The multitude of targets for the immune system and drug therapy in the fungal cell wall.
Recent studies on fungi revealed that several cytosolic and membrane components migrate to the cell wall together with secreted proteins and biosynthetic polysaccharides to build a dynamic immunoreactive structure. New aspects of fungal cell wall assembly and biosynthesis, focusing on the potential of glycolipids, melanin, heat-shock proteins, histone and surface antigens as targets of drugs and antifungal antibodies are discussed.
Nimrichter
Leonardo
L
Laboratório de Estudos Integrados em Bioquímica Microbiana, Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Cidade Universitária, CCS, Bloco I, Ilha do Fundão, Rio de Janeiro, RJ 21941590, Brazil.
Rodrigues
Marcio L
ML
Rodrigues
Elaine G
EG
Travassos
Luiz R
LR
D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002473:Cell Wall / Q000737:chemistry / Q000187:drug effects / Q000276:immunology; D005656:Fungal Proteins / Q000187:drug effects / Q000276:immunology; D005658:Fungi / Q000187:drug effects* / Q000472:pathogenicity; D006801:Humans; D009181:Mycoses / Q000188:drug therapy* / Q000276:immunology* / Q000382:microbiology
D000935:Antifungal Agents; D005656:Fungal Proteins