Biophysics of aging and therapeutic interventions by entropy-variation systems.
The cell is thermodynamically an open system and aging is characterized by an increasingly higher structural disorder (increase of entropy) and functional loss. If a variation of negative entropy is introduced by an external source, an anti-clockwise effect leading to regenerative processes and/or increase of the functional reserve supporting regenerative tissue changes is theoretically expected. The achievement of a negative variation of entropy is the main principle of a new technology which implies an exogenous delivery of energy with higher performance than the physiological production. Promising clinical experiences in liver cirrhosis and in long-standing scarring lesions seem to confirm the clinical applicability of the theoretical model.
Marineo
G
G
Delta Research & Development, Tor Vergata University of Rome, Italy.
Marotta
F
F
D000375:Aging / Q000378:metabolism / Q000502:physiology*; D004574:Electromagnetic Fields; D004734:Energy Metabolism; D019277:Entropy; D006801:Humans; D008103:Liver Cirrhosis / Q000378:metabolism / Q000628:therapy*; D008115:Liver Regeneration; D008954:Models, Biological; D044968:Regenerative Medicine / Q000379:methods