title: Relationship between lung function and physical performance in disabled older women.
abstract: BACKGROUND
  Understanding the association between lung function and physical performance in disabled older women helps in determining the potential for prevention and treatment strategies to decrease disability. The aim of this study was to determine the association of lung function with objective and self-reported physical performance in community-dwelling disabled older women.
  
  
  METHODS
  The Women's Health and Aging Study I consists of 1002 disabled community-dwelling women aged > or = 65. Of these women, 840 underwent spirometry with determination of forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). Cross-sectional analyses included multivariate linear regression to assess the association between FEV1, FVC, FEV1/FVC, and the time to walk four meters after adjusting for confounders, including age, race, geriatric depression scale score, body mass index, muscle strength, osteoarthritis, smoking status, and cardiovascular disease. Multiple logistic regression was used to assess the association between FEV1, FVC, FEV1/FVC, and self-reported disability in physical performance.
  
  
  RESULTS
  FEV1 was independently associated with time to walk 4 meters. For every 100 ml decrease in FEV1, there was a 0.15-second (95% confidence interval: 0.24 to 0.06) increase in time to walk 4 meters. There was an 8% increase in the prevalent odds of self-reported disability in physical performance for every 100 ml decrease in FEV1. FVC was also associated with physical performance measures. In contrast, FEV1/FVC was associated with objective but not subjective physical performance.
  
  
  CONCLUSIONS
  Decreasing lung function is independently associated with decrements in objective and self-reported physical performance in disabled older women.
authors.affiliation: MHS, Center on Aging and Health and Division of Geriatric Medicine, The Johns Hopkins School of Medicne, Baltimore, Maryland 21205, USA. cfsimpson@jhmi.edu
authors.forename: Crystal F
authors.initials: CF
authors.lastname: Simpson
authors.forename: Naresh M
authors.initials: NM
authors.lastname: Punjabi
authors.forename: Linda
authors.initials: L
authors.lastname: Wolfenden
authors.forename: Michelle
authors.initials: M
authors.lastname: Shardell
authors.forename: David M
authors.initials: DM
authors.lastname: Shade
authors.forename: Linda P
authors.initials: LP
authors.lastname: Fried
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D003430:Cross-Sectional Studies; D006233:Persons with Disabilities; D005260:Female; D005541:Forced Expiratory Volume; D015577:Geriatric Assessment; D006801:Humans; D016014:Linear Models; D015999:Multivariate Analysis; D010807:Physical Endurance / Q000502:physiology*; D010809:Physical Fitness / Q000502:physiology; D011336:Probability; D011379:Prognosis; D012042:Registries; D012129:Respiratory Function Tests; D012143:Respiratory Physiological Phenomena; D018570:Risk Assessment; D013147:Spirometry; D014797:Vital Capacity