title: Trophoblast apoptosis is increased in women with evidence of TH1 immunity.
abstract: Interferon-gamma secretion from peripheral blood mononuclear cells (PBMCs) of women with unexplained recurrent spontaneous abortions was increased by trophoblast stimulation. Apoptosis was significantly increased in trophoblast cells cultured with the supernatant of PBMCs from women with evidence of T(H)1 immunity to trophoblast stimulation.
authors.affiliation: Laboratory of Reproductive Medicine, Center for Recurrent Miscarriage and Infertility, Creation and Love Women's Hospital, Kwangju Institute of Science and Technology (K-JIST), 13-21 Gwangchun-Dong, Seo-Gu, Gwangju 502-210, Korea.
authors.forename: Jiae
authors.initials: J
authors.lastname: Lee
authors.forename: Bum-Chae
authors.initials: BC
authors.lastname: Choi
authors.forename: Chunghee
authors.initials: C
authors.lastname: Cho
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Hill
authors.forename: Kwang-Hyun
authors.initials: KH
authors.lastname: Baek
authors.forename: Jeong-Wook
authors.initials: JW
authors.lastname: Kim
mesh_terms: D000026:Abortion, Habitual / Q000276:immunology*; D017209:Apoptosis / Q000276:immunology*; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D011247:Pregnancy; D018417:Th1 Cells / Q000276:immunology* / Q000378:metabolism; D014327:Trophoblasts / Q000276:immunology* / Q000473:pathology*
chemical_list: D007371:Interferon-gamma