title: Glutamatergic dysfunction in OCD.
abstract: The role of glutamatergic dysfunction in the pathophysiology of OCD has hardly been explored despite recent reports implicating glutamatergic dysfunction in OCD. We decided to investigate CSF glutamate levels in adult OCD probands compared to psychiatrically normal controls. In total, 21 consenting psychotropic drug-naïve adult OCD patients, diagnosed using SCID-IV-CV, and 18 consenting psychiatrically normal controls with age within 10 years of age of the patients, who did not have any history of head injury or neurological illness, were included into the study. Aseptically collected and stored CSF samples obtained from the patients and control subjects were used for glutamate estimation, which was carried out by a modification of the procedure described by Lund (1986). CSF glutamate (micromol/l) level was found to be significantly higher [F(1,31)=6.846, p=0.014] in OCD patients (47.12+/-4.25) compared to control subjects (41.36+/-3.63) on analysis of covariance. There was no effect of gender, age, duration of illness, Y-BOCS score, or CGI-S score on CSF glutamate levels. Our study provides preliminary evidence implicating glutamatergic excess in the pathophysiology of OCD, which needs to be further explored by studies from other centers involving larger sample sets from different age groups.
authors.affiliation: Department of Molecular Neurobiochemistry, International Graduate School of Neuroscience, Ruhr University Bochum, Bochum, Germany.
authors.forename: Kaushik
authors.initials: K
authors.lastname: Chakrabarty
authors.forename: Sagnik
authors.initials: S
authors.lastname: Bhattacharyya
authors.forename: Rita
authors.initials: R
authors.lastname: Christopher
authors.forename: Sumant
authors.initials: S
authors.lastname: Khanna
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D005260:Female; D018698:Glutamic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000134:cerebrospinal fluid*; D011569:Psychiatric Status Rating Scales; D012737:Sex Factors
chemical_list: D018698:Glutamic Acid