Uterine sarcoidosis potentially associated with interferon-alpha use for chronic hepatitis C infection.
BACKGROUND
A regimen including interferon-alpha has become the standard of care in the treatment of chronic hepatitis C over the last decade. One rare adverse effect associated with the use of interferon-alpha is a granulomatous pulmonary reaction.


METHODS
A unique case of uterine sarcoidosis associated with the use of interferon-alpha for chronic hepatitis C infection is presented.


CONCLUSIONS
Gynecologists should be aware of a potential association between interferon-alpha therapy and granulomatous reactions occurring not only in the lung but also in the female genital tract.
Tsiodras
Sotirios
S
Henry Dunant Hospital, Athens, Greece. stsiodra@caregroup.harvard.edu
Drimala
Panagiota
P
Stavreas
Nick
N
Dachlythras
Marios
M
Alamani
Anna Maria
AM
Naoum
George
G
D001707:Biopsy, Needle; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D019698:Hepatitis C, Chronic / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007150:Immunohistochemistry; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D011994:Recombinant Proteins; D018570:Risk Assessment; D012507:Sarcoidosis / Q000139:chemically induced* / Q000473:pathology; D012720:Severity of Illness Index; D014591:Uterine Diseases / Q000139:chemically induced* / Q000473:pathology
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins