title: Psychological status and depression in patients with liver cirrhosis.
abstract: BACKGROUND
  Previous studies reported an impairment of both the physical and mental dimensions of quality of life in patients with cirrhosis. Very few data are available on the psychological impact of the disease and its relation to liver function.
  
  
  OBJECTIVE
  To measure the psychological status of patients with cirrhosis in relation to the severity of the liver impairment.
  
  
  METHODS
  One hundred and fifty-six patients with cirrhosis were studied. Two questionnaires (the Beck Depression Inventory and the Psychological General Well-Being Index) were self-administered in random order. Clinical and laboratory data were collected using standardised forms.
  
  
  RESULTS
  The global score of Psychological General Well-Being Index was severely reduced compared to Italian population norm. Among individual domains, the more severely affected was General Health, the less compromised was Positive Well-Being. A negative relation was found between Child-Pugh score (a comprehensive measure of disease severity) and global Psychological General Well-Being Index and several individual subscales. The Beck Depression Inventory scores were indicative of a depressed mood in over 50% of patients, in relation to the presence of clinical symptoms.
  
  
  CONCLUSIONS
  Patients with cirrhosis have signs of psychological distress and depression, as assessed by Beck Depression Inventory and Psychological General Well-Being Index, in relation to the severity of liver disease. Accordingly, a non-negligible number of patients warrant treatment.
authors.affiliation: Department of Internal Medicine, Cardioangiology, Hepatology, Alma Mater Studiorum University of Bologna, S. Orsola-Malpighi Hospital, Via Massarenti 9, I-40138 Bologna, Italy. giampaolo.bianchi@unibo.it
authors.forename: G
authors.initials: G
authors.lastname: Bianchi
authors.forename: G
authors.initials: G
authors.lastname: Marchesini
authors.forename: F
authors.initials: F
authors.lastname: Nicolino
authors.forename: R
authors.initials: R
authors.lastname: Graziani
authors.forename: D
authors.initials: D
authors.lastname: Sgarbi
authors.forename: C
authors.initials: C
authors.lastname: Loguercio
authors.forename: R
authors.initials: R
authors.lastname: Abbiati
authors.forename: M
authors.initials: M
authors.lastname: Zoli
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000523:psychology; D003863:Depression / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000523:psychology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D012720:Severity of Illness Index; D012893:Sleep Wake Disorders / Q000523:psychology; D013315:Stress, Psychological / Q000175:diagnosis*; D011795:Surveys and Questionnaires