Synthesis of optically pure 1,2-diaryl- and 1,2-alkylaryl-1,2-amino sulfides.
[reaction: see text] The reactions of the lithium (S)-alpha-(methylthio)-2-(p-toluenesulfinyl)benzyl carbanion with (S)-N-p-tolylsulfinyl aldimines evolve in a completely stereoselective manner providing a one-step synthesis of enantiomerically pure anti-1,2-disubstituted 1,2-amino sulfide derivatives.
Arroyo
Yolanda
Y
Departamento de Química Orgánica (ETSII), Universidad de Valladolid, Po. del Cauce s/n, 47011 Valladolid, Spain.
Meana
Angela
A
Rodríguez
J Félix
JF
Santos
Mercedes
M
Sanz-Tejedor
M Ascensión
MA
García Ruano
José L
JL