title: An autopsy case of Brugada syndrome with significant lesions in the sinus node.
abstract: A 30-year-old man with Brugada syndrome died suddenly. The heart weighed 380 g. The left ventricular wall showed mild thickening, and marked fatty tissue deposition was noted in the right ventricular outflow tract. Neither ventricle was enlarged. Contraction band necrosis was diffuse in both ventricles. In the ventricles no cardiac muscle cell hypertrophy or atrophy, or significant interstitial fibrosis was observed. In the sinus node the number of nodal cells was reduced by half, with fatty tissue and fibrosis prominent. But no lesions were evident in the right bundle branch.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan. morimoto@fujita-hu.ac.jp
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Morimoto
authors.forename: Akihisa
authors.initials: A
authors.lastname: Uemura
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Hishida
mesh_terms: D000328:Adult; D001344:Autopsy; D002037:Bundle-Branch Block / Q000150:complications / Q000473:pathology*; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D004562:Electrocardiography; D017809:Fatal Outcome; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications / Q000473:pathology*; D008297:Male; D012849:Sinoatrial Node / Q000473:pathology*; D013575:Syncope; D013577:Syndrome; D014693:Ventricular Fibrillation / Q000150:complications / Q000473:pathology*