title: Genomic studies of mood disorders -- the brain as a muscle?
abstract: Recent genomic studies showing abnormalities in the fibroblast growth factor system in the postmortem brains of people with major depressive disorder support previous indications of a role for growth factors in mood disorders. Similar molecular pathways, volumetric changes, and the effects of exercise on mood suggest a superficial analogy, and perhaps a deeper relationship, between muscle and brain functioning.
authors.affiliation: Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202-4887, USA. anicules@iupui.edu
authors.forename: Alexander B
authors.initials: AB
authors.lastname: Niculescu
mesh_terms: D005075:Biological Evolution; D001921:Brain / Q000378:metabolism*; D023281:Genomics; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D019964:Mood Disorders / Q000235:genetics*; D009132:Muscles / Q000378:metabolism*
chemical_list: D006133:Growth Substances