title: Evaluation of the therapeutic response to In-111-DTPA octreotide-based targeted therapy in liver metastatic neuroendocrine tumors according to CT/MRI/US findings.
abstract: Thirteen (13) patients with liver neuroendocrine carcinomas metastases, positive for somatostatin receptors, confirmed by scintigraphy were infused with 4070-7030 MBq per session of In-111-octreotide after selective hepatic catheterization, exploiting the catastrophic activity of Indium Auger and Internal Conversion electron emission on cell DNA. Evaluation of the treatment was assessed by ultrasonography (US) as well as by computed tomography and/or magnetic resonance imaging scans. US appears to be the imaging procedure of choice because the examination is sensitive for evaluating lesions' edema and cystic components, provides precise measurement of tumor size, and is inexpensive. Degeneration US signs were classified in stage I (an echolucent rim in the periphery of the lesion), stage IIa (lesion with large cystic spaces), stage IIb (tiny cystic spaces) and stage III (absorption of the cystic component or stable cystic remnants).
authors.affiliation: Nuclear Medicine Division, Department of Radiology, Aretaieion Hospital, University of Athens, 115028 Athens, Greece.
authors.forename: Georgios Spyridon
authors.initials: GS
authors.lastname: Limouris
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Dimitropoulos
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Kontogeorgakos
authors.forename: Georgios
authors.initials: G
authors.lastname: Papanikolos
authors.forename: Vassilios
authors.initials: V
authors.lastname: Koutoulidis
authors.forename: Achilleas
authors.initials: A
authors.lastname: Hatzioannou
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Mourikis
authors.forename: Maria
authors.initials: M
authors.lastname: Lyra
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Dimitriou
authors.forename: Anastasia
authors.initials: A
authors.lastname: Stravaka
authors.forename: Lambros
authors.initials: L
authors.lastname: Vlahos
mesh_terms: D000328:Adult; D000368:Aged; D004247:DNA / Q000378:metabolism; D005260:Female; D006801:Humans; D007204:Indium / Q000494:pharmacology; D007205:Indium Radioisotopes / Q000494:pharmacology*; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000473:pathology*; D009369:Neoplasms / Q000473:pathology; D018358:Neuroendocrine Tumors / Q000532:radiotherapy*; D015282:Octreotide / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004369:Pentetic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D011877:Radionuclide Imaging; D014057:Tomography, X-Ray Computed; D014465:Ultrasonics; D014463:Ultrasonography
chemical_list: C497824:111In-octreotide, DTPA(0)-; D007205:Indium Radioisotopes; D007204:Indium; D004369:Pentetic Acid; D004247:DNA; D015282:Octreotide