Intracerebroventricularly administered urocortin inhibits gastric emptying in mice.
Urocortin, a recently identified member of the corticotropin-releasing factor (CRF) family, is implicated in the central control of appetite and energy metabolism. We previously reported that peripherally administered urocortin inhibits gastric emptying in conscious mice. In this study, we investigated the effect of intracerebroventricularly administered urocortin on gastric emptying, food intake and body weight in mice. Urocortin decreased food intake and body weight gain more potently than CRF. It significantly decreased gastric emptying of a solid meal; an effect that was inhibited by simultaneous administration of alpha-helical CRF9-41, a CRF antagonist. These results suggest that the potent anorectic properties of urocortin may be partly due to the anti-gastroprokinetic activity of the peptide.
Nagata
Toshiaki
T
Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Uemoto
Masaharu
M
Yuzuriha
Hideki
H
Asakawa
Akihiro
A
Inui
Akio
A
Fujimiya
Mineko
M
Sakamaki
Ruka
R
Kasuga
Masato
M
Shinfuku
Naotaka
N
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003346:Corticotropin-Releasing Hormone / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D005508:Food Deprivation / Q000502:physiology; D005746:Gastric Emptying / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D054832:Urocortins
D054832:Urocortins; D003346:Corticotropin-Releasing Hormone