title: Recent developments in chemotherapy of advanced gastric cancer.
abstract: Approximately 1 million individuals develop gastric cancer every year and the mortality of gastric cancer is only second to lung cancer. The poor prognosis is caused by late diagnosis of most cancers in advanced stages and the limited therapeutic options in these stages. Apart from the elucidation of underlying molecular and genetic changes in the development and progression of gastric cancers, the development of new treatment strategies is critical for the improvement of the treatment and prognosis of these patients. In this review we have summarized and critically assessed recent studies dealing with the chemotherapy of advanced gastric cancer. While the efficacy of most treatment regimens is only limited, new developments may indicate that treatment with chemotherapy may confer some benefit in the future.
authors.affiliation: Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University Magdeburg, Magdeburg, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Götze
authors.forename: Kerstin
authors.initials: K
authors.lastname: Schütte
authors.forename: Christoph
authors.initials: C
authors.lastname: Röcken
authors.forename: Peter
authors.initials: P
authors.lastname: Malfertheiner
authors.forename: Matthias P A
authors.initials: MP
authors.lastname: Ebert
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006801:Humans; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents