Clinical, histopathological and virological findings in patients with focal epithelial hyperplasia from Colombia.
BACKGROUND
Focal epithelial hyperplasia (FEH) is a rare oral HPV-related disease, highly prevalent in certain ethnic communities. A previous study found 7.5% prevalence among school children from the Indian community Embera-Chami in Colombia.


OBJECTIVE
To determine the prevalence and Human Papillomavirus (HPVs)-type in children with FEH.


METHODS
One hundred and thirty-eight students were screened. All FEH samples were HPV-tested by two PCR-based systems.


RESULTS
We identified 18 FEH cases. beta-globin amplification was obtained in 15 cases and nine were HPV-55-positive by the HPV-PCR-hybridization method. Nine cases (50%) were HPV-13-positive by the GP5+/GP6+-based method. Twelve cases (80%) were HPV-positive by one or the other method. Forty-four percent and 88% of interviewed parents reported family histories of FEH and toothbrush sharing, respectively.


CONCLUSIONS
Human Papillomavirus-DNA was identified in the majority of FEH cases and HPV-13 was the only genotype involved. Frequent familiar infection suggests interfamiliar transmission, genetic predisposition or infection susceptibility among family members.
González
Leonor V
LV
Group Infection and Cancer, School of Dentistry, Dermatology Section, Department of Internal Medicine, School of Medicine, University of Antioquia, Medellín, Colombia.
Gaviria
Angela M
AM
Sanclemente
Gloria
G
Rady
Peter
P
Tyring
Stephen K
SK
Carlos
Roman
R
Correa
Luis A
LA
Sanchez
Gloria I
GI
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003105:Colombia / Q000453:epidemiology; D005260:Female; D017573:Focal Epithelial Hyperplasia / Q000175:diagnosis* / Q000821:virology*; D006801:Humans; D008297:Male; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications* / Q000453:epidemiology*; D015995:Prevalence