Thermal and nutritional modulation of sleep in infant rats.
Infant rats cycle rapidly between periods of high muscle tone (indicative of wakefulness) and periods of atonia (indicative of sleep). Here, the influence of air temperature on sleep in 8-day-old rats was examined by testing pups at thermoneutrality (35 degrees C) and during moderate (28 degrees C) and extreme (20 degrees C) cold challenge; also, pups were tested 1, 4, and 8 hr after infusion of milk to assess the effects of food deprivation on sleep. Whereas moderate cooling slightly reduced sleep durations and altered the temporal patterning of myoclonic twitching, extreme cooling substantially decreased sleep durations and inhibited twitching. In contrast, food deprivation had little effect. Therefore, thermoregulatory mechanisms engaged during moderate cooling sustain sleep, whereas extreme cooling overwhelms these mechanisms, thereby promoting arousal.
Seelke
Adele M H
AM
Program in Behavioral and Cognitive Neuroscience, Department of Psychology, University of Iowa, Iowa City, IA 52242, USA.
Blumberg
Mark S
MS
D000818:Animals; D000831:Animals, Newborn; D001833:Body Temperature Regulation; D005260:Female; D005508:Food Deprivation; D008297:Male; D009752:Nutritional Status; D051381:Rats; D012890:Sleep / Q000502:physiology*; D013696:Temperature