Surgery and treatment with high-dose liposomal amphotericin B for eradication of craniofacial zygomycosis in a patient with Hodgkin's disease who had undergone allogeneic hematopoietic stem cell transplantation.
This case report describes craniofacial zygomycosis in a 24-year-old male with Hodgkin's disease who underwent chemotherapy and autologous hematopoietic stem cell transplantation, followed by a nonmyeloablative allogeneic transplant. Empirical therapy with itraconazole and amoxicillin-clavulanate failed to resolve the infection. Postdiagnosis, surgery and treatment with high-dose liposomal amphotericin B eradicated the disease.
Barron
Michelle A
MA
University of Colorado Health Sciences Center, 4200 E. Ninth Avenue, Box 168, Denver, CO 80262, USA. Michelle.Barron@UCHSC.edu
Lay
Margaret
M
Madinger
Nancy E
NE
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D005157:Facial Pain / Q000209:etiology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006689:Hodgkin Disease / Q000628:therapy; D006801:Humans; D008081:Liposomes / Q000627:therapeutic use; D008297:Male; D009091:Mucormycosis / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery; D012233:Rhizopus / Q000145:classification / Q000302:isolation & purification; D012852:Sinusitis / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery; D014184:Transplantation, Homologous / Q000009:adverse effects*
D000935:Antifungal Agents; D008081:Liposomes; C068538:liposomal amphotericin B; D000666:Amphotericin B