[An update on the pharmacological treatment of Alzheimer disease].
Dementia in general, especially Alzheimer disease and vascular dementia, are diseases of high prevalence with severe socio-economic consequences in all countries. In recent years, due to the obtention of new pharmaceutical products acting on different brain neurotransmitters, there has been important changes in the therapy of these diseases. Although these drugs do not stop disease progression, there is consistent evidence of their usefulness in cognitive, behavioral and functional domains and of their pharmaco-economical justification. This article reviews the main drugs available for Alzheimer disease and some future therapeutic perspectives.
Fuentes
Patricio
P
Unidad de Neurología Cognitiva y Demencias, Servicio de Neurología, Hospital del Salvador, Santiago, Chile.
Slachevsky
Andrea
A
D000109:Acetylcholine / Q000627:therapeutic use; D000544:Alzheimer Disease / Q000188:drug therapy*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D018698:Glutamic Acid / Q000627:therapeutic use; D006801:Humans; D018377:Neurotransmitter Agents / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use
D002800:Cholinesterase Inhibitors; D018377:Neurotransmitter Agents; D014665:Vasodilator Agents; D018698:Glutamic Acid; D000109:Acetylcholine