title: Clinical experience in managing Fusarium solani keratitis.
abstract: Fusarium solani keratitis is a rare ocular infectious disease. The clinical characteristics and treatment methods of 18 patients with culture proven F. solani keratitis between July 1997 and December 2003 and with a follow-up period of more than 4 months were analysed retrospectively. The patients were divided into two groups based on the severity of keratitis. Group A (n = 13) displayed non-severe keratitis and were treated with debridement, lamellar keratectomy and antifungal medication. Group B (n = 5) displayed severe keratomycosis and were treated with lamellar keratectomy combined with amniotic membrane transplantation (AMT) and antifungal medication. In group A, wound healing did not interfere with the integrity of the anterior chamber. The mean re-epithelialisation time was 12.67 days (range: 5-21 days). All patients were free of major immediate postoperative complications. In group B, AMT preserved the anterior chamber integrity in two cases, but failed to do so in the other three cases. Therapeutic patch grafts were required in these three cases. Non-severe F. solani keratitis is best treated with superficial keratectomy. Timely AMT combined with lamellar keratectomy appears to be an adjuvant therapy for severe keratomycosis and avoiding emergent therapeutic penetrating keratoplasty. However, AMT was effective in cases involving non-suppurative Fusarium keratitis.
authors.affiliation: Department of Ophthalmology, Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan. hclinn@adm.cgmh.org.tw
authors.forename: H-C
authors.initials: HC
authors.lastname: Lin
authors.forename: P-H
authors.initials: PH
authors.lastname: Chu
authors.forename: Y-H
authors.initials: YH
authors.lastname: Kuo
authors.forename: S-C
authors.initials: SC
authors.lastname: Shen
mesh_terms: D000328:Adult; D000368:Aged; D000650:Amnion / Q000637:transplantation; D000935:Antifungal Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003315:Cornea / Q000601:surgery; D015821:Eye Infections, Fungal / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D005670:Fusarium; D006801:Humans; D007634:Keratitis / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D012189:Retrospective Studies; D014945:Wound Healing
chemical_list: D000935:Antifungal Agents