title: Domino liver transplantation in living donors.
abstract: Domino liver transplantation (DLT) has been developed as a method to expand the donor pool. In living donors DLT, the prime concern is to avoid any disadvantage to the donor and the first recipient. Seven DLTs were performed among 211 patients who underwent living donor liver transplantation. The domino recipients included six with hepatocellular carcinoma and one with citrullinemia. The domino grafts were obtained from patients with familial amyloid polyneuropathy (FAP) including the left liver in three cases and the right liver in four. Among the seven domino recipients, a 64-year-old woman with advanced hepatocellular carcinoma died of lung metastasis. The other six domino recipients are alive without FAP symptoms. In living donor liver transplantation, because the vessels of the graft from the first donor are not long enough for anastomosis, the hepatic vessels must be left as long as possible when removing the liver from the FAP patients in order to ensure sufficient safety for vascular reconstruction. With careful decision making during the procedure, such as where to divide the vessels in the FAP patients, DLT may help address the shortage of liver grafts.
authors.affiliation: Division of Transplantation, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan. yh@hsp.md.shinshu-u.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Hashikura
authors.forename: T
authors.initials: T
authors.lastname: Ikegami
authors.forename: Y
authors.initials: Y
authors.lastname: Nakazawa
authors.forename: K
authors.initials: K
authors.lastname: Urata
authors.forename: M
authors.initials: M
authors.lastname: Mihara
authors.forename: A
authors.initials: A
authors.lastname: Mita
authors.forename: M
authors.initials: M
authors.lastname: Sakon
authors.forename: S
authors.initials: S
authors.lastname: Miyagawa
authors.forename: S
authors.initials: S
authors.lastname: Ikeda
mesh_terms: D028227:Amyloid Neuropathies, Familial / Q000601:surgery; D000714:Anastomosis, Surgical / Q000379:methods*; D006528:Carcinoma, Hepatocellular / Q000601:surgery; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D006499:Hepatic Artery / Q000601:surgery; D006503:Hepatic Veins / Q000601:surgery; D006801:Humans; D008113:Liver Neoplasms / Q000601:surgery; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors / Q000600:supply & distribution; D008875:Middle Aged; D020858:Tissue and Organ Harvesting / Q000379:methods*