title: Changes in central venous pressure with vasoactive drug injections in humans.
abstract: We tested whether central venous pressure (CVP) changes during vasoactive drug injections used for baroreflex assessment in humans. We measured CVP during sequential intravenous boluses of nitroprusside (NTP) and phenylephrine (PHE; modified Oxford technique). NTP caused a decrease in CVP of 1.9+/-0.2 mmHg from baseline (P<0.01) and PHE caused an increase in CVP of 0.3+/-0.2 mmHg above baseline. These changes in CVP may contribute to the observed integrated baroreflex responses.
authors.affiliation: Dept. of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Rochester (MN) 55905, USA.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Martin
authors.forename: Nisha
authors.initials: N
authors.lastname: Charkoudian
mesh_terms: D000328:Adult; D017704:Baroreflex / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002496:Central Venous Pressure / Q000187:drug effects*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007267:Injections; D008297:Male; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology; D009599:Nitroprusside / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D010991:Plethysmography; D012039:Regional Blood Flow / Q000502:physiology; D012189:Retrospective Studies; D013564:Sympathetic Nervous System / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D009599:Nitroprusside; D010656:Phenylephrine