title: Effect of orthotopic small bowel transplantation on mineral metabolism in an experimental model.
abstract: BACKGROUND
  Numerous experimental models have been described for investigation of short bowel syndrome. The aim of this study was to examine the effect of orthotopic small bowel transplantation (OSBT) on universal metabolism in an inbred rat model, with particular emphasis on mineral metabolism.
  
  
  METHODS
  Jejunoileal resection and syngeneic OSBT was performed in 12-week-old male Lewis rats. Metabolic studies were performed over the following 16 weeks. Bones were analysed by physicochemical methods, dual X-ray absorptiometry, biomechanical procedures and histomorphometry. Biochemical markers of bone turnover were also measured.
  
  
  RESULTS
  Jejunoileal resection induced severe short bowel syndrome with profoundly reduced food efficiency, bone size, fracturing energy and bone mineral content, but no cancellous bone osteopenia. After OSBT rats showed normal growth; bones were of normal size, and bone mineral content and fracturing energy were similar to those in sham-operated controls. However, tibial, but not vertebral, cancellous bone osteopenia was found after transplantation.
  
  
  CONCLUSIONS
  OSBT with portal venous drainage achieves almost optimal mineral and bone metabolism. In the absence of immunosuppressive therapy, OSBT does not appear to have major untoward side-effects on bone in rats.
authors.affiliation: Department of Surgery, Military Hospital Ulm, Germany. sdkastl@aol.com
authors.forename: S
authors.initials: S
authors.lastname: Kastl
authors.forename: V
authors.initials: V
authors.lastname: Müller
authors.forename: U
authors.initials: U
authors.lastname: Kotschenreuther
authors.forename: M
authors.initials: M
authors.lastname: Radespiel-Troeger
authors.forename: W
authors.initials: W
authors.lastname: Hohenberger
authors.forename: R G
authors.initials: RG
authors.lastname: Erben
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D015519:Bone Density; D005500:Follow-Up Studies; D007421:Intestine, Small / Q000378:metabolism / Q000637:transplantation*; D008297:Male; D008903:Minerals / Q000378:metabolism*; D051381:Rats; D011917:Rats, Inbred Lew; D015996:Survival Rate
chemical_list: D008903:Minerals