title: Off-pump coronary artery bypass grafting attenuates proinflammatory markers.
abstract: OBJECTIVE
  Cardiac surgery with cardiopulmonary bypass (CPB) has been considered the main causative factors of postoperative inflammatory reactions. The aim of this study was to compare surrogate markers of the proinflammatory response in patients who underwent coronary artery bypass grafting (CABG) with or without CPB.
  
  
  RESULTS
  Twenty patients undergoing first-time CABG were enrolled in the study, 10 with and 10 without CPB. Blood samples were drawn at the following times: at the anesthetic induction, the end of surgery, and thereafter at 12 and 24 hours postoperatively. Neutrophil elastase, interleukin (IL)-6 , and serum soluble Fas were chosen to evaluate the extent of the systemic inflammatory response. The groups were similar in terms of age, gender ratio, number of grafts per patient. There were no operative mortality or serious postoperative complications. Two of each group received blood transfusion postoperatively. Neutrophil elastase showed a significantly higher value in the on-pump group compared with the off-pump group at the end of surgery. Soluble Fas level showed a higher value at the end of surgery compared with baseline, while it had no significant changes in the off-pump patients. IL-6 levels in the on-pump group were consistently higher compared to the off-pump group but showed no statistically significant differences between the groups.
  
  
  CONCLUSIONS
  Compared with off-pump CABG, on pump CABG induced higher serum levels of proinflammatory markers including neutrophil elastase and soluble Fas.
authors.affiliation: Department of Cardiovascular Surgery, Omiya Medical Center, Jichi Medical School, 1-847 Amanuma, Omiya-ku, Saitama 330-8503, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yamaguchi
authors.forename: Hidehito
authors.initials: H
authors.lastname: Endo
authors.forename: Koji
authors.initials: K
authors.lastname: Kawahito
authors.forename: Hideo
authors.initials: H
authors.lastname: Adachi
authors.forename: Takashi
authors.initials: T
authors.lastname: Ino
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000379:methods*; D016022:Case-Control Studies; D015331:Cohort Studies; D001026:Coronary Artery Bypass / Q000009:adverse effects / Q000379:methods*; D003327:Coronary Disease / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011300:Preoperative Care; D011336:Probability; D011379:Prognosis; D018570:Risk Assessment; D016896:Treatment Outcome
chemical_list: D018836:Inflammation Mediators