title: Systemic T-cell activation in acute clinically isolated optic neuritis.
abstract: We examined untreated 60 patients with acute monosymptomatic optic neuritis (ON). Patients examined early after onset showed increased expression of HLA-DR and CD45R0 on CD4 and CD8 T cells. Expression of HLA-DR on CD4 T cells was higher in patients without IgG oligoclonal bands. Expression of HLA-DR on CD4 and CD8 T cells correlated negatively with measures of disease activity and positively with measures of good visual function, and expression of CD45R0 on CD4 T cells correlated negatively with measures of disease activity. We hypothesize that HLA-DR expression may characterize a protective T-cell subset in ON.
authors.affiliation: The MS Clinic, Department of Neurology, University of Copenhagen, Glostrup Hospital, DK-2600 Glostrup, Denmark. roeden@dadlnet.dk
authors.forename: Hanne
authors.initials: H
authors.lastname: Roed
authors.forename: Jette
authors.initials: J
authors.lastname: Frederiksen
authors.forename: Annika
authors.initials: A
authors.lastname: Langkilde
authors.forename: Torben Lykke
authors.initials: TL
authors.lastname: Sørensen
authors.forename: Martin
authors.initials: M
authors.lastname: Lauritzen
authors.forename: Finn
authors.initials: F
authors.lastname: Sellebjerg
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology*; D018414:CD8-Positive T-Lymphocytes / Q000502:physiology*; D005074:Evoked Potentials, Visual / Q000502:physiology; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D005786:Gene Expression Regulation / Q000502:physiology; D006684:HLA-DR Antigens / Q000097:blood / Q000134:cerebrospinal fluid; D006801:Humans; D017493:Leukocyte Common Antigens / Q000097:blood / Q000134:cerebrospinal fluid; D008213:Lymphocyte Activation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009902:Optic Neuritis / Q000097:blood / Q000134:cerebrospinal fluid / Q000473:pathology* / Q000503:physiopathology; D014785:Vision, Ocular / Q000502:physiology
chemical_list: D006684:HLA-DR Antigens; D017493:Leukocyte Common Antigens