title: Reference values of CD4 T lymphocytes in human immunodeficiency virus-negative adult Nigerians.
abstract: A cross-sectional study that involved secondary analysis of data collected from 681 pregnant women and 183 miners (94 men and 89 women; ratio of men to women, 1:0.95) in Jos, Nigeria, was carried out to determine the reference ranges for CD4(+)-cell counts in healthy HIV-negative adult Nigerians. The main results of interest were CD4(+)-cell counts and odds ratios (ORs) of low CD4(+)-cell counts, defined as below 350 cells per microl. CD4(+)-cell counts were similar in men and nonpregnant women, with a mean (standard deviation) of 828 (203) cells per microl, but pregnant women had a lower value of 771 (250) cells per microl. None of the factors assessed was related to the odds of having a low CD4(+)-cell count among men and nonpregnant women, but age, age of marriage, and alcohol usage were significant predictors in pregnant women. Compared to pregnant women less than 20 years old, older women had significantly lower odds of a low CD4(+)-cell count (ORs were 0.06 for women aged 20 to 29 years and 0.22 for those aged 30 to 39 years). When compared with those pregnant women who were married before 20 years of age, those who married at 20 to 29 years and 30 to 39 years had odds ratios of 6.41 and 9.40, respectively. Previous alcohol use was also associated with low CD4(+)-cell counts (OR, 5.15). The 95% confidence interval for CD4(+)-cell counts in healthy adult Nigerians is 547 to 1,327 cells per microl, and this is the first time this has been determined.
authors.affiliation: Division of Epidemiology and Prevention, Institute of Human Virology, Baltimore, Maryland 21201, USA.
authors.forename: Olumuyiwa
authors.initials: O
authors.lastname: Aina
authors.forename: Jelpe
authors.initials: J
authors.lastname: Dadik
authors.forename: Manhattan
authors.initials: M
authors.lastname: Charurat
authors.forename: Patience
authors.initials: P
authors.lastname: Amangaman
authors.forename: Silas
authors.initials: S
authors.lastname: Gurumdi
authors.forename: Edwina
authors.initials: E
authors.lastname: Mang
authors.forename: Ruth
authors.initials: R
authors.lastname: Guyit
authors.forename: Ndam
authors.initials: N
authors.lastname: Lar
authors.forename: Pam
authors.initials: P
authors.lastname: Datong
authors.forename: Comfort
authors.initials: C
authors.lastname: Daniyam
authors.forename: Phyllis
authors.initials: P
authors.lastname: Kanki
authors.forename: Alash'le
authors.initials: A
authors.lastname: Abimiku
mesh_terms: D000328:Adult; D000367:Age Factors; D000428:Alcohol Drinking; D018791:CD4 Lymphocyte Count / Q000379:methods; D015496:CD4-Positive T-Lymphocytes; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D003710:Demography; D005260:Female; D018023:HIV Seronegativity / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D008297:Male; D008393:Marriage; D008403:Mass Screening; D009548:Niger; D016017:Odds Ratio; D011247:Pregnancy; D016016:Proportional Hazards Models; D012016:Reference Values; D012307:Risk Factors; D019562:Viral Load