title: Selegiline in the management of apathy following traumatic brain injury.
abstract: OBJECTIVE
  To provide a brief review of apathy following traumatic brain injury (TBI) and describe the use of selegiline in a group of patients with this symptom.
  
  
  RESULTS
  Four patients are described who showed improvement in Apathy Evaluation Scale scores and functional improvement, following the use of selegiline. In each case, selegiline was well tolerated whereas methylphenidate was not.
  
  
  CONCLUSIONS
  Selegiline shows potential for the management of apathy following TBI. This provides further evidence that impaired dopaminergic processes are prominent in the genesis of these symptoms. However, these findings require confirmation in controlled studies.
authors.affiliation: Rotorua Rehabilitation Clinic, Rotorua, New Zealand. dengil@xtra.co.nz
authors.forename: Gil
authors.initials: G
authors.lastname: Newburn
authors.forename: Deborah
authors.initials: D
authors.lastname: Newburn
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000150:complications / Q000523:psychology*; D015259:Dopamine Agents / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006040:Goals; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy* / Q000209:etiology; D009042:Motivation; D011581:Psychological Tests; D012642:Selegiline / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D015259:Dopamine Agents; D012642:Selegiline