[Cytofluorimetric assay for evaluation of CD16 receptor expression and myeloperoxidase (MPO) activity of neutrophils in patients with psoriasis vulgaris treated with PUVA].
Early histological changes indicate the collecting of neutrophils in the stratum corneum, mainly in the acute psoriasis. Fc gammaRIIIB (CD16) is the specific functional neutrophilic receptor, which is responsible for phagocytosis. Myeloperoxidase (MPO) is granulocyte enzyme playing main role in metabolic activity of neutrophils. We have evaluated CD16 expression and MPO activity of polymorphonuclear granulocytes in the acute psoriasis vulgaris and the influence of photochemotherapy PUVA (psoralen plus ultraviolet light of A wavelength) treatment on these parameters. The expression of CD16 and MPO activity were significantly higher in neutrophils of patients after PUVA.
Kapuścińska
Renata
R
Zakładu Laboratoryjnej Diagnostyki Pediatrycznej, Akademii Medycznej w Białymstoku. zldpam@poczta.fm
Wysocka
Jolanta
J
Niczyporuk
Wiaczesław
W
Ratomski
Karol
K
D000208:Acute Disease; D000328:Adult; D005260:Female; D005434:Flow Cytometry / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000201:enzymology*; D011701:PUVA Therapy / Q000379:methods*; D009195:Peroxidase / Q000378:metabolism*; D011565:Psoriasis / Q000276:immunology / Q000378:metabolism / Q000628:therapy; D017452:Receptors, IgG / Q000276:immunology* / Q000378:metabolism*
D017452:Receptors, IgG; D009195:Peroxidase