Observation of unaveraged giant MEG activity from language areas during speech tasks in patients harboring brain lesions very close to essential language areas: expression of brain plasticity in language processing networks?
We describe a series of 12 patients who suffered from lesions adjacent to the classic Broca and Wernicke areas and were examined by magnetoencephalography (MEG) for presurgical language localization while performing a protocol of different language tasks. In these patients very large MEG activity of up to 5pT was observed, which was located not only in the adjacent language processing brain areas but also in more distant areas, which are part of the language processing neuronal network. The high amplitude and the focal spatial extent of this activity allowed MEG source localization from the unaveraged data. In nine patients sources of this high amplitude activity were even found in the homologous language areas on the contralateral, the nondominant side of the brain. The physiological interrelationship of these large MEG changes needs to be investigated in more detail in further studies especially in the context of possible mechanisms for brain plasticity to overcome inhibitory activity of the impaired language area.
Grummich
Peter
P
Biomagnetism Group, University of Erlangen-Nürnberg, Schwabachanlage 6, 91054 Erlangen, Germany. peter.grummich@neurozentrum.imed.uni-erlangen.de
Nimsky
Christopher
C
Fahlbusch
Rudolf
R
Ganslandt
Oliver
O
D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D001930:Brain Injuries / Q000473:pathology / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006801:Humans; D007802:Language; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged; D009473:Neuronal Plasticity / Q000502:physiology*; D013067:Speech Perception / Q000502:physiology*; D013997:Time Factors