title: What are the reactivities of coronary arteries harvested from the hearts exposed to cold ischemic preservation?
abstract: This study was designed to determine the effects of pretransplant ischemic hypothermic period on reactivities of major coronary arteries. Eleven pigs were used. Right, left anterior descending and circumflex coronary arteries harvested from 6 pigs following single dose of cardioplegia and cardiectomy. The same procedures were performed in 5 pigs after 6 hours static 4 degrees C hypothermic preservation of the hearts. Strips prepared from these 3 coronary arteries were placed in organ chambers and contractions with acetylcholine and histamine and KCL and dilatations with noradrenaline following submaximal contractions with acetylcholine and histamine were documented. There was no statistically significant difference between results taken from both groups. The pretransplant period (until 6 hours) does not cause important differences on the reactivities of coronary arteries.
authors.affiliation: University of Istanbul, Cerrahpaşa Medical Faculty, Turkey. canerkvc@yahoo.com
authors.forename: Caner
authors.initials: C
authors.lastname: Arslan
authors.forename: Sibel
authors.initials: S
authors.lastname: Ozyazgan
authors.forename: Kazim
authors.initials: K
authors.lastname: Beşirli
authors.forename: Emir
authors.initials: E
authors.lastname: Cantürk
authors.forename: Gökçe
authors.initials: G
authors.lastname: Sirin
authors.forename: Kürşat
authors.initials: K
authors.lastname: Bozkurt
authors.forename: Gökhan
authors.initials: G
authors.lastname: Akkan
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D003080:Cold Temperature; D003331:Coronary Vessels / Q000502:physiology*; D016027:Heart Transplantation; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D009926:Organ Preservation; D011189:Potassium Chloride / Q000494:pharmacology; D013552:Swine; D014661:Vasoconstriction / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D014665:Vasodilator Agents; D011189:Potassium Chloride; D006632:Histamine; D000109:Acetylcholine