Effect of perductal paclitaxel exposure on the development of MNU-induced mammary carcinoma in female S-D rats.
BACKGROUND
Breast carcinoma and precancer are thought to start in the lining of the milk duct or lobule.


METHODS
At 5weeks of age, rats received a intraperitoneal (ip) injection of MNU for carcinogenesis. After mammary tumors were identified macroscopically using fiberscope, the rats were treated with perductal (pd) or ip injection of paclitaxel tri-weekly. At 36 weeks after MNU injection, tumor burden (No. of >1cm palpable mammary tumors/rat), total number of mammary carcinoma, apoptosis (AI), and microvessel density (MVD) were measured.


RESULTS
The administration of paclitaxel through the duct did not produce any toxic side effect. The tumor burden and total number of mammary carcinoma in the pd paclitaxel-treated group were significantly reduced compared to those seen in the ip paclitaxel-treated group. In addition, in the pd paclitaxel-treated group, AI was also increased and MVD was decreased, compared to those in the ip paclitaxel-treated group.


CONCLUSIONS
Local administration of paclitaxel may be useful for treatment of breast cancer.
Okugawa
Homa
H
Department of Surgery, Kansai Medical University, Moriguchi, Osaka, 570-8506, Japan.
Yamamoto
Daigo
D
Uemura
Yoshiko
Y
Sakaida
Noriko
N
Tanano
Akihide
A
Tanaka
Kanji
K
Kamiyama
Yasuo
Y
D000477:Alkylating Agents / Q000008:administration & dosage; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D007263:Infusions, Parenteral; D008321:Mammary Glands, Animal; D015674:Mammary Neoplasms, Animal / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D008325:Mammary Neoplasms, Experimental; D008770:Methylnitrosourea / Q000008:administration & dosage; D017239:Paclitaxel / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000477:Alkylating Agents; D000972:Antineoplastic Agents, Phytogenic; D008770:Methylnitrosourea; D017239:Paclitaxel