Inflammation in juvenile idiopathic arthritis.
Inflammation evolved to aid in the clearance of microorganisms. In pediatric arthritides, the inflammation persists and causes damage to the joint. The contribution of the innate immune system to inflammation is significant and can be exploited therapeutically. Although cells of the adaptive immune system such as T cells and B cells participate in the disease process, many of the features of arthritis are directly attributable to inflammatory mediators. Recent advances in the understanding of these processes have led to dramatic improvements in treatment.
Sullivan
Kathleen E
KE
University of Pennsylvania School of Medicine, Division of Allergy and Immunology, Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA. sullivak@mail.med.upenn.edu
D000222:Adaptation, Physiological; D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001171:Arthritis, Juvenile / Q000145:classification / Q000188:drug therapy / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D018925:Chemokines / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology; D007378:Interleukins / Q000276:immunology; D015289:Leukotrienes / Q000276:immunology; D008285:Major Histocompatibility Complex / Q000276:immunology; D008407:Mast Cells / Q000276:immunology; D009000:Monocytes / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D018925:Chemokines; D006680:HLA Antigens; D007378:Interleukins; D015289:Leukotrienes; D014409:Tumor Necrosis Factor-alpha