title: Immunohistochemical demonstration of connexin-related epithelization defects in a lamb caused by (erythro)keratodermia variabilis.
abstract: The distribution of four important connexins (Cx 26, 30, 31, 43) in the skin of a neonatal lamb with (erythro)keratodermia (EKV) was demonstrated using immunohistochemistry, including a very sensitive visualization system. The reaction staining for Cx 26, 30 and 31 was negative to weak in all skin structures, and only Cx 43 displayed weak to moderate positive reactions, although not uniformly distributed throughout the important systems (e.g. epidermis, hair follicle sheaths). Thus, the study proves for the first time that connexin defects are associated with the development of EKV in domesticated mammals, as they are in humans.
authors.affiliation: Anatomical Institute, School of Veterinary Medicine Hannover, Germany. wilfried.meyer@tiho-hannover.de
authors.forename: W
authors.initials: W
authors.lastname: Meyer
authors.forename: A
authors.initials: A
authors.lastname: Wehrend
authors.forename: A
authors.initials: A
authors.lastname: Schnapper
authors.forename: H
authors.initials: H
authors.lastname: Bostedt
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000906:Antibodies / Q000032:analysis; D017630:Connexins / Q000032:analysis*; D003873:Dermatitis, Exfoliative / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D004890:Erythema / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D017809:Fatal Outcome; D005260:Female; D005808:Genes, Recessive; D007150:Immunohistochemistry / Q000662:veterinary; D007642:Keratosis / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000235:genetics / Q000473:pathology*; D012867:Skin / Q000166:cytology / Q000473:pathology
chemical_list: D000906:Antibodies; D017630:Connexins