In vivo effect of whole grain flour of finger millet (Eleusine coracana) and kodo millet (Paspalum scrobiculatum) on rat dermal wound healing.
Influence of finger millet and kodo millet on rat dermal wound healing was assessed by making a 4 cm2 (2 x 2 cm) excision wound on the shaven back of rats under ether anesthesia. Finger millet or kodo millet flour (300 mg) as aqueous paste was applied topically once daily for 16 days. The granulation tissue formed on day 4, 8 and 12 was used to estimate some biochemical parameters like protein, DNA, collagen and lipid peroxides. There was significant increase in protein and collagen contents and decrease in lipid peroxides. Biophysical parameters like rate of contraction and number of days for epithelialization were also studied. Rate of contraction was 88-90% in kodo millet and finger millet treated rats in comparison to 75% in untreated rats. The number of days for complete closure of wounds was lower for finger millet (13 days) and kodo millet (14 days) treated rats in comparison to untreated (16 days) rats. The results implicate a possible therapeutical role for finger millet and kodo millet in accelerating the process of wound healing.
Hegde
Prashant S
PS
Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600 036, India.
Anitha
B
B
Chandra
T S
TS
D000818:Animals; D003094:Collagen / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D031748:Eleusine / Q000378:metabolism*; D004848:Epithelium / Q000187:drug effects; D005433:Flour; D015227:Lipid Peroxidation; D008297:Male; D031781:Paspalum / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects*; D013997:Time Factors; D014945:Wound Healing
D003094:Collagen; D004247:DNA