title: Serum carotenoids and other antioxidative substances associated with urothelial cancer risk in a nested case-control study in Japanese men.
abstract: OBJECTIVE
  We assayed whether high serum carotenoids and antioxidative substances decrease the risk of urothelial cancer in a case-control study nested in a community based cohort in Japan, that is the Japan Collaborative Cohort Study.
  
  
  METHODS
  Information on subject life-styles and serum were collected in 1988 to 1990 and subjects were followed as late as 1999. Individuals who had or died of urothelial cancer and controls were matched for study area, sex and age. Serum was stored at -80C and analyzed in 2003. Of 14,097 male and 25,662 female subjects 40 to 79 years old there were 42 cases, which were matched to 124 controls.
  
  
  RESULTS
  The OR for the highest to lowest tertile of serum concentration was 0.28 (95% CI 0.07 to 1.15, trend p = 0.08) for beta-carotene, 0.36 (95% CI 0.10 to 1.27, trend p = 0.10) for total carotenes and 0.31 (95% CI 0.09 to -1.09, trend p = 0.09) for total carotenoids after adjustment for smoking in addition to matching variables. High concentrations of tocopherols and xanthophylls slightly tended to decrease the risk of urothelial cancer. In contrast, serum retinol, oxidized low density lipoprotein and Cu/Zn-superoxide dismutase were not associated with urothelial cancer risk.
  
  
  CONCLUSIONS
  Our results suggest that high serum carotenoids may decrease the risk of urothelial cancer with carotenes more effective than xanthophylls.
authors.affiliation: Department of Epidemiology for Community Health and Medicin, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan. kozasa@koto.kpu-m.ac.jp
authors.forename: Kotaro
authors.initials: K
authors.lastname: Ozasa
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Ito
authors.forename: Koji
authors.initials: K
authors.lastname: Suzuki
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Kyohei
authors.initials: K
authors.lastname: Hayashi
authors.forename: Kazuya
authors.initials: K
authors.lastname: Mikami
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nakao
authors.forename: Tsuneharu
authors.initials: T
authors.lastname: Miki
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Mori
authors.forename: Fumio
authors.initials: F
authors.lastname: Sakauchi
authors.forename: Masakazu
authors.initials: M
authors.lastname: Washio
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Kubo
authors.forename: Kenji
authors.initials: K
authors.lastname: Wakai
authors.forename: Akiko
authors.initials: A
authors.lastname: Tamakoshi
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000032:analysis*; D002338:Carotenoids / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D012306:Risk; D014571:Urologic Neoplasms / Q000097:blood*; D019459:Urothelium
chemical_list: D000975:Antioxidants; D002338:Carotenoids