title: Genetics and bioinformatics of primary open angle glaucoma: an Indian perspective.
abstract: Glaucoma is the second largest blinding disorder, after cataract, affecting about 67 million people worldwide. In India about 1.5 million people are blind due to glaucoma. Primary open angle glaucoma is the major sub-type of glaucoma affecting all ages and is genetically complex. Myocilin and optineurin are two different genes that have been implicated for primary open angle glaucoma. This review is focused on the studies being conducted in India on primary open angle glaucoma to identify the molecular defects and new directions undertaken using bioinformatic approaches towards a better understanding of the disease.
authors.affiliation: Human Genetics and Genomics Division, Indian Institute of Chemical Biology, Kolkata 700 032.
authors.forename: Kunal
authors.initials: K
authors.lastname: Ray
authors.forename: Sanjay Kumar Daulat
authors.initials: SK
authors.lastname: Thakur
authors.forename: Arun Kumar
authors.initials: AK
authors.lastname: Banerjee
authors.forename: Arijit
authors.initials: A
authors.lastname: Mukhopadhyay
authors.forename: Moulinath
authors.initials: M
authors.lastname: Acharya
authors.forename: Ashima
authors.initials: A
authors.lastname: Bhattacharjee
authors.forename: Abhijit
authors.initials: A
authors.lastname: Sen
authors.forename: Gautam
authors.initials: G
authors.lastname: Bhaduri
mesh_terms: D001766:Blindness / Q000209:etiology / Q000235:genetics; D018797:Cell Cycle Proteins; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D019295:Computational Biology; D003598:Cytoskeletal Proteins / Q000235:genetics; D005136:Eye Proteins / Q000235:genetics; D005902:Glaucoma, Open-Angle / Q000145:classification / Q000150:complications / Q000235:genetics*; D006023:Glycoproteins / Q000235:genetics; D006801:Humans; D007194:India; D026901:Membrane Transport Proteins; D035582:Transcription Factor TFIIIA / Q000235:genetics; D014786:Vision Disorders / Q000209:etiology* / Q000235:genetics; D000099179:Myocilin
chemical_list: D018797:Cell Cycle Proteins; D003598:Cytoskeletal Proteins; D005136:Eye Proteins; D006023:Glycoproteins; D026901:Membrane Transport Proteins; D035582:Transcription Factor TFIIIA; D000099179:Myocilin; C409460:OPTN protein, human