title: [Optimization of antibacterial therapy in operated neonates on the basis of early diagnosis of septic complications].
abstract: The paper is based on the results obtained during examination and intensive care in 175 neonatal infants operated on for various malformations who were treated in the pediatric intensive care unit, Moscow Regional Research Institute of Clinical Studies, in 1998 to 2000. Analyzing the results has indicated that 24% of the patients have signs of early sepsis just within the first 24 postoperative hours. The marker procalcitonin was determined in 75 neonatal infants. The studies performed lead to the conclusion that procalcitonin is a highly sensitive and specific marker of sepsis by which postoperative septic complications can be diagnosed in the early periods. The early diagnosis of sepsis, by using the marker procalcitonin permitted timely rational correction of antibiotic therapy, which improved the basic parameters of treatment and reduced deaths from septic complications from 48 to 36%.
authors.forename: E M
authors.initials: EM
authors.lastname: Buzurnaia
authors.forename: E V
authors.initials: EV
authors.lastname: Mel'nikova
authors.forename: V M
authors.initials: VM
authors.lastname: Iurevich
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D001772:Blood Cell Count; D002116:Calcitonin / Q000097:blood; D015740:Calcitonin Gene-Related Peptide; D000013:Congenital Abnormalities / Q000601:surgery*; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D011183:Postoperative Complications; D011498:Protein Precursors / Q000097:blood; D012189:Retrospective Studies; D012307:Risk Factors; D018805:Sepsis / Q000097:blood* / Q000188:drug therapy / Q000209:etiology / Q000401:mortality; D012720:Severity of Illness Index
chemical_list: D000900:Anti-Bacterial Agents; D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide