Placental diagnostic criteria and clinical correlation--a workshop report.
Placental pathology is a valuable link explaining how underlying pregnancy risk factors result in adverse pregnancy outcome. This potentially useful information is currently underutilized due to a general lack of rigor in placental diagnosis. This lack of rigor is in large part due to a failure to appreciate the importance of the information provided and hence to demand accurate and clinically responsive reporting. This workshop reviewed the results of a recent initiative by the Perinatal Section of the Society for Pediatric Pathology to systematize and validate diagnostic schema for the description of lesions related to three important pathologic processes: amniotic fluid infection, maternal vascular underperfusion, and fetal vascular obstruction. This was followed by presentation of three studies correlating these pathologic processes with the following clinical outcomes: complications of prematurity, fetal growth restriction, and neurodisability following term delivery.
Redline
R W
RW
Department of Pathology, Case School of Medicine, Cleveland, OH 44106, USA. raymond.redline@uhhs.com
Heller
D
D
Keating
S
S
Kingdom
J
J
D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D010920:Placenta / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000473:pathology; D011256:Pregnancy Outcome; D014463:Ultrasonography