Leptolide, a new furanocembranolide diterpene from Leptogorgia alba.
Six furanocembranolides (1-6) and one pseudopterolide (7) have been isolated from the octocorals Leptogorgia alba and Leptogorgia rigida, collected on the Pacific coast of Panama. Compound 1, named leptolide, has a new structure closely related to the neurotoxin lophotoxin (3). The X-ray structures of 1-3 were determined, and the absolute configurations of 2-7 are discussed. Compounds 1-7 were evaluated in vitro against drug-resistant Plasmodium falciparum.
Gutiérrez
Marcelino
M
Departamento de Química Orgánica, Instituto de Acuicultura y Unidad de RMN de Biomoléculas Asociada al CSIC, Universidad de Santiago de Compostela, E-15782 Santiago de Compostela, Spain.
Capson
Todd L
TL
Guzmán
Héctor M
HM
González
José
J
Ortega-Barría
Eduardo
E
Quiñoá
Emilio
E
Riguera
Ricardo
R
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D001952:Bridged-Ring Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004351:Drug Resistance; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D010140:Pacific Ocean; D010176:Panama; D010963:Plasmodium falciparum / Q000187:drug effects*
D001952:Bridged-Ring Compounds; D004224:Diterpenes; D005663:Furans; D007783:Lactones; C447624:furanocembranolide; C501150:leptolide; C074182:pseudopterolide