Lipoprotein(a) levels in patients with unstable angina and their relationship with atherothrombosis and myocardial damage.
The aim of the study was to compare lipoprotein(a) [Lp(a)] levels in patients with cTroponin-I (cTn-I)-positive or -negative unstable angina and to investigate their relationship with atherothrombosis. A total of 202 consecutive patients were enrolled in the study. Lp(a), fibrinogen, plasminogen, PAI-1 and t-PA levels were measured and C-reactive protein (CRP) assays were performed on admission for all patients, and venous blood samples were drawn 12 and 24 h later for cTn-I measurements. The patients were divided into cTn-I-negative (cTn-I < 1 ng/ml) and -positive (cTn-I > or = 1 ng/ml) unstable angina groups. Lp(a) levels of the cTn-I-positive patients were higher than those of the cTn-I-negative patients (52.9 +/- 6.0 and 15.7 +/- 2.5 mg/dl, p < 0.0001). There was a positive correlation between Lp(a) and cTn-I levels (r = 0.692; p = 0.0001). Increase in coagulation activity and impairment in fibrinolytic activity were significant in the cTn-I-positive patients. Elevated Lp(a) levels may have a role in the development of myocardial damage in patients with unstable angina.
Yazici
M
M
Department of Cardiology, Ondokuz Mayis University, School of Medicine, Samsun, Turkey. drmeyaz@hotmail.com
Demircan
S
S
Durna
K
K
Sahin
M
M
D000789:Angina, Unstable / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood*; D003328:Coronary Thrombosis / Q000097:blood*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D017270:Lipoprotein(a) / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D010958:Plasminogen / Q000378:metabolism; D011237:Predictive Value of Tests; D012307:Risk Factors; D019210:Troponin I / Q000097:blood*
D017270:Lipoprotein(a); D019210:Troponin I; D005340:Fibrinogen; D010958:Plasminogen