DNA methylation, nucleosome formation and positioning.
Recent mapping of nucleosome positioning on several long gene regions subject to DNA methylation has identified instances of nucleosome repositioning by this base modification. The evidence for an effect of CpG methylation on nucleosome formation and positioning in chromatin is reviewed here in the context of the complex sequence-structure requirements of DNA wrapping around the histone octamer and the role of this epigenetic mark in gene repression.
Pennings
Sari
S
Molecular Physiology Group, University of Edinburgh Medical School, Wilkie Building, Edinburgh EH8 9AG, UK. Sari.Pennings@ed.ac.uk
Allan
James
J
Davey
Colin S
CS
D000818:Animals; D002843:Chromatin / Q000378:metabolism; D018899:CpG Islands; D004247:DNA / Q000378:metabolism; D019175:DNA Methylation; D015972:Gene Expression Regulation, Neoplastic; D006657:Histones / Q000378:metabolism; D006801:Humans; D046911:Macromolecular Substances / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism*; D009707:Nucleosomes / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D011485:Protein Binding
D002843:Chromatin; D006657:Histones; D046911:Macromolecular Substances; D009707:Nucleosomes; D004247:DNA