title: Arterial pressure and heart rate increase during REM sleep in adenosine A2A-receptor knockout mice, but not in wild-type mice.
abstract: Rapid eye movement (REM)-sleep related changes in arterial pressure (AP) and heart rate (HR) were observed in homozygous and heterozygous adenosine A(2A) receptor (A2AR) knockout (KO) mice, and the corresponding wild-type mice. During REM sleep, the mean AP (MAP) and HR were clearly increased in the homozygous A2AR KO mice, while, in the wild-type mice, they were decreased or maintained at the same level. Neither homozygous nor heterozygous A2AR KO mice showed significant difference in diurnal pattern and the hourly values of MAP and HR compared to the wild-type mice. From these findings, it is likely that the adenosine A2AR is involved in autonomic regulation during REM sleep.
authors.affiliation: Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan.
authors.forename: Mie
authors.initials: M
authors.lastname: Sakata
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Sei
authors.forename: Naomi
authors.initials: N
authors.lastname: Eguchi
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Morita
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Urade
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology*; D004569:Electroencephalography / Q000379:methods; D006339:Heart Rate / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout / Q000502:physiology; D043705:Receptor, Adenosine A2A / Q000172:deficiency* / Q000235:genetics / Q000502:physiology; D012895:Sleep, REM / Q000235:genetics / Q000502:physiology*; D013057:Spectrum Analysis
chemical_list: D043705:Receptor, Adenosine A2A