Identification of chemokine receptor CCR4 antagonist.
The present study reports the identification and hits to leads optimization of chemokine receptor CCR4 antagonists. Compound 12 is a high affinity, non-cytotoxic antagonist of CCR4 that blocks the functional activity mediated by the receptor.
Purandare
Ashok V
AV
Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543, USA. ashok.purandare@bms.com
Gao
Aiming
A
Wan
Honghe
H
Somerville
John
J
Burke
Christine
C
Seachord
Carrie
C
Vaccaro
Wayne
W
Wityak
John
J
Poss
Michael A
MA
D054398:Receptors, CCR4; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors* / Q000502:physiology; D013329:Structure-Activity Relationship
D054398:Receptors, CCR4; D019707:Receptors, Chemokine