Bilateral breast-conserving therapy for bilateral breast cancer: results and consideration of radiation technique.
BACKGROUND
Although breast-conserving surgery followed by definitive irradiation is an established treatment for patients with early breast cancer, the role of breast-conserving therapy (BCT) for patients with bilateral breast cancer has not been well studied and the radiation therapy technique is still under investigation. We examined the feasibility of breast-conserving therapy for bilateral breast cancer and present here our radiation therapy technique with CT simulator.


METHODS
Between July 1990 and December 1998, we treated 17 patients with bilateral breast cancer who underwent bilateral breast-conserving surgery followed by definitive irradiation. Seven patients had synchronous bilateral breast cancer and ten had metachronous bilateral breast cancer. Radiation therapy consisted of 50 Gy to the bilateral whole breast in all patients but one. A CT simulator was used to plan a tangential radiation field to the breast in all patients. Boost irradiation of 10 Gy was administered to 8 tumors with close or positive margins.


RESULTS
With a median follow-up periods of 95 months from each operation, no patients showed loco-regional recurrence on either side, and none suffered distant metastasis. Furthermore no serious late adverse effects were observed.


CONCLUSIONS
This study demonstrated that BCT is feasible for bilateral breast cancer and the CT simulator is useful for determining the radiation field, especially when lesions are metachronous.
Yamauchi
Chikako
C
Department of Therapeutic Radiology and Oncology Graduate School of Medicine, Kyoto University 54 Kawahara-cho, Shogoin, Sakyo, Kyoto, 606-8507, Japan. chikay@kuhp.kyoto-u.ac.jp
Mitsumori
Michihide
M
Nagata
Yasushi
Y
Kokubo
Masaki
M
Inamoto
Takashi
T
Mise
Keiichi
K
Kodama
Hiroshi
H
Hiraoka
Masahiro
M
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental / Q000379:methods*; D008875:Middle Aged; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome