title: Deep-brain stimulation in the subthalamic nuclei improves balance performance in patients with Parkinson's disease, when tested without anti-parkinsonian medication.
abstract: OBJECTIVE
  To evaluate the effect of bilateral deep-brain stimulation (DBS) in the subthalamic nucleus (STN) on balance performance in patients with severe Parkinson's disease (PD), when tested without anti-parkinsonian medication.
  
  
  METHODS
  Thirty-one patients (median age 65 years, range 50-77) were included. Assessments were made after 10-12 h withdrawal of medication, before and 6 and 12 months after surgery. Postoperative evaluations were performed with DBS on and off. Balance performance was evaluated with the Berg Balance Scale (BBS). Motor symptoms and postural stability (item 30) were assessed with the Unified Parkinson's Disease Rating Scale (UPDRS III).
  
  
  RESULTS
  DBS in STN improved balance performance as well as postural stability and motor symptoms significantly (P </= 0.001). Seventy per cent of the patients improved their total score of the BBS with DBS on compared with DBS off. Thus, at 6 months their median improvement was 6 points (q1-q3, 4-11) and at 12 months 4 points (2.5-16).
  
  
  CONCLUSIONS
  DBS in STN improves balance performance in patients with severe PD.
authors.affiliation: Department of Neurosurgery, University Hospital of Lund, Lund, Sweden.
authors.forename: M H
authors.initials: MH
authors.lastname: Nilsson
authors.forename: A L
authors.initials: AL
authors.lastname: Törnqvist
authors.forename: S
authors.initials: S
authors.lastname: Rehncrona
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000008:administration & dosage; D046690:Deep Brain Stimulation; D004567:Electrodes, Implanted; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000628:therapy*; D004856:Postural Balance; D020531:Subthalamic Nucleus / Q000502:physiology*; D016896:Treatment Outcome
chemical_list: D000978:Antiparkinson Agents