title: Modeling wave propagation in realistic heart geometries using the phase-field method.
abstract: We present a novel algorithm for modeling electrical wave propagation in anatomical models of the heart. The algorithm uses a phase-field approach that represents the boundaries between the heart muscle and the surrounding medium as a spatially diffuse interface of finite thickness. The chief advantage of this method is to automatically handle the boundary conditions of the voltage in complex geometries without the need to track the location of these boundaries explicitly. The algorithm is shown to converge accurately in nontrivial test geometries with no-flux (zero normal current) boundary conditions as the width of the diffuse interface becomes small compared to the width of the cardiac action potential wavefront. Moreover, the method is illustrated for anatomically realistic models of isolated rabbit and canine ventricles as well as human atria.
authors.affiliation: Department of Physics, Hofstra University, Hempstead, New York 11549 and Beth Israel Medical Center, New York, NY 10003, USA.
authors.forename: Flavio H
authors.initials: FH
authors.lastname: Fenton
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Cherry
authors.forename: Alain
authors.initials: A
authors.lastname: Karma
authors.forename: Wouter-Jan
authors.initials: WJ
authors.lastname: Rappel
mesh_terms: D000200:Action Potentials; D000465:Algorithms; D000818:Animals; D003198:Computer Simulation; D004285:Dogs; D004594:Electrophysiology; D006321:Heart / Q000033:anatomy & histology*; D006325:Heart Atria / Q000033:anatomy & histology* / Q000473:pathology*; D006329:Heart Conduction System; D006801:Humans; D008953:Models, Anatomic; D008955:Models, Cardiovascular; D015233:Models, Statistical; D008962:Models, Theoretical; D011817:Rabbits; D012984:Software; D013997:Time Factors