Intrinsic epileptogenicity in polymicrogyric cortex suggested by EEG-fMRI BOLD responses.
Polymicrogyria (PMG) is a widespread cortical malformation frequently associated with seizures and EEG spikes. Its epileptogenicity is poorly understood. Nine patients with simultaneous EEG and fMRI were studied to assess the blood oxygenation level-dependent response to spikes. Sixteen of 18 studies showed responses, with maximum activation involving the lesion in 61.5%, but often limited to a small fraction of that lesion, suggesting intrinsic epileptogenicity in small areas of the PMG cortex.
Kobayashi
E
E
Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada. eliane.kobayashi@mail.mcgill.ca
Bagshaw
A P
AP
Jansen
A
A
Andermann
F
F
Andermann
E
E
Gotman
J
J
Dubeau
F
F
D000200:Action Potentials / Q000502:physiology; D000328:Adult; D001931:Brain Mapping / Q000379:methods; D002540:Cerebral Cortex / Q000002:abnormalities* / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D004569:Electroencephalography / Q000379:methods* / Q000639:trends; D004827:Epilepsy / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000639:trends; D008297:Male; D009421:Nervous System Malformations / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*; D009434:Neural Pathways / Q000002:abnormalities / Q000503:physiopathology; D009474:Neurons / Q000502:physiology; D011237:Predictive Value of Tests