Intramolecular hydroamination of unactived olefins with Ti(NMe2)4 as a precatalyst.
Commercially available Ti(NMe(2))(4) has been used effectively as a precatalyst in a facile protocol for the intramolecular hydroamination of aminoalkenes to yield pyrrolidine and piperidine heterocyclic products with isolated yields up to 92%. Geminally substituted substrates display the highest reactivity. This precatalyst is also effective for the hydroamination of activated internal alkenes, providing access to more complex heterocyclic target molecules.
Bexrud
Jason A
JA
Department of Chemistry, University of British Columbia, Vancouver, Canada.
Beard
J David
JD
Leitch
David C
DC
Schafer
Laurel L
LL