title: Intraocular pressure variability in patients who reached target intraocular pressure.
abstract: OBJECTIVE
  To assess the intraocular pressure (IOP) variability in patients with primary open angle glaucoma (POAG) under clinical treatment who reached an established target pressure based on isolated office readings.
  
  
  METHODS
  Retrospective analysis of 65 eyes from 65 POAG patients under clinical therapy who submitted to modified diurnal tension curve (mDTC) (measurements at every 3 hours between 8 am and 5 pm) followed by a water drinking test (WDT). All subjects had established target IOP < or =15 mm Hg at 11 am or 2 pm. IOP variability during mDTC or WDT was evaluated.
  
  
  RESULTS
  mDTC revealed IOP measurements > or =17 mm Hg in 16 of 65 eyes (24.6%). Nine eyes (13.8%) presented values > or =18 mm Hg. The highest IOP detected by mDTC was 20 mm Hg in one patient (1.5%). WDT demonstrated IOP values > or =17 mm Hg in 32 of 65 eyes (49.2%). 22 eyes (33.8%) presented values > or =18 mm Hg after water ingestion. Moreover, IOP levels > or =20 mm Hg were observed in 14 eyes (21.5%).
  
  
  CONCLUSIONS
  A great percentage of POAG patients undergoing clinical treatment and with IOP control based on single office measurement present significantly higher IOP measurements when performing mDTC and, especially, the WDT.
authors.affiliation: Glaucoma Department, University of Sao Paulo School of Medicine, Rua Capote Valente 171 Ap 122, São Paulo, SP 05409-000, Brazil. marcelohatanaka@uol.com.br
authors.forename: F K
authors.initials: FK
authors.lastname: Malerbi
authors.forename: M
authors.initials: M
authors.lastname: Hatanaka
authors.forename: R M
authors.initials: RM
authors.lastname: Vessani
authors.forename: R
authors.initials: R
authors.lastname: Susanna
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002940:Circadian Rhythm; D004326:Drinking; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014867:Water
chemical_list: D014867:Water