Emerging role of the FGF system in psychiatric disorders.
Fibroblast growth factors (FGFs) comprise several peptides that, by interacting with a family of FGF receptors, participate in brain development and contribute to neuronal repair and plasticity. Recent evidence suggests that the expression of FGFs is altered in mood disorders and can be regulated by psychotropic drugs. This provides further support to the notion that neurotrophic molecules might have a role in the etiology and treatment of mental disorders.
Riva
Marco A
MA
Center of Neuropharmacology and Center of Excellence on Neurodegenerative Diseases, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy. M.Riva@unimi.it
Molteni
Raffaella
R
Bedogni
Francesco
F
Racagni
Giorgio
G
Fumagalli
Fabio
F
D005346:Fibroblast Growth Factors / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D001523:Mental Disorders / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D009154:Mutation; D009473:Neuronal Plasticity / Q000187:drug effects; D011619:Psychotropic Drugs / Q000494:pharmacology* / Q000627:therapeutic use
D008024:Ligands; D011619:Psychotropic Drugs; D005346:Fibroblast Growth Factors