[The effects of artificial analogue peptide TSKY isolated from the brain of hibernating ground squirrels in rats and mice].
Elevation of the i.c.v. injection dose of TSKY from 4 to 8 microg increased the movement activity of rats; in EEG theta- and beta-rhythms were enhanced and alpha-rhythm was suppressed. On the contrary, after treatment of 15 microg the rats fell into sleepy-like state; theta- and beta2-rhythms suppression, delta-, alpha- and beta1-rhythms were increased. Exposure under hypoxia-hypercapnia conditions reduced body temperature of mice to 18-19 degrees C, and maintain this state about 3-4 h after transferring into conventional gas medium. Preliminary cooling mice were administrated with TSKY that at dose 100 microg intraperitonally induced a prolonged hypothermia up to 12 h. Analogous injection without cooling raised mice temperature by 1.2 degrees C during about 2 h.
Ignat'ev
D A
DA
Vorob'ev
V V
VV
Zikhanshin
R Kh
RKh
D000513:Alpha Rhythm; D000818:Animals; D001611:Beta Rhythm; D001923:Brain Chemistry; D004569:Electroencephalography; D004723:Endorphins / Q000008:administration & dosage / Q000032:analysis* / Q000494:pharmacology*; D006605:Hibernation / Q000502:physiology*; D007274:Injections, Intraperitoneal; D008124:Locomotion / Q000187:drug effects*; D051379:Mice; D010446:Peptide Fragments / Q000008:administration & dosage / Q000032:analysis* / Q000494:pharmacology*; D051381:Rats; D012589:Sciuridae
D004723:Endorphins; D010446:Peptide Fragments; C100744:neokyotorphin (1-4)