title: Polymeric micelles and nanoparticles from block and statistical poly((RS)-3,3-dimethylmalic acid) derivatives: preparation and characterization.
abstract: Amphiphilic and biodegradable micelles and nanoparticles designed as potential drug carriers were prepared from biodegradable statistical and block copolyesters obtained by a living anionic ring-opening process. These novel materials display amphiphilic properties arising from the joint presence of hydrophilic poly((RS)-3,3-dimethylmalic acid) and hydrophobic poly(hexyl (RS)-3,3-dimethylmalate) segments. Micelles obtained from a well-defined block copolymer have been characterized by their critical aggregation concentration, and nanoparticles derived from statistical copolymer have been analyzed by transmission electron microscopy (TEM).
authors.affiliation: Laboratoire de Recherche sur les Polyméres, UMR C7581 CNRS-Université Paris XII, 2-8 Rue Henri Dunant, F-94320 Thiais, France.
authors.forename: Farid
authors.initials: F
authors.lastname: Ouhib
authors.forename: Solo
authors.initials: S
authors.lastname: Randriamahefa
authors.forename: Véronique
authors.initials: V
authors.lastname: Wintgens
authors.forename: Philippe
authors.initials: P
authors.lastname: Guérin
authors.forename: Christel
authors.initials: C
authors.lastname: Barbaud
mesh_terms: D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D008293:Malates / Q000737:chemistry*; D008823:Micelles; D008854:Microscopy, Electron; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: C505108:3,3-dimethylmalic acid; D004337:Drug Carriers; D008293:Malates; D008823:Micelles; D011108:Polymers