[Mercury and neurotoxicity].
OBJECTIVE
Mercury is a metal that is widely used in hundreds of applications nowadays. This metal has proved to be extremely toxic in humans, especially for the central nervous system, both in cases of exposure from everyday applications (e.g. dental fillings) and from environmental exposure. Unfortunately, most of the research carried out on this metal is relatively recent and many questions remain unanswered. The aim of this work is to review all the knowledge we have at the present time about the mechanisms of action of this metal.


METHODS
To do so, we discuss the latest scientific findings about the toxic processes that are activated, as well as its effects on the cellular cytoskeleton, its genotoxicity or the production of compounds that have been linked to neurodegeneration.


CONCLUSIONS
Its prolonged period of latency, ambiguous symptoms and the activation of generalised toxic mechanisms call for urgent efforts to be made in basic research to help determine as clearly as possible the way this metal acts in the body. This knowledge will provide us not only with the way to obtain therapies but also with the hope of developing biomarkers that make it possible to carry out early and reliable diagnoses of the damage done and of individual susceptibility.
Crespo-López
M E
ME
Laboratorio de Biología Celular, Universidade Federal do Pará, Belém, Brazil. ecrespo@ufpa.br
Herculano
A M
AM
Corvelo
T C
TC
Do Nascimento
J L
JL
D017209:Apoptosis / Q000187:drug effects; D015551:Autoimmunity / Q000187:drug effects; D006801:Humans; D008628:Mercury / Q000009:adverse effects*; D020262:Mercury Poisoning, Nervous System / Q000503:physiopathology*; D008870:Microtubules / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects
D008628:Mercury