[Effects of ethanol extracts from Triptergium wilfordii hook and Stephania tetrandra S. Moore on lymphocytes and cyclooxygenase].
OBJECTIVE
To explore the effects of extracts from Triptergium wilfordii Hook and Stephania tetrandra S. Moore on lymphocytes and cyclooxygenase.


METHODS
Change in proliferation of mice thymic lymphocytes and spleen lymphocytes, contents of 6-keto-PGF1alpha in bovine arterial endothelial cells, PGE2 in murine macrophages were determined.


RESULTS
Proliferation of mice thymic lymphocytes and spleen lymphocytes were inhibited by alcoholic extracts from Triptergium wilfordii Hook, Stephania tertrandra S. Moore. COX-1 and COX-2 were inhibited to different extent by ethanol extracts from Triptergium wilfordii Hook. COX-1 was inhibited by ethanol extracts from Stephania tetrandra S. Moore.


CONCLUSIONS
Part of anti-rheumatic mechanism of the two herbs might probably be mediating through inhibition of lymphocyte proliferation, COX-1 and COX-2.
Long
Qicai
Q
Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou.
Qiu
Jianbo
J
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D002417:Cattle; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry; D031609:Stephania tetrandra / Q000737:chemistry*; D029757:Tripterygium / Q000737:chemistry*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D004365:Drugs, Chinese Herbal