title: Lysosomal evaluation of endometrioma capsule epithelium and endometrium of patients with or without endometriosis.
abstract: OBJECTIVE
  To evaluate the number of lysosomes in glandular epithelia of the endometrioma capsule and endometrium from patients with or without endometriosis using a histochemical method (acidic phosphate determination) under light microscopy.
  
  
  METHODS
  We studied 31 selected patients with similar clinical features, except for the occurrence of menorrhagia enhanced in patients with endometriosis. All patients were submitted to video laparoscopic procedures and endometrial biopsies through hysteroscopy during the secretory phase. After surgery, the patients were divided into two groups for hysteroscopic data: GI--without endometriosis (control, n = 16) and GII--with endometriosis (n = 15). In GII, the lysosomes of the endometrioma were also counted (GIIa).
  
  
  RESULTS
  The GI sample was comprised only of endometrial biopsies. We found that the number of lysosomes in the topic endometrial tissue of patients with endometriosis was significantly larger than the number in endometrioma. Also, there were more lysosomes in the endometrium of patients with endometriosis than in endometrioma-bearing patients.
  
  
  CONCLUSIONS
  Our data suggest that variations in the number of lysosomes may underlie the pathogenesis of endometriosis.
authors.affiliation: Gynecology Department, Federal University of São Paulo, Escola Paulista de Medicina, Brazil.
authors.forename: E V
authors.initials: EV
authors.lastname: von Adamek
authors.forename: M J
authors.initials: MJ
authors.lastname: Simões
authors.forename: V
authors.initials: V
authors.lastname: Freitas
authors.forename: M T
authors.initials: MT
authors.lastname: Patriarca
authors.forename: J M
authors.initials: JM
authors.lastname: Soares
authors.forename: E C
authors.initials: EC
authors.lastname: Baracat
mesh_terms: D000328:Adult; D001706:Biopsy; D016022:Case-Control Studies; D002452:Cell Count; D004715:Endometriosis / Q000473:pathology* / Q000601:surgery; D004717:Endometrium / Q000473:pathology*; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D008183:Luteal Phase / Q000502:physiology; D008247:Lysosomes / Q000473:pathology*; D011446:Prospective Studies