Childhood case of progressive multifocal leukoencephalopathy with improved clinical outcome.
A 6-year-old boy who had been in remission from acute lymphoblastic leukemia for 2.5 years presented with seizures, hemiparesis, visual loss, and white- and gray-matter lesions on cranial magnetic resonance imaging. The diagnosis of progressive multifocal leukoencephalopathy was established on the detection of JC virus DNA by polymerase chain reaction in brain tissue. The patient was administered several anticonvulsants, amantadine, acyclovir, and ganciclovir. He showed partial recovery. This case illustrates the possibility of long-term survival in progressive multifocal leukoencephalopathy with normal immunologic parameters.
Demir
Ercan
E
Department of Pediatric Neurology, Hacettepe University, Ankara, Turkey.
Liebert
Uwe G
UG
Söylemezoglu
Figen
F
Yalaz
Kalbiye
K
Köse
Gülsen
G
Anlar
Banu
B
D000927:Anticonvulsants / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D002648:Child; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D017741:Survivors
D000927:Anticonvulsants; D000998:Antiviral Agents