title: Cremastrine, a pyrrolizidine alkaloid from Cremastra appendiculata.
abstract: A new pyrrolizidine alkaloid, cremastrine (1), was isolated from the bulbs of Cremastra appendiculata. Its configuration was determined by spectroscopic and chemical analyses. Compound 1 inhibited the binding of tritium-labeled N-methylscopolamine to the muscarinic M3 receptor with a K(i) value of 126 nM.
authors.affiliation: Pharmaceuticals Research Unit, Mitsubishi Pharma Corporation, 2-25-1, Shodai-Ohtani, Hirakata, Osaka 573-1153, Japan. Ikeda.Yoshitaka@mc.m-pharma.co.jp
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Hikaru
authors.initials: H
authors.lastname: Nonaka
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Furumai
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Igarashi
mesh_terms: D007564:Japan; D015394:Molecular Structure; D019832:N-Methylscopolamine / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D029595:Orchidaceae / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D011763:Pyrrolizidine Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000493:pharmacokinetics / Q000494:pharmacology; D043587:Receptor, Muscarinic M3 / Q000378:metabolism*
chemical_list: D011763:Pyrrolizidine Alkaloids; D043587:Receptor, Muscarinic M3; C500674:cremastrine; D019832:N-Methylscopolamine