Ovarian cancer metastasis: integrating insights from disparate model organisms.
Despite considerable efforts to improve early detection, and advances in chemotherapy, metastasis remains a major challenge in the clinical management of ovarian cancer. Studies of new murine models are providing novel insights into the pathophysiology of ovarian cancer, but these models are not readily amenable to genetic screens. Genetic analysis of border-cell migration in the Drosophila melanogaster ovary provides clues that will improve our understanding of ovarian cancer metastasis at the molecular level, and also might lead to potential therapeutic targets.
Naora
Honami
H
Department of Molecular Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Montell
Denise J
DJ
D000818:Animals; D001201:Ascites / Q000209:etiology; D015820:Cadherins / Q000502:physiology; D002448:Cell Adhesion; D002465:Cell Movement; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D006133:Growth Substances / Q000502:physiology; D023421:Models, Animal; D009362:Neoplasm Metastasis / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000473:pathology*; D010053:Ovary / Q000166:cytology; D015398:Signal Transduction
D015820:Cadherins; D006133:Growth Substances