title: Thermally gated liposomes.
abstract: The combined use of a pore-forming amphiphile, 1 (derived from lysine, cholic acid, and spermine), and thermally sensitive liposomes (made from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, DPPC) to create "thermally gated liposomes" (TGLs) has been demonstrated. Thus, at temperatures that lie above the gel to liquid-crystalline phase transition temperature of DPPC (i.e., 41 degrees C), 1 creates pores within DPPC membranes through which entrapped aqueous solutes, such as carboxyfluorescein, can readily pass. Below this temperature, efflux rates are greatly reduced. The potential of TGLs as devices for the targeted delivery of therapeutic agents is briefly discussed.
authors.affiliation: Department of Chemistry, Lehigh University, Bethlehem, PA 18015, USA.
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Chen
authors.forename: Steven L
authors.initials: SL
authors.lastname: Regen
mesh_terms: D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry*; D016503:Drug Delivery Systems; D005452:Fluoresceins / Q000737:chemistry*; D007700:Kinetics; D008051:Lipid Bilayers / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry*; D010713:Phosphatidylcholines / Q000737:chemistry; D013096:Spermine / Q000031:analogs & derivatives / Q000737:chemistry; D013696:Temperature
chemical_list: D005452:Fluoresceins; D008051:Lipid Bilayers; D008081:Liposomes; D010713:Phosphatidylcholines; D015060:1,2-Dipalmitoylphosphatidylcholine; D013096:Spermine; C024098:6-carboxyfluorescein; C028694:1-palmitoyl-2-oleoylphosphatidylcholine