Chitosan nanoparticles as a novel delivery system for ammonium glycyrrhizinate.
The ammonium glycyrrhizinate-loaded chitosan nanoparticles were prepared by ionic gelation of chitosan with tripolyphosphate anions (TPP). The particle size and zeta potential of nanoparticles were determined, respectively, by dynamic light scattering (DLS) and a zeta potential analyzer. The effects, including chitosan molecular weight, chitosan concentration, ammonium glycyrrhizinate concentration and polyethylene glycol (PEG) on the physicochemical properties of the nanoparticles were studied. These nanoparticles have ammonium glycyrrhizinate loading efficiency. The encapsulation efficiency decreased with the increase of ammonium glycyrrhizinate concentration and chitosan concentration. The introduction of PEG can decrease significantly the positive charge of particle surface. These studies showed that chitosan can complex TPP to form stable cationic nanoparticles for subsequent ammonium glycyrrhizinate loading.
Wu
Yan
Y
Key Laboratory of Molecular Engineering of Polymers of Educational Ministry, Department of Macromolecular Science, Fudan University, Shanghai 200433, People's Republic of China.
Yang
Wuli
W
Wang
Changchun
C
Hu
Jianhua
J
Fu
Shoukuan
S
D048271:Chitosan / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D004355:Drug Stability; D019695:Glycyrrhizic Acid / Q000008:administration & dosage*; D008970:Molecular Weight; D049329:Nanostructures; D009994:Osmolar Concentration; D011092:Polyethylene Glycols / Q000008:administration & dosage; D000644:Quaternary Ammonium Compounds / Q000008:administration & dosage; D017550:Spectroscopy, Fourier Transform Infrared
D000644:Quaternary Ammonium Compounds; D011092:Polyethylene Glycols; D019695:Glycyrrhizic Acid; D048271:Chitosan