Cochlin deposits in the trabecular meshwork of the glaucomatous DBA/2J mouse.
Cochlin deposits were observed in the trabecular meshwork (TM) of 8-month-old glaucomatous DBA/2J mice, coincident with the reported onset of increased intraocular pressure and optic nerve damage. An age-dependent increase in cochlin was observed up to 10 months of age and was paralleled by a decrease in type II collagen. Similar expression patterns exist in the TM of humans with primary open-angle glaucoma. Cochlin deposits, absent in non-glaucomatous mouse and human TM, may disrupt the TM extracellular matrix and obstruct aqueous humor circulation. Studies of DBA/2J mice offer promise for understanding the role cochlin may play in glaucoma.
Bhattacharya
Sanjoy K
SK
Annangudi
Suresh P
SP
Salomon
Robert G
RG
Kuchtey
Rachel W
RW
Peachey
Neal S
NS
Crabb
John W
JW
D000375:Aging; D000818:Animals; D003094:Collagen / Q000378:metabolism; D016326:Extracellular Matrix Proteins; D005902:Glaucoma, Open-Angle / Q000378:metabolism*; D051379:Mice; D008811:Mice, Inbred DBA; D023421:Models, Animal; D011506:Proteins / Q000378:metabolism*; D014129:Trabecular Meshwork / Q000378:metabolism*
C491729:Coch protein, mouse; D016326:Extracellular Matrix Proteins; D011506:Proteins; D003094:Collagen