[Effects of Alternanthera philoxeroides Griseb against dengue virus in vitro].
OBJECTIVE
To investigate the effects of Alternanthera philoxeroides Griseb extracts against dengue virus in vitro.


METHODS
MTT assay and observation of cytopathic effect (CPE) were carried out to determine the cytotoxicity of Alternanthera philoxeroides Griseb on C6/36 cell lines and its effects on dengue virus.


RESULTS
None of the 4 kinds of Alternanthera philoxeroides Griseb extracts exhibited obvious cytotoxicity on the cells at different concentrations with the exception of that over 320 microg/ml. The 4 extracts all showed inhibitory effects on dengue virus. Statistical analysis of TD(50) and ED(50) by Probit regression method suggested that extracts from coumarin had the lowest toxicity on the cells (TD(50)=535.91), whereas extracts from petroleum ether showed the strongest inhibitory effects on dengue virus (ED(50)=47.43) among the 4 extracts.


CONCLUSIONS
Alternanthera philoxeroides Griseb possesses antiviral effects on dengue virus in vitro.
Jiang
Wen-Ling
WL
Medical Research Center of People's Hospital of Guangdong Province, Guangzhou 510080, China. jwenling@126.com
Luo
Xian-Ling
XL
Kuang
Su-Juan
SJ
D027703:Amaranthaceae / Q000737:chemistry*; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000633:toxicity; D003716:Dengue Virus / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000633:toxicity
D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal