title: Unreality symptoms and volumetric measures of Heschl's gyrus and planum temporal in first-episode psychosis.
abstract: BACKGROUND
  Schizophrenia may involve dysfunction to primary auditory, speech, and language processes governed by the superior temporal gyrus (STG). These processes are implicated in hallucinations, delusions, and thought disorder. The current study explored the relationship between unreality symptoms (hallucinations and delusions) and specific STG substructures, including Heschl's gyrus (HG) and planum temporale (PT).
  
  
  METHODS
  Twenty-five right-handed men within their first episode of psychosis were assessed using the Positive and Negative Syndrome Scale (PANSS) for the presence of hallucinations and delusional behavior (a composite score of delusions, grandiosity, suspiciousness, and unusual thought content). T1-weighted magnetic resonance imaging (MRI) scans were acquired using a 1.5 Tesla scanner. Stereological measurements of HG and PT volume were obtained. Linear regression methods explored the relationship between regional volumes and symptoms.
  
  
  RESULTS
  Reductions in left HG were associated with hallucinations and delusions. Increases in left PT were associated with delusional behavior.
  
  
  CONCLUSIONS
  Current results implicate HG dysfunction in unreality symptoms in men with recent-onset schizophrenia.
authors.affiliation: BIAU, Biostatistics and Computing, Institute of Psychiatry, London, UK. a.sumich@iop.kcl.ac.uk
authors.forename: Alex
authors.initials: A
authors.lastname: Sumich
authors.forename: Xavier A
authors.initials: XA
authors.lastname: Chitnis
authors.forename: Dominic G
authors.initials: DG
authors.lastname: Fannon
authors.forename: Séamus
authors.initials: S
authors.lastname: O'Ceallaigh
authors.forename: Victor C
authors.initials: VC
authors.lastname: Doku
authors.forename: Abi
authors.initials: A
authors.lastname: Faldrowicz
authors.forename: Tonmoy
authors.initials: T
authors.lastname: Sharma
mesh_terms: D000328:Adult; D003702:Delusions / Q000503:physiopathology / Q000523:psychology; D007839:Functional Laterality / Q000502:physiology; D006212:Hallucinations / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D011569:Psychiatric Status Rating Scales; D012565:Schizophrenic Psychology; D013702:Temporal Lobe / Q000502:physiology*