Surfactant protein C: basics to bedside.
Development of clinically active synthetic surfactants has turned out to be more complicated than initially anticipated. Surfactant protein analogues must have the right conformation without forming oligomers. Furthermore, the lipid composition, as well as a high lipid concentration in the suspension seem to be important. For successful treatment of many respiratory diseases, it is desirable that the synthetic surfactant may stabilize the alveoli at end-expiration and may resist inactivation by components leaking into the alveoli.
Curstedt
Tore
T
Department of Clinical Chemistry, Karolinska University Hospital, Stockholm, Sweden.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D037721:Pulmonary Surfactant-Associated Protein C / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D011994:Recombinant Proteins / Q000494:pharmacology; D013678:Technology, Pharmaceutical
D037721:Pulmonary Surfactant-Associated Protein C; D011994:Recombinant Proteins