Mucosal vaccination with an attenuated maedi-visna virus clone.
Four sheep were infected intratracheally with an attenuated molecular clone of maedi-visna virus (MVV). All four became infected. Ten months later these sheep were challenged intratracheally with a genetically similar but pathogenic clone of MVV. Four unvaccinated sheep were infected simultaneously. All sheep became infected by the challenge virus. The vaccinated sheep were not protected against superinfection with the challenge clone. However, virus was isolated more frequently from the blood of the unvaccinated controls than of the vaccinated animals and ten times more frequently from lungs of unvaccinated sheep than from lungs of vaccinated sheep at sacrifice, indicating partial protection.
Pétursson
Gudmundur
G
Institute for Experimental Pathology, University of Iceland, Keldur v/Vesturlandsveg, Reykjavik, Iceland. gpet@hi.is
Matthíasdóttir
Sigrídur
S
Svansson
Vilhjálmur
V
Andrésdóttir
Valgerdur
V
Georgsson
Gudmundur
G
Martin
Agnes H
AH
Agnarsdóttir
Gudrún
G
Gísladóttir
Eygló
E
Arnadóttir
Steinunn
S
Högnadóttir
Svava
S
Jónsson
Stefán Ragnar
SR
Andrésson
Olafur S
OS
Torsteinsdóttir
Sigurbjörg
S
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis / Q000096:biosynthesis; D003001:Cloning, Molecular; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D018928:Immunity, Mucosal / Q000276:immunology*; D017403:In Situ Hybridization; D012756:Sheep; D015163:Superinfection / Q000517:prevention & control; D014613:Vaccines, Attenuated / Q000276:immunology; D019562:Viral Load; D014765:Viral Vaccines / Q000276:immunology*; D016182:Visna / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D014790:Visna-maedi virus / Q000276:immunology* / Q000302:isolation & purification
D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines