title: Management of an advanced ovarian cancer at 15 weeks of gestation: case report and literature review.
abstract: BACKGROUND
  To report a case of advanced ovarian carcinoma diagnosed during gestation, which was managed with conservative surgery and chemotherapy until delivery.
  
  
  METHODS
  The patient underwent bilateral salpingo-oophorectomy, omentectomy, and appendectomy at 15 weeks of gestation. Six courses of chemotherapy with cisplatin were administered. Cesarean section followed by total hysterectomy were performed at 36 weeks of gestation. The male infant was 3000 g, Apgar score 9/9. Twenty-four months after delivery, the patient experienced pelvic recurrence and underwent surgery and six cycles of carboplatin and paclitaxel. The patient is alive with no evidence of disease. After 42 months of follow-up, the baby boy showed no evidence of sequelae.
  
  
  CONCLUSIONS
  Medical and surgical management of ovarian cancer during pregnancy can be an option, although the risks and benefits have to be discussed with caution.
authors.affiliation: Gynecologic Oncology Unit, Catholic University of Rome, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Ferrandina
authors.forename: Mariagrazia
authors.initials: M
authors.lastname: Distefano
authors.forename: Antonia
authors.initials: A
authors.lastname: Testa
authors.forename: Rosa
authors.initials: R
authors.lastname: De Vincenzo
authors.forename: Giovanni
authors.initials: G
authors.lastname: Scambia
mesh_terms: D000328:Adult; D002945:Cisplatin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy* / Q000601:surgery*; D011256:Pregnancy Outcome
chemical_list: D002945:Cisplatin