title: Recurrence of migraine with aura due to tacrolimus therapy in a liver transplant recipient successfully treated with sirolimus substitution.
abstract: We report the case of a female liver transplant recipient who developed a recurrence of severe migraine with aura while on tacrolimus therapy with subsequent remission of headache following discontinuation of tacrolimus and substitution with sirolimus therapy. Headaches in transplant-recipient patients have become a new area of interest for headache specialists. In particular, immunosuppressant medications such as cyclosporine, tacrolimus, sirolimus, and OKT3 have been associated with development of headache syndromes in the transplant patient, exacerbation of previous headaches syndromes, and development of encephalopathies including headache as a clinical feature.
authors.affiliation: University of Calgary, Neurosciences, Calgary, Alberta, Canada.
authors.forename: Cory C
authors.initials: CC
authors.lastname: Toth
authors.forename: Kelly
authors.initials: K
authors.lastname: Burak
authors.forename: Werner
authors.initials: W
authors.lastname: Becker
mesh_terms: D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016031:Liver Transplantation; D008875:Middle Aged; D020325:Migraine with Aura / Q000139:chemically induced*; D012008:Recurrence; D020123:Sirolimus / Q000627:therapeutic use*; D016559:Tacrolimus / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D007166:Immunosuppressive Agents; D020123:Sirolimus; D016559:Tacrolimus