title: The effect of calcium channel blockers on outcome following the surgical treatment of phaeochromocytomas and paragangliomas.
abstract: The peri-operative management of patients undergoing surgery for phaeochromocytoma or paraganglioma with calcium channel blockers (CCB) and their impact on postoperative morbidity and mortality were studied. The medical records of 105 patients undergoing surgery between 1991 and 2002 were analysed retrospectively. In all patients, the calcium channel blocker nicardipine was used for the peri-operative management of haemodynamic changes. Sixty-five patients (61.9%) showed transient intra-operative hypertension. Systolic blood pressure (SBP) > 220 mmHg and SBP > 180 mmHg for > 10 consecutive minutes was observed in 14 (13%) and four patients (2.8%), respectively. SBP < 80 mmHg for > 10 consecutive minutes occurred in 13 patients (12.3%). Eleven patients (10.4%) developed postoperative complications and three patients died (2.8%). The median (range) ICU and hospital length of stay were, respectively, 1 (0-7) day and 10 (2-35) days. The sole use of calcium channel blockers for the peri-operative management of phaeochromocytoma and paraganglioma resection does not prevent all haemodynamic changes; however, its use was associated with a low morbidity and mortality.
authors.affiliation: Department of Anaesthesiology and Intensive Care, Huriez Hospital, University Hospital of Lille, France. g-lebuffe@chru-lille.fr <g-lebuffe@chru-lille.fr>
authors.forename: G
authors.initials: G
authors.lastname: Lebuffe
authors.forename: E D
authors.initials: ED
authors.lastname: Dosseh
authors.forename: G
authors.initials: G
authors.lastname: Tek
authors.forename: H
authors.initials: H
authors.lastname: Tytgat
authors.forename: S
authors.initials: S
authors.lastname: Moreno
authors.forename: B
authors.initials: B
authors.lastname: Tavernier
authors.forename: B
authors.initials: B
authors.lastname: Vallet
authors.forename: C A G
authors.initials: CA
authors.lastname: Proye
mesh_terms: D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000503:physiopathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D002648:Child; D003422:Critical Care; D004334:Drug Administration Schedule; D006801:Humans; D007902:Length of Stay; D008875:Middle Aged; D009529:Nicardipine / Q000627:therapeutic use; D010235:Paraganglioma / Q000503:physiopathology / Q000601:surgery*; D010673:Pheochromocytoma / Q000503:physiopathology / Q000601:surgery*; D011183:Postoperative Complications / Q000517:prevention & control*; D011229:Preanesthetic Medication; D012189:Retrospective Studies; D013223:Statistics as Topic
chemical_list: D002121:Calcium Channel Blockers; D009529:Nicardipine