T cell homeostasis: keeping useful T cells alive and live T cells useful.
It has become clear that the regulation of T cell numbers is under peripheral homeostatic control. However, the rules for homeostasis vary with the T cells' differentiation state and the overall T cell number in the animal. Furthermore, homeostatic pressures can cause unexpected changes in T cell differentiation and function which might promote or dampen T cell reactivity. In this review, we focus on the role of peptide/MHC and cytokine interactions in regulating the size and composition of the T cell pool.
Jameson
Stephen C
SC
Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, MN, USA. james024@umn.edu
D000818:Animals; D016207:Cytokines / Q000378:metabolism; D005786:Gene Expression Regulation; D006649:Histocompatibility Antigens / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007156:Immunologic Memory; D008024:Ligands; D008231:Lymphopenia / Q000276:immunology / Q000473:pathology; D051379:Mice; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000502:physiology*
D016207:Cytokines; D006649:Histocompatibility Antigens; D008024:Ligands