RBM15-MKL1 (OTT-MAL) fusion transcript in an adult acute myeloid leukemia patient.
The t(1;22)(p13;q13) is a nonrandom chromosomal abnormality in acute leukemia with the fusion oncogene, RBM15-MKL1 (OTT-MAL), identified recently. However, this abnormality has been described only in infants and young children with acute megakaryoblastic leukemia (AMKL). We report a 59-year-old male patient with the diagnosis of acute myeloid leukemia, subtype M1, who harbors an abnormal chromosome +der(1)t(1;22)(p13;q13). The RBM15-MKL1 (OTT-MAL) fusion transcript was also confirmed by the reverse transcriptase-polymerase chain reaction. This unusual abnormality is rare in adult cases of leukemia, and in children it is restricted to AMKL. This report is accompanied by a review of the literature on the t(1;22)(p13;q13).
Hsiao
Hui-Hua
HH
Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Yang
Ming-Yu
MY
Liu
Yi-Chang
YC
Hsiao
Hui-Pin
HP
Tseng
Shih-Bin
SB
Chao
Mei-Chyn
MC
Liu
Ta-Chih
TC
Lin
Sheng-Fung
SF
D000208:Acute Disease; D000328:Adult; D001483:Base Sequence; D002878:Chromosomes, Human, Pair 1; D002895:Chromosomes, Human, Pair 5; D017931:DNA Primers; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015534:Trans-Activators; D014178:Translocation, Genetic
D017931:DNA Primers; D004268:DNA-Binding Proteins; C431575:MRTFA protein, human; D015514:Oncogene Proteins, Fusion; C431574:RBM15 protein, human; D016601:RNA-Binding Proteins; D015534:Trans-Activators