[Expression and significance of PTEN and caspase-3 in laryngeal squamous cell carcinoma].
OBJECTIVE
To elucidate the expression and significance of PTEN and Caspase-3 in laryngeal squamous cell carcinoma.


METHODS
Immunochemical method was used to study 289 cases of laryngeal carcinoma, including 60 cases atypical hyperplasia of vocal fold and 20 cases of normal laryngeal tissues.


RESULTS
The PTEN gene was expressed in 58.8% laryngeal carcinoma tissues, in 86.7% atypical hyperplasia of vocal fold and 100.0% normal laryngeal tissues. The differences were significance (P < 0.05). The Caspase-3 was expressed in 48.1% laryngeal carcinoma tissues, in 61.7% atypical hyperplasia of vocal fold and in 85.0% normal laryngeal tissues. The differences were significance (P < 0.05). In addition, there was a positive correlation between the expression of Caspase-3 and PTEN (P < 0.01).


CONCLUSIONS
Expression of PTEN and Caspase-3 in laryngeal carcinoma is different from that of normal laryngeal tissues, which may play an important role in the tumorigenesis and development of laryngeal carcinoma.
Li
Changqing
C
Department of Otorhinolaryngology, the Second Clinical Hospital of Jilin University, Changchun, 130041, China.
Jin
Chunshun
C
Zhang
Ling
L
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D053148:Caspase 3 / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008565:Membrane Proteins / Q000096:biosynthesis*; D008875:Middle Aged; D051059:PTEN Phosphohydrolase / Q000096:biosynthesis*
D008565:Membrane Proteins; C446603:TPTE protein, human; D051059:PTEN Phosphohydrolase; D053148:Caspase 3