title: Dihydropyrimidinase-related protein 2 (DRP-2) gene and association to deficit and nondeficit schizophrenia.
abstract: A previous study has shown an association between the *2236T > C allele polymorphism of the dihydropyrimidinase-related protein 2 (DRP-2) gene and schizophrenia in a Japanese sample [Nakata et al. (2003); Biological Psychiatry 53:571-576]. DRP-2 is an important molecule in guiding neuronal development and its gene is located in 8p21, a chromosomal region that was previously shown to have significant linkage to schizophrenia and to several deficit symptoms of schizophrenia. We compared the frequency of the DRP-2 *2236T > C polymorphism between subjects with (n = 117) and without (n = 72) schizophrenia, and then further evaluated whether the association was specific for the deficit (n = 24) and nondeficit (n = 93) forms of schizophrenia. In both Caucasians and African-Americans, the C allele occurred more frequently in schizophrenia cases than controls, with this difference achieving statistical significance in Caucasians (C allele frequency: 42.0% in cases vs. 25.0% in controls, P = 0.014) but not African Americans (52.6% in cases vs. 50.0% in controls, P = 0.93). In Caucasians, the frequency of the C allele was significantly higher in both the deficit (allele frequency 53.3%, P = 0.009) and nondeficit (39.2%, P =0.050) forms of schizophrenia compared to controls (allele frequency 25.0%). We conclude that the DRP-2 *2236 C allele may mark another polymorphism in DRP-2, or in a nearby gene, that may influence susceptibility to schizophrenia.
authors.affiliation: Department of Psychiatry, Maryland Psychiatric Research Center, School of Medicine, University of Maryland, Baltimore, 21228, USA. ehong@mprc.umaryland.edu
authors.forename: L Elliot
authors.initials: LE
authors.lastname: Hong
authors.forename: Ikwunga
authors.initials: I
authors.lastname: Wonodi
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Avila
authors.forename: Robert W
authors.initials: RW
authors.lastname: Buchanan
authors.forename: Robert P
authors.initials: RP
authors.lastname: McMahon
authors.forename: Braxton D
authors.initials: BD
authors.lastname: Mitchell
authors.forename: O Colin
authors.initials: OC
authors.lastname: Stine
authors.forename: William T
authors.initials: WT
authors.lastname: Carpenter
authors.forename: Gunvant K
authors.initials: GK
authors.lastname: Thaker
mesh_terms: D000328:Adult; D001741:Black or African American / Q000235:genetics; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D009419:Nerve Tissue Proteins; D011506:Proteins; C095114:collapsin response mediator protein-2