title: The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery.
abstract: The human checkpoint sensor and alternative clamp Rad9-Rad1-Hus1 can interact with and specifically stimulate DNA ligase I. The very recently described interactions of Rad9-Rad1-Hus1 with MutY DNA glycosylase, DNA polymerase beta and Flap endonuclease 1 now complete our view that the long-patch base excision machinery is an important target of the Rad9-Rad1-Hus1 complex, thus enhancing the quality control of DNA.
authors.affiliation: Institute of Veterinary Biochemistry and Molecular Biology, University of Zürich-Irchel, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Smirnova
authors.forename: Magali
authors.initials: M
authors.lastname: Toueille
authors.forename: Enni
authors.initials: E
authors.lastname: Markkanen
authors.forename: Ulrich
authors.initials: U
authors.lastname: Hübscher
mesh_terms: D018797:Cell Cycle Proteins / Q000378:metabolism*; D004249:DNA Damage; D000072481:DNA Ligase ATP; D011088:DNA Ligases / Q000378:metabolism*; D004260:DNA Repair / Q000502:physiology*; D004789:Enzyme Activation; D005092:Exonucleases / Q000378:metabolism*; D006801:Humans; D046912:Multiprotein Complexes / Q000378:metabolism; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D011485:Protein Binding; D029702:Schizosaccharomyces pombe Proteins / Q000378:metabolism*
chemical_list: D018797:Cell Cycle Proteins; C000607892:LIG1 protein, human; D046912:Multiprotein Complexes; D018809:Proliferating Cell Nuclear Antigen; D029702:Schizosaccharomyces pombe Proteins; C106332:hus1 protein, S pombe; C069930:rad9 protein; D005092:Exonucleases; C113574:Rad1 protein, human; D011088:DNA Ligases; D000072481:DNA Ligase ATP