Anti-fertility effects of embelin in female Sprague-Dawley rats may be due to suppression of ovarian function.
Effects of embelin on oestrous cycle, plasma levels of progesterone and oestradiol, and in vitro production of oestradiol and progesterone by mixed ovarian cells was studied. Forty adult (4 months old) regularly cycling female Sprague-Dawley rats were divided into four groups of 10 rats each. Groups I and II (controls) were given 1 ml/kg body weight of physiological saline or corn oil (vehicle). Groups III and IV received 10 mg/kg and 20 mg/kg body weight embelin in corn oil, respectively. Emberlin disrupted the oestrous cycles in Groups III and IV animals, and there was a significant depression in plasma oestradiol (p <0.05) and progesterone (p <0.02) at both 10 and 20 mg/kg body weights, respectively. Isolated mixed ovarian cells from embelin treated rats produced significantly less progesterone and estradiol than controls in vitro. It is concluded that embelin probably interferes with reproductive functions in female rats by suppressing ovarian production of sex steroid hormones.
Wango
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Department of Animal Physiology, University of Nairobi, Nairobi, Kenya. wango@uonbi.ac.ke
D000818:Animals; D016227:Benzoquinones / Q000494:pharmacology*; D001835:Body Weight; D003276:Contraceptives, Oral / Q000494:pharmacology; D004967:Estrogens / Q000378:metabolism; D004971:Estrus / Q000187:drug effects*; D005260:Female; D005298:Fertility / Q000187:drug effects*; D010053:Ovary / Q000187:drug effects* / Q000378:metabolism; D011374:Progesterone / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D016227:Benzoquinones; D003276:Contraceptives, Oral; D004967:Estrogens; D011374:Progesterone; C010945:embelin