[Relationship of serum level of creatine kinase of MB type to cardiac function of patients with advanced tumors and its prognostic value].
OBJECTIVE
Patients with advanced tumors usually suffer from cardiac dysfunction. Monitoring cardiac function is important for these patients. Serum creatine kinase of MB type (CK-MB) is a biochemical marker of cardiac damage. This study was to estimate relationship of serum level of CK-MB to cardiac function of patients with advanced tumors, and its prognostic value.


METHODS
Serum CK-MB in 68 patients with advanced tumors was detected by immunoinhibition assay. Observation group was composed of 34 patients with elevated serum CK-MB. Control group was composed of 34 patients with normal serum CK-MB level.


RESULTS
Incidence of cardiac insufficiency of grade III-IV was significantly higher in observation group than in control group (21 vs. 6, P < 0.05). Mortality of observation group was significantly higher than that of control group (25 vs. 8, P < 0.01). Elevation of serum CK-MB was frequently found in patients with primary liver cancer or liver metastasis (P < 0.05).


CONCLUSIONS
Patients with elevated serum CK-MB often suffer from cardiac insufficiency, severe illness status, and have high mortality. Serum level of CK-MB may be a predictor of poor prognosis of patients with advanced tumors.
Wu
Xiao-Ming
XM
Polyclinic Department, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, P. R. China. wangmr@263.net.cn
Hu
Cheng-Zhang
CZ
Li
Ning
N
Zhu
Ji-Qing
JQ
Wu
Yan-Fang
YF
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000097:blood / Q000503:physiopathology; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000503:physiopathology; D052279:Creatine Kinase, MB Form / Q000097:blood*; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006334:Heart Function Tests; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000503:physiopathology; D008175:Lung Neoplasms / Q000097:blood / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009369:Neoplasms / Q000097:blood* / Q000503:physiopathology; D011379:Prognosis
D052279:Creatine Kinase, MB Form