Plasticizer di(2-ethylhexyl)phthalate (DEHP) release in wet-primed extracorporeal membrane oxygenation (ECMO) circuits.
A wet-primed ready-to-use extracorporeal membrane oxygenation (ECMO) circuit is used in some centres for rapid deployment of ECMO during cardiopulmonary resuscitation. Yet, the potential release of plasticizer di(2-ethylhexyl)phthalate (DEHP) from the polyvinyl chloride tubing in the circuit during storage is a concern. In this study, a high performance liquid chromatography method was used to determine the concentration of DEHP in the priming solution (Plasmalyte) from an ECMO circuit stored for up to 14 days at 8 degrees C. No accumulation of DEHP in the circulating fluid was detected. The results provide important information for centres where ECMO circuits are kept wet-primed prior to clinical use.
Han
Jihong
J
Centre for Paediatric Pharmacy Research, School of Pharmacy, University of London, 29/39 Brunswick Square, London WC1N 1AX, UK.
Beeton
Allison
A
Long
Paul
P
Karimova
Ann
A
Robertson
Alex
A
Cross
Nigel
N
Smith
Liz
L
O'Callaghan
Maura
M
Goldman
Allan
A
Brown
Kate
K
Tuleu
Catherine
C
D004051:Diethylhexyl Phthalate / Q000032:analysis* / Q000378:metabolism; D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects / Q000379:methods*; D010968:Plasticizers / Q000032:analysis* / Q000378:metabolism
D010968:Plasticizers; D004051:Diethylhexyl Phthalate