title: [Biological and evolutive spectrum of patients ANCA present].
abstract: OBJECTIVE
  To analyse the immuno-biological profile of patients with antineutrophil cytoplasmic antibodies (ANCA) presents. This is a retrospective study of all ANCA positives cases from Nephrology Clinic Iasi during five years (1998-2003) on a cohort of 97 patients.
  
  
  RESULTS
  pANCA was positive in 28, cANCA was positive in 60 and the others had pANCA and cANCA. The diseases ANCA associated were: systemic vasculitis, rapidly progressive glomerulonephritis (GNRP), chronic renal failure of an unknown etiology. ANCA presence was associated with inflammatory syndrome in 83.5%, anemic syndrome in 71.1%. From the patients with renal disfunction (71.1%), half of them presented an increased level of creatinine (>6 mg%). Renal biopsy proven especially crescentic glomerulonephritis. The complications and the diseases were more frequent in cANCA cases.
  
  
  CONCLUSIONS
  cANCA presence is a negative prognosis factor in vasculitis; testing ANCA alone cannot be used to guide treatment.
authors.affiliation: Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi, Facultatea de Medicină, Clinica a IV-a Medicală-Nefrologie.
authors.forename: A
authors.initials: A
authors.lastname: Covic
authors.forename: Camelia
authors.initials: C
authors.lastname: Mutică
authors.forename: Anamaria
authors.initials: A
authors.lastname: Ignat
authors.forename: Iulia
authors.initials: I
authors.lastname: Boaru
authors.forename: G
authors.initials: G
authors.lastname: Veisa
authors.forename: Maria
authors.initials: M
authors.lastname: Enea
authors.forename: Maria
authors.initials: M
authors.lastname: Covic
mesh_terms: D000328:Adult; D000465:Algorithms; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D005260:Female; D005921:Glomerulonephritis / Q000097:blood / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014657:Vasculitis / Q000097:blood / Q000276:immunology*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D015415:Biomarkers