Starch/Carbopol spray-dried mixtures as excipients for oral sustained drug delivery.
The present study evaluated if mixtures prepared by spray-drying an aqueous dispersion of Amioca starch and Carbopol 974P could be used as matrix for oral sustained drug delivery. The influence of the Amioca/Carbopol 974P ratio (0/100, 25/75, 50/50, 60/40, 85/15, 90/10, 95/5 and 100/0) and the pH and ionic strength (mu) of the dissolution medium on the drug release was investigated. The matrices composed of the spray-dried mixtures with 10% or 15% Carbopol 974P sustained the drug release over the longest time period. At this Carbopol concentration, shear viscosity measurements indicated the formation of an optimal network between the polymer chains of Amioca starch and Carbopol 974P, forming a rigid gel layer offering resistance to erosion during the dissolution experiments.
Pringels
E
E
Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Gent, Belgium.
Ameye
D
D
Vervaet
C
C
Foreman
P
P
Remon
J P
JP
D000180:Acrylic Resins; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004339:Drug Compounding; D005079:Excipients / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry*; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013213:Starch / Q000737:chemistry*; D013499:Surface Properties; D013607:Tablets; D013806:Theophylline / Q000008:administration & dosage; D014665:Vasodilator Agents / Q000008:administration & dosage; D014783:Viscosity; D014867:Water / Q000737:chemistry
D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D005079:Excipients; D011145:Polyvinyls; D013607:Tablets; D014665:Vasodilator Agents; D014867:Water; C006912:carboxypolymethylene; D013213:Starch; D013806:Theophylline