title: Cytologic diagnosis of pulmonary lesions.
abstract: The major types of cytologic preparations used in most laboratories to detect the lesions of the lower respiratory tract (LRT) are examined. These methods include sputum, bronchial washing, bronchial brushing, bronchoalveolar lavage (BAL) and fine-needle aspiration biopsy (FNAB). Sputum represents the simplest and most cost-effective sampling method even though fiberoptic bronchoscopy and radiologic guided FNAB are superseding it as the first diagnostic choice in most cases. There are advantages and disadvantages associated with each technique:bronchial brushing and FNABs tend to preserve both the cellular details and their architectural arrangement whereas sputum and bronchial washing often cause a variable degree of cellular degeneration and fragmentation. As a result, most pulmonary lesions may be detected and correctly diagnosed if multiple techniques are used to acquire diagnostic material. CT-guided FNAB represents the most effective method to achieve a correct diagnosis in pulmonary tumors.
authors.affiliation: Istituto di Anatomia e Istologia Patologica, Università Cattolica del S. Cuore, Policlinico "A. Gemelli", Roma, Italy. esterossi@yahoo.com
authors.forename: Esther Diana
authors.initials: ED
authors.lastname: Rossi
authors.forename: Antonino
authors.initials: A
authors.lastname: Mulè
authors.forename: Claudia
authors.initials: C
authors.lastname: Maggiore
authors.forename: Antonella
authors.initials: A
authors.lastname: Miraglia
authors.forename: Libero
authors.initials: L
authors.lastname: Lauriola
authors.forename: Fabio Maria
authors.initials: FM
authors.lastname: Vecchio
authors.forename: Guido
authors.initials: G
authors.lastname: Fadda
mesh_terms: D044963:Biopsy, Fine-Needle; D018893:Bronchoalveolar Lavage; D001999:Bronchoscopy; D003937:Diagnosis, Differential; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D013183:Sputum / Q000166:cytology