title: Efficacy of three adhesion-preventing agents in reducing severe peritoneal trauma induced by bipolar coagulation in a laparoscopic rat model.
abstract: OBJECTIVE
  To compare the antiadhesion efficacy of three agents (4% icodextrin, ferric hyaluronate gel, and Ringer's lactate) in severe peritoneal trauma caused by bipolar coagulation in a laparoscopic rat model.
  
  
  METHODS
  Prospective, randomized, blinded experimental study.
  
  
  METHODS
  International Laparoscopic Surgery Centre, Clermont-Ferrand, France.
  
  
  METHODS
  Female Sprague-Dawley rats.
  
  
  METHODS
  Animals were prospectively randomized to receive one of the three agents or to be controls. Coagulation of the parietal peritoneum was performed using a bipolar 40-W current followed by administration of an antiadhesion agent. Postoperative adhesion assessment was carried out on day 7 in 42 rats.
  
  
  METHODS
  Adhesions were scored according to their extent and severity.
  
  
  RESULTS
  Adhesions occurred in all rats, however, adhesion and vascular adhesion rate scores were significantly higher in controls compared with treated groups. Adhesions were more likely to be filmy and easily separable in the 4% icodextrin group compared with the Ringer's lactate solution group.
  
  
  CONCLUSIONS
  Adhesion scores were decreased by the use of antiadherent agents. However, no rats were found to be free of adhesions after severe peritoneal trauma induced by 40-W bipolar coagulation of the peritoneum.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Medicine, University Hospital Clermont-Ferrand, Polyclinique, Boulevard Leon Malfreyt, 63033 Clermont-Ferrand, France. horace.roman@libertysurf.fr
authors.forename: Horace
authors.initials: H
authors.lastname: Roman
authors.forename: Michel
authors.initials: M
authors.lastname: Canis
authors.forename: Meenal
authors.initials: M
authors.lastname: Kamble
authors.forename: Revaz
authors.initials: R
authors.lastname: Botchorishvili
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Pouly
authors.forename: Gérard
authors.initials: G
authors.lastname: Mage
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004564:Electrocoagulation / Q000009:adverse effects*; D005260:Female; D005290:Ferric Compounds / Q000494:pharmacology; D005782:Gels; D005936:Glucans / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology*; D006820:Hyaluronic Acid / Q000494:pharmacology; D000077607:Icodextrin; D007552:Isotonic Solutions / Q000494:pharmacology; D010535:Laparoscopy / Q000009:adverse effects*; D010537:Peritoneum / Q000601:surgery*; D011183:Postoperative Complications / Q000188:drug therapy / Q000517:prevention & control; D051381:Rats; D017207:Rats, Sprague-Dawley; D000077325:Ringer's Lactate; D012720:Severity of Illness Index; D000267:Tissue Adhesions / Q000188:drug therapy / Q000517:prevention & control*
chemical_list: D005290:Ferric Compounds; D005782:Gels; D005936:Glucans; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D000077607:Icodextrin; D006820:Hyaluronic Acid; D005947:Glucose