title: Hysterectomy with or without unilateral oophorectomy and risk of ovarian cancer.
abstract: OBJECTIVE
  To analyze the role of hysterectomy, performed on benign indications, on the risk of developing ovarian cancer.
  
  
  METHODS
  Multicenter case-control study conducted in four Italian areas. Cases were 1031 women with epithelial ovarian cancer. Controls were 2411 women admitted to the same network of hospitals for a wide spectrum of acute non-neoplastic conditions, unrelated to known risk factors for ovarian cancer.
  
  
  RESULTS
  Compared to women with intact uterus and ovaries, the multivariate odds ratios (OR) was 0.6 (95% confidence interval 0.4-0.9) for women who reported hysterectomy. The OR was 0.5 > or =15 years after surgery. The OR was similar for women who had had pelvic surgery before age 45 and for those who had surgery later. No appreciable heterogeneity emerged across strata of parity and family history of ovarian/breast cancer.
  
  
  CONCLUSIONS
  Women who had undergone hysterectomy had a long-term reduced risk of epithelial ovarian cancer.
authors.affiliation: Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Chiaffarino
authors.forename: Fabio
authors.initials: F
authors.lastname: Parazzini
authors.forename: Adriano
authors.initials: A
authors.lastname: Decarli
authors.forename: Silvia
authors.initials: S
authors.lastname: Franceschi
authors.forename: Renato
authors.initials: R
authors.lastname: Talamini
authors.forename: Maurizio
authors.initials: M
authors.lastname: Montella
authors.forename: Carlo
authors.initials: C
authors.lastname: La Vecchia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007558:Italy / Q000453:epidemiology; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000517:prevention & control; D010052:Ovariectomy; D012307:Risk Factors