title: Influence of the R22H variant of macrophage inflammatory protein 1beta/Lag-1 in HIV-1 survival.
abstract: The chemokine macrophage inflammatory protein 1beta/CCL4, ligand of the major HIV co-receptor CCR5, is encoded by two genes, Act-2 and Lag-1. Our work focused on R22H, a variant of Lag-1 located near the N-loop, in the 310 turn, a domain essential for interacting with CCR5. We observed that HIV-1-infected patients from the SEROCO cohort, bearing the R22H variant either at the homozygous or heterozygous state, exhibit a worse global survival compared with wild-type homozygous individuals.
authors.affiliation: INSERM U543, CHU Pitié-Salpétrière, Paris, France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Capoulade-Métay
authors.forename: Laurence
authors.initials: L
authors.lastname: Meyer
authors.forename: Ton
authors.initials: T
authors.lastname: Tran
authors.forename: Anne
authors.initials: A
authors.lastname: Persoz
authors.forename: Anne
authors.initials: A
authors.lastname: Bourdais
authors.forename: Yasmine
authors.initials: Y
authors.lastname: Dudoit
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Delfraissy
authors.forename: Patrice
authors.initials: P
authors.lastname: Debré
authors.forename: Ioannis
authors.initials: I
authors.lastname: Theodorou
mesh_terms: D054407:Chemokine CCL4; D015331:Cohort Studies; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology / Q000401:mortality; D015497:HIV-1; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D019402:Macrophage Inflammatory Proteins / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D019713:Receptors, CCR5 / Q000378:metabolism; D016019:Survival Analysis
chemical_list: D054407:Chemokine CCL4; D019402:Macrophage Inflammatory Proteins; D019713:Receptors, CCR5