title: Optimisation and use of water-in-oil MEEKC in pharmaceutical analysis.
abstract: Water-in-oil microemulsion electrokinetic chromatography has been applied to the separation of a range of acids, bases and neutrals and is especially suitable for very water-insoluble drug compounds. A number of operating parameters were evaluated. An optimised set of operating conditions allowed separation of a range of pharmaceutical formulations containing water-insoluble compounds. A number of novel applications for W/O microemulsions were developed and ability to quantify drug contents in tablets and a cream was shown with good precision, detector linearity and accuracy. Comparison of obtained data with those determined from a HPLC method showed acceptable agreement.
authors.affiliation: Waterford Institute of Technology, Department of Chemical and Life Sciences, Cork Road, Waterford, Ireland. mbroderick@wit.ie
authors.forename: Margo
authors.initials: M
authors.lastname: Broderick
authors.forename: Sheila
authors.initials: S
authors.lastname: Donegan
authors.forename: Joe
authors.initials: J
authors.lastname: Power
authors.forename: Kevin
authors.initials: K
authors.lastname: Altria
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods*; D004563:Electrochemistry; D004655:Emulsions / Q000032:analysis* / Q000737:chemistry; D009821:Oils / Q000032:analysis / Q000737:chemistry; D014867:Water / Q000032:analysis / Q000737:chemistry
chemical_list: D004655:Emulsions; D009821:Oils; D014867:Water