title: Clinical utility of lipoarabinomannan antibody in pleural fluid for the diagnosis of tuberculous pleurisy.
abstract: We studied the clinical utility of the detection of lipoarabinomannan antibody, using MycoDot, in pleural fluid for the diagnosis of tuberculous pleurisy. Nine patients with active tuberculous pleurisy, 1 patient with chronic tuberculous empyema, and 16 patients with nontuberculous pleural effusions were studied. The results were positive in 5 patients with tuberculous pleural disease. Sensitivity was 50% (5 of 10; including the 1 patient with chronic tuberculous empyema) and specificity was 93.8% (15 of 16). Detection of lipoarabinomannan antibody using MycoDot in pleural fluid is a specific diagnostic tool for tuberculous pleurisy; furthermore, this diagnostic method is simple, rapid, and cost-effective.
authors.affiliation: First Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan. tyokoyama@cogeco.ca
authors.forename: Toshinobu
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Toru
authors.initials: T
authors.lastname: Rikimaru
authors.forename: Takashi
authors.initials: T
authors.lastname: Kinoshita
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kamimura
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Oshita
authors.forename: Hisamichi
authors.initials: H
authors.lastname: Aizawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000032:analysis*; D005260:Female; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010996:Pleural Effusion / Q000382:microbiology*; D014396:Tuberculosis, Pleural / Q000175:diagnosis*
chemical_list: D000907:Antibodies, Bacterial; D008070:Lipopolysaccharides; C050016:lipoarabinomannan