title: Systemic leukocyte activation in patients with central giant cell lesions.
abstract: BACKGROUND
  Central giant cell lesion (CGCL) is a reactive lesion of the jaws with an associated inflammatory infiltrate. Since cell circulation allows for intense communication between different compartments in the body, we investigated whether the CGCL would lead to phenotypic and/or functional changes in circulating leukocytes.
  
  
  METHODS
  We obtained lymphocytes and monocytes from CGCL patients and control subjects, to evaluate cytokine and adhesion molecule expression using flow cytometry.
  
  
  RESULTS
  Our results revealed that CD4(+) T cells and CD14(+) monocytes from CGCL express elevated levels of CD11a and CD11b, respectively, when compared with controls. The frequencies of CD4(+) T cells expressing interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha and the frequencies of CD4(+) and CD14(+) cells expressing interleukin (IL)-10 were increased in CGCL group, when compared with controls.
  
  
  CONCLUSIONS
  Our data indicate that, although CGCL is a localized lesion, the patients show systemic functional alterations in circulating leukocytes, suggesting their role in the inflammatory pathogenesis of CGCL.
authors.affiliation: Dentistry School, Pontifícia Universidade Católica de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Paulo Eduardo Alencar
authors.initials: PE
authors.lastname: de Souza
authors.forename: Ricardo Santiago
authors.initials: RS
authors.lastname: Gomez
authors.forename: Guilherme Machado
authors.initials: GM
authors.lastname: Xavier
authors.forename: Janete Soares Coelho
authors.initials: JS
authors.lastname: dos Santos
authors.forename: Kenneth John
authors.initials: KJ
authors.lastname: Gollob
authors.forename: Walderez Ornelas
authors.initials: WO
authors.lastname: Dutra
mesh_terms: D000328:Adult; D015815:Cell Adhesion Molecules / Q000096:biosynthesis; D016207:Cytokines / Q000096:biosynthesis; D005260:Female; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D006101:Granuloma, Giant Cell / Q000276:immunology*; D006801:Humans; D007962:Leukocytes / Q000276:immunology* / Q000378:metabolism*; D008213:Lymphocyte Activation; D008297:Male; D008336:Mandibular Diseases / Q000276:immunology*; D009000:Monocytes / Q000276:immunology
chemical_list: D015815:Cell Adhesion Molecules; D016207:Cytokines