Catalytic synthesis of tricyclic quinoline derivatives from the regioselective hydroamination and C-H bond activation reaction of benzocyclic amines and alkynes.
The cationic ruthenium-hydride complex [(PCy3)2(CO)(CH3CN)2RuH]+BF4- (1) was found to be an effective catalyst for the regioselective coupling reaction of benzocyclic amines and terminal alkynes to form the tricyclic quinoline derivatives. The scope of the reaction was explored by using the catalytic system Ru3(CO)12/NH4PF6. The catalytically active cationic ruthenium-acetylide complex [(PCy3)2(CO)(CH3CN)2RuCCPh]+BF4- was isolated from the reaction of 1 with phenylacetylene.
Yi
Chae S
CS
Department of Chemistry, Marquette University, Milwaukee, Wisconsin 53201-1881, USA. chae.yi@marquette.edu
Yun
Sang Young
SY
Guzei
Ilia A
IA
D000480:Alkynes / Q000737:chemistry*; D000586:Amination; D000588:Amines / Q000737:chemistry*; D001555:Benzene Derivatives / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D011804:Quinolines / Q000138:chemical synthesis*; D012428:Ruthenium / Q000737:chemistry
D000480:Alkynes; D000588:Amines; D001555:Benzene Derivatives; D009942:Organometallic Compounds; D011804:Quinolines; D012428:Ruthenium