Reduced-intensity unrelated cord blood transplantation for patients with advanced malignant lymphoma.
We report the results of reduced-intensity unrelated cord blood transplantation (RI-UCBT) in patients with advanced malignant lymphoma. Twenty patients (median age, 46.5 years; range, 27-66 years) underwent RI-UCBT with a preparative regimen consisting of fludarabine 125 mg/m2 , melphalan 80 mg/m 2 , and 4 Gy of total body irradiation. The median infused total cell dose was 2.75 x 10(7)/kg (range, 2.3-3.4 x 10(7)/kg). Graft-versus-host disease (GVHD) prophylaxis was composed of cyclosporine or tacrolimus alone. Fifteen patients achieved primary neutrophil engraftment after a median of 20 days. Eight patients developed grade II to IV acute GVHD, and 2 developed chronic GVHD. Of the 16 patients with evaluable disease, 10 achieved a complete response. Primary disease recurred in 1 patient, and transplant-related mortality within 100 days occurred in 8 of 20 patients. The estimated 1-year probability of progression-free survival was 50%. These data suggest that RI-UCBT is a feasible option for patients with refractory lymphoma who lack an HLA-matched donor.
Yuji
Koichiro
K
Department of Hematology, Toranomon Hospital, Toranomon, Tokyo, Japan.
Miyakoshi
Shigesaburo
S
Kato
Daisuke
D
Miura
Yuji
Y
Myojo
Tomohiro
T
Murashige
Naoko
N
Kishi
Yukiko
Y
Kobayashi
Kazuhiro
K
Kusumi
Eiji
E
Narimatsu
Hiroto
H
Hamaki
Tamae
T
Matsumura
Tomoko
T
Kami
Masahiro
M
Fukuda
Takahiro
T
Masuo
Shigeru
S
Masuoka
Kazuhiro
K
Wake
Atsushi
A
Ueyama
Junichi
J
Yoneyama
Akiko
A
Miyamoto
Ko
K
Nagoshi
Haruhisa
H
Matsuzaki
Michio
M
Morinaga
Shinichi
S
Muto
Yoshitomo
Y
Takeue
Yoichi
Y
Taniguchi
Shuichi
S
D000328:Adult; D000368:Aged; D036101:Cord Blood Stem Cell Transplantation; D018572:Disease-Free Survival; D005260:Female; D006086:Graft vs Host Disease / Q000401:mortality / Q000517:prevention & control*; D006650:Histocompatibility Testing; D006801:Humans; D008223:Lymphoma / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D019172:Transplantation Conditioning / Q000379:methods; D014916:Whole-Body Irradiation