title: C-glycosylflavones from the aerial parts of Eleusine indica inhibit LPS-induced mouse lung inflammation.
abstract: The infusion of aerial parts (EI) of Eleusine indica Gaertn (Poaceae) is used in Brazil against airway inflammatory processes like influenza and pneumonia. Pre-treatment with 400 mg/kg of crude extract inhibited 98% of lung neutrophil recruitment in mice exposed to aerosols of lipopolysaccharide (LPS) from Gram-negative bacteria, in a dose-dependent manner. At 400 microg/kg, schaftoside (6-C-beta-glucopyranosyl-8-C-alpha-arabinopyranosylapigenin) and vitexin (8-C-beta-glucopyranosylapigenin), isolated from EI, inhibited 62% and 80% of lung neutrophil influx, respectively. These results may justify the popular use of E. indica against airway inflammatory processes.
authors.affiliation: Núcleo de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Giany O
authors.initials: GO
authors.lastname: De Melo
authors.forename: Michelle F
authors.initials: MF
authors.lastname: Muzitano
authors.forename: Alexandre
authors.initials: A
authors.lastname: Legora-Machado
authors.forename: Thais A
authors.initials: TA
authors.lastname: Almeida
authors.forename: Daniela B
authors.initials: DB
authors.lastname: De Oliveira
authors.forename: Carlos R
authors.initials: CR
authors.lastname: Kaiser
authors.forename: Vera Lucia G
authors.initials: VL
authors.lastname: Koatz
authors.forename: Sônia S
authors.initials: SS
authors.lastname: Costa
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D031748:Eleusine; D047309:Flavones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D008070:Lipopolysaccharides; D008171:Lung Diseases / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D047309:Flavones; D008070:Lipopolysaccharides; D010936:Plant Extracts