title: Candidal arthritis after complete treatment of systemic candidiasis.
abstract: Over the last few decades, the incidence of invasive candidal infections in neonatal intensive care units has increased dramatically. Various complications, such as arthritis, endocarditis, meningitis, and endophthalmitis, have been reviewed. We present the case of a premature infant with systemic candidemia. Arthritis was discovered 6 months after completion of amphotericin B therapy, and was successfully treated with oral fluconazole for 6 weeks. We conclude that long-term follow-up is particularly important in patients with treated candidemia. To prevent complications, prolonged treatment with high-dose amphotericin B is suggested for systemic fungal infection, and oral fluconazole is an effective alternative for candidal arthritis.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Far Eastern Memorial Hospital, Panchiao, Taipei, Taiwan, ROC.
authors.forename: Wen-Bin
authors.initials: WB
authors.lastname: Hsieh
authors.forename: Cheung
authors.initials: C
authors.lastname: Leung
mesh_terms: D000666:Amphotericin B / Q000009:adverse effects* / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001168:Arthritis / Q000139:chemically induced* / Q000188:drug therapy; D002177:Candidiasis / Q000188:drug therapy*; D016640:Diabetes, Gestational; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D007717:Knee / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D011247:Pregnancy; D011859:Radiography; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole