title: Anal melanoma in the era of sentinel lymph node mapping: a diagnostic and therapeutic challenge.
abstract: Melanoma of the anal canal is a rare malignancy that often has an atypical presentation. Locoregional metastases, which are often present at the initial presentation, may occur in both groin and pelvic lymph nodes, but the utility of lymph node dissection remains unknown. We explored the possibility of applying the technique of sentinel lymph node (SLN) mapping to anal melanoma. SLN mapping was performed in 2 patients with anal melanoma. Radioactive tracer and blue dye were injected around the lesions. The SLN was identified pre-operatively by lymphoscintigraphy, and at surgery with a hand-held gamma detector and by visualization of the dye. The SLN was identified in both patients, only in the groin in one and only in the presacral region in the other. One patient had a wide local excision of the anal lesion with house flap anoplasty, while the other had abdominoperineal resection with total mesorectal excision. There were no SLN metastases in either patient. The technique of SLN mapping and biopsy is easily adapted to surgery for malignant melanoma of the anus. SLN mapping and biopsy could aid in planning surgical strategy, but definitive conclusions may only be reached after more experience has been acquired.
authors.affiliation: Department of Surgery, Shaare Zedek Medical Center, Ben-Gurion University, Jerusalem 91031, Israel.
authors.forename: O
authors.initials: O
authors.lastname: Olsha
authors.forename: A
authors.initials: A
authors.lastname: Mintz
authors.forename: Z
authors.initials: Z
authors.lastname: Gimon
authors.forename: R
authors.initials: R
authors.lastname: Gold Deutch
authors.forename: I
authors.initials: I
authors.lastname: Rabin
authors.forename: A
authors.initials: A
authors.lastname: Halevy
authors.forename: P
authors.initials: P
authors.lastname: Reissman
mesh_terms: D001005:Anus Neoplasms / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging; D008545:Melanoma / Q000175:diagnosis* / Q000601:surgery; D008875:Middle Aged; D011877:Radionuclide Imaging; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*