Rapidly progressive IgA nephropathy.
A 14-year-old boy presented with macroscopic hematuria and a rapid deterioration in renal function. Percutaneous renal biopsy demonstrated severe crescentic IgA nephropathy (IgAN) with extensive (88%) glomerular crescent formation. After started intravenous administration of high-dose pulse methylprednisolone, severe nausea and general malaise accompanied by a rapid increase in Blood Urea Nitrogen (BUN) and serum creatinine levels appeared, however, the renal function ameliorated rapidly and fully recovered by following oral administration of corticosteroid. The clinical presentation of our case seems to be very remarkable compared to previously reported cases of rapidly progressive IgAN.
Kobayashi
Naho
N
Department of Pediatric Cardiology, University of Medicine Graduate School of Medical Science, Kyoto, Japan.
Nishida
Masashi
M
Aoyama
Michiko
M
Yokoi
Kentaro
K
Yahata
Tomoyo
T
Tatsujiro
Tatsujiro
T
Sakata
Koichi
K
Shiraishi
Isao
I
Itoi
Toshiyuki
T
Hamaoka
Kenji
K
D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D005922:Glomerulonephritis, IGA / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006417:Hematuria / Q000209:etiology; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D016482:Urinalysis
D000893:Anti-Inflammatory Agents; D003404:Creatinine; D008775:Methylprednisolone