title: Synthesis of carbamate-linked lipids for gene delivery.
abstract: Series of lipids 1a-d and 2a,b, with carbamate linkages between hydrocarbon chains and ammonium or tertiary amine head, which were pH sensitive, were synthesized for liposome-mediated gene delivery. The variable length of carbon chains and quaternary ammonium or neutral tertiary amine heads allowed to find the structure-function relationship of how these factors affect cationic lipids on gene delivery performance.
authors.affiliation: State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China. dut-liu@163.com
authors.forename: Dongliang
authors.initials: D
authors.lastname: Liu
authors.forename: Jianjun
authors.initials: J
authors.lastname: Hu
authors.forename: Weihong
authors.initials: W
authors.lastname: Qiao
authors.forename: Zongshi
authors.initials: Z
authors.lastname: Li
authors.forename: Shubiao
authors.initials: S
authors.lastname: Zhang
authors.forename: Lvbo
authors.initials: L
authors.lastname: Cheng
mesh_terms: D002219:Carbamates / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D004337:Drug Carriers; D015316:Genetic Therapy; D050356:Lipid Metabolism; D008055:Lipids / Q000138:chemical synthesis*; D008081:Liposomes / Q000737:chemistry*
chemical_list: D002219:Carbamates; D004337:Drug Carriers; D008055:Lipids; D008081:Liposomes