title: Hexagonal zero mode TEM coil: a single-channel coil design for imaging multiple small animals.
abstract: A novel hexagonal coil design for simultaneous imaging of multiple small animals is presented. The design is based on a coaxial cavity and utilizes the magnetic field formed between two coaxial conductors with hexagonal cross-sections. An analytical solution describing the B(1) field between conductors of the hexagonal coil was found from the Biot-Savart law. Both experimental results and analytical calculations showed a variation in the B(1) field within the imaging region of less than 10%. Numerical calculations predicted approximately 35% improvement in B(1) field homogeneity with the hexagonal coil design compared to a cylindrical coaxial cavity design. The experimentally-measured signal-to-noise ratio (SNR) of the hexagonal coil loaded with six 50-mM phantoms was only 4-5% lower than that of a single parallel plate resonator loaded with one phantom. In vivo spin-echo (SE) images of six 7-day-old rat pups acquired simultaneously demonstrated sufficient SNR for microimaging. The construction scheme of the coil, simple methods for tuning and matching, and an anesthesia device and animal holder designed for the coil are described. The hexagonal coil design utilizes a single receiver and allows for simultaneous imaging of six small animals with no significant compromise in SNR.
authors.affiliation: Center for NMR Research, Department of Radiology, Pennsylvania State University College of Medicine, Hershey, 17033, USA.
authors.forename: Jelena
authors.initials: J
authors.lastname: Lazovic
authors.forename: Dragan S
authors.initials: DS
authors.lastname: Stojkovic
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Collins
authors.forename: Qing X
authors.initials: QX
authors.lastname: Yang
authors.forename: J Thomas
authors.initials: JT
authors.lastname: Vaughan
authors.forename: Michael B
authors.initials: MB
authors.lastname: Smith
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004867:Equipment Design; D006257:Head / Q000033:anatomy & histology; D007089:Image Enhancement / Q000295:instrumentation*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D019047:Phantoms, Imaging; D051381:Rats