title: Characteristics and expression of tetracycline resistance in gram-negative bacteria carrying the Pseudomonas R factor RP1.
abstract: The Pseudomonas R factor RP1 determines an inducible tetracycline resistance similar to that described for Escherichia coli R factors. The level of RP1-determined resistance measured by minimal inhibitory concentration testing is dependent on the host bacteria and corresponds to the magnitude of decrease in tetracycline accumulation by RP1-containing organisms. The tetracycline resistance mechanism is inactivated at low temperatures. The effect of metabolic inhibitors on tetracycline accumulation by susceptible organisms under various conditions indicates a possible nonspecific effect of cellular energy metabolism on tetracycline uptake.
authors.forename: P L
authors.initials: PL
authors.lastname: Shipley
authors.forename: R H
authors.initials: RH
authors.lastname: Olsen
mesh_terms: D004734:Energy Metabolism; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000235:genetics; D011549:Pseudomonas / Q000235:genetics*; D011815:R Factors; D013696:Temperature; D013752:Tetracycline / Q000493:pharmacokinetics; D013753:Tetracycline Resistance
chemical_list: D013752:Tetracycline