Cytotoxic chromenes from Myriactis humilis.
Two new chromenes, myriachromene and 2,2-dimethyl-6,7-methylenedioxy-2H-chromene, together with ten known compounds including alpha-tocopherylquinone, alpha-tocopherol acetate, diphenyl sulfone, beta-carotene, chondrillasterol, beta-sitosterol, beta-sitostenone, vanillin, and vanillic acid were isolated from the whole plant of Myriactis humilis. The structures of these new compounds were determined through spectral analyses. Among the isolates, four compounds exhibited cytotoxicity (ED50 values < 4 microg/mL) against P-388 or HT-29 cell lines in vitro.
Chen
Jih-Jung
JJ
Department of Pharmacy, Tajen Institute of Technology, Pingtung, Taiwan, Republic of China. jjchen@ccsun.tajen.edu.tw
Duh
Chang-Yih
CY
Chen
Ih-Sheng
IS
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D019659:Asteraceae; D001578:Benzopyrans / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects; D019073:HT29 Cells / Q000187:drug effects; D006801:Humans; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018514:Plant Structures
D000972:Antineoplastic Agents, Phytogenic; D001578:Benzopyrans; D010936:Plant Extracts