title: [Rhabdomyolysis after administration of diclofenac].
abstract: Rhabdomyolysis may develop after various traumatic and nontraumatic circumstances. The use of lipid-lowering statins as well as the abuse of stimulants such as methylendioxymethamphetamine (ecstasy) can lead to fatal rhabdomyolysis with acute renal failure. We describe a case of diclofenac-induced rhabdomyolysis after a cumulative dose of 200 mg per os with consecutive critical increase of the creatine kinase and myoglobin. Prescription of diclofenac should therefore be done with caution. In cases of emergent myalgias, immediate testing of creatine kinase and myoglobin is mandatory to exclude fatal rhabdomyolysis with acute renal failure.
authors.affiliation: Unfallchirurgische Klinik, Medizinische Hochschule Hannover, Hannover. kknobi@yahoo.com
authors.forename: K
authors.initials: K
authors.lastname: Knobloch
authors.forename: D
authors.initials: D
authors.lastname: Rossner
authors.forename: T
authors.initials: T
authors.lastname: Gössling
authors.forename: A
authors.initials: A
authors.lastname: Lichtenberg
authors.forename: M
authors.initials: M
authors.lastname: Richter
authors.forename: C
authors.initials: C
authors.lastname: Krettek
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000517:prevention & control*; D000328:Adult; D003402:Creatine Kinase / Q000097:blood*; D004008:Diclofenac / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009211:Myoglobin / Q000097:blood*; D012206:Rhabdomyolysis / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis*
chemical_list: D009211:Myoglobin; D004008:Diclofenac; D003402:Creatine Kinase