title: Expression of CD158b on peripheral blood lymphocytic cell after kidney transplantation.
abstract: OBJECTIVE
  To investigate the expression of CD158b on peripheral blood lymphocytes after kidney transplantation.
  
  
  METHODS
  Sixty two kidney transplant patients were divided into two groups (normal group and rejection group) according to pathologic results and clinical situation. Blood samples were assessed for percentage of CD3+; CD19+; CD3-CD16/56+; CD3+CD158b+; CD19+CD158b+, and CD3-CD16/56+CD158b+ subsets.
  
  
  RESULTS
  The percentages of CD3+ cells preop as well as at 1 and 7 postoperative and the day acute rejection happened were 60.06 +/- 4.67, 40.43 +/- 4.11, 31.67 +/- 4.04, and 39.21 +/- 5.20, respectively. The percentages of CD3-CD16/56+ were 21.65 +/- 1.79, 33.84 +/- 5.45, 38.10 +/- 4.86, and 39.53 +/- 4.80, respectively. The percentages of CD3+CD158b+ were 1.46 +/- 0.31, 1.88 +/- 0.70, 2.03 +/- 1.04, and 0.65 +/- 0.12, respectively. The percentages of CD3-CD16/56+CD158b+ were 5.87 +/- 1.24, 3.57 +/- 0.57, 2.82 +/- 0.45, and 1.60 +/- 0.33, respectively.
  
  
  CONCLUSIONS
  The percentage of CD3+ cells in the normal and the rejection groups decreased significantly. The percentages of CD158b+T cells decreased significantly after acute rejection. The percentage of CD158b+NK cells decreased significantly after kidney transplantation, decreasing gradually after acute rejection. The percentage of CD158b+ total T cells decreased significantly following acute rejection. The percentage of CD3-CD16/56+CD158b+ of total NK cells decreased significantly after kidney transplantation and after acute rejection. Because few factors interfere with the expression of CD158b on NK cells, monitoring of this marker may be accurate and sensitive.
authors.affiliation: The Department of Urology and Pathology, Beijing Chaoyang Hospital, Beijing, China.
authors.forename: N
authors.initials: N
authors.lastname: Kang
authors.forename: D
authors.initials: D
authors.lastname: Guan
authors.forename: N
authors.initials: N
authors.lastname: Xing
authors.forename: C
authors.initials: C
authors.lastname: Xia
mesh_terms: D015703:Antigens, CD / Q000097:blood*; D001402:B-Lymphocytes / Q000382:microbiology; D017252:CD3 Complex / Q000097:blood; D005786:Gene Expression Regulation / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology; D011184:Postoperative Period; D011971:Receptors, Immunologic / Q000097:blood*; D054340:Receptors, KIR; D054344:Receptors, KIR2DL3; D012016:Reference Values; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D015703:Antigens, CD; D017252:CD3 Complex; D011971:Receptors, Immunologic; D054340:Receptors, KIR; D054344:Receptors, KIR2DL3