Rhodium-catalyzed addition of arylzinc reagents to aryl alkynyl ketones: synthesis of beta,beta-disubstituted indanones.
A rhodium-catalyzed addition of arylzinc reagents to aryl alkynyl ketones for the synthesis of highly substituted indanones has been developed. The key to success has proved to be a proper choice of the reaction system, which involves the employment of dppf as a ligand and 1,2-dichloroethane as a solvent.
Shintani
Ryo
R
Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Japan.
Hayashi
Tamio
T