Effect of chronic exposure to cadmium on the mineral status and mechanical properties of lumbar spine of male rats.
The effect of cadmium (Cd) on the risk of vertebral damage was investigated on a male rat model of human exposure. Young Wistar rats were treated with Cd in drinking water at the concentration of 1, 5 or 50 mgCd/l for 12 months. Bone mineral density (BMD) of the lumbar spine (L1-L5), the rate of deformities and fractures, biomechanical properties (compression test) and the chemical composition of the fourth lumbar vertebral body (L4) were estimated. The exposure to 1 mgCd/l (corresponding to low environmental exposure in non-Cd-polluted areas) had no effect on the L4 composition, density and mechanical strength; in one animal only (10%) it was deformed. In the 5 mgCd/l group, the content of minerals (including calcium, zinc and phosphate) in the L4 and the displacement at ultimate decreased, whereas its ultimate strength and the L1-L5 BMD tended to decline. In most of the rats, the L4 was intact and there were no vertebral fractures. At 50 mgCd/l, the BMD of the L1-L5 and the content of minerals in the L4 (including calcium, magnesium, zinc, copper, iron and phosphate) were lower compared to control, and these changes were accompanied by a weakness in the L4 mechanical strength. The L4 was intact only in 30% of these rats; in other animals it was deformed (40%) or fractured (30%). The results allow for the conclusion that moderate environmental exposure to Cd (5 mgCd/l in the model applied) may enhance the risk of vertebral damage in men. These, together with our previous findings on an analogous female rat model, seem to indicate that males may be less vulnerable to the vertebral fractures due to exposure to Cd compared to females.
Brzóska
Malgorzata M
MM
Department of Toxicology, Medical University of Bialystok, Mickiewicza 2C Street, 15-222 Bialystok, Poland. mmbr@poczta.onet.pl
Moniuszko-Jakoniuk
Janina
J
D000284:Administration, Oral; D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D019256:Cadmium Chloride / Q000633:toxicity*; D019245:Compressive Strength / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004785:Environmental Pollutants / Q000633:toxicity*; D008159:Lumbar Vertebrae / Q000187:drug effects* / Q000293:injuries / Q000378:metabolism / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D016103:Spinal Fractures / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology
D004785:Environmental Pollutants; D019256:Cadmium Chloride