title: Escherichia coli: development of carbapenem resistance during therapy.
abstract: A 76-year-old woman had recurrent urosepsis due to extended-spectrum beta -lactamase-positive Escherichia coli. Imipenem resistance was detected after long-term imipenem-meropenem therapy. The carbapenem-hydrolyzing enzyme gene was identified as blaKPC-3. To our knowledge, this is the first documented case in which carbapenem-resistant E. coli emerged during therapy with imipenem and meropenem, and the first identification of the carbapenem-hydrolyzing enzyme in E. coli isolates.
authors.affiliation: Hackensack University Medical Center, Hackensack, NJ 07601, USA. thong@humed.com
authors.forename: Tao
authors.initials: T
authors.lastname: Hong
authors.forename: Ellen Smith
authors.initials: ES
authors.lastname: Moland
authors.forename: Baha
authors.initials: B
authors.lastname: Abdalhamid
authors.forename: Nancy D
authors.initials: ND
authors.lastname: Hanson
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.forename: Cindy
authors.initials: C
authors.lastname: Sloan
authors.forename: Diane
authors.initials: D
authors.lastname: Fabian
authors.forename: Awny
authors.initials: A
authors.lastname: Farajallah
authors.forename: Jerome
authors.initials: J
authors.lastname: Levine
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Thomson
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000382:microbiology*; D005260:Female; D006801:Humans; D015378:Imipenem / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D013845:Thienamycins / Q000008:administration & dosage / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D013845:Thienamycins; D015378:Imipenem; D000077731:Meropenem