title: Cowden disease: CT findings in three patients.
abstract: Cowden disease, also known as multiple hamartoma syndromes, is an autosomal dominant disease characterized by numerous benign mucocutaneous tumors, hamartomas of multiple organs, and malignancies of the breast and thyroid. In this report, we present the computed tomographic findings in three patients with Cowden disease. In addition to the classic findings, the patients were diagnosed with spinal neurinoma (n=1), meningioma (n=1), and hepatic hemangioma (n=3). We also review current clinical and genetic concepts that unify Cowden disease.
authors.affiliation: Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors.forename: J
authors.initials: J
authors.lastname: Rademaker
authors.forename: Y J
authors.initials: YJ
authors.lastname: Kim
authors.forename: T
authors.initials: T
authors.lastname: Leibecke
authors.forename: S S
authors.initials: SS
authors.lastname: Raman
authors.forename: C
authors.initials: C
authors.lastname: Voit
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D004386:Duodenum / Q000000981:diagnostic imaging; D005260:Female; D005500:Follow-Up Studies; D006223:Hamartoma Syndrome, Multiple / Q000000981:diagnostic imaging*; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging; D008168:Lung / Q000000981:diagnostic imaging; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed