title: Advances in antiviral therapy.
abstract: Infections with five of the herpesviruses (herpes simplex virus 1 [HSV-1], HSV-2, varicella zoster virus, Epstein-Barr virus, and cytomegalovirus) are treated with topical or systemic antiviral therapies. There are more than 100 genotypes of human papillomaviruses (HPVs), which may manifest as warts, skin cancers, cervical cancer, anogenital cancers, and upper digestive tract cancers. Molluscum contagiosum (MC) is a common, benign viral infection of the skin. Immunomodulating agents, such as imiquimod, act on HPV and MC indirectly by inducing host immune responses, such as cytokines and cell-mediated immunity, and thereby reduce recurrences. There are multiple vaccines available for certain viral diseases and others in development for HSV-2 and HPV.
authors.affiliation: Department of Dermatology, University of California at Irvine, 92697-2400, USA.
authors.forename: Jashin J
authors.initials: JJ
authors.lastname: Wu
authors.forename: Katie R
authors.initials: KR
authors.lastname: Pang
authors.forename: David B
authors.initials: DB
authors.lastname: Huang
authors.forename: Stephen K
authors.initials: SK
authors.lastname: Tyring
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D006566:Herpesviridae Infections / Q000188:drug therapy; D006801:Humans; D030361:Papillomavirus Infections / Q000188:drug therapy; D017193:Skin Diseases, Viral / Q000188:drug therapy*; D014765:Viral Vaccines / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D014765:Viral Vaccines