title: Prediction of the ability of clozapine to treat negative symptoms from plasma glycine and serine levels in schizophrenia.
abstract: We previously reported that plasma levels of glycine, a co-agonist at N-methyl-D-asparate (NMDA)-type glutamate receptors, are decreased in patients with schizophrenia, and that glycine levels are negatively correlated with negative symptoms. The aim of the present study was to determine if glycine, or its ratio to serine, a precursor of glycine, predicts change in negative symptoms in subjects with schizophrenia during treatment with clozapine, an atypical antipsychotic drug with multiple effects on glutamatergic activity. Plasma levels of glycine, serine, and their ratio, were measured in 44 patients with schizophrenia who were subsequently treated with clozapine. Baseline glycine levels or glycine/serine ratios predicted the Scale for the Assessment of Negative Symptoms - Sum of the Global Scales and Avolition-Apathy after 6 wk of clozapine treatment. These results indicate the association of these amino acid measures with response to clozapine in terms of negative symptoms in patients with schizophrenia.
authors.affiliation: Department of Psychiatry, Division of Psychopharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA. sumiyo@ms.toyama-mpu.ac.jp
authors.forename: Tomiki
authors.initials: T
authors.lastname: Sumiyoshi
authors.forename: Dai
authors.initials: D
authors.lastname: Jin
authors.forename: Karu
authors.initials: K
authors.lastname: Jayathilake
authors.forename: Myung
authors.initials: M
authors.lastname: Lee
authors.forename: Herbert Y
authors.initials: HY
authors.lastname: Meltzer
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003024:Clozapine / Q000627:therapeutic use*; D005260:Female; D005998:Glycine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology; D012565:Schizophrenic Psychology; D012694:Serine / Q000097:blood*
chemical_list: D014150:Antipsychotic Agents; D012694:Serine; D003024:Clozapine; D005998:Glycine