title: Radiotherapy and chemotherapy for myoepithelioma of the sellar region.
abstract: BACKGROUND
  Myoepithelioma might arise in the head and neck area, especially within the salivary glands. It is very uncommon as a primary intracranial tumor.
  
  
  METHODS
  A 34-year-old African patient with proliferating myoepithelioma originating in the sellar region is described. After subtotal resection, the tumor recurred locally despite postoperative radiotherapy to a total dose of 54 Gy (Figures 1 and 2). When intracranial metastases developed, chemotherapy with ifosfamide and, later, BCNU was administered. No objective response was obtained with any of the nonsurgical approaches. Uncontrolled intracranial tumor growth led to the patient's death 20 months after the initial diagnosis.
  
  
  CONCLUSIONS
  Most tumors of the sellar region have a favorable prognosis. However, this case of incompletely resected proliferating myoepithelioma showed both local and distant recurrences, which did not respond to further treatment. Thus, complete surgical resection is recommended, whenever technically feasible.
authors.affiliation: Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Germany. cnied@hotmail.com
authors.forename: Carsten
authors.initials: C
authors.lastname: Nieder
authors.forename: Folker
authors.initials: F
authors.lastname: Schneller
authors.forename: Anca L
authors.initials: AL
authors.lastname: Grosu
authors.forename: Christian
authors.initials: C
authors.lastname: Peschel
authors.forename: Michael
authors.initials: M
authors.lastname: Molls
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D009208:Myoepithelioma / Q000188:drug therapy* / Q000532:radiotherapy*; D010166:Palliative Care; D011379:Prognosis; D011859:Radiography; D012658:Sella Turcica / Q000000981:diagnostic imaging*