Nanoscale size effect of magnetic nanocrystals and their utilization for cancer diagnosis via magnetic resonance imaging.
Since the use of magnetic nanocrystals as probes for biomedical system is attractive, it is important to develop optimal synthetic protocols for high-quality magnetic nanocrystals and to have the systematic understanding of their nanoscale properties. Here we present the development of a synthetically controlled magnetic nanocrystal model system that correlates the nanoscale tunabilities in terms of size, magnetism, and induced nuclear spin relaxation processes. This system further led to the development of high-performance nanocrystal-antibody probe systems for the diagnosis of breast cancer cells via magnetic resonance imaging.
Jun
Young-Wook
YW
Department of Chemistry, Yonsei University, Seoul 120-749, Korea.
Huh
Yong-Min
YM
Choi
Jin-Sil
JS
Lee
Jae-Hyun
JH
Song
Ho-Taek
HT
Kim
Sungjun
S
Yoon
Sarah
S
Kim
Kyung-Sup
KS
Shin
Jeon-Soo
JS
Suh
Jin-Suck
JS
Cheon
Jinwoo
J
D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry; D061067:Antibodies, Monoclonal, Humanized; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D001943:Breast Neoplasms / Q000175:diagnosis*; D045744:Cell Line, Tumor; D006801:Humans; D007501:Iron / Q000737:chemistry; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics; D049329:Nanostructures / Q000737:chemistry*; D013440:Sulfides / Q000737:chemistry; D000068878:Trastuzumab
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D001672:Biocompatible Materials; D013440:Sulfides; C111959:greigite; D007501:Iron; D000068878:Trastuzumab