Synthesis of cationic water-soluble light-harvesting dendrimers.
Four generations of phenylenefluorene (1F)- and phenylenebis(fluorene) (2F)-terminated polyamidoamine (PAMAM) dendrimers were synthesized by coupling activated esters with commercially available PAMAM precursors. Treatment of Boc-terminated pendant groups on the optically active units with 3 M HCl in dioxane yields cationic water-soluble dendrimers. Fluorescence resonance energy transfer (FRET) experiments with the cationic dendrimers as the donor and double stranded DNA containing a fluorescein label as the acceptor reveal cooperative optical behavior.
Wang
Shu
S
Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, P. R. China.
Hong
Janice W
JW
Bazan
Guillermo C
GC
D004247:DNA / Q000737:chemistry; D050091:Dendrimers; D019793:Fluorescein / Q000737:chemistry*; D031541:Fluorescence Resonance Energy Transfer; D015394:Molecular Structure; D010777:Photochemistry; D011073:Polyamines / Q000138:chemical synthesis* / Q000737:chemistry; D012997:Solvents; D014867:Water
D050091:Dendrimers; C104700:PAMAM Starburst; D011073:Polyamines; D012997:Solvents; D014867:Water; D004247:DNA; D019793:Fluorescein