Transcriptional regulation of endothelin.
Three isoforms of endothelin (ET) exist, ET-l, ET-2,and ET-3.Nucleotide sequences for the three human ET genes are highly conserved. ET-l exactly matches the sequence ofET originally isolated from the condi- tioned medium of cultured bovine aortic endothelial cells (BAECs)."All three forms have been found in vascular, neural, adrenal, and kidney tissue, but are expressed in different proportions. Endothelial cells ex- clusively produce ETAll three isoforms have different vasoconstrictive potencies but are otherwise quali- tatively similar. ET-2 is the most potent vasoconstrictor, followed by ET-l and ET.
Koo
J T
JT
Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.
Sawyer
M D
MD
Powell
R J
RJ
Sumpio
B E
BE