title: CNS siderosis and dandy-walker variant after neonatal alloimmune thrombocytopenia.
abstract: This report presents a case of superficial siderosis of the central nervous system secondary to repeated intraventricular and subarachnoid bleeding of a newborn infant with neonatal alloimmune thrombocytopenia. In addition, this infant manifested Dandy-Walker variant. To date, the few known cases of superficial siderosis in neonates have not been associated with neonatal alloimmune thrombocytopenia or Dandy-Walker complex. We believe that repeated bleeding in the central nervous system from early fetal life, especially in the posterior fossa, may produce cerebellar atrophy as occurs in adults with superficial siderosis of the central nervous system.
authors.affiliation: University Hospital of Canary Islands, University of La Laguna, La Laguna, S/C Tenerife, Spain.
authors.forename: José Ramón
authors.initials: JR
authors.lastname: Castro Conde
authors.forename: Eduardo Doménech
authors.initials: ED
authors.lastname: Martínez
authors.forename: Raúl Cabrera
authors.initials: RC
authors.lastname: Rodríguez
authors.forename: Ana Lorena
authors.initials: AL
authors.lastname: Rodríguez De Hoyos
mesh_terms: D002531:Cerebellum / Q000002:abnormalities; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D003616:Dandy-Walker Syndrome / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D012806:Siderosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D013921:Thrombocytopenia / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D014463:Ultrasonography