Imaging of photodynamically generated singlet oxygen luminescence in vivo.
We describe a novel scanning-laser system for imaging type-II photodynamically generated singlet oxygen (1O2[1delta(g)]) luminescence and demonstrate it in vivo in an intradermal tumor model in mice. We verify the strong oxygen-dependence of the signal and show that the images are near the practical resolution limit.
Niedre
Mark J
MJ
Department of Medical Biophysics, Ontario Cancer Institute and University of Toronto, Toronto, Ontario, Canada.
Patterson
Michael S
MS
Giles
Anoja
A
Wilson
Brian C
BC
D008027:Light; D008163:Luminescent Measurements; D026082:Singlet Oxygen
D026082:Singlet Oxygen