title: Osteoclastic function is accelerated in male patients with type 2 diabetes mellitus: the preventive role of osteoclastogenesis inhibitory factor/osteoprotegerin (OCIF/OPG) on the decrease of bone mineral density.
abstract: To clarify the pathogenesis of altered bone metabolism in diabetic state and its underlying mechanisms, the bone mineral content and fasting levels of serum intact parathyroid hormone (i-PTH), intact osteocalcin (i-OC), tartrate-resistant acid phosphatase (TRAP) and osteoclastgenesis inhibitory factor/osteoprotegerin (OCIF/OPG) were measured in male type 2 diabetic patients and their age-matched controls. In addition, urine levels of osteoclastic markers, C-telopeptide of type I collagen (CTx), deoxypyridinoline (DPD), and N-telopeptide of type I collagen (NTx) were simultaneously determined. Serum levels of i-PTH and i-OC in diabetic patients were significantly lower than those in the controls. Conversely, serum concentrations of TRAP were significantly elevated in diabetic patients. However, no clear correlation was observed between serum i-OC and TRAP. It was also observed that urinary excretion of CTx, DPD, and NTx was significantly increased in the diabetics as compared with the controls. Unexpectedly, serum levels of OCIF/OPG tended to be higher in the diabetic group, and these values exhibited a significantly positive correlation with those of serum TRAP. There was found a significantly negative correlation between serum TRAP and bone mineral density (BMD) and also between serum OCIF/OPG and bone mineral density. It seems probable that OCIF/OPG has a suppressive role on the increased bone resorption to prevent further loss of the skeletal bone mass in type 2 diabetic patients.
authors.affiliation: Third Department of Internal Medicine, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Suzuki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kurose
authors.forename: Makoto
authors.initials: M
authors.lastname: Takizawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Maruyama
authors.forename: Kenji
authors.initials: K
authors.lastname: Ushikawa
authors.forename: Munetsugu
authors.initials: M
authors.lastname: Kikuyama
authors.forename: Chieko
authors.initials: C
authors.lastname: Sugimoto
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Seino
authors.forename: Shinya
authors.initials: S
authors.lastname: Nagamatsu
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ishida
mesh_terms: D000135:Acid Phosphatase / Q000097:blood; D000596:Amino Acids / Q000652:urine; D015415:Biomarkers / Q000097:blood; D015519:Bone Density / Q000187:drug effects*; D002096:C-Peptide / Q000737:chemistry / Q000652:urine; D002117:Calcitriol / Q000097:blood; D002118:Calcium / Q000097:blood; D003094:Collagen / Q000652:urine; D024042:Collagen Type I; D003627:Data Interpretation, Statistical; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology* / Q000652:urine; D006023:Glycoproteins / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology* / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000097:blood; D007527:Isoenzymes / Q000097:blood; D008274:Magnesium / Q000097:blood; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D010010:Osteoclasts / Q000502:physiology*; D053244:Osteoprotegerin; D010281:Parathyroid Hormone / Q000097:blood; D010455:Peptides / Q000652:urine; D010758:Phosphorus / Q000097:blood; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D018124:Receptors, Tumor Necrosis Factor / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D012737:Sex Factors; D000071681:Tartrate-Resistant Acid Phosphatase
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D002096:C-Peptide; D024042:Collagen Type I; D006023:Glycoproteins; D007328:Insulin; D007527:Isoenzymes; D053244:Osteoprotegerin; D010281:Parathyroid Hormone; D010455:Peptides; D018160:Receptors, Cytoplasmic and Nuclear; D018124:Receptors, Tumor Necrosis Factor; C506030:TNFRSF11B protein, human; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D010758:Phosphorus; C036020:deoxypyridinoline; D003094:Collagen; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase; D002117:Calcitriol; D008274:Magnesium; D002118:Calcium