Syntheses, antifeedant activity, and QSAR analysis of new oxa(thia)diazolyl 3(2H)-pyridazinones.
Twenty-eight new oxa(thia)diazolyl 3(2H)-pyridazinone derivatives were synthesized. Some compounds showed good chronic growth activities against the armyworm, Pseudaletia separata (Walker). Their EC50 values were determined in vivo. Nineteen 2-tert-butyl-4-chloro-5-[5'-aryl-2'-(1',3',4'-oxadiazolyl)methoxy]-3(2H)-pyridazinones were quantitatively analyzed using the QSAR procedure. The partial least squares method was applied to find relationships between activity and the physicochemical data. The results showed that dipole moment, molar refractivity, and log P are identified as critical parameters for chronic growth effects.
Cao
Song
S
Institute of Pesticides and Pharmaceuticals, East China University of Science and Technology, P.O. Box 544, 130 Meilong Road, Shanghai 200237, China. scao@ecust.edu.cn
Wei
Na
N
Zhao
Chuanmeng
C
Li
Lina
L
Huang
Qingchun
Q
Qian
Xuhong
X
D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004435:Eating / Q000187:drug effects; D007306:Insecticides / Q000138:chemical synthesis*; D009036:Moths; D010069:Oxadiazoles / Q000138:chemical synthesis*; D011724:Pyridazines / Q000138:chemical synthesis*; D021281:Quantitative Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis*
D007306:Insecticides; D010069:Oxadiazoles; D011724:Pyridazines; D013830:Thiadiazoles