title: Imidazole and benzimidazole derivatives as chemotherapeutic agents.
abstract: Imidazole and benzimidazole systems are presented in a large number of common therapeutics agents. They were widely used in organic and medicinal chemistry, but recently the development of N-oxide derivatives got an improvement from the point of view of its chemical and biological activity. Though we will review recent developments in chemical and biological profiles (as antitumoral, antiparasitic, antiviral and antimicrobial agents) of these heterocycle systems and the corresponding N-oxides.
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias-Facultad de Química, Universidad de la República, Iguá 4225, CP 11400, Montevideo, Uruguay.
authors.forename: Mariana
authors.initials: M
authors.lastname: Boiani
authors.forename: Mercedes
authors.initials: M
authors.lastname: González
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D001562:Benzimidazoles / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D007093:Imidazoles / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D001562:Benzimidazoles; D007093:Imidazoles