title: Oxygen-enhanced proton imaging of the human lung using T2.
abstract: Magnetic susceptibility gradients caused by tissue/air interfaces lead to very short T(2)* times in the human lung. These susceptibility gradients are dependent on the magnetic susceptibility of the respiratory gas and therefore should influence T(2)* relaxation. In this work, a technique for quantitative T(2)* mapping of the human lung during one breath hold is presented. Using this method, the lung T(2)* relaxation time was measured under normoxic (room air, 21% O(2)) and hyperoxic (100% O(2)) conditions to verify this assumption. The mean T(2)* difference between room air and 100% O(2) is about 10% and contains ventilation information, since only ventilated regions contribute to signal change due to different susceptibility gradients.
authors.affiliation: Department of Experimental Physics 5, University of Würzburg, Germany. edpracht@physik.uni-wuerzburg.de
authors.forename: Eberhard D
authors.initials: ED
authors.lastname: Pracht
authors.forename: Johannes F T
authors.initials: JF
authors.lastname: Arnold
authors.forename: Tungte
authors.initials: T
authors.lastname: Wang
authors.forename: Peter M
authors.initials: PM
authors.lastname: Jakob
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008168:Lung / Q000033:anatomy & histology* / Q000502:physiology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010100:Oxygen / Q000008:administration & dosage*; D012123:Pulmonary Ventilation
chemical_list: D010100:Oxygen