title: Occupational allergic contact dermatitis from antioxidant amines in a dental technician.
abstract: We describe an 18-year-old dental technician who presented with dry hyperkeratotic lesions on his left palm that were limited to an area that was in contact with a container in which he had prepared the molds for a dental prosthesis. On patch testing, he had a positive reaction to black rubber mix and its components N-cyclohexyl-N'-phenyl-4-phenylenediamine, N,N'-diphenyl-4-phenylenediamine, and N-isopropyl-N'-phenyl-4-phenylenediamine, as well as to a piece of the rubber container. Thin-layer chromatography (TLC) of a piece of the rubber container confirmed the presence of the para-phenylenediamine mix. Results of patch-testing with TLC were positive after 48 and 96 hours. The lesions resolved when the patient stopped using the container. The patient was diagnosed with occupational allergic contact dermatitis. We also review the dermatoses caused by antioxidant amines.
authors.affiliation: Servicio de Dermatología Laboral, Escuela Nacional de Medicina del Trabajo, Instituto de Salud Carlos III, Cuidad Universitario, Pabellón 8, 28040 Madrid, Spain. lconde@isciii.es
authors.forename: Luis
authors.initials: L
authors.lastname: Conde-Salazar
authors.forename: Ruud
authors.initials: R
authors.lastname: Valks
authors.forename: Carmen García
authors.initials: CG
authors.lastname: Acebes
authors.forename: Josep
authors.initials: J
authors.lastname: Bertó
mesh_terms: D015081:2-Naphthylamine / Q000009:adverse effects* / Q000031:analogs & derivatives*; D000293:Adolescent; D003800:Dental Technicians; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D009783:Dermatitis, Occupational / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D003937:Diagnosis, Differential; D006229:Hand Dermatoses / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008297:Male; D010328:Patch Tests; D010655:Phenylenediamines / Q000009:adverse effects*
chemical_list: D010655:Phenylenediamines; C053264:black rubber; D015081:2-Naphthylamine; C029728:4-phenylenediamine