title: Phytosterols in nonfat and low-fat beverages have no impact on the LDL size phenotype.
abstract: OBJECTIVE
  To examine the impact of nonfat and low-fat phytosterol-enriched beverages on low-density lipoprotein (LDL) electrophoretic characteristics.
  
  
  METHODS
  Double-blind, randomized, crossover, placebo-controlled dietary trial.
  
  
  METHODS
  Diets were prepared and consumed at the Mary Emily Clinical Nutrition Research Unit of McGill University. Analyses were performed at the Institute on Nutraceuticals and Functional Foods of Laval University.
  
  
  METHODS
  In total, 15 moderately hypercholesterolemic persons consumed each of three experimental diets that each comprised a different beverage: nonfat placebo (NF control), nonfat with phytosterols (NFPS) or low-fat with phytosterols (LFPS). Participants consumed three beverages daily at meal time for a total of 1.8 g of phytosterols per day. Nondenaturing 2-16% polyacrylamide gradient gel electrophoreses were used to characterize LDL size characteristics.
  
  
  RESULTS
  The NFPS and LFPS beverage induced no significant changes in several features of the LDL size phenotype compared to the control diet.
  
  
  CONCLUSIONS
  The consumption of phytosterol-supplemented nonfat and low-fat beverages is not associated with clinically meaningful changes in the LDL particle size phenotype.
authors.affiliation: Institute on Nutraceuticals and Functional Foods, Laval University, Québec, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Charest
authors.forename: C
authors.initials: C
authors.lastname: Vanstone
authors.forename: M P
authors.initials: MP
authors.lastname: St-Onge
authors.forename: W
authors.initials: W
authors.lastname: Parson
authors.forename: P J H
authors.initials: PJ
authors.lastname: Jones
authors.forename: B
authors.initials: B
authors.lastname: Lamarche
mesh_terms: D000328:Adult; D000368:Aged; D001628:Beverages; D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects*; D018592:Cross-Over Studies; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D058870:Food, Organic; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D010641:Phenotype; D010840:Phytosterols / Q000008:administration & dosage / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004041:Dietary Fats; D010840:Phytosterols; D014280:Triglycerides