Anti-inflammatory activity of Cleome gynandra L. on hematological and cellular constituents in adjuvant-induced arthritic rats.
Cleome gynandra L. (cat whiskers) has traditionally been used for the treatment of rheumatic and other inflammatory conditions. In this work, the methanolic extract of the leaves of C. gynandra exhibited significant anti-inflammatory activity in adjuvant-induced arthritic rats. Phytochemical screening was carried out to ascertain the qualitative composition of the leaves. Arthritis was induced by Freund's complete adjuvant. A significant decrease in paw edema with a remarkable increase in body weight was observed following oral administration of the leaf extract (150 mg/kg of body weight). The alterations in hematological and other biochemical parameters were restored to near normal after a treatment period of 30 days. These results demonstrate that the plant extract has no harmful effect and exerts in vivo anti-inflammatory properties against adjuvant-induced arthritis.
Narendhirakannan
R T
RT
Department of Inorganic Chemistry, University of Madras, Chennai, Tamil Nadu, India.
Kandaswamy
M
M
Subramanian
S
S
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000188:drug therapy*; D031485:Cleome / Q000737:chemistry*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005620:Freund's Adjuvant / Q000009:adverse effects; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D005620:Freund's Adjuvant