[Simple methods for evaluating insulin resistance and pancreatic beta-cell function in hypertensive metabolic syndrome].
OBJECTIVE
To investigate whether simple insulin sensitivity indexes and the pancreatic-cell function index of DeltaI(30)/DeltaG(30), and MBCI were suitable to evaluate insulin resistance in metabolic syndrome hypertensives (MS-Hy) as compared with the golden standard clamp technology.


METHODS
According to the results of OGTT, MS-Hy patients were divided into three groups: non glucose tolerant group (NCT), impaired fasting glucose group (IFG) and impaired glucose tolerance grouop (IGT). All subjects were studied with simple insulin sensitivity indexes and pancreatic-cell function index of DeltaI(30)/DeltaG(30) and MBCI.


RESULTS
(1) The results of Cederholm insulin sensitivity index (ISIced) and Defronzo insulin sensitivity index (ISIcom) correlated with those of clamp technology (r = 0.64 and 0.78 respectively, P = 0.0001) in MS-Hy, while the result of HOMA-IR did not correlate with that of clamp technology in such oatuebts. (2) There was no difference of the results of evaluation between isolated-hypertension patients and normal subjects aside from the level of blood pressure. (3) The rate of IR in MS-Hy patients was 69.10% obtained from clamp technologyhose from ISIced and ISIcom were 76.37% and 52.13% respectively. (4) Insulin release test in MS-Hy patients showed that the highest peak release of insulin was postponed by 60 minutes.


CONCLUSIONS
(1) The results of ISIced and ISIcom obtained from OGTT data were suitable to evaluate IR in MS-Hy patients and ISIced was the better of the two, while HOMA-IR was not suitable. (2) As compared with isolated-hypertension group, MS-NGT group showed higher insulin release. (3) MBCI was more suitable for evaluation of IR than I(30)/G(30) in MS-Hy.
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D015309:Glucose Clamp Technique; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D007333:Insulin Resistance; D007515:Islets of Langerhans / Q000502:physiology*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000503:physiopathology*; D008875:Middle Aged
D001786:Blood Glucose