title: Predictive factors for intracerebral hemorrhage in patients with cavernous angiomas.
abstract: OBJECTIVE
  Prediction of intracerebral hemorrhage (ICH) in patients with cavernous angiomas is not totally elucidated. The aims of our study were to determine the rate of cerebral hemorrhage, its associated factors, and the clinical outcome in patients with cavernous angiomas in a Hispanic population.
  
  
  METHODS
  We studied 133 patients with cavernous angiomas. The patients were classified into two groups depending on whether they presented an ICH. A comparative analysis of demographics and clinical data, neuroimaging characteristics, and prognosis was carried out in patients with and without hemorrhage. The hemorrhage rate (expressed as the percentage per patient per year) was also estimated.
  
  
  RESULTS
  Seventy-eight patients (59%) had hemorrhage. Non-lobar location of angiomas was associated with hemorrhage [OR 4.82 (CI 95% 2.17-10.73; p=<0.001)]. In contrast, factors associated with a decreased risk of hemorrhage were a family history of epilepsy [OR 0.30 (CI 95% 0.10-0.79; p=0.016)] and lobar location of the angiomas [OR 0.21 (CI 95% 0.09-0.46; p=<0.001)]. The hemorrhagic rate of 1.71% per patient per year was influenced by the location. It was only 1.22% per patient per year in lobar angiomas and 2.33, 2.39, and 2.82% per patient per year for brainstem, cerebellum, and deep hemispheric angiomas, respectively.
  
  
  CONCLUSIONS
  The non-lobar location of cavernous angiomas gives a higher risk of hemorrhage in our Mexican mestizo population, without the hemorrhage being related to either age or sex.
authors.affiliation: Stroke Clinic, Manuel Velasco Suarez National Institute of Neurology and Neurosurgery, Insurgentes Sur 3877, Colonia La Fama, Delegación Tlalpan, Mexico, DF, CP 14269.
authors.forename: Carlos
authors.initials: C
authors.lastname: Cantu
authors.forename: Luis
authors.initials: L
authors.lastname: Murillo-Bonilla
authors.forename: Antonio
authors.initials: A
authors.lastname: Arauz
authors.forename: Jesús
authors.initials: J
authors.lastname: Higuera
authors.forename: Joel
authors.initials: J
authors.lastname: Padilla
authors.forename: Fernando
authors.initials: F
authors.lastname: Barinagarrementeria
mesh_terms: D000328:Adult; D002543:Cerebral Hemorrhage / Q000453:epidemiology* / Q000209:etiology*; D003710:Demography; D005260:Female; D005500:Follow-Up Studies; D023261:Glasgow Outcome Scale / Q000706:statistics & numerical data; D006392:Hemangioma, Cavernous / Q000145:classification / Q000150:complications*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012306:Risk