Development of tretinoin gels for enhanced transdermal delivery.
To develop the new gel formulations that show sustained release for a period of time, the bioadhesive carbopol gels containing tretinoin were prepared. The release characteristics of drug from the carbopol gel were studied according to temperature, receptor medium and drug concentration. For the enhancement of its percutaneous absorption, some kinds of penetration enhancer were used. As the concentration of drug increased, the release of drug from the gel increased, showing concentration dependency. The increase of temperature showed the increased drug release, depending on the activation energy of permeation. Among the enhancers used such as the glycols and the non-ionic surfactants, polyoxyethylene 2-oleyl ether showed the best enhancing effect. The carbopol gels of tretinoin containing an enhancer could be developed for the enhanced transdermal delivery of drug.
Shin
Sang-Chul
SC
College of Pharmacy, Chonnam National University, Gwangju, South Korea. shinsc@chonnam.ac.kr
Kim
Hee-Jung
HJ
Oh
In-Joon
IJ
Cho
Cheong-Weon
CW
Yang
Kyu-Ho
KH
D000180:Acrylic Resins; D000279:Administration, Cutaneous; D000465:Algorithms; D000818:Animals; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D004058:Diffusion; D005782:Gels; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007641:Keratolytic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D008297:Male; D011145:Polyvinyls; D051381:Rats; D017207:Rats, Sprague-Dawley; D013696:Temperature; D014212:Tretinoin / Q000008:administration & dosage* / Q000493:pharmacokinetics*
D000180:Acrylic Resins; D005782:Gels; D007641:Keratolytic Agents; D011145:Polyvinyls; C006912:carboxypolymethylene; D014212:Tretinoin