Oral contraceptives and polyp regression in familial adenomatous polyposis.
Epidemiologic and experimental reports suggest that female hormones protect against the development of colorectal cancer, but studies are limited. We describe a patient in the placebo arm of a 4-year primary chemoprevention trial who developed adenomatous polyps and then had eradication of polyps after the administration of oral contraceptives. No change in the prostaglandin levels in the colonic mucosa was noted after polyp elimination, making nonsteroidal anti-inflammatory drug ingestion unlikely as a cause. This report represents the regression of colorectal adenomas with the use of estrogen/progesterone compounds.
Giardiello
Francis M
FM
Department of Medicine, The Johns Hopkins University School f Medicine, Baltimore, MD 21205, USA.
Hylind
Linda M
LM
Trimbath
Jill D
JD
Hamilton
Stanley R
SR
Romans
Katharine E
KE
Cruz-Correa
Marcia
M
Corretti
Mary C
MC
Offerhaus
G Johan A
GJ
Yang
Vincent W
VW
D011125:Adenomatous Polyposis Coli / Q000503:physiopathology*; D002648:Child; D003106:Colon / Q000378:metabolism; D003276:Contraceptives, Oral / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D008599:Menstruation Disturbances / Q000188:drug therapy; D011453:Prostaglandins / Q000378:metabolism; D012074:Remission Induction
D003276:Contraceptives, Oral; D011453:Prostaglandins