Orthotopic liver transplantation in U.S. veterans under primary tacrolimus immunosupression.
The evolution and refinement of surgical techniques, per ioperative patient care, and immunosuppression hav~ estab~ished orthoto~ic li~er transplantation (OLTX) as a ~ighly successful therapeutic modality for patients wrth end-stage hver disease. In February 1989,Tacrohmus (Prograf®, formerly FK 506)was first used successfully at the University of Pittsburgh Medical Center to treat patients with rejection refractory to cyclosporine-based immunosuppression." Clinical trials utilizing Tacrolimus in solid organ transplantation followed, and in April of 1994 it was approved for use by the Food and Drug Administration,
Gayowski
T
T
Pittsburgh Transplantation Institute and the Vetrans Administration Medical Center, Pittsburgh, Pennsylvania, USA.
Marino
I R
IR
Singh
N
N
Doyle
H R
HR
Wagener
M M
MM
Todo
S
S
Fung
J J
JJ
Starzl
T E
TE