title: Preparing for efficacy trials of vaginal microbicides in Indian women.
abstract: Vaginal microbicides are topical compounds that are expected to protect women against vaginal transmission of HIV and other sexually transmitted pathogens. A large number of compounds are being evaluated as possible microbicides. Considering the spread of the HIV epidemic among women in India, clinical trials on microbicides starting from the Phase I safety and acceptability studies to Phase III efficacy trials are important. Conducting efficacy trials is a major endeavour and this review discusses challenges and issues and the preparatory steps to make such efficacy trials possible in India.
authors.affiliation: National AIDS Research Institute, G-73, MIDC, Post Box 1895, Bhosari, Pune 411 026, India. sjoshi@nariindia.org
authors.forename: Smita
authors.initials: S
authors.lastname: Joshi
authors.forename: Suniti
authors.initials: S
authors.lastname: Solomon
authors.forename: Kenneth
authors.initials: K
authors.lastname: Mayer
authors.forename: Sanjay
authors.initials: S
authors.lastname: Mehendale
mesh_terms: D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004992:Ethics, Medical; D005260:Female; D017408:Guidelines as Topic; D006801:Humans; D014621:Vagina
chemical_list: D000891:Anti-Infective Agents, Local