Facile and convenient syntheses of 6,11-dihydro-5H-indeno[1,2-c]isoquinolin- 5-ones and 6,11-dihydro-5H-indolo[3,2-c]isoquinolin-5-one.
[reaction: see text] The synthesis of 6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-ones from the base-promoted condensation reaction of homophthalic anhydride and 2-(bromomethyl)-benzonitrile and a convenient method for the synthesis of indolo[3,2-c]isoquinolinones are described.
Jagtap
Prakash G
PG
Inotek Pharmaceuticals Corporation, 100 Cummings Center, Beverly, Massachusetts 01915, USA. pjagtap@inotekcorp.com
Baloglu
Erkan
E
Southan
Garry
G
Williams
William
W
Roy
Aloka
A
Nivorozhkin
Alexander
A
Landrau
Nelson
N
Desisto
Kevin
K
Salzman
Andrew L
AL
Szabó
Csaba
C
D020650:Combinatorial Chemistry Techniques; D007192:Indenes / Q000138:chemical synthesis*; D007211:Indoles / Q000138:chemical synthesis*; D007546:Isoquinolines / Q000138:chemical synthesis*; D013237:Stereoisomerism
D007192:Indenes; D007211:Indoles; D007546:Isoquinolines