title: Adenovirus infection in children after allogeneic stem cell transplantation: diagnosis, treatment and immunity.
abstract: Human adenoviruses (HAdV) are a frequent cause of potentially fatal infections in patients after allogeneic stem cell transplantation, especially in children. Monitoring of serum/plasma by real-time quantitative PCR is a sensitive tool for the recognition of patients at risk of a potentially fatal infection and for the evaluation of the efficacy of treatment. Data from a retrospective study and from a prospective study demonstrate that recovery of immunity after transplantation is essential for the elimination of HAdV infection. The feasibility of several approaches for the manipulation of immunity in the immunocompromised host to prevent a fatal course of the infection is discussed.
authors.affiliation: Department of Paediatrics, Leiden University Medical Centre, Leiden, The Netherlands. M.J.D.van_Tool@LUMC.nl
authors.forename: M J D
authors.initials: MJ
authors.lastname: van Tol
authors.forename: E C J
authors.initials: EC
authors.lastname: Claas
authors.forename: B
authors.initials: B
authors.lastname: Heemskerk
authors.forename: L A
authors.initials: LA
authors.lastname: Veltrop-Duits
authors.forename: C S
authors.initials: CS
authors.lastname: de Brouwer
authors.forename: T
authors.initials: T
authors.lastname: van Vreeswijk
authors.forename: C C
authors.initials: CC
authors.lastname: Sombroek
authors.forename: A C M
authors.initials: AC
authors.lastname: Kroes
authors.forename: M F C
authors.initials: MF
authors.lastname: Beersma
authors.forename: E P A
authors.initials: EP
authors.lastname: de Klerk
authors.forename: R M
authors.initials: RM
authors.lastname: Egeler
authors.forename: A C
authors.initials: AC
authors.lastname: Lankester
authors.forename: M W
authors.initials: MW
authors.lastname: Schilham
mesh_terms: D000258:Adenovirus Infections, Human / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D033581:Stem Cell Transplantation; D014184:Transplantation, Homologous
chemical_list: D004279:DNA, Viral