title: Sensitivity of different zygomycetes to the Penicillium chrysogenum antifungal protein (PAF).
abstract: The effects of the Penicillium. chrysogenum low molecular mass antifungal protein (PAF) on selected fungal species belonging in the Zygomycetes were investigated. A total of 21 fungal isolates from 15 different genera (Absidia, Actinomucor, Cokeromyces, Gilbertella, Micromucor, Mortierella, Mucor, Mycotypha, Rhizomucor, Rhizopus, Saksenaea, Syncephalastrum, Thamnostylum, Umbelopsis and Zygorhynchus) were tested. The inhibitory potentials of PAF at 50 microg ml(-1) on the germination of the sporangiospores and at 6.25-50 microg ml(-1) on the hyphal extension were examined on different culture media. From among the fungi regarded as opportunistic human and/or animal pathogens, PAF exhibited inhibitory effects against Absidia, Mortierella, Rhizomucor and Rhizopus species.
authors.affiliation: Department of Microbiology, Faculty of Sciences, University of Szeged, P.O. Box 533, H-6701, Szeged, Hungary. galgoczi@vnet.hu
authors.forename: László
authors.initials: L
authors.lastname: Galgóczy
authors.forename: Tamás
authors.initials: T
authors.lastname: Papp
authors.forename: Eva
authors.initials: E
authors.lastname: Leiter
authors.forename: Florentine
authors.initials: F
authors.lastname: Marx
authors.forename: István
authors.initials: I
authors.lastname: Pócsi
authors.forename: Csaba
authors.initials: C
authors.lastname: Vágvölgyi
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D005656:Fungal Proteins / Q000302:isolation & purification / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D025301:Hyphae / Q000187:drug effects / Q000254:growth & development; D010407:Penicillium; D010408:Penicillium chrysogenum / Q000737:chemistry*; D013172:Spores, Fungal / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D005656:Fungal Proteins; C097832:PAF protein, Penicillium chrysogenum