title: Persistent serpentine supravenous hyperpigmented eruption associated with docetaxel.
abstract: Various mucocutaneous reactions have been reported with the use of systemic docetaxel. We describe a 47-year-old man who developed a persistent serpentine supravenous hyperpigmented eruption (PSSHE), beginning at the site of docetaxel injection and spreading along the superficial venous network in the anterior aspect of the right forearm and distal arm. The eruption occurred after the first infusion of docetaxel following insufficient venous washing. A second infusion was administered through a vein in the other forearm, but this time, abundant venous washing was performed and a similar eruption did not occur. To our knowledge, this is the second report of docetaxel-induced supravenous discoloration and we discussed the terminology and mechanism of this unique reaction.
authors.affiliation: Department of Dermatology, Abant Izzet Baysal University, Duzce Medical School, 81620 Konuralp, Duzce, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Aydogan
authors.forename: A
authors.initials: A
authors.lastname: Kavak
authors.forename: A H
authors.initials: AH
authors.lastname: Parlak
authors.forename: M
authors.initials: M
authors.lastname: Alper
authors.forename: A N
authors.initials: AN
authors.lastname: Annakkaya
authors.forename: M
authors.initials: M
authors.lastname: Erbas
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D001132:Arm; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D000077143:Docetaxel; D003875:Drug Eruptions / Q000473:pathology*; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced* / Q000473:pathology; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D043823:Taxoids / Q000009:adverse effects*; D014680:Veins
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D000077143:Docetaxel