title: Food allergen sensitization in inner-city children with asthma.
abstract: BACKGROUND
  Asthma continues to be an increasing cause of morbidity in the pediatric population, and studies have shown an association between food sensitivity and asthma.
  
  
  OBJECTIVE
  We investigated the degree of food allergen sensitization in inner-city patients with asthma.
  
  
  METHODS
  Five hundred four random serum samples from the National Cooperative Inner City Asthma Study were evaluated for specific IgE (UniCap) to 6 common food allergens (egg, milk, soy, peanut, wheat, and fish). Statistical analyses were performed to determine food sensitization prevalence and its association with asthma morbidity.
  
  
  RESULTS
  Forty-five percent of patients had evidence of sensitization (food-specific IgE > or = 0.35 kU/L) to at least 1 food. Nineteen percent had IgE levels at > or = 50% positive predictive value for clinical reactivity to at least 1 food, with 4% of patients having levels > 95% positive predictive value for food allergy. Children sensitized to foods had higher rates of asthma hospitalization (P < .01) and required more steroid medications (P = .025). Sensitization to foods also correlated with sensitization to more indoor and outdoor aeroallergens (P < .001).
  
  
  CONCLUSIONS
  Food allergen sensitization is highly prevalent in the inner-city population with asthma, and it is associated with increased asthma healthcare and medication use. Therefore, food allergen sensitivity may be a marker for increased asthma severity.
authors.affiliation: Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai Hospital, New York, NY, USA.
authors.forename: Julie
authors.initials: J
authors.lastname: Wang
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Visness
authors.forename: Hugh A
authors.initials: HA
authors.lastname: Sampson
mesh_terms: D000818:Animals; D000918:Antibody Specificity; D010367:Arachis / Q000276:immunology; D001249:Asthma / Q000453:epidemiology* / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D004781:Environmental Exposure / Q000032:analysis; D005399:Fishes / Q000276:immunology; D005512:Food Hypersensitivity / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D006760:Hospitalization; D006801:Humans; D007114:Immunization; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D008892:Milk / Q000276:immunology; D009017:Morbidity; D010063:Ovum / Q000276:immunology; D012307:Risk Factors; D013025:Glycine max / Q000276:immunology; D014908:Triticum / Q000276:immunology; D014481:United States; D014505:Urban Population
chemical_list: D007073:Immunoglobulin E