title: Acute isovolemic anemia impairs central processing as determined by P300 latency.
abstract: OBJECTIVE
  Acute anemia slows the responses to clinical tests of cognitive function. We tested the hypothesis that these slowed responses during acute severe isovolemic anemia in healthy unmedicated humans result from impaired central processing.
  
  
  METHODS
  A blinded operator measured the latency of the P300 peak in nine healthy volunteers at each volunteer's baseline hemoglobin concentration (Hb), and again after isovolemic hemodilution to Hb 5 g/dL. At both Hb concentrations, the P300 latency was measured twice: with the blinded subject breathing air or 100% oxygen, administered in random order.
  
  
  RESULTS
  Anemia increased P300 latency significantly from baseline values (P < 0.05). Breathing oxygen during induced anemia resulted in a P300 latency not different from that at baseline when breathing air (P = 0.5) or oxygen (P = 0.8).
  
  
  CONCLUSIONS
  Impaired central processing is, at least in part, responsible for the slowed responses and deficits of cognitive function that occur during acute isovolemic anemia at Hb 5-6 g/dL.
  
  
  CONCLUSIONS
  The P300 latency appears to be a potential measure of inadequate central oxygenation. In healthy young adults with acute anemia, erythrocytes should be transfused to produce Hb>5-6 g/dL. As a temporizing measure, administration of oxygen can reverse the cognitive deficits and impaired central processing associated with acute anemia.
authors.affiliation: Departments of Anesthesia and Physiology, Cardiovascular Research Institute, University of California, San Francisco, 94143-0648, USA. rbw@itsa.ucsf.edu
authors.forename: Richard B
authors.initials: RB
authors.lastname: Weiskopf
authors.forename: Pearl
authors.initials: P
authors.lastname: Toy
authors.forename: Harriet W
authors.initials: HW
authors.lastname: Hopf
authors.forename: John
authors.initials: J
authors.lastname: Feiner
authors.forename: Heather E
authors.initials: HE
authors.lastname: Finlay
authors.forename: Michelle
authors.initials: M
authors.lastname: Takahashi
authors.forename: Alan
authors.initials: A
authors.lastname: Bostrom
authors.forename: Christopher
authors.initials: C
authors.lastname: Songster
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Aminoff
mesh_terms: D000328:Adult; D000740:Anemia / Q000503:physiopathology* / Q000628:therapy; D001921:Brain / Q000503:physiopathology*; D003071:Cognition / Q000502:physiology*; D017707:Erythrocyte Transfusion; D018913:Event-Related Potentials, P300; D006438:Hemodilution / Q000009:adverse effects*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D010100:Oxygen / Q000097:blood; D010102:Oxygen Inhalation Therapy
chemical_list: D006454:Hemoglobins; D010100:Oxygen