title: Angiocentric immunoproliferative lesion and angiocentric lymphoma of lymph node in children. A report of two cases.
abstract: OBJECTIVE
  To report two examples of an angiocentric immunoproliferative lesion (AIL) and angiocentric angiodestructive lymphoma (AL) presenting in lymph nodes in children. Most commonly involving extranodal sites, AIL/AL rarely presents in the spleen and lymph nodes.
  
  
  RESULTS
  Case 1 presented as a cervical lymphadenopathy in a 3 year old girl being treated for pre-B cell acute lymphoblastic leukaemia. Histological and immunohistochemistry studies revealed an Epstein-Barr virus positive (EBV+), large B cell (CD20 and CD30+) AIL with large areas of necrosis, the whole resembling lymphomatoid granulomatosis. Case 2 presented as a large supraclavicular lymphadenopathy in a 13 year old boy. Histology and immunohistochemistry revealed an EBV-, large T cell (CD45RO, CD56, and CD30+) AL, presenting the features of so called angiocentric T cell/natural killer cell lymphoma, nasal type.
  
  
  CONCLUSIONS
  The term AIL/AL refers to a heterogeneous group of conditions not unique to a particular type of lymphoid cell. These lesions are easily recognised by the histopathologist because of their extremely unusual angiocentric pattern. Although rare, AIL/AL may present as nodal lesions in children ab initio.
authors.affiliation: Department of Pathology, Hospital de Niños Superiora Sor María Ludovica, 1900, La Plata, Argentina. patologi@netverk.com.ar
authors.forename: R
authors.initials: R
authors.lastname: Drut
authors.forename: R M
authors.initials: RM
authors.lastname: Drut
mesh_terms: D000293:Adolescent; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007160:Immunoproliferative Disorders / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology*; D008206:Lymphatic Diseases / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000473:pathology*; D008230:Lymphomatoid Granulomatosis / Q000473:pathology; D008297:Male