[Chromosomal aberration in human keloid analyzed by comparative genomic hybridization].
OBJECTIVE
To identify the genetic alteration in human keloid.


METHODS
Comparative genomic hybridization was applied in 6 cases of keloid to investigate the genomic imbalance (the gain or loss of genetic material).


RESULTS
The study showed that the loss of chromosome DNA copies included chromosome, 1,7,9,13,16,17,18,19,20,22. Among them, the frequently detected chromosome loss was chromosome 1 p(66.7%), 16 (83.3%), 20 (83.3%) and 22 (83.3%). The minimum overlapping regions were 1 pter-32.2,16p13.2p11.l,20q11.1-q13.2 and 16p13.2-p11.1. Frequent gain of DNA copy numbers was not found in the special regions.


CONCLUSIONS
The mapping of DNA copy variation frequency in keloid showed that there may be inhibitory genes in chromosomes 1p,16,20,22. The loss of these genes may be involved in the development and progress of keloid.
Zhang
Gang
G
The Institute of Plastic Surgery, Guangdong Medical College, Zhanjiang 524001, China.
Luo
Shao-jun
SJ
Tang
Shao-ming
SM
Liang
Jie
J
D000328:Adult; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D055028:Comparative Genomic Hybridization; D015342:DNA Probes; D005260:Female; D006801:Humans; D007627:Keloid / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
D015342:DNA Probes