Nogo CAA 3'UTR Insertion polymorphism is not associated with Schizophrenia nor with bipolar disorder.
The Nogo gene maps to 2p14-p13, a region consistently associated with schizophrenia and bipolar disorder. The association of a polymorphism in Nogo was previously investigated by two groups, with divergent results. In this report, using an alternative approach, we evaluated this same polymorphism in 725 individuals, including patients with schizophrenia, bipolar disorder, normal controls and non-human primate samples. Our results indicate that the polymorphism is not associated with any of these diseases, but has a remarkably biased distribution in ethnic groups. Genotyping of primate samples, suggest that this polymorphism is a recent event in human speciation.
Gregório
Sheila P
SP
Laboratory of Neurosciences (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Mury
Fábio B
FB
Ojopi
Elida B
EB
Sallet
Paulo C
PC
Moreno
Doris H
DH
Yacubian
Juliana
J
Tavares
Hildeberto
H
Santos
Fabrício R
FR
Gattaz
Wagner F
WF
Dias-Neto
Emmanuel
E
D000328:Adult; D000818:Animals; D001714:Bipolar Disorder / Q000208:ethnology / Q000235:genetics*; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D004251:DNA Transposable Elements; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D000882:Haplorhini / Q000235:genetics; D006801:Humans; D008297:Male; D016254:Mutagenesis, Insertional; D009185:Myelin Proteins / Q000235:genetics*; D000070798:Nogo Proteins; D011110:Polymorphism, Genetic; D044469:Racial Groups / Q000235:genetics; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*; D020506:Untranslated Regions
D004251:DNA Transposable Elements; D009185:Myelin Proteins; D000070798:Nogo Proteins; C000603199:RTN4 protein, human; D020506:Untranslated Regions