title: Oral administration of royal jelly facilitates mRNA expression of glial cell line-derived neurotrophic factor and neurofilament H in the hippocampus of the adult mouse brain.
abstract: Royal jelly (RJ) is known to have a variety of biological activities toward various types of cells and tissues of animal models, but nothing is known about its effect on brain functions. Hence, we examined the effect of oral administration of RJ on the mRNA expression of various neurotrophic factors, their receptors, and neural cell markers in the mouse brain. Our results revealed that RJ selectively facilitates the mRNA expression of glial cell line-derived neurotrophic factor (GDNF), a potent neurotrophic factor acting in the brain, and neurofilament H, a specific marker predominantly found in neuronal axons, in the adult mouse hippocampus. These observations suggest that RJ shows neurotrophic effects on the mature brain via stimulation of GDNF production, and that enhanced expression of neurofilament H mRNA is involved in events subsequently caused by GDNF. RJ may play neurotrophic and/or neuroprotective roles in the adult brain through GDNF.
authors.affiliation: Laboratory of Molecular Biology, Gifu Pharmaceutical University, Gifu 502-8585, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kanda
authors.forename: Kumiko
authors.initials: K
authors.lastname: Ikeno
authors.forename: Yoshirou
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nakamura
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Fukumitsu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nomoto
authors.forename: Shoei
authors.initials: S
authors.lastname: Furukawa
mesh_terms: D000284:Administration, Oral; D000375:Aging / Q000502:physiology; D000818:Animals; D018076:DNA, Complementary / Q000235:genetics; D005227:Fatty Acids / Q000008:administration & dosage* / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects*; D051100:Glial Cell Line-Derived Neurotrophic Factor; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D051379:Mice; D009414:Nerve Growth Factors / Q000235:genetics*; D016900:Neurofilament Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D000099219:Royal Jelly
chemical_list: D018076:DNA, Complementary; D005227:Fatty Acids; D051100:Glial Cell Line-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D016900:Neurofilament Proteins; D012333:RNA, Messenger; D000099219:Royal Jelly; C495040:Gdnf protein, mouse; C051774:neurofilament protein H