title: Disseminated Scedosporium prolificans infection and survival of a child with acute lymphoblastic leukemia.
abstract: Scedosporium prolificans is a saprophytic fungus responsible for an increasing number of infections among immunocompromised hosts. Historically, disseminated infection with this organism has resulted in death. We report on a pediatric patient who developed overwhelming S. prolificans sepsis after induction chemotherapy for acute lymphoblastic leukemia. She is well 18 months after the diagnosis of fungal sepsis and continues to receive chemotherapy for leukemia, which remains in remission.
authors.affiliation: Department of Pediatric Oncology, Banksia Unit, Royal Children's Hospital, Herston, Brisbane, Queensland, Australia 4029. morag_whyte@health.qld.gov.au
authors.forename: Morag
authors.initials: M
authors.lastname: Whyte
authors.forename: Helen
authors.initials: H
authors.lastname: Irving
authors.forename: Peter
authors.initials: P
authors.lastname: O'Regan
authors.forename: Michael
authors.initials: M
authors.lastname: Nissen
authors.forename: David
authors.initials: D
authors.lastname: Siebert
authors.forename: Robert
authors.initials: R
authors.lastname: Labrom
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D002648:Child; D005260:Female; D016469:Fungemia / Q000188:drug therapy* / Q000382:microbiology*; D006801:Humans; D016867:Immunocompromised Host; D008271:Mycetoma / Q000188:drug therapy* / Q000382:microbiology*; D009281:Naphthalenes / Q000627:therapeutic use; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D011743:Pyrimidines / Q000627:therapeutic use; D021681:Scedosporium / Q000145:classification / Q000302:isolation & purification*; D000077291:Terbinafine; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D011743:Pyrimidines; D014230:Triazoles; D000077291:Terbinafine; D065819:Voriconazole