title: [Comparative study on effects of puerarin and granulocyte colony-stimulating factor in treating acute myocardial infarction].
abstract: OBJECTIVE
  To compare the effects of puerarin and granulocyte colony-stimulating factor (G-CSF) in treating acute myocardial infarction (AMI) and on the size of infarcted area and cytokines.
  
  
  METHODS
  Seventy-nine patients with anterior AMI were randomly divided into three groups, they were treated with conventional Western medical treatment, but to the puerarin group (PG) and the G-CSF group (GCG) puerarin and G-CSF was given additionally, respectively. The infarcted size, plasma G-CSF, matrix metalloproteinase-9 (MMP-9), serum interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) were detected before and after treatment.
  
  
  RESULTS
  The infarcted size was positively correlated to the levels of G-CSF, MMP-9, IL-6 and TNF-alpha before treatment ( r = 0.45, 0.42, 0.44 and 0.42, P<0.01 ). The infarcted size in the PG and the GCG decreased on the 28th day (P<0.01), the level of G-CSF, MMP-9, IL-6 and TNF-alpha in the PG on the 7th day all decreased (P<0.05), but these indexes in the GCG increased (P<0.05), while those in the control group were unchanged (P>0.05).
  
  
  CONCLUSIONS
  Puerarin and G-CSF are effective in decreasing infarcted size, but their effects on cytokines are different entirely.
authors.affiliation: Department of Cardiovascular Diseases, Yuebei People's Hospital of Guangdong Province, Shaoguan, Guangdong.
authors.forename: Li-zhong
authors.initials: LZ
authors.lastname: Xiao
authors.forename: Ling-jun
authors.initials: LJ
authors.lastname: Gao
authors.forename: Shao-chun
authors.initials: SC
authors.lastname: Ma
mesh_terms: D000368:Aged; D018952:Antigens, CD34 / Q000378:metabolism; D004359:Drug Therapy, Combination; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D007529:Isoflavones / Q000627:therapeutic use*; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D008517:Phytotherapy; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D018952:Antigens, CD34; D015850:Interleukin-6; D007529:Isoflavones; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D020780:Matrix Metalloproteinase 9; C033607:puerarin