Protective effect of antioxidants on brain oxidative damage caused by proline administration.
We have previously demonstrated that acute and chronic hyperprolinemia induce oxidative stress in cerebral cortex of rats. In the present study, we investigated the action of Vitamins E and C on the oxidative damage elicited by acute and chronic administration of proline (Pro) in rat cerebral cortex. Results showed that treatment with Vitamins E and C prevented the alterations caused by acute and chronic administration of proline on chemiluminescence, total radical-trapping antioxidant potential (TRAP) and on the activities of catalase and glutathione peroxidase. If these effects also occur in the human condition, it is possible that antioxidant administration might serve as a potential adjuvant therapy to avoid the progression of the neuropsychiatric dysfunction observed in hyperprolinemic patients.
Delwing
Daniela
D
Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, CEP 90035-003 Porto Alegre, RS, Brazil.
Chiarani
Fábria
F
Bavaresco
Caren S
CS
Wannmacher
Clóvis M D
CM
Wajner
Moacir
M
Dutra-Filho
Carlos S
CS
Wyse
Angela T S
AT
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects*; D002374:Catalase / Q000187:drug effects / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000187:drug effects / Q000378:metabolism; D008163:Luminescent Measurements; D018384:Oxidative Stress / Q000187:drug effects*; D011392:Proline / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D014810:Vitamin E / Q000627:therapeutic use
D000975:Antioxidants; D014810:Vitamin E; D011392:Proline; D002374:Catalase; D005979:Glutathione Peroxidase; D001205:Ascorbic Acid