title: The World Trade Center residents' respiratory health study: new-onset respiratory symptoms and pulmonary function.
abstract: The destruction of the World Trade Center (WTC) on 11 September 2001 in New York City resulted in the massive release of pulverized dust and combustion products. The dust and smoke settled in the surrounding area, which encompassed a large residential community. We hypothesized that previously normal residents in the community surrounding the former WTC would have an increased incidence of persistent respiratory symptoms and abnormalities in screening spirometry. A hybrid cross-sectional and retrospective cohort study using a symptom-based questionnaire and onsite screening spirometry in residents in an exposed area and in a control area was performed 12 +/- 4 months after the collapse. Surveys were analyzed from 2,812 residents. New-onset respiratory symptoms were described by 55.8% of residents in the exposed area, compared with 20.1% in the control area after the event. Persistent new-onset symptoms were identified in 26.4 versus 7.5% of residents in the exposed area versus control area, respectively. No differences in screening spirometry between the groups were detected. A small pilot study suggested the possibility of an increase in bronchial hyperresponsiveness in exposed participants with persistent symptoms. The data demonstrate an increased rate of new-onset and persistent respiratory health effects in residents near the former WTC compared with a control population.
authors.affiliation: Department of Medicine, Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, New York, New York 10016, USA. reibmj01@gcrc.med.nyu.edu
authors.forename: Joan
authors.initials: J
authors.lastname: Reibman
authors.forename: Shao
authors.initials: S
authors.lastname: Lin
authors.forename: Syni-An A
authors.initials: SA
authors.lastname: Hwang
authors.forename: Mridu
authors.initials: M
authors.lastname: Gulati
authors.forename: James A
authors.initials: JA
authors.lastname: Bowers
authors.forename: Linda
authors.initials: L
authors.lastname: Rogers
authors.forename: Kenneth I
authors.initials: KI
authors.lastname: Berger
authors.forename: Anne
authors.initials: A
authors.lastname: Hoerning
authors.forename: Marta
authors.initials: M
authors.lastname: Gomez
authors.forename: Edward F
authors.initials: EF
authors.lastname: Fitzgerald
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000393:Air Pollutants / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003252:Construction Materials; D003371:Cough / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004391:Dust; D004417:Dyspnea / Q000453:epidemiology; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009519:New York City / Q000453:epidemiology; D012111:Residence Characteristics; D012135:Respiratory Sounds; D047851:September 11 Terrorist Attacks; D013147:Spirometry
chemical_list: D000393:Air Pollutants; D004391:Dust