Severity of Guillain-Barré syndrome is associated with Fc gamma Receptor III polymorphisms.
Macrophages and ganglioside-specific IgG are involved in the pathogenesis of Guillain-Barre syndrome (GBS). Leukocyte IgG receptors (Fc gammaR) confer potent cellular effector functions to the specificity of IgG. The efficacy of IgG-mediated cellular inflammatory responses is determined by functional polymorphisms of three Fc gammaR subclasses (Fc gammaRIIa: H131/R131; Fc gammaRIIIa: V158/F158; Fc gammaRIIIb: NA1/NA2). Fc gammaR genotype distributions were determined in a Dutch, and British cohort of GBS patients and controls. In addition, a meta-analysis incorporating all previously published data, encompassing a total of 345 GBS patients and 714 healthy controls, was performed. Results suggest that Fc gammaRIII genotypes may represent mild disease-modifying factors in GBS.
van Sorge
Nina M
NM
Department of Neurology G03.228, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
van der Pol
W-Ludo
WL
Jansen
Marc D
MD
Geleijns
Karin P W
KP
Kalmijn
Sandra
S
Hughes
Richard A C
RA
Rees
Jeremy H
JH
Pritchard
Jane
J
Vedeler
Christian A
CA
Myhr
Kjell-Morten
KM
Shaw
Chris
C
van Schaik
Ivo N
IN
Wokke
John H J
JH
van Doorn
Pieter A
PA
Jacobs
Bart C
BC
van de Winkel
Jan G J
JG
van den Berg
Leonard H
LH
D000328:Adult; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D020275:Guillain-Barre Syndrome / Q000235:genetics* / Q000503:physiopathology; D006801:Humans; D008297:Male; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011961:Receptors, Fc / Q000145:classification / Q000235:genetics*; D012189:Retrospective Studies; D044465:White People
D011961:Receptors, Fc