title: [Review and categorization of quinolone antibiotics].
abstract: No standard categorization of quinolone antibiotics into generations may be found in either Czech or world literature. The author recommends a categorization into four groups defined according to their spectrum of action and utilization: 1) preparations for the treatment of urinary tract infections; 2) systemically acting quinolones chiefly efficacious against Gram-negative bacteria; 3) so-called respiratory quinolones; and 4) quinolones with a very broad spectrum of action suitable for the treatment of very complicated infections. The author describes the chief characteristics of the most important quinolone antibiotics, including preparations either in their development stage or whose development has been prematurely interrupted because of adverse side-effects. The list includes all preparations that are or were temporarily registered in the Czech Republic.
authors.affiliation: Department of Infectious Diseases, 3rd Medical Faculty, Charles University Prague, Hospital na Bulovce, Prague, Czech Republic. benesj@cesnet.cz
authors.forename: Jirí
authors.initials: J
authors.lastname: Benes
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000145:classification / Q000627:therapeutic use; D006801:Humans; D015363:Quinolones / Q000737:chemistry / Q000145:classification / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D015363:Quinolones