Genetic characterization of rabies virus isolates in Korea.
In investigation of the genetic characteristics of rabies viruses in Korea, the nucleotide and deduced amino acid sequences of the nucleoprotein (N) gene were determined in four Korean rabies virus strains obtained from dogs and raccoons, and were compared with published sequences for non-Korean rabies viruses. Three Korean rabies virus isolates had identical nucleotide sequences, and the fourth differed at only one nucleotide position. The Korean virus isolates had 84.5-92.0% nucleotide sequence similarity and 94.0-99.2% amino acid sequence similarity with non-Korean rabies virus isolates. In a phylogenetic tree based on partial nucleotide sequences of the N gene, the Korean rabies viruses formed a single cluster closely related to Arctic rabies viruses (FXCAN, 9141RUS, and 94260NEP). However, they were divergent from other Asian rabies viruses (94256SRL, 8677MAL, ChiNo.7, Phil 12301, and Mdn1278).
Park
Yoo Jin
YJ
Department of Veterinary Medicine, Kangwon National University, Chunchon 200-701, Republic of Korea.
Shin
Myung Kyun
MK
Kwon
Hyuk Moo
HM
D000818:Animals; D004283:Dog Diseases / Q000821:virology*; D004285:Dogs; D007723:Korea; D008969:Molecular Sequence Data; D009698:Nucleoproteins / Q000235:genetics; D010802:Phylogeny; D011818:Rabies / Q000662:veterinary* / Q000821:virology; D011820:Rabies virus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D011821:Raccoons / Q000821:virology*; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D014764:Viral Proteins / Q000235:genetics
D009698:Nucleoproteins; D014764:Viral Proteins