Preclinical and clinical evaluation of O-[11C]methyl-L-tyrosine for tumor imaging by positron emission tomography.
We performed preclinical and clinical studies of O-[11C]methyl-L-tyrosine, a potential tracer for imaging amino acid transport of tumors by positron emission tomography (PET). Examinations of the radiation-absorbed dose by O-[11C]methyl-L-tyrosine and the acute toxicity and mutagenicity of O-methyl-L-tyrosine showed suitability of the tracer for clinical use. The whole-body imaging of monkeys and healthy humans by PET showed low uptake of O-[11C]methyl-L-tyrosine in all normal organs except for the urinary track and bladder, suggesting that the O-[11C]methyl-L-tyrosine PET has the potential for tumor imaging in the whole-body. Finally, the brain tumor imaging was preliminarily demonstrated.
Ishiwata
Kiichi
K
Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0022, Japan. ishiwata@pet.tmig.or.jp
Tsukada
Hideo
H
Kubota
Kazuo
K
Nariai
Tadashi
T
Harada
Norihiro
N
Kawamura
Kazunori
K
Kimura
Yuichi
Y
Oda
Keiichi
K
Iwata
Ren
R
Ishii
Kenji
K
D000328:Adult; D000818:Animals; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000378:metabolism; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D005260:Female; D000882:Haplorhini; D006801:Humans; D007249:Inflammation / Q000000981:diagnostic imaging / Q000378:metabolism; D008297:Male; D008657:Metabolic Clearance Rate; D009837:Oligodendroglioma / Q000000981:diagnostic imaging* / Q000378:metabolism*; D009928:Organ Specificity; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000009:adverse effects / Q000138:chemical synthesis; D051381:Rats; D016019:Survival Analysis; D014018:Tissue Distribution; D014425:Turpentine; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
C493092:O-(11C)methyl-L-tyrosine; D019275:Radiopharmaceuticals; D014443:Tyrosine; D014425:Turpentine