Potential cellular receptors involved in hepatitis C virus entry into cells.
Hepatitis C virus (HCV) infects hepatocytes and leads to permanent, severe liver damage. Since the genomic sequence of HCV was determined, progress has been made towards understanding the functions of the HCV-encoded proteins and identifying the cellular receptor(s) responsible for adsorption and penetration of the virus particle into the target cells. Several cellular receptors for HCV have been proposed, all of which are associated with lipid and lipoprotein metabolism. This article reviews the cellular receptors for HCV and suggests a general model for HCV entry into cells, in which lipoproteins play a crucial role.
Favre
Daniel
D
Division of Gastroenterology and Hepatology, Department of Internal Medicine, University Hospital Zürich, Rämistrasse 100, CH-8091 Zürich, Switzerland. daniel.favre@usz.ch
Muellhaupt
Beat
B
D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D018955:CD36 Antigens / Q000378:metabolism; D005096:Exostoses / Q000378:metabolism; D016174:Hepacivirus / Q000378:metabolism*; D006801:Humans; D011973:Receptors, LDL / Q000378:metabolism; D011991:Receptors, Virus / Q000378:metabolism*; D060225:Tetraspanin 28
D015703:Antigens, CD; D018955:CD36 Antigens; C554798:CD81 protein, human; D011973:Receptors, LDL; D011991:Receptors, Virus; D060225:Tetraspanin 28