The concentration of apolipoprotein A-I decreases during experimentally induced acute-phase processes in pigs.
In this work, apolipoprotein A-I (ApoA-I) was purified from pig sera. The responses of this protein after sterile inflammation and in animals infected with Actinobacillus pleuropneumoniae or Streptococcus suis were investigated. Decreases in the concentrations of ApoA-I, two to five times lower than the initial values, were observed at 2 to 4 days. It is concluded that ApoA-I is a negative acute-phase protein in pigs.
Carpintero
R
R
Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, 50009 Zaragoza, Spain.
Piñeiro
M
M
Andrés
M
M
Iturralde
M
M
Alava
M A
MA
Heegaard
P M H
PM
Jobert
J L
JL
Madec
F
F
Lampreave
F
F
D000189:Actinobacillus Infections / Q000276:immunology* / Q000382:microbiology / Q000503:physiopathology; D016977:Actinobacillus pleuropneumoniae / Q000472:pathogenicity; D000595:Amino Acid Sequence; D000818:Animals; D016632:Apolipoprotein A-I / Q000097:blood* / Q000737:chemistry; D007249:Inflammation / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology; D008969:Molecular Sequence Data; D013290:Streptococcal Infections / Q000276:immunology* / Q000382:microbiology / Q000503:physiopathology; D017011:Streptococcus suis / Q000472:pathogenicity; D013552:Swine; D013553:Swine Diseases / Q000276:immunology* / Q000382:microbiology* / Q000503:physiopathology; D014425:Turpentine
D016632:Apolipoprotein A-I; D014425:Turpentine