Adaptor usage and Toll-like receptor signaling specificity.
It is now well established that Toll-like receptors (TLRs) act as primary sensors of microbial compounds. Details of the molecular mechanisms governing TLR responses are emerging steadily and our understanding of the signaling pathways activated these receptors has improved greatly over the last few years. Differences in adaptor usage, cellular localisation and signaling cascades have been elucidated. In this review we will summarize the current understanding of TLR signaling and its regulation.
Dunne
Aisling
A
Department of Biochemistry, Trinity College Dublin, Dublin 2, Ireland. aidunne@tcd.ie
O'Neill
Luke A J
LA
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D008562:Membrane Glycoproteins / Q000145:classification / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000145:classification / Q000378:metabolism*; D015398:Signal Transduction; D013379:Substrate Specificity; D051193:Toll-Like Receptors
D048868:Adaptor Proteins, Signal Transducing; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors