title: Pharmacokinetics of tobramycin in patients with stable renal impairment, patients undergoing peritoneal dialysis, and patients on chronic hemodialysis.
abstract: The pharmacokinetics of tobramycin were studied in five patients with stable renal impairment, four patients requiring peritoneal dialysis, and four patients on chronic hemodialysis. The half-life of the drug varied with the level of the serum creatinine in the first group of patients, and the average volume of distribution was 15 liters. Only 49% of the administered dose of tobramycin was recovered during 36 h of peritoneal dialysis. The average clearance of tobramycin during hemodialysis was 49.1 ml/min, and 51.5% of the administered dose was recovered during a 6-h dialysis.
authors.forename: G
authors.initials: G
authors.lastname: Jaffe
authors.forename: B R
authors.initials: BR
authors.lastname: Meyers
authors.forename: S Z
authors.initials: SZ
authors.lastname: Hirschman
mesh_terms: D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D001424:Bacterial Infections / Q000188:drug therapy*; D003404:Creatinine / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D010530:Peritoneal Dialysis; D006435:Renal Dialysis; D014031:Tobramycin / Q000493:pharmacokinetics*
chemical_list: D000900:Anti-Bacterial Agents; D003404:Creatinine; D014031:Tobramycin