title: Congenital juvenile granulosa cell tumor of the testis in a fetus showing full 69,XXY triploidy.
abstract: Testicular juvenile granulosa cell tumor (TJGCT) occurs predominantly in infancy and may be associated with sex chromosomal abnormalities. We report a fetus aborted because of cytogenetically confirmed complete XXY triploidy. External genitalia of the fetus were female, with a short and patent vagina. The tumor presented as an abdominal multicystic mass with typical histologic and immunohistological features of JGCT. It was connected with a tubular uterus-like structure. The other gonad was an inguinally localized testis that showed histologically a Sertoli cell adenoma. Malformations typical for triploidy were also present: agenesis of the corpus callosum, stenosis of the pulmonary ostium, and hypoplasia of the lungs and adrenals. To our knowledge this is the first case of TJGCT in a triploid fetus.
authors.affiliation: Institute of Pathology, Medical School University of Zagreb, Zagreb, Croatia.
authors.forename: Marina
authors.initials: M
authors.lastname: Kos
authors.forename: Fernandez Francisco
authors.initials: FF
authors.lastname: Nogales
authors.forename: Milan
authors.initials: M
authors.lastname: Kos
authors.forename: Feodora
authors.initials: F
authors.lastname: Stipoljev
authors.forename: Kristian
authors.initials: K
authors.lastname: Kunjko
mesh_terms: D000025:Abortion, Eugenic; D014408:Biomarkers, Tumor / Q000378:metabolism; D012734:Disorders of Sex Development / Q000235:genetics / Q000473:pathology*; D005260:Female; D005333:Fetus / Q000002:abnormalities*; D006059:Gonadal Dysgenesis; D006106:Granulosa Cell Tumor / Q000151:congenital / Q000235:genetics / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007621:Karyotyping; D008297:Male; D011123:Polyploidy; D013736:Testicular Neoplasms / Q000151:congenital / Q000235:genetics / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor