title: Ziprasidone: a novel psychotropic with unique properties.
abstract: Ziprasidone (Geodon) is a relatively new atypical antipsychotic medication with a unique pharmacological profile. It is indicated for the treatment of schizophrenia, but has also often been used off-label for other uses. This review summarizes its important properties, specifically the pharmacodynamic parameters, receptor-binding profile and relevance to clinical outcomes, side effects, and potential for drug-drug interactions and established clinical indications. Novel therapeutic applications and relevant clinical trials or reports are also examined. The authors review the current market and speculate on likely changes in 5 years.
authors.affiliation: PEEC, Ground Floor, Ravdin Building, 3400 Spruce St., Philadelphia, PA 19104, USA. christosballas@yahoo.com
authors.forename: Christos
authors.initials: C
authors.lastname: Ballas
authors.forename: Calvin
authors.initials: C
authors.lastname: Yang
authors.forename: John
authors.initials: J
authors.lastname: O'Reardon
authors.forename: Paul
authors.initials: P
authors.lastname: Ballas
authors.forename: Claudia
authors.initials: C
authors.lastname: Baldassano
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic / Q000639:trends; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy* / Q000378:metabolism; D010879:Piperazines / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D012559:Schizophrenia / Q000188:drug therapy / Q000378:metabolism; D013844:Thiazoles / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D014150:Antipsychotic Agents; D010879:Piperazines; D013844:Thiazoles; C092292:ziprasidone