title: YM-216391, a novel cytotoxic cyclic peptide from Streptomyces nobilis. II. Physico-chemical properties and structure elucidation.
abstract: YM-216391, a novel cytotoxic cyclic peptide, has been isolated from the cultured mycelium of Streptomyces nobilis JCM 4274. The planar structure of YM-216391 was assigned on the basis of 1D and 2D NMR spectroscopic techniques. The absolute configuration of the amino acid residues in YM-216391 was determined by Marfey's analysis and chiral HPLC analysis of its acid hydrolysate.
authors.affiliation: Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Itabashi-ku, Tokyo 174-8511, Japan. souda@yamanouchi.co.jp
authors.forename: Kin-ya
authors.initials: KY
authors.lastname: Sohda
authors.forename: Masashi
authors.initials: M
authors.lastname: Hiramoto
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Suzumura
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Takebayashi
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Suzuki
authors.forename: Akihiro
authors.initials: A
authors.lastname: Tanaka
mesh_terms: D000970:Antineoplastic Agents / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010080:Oxazoles / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification; D010456:Peptides, Cyclic / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification; D013302:Streptomyces
chemical_list: D000970:Antineoplastic Agents; D010080:Oxazoles; D010456:Peptides, Cyclic; C499972:YM 216391