[HDL-cholesterol--active or passive participant in the pathogenesis of atherosclerosis? (II)].
It is known that high sanguin levels of cholesterol and LDL-cholesterol (LDLc) have an important role in the pathogenesis of atherosclerosis. The treatment of hypercholesterolemia with statins and/or with fibrates have had beneficial effects on coronary heart disease and on other localization of atherosclerosis. The decreased of cholesterol and LDL-cholesterol is the most important effect of this treatment. The epidemiological studies have revealed that the treatment with statins and/or with fibrates produce an increase of HDL-cholesterol (HDLc), which is also very important in the regression of atherosclerosis. We tried in this review to explain the mechanisms of the increase of HDL-cholesterol, in concordance with the data from literature.
Artenie
Anca
A
Spitalul Clinic C.I. Parhon Iaşi, Clinica a IV-a Medicală.
Artenie
R
R
Ungureanu
Didona
D
Botnariu
Gina
G
Anisies
Ecaterina
E
Ionescu
Simona Daniela
SD
Cosovanu
A
A
D000818:Animals; D001161:Arteriosclerosis / Q000097:blood* / Q000209:etiology / Q000517:prevention & control; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000150:complications*; D012307:Risk Factors
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL