Sensing cell stress and transformation through Vgamma9Vdelta2 T cell-mediated recognition of the isoprenoid pathway metabolites.
Vgamma9Vdelta2 cells, a major peripheral blood gammadelta T cell subset in adults, recognize non-peptidic phosphorylated metabolites referred to as phosphoantigens (phosphoAg), which are produced by a broad array of prokaryotic and eukaryotic organisms. We will review here the biosynthetic pathways leading to production of phosphoAg and our current understanding of the mode of activation of Vgamma9Vdelta2 cells by these compounds. We will also discuss the physiological relevance of this immune recognition process and show how it can enable discrimination by Vgamma9Vdelta2 lymphocytes of infected and/or transformed cells.
Bonneville
Marc
M
Inserm U601, Institut de Biologie, 9 quai Moncousu, 44035 Nantes cedex 1, France.
Fournié
Jean-Jacques
JJ
D000941:Antigens / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D011971:Receptors, Immunologic / Q000276:immunology; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013729:Terpenes / Q000378:metabolism*
D000941:Antigens; D011971:Receptors, Immunologic; D013729:Terpenes