title: Identification of ethylsuccinylcarnitine present in some human urines.
abstract: Ethylsuccinylcarnitine, a previously undescribed acylcarnitine, was identified in urines obtained from 81% of adult volunteers. Its chemical structure was obtained by 1H nuclear magnetic resonance spectroscopy of the urinary purified compound and confirmed by its chemical synthesis. Its urinary excretion followed a circadian rhythm with a maximum occurring between 8 p.m. and 1 a.m. Excretion of this compound was enhanced after a load of L-carnitine and in this case, total 24-h urinary excretion may raise up to about 75 microM. It was observed that the day after adryamicine treatment, the compound was no more excreted. This molecule was absent or in trace amounts in urines obtained from few adults as well as in urines obtained from young subjects. In the positive urines, we detected an unknown organic acid whose excretion was almost parallel to that of ethylsuccinylcarnitine.
authors.affiliation: Département de Biologie Clinique, Cliniques Universitaires St. Luc, Avenue Hippocrate10, B-1200, Brussels, Belgium. Raymond.Libert@clin.ucl.ac.be
authors.forename: Raymond
authors.initials: R
authors.lastname: Libert
authors.forename: François
authors.initials: F
authors.lastname: Van Hoof
authors.forename: Georges
authors.initials: G
authors.lastname: Laus
authors.forename: Philippe
authors.initials: P
authors.lastname: De Nayer
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Habib Jiwan
authors.forename: Edmond
authors.initials: E
authors.lastname: de Hoffmann
authors.forename: André
authors.initials: A
authors.lastname: Schanck
mesh_terms: D000328:Adult; D000368:Aged; D002331:Carnitine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000652:urine; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: C503203:ethylsuccinylcarnitine; D002331:Carnitine