title: [Effect of granulocyte-macrophage colony stimulating factor on the function and regeneration of myocardium in rats with experimental infarction].
abstract: To test the reparative capacity of stromal cells in myocardial infarction, rats were injected with granulocyte-monocyte-colony stimulating factor (GM-CSF) (leukomax), a cytokine known by its ability to raise a level of stromal cells in the blood, during first three days after coronary artery ligation. Only 10 of 17 rats (59%) survived 4 weeks in this group compared with 16 of 24 (67%) among rats not treated with leukomax. Echocardiographic and electromanometric studies showed that in both groups ventricular (LV) dilatation which developed during first hours after surgery persisted throughout 6-8 weeks and was combined with decreased ejection fraction and elevated LV end diastolic pressure. These alterations correlated with infarct size which varied from 0 to 28% of left ventricular weight in both groups. There were no statistically significant differences in functional and morphometric measurements between groups receiving and not receiving GM-CSF. However this result may be inconclusive due to small number of investigated animals and broad variation of ischemic zone size in each group.
authors.forename: V L
authors.initials: VL
authors.lastname: Lakomkin
authors.forename: R S
authors.initials: RS
authors.lastname: Aloev
authors.forename: N M
authors.initials: NM
authors.lastname: Cherpachenko
authors.forename: P V
authors.initials: PV
authors.lastname: Chumachenko
authors.forename: N V
authors.initials: NV
authors.lastname: Zakharova
authors.forename: V S
authors.initials: VS
authors.lastname: Zhdanov
authors.forename: O Iu
authors.initials: OIu
authors.lastname: At'kov
authors.forename: V I
authors.initials: VI
authors.lastname: Kapel'ko
mesh_terms: D000818:Animals; D002302:Cardiac Output / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D005500:Follow-Up Studies; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006321:Heart / Q000502:physiology*; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology*; D051381:Rats; D012038:Regeneration / Q000187:drug effects*; D016896:Treatment Outcome
chemical_list: D016178:Granulocyte-Macrophage Colony-Stimulating Factor