Interrelationship between polymorphisms of incA, fusogenic properties of Chlamydia trachomatis strains, and clinical manifestations in patients in The Netherlands.
IncA variation among Dutch Chlamydia trachomatis isolates was investigated. Of 98 strains, two carried an incA with a premature stop codon, lacked IncA, and were nonfusogenic, while 96 contained an intact incA, expressed IncA, and were fusogenic. Among these 96 strains, nine IncA sequence types were found, of which the three most frequently encountered (88% of the strains) were randomly distributed among symptomatic and asymptomatic patients.
Pannekoek
Yvonne
Y
Dept. of Medical Microbiology, Academic Medical Center, University of Amsterdam, Room L1-115, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands. y.pannekoek@amc.uva.nl.
Spaargaren
Joke
J
Langerak
Ankie A J
AA
Merks
Judith
J
Morré
Servaas A
SA
van der Ende
Arie
A
D001426:Bacterial Proteins / Q000235:genetics*; D002690:Chlamydia Infections / Q000503:physiopathology*; D002692:Chlamydia trachomatis / Q000235:genetics* / Q000302:isolation & purification; D014644:Genetic Variation; D006801:Humans; D009426:Netherlands; D010750:Phosphoproteins / Q000235:genetics*; D011110:Polymorphism, Genetic
D001426:Bacterial Proteins; C094163:IncA protein, bacteria; D010750:Phosphoproteins