N-6 polyunsaturated fatty acids confer hemodynamic stability in an experimental model of multiple trauma.
Immunonutrition with diets enriched in polyunsaturated fatty acids (PUFAs) are becoming mandatory for multiple trauma patients. Solutions containing single n-6 PUFAs were administered intravenously in an experimental model of trauma. Thirty-five rabbits were studied; 13 controls; 10 administered gamma-linolenic acid (GLA) 30 min after fracture of the right femor; and 12 arachidonic acid (AA). Systolic, diastolic and mean arterial pressures and heart rate were recorded; serum levels of tumor necrosis factor-alpha (TNFalpha), malondialdehyde (MDA) and nitrate were estimated before and after therapy. Mean survival of controls, of animals treated with GLA and of animals treated with AA was 0.80, 1.41 and 3.60 days, respectively. Administration of PUFAs induced higher levels of blood pressure; that of AA decreased serum TNFalpha and tissue bacterial load compared to controls. Intravenous administration of n-6 PUFAs conferred hemodynamic stability and increased survival in a model of trauma rendering further research mandatory.
Efstathopoulos
Nicolas
N
2nd Department of Orthopaedics, University of Athens, Medical School, Greece.
Bathrellos
Efstathios
E
Giamarellos-Bourboulis
Evangelos J
EJ
Lazarettos
John
J
Papalois
Apostolos
A
Grecka
Paraskevi
P
Nikolaou
Vassilios
V
D000818:Animals; D016718:Arachidonic Acid / Q000008:administration & dosage / Q000378:metabolism*; D001424:Bacterial Infections; D001794:Blood Pressure / Q000502:physiology; D004042:Dietary Fats, Unsaturated; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics; D006801:Humans; D008315:Malondialdehyde / Q000097:blood; D009104:Multiple Trauma / Q000378:metabolism* / Q000628:therapy; D009566:Nitrates / Q000097:blood; D011817:Rabbits; D015996:Survival Rate; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D017965:gamma-Linolenic Acid / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use
D004042:Dietary Fats, Unsaturated; D009566:Nitrates; D014409:Tumor Necrosis Factor-alpha; D016718:Arachidonic Acid; D008315:Malondialdehyde; D017965:gamma-Linolenic Acid