Geographic pathology of Helicobacter pylori gastritis.
OBJECTIVE
Helicobacter pylori is etiologically associated with gastritis and gastric cancer. There are significant geographical differences between the clinical manifestation of H. pylori infections. The aim of this study was to compare gastric mucosal histology in relation to age among H. pylori-infected patients from different geographical areas using the same grading system. The prevalence of atrophy and intestinal metaplasia were also compared with the respective gastric cancer incidence in the different countries.


METHODS
A total of 1906 patients infected with H. pylori from seven countries were evaluated. Entry criteria included H. pylori positive cases with antral and corpus biopsies between the ages of 18 and 75 years. The minimum number of cases required from a country was 100. Hematoxylin-eosin stained biopsies from antrum and corpus were scored semiquantitatively using the parameters suggested by the Sydney Classification System. Statistical evaluation was performed using Kruskal-Wallis test and Spearman's rank correlation test.


RESULTS
The severity of gastric atrophy varied among the different groups with the highest scores being present in Japan. The lowest scores were found in four European countries and in Thailand. The scores for intestinal metaplasia were low in general except for Xi-an, Japan, and Shanghai. For all the countries, the presence of atrophy in the antrum correlated well (r = 0.891) with the incidence of gastric cancer.


CONCLUSIONS
Using a standardized grading system in a large study of H. pylori-related geographic pathology, we found major differences in the overall prevalence and severity of H. pylori gastritis in relation to age. These differences mirrored the respective incidences of gastric cancer in those geographical areas.
Liu
Yi
Y
Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. y.liu@amc.uva.nl
Ponsioen
Cyriel I J
CI
Xiao
Shu-Dong
SD
Tytgat
Guido N J
GN
Ten Kate
Fiebo J W
FJ
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001208:Asia / Q000453:epidemiology; D001284:Atrophy; D001706:Biopsy; D005060:Europe / Q000453:epidemiology; D005756:Gastritis / Q000453:epidemiology* / Q000208:ethnology / Q000473:pathology; D016481:Helicobacter Infections / Q000453:epidemiology* / Q000208:ethnology / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D008679:Metaplasia; D008875:Middle Aged; D015995:Prevalence; D011706:Pyloric Antrum / Q000382:microbiology / Q000473:pathology; D012737:Sex Factors; D013274:Stomach Neoplasms / Q000453:epidemiology