Expanding diversity in dynamic combinatorial libraries: simultaneous exchange of disulfide and thioester linkages.
Dynamic combinatorial libraries have been prepared which feature two simultaneous covalent exchange reactions in aqueous solution at neutral pH. This allows for diversity, not only of the subunits that are linked, but also of the linkage itself.
Leclaire
Julien
J
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
Vial
Laurent
L
Otto
Sijbren
S
Sanders
Jeremy K M
JK
D002851:Chromatography, High Pressure Liquid; D020650:Combinatorial Chemistry Techniques; D016208:Databases, Factual; D004220:Disulfides / Q000737:chemistry*; D004952:Esters / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D012996:Solutions; D013438:Sulfhydryl Compounds / Q000737:chemistry*
D004220:Disulfides; D004952:Esters; D012996:Solutions; D013438:Sulfhydryl Compounds