title: Central hypothyroidism in infants who were born to mothers with thyrotoxicosis before 32 weeks' gestation: 3 cases.
abstract: We describe 3 infants who were born to mothers with Graves' disease and developed central hypothyroidism that persisted for >6 months after birth. Two were preterm infants, and the other was a term infant who was born to a euthyroid mother who had been treated with an antithyroid drug since week 31 of gestation. These cases suggest that passage of thyroid hormones can occur from a thyrotoxic mother to the fetus and that the gestational period earlier than 32 weeks may be the critical time for development of central hypothyroidism.
authors.affiliation: Department of Perinatal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama City 641-0012, Japan. rhiguchi@wakayama-med.ac.jp
authors.forename: Ryuzo
authors.initials: R
authors.lastname: Higuchi
authors.forename: Masakazu
authors.initials: M
authors.lastname: Miyawaki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kumagai
authors.forename: Takahiro
authors.initials: T
authors.lastname: Okutani
authors.forename: Yuko
authors.initials: Y
authors.lastname: Shima
authors.forename: Megumi
authors.initials: M
authors.lastname: Yoshiyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ban
authors.forename: Norisige
authors.initials: N
authors.lastname: Yoshikawa
mesh_terms: D005260:Female; D006111:Graves Disease / Q000150:complications*; D006801:Humans; D007037:Hypothyroidism / Q000209:etiology*; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000209:etiology*; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications; D013971:Thyrotoxicosis / Q000150:complications*; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine / Q000097:blood
chemical_list: D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D013974:Thyroxine