Peptide-oligonucleotide conjugates for the delivery of antisense and siRNA.
Conjugation of oligonucleotides to certain types of peptides provides an interesting approach for enhancing delivery of antisense and siRNA to cells and tissues. This article will provide a perspective on issues in oligonucleotide delivery, and will examine recent literature on the preparation and use of several types of peptide-oligonucleotide conjugates.
Juliano
Rudolph L
RL
University of North Carolina, Department of Pharmacology, School of Medicine, Chapel Hill, NC 27599, USA. arjay@med.unc.edu
D000818:Animals; D016503:Drug Delivery Systems; D006801:Humans; D016376:Oligonucleotides, Antisense / Q000008:administration & dosage*; D010455:Peptides; D034741:RNA, Small Interfering / Q000008:administration & dosage*
D016376:Oligonucleotides, Antisense; D010455:Peptides; D034741:RNA, Small Interfering