title: Subsequent development of thrombocytopenia and coagulopathy in moderate and severe head injury: support for serial laboratory examination.
abstract: BACKGROUND
  Patients with moderate and severe traumatic brain injury (TBI) are at risk for secondary brain insults such as thrombocytopenia and coagulopathy. This study assessed the development of thrombocytopenia and coagulopathy at admission and within the subsequent 72 hours after TBI.
  
  
  METHODS
  Blunt trauma patients with moderate or severe TBI and an extracranial Abbreviated Injury Scale score less than 3 were reviewed. Data collection included initial and subsequent prothrombin time, partial thromboplastin time, and platelet values.
  
  
  RESULTS
  On initial evaluation, thrombocytopenia was present in 14% and coagulopathy in 21% of patients. By the third day, thrombocytopenia and coagulopathy increased to 46% and 41%, respectively. Of patients who died, 67% had thrombocytopenia and 62% had coagulopathy.
  
  
  CONCLUSIONS
  Patients with moderate and severe TBI are at risk for thrombocytopenia and coagulopathy, not only at admission but also on subsequent laboratory examination. Repeat laboratory evaluation is warranted even if initial results are normal in this population.
authors.affiliation: Michel E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA. mcarrick@bcm.tmc.edu
authors.forename: Matthew M
authors.initials: MM
authors.lastname: Carrick
authors.forename: Alan H
authors.initials: AH
authors.lastname: Tyroch
authors.forename: Cortney A
authors.initials: CA
authors.lastname: Youens
authors.forename: Taylor
authors.initials: T
authors.lastname: Handley
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001778:Blood Coagulation Disorders / Q000175:diagnosis / Q000209:etiology*; D002648:Child; D006259:Craniocerebral Trauma / Q000150:complications*; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013921:Thrombocytopenia / Q000175:diagnosis / Q000209:etiology*; D013997:Time Factors