Polymeric micelles and nanoparticles from block and statistical poly((RS)-3,3-dimethylmalic acid) derivatives: preparation and characterization.
Amphiphilic and biodegradable micelles and nanoparticles designed as potential drug carriers were prepared from biodegradable statistical and block copolyesters obtained by a living anionic ring-opening process. These novel materials display amphiphilic properties arising from the joint presence of hydrophilic poly((RS)-3,3-dimethylmalic acid) and hydrophobic poly(hexyl (RS)-3,3-dimethylmalate) segments. Micelles obtained from a well-defined block copolymer have been characterized by their critical aggregation concentration, and nanoparticles derived from statistical copolymer have been analyzed by transmission electron microscopy (TEM).
Ouhib
Farid
F
Laboratoire de Recherche sur les Polyméres, UMR C7581 CNRS-Université Paris XII, 2-8 Rue Henri Dunant, F-94320 Thiais, France.
Randriamahefa
Solo
S
Wintgens
Véronique
V
Guérin
Philippe
P
Barbaud
Christel
C
D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D008293:Malates / Q000737:chemistry*; D008823:Micelles; D008854:Microscopy, Electron; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*
C505108:3,3-dimethylmalic acid; D004337:Drug Carriers; D008293:Malates; D008823:Micelles; D011108:Polymers