[Establishment of a modified canine model of acute cardiac insufficiency].
OBJECTIVE
To establish a canine model of acute cardiac insufficiency (ACI) by coronary artery occlusion and right ventricular pacing.


METHODS
Twelve dogs were subjected to rapid ventricular pacing after ligation of the left anterior descending coronary artery (LAD), to induce the cardiac output (CO) to reduce by 25%; and 50%; from the basal level. The arterial pressure (AP), arterial oxygen saturation (SaO(2)), mean right atrial pressure (mRAP), mean pulmonary capillary wedge pressure (mPCWP), and systemic vascular resistance (SVR) were measured in the dogs according to different CO conditions. Echocardiography was used to measure the cardiac size and left ventricular ejection fraction (LVEF).


RESULTS
CO was decreased by 25%; and 50%; steadily from the basal level after right ventricular pacing following ligation of the LAD. AP and SaO(2) decreased while mRAP, mPCWP, and SVR increased significantly following CO reduction. The cardiac cavity became larger while LVEF decreased after CO was decreased by 25% and 50%.


CONCLUSIONS
Canine model of ACI can be successfully established by right ventricular pacing following ligation of the LAD.
Xie
Jin-Guo
JG
Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. xajngo@fimmu.com
Ou
Wen-Chao
WC
Xiu
Zheng-Cheng
ZC
Zeng
Ping
P
Liu
Yi-Li
YL
D000818:Animals; D002303:Cardiac Output, Low / Q000209:etiology; D002304:Cardiac Pacing, Artificial; D003331:Coronary Vessels; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D008026:Ligation; D008297:Male