title: Steroid-induced osteonecrosis in refractory ulcerative colitis.
abstract: We report a case of steroid-induced osteonecrosis in a patient with refractory ulcerative colitis. A 31 year-old woman presented suffering from refractory ulcerative colitis. She had been treated by prednisolone for ten years. Sharp pain and swelling appeared suddenly in her right knee. Conventional radiography revealed neither osteoporosis nor a fracture. However, magnetic resonance imaging by T1-, T2 and T2*-weighted images revealed irregular heterogeneous areas of low- and high-intensity in her right femur and tibia. For a precise early diagnosis of osteonecrosis, bone magnetic resonance imaging was found to be an excellent diagnostic tool.
authors.affiliation: Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Ito
authors.forename: Mieko
authors.initials: M
authors.lastname: Inuo-Nakayama
authors.forename: Masahiro
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Masaru
authors.initials: M
authors.lastname: Kubokawa
authors.forename: Yojiro
authors.initials: Y
authors.lastname: Sadamoto
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kubo
authors.forename: Munehiro
authors.initials: M
authors.lastname: Tanaka
authors.forename: Naohiko
authors.initials: N
authors.lastname: Harada
authors.forename: Kiyoyuki
authors.initials: K
authors.lastname: Torigoshi
authors.forename: Masakazu
authors.initials: M
authors.lastname: Hirakawa
authors.forename: Hajime
authors.initials: H
authors.lastname: Nawata
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D010020:Osteonecrosis / Q000175:diagnosis / Q000188:drug therapy*; D011239:Prednisolone / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone