Highly enantioselective conjugate addition of nitromethane to chalcones using bifunctional cinchona organocatalysts.
Cinchona alkaloid-derived chiral bifunctional thiourea organocatalysts were synthesized and applied in the Michael addition between nitromethane and chalcones with high ee and chemical yields.
Vakulya
Benedek
B
Institute of Biomolecular Chemistry, Chemical Research Center of Hungarian Academy of Sciences, Budapest.
Varga
Szilárd
S
Csámpai
Antal
A
Soós
Tibor
T
D002384:Catalysis; D047188:Chalcones / Q000737:chemistry*; D002929:Cinchona / Q000737:chemistry; D002930:Cinchona Alkaloids / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D009595:Nitroparaffins / Q000737:chemistry*; D013237:Stereoisomerism; D013890:Thiourea / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry
D047188:Chalcones; D002930:Cinchona Alkaloids; D009595:Nitroparaffins; D013890:Thiourea; D008697:Methane; C008640:nitromethane