Thermosensitive biodegradable polydepsipeptide.
A poly(N-isopropylacrylamide) (PNIPAAm)-like biodegradable thermosensitive polydepsipeptide, poly[Glc-Asn(N-isopropyl)], was synthesized by introducing an isopropyl amide group into poly[Glc-Asn]. Poly[Glc-Asn(N-isopropyl)] was degraded in vitro by cleavage of the ester bonds in the main chain in water at room temperature. The non-toxic nature of the polymer and its degradation products, coupled with a cloud point at 29 degrees C in water, make this polymer attractive for biomedical implant applications.
Ohya
Yuichi
Y
Department of Applied Chemistry, Faculty of Engineering, Kansai University, 3-3-35 Yamate-cho, Suita, Osaka 564-8680, Japan. yohya@ipcku.kansai-u.ac.jp
Toyohara
Megumi
M
Sasakawa
Mitsuhiro
M
Arimura
Hidetoshi
H
Ouchi
Tatsuro
T
D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000378:metabolism* / Q000633:toxicity; D001673:Biodegradation, Environmental; D002470:Cell Survival; D002478:Cells, Cultured; D047630:Depsipeptides / Q000138:chemical synthesis / Q000378:metabolism* / Q000633:toxicity; D005347:Fibroblasts / Q000187:drug effects; D051379:Mice; D010455:Peptides / Q000138:chemical synthesis / Q000378:metabolism / Q000633:toxicity; D013696:Temperature
D001672:Biocompatible Materials; D047630:Depsipeptides; D010455:Peptides; C505107:poly(glycolic acid-co-N-isopropylasparagine)