[Synthesis, spectral characterization and bioactivity of complexes of furoylpyrazolone-thiosemicarbazone].
A new Schiff base containing sulphur, 1-phenyl-3-methyl-4-(alpha-furoyl) pyrazolone-5-thiosemicarbazone (HL) and its Zn(II), Cd(II) and Co(II) complexes have been synthesized. On the basis of elemental analysis and molar conductance, the general formulae of the complexes, [ZnL2] x 1.5H2O, [CdL2] x C2H5OH and [CoL2] x H2O, were given. They were characterized by IR, UV-Visible, 1H NMR, 13C NMR and magnetic moments. The results show that the metal ions exhibit coordination of six in the complexes. The antibacterial experiments indicate that they have high antibacterial activities against S. aureus, B. subtilis, E. coli, E. carotovora, and C. flaccumfaciens.
Li
Jin-zhou
JZ
Department of Chemistry, Harbin Normal University, Harbin 150080, China.
Zhang
Guang-lin
GL
Sha
Jing-quan
JQ
An
Yu-mei
YM
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects / Q000254:growth & development; D002104:Cadmium / Q000737:chemistry; D003035:Cobalt / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008280:Magnetics; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D047069:Pyrazolones / Q000737:chemistry*; D012545:Schiff Bases / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013696:Temperature; D013882:Thiosemicarbazones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D015032:Zinc / Q000737:chemistry
D000900:Anti-Bacterial Agents; D009942:Organometallic Compounds; D047069:Pyrazolones; D012545:Schiff Bases; D013882:Thiosemicarbazones; D002104:Cadmium; C038362:pyrazolone; D003035:Cobalt; D015032:Zinc