title: Influence of the type of operations on the development of latex sensitization in children with myelomeningocele.
abstract: BACKGROUND
  A genetic tendency to develop latex IgE responses in children with spina bifida has been suggested, but their degree of exposure to latex as well as the route and chronology for sensitization can be different from those of other children with multiple surgeries. The aim was to study the influence of the type of operation on the development of latex sensitization in children with myelomeningocele.
  
  
  METHODS
  In 90 children with myelomeningocele operated with latex, data were collected about age, sex, family, and personal history of allergy, serum total IgE, presence of a ventricular-peritoneal (v-p) shunt, and number and duration of operations, classified as urological, orthopedic, on the v-p shunt, other neurosurgical, and others. A multivariate logistic regression analysis was performed, using the presence of latex sensitization as dependent variable.
  
  
  RESULTS
  Serum total IgE, the number of urological and of orthopedic operations were synergistic variables to predict latex sensitization, together with the presence of a v-p shunt, but not the number of operations performed on this device. This seems to play an adjuvant role in the process of sensitization.
  
  
  CONCLUSIONS
  Not only the number, but also the type of operations, namely, of urological and orthopedic nature, is important in the development of latex sensitization in children with myelomeningocele.
authors.affiliation: Section of Pediatric Allergy, Children's Hospital La Fe, 46009 Valencia, Spain.
authors.forename: Angel
authors.initials: A
authors.lastname: Mazon
authors.forename: Antonio
authors.initials: A
authors.lastname: Nieto
authors.forename: Rafael
authors.initials: R
authors.lastname: Pamies
authors.forename: Ruben
authors.initials: R
authors.lastname: Felix
authors.forename: Juan Jose
authors.initials: JJ
authors.lastname: Linana
authors.forename: Amparo
authors.initials: A
authors.lastname: Lanuza
authors.forename: Luis
authors.initials: L
authors.lastname: Caballero
authors.forename: Francisco
authors.initials: F
authors.lastname: Estornell
authors.forename: Fernando
authors.initials: F
authors.lastname: Garcia-Ibarra
authors.forename: Jose A
authors.initials: JA
authors.lastname: Alvarez-Garijo
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D020315:Latex Hypersensitivity / Q000209:etiology*; D008297:Male; D008591:Meningomyelocele / Q000601:surgery*; D015999:Multivariate Analysis; D019637:Orthopedic Procedures; D011183:Postoperative Complications / Q000209:etiology*; D012307:Risk Factors; D013520:Urologic Surgical Procedures; D017287:Ventriculoperitoneal Shunt
chemical_list: D007073:Immunoglobulin E