title: Continuous hepatic arterial infusion chemotherapy for liver metastasis from biliary tract and pancreatic cancers.
abstract: BACKGROUND
  The efficacy of intrahepatic arterial chemotherapy for liver metastasis from biliary tract or pancreatic cancer remains uncertain.
  
  
  METHODS
  Five patients with bilio-pancreatic liver metastasis underwent continuous hepatic arterial infusion chemotherapy. One treatment course basically consisted of a 14-day infusion period during which continuous infusions of 5-fluorouracil and intermittent bolus injections of cisplatin were given, and a subsequent 14-day intermission. After two consecutive courses, these drugs were administered bi-weekly.
  
  
  RESULTS
  One complete and three partial responses were observed (response rate, 80%). In responders, the responses persisted until or even after the cessation of chemotherapy. The median survival was 15 months after the start of chemotherapy. The longest survivor has been disease-free for 46 months since a liver tumour remaining despite chemotherapy was eradicated by further treatment. Toxicity was acceptable.
  
  
  CONCLUSIONS
  5-Fluorouracil and cisplatin-based continuous hepatic arterial infusion chemotherapy may serve as a promising treatment for bilio-pancreatic liver metastasis.
authors.affiliation: Department of Surgery, Tokyo Denryoku Hospital, 9-2 Shinanomachi, Shinjuku-ku, Tokyo, 160-0016, Japan. yutarokato@aol.com
authors.forename: Yutaro
authors.initials: Y
authors.lastname: Kato
authors.forename: Akira
authors.initials: A
authors.lastname: Tsuyuki
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Kikuchi
authors.forename: Jo
authors.initials: J
authors.lastname: Tokuyama
authors.forename: Naoto
authors.initials: N
authors.lastname: Kurihara
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kumamoto
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Fujishiro
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Ebinuma
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001661:Biliary Tract Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage; D018572:Disease-Free Survival; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006499:Hepatic Artery / Q000378:metabolism*; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D012008:Recurrence; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin; D005472:Fluorouracil