5-fluorocytosine and amphotericin B in bronchial secretions.
The penetration into and clearance from bronchial secretions of 5-fluorocytosine and amphotericin B were studied in a dog model. After a single intravenous dose of 35 mg/kg, 5-fluorocytosine intrabronchial concentrations were greater than the minimal inhibitory concentration for 80 to 90% of Candida species. These inhibitory concentrations persisted up to 3 h. In contrast, amphotericin B in intravenous doses of 0.6 and 1.2 mg/kg penetrated the blood-bronchus barrier poorly.
Pennington
J E
JE
Block
E R
ER
Reynolds
H Y
HY
D000666:Amphotericin B / Q000493:pharmacokinetics*; D000818:Animals; D000935:Antifungal Agents / Q000493:pharmacokinetics*; D001980:Bronchi / Q000378:metabolism*; D004285:Dogs; D005437:Flucytosine / Q000493:pharmacokinetics*
D000935:Antifungal Agents; D000666:Amphotericin B; D005437:Flucytosine