The tension mounts: mechanics meets morphogenesis and malignancy.
The tissue microenvironment regulates mammary gland development and tissue homeostasis through soluble, insoluble and cellular cues that operate within the three dimensional architecture of the gland. Disruption of these critical cues and loss of tissue architecture characterize breast tumors. The developing and lactating mammary gland are also subject to a plethora of tensional forces that shape the morphology of the gland and orchestrate its functionally differentiated state. Moreover, malignant transformation of the breast is associated with dramatic changes in gland tension that include elevated compression forces, high tensional resistance stresses and increased extracellular matrix stiffness. Chronically increased mammary gland tension may influence tumor growth, perturb tissue morphogenesis, facilitate tumor invasion, and alter tumor survival and treatment responsiveness. Because mammary tissue differentiation is compromised by high mechanical force and transformed cells exhibit altered mechanoresponsiveness, malignant transformation of the breast may be functionally linked to perturbed tensional-homeostasis. Accordingly, it will be important to define the role of tensional force in mammary gland development and tumorigenesis. Additionally, it will be critical to identify the key molecular elements regulating tensional-homeostasis of the mammary gland and thereafter to characterize their associated mechanotransduction pathways.
Paszek
Matthew J
MJ
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6383, USA.
Weaver
Valerie M
VM
D000818:Animals; D001696:Biomechanical Phenomena; D002471:Cell Transformation, Neoplastic; D006706:Homeostasis; D006801:Humans; D009024:Morphogenesis; D009369:Neoplasms / Q000473:pathology*