title: New pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective PDE5 inhibitors.
abstract: A series of potent PDE5 inhibitors with high selectivity versus PDE6 isoenzymes was identified.
authors.affiliation: Almirall Prodesfarma Research Center, Cardener 68-74, 08024 Barcelona, Spain.
authors.forename: Joan
authors.initials: J
authors.lastname: Feixas
authors.forename: Maria Paola
authors.initials: MP
authors.lastname: Giovannoni
authors.forename: Claudia
authors.initials: C
authors.lastname: Vergelli
authors.forename: Amadeu
authors.initials: A
authors.lastname: Gavaldà
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Cesari
authors.forename: Alessia
authors.initials: A
authors.lastname: Graziano
authors.forename: Vittorio
authors.initials: V
authors.lastname: Dal Piaz
mesh_terms: D015106:3',5'-Cyclic-GMP Phosphodiesterases; D000818:Animals; D001792:Blood Platelets / Q000201:enzymology; D002417:Cattle; D054706:Cyclic Nucleotide Phosphodiesterases, Type 5; D054707:Cyclic Nucleotide Phosphodiesterases, Type 6; D015394:Molecular Structure; D010726:Phosphodiesterase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D010727:Phosphoric Diester Hydrolases / Q000097:blood / Q000378:metabolism*; D011720:Pyrazoles / Q000138:chemical synthesis / Q000494:pharmacology; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D012160:Retina / Q000201:enzymology; D012680:Sensitivity and Specificity; D013329:Structure-Activity Relationship
chemical_list: D010726:Phosphodiesterase Inhibitors; D011720:Pyrazoles; D011724:Pyridazines; D010727:Phosphoric Diester Hydrolases; D015106:3',5'-Cyclic-GMP Phosphodiesterases; D054706:Cyclic Nucleotide Phosphodiesterases, Type 5; D054707:Cyclic Nucleotide Phosphodiesterases, Type 6