Antihepatotoxic effect of beta-carotene on paracetamol induced hepatic damage in rats.
Enzyme levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase (ALP) increased following paracetamol induction were significantly lowered due to pretreatment with the beta-carotene (BC). This supplementation reversed the trend inducing a significant decrease in bilirubin and urea levels. Paracetamol administration significantly reduced hepatic glycogen, glutathione (GSH), glutathione-S-transferase (GST), glutathione peroxidase (GPX) and glutathione reductase (GSH-R). Pretreatment of rats with BC significantly increased the enzyme activities. The results suggest hepatoprotective activity of BC.
Kumar
G
G
Department of Life Science, Selvamm Arts and Science College, Namakkal, India. pgsvedhakumar@yahoo.com
Banu
G Sharmila
GS
Kannan
V
V
Pandian
M Rajasekara
MR
D000082:Acetaminophen / Q000633:toxicity*; D018712:Analgesics, Non-Narcotic / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000517:prevention & control*; D004195:Disease Models, Animal; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D019207:beta Carotene / Q000627:therapeutic use*
D018712:Analgesics, Non-Narcotic; D000975:Antioxidants; D019207:beta Carotene; D000082:Acetaminophen