Absolute configuration of kigamicins A, C and D.
The stereochemistry of kigamicins A (1), C (2) and D (3) were elucidated by a combination of X-ray crystallographic analysis and degradation studies. The absolute structures of kigamicins thus determined were depicted as shown in Fig. 2.
Someno
Tetsuya
T
Numazu Bio-Medical Research Institute, Microbial Chemistry Research Center, Numazu-shi, Shizuoka 410-0301, Japan. numazu@bikaken.or.jp
Kunimoto
Setsuko
S
Nakamura
Hikaru
H
Naganawa
Hiroshi
H
Ikeda
Daishiro
D
D018360:Crystallography, X-Ray; D004317:Doxorubicin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry*; D010080:Oxazoles / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D010080:Oxazoles; C484116:kigamicin A; C484114:kigamicin C; C484110:kigamicin D; D004317:Doxorubicin