title: Endothelin levels in experimental diabetes combined with cardiac hypertrophy.
abstract: Diabetes mellitus is associated with endothelial and cardiac dysfunction, and endothelin has been suggested to alter cardiac function by being a positive inotropic agent, modulating the Frank-Starling response, contracting the coronary arteries and inducing tissue proliferation. We investigated endothelin levels in diabetic and in healthy dogs, 1 and 3 days after placing arteriovenous shunts (8 weeks after diabetes induction) in the femoral regions. Right and left ventricular weight/body weight ratios and Nterminal- atrial natriuretic peptide were increased in shunted animals (P < 0.05). Plasma endothelin levels were comparable in healthy and diabetic dogs. Shunted circulation did not change systemic endothelin levels in healthy dogs but reduced endothelin levels in diabetic dogs. The functional significance of altered endothelin responses to acute hemodynamic burden in experimental diabetes needs further investigation.
authors.affiliation: First Department of Internal Medicine, Semmelweis University, Budapest, Hungary. sreka78@hotmail.com
authors.forename: Réka
authors.initials: R
authors.lastname: Skoumal
authors.forename: Leila
authors.initials: L
authors.lastname: Seres
authors.forename: Pál
authors.initials: P
authors.lastname: Soós
authors.forename: Eva
authors.initials: E
authors.lastname: Balogh
authors.forename: Tìmea
authors.initials: T
authors.lastname: Kovàts
authors.forename: Jaana
authors.initials: J
authors.lastname: Rysa
authors.forename: Heikki
authors.initials: H
authors.lastname: Ruskoaho
authors.forename: Miklós
authors.initials: M
authors.lastname: Tóth
authors.forename: Ferenc
authors.initials: F
authors.lastname: Horkay
mesh_terms: D000818:Animals; D001166:Arteriovenous Shunt, Surgical; D009320:Atrial Natriuretic Factor / Q000097:blood; D001794:Blood Pressure; D006332:Cardiomegaly / Q000150:complications / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D004285:Dogs; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D008297:Male; D011498:Protein Precursors / Q000097:blood; D013997:Time Factors
chemical_list: D019332:Endothelin-1; C099254:N-terminal proatrial natriuretic peptide; D011498:Protein Precursors; D009320:Atrial Natriuretic Factor