Ceftriaxone-induced symptomatic pseudolithiasis mimicking ICP elevation.
In neurosurgery, ceftriaxone is a widely used, third generation cephalosporin for the treatment of CNS infections and perioperational prophylaxis. Recent studies have demonstrated that ceftriaxone induces reversible precipitates in the gallbladder. This complication is referred to as "biliary pseudolithiasis", and it has symptoms similar to the raised intracranial pressure (ICP) symptoms of the perioperative period. Symptomatic biliary pseudolithiasis should be kept in mind in all pediatric neurosurgery cases under ceftriaxone therapy in order to prevent unnecessary postoperative investigations and surgery.
Evliyaoglu
C
C
Department of Neurosurgery, Kirikkale University School of Medicine, Kirikkale, Turkey. cevliyaoglu@hotmail.com
Kizartici
T
T
Bademci
G
G
Unal
B
B
Keskil
S
S
D000293:Adolescent; D002443:Ceftriaxone / Q000009:adverse effects*; D002511:Cephalosporins / Q000009:adverse effects*; D002551:Cerebral Ventricle Neoplasms / Q000150:complications / Q000601:surgery; D002648:Child; D002769:Cholelithiasis / Q000139:chemically induced* / Q000175:diagnosis* / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D004677:Encephalocele / Q000150:complications / Q000601:surgery; D006801:Humans; D019586:Intracranial Hypertension / Q000139:chemically induced* / Q000175:diagnosis*; D007427:Intracranial Pressure / Q000187:drug effects*; D008279:Magnetic Resonance Imaging; D008297:Male; D019635:Neurosurgical Procedures; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
D002511:Cephalosporins; D002443:Ceftriaxone