A facile route to paclitaxel C-10 carbamates.
A general protocol for the synthesis of paclitaxel C-10 carbamates is described. The method entails MeI-mediated activation of 2'-O-TBS-7-O-TES-10-O-deacetyl-paclitaxel-10-O-carbonylimidazole prior to reaction with amines. This method is effective for the synthesis of paclitaxel C-10 derivatives, including bifunctional molecules.
Ballatore
Carlo
C
Acidophil, LLC, Suite 250, 10835 Road to the Cure, San Diego, CA 92121, USA.
Aspland
Simon E
SE
Castillo
Rosario
R
Desharnais
Joel
J
Eustaquio
Trisha
T
Sun
Chengzao
C
Castellino
Angelo J
AJ
Smith
Amos B
AB
D002219:Carbamates / Q000737:chemistry*; D017239:Paclitaxel / Q000138:chemical synthesis*
D002219:Carbamates; D017239:Paclitaxel