The antioxidant effect of beta-Glucan on oxidative stress status in experimental spinal cord injury in rats.
This study was performed to investigate the antioxidant effect of beta-Glucan in experimental spinal cord injury (SCI). Injury was produced using weight-drop technique in rats. beta-Glucan was given by intraperitoneal injection following trauma. The rats were sacrificed at the sixth day of injury. Oxidative stress status was assessed by measuring the spinal cord tissue content of Malonyldialdehyde (MDA), Superoxide Dismutase (SOD) and Gluthatione Peroxidase (GSH-Px) activities. No effect of beta-Glucan on SOD and MDA activities was found but, GSH-Px levels were found to decrease to the baseline (preinjury) levels when it was compared to untreated group (U=0.000; p=0.002). According to our results, beta-Glucan works like a scavenger and has an antioxidant effect on lipid peroxidation in spinal cord injury.
Kayali
Hakan
H
Department of Neurosurgery, Gulhane Military Medical Academy, 06018 Etlik, Ankara, Turkey. hakankayali@hotmail.com
Ozdag
M Fatih
MF
Kahraman
Serdar
S
Aydin
Ahmet
A
Gonul
Engin
E
Sayal
Ahmet
A
Odabasi
Zeki
Z
Timurkaynak
Erdener
E
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology; D005979:Glutathione Peroxidase / Q000378:metabolism; D007274:Injections, Intraperitoneal; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013119:Spinal Cord Injuries / Q000378:metabolism* / Q000473:pathology; D013482:Superoxide Dismutase / Q000378:metabolism; D047071:beta-Glucans / Q000494:pharmacology*
D000975:Antioxidants; D016166:Free Radical Scavengers; D047071:beta-Glucans; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase