title: A computational view of microRNAs and their targets.
abstract: Small non-coding RNAs called microRNAs have been shown to play important roles in gene regulation across a broad range of metazoans from plants to humans. In this review, the nature and function of microRNAs will be discussed, with special emphasis on the computational tools and databases available to predict microRNAs and the genes they target.
authors.affiliation: GlaxoSmithKline, Bioinformatics Discovery and Analysis, Upper Providence, 1250 South Collegeville Road, UP1345, PO Box 5089, Collegeville, PA 19426-0989, USA.
authors.forename: James R
authors.initials: JR
authors.lastname: Brown
authors.forename: Philippe
authors.initials: P
authors.lastname: Sanseau
mesh_terms: D000818:Animals; D018390:Gene Targeting / Q000379:methods* / Q000639:trends; D006801:Humans; D035683:MicroRNAs / Q000494:pharmacology* / Q000502:physiology*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods
chemical_list: D035683:MicroRNAs