title: Hypercalcemia in a patient with common variable immunodeficiency and renal granulomas.
abstract: Common variable immunodeficiency (CVID) is the most common primary immunodeficiency. A granulomatous form of the condition is recognized. Renal involvement is rare. The authors present the first case of CVID with biopsy-proven noncaseating renal granulomas, in association with hypercalcemia. The mechanism of hypercalcemia in granulomatous disorders, and the difficulty of differentiating granulomatous CVID from sarcoidosis, are discussed.
authors.affiliation: Department of Nephrology and Immunology, and Histopathology, Royal Free Hospital, London, United Kingdom. ameyer@doctors.net.uk
authors.forename: Alex
authors.initials: A
authors.lastname: Meyer
authors.forename: Helen J
authors.initials: HJ
authors.lastname: Lachmann
authors.forename: A David
authors.initials: AD
authors.lastname: Webster
authors.forename: Aine
authors.initials: A
authors.lastname: Burns
authors.forename: Khin
authors.initials: K
authors.lastname: Thway
mesh_terms: D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000188:drug therapy / Q000628:therapy; D003937:Diagnosis, Differential; D004893:Erythema Nodosum / Q000209:etiology; D006099:Granuloma / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology* / Q000503:physiopathology; D016756:Immunoglobulins, Intravenous; D007674:Kidney Diseases / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D012507:Sarcoidosis / Q000175:diagnosis; D013163:Splenomegaly / Q000209:etiology
chemical_list: D016756:Immunoglobulins, Intravenous; D011239:Prednisolone