Hepatitis B & hepatitis C in HIV-infection.
Human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) are the three most common chronic viral infections seen in the world. All three viruses share modes of transmission and hence co-exist in the same host at significantly high rates. HIV-induced immunosuppression has deleterious effects on the natural history, pathophysiology, diagnosis, therapeutic responses to hepatitis viruses. Responses to HBV vaccination are impaired in persons with HIV infection. Co-infection with the hepatitis viruses and HIV is likely to become a major health care catastrophe in the coming years. This review discusses the current trends in the understanding of the biology of co-infection and implications for treating these viruses effectively.
Kottilil
Shyam
S
Laboratory of Immunoregulation, National Institute of Allergy & Infectious Diseases, National Institutes of Health, Building 10, Rm. 11N204, 9000 Wisconsin Avenue, Bethesda, MD 20892, USA. Skottilil@niaid.nih.gov
Jackson
Julia O
JO
Polis
Michael A
MA
D000998:Antiviral Agents / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications*; D006509:Hepatitis B / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology; D017325:Hepatitis B Vaccines / Q000008:administration & dosage; D006526:Hepatitis C / Q000150:complications* / Q000503:physiopathology; D006801:Humans
D000998:Antiviral Agents; D017325:Hepatitis B Vaccines