Transcriptome analysis of the progressive adaptation of Lactococcus lactis to carbon starvation.
Adaptation of Lactococcus lactis towards progressive carbon starvation is mediated by three different types of transcriptomic responses: (i) global responses, i.e., general decreases of functions linked to bacterial growth and lack of induction of the general stress response; (ii) specific responses functionally related to glucose exhaustion, i.e., underexpression of central metabolism genes, induction of alternative sugar transport and metabolism, and induction of the arginine deiminase pathway; and (iii) other responses never described previously during carbon starvation.
Redon
Emma
E
Laboratoire Biotechnologie-Bioprocédés, UMR 5504 INSA/CNRS and UMR792 INSA/INRA, Institut National des Sciences Appliquées, 135 Avenue de Rangueil, 31077 Toulouse cedex 4, France.
Loubiere
Pascal
P
Cocaign-Bousquet
Muriel
M
D000222:Adaptation, Physiological; D002244:Carbon / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology*; D005947:Glucose / Q000378:metabolism; D013294:Lactococcus lactis / Q000235:genetics* / Q000378:metabolism*; D012329:RNA, Bacterial / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D014158:Transcription, Genetic / Q000502:physiology*
D012329:RNA, Bacterial; D012333:RNA, Messenger; D002244:Carbon; D005947:Glucose