title: G309D and W437OPA PINK1 mutations in Caucasian Parkinson's disease patients.
abstract: OBJECTIVE
  To determine whether the G309D and W437OPA mutations in PINK1 gene are present in American Caucasian population of patients with Parkinson's disease (PD).
  
  
  METHODS
  We searched for the G309D and W437OPA mutation by sequencing the regions of interest in the PINK1 gene in 237 unrelated Caucasian patients.
  
  
  RESULTS
  None of the 237 samples showed the G309D or W437OPA mutations.
  
  
  CONCLUSIONS
  The G309D and W437OPA mutations in PINK1 gene probably do not represent common causes of familial or sporadic PD in a Caucasian population.
authors.affiliation: Department of Neurology, Parkinson's Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: H
authors.initials: H
authors.lastname: Deng
authors.forename: W D
authors.initials: WD
authors.lastname: Le
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: T H
authors.initials: TH
authors.lastname: Pan
authors.forename: J
authors.initials: J
authors.lastname: Jankovic
mesh_terms: D000328:Adult; D019943:Amino Acid Substitution; D004252:DNA Mutational Analysis; D005260:Female; D005820:Genetic Testing; D015894:Genome, Human; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D010300:Parkinson Disease / Q000208:ethnology* / Q000235:genetics* / Q000378:metabolism; D011494:Protein Kinases / Q000235:genetics*; D014481:United States; D044465:White People / Q000235:genetics*; D000099202:PTEN-Induced Putative Kinase
chemical_list: D011494:Protein Kinases; D000099202:PTEN-Induced Putative Kinase