Imprinted genes in the placenta--a review.
Imprinted genes are expressed monoallelically depending on their parental origin. High expression of the majority of imprinted genes tested to date has been demonstrated in extraembryonic tissues; placenta and yolk sac. Several mouse models where specific imprinted genes have been disrupted demonstrate that fetal and placental growth may be regulated by imprinted genes, in which paternally expressed genes enhance, and maternally expressed genes restrain, growth. We review the current information on, and suggest possible functional roles for, imprinted genes in placental development.
Coan
P M
PM
Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK. pmc40@cam.ac.uk
Burton
G J
GJ
Ferguson-Smith
A C
AC
D000818:Animals; D002875:Chromosomes / Q000235:genetics; D005260:Female; D047109:Fetal Development / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D018390:Gene Targeting; D018392:Genomic Imprinting; D006801:Humans; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D010641:Phenotype; D010920:Placenta / Q000378:metabolism*; D010929:Placentation; D011247:Pregnancy; D014960:X Chromosome / Q000235:genetics