University of Wisconsin solution versus Celsior solution in clinical pancreas transplantation.
BACKGROUND
This study compared the safety and efficacy of University of Wisconsin solution (UW) and Celsior solution (C) in pancreas transplantation (PTx).


METHODS
A retrospective review of 154 PTx performed over a 61-month period included 77 grafts preserved with UW and 77 with C. The two groups were comparable for both donor and recipient characteristics.


RESULTS
After a mean cold ischemia time of 624 minutes (range 360 to 945 minutes) for UW versus 672 minutes (range 415 to 1005 minutes) for C (P = NS), no primary endocrine nonfunction occurred. Delayed endocrine function was diagnosed in two grafts in the UW group (2.6%) versus none in the C group (P = NS). After a minimum follow-up of 4 months (mean 26.5 +/- 15.2 months), 22 recipients (UW = 11 vs C = 11; P = NS) required relaparotomy. Overall, 18 pancreata were lost due to either patient death with functioning graft (UW = 4 vs C = 1; P = NS) or graft loss due to other reasons (UW = 8 vs C = 5; P = NS). Actuarial 1- and 5-year patient survival rates were 93.5% and 86.8% for UW compared with 98.7% and 98.7% for C (P = .04). Actuarial graft survival rates at the same times were 88.3% and 75.0% for UW compared with 90.4% and 90.4% for C (P = NS).


CONCLUSIONS
Within the range of cold ischemia times reported in this study, UW and C show similar safety and efficacy profiles for PTx.
Boggi
U
U
Centro Regionale di Riferimento per la Cura delle Malattie del Pancreas, University of Pisa, Pisa, Italy.
Signori
S
S
Vistoli
F
F
Del Chiaro
M
M
Pietrabissa
A
A
Croce
C
C
Barsotti
M
M
Bartolo
T Vanadia
TV
Amorese
G
G
Capocasale
E
E
Della Valle
R
R
Mazzoni
M P
MP
Mosca
F
F
D000241:Adenosine; D000328:Adult; D000493:Allopurinol; D001787:Blood Group Incompatibility; D002102:Cadaver; D002423:Cause of Death; D004187:Disaccharides; D004573:Electrolytes; D005260:Female; D005971:Glutamates; D005978:Glutathione; D006639:Histidine; D006801:Humans; D007328:Insulin; D007558:Italy; D008297:Male; D008353:Mannitol; D019188:Organ Preservation Solutions; D016035:Pancreas Transplantation / Q000706:statistics & numerical data*; D011183:Postoperative Complications; D011887:Raffinose; D012189:Retrospective Studies; D014019:Tissue Donors / Q000706:statistics & numerical data*; D017211:Treatment Failure
C088453:Celsior; D004187:Disaccharides; D004573:Electrolytes; D005971:Glutamates; D007328:Insulin; D019188:Organ Preservation Solutions; C055206:University of Wisconsin-lactobionate solution; D008353:Mannitol; D006639:Histidine; D000493:Allopurinol; D005978:Glutathione; D000241:Adenosine; D011887:Raffinose