Influences of apolipoprotein E polymorphism on the risk for breast cancer and HER2/neu status in Taiwan.
Apolipoprotein E (APOE) polymorphism plays an important role in lipid metabolism. Preliminary evidence suggests that APOE genotype appears to be a risk factor for not only cardiovascular disease, but also Alzheimer's disease and cancer. We screened the APOE genotype in 290 breast cancer patients and 232 non-cancer controls and determined the relationship between APOE gene polymorphism and breast cancer in Taiwan. We found risk for breast cancer was associated with the APOE genotype (xi(2) = 8.652, p = 0.013). Carriers of the epsilon4 allele were more common in breast cancer cases than carriers of epsilon3 allele (p = 0.004, OR = 1.786, 95% CI: 1.197-2.664). In addition, the epsilon4 allele is also associated with HER2/neu negative status in breast cancer patients (p = 0.006, OR = 0.277, 95% CI: 0.111-0.693). No significant associations between APOE genotype and tumor grade, TN classification, progesterone receptor, estrogen receptor, lymphatic invasion, or recurrence of breast cancer were in evidence. These results suggest that the APOE epsilon4 allele may be a risk factor for breast cancer and correlates with HER2/neu negative status.
Chang
Nai-Wen
NW
Department of Biochemistry, College of Medicine, China Medical University, 91 Hsueh-Shih Road, Taichung 404, Taiwan. nwchang@mail.cmu.edu.tw
Chen
Dar-Ren
DR
Wu
Chen-Ten
CT
Aouizerat
Bradley E
BE
Chen
Fei-Na
FN
Hung
Shin-Jer
SJ
Wang
Shiuan-Huei
SH
Wei
Ming-Feng
MF
Chang
Cheng-Shyong
CS
D000328:Adult; D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D050356:Lipid Metabolism; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics*; D011960:Receptors, Estrogen / Q000032:analysis; D012307:Risk Factors; D013624:Taiwan
D001057:Apolipoproteins E; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen