[Protective effects of total paeony glycoside against global cerebral ischemia-reperfusion injury in gerbils].
OBJECTIVE
To study the protective effects of the total paeony glycoside (TPG) against global cerebral ischemia-reperfusion injury in gerbils.


METHODS
Gerbils models of global cerebral ischemia-reperfusion injury were prepared by bilateral common carotid artery ligation for 12 min followed by 24-hour reperfusion. The effects of TGP on brain edema index, superoxide dismatase (SOD) activity and malonaldehyde (MDA) concentration of the cerebral tissue homogenate and pathology of the brain were examined 24 h after model establishment.


RESULTS
Compared with the model group, TPG at the doses of 200 and 400 mg/kg could significantly relieve brain edema, enhance SOD activity and lower MDA concentration in the gerbils. Pathological examination showed that the gerbils with TPG treatment had milder injury of the cells in the hippocampal CA1 region.


CONCLUSIONS
TPG has obvious protective effects against global cerebral ischemia-reperfusion injury.
Ma
Ren-Qiang
RQ
School of Pharmaceutical Science, Sun Yat-sen University, Guangzhou 510080, China.
Chen
Jian-Wen
JW
Pang
Jian-Xin
JX
Lan
Xiu-Jian
XJ
Qiu
Can-Hua
CH
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy*; D005849:Gerbillinae; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D008315:Malondialdehyde / Q000378:metabolism; D029596:Paeonia / Q000737:chemistry*; D008517:Phytotherapy; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use; D015427:Reperfusion Injury / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000378:metabolism
D006027:Glycosides; D020011:Protective Agents; D008315:Malondialdehyde; D013482:Superoxide Dismutase