[Advances on biological activities of coumarins].
This paper reviewed the advances on effective constituents and biological activities of coumarins in recent ten years. Coumarins are a group of important natural compounds, and have been found to have multi-biological activities such as anti-HIV, anti-tumor, anti-hypertension, anti-arrhythmia, anti-osteoporosis, assuaging pain, preventing asthma and antisepsis. Therefore, further investigation should emphasize on improving techniques for extraction and separation, searching the effective precursory compound, and synthesizing and screening out courmarin derivatives with high activity and low toxicity.
Zhang
Shao-Yul
SY
Tianjin Medical University, Tianjin 300070, China. pharmgao@tju.edu.cn
Meng
Lin
L
Gao
Wen-Yuan
WY
Song
Nai-Ning
NN
Jia
Wei
W
Duan
Hong-Quan
HQ
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D019380:Anti-HIV Agents / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D003374:Coumarins / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D010946:Plants, Medicinal / Q000737:chemistry*
D000889:Anti-Arrhythmia Agents; D019380:Anti-HIV Agents; D000959:Antihypertensive Agents; D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins