Panel of prototypical infectious molecular HIV-1 clones containing multiple nucleoside reverse transcriptase inhibitor resistance mutations.
We have created a panel of recombinant HIV-1 infectious clones containing common patterns of reverse transcriptase (RT) mutations responsible for resistance to each of the currently available nucleoside reverse transcriptase inhibitors (NRTI), and we have submitted the panel to the National Institutes of Health AIDS Research and Reference Reagent Programme. Testing the activity of new antiretroviral compounds against this panel of drug-resistant clones will determine their relative activity against many clinically relevant NRTI-resistant viruses.
Johnston
Elizabeth
E
Division of Infectious Diseases, Stanford University, Stanford, CA, USA.
Dupnik
Kathryn M
KM
Gonzales
Matthew J
MJ
Winters
Mark A
MA
Rhee
Soo-Yon
SY
Imamichi
Tomozumi
T
Shafer
Robert W
RW
D002999:Clone Cells; D024921:Drug Resistance, Multiple, Viral / Q000235:genetics; D005838:Genotype; D015658:HIV Infections / Q000821:virology*; D054303:HIV Reverse Transcriptase / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics* / Q000302:isolation & purification*; D006801:Humans; D009154:Mutation; D012367:RNA, Viral / Q000302:isolation & purification; D018894:Reverse Transcriptase Inhibitors; D014776:Virus Cultivation
D012367:RNA, Viral; D018894:Reverse Transcriptase Inhibitors; D054303:HIV Reverse Transcriptase