Induction of uteroglobin-related protein 2 (Ugrp2) expression by EGF and TGFalpha.
Uteroglobin-related protein 2 (UGRP2) is thought to play a role in inflammation and/or epithelial cell differentiation in the lung. Induction of Ugrp2 mRNA expression by epidermal growth factor (EGF) and transforming growth factor alpha was examined using mouse transformed lung Clara cell-derived mtCC cells. The EGF-induced increase of Ugrp2 occurred at the transcriptional level that required the EGF receptor and the activation of the ERK-MAPK and phosphoinositide-3 kinase pathways.
Yamada
Atsushi
A
Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Building 37, Room 3112B, 9000 Rockville Pike, Bethesda, MD 20892, USA.
Kimura
Shioko
S
D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D015153:Blotting, Western; D017931:DNA Primers; D004815:Epidermal Growth Factor / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology*; D008168:Lung / Q000166:cytology / Q000378:metabolism; D020935:MAP Kinase Signaling System; D051379:Mice; D011506:Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016211:Transforming Growth Factor alpha / Q000502:physiology*
D017931:DNA Primers; D011506:Proteins; D012333:RNA, Messenger; D016211:Transforming Growth Factor alpha; C470307:UGRP2 protein, mouse; D004815:Epidermal Growth Factor