title: LDL-apheresis accelerates the recovery of nonarteritic acute anterior ischemic optic neuropathy.
abstract: Nonarteritic acute anterior ischemic optic neuropathy (NAION) is a disabling disease which impairs visual function. It is presumed to result from disturbances of microcirculation in the anterior portion of the optic nerve head due to hemodynamic factors derived from excessive blood viscosity, or restriction of the vasal lumen in hypertensive, hypercholesterolemic, diabetic patients. We aimed to determine whether acute reduction of plasma fibrinogen and serum low-density lipoprotein (LDL) cholesterol is effective for treatment of NAION. We recruited 11 patients (7 females, 4 males) with a mean age of 57.2 +/- 19.6 years. All except one of them presented risk factors for atherosclerosis. The mean values of LDL-cholesterol and fibrinogen before treatment were 144 +/- 32 mg/dL and 341 +/- 80 mg/dL, respectively. All were treated with standard therapy (prednisone, salicylate, pentoxiphyllin) and underwent three sessions of LDL-apheresis (HELP system-B Braun) that can reduce plasma LDL-cholesterol and fibrinogen by more than 50% in a very short time. In all patients we observed a drastic reduction of LDL cholesterol and fibrinogen and a clear improvement in the visual functional data. In fact, mean values of corrected vision increased from 3.7/10 +/- 3/10 to 7.9/10 +/- 2.2/10 (P = 0.002) after the third session, while the scotomatous portion of the visual field regressed after the first session, and in 5 patients further regressed after the third session. This improvement had remained stable after 3 months. Thanks to it's effect of antagonizing hemorheologic disorders of the ocular microcirculation, fibrinogen/LDL-apheresis seems to be an efficacious treatment of NAION.
authors.affiliation: Division of Nephrology, Department of Internal and Public Medicine, Universit of Bari, Piazza Giulio Cesare, 11, 70124 Bari, Italy. a.ramunni@nephro.uniba.it
authors.forename: Alfonso
authors.initials: A
authors.lastname: Ramunni
authors.forename: Giovanni
authors.initials: G
authors.lastname: Giancipoli
authors.forename: Silvana
authors.initials: S
authors.lastname: Guerriero
authors.forename: Lucia
authors.initials: L
authors.lastname: Lapenna
authors.forename: Angelo
authors.initials: A
authors.lastname: Saracino
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Saliani
authors.forename: Antonio
authors.initials: A
authors.lastname: Capurso
authors.forename: Carlo
authors.initials: C
authors.lastname: Sborgia
authors.forename: Pasquale
authors.initials: P
authors.lastname: Coratelli
mesh_terms: D001781:Blood Component Removal; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D009900:Optic Nerve / Q000098:blood supply; D018917:Optic Neuropathy, Ischemic / Q000097:blood / Q000628:therapy*; D011241:Prednisone / Q000627:therapeutic use; D012459:Salicylates / Q000627:therapeutic use; D019821:Simvastatin / Q000627:therapeutic use; D014792:Visual Acuity
chemical_list: D008078:Cholesterol, LDL; D012459:Salicylates; D005340:Fibrinogen; D019821:Simvastatin; D011241:Prednisone