Lignans from Acanthopanax chiisanensis having an inhibitory activity on prostaglandin E2 production.
The chloroform and the ethyl acetate fractions from the roots of Acanthopanax chiisanensis exhibited the significant inhibition of TPA-induced prostaglandin E(2) (PGE(2)) production in rat peritoneal macrophages. Five lignans were isolated from the chloroform fraction and their structures were elucidated as l-sesamin, helioxanthin, savinin, taiwanin C, and 3-(3,4-dimethoxybenzyl)-2-(3,4-methylenedioxybenzyl)butyrolactone. Among the lignans tested, taiwanin C showed the most potent inhibitory activity (IC(50) = 0.12 microM) on PGE(2) production with the relative order of potency, taiwanin C >> 3-(3,4-dimethoxybenzyl)-2-(3,4-methylenedioxybenzyl)butyrolactone > savinin = helioxanthin. l-Sesamin showed no inhibitory activity at 30 microM.
Lee
Sanghyun
S
Natural Products Research Institute, Seoul National University, Korea.
Ban
Hyun Seung
HS
Kim
Yong Pil
YP
Kim
Bak-Kwang
BK
Cho
Seon Haeng
SH
Ohuchi
Kazuo
K
Shin
Kuk Hyun
KH
D000818:Animals; D015232:Dinoprostone / Q000378:metabolism*; D028001:Eleutherococcus; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D017705:Lignans / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D017737:Macrophages, Peritoneal / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D051381:Rats; D017207:Rats, Sprague-Dawley
D004791:Enzyme Inhibitors; D017705:Lignans; D010936:Plant Extracts; D015232:Dinoprostone