title: Asymmetric hydrogenation of isobutyrophenone using a [(Diphosphine) RuCl2 (1,4-diamine)] catalyst.
abstract: [reaction: see text] The use of three chiral 1,4-diamines in the [(diphosphine) RuCl(2) (diamine)] catalyst system is demonstrated in the hydrogenation of acetophenone. The use of a 1,4-diamine offers unique properties that allow tuning of the catalyst system. These include the first example of the use of a racemic diamine in combination with a chiral phosphine, which gives 95% ee in the hydrogenation of isobutyrophenone.
authors.affiliation: Johnson Matthey Catalysis and Chiral Technologies, Unit 28, Cambridge Science Park, Milton Road, Cambridge, UK.
authors.forename: Gabriela A
authors.initials: GA
authors.lastname: Grasa
authors.forename: Antonio
authors.initials: A
authors.lastname: Zanotti-Gerosa
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Medlock
authors.forename: William P
authors.initials: WP
authors.lastname: Hems