Long-lasting CD3+ T-cell deficiency after cord blood stem cell transplantation in a human herpesvirus 6-infected child.
We report a long-lasting (8-month) reactivation of human herpesvirus 6 (HHV-6) infection in child who had undergone cord blood stem cell transplantation. The reactivation was characterized by high viral loads and by immediate-early mRNA positivity. HHV-6 infection was associated with a deep depletion of CD3, while the CD4/CD8 ratio remained substantially unchanged.
Comar
Manola
M
Department of Public Medicine Sciences, University of Trieste, Trieste, Italy.
D'Agaro
Pierlanfranco
P
Horejsh
Douglas
D
Galvan
Monica
M
Fiorentini
Simona
S
Andolina
Marino
M
Caruso
Arnaldo
A
Di Luca
Dario
D
Campello
Cesare
C
D017252:CD3 Complex / Q000378:metabolism*; D016516:CD4-CD8 Ratio; D002648:Child; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects*; D015654:Herpesvirus 6, Human / Q000502:physiology*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000209:etiology*; D008297:Male; D019349:Roseolovirus Infections / Q000209:etiology* / Q000821:virology; D013601:T-Lymphocytes / Q000166:cytology*; D014775:Virus Activation
D017252:CD3 Complex