title: Pharmacokinetics of tenofovir in breast milk of lactating rhesus macaques.
abstract: To study tenofovir transfer into milk, two lactating macaques were given a subcutaneous dose of tenofovir (30 mg/kg of body weight). Peak concentrations and area under the curve values of tenofovir in milk were approximately 3 and approximately 20% of those detected in serum, respectively.
authors.affiliation: California National Primate Research Center, University of California, Davis, CA 95616, USA. kkvanrompay@ucdavis.edu
authors.forename: Koen K A
authors.initials: KK
authors.lastname: Van Rompay
authors.forename: Marta
authors.initials: M
authors.lastname: Hamilton
authors.forename: Brian
authors.initials: B
authors.lastname: Kearney
authors.forename: Norbert
authors.initials: N
authors.lastname: Bischofberger
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D019380:Anti-HIV Agents / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D005260:Female; D006207:Half-Life; D008253:Macaca mulatta; D008892:Milk / Q000737:chemistry / Q000378:metabolism*; D063065:Organophosphonates / Q000097:blood / Q000493:pharmacokinetics*; D010865:Pilot Projects; D000068698:Tenofovir
chemical_list: D019380:Anti-HIV Agents; D063065:Organophosphonates; D000068698:Tenofovir; D000225:Adenine