NF-kappaB as a molecular target in adjuvant therapy of gastrointestinal carcinomas.
OBJECTIVE
To describe the role of nuclear factor-kappa B (NF-kappaB) in cancer treatment.


METHODS
We searched the Pubmed database (until Oct, 2004) with the keywords of gastrointestinal carcinoma, NF-kappaB, inhibitor, cancer treatment molecular target and chemoresistance. We reviewed the literature in the role of NF-kappaB activation in chemoresistance, tumour growth suppression and enhancement of apoptosis in gastrointestinal carcinomas.


CONCLUSIONS
Several possible strategies for inhibiting NF-kappaB activation are identified. The importance of targeting NF-kappaB as a potential therapeutic approach in clinical medicine was discussed.
Yu
Y Y
YY
Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China. yingyan3y@yahoo.com.cn
Li
Q
Q
Zhu
Z G
ZG
D000970:Antineoplastic Agents / Q000494:pharmacology; D017024:Chemotherapy, Adjuvant; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy* / Q000378:metabolism*; D006801:Humans; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000502:physiology*
D000970:Antineoplastic Agents; D016328:NF-kappa B