Gut microorganisms, mammalian metabolism and personalized health care.
The mammalian gut microbiota interact extensively with the host through metabolic exchange and co-metabolism of substrates. Such metabolome-metabolome interactions are poorly understood, but might be implicated in the aetiology of many human diseases. In this paper, we assess the importance of the gut microbiota in influencing the disposition, fate and toxicity of drugs in the host, and conclude that appropriate consideration of individual human gut microbial activities will be a necessary part of future personalized health-care paradigms.
Nicholson
Jeremy K
JK
Biomedical Sciences Division, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK. j.nicholson@imperial.ac.uk
Holmes
Elaine
E
Wilson
Ian D
ID
D000818:Animals; D001424:Bacterial Infections / Q000145:classification / Q000517:prevention & control; D041981:Gastrointestinal Tract / Q000382:microbiology; D006801:Humans; D008322:Mammals / Q000378:metabolism*; D012648:Self Care