title: Salicylic acid and PEG-contained polyanhydrides: synthesis, characterization, and in vitro salicylic acid release.
abstract: Poly [bi(o-carboxyphenyl)adipate-polyethylene glycol] anhydrides--P(BOCA-PEG)--polymeric drugs were synthesized and characterized by Fourier transformed infrared spectroscopy, NMR, DSC, gel permeation chromatography, etc. Salicylic acid loading efficiency of these polymers ranged from 43.5% to 71.3%, which was much higher than that of other polymeric drugs with salicylic acid. The in vitro release of salicylic acid from the polymers was carried out in buffer conditions with different pH values and and rat gastrointestinal contents. The results showed the release rate of salicylic acid increased with the increase of PEG content in the polymers and the increase of pH value of degradation buffer solution. The rat cecal contents also greatly promoted the release of salicylic acid. In 0.1M phosphate buffer solution at pH8.0, 37 degrees C containing 5% rat cecal contents, P(BOCA-PEG200)(80:20) had 15% salicylic acid released in 21 hr, indicating its potential use in colon-specific salicylic acid delivery.
authors.affiliation: Institute of Polymer Science, Zhejiang University, Hangzhou 310-027, P. R. China.
authors.forename: Qixiang
authors.initials: Q
authors.lastname: Cai
authors.forename: K J
authors.initials: KJ
authors.lastname: Zhu
authors.forename: Jianxiang
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000818:Animals; D049388:Polyanhydrides / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D020156:Salicylic Acid / Q000138:chemical synthesis* / Q000493:pharmacokinetics
chemical_list: D049388:Polyanhydrides; D011092:Polyethylene Glycols; D020156:Salicylic Acid