title: Pressure and temperature stability of 5-methyltetrahydrofolic acid: a kinetic study.
abstract: Detailed kinetic studies of [6S] and [6RS] 5-methyltetrahydrofolic acid (5-CH3-H4folate) degradation during thermal (from 60 to 90 degrees C) and high pressure/thermal (from 30 to 45 degrees C; from 200 to 700 MPa) treatments were carried out. The results confirmed that the temperature and pressure induced degradation kinetics of [6S] 5-CH3-H4folate were identical (within 95% confidence interval) with those of [6RS] 5-CH3-H4folate. Under equal processing conditions, the estimated degradation rate constants (k), activation energy (E(a)), and activation volume (V(a)) values of [6S] and [6RS] 5-CH3-H4folate were the same (95% confidence interval). The modified thermodynamic model proposed by Nguyen and co-workers (J. Agric. Food Chem. 2003, 51, 3352-3357) to describe the pressure and temperature dependence of the rate constant for folate degradation was reevaluated.
authors.affiliation: Faculty of Applied Bioscience and Engineering, Department of Food and Microbial Technology, Laboratory of Food Technology, Katholieke Universiteit Leuven, Kasteelpark Arenberg 22, B-3001 Leuven, Belgium.
authors.forename: Indrawati
authors.initials: I
authors.lastname: Indrawati
authors.forename: Ann
authors.initials: A
authors.lastname: Van Loey
authors.forename: Marc
authors.initials: M
authors.lastname: Hendrickx
mesh_terms: D004355:Drug Stability; D007700:Kinetics; D011312:Pressure; D013696:Temperature; D013763:Tetrahydrofolates / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D013763:Tetrahydrofolates; C005984:5-methyltetrahydrofolate