Neonatal brain: regional variability of in vivo MR imaging relaxation rates at 3.0 T--initial experience.
OBJECTIVE
To retrospectively investigate regional in vivo magnetic resonance (MR) imaging transverse and longitudinal relaxation rates at 3.0 T in neonatal brain, the relationship between these rates, and their potential use for gray matter (GM) versus white matter (WM) tissue discrimination.


METHODS
Informed parental consent for performance of imaging procedures was obtained in each infant. Informed consent for retrospective image analysis was not required; ethics approval was obtained from institutional review board. At 3.0 T, R1 and R2 were measured in brain regions (frontal WM, posterior WM, periventricular WM, frontal GM, posterior GM, basal ganglia, and thalamus) in 13 infants with suspected neurologic abnormality (two term, 11 preterm). Maps of R1 and R2 were acquired with T1 by multiple readout pulses and segmented spin-echo echo-planar imaging sequences, respectively. Accuracy of R1 and R2 map acquisition methods was tested in phantoms by comparing them with inversion-recovery and spin-echo sequences, respectively. Statistical analysis included linear regression analysis to determine relationship between R1 and R2 and Wilcoxon signed rank test to investigate the potential for discrimination between GM and WM.


RESULTS
In phantoms, R1 values measured with T1 by multiple readout pulses sequence were 3%-8% lower than those measured with inversion recovery sequence, and R2 values measured with segmented echo-planar sequence were 1%-8% lower than those measured with spin-echo sequence. A strong correlation of 0.944 (P < .001) between R1 and R2 in neonatal brain was observed. For R2, relative differences between GM and WM were larger than were those for R1 (z = -2.366, P < .05). For frontal GM and frontal WM, (R2(GM) - R2(WM))/R2(WM) yielded 0.8 +/- 0.2 (mean +/- standard deviation) and (R1(GM) - R1(WM))/R1(WM) yielded 0.3 +/- 0.09.


CONCLUSIONS
Results at 3.0 T indicate that R1 decreases with increasing field strength, while R2 values are similar to those reported at lower field strengths. For neonates, R2 image contrast may be more advantageous than R1 image contrast for differentiation between GM and WM.
Williams
Lori-Anne
LA
Imaging Division, Lawson Health Research Institute, London, Ontario, Canada. lwilliams@lri.sjhc.london.on.ca
Gelman
Neil
N
Picot
Paul A
PA
Lee
David S
DS
Ewing
James R
JR
Han
Victor K
VK
Thompson
R Terry
RT
D001921:Brain / Q000473:pathology*; D001927:Brain Diseases / Q000151:congenital* / Q000175:diagnosis; D001931:Brain Mapping; D004292:Dominance, Cerebral / Q000502:physiology; D017352:Echo-Planar Imaging; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis*; D007969:Leukomalacia, Periventricular / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D019047:Phantoms, Imaging; D012016:Reference Values; D012044:Regression Analysis; D012189:Retrospective Studies