Telomere and telomerase as targets for anti-cancer and regeneration therapies.
Telomerase is a ribonucleoprotein that directs the synthesis of telomeric sequence. It is detected in majority of malignant tumors, but not in most normal somatic cells. Because telomerase plays a critical role in cell immortality and tumor formation, it has been one of the targets for anti-cancer and regeneration drug development. In this review, we will discuss therapeutic approaches based mainly on small molecules that have been developed to inhibit telomerase activity, modulate telomerase expression, and telomerase directed gene therapy.
Hsu
Yi-hsin
YH
Institute of Biopharmaceutical Science, National Yang-Ming University, Taipei, Taiwan, China.
Lin
Jing-jer
JJ
D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D015316:Genetic Therapy; D006801:Humans; D009369:Neoplasms / Q000201:enzymology* / Q000628:therapy; D012333:RNA, Messenger / Q000378:metabolism; D019098:Telomerase / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D016615:Telomere / Q000473:pathology / Q000502:physiology*
D004268:DNA-Binding Proteins; D004791:Enzyme Inhibitors; D012333:RNA, Messenger; D019098:Telomerase