Activation of cytotoxic lymphocytes in patients with scrub typhus.
Thai patients with scrub typhus caused by the intracellular pathogen Orientia tsutsugamushi displayed elevated plasma concentrations of granzymes A and B, interferon-gamma (IFN)-gamma-inducible protein 10, and monokine induced by IFN-gamma. These data suggest that activation of cytotoxic lymphocytes is part of the early host response to scrub typhus.
de Fost
Maaike
M
Laboratory of Experimental Internal Medicine and Department of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Chierakul
Wirongrong
W
Pimda
Kriangsak
K
Dondorp
Arjen M
AM
White
Nicholas J
NJ
Van der Poll
Tom
T
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D018925:Chemokines / Q000276:immunology; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D012612:Scrub Typhus / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D018925:Chemokines