title: Viscocanalostomy with mitomycin-C: a preliminary study.
abstract: OBJECTIVE
  To compare the results of viscocanalostomy with and without mitomycin-C (MMC).
  
  
  METHODS
  Retrospective results of 15 standard viscocanalostomy (VCO) operations (Group 1) were compared with the prospective results of 15 VCO operations performed with intraoperative adjunctive MMC (Group 2). MMC (0.2 mg/mL) was applied over and under the superficial scleral flap for 3 minutes in Group 2 before the deep flap was prepared. Each patient was followed up for at least 1 year, and results of examinations in the first 12 months were used in the statistical comparison of the two groups. Surgical success was defined as intraocular pressure (IOP) < or = 18 mmHg.
  
  
  RESULTS
  Preoperative mean intraocular pressures (IOP) in Group 1 and Group 2 were 35.3+/-11.0 and 39.1+/-8.9, respectively. Mean IOP levels at the 12th month were 14.4+/-2.6 and 11.9+/-4.0, respectively, showing a significant decrease in both groups (p<0.001). Postoperative IOP course appeared to be lower in the MMC group, however, the difference was not statistically significant (p=0.554). Complete success rates without medications were 40% in Group 1 and 67% in Group 2. No significant difference was found between the two groups in terms of early and late postoperative complications, pre- and postoperative number of antiglaucoma medications, and surgical success rates at the end of the study period (p>0.05 for all). A significant difference was verified between the two groups of eyes considering the conjunctival bleb types, as low-lying, localized blebs were the most frequent type in Group 1 and thin-walled, avascular blebs were more predominant in the MMC group (p=0.004).
  
  
  CONCLUSIONS
  Intraoperative adjunctive MMC use might improve the long-term results of viscocanalostomy by facilitating subconjunctival filtration and might widen the indication range of the technique.
authors.affiliation: Ankara Numune Training and Research Hospital, 1st Eye Clinic, Ankara, Turkey. alperyx@yahoo.com
authors.forename: A
authors.initials: A
authors.lastname: Yarangümeli
authors.forename: O Gürbüz
authors.initials: OG
authors.lastname: Köz
authors.forename: M N
authors.initials: MN
authors.lastname: Alp
authors.forename: A H
authors.initials: AH
authors.lastname: Elhan
authors.forename: G
authors.initials: G
authors.lastname: Kural
mesh_terms: D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D005260:Female; D018463:Filtering Surgery / Q000379:methods*; D005902:Glaucoma, Open-Angle / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D007430:Intraoperative Care / Q000379:methods; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D011183:Postoperative Complications; D011446:Prospective Studies; D012189:Retrospective Studies; D012590:Sclera / Q000187:drug effects*; D013524:Surgical Flaps
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin