title: Susceptibility of inbred mouse strains to infection with three species of Metagonimus prevalent in the Republic of Korea.
abstract: Susceptibility of inbred mouse strains to Metagonimus yokogawai, Metagonimus miyatai, and Metagonimus takahashii infections was studied using BALB/c, ddY, C57BL/6J, C3H/HeN, and A/J mice, with H-2 haplotypes d, s, b, k, and a, respectively. Two hundred metacercariae were orally fed to each mouse, and the worm recovery rates (WRR), worm dimensions, and intrauterine egg numbers were measured at days 3, 7, 14, 21, and 28 postinfection (PI). On day 14 PI, the WRR of M. yokogawai was highest in ddY mice (average, 62.2%); those of M. miyatai and M. takahashii were highest in ddY (19.5%) and BALB/c mice (10.4%), respectively; worm maturation was best in C3H/HeN (M. yokogawai), C57BL/6J (M. miyatai), and ddY mice (M. takahashii). All mouse strains showed higher susceptibility to infection with M. yokogawai than with M. miyatai or M. takahashii. The results show that susceptibility of mice to Metagonimus infection varies according to mouse strain and parasite species but is suggested to be independent of the mouse H-2 haplotype.
authors.affiliation: Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul 110-799, South Korea.
authors.forename: Sang-Mee
authors.initials: SM
authors.lastname: Guk
authors.forename: Jin-Young
authors.initials: JY
authors.lastname: Park
authors.forename: Min
authors.initials: M
authors.lastname: Seo
authors.forename: Eun-Taek
authors.initials: ET
authors.lastname: Han
authors.forename: Jae-Lip
authors.initials: JL
authors.lastname: Kim
authors.forename: Jong-Yil
authors.initials: JY
authors.lastname: Chai
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D005298:Fertility; D005399:Fishes; D006239:Haplotypes; D006578:Heterophyidae / Q000254:growth & development / Q000276:immunology / Q000502:physiology*; D006790:Host-Parasite Interactions; D007723:Korea; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains / Q000469:parasitology*; D012741:Sexual Maturation; D014201:Trematode Infections / Q000276:immunology / Q000469:parasitology*