Clonal spread of pediatric isolates of ciprofloxacin-resistant, emm type 6 Streptococcus pyogenes.
Twenty-four community isolates of Streptococcus pyogenes resistant to ciprofloxacin and susceptible to levofloxacin, gatifloxacin, and moxifloxacin were studied. Sequence determination of the quinolone resistance-determining regions in the gyrA and parC genes revealed a T/G mutation in parC leading to a Ser79Ala substitution in ParC. All isolates were of the emm type 6, and 18 and 2 of them were indistinguishable or closely related, respectively, on the basis of pulsed-field gel electrophoresis.
Alonso
Rodrigo
R
Departamento de Inmunología, Microbiología y Parasitología, Facultad de Farmacia, Universidad del País Vasco, Paseo de la Universidad, 7 01006-Vitoria-Gasteiz, Spain. oipalmor@vc.ehu.es
Mateo
Estibaliz
E
Galimand
Marc
M
Garaizar
Javier
J
Courvalin
P
P
Cisterna
Ramón
R
D001426:Bacterial Proteins / Q000235:genetics; D002648:Child; D002939:Ciprofloxacin / Q000494:pharmacology*; D017714:Community-Acquired Infections / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D006801:Humans; D012703:Serotyping; D013290:Streptococcal Infections / Q000635:transmission*; D013297:Streptococcus pyogenes / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification*
D001426:Bacterial Proteins; D002939:Ciprofloxacin