title: Circadian rhythm of acute phase proteins under the influence of bright/dim light during the daytime.
abstract: We investigated the influence of two different light intensities, dim (100 lx) and bright (5000 lx), during the daytime on the circadian rhythms of selected acute phase proteins of C-reactive protein (CRP), alpha1-acid glycoprotein (AGP), alpha1-antichymotrypsin (ACT), transfferin (TF), alpha2-macroglobulin (alpha2-m), haptoglobin (HP), and ceruloplasmin (CP). Serum samples were collected from 7 healthy volunteers at 4 h intervals during two separate single 24 h spans during which they were exposed to the respective light intensity conditions. A circadian rhythm was detected only in ACT concentration in the bright light condition. The concentration of ACT, a positive acute phase protein (APP), increased (significantly significant differences in the ACT concentration were detected at 14:00 and 22:00 h) and AGP showed a tendency to be higher under the daytime bright compared to dim light conditions. There were no significant differences between the time point means under daytime dim and bright light conditions for alpha2-M, AGP, Tf, Cp, or Hp. The findings suggest that some, but not all, APP may be influenced by the environmental light intensity.
authors.affiliation: Department of Environmental Health, Nara Women's University, Nara, Japan. dkanikowska@hotmail.com
authors.forename: Dominika
authors.initials: D
authors.lastname: Kanikowska
authors.forename: Ki-Ja
authors.initials: KJ
authors.lastname: Hyun
authors.forename: Hiromi
authors.initials: H
authors.lastname: Tokura
authors.forename: Takashi
authors.initials: T
authors.lastname: Azama
authors.forename: Shinya
authors.initials: S
authors.lastname: Nishimura
mesh_terms: D000209:Acute-Phase Proteins / Q000096:biosynthesis / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D002097:C-Reactive Protein / Q000096:biosynthesis; D002570:Ceruloplasmin / Q000096:biosynthesis; D002940:Circadian Rhythm; D005260:Female; D006242:Haptoglobins / Q000096:biosynthesis; D006801:Humans; D008027:Light; D008597:Menstrual Cycle; D009961:Orosomucoid / Q000096:biosynthesis; D017440:Photoperiod; D010865:Pilot Projects; D013997:Time Factors; D014168:Transferrin / Q000096:biosynthesis; D000514:alpha 1-Antichymotrypsin / Q000096:biosynthesis / Q000097:blood; D000511:alpha-Macroglobulins / Q000096:biosynthesis
chemical_list: D000209:Acute-Phase Proteins; D006242:Haptoglobins; D009961:Orosomucoid; D014168:Transferrin; D000514:alpha 1-Antichymotrypsin; D000511:alpha-Macroglobulins; D002097:C-Reactive Protein; D002570:Ceruloplasmin