Inhibitory effect of jaceosidin isolated from Artemisiaargyi on the function of E6 and E7 oncoproteins of HPV 16.
Jaceosidin (4',5,7-trihydroxy-3',6-dimethoxyflavone) was isolated from Artemisia argyi as a putative oncogene inhibitor. Jaceosidin inhibited binding between oncoprotein E6 of the human papillomavirus and the p53 tumor suppressor protein. In addition, jaceosidin inhibited binding between the E7 oncoprotein and the Rb tumor suppressor protein, and also inhibited the function of HPV-16 harboring cervical cancer cells, including SiHa and CaSki. Collectively, jaceosidin inhibited the functions of the E6 and E7 oncoproteins of the human papillomavirus, suggesting that this compound might be used as a potential drug for the treatment of cervical cancers associated with the human papillomavirus.
Lee
Hee-Gu
HG
Laboratory of Cell Biology, Korea Research Institute of Bioscience and Biotechnology, Yuseong P.O. Box 115, Daejeon 305-600, Korea.
Yu
Kyung-Ae
KA
Oh
Won-Keun
WK
Baeg
Tae-Woong
TW
Oh
Hyun-Cheol
HC
Ahn
Jong-Seog
JS
Jang
Won-Cheoul
WC
Kim
Jong-Wan
JW
Lim
Jong-Seok
JS
Choe
Yong-Kyung
YK
Yoon
Do-Young
DY
D019306:Artemisia; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009856:Oncogene Proteins, Viral / Q000187:drug effects* / Q000378:metabolism; D050725:Papillomavirus E7 Proteins; D018515:Plant Leaves; D012097:Repressor Proteins / Q000187:drug effects* / Q000378:metabolism; D014407:Tumor Cells, Cultured / Q000187:drug effects*; D002583:Uterine Cervical Neoplasms
C068651:E6 protein, Human papillomavirus type 16; D005419:Flavonoids; D009856:Oncogene Proteins, Viral; D050725:Papillomavirus E7 Proteins; D012097:Repressor Proteins; C059731:oncogene protein E7, Human papillomavirus type 16; C477508:jaceosidin