title: Fertility preservation for young patients with cancer: who is at risk and what can be offered?
abstract: Estimates suggest that by 2010, one in 715 people in the UK will have survived cancer during childhood. With increasing numbers of children cured, attention has focused on their quality of life. We discuss the causes of impaired fertility after cancer treatment in young people, and outline which patients are at risk and how their gonadal function should be assessed. With the report of a livebirth after orthotopic transplantation of cryopreserved ovarian tissue and the continued development of intracytoplasmic sperm injection for men with poor sperm quality, we assess established and experimental strategies to protect or restore fertility, and discuss the ethical and legal issues that arise.
authors.affiliation: Department of Child Life and Health, Division of Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh, UK. Hamish.Wallace@ed.ac.uk <Hamish.Wallace@ed.ac.uk>
authors.forename: W Hamish B
authors.initials: WH
authors.lastname: Wallace
authors.forename: Richard A
authors.initials: RA
authors.lastname: Anderson
authors.forename: D Stewart
authors.initials: DS
authors.lastname: Irvine
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D015925:Cryopreservation; D004992:Ethics, Medical; D005260:Female; D005298:Fertility; D006066:Gonads / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000628:therapy*; D010053:Ovary / Q000637:transplantation; D018570:Risk Assessment; D012662:Semen Preservation; D020554:Sperm Injections, Intracytoplasmic
chemical_list: D000970:Antineoplastic Agents