title: Annonaceous acetogenins: the hydroxyl groups and THF rings are crucial structural elements for targeting the mitochondria, demonstration with the synthesis of fluorescent squamocin analogues.
authors.affiliation: Laboratoire de Pharmacognosie associé au CNRS, UMR 8076, Centre d'Etudes Pharmaceutiques, Université Paris-Sud 11, 5, rue Jean-Baptiste Clément, 92296 Châtenay-Malabry Cedex, France.
authors.forename: Séverine
authors.initials: S
authors.lastname: Derbré
authors.forename: Gaël
authors.initials: G
authors.lastname: Roué
authors.forename: Erwan
authors.initials: E
authors.lastname: Poupon
authors.forename: Santos A
authors.initials: SA
authors.lastname: Susin
authors.forename: Reynald
authors.initials: R
authors.lastname: Hocquemiller
mesh_terms: D054378:Acetogenins; D029061:Annonaceae / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D001391:Azo Compounds / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D005233:Fatty Alcohols / Q000737:chemistry* / Q000494:pharmacology; D005453:Fluorescence; D005663:Furans / Q000138:chemical synthesis* / Q000494:pharmacology; D017665:Hydroxyl Radical / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D013050:Spectrometry, Fluorescence
chemical_list: D054378:Acetogenins; D000972:Antineoplastic Agents, Phytogenic; D001391:Azo Compounds; D004791:Enzyme Inhibitors; D005233:Fatty Alcohols; D005663:Furans; D007783:Lactones; C059660:squamocin; D017665:Hydroxyl Radical