Follow-up of cytologic predictions of endocervical glandular abnormalities: histologic outcomes in 123 cases.
OBJECTIVE
To determine histologic positive predictive values (PPVs) for three categories of cytologic reports of endocervical glandular abnormalities.


METHODS
We obtained histologic follow-up for 100% of 67 cytologic predictions of adenocarcinoma in situ (AIS) and 82% of 39 predictions of possible AIS (?AIS) made over a 4-year period (1999-2002) and for 25% of 105 atypical endocervical cells (AEC) predictions over a 12-month period (2000). For each category of cytologic report, we determined the histologic yields of high-grade lesions overall and of high-grade glandular lesions.


RESULTS
PPVs for predictions of AIS and ?AIS for high-grade lesions overall were 91% and 75% (p = .032), respectively, and those for high-grade glandular lesions were 88% and 72% (p = .046), respectively. For a cytologic report of AEC, of those with histologic follow-up, 9% had a high-grade lesion and 7% had a high-grade glandular lesion.


CONCLUSIONS
Cytology can accurately predict AIS.
Roberts
Jennifer M
JM
Mayne Health Laverty Pathology, Sydney, New South Wales, Australia. jennifer.roberts@maynegroup.com
Thurloe
Julia K
JK
Biro
Clare
C
Hyne
Suzanne G
SG
Williams
Katherine E
KE
Bowditch
Ron C
RC
D000230:Adenocarcinoma / Q000175:diagnosis*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000175:diagnosis*; D002584:Cervix Uteri / Q000473:pathology; D003581:Cytodiagnosis / Q000379:methods / Q000592:standards; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis*; D014626:Vaginal Smears