title: Design, synthesis and biological evaluation of novel, simplified analogues of laulimalide: modification of the side chain.
abstract: Novel, simplified analogues of the microtubule-stabilizing anticancer agent laulimalide, including the first derivatives with unnatural side chains, were designed by molecular modelling, synthesized by a late-stage diversification strategy, and evaluated in vitro for growth inhibition of human ovarian carcinoma cell lines (A2780, A2780/AD10).
authors.affiliation: University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK, EU. ip100@cam.ac.uk
authors.forename: Ian
authors.initials: I
authors.lastname: Paterson
authors.forename: Dirk
authors.initials: D
authors.lastname: Menche
authors.forename: Anders E
authors.initials: AE
authors.lastname: Håkansson
authors.forename: Adrian
authors.initials: A
authors.lastname: Longstaff
authors.forename: David
authors.initials: D
authors.lastname: Wong
authors.forename: Isabel
authors.initials: I
authors.lastname: Barasoain
authors.forename: Rubén M
authors.initials: RM
authors.lastname: Buey
authors.forename: J Fernando
authors.initials: JF
authors.lastname: Díaz
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects*; D045744:Cell Line, Tumor; D015195:Drug Design; D005260:Female; D006801:Humans; D018942:Macrolides; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D010051:Ovarian Neoplasms; D013329:Structure-Activity Relationship; D043823:Taxoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D018942:Macrolides; D043823:Taxoids; C117305:laulimalide