title: Decrease in NF-kappaB, AP-1 and SP-1 activities in neuronal cells expressing presenilin 2.
abstract: Decreases in activities of the NF-kappaB, AP-1 and SP-1 transcription factors, which could act as antiapoptotic factors, in the presenilin 2 transfected PC12 cells, either in nontreatment conditions or under apoptotic stimulation, were found in this study. Similar results were also found in mice brain cells carrying presenilin 2, especially in the mutant gene expressed ones. These findings suggested that presenilin 2 may be implicated in neuronal cell death by altering the antiapoptotic activity of the transcription factors.
authors.affiliation: College of Pharmacy, Chungbuk National University, Chungbuk 361-763, Korea.
authors.forename: Hong Nga
authors.initials: HN
authors.lastname: Nguyen
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Dae Youn
authors.initials: DY
authors.lastname: Hwang
authors.forename: Yong Kyu
authors.initials: YK
authors.lastname: Kim
authors.forename: Dong Yeon
authors.initials: DY
authors.lastname: Yuk
authors.forename: Jun Seup
authors.initials: JS
authors.lastname: Lee
authors.forename: Jin Tae
authors.initials: JT
authors.lastname: Hong
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism; D016923:Cell Death / Q000502:physiology; D015870:Gene Expression; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D016328:NF-kappa B / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D016716:PC12 Cells; D053766:Presenilin-2; D051381:Rats; D016329:Sp1 Transcription Factor / Q000378:metabolism*; D018808:Transcription Factor AP-1 / Q000378:metabolism*
chemical_list: D008565:Membrane Proteins; D016328:NF-kappa B; D053766:Presenilin-2; D016329:Sp1 Transcription Factor; D018808:Transcription Factor AP-1