A polymorphism in the matrix metalloproteinase-1 gene promoter is associated with the presence of polycystic ovary syndrome in Caucasian women.
A common -1607 GG/G polymorphism of the matrix metalloproteinase-1 (MMP1) gene promoter was investigated in a series of Caucasian women with polycystic ovary syndrome (PCOS) and controls, by direct sequencing. In this prospective case-control study, the odds for women with at least one mutant GG allele of the MMP1 promoter to be diagnosed with PCOS was 2.7.
Walch
Katharina
K
Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, Austria. katharina.walch@meduniwien.ac.at
Nagele
Friedrich
F
Zeillinger
Robert
R
Vytiska-Binstorfer
Elisabeth
E
Huber
Johannes C
JC
Hefler
Lukas A
LA
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000235:genetics*; D016017:Odds Ratio; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011446:Prospective Studies; D044465:White People / Q000235:genetics*
D020781:Matrix Metalloproteinase 1