Erythroderma with lichenoid granulomatous features induced by erythropoietin.
The increasing use of new drugs in cancer therapy, especially growth factors, hormones, and chemotherapies resulted in several reports of unusual skin eruptions. We studied a patient with erythroderma who had received erythropoietin because of myeloma with tumor anemia. The histological features were characterized by a lichenoid, focally granulomatous infiltrate with predominance of histiocytes. It is important for dermatopathologists to recognize this interesting pattern induced by erythropoietin.
Wolf
Ingrid H
IH
Department of Dermatology, University of Graz, Graz, Austria. ingrid.wolf@meduni-graz.at
Smolle
J
J
Cerroni
L
L
Kerl
H
H
D000740:Anemia / Q000188:drug therapy / Q000209:etiology; D015703:Antigens, CD / Q000378:metabolism; D003873:Dermatitis, Exfoliative / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology*; D004921:Erythropoietin / Q000009:adverse effects* / Q000627:therapeutic use; D006099:Granuloma / Q000473:pathology*; D006644:Histiocytes / Q000378:metabolism / Q000473:pathology; D006801:Humans; D017512:Lichenoid Eruptions / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications; D013601:T-Lymphocytes / Q000378:metabolism / Q000473:pathology
D015703:Antigens, CD; D004921:Erythropoietin