title: New cytotoxic sulfated saponins from the starfish Certonardoa semiregularis.
abstract: Two new sulfated saponins designated as certonardosides P2 and I3 (1 and 2) were isolated from the brine shrimp active fraction of the MeOH extract of the starfish Certonardoa semiregularis. The structures were determined on the basis of spectral analysis. Compounds 1 and 2 were tested for cytotoxicity against five human tumor cell lines (A549, SK-OV-3, SK-MEL-2, XF498, and HCT15), and compound 1 displayed significant cytotoxicity against the SK-MEL-2 skin cancer cell.
authors.affiliation: College of Pharmacy, Pusan National University, Busan 609-735, Korea.
authors.forename: Weihong
authors.initials: W
authors.lastname: Wang
authors.forename: Hyojin
authors.initials: H
authors.lastname: Jang
authors.forename: Jongki
authors.initials: J
authors.lastname: Hong
authors.forename: Chong-Ok
authors.initials: CO
authors.lastname: Lee
authors.forename: Song-Ja
authors.initials: SJ
authors.lastname: Bae
authors.forename: Sook
authors.initials: S
authors.lastname: Shin
authors.forename: Jee H
authors.initials: JH
authors.lastname: Jung
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013215:Starfish / Q000737:chemistry*; D013451:Sulfonic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D012503:Saponins; D013451:Sulfonic Acids; C502703:certonardoside P13; C502702:certonardoside P2