A rapid synthesis of 2-aryl-5-substituted-2,3-dihydrobenzofurans.
[reaction: see text] An effective strategy has been developed for the rapid and efficient one-pot synthesis of 2-aryl-5-substituted-2,3-dihydrobenzofurans from readily available o-nitrotoluenes and aromatic aldehydes. This strategy allows access to a structurally diverse array of products for further manipulation.
Kuethe
Jeffrey T
JT
Department of Process Research, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, USA. jeffrey_kuethe@merck.com
Wong
Audrey
A
Journet
Michel
M
Davies
Ian W
IW
D001572:Benzofurans / Q000138:chemical synthesis*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007202:Indicators and Reagents; D015394:Molecular Structure
D001572:Benzofurans; D007202:Indicators and Reagents