G309D and W437OPA PINK1 mutations in Caucasian Parkinson's disease patients.
OBJECTIVE
To determine whether the G309D and W437OPA mutations in PINK1 gene are present in American Caucasian population of patients with Parkinson's disease (PD).


METHODS
We searched for the G309D and W437OPA mutation by sequencing the regions of interest in the PINK1 gene in 237 unrelated Caucasian patients.


RESULTS
None of the 237 samples showed the G309D or W437OPA mutations.


CONCLUSIONS
The G309D and W437OPA mutations in PINK1 gene probably do not represent common causes of familial or sporadic PD in a Caucasian population.
Deng
H
H
Department of Neurology, Parkinson's Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, TX 77030, USA.
Le
W D
WD
Zhang
X
X
Pan
T H
TH
Jankovic
J
J
D000328:Adult; D019943:Amino Acid Substitution; D004252:DNA Mutational Analysis; D005260:Female; D005820:Genetic Testing; D015894:Genome, Human; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D010300:Parkinson Disease / Q000208:ethnology* / Q000235:genetics* / Q000378:metabolism; D011494:Protein Kinases / Q000235:genetics*; D014481:United States; D044465:White People / Q000235:genetics*; D000099202:PTEN-Induced Putative Kinase
D011494:Protein Kinases; D000099202:PTEN-Induced Putative Kinase