[Pathomorphology of adenohypophysis in cases of massive obstetric hemorrhages (morphometric and immunohistochemical studies)].
There have been performed morphometric and immunohistochemical examinations of adenohypophysis of 15 females who died of massive post-partum hemorrhages. The revealed changes in the form of hypertrophy of the basophilic cells are the initial stages of Sheehan's syndrome developing as a result of long-term progression of hypopituitarism. Massive obstetric bleeding causes severe complications-posthemorrhagic shock, the pathogenetic mechanism of which includes necrosis of the cells in the anterior part of the hypophysis. Cause-effect relations were shown for the amount of the post-partum blood loss and the revealed pathomorphologic changes in the hypophysis. Hyperproduction of ACTH by the basophilic cells of the adenohypophysis revealed by immunohistochemical analysis is a compensatory mechanism under the conditions of acute adrenal insufficiency inherent in any shock including posthemorrhagic.
Milovanov
A P
AP
Matsionis
A E
AE
Makarenko
Iu M
IuM
D000324:Adrenocorticotropic Hormone / Q000032:analysis / Q000378:metabolism; D005260:Female; D006801:Humans; D006984:Hypertrophy; D007018:Hypopituitarism / Q000150:complications / Q000473:pathology*; D007150:Immunohistochemistry; D008407:Mast Cells / Q000378:metabolism / Q000473:pathology; D009336:Necrosis; D010903:Pituitary Gland, Anterior / Q000378:metabolism / Q000473:pathology*; D006473:Postpartum Hemorrhage / Q000209:etiology / Q000473:pathology*; D011247:Pregnancy; D012771:Shock, Hemorrhagic / Q000209:etiology / Q000473:pathology
D000324:Adrenocorticotropic Hormone