[HOXB gene family and functions of hematopoietic stem/progenitor cells--review].
Recently, many researches indicated the important role played by homeobox (HOX) gene family in normal hematopoiesis. As a kind of transcription factors, HOX gene products regulate and control the expression of target genes by binding to special DNA sequences. HOXB, a member of HOX gene family, especially HOXB(4), interests people greatly. It has been found that its expression relates closely to the self-renewal of hematopoietic stem cells and effective proliferation of hematopoietic progenitor cells. This review presents some new research progress in this area.
Tang
Yu-Hong
YH
Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. yuhongtang@sina.com
Wang
Cheng-Ya
CY
D000818:Animals; D006410:Hematopoiesis / Q000235:genetics / Q000276:immunology / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D018398:Homeodomain Proteins / Q000235:genetics* / Q000502:physiology; D006801:Humans; D005810:Multigene Family
D018398:Homeodomain Proteins