title: Use of amphotericin B lipid complex in elderly patients.
abstract: OBJECTIVE
  The safety and effectiveness of amphotericin B lipid complex (ABLC) treatment in elderly patients was investigated using a large multicenter database.
  
  
  METHODS
  Data analysis was conducted on retrospectively collected patient data from 572 patients >65 years of age and 2930 patients < or =65 years of age treated for fungal infections at 160 North American hospitals.
  
  
  RESULTS
  Patients were typically treated with ABLC for Candidiasis, multiple fungal pathogen infections and Aspergillosis, or were treated empirically. The median cumulative dose of ABLC in patients >65 years of age and those 65 years of age was similar (3000 and 3258 mg, respectively, P=0.127). Despite higher median pretreatment serum creatinine (S-Cr) among patients >65 years of age (1.7 mg/dl vs. 1.4 mg/dl, respectively), both groups showed only a 0.1mg/dl median S-Cr change from baseline by the end of therapy (P=0.525). Clinical response was 56 and 51%, respectively, in patients >65 years of age and patients 65 years of age or younger (P=0.049).
  
  
  CONCLUSIONS
  This study suggests that ABLC can be safely and effectively used in the treatment of invasive fungal disease in elderly patients.
authors.affiliation: ProSanos Corporation, La Jolla CA 92037, USA.
authors.forename: Roya
authors.initials: R
authors.lastname: Hooshmand-Rad
authors.forename: Alice
authors.initials: A
authors.lastname: Chu
authors.forename: Vincent
authors.initials: V
authors.lastname: Gotz
authors.forename: Jonathan
authors.initials: J
authors.lastname: Morris
authors.forename: Scott
authors.initials: S
authors.lastname: Batty
authors.forename: Alison
authors.initials: A
authors.lastname: Freifeld
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000627:therapeutic use*; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D009181:Mycoses / Q000188:drug therapy* / Q000503:physiopathology; D012189:Retrospective Studies
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D003404:Creatinine