title: Application of microwave irradiation to the synthesis of 14-helical beta-peptides.
abstract: [structure: see text] We have evaluated the effects of microwave irradiation on the solid-phase synthesis of beta-peptides. Sequences designed to adopt the 14-helix, especially those containing the structure-promoting residue trans-2-aminocyclohexanecarboxylic acid (ACHC), suffer from poor synthetic efficiency under standard SPPS conditions. A comparison of microwave and conventional heating shows that both provide excellent synthetic results for shorter sequences; however, we identify a clear benefit from microwave irradiation for longer beta-peptides.
authors.affiliation: Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.
authors.forename: Justin K
authors.initials: JK
authors.lastname: Murray
authors.forename: Samuel H
authors.initials: SH
authors.lastname: Gellman
mesh_terms: D020650:Combinatorial Chemistry Techniques; D008872:Microwaves; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis*; D017433:Protein Structure, Secondary
chemical_list: D010455:Peptides