title: "Tethered" Ru(II) catalysts for asymmetric transfer hydrogenation of ketones.
abstract: Stereochemically well-defined ruthenium(II) catalysts have been applied to the asymmetric transfer hydrogenation of a series of ketones. In one case, statistical experimental design was employed to optimize the enantiomeric excess of the product. In the case of the TsDPEN-based systems, the replacement of trans-1,2-diphenyl substitution with cis-, or deletion of one of the phenyl groups, results in significant deterioration of the enantiomeric excess. A new method is described for the synthesis of tethered amino alcohol-containing catalysts.
authors.affiliation: Department of Chemistry, University of Warwick, Coventry, CV4 7AL, United Kingdom.
authors.forename: Fung Kei Kathy
authors.initials: FK
authors.lastname: Cheung
authors.forename: Aidan M
authors.initials: AM
authors.lastname: Hayes
authors.forename: Jerome
authors.initials: J
authors.lastname: Hannedouche
authors.forename: Aveline S Y
authors.initials: AS
authors.lastname: Yim
authors.forename: Martin
authors.initials: M
authors.lastname: Wills