[Analysis of pathogenesis of pneumonia post allogeneic hematopoietic stem cell transplantation].
OBJECTIVE
To analyse the clinical features and pathogenesis of pneumonia post allogeneic hematopoietic stem cell transplantation (HSCT).


METHODS
Analysis was made of 255 patients of recipients of allo-HSCT from 1998 to 2001.


RESULTS
Seventy-two episodes of pneumonia occurred in 66 patients with the morbidity of 25.9%; 50 (75%) patients were cured. Twelve episodes (16.7%) were caused by mixed infection of bacteria and fungi; 22 episodes (30.6%) were caused by cytomegalovirus infection and 36 episodes (50.0%) were classified as idiopathic pneumonia syndrome. The total mortility of pneumonia post allo-HSCT in our institute was 22.7%. The occurrence of chronic graft-versus-host disease was significantly high in idiopathic pneumonia syndrome, in which good response to immune suppressive therapy was observed.


CONCLUSIONS
Pneumonia post allo-HSCT is a common complication, of which pathogenesis includes infection and non-infection. Its clinical outcome could be improved by specific therapy.
Liu
Dai-hong
DH
Institute of Hematology, Peking University People's Hospital, Beijing 100044, China.
Huang
Xiao-jun
XJ
Guo
Nai-lan
NL
Xu
Lan-ping
LP
Chen
Huan
H
Han
Wei
W
Jiang
Qian
Q
Liu
Kai-yan
KY
Lu
Dao-pei
DP
D000293:Adolescent; D000328:Adult; D002648:Child; D002681:China / Q000453:epidemiology; D003586:Cytomegalovirus Infections / Q000453:epidemiology / Q000209:etiology; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000453:epidemiology* / Q000382:microbiology*; D018410:Pneumonia, Bacterial / Q000453:epidemiology / Q000209:etiology; D011024:Pneumonia, Viral / Q000453:epidemiology / Q000209:etiology