title: The role of immune reconstitution inflammatory syndrome in AIDS-related Cryptococcus neoformans disease in the era of highly active antiretroviral therapy.
abstract: This study of human immunodeficiency virus (HIV)-infected patients coinfected with Cryptococcus neoformans found that 30% of patients who initiated highly active antiretroviral therapy developed immune reconstitution inflammatory syndrome (IRIS). Patients with C. neoformans-related IRIS had higher cerebrospinal fluid opening pressures, glucose levels, and white blood cell counts, compared with patients with typical HIV-associated C. neoformans meningitis.
authors.affiliation: Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA. samuels@bcm.tmc.edu
authors.forename: Samuel A
authors.initials: SA
authors.lastname: Shelburne
authors.forename: Jorge
authors.initials: J
authors.lastname: Darcourt
authors.forename: A Clinton
authors.initials: AC
authors.lastname: White
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Greenberg
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Hamill
authors.forename: Robert L
authors.initials: RL
authors.lastname: Atmar
authors.forename: Fehmida
authors.initials: F
authors.lastname: Visnegarwala
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D019380:Anti-HIV Agents / Q000009:adverse effects; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D003453:Cryptococcosis / Q000209:etiology*; D006801:Humans; D007249:Inflammation / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology*; D012008:Recurrence
chemical_list: D019380:Anti-HIV Agents