Sowing the seeds of success: pharmaceutical proteins from plants.
Among the many plant-based production systems that have been developed for pharmaceutical proteins, seeds have the useful advantage of accumulating proteins in a relatively small volume and in a stable environment in which they are protected from degradation. Several seed crops, including cereals, grain legumes and oilseeds, have been explored as production platforms, and the first commercial products -- all technical proteins and enzymes -- have already reached the market. Recent studies have explored the use of seeds for the production of pharmaceutical proteins, particularly replacement human proteins, recombinant antibodies and (oral) vaccines.
Stoger
Eva
E
Institute for Molecular Biotechnology, Biology VII, RWTH Aachen, Worringerweg 1, 52074 Aachen, Germany.
Ma
Julian K-C
JK
Fischer
Rainer
R
Christou
Paul
P
D000906:Antibodies / Q000737:chemistry; D001709:Biotechnology / Q000379:methods*; D002523:Edible Grain / Q000235:genetics; D007887:Fabaceae / Q000235:genetics; D017343:Genes, Plant; D017930:Genes, Reporter; D006801:Humans; D004364:Pharmaceutical Preparations / Q000737:chemistry; D010936:Plant Extracts / Q000378:metabolism* / Q000494:pharmacology*; D018521:Plant Physiological Phenomena; D010940:Plant Proteins; D010944:Plants / Q000378:metabolism; D030821:Plants, Genetically Modified; D011401:Promoter Regions, Genetic; D011994:Recombinant Proteins / Q000737:chemistry; D012639:Seeds / Q000378:metabolism; D014026:Nicotiana / Q000235:genetics; D014612:Vaccines / Q000737:chemistry
D000906:Antibodies; D004364:Pharmaceutical Preparations; D010936:Plant Extracts; D010940:Plant Proteins; D011994:Recombinant Proteins; D014612:Vaccines