A case of long QT syndrome associated with familial occurrence of persistent patency of the arterial duct.
We describe an occurrence of long QT syndrome in association with persistent patency of the arterial duct in members of a family. Patency of the arterial duct was diagnosed in family members of 4 successive generations. The index case had long QT syndrome associated with such a patent duct. Another patient had long QT syndrome, but associated with a ventricular septal defect. We postulate that there may be a common genetic mechanism for long QT syndrome and persistent patency of the arterial duct.
Murugan
Subramanian Jothi
SJ
Department of Congenital Heart Disease and Clinical Genetics, Leeds General Infirmary, Leeds, United Kingdom. jothidevi1@hotmail.com
Parsons
Jonathan M
JM
Bennett
Chris
C
D001146:Arrhythmia, Sinus / Q000209:etiology; D001919:Bradycardia / Q000209:etiology; D002648:Child; D004374:Ductus Arteriosus, Patent / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008133:Long QT Syndrome / Q000209:etiology*; D010375:Pedigree; D013575:Syncope / Q000209:etiology