title: Activation of adenosine receptors in the posterior cingulate cortex impairs memory retrieval in the rat.
abstract: Adenosine A1 and A2A receptor agonists and antagonists have been reported to alter learning and memory. The aim of our study was to investigate the involvement of adenosinergic system in memory retrieval into posterior cingulate cortex (PCC) of Wistar rats. To clarify this question, we tested specifics agonist and antagonists of adenosine A1 and A2A receptors in rats submitted to a one-trial inhibitory avoidance task. The stimulation of adenosine A1 and A2A receptors by CPA and CGS21680, respectively, impaired memory retrieval for inhibitory avoidance task, into PCC. These findings provide behavioral evidence for the role of adenosinergic system in the memory retrieval into PCC.
authors.affiliation: Instituto de Pesquisas Biomédicas, Pontifícia universidade Católica do Rio Grande do Sul, Porto Alegre, Rs, Brazil.graceschenatto@hotmail.com
authors.forename: Grace Schenatto
authors.initials: GS
authors.lastname: Pereira
authors.forename: Janine Inez
authors.initials: JI
authors.lastname: Rossato
authors.forename: João José Freitas
authors.initials: JJ
authors.lastname: Sarkis
authors.forename: Martín
authors.initials: M
authors.lastname: Cammarota
authors.forename: Carla Denise
authors.initials: CD
authors.lastname: Bonan
authors.forename: Iván
authors.initials: I
authors.lastname: Izquierdo
mesh_terms: D000241:Adenosine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D005106:Exploratory Behavior / Q000502:physiology; D006179:Gyrus Cinguli / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D008845:Microinjections; D010627:Phenethylamines / Q000008:administration & dosage; D058913:Purinergic Agonists; D058914:Purinergic Antagonists; D051381:Rats; D017208:Rats, Wistar; D043682:Receptor, Adenosine A1 / Q000187:drug effects / Q000378:metabolism*; D043705:Receptor, Adenosine A2A / Q000187:drug effects / Q000378:metabolism*; D014227:Triazines / Q000008:administration & dosage; D014230:Triazoles / Q000008:administration & dosage; D014970:Xanthines / Q000008:administration & dosage
chemical_list: D010627:Phenethylamines; D058913:Purinergic Agonists; D058914:Purinergic Antagonists; D043682:Receptor, Adenosine A1; D043705:Receptor, Adenosine A2A; D014227:Triazines; D014230:Triazoles; D014970:Xanthines; C097270:ZM 241385; C061282:2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine; C048599:N(6)-cyclopentyladenosine; C051360:1,3-dipropyl-8-cyclopentylxanthine; D000241:Adenosine