Transplantation of single pediatric kidneys into adult recipients.
OBJECTIVE
To evaluate the outcome of single pediatric kidneys transplanted into adult recipients.


METHODS
A retrospective single-center review was performed of transplants from donors less than 5 years of age. Outcomes were compared with recipients of grafts from donors 18 to 45 years transplanted during the same time period.


RESULTS
Thirty single renal transplants from pediatric donors and 117 transplants from adult donors between 18 and 45 years of age were performed during the study period. The mean age of the pediatric donors was 2.9 +/- 0.8 years versus 31.5 +/- 8.9 years for adult donors (P < .001). The mean age of the recipients of pediatric donors was 41.9 +/- 13 years versus 48 +/- 12.6 years for recipients of adult grafts (P = .020). The mean recipient weight of pediatric donors was 55.9 +/- 7.8 kg versus 78.0 +/- 17.7 kg for recipients of adult donors (P < .001). Sixty-six percent of pediatric donor recipients were of female gender compared to only 36% of adult donor recipients (P = .005). Death-censored actuarial graft survivals at 1 and 4 years for recipients of pediatric donor grafts were 90% and 85% compared to 93% and 85% for recipients of adult donor grafts (P = NS). The mean calculated creatinine clearances of adult donor graft recipients at 1 and 4 years posttransplantation were 70.8 +/- 26.5 and 73.7 +/- 27.2 mL/min, respectively, compared to 50.3 +/- 20.1 and 56.3 +/- 21.4 mL/min for pediatric donor grafts (P < .01 at 1 and 4 years).


CONCLUSIONS
The use of single pediatric donor kidneys provides an excellent opportunity to safely expand the donor pool.
Csapo
Z
Z
Division of Immunology and Organ Transplantation, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
Knight
R J
RJ
Podder
H
H
Kerman
R H
RH
Schoenberg
L
L
Katz
S M
SM
Van Buren
C T
CT
Kahan
B D
BD
D000206:Actuarial Analysis; D000328:Adult; D002675:Child, Preschool; D006084:Graft Rejection / Q000453:epidemiology; D006085:Graft Survival / Q000502:physiology; D006801:Humans; D016030:Kidney Transplantation / Q000401:mortality / Q000502:physiology*; D012189:Retrospective Studies; D013997:Time Factors; D014019:Tissue Donors / Q000706:statistics & numerical data*; D017211:Treatment Failure