[Protective effect of ligusticum chuanxiong phthalides on focai cerebral ischemia in rats and its related mechanism of action].
OBJECTIVE
To study the protective effect of ligusticum chuanxiong phthalides on cerebral ischemia in rats and its related mechanism of action.


METHODS
Middle cerebral artery occlusion (MCAO) model, thrombosis formation, platelet aggregation and hemorrheological parameters were measured to evaluate the protective effect of ligusticum chuanxiong phthalides.


RESULTS
Ligusticum chuanxiong phthalides could markedly decrease the infarct size and behavior deficits score, inhibit the thrombus formation and platelet aggregation, ameliorate hemorrheological parameters with a dose-dependent manner in rats.


CONCLUSIONS
Ligusticum chuanxiong phthalides has protective effects on focal cerebral ischemia in rats, and its mechanism may be relevant to its inhibition of platelet-dependent thrombosis and amelioration of hemorrheological parameters.
Tian
Jing-Wei
JW
School of Pharmacy, Shandong Yantai University, Shandong Engineering Research Center for Natural Drugs, Yamai 264003, China.
Fu
Feng-Hua
FH
Jiang
Wang-Lin
WL
Wang
Chao-Yun
CY
Sun
Fang
F
Zhang
Tai-Ping
TP
D000818:Animals; D001572:Benzofurans / Q000302:isolation & purification / Q000494:pharmacology*; D001809:Blood Viscosity / Q000187:drug effects; D002545:Brain Ischemia / Q000097:blood / Q000473:pathology*; D004305:Dose-Response Relationship, Drug; D006400:Hematocrit; D020244:Infarction, Middle Cerebral Artery / Q000097:blood / Q000473:pathology; D030004:Ligusticum / Q000737:chemistry*; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D020246:Venous Thrombosis / Q000517:prevention & control*
D001572:Benzofurans; D018696:Neuroprotective Agents; C082022:phthalide