title: High central venous pressure is associated with prolonged mechanical ventilation and increased mortality after lung transplantation.
abstract: BACKGROUND
  Poor oxygenation might occur in transplanted lungs as a result of reperfusion injury and lack of lymphatic drainage. Low central venous and pulmonary capillary wedge pressures are advocated to reduce pulmonary edema and maximize oxygenation but might adversely affect cardiac index, circulation, and renal function.
  
  
  METHODS
  Histories, intensive care unit charts, and donor data on 118 lung transplantations performed between 1999 and 2002 were retrospectively assessed. Multiple logistic regression analysis was performed on donor, recipient, operative, and intensive care unit parameters to determine the relationship of filling pressure (central venous and pulmonary capillary wedge pressures) to prolonged mechanical ventilation and outcome. The mean central venous pressure was used to divide patients into high and low central venous pressure groups, which were then compared to determine differences in outcome and complication rates.
  
  
  RESULTS
  A high central venous pressure was found to be associated with prolonged mechanical ventilation (odds ratio, 1.57; 95% confidence interval, 1.13-2.20; P = .008). After removing the effect of poor myocardial function by excluding patients with low cardiac index (< 2.2 L x min -1 x m(-2) ) and high inotrope requirement (> 10 microg/min), central venous pressure remained associated with prolonged mechanical ventilation (odds ratio, 2.31; 95% confidence interval, 1.31-4.07; P = .004). Duration of ventilation (P < .001), intensive care unit mortality (P = .02), hospital mortality (P = .09), and 2-month mortality (P = .02) were higher in patients with central venous pressures of greater than 7 mm Hg. There was no evidence of complications caused by hypovolemia in the low (< or = 7 mm Hg) central venous pressure group, who had lower inotrope requirements (P = .02) and lower creatinine levels (P = .013). Conclusions A high central venous pressure was associated with adverse outcomes after lung transplantation.
authors.affiliation: Department of Intensive Care Medicine, The Alfred Hospital, Prahran, Australia.
authors.forename: D V
authors.initials: DV
authors.lastname: Pilcher
authors.forename: C D
authors.initials: CD
authors.lastname: Scheinkestel
authors.forename: G I
authors.initials: GI
authors.lastname: Snell
authors.forename: A
authors.initials: A
authors.lastname: Davey-Quinn
authors.forename: M J
authors.initials: MJ
authors.lastname: Bailey
authors.forename: T J
authors.initials: TJ
authors.lastname: Williams
mesh_terms: D000328:Adult; D002316:Cardiotonic Agents / Q000627:therapeutic use; D002496:Central Venous Pressure / Q000502:physiology*; D003404:Creatinine / Q000032:analysis; D003422:Critical Care; D005260:Female; D006801:Humans; D016040:Lung Transplantation; D008196:Lymph / Q000502:physiology; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology; D011183:Postoperative Complications; D011669:Pulmonary Wedge Pressure / Q000502:physiology; D015427:Reperfusion Injury / Q000150:complications; D012121:Respiration, Artificial; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors; D014019:Tissue Donors; D016896:Treatment Outcome
chemical_list: D002316:Cardiotonic Agents; D003404:Creatinine