Genetics and bioinformatics of primary open angle glaucoma: an Indian perspective.
Glaucoma is the second largest blinding disorder, after cataract, affecting about 67 million people worldwide. In India about 1.5 million people are blind due to glaucoma. Primary open angle glaucoma is the major sub-type of glaucoma affecting all ages and is genetically complex. Myocilin and optineurin are two different genes that have been implicated for primary open angle glaucoma. This review is focused on the studies being conducted in India on primary open angle glaucoma to identify the molecular defects and new directions undertaken using bioinformatic approaches towards a better understanding of the disease.
Ray
Kunal
K
Human Genetics and Genomics Division, Indian Institute of Chemical Biology, Kolkata 700 032.
Thakur
Sanjay Kumar Daulat
SK
Banerjee
Arun Kumar
AK
Mukhopadhyay
Arijit
A
Acharya
Moulinath
M
Bhattacharjee
Ashima
A
Sen
Abhijit
A
Bhaduri
Gautam
G
D001766:Blindness / Q000209:etiology / Q000235:genetics; D018797:Cell Cycle Proteins; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D019295:Computational Biology; D003598:Cytoskeletal Proteins / Q000235:genetics; D005136:Eye Proteins / Q000235:genetics; D005902:Glaucoma, Open-Angle / Q000145:classification / Q000150:complications / Q000235:genetics*; D006023:Glycoproteins / Q000235:genetics; D006801:Humans; D007194:India; D026901:Membrane Transport Proteins; D035582:Transcription Factor TFIIIA / Q000235:genetics; D014786:Vision Disorders / Q000209:etiology* / Q000235:genetics; D000099179:Myocilin
D018797:Cell Cycle Proteins; D003598:Cytoskeletal Proteins; D005136:Eye Proteins; D006023:Glycoproteins; D026901:Membrane Transport Proteins; D035582:Transcription Factor TFIIIA; D000099179:Myocilin; C409460:OPTN protein, human