Role of CD8+ T lymphocytes in control of Mycobacterium tuberculosis infection.
Tuberculosis remains a global health concern. Control of infection is dependent on cell-mediated immune responses, with CD4+ T lymphocytes playing a central role. In this article, data supporting the importance of CD8+ T lymphocytes is reviewed, with an emphasis on the unique functional roles that this lymphocyte subset may play.
Grotzke
Jeff E
JE
Department of Molecular Microbiology and Immunology, Oregon Health and Science University 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.
Lewinsohn
David M
DM
D000818:Animals; D017951:Antigen Presentation; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D007157:Immunologic Surveillance; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000276:immunology / Q000472:pathogenicity*; D014376:Tuberculosis / Q000276:immunology / Q000517:prevention & control*