Liver transplantation for hepatocellular carcinoma: is expansion of criteria justified?
Hepatocellular carcinoma (HCC) is a major health problem worldwide, involving more than a half million new cases yearly, with an age-adjusted incidence of 5.5 to 14.9 per 10(5) population. In some areas of Asia and the Middle East, HCC ranks as the first cause of death due to cancer. The incidence of HCC is increasing in Europe and the United States, and it is currently the leading cause of death among cirrhotic patients. It is estimated that by the year 2010, the number of patients with HCC awaiting liver transplant in the United States will outnumber the supply of cadaver organs.
Roayaie
Sasan
S
Division of Liver Diseases and Recanati/Miller Transplantation Institute, Mount Sinai School of Medicine, New York, NY 10029, USA.
Llovet
Josep M
JM
D002102:Cadaver; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D005544:Forecasting; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016031:Liver Transplantation / Q000592:standards* / Q000639:trends; D008297:Male; D009367:Neoplasm Staging; D018570:Risk Assessment; D016019:Survival Analysis; D014019:Tissue Donors; D009927:Tissue and Organ Procurement / Q000592:standards* / Q000639:trends; D014850:Waiting Lists