title: A complex dietary supplement extends longevity of mice.
abstract: Key factors implicated in aging include reactive oxygen species, inflammatory processes, insulin resistance, and mitochondrial dysfunction. All are exaggerated in transgenic growth hormone mice (TGM), which display a syndrome resembling accelerated aging. We formulated a complex dietary supplement containing 31 ingredients known to ameliorate all of the above features. We previously showed that this supplement completely abolished the severe age-related cognitive decline expressed by untreated TGM. Here we report that longevity of both TGM and normal mice is extended by this supplement. Treated TGM showed a 28% increase (p < .00008) in mean longevity. An 11% increase in mean longevity was also significant (p < .002093) for treated normal mice, compared to untreated normal mice. These data support the hypothesis that TGM are a model of accelerated aging, and demonstrate that complex dietary supplements may be effective in ameliorating aging or age-related pathologies where simpler formulations have generally failed.
authors.affiliation: Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1. lemonja@mcmaster.ca
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Lemon
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Boreham
authors.forename: C David
authors.initials: CD
authors.lastname: Rollo
mesh_terms: D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight; D003071:Cognition / Q000187:drug effects* / Q000502:physiology; D016001:Confidence Intervals; D019587:Dietary Supplements; D004195:Disease Models, Animal; D005260:Female; D008136:Longevity / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018384:Oxidative Stress / Q000502:physiology; D011336:Probability; D012680:Sensitivity and Specificity