title: The internal dynamic modes of charged self-assembled peptide fibrils.
abstract: Photon correlation spectroscopy is used to study the internal dynamics of self-assembled charged peptide fibrils. Short neutral and charged polymeric aggregates have diffusive modes due to whole macromolecular motion. For long semiflexible fibrils the logarithm of the intermediate scattering function follows a q(2)t(3/4) scaling at long times consistent with a Kratky-Porod free energy and preaveraged Oseen hydrodynamics. Persistence lengths on the order of micrometers are calculated for the peptide fibrils consistent with estimates from the liquid-crystalline phase behavior. Fibril diameters (5-35 nm) calculated from the initial decay of the correlation functions are in agreement with transmission electron microscopy measurements.
authors.forename: L
authors.initials: L
authors.lastname: Carrick
authors.forename: M
authors.initials: M
authors.lastname: Tassieri
authors.forename: T A
authors.initials: TA
authors.lastname: Waigh
authors.forename: A
authors.initials: A
authors.lastname: Aggeli
authors.forename: N
authors.initials: N
authors.lastname: Boden
authors.forename: C
authors.initials: C
authors.lastname: Bell
authors.forename: J
authors.initials: J
authors.lastname: Fisher
authors.forename: E
authors.initials: E
authors.lastname: Ingham
authors.forename: R M L
authors.initials: RM
authors.lastname: Evans
mesh_terms: D000465:Algorithms; D044085:Microfluidics; D046529:Microscopy, Electron, Transmission; D008958:Models, Molecular; D036103:Nanotechnology; D010446:Peptide Fragments / Q000737:chemistry* / Q000648:ultrastructure; D012542:Scattering, Radiation; D013816:Thermodynamics
chemical_list: D010446:Peptide Fragments