title: Interrelationship between polymorphisms of incA, fusogenic properties of Chlamydia trachomatis strains, and clinical manifestations in patients in The Netherlands.
abstract: IncA variation among Dutch Chlamydia trachomatis isolates was investigated. Of 98 strains, two carried an incA with a premature stop codon, lacked IncA, and were nonfusogenic, while 96 contained an intact incA, expressed IncA, and were fusogenic. Among these 96 strains, nine IncA sequence types were found, of which the three most frequently encountered (88% of the strains) were randomly distributed among symptomatic and asymptomatic patients.
authors.affiliation: Dept. of Medical Microbiology, Academic Medical Center, University of Amsterdam, Room L1-115, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands. y.pannekoek@amc.uva.nl.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Pannekoek
authors.forename: Joke
authors.initials: J
authors.lastname: Spaargaren
authors.forename: Ankie A J
authors.initials: AA
authors.lastname: Langerak
authors.forename: Judith
authors.initials: J
authors.lastname: Merks
authors.forename: Servaas A
authors.initials: SA
authors.lastname: Morré
authors.forename: Arie
authors.initials: A
authors.lastname: van der Ende
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics*; D002690:Chlamydia Infections / Q000503:physiopathology*; D002692:Chlamydia trachomatis / Q000235:genetics* / Q000302:isolation & purification; D014644:Genetic Variation; D006801:Humans; D009426:Netherlands; D010750:Phosphoproteins / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D001426:Bacterial Proteins; C094163:IncA protein, bacteria; D010750:Phosphoproteins