title: Successful treatment of malignant melanoma in situ with topical 5% imiquimod cream.
abstract: BACKGROUND
  Current treatment recommendations for malignant melanoma in situ include surgical excision with at least 0.5 cm margins. On the head or neck, obtaining adequate surgical margins for melanoma can be challenging and often disfiguring. In addition, some elderly patients may not be good surgical candidates and may request less aggressive interventions.
  
  
  METHODS
  We report herein three cases of malignant melanoma in situ on the face treated with topical imiquimod cream.
  
  
  RESULTS
  Complete regression of malignant melanoma in situ was observed on treatment with 5% topical imiquimod cream. The varied treatment regimens, rationale for using imiquimod rather than performing surgery, and the possible mechanisms of action are discussed.
  
  
  CONCLUSIONS
  Topical imiquimod can be used successfully for the treatment of malignant melanoma in situ on the face.
authors.affiliation: University of Connecticut Health Center, Department of Hematology/Oncology, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030, USA.
authors.forename: Carolyn M
authors.initials: CM
authors.lastname: Ray
authors.forename: Michael
authors.initials: M
authors.lastname: Kluk
authors.forename: Caron M
authors.initials: CM
authors.lastname: Grin
authors.forename: Jane M
authors.initials: JM
authors.lastname: Grant-Kels
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D000369:Aged, 80 and over; D000634:Aminoquinolines / Q000008:administration & dosage*; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005153:Facial Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D000077271:Imiquimod; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D000077271:Imiquimod