YM-216391, a novel cytotoxic cyclic peptide from Streptomyces nobilis. I. fermentation, isolation and biological activities.
YM-216391, a novel cyclic peptide, was isolated from the cultured mycelium of Streptomyces nobilis JCM 4274. It was purified by solvent extraction, silica gel and ODS flash column chromatographies, followed by preparative HPLC. YM-216391 dose-dependently inhibited the growth of human cervical cancer HeLa S3 cells with an IC50 value of 14nM. YM-216391 also showed potent cytotoxic activity against a human cancer cell line panel.
Sohda
Kin-ya
KY
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Itabashi-ku, Tokyo 174-8511, Japan. souda@yamanouchi.co.jp
Nagai
Koji
K
Yamori
Takao
T
Suzuki
Ken-ichi
K
Tanaka
Akihiro
A
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces
D000970:Antineoplastic Agents; D010080:Oxazoles; D010456:Peptides, Cyclic; C499972:YM 216391