AKA-Glucose: a program for kinetic and epidemiological analysis of frequently sampled intravenous glucose tolerance test data using database technology.
BACKGROUND
The Bergman Minimal Model enables estimation of two key indices of glucose/ insulin dynamics: glucose effectiveness and insulin sensitivity.


RESULTS
In this paper we describe AKA-Glucose, a program that combines MINMOD Millennium (minimal model analysis software) with relational database technologies. AKA-Glucose enables the fitting of individual frequently sampled intravenous glucose tolerance test (FSIGT) data sets to the Minimal Model and the secure storage in a dedicated database (and retrieval from) of thousands of individual subjects' demographic data, their individual FSIGT data, and each subject's parameters and indices derived from minimal model analysis. AKA-Glucose also enables the population analysis of various strata or subpopulations within the database. AKA-Glucose has all of the capabilities of MINMOD Millennium, provides Minimal Model parameter estimates that are concordant with estimates from previous MINMOD software, and allows importation of data files from earlier versions of the MINMOD software.


CONCLUSIONS
By combining FSIGT data fitting, population analysis, and relational database technologies, AKA-Glucose is the first minimal model software designed specifically for researchers confronted with minimal model and epidemiological analysis of large numbers of either human or animal FSIGT data sets.
Boston
Raymond C
RC
School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania 19348, USA. boston@vet.upenn.edu
Moate
Peter J
PJ
Stefanovski
Darko
D
Sumner
Anne E
AE
Bergman
Richard N
RN
D000328:Adult; D001741:Black or African American; D001786:Blood Glucose / Q000378:metabolism*; D003196:Computer Graphics; D016208:Databases, Factual; D004812:Epidemiologic Methods; D005260:Female; D005951:Glucose Tolerance Test / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D015233:Models, Statistical; D011153:Population; D012984:Software; D014584:User-Computer Interface
D001786:Blood Glucose