[Study on pharmacokinetics of emodin in Rhizoma Polygontum Cuspidatum and its compound].
OBJECTIVE
To study the difference in the pharmacokinetics of emodin in Zhiganning capsules and Rhizoma Polygontum Cuspidatum by nonaqueous RP-HPLC.


METHODS
The rats were orally administered with the extraction of Rhizoma Polygontum Cuspidatum and Zhiganning capsules. After hydrolysis and extraction, the content of emodin in the plasma is determined by Nonaqueous RP-HPLC.


RESULTS
The concentration-time profiles of emodin fit two-compartment model. The pharmacokinetics parameters including, t1/2alpha, AUC(0-infinity), CL(s) and C(max) of emodin in the group of Rhizoma Polygontum Cuspidatum were significantly different from these in the group of its compounds.


CONCLUSIONS
There is a significant difference in pharmacokinetics of emodin between zhiganning capsules and the extraction of Rhizoma Polygontum Cuspidatum.
Yao
Shu-Kun
SK
Hebei Medical University, Shijiazhuang 050017, China.
Jiang
Ye
Y
Hao
Xiao-Hua
XH
Liu
Hong-Ju
HJ
Jang
Shao-Hao
SH
Liu
Wei-Na
WN
D000818:Animals; D019540:Area Under Curve; D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification; D004642:Emodin / Q000302:isolation & purification / Q000493:pharmacokinetics*; D005260:Female; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry*; D028502:Polygonum / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D027343:Rhizome / Q000737:chemistry
D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D004642:Emodin