title: A randomised controlled trial of biopsy forceps and cannula aspiration for transcervical chorionic villus sampling.
abstract: OBJECTIVE
  This trial compared two instruments for transcervical chorionic villus sampling (CVS).
  
  
  METHODS
  Randomised controlled trial.
  
  
  METHODS
  Regional university prenatal diagnosis and treatment centre.
  
  
  METHODS
  Two hundred women were randomised at 10(+0)-12(+6) weeks of gestation to transcervical CVS using cannula aspiration (CA) or biopsy forceps (BF).
  
  
  METHODS
  Women undergoing indicated CVS signed informed consent. Randomisation after decision to perform transcervical CVS.
  
  
  METHODS
  
  
  
  METHODS
  the rise in maternal serum alpha-fetoprotein (alpha-FP).
  
  
  RESULTS
  (i) placental trauma (fetomaternal haemorrhage [FMH]); (ii) laboratory, procedure, and cytogenetic results and pregnancy outcomes; (iii) patient and operator satisfaction; and (iv) economic analyses. Analyses were performed by intention to treat.
  
  
  RESULTS
  The -FP rise did not differ between groups; there was no other evidence of placental trauma. BF were better tolerated by women, provided culturable tissue, after fewer instrument passes, with greater ease and in less time. BF were associated with cost savings.
  
  
  CONCLUSIONS
  Unlike -FP, other markers of FMH were unaltered, questioning the reliability of alpha-FP as an indicator of FMH. Compared with CA, transcervical BF caused comparable placental trauma, appeared to be similarly effective and safe and were preferred by operators and patients.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Peter
authors.initials: P
authors.lastname: von Dadelszen
authors.forename: Mathew
authors.initials: M
authors.lastname: Sermer
authors.forename: Joan
authors.initials: J
authors.lastname: Hillier
authors.forename: Lynn C
authors.initials: LC
authors.lastname: Allen
authors.forename: Bernie J J
authors.initials: BJ
authors.lastname: Fernandes
authors.forename: Jo-Ann M
authors.initials: JA
authors.lastname: Johnson
authors.forename: Jerry
authors.initials: J
authors.lastname: Shime
authors.forename: Elizabeth J T
authors.initials: EJ
authors.lastname: Winsor
authors.forename: Greg
authors.initials: G
authors.lastname: Ryan
mesh_terms: D001707:Biopsy, Needle / Q000295:instrumentation* / Q000379:methods / Q000592:standards; D002404:Catheterization / Q000592:standards*; D015193:Chorionic Villi Sampling / Q000295:instrumentation* / Q000379:methods / Q000592:standards; D020732:Cytogenetic Analysis; D004867:Equipment Design; D005260:Female; D005331:Fetomaternal Transfusion / Q000209:etiology; D006801:Humans; D009772:Obstetrical Forceps; D017060:Patient Satisfaction; D011247:Pregnancy; D011256:Pregnancy Outcome; D013525:Surgical Instruments / Q000592:standards*; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D000509:alpha-Fetoproteins