title: Predicting depression following mild traumatic brain injury.
abstract: BACKGROUND
  Minimizing negative consequences of major depression following traumatic brain injury is an important public health objective. Identifying high-risk patients and referring them for treatment could reduce morbidity and loss of productivity.
  
  
  OBJECTIVE
  To develop a model for early screening of patients at risk for major depressive episode at 3 months after traumatic brain injury.
  
  
  METHODS
  Prediction model using receiver operating characteristic curve.
  
  
  METHODS
  Level I trauma center in a major metropolitan area.
  
  
  METHODS
  Prospective cohort of 129 adults with mild traumatic brain injury.
  
  
  METHODS
  Center for Epidemiologic Studies Depression Scale score and current major depressive episode module of the Structured Clinical Interview for the DSM-IV.
  
  
  RESULTS
  A prediction model including higher 1-week Center for Epidemiologic Studies Depression Scale score, older age, and computed tomographic scans of intracranial lesions yielded 93% sensitivity and 62% specificity.
  
  
  CONCLUSIONS
  This study supports the feasibility of identifying patients with mild traumatic brain injury who are at high risk for developing major depressive episode by 3 months' postinjury, which could facilitate selective referral for potential treatment and reduction of negative outcomes.
authors.affiliation: Physical Medicine and Rehabilitation Alliance, Baylor College of Medicine, University of Texas-Houston Medical School, TX 77030, USA. hlevin@bcm.tmc.edu
authors.forename: Harvey S
authors.initials: HS
authors.lastname: Levin
authors.forename: Stephen R
authors.initials: SR
authors.lastname: McCauley
authors.forename: Claudia Pedroza
authors.initials: CP
authors.lastname: Josic
authors.forename: Corwin
authors.initials: C
authors.lastname: Boake
authors.forename: Sharon A
authors.initials: SA
authors.lastname: Brown
authors.forename: Heather S
authors.initials: HS
authors.lastname: Goodman
authors.forename: Shirley G
authors.initials: SG
authors.lastname: Merritt
authors.forename: Susan I
authors.initials: SI
authors.lastname: Brundage
mesh_terms: D000328:Adult; D000553:Ambulatory Care; D001930:Brain Injuries / Q000150:complications / Q000175:diagnosis*; D015331:Cohort Studies; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods; D015233:Models, Statistical; D011336:Probability; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D012372:ROC Curve; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000706:statistics & numerical data; D014193:Trauma Centers / Q000458:organization & administration; D015599:Trauma Severity Indices