title: Celiac disease-related antibodies in an epilepsy cohort and matched reference population.
abstract: Celiac disease (CD) is a common immunologically mediated enteropathic condition manifesting in genetically predisposed individuals after exposure to wheat gluten. CD may be associated with a number of neurological disorders, and the prevalence of epilepsy is reported to be increased in patients with CD. We studied the prevalence of CD-associated antibodies in a cohort of 968 patients with epilepsy and in a population-based reference group of 584 subjects. There was no difference in the prevalence of IgA and IgG class antigliadin antibodies (AGAbA and AGAbG, respectively), endomysial antibodies (EMA), and tissue transglutaminase antibodies (tTGAbA) between patients with epilepsy and the control population. This suggests the presence of CD to be the same in patients with epilepsy and the reference population. However, AGAbA was more prevalent in patients with primary generalized epilepsy (19.6%) than in the reference population (10.6%, relative risk 1.8, 95% confidence interval 1.1-3.0, P=0.012).
authors.affiliation: Department of Neurology, Seinäjoki Central Hospital, Seinä-joki, Finland. jouni.ranua@netikka.fi
authors.forename: Jouni
authors.initials: J
authors.lastname: Ranua
authors.forename: Katja
authors.initials: K
authors.lastname: Luoma
authors.forename: Anssi
authors.initials: A
authors.lastname: Auvinen
authors.forename: Markku
authors.initials: M
authors.lastname: Mäki
authors.forename: Anna-Maija
authors.initials: AM
authors.lastname: Haapala
authors.forename: Jukka
authors.initials: J
authors.lastname: Peltola
authors.forename: Jani
authors.initials: J
authors.lastname: Raitanen
authors.forename: Jouko
authors.initials: J
authors.lastname: Isojärvi
mesh_terms: D000906:Antibodies / Q000145:classification / Q000378:metabolism*; D001323:Autoantibodies / Q000276:immunology; D016022:Case-Control Studies; D002446:Celiac Disease / Q000453:epidemiology / Q000276:immunology*; D015331:Cohort Studies; D016001:Confidence Intervals; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D004827:Epilepsy / Q000453:epidemiology / Q000276:immunology*; D005903:Gliadin / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D018485:Muscle Fibers, Skeletal / Q000276:immunology; D016017:Odds Ratio; D011159:Population Surveillance; D015995:Prevalence; D011503:Transglutaminases / Q000276:immunology
chemical_list: D000906:Antibodies; D001323:Autoantibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D005903:Gliadin; D011503:Transglutaminases