title: Histologic chorioamnionitis and severity of illness in very low birth weight newborns.
abstract: OBJECTIVE
  Estimating the risk of in-hospital mortality in the neonatal intensive care unit provides important information for health care providers, and several neonatal illness severity scores have been developed. Histologic chorioamnionitis (HCA) is a known cause of neonatal morbidity and mortality. To date, the relationship between HCA and neonatal illness severity scores has not been rigorously tested. In this study, the relationships among HCA, initial illness severity, and neonatal outcomes were analyzed in very low birth weight (VLBW) newborns admitted to the neonatal intensive care unit.
  
  
  METHODS
  Prospective.
  
  
  METHODS
  Neonatal intensive care unit.
  
  
  METHODS
  A total of 116 VLBW inborn infants (gestational age, 28.1 +/- 2.82 wks; birth weight, 1009 +/- 312 g) were categorized as HCA-positive (n = 67) and HCA-negative (n = 49).
  
  
  METHODS
  Placental histology was performed to identify HCA. Illness severity evaluation included several different neonatal illness severity scores-Clinical Risk Index for Babies (CRIB), CRIB-II, Score for Neonatal Acute Physiology-II (SNAP-II), and Score for Neonatal Acute Physiology Perinatal Extension-II (SNAPPE-II)-as well as the recording of severe morbidity and in-hospital mortality.
  
  
  RESULTS
  HCA-positive VLBW newborns showed significantly lower gestational age (p < .0001) and birth weight (p = .0010), together with higher CRIB, CRIB-II, SNAP-II, and SNAPPE-II scores at admission to the NICU (p </= .0001) and mortality rate (p = .0018) than HCA-negative infants. After adjustment for gender and gestational age in a multivariable logistic regression analysis, HCA was found to be an independent predictor of high illness severity: CRIB > 5 (odds ratio [OR], 21.37; 95% confidence interval [CI], 6.24-73.21); CRIB-II > 10 (OR, 56.17; 95% CI, 6.75-467.2); SNAP-II > 22 (OR, 43.05; 95% CI, 11.9-155.7), and SNAPPE-II > 42 (OR, 48.95; 95% CI, 10.18-235.4) (all p values <.0001).
  
  
  CONCLUSIONS
  Our findings indicate that HCA is a major predictor of morbidity and mortality in VLBW newborns.
authors.affiliation: Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Policlinico Le Scotte, Viale M. Bracci 16, I-53100 Siena, Italy. defelice.claudio@libero.it
authors.forename: Claudio
authors.initials: C
authors.lastname: De Felice
authors.forename: Paolo
authors.initials: P
authors.lastname: Toti
authors.forename: Stefano
authors.initials: S
authors.lastname: Parrini
authors.forename: Antonio
authors.initials: A
authors.lastname: Del Vecchio
authors.forename: Franco
authors.initials: F
authors.lastname: Bagnoli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Latini
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Kopotic
mesh_terms: D002821:Chorioamnionitis / Q000453:epidemiology* / Q000401:mortality; D005260:Female; D005865:Gestational Age; D017052:Hospital Mortality; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D008297:Male; D011237:Predictive Value of Tests; D011247:Pregnancy; D011446:Prospective Studies; D012720:Severity of Illness Index; D012737:Sex Factors