title: Positive Tc-99m-MIBI scan in a patient with confirmed Paget's disease of bone.
abstract: A 46-year-old man was referred to our department for a Tc-99m MDP bone scan after he was admitted to our hospital with diffuse bone pain and the subsequent finding of multiple mixed type (lytic-blastic) lesions on routine x-rays. The Tc-99m MDP scan was highly suspicious for malignancy and, therefore, a Tc-99m MIBI scan was performed, which also revealed abnormal uptake in all regions with increased osteoblastic activity. Clinical chemistry and further workup revealed a highly elevated serum alkaline phosphatase and increased excretion of hydroxyproline in the urine. The presumed diagnosis of Paget's disease of the bone was further confirmed by biopsy.
authors.affiliation: St. Savas Oncology Hospital, Nuclear Medicine Department, and Dimokrition University of Thrace, School of Medicine, Nuclear Medicine Department, Athens, Greece.
authors.forename: Adonios
authors.initials: A
authors.lastname: Zanglis
authors.forename: Demetrios
authors.initials: D
authors.lastname: Andreopoulos
authors.forename: Athanassios
authors.initials: A
authors.lastname: Zissimopoulos
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Baziotis
mesh_terms: D001859:Bone Neoplasms / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000000981:diagnostic imaging* / Q000473:pathology*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi