title: Matrix implanted laser desorption ionization (MILDI) combined with ion mobility-mass spectrometry for bio-surface analysis.
abstract: The implantation of low velocity massive gold cluster ions allows homogeneous incorporation of a metallic matrix into the near-surface region of rat brain tissues. Subsequent analysis by laser desorption ionization mass spectrometry yields spectra exhibiting molecular ion peaks in the mass range up to 35 kDa similar to those observed by matrix-assisted LDI. Matrix-implanted LDI when combined with ion-mobility preseparation promises to be a useful technique for molecular imaging of biotissues with a laser microprobe.
authors.affiliation: Ionwerks, Inc., 2472 Bolsover St., Suite 255, Houston, Texas 77005, USA.
authors.forename: A
authors.initials: A
authors.lastname: Tempez
authors.forename: M
authors.initials: M
authors.lastname: Ugarov
authors.forename: T
authors.initials: T
authors.lastname: Egan
authors.forename: J A
authors.initials: JA
authors.lastname: Schultz
authors.forename: A
authors.initials: A
authors.lastname: Novikov
authors.forename: S
authors.initials: S
authors.lastname: Della-Negra
authors.forename: Y
authors.initials: Y
authors.lastname: Lebeyec
authors.forename: M
authors.initials: M
authors.lastname: Pautrat
authors.forename: M
authors.initials: M
authors.lastname: Caroff
authors.forename: V S
authors.initials: VS
authors.lastname: Smentkowski
authors.forename: H-Y J
authors.initials: HY
authors.lastname: Wang
authors.forename: S N
authors.initials: SN
authors.lastname: Jackson
authors.forename: A S
authors.initials: AS
authors.lastname: Woods
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D008055:Lipids / Q000737:chemistry; D008970:Molecular Weight; D010455:Peptides / Q000737:chemistry; D051381:Rats; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*; D013499:Surface Properties
chemical_list: D008055:Lipids; D010455:Peptides