[Expression of eotaxin gene in nasal mucosa of allergic rhinitis in the guinea pig sensitized by fungal allergen].
OBJECTIVE
To study the expression and significance of Eotaxin gene in nasal mucosa of guinea pig sensitized by fungal allergen.


METHODS
Alternaria alternata sensitized guinea pigs used as animal model of allergic rhinitis (AR). The changes in the nasal mucosa were studied by pathological method and the Eotaxin gene were studied by In Situ Hybridization.


RESULTS
The behavior science score of experimental group was significant higher than the controls group. Plenty eosinophils were found in lamina propria of nasal mucosa of experimental group. Eotaxin gene is expressed in lamina propria of nasal mucosa of experimental group. The controls group had not positive expression.


CONCLUSIONS
Eotaxin gene is expressed at high levels in nasal mucosa of fungal allergic rhinitis in the guinea pig. Plenty eosinophils were found in nasal mucosa. We considered that Eotaxin gene and eosinophils could play a key role in fungal allergic rhinitis.
Zhang
Zhiming
Z
Department of Otorhinolaryngology, First Hospital, China Medical University, Shenyang, 110003, China. zjk2002@tom.com
Sun
Shuyan
S
Wang
Shouchen
S
Ji
Wenyue
W
Guan
Chao
C
D000528:Alternaria; D000818:Animals; D000946:Antigens, Fungal; D054413:Chemokine CCL11; D019742:Chemokines, CC / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D006168:Guinea Pigs; D008297:Male; D009297:Nasal Mucosa / Q000473:pathology*; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology / Q000382:microbiology / Q000473:pathology*
D000946:Antigens, Fungal; D054413:Chemokine CCL11; D019742:Chemokines, CC