Neural correlates of visuo-spatial attention during an antisaccade task in schizophrenia: an ERP study.
The authors investigated the role of visuo-spatial attention in an antisaccade task using event-related potentials (ERPs) in schizophrenia patients compared to healthy controls. ERPs between 80-130 ms (P100) after stimulus onset showed differences between pro- and antisaccades only for controls and can be related to the suppression of irrelevant stimulus features. Between 150-180 ms (N100), a larger amplitude for anti-compared to prosaccades over centroparietal electrodes showed that processes of visuo-spatial attention seem to be engaged in performance of the antisaccade task. Left temporo-occipitally, this activity was only evident in schizophrenia patients, possibly reflecting additional neuronal recruitment in order to perform the antisaccade task successfully.
Tendolkar
Indira
I
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany. i.tendolkar@psy.umcn.nl
Ruhrmann
Stephan
S
Brockhaus-Dumke
Anke
A
Pauli
Monika
M
Mueller
Ralf
R
Pukrop
Ralf
R
Klosterkötter
Joachim
J
D000328:Adult; D001288:Attention / Q000502:physiology*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009474:Neurons / Q000473:pathology*; D012438:Saccades / Q000502:physiology*; D012559:Schizophrenia / Q000473:pathology* / Q000503:physiopathology*; D013028:Space Perception / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*