title: Inflammatory actinic keratoses secondary to systemic chemotherapy.
abstract: Traditionally, systemic 5-fluorouracil has been associated with a reaction that produces inflammation of preexisting and subclinical actinic keratoses (AKs). We report a case of an inflammatory reaction occurring in AKs secondary to the use of doxorubicin. The cutaneous reaction was successfully managed with the application of high-potency topical steroids over the body and with pain management. When the doxorubicin was discontinued and another agent (paclitaxel) was instituted, the cutaneous reaction gradually diminished.
authors.affiliation: Division of Dermatology, Department of Medicine, Cooper Health System, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, USA.
authors.forename: Erum N
authors.initials: EN
authors.lastname: Ilyas
authors.forename: Generosa
authors.initials: G
authors.lastname: Grana
authors.forename: Justin J
authors.initials: JJ
authors.lastname: Green
mesh_terms: D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy; D004317:Doxorubicin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007642:Keratosis / Q000188:drug therapy / Q000209:etiology*; D008875:Middle Aged; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D000305:Adrenal Cortex Hormones; D000970:Antineoplastic Agents; D004317:Doxorubicin