title: [Serum intercellular adhesion molecule ICAM-1 concentration in interferon alpha treated patients with chronic viral C hepatitis].
abstract: Intercellular adhesion molecule is a protein regulating the inflammatory cells movement. An increase of ICAM-1 expression on hepatocytes and in serum has been observed in patients with chronic viral hepatitis. Interferon alpha treatment should lead to inflammatory response diminution and serum ICAM-1 concentration decrease. The aim of the study was the estimation of interferon alpha treatment influence on serum ICAM-1 concentration in patients with chronic viral C hepatitis. A group of 19 interferon alpha treated patients with chronic viral C hepatitis has been observed. ALT activity, the presence of HCV antibody and HCV-RNAas well as histological examination has been estimated in every patient. Patients have got 144 doses of interferon alpha in a schedule 5 MU three times a week. After three months of treatment control estimations have been conducted for initial evoluation of treatment efficacy. Differences in ALT activity have been observed between I and III trials. ICAM-1 serum concentration has decreased significantly from 1322 to 369 pg/ml, and differences in ICAM-1 serum concentration have been observed in all trials. Estimation of serum ICAM-1 concentration is an indirect parameter of attenuation of inflammatory reaction after interferon alpha treatment.
authors.affiliation: Oddziału Chorób Zakaźnych w Bytomiu.
authors.forename: Iwona
authors.initials: I
authors.lastname: Warakomska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Wiczkowski
authors.forename: Lucjan
authors.initials: L
authors.lastname: Kepa
authors.forename: Wojciech
authors.initials: W
authors.lastname: Stolarz
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Wilczek
authors.forename: Dariusz
authors.initials: D
authors.lastname: Błedowski
authors.forename: Barbara
authors.initials: B
authors.lastname: Sobala-Szczygieł
authors.forename: Barbara
authors.initials: B
authors.lastname: Oczko-Grzesik
authors.forename: Andrzej P
authors.initials: AP
authors.lastname: Dziambor
authors.forename: Krystyna
authors.initials: K
authors.lastname: Mossor
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D006508:Hepatitis Antibodies / Q000276:immunology; D019698:Hepatitis C, Chronic / Q000097:blood* / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
chemical_list: D000998:Antiviral Agents; D006508:Hepatitis Antibodies; D016898:Interferon-alpha; D018799:Intercellular Adhesion Molecule-1; D000410:Alanine Transaminase