title: Treatment of massive hypertriglyceridemia resistant to PUFA and fibrates: a possible role for the coenzyme Q10?
abstract: OBJECTIVE
  To describe the effect of CoQ10 (added to either a fibrate, or PUFA or association of both) in patients affected by massive hypertriglyceridemia (MHTG) resistant to fibrates and PUFA.
  
  
  METHODS
  Open, sequential, comparative intervention study.
  
  
  METHODS
  Specialised centres for dyslipidemia management.
  
  
  METHODS
  15 subjects (mean age: 45.1 +/- 12.5 years) affected by MHTG and hyporesponsive to either fibrates, or PUFA, or fibrates-PUFA association, and 15 age-matched subjects regularly responders to PUFA and fenofibrate treatment.
  
  
  METHODS
  Treatment for periods of 6 weeks each with the following consecutive treatments: CoQ10 150 mg/day, PUFA 3000 mg/day, fenofibrate 200 mg/day, PUFA 3000 mg/day + fenofibrate 200 mg/day, PUFA 3000 mg/day + CoQ10 150 mg/day, fenofibrate 200 mg/day + CoQ10 150 mg/day, and finally, fenofibrate 200 mg/day + PUFA 3000 mg/day + CoQ10 150 mg/day.
  
  
  RESULTS
  CoQ10 supplementation improved, in the control group, systolic and diastolic blood pressure, creatinine and Lp(a) plasma levels, both during fenofibrate and/or PUFA treatment. In MHTG group, CoQ10 supplementation significantly improved TG, TC, Lp(a), uric acid and blood pressure during fenofibrate treatment, but only Lp(a) and blood pressure during PUFA treatment. Fenofibrate appeared to have better effect on hsCRP and gamma-GT plasma levels than PUFA. No significant change was observed in any group and under any treatment in regards to homocysteinemia, PAI-1, or t-PA.
  
  
  CONCLUSIONS
  Even though the mechanism of action through which the effects were obtained is yet to be elucidated, adding CoQ10 to fenofibrate could improve the drug's efficacy in MHTG patients not responding to fenofibrate alone.
authors.affiliation: GC Descovich Atherosclerosis Research Centre, D. Campanacci Clinical Medicine and Applied Biotechonology Department, S. Orsola-Malpighi Hospital, University of Bologna, Italy. afgcicero@cardionet.it
authors.forename: A F G
authors.initials: AF
authors.lastname: Cicero
authors.forename: G
authors.initials: G
authors.lastname: Derosa
authors.forename: A
authors.initials: A
authors.lastname: Miconi
authors.forename: L
authors.initials: L
authors.lastname: Laghi
authors.forename: S
authors.initials: S
authors.lastname: Nascetti
authors.forename: A
authors.initials: A
authors.lastname: Gaddi
mesh_terms: D000328:Adult; D001794:Blood Pressure; D002784:Cholesterol / Q000097:blood; D003067:Coenzymes; D003404:Creatinine / Q000097:blood; D004032:Diet; D004351:Drug Resistance; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005260:Female; D011345:Fenofibrate / Q000008:administration & dosage*; D006801:Humans; D015228:Hypertriglyceridemia / Q000188:drug therapy*; D017270:Lipoprotein(a) / Q000097:blood; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014527:Uric Acid / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D003067:Coenzymes; D015525:Fatty Acids, Omega-3; D017270:Lipoprotein(a); D014280:Triglycerides; D014451:Ubiquinone; D014527:Uric Acid; D002784:Cholesterol; D003404:Creatinine; D005723:gamma-Glutamyltransferase; C024989:coenzyme Q10; D011345:Fenofibrate