Cellular and molecular gateways to urolithiasis: a new insight.
Urolithiasis is a relevant clinical problem in everyday practice with a subsequent burden for the health system. Urolithiasis is classically explained as the derangement in the process of biomineralization involving the equilibrium between promoters and inhibitors of crystallization: a deficit of one or several inhibitors or an excess of one or several promoters plays a pivotal role in the stone formation. The revolutionary introduction of the molecular biology in medicine has given a new insight in urolithiasis too. Genetic factors have also been postulated to play an important role. A review of the current knowledge on urolithiasis based upon a molecular and genetic approach is reported.
Dal Moro
Fabrizio
F
Department of Urology, Padova Medical School, University of Padova, Padova, Italy.
Mancini
Mariangela
M
Tavolini
Ivan Matteo
IM
De Marco
Vincenzo
V
Bassi
Pierfrancesco
P
D000818:Animals; D017209:Apoptosis; D001693:Biological Transport, Active / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D003460:Crystallization; D003545:Cysteine / Q000378:metabolism; D006801:Humans; D017616:Magnesium Compounds / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism; D000069877:Struvite; D014527:Uric Acid / Q000378:metabolism; D014545:Urinary Calculi / Q000378:metabolism* / Q000473:pathology*
D017616:Magnesium Compounds; D010710:Phosphates; D014527:Uric Acid; D000069877:Struvite; D003545:Cysteine; D002118:Calcium