title: Neural integrator function in murine CACNA1A mutants.
abstract: Time constants of gaze holding are shortened in rocker and tottering mice, two strains whose cerebellar dysfunction stems from genetic alterations of the P/Q calcium channel. The finding suggests that in mice as in primates, the cerebellum contributes to the function of the neural integrator. Studying CACNA1A mutants may elucidate how cerebellar signals support gaze holding.
authors.affiliation: Department of Neurology, Case Western Reserve University, 11100 Euclid Ave., Cleveland, OH 44106-5040, USA. jss6@case.edu
authors.forename: John S
authors.initials: JS
authors.lastname: Stahl
authors.forename: Robert A
authors.initials: RA
authors.lastname: James
mesh_terms: D000818:Animals; D020864:Calcium Channels, N-Type; D020865:Calcium Channels, P-Type / Q000235:genetics*; D020907:Calcium Channels, Q-Type / Q000235:genetics*; D002524:Cerebellar Ataxia / Q000235:genetics; D002531:Cerebellum / Q000502:physiology / Q000503:physiopathology; D005403:Fixation, Ocular; D051379:Mice; D009154:Mutation; D011323:Primates; D015398:Signal Transduction
chemical_list: D020864:Calcium Channels, N-Type; D020865:Calcium Channels, P-Type; D020907:Calcium Channels, Q-Type