title: Long-lasting CD3+ T-cell deficiency after cord blood stem cell transplantation in a human herpesvirus 6-infected child.
abstract: We report a long-lasting (8-month) reactivation of human herpesvirus 6 (HHV-6) infection in child who had undergone cord blood stem cell transplantation. The reactivation was characterized by high viral loads and by immediate-early mRNA positivity. HHV-6 infection was associated with a deep depletion of CD3, while the CD4/CD8 ratio remained substantially unchanged.
authors.affiliation: Department of Public Medicine Sciences, University of Trieste, Trieste, Italy.
authors.forename: Manola
authors.initials: M
authors.lastname: Comar
authors.forename: Pierlanfranco
authors.initials: P
authors.lastname: D'Agaro
authors.forename: Douglas
authors.initials: D
authors.lastname: Horejsh
authors.forename: Monica
authors.initials: M
authors.lastname: Galvan
authors.forename: Simona
authors.initials: S
authors.lastname: Fiorentini
authors.forename: Marino
authors.initials: M
authors.lastname: Andolina
authors.forename: Arnaldo
authors.initials: A
authors.lastname: Caruso
authors.forename: Dario
authors.initials: D
authors.lastname: Di Luca
authors.forename: Cesare
authors.initials: C
authors.lastname: Campello
mesh_terms: D017252:CD3 Complex / Q000378:metabolism*; D016516:CD4-CD8 Ratio; D002648:Child; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects*; D015654:Herpesvirus 6, Human / Q000502:physiology*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000209:etiology*; D008297:Male; D019349:Roseolovirus Infections / Q000209:etiology* / Q000821:virology; D013601:T-Lymphocytes / Q000166:cytology*; D014775:Virus Activation
chemical_list: D017252:CD3 Complex