title: [Histotopography and density of distribution of the endocrine cells in mucosal epithelium of the large intestine of human fetus].
abstract: Histotopography and density of distribution (DD) of the endocrine cells in the mucosal epithelium of the large intestine of human fetus was studied using light microscopy. Endocrinocyte DD in the mucosal epithelium of the large intestine was found to increase progressively after their first appearance on the 9th week till the 12th week (average DD (164 cells per 1m m2 of mucosal section area--cells/mm2). Subsequently, in the 4th month, the tendency to a reduction of endocrinocyte DD (to 123 cells/mm2) was observed. In the 5th month, a sharp increase of this parameter was detected (reaching 205 cells/mm2), which represented the maximal value during all the periods of intrauterine development studied. In the 6th month cell DD decreased (164 cells/mm2). Dynamics of the changes of EC-cells, with the exception of those ones in the appendix and the rectum, was similar to that observed in the general population of endocrinocytes. In the rectum, EC-cell DD was stable during the 3rd, the 4th and the 5th months, while in the 6th months the tendency to its reduction was observed. In the appendix, the increase of EC-cell DD took place during all periods investigated. The maximal endocrinocyte DD in the epithelium of appendix in prenatal period of ontogenesis points to an essential role of endocrine apparatus function particularly in the intrauterine development.
authors.forename: S V
authors.initials: SV
authors.lastname: Kostiukevich
mesh_terms: D019858:Enteroendocrine Cells / Q000166:cytology*; D005333:Fetus / Q000166:cytology* / Q000196:embryology; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology* / Q000196:embryology; D007420:Intestine, Large / Q000166:cytology* / Q000196:embryology