title: Rectosigmoid findings are not associated with proximal colon cancer: analysis of 6 196 consecutive cases undergoing total colonoscopy.
abstract: OBJECTIVE
  To review the risk of proximal colon cancer in patients undergoing colonoscopy.
  
  
  METHODS
  We estimated the risk of advanced proximal adenomas and cancers in 6 196 consecutive patients that underwent colonoscopy (mean age 60 years, 65% males, without prior history of colorectal examination). Neoplasms were classified as diminutive adenoma (5 mm or less), small adenoma (6-9 mm), advanced adenoma (10 mm or more, with villous component or high-grade dysplasia) and cancer (invasive adenocarcinoma). The sites of neoplasms were defined as rectosigmoid (rectum and sigmoid colon) and proximal colon (from cecum to descending colon).
  
  
  RESULTS
  The trend of the prevalence of advanced proximal adenoma was to increase with severe rectosigmoid findings, while the prevalence of proximal colon cancer did not increase with severe rectosigmoid findings. Among the 157 patients with proximal colon cancer, 74% had no neoplasm in the rectosigmoid colon. Multivariate logistic-regression analysis revealed that age was the main predictor of proximal colon cancer and existence of rectosigmoid adenoma was not a predictor of proximal colon cancer.
  
  
  CONCLUSIONS
  Sigmoidoscopy is inadequate for colorectal cancer screening, especially in older populations.
authors.affiliation: Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. okamoto-2im@h.u-tokyo.ac.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Okamoto
authors.forename: Takao
authors.initials: T
authors.lastname: Kawabe
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yamaji
authors.forename: Jun
authors.initials: J
authors.lastname: Kato
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Ikenoue
authors.forename: Goichi
authors.initials: G
authors.lastname: Togo
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Yoshida
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Shiratori
authors.forename: Masao
authors.initials: M
authors.lastname: Omata
mesh_terms: D000236:Adenoma / Q000453:epidemiology* / Q000473:pathology*; D000368:Aged; D002432:Cecum / Q000473:pathology; D044683:Colon, Descending / Q000473:pathology; D012809:Colon, Sigmoid / Q000473:pathology; D003110:Colonic Neoplasms / Q000453:epidemiology* / Q000473:pathology*; D003113:Colonoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012007:Rectum / Q000473:pathology; D012307:Risk Factors