title: Short-term effects of arsenic sulfur in deficits of contractile and relaxant responses on urinary bladder: pharmacological and structural changes.
abstract: BACKGROUND
  Our goal was to investigate the effects of arsenic sulfur (AsS) on the detrusor smooth muscle reactivity.
  
  
  METHODS
  AsS (100 ppm microg/g) in drinking water was administered for 2 weeks to two groups of female Wistar rats. The contractile responses of urinary bladders to electrical field stimulation, carbachol, ATP and KCl, and the relaxant responses to ATP, adenosine and isoproterenol were examined. Urinary bladder strips were collected for light microscopic examination.
  
  
  RESULTS
  Our results demonstrate that oral inorganic AsS exposure induced enhanced contractile and reduced relaxant responses in rats. We hypothesize that AsS is involved in deficiencies of isolated urinary bladder in rats.
  
  
  CONCLUSIONS
  These functional and morphological changes may be important as an intermediate link in urinary bladder oncogenesis induced by AsS.
authors.affiliation: Department of Pharmacology, College of Pharmacy, Ankara University, Ankara, Turkey. sgur@pharmacy.ankara.edu.tr
authors.forename: Serap
authors.initials: S
authors.lastname: Gür
authors.forename: A Umran
authors.initials: AU
authors.lastname: Dogan
authors.forename: Meral
authors.initials: M
authors.lastname: Dogan
authors.forename: S Tuna
authors.initials: ST
authors.lastname: Karahan
authors.forename: Belgin
authors.initials: B
authors.lastname: Can
authors.forename: Gaye
authors.initials: G
authors.lastname: Hafez
authors.forename: Ozan
authors.initials: O
authors.lastname: Ozgunes
authors.forename: Muammer
authors.initials: M
authors.lastname: Kendirci
mesh_terms: D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001152:Arsenicals / Q000494:pharmacology*; D002217:Carbachol / Q000494:pharmacology; D018679:Cholinergic Agonists / Q000494:pharmacology; D004558:Electric Stimulation; D005260:Female; D009119:Muscle Contraction / Q000187:drug effects* / Q000502:physiology; D009126:Muscle Relaxation / Q000187:drug effects* / Q000502:physiology; D009130:Muscle, Smooth / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013440:Sulfides / Q000494:pharmacology*; D001743:Urinary Bladder / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D019459:Urothelium / Q000166:cytology / Q000187:drug effects
chemical_list: D001152:Arsenicals; D018679:Cholinergic Agonists; D013440:Sulfides; C045816:arsenic trisulfide; D011189:Potassium Chloride; D000255:Adenosine Triphosphate; D002217:Carbachol