The purinergic P2X7 receptor is not required for control of pulmonary Mycobacterium tuberculosis infection.
The importance in vivo of P2X7 receptors in control of virulent Mycobacterium tuberculosis was examined in a low-dose aerosol infection mouse model. P2X7(-/-) mice controlled infection in lungs as well as wild-type mice, suggesting that the P2X7 receptor is not required for control of pulmonary M. tuberculosis infection.
Myers
Amy J
AJ
Department of Medicine, Division of Infectous Disease, BRB 1029, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4984, USA.
Eilertson
Brandon
B
Fulton
Scott A
SA
Flynn
Joanne L
JL
Canaday
David H
DH
D000818:Animals; D017951:Antigen Presentation; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D008168:Lung / Q000276:immunology / Q000382:microbiology; D008198:Lymph Nodes / Q000276:immunology / Q000382:microbiology; D008264:Macrophages / Q000276:immunology / Q000382:microbiology; D051379:Mice; D008810:Mice, Inbred C57BL; D009169:Mycobacterium tuberculosis / Q000472:pathogenicity*; D018048:Receptors, Purinergic P2 / Q000378:metabolism*; D058486:Receptors, Purinergic P2X7; D014397:Tuberculosis, Pulmonary / Q000276:immunology* / Q000382:microbiology
C546469:P2rx7 protein, mouse; D018048:Receptors, Purinergic P2; D058486:Receptors, Purinergic P2X7