title: Coronary artery disease: myocardial perfusion MR imaging with sensitivity encoding versus conventional angiography.
abstract: OBJECTIVE
  To evaluate the technical performance of sensitivity encoding (SENSE)-accelerated myocardial perfusion magnetic resonance (MR) imaging and prospectively assess the diagnostic accuracy of this examination for depiction of significant coronary artery disease (CAD).
  
  
  METHODS
  All 102 subjects provided written informed consent, and the local ethics committee approved the study. A saturation-recovery segmented k-space gradient-echo pulse sequence was combined with SENSE to allow dynamic acquisition of myocardial perfusion data on four parallel short-axis MR image sections at every heartbeat. This technique was evaluated in 10 healthy volunteers and in 92 patients scheduled to undergo conventional coronary angiography. Gadopentetate dimeglumine was peripherally injected at rest and during adenosine-induced stress. The maximal upslope of the signal intensity-time profiles was plotted for 16 myocardial segments defined on three MR image sections, and a myocardial perfusion reserve index (MPRI) between stress and rest, normalized to the input function from the blood pool of the most basal section, was calculated. Areas under receiver operating characteristic curves (AUCs) were used to assess the diagnostic performance of cardiac MR imaging for depiction of greater than 70% CAD seen at coronary angiography, the reference standard.
  
  
  RESULTS
  In volunteers, the mean myocardial enhancement was 2.1 +/- 1.2 (standard deviation), with homogeneous signal intensity distribution across the segments. The diagnostic accuracy of MPRI measurements was high (AUC, 0.908; sensitivity, 88% [52 of 59 patients]; specificity, 82% [27 of 33 patients]). Diagnostic performance was similar among separate analyses of the three coronary territories and among separate analyses of data in the patients with diabetes mellitus, left ventricular hypertrophy, or myocardial infarction.
  
  
  CONCLUSIONS
  Multisection myocardial perfusion MR imaging with SENSE is feasible and has high diagnostic accuracy in the detection of CAD.
authors.affiliation: BHF Cardiac Magnetic Resonance Unit and Department of Medical Physics, the General Infirmary at Leeds, Room 170, D-floor, Jubilee Building, Great George St, Leeds LS1 3EX, England, UK. sven.plein@leedsth.nhs.uk
authors.forename: Sven
authors.initials: S
authors.lastname: Plein
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Radjenovic
authors.forename: John P
authors.initials: JP
authors.lastname: Ridgway
authors.forename: David
authors.initials: D
authors.lastname: Barmby
authors.forename: John P
authors.initials: JP
authors.lastname: Greenwood
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Ball
authors.forename: Mohan U
authors.initials: MU
authors.lastname: Sivananthan
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis*; D023921:Coronary Stenosis / Q000175:diagnosis; D005080:Exercise Test; D005240:Feasibility Studies; D005260:Female; D019786:Gadolinium DTPA; D015637:Gated Blood-Pool Imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis; D017202:Myocardial Ischemia / Q000175:diagnosis*; D011237:Predictive Value of Tests; D012372:ROC Curve; D012016:Reference Values; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D013673:Technology Assessment, Biomedical
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA