[Tumour necrosis factor receptor-associated periodic syndrome. A rare differential diagnosis of multiple sclerosis].
Tumour necrosis factor receptor-associated periodic syndrome (TRAPS), a rare autosomal dominant disorder, is characterised by recurrent attacks of fever, myalgias, and abdominal pain. However, manifestations in the central nervous system are hardly known. We describe a family in which one of three affected members developed central nervous system symptoms. First diagnosed as multiple sclerosis (MS), the demyelinisation seems to be a feature of TRAPS rather than MS. The syndrome is discussed as a rare differential diagnosis of MS.
Günther
P
P
Klinik und Poliklinik für Neurologie, Universität Leipzig. peter.guenther@medizin.uni-leipzig.de
Minden
K
K
Hermann
W
W
Schneider
J-P
JP
Wagner
A
A
D000328:Adult; D003937:Diagnosis, Differential; D010505:Familial Mediterranean Fever / Q000175:diagnosis* / Q000235:genetics*; D005260:Female; D020279:Hereditary Central Nervous System Demyelinating Diseases / Q000175:diagnosis* / Q000235:genetics*; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000235:genetics; D035583:Rare Diseases / Q000175:diagnosis / Q000235:genetics; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics*; D013577:Syndrome
D018124:Receptors, Tumor Necrosis Factor