title: Effect of different immunosuppressive therapies on the lipid pattern in kidney-transplanted rats.
abstract: We analyzed the effect of oral administration of cyclosporine-methylprednisone (CsA-MP) and sirolimus (SRL) on the lipid pattern of kidney-transplanted rats after a 7-day survival. A significant increase in plasma cholesterol in CsA-MP group (control: 26 +/- 3 mg/dl vs. 59 +/- 8 mg/dl, P < 0.05) and in triglyceride levels in SRL group (control: 53 +/- 4 mg/dl vs. 114 +/- 3 mg/dl, P < 0.05), was shown. Kidney microsomal membranes from both treated groups showed that cholesterol and triglyceride values and the relative percentage of arachidonic acid in the total amount of n-6 fatty acids decreased. A diminution of linoleic acid occurred in testis (control: 9.4 +/- 0.1 mg/dl vs. CsA-MP: 6.0 +/- 0.3 mg/dl and vs. SRL: 6.8 +/- 0.2 mg/dl, P < 0.05), liver (control: 17.7 +/- 0.6 mg/dl vs. CsA-MP: 15.1 +/- 0.6 mg/dl and SRL: 13.5 +/- 0.8 mg/dl, P < 0.05) and erythrocyte membranes (control:11.7 +/- 0.1% vs. CsA-MP: 10.6 +/- 0.2% and SRL: 10.0 +/- 0.4%, P < 0.01). The immunosuppressive therapies improved the rejection rate of the graft, fact that was remarkable in the SRL-treated group. However, lipid abnormalities still remain in spite of immunosuppressive therapies (150).
authors.affiliation: Laboratorio de Trasplante de Organos, Facultad de Ciencias Médicas, Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP-CONICET-UNLP), Universidad Nacional de La Plata, La Plata, Argentina. nlausada@atlas.med.unlp.edu.ar
authors.forename: Natalia
authors.initials: N
authors.lastname: Lausada
authors.forename: T
authors.initials: T
authors.lastname: de Gómez Dumm Nelva
authors.forename: Luna
authors.initials: L
authors.lastname: Georgina
authors.forename: Camihort
authors.initials: C
authors.lastname: Gisela
authors.forename: Raimondi
authors.initials: R
authors.lastname: Clemente
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000633:toxicity; D004910:Erythrocyte Membrane / Q000378:metabolism; D006949:Hyperlipidemias / Q000139:chemically induced; D007166:Immunosuppressive Agents / Q000633:toxicity*; D007668:Kidney / Q000378:metabolism; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology / Q000502:physiology*; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D008775:Methylprednisolone / Q000633:toxicity; D008862:Microsomes, Liver / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D020123:Sirolimus / Q000633:toxicity; D013737:Testis / Q000378:metabolism; D014280:Triglycerides / Q000097:blood; D014508:Urea / Q000097:blood
chemical_list: D007166:Immunosuppressive Agents; D008055:Lipids; D008563:Membrane Lipids; D014280:Triglycerides; D016572:Cyclosporine; D014508:Urea; D002784:Cholesterol; D003404:Creatinine; D020123:Sirolimus; D008775:Methylprednisolone