[Progress in the molecular mechanisms of nuclear coactivator PGC-1].
Peroxisome proliferators-activated receptor-gamma coactivator-1 is broadly involved in several key cellular pathways including mitochondrial biogenesis, hepatic gluconeogenesis via interacting with many transcription factors, which is highly valuable to maintain the energy balance of organisms. This review especially focuses on the recent progress in the molecular docking, histone acetylation, RNA processing basing on the structure of PGC-1 gene and amino acid sequence. Besides, the prospect of PGC-1 in applications of metabolic syndromes has been discussed also.
Sun
Liang
L
Institute of Geriatrics, Ministry of Health, Beijing Hospital, Beijing 100730, China. sunl90@genetics.ac.cn
Jin
Feng
F
Wang
Li
L
Yang
Ze
Z
D000107:Acetylation; D000595:Amino Acid Sequence; D000818:Animals; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D008969:Molecular Sequence Data; D012326:RNA Splicing; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
D006657:Histones; D014157:Transcription Factors; C111264:peroxisome-proliferator-activated receptor-gamma coactivator-1; D048051:p38 Mitogen-Activated Protein Kinases