Calciphylaxis: a rare complication of patients who required parathyroidectomy for advanced renal hyperparathyroidism.
Calciphylaxis is a relatively rare but life-threatening complication in uremic patients. Clinical findings and prognosis were evaluated in six patients who developed calciphylaxis from a group of 1499 patients who underwent parathyroidectomy (PTx) for advanced renal hyperparathyroidism (HPT) in our department from July 1972 to July 2003. The frequency of calciphylaxis was 0.40% (6/1499). Two patients were women and four were men. The mean age was 50.5 years, and the mean duration of hemodialysis (HD) treatment was 14.0 years. In five of six patients, calciphylaxis was classified as distal type; in one case, as proximal type. In three patients, calciphylaxis was diagnosed at the time for PTx. In two patients, calciphylaxis was identified after PTx, although the serum parathyroid hormone (PTH) level was within the appropriate range for dialysis patients. In two patients, calciphylaxis improved after PTx, but two patients required leg and toe amputations after PTx. In one patient with the proximal type of calciphylaxis, the condition occurred when a high PTH level recurred after the initial PTx. The patient died as a result of a serious infection due to uncontrollable skin ulcers. Calciphylaxis is a rare complication in patients who require PTx for renal HPT. Especially the proximal type has a poor prognosis. High levels of the Ca x P product and/or PTH are risk factors. Therefore, this syndrome should be kept in mind and attention should be paid to reduce risk factors. It is important that PTx being performed at the right time in patients with advanced renal HPT refractory to medical treatment.
Matsuoka
Susumu
S
Department of Surgery, Renal Center, Nagoya Second Red Cross Hospital, Nagoya University, 2-9 Myoken-cho, Showa-ku, Nagoya 466-8650, Japan. matsuoka@nagoya2.jrc.or.jp
Matstusoka
Susumu
S
Tominaga
Yoshihiro
Y
Uno
Nobuaki
N
Goto
Norihiko
N
Sato
Tetsuhiko
T
Katayama
Akio
A
Haba
Toshihito
T
Uchida
Kazuharu
K
Kobayashi
Keiko
K
Nakao
Akimasa
A
D000328:Adult; D002115:Calciphylaxis / Q000209:etiology*; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000150:complications* / Q000601:surgery*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016105:Parathyroidectomy; D014511:Uremia / Q000150:complications