Live delivery following transfer of a single frozen-thawed embryo derived from a 42-year-old woman with marked decreased oocyte reserve.
OBJECTIVE
To determine if live birth is possible in a woman of older reproductive age and who has markedly decreased oocyte reserve following frozen embryo transfer of an oocyte fertilized by intracytoplasmic sperm injection of testicular sperm.


METHODS
Ethinyl estradiol followed by ovarian stimulation with gonadotropins was used and a mature follicle was attained. Following oocyte retrieval 34 hours later, intracytoplasmic sperm injection of testicular sperm was performed. The embryo was cryopreserved.


RESULTS
A live delivery of a full-term baby ensued. Following subsequent frozen embryo transfer, the baby was diagnosed with Down's syndrome and subsequently died.


CONCLUSIONS
This is the first report of a live delivery following frozen embryo transfer in a woman of advanced reproductive age with marked decreased oocyte reserve.
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J H
JH
The University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, USA.
D000328:Adult; D015925:Cryopreservation; D004314:Down Syndrome / Q000175:diagnosis; D004624:Embryo Transfer; D004967:Estrogens / Q000627:therapeutic use; D004997:Ethinyl Estradiol / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use; D043373:Follicle Stimulating Hormone, Human / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D008423:Maternal Age; D009865:Oocytes; D009930:Organic Chemicals; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome; D020554:Sperm Injections, Intracytoplasmic
D004967:Estrogens; D005300:Fertility Agents, Female; D043373:Follicle Stimulating Hormone, Human; D009930:Organic Chemicals; C432248:Repronex; D004997:Ethinyl Estradiol