title: Acute fatty liver of pregnancy complicated with disseminated intravascular coagulation and haemorrhage: a case report.
abstract: Acute fatty liver of pregnancy (AFLP) is a rare disorder of unknown aetiology that is diagnosed typically in the third trimester or early postpartum period. The incidence is estimated to be 1/6692-1/13,328. The obstetric team must have a high index of suspicion of this pathology, particularly in the presence of clinical and laboratory findings, such as nausea, vomiting, jaundice, increased serum transaminase levels, increased prothrombin time and hypoglycaemia. Early diagnosis followed by prompt delivery and supportive care provides significantly improved maternal and perinatal outcome. Delay in diagnosis of this obstetric emergency may lead to rapid progression to hepatic failure, disseminated intravascular coagulation (DIC), haemorrhage, encephalopathy, multiple organ failure and finally death. The case of a 34-year-old woman, gravida 3, para 2, with AFLP complicated with DIC is presented herein with a review of literature and discussion of its origin.
authors.affiliation: Department of Obstetrics and Gynecology, University of Kocaeli, School of Medicine, Kocaeli, Turkey. gulserene@superonline.com
authors.forename: G
authors.initials: G
authors.lastname: Yücesoy
authors.forename: S O
authors.initials: SO
authors.lastname: Ozkan
authors.forename: H
authors.initials: H
authors.lastname: Bodur
authors.forename: Y
authors.initials: Y
authors.lastname: Cakiroğlu
authors.forename: E
authors.initials: E
authors.lastname: Calişkan
authors.forename: S
authors.initials: S
authors.lastname: Ozeren
mesh_terms: D000208:Acute Disease; D000328:Adult; D004211:Disseminated Intravascular Coagulation / Q000209:etiology*; D005234:Fatty Liver / Q000150:complications*; D005260:Female; D006801:Humans; D006473:Postpartum Hemorrhage / Q000209:etiology*; D011247:Pregnancy; D011248:Pregnancy Complications