title: Abnormal effective connectivity of dopamine D2 receptor binding in schizophrenia.
abstract: Receptor binding has been examined region by region in both in vitro and in vivo studies, but less attention has been paid to the connectivity of regional receptor binding despite the fact that neurophysiological studies have indicated an extensive inter-regional connectivity. In this study, we investigated the connectivity of regional dopamine D2 receptor binding in positron emission tomography data from 10 drug-naive patients with schizophrenia and 19 healthy controls. We applied a structural equation method to regional receptor binding. The results indicated that the network models of the patients and normal subjects were significantly different. As to the individual path coefficients, (a) connectivity between cortical regions was different between groups; (b) connectivity from the prefrontal cortex, parietal cortex, and thalamus to the anterior cingulate differed from that in controls; and (c) connectivity from the prefrontal cortex to the anterior cingulate and thalamus via the hippocampus was observed in normal subjects but not in patients. These results suggest that a systems-level change reflected in the connectivity of D2 receptor binding is present in schizophrenia.
authors.affiliation: Brain Imaging Project, National Institute of Radiological Sciences, Inage-ku, Chiba 263-8555, Japan.
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Yasuno
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Suhara
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Okubo
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ichimiya
authors.forename: Akihiro
authors.initials: A
authors.lastname: Takano
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Sudo
authors.forename: Makoto
authors.initials: M
authors.lastname: Inoue
mesh_terms: D000328:Adult; D001665:Binding Sites; D001921:Brain / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D010054:Brief Psychiatric Rating Scale; D006179:Gyrus Cinguli / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D066298:In Vitro Techniques; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000503:physiopathology*; D010296:Parietal Lobe / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D049268:Positron-Emission Tomography; D017397:Prefrontal Cortex / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D012559:Schizophrenia / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology; D012720:Severity of Illness Index; D013788:Thalamus / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology
chemical_list: D017448:Receptors, Dopamine D2