title: Structural brain changes in bipolar disorder using deformation field morphometry.
abstract: The objective of this study was to investigate anatomical brain abnormalities in adult bipolar patients using a deformation field morphometry technique. Our sample consisted of 32 right-handed bipolar I patients (men/women=16/16) and 32 right-handed, age and gender matched healthy controls. Deformation field morphometry analysis was performed on three-dimensional spoiled gradient recalled acquisition images. We found gender-specific structural differences between bipolar patients and healthy individuals. Bipolar men had significantly larger lateral ventricles (especially pronounced in the left hemisphere) and smaller left dorsolateral prefrontal cortex than healthy male controls. Our results are complementary to the findings of functional imaging and post-mortem studies that demonstrate abnormalities in the dorsolateral prefrontal cortex in bipolar patients.
authors.affiliation: Division of Mood and Anxiety Disorders, South Texas Veterans Health Care System, Audie L. Murphy Division, San Antonio, Texas, USA. soares@uthscsa.edu
authors.forename: Jair C
authors.initials: JC
authors.lastname: Soares
authors.forename: Peter
authors.initials: P
authors.lastname: Kochunov
authors.forename: E Serap
authors.initials: ES
authors.lastname: Monkul
authors.forename: Mark A
authors.initials: MA
authors.lastname: Nicoletti
authors.forename: Paolo
authors.initials: P
authors.lastname: Brambilla
authors.forename: Roberto B
authors.initials: RB
authors.lastname: Sassi
authors.forename: Alan G
authors.initials: AG
authors.lastname: Mallinger
authors.forename: Ellen
authors.initials: E
authors.lastname: Frank
authors.forename: David J
authors.initials: DJ
authors.lastname: Kupfer
authors.forename: Jack
authors.initials: J
authors.lastname: Lancaster
authors.forename: Peter
authors.initials: P
authors.lastname: Fox
mesh_terms: D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000473:pathology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D020547:Lateral Ventricles / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000473:pathology*; D012727:Sex Characteristics