title: [Efficacy of therapeutic and prophylactic actions of ultralow doses of antibodies to gamma-interferon in experimental murine model of herpes virus].
abstract: The process of the disease due to herpes simplex virus types 1 and 2 (HSV-1 and 2) was studied on white uninbred mice weighing 10 to 12 g. The animals were infected intracerebrally or intraperitoneally. Intraperitoneal contamination of the animals with MS strain of HSV-2 was used for the experimental model of the herpes simplex infection. The prophylactic antiherpes action of ultralow doses of the human gamma-interferon antibodies (ULD of anti-IFN-gamma) at a course of its intragastral administration was evaluated. The preparation was shown to have a significant (p < 0.05) protective effect in a dose of 10 LD50, evident from a 10-fold decrease of the HSV-2 accumulation in the brain, a lower percentage of the animal deaths and an increase of the average lifespan of the animals by 3.3 days. The study of the therapeutic action of ULD of anti-IFN-gamma at a course of its intragastral administration showed that the preparation had no significant positive effect on the disease process in the animals infected with HSV-2 in a dose of 10 LD50. However, a positive effect associated with delayed virus replication in the brain was observed in the study on the therapeutic effect of ULD of anti-IFN-gamma after its intragastral administration to the mice infected with a sublethal dose of the virus.
authors.forename: M A
authors.initials: MA
authors.lastname: Susloparov
authors.forename: N M
authors.initials: NM
authors.lastname: Makhova
authors.forename: N V
authors.initials: NV
authors.lastname: Noskova
authors.forename: I V
authors.initials: IV
authors.lastname: Pliasunov
authors.forename: I M
authors.initials: IM
authors.lastname: Susloparov
authors.forename: A N
authors.initials: AN
authors.lastname: Sergeev
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Sherstoboev
authors.forename: A V
authors.initials: AV
authors.lastname: Martiushev-Poklad
authors.forename: S A
authors.initials: SA
authors.lastname: Sergeeva
authors.forename: O I
authors.initials: OI
authors.lastname: Epshteĭn
authors.forename: A G
authors.initials: AG
authors.lastname: Glotov
authors.forename: T I
authors.initials: TI
authors.lastname: Glotova
mesh_terms: D000818:Animals; D000906:Antibodies / Q000008:administration & dosage* / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D006561:Herpes Simplex / Q000188:drug therapy*; D018259:Herpesvirus 1, Human; D018258:Herpesvirus 2, Human; D007371:Interferon-gamma / Q000276:immunology; D008297:Male; D051379:Mice; D011817:Rabbits; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000906:Antibodies; D007371:Interferon-gamma