title: Electro-sensitisation of mammalian cells and tissues to ultrasound: a novel tumour treatment modality.
abstract: This study demonstrates that mammalian cell targets (erythrocytes and tumour cells) may be sensitised to ultrasound using electric pulses and this combination treatment results in destruction of those cells in vitro. It further demonstrates that when a tumour mass is treated in vivo using combined electric field and ultrasound therapy, significant retardation of tumour growth has been observed using a mouse tumour model. We suggest that combined electric field and ultrasound (CEFUS) therapy may provide a novel, drug-free treatment modality for cancer.
authors.affiliation: Gendel Ltd, Science Innovation Centre, University of Ulster, Coleraine, Co. Londonderry, BT52 1SA, Northern Ireland, UK.
authors.forename: A M
authors.initials: AM
authors.lastname: Rollan Haro
authors.forename: A
authors.initials: A
authors.lastname: Smyth
authors.forename: P
authors.initials: P
authors.lastname: Hughes
authors.forename: C N
authors.initials: CN
authors.lastname: Reid
authors.forename: A P
authors.initials: AP
authors.lastname: McHale
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D004599:Electric Stimulation Therapy; D004912:Erythrocytes / Q000000981:diagnostic imaging*; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000628:therapy*; D014464:Ultrasonic Therapy; D014463:Ultrasonography