Neurotrophins: a ticket to ride for BDNF.
The secretion of BDNF from neurons is under activity-dependent control: this is crucial for the formation of appropriate synaptic connections during development and for learning and memory in adults. New evidence shows that interaction between a motif in the tertiary structure of BDNF and the sorting receptor carboxypeptidase E directs this neurotrophin to the regulated secretory pathway.
Thomas
Kerrie
K
Cardiff University, School of Biosciences, Cardiff, UK.
Davies
Alun
A
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism* / Q000502:physiology*; D043423:Carboxypeptidase H / Q000378:metabolism*; D006801:Humans; D017774:Long-Term Potentiation / Q000502:physiology*; D051379:Mice; D009474:Neurons / Q000378:metabolism*; D014176:Protein Biosynthesis / Q000502:physiology; D021381:Protein Transport / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013569:Synapses / Q000502:physiology*
D019208:Brain-Derived Neurotrophic Factor; D043423:Carboxypeptidase H