title: The CD8 memory T cell subsystem: integration of homeostatic signaling during migration.
abstract: The ability of memory CD8 T cells to patrol non-lymphoid tissues represents an effective method whereby proficient immunosurveillance is achieved. From the analysis of memory CD8 T cell migration in vivo, it is clear that tissue-specific factors control trafficking and residence time within tissues. We propose that at least three pools of memory CD8 T cells exist based on migratory capabilities as dictated by their location in the body. Moreover, we hypothesize that the process of acquisition of homeostatic signals in specific tissues, such as the cytokines IL-7 and IL-15, regulates the mobility of memory T cells.
authors.affiliation: Division of Immunology, Department of Medicine, University of Connecticut Health Center, M/C 1319, 263 Farmington Avenue, Farmington, CT 06030-1319, USA.
authors.forename: Kimberly D
authors.initials: KD
authors.lastname: Klonowski
authors.forename: Leo
authors.initials: L
authors.lastname: Lefrançois
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002465:Cell Movement; D016207:Cytokines / Q000378:metabolism; D006706:Homeostasis; D007156:Immunologic Memory; D051379:Mice; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000276:immunology
chemical_list: D016207:Cytokines