title: Mass spectrometrical analysis of human serine racemase in foetal brain.
abstract: We analysed human serine racemase for the first time from human foetal brain by mass spectrometrical methods, MALDI MS and MS/MS. The detection of human serine racemase from a transient area of human foetal brain, the perireticular nucleus, that is suggested to be mainly involved in guidance of corticofugal and thalamocortical fibers, may be a clue for the important role of this enzyme in neuronal migration and brain development via regulation of NMDA receptor activity.
authors.affiliation: Department of Pediatrics, Medical University of Vienna, Austria.
authors.forename: F
authors.initials: F
authors.lastname: Hepner
authors.forename: A
authors.initials: A
authors.lastname: Pollak
authors.forename: N
authors.initials: N
authors.lastname: Ulfig
authors.forename: M
authors.initials: M
authors.lastname: Yae-Kyung
authors.forename: G
authors.initials: G
authors.lastname: Lubec
mesh_terms: D000595:Amino Acid Sequence; D001921:Brain / Q000196:embryology* / Q000201:enzymology*; D001923:Brain Chemistry / Q000502:physiology*; D015180:Electrophoresis, Gel, Two-Dimensional; D005333:Fetus; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D019998:Racemases and Epimerases / Q000032:analysis* / Q000235:genetics / Q000378:metabolism; D000099300:Serine Racemase
chemical_list: D019998:Racemases and Epimerases; D000099300:Serine Racemase