title: Predicting enzyme function from protein sequence.
abstract: There are two main reasons to try to predict an enzyme's function from its sequence. The first is to identify the components and thus the functional capabilities of an organism, the second is to create enzymes with specific properties. Genomics, expression analysis, proteomics and metabonomics are largely directed towards understanding how information flows from DNA sequence to protein functions within an organism. This review focuses on information flow in the opposite direction: the applicability of what is being learned from natural enzymes to improve methods for catalyst design.
authors.affiliation: DNA 2.0, 1455 Adams Drive, Menlo Park, CA 94025, USA. minshull@dnatwopointo.com
authors.forename: Jeremy
authors.initials: J
authors.lastname: Minshull
authors.forename: Jon E
authors.initials: JE
authors.lastname: Ness
authors.forename: Claes
authors.initials: C
authors.lastname: Gustafsson
authors.forename: Sridhar
authors.initials: S
authors.lastname: Govindarajan
mesh_terms: D000818:Animals; D004798:Enzymes / Q000737:chemistry*; D006801:Humans; D015202:Protein Engineering; D020539:Sequence Analysis, Protein; D040681:Structural Homology, Protein
chemical_list: D004798:Enzymes