title: [Cefepime-induced encephalopathy: clinical and electroencephalographic features in seven patients].
abstract: Cefepime, a fourth-generation cephalosporin, with large antibacterial spectrum, is a commonly used antibiotic for the treatment of serious hospital infections. Its security report is considered favourable. Recently, many cases of a severe and reversible cefepime-induced encephalopathy were described. In this paper, we report seven patients with reversible cefepime-induced encephalopathy, with a peculiar EEG pattern, characterized by semiperiodic diffuse triphasic waves. We discuss the EEG abnormalities found and their association with nonconvulsive status epilepticus.
authors.affiliation: Unidade de Eletroencefalografia, Hospital de Clínicas, Porto Alegre, RS, Brazil. jabragatti@terra.com.br
authors.forename: José Augusto
authors.initials: JA
authors.lastname: Bragatti
authors.forename: Roberto
authors.initials: R
authors.lastname: Rossato
authors.forename: Sofia
authors.initials: S
authors.lastname: Ziomkowski
authors.forename: Frederico Arthur Dahne
authors.initials: FA
authors.lastname: Kliemann
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000077723:Cefepime; D002511:Cephalosporins / Q000009:adverse effects*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020258:Neurotoxicity Syndromes / Q000209:etiology*
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000077723:Cefepime