title: Severity of Guillain-Barré syndrome is associated with Fc gamma Receptor III polymorphisms.
abstract: Macrophages and ganglioside-specific IgG are involved in the pathogenesis of Guillain-Barre syndrome (GBS). Leukocyte IgG receptors (Fc gammaR) confer potent cellular effector functions to the specificity of IgG. The efficacy of IgG-mediated cellular inflammatory responses is determined by functional polymorphisms of three Fc gammaR subclasses (Fc gammaRIIa: H131/R131; Fc gammaRIIIa: V158/F158; Fc gammaRIIIb: NA1/NA2). Fc gammaR genotype distributions were determined in a Dutch, and British cohort of GBS patients and controls. In addition, a meta-analysis incorporating all previously published data, encompassing a total of 345 GBS patients and 714 healthy controls, was performed. Results suggest that Fc gammaRIII genotypes may represent mild disease-modifying factors in GBS.
authors.affiliation: Department of Neurology G03.228, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
authors.forename: Nina M
authors.initials: NM
authors.lastname: van Sorge
authors.forename: W-Ludo
authors.initials: WL
authors.lastname: van der Pol
authors.forename: Marc D
authors.initials: MD
authors.lastname: Jansen
authors.forename: Karin P W
authors.initials: KP
authors.lastname: Geleijns
authors.forename: Sandra
authors.initials: S
authors.lastname: Kalmijn
authors.forename: Richard A C
authors.initials: RA
authors.lastname: Hughes
authors.forename: Jeremy H
authors.initials: JH
authors.lastname: Rees
authors.forename: Jane
authors.initials: J
authors.lastname: Pritchard
authors.forename: Christian A
authors.initials: CA
authors.lastname: Vedeler
authors.forename: Kjell-Morten
authors.initials: KM
authors.lastname: Myhr
authors.forename: Chris
authors.initials: C
authors.lastname: Shaw
authors.forename: Ivo N
authors.initials: IN
authors.lastname: van Schaik
authors.forename: John H J
authors.initials: JH
authors.lastname: Wokke
authors.forename: Pieter A
authors.initials: PA
authors.lastname: van Doorn
authors.forename: Bart C
authors.initials: BC
authors.lastname: Jacobs
authors.forename: Jan G J
authors.initials: JG
authors.lastname: van de Winkel
authors.forename: Leonard H
authors.initials: LH
authors.lastname: van den Berg
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D020275:Guillain-Barre Syndrome / Q000235:genetics* / Q000503:physiopathology; D006801:Humans; D008297:Male; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011961:Receptors, Fc / Q000145:classification / Q000235:genetics*; D012189:Retrospective Studies; D044465:White People
chemical_list: D011961:Receptors, Fc