Rhodium-catalyzed intramolecular conjugate addition of vinylstannanes to 2,3-dihydro-4-pyridones. An efficient route to stereoselective construction of indolizidines.
[reaction: see text] [RhCl(cod)](2) is an effective catalyst for the intramolecular conjugate addition of vinylstannanes to 2,3-dihydro-4-pyridones under neutral conditions at room temperature. The reaction occurs in good yields, giving indolizidine skeletons with excellent diastereoselectivity. A stereochemical outcome observed in these cyclizations is proposed.
Dziedzic
Magdalena
M
Institute of Organic Chemistry, Polish Academy of Sciences, 01-224 Warsaw, Poland.
Małecka
Marta
M
Furman
Bartłomiej
B