title: Peptide-oligonucleotide conjugates for the delivery of antisense and siRNA.
abstract: Conjugation of oligonucleotides to certain types of peptides provides an interesting approach for enhancing delivery of antisense and siRNA to cells and tissues. This article will provide a perspective on issues in oligonucleotide delivery, and will examine recent literature on the preparation and use of several types of peptide-oligonucleotide conjugates.
authors.affiliation: University of North Carolina, Department of Pharmacology, School of Medicine, Chapel Hill, NC 27599, USA. arjay@med.unc.edu
authors.forename: Rudolph L
authors.initials: RL
authors.lastname: Juliano
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D006801:Humans; D016376:Oligonucleotides, Antisense / Q000008:administration & dosage*; D010455:Peptides; D034741:RNA, Small Interfering / Q000008:administration & dosage*
chemical_list: D016376:Oligonucleotides, Antisense; D010455:Peptides; D034741:RNA, Small Interfering