title: Evidence based guidelines for the prevention, identification, and management of occupational asthma.
abstract: BACKGROUND
  Occupational asthma is the most frequently reported work related respiratory disease in many countries. This work was commissioned by the British Occupational Health Research Foundation to assist the Health and Safety Executive in achieving its target of reducing the incidence of occupational asthma in Great Britain by 30% by 2010.
  
  
  OBJECTIVE
  The guidelines aim to improve the prevention, identification, and management of occupational asthma by providing evidence based recommendations on which future practice can be based.
  
  
  METHODS
  The literature was searched systematically using Medline and Embase for articles published in all languages up to the end of June 2004. Evidence based statements and recommendations were graded according to the Royal College of General Practitioner's star system and the revised Scottish Intercollegiate Guidelines Network grading system.
  
  
  RESULTS
  A total of 474 original studies were selected for appraisal from over 2500 abstracts. The systematic review produced 52 graded evidence statements and 22 recommendations based on 223 studies.
  
  
  CONCLUSIONS
  Evidence based guidelines have become benchmarks for practice in healthcare and the process used to prepare them is well established. This evidence review and its recommendations focus on interventions and outcomes to provide a robust approach to the prevention, identification, and management of occupational asthma, based on and using the best available medical evidence. The most important action to prevent cases of occupational asthma is to reduce exposure at source. Thereafter surveillance should be performed for the early identification of symptoms, including occupational rhinitis, with additional functional and immunological tests where appropriate. Effective management of workers suspected to have occupational asthma involves the identification and investigation of symptoms suggestive of asthma immediately they occur. Those workers who are confirmed to have occupational asthma should be advised to avoid further exposure completely and early in the course of their disease to offer the best chance of recovery.
authors.affiliation: Procter & Gamble, Whitehall Lane, Egham, Surrey, UK. nicholson.pj@pg.com
authors.forename: P J
authors.initials: PJ
authors.lastname: Nicholson
authors.forename: P
authors.initials: P
authors.lastname: Cullinan
authors.forename: A J Newman
authors.initials: AJ
authors.lastname: Taylor
authors.forename: P S
authors.initials: PS
authors.lastname: Burge
authors.forename: C
authors.initials: C
authors.lastname: Boyle
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000633:toxicity; D001249:Asthma / Q000175:diagnosis / Q000517:prevention & control* / Q000628:therapy; D019317:Evidence-Based Medicine; D006801:Humans; D009784:Occupational Diseases / Q000175:diagnosis / Q000517:prevention & control* / Q000628:therapy; D016273:Occupational Exposure / Q000009:adverse effects / Q000517:prevention & control; D011159:Population Surveillance / Q000379:methods; D017410:Practice Guidelines as Topic; D011379:Prognosis; D012220:Rhinitis / Q000150:complications / Q000517:prevention & control; D012307:Risk Factors; D006113:United Kingdom
chemical_list: D000395:Air Pollutants, Occupational