title: Genetic and biochemical strategies for identifying Drosophila genes that function in circadian control.
abstract: Explicit biochemical models have been elaborated for the circadian oscillators of cyanobacterial, fungal, insect, and mammalian species. In contrast, much remains to be learned about how such circadian oscillators regulate rhythmic physiological processes. This article summarizes contemporary genetic and biochemical strategies that are useful for identifying gene products that have a role in circadian control.
authors.affiliation: Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
authors.forename: F Rob
authors.initials: FR
authors.lastname: Jackson
authors.forename: Ginka K
authors.initials: GK
authors.lastname: Genova
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Huang
authors.forename: Yelena
authors.initials: Y
authors.lastname: Kleyner
authors.forename: Joowon
authors.initials: J
authors.lastname: Suh
authors.forename: Mary A
authors.initials: MA
authors.lastname: Roberts
authors.forename: Vasudha
authors.initials: V
authors.lastname: Sundram
authors.forename: Bikem
authors.initials: B
authors.lastname: Akten
mesh_terms: D000818:Animals; D001683:Biological Clocks / Q000187:drug effects* / Q000235:genetics; D001923:Brain Chemistry; D002940:Circadian Rhythm / Q000187:drug effects* / Q000235:genetics; D000242:Cyclic AMP / Q000378:metabolism; D017362:Cyclic AMP Response Element-Binding Protein / Q000502:physiology; D004268:DNA-Binding Proteins / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology; D004331:Drosophila melanogaster / Q000235:genetics; D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000235:genetics / Q000502:physiology; D017344:Genes, Insect / Q000502:physiology*; D007814:Larva / Q000502:physiology; D020935:MAP Kinase Signaling System / Q000502:physiology; D046228:Microarray Analysis / Q000379:methods; D009043:Motor Activity / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000502:physiology; D013493:Suprachiasmatic Nucleus / Q000502:physiology
chemical_list: D000242:Cyclic AMP; D017362:Cyclic AMP Response Element-Binding Protein; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D051860:Fragile X Messenger Ribonucleoprotein 1; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; C467328:FMR1 protein, Drosophila; C105214:Lark protein, Drosophila; C116191:e protein, Drosophila