title: [Increase in the incidence of pertussis and quality of whole-cell pertussis component of the DTP vaccine produced in Poland. Part I. Potency of DTP vaccine].
abstract: This study aimed to identify and to evaluate the level of potency fluctuations of the pertussis component of Polish-produced DTP vaccine lots produced within 1972-2001 due to the changes having occurred in production and potency testing procedures. The study confirms that higher potency values were obtained for vaccine lots produced since 80-ties, e.g. after changes of: references lots (1975), vaccine strains (1978) and source of animals used in Kendrick tests (1979). Additionally, the comparisons performed revealed a down trend in potency levels within 1992-1999 correlating to the lowering of the number of IOU/dose.
authors.affiliation: Zakład Badania Surowic i Szczepionek PZH, Warszawa.
authors.forename: Anna
authors.initials: A
authors.lastname: Gzyl
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Gniadek
authors.forename: Ewa
authors.initials: E
authors.lastname: Augustynowicz
authors.forename: Daniel
authors.initials: D
authors.lastname: Rabczenko
authors.forename: Barbara
authors.initials: B
authors.lastname: Husejnow
authors.forename: Monika
authors.initials: M
authors.lastname: Zawadka
authors.forename: Janusz
authors.initials: J
authors.lastname: Slusarczyk
mesh_terms: D000818:Animals; D000917:Antibody Formation; D001886:Bordetella pertussis / Q000276:immunology; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000276:immunology* / Q000592:standards*; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D015994:Incidence; D011044:Poland / Q000453:epidemiology; D012189:Retrospective Studies; D013997:Time Factors; D014917:Whooping Cough / Q000453:epidemiology* / Q000276:immunology* / Q000517:prevention & control
chemical_list: D015721:Diphtheria-Tetanus-Pertussis Vaccine