title: Lucien J. Rubinstein: enduring contributions to neuro-oncology.
abstract: Dr. Lucien Rubinstein is best remembered for his significant contributions to the field of neuropathology, particularly in the classification of nervous system tumors. His accomplishments in basic neuro-oncology and in the formulation of diagnostic principles reflected a unique talent for synthesizing fundamental clinicopathological concepts based on skillful diagnostic investigation and a thorough understanding of neurobiology. Dr. Rubinstein was the leader in the establishment of cell cultures from central nervous system (CNS) tumors. He meticulously analyzed both light and electron microscopic features of CNS tumors, recorded his findings, and patiently drew sketches to be shared generously with his colleagues and students. As a pioneer in neuropathology, in his work Dr. Rubinstein set the foundation for many enduring concepts in neurosurgery, neuro-oncology, neurology, and basic tumor biology.
authors.affiliation: Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA. mm2ee@hscmail.mcc.virginia.edu
authors.forename: Melike
authors.initials: M
authors.lastname: Mut
authors.forename: M Beatriz S
authors.initials: MB
authors.lastname: Lopes
authors.forename: Mark
authors.initials: M
authors.lastname: Shaffrey
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis / Q000266:history; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000266:history* / Q000503:physiopathology; D003937:Diagnosis, Differential; D049673:History, 20th Century; D006801:Humans; D009462:Neurology / Q000266:history*; D009493:Neurosurgery / Q000266:history; D010336:Pathology / Q000266:history*; D010338:Pathology, Clinical / Q000266:history; D014407:Tumor Cells, Cultured / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor