title: Evaluating associations between 5-HTTLPR polymorphism and Alzheimer's disease for Korean patients.
abstract: There has been growing evidence that the serotonin (5-HT) system is important in the regulation of memory and thus might be associated with Alzheimer's disease (AD), while research results on this issue have been inconsistent. The 5-HT system has also been suggested to be responsible for a significant portion of the behavioural aspects of AD. This study aimed to investigate the associations of the 5-HT transporter gene linked polymorphic region (5-HTTLPR) polymorphism with AD and delusional/aggressive symptoms of AD in Korean samples of 65 patients and 43 controls. The 5-HTTLPR polymorphism was neither associated with AD nor with delusional/aggressive symptoms of AD. It was suggested that phenotypic expression of the 5-HTTLPR polymorphism might be varied according to ethnic differences.
authors.affiliation: Department of Neuropsychiatry, School of Medicine, Busan, and Woosan Medical Foundation, Hyung Ju Hospital, Yangsan, Republic of Korea.
authors.forename: Tae Min
authors.initials: TM
authors.lastname: Ha
authors.forename: Deuk Man
authors.initials: DM
authors.lastname: Cho
authors.forename: Sung Woo
authors.initials: SW
authors.lastname: Park
authors.forename: Myung Jin
authors.initials: MJ
authors.lastname: Joo
authors.forename: Bong Ju
authors.initials: BJ
authors.lastname: Lee
authors.forename: Bo Geum
authors.initials: BG
authors.lastname: Kong
authors.forename: Jae Min
authors.initials: JM
authors.lastname: Kim
authors.forename: Jin Sang
authors.initials: JS
authors.lastname: Yoon
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000368:Aged; D000374:Aggression; D000544:Alzheimer Disease / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D003072:Cognition Disorders / Q000175:diagnosis; D015331:Cohort Studies; D003702:Delusions / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007723:Korea; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins
chemical_list: D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins