title: Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells.
abstract: The control of damaging inflammation by the mucosal immune system in response to commensal and harmful ingested bacteria is unknown. Here we show epithelial cells conditioned mucosal dendritic cells through the constitutive release of thymic stromal lymphopoietin and other mediators, resulting in the induction of 'noninflammatory' dendritic cells. Epithelial cell-conditioned dendritic cells released interleukins 10 and 6 but not interleukin 12, and they promoted the polarization of T cells toward a 'classical' noninflammatory T helper type 2 response, even after exposure to a T helper type 1-inducing pathogen. This control of immune responses seemed to be lost in patients with Crohn disease. Thus, the intimate interplay between intestinal epithelial cells and dendritic cells may help to maintain gut immune homeostasis.
authors.affiliation: Department of Experimental Oncology, European Institute of Oncology, I-20141 Milan, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Rimoldi
authors.forename: Marcello
authors.initials: M
authors.lastname: Chieppa
authors.forename: Valentina
authors.initials: V
authors.lastname: Salucci
authors.forename: Francesca
authors.initials: F
authors.lastname: Avogadri
authors.forename: Angelica
authors.initials: A
authors.lastname: Sonzogni
authors.forename: Gianluca M
authors.initials: GM
authors.lastname: Sampietro
authors.forename: Angelo
authors.initials: A
authors.lastname: Nespoli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Viale
authors.forename: Paola
authors.initials: P
authors.lastname: Allavena
authors.forename: Maria
authors.initials: M
authors.lastname: Rescigno
mesh_terms: D002454:Cell Differentiation; D002478:Cells, Cultured; D003106:Colon / Q000166:cytology / Q000276:immunology; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D004847:Epithelial Cells / Q000276:immunology*; D005786:Gene Expression Regulation; D006706:Homeostasis / Q000276:immunology*; D006801:Humans; D018664:Interleukin-12 / Q000378:metabolism; D007422:Intestines / Q000166:cytology / Q000276:immunology*; D018417:Th1 Cells / Q000166:cytology / Q000276:immunology; D018418:Th2 Cells / Q000166:cytology / Q000276:immunology; D000094632:Thymic Stromal Lymphopoietin
chemical_list: D016207:Cytokines; D018664:Interleukin-12; D000094632:Thymic Stromal Lymphopoietin