Orthotopic liver transplantation for biliary atresia.
Biliary atresia (BA) represents the most frequent indication for liver transplantation (OLTX) in the pediatric population. The aim of this paper was to present a series collected over the last 7 years from October 1997 through July 2004, including 260 pediatric OLTX in 231 patients. BA was the indication in 137 patients. There were 69 boys and 68 girls of mean weight 10.68 kg and median age 0.9 years. As a primary transplant, 99 patients received a LLS graft; 27 a whole graft; four a I+IV-VIII segment, and two a I-IV segment. Mean follow up was 1047 days (range, 1-2496 day). Infections were diagnosed in 45 patients, vascular complications in 27 patients. Surgical complications that required reintervention occurred in 25 patients. In 41 cases biliary complications occurred, 11 requiring reintervention. 16 patients were retransplanted. In two cases another re-OLTx was performed. Currently 126 patients are alive, showing an actuarial 1 year survival of 92% and 5 year 91%, with actuarial graft survivals of 85% at 1 year and 82% at 3 and 5 years. Our results confirm the effectiveness of OLTx for the treatment of children with BA and a failed Kasai procedure. Split liver grafts represent an excellent organ supply for these patients, achieving optimal results with no mortality on the waiting list.
Colledan
M
M
Ospedali Riuniti di Bergamo, Italy.
Torri
E
E
Bertani
A
A
Corno
V
V
Guizzetti
M
M
Lucianetti
A
A
Maldini
G
G
Pinelli
D
D
Zambelli
M
M
Giovanelli
M
M
Carrara
B
B
Riva
S
S
Alberti
D
D
Passoni
M
M
Spada
M
M
Gridelli
B
B
Torre
G
G
D000017:ABO Blood-Group System; D000293:Adolescent; D001656:Biliary Atresia / Q000601:surgery*; D001787:Blood Group Incompatibility; D002648:Child; D002675:Child, Preschool; D005260:Female; D006085:Graft Survival; D006801:Humans; D007223:Infant; D007431:Intraoperative Complications / Q000453:epidemiology; D016031:Liver Transplantation / Q000276:immunology / Q000379:methods / Q000401:mortality; D008297:Male; D011183:Postoperative Complications / Q000453:epidemiology; D012086:Reoperation / Q000706:statistics & numerical data; D012189:Retrospective Studies; D016019:Survival Analysis
D000017:ABO Blood-Group System