Synthesis of polycyclic aromatics and heteroaromatics via electrophilic cyclization.
[reaction: see text] A variety of substituted polycyclic aromatics are readily prepared in good to excellent yields under very mild reaction conditions by the reaction of 2-(1-alkynyl)biphenyls with ICl, I(2), NBS, and p-O(2)NC(6)H(4)SCl. This methodology readily accommodates various functional groups and has been successfully extended to systems containing a variety of polycyclic and heterocyclic rings.
Yao
Tuanli
T
Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.
Campo
Marino A
MA
Larock
Richard C
RC
D002384:Catalysis; D003500:Cyclization; D006576:Heterocyclic Compounds, 4 or More Rings / Q000032:analysis / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis / Q000138:chemical synthesis*
D006576:Heterocyclic Compounds, 4 or More Rings; D007202:Indicators and Reagents; D011084:Polycyclic Aromatic Hydrocarbons; D010165:Palladium