title: Intraventricular albumin: an optional agent in experimental post-traumatic brain edema.
abstract: OBJECTIVE
  Human albumin may be effective in the treatment of posttraumatic brain edema due to its hyperoncotic features. Therefore, the aim of the experimental study presented in this paper has two points: the first is to evaluate the efficacy of intraventricular hyperoncotic human albumin on post-traumatic brain edema and the second is to try to show the appropriate posttraumatic time window for albumin administration.
  
  
  METHODS
  Traumatic brain injury and subsequent edema was formed by a model of impact acceleration injury in rats. Human albumin was administered via intraventricular route by using a stereotactic head holder. All animals in each group were decapitated 24 hours after the procedure and the effect of albumin was evaluated by measurement of tissue specific gravity.
  
  
  RESULTS
  Tissue specific gravity decreased in edematous tissue (trauma indicator), increased after albumin administration at the 12th (p < 0.001), and both at the 1st and 12th hour of the trauma (edema treatment; p < 0.001). On the other hand, albumin administered at the 12th, and at both the 1st and 12th hours in the rats without trauma has caused the formation of the brain edema.
  
  
  CONCLUSIONS
  We conclude that human albumin is effective in cytotoxic, but not in vasogenic edema and exerts its best anti-edematous effect at the 12th hour of severe head trauma and this study may help future studies that will try to show the effects of albumin with different time modalities after severe head injury.
authors.affiliation: Department of Neurosurgery, Medical Faculty, Duzce Izzet Baysal University, Duzce, Turkey.
authors.forename: Merih
authors.initials: M
authors.lastname: Is
authors.forename: Mustafa
authors.initials: M
authors.lastname: Uzan
authors.forename: Faruk
authors.initials: F
authors.lastname: Unal
authors.forename: Talat
authors.initials: T
authors.lastname: Kiris
authors.forename: Taner
authors.initials: T
authors.lastname: Tanriverdi
authors.forename: Murat
authors.initials: M
authors.lastname: Mengi
authors.forename: Nurten
authors.initials: N
authors.lastname: Kilic
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001929:Brain Edema / Q000209:etiology / Q000628:therapy*; D001930:Brain Injuries / Q000150:complications / Q000628:therapy*; D004195:Disease Models, Animal; D006801:Humans; D007276:Injections, Intraventricular / Q000379:methods; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012709:Serum Albumin / Q000008:administration & dosage*; D013046:Specific Gravity / Q000187:drug effects; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D012709:Serum Albumin