Diversifying vancomycin via chemoenzymatic strategies.
[reaction: see text] The rapid diversification of glycopeptides via glycorandomization reveals that significantly diverse substitutions are tolerated and suggests there may be a synergistic benefit to the construction of mechanistically related natural product core scaffold fusions. This work also further highlights the utility of chemoenzymatic approaches to diversify complex natural product architectures.
Fu
Xun
X
Laboratory for Biosynthetic Chemistry, Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Avenue, Madison, Wisconsin 53705, USA.
Albermann
Christoph
C
Zhang
Changsheng
C
Thorson
Jon S
JS
D020650:Combinatorial Chemistry Techniques; D013293:Enterococcus faecalis / Q000378:metabolism; D016984:Enterococcus faecium / Q000378:metabolism; D005818:Genetic Engineering; D005964:Glucosyltransferases / Q000378:metabolism*; D006020:Glycopeptides / Q000737:chemistry*; D016106:Methicillin Resistance / Q000502:physiology; D015394:Molecular Structure; D012475:Salmonella / Q000378:metabolism; D013211:Staphylococcus aureus / Q000378:metabolism; D014640:Vancomycin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D006020:Glycopeptides; D014640:Vancomycin; D005964:Glucosyltransferases; C430144:glucosyltransferase E