title: Mending human genes: a job for a lifetime.
abstract: I have described a number of milestones along a career of nearly 40 years in DNA repair. Most important was the discovery that the human disease xeroderma pigmentosum represented mutations in various components of nucleotide excision repair. This ushered in a new field of research involving numerous investigators and which continues to expand and amaze.
authors.affiliation: Auerback Melanoma Laboratory, UCSF Cancer Center, Box 0808, Room N431, University of California, San Francisco, CA 94143-0808, USA. jcleaver@cc.ucsf.edu
authors.forename: James E
authors.initials: JE
authors.lastname: Cleaver
mesh_terms: D004249:DNA Damage; D004260:DNA Repair; D004273:DNA, Neoplasm / Q000528:radiation effects; D049673:History, 20th Century; D006801:Humans; D012867:Skin / Q000528:radiation effects; D012878:Skin Neoplasms / Q000235:genetics / Q000266:history*; D013472:Sunlight / Q000009:adverse effects; D014983:Xeroderma Pigmentosum / Q000235:genetics / Q000266:history*
chemical_list: D004273:DNA, Neoplasm