title: [Application to allergic diseases].
abstract: The increasing prevalence of allergic diseases in developed countries is considered to be caused, at least in part, by rapid improvement of human hygiene. In human beings, the immune system developed as an ingenious device for defending against frequent attacks by microbes. Therefore, our immune system seems to have become deranged in our recent, unprecedentedly hygienic environment. It is now necessary to understand the total functional elements comprising the immune system, not just a single molecule present in an immunocyte working in our immune system. Microarray analysis is now becoming capable of detecting the whole transcripts present in a cell. It is anticipated that we can understand the deranged human immunity using the system biology. It is also expected to predict previously unexpected drug-related adverse events caused by interaction of a drug with responsible molecules present in vital organs.
authors.affiliation: Department of Allergy & Immunology, National Research Institute for Child Health & Development.
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Saito
mesh_terms: D000818:Animals; D016207:Cytokines / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics / Q000276:immunology* / Q000517:prevention & control; D046228:Microarray Analysis; D020411:Oligonucleotide Array Sequence Analysis; D049490:Systems Biology
chemical_list: D016207:Cytokines