[Cardiac involvement in Kearns-Sayre syndrome].
The mitochondrial cytopathies or oxidative-phosphorylation diseases are a diverse group of disorders that result from the structural, biochemical, or genetic derangement of mitochondria. Because mitochondrial dysfunction can affect the most highly energy-dependent organs, cardiac involvement is frequent in these diseases. To identify the clinical features of Kearns-Sayre syndrome, an entity associated with this group of diseases, we evaluated cardiac structure and function in 5 patients with Kearns-Sayre syndrome and followed the clinical course of these patients for 5 years.
Barrera-Ramírez
Carlos F
CF
Departamento de Cardiología Intervencionista, Centro Hospitalario La Concepción, Saltillo, México. carlosfbarrera@yahoo.com
Barragán-Campos
Héctor M
HM
Ilarraza
Hermes
H
Iturralde
Pedro
P
Avila-Casado
María C
MC
Oseguera
Jorge
J
D000328:Adult; D005260:Female; D006331:Heart Diseases / Q000209:etiology*; D006801:Humans; D007625:Kearns-Sayre Syndrome / Q000150:complications* / Q000175:diagnosis; D008297:Male