title: Unusual clinical presentation of brucellosis caused by Brucella canis.
abstract: Brucella canis is considered a rare cause of human brucellosis. The clinical importance of this infection may have been underestimated so far because of difficulties with presumptive diagnosis. The case described here presented symptoms compatible with brucellosis but the routine tests using Brucella abortus antigen were negative. The infection would have remained undiagnosed if culture had not been positive. This case illustrates the potential for a favourable outcome in Brucella canis diagnosis and supports recommendations for the use of B. canis serology. The infection should be suspected in patients with compatible symptoms and negative serology for B. abortus antigen.
authors.affiliation: Brucellosis Laboratory, Administración Nacional de Laboratorios e Institutos de Salud Dr C. G. Malbrán (ANLIS), Avda. Velez Sarsfield 563, 1281 Buenos Aires, Argentina 2Unidad de Transplante Renal, Hospital Cosme Argerich, Margall 750, 1155 Buenos Aires, Argentina 3Hospital Naval 'Pedro Mallo', Patricias Argentinas 351, 1405 Buenos Aires, Argentina 4Laboratoire de Pathologie Infectieuse et Immunologie, Institut National de la Recherche Agronomique, 37380 Nouzilly, France.
authors.forename: Nidia E
authors.initials: NE
authors.lastname: Lucero
authors.affiliation: Brucellosis Laboratory, Administración Nacional de Laboratorios e Institutos de Salud Dr C. G. Malbrán (ANLIS), Avda. Velez Sarsfield 563, 1281 Buenos Aires, Argentina 2Unidad de Transplante Renal, Hospital Cosme Argerich, Margall 750, 1155 Buenos Aires, Argentina 3Hospital Naval 'Pedro Mallo', Patricias Argentinas 351, 1405 Buenos Aires, Argentina 4Laboratoire de Pathologie Infectieuse et Immunologie, Institut National de la Recherche Agronomique, 37380 Nouzilly, France.
authors.forename: Nestor O
authors.initials: NO
authors.lastname: Jacob
authors.affiliation: Brucellosis Laboratory, Administración Nacional de Laboratorios e Institutos de Salud Dr C. G. Malbrán (ANLIS), Avda. Velez Sarsfield 563, 1281 Buenos Aires, Argentina 2Unidad de Transplante Renal, Hospital Cosme Argerich, Margall 750, 1155 Buenos Aires, Argentina 3Hospital Naval 'Pedro Mallo', Patricias Argentinas 351, 1405 Buenos Aires, Argentina 4Laboratoire de Pathologie Infectieuse et Immunologie, Institut National de la Recherche Agronomique, 37380 Nouzilly, France.
authors.forename: Sandra M
authors.initials: SM
authors.lastname: Ayala
authors.affiliation: Brucellosis Laboratory, Administración Nacional de Laboratorios e Institutos de Salud Dr C. G. Malbrán (ANLIS), Avda. Velez Sarsfield 563, 1281 Buenos Aires, Argentina 2Unidad de Transplante Renal, Hospital Cosme Argerich, Margall 750, 1155 Buenos Aires, Argentina 3Hospital Naval 'Pedro Mallo', Patricias Argentinas 351, 1405 Buenos Aires, Argentina 4Laboratoire de Pathologie Infectieuse et Immunologie, Institut National de la Recherche Agronomique, 37380 Nouzilly, France.
authors.forename: Gabriela I
authors.initials: GI
authors.lastname: Escobar
authors.affiliation: Brucellosis Laboratory, Administración Nacional de Laboratorios e Institutos de Salud Dr C. G. Malbrán (ANLIS), Avda. Velez Sarsfield 563, 1281 Buenos Aires, Argentina 2Unidad de Transplante Renal, Hospital Cosme Argerich, Margall 750, 1155 Buenos Aires, Argentina 3Hospital Naval 'Pedro Mallo', Patricias Argentinas 351, 1405 Buenos Aires, Argentina 4Laboratoire de Pathologie Infectieuse et Immunologie, Institut National de la Recherche Agronomique, 37380 Nouzilly, France.
authors.forename: Patricia
authors.initials: P
authors.lastname: Tuccillo
authors.affiliation: Brucellosis Laboratory, Administración Nacional de Laboratorios e Institutos de Salud Dr C. G. Malbrán (ANLIS), Avda. Velez Sarsfield 563, 1281 Buenos Aires, Argentina 2Unidad de Transplante Renal, Hospital Cosme Argerich, Margall 750, 1155 Buenos Aires, Argentina 3Hospital Naval 'Pedro Mallo', Patricias Argentinas 351, 1405 Buenos Aires, Argentina 4Laboratoire de Pathologie Infectieuse et Immunologie, Institut National de la Recherche Agronomique, 37380 Nouzilly, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Jacques
mesh_terms: D000293:Adolescent; D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology; D041002:Brucella canis / Q000276:immunology* / Q000302:isolation & purification; D002006:Brucellosis / Q000175:diagnosis* / Q000453:epidemiology; D003429:Cross Reactions; D004285:Dogs; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D008297:Male; D012699:Serology; D013045:Species Specificity
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D007106:Immune Sera