title: Cardiac output by PulseCO is not interchangeable with thermodilution in patients undergoing OPCAB.
abstract: OBJECTIVE
  To investigate the reliability of cardiac output assessed by arterial pressure waveform (PulseCO) in comparison with bolus thermodilution measurements in patients undergoing off-pump coronary artery bypass grafting (OPCAB).
  
  
  METHODS
  23 patients who underwent OPCAB were enrolled in this study. After premedication with oral diazepam 10 mg, anesthesia was induced with midazolam, fentanyl and vecuronium. After induction, radial artery and pulmonary artery catheters were inserted. Cardiac output was measured simultaneously by the PulseCO and the bolus thermodilution method using the Vigilance monitor: 1) after sternotomy, 2) after opening the mediastinum, and 3) at the end of surgery. The PulseCO was calibrated initially with cardiac output determined by the thermodilution method after induction of anesthesia.
  
  
  RESULTS
  The correlation coefficients between the two techniques at the three measurement periods were: 1) R2 = 0.49, 2) R2 = 0.52, 3) R2 = 0.55. The limits of agreement (bias +/- 2 SD of bias) were: 1) 0.71 +/- 2.66, 2) 0.30 +/- 1.97, 3) 0.76 +/- 3.85 L.min(-1).
  
  
  CONCLUSIONS
  Cardiac output by PulseCO is not interchangeable with cardiac output measured by thermodilution in patients undergoing OPCAB.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Kochi Medical School, Kohasu, Oko-cho, Nankoku-shi, Kochi, 783-8505, Japan. koichiya@kochi-ms.ac.jp
authors.forename: Koichi
authors.initials: K
authors.lastname: Yamashita
authors.forename: Tomoki
authors.initials: T
authors.lastname: Nishiyama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Abe
authors.forename: Masanobu
authors.initials: M
authors.lastname: Manabe
mesh_terms: D000368:Aged; D001794:Blood Pressure; D002302:Cardiac Output; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013815:Thermodilution