[Study on the NIR-Raman spectra and NIR-SERS spectra of amsacrine].
The near infrared surface-enhanced Raman spectra (NIR-SERS) of amsacrine,an anticancer agent, on silver collids were recored with high quality. The NIR-SERS enhancement factor is up to 10(4) magnitude. In comparison with the near infrared Raman (NIR-Raman) spectra of solid amsacrine, more information of vibrational structures of amsacrine molecules at low concentration and almost in its practical application envi ronment, can be given by the NIR-SERS. The enhancement mechanism is associated with the adsorption of acridyl ring and sulfonyl on silver surface.
Tian
H
H
National Center of Biomedical Analysis, Academy of Military Medical Sciences, 100850 Beijing.
Liu
B
B
Song
Z
Z
Shen
S
S
Han
J
J
Fang
Y
Y
D000677:Amsacrine / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry*; D007259:Infrared Rays; D012834:Silver / Q000737:chemistry; D013059:Spectrum Analysis, Raman; D013499:Surface Properties
D000970:Antineoplastic Agents; D000677:Amsacrine; D012834:Silver