title: The relationship between anticardiolipin antibodies and vascular access occlusion in patients on hemodialysis.
abstract: Vascular access occlusion is frequently seen in some patients on hemodialysis. There are different opinions about pathogenesis of recurrent access thrombosis. Anticardiolipin (aCL) antibodies have been suggested to be involved in thrombosis and can be found in a high proportion of patients with chronic renal failure. We investigated the relationship between vascular access occlusion and the level of aCL antibodies in hemodialysis patients. We measured serum IgG and IgM aCL antibodies and protein C levels in 50 patients on hemodialysis having no fistule thrombosis (group 1), in 33 patients on hemodialysis with fistule thrombosis (group 2), and 20 nondialyzed patients with chronic renal failure (group 3). There were no differences in age and duration on hemodialysis (p > 0.05). No significant correlation was found between protein C and platelet counts in all groups (p > 0.05). In group 1, aCL IgG and IgM were 2%. In group 2, aCL IgG and IgM were 6.06% and 0%, respectively. In group 3, aCL IgG and IgM were negative. We did not find any significant difference between aCL IgG and IgM in all groups (p > 0.05). No association was found between aCL antibodies and vascular access thrombosis in our patients on hemodialysis.
authors.affiliation: Department of Internal Medicine, Cumhuriyet University, Faculty of Medicine Sivas, Turkey.
authors.forename: Füsun
authors.initials: F
authors.lastname: Gültekin
authors.forename: Hakan
authors.initials: H
authors.lastname: Alagözlü
authors.forename: Ferhan
authors.initials: F
authors.lastname: Candan
authors.forename: Işilay
authors.initials: I
authors.lastname: Nadir
authors.forename: Mustafa Zahir
authors.initials: MZ
authors.lastname: Bakici
authors.forename: Hafize
authors.initials: H
authors.lastname: Sezer
mesh_terms: D000368:Aged; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D001166:Arteriovenous Shunt, Surgical / Q000009:adverse effects*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D013927:Thrombosis / Q000209:etiology*
chemical_list: D017153:Antibodies, Anticardiolipin; D007074:Immunoglobulin G; D007075:Immunoglobulin M