Involvement of the inferior frontal junction in cognitive control: meta-analyses of switching and Stroop studies.
There is growing evidence that a specific region in the posterior frontolateral cortex is involved intimately in cognitive control processes. This region, located in the vicinity of the junction of the inferior frontal sulcus and the inferior precentral sulcus, was termed the inferior frontal junction (IFJ). The IFJ was shown to be involved in the updating of task representations and to be activated commonly in a within-subject investigation of a task-switching paradigm, the Stroop task, and a verbal n-back task. Here, we investigate the involvement of the IFJ in cognitive control by employing a meta-analytic approach. Two quantitative meta-analyses of functional magnetic resonance imaging (fMRI) studies were conducted. One meta-analysis included frontal activations from task-switching, set-shifting, and stimulus-response (S-R) reversal studies, the other included frontal activations from color-word Stroop studies. Results showed highly significant clustering of activations in the IFJ in both analyses. These results provide strong evidence for the consistent involvement of the IFJ in both switching and Stroop paradigms. Furthermore, they support our concept of areal specialization in the frontolateral cortex, which posits that it is not only the middorsolateral part that plays an important role in cognitive control, but also the IFJ. Finally, our results demonstrate how quantitative meta-analyses can be used to test hypotheses about the involvement of specific brain regions in cognitive control.
Derrfuss
Jan
J
Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. j.derrfuss@fz-juelich.de
Brass
Marcel
M
Neumann
Jane
J
von Cramon
D Yves
DY
D001931:Brain Mapping / Q000379:methods*; D003071:Cognition / Q000502:physiology*; D005625:Frontal Lobe / Q000502:physiology*; D006801:Humans; D015201:Meta-Analysis as Topic; D011597:Psychomotor Performance / Q000502:physiology*