title: The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway.
abstract: The vagus nerve forms a neuro-anatomical link between the gastrointestinal tract and the brain. A number of gastrointestinal hormones, including cholecystokinin and ghrelin, require an intact vagal-brainstem-hypothalamic pathway to affect CNS feeding circuits. We have shown that the effects of peripheral administration of both peptide YY(3-36) (PYY(3-36)) and glucagon-like peptide-1 (GLP-1) on food intake and activation of hypothalamic arcuate feeding neurones are abolished following either bilateral sub-diaphragmatic total truncal vagotomy or brainstem-hypothalamic pathway transectioning in rodents. These findings suggest that the vagal-brainstem-hypothalamic pathway may also play a role in the effects of circulating PYY(3-36) and GLP-1 on food intake.
authors.affiliation: Imperial College London, 6th Floor Commonwealth Building, Hammersmith Campus, Du Cane Road, London W12 ONN, UK.
authors.forename: Caroline R
authors.initials: CR
authors.lastname: Abbott
authors.forename: Mariana
authors.initials: M
authors.lastname: Monteiro
authors.forename: Caroline J
authors.initials: CJ
authors.lastname: Small
authors.forename: Arshia
authors.initials: A
authors.lastname: Sajedi
authors.forename: Kirsty L
authors.initials: KL
authors.lastname: Smith
authors.forename: James R C
authors.initials: JR
authors.lastname: Parkinson
authors.forename: Mohammad A
authors.initials: MA
authors.lastname: Ghatei
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Bloom
mesh_terms: D000818:Animals; D001933:Brain Stem / Q000187:drug effects* / Q000502:physiology; D003714:Denervation / Q000379:methods; D004435:Eating / Q000187:drug effects*; D004525:Efferent Pathways / Q000187:drug effects / Q000502:physiology; D007031:Hypothalamus / Q000187:drug effects* / Q000502:physiology; D007266:Inhibition, Psychological; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D009281:Naphthalenes; D010082:Oxepins; D010446:Peptide Fragments; D019894:Peptide YY / Q000008:administration & dosage*; D010455:Peptides / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D014628:Vagotomy / Q000379:methods; D014630:Vagus Nerve / Q000187:drug effects* / Q000502:physiology
chemical_list: C461941:1-phenyl-1,4-epoxy-1H,4H-naphtho(1,8-de)(1,2)dioxepin; D036341:Intercellular Signaling Peptides and Proteins; D009281:Naphthalenes; D010082:Oxepins; D010446:Peptide Fragments; D010455:Peptides; D019894:Peptide YY; C061785:peptide YY (3-36); C037686:glucagon releasing peptide