title: Temperature dependence of tissue impedivity in electrical impedance tomography of cryosurgery.
abstract: The temperature-dependent impedivity of rat liver, transverse abdominal muscle and full skin was determined in vitro as a function of frequency across the temperature range 5 degrees C to 37 degrees C and from 100 Hz to 10 kHz. This study was motivated by an increasing interest in using electrical impedance tomography (EIT) for imaging of cryosurgery and a lack of applicable data in the hypothermic range. Using a controlled-temperature impedance analyzer, it was found that as the temperature is reduced the resulting increase in tissue impedivity is more pronounced at low frequencies and that the beta dispersion, resulting from cell membrane polarization, shifts to lower frequencies. With these new data a simple case study of EIT of liver cryosurgery was examined, using a finite-element model incorporating the Pennes bio-heat equation, to determine the impact of this behavior on imaging accuracy. Overestimation of the ice-front position was found to occur if the EIT system ignored the effects of the low-temperature zone surrounding the frozen tissue. This error decreases with increasing blood perfusion and with higher measurement frequencies.
authors.affiliation: Department of Mechanical Engineering, University of California, Berkeley, CA 94720, USA. jonedd@me.berkeley.edu
authors.forename: Jon F
authors.initials: JF
authors.lastname: Edd
authors.forename: Liana
authors.initials: L
authors.lastname: Horowitz
authors.forename: Boris
authors.initials: B
authors.lastname: Rubinsky
mesh_terms: D000009:Abdominal Muscles / Q000502:physiology; D000818:Animals; D001831:Body Temperature / Q000502:physiology*; D003198:Computer Simulation; D003452:Cryosurgery / Q000379:methods*; D017097:Electric Impedance; D008099:Liver / Q000502:physiology; D008297:Male; D008954:Models, Biological; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012879:Skin Physiological Phenomena; D025321:Surgery, Computer-Assisted / Q000379:methods*; D013696:Temperature; D013817:Thermography / Q000379:methods*; D014054:Tomography / Q000379:methods*