Hyperacute renal failure as the initial presentation of systemic lupus erythematosus.
SLE nephritis is usually a slow process that may lead to renal failure many years after its first presentation. Success of different therapeutic modalities in preventing renal failure is therefore evaluated and compared only after many years of treatment. Lately, this conservative philosophy has been challenged with the acknowledgment of collapsing glomerulopathy (CG), a recent recognized clinical-pathological entity, characterized by rapidly progressive renal failure. Despite this ominous description we present an unusual case of a patient who presented with systemic lupus erythematosus (SLE) and clinical and pathological findings of CG, who completely remitted several weeks after commencing immunosuppressive therapy with intravenous cyclophosphamide and prednisolone.
Arbel
O
O
Department of Medicine, Hadassah University Hospital, Jerusalem, Israel.
Pizov
G
G
Ben-Yehuda
A
A
Rubinow
A
A
Naparstek
Y
Y
Amital
H
H
D058186:Acute Kidney Injury / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D000328:Adult; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy; D008181:Lupus Nephritis / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D008854:Microscopy, Electron; D011239:Prednisolone / Q000627:therapeutic use; D012074:Remission Induction; D013997:Time Factors
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D011239:Prednisolone