title: Concise synthesis and antiviral activity of novel unsaturated acyclic pyrimidine nucleosides.
abstract: Novel acyclic nucleoside analogues were designed and synthesized as open-chain analogues of neplanocin A. The coupling of the allylic bromide with pyrimidine bases using cesium carbonate afforded a series of novel acyclic nucleosides. The synthesized compounds 15-22 were evaluated for their antiviral activity against various viruses such as HIV, HSV-1, HSV-2, and HCMV.
authors.affiliation: Medicinal Chemistry Research Center, Korea Institute of Science and Technology, Seoul, Republic of Korea.
authors.forename: Chang-Hyun
authors.initials: CH
authors.lastname: Oh
authors.forename: Tae-Rim
authors.initials: TR
authors.lastname: Baek
authors.forename: Joon Hee
authors.initials: JH
authors.lastname: Hong
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects*; D014780:Viruses
chemical_list: D000998:Antiviral Agents; D011741:Pyrimidine Nucleosides