Effect of nifedipine and amlodipine on dead space wound healing in rats.
Effect of two calcium channel blockers (CCBs) nifedipine and amlodipine, was studied on normal and steroid depressed wound healing in albino rats, using the dead space wound model. The drugs enhanced normal healing as evidenced by increase in tensile strength of 10 days old granulation tissue. There was neither a significant change in the hydroxyproline level (or collagen) nor a change in the glycosaminoglycan content in granulation tissue. However, lysyloxidase level was increased significantly. The increase in tensile strength could thus be attributed to better cross-linking and maturation of collagen rather than collagen synthesis per se. The drugs were also able to overcome steroid depressed wound healing. It is likely that the prohealing effects may be related to the improved antioxidant status too, since superoxide dismutase levels were observed to be higher in the CCB- treated animals.
Bhaskar
H N
HN
Department of Pharmacology, Melaka-Manipal Medical College, KMC, MAHE Manipal 576 104, India. bhaskar712001@hotmail.com
Udupa
Saraswathi L
SL
Udupa
A L
AL
D017311:Amlodipine / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology; D006025:Glycosaminoglycans / Q000378:metabolism; D006595:Hexosamines / Q000378:metabolism; D006603:Hexuronic Acids / Q000378:metabolism; D006909:Hydroxyproline / Q000378:metabolism; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D008249:Protein-Lysine 6-Oxidase / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013256:Steroids / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D013718:Tensile Strength; D014665:Vasodilator Agents / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects*
D000975:Antioxidants; D002121:Calcium Channel Blockers; D006025:Glycosaminoglycans; D006595:Hexosamines; D006603:Hexuronic Acids; D013256:Steroids; D014665:Vasodilator Agents; D017311:Amlodipine; D013482:Superoxide Dismutase; D008249:Protein-Lysine 6-Oxidase; D009543:Nifedipine; D006909:Hydroxyproline