Snake Venom: Any Clue for Antibiotics and CAM?
Lately several naturally occurring peptides presenting antimicrobial activity have been described in the literature. However, snake venoms, which are an enormous source of peptides, have not been fully explored for searching such molecules. The aim of this work is to review the basis of antimicrobial mechanisms revealing snake venom as a feasible source for searching an antibiotic prototype. Therefore, it includes (i) a description of the constituents of the snake venoms involved in their main biological effects during the envenomation process; (ii) examples of snake venom molecules of commercial use; (iii) mechanisms of action of known antibiotics; and (iv) how the microorganisms can be resistant to antibiotics. This review also shows that snake venoms are not totally unexplored sources for antibiotics and complementary and alternative medicine (CAM).
de Lima
Deivy Clementino
DC
Alvarez Abreu
Paula
P
de Freitas
Cícero Carlos
CC
Santos
Dilvani Oliveira
DO
Borges
Rodrigo Oliveira
RO
Dos Santos
Tereza Cristina
TC
Mendes Cabral
Lúcio
L
Rodrigues
Carlos R
CR
Castro
Helena Carla
HC