title: Hymeniacidon perleve associated bioactive bacterium pseudomonas sp. NJ6-3-1.
abstract: Among the marine bacteria isolated from cytotoxic sponge Hymeniacidon perleve, one strain NJ6-3-1 classified as Pseudomonas sp. showed both cytotoxic and antimicrobial activities. Fatty acid analysis indicated that the bacterial strain consists mainly of C16:1, C16:0, C18:1, C18:0, C15:0, C14:0. One unusual 9,10-cyclopropane-C17:0 fatty acid, and C26:0 also constitute as major component as well as the existence of squalene, the precursor of triterpenoids. The major metabolites in the culture broth were identified as alkaloids, including diketopiperazines and indole compounds, namely 3,6-diisopropylpiperazin-2,5-dione, 3-benzyl-3-isopropylpiperazin-2,5-dione, 3,6-bis-(2-methylpropyl)-piperazin-2,5-dione, indole-3-carboxaldehyde, indole-3-caroxylic acid methyl ester, indole-3-ethanol, and quinazoline-2,4-dione.
authors.affiliation: Institute of Oceanology, Chinese Academy of Sciences, Graduate School of The Chinese Academy of Science, Qingdao 266071, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Zheng
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Yan
authors.forename: Jilin
authors.initials: J
authors.lastname: Xu
authors.forename: Haimin
authors.initials: H
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Lin
mesh_terms: D000818:Animals; D005227:Fatty Acids / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D008386:Marine Biology; D013058:Mass Spectrometry; D011161:Porifera / Q000382:microbiology*; D011549:Pseudomonas / Q000737:chemistry / Q000302:isolation & purification / Q000502:physiology*
chemical_list: D005227:Fatty Acids