title: Increased intratumoral expression of prostate secretory protein of 94 amino acids predicts for worse disease recurrence and progression after radical prostatectomy in patients with prostate cancer.
abstract: OBJECTIVE
  To examine the impact of prostate secretory protein of 94 amino acids (PSP94) expression within the primary tumor on disease recurrence and progression using radical prostatectomy specimens from patients with adenocarcinoma of the prostate.
  
  
  METHODS
  PSP94 immunohistochemistry was performed on 59 radical prostatectomy specimens. The degree of PSP94 expression was reported as either present (group 1) or absent (group 2). Clinical data, including survival outcome measures, were correlated with PSP94 expression.
  
  
  RESULTS
  The time to disease progression for group 1 was shorter compared with that for group 2 (P = 0.042). Disease-free survival was also less in group 1 than in group 2 (P = 0.033). Multivariate analyses demonstrated that PSP94 expression was an independent prognostic factor for a shorter interval to disease progression (P = 0.046) and disease-free survival (P = 0.049).
  
  
  CONCLUSIONS
  PSP94 expression in radical prostatectomy tumor specimens appears to be associated with worsened survival outcomes and may provide additional prognostic information.
authors.affiliation: Department of Surgery, Division of Urology, Clinical Cancer Research Program, The London Regional Cancer Centre, London, Ontario, Canada.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Girvan
authors.forename: Peter
authors.initials: P
authors.lastname: Chang
authors.forename: Isaac
authors.initials: I
authors.lastname: van Huizen
authors.forename: Madeleine
authors.initials: M
authors.lastname: Moussa
authors.forename: Jim W
authors.initials: JW
authors.lastname: Xuan
authors.forename: Larry
authors.initials: L
authors.lastname: Stitt
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Chin
authors.forename: Yasuto
authors.initials: Y
authors.lastname: Yamasaki
authors.forename: Jonathan I
authors.initials: JI
authors.lastname: Izawa
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000378:metabolism* / Q000601:surgery*; D000368:Aged; D018450:Disease Progression; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000737:chemistry / Q000378:metabolism*; D011237:Predictive Value of Tests; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000737:chemistry / Q000378:metabolism* / Q000601:surgery*; D029584:Prostatic Secretory Proteins / Q000032:analysis / Q000096:biosynthesis*
chemical_list: D029584:Prostatic Secretory Proteins; C043076:beta-microseminoprotein