Total synthesis of (+)-cyanthiwigin U.
A concise total synthesis of the tricyclic terpene cyanthiwigin U has been accomplished in 12 steps and 17% overall yield. The key step of the synthesis is a two-directional tandem metathesis reaction that forms the cyclohepta[e]indene core from a readily available bicyclo[2.2.2]octene.
Pfeiffer
Matthew W B
MW
Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309-0215, USA.
Phillips
Andrew J
AJ
D004224:Diterpenes / Q000138:chemical synthesis*; D013237:Stereoisomerism
D004224:Diterpenes; C501253:cyanthiwigin U