[Purification of small peptide from Agkistrodon blomhoffii Bioe and its inhibition on platelet aggregation].
This is the first report to purify a new peptide SV-PP-1 from Agkistrodon blomhoffii Bioe. SV-PP-1 has molecular weight of 1234.616 Da and can inhibit on platelet aggregation. SV-PP-1 significantly inhibited the ADP-induced platelet aggregation. It has been found up to now that SV-PP-1 is the smallest peptide inhibiting on platelet aggregation from snake venom.
Wu
Shaoyu
S
Institute of Pharmaceutical Sciences, First Military Medical University, Guangzhou.
Li
Zhiqin
Z
Zhang
Jiajie
J
Xu
Wei
W
Zhu
Zhengguang
Z
Yu
Chuanlin
C
Wu
Shuguang
S
D017836:Agkistrodon; D000595:Amino Acid Sequence; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D008419:Materia Medica / Q000302:isolation & purification / Q000494:pharmacology*; D008970:Molecular Weight; D010455:Peptides / Q000302:isolation & purification* / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D011817:Rabbits; D012910:Snake Venoms / Q000737:chemistry*
D008419:Materia Medica; D010455:Peptides; D010975:Platelet Aggregation Inhibitors; D012910:Snake Venoms