title: Clinical presentation of leptospirosis: a retrospective study of 34 patients admitted to a single institution in metropolitan France.
abstract: Leptospirosis has a highly variable clinical presentation, which may be related to different infecting serovars, host factors, or a combination of these. This study investigated retrospectively 34 consecutive patients with serologically confirmed leptospirosis admitted during the period 1992-2002. On admission, the most frequent symptoms were fever (100%), headache (75%), myalgia (55%), arthralgia (45%) and vomiting (39%). Pertinent laboratory findings included lymphopenia (85%), thrombocytopenia (75%), elevated liver enzymes (87%) and renal abnormalities (proteinuria, 77%; haematuria, 58%; elevated serum creatinine, 53%). The study confirmed the variable clinical and biological symptoms of leptospirosis, and indicated that lymphopenia is a common feature of leptospirosis cases.
authors.affiliation: Infectious Diseases and Intensive Care Unit, Pontchaillou University Hospital, Rennes, France.
authors.forename: S
authors.initials: S
authors.lastname: Jauréguiberry
authors.forename: M
authors.initials: M
authors.lastname: Roussel
authors.forename: G
authors.initials: G
authors.lastname: Brinchault-Rabin
authors.forename: A
authors.initials: A
authors.lastname: Gacouin
authors.forename: A
authors.initials: A
authors.lastname: Le Meur
authors.forename: C
authors.initials: C
authors.lastname: Arvieux
authors.forename: C
authors.initials: C
authors.lastname: Michelet
authors.forename: P
authors.initials: P
authors.lastname: Tattevin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D005334:Fever / Q000473:pathology; D005602:France / Q000453:epidemiology; D006761:Hospitals; D006801:Humans; D015994:Incidence; D007362:Intensive Care Units; D007922:Leptospirosis / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D008231:Lymphopenia / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000473:pathology; D012189:Retrospective Studies; D013921:Thrombocytopenia / Q000473:pathology