title: [A case of recurrent breast cancer with bone metastasis causing pancytopenia--efficacy of low-dose CPT-11+ MPA].
abstract: A 46-year-old woman underwent breast-conserving surgery. The patient was treated with six cycles of CMF and, subsequently, combination therapy with UFT and CPA. However, multiple metastases were detected in the thoracic vertebrae after two years and two months of surgery. Weekly administration of paclitaxel was initiated, but the drug could not be continued due to pancytopenia. CPT-11 (40 mg/body) once a week and medroxyprogesterone acetate (MPA) 600 mg a day was substituted for paclitaxel. During the treatment with CPT-11, no severe adverse reactions, such as myelosuppression and diarrhea, were observed, and the patient's condition was stable without discontinuing the chemotherapy. The results suggest that the low-dose CPT-11 and MPA therapy should improve the prognosis of advanced and recurrent breast cancers with only slight adverse effects.
authors.affiliation: Dept of Surgery, Hitoyoshi General Hospital.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Inoue
authors.forename: Masami
authors.initials: M
authors.lastname: Kimura
authors.forename: Kei
authors.initials: K
authors.lastname: Horino
authors.forename: Takumasa
authors.initials: T
authors.lastname: Nishimura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kuhara
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nakano
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kaneda
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kume
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Arima
authors.forename: Kuninori
authors.initials: K
authors.lastname: Uemura
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000556:secondary*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D000077146:Irinotecan; D015412:Mastectomy, Segmental; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage; D008875:Middle Aged; D010198:Pancytopenia / Q000209:etiology*; D011788:Quality of Life
chemical_list: D000077146:Irinotecan; D017258:Medroxyprogesterone Acetate; D002166:Camptothecin