title: Immune responses to Campylobacter and serum autoantibodies in patients with complex regional pain syndrome.
abstract: We hypothesised that some complex regional pain syndromes (CRPS) may have a postinfectious and/or autoimmune basis. Sera from 92 patients with CRPS and 92 controls were investigated for immunoreactivity to Campylobacter strains and to rodent tissues. Both IgA-antibodies to Campylobacter and tissue-specific reactivity were often present in patients with short disease duration (< or = 1.5 years). Patients with minimal preceding trauma had stronger nervous tissue-specific reactivity than other patients, regardless of disease duration. These results provide preliminary evidence for immune activation early in CRPS and, additionally, that patients with minimal trauma may comprise an autoimmune subgroup.
authors.affiliation: Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Oxford Ox3 9DS, UK. andreasgoebel@rocketmail.com
authors.forename: Andreas
authors.initials: A
authors.lastname: Goebel
authors.forename: Heiko
authors.initials: H
authors.lastname: Vogel
authors.forename: Onassis
authors.initials: O
authors.lastname: Caneris
authors.forename: Zahid
authors.initials: Z
authors.lastname: Bajwa
authors.forename: Linda
authors.initials: L
authors.lastname: Clover
authors.forename: Norbert
authors.initials: N
authors.lastname: Roewer
authors.forename: Robert
authors.initials: R
authors.lastname: Schedel
authors.forename: Helge
authors.initials: H
authors.lastname: Karch
authors.forename: Guenter
authors.initials: G
authors.lastname: Sprotte
authors.forename: Angela
authors.initials: A
authors.lastname: Vincent
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000818:Animals; D001323:Autoantibodies / Q000097:blood* / Q000145:classification; D002167:Campylobacter / Q000276:immunology*; D002169:Campylobacter Infections / Q000276:immunology*; D016009:Chi-Square Distribution; D020918:Complex Regional Pain Syndromes / Q000097:blood / Q000276:immunology* / Q000382:microbiology; D004622:Embryo, Mammalian; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D016014:Linear Models; D008297:Male; D051379:Mice; D008875:Middle Aged; D010525:Peripheral Nerves / Q000378:metabolism / Q000382:microbiology; D012699:Serology / Q000379:methods; D013116:Spinal Cord / Q000378:metabolism / Q000382:microbiology; D013997:Time Factors
chemical_list: D001323:Autoantibodies