title: The effect of nabilone on neuropsychological functions related to driving ability: an extended case series.
abstract: The primary goal of this prospective extended case series was to obtain the first data about the potential influence of nabilone intake on driving ability related neuropsychological functions. Six patients were investigated within a placebo controlled, double-blind crossover study of this synthetic cannabinoid (2 mg/day) in patients with multiple sclerosis and spasticity associated pain. Five neuropsychological functions (reaction time, working memory, divided attention, psychomotor speed and mental flexibility) were assessed. No indication was found of a deterioration of any of the five investigated neuropsychological functions during the 4-week treatment period with nabilone.
authors.affiliation: Department of Biological Psychiatry, Innsbruck University Clinics, Austria. ilsemarie.kurzthaler@uibk.ac.at
authors.forename: Ilsemarie
authors.initials: I
authors.lastname: Kurzthaler
authors.forename: Thomas
authors.initials: T
authors.lastname: Bodner
authors.forename: Georg
authors.initials: G
authors.lastname: Kemmler
authors.forename: Tanja
authors.initials: T
authors.lastname: Entner
authors.forename: Joerg
authors.initials: J
authors.lastname: Wissel
authors.forename: Thomas
authors.initials: T
authors.lastname: Berger
authors.forename: W Wolfgang
authors.initials: WW
authors.lastname: Fleischhacker
mesh_terms: D000328:Adult; D000368:Aged; D000932:Antiemetics / Q000009:adverse effects* / Q000627:therapeutic use; D001288:Attention / Q000187:drug effects; D001334:Automobile Driving; D018592:Cross-Over Studies; D004311:Double-Blind Method; D013759:Dronabinol / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000523:psychology; D009128:Muscle Spasticity / Q000150:complications / Q000188:drug therapy / Q000523:psychology; D010146:Pain / Q000209:etiology; D011446:Prospective Studies; D011597:Psychomotor Performance / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects
chemical_list: D000932:Antiemetics; C011941:nabilone; D013759:Dronabinol