title: A randomized prospective study of microdose leuprolide versus ganirelix in in vitro fertilization cycles for poor responders.
abstract: Forty-eight patients who met the criteria of poor response during prior gonadotropin stimulation were enrolled in a randomized prospective study comparing a gonadotropin-releasing hormone (GnRH) antagonist protocol, using ganirelix acetate, with a microdose GnRH agonist protocol for in vitro fertilization-embryo transfer (IVF-ET). This pilot study contributes to the literature of poor response IVF treatment protocols because the use of ganirelix appears to be as effective as the microdose protocol and may be a superior choice in terms of cost and convenience for the patient.
authors.affiliation: The Center for Advanced Reproductive Services, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Connecticut Health Center, Farmington, Connecticut 06030-6224, USA.
authors.forename: David W
authors.initials: DW
authors.lastname: Schmidt
authors.forename: Terry
authors.initials: T
authors.lastname: Bremner
authors.forename: John J
authors.initials: JJ
authors.lastname: Orris
authors.forename: Donald B
authors.initials: DB
authors.lastname: Maier
authors.forename: Claudio A
authors.initials: CA
authors.lastname: Benadiva
authors.forename: John C
authors.initials: JC
authors.lastname: Nulsen
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods* / Q000706:statistics & numerical data; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D016729:Leuprolide / Q000008:administration & dosage*; D010865:Pilot Projects; D011247:Pregnancy; D011446:Prospective Studies
chemical_list: D007987:Gonadotropin-Releasing Hormone; D016729:Leuprolide; C061018:ganirelix