title: Ketogenic diet prevents clusterin accumulation induced by kainic acid in the hippocampus of male ICR mice.
abstract: We investigated the effect of ketogenic diet (KD) on clusterin accumulation in the kainic acid (KA)-induced seizure model. Two days after KA administration, strong clusterin-like immunoreactivity (IR) was detected in the hippocampus in the normal diet (ND)-fed mice. But in the KD-fed mice, few clusterin-like IR was detected. These results indicate that KD has neuroprotective effects throughout diminishing nuclear clusterin accumulation that is involved in caspase-3 independent cell death mechanism.
authors.affiliation: Department of Anatomy and Neurobiology, Institute of Health Science, College of Medicine, Gyeongsang National University, Chinju, Kyungnam 660-751, South Korea.
authors.forename: Hae Sook
authors.initials: HS
authors.lastname: Noh
authors.forename: Dong Wook
authors.initials: DW
authors.lastname: Kim
authors.forename: Sang Soo
authors.initials: SS
authors.lastname: Kang
authors.forename: Gyeong Jae
authors.initials: GJ
authors.lastname: Cho
authors.forename: Wan Sung
authors.initials: WS
authors.lastname: Choi
mesh_terms: D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D016923:Cell Death / Q000502:physiology; D051152:Clusterin; D004040:Dietary Carbohydrates / Q000378:metabolism; D004041:Dietary Fats / Q000378:metabolism; D004195:Disease Models, Animal; D006023:Glycoproteins / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism*; D007608:Kainic Acid; D007657:Ketone Bodies / Q000378:metabolism; D007662:Ketosis / Q000378:metabolism*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D018832:Molecular Chaperones / Q000378:metabolism*; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism*
chemical_list: C495243:Clu protein, mouse; D051152:Clusterin; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D006023:Glycoproteins; D007657:Ketone Bodies; D018832:Molecular Chaperones; D007608:Kainic Acid