The discovery of the CCR5 receptor antagonist, UK-427,857, a new agent for the treatment of HIV infection and AIDS.
Wood
Anthony
A
Department of Chemistry, Pfizer Global Research and Development, Sandwich Laboratories, Sandwich, Kent, UK.
Armour
Duncan
D
D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D065100:CCR5 Receptor Antagonists; D054407:Chemokine CCL4; D003510:Cyclohexanes / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D006801:Humans; D019402:Macrophage Inflammatory Proteins / Q000378:metabolism; D000077592:Maraviroc; D011485:Protein Binding; D011869:Radioligand Assay; D019713:Receptors, CCR5 / Q000737:chemistry; D015728:Receptors, HIV / Q000187:drug effects; D014230:Triazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism
D019380:Anti-HIV Agents; D065100:CCR5 Receptor Antagonists; D054407:Chemokine CCL4; D003510:Cyclohexanes; D019402:Macrophage Inflammatory Proteins; D019713:Receptors, CCR5; D015728:Receptors, HIV; D014230:Triazoles; D000077592:Maraviroc