[The role of ghrelin in the regulation of energy homeostasis].
Ghrelin, a novel 28 amino acid peptide, is the endogenous ligand for the growth hormone secretagogue receptor. The stomach is the primary source of circulating ghrelin, but it is also produced by the intestines, kidneys, hypothalamus, pituitary, placenta and pancreas. Ghrelin has been recognized as an important regulator of GH secretion and have important roles in energy homeostasis, glucose and lipid metabolism, reproduction, cardiovascular function, and immunity. Ghrelin has been shown to have a physiological role in the control of food intake, acting as an orexigenic hormone, probably by stimulating NPY production in contrast to the actions of leptin.
Otto Buczkowska
Ewa
E
Górnoślaskie Centrum Zdrowia Dziecka i Matki w Katowicach, Katowice. em.buczkowski@pro.onet.pl
D001066:Appetite / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D054439:Ghrelin; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D036361:Peptide Hormones / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D054440:Receptors, Ghrelin
D054439:Ghrelin; D036361:Peptide Hormones; D043562:Receptors, G-Protein-Coupled; D054440:Receptors, Ghrelin; D013006:Growth Hormone