title: Early postnatal changes in the perfusion index in term newborns with subclinical chorioamnionitis.
abstract: BACKGROUND
  Chorioamnionitis (HCA) in term newborns is often subclinical and associated with neonatal morbidity and mortality.
  
  
  OBJECTIVE
  To assess the value of the pulse oximetry perfusion index (PI) in the early prediction of subclinical HCA in term newborns.
  
  
  METHODS
  PI cut-off values were first identified in 51 term newborns with HCA and 115 matched controls, retrospectively categorised on the basis of placental histology (study phase 1). The PI thresholds obtained were subsequently tested on an unselected case series of 329 prospectively recruited, term newborns (study phase 2). PI was evaluated during the first five minutes after delivery. Initial illness severity and short term clinical outcomes were determined.
  
  
  RESULTS
  In study phase 1, newborns with HCA had lower PI one and five minutes (p<0.0001) after delivery, lower one minute Apgar score (p = 0.017), lower cord blood base excess (p = 0.0001), together with higher rates of admission to neonatal intensive care unit (p = 0.0001) and endotracheal intubation (p = 0.017), and higher SNAP-PE (p<0.0001) and NTISS (p<0.0001) scores than those without HCA. In the prospective validation phase of the study, the PI cut-off values generated (one minute < or =1.74, five minutes < or =2.18) showed 100% sensitivity, 99.4% specificity, 93.7% positive predictive value, and 100% negative predictive value in identifying subclinical HCA. Early identification of HCA was associated with a decreased rate of admission to intensive care (p = 0.012), as well as lower initial illness severity (p< or =0.0001) and therapeutic intensity (p = 0.0006) than the newborns with HCA in phase 1.
  
  
  CONCLUSIONS
  These findings suggest that early PI monitoring is helpful in identifying HCA in term newborns.
authors.affiliation: Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Siena, Italy.
authors.forename: C
authors.initials: C
authors.lastname: De Felice
authors.forename: A
authors.initials: A
authors.lastname: Del Vecchio
authors.forename: M
authors.initials: M
authors.lastname: Criscuolo
authors.forename: A
authors.initials: A
authors.lastname: Lozupone
authors.forename: S
authors.initials: S
authors.lastname: Parrini
authors.forename: G
authors.initials: G
authors.lastname: Latini
mesh_terms: D001034:Apgar Score; D001831:Body Temperature; D002821:Chorioamnionitis / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005528:Foot / Q000098:blood supply; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010092:Oximetry / Q000379:methods; D011247:Pregnancy; D011446:Prospective Studies; D012039:Regional Blood Flow; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index