title: Thyroid hormone and remyelination in adult central nervous system: a lesson from an inflammatory-demyelinating disease.
abstract: Re-myelination in the adult CNS has been demonstrated in different experimental models of demyelinating diseases. However, there is no clear evidence that re-myelination is effective in multiple sclerosis (MS), the most diffuse demyelinating disease. Moreover, chronic disabilities in MS are believed to be due to remyelination failure and consequent neuron damage and degeneration. Due to the presence of numerous oligodendrocyte precursors inside demyelination plaques, reasons for remyelination failure are unknown. In this paper, we reviewed data from embryonic development and in vitro studies supporting the primary role of thyroid hormone in oligodendrocyte maturation. We also reviewed personal data on the possibility of promoting myelination in chronic experimental allergic encephalomyelitis (EAE), a widely used experimental model of MS, by recruiting progenitors and channeling them into oligodendroglial lineage through the administration of thyroid hormone.
authors.affiliation: Department of Veterinary Morphophysiology and Animal Production, University of Bologna, Italy. lcalza@vet.unibo.it
authors.forename: Laura
authors.initials: L
authors.lastname: Calzà
authors.forename: Mercedes
authors.initials: M
authors.lastname: Fernandez
authors.forename: Alessandro
authors.initials: A
authors.lastname: Giuliani
authors.forename: Giulia
authors.initials: G
authors.lastname: D'Intino
authors.forename: Stefania
authors.initials: S
authors.lastname: Pirondi
authors.forename: Sandra
authors.initials: S
authors.lastname: Sivilia
authors.forename: Michela
authors.initials: M
authors.lastname: Paradisi
authors.forename: Nadia
authors.initials: N
authors.lastname: Desordi
authors.forename: Luciana
authors.initials: L
authors.lastname: Giardino
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000503:physiopathology*; D003711:Demyelinating Diseases / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D008959:Models, Neurological; D009186:Myelin Sheath / Q000378:metabolism; D009416:Nerve Regeneration / Q000502:physiology*; D013963:Thyroid Hormones / Q000378:metabolism* / Q000627:therapeutic use
chemical_list: D013963:Thyroid Hormones