title: Efficacy and tolerance of sodium phosphates oral solution after diet liberalization.
abstract: Bowel cleansing regimens commonly require adherence to liquid diets for 24 to 48 hours before examination, which often leads to poor compliance, reduced cleansing, and ultimately inadequate examinations. The authors investigated the efficacy and tolerability of diet liberalization before bowel cleansing with sodium phosphates oral solution. Two hundred patients were randomized into two treatment groups. One group received the standard light breakfast followed by clear liquids the day before colonoscopy; the second had a normal breakfast followed by a low-residue lunch the day before colonoscopy. Both groups had the same bowel preparation with sodium phosphates oral solution (2 x 45-mL, 7 p.m./6 a.m.). There was no difference in clinical efficacy between the two diet regimens (excellent/good in 93% standard, 95% low-residue). Fewer patients receiving the low-residue diet reported hunger, and more patients receiving the low-residue regimen reported energy to perform usual activities. This study supports offering patients a regular breakfast and a low-residue lunch before bowel cleansing with sodium phosphates oral solution.
authors.affiliation: Medical Affairs Department, C. B. Fleet Company, Inc., Lynchburg, Virginia, USA.
authors.forename: Sherrie R
authors.initials: SR
authors.lastname: Scott
authors.forename: Patricia L
authors.initials: PL
authors.lastname: Raymond
authors.forename: William O
authors.initials: WO
authors.lastname: Thompson
authors.forename: Deborah J B
authors.initials: DJ
authors.lastname: Galt
mesh_terms: D000203:Activities of Daily Living; D000284:Administration, Oral; D000704:Analysis of Variance; D001294:Attitude to Health; D002400:Cathartics / Q000627:therapeutic use*; D003113:Colonoscopy; D004035:Diet Therapy / Q000009:adverse effects / Q000379:methods* / Q000523:psychology; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D006815:Hunger; D016015:Logistic Models; D008297:Male; D008612:Menu Planning; D008875:Middle Aged; D009657:North Carolina; D010710:Phosphates / Q000627:therapeutic use*; D011300:Preoperative Care / Q000009:adverse effects / Q000379:methods* / Q000523:psychology; D011446:Prospective Studies; D016037:Single-Blind Method; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014768:Virginia
chemical_list: D002400:Cathartics; D010710:Phosphates; C018279:sodium phosphate