[Effect of gestrinone on the lipid metabolic parameters and bone mineral density in patients with endometriosis].
OBJECTIVE
To observe the change of lipid metabolic parameters, sex hormone and bone mineral density (BMD) in patients with endometriosis before and after oral administration of gestrinone.


METHODS
Fifty-six patients with endometriosis, aged from 20 to 45, were treated with gestrinone 2.5 mg two times a week for 6 months one week after operation. Serum total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), ApoA(1), ApoB, follicle stimulating hormone (FSH), luteinizing hormone (LH), E(2) and BMD were determined before taking gestrinone, after taking for 6 months and withdrawal for 6 months.


RESULTS
After administration of gestrinone for 6 months, serum HDL-C and ApoA(1) decreased significantly (P < 0.05). Serum LDL-C and ApoB increased significantly (P < 0.05). Serum E(2) and BMD decreased evidently. Serum TG, TC, FSH and LH were not changed evidently. After withdrawal of gestrinone for 6 months, serum parameters restored to levels before taking gestrinone except BMD.


CONCLUSIONS
Gestrinone can decrease serum E(2) and BMD in patients with endometriosis, which may not be good for lipid metabolism. It is not advisable to take gestrinone for long term.
Zheng
Ping
P
Department of Gynecology, Beijing Obstetrics and Gynecology Hospital, Capital University of Medical Science, China.
Zhang
Yu-fang
YF
Wang
Jian-dong
JD
D000328:Adult; D015519:Bone Density / Q000187:drug effects*; D004715:Endometriosis / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005867:Gestrinone / Q000008:administration & dosage*; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult
D008055:Lipids; D005867:Gestrinone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone