title: Alcohol withdrawal prophylaxis in patients undergoing surgical treatment of head and neck squamous cell carcinoma.
abstract: OBJECTIVE
  Alcohol abuse is common in patients with squamous cell cancer of the head and neck. Postoperative alcohol withdrawal is associated with increased morbidity and prolonged hospitalization and is commonly treated with benzodiazepines. We reviewed our experience with benzodiazepine prophylaxis in high-risk patients undergoing surgical treatment of head and neck cancer. We sought to determine whether benzodiazepine prophylaxis was successful in preventing complications from alcohol withdrawal.
  
  
  METHODS
  Nonrandomized, retrospective patient analysis.
  
  
  METHODS
  The medical records of all patients diagnosed with squamous cell carcinoma of the head and neck from 1999 to 2004 were retrospectively reviewed. Patients who underwent surgical resection and who were considered high risk for postoperative alcohol withdrawal received benzodiazepine prophylaxis following an established institutional protocol and comprised the study group.
  
  
  RESULTS
  Of 96 patients who met study criteria, 13 (13.5%) patients developed alcohol withdrawal symptoms, and 9 (9.4%) patients developed delirium tremens. Patients who manifested alcohol withdrawal remained in the hospital an average of 10.8 days longer (19.0 vs. 8.2) and had an overall complication rate of 50% (11 of 22) versus a 17.6% (13 of 74) complication rate in patients that did not develop withdrawal (P < .05).
  
  
  CONCLUSIONS
  Alcohol withdrawal is associated with a significantly greater incidence of postoperative complications and duration of hospitalization. Benzodiazepine prophylaxis does not prevent postoperative alcohol withdrawal symptoms in all patients at risk. Alternate methods of prophylaxis should be explored.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Medical College of Georgia, Augusta, Georgia. USA.
authors.forename: Kimberly M
authors.initials: KM
authors.lastname: Neyman
authors.forename: Christine G
authors.initials: CG
authors.lastname: Gourin
authors.forename: David J
authors.initials: DJ
authors.lastname: Terris
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000534:rehabilitation*; D002294:Carcinoma, Squamous Cell / Q000601:surgery*; D000431:Ethanol / Q000009:adverse effects; D005260:Female; D018757:GABA Modulators / Q000627:therapeutic use; D006258:Head and Neck Neoplasms / Q000601:surgery*; D006801:Humans; D008140:Lorazepam / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D013517:Otorhinolaryngologic Surgical Procedures; D010348:Patient Care Team; D011184:Postoperative Period; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D011795:Surveys and Questionnaires
chemical_list: D018757:GABA Modulators; D000431:Ethanol; D008140:Lorazepam