DTPA-bisamide-based MR sensor agents for peroxidase imaging.
[reaction: see text] The synthesis and some properties of two novel DTPA-bisamides are reported. These derivatives were designed as enzyme-activated contrast agents (CA) for magnetic resonance imaging. Both derivatives bear tyramido or 5-hydroxytryptamido groups that could be oligomerized in situ in the presence of peroxidase/H(2)O(2) pair resulting in a net increase in longitudinal (R1) relaxivity.
Querol
Manuel
M
Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA.
Chen
John W
JW
Weissleder
Ralph
R
Bogdanov
Alexei
A
D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry; D019786:Gadolinium DTPA / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D004369:Pentetic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D010544:Peroxidases / Q000378:metabolism*
D003287:Contrast Media; D004369:Pentetic Acid; D010544:Peroxidases; D019786:Gadolinium DTPA