Functionalized foldamers: synthesis and characterization of a glycosylated beta-peptide 314-helix conveying the TN-antigen.
Herein we describe the design, synthesis, and solution structure of a novel type of conjugate composed of a naturally occurring bio-active ligand bound to an artificial peptidomimetic backbone; in this first report on such functionalized foldamers we utilized a beta-peptide as backbone and a GalNAc carbohydrate residue as ligand.
Norgren
Anna S
AS
Department of Chemistry, Organic Chemistry, Uppsala University, Sweden.
Arvidsson
Per I
PI
D015295:Antigens, Tumor-Associated, Carbohydrate / Q000737:chemistry*; D002942:Circular Dichroism; D006031:Glycosylation; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D017434:Protein Structure, Tertiary
D015295:Antigens, Tumor-Associated, Carbohydrate; D010455:Peptides; C040286:Tn antigen