Evaluation of the role of the endocytic receptor L-SIGN for cytoadhesion of Plasmodium falciparum-infected erythrocytes.
Hepatic cell populations play an important role during the malaria life cycle. L-SIGN, a homologue of DC-SIGN, mediating leukocyte and pathogen binding, is selectively expressed on liver endothelial cells. Here, we present evidence that L-SIGN acts as an endocytic cell surface receptor. However, P. falciparum-infected erythrocytes did not cytoadhere to L-SIGN. Thus, L-SIGN contributes to elimination of mannosylated ligands but does not participate in hepatic clearance of P. falciparum-infected erythrocytes.
Viebig
Nicola K
NK
Hygiene Institut, Abteilung Parasitologie, Universität Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany.
Andrews
Katherine T
KT
Kooyk
Yvette van
Yv
Lanzer
Michael
M
Knolle
Percy A
PA
D000818:Animals; D016466:CHO Cells / Q000378:metabolism / Q000469:parasitology*; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D006224:Cricetinae; D003412:Cricetulus; D004912:Erythrocytes / Q000378:metabolism / Q000469:parasitology*; D006801:Humans; D037181:Lectins, C-Type / Q000378:metabolism*; D016778:Malaria, Falciparum / Q000378:metabolism / Q000469:parasitology*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010963:Plasmodium falciparum / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000378:metabolism*
C433029:CLEC4M protein, human; D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D009419:Nerve Tissue Proteins; D011956:Receptors, Cell Surface