title: [Effects of Naomaitai capsule on learning and memory and content of Ach in rat model produced by cerebral ischemia-reperfusion].
abstract: OBJECTIVE
  To observe the effects of Naomaitai capsule on the learning and memory abilities and the content of acetylcholine(Ach) in the brain tissue of the model rat.
  
  
  METHODS
  One vascular dementia(VD) model was produced by occlusion of bilateral common carotid arteries in rats with following steps: ischemia 20 minutes-reperfusion 10 minutes-ischemia 20 minutes. The learning and memory abilities were tested by water maze. The other VD model was formed by 4-vessel occlusion-reperfusion injury in rats. The time of right reflect recovery and the content of Ach in the brain tissue were determined.
  
  
  RESULTS
  Naomaitai capsule can significantly improve the learning and memory abilities of the dementia rats( P < 0.05, P < 0.01), increase the content of Ach (P < 0.05, P < 0.01) and reduce the time of right reflect recovery(P < 0.01).
  
  
  CONCLUSIONS
  Naomaitai capsule can improve the learning and memory abilities by increasing the content of Ach of the VD rats.
authors.affiliation: Guilin Sanjin Pharmaceutical Company Limited, Guilin 541004, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.forename: Yun-Man
authors.initials: YM
authors.lastname: Li
authors.forename: Xiao-Jian
authors.initials: XJ
authors.lastname: Gong
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
authors.forename: Jie-Ming
authors.initials: JM
authors.lastname: Zou
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001923:Brain Chemistry; D002545:Brain Ischemia / Q000378:metabolism; D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D020441:Ginkgo biloba / Q000737:chemistry; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000494:pharmacology; D005894:Panax / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000378:metabolism* / Q000523:psychology
chemical_list: D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D000109:Acetylcholine