Asymmetric and axisymmetric constant curvature liquid-gas interfaces in pulmonary airways.
Airway closure and gas trapping can occur during lung deflation and inflation when fluid menisci form across the lumina of respiratory passageways. Previous analyses of the behavior of liquid in airways have assumed that the airway is completely wetted or that the contact angle of the liquid-gas interface with the airway wall is 0 degrees, and thus that the airway fluid forms an axisymmetric surface. However, some investigators have suggested that liquid in the airways is discontinuous and that contact angles can be as high as 67 degrees. In this study we consider the characteristics of constant curvature surfaces that could form a stable liquid-gas interface in a cylindrical airway. Our analysis suggests that, for small liquid volumes, asymmetric droplets are more likely to form than axisymmetric toroids. In addition, if the fluid contact angle is greater than 13 degrees, asymmetric droplets can sustain larger liquid volumes than axisymmetric toroids before collapsing to form menisci. These results suggest that (1) fluid formations other than axisymmetric toroids could occur in the airways; and (2) the analysis of the behavior of fluids and the development of liquid menisci within the lungs should include the potential role of asymmetric droplets.
Lindsley
William G
WG
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA. wlindsley@cdc.gov
Collicott
Steven H
SH
Franz
Gunter N
GN
Stolarik
Brian
B
McKinney
Walter
W
Frazer
David G
DG
D000402:Airway Obstruction / Q000503:physiopathology*; D000818:Animals; D016880:Anisotropy; D003198:Computer Simulation; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008954:Models, Biological; D011659:Pulmonary Gas Exchange / Q000502:physiology*; D011663:Pulmonary Surfactants / Q000378:metabolism*; D020545:Respiratory Mucosa / Q000503:physiopathology*; D012996:Solutions; D013499:Surface Properties; D014132:Trachea / Q000503:physiopathology*
D011663:Pulmonary Surfactants; D012996:Solutions