title: Cerebellar liponeurocytoma: morphological, immunohistochemical, and ultrastructural study of a relapsed case.
abstract: Cerebellar liponeurocytoma is a rare and newly identified neoplasm found in adults which is reputed to be benign. Its salient morphological characteristics are advanced neuronal/neurocytic differentiation, the presence of lipomatous areas, low mitotic rate, and the absence of necrosis, pleomorphism and vascular hyperplasia. Reported is a case of relapsing liponeurocytoma which occurred 3 and a half years after the radical excision of the primary lesion. Histopathological aggressive features (mitoses and a high proliferation index as evaluated by MIB-1) were shown in the primary lesion and recurrence of the tumor. We suggest that liponeurocytoma is an uncertain malignant potential lesion when mitoses are present and the MIB-1 positive cells are more than 10%.
authors.affiliation: Departments of Human Pathology and Oncology, University of Florence, Florence, Italy. ambuccoliero@unifi.it
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Buccoliero
authors.forename: Adele
authors.initials: A
authors.lastname: Caldarella
authors.forename: Stefano
authors.initials: S
authors.lastname: Bacci
authors.forename: Pasquale
authors.initials: P
authors.lastname: Gallina
authors.forename: Antonio
authors.initials: A
authors.lastname: Taddei
authors.forename: Nicola
authors.initials: N
authors.lastname: Di Lorenzo
authors.forename: Paolo
authors.initials: P
authors.lastname: Romagnoli
authors.forename: Gian Luigi
authors.initials: GL
authors.lastname: Taddei
mesh_terms: D002528:Cerebellar Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008527:Medulloblastoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000473:pathology* / Q000601:surgery
chemical_list: D019394:Ki-67 Antigen