[The effect of antiepileptic drug therapy on cognitive evoked potentials and reaction time].
It is well known that antiepileptic drugs have side effects on cognitive and behavioral functioning of the treated patients.


OBJECTIVE
Our goal was to investigate their effect on cognitive evoked potential peak latencies and patient reaction times to target stimuli for two different, acoustic and visual stimulating paradigms. Therefore, a control group of healthy subjects and three groups of patients treated with antiepileptic drugs (carbamazepine, phenobarbital) were compared.


METHODS
Group 1 of 19 epileptic patients had undertherapeutic and group 2 of 16 patients had a therapeutic concentration of these drugs. Group 3 of 18 patients were treated with carbamazepine in therapeutic dose for nonepileptic reasons. The N1, P2, N2, P3a and P3b peak latencies as well as reaction time to the same target stimuli were analyzed.


CONCLUSIONS
Obtained for acoustic and visual stimulating paradigm in the control group showed no significant differences results suggesting it to be sufficient to use simple acoustic paradigm for screening. The hypothesis that antiepileptic drugs influence the parameters of cognitive evoked potentials when used as polytherapy was confirmed. The reaction time measured in the same groups showed statistically significant differences between healthy subjects and drug treated patients. The effect of antiepileptic drugs on peak latencies of cognitive evoked potentials was statistically significant, and an even greater effect was recorded on the reaction time of treated patients.


CONCLUSIONS
The results obtained in the study were in accordance with our hypothesis that this neurophysiological method could be successfully used as a screening method to check the cognitive and motor state of antiepileptic medication.
Nesek-Madarić
Vesna
V
Klinika za neurologiju, Klinicki bolnicki centar Zagreb, Zagreb, Hrvatska.
Isgum
Velimir
V
D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000494:pharmacology*; D004827:Epilepsy / Q000188:drug therapy / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011930:Reaction Time / Q000187:drug effects*
D000927:Anticonvulsants