[Clinical study of zhuyutongmai capsule on treating senile cerebral infarction and effect on function of vascular endothelium].
OBJECTIVE
To evaluate the clinical study of Zhuyutongmai (ZYTM) Capsule in treating senile cerebral infarction and effect on function of vascular endothelium.


METHODS
Sixty-four aged patients with cerebral infarction were randomly divided into the treated group treated with ZYTM and the control group treaded with Naoluotong. The clinical effect was observed. The hemorrheologic and hemodynamic parameters, the blood levels of endothelin (ET) and nitric oxide (NO) were determined before and after treatment.


RESULTS
After treatment of ZYTM, the hemorrheologic and hemodynamic parameters were all significantly improved (P < 0.01 or P < 0.05), the therapeutic effect of ZYTM was better than that of Naoluotong (P < 0.05), compared with the control group after treatment, the level of ET in the treated group were lower (P < 0.01), and level of NO were higher (P < 0.01).


CONCLUSIONS
ZYTM has good effect in treating senile cerebral infarction.
Liu
Hongjian
H
Department of Chinese Medicine, the First Affiliated Hospital of Zhongshan University, Guangzhou.
Wu
Xinlin
X
Wu
Guozhen
G
D000368:Aged; D001809:Blood Viscosity / Q000187:drug effects; D002214:Capsules; D002544:Cerebral Infarction / Q000188:drug therapy* / Q000503:physiopathology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy
D002214:Capsules; D004365:Drugs, Chinese Herbal