Assessment of corticosteroid-induced alkaline phosphatase as a prognostic indicator in canine lymphoma.
OBJECTIVE
To examine the incidence of elevated corticosteroid-induced alkaline phosphatase (sALP) in dogs with lymphoma and to determine if sALP is a reliable prognostic indicator in canine lymphoma.


METHODS
The medical records of 62 canine lymphoma patients treated with a combination chemotherapy protocol from 1994 to 2003 at the University of Illinois Veterinary Teaching Hospital were examined. Variables assessed with respect to response rate and remission duration included age, bodyweight, sex, breed, World Health Organization stage (I to V), substage (a or b), pretreatment administration of corticosteroid, and serum levels of alkaline phosphatase, sALP and alanine aminotransferase.


RESULTS
sALP was not statistically significant with respect to response rate or duration of remission, nor was preinduction glucocorticoid administration. Stage was significant with respect to achieving remission.


CONCLUSIONS
It was found that sALP is not a useful prognostic indicator for response rate and remission duration in dogs with lymphoma.
Wiedemann
A L
AL
Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, 1008 West Hazelwood Drive, Urbana, IL 61802, USA.
Charney
S C
SC
Barger
A M
AM
Schaeffer
D J
DJ
Kitchell
B E
BE
D000305:Adrenal Cortex Hormones / Q000494:pharmacology; D000469:Alkaline Phosphatase / Q000096:biosynthesis / Q000097:blood* / Q000187:drug effects; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols; D015415:Biomarkers / Q000097:blood; D004283:Dog Diseases / Q000097:blood / Q000201:enzymology / Q000401:mortality*; D004285:Dogs; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D008223:Lymphoma / Q000097:blood / Q000201:enzymology / Q000401:mortality / Q000662:veterinary*; D008297:Male; D011379:Prognosis; D012074:Remission Induction; D012189:Retrospective Studies; D015996:Survival Rate
D000305:Adrenal Cortex Hormones; D015415:Biomarkers; D000469:Alkaline Phosphatase