title: Corneal endothelial deposits associated with rifabutin use.
abstract: OBJECTIVE
  The aim of this study was to report on the possible development of corneal endothelial deposits resulting from the use of rifabutin.
  
  
  METHODS
  Case series consisting of 3 patients treated with rifabutin were retrospectively studied. Two of the patients were infected with human immunodeficiency virus. A corneal and external disease specialist performed a complete ophthalmologic exam and obtained medical histories of the patients.
  
  
  RESULTS
  All cases developed corneal endothelial deposits after previous use of rifabutin. The deposits were bilateral, yellow-white colored, stellate, and mainly peripheral.
  
  
  CONCLUSIONS
  In these 3 cases, the unique positive ocular finding was corneal endothelial deposits, which may be related to the use of rifabutin.
authors.affiliation: Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil. anamariacoutinho@hotmail.com
authors.forename: Anamaria Baptista
authors.initials: AB
authors.lastname: Coutinho
authors.forename: Devinder
authors.initials: D
authors.lastname: Cheema
authors.forename: Patricia R
authors.initials: PR
authors.lastname: Pereira
authors.forename: João P
authors.initials: JP
authors.lastname: Souza Filho
authors.forename: Miguel N
authors.initials: MN
authors.lastname: Burnier
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000517:prevention & control*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D003941:Diagnostic Techniques, Ophthalmological; D004334:Drug Administration Schedule; D004728:Endothelium, Corneal / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015270:Mycobacterium avium-intracellulare Infection / Q000517:prevention & control*; D012189:Retrospective Studies; D017828:Rifabutin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D014388:Tuberculosis, Lymph Node / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D017828:Rifabutin