title: Time-course of sTREM (soluble triggering receptor expressed on myeloid cells)-1, procalcitonin, and C-reactive protein plasma concentrations during sepsis.
abstract: OBJECTIVE
  To describe the course of plasma sTREM (soluble triggering receptor expressed on myeloid cells)-1, procalcitonin (PCT), and C-reactive protein (CRP) concentrations during sepsis and their clinical informative value in predicting outcome.
  
  
  METHODS
  Prospective, noninterventional study.
  
  
  METHODS
  Medical adult intensive care unit at a university hospital in France.
  
  
  METHODS
  Sixty-three critically ill patients with sepsis, severe sepsis, or septic shock.
  
  
  METHODS
  None.
  
  
  RESULTS
  Soluble TREM-1 concentrations were significantly lower at admission in nonsurvivors (n = 21) than in survivors (n = 42) (94 [30-258] vs. 154 [52-435] pg/mL, p = .02), whereas PCT levels were higher among nonsurvivors (19.2 [0.3-179] vs. 2.4 (0-254) pg/mL, p = .001). CRP levels did not differ between the two groups of patients. Plasma PCT and CRP decreased during the 14-day period of study in both survivors and nonsurvivors. Conversely, sTREM-1 plasma concentrations remained stable or even increased in nonsurviving patients and decreased in survivors. An elevated baseline sTREM-1 level was found to be an independent protective factor with an odds of dying of 0.1 (95% confidence interval, 0.1-0.8).
  
  
  CONCLUSIONS
  A progressive decline of plasma sTREM-1 concentration indicates a favorable clinical evolution during the recovery phase of sepsis. In addition, baseline sTREM-1 level may prove useful in predicting outcome of septic patients.
authors.affiliation: Service de Réanimation Médicale, Hôpital Central, Nancy, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Gibot
authors.forename: Aurélie
authors.initials: A
authors.lastname: Cravoisy
authors.forename: Marie-Nathalie
authors.initials: MN
authors.lastname: Kolopp-Sarda
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Béné
authors.forename: Gilbert
authors.initials: G
authors.lastname: Faure
authors.forename: Pierre-Edouard
authors.initials: PE
authors.lastname: Bollaert
authors.forename: Bruno
authors.initials: B
authors.lastname: Levy
mesh_terms: D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011498:Protein Precursors / Q000097:blood*; D011971:Receptors, Immunologic / Q000097:blood*; D018805:Sepsis / Q000097:blood* / Q000276:immunology*; D016019:Survival Analysis; D013997:Time Factors; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D008562:Membrane Glycoproteins; D011498:Protein Precursors; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide