title: Expression of p8 protein in breast carcinoma; an inverse relationship with apoptosis.
abstract: BACKGROUND
  P8 is a transcription factor and its expression is elevated in response to apoptotic stimuli. However, p8 in human carcinoma tissue has not been investigated in depth. In this study, we investigated p8 expression in breast carcinoma.
  
  
  METHODS
  We immunohistochemically investigated p8 expression in 50 cases of breast carcinoma, including 7 non-invasive ductal carcinomas.
  
  
  RESULTS
  High expression of p8 was observed in 60% of cases, which was inversely related to tumor size and UICC stage. All non-invasive ductal carcinomas diffusely expressed p8. Furthermore, in tumors of 2 cm or larger, the p8 expression was inversely linked to the apoptotic index.
  
  
  CONCLUSIONS
  These results suggest that p8 plays a role in the early phase of breast carcinoma progression and especially in tumors of larger size, acting as an inhibitor of apoptosis of breast carcinoma cells.
authors.affiliation: Department of Surgery, Kuma Hospital, Kobe City, Japan. ito01@kuma-h.or.jp
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ito
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Motoo
authors.forename: Juan Lucio
authors.initials: JL
authors.lastname: Iovanna
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Kennichi
authors.initials: K
authors.lastname: Kakudo
authors.forename: Takashi
authors.initials: T
authors.lastname: Uruno
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Takamura
authors.forename: Akihiro
authors.initials: A
authors.lastname: Miya
authors.forename: Shinzaburo
authors.initials: S
authors.lastname: Noguchi
authors.forename: Kanji
authors.initials: K
authors.lastname: Kuma
authors.forename: Akira
authors.initials: A
authors.lastname: Miyauchi
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D051792:Basic Helix-Loop-Helix Proteins; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology*; D044584:Carcinoma, Ductal / Q000378:metabolism / Q000473:pathology; D018275:Carcinoma, Lobular / Q000378:metabolism / Q000473:pathology; D004268:DNA-Binding Proteins / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis*
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; C491643:NUPR1 protein, human