title: Antiganglion neuron antibodies correlate with neuropathy in Sjögren's syndrome.
abstract: To investigate the possible implication of antibodies against dorsal root ganglion neuron in the pathogenesis of sensory neuropathy with Sjögren's syndrome, we examined the pathogenic role of antiganglion neuron antibodies by immunoblotting, immunohistochemistry and immunoreactive assay. Sjögren's syndrome patients without neuropathy, patients with vasculitic neuropathy and normal volunteers were evaluated as controls. Antiganglion neuron antibodies recognizing certain proteins of several different molecular weights were detected only in patients of sensory neuropathy with Sjögren's syndrome. Those antibodies labeled specific-sized neurons in the fixed ganglion and isolated ganglion neurons under the culture condition, each of which corresponded well to clinical manifestations. These results suggest that antiganglion neuron antibodies may contribute to the pathogenesis of sensory neuropathy with Sjögren's syndrome.
authors.affiliation: Division of Neurology, Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan 520-2192.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Murata
authors.forename: Kengo
authors.initials: K
authors.lastname: Maeda
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Kawai
authors.forename: Tomoya
authors.initials: T
authors.lastname: Terashima
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Okabe
authors.forename: Atsunori
authors.initials: A
authors.lastname: Kashiwagi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yasuda
mesh_terms: D000368:Aged; D000818:Animals; D001323:Autoantibodies / Q000097:blood*; D002478:Cells, Cultured; D005260:Female; D005727:Ganglia, Spinal / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009443:Neuritis / Q000276:immunology / Q000473:pathology; D009475:Neurons, Afferent / Q000276:immunology / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012859:Sjogren's Syndrome / Q000276:immunology* / Q000473:pathology*; D014985:Xerophthalmia / Q000473:pathology; D014987:Xerostomia / Q000473:pathology
chemical_list: D001323:Autoantibodies