[Genotoxic and radioprotective properties of 2,5-diphenyloxazole and its derivatives on mice DNA structure in vivo].
The effects of 2,5-diphenyloxazole ad its derivatives suggested as nontraditional radioprotectors on mice spleen DNA structure were studied. The effects of these compounds were studied on intraperitoneal injection with and without subsequent X-ray exposure of mice to a dose of 12 cGy. The formation of double-strand breaks and DNA conformation change (by adsorption on NC filters) were recorded. A genotoxic effect of 2,5-diphenyloxazole and its derivatives, a nonlinearity of their dose-response relationships and different effects depending on the substance concentration were found. Some of the compounds exhibited radioprotective properties in certain concentration.
Zhizhina
G P
GP
Zavarykina
T M
TM
Burlakova
E B
EB
Noskov
V G
VG
Dukhovich
F S
FS
D000818:Animals; D004247:DNA / Q000032:analysis / Q000187:drug effects / Q000528:radiation effects*; D004249:DNA Damage; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D009153:Mutagens / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity*; D009690:Nucleic Acid Conformation / Q000187:drug effects / Q000528:radiation effects; D010080:Oxazoles / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D011837:Radiation-Protective Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D013154:Spleen / Q000737:chemistry / Q000528:radiation effects
D009153:Mutagens; D010080:Oxazoles; D011837:Radiation-Protective Agents; D004247:DNA; C009012:2,5-diphenyloxazole