title: Effects of histamine H3 receptor antagonists in two models of spatial learning.
abstract: Despite the well-described attention and short-term memory enhancing effects of H3 receptor antagonists, and evidence to suggest a close relationship between central histaminergic and cholinergic systems, there is a paucity of evidence for a role for H3 receptor blockade in spatial learning. To address this, we investigated two H3 receptor antagonists in a visual discrimination water maze in rats, and in a Barnes circular maze in mice. Thioperamide and ciproxifan significantly attenuated a scopolamine-induced deficit in the water maze task, while only ciproxifan showed a modest attenuation in the Barnes maze. Taken together, these data suggest a role for H3 receptors in spatial learning that appears to be task-dependent.
authors.affiliation: Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, AP9A, D4N5, Abbott Park, IL 60064, USA.
authors.forename: Victoria A
authors.initials: VA
authors.lastname: Komater
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Buckley
authors.forename: Kaitlin E
authors.initials: KE
authors.lastname: Browman
authors.forename: Jia Bao
authors.initials: JB
authors.lastname: Pan
authors.forename: Arthur A
authors.initials: AA
authors.lastname: Hancock
authors.forename: Michael W
authors.initials: MW
authors.lastname: Decker
authors.forename: Gerard B
authors.initials: GB
authors.lastname: Fox
mesh_terms: D000818:Animals; D003072:Cognition Disorders / Q000139:chemically induced; D004193:Discrimination Learning / Q000187:drug effects / Q000502:physiology*; D004924:Escape Reaction / Q000187:drug effects / Q000502:physiology*; D006633:Histamine Antagonists / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D023421:Models, Animal; D018727:Muscarinic Antagonists; D010880:Piperidines / Q000494:pharmacology; D051381:Rats; D020318:Rats, Long-Evans; D018100:Receptors, Histamine H3 / Q000187:drug effects / Q000502:physiology*; D012601:Scopolamine; D013037:Spatial Behavior / Q000187:drug effects / Q000502:physiology*
chemical_list: D006633:Histamine Antagonists; D007093:Imidazoles; D018727:Muscarinic Antagonists; D010880:Piperidines; D018100:Receptors, Histamine H3; C115705:ciproxifan; D012601:Scopolamine; C052075:thioperamide