[Roles of PPARs in carcinogenesis].
Peroxisome proliferator activated receptors (PPARs) is known to be expressed in several cancers, but their roles on carcinogenesis has not been confirmed. PPARalpha and delta have not been defined whether as an accelerator or an inhibitor, but now PPARgamma is thought as an inhibitor on carcinogenesis. Therefore, we attempted to elucidate the role of PPARgamma in gastric carcinogenesis and explore the possibility of using PPARgamma ligand as chemopreventive agent for gastric cancer with PPARgamma knockout mice. The present study demonstrated that PPARgamma suppresses gastric carcinogenesis, the PPARgamma ligand troglitazone is a potential chemopreventive agent for gastric carcinogenesis, and troglitazone's chemopreventive effect is dependent on PPARgamma. Unfortunately, thiazolidinediones such as troglitazone has side effects, including edema at the high dose of administration. So we expect the development of new PPARgamma ligands, which are more selective and powerful for PPARgamma, to break through the difficulties of PPARgamma ligands' use clinically.
Imamura
Kazuhiro
K
Department of Gastrointestinal Surgery, Surgical Science, Graduate School of Medicine, The University of Tokyo.
Lu
Jie
J
Kaminishi
Michio
M
D000818:Animals; D008024:Ligands; D051379:Mice; D009369:Neoplasms / Q000209:etiology*; D009374:Neoplasms, Experimental; D047492:Peroxisome Proliferator-Activated Receptors / Q000502:physiology*
D008024:Ligands; D047492:Peroxisome Proliferator-Activated Receptors