Lyprinol (stabilised lipid extract of New Zealand green-lipped mussel): a potential preventative treatment modality for inflammatory bowel disease.
BACKGROUND
Lyprinol (Pharmalink International), the stabilised lipid extract of the New Zealand green-lipped mussel, is currently used to relieve symptoms of arthritis. We investigated the effect of pretreatment with Lyprinol (LYP) on experimentally induced inflammatory bowel disease (IBD) in mice.


METHODS
Male C57BL/6 mice (aged 6 weeks) were gavaged daily for 13 days with (150 microl) olive oil (OO; n = 7), fish oil (FO; n = 8), or LYP (n = 8). Mice consumed 2% dextran sulfate sodium (DSS) for 6 days, starting on day 7. Body weight and disease activity index (DAI) scores were recorded daily. Colonic damage was determined by histopathology. Colonic inflammation was quantified by myeloperoxidase (MPO) activity.


RESULTS
LYP treatment significantly (P < 0.05) reduced body weight loss, DAI scores, crypt area losses, and cecum and colon weights, compared with FO treatment. MPO activity was not significantly affected by any treatment.


CONCLUSIONS
These findings provide preliminary evidence that Lyprinol may be potentially useful in ameliorating symptoms of IBD. The benefit, however, is unlikely to be due to the omega-3 fatty acid content. Dose-response evaluation of Lyprinol in experimental IBD is warranted.
Tenikoff
Danik
D
Child Health Research Institute, Women's and Children's Hospital, North Adelaide, South Australia, Australia.
Murphy
Karen J
KJ
Le
Maria
M
Howe
Peter R
PR
Howarth
Gordon S
GS
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003093:Colitis, Ulcerative / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D003106:Colon / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D016264:Dextran Sulfate / Q000633:toxicity; D004195:Disease Models, Animal; D018450:Disease Progression; D004359:Drug Therapy, Combination; D005395:Fish Oils / Q000008:administration & dosage / Q000627:therapeutic use; D005500:Follow-Up Studies; D008055:Lipids / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D000069463:Olive Oil; D009929:Organ Size / Q000187:drug effects; D009195:Peroxidase / Q000378:metabolism; D010938:Plant Oils / Q000008:administration & dosage / Q000627:therapeutic use; D010952:Plasma Substitutes / Q000633:toxicity; D016896:Treatment Outcome
D005395:Fish Oils; D008055:Lipids; D000069463:Olive Oil; D010938:Plant Oils; D010952:Plasma Substitutes; C418997:lyprinol; D016264:Dextran Sulfate; D009195:Peroxidase