title: Changes in the mechanical environment of stenotic arteries during interaction with stents: computational assessment of parametric stent designs.
abstract: Clinical studies have identified factors such as the stent design and the deployment technique that are one cause for the success or failure of angioplasty treatments. In addition, the success rate may also depend on the stenosis type. Hence, for a particular stenotic artery, the optimal intervention can only be identified by studying the influence of factors such as stent type, strut thickness, geometry of the stent cell, and stent-artery radial mismatch with the wall. We propose a methodology that allows a set of stent parameters to be varied, with the aim of evaluating the difference in the mechanical environment within the wall before and after angioplasty with stenting. Novel scalar quantities attempt to characterize the wall changes inform of the contact pressure caused by the stent struts, and the stresses within the individual components of the wall caused by the stent. These quantities are derived numerically and serve as indicators, which allow the determination of the correct size and type of the stent for each individual stenosis. In addition, the luminal change due to angioplasty may be computed as well. The methodology is demonstrated by using a full three-dimensional geometrical model of a postmortem specimen of a human iliac artery with a stenosis using imaging data. To describe the material behavior of the artery, we considered mechanical data of eight different vascular tissues, which formed the stenosis. The constitutive models for the tissue components capture the typical anisotropic, nonlinear and dissipative characteristics under supra-physiological loading conditions. Three-dimensional stent models were parametrized in such a way as to enable new designs to be generated simply with regard to variations in their geometric structure. For the three-dimensional stent-artery interaction we use a contact algorithm based on smooth contact surfaces of at least C-continuity, which prevents numerical problems known from standard facet-based contact algorithm. The proposed methodology has the potential to provide a scientific basis for optimizing treatment procedures and stent geometries and materials, to help stent designers examine new stent designs "virtually," and to assist clinicians in choosing the most suitable stent for a particular stenosis.
authors.affiliation: Institute for Structural Analysis, Computational Biomechanics, Graz University of Technology, 8010 Graz, Schiesstattgasse 14-B, Austria.
authors.forename: Gerhard A
authors.initials: GA
authors.lastname: Holzapfel
authors.forename: Michael
authors.initials: M
authors.lastname: Stadler
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Gasser
mesh_terms: D000328:Adult; D000368:Aged; D001157:Arterial Occlusive Diseases / Q000503:physiopathology* / Q000601:surgery; D001696:Biomechanical Phenomena / Q000379:methods; D001783:Blood Flow Velocity; D001794:Blood Pressure; D001807:Blood Vessel Prosthesis; D002102:Cadaver; D003198:Computer Simulation; D017076:Computer-Aided Design; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D019544:Equipment Failure Analysis / Q000379:methods; D005260:Female; D006801:Humans; D007083:Iliac Artery / Q000503:physiopathology* / Q000601:surgery; D066298:In Vitro Techniques; D008954:Models, Biological; D011474:Prosthesis Design / Q000379:methods*; D015607:Stents; D013813:Therapy, Computer-Assisted / Q000379:methods*