[A study of vascular factor in the pathogenesis of polymyositis].
OBJECTIVE
To study ICAM-1, IL-1alpha expression in capillaries and to explore whether capillaries play a role in the pathogenesis of polymyositis.


METHODS
Ten cases of patients with polymyositis and 6 patients with other myopathies were collected. CD34, ICAM-1 and IL-1alpha were selected for a quantitative measurement using an image analysis system, and results were presented as the percent of positive staining in the tissue area.


RESULTS
We found that the percent of capillaries in tissues from polymyositis was significantly less than that from controls (P = 0.009). ICAM-1 and IL-1alpha expression in endothelial cells of capillaries were stronger in polymyositis patients.


CONCLUSIONS
Our findings indicated that changes of capillaries might participate in the pathogenesis of polymyositis.
Wang
Min
M
Department of Neurology, Xuanwu Hospitol, Capital University of Medical Sciences, Beijing 100053, China.
Jia
Jian-ping
JP
Da
Yu-wei
YW
D000293:Adolescent; D000328:Adult; D018952:Antigens, CD34 / Q000032:analysis; D002196:Capillaries / Q000378:metabolism / Q000473:pathology; D002648:Child; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis; D007375:Interleukin-1 / Q000032:analysis; D008875:Middle Aged; D017285:Polymyositis / Q000209:etiology / Q000378:metabolism* / Q000473:pathology
D018952:Antigens, CD34; D007375:Interleukin-1; D018799:Intercellular Adhesion Molecule-1