title: Association between sex, nutritional status, severity of dengue hemorrhagic fever, and immune status in infants with dengue hemorrhagic fever.
abstract: The association between sex, nutritional status, and the severity of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), and immune status was investigated in 245 Vietnamese infants with predominantly primary infections with dengue virus. Male and female infants were at equal risk of developing DHF/DSS. However, infants of low height and weight for age were under-represented among DHF/DSS cases compared with 533 healthy baby clinic infant controls. Acute illness phase blood levels of selected cytokines (interferon-gamma and tumor necrosis factor-alpha) and serum levels of antibodies to dengue virus were elevated in the same range in male and female infants with DHF/DSS, as well as in infants with and without malnutrition.
authors.affiliation: Department of Dengue Hemorrhagic Fever, Children's Hospital No. 1, Ho Chi Minh City, Vietnam. hungdhf@hcm.fpt.vn <hungdhf@hcm.fpt.vn>
authors.forename: Thanh Hung
authors.initials: TH
authors.lastname: Nguyen
authors.forename: Trong Lan
authors.initials: TL
authors.lastname: Nguyen
authors.forename: Huan-Yao
authors.initials: HY
authors.lastname: Lei
authors.forename: Yee-Shin
authors.initials: YS
authors.lastname: Lin
authors.forename: Bich Lien
authors.initials: BL
authors.lastname: Le
authors.forename: Kao-Jean
authors.initials: KJ
authors.lastname: Huang
authors.forename: Chiou-Feng
authors.initials: CF
authors.lastname: Lin
authors.forename: Quang Ha
authors.initials: QH
authors.lastname: Do
authors.forename: Thi Que Huong
authors.initials: TQ
authors.lastname: Vu
authors.forename: Thi My
authors.initials: TM
authors.lastname: Lam
authors.forename: Trai-Ming
authors.initials: TM
authors.lastname: Yeh
authors.forename: Jyh-Hsiung
authors.initials: JH
authors.lastname: Huang
authors.forename: Ching-Chuan
authors.initials: CC
authors.lastname: Liu
authors.forename: Scott B
authors.initials: SB
authors.lastname: Halstead
mesh_terms: D003715:Dengue / Q000276:immunology / Q000503:physiopathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009752:Nutritional Status; D012737:Sex Factors