Iso-, nor-, and dinor-spiculoic acids A, polyketides from the marine sponge Plakortis zyggompha.
The new iso-, nor-, and dinor-spiculoic acids A (1, 2, and 3, respectively) with a rare spiculane skeleton were isolated from the marine sponge Plakortis zyggompha, collected in the waters south of Martinique. The structural determination of the compounds was based on 1D and 2D NMR studies and mass spectral determinations. Compounds 1 and 2 showed weak cytotoxicity against the two tumor cell lines A549 and HT29.
Berrué
Fabrice
F
Laboratoire de Chimie Bioorganique, UMR 6001 CNRS, Faculté des Science, UNSA, Parc Valrose, 06108 Nice Cedex 02, France.
Thomas
Olivier P
OP
Fernández
Rogelio
R
Amade
Philippe
P
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002264:Carboxylic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D007189:Indans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D047229:Plakortis / Q000737:chemistry*; D013030:Spain; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D002264:Carboxylic Acids; D007189:Indans; C500767:dinor-spiculoic acid A; C500765:iso-spiculoic acid A; C500766:nor-spiculoic acid A