title: Alkylation of natural endoperoxide G3-factor. Synthesis and antimalarial activity studies.
abstract: Alkylation of the peroxyhemiketal function is described and all synthesised endoperoxides show good antimalarial activity. New rearrangement reactions in the presence of CsCO3, and preliminary results on Fe(II) chemical reduction of the O-O bond are presented.
authors.affiliation: Laboratoire de Synthese et Physicochimie de Molecules d'Interet Biologique, UMR CNRS 5068, Universite Paul Sabatier, 118 route de Narbonne, 31062 Toulouse, France.
authors.forename: Fadia
authors.initials: F
authors.lastname: Najjar
authors.forename: Liliane
authors.initials: L
authors.lastname: Gorrichon
authors.forename: Michel
authors.initials: M
authors.lastname: Baltas
authors.forename: Christiane
authors.initials: C
authors.lastname: André-Barrès
authors.forename: Henri
authors.initials: H
authors.lastname: Vial
mesh_terms: D000478:Alkylation; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010545:Peroxides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects
chemical_list: D000962:Antimalarials; D010545:Peroxides