title: Controlled clinical trial of the effect of a homoeopathic nosode on the somatic cell counts in the milk of clinically normal dairy cows.
abstract: Cows in a 250-cow Holstein-Friesian herd were allocated at random to be treated with either a homoeopathic nosode or a negative control, both treatments being applied by means of an aerosol spray to the vulval mucous membranes. A total of six treatments were given over a period of three days and milk samples were taken for the determination of somatic cell counts (SCC) on days -3, 3, 7, 9, 14, 21 and 28. Individuals applying the treatments or carrying out the SCC determination were unaware of which animals were receiving which treatment. Owing to the wide natural variations in SCC, the trial had only a 71 per cent possibility of detecting a 30 per cent difference in SCC between the two groups. There were no significant differences between the SCC of the two groups on any sample day, but there were significant variations between the SCC on different days (P=0.003) in both groups.
authors.affiliation: Farm Animal Epidemiology and Informatics Unit, Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES.
authors.forename: M A
authors.initials: MA
authors.lastname: Holmes
authors.forename: P D
authors.initials: PD
authors.lastname: Cockcroft
authors.forename: C E
authors.initials: CE
authors.lastname: Booth
authors.forename: M F
authors.initials: MF
authors.lastname: Heath
mesh_terms: D000818:Animals; D002417:Cattle; D002452:Cell Count / Q000662:veterinary; D003612:Dairying; D005260:Female; D006705:Homeopathy; D008414:Mastitis, Bovine / Q000188:drug therapy* / Q000473:pathology; D008419:Materia Medica / Q000494:pharmacology* / Q000627:therapeutic use; D008892:Milk / Q000166:cytology / Q000187:drug effects*; D016896:Treatment Outcome
chemical_list: D008419:Materia Medica