title: Structural characteristics of activated carbons and ibuprofen adsorption affected by bovine serum albumin.
abstract: Structural characteristics of a series of MAST carbons were studied using scanning electron microscopy images and the nitrogen adsorption isotherms analyzed with several models of pores and different adsorption equations. A developed model of pores as a mixture of gaps between spherical nanoparticles and slitlike pores was found appropriate for MAST carbons. Adsorption of ibuprofen [2-(4-isobutylphenyl)propionic acid] on activated carbons possessing different pore size distributions in protein-free and bovine serum albumin (BSA)-containing aqueous solutions reveals the importance of the contribution of mesopores to the total porosity of adsorbents. The influence of the mesoporosity increases when considering the removal of the drug from the protein-containing solution. Cellulose-coated microporous carbon Norit RBX adsorbs significantly smaller amounts of ibuprofen than uncoated micro/mesoporous MAST carbons whose adsorption capability increases with increasing mesoporosity and specific surface area, burnoff dependent variable. A similar effect of broad pores is observed on adsorption of fibrinogen on the same carbons. Analysis of the ibuprofen adsorption data using Langmuir and D'Arcy-Watt equations as the kernel of the Fredholm integral equation shows that the nonuniformity of ibuprofen adsorption complexes diminishes with the presence of BSA. This effect may be explained by a partial adsorption of ibuprofen onto protein molecules immobilized on carbon particles and blocking of a portion of narrow pores.
authors.affiliation: School of Pharmacy and Biomolecular Sciences, University of Brighton, Lewes Road, Brighton BN2 4GJ, UK.
authors.forename: M
authors.initials: M
authors.lastname: Melillo
authors.forename: V M
authors.initials: VM
authors.lastname: Gun'ko
authors.forename: S R
authors.initials: SR
authors.lastname: Tennison
authors.forename: L I
authors.initials: LI
authors.lastname: Mikhalovska
authors.forename: G J
authors.initials: GJ
authors.lastname: Phillips
authors.forename: J G
authors.initials: JG
authors.lastname: Davies
authors.forename: A W
authors.initials: AW
authors.lastname: Lloyd
authors.forename: O P
authors.initials: OP
authors.lastname: Kozynchenko
authors.forename: D J
authors.initials: DJ
authors.lastname: Malik
authors.forename: M
authors.initials: M
authors.lastname: Streat
authors.forename: S V
authors.initials: SV
authors.lastname: Mikhalovsky
mesh_terms: D000327:Adsorption; D000818:Animals; D002244:Carbon / Q000737:chemistry*; D002417:Cattle; D006801:Humans; D007052:Ibuprofen / Q000737:chemistry*; D008958:Models, Molecular; D009584:Nitrogen / Q000737:chemistry; D012709:Serum Albumin / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D012709:Serum Albumin; D012710:Serum Albumin, Bovine; D002244:Carbon; D009584:Nitrogen; D007052:Ibuprofen