title: Ocular metastasis as first presentation of renal cell carcinoma: report of 2 cases.
abstract: Authors report the cases of 2 patients who had an ocular lesion as the first sign leading to diagnosis of renal cell carcinoma, an uncommon presentation of this neoplasm. The first patient was a 59-year-old man presented with a mass in the right eye. The histological and immunohistochemical profile of the biopsy showed a probable renal cell carcinoma. A CT scan showed a solid mass in the left kidney. The patient underwent radical nephrectomy and excision of the ocular lesion and had an uneventful evolution. The second patient was a 72-year-old man presenting with an ulcerated lesion on the right inferior tarsal conjunctiva. An excisional biopsy of the lesion showed histological and immunohistochemical patterns of a clear cell carcinoma. Abdominal tomography disclosed a right peripheral renal tumor. A right radical nephrectomy was performed. Renal cell carcinoma may present atypically with metastases to quite uncommon organs. Nephrectomy may be of value in selected cases; the ocular metastases are usually excised for aesthetic and functional reasons.
authors.forename: Antonio Carlos Lima
authors.initials: AC
authors.lastname: Pompeu
authors.forename: Sami
authors.initials: S
authors.lastname: Arap
authors.forename: Matheus Neves R
authors.initials: MN
authors.lastname: Silva
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Monteiro
mesh_terms: D000368:Aged; D001706:Biopsy; D002292:Carcinoma, Renal Cell / Q000556:secondary*; D005134:Eye Neoplasms / Q000556:secondary*; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged