Treatment of bias in estimating measurement uncertainty.
Bias in an analytical measurement should be estimated and corrected for, but this is not always done. As an alternative to correction, there are a number of methods that increase the expanded uncertainty to take account of bias. All sensible combinations of correcting or enlarging uncertainty for bias, whether considered significant or not, were modeled by a Latin hypercube simulation of 125,000 iterations for a range of bias values. The fraction of results for which the result and its expanded uncertainty contained the true value of a simulated test measure and was used to assess the different methods. The strategy of estimating the bias and always correcting is consistently the best throughout the range of biases. For expansion of the uncertainty when the bias is considered significant is best done by SUMU(Max):U(C(test result))=ku(c)(C(test result))+ |delta(run)|, where k is the coverage factor (= 2 for 95% confidence interval), u(c) is the combined standard uncertainty of the measurement and delta(run) is the run bias.
O'Donnell
Gregory E
GE
School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.
Hibbert
D Brynn
DB
D015982:Bias; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D003627:Data Interpretation, Statistical; D003657:Decision Making; D009626:Terminology as Topic; D035501:Uncertainty