title: Acute diuretic effect of aqueous extract of Retama raetam in normal rats.
abstract: The purpose of this study was to examine the acute diuretic effect of the water extract of the aerial parts of Retama raetam (RR) at a dose of 5 mg/kg/h in normal rats. The aqueous extract was administered intravenously and the diuresis was followed within 4 h after starting the treatment. Intravenous administration of the aqueous RR extract produced a significant increment on diuresis from the second hour (p<0.01) to the fourth hour (p<0.001). Furosemide at a dose of 0.1 mg/kg/h had a similar effect when compared to RR administration. Parallel, the noticed increase of diuresis was associated with an elevation of glomerular filtration rate (p<0.05) and a significant decrease of urinary osmolarity (p<0.001). However, RR extract did not affect plasma urea levels, urine pH, plasma osmolarity and hematocrite. It is then concluded that the water extract of the aerial parts of RR exhibited a significant diuretic effect in normal rat.
authors.affiliation: UFR PNPE, BP 21, Errachidia, Morocco.
authors.forename: M
authors.initials: M
authors.lastname: Maghrani
authors.forename: N-A
authors.initials: NA
authors.lastname: Zeggwagh
authors.forename: M
authors.initials: M
authors.lastname: Haloui
authors.forename: M
authors.initials: M
authors.lastname: Eddouks
mesh_terms: D000818:Animals; D004232:Diuretics / Q000494:pharmacology*; D007887:Fabaceae / Q000737:chemistry*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006400:Hematocrit; D006863:Hydrogen-Ion Concentration; D009018:Morocco; D009994:Osmolar Concentration; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014508:Urea / Q000097:blood; D014563:Urodynamics / Q000187:drug effects
chemical_list: D004232:Diuretics; D010936:Plant Extracts; D014508:Urea