Investigation of beta-lactam antibiotic-induced vancomycin-resistant MRSA (BIVR).
We could not detect hetero-vancomycin-intermediate resistant Staphylococcus aureus (hetero-VISA), according to the definition of hetero-VISA, from the clinical isolates of 140 methicillin-resistant S. aureus (MRSA) strains. However, 15 beta-lactam antibiotic-induced vancomycin-resistant MRSA (BIVR) strains were detected from the same strains. We screened 1882 MRSA clinical isolates obtained in 2002 from 21 institutes throughout Japan. The detection rate of blood-isolated BIVR was 12.6% (19/151), and that of nonblood-isolated BIVR was 4.9% (85/1731; P < 0.001; chi2 test). Uridine-diphosphate-N-acetylmuramyl-L: -alanyl-D: -isoglutamyl-L: -lysine, used as the peptidoglycan material of S. aureus, showed the same results as beta-lactam antibiotics in BIVR.
Hanaki
Hideaki
H
Research Center for Anti-infective Drugs, The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-0072, Japan. hanaki@lisci.kitasato-u.ac.jp
Yamaguchi
Yoshio
Y
Yanagisawa
Chie
C
Uehara
Kazuaki
K
Matsui
Hidehito
H
Yamaguchi
Yukie
Y
Hososaka
Yasuko
Y
Barada
Kazunari
K
Sakai
Fumiko
F
Itabashi
Yasuko
Y
Ikeda
Shinsuke
S
Atsuda
Koichiro
K
Tanaka
Haruo
H
Inamatsu
Takashi
T
Nagayama
Ariaki
A
Sunakawa
Keisuke
K
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects*; D020713:Vancomycin Resistance; D047090:beta-Lactams / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D047090:beta-Lactams