MicroRNA biogenesis: coordinated cropping and dicing.
The recent discovery of microRNAs (miRNAs) took many by surprise because of their unorthodox features and widespread functions. These tiny, approximately 22-nucleotide, RNAs control several pathways including developmental timing, haematopoiesis, organogenesis, apoptosis, cell proliferation and possibly even tumorigenesis. Among the most pressing questions regarding this unusual class of regulatory miRNA-encoding genes is how miRNAs are produced in cells and how the genes themselves are controlled by various regulatory networks.
Kim
V Narry
VN
Department of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Seoul, 151-742, Korea. narrykim@snu.ac.kr
D000818:Animals; D005786:Gene Expression Regulation; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics* / Q000378:metabolism; D010944:Plants / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
D035683:MicroRNAs