Acute transient cerebral toxicity associated with administration of high-dose methotrexate.
OBJECTIVE
To report the first case of transient central nervous system toxicity after administration of high-dose methotrexate (HDMTX) in the Middle East.


METHODS
A 10-year-old boy was diagnosed with osteosarcoma of the proximal end of the left tibia. He underwent primary amputation and was started on adjuvant chemotherapy, which included administration of HDMTX. He developed acute cerebral toxicity after the 5th dose of HDMTX in the form of diplopia, seizures and disorientation. He recovered completely without any complication or neurological sequelae.


CONCLUSIONS
The acute cerebral toxicity associated with HDMTX was completely reversible and without any sequelae.
Mittal
Rakesh
R
Department of Medical Oncology, Hussain Maki Al Juma Centre for Specialized Surgeries, Shuwaikh, Kuwait. rakeshmittal55@hotmail.com
Mottl
Hubert
H
Nemec
Jaroslav
J
D000208:Acute Disease; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D001859:Bone Neoplasms / Q000188:drug therapy; D002540:Cerebral Cortex / Q000187:drug effects*; D002648:Child; D003221:Confusion / Q000139:chemically induced; D004172:Diplopia / Q000139:chemically induced; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D020258:Neurotoxicity Syndromes / Q000209:etiology*; D012516:Osteosarcoma / Q000188:drug therapy; D012640:Seizures / Q000139:chemically induced; D013977:Tibia / Q000473:pathology; D013997:Time Factors
D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate