[Prognostic markers in gastric neuro-endocrine carcinoma].
Gastric endocrine tumors show a wide spectrum of clinical pathologic features. Behaviour prognostic evaluation of these tumors is difficult. The aim of this report is to present a rare case of a neuroendocrine carcinoma with multiple locations in stomach.


METHODS
A 62 years female patient underwent a resection of stomach for a tumor. The paraffin-embedded sections of 12 blocks were studied by histological and immunohistochemical methods including HE, van Gieson, Grimelius, chromogranin A, cytokeratin, neuron-specific enolase, vimentin, desmin, smooth muscle actin, Ki-67 antigen, protein S-100.


RESULTS
Histological pattern was similar in primary tumor (mucosa and submucosa) and sessile lesion at distance, where it affected only mucosa. Histopathologically, these tumors show a sheet of round to spindle and polyhedral neoplastic cells with hyperchromatic nuclei, considerable mitotic activity. Immunohistochemically, the neoplastic cells were positive for cytokeratin and neuron-specific enolase and a high Ki-67 labelling index. The three lymph nodes from five had metastasis.


CONCLUSIONS
The IHC reactions were needed for diagnosis of multiple neuroendocrine carcinomas with lymph node metastasis. These histological and immunohistochemical criteria were very important for the identification of tumors with the aggressive evolution.
Mihailovici
Maria Sultana
MS
Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi, Facultatea de Medicină, Disciplina Morfopatologie.
Ivan
Luminiţa
L
Plămădeală
P
P
Ferariu
D
D
Scripcariu
V
V
D014408:Biomarkers, Tumor / Q000032:analysis*; D018278:Carcinoma, Neuroendocrine / Q000201:enzymology / Q000276:immunology / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008207:Lymphatic Metastasis; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D011237:Predictive Value of Tests; D011379:Prognosis; D013274:Stomach Neoplasms / Q000201:enzymology / Q000276:immunology / Q000473:pathology*
D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D010751:Phosphopyruvate Hydratase