title: Comprehensive two-dimensional liquid chromatography and hyphenated liquid chromatography to study the degradation of poly(bisphenol A)carbonate.
abstract: Size exclusion chromatography (SEC), gradient polymer elution chromatography (GPEC) and liquid chromatography at critical conditions (LC-CC) have been developed and applied to observe chemical changes in poly(bisphenol A)carbonate (PC) due to hydrolytic degradation. Especially LC-CC appeared to be very successful to observe differences in functionality of PC as result of hydrolytic degradation. Observed differences due to degradation could be identified by (semi) on-line coupling to matrix assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF-MS). The differences in functionality could be attributed to the formation of different end-groups, i.e. OH end-groups. In addition, comprehensive two-dimensional liquid chromatography (2D-LC) has been applied successfully to study the hydrolytic degradation of PC. LC-CC x SEC showed that the formation of PC with different end-groups occurred over the whole molecular mass range. This information could not be obtained with the separate liquid chromatographic techniques, thereby illustrating the added value of 2D-LC.
authors.affiliation: Packaging Research and Polymer Analysis Group, Analytical Sciences Department, TNO Quality of Life, Utrechtseweg 48, 3704 HE Zeist, The Netherlands. coulier@voeding.tno.nl
authors.forename: L
authors.initials: L
authors.lastname: Coulier
authors.forename: E R
authors.initials: ER
authors.lastname: Kaal
authors.forename: Th
authors.initials: T
authors.lastname: Hankemeier
mesh_terms: D001559:Benzhydryl Compounds; D002850:Chromatography, Gel / Q000379:methods*; D011108:Polymers / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013056:Spectrophotometry, Ultraviolet; D000098826:Bisphenol A Compounds; D000098827:Polycarbonates
chemical_list: D001559:Benzhydryl Compounds; D011108:Polymers; C028237:bisphenol-A-polycarbonate; D000098826:Bisphenol A Compounds; D000098827:Polycarbonates