Corneal endothelial deposits associated with rifabutin use.
OBJECTIVE
The aim of this study was to report on the possible development of corneal endothelial deposits resulting from the use of rifabutin.


METHODS
Case series consisting of 3 patients treated with rifabutin were retrospectively studied. Two of the patients were infected with human immunodeficiency virus. A corneal and external disease specialist performed a complete ophthalmologic exam and obtained medical histories of the patients.


RESULTS
All cases developed corneal endothelial deposits after previous use of rifabutin. The deposits were bilateral, yellow-white colored, stellate, and mainly peripheral.


CONCLUSIONS
In these 3 cases, the unique positive ocular finding was corneal endothelial deposits, which may be related to the use of rifabutin.
Coutinho
Anamaria Baptista
AB
Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil. anamariacoutinho@hotmail.com
Cheema
Devinder
D
Pereira
Patricia R
PR
Souza Filho
João P
JP
Burnier
Miguel N
MN
D017088:AIDS-Related Opportunistic Infections / Q000517:prevention & control*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D003941:Diagnostic Techniques, Ophthalmological; D004334:Drug Administration Schedule; D004728:Endothelium, Corneal / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015270:Mycobacterium avium-intracellulare Infection / Q000517:prevention & control*; D012189:Retrospective Studies; D017828:Rifabutin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D014388:Tuberculosis, Lymph Node / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D017828:Rifabutin