5-HT2A and muscarinic receptors in schizophrenia: a postmortem study.
Although evidence suggests that 5-HT(2A) and muscarinic M1/M4 receptors are implicated in the pathology of schizophrenia, the results are not conclusive. In the present study we tested the hypothesis that binding of 5-HT(2A) and M1/M4 receptors is altered in the postmortem brain of schizophrenia subjects. Quantitative autoradiography was employed to measure [(3)H]ketanserin binding to 5-HT(2A) receptors and [(3)H]pirenzepine binding to both M1 and M4 receptors in Brodmann's area 9 (BA9), caudate/putamen, and the hippocampal formation from six schizophrenic and six control subjects. A significant reduction in the density of 5HT(2A) receptors in BA 9 of schizophrenic subjects was observed (p=0.036). No significant difference was observed in the density of 5HT(2A) receptors in the hippocampus or caudate/putamen between the two groups. No significant changes in the density of M1/M4 receptors was observed in these three regions between the two groups. These findings support a possible involvement of the serotonergic system in the pathology of schizophrenia.
Matsumoto
Izuru
I
Department of Pathology, University of Sydney, NSW 2006, Australia. izuru@med.usyd.edu.au
Inoue
Yuki
Y
Iwazaki
Takeshi
T
Pavey
Geoff
G
Dean
Brian
B
D000368:Aged; D000369:Aged, 80 and over; D001345:Autoradiography / Q000379:methods; D001921:Brain / Q000378:metabolism / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007650:Ketanserin / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000494:pharmacology; D010890:Pirenzepine / Q000494:pharmacology; D011180:Postmortem Changes; D011485:Protein Binding / Q000187:drug effects / Q000502:physiology; D044402:Receptor, Serotonin, 5-HT2A / Q000378:metabolism*; D011976:Receptors, Muscarinic / Q000378:metabolism*; D012559:Schizophrenia / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000494:pharmacology; D014316:Tritium / Q000494:pharmacology
D018727:Muscarinic Antagonists; D044402:Receptor, Serotonin, 5-HT2A; D011976:Receptors, Muscarinic; D012702:Serotonin Antagonists; D014316:Tritium; D010890:Pirenzepine; D007650:Ketanserin