title: Compliance as a critical consideration in patients who appear to be resistant to aspirin after healing of myocardial infarction.
abstract: The hypothesis that aspirin resistance is often due to noncompliance was investigated. One hundred ninety patients with a history of myocardial infarction were evaluated using arachidonic acid-stimulated light aggregometry at 3 different time points: while receiving their usual daily aspirin, after not receiving aspirin for 7 days, and 2 hours after the observed ingestion of aspirin 325 mg. At the first time point, 17 patients (9%) failed to show aspirin inhibition of platelet aggregation, but 2 hours after observed aspirin ingestion, aspirin inhibition was observed in all but 1 patient.
authors.affiliation: Department of Medicine, Michigan State University, East Lansing 48824, USA. schwart7@msu.edu <schwart7@msu.edu>
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Schwartz
authors.forename: Dianne E
authors.initials: DE
authors.lastname: Schwartz
authors.forename: Khalid
authors.initials: K
authors.lastname: Ghosheh
authors.forename: Mathew J
authors.initials: MJ
authors.lastname: Reeves
authors.forename: Kimberly
authors.initials: K
authors.lastname: Barber
authors.forename: Anthony
authors.initials: A
authors.lastname: DeFranco
mesh_terms: D016718:Arachidonic Acid; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D004351:Drug Resistance; D006801:Humans; D009203:Myocardial Infarction; D010349:Patient Compliance; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: D010975:Platelet Aggregation Inhibitors; D016718:Arachidonic Acid; D001241:Aspirin