Expression of p8 protein in breast carcinoma; an inverse relationship with apoptosis.
BACKGROUND
P8 is a transcription factor and its expression is elevated in response to apoptotic stimuli. However, p8 in human carcinoma tissue has not been investigated in depth. In this study, we investigated p8 expression in breast carcinoma.


METHODS
We immunohistochemically investigated p8 expression in 50 cases of breast carcinoma, including 7 non-invasive ductal carcinomas.


RESULTS
High expression of p8 was observed in 60% of cases, which was inversely related to tumor size and UICC stage. All non-invasive ductal carcinomas diffusely expressed p8. Furthermore, in tumors of 2 cm or larger, the p8 expression was inversely linked to the apoptotic index.


CONCLUSIONS
These results suggest that p8 plays a role in the early phase of breast carcinoma progression and especially in tumors of larger size, acting as an inhibitor of apoptosis of breast carcinoma cells.
Ito
Yasuhiro
Y
Department of Surgery, Kuma Hospital, Kobe City, Japan. ito01@kuma-h.or.jp
Yoshida
Hiroshi
H
Motoo
Yoshiharu
Y
Iovanna
Juan Lucio
JL
Nakamura
Yasushi
Y
Kakudo
Kennichi
K
Uruno
Takashi
T
Takamura
Yuuki
Y
Miya
Akihiro
A
Noguchi
Shinzaburo
S
Kuma
Kanji
K
Miyauchi
Akira
A
D017209:Apoptosis / Q000502:physiology*; D051792:Basic Helix-Loop-Helix Proteins; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology*; D044584:Carcinoma, Ductal / Q000378:metabolism / Q000473:pathology; D018275:Carcinoma, Lobular / Q000378:metabolism / Q000473:pathology; D004268:DNA-Binding Proteins / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis*
D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; C491643:NUPR1 protein, human