[Some parameters of immune response in patients infected with Toxoplasma gondii].
The immune system, its cellular and humoral response, is engaged by the host organism to fight against parasitic invasions. The group examined consisted of 52 women aged 18-42 years infected with Toxoplasma gondii. The diagnosis was established based on serologic examination. Blood for analysis was collected before antiparasitic treatment. Control group consisted of 32 healthy women aged 18-46 years. The concentrations of IgM, IgG and IgE were assayed using a set of VIDAS (bioMerieux) and the concentrations of IL-5 were assayed using a set of Quantikine human IL-5 (R&D Systems). An abnormal rise in total serum IgE can be observed in parasitosis and allergy. IL-5 is produced mainly in T-cells in response to stimulation by parasite-derived antigens and allergens The present study revealed that (in toxoplasmosis) the concentration of IgE and IL-5 contents in blood serum was higher 2-times, respectively than in healthy controls.
Matowicka-Karna
Joanna
J
Zakład Laboratoryjnej Diagnostyki Klinicznej Akademii Medycznej w Białymstoku.
Kemona
Halina
H
Dymicka-Piekarska
Violetta
V
D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007136:Immunoglobulins / Q000097:blood*; D015848:Interleukin-5 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014123:Toxoplasmosis / Q000276:immunology*
D015415:Biomarkers; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D015848:Interleukin-5; D007073:Immunoglobulin E