title: Association of prothrombin gene mutation with sepsis in a preterm with multiple intracardiac thrombi.
abstract: We report for the first time, a premature infant with multiple intracardiac thrombi and sepsis, who was heterozygous for the G20210A prothrombin gene variant. Anticoagulant treatment with low molecular weight heparin resulted in the complete disappearance of the thrombi. It may be suggested that prothrombin gene variant associated with sepsis, respiratory distress syndrome, and perinatal asphyxia, as well as other thrombophilic disorders, could be a risk factor for the development of neonatal thrombus.
authors.affiliation: Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey. acinar@hacettepe.edu.tr
authors.forename: Asli
authors.initials: A
authors.lastname: Cinar
authors.forename: Embiya
authors.initials: E
authors.lastname: Dilber
authors.forename: Tevfik
authors.initials: T
authors.lastname: Karagoz
authors.forename: Nursat
authors.initials: N
authors.lastname: Bahadir
authors.forename: Safak
authors.initials: S
authors.lastname: Gucer
authors.forename: Gulsevin
authors.initials: G
authors.lastname: Tekinalp
authors.forename: Aytemiz
authors.initials: A
authors.lastname: Gurgey
mesh_terms: D018450:Disease Progression; D017809:Fatal Outcome; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D006331:Heart Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D009154:Mutation; D011110:Polymorphism, Genetic; D011516:Prothrombin / Q000235:genetics*; D018805:Sepsis / Q000150:complications / Q000175:diagnosis*; D012720:Severity of Illness Index; D013923:Thromboembolism / Q000150:complications / Q000000981:diagnostic imaging / Q000235:genetics*; D014463:Ultrasonography
chemical_list: D011516:Prothrombin