title: Programmable DNA self-assemblies for nanoscale organization of ligands and proteins.
abstract: We demonstrate the precise control of periodic spacing between individual protein molecules by programming the self-assembly of DNA tile templates. In particular, we report the application of two self-assembled periodic DNA structures, two-dimensional nanogrids, and one-dimensional nanotrack, as template for programmable self-assembly of streptavidin protein arrays with controlled density.
authors.affiliation: Department of Computer Science, Duke University, Durham, North Carolina 27708, USA.
authors.forename: Sung Ha
authors.initials: SH
authors.lastname: Park
authors.forename: Peng
authors.initials: P
authors.lastname: Yin
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: John H
authors.initials: JH
authors.lastname: Reif
authors.forename: Thomas H
authors.initials: TH
authors.lastname: LaBean
authors.forename: Hao
authors.initials: H
authors.lastname: Yan
mesh_terms: D004247:DNA / Q000737:chemistry* / Q000648:ultrastructure*; D008024:Ligands; D018625:Microscopy, Atomic Force; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D011506:Proteins / Q000737:chemistry*; D013698:Templates, Genetic
chemical_list: D008024:Ligands; D011506:Proteins; D004247:DNA