title: Fluorapatite-mullite glass sputter coated Ti6Al4V for biomedical applications.
abstract: A number of bioactive ceramics have been researched since the development of Bioglass in the 1970's. Fluorapatite mullite has been developed from the dental glass-ceramics used for more general hard tissue replacement. Being brittle in nature, glass-ceramics are currently used mainly as coatings. This paper shows that fluorapatite glass LG112 can be used as a sputtered glass coating on roughened surfaces of Ti6Al4V for possible future use for medical implants. An AFM was used to measure the roughness of the surface before and after coating to determine the change in the topography due to the coating process as this greatly affects cell attachment. The sputter coating partially filled in the artificially roughened surface, changing the prepared topography. Osteoblasts have been successfully grown on the surface of these coatings, showing biocompatibility with bone tissue and therefore potential use in hard tissue repair.
authors.affiliation: School of Materials, University of Manchester, Grosvenor Street, Manchester, M1 7HS.
authors.forename: J K
authors.initials: JK
authors.lastname: Bibby
authors.forename: N L
authors.initials: NL
authors.lastname: Bubb
authors.forename: D J
authors.initials: DJ
authors.lastname: Wood
authors.forename: P M
authors.initials: PM
authors.lastname: Mummery
mesh_terms: D000497:Alloys; D000538:Aluminum Silicates / Q000032:analysis / Q000737:chemistry*; D001031:Apatites / Q000032:analysis / Q000737:chemistry*; D001698:Biomedical Engineering / Q000379:methods; D018786:Bone Substitutes / Q000032:analysis / Q000737:chemistry*; D002460:Cell Line; D049109:Cell Proliferation; D002470:Cell Survival; D020099:Coated Materials, Biocompatible / Q000032:analysis / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing; D010006:Osteoblasts / Q000166:cytology*; D013499:Surface Properties; D014025:Titanium / Q000032:analysis / Q000737:chemistry*
chemical_list: D000497:Alloys; D000538:Aluminum Silicates; D001031:Apatites; D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; C031462:titanium alloy (TiAl6V4); C049037:aluminosilicate; D014025:Titanium; C025105:fluorapatite