title: [Thalidomide therapy for infantile-onset Crohn's disease].
abstract: A 6-month-old boy was diagnosed as having Crohn's disease (CD) by the endoscopic examination. Primary immunodeficiency syndrome was initially suspected due to a refractory infection that occurred just after birth and a family history that his older brother died at the age of 3 months of septicemia associated with perirectal abscess. Thalidomide was used because conventional medical treatment by steroids and immunosuppressives was ineffective. Thalidomide improved the symptoms of diarrhea, abdominal pain, high fever and fistula, and the PCDAI score decreased markedly from 45 to 15. Although thalidomide was discontinued after three months because of the onset of side effects, including edema, rash and the peripheral neuropathy, the effect on the fistula closure was maintained over a long period of time. Further studies will be necessary to determine the dosage of thalidomide that does not elicit side effects, but thalidomide seems to be effective in patients with refractory CD. Infantile CD is very rare and the diagnosis is often delayed. CD is generally resistant to medical treatment. More detailed information of infantile CD will be needed to elucidate the pathogenesis of this disease and progress of treatment. Recently the incidence of inflammatory bowel diseases has increased. CD should be suspected in any infant with the perianal lesion (fissures, fistula, skin tag and abscesses) especially when prolonged gastrointestinal symptoms, stomatitis or fever coexist.
authors.affiliation: Division of Infectious Diseases, Immunology and Allergy, Saitama Children's Medical Center.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kabuki
authors.forename: Chikara
authors.initials: C
authors.lastname: Ogimi
authors.forename: Risa
authors.initials: R
authors.lastname: Tanaka
authors.forename: Kaori
authors.initials: K
authors.lastname: Ikematsu
authors.forename: Kohsuke
authors.initials: K
authors.lastname: Joh
authors.forename: Seiichi
authors.initials: S
authors.lastname: Kagimoto
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Oh-Ishi
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D003424:Crohn Disease / Q000188:drug therapy*; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007223:Infant; D000069285:Infliximab; D008297:Male; D013792:Thalidomide / Q000627:therapeutic use*
chemical_list: D000911:Antibodies, Monoclonal; D005765:Gastrointestinal Agents; D007166:Immunosuppressive Agents; D013792:Thalidomide; D000069285:Infliximab