Covalent attachment of an NLS-peptide to linear dna does not enhance transfection efficiency of cationic polymer based gene delivery systems.
van der Aa
M
M
Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, P.O Box 80082, 3508 TB Utrecht, The Netherlands.
Koning
G
G
van der Gugten
J
J
d'Oliveira
C
C
Oosting
R
R
Hennink
W E
WE
Crommelin
D J A
DJ
D000818:Animals; D019556:COS Cells; D004247:DNA / Q000008:administration & dosage*; D018014:Gene Transfer Techniques; D008689:Methacrylates / Q000008:administration & dosage*; D051379:Mice; D041681:NIH 3T3 Cells; D019913:Nuclear Localization Signals / Q000008:administration & dosage*; D009757:Nylons; D012710:Serum Albumin, Bovine / Q000008:administration & dosage / Q000493:pharmacokinetics; D014162:Transfection
D008689:Methacrylates; D019913:Nuclear Localization Signals; D009757:Nylons; C407037:poly(2-(dimethylamino)ethyl methacrylate); D012710:Serum Albumin, Bovine; D004247:DNA