Renoprotective effect of grape seeds extract in ethylene glycol induced nephrotoxic mice.
Grape seed extract treatment in ethylene glycol (EG) induced nephrotoxic mice improved antioxidant status and significantly decreased urinary lactate dehydrogenase (LDH) and lipid peroxidation. The extract rendered antioxidant protection against oxidative stress induced by EG and may help in protecting renal tissue against EG toxicity.
Mohanasundari
M
M
Department of Zoology, Rajah Muthiah Medical College, Annamalai University, Annamalai Nagar, India.
Sabesan
M
M
Sethupathy
S
S
D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D004195:Disease Models, Animal; D019855:Ethylene Glycol / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D015227:Lipid Peroxidation / Q000187:drug effects; D051379:Mice; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry; D027843:Vitis / Q000737:chemistry*
D000975:Antioxidants; D010936:Plant Extracts; D019855:Ethylene Glycol