[Synthesis and antibacterial activity of ciprofloxacin derivatives].
OBJECTIVE
To study the synthesis and antibacterial activity of ciprofloxacin derivatives.


METHODS
Ciprofloxacin derivatives were synthesized primarily from 2-methyl-5-nitroimidazol and ciprofloxacin through nucleophilic substitution. The antibacterial activity of the synthesized compounds were tested.


RESULTS
Nine new compounds were synthesized. The structure of the title compounds were confirmed by 1H NMR, MS and element analysis.


CONCLUSIONS
Compounds II, IVC and IVD showed appreciable antibacterial activity, and were worth further studying.
Ye
Fa-qing
FQ
Department of Medicinal Chemistry, Wenzhou Medical College, Wenzhou 325035, China. yfq@wzmc.net
Ding
You-mei
YM
Chen
Li
L
Ye
Song
S
Chen
Zhi-xiang
ZX
D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D051379:Mice; D015394:Molecular Structure; D009593:Nitroimidazoles
D000890:Anti-Infective Agents; D009593:Nitroimidazoles; C052586:2-methyl-5-nitroimidazole; D002939:Ciprofloxacin