title: A sero-epidemiological survey of gelatin sensitization in young Japanese children during the 1979-1996 period.
abstract: Recently, an increasing number of adverse reactions in children inoculated with live attenuated virus vaccines containing gelatin have been reported. However, the distribution, magnitude and rate of gelatin sensitization in the Japanese population have not been established. Here, the purpose was to investigate the distribution of children with positive gelatin immunoglobulin G (IgG) and/or IgE in Japan and to ascertain whether the incidence of positive antigelatin antibody cases among the general population, as reflected in the sample employed here, has been increasing during the period in question. The presence of IgE and IgG antibodies were measured against gelatin in 1600 panel sera collected from different age groups of Japanese children in Hokkaido/Sapporo from 1979 through 1996. Among the subjects, 39 had gelatin IgG- and/or IgE-positive sera, and these were correlated with the time of obtaining the sera as well as with the age of the subjects. The older the subject and the later the period, the higher the sero-incidence. Japanese children have become increasingly sensitized to gelatin, especially since the mid-1990s.
authors.affiliation: Hokkaido Institute of Public Health, Sapporo, Hokkaido, Japan. saitoak@iph.pref.hokkaido.jp
authors.forename: A
authors.initials: A
authors.lastname: Saito
authors.forename: T
authors.initials: T
authors.lastname: Kumagai
authors.forename: H
authors.initials: H
authors.lastname: Kojima
authors.forename: I
authors.initials: I
authors.lastname: Terai
authors.forename: T
authors.initials: T
authors.lastname: Yamanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Wataya
authors.forename: M
authors.initials: M
authors.lastname: Umetsu
authors.forename: A
authors.initials: A
authors.lastname: Umetsu
authors.forename: S
authors.initials: S
authors.lastname: Yano
mesh_terms: D002675:Child, Preschool; D004342:Drug Hypersensitivity / Q000453:epidemiology / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005512:Food Hypersensitivity / Q000453:epidemiology* / Q000276:immunology*; D005780:Gelatin / Q000009:adverse effects* / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D012189:Retrospective Studies; D016036:Seroepidemiologic Studies; D014613:Vaccines, Attenuated / Q000009:adverse effects / Q000276:immunology; D014765:Viral Vaccines / Q000009:adverse effects / Q000276:immunology
chemical_list: D007074:Immunoglobulin G; D014613:Vaccines, Attenuated; D014765:Viral Vaccines; D007073:Immunoglobulin E; D005780:Gelatin