrimidines; D014230:Triazoles; D000077291:Terbinafine; D065819:Voriconazole