title: Synthesis and antiprotozoan evaluation of new alkyl-linked bis(2-thioxo-[1,3,5]thiadiazinan-3-yl) carboxylic acids.
abstract: Two new series of several alkyl-linked bis(2-thioxo-[1,3,5]thiadiazinan-3-yl) carboxylic acids were synthesized in a two step procedure from the corresponding alkyl bis-dithiocarbamic salt intermediary. The novel compounds were evaluated for their activity in vitro against Trypanosoma cruzi strain CL (clone CL B5) and Trichomonas vaginalis strain JH 31A.
authors.affiliation: Laboratorio de Síntesis Orgánica, Facultad de Química, Universidad de la Habana, 10400-Ciudad Habana, Cuba.
authors.forename: Julieta
authors.initials: J
authors.lastname: Coro
authors.forename: Rolando
authors.initials: R
authors.lastname: Pérez
authors.forename: Hortensia
authors.initials: H
authors.lastname: Rodríguez
authors.forename: Margarita
authors.initials: M
authors.lastname: Suárez
authors.forename: Celeste
authors.initials: C
authors.lastname: Vega
authors.forename: Miriam
authors.initials: M
authors.lastname: Rolón
authors.forename: David
authors.initials: D
authors.lastname: Montero
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Nogal
authors.forename: Alicia
authors.initials: A
authors.lastname: Gómez-Barrio
mesh_terms: D000818:Animals; D000994:Antitrichomonal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D013829:Thiadiazines / Q000138:chemical synthesis* / Q000494:pharmacology; D014246:Trichomonas vaginalis / Q000187:drug effects*; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D000994:Antitrichomonal Agents; D002264:Carboxylic Acids; D013829:Thiadiazines