Interactions of NF-kappaB with chromatin: the art of being at the right place at the right time.
Transcription factors of the NF-kappaB family are essential regulators of the inflammatory and immune responses. The main 'switch' in NF-kappaB activation is cytoplasmic and leads to the release of NF-kappaB proteins from IkappaB molecules, specific inhibitors that prevent their nuclear accumulation. However, it is becoming increasingly apparent that in addition to this required activation step, both recruitment of NF-kappaB to target genes and NF-kappaB-induced transcriptional events after recruitment are actively controlled. Regulated recruitment of NF-kappaB to chromatin generates kinetic complexity in NF-kappaB-dependent gene induction and 'wires' NF-kappaB-regulated gene activity to simultaneously activated pathways and transcription factors.
Natoli
Gioacchino
G
Institute for Research in Biomedicine, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland. gioacchino.natoli@irb.unisi.ch <gioacchino.natoli@irb.unisi.ch>
Saccani
Simona
S
Bosisio
Daniela
D
Marazzi
Ivan
I
D000818:Animals; D001665:Binding Sites; D002843:Chromatin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004247:DNA / Q000235:genetics / Q000378:metabolism; D019281:Dimerization; D006801:Humans; D016328:NF-kappa B / Q000737:chemistry / Q000378:metabolism*; D009707:Nucleosomes / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
D002843:Chromatin; D016328:NF-kappa B; D009707:Nucleosomes; D004247:DNA