title: Comparison of blood pressure control with amlodipine and controlled-release isradipine: an open-label, drug substitution study.
abstract: An open-label drug substitution study showed that controlled-release isradipine (Dynacirc-CR) can be safely substituted for amlodipine on a mg-for-mg basis in patients with mild-to-moderate hypertension. When controlled-release isradipine was substituted for amlodipine, blood pressure was more effectively controlled, and edema rates were reduced. When subjects resumed amlodipine therapy, the previous gain in blood pressure reduction and lessening of edema vanished. The basis for this more favorable pattern of efficacy and side-effects with controlled-release isradipine, although mechanistically unresolved, may relate to a lesser degree of sympathetic nervous system activation.
authors.affiliation: Clinical Research Center of Cleveland, CCH-Eastern Region, 13951 Terrace Road, Cleveland, OH 44112, USA. mganz@cchseast.org
authors.forename: Michael
authors.initials: M
authors.lastname: Ganz
authors.forename: Rasoul
authors.initials: R
authors.lastname: Mokabberi
authors.forename: Domenic A
authors.initials: DA
authors.lastname: Sica
mesh_terms: D017311:Amlodipine / Q000627:therapeutic use*; D000704:Analysis of Variance; D001795:Blood Pressure Determination; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003692:Delayed-Action Preparations / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy*; D017275:Isradipine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011336:Probability; D018570:Risk Assessment; D012720:Severity of Illness Index; D016037:Single-Blind Method; D016896:Treatment Outcome
chemical_list: D002121:Calcium Channel Blockers; D003692:Delayed-Action Preparations; D017311:Amlodipine; D017275:Isradipine