title: Treatment guidelines for bipolar disorder: a critical review.
abstract: BACKGROUND
  The development of treatment guidelines emerged as an important element so as to standardize treatment and to provide clinicians with algorithms, which would be able to carry research findings to the everyday clinical practice.
  
  
  METHODS
  The MEDLINE was searched with the combination of each one of the key words 'mania', 'manic', 'bipolar', 'manic-depression', 'manic-depressive' with 'treatment guidelines'.
  
  
  RESULTS
  The search was updated until March 1st, 2004 and returned 224 articles. Twenty-seven papers concerning the publication of treatment algorithms were traced.
  
  
  CONCLUSIONS
  Despite supposedly being evidence-based, guidelines for the treatment of bipolar disorder vary significantly across committees or working groups. Overall, however, at the first stage of the mania/hypomania algorithm, monotherapy with lithium, divalproex sodium or olanzapine is generally recommended. At latter stages combination therapy is strongly recommended. It is clearly stated that in bipolar depression antidepressants should be used only in combination with antimanic agents in order to avoid switching of phases. During the maintenance phase all patients should receive antimanic agents, while some may need the addition of antidepressants. The most recent guidelines emphasize the use of atypical antipsychotics for mania and lamotrigine for depression. The main problem with guidelines is that they are rapidly outdated and that the evidence base relies mainly on registration monotherapy trials that hardly reflect treatment in routine clinical conditions.
  
  
  CONCLUSIONS
  Treatment guidelines may be useful to avoid non-evidence-based treatment decisions, but they are quickly out-of-date and may not fully apply to the clinical setting. The more recent guidelines point the value of atypical antipsychotics, lithium, and valproate in the treatment of mania; the role of lithium, lamotrigine, and olanzapine as options for maintenance therapy; and the scarcity of options for the treatment of bipolar depression. Psychoeducation is also supported by most guidelines as an adjunctive treatment.
authors.affiliation: 3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece. kfount@panafonet.gr
authors.forename: K N
authors.initials: KN
authors.lastname: Fountoulakis
authors.forename: E
authors.initials: E
authors.lastname: Vieta
authors.forename: J
authors.initials: J
authors.lastname: Sanchez-Moreno
authors.forename: S G
authors.initials: SG
authors.lastname: Kaprinis
authors.forename: J M
authors.initials: JM
authors.lastname: Goikolea
authors.forename: G S
authors.initials: GS
authors.lastname: Kaprinis
mesh_terms: D000465:Algorithms; D000928:Antidepressive Agents / Q000627:therapeutic use; D018692:Antimanic Agents / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000188:drug therapy*; D019317:Evidence-Based Medicine; D006801:Humans; D017410:Practice Guidelines as Topic
chemical_list: D000928:Antidepressive Agents; D018692:Antimanic Agents