Comparison of enzymatic and microbiological gentamicin assays.
The correlation coefficient between the rapid enzymatic and the overnight microbiological assays for 211 urine and serum specimens was 0.96. The 95% confidence limits yielded a correlation coefficient between 0.92 and 0.98. Both methods tended to underestimate the amount of a gentamicin added to urine. When only serum samples were considered, the predicted value obtained from the linear regression analysis of either method was within 0.57 mug/ml 99% of the time. This high degree of positive correlation will permit safe rapid adjustment of individualized patient gentamicin dosages.
Smith
A L
AL
Waitz
J A
JA
Smith
D H
DH
Oden
E M
EM
Emerson
B B
BB
D000900:Anti-Bacterial Agents / Q000032:analysis*; D005839:Gentamicins / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D009713:Nucleotidyltransferases / Q000378:metabolism; D012044:Regression Analysis
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D009713:Nucleotidyltransferases; C020565:gentamicin 2''-nucleotidyltransferase