title: Brain-derived neurotrophic factor gene polymorphisms in Japanese patients with sporadic Alzheimer's disease, Parkinson's disease, and multiple system atrophy.
abstract: We studied two genetic polymorphisms (240C/T and 480G/A) of the brain-derived neurotrophic factor (BDNF) gene in Japanese patients with Alzheimer's disease (AD, n = 172), Parkinson's disease (PD, n = 327), and multiple system atrophy (MSA, n = 122), as well as controls (n = 275). The distribution of the 240 C/T polymorphism was significantly different between AD patients and controls, whereas there was no difference in the genotype of the two polymorphisms between MSA and controls or between PD and controls. Our data suggest that BDNF might play a role in AD.
authors.affiliation: Clinical Research Center, Konan Hospital, Shiga, Japan. ma-nishi@vmail.plala.or.jp
authors.forename: Masataka
authors.initials: M
authors.lastname: Nishimura
authors.forename: Sadako
authors.initials: S
authors.lastname: Kuno
authors.forename: Ryuji
authors.initials: R
authors.lastname: Kaji
authors.forename: Hideshi
authors.initials: H
authors.lastname: Kawakami
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D003545:Cysteine / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan / Q000208:ethnology; D008297:Male; D008715:Methionine / Q000235:genetics; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic; D013912:Threonine / Q000235:genetics; D014633:Valine / Q000235:genetics
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D013912:Threonine; D008715:Methionine; D014633:Valine; D003545:Cysteine