title: Efficient pipeline for image-based patient-specific analysis of cerebral aneurysm hemodynamics: technique and sensitivity.
abstract: Hemodynamic factors are thought to be implicated in the progression and rupture of intracranial aneurysms. Current efforts aim to study the possible associations of hemodynamic characteristics such as complexity and stability of intra-aneurysmal flow patterns, size and location of the region of flow impingement with the clinical history of aneurysmal rupture. However, there are no reliable methods for measuring blood flow patterns in vivo. In this paper, an efficient methodology for patient-specific modeling and characterization of the hemodynamics in cerebral aneurysms from medical images is described. A sensitivity analysis of the hemodynamic characteristics with respect to variations of several variables over the expected physiologic range of conditions is also presented. This sensitivity analysis shows that although changes in the velocity fields can be observed, the characterization of the intra-aneurysmal flow patterns is not altered when the mean input flow, the flow division, the viscosity model, or mesh resolution are changed. It was also found that the variable that has the greater impact on the computed flow fields is the geometry of the vascular structures. We conclude that with the proposed modeling pipeline clinical studies involving large numbers cerebral aneurysms are feasible.
authors.affiliation: School of Computational Sciences, George Mason University, 4400 University Drive, MSN 4C7, Fairfax, VA 22030, USA. jcebral@gmu.edu
authors.forename: Juan R
authors.initials: JR
authors.lastname: Cebral
authors.forename: Marcelo A
authors.initials: MA
authors.lastname: Castro
authors.forename: Sunil
authors.initials: S
authors.lastname: Appanaboyina
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Putman
authors.forename: Daniel
authors.initials: D
authors.lastname: Millan
authors.forename: Alejandro F
authors.initials: AF
authors.lastname: Frangi
mesh_terms: D000465:Algorithms; D001783:Blood Flow Velocity; D001794:Blood Pressure; D001809:Blood Viscosity; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging / Q000503:physiopathology; D002533:Cerebral Angiography / Q000379:methods*; D003198:Computer Simulation; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods*; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008955:Models, Cardiovascular; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity