title: [Pharmacokinetics of the methylprednisolone, dexamethasone and hydrocortisone in the inner ear after administered via round window].
abstract: OBJECTIVE
  To compare the pharmacokinetics of Methylprednisolone, Dexamethasone and Hydrocortisone in the inner era of guinea pig after administered via round window.
  
  
  METHODS
  Guinea pig was divided into groups chronologically. After a drop of 100 g/L corticosteroid applied into the round window niche, the tympanic perilymph was sampled chronologically. Concentration of the three corticosteroid in perilymph were measured via HPLC and analyzed by 3P97 software.
  
  
  RESULTS
  The highest concentration of the three drug appeared at 30 min, 60 min and 30 min. Then the concentration declined rapidly.
  
  
  CONCLUSIONS
  All three corticosteroid permeate the round window membrane easily, but the concentration declined rapidly after the peak appearing.
authors.affiliation: Department of Otolaryngology, Union Hospital, Wuhan, China.
authors.forename: Sui
authors.initials: S
authors.lastname: Li
authors.forename: Shusheng
authors.initials: S
authors.lastname: Gong
authors.forename: Jianguo
authors.initials: J
authors.lastname: Chen
authors.forename: Haitao
authors.initials: H
authors.lastname: Lu
authors.forename: Jibao
authors.initials: J
authors.lastname: Wang
mesh_terms: D000287:Administration, Topical; D000818:Animals; D003907:Dexamethasone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007758:Ear, Inner / Q000378:metabolism*; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D010498:Perilymph / Q000378:metabolism*; D012405:Round Window, Ear
chemical_list: D003907:Dexamethasone; D006854:Hydrocortisone; D008775:Methylprednisolone