Rifaximin in the treatment of infectious diarrhea.
Rifaximin matches the criteria for an ideal agent for the treatment of infectious diarrhea. It has excellent activity against a broad range of enteropathogens. It is nonabsorbable, which may help explain its excellent side effect profile and lack of emergence of resistance because of high stool levels that are not likely to reach subinhibitory levels before the target Gram-negative bacilli are killed. It has shown excellent efficacy in numerous clinical trials of bacterial diarrhea. Because of the lack of systemic absorption and minimal adverse reactions, rifaximin should be useful in treating hosts such as pregnant women in whom the currently favored fluoroquinolones are contraindicated. Uses limited to enteric indications and its inherently low propensity to induce sustainable resistance among Gram-negative flora favor the sustained usefulness of rifaximin in the treatment of enteric infectious syndromes.
Ericsson
Charles D
CD
Department of Internal Medicine and Division of Infectious Diseases, University of Texas Houston Medical School, Houston, TX 77030, USA. Charles.D.Ericsson@uth.tmc.edu
DuPont
Herbert L
HL
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002648:Child; D024881:Drug Resistance, Bacterial; D004403:Dysentery / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006801:Humans; D007408:Intestinal Absorption; D008826:Microbial Sensitivity Tests; D011247:Pregnancy; D016032:Randomized Controlled Trials as Topic; D012294:Rifamycins / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000078262:Rifaximin
D000900:Anti-Bacterial Agents; D012294:Rifamycins; D000078262:Rifaximin