Subchronic treatment with imipramine ameliorates the decreased number in neuropeptide Y-positive cells in the hippocampus of learned helplessness rats.
Learned helplessness, but not immobilization stress, decreased the numbers of neuropeptide Y (NPY)-positive cells (interneuron), but not calcitonin gene-related peptide (CGRP)-positive cells (mossy cell), in the hilus of the hippocampus. Subchronic treatment of learned helplessness rats, but not naive rats, with imipramine ameliorated the decrease in the number of NPY-positive cells. Therefore, NPY-positive cells in the hippocampus may contribute to depression.
Ishida
Hisahito
H
Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Japan.
Shirayama
Yukihiko
Y
Iwata
Masaaki
M
Kawahara
Ryuzou
R
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage*; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism; D002452:Cell Count; D004334:Drug Administration Schedule; D006380:Helplessness, Learned; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D007099:Imipramine / Q000008:administration & dosage*; D007395:Interneurons / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009478:Neuropeptide Y / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012149:Restraint, Physical / Q000502:physiology
D000929:Antidepressive Agents, Tricyclic; D009478:Neuropeptide Y; D015740:Calcitonin Gene-Related Peptide; D007099:Imipramine