Piracetam counteracts the effects of amitriptyline on inhibitory avoidance in CD1 mice.
The purpose of the present work was to study the effects of amitriptyline on animal cognition in relation to some characteristics of its therapeutic effects. The modulation of acute and chronic effects of amitriptyline on inhibitory avoidance in male and female mice by piracetam was investigated. In Experiment 1, mice were subjected to the training phase of inhibitory avoidance conditioning 60 min after acute piracetam (100 mg/kg) or physiological saline administration. Immediately after the behavioural task, they received a single injection of the tricyclic antidepressant amitriptyline (30 mg/kg) or physiological saline. Twenty-four hours later, subjects were tested for avoidance. In Experiment 2, the same doses of amitriptyline and piracetam were chronically administered. Mice were subjected to the training phase of inhibitory avoidance on the 22nd day, and to the test phase 24 h later. Forty-five minutes after test, subjects explored the elevated plus-maze for 5 min in order to assess whether the effects of amitriptyline on avoidance performance may reflect general behavioural changes. Results obtained were that: (a) acute and chronic amitriptyline impaired inhibitory avoidance of male and female mice, (b) piracetam counteracted the effect of acutely administered amitriptyline on inhibitory avoidance, and (c) piracetam counteracted the effects of chronically administered amitriptyline in males but not females in the same learning task. These effects do not seem to be mediated by non-specific drug effects on spontaneous motor activity or anxiety.
Everss
Estrella
E
Department of Psychobiology, Faculty of Psychology, University of Valencia, Blasco Ibáñez, 21, 46010 Valencia, Spain.
Arenas
M Carmen
MC
Vinader-Caerols
Concepción
C
Monleón
Santiago
S
Parra
Andrés
A
D000639:Amitriptyline / Q000037:antagonists & inhibitors*; D000704:Analysis of Variance; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000037:antagonists & inhibitors*; D001362:Avoidance Learning / Q000187:drug effects*; D004334:Drug Administration Schedule; D004347:Drug Interactions; D005260:Female; D008297:Male; D008568:Memory / Q000187:drug effects; D051379:Mice; D018697:Nootropic Agents / Q000494:pharmacology*; D010889:Piracetam / Q000494:pharmacology*; D011931:Reactive Inhibition; D012737:Sex Factors; D018709:Statistics, Nonparametric
D000929:Antidepressive Agents, Tricyclic; D018697:Nootropic Agents; D000639:Amitriptyline; D010889:Piracetam