Thermally gated liposomes.
The combined use of a pore-forming amphiphile, 1 (derived from lysine, cholic acid, and spermine), and thermally sensitive liposomes (made from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, DPPC) to create "thermally gated liposomes" (TGLs) has been demonstrated. Thus, at temperatures that lie above the gel to liquid-crystalline phase transition temperature of DPPC (i.e., 41 degrees C), 1 creates pores within DPPC membranes through which entrapped aqueous solutes, such as carboxyfluorescein, can readily pass. Below this temperature, efflux rates are greatly reduced. The potential of TGLs as devices for the targeted delivery of therapeutic agents is briefly discussed.
Chen
Wen-Hua
WH
Department of Chemistry, Lehigh University, Bethlehem, PA 18015, USA.
Regen
Steven L
SL
D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry*; D016503:Drug Delivery Systems; D005452:Fluoresceins / Q000737:chemistry*; D007700:Kinetics; D008051:Lipid Bilayers / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry*; D010713:Phosphatidylcholines / Q000737:chemistry; D013096:Spermine / Q000031:analogs & derivatives / Q000737:chemistry; D013696:Temperature
D005452:Fluoresceins; D008051:Lipid Bilayers; D008081:Liposomes; D010713:Phosphatidylcholines; D015060:1,2-Dipalmitoylphosphatidylcholine; D013096:Spermine; C024098:6-carboxyfluorescein; C028694:1-palmitoyl-2-oleoylphosphatidylcholine