[Fluorescence studies on amoxicillin].
The effects of pH, various organic solvents such as acetone, methanol, ethanol, surface-active agent on amoxicillin have been studied in detail. Put in pH=8 buffer solution, amoxicillin has strong fluorescence emission, excitaion wavelength of 277 nm, and emission wavelength of 303 nm. Calibration curve of amoxicillin was linear between 2 x 10(-5) and 2 x 10(-4) mol/L, with a regression coefficient of 0.9996. CTAB can enhance its fluorescence intensity. The results of fluorescence spectra of amoxicillin added with metal ions (Mg2+, Ca2+, Al3+, Ga3+) at pH=12 showed that there are interactions between amoxicillin and metal ions.
Ma
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Test and Analysis Center of Shanxi University, 030006 Taiyuan.
Chen
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L
Huang
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S
D000658:Amoxicillin / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D004355:Drug Stability; D013050:Spectrometry, Fluorescence / Q000379:methods*
D000900:Anti-Bacterial Agents; D000658:Amoxicillin