Low levels of human immunodeficiency virus type 1 DNA in high-risk seronegative men.
We detected human immunodeficiency virus type 1 (HIV-1) DNA at very low levels in sequential peripheral blood mononuclear cell samples of five out of six high-risk, seronegative, homosexual men and five out of five individuals 7.8 to 1.6 years prior to seroconversion. These data indicate a high prevalence of low-level HIV-1 DNA in exposed seronegative individuals.
Koning
Fransje A
FA
Sanquin Research at CLB, Dept. of Clinical Viro Immunology, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands.
van der Vorst
Teun J K
TJ
Schuitemaker
Hanneke
H
D000595:Amino Acid Sequence; D004279:DNA, Viral / Q000097:blood*; D005500:Follow-Up Studies; D015684:Gene Products, pol / Q000235:genetics; D014644:Genetic Variation; D015658:HIV Infections / Q000175:diagnosis / Q000821:virology*; D020276:HIV Long-Term Survivors; D018023:HIV Seronegativity; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification*; D006716:Homosexuality; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000821:virology; D008297:Male; D008969:Molecular Sequence Data; D011533:Proviruses / Q000235:genetics / Q000302:isolation & purification; D016415:Sequence Alignment
D004279:DNA, Viral; D015684:Gene Products, pol