[The role of initial state of adrenal cortex in external irradiation effects upon its structure, function and androgen-receptor interactions].
We studied morphological-biochemical time-course reactions of adrenal cortex and hormonal function of testicles after combined or separate actions of external radiation exposure (1.0 Gy at 7.8 x 10(-4) Gy/sec) and prolonged (12-, 32 days) subcutaneous corticosterone injections (10 mg/kg/animal) in 2-3-month old male rats. Both variants with exogenous hormone depressed endogenous glucocorticoid production and evolved acute structure-functional adrenal gland cortex deficiency. Radiocensitivity of the gland at the experimental conditions was increased. Simultaneously the aggravation of adrenal cortex functional activity accompanied with hypogonadism and depressed reproductive potential of male rats, accessed by means of androgen status and androgenspecific (transporting and receptional) proteins characteristics as sensitive molecular markers of an animal possible fecundity.
Konoplia
E F
EF
Banetskaia
N V
NV
Popov
E G
EG
Rubchenia
I N
IN
D000302:Adrenal Cortex / Q000166:cytology / Q000502:physiology* / Q000528:radiation effects*; D000728:Androgens / Q000378:metabolism*; D000818:Animals; D003345:Corticosterone / Q000097:blood / Q000494:pharmacology; D005720:Gamma Rays; D005938:Glucocorticoids / Q000502:physiology; D007006:Hypogonadism / Q000378:metabolism; D008297:Male; D011836:Radiation Tolerance / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011944:Receptors, Androgen / Q000378:metabolism; D013737:Testis / Q000378:metabolism / Q000528:radiation effects; D013739:Testosterone / Q000097:blood / Q000378:metabolism
D000728:Androgens; D005938:Glucocorticoids; D011944:Receptors, Androgen; D013739:Testosterone; D003345:Corticosterone