title: Initial distribution volume of glucose is correlated with intrathoracic blood volume in hypovolaemia and following volume loading in dogs.
abstract: OBJECTIVE
  Initial distribution volume of glucose (IDVG) reliably measures the central extracellular fluid volume in the presence of fluid gain or loss. We hypothesized that IDVG has a close relationship with intrathoracic blood volume (ITBV), which has recently been used as an indicator of cardiac preload. We therefore examined whether IDVG can correlate with ITBV in various fluid volume states.
  
  
  METHODS
  Fourteen anaesthetized mongrel dogs were mechanically ventilated. ITBV and cardiac output were measured by single transpulmonary thermodilution technique. IDVG and indocyanine green derived plasma volume (PV-ICG) were determined by the administration of 100 mg kg(-1) glucose and 0.5 mg kg(-1) indocyanine green solutions, respectively, and calculated by applying a one-compartment model. Three sets of measurements were performed before and after haemorrhage (30 mL kg(-1) and subsequent fluid volume loading (90 mL kg(-1) of lactated Ringer's solution).
  
  
  RESULTS
  A linear correlation was observed between IDVG and ITBV (r2 = 0.52, n = 42, P < 0.001) and between PV-ICG and ITBV (r2 = 0.44, n = 42, P < 0.001) throughout the procedures. A linear correlation was also observed between changes in IDVG and those in ITBV (r2 = 0.76, n = 28, P < 0.001). The ITBV/IDVG ratio during normovolaemia was 0.26 +/- 0.04, which remained unchanged during the procedure.
  
  
  CONCLUSIONS
  Results showed that that IDVG has a linear correlation with ITBV, and support the concept that IDVG measurement has potential as a surrogate measure of ITBV in various fluid volume states.
authors.affiliation: University of Hirosaki School of Medicine, Department of Anesthesiology, Hirosaki-Shi, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
authors.forename: H
authors.initials: H
authors.lastname: Ishihara
authors.forename: H
authors.initials: H
authors.lastname: Okawa
authors.forename: Y
authors.initials: Y
authors.lastname: Yatsu
authors.forename: T
authors.initials: T
authors.lastname: Tsubo
authors.forename: A
authors.initials: A
authors.lastname: Matsuki
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D001810:Blood Volume / Q000502:physiology*; D002302:Cardiac Output / Q000502:physiology; D004396:Coloring Agents; D004285:Dogs; D045604:Extracellular Fluid / Q000378:metabolism; D005947:Glucose / Q000493:pharmacokinetics*; D006470:Hemorrhage / Q000503:physiopathology; D007022:Hypotension / Q000503:physiopathology; D020896:Hypovolemia / Q000378:metabolism / Q000503:physiopathology*; D007208:Indocyanine Green; D007552:Isotonic Solutions / Q000627:therapeutic use; D010952:Plasma Substitutes / Q000627:therapeutic use; D010953:Plasma Volume / Q000502:physiology; D000077325:Ringer's Lactate; D013815:Thermodilution; D013909:Thorax
chemical_list: D001786:Blood Glucose; D004396:Coloring Agents; D007552:Isotonic Solutions; D010952:Plasma Substitutes; D000077325:Ringer's Lactate; D007208:Indocyanine Green; D005947:Glucose