Application of molecular diagnostic techniques to renal epithelial neoplasms.
The application of molecular and cytogenetic techniques to the study of renal neoplasia has resulted in improved understanding of the biologic mechanisms that are responsible for tumor development and progression. It also revealed that several different and specific genetic events are responsible for tumorigenesis in the various categories and subcategories of renal tumors. The ultimate goal of research on the molecular pathology of renal neoplasms is a complete understanding of the genetics of these tumors, which will, in turn, aid in making the correct diagnosis, accurately assessing prognosis, and selecting appropriate and targeted therapeutic options.
Jones
Timothy D
TD
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indiana University Medical Center, University Hospital, Indianapolis, IN 46202, USA.
Eble
John N
JN
Cheng
Liang
L
D018262:Adenocarcinoma, Clear Cell / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D018249:Adenoma, Oxyphilic / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D002291:Carcinoma, Papillary / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D004268:DNA-Binding Proteins / Q000235:genetics; D018628:Gene Dosage; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D019656:Loss of Heterozygosity; D014157:Transcription Factors / Q000235:genetics
D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D004268:DNA-Binding Proteins; C069203:TFE3 protein, human; D014157:Transcription Factors