title: Chiral separation with novel (S)-biotin-bonded silica gel for liquid chromatography.
abstract: Liquid chromatographic separation of enantiomers was accomplished using a chiral stationary phase (CSP) derived from (S)-biotin on silica gel. In both nonaqueous and aqueous media, this CSP (1) permitted separation of racemic amino acid derivatives based on hydrogen bonding with a urea moiety of the biotin moiety.
authors.affiliation: Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. kurata@ps.toyaku.ac.jp
authors.forename: Kaori
authors.initials: K
authors.lastname: Kurata
authors.forename: Satoru
authors.initials: S
authors.lastname: Sakamoto
authors.forename: Akira
authors.initials: A
authors.lastname: Dobashi
mesh_terms: D000596:Amino Acids / Q000302:isolation & purification*; D001710:Biotin / Q000737:chemistry*; D002853:Chromatography, Liquid / Q000295:instrumentation / Q000379:methods*; D004136:Dinitrobenzenes / Q000737:chemistry / Q000302:isolation & purification; D006860:Hydrogen Bonding; D007536:Isomerism; D058428:Silica Gel; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D000596:Amino Acids; D004136:Dinitrobenzenes; D058428:Silica Gel; D001710:Biotin; D012822:Silicon Dioxide