Enantioselective H-atom transfer reaction: a strategy to synthesize formaldehyde aldol products.
[reaction: see text] Enantioselective radical alkylation of Baylis-Hillman adducts furnished aldol products in good yield and selectivity. The results illustrate that the selectivity in the hydrogen atom transfer is dependent on the size of the ester substituent, with smaller substituents providing better enantioselectivity.
Sibi
Mukund P
MP
Department of Chemistry, North Dakota State University, Fargo, North Dakota 58105, USA.
Patil
Kalyani
K
D000447:Aldehydes / Q000032:analysis / Q000138:chemical synthesis*; D000478:Alkylation; D002384:Catalysis; D005557:Formaldehyde / Q000032:analysis / Q000138:chemical synthesis*; D015394:Molecular Structure; D011522:Protons; D013237:Stereoisomerism
D000447:Aldehydes; D011522:Protons; D005557:Formaldehyde; C116609:3-hydroxybutanal