title: [Molecular mechanisms of macroevolution].
abstract: The present paper is devoted to the evolutionary role of genetic modules shuffing. The mechanisms capable to produce new molecular functions and significant complications of ontogenesis are reviewed. Two-step model of macroevolution is proposed. This model comprises: (1) Arising of a new combination of genetic modules. This step does not result in formation of a new taxon but makes necessary ground for that process. (2) Precise structure completing of the new combination of modules and corresponding genome optimization by use of various mechanisms including point mutations. This step concerns many genes and finally leads to formation of a new taxon. It is shown that arising of new combinations of genetic modules might work out as molecular basis for progressive evolution, while alternative structural completing of the same combination might result in adaptive radiation.
authors.forename: O N
authors.initials: ON
authors.lastname: Tikhodeev
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics; D000818:Animals; D019143:Evolution, Molecular; D005091:Exons; D008958:Models, Molecular; D046912:Multiprotein Complexes / Q000737:chemistry / Q000235:genetics*; D010944:Plants; D017354:Point Mutation; D011401:Promoter Regions, Genetic; D011487:Protein Conformation; D011995:Recombination, Genetic
chemical_list: D046912:Multiprotein Complexes