Synthesis and biological evaluation of gemcitabine-lipid conjugate (NEO6002).
A novel gemcitabine-lipid conjugate 5 was synthesized and tested for its in vivo efficacy and toxicity. Compound 5 was tested in BxPC-3 human pancreatic tumor model in SCID mice and exhibited promising activity and lower toxicity when compared with Gemzar.
Ali
Shoukath M
SM
NeoPharm Inc., Research and Development Facility, 1850 Lakeside Drive, Waukegan, IL 60085, USA.
Khan
Abdul R
AR
Ahmad
Moghis U
MU
Chen
Paul
P
Sheikh
Saifuddin
S
Ahmad
Imran
I
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008055:Lipids / Q000138:chemical synthesis* / Q000494:pharmacology*; D051379:Mice; D016513:Mice, SCID; D000093542:Gemcitabine
D000970:Antineoplastic Agents; D008055:Lipids; D003841:Deoxycytidine; D000093542:Gemcitabine