title: Methotrexate-induced bullous acral erythema in a child.
abstract: Chemotherapy induced acral erythema (CIAE) is an uncommon and dramatic reaction to high-dose chemotherapy. It is characterized by symmetrical, well-demarcated, painful erythema of the palms and soles which may progress to bullae formation and desquamation. Prompt recognition and discrimination from more serious conditions such as graft-vs-host disease or toxic epidermal necrolysis is essential. This paper describes the case of a 12-year-old boy who developed CIAE after high-dose methotrexate treatment and discusses the important clinical, histopathological, and therapeutic features of this condition.
authors.affiliation: Department of Dermatology, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. werchniak@comcast.net
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Werchniak
authors.forename: Sara
authors.initials: S
authors.lastname: Chaffee
authors.forename: James G H
authors.initials: JG
authors.lastname: Dinulos
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D004890:Erythema / Q000139:chemically induced / Q000473:pathology; D005266:Femoral Neoplasms / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D012516:Osteosarcoma / Q000188:drug therapy*; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000473:pathology
chemical_list: D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate