title: [Quantitative evaluation of canine renal blood flow with contrast-enhanced ultrasound].
abstract: OBJECTIVE
  To evaluate the accuracy of contrast-enhanced ultrasound (CEU) in renal blood flow quantification.
  
  
  METHODS
  Regional renal perfusion was quantified with CEU in 10 dogs at the baseline level and after treatment with 3 doses of dopamine (3, 8 and 16 mg.kg(-1).min(-1)), and renal arterial flow (RAF) was measured with ultrasonic flow probes deployed directly on the renal artery simultaneously. Normalized RAF was calculated as RAF divided by renal weight (ml.min(-1).g(-1)).
  
  
  RESULTS
  Compared with the baseline level, a progressive increase in RAF was induced by dopamine treatment at the doses of 3 and 8 mg.kg(-1).min(-1) (P<0.05), but at a higher dose of 16 mg.kg(-1).min(-1), the increment in RAF was reduced in comparison with that with the two lower doses (P<0.05). The same changes in cortical nutrient blood flow derived from CEU were observed. Significant positive correlation was found between normalized RAF and CEU-derived cortical nutrient blood flow (y=39.8x + 44.3, r=0.88, P<0.001).
  
  
  CONCLUSIONS
  CEU can be used to accurately quantify renal blood flow in dogs.
authors.affiliation: Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. xwx@fimmu.com
authors.forename: Wen-Xing
authors.initials: WX
authors.lastname: Xiao
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Bin
authors.forename: Jin-Guo
authors.initials: JG
authors.lastname: Xie
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.forename: Dao-Gang
authors.initials: DG
authors.lastname: Cha
authors.forename: Ding-Li
authors.initials: DL
authors.lastname: Xu
mesh_terms: D000818:Animals; D003287:Contrast Media; D004285:Dogs; D004298:Dopamine / Q000494:pharmacology; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D007668:Kidney / Q000000981:diagnostic imaging*; D012039:Regional Blood Flow; D012079:Renal Circulation / Q000502:physiology*; D014463:Ultrasonography
chemical_list: D003287:Contrast Media; D004298:Dopamine