title: A new HLA-A allele, HLA-A*6824, identified in three unrelated individuals.
abstract: A novel allele, human leukocyte antigen (HLA)-A*6824, has been identified in three unrelated individuals of northwestern European origin in a period of less than 4 months, implying that this allele may be quite common in this population. HLA-A*6824 differs from A*680102 by a single nucleotide change at position 275 in exon 2, which results in a conservative amino acid substitution from lysine to arginine in the peptide-binding groove at codon 68.
authors.affiliation: H&I Laboratory, National Blood Service, Colindale, London, UK.
authors.forename: S
authors.initials: S
authors.lastname: Davey
authors.forename: V
authors.initials: V
authors.lastname: Carter
authors.forename: R
authors.initials: R
authors.lastname: Goodman
authors.forename: S
authors.initials: S
authors.lastname: Day
authors.forename: C
authors.initials: C
authors.lastname: Brown
authors.forename: J
authors.initials: J
authors.lastname: Morris
authors.forename: T
authors.initials: T
authors.lastname: Key
authors.forename: N
authors.initials: N
authors.lastname: Bendukidze
authors.forename: P P J
authors.initials: PP
authors.lastname: Dunn
mesh_terms: D000328:Adult; D000483:Alleles; D019943:Amino Acid Substitution; D004739:England; D005091:Exons / Q000235:genetics; D005260:Female; D005805:Genes, MHC Class I; D015234:HLA-A Antigens / Q000737:chemistry / Q000235:genetics* / Q000302:isolation & purification; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics
chemical_list: D015234:HLA-A Antigens; C503733:HLA-A*68:24 antigen