Neuronal leucine-rich repeat protein 4 functions in hippocampus-dependent long-lasting memory.
Neuronal leucine-rich repeat proteins (NLRRs) are type I transmembrane proteins and expressed in neuronal tissues, but their function remains unknown. Here, we describe the identification and characterization of a new member of the NLRR family, NLRR4, and its potential role in long-lasting memory. We generated NLRR4-deficient (NLRR4(-/-)) mice and found that they showed impaired memory retention. In hippocampus-dependent learning tasks, NLRR4(-/-) mice were able to learn and maintain the memories for one day but unable to retain the memories for four days after learning. In contrast, in a hippocampus-independent task, NLRR4(-/-) mice were able to retain the memory normally for at least seven days. These results suggest that NLRR4 plays a key role in hippocampus-dependent long-lasting memory.
Bando
Takayoshi
T
Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Sekine
Keisuke
K
Kobayashi
Shizuka
S
Watabe
Ayako M
AM
Rump
Armin
A
Tanaka
Minoru
M
Suda
Yoshikuni
Y
Kato
Shigeaki
S
Morikawa
Yoshihiro
Y
Manabe
Toshiya
T
Miyajima
Atsushi
A
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D003001:Cloning, Molecular; D003463:Cues; D005239:Fear / Q000502:physiology; D017353:Gene Deletion; D006624:Hippocampus / Q000378:metabolism / Q000502:physiology* / Q000503:physiopathology; D017774:Long-Term Potentiation / Q000502:physiology; D018782:Maze Learning / Q000502:physiology; D008565:Membrane Proteins / Q000737:chemistry / Q000172:deficiency / Q000235:genetics* / Q000378:metabolism*; D008568:Memory / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000172:deficiency / Q000235:genetics* / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology
D008565:Membrane Proteins; C501080:NLRR4 protein, mouse; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger