Activation of Bax by BH3 domains during apoptosis: the unfolding of a deadly plot.
The BH3-only proteins are intracellular death ligands that are critical for initiating apoptosis. Their mode of action is dependent upon the ability of their BH3 domain to interact with pro- and anti-apoptotic multi-domain members of the Bcl-2 family. Direct agonists of the pro-apoptotic multi-domain protein Bax, and other BH3-only proteins, induce Bax activation and apoptosis by independent, yet cooperative, pathways.
Juin
Philippe
P
Equipe 4, Apoptose et Progression Tumorale, INSERM U601, Nantes, France. PhilippeJuin@univ-nantes.fr
Cartron
Pierre François
PF
Vallette
François M
FM
D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000502:physiology*; D051023:BH3 Interacting Domain Death Agonist Protein / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics; D051028:bcl-2-Associated X Protein / Q000737:chemistry / Q000235:genetics / Q000502:physiology*
D051023:BH3 Interacting Domain Death Agonist Protein; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein