title: Successful outcome of progressive multifocal leukoencephalopathy in a renal transplant patient.
abstract: We report the case of a 47-year-old man who developed progressive multifocal leukoencephalopathy (PML) after receiving immuno-suppressive therapy for renal transplantation. The patient presented with a focal seizure and cognitive changes 5 months post-transplantation. He was found to have enhancing lesions in the parietal lobe and typical findings of PML in a brain biopsy. Immunosuppression was discontinued and the neurological symptoms gradually resolved over a period of 4 weeks. The patient is free of any neurological symptoms 36 months after the diagnosis of PML and imaging studies demonstrate resolution of the PML lesions. The patient returned to hemodialysis 3 months after immunosuppression was discontinued. We also present a review of the literature on PML in renal transplant recipients.
authors.affiliation: Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
authors.forename: Clinton D
authors.initials: CD
authors.lastname: Crowder
authors.forename: Kymberly A
authors.initials: KA
authors.lastname: Gyure
authors.forename: Cinthia B
authors.initials: CB
authors.lastname: Drachenberg
authors.forename: Joseph
authors.initials: J
authors.lastname: Werner
authors.forename: Robert E
authors.initials: RE
authors.lastname: Morales
authors.forename: Hans H
authors.initials: HH
authors.lastname: Hirsch
authors.forename: Emilio
authors.initials: E
authors.lastname: Ramos
mesh_terms: D001706:Biopsy; D001921:Brain / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007577:JC Virus / Q000378:metabolism; D016030:Kidney Transplantation / Q000009:adverse effects*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000209:etiology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009394:Nephritis, Hereditary / Q000150:complications; D009836:Oligodendroglia / Q000378:metabolism; D011183:Postoperative Complications; D011379:Prognosis
chemical_list: D007166:Immunosuppressive Agents