Actions of adenosine at its receptors in the CNS: insights from knockouts and drugs.
Adenosine and its receptors have been the topic of many recent reviews. These reviews provide a good summary of much of the relevant literature--including the older literature. We have, therefore, chosen to focus the present review on the insights gained from recent studies on genetically modified mice, particularly with respect to the function of adenosine receptors and their potential as therapeutic targets. The information gained from studies of drug effects is discussed in this context, and discrepancies between genetic and pharmacological results are highlighted.
Fredholm
Bertil B
BB
Department of Physiology and Pharmacology, Karolinska Institutet, S-17177 Stockholm, Sweden.
Chen
Jiang-Fan
JF
Masino
Susan A
SA
Vaugeois
Jean-Marie
JM
D000241:Adenosine / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D009422:Nervous System Diseases / Q000235:genetics / Q000378:metabolism; D058906:Purinergic P1 Receptor Agonists; D018047:Receptors, Purinergic P1 / Q000235:genetics / Q000378:metabolism*
D058906:Purinergic P1 Receptor Agonists; D018047:Receptors, Purinergic P1; D000241:Adenosine