title: Multifocal motor neuropathy, type 1 diabetes and asymptomatic Hashimoto's thyroiditis: an unusual association.
abstract: Immune mediated mechanisms play a role in some forms of diabetic neuropathies. We studied a 17-year-old man who developed asymmetric weakness and atrophy in both upper arms soon after the diagnosis of type 1 diabetes. Nerve conduction studies demonstrated multifocal motor conduction blocks, and serological investigations revealed subclinical Hashimoto's thyroiditis. Therapy with intravenous immunoglobulin and cyclophosphamide led to clinical recovery. This is the first observation of an association between type 1 diabetes, multifocal motor neuropathy and Hashimoto's thyroiditis.
authors.affiliation: Neurology Department, Hospital Británico, Perdriel 74, Buenos Aires 1280, Argentina. rcreisin@intramed.net.ar
authors.forename: Ricardo C
authors.initials: RC
authors.lastname: Reisin
authors.forename: Cristina
authors.initials: C
authors.lastname: Zurrú
authors.forename: Carlos
authors.initials: C
authors.lastname: Buso
authors.forename: Cintia
authors.initials: C
authors.lastname: Marchesoni
authors.forename: Ana M
authors.initials: AM
authors.lastname: Pardal
authors.forename: Mauricio
authors.initials: M
authors.lastname: Jadzinsky
mesh_terms: D000293:Adolescent; D003520:Cyclophosphamide / Q000627:therapeutic use; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000628:therapy; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D016472:Motor Neuron Disease / Q000150:complications* / Q000628:therapy; D009407:Nerve Block / Q000379:methods; D009431:Neural Conduction / Q000502:physiology; D013967:Thyroiditis, Autoimmune / Q000150:complications* / Q000628:therapy
chemical_list: D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide