Programmable DNA self-assemblies for nanoscale organization of ligands and proteins.
We demonstrate the precise control of periodic spacing between individual protein molecules by programming the self-assembly of DNA tile templates. In particular, we report the application of two self-assembled periodic DNA structures, two-dimensional nanogrids, and one-dimensional nanotrack, as template for programmable self-assembly of streptavidin protein arrays with controlled density.
Park
Sung Ha
SH
Department of Computer Science, Duke University, Durham, North Carolina 27708, USA.
Yin
Peng
P
Liu
Yan
Y
Reif
John H
JH
LaBean
Thomas H
TH
Yan
Hao
H
D004247:DNA / Q000737:chemistry* / Q000648:ultrastructure*; D008024:Ligands; D018625:Microscopy, Atomic Force; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D011506:Proteins / Q000737:chemistry*; D013698:Templates, Genetic
D008024:Ligands; D011506:Proteins; D004247:DNA