title: [Nifekalant hydrochloride as an effective treatment for postoperative ischemic heart disease].
abstract: We experienced 2 effective cases of nifekalant hydrochloride. One patient was 76-year-old female who underwent emergent coronary artery bypass grafting (CABG) because of unstable angina pectoris (AP) and ventricular fibrillation (Vf). Her cardiac function had been decreased preoperatively due to old myocardial infarction (OMI). One day after CABG, she revealed sustained ventricular tachycardia (VT) and Vf. Although administrations of neither lidocaine hydrochloride nor magnesium sulfate were effective, nifekalant hydrochloride finally stopped the life-threatening arrhythmia without hypotension. Another patient was 77-year-old male who underwent CABG and Dor operation. His cardiac function also had been decreased due to OMI. He revealed VT attack at midnight 3 days after operation. VT attack still appeared at next 2 midnight under lidocaine hydrochloride infusion, but finally it has disappeared after starting a drip infusion of nifekalant hydrochloride. Nifekalant hydrochloride is quite useful as a new therapeutic strategy for uncontrollable VT and Vf and for the patient who has a reduced left ventricular function because it has an inotropic effect.
authors.affiliation: Department of Surgery, Cardiovascular Institute Hospital, Tokyo, Japan.
authors.forename: Yoshihara
authors.initials: Y
authors.lastname: Enomoto
authors.forename: K
authors.initials: K
authors.lastname: Aoki
authors.forename: Y
authors.initials: Y
authors.lastname: Toshimitsu
authors.forename: Y
authors.initials: Y
authors.lastname: Inai
authors.forename: T
authors.initials: T
authors.lastname: Asakura
authors.forename: S
authors.initials: S
authors.lastname: Furuta
mesh_terms: D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D017202:Myocardial Ischemia / Q000601:surgery*; D011183:Postoperative Complications / Q000188:drug therapy*; D011744:Pyrimidinones / Q000627:therapeutic use*; D017180:Tachycardia, Ventricular / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000889:Anti-Arrhythmia Agents; D011744:Pyrimidinones; C076259:nifekalant