Prognostic impact of aortic calcification index and ankle-arm blood pressure index in patients under hemodialysis.
The mortality rate is high in patients receiving hemodialysis (HD), atherosclerotic diseases being the major cause of death. As marker of clinical outcome, a prospective examination of atherosclerotic tests and atherosclerotic risk factors in patients receiving HD was performed. On April 2000, 84 patients receiving HD were followed up until April 2002. At entry to the study, several atherosclerotic tests, including ankle-arm blood pressure index (API), aortic calcification index (ACI), and atherosclerotic risk factors, were performed. In 36 patients with old thrombotic events, 26 had new thrombotic events. Of 48 patients without previous thrombotic events, 15 had new thrombotic events. During 2 years, 41 patients had new thrombotic events and 15 patients died due to thrombotic disorders. The HD durations were significantly longer in non-survivors than survivors and the body mass index was lower in non-survivors than survivors. There was a significant difference in the values of ACI and API between survivors and non-survivors, and between patients with and without thrombotic events. These findings suggest that the ACI and API have a prognostic value because they might predict the occurrence of thrombosis.
Kushiya
Fumihiko
F
Second Department of Internal Medicine, Mie University School of Medicine, Tsu-city, Mie-Ken, Japan.
Wada
Hideo
H
Sakakura
Miho
M
Mori
Yoshitaka
Y
Gabazza
Esteban C
EC
Nishikawa
Masakatsu
M
Nobori
Tsutomu
T
Noguchi
Mitsuya
M
Izumi
Kazuo
K
Nakasaki
Takahiro
T
Takagi
Mikio
M
Shiku
Hiroshi
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000842:Ankle / Q000502:physiology*; D001011:Aorta / Q000473:pathology* / Q000503:physiopathology*; D001132:Arm / Q000502:physiology*; D001161:Arteriosclerosis / Q000473:pathology; D015415:Biomarkers; D001794:Blood Pressure / Q000502:physiology*; D002114:Calcinosis; D005260:Female; D006490:Hemostatics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D006435:Renal Dialysis; D015996:Survival Rate
D015415:Biomarkers; D006490:Hemostatics