title: Diversifying vancomycin via chemoenzymatic strategies.
abstract: [reaction: see text] The rapid diversification of glycopeptides via glycorandomization reveals that significantly diverse substitutions are tolerated and suggests there may be a synergistic benefit to the construction of mechanistically related natural product core scaffold fusions. This work also further highlights the utility of chemoenzymatic approaches to diversify complex natural product architectures.
authors.affiliation: Laboratory for Biosynthetic Chemistry, Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Avenue, Madison, Wisconsin 53705, USA.
authors.forename: Xun
authors.initials: X
authors.lastname: Fu
authors.forename: Christoph
authors.initials: C
authors.lastname: Albermann
authors.forename: Changsheng
authors.initials: C
authors.lastname: Zhang
authors.forename: Jon S
authors.initials: JS
authors.lastname: Thorson
mesh_terms: D020650:Combinatorial Chemistry Techniques; D013293:Enterococcus faecalis / Q000378:metabolism; D016984:Enterococcus faecium / Q000378:metabolism; D005818:Genetic Engineering; D005964:Glucosyltransferases / Q000378:metabolism*; D006020:Glycopeptides / Q000737:chemistry*; D016106:Methicillin Resistance / Q000502:physiology; D015394:Molecular Structure; D012475:Salmonella / Q000378:metabolism; D013211:Staphylococcus aureus / Q000378:metabolism; D014640:Vancomycin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D006020:Glycopeptides; D014640:Vancomycin; D005964:Glucosyltransferases; C430144:glucosyltransferase E