Influence of the R22H variant of macrophage inflammatory protein 1beta/Lag-1 in HIV-1 survival.
The chemokine macrophage inflammatory protein 1beta/CCL4, ligand of the major HIV co-receptor CCR5, is encoded by two genes, Act-2 and Lag-1. Our work focused on R22H, a variant of Lag-1 located near the N-loop, in the 310 turn, a domain essential for interacting with CCR5. We observed that HIV-1-infected patients from the SEROCO cohort, bearing the R22H variant either at the homozygous or heterozygous state, exhibit a worse global survival compared with wild-type homozygous individuals.
Capoulade-Métay
Corinne
C
INSERM U543, CHU Pitié-Salpétrière, Paris, France.
Meyer
Laurence
L
Tran
Ton
T
Persoz
Anne
A
Bourdais
Anne
A
Dudoit
Yasmine
Y
Delfraissy
Jean-François
JF
Debré
Patrice
P
Theodorou
Ioannis
I
D054407:Chemokine CCL4; D015331:Cohort Studies; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology / Q000401:mortality; D015497:HIV-1; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D019402:Macrophage Inflammatory Proteins / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D019713:Receptors, CCR5 / Q000378:metabolism; D016019:Survival Analysis
D054407:Chemokine CCL4; D019402:Macrophage Inflammatory Proteins; D019713:Receptors, CCR5