title: [Expression of brain-derived neurotrophic factor in hippocampus of ovariectomized mouse].
abstract: OBJECTIVE
  To explore the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus after ovariectomy in mice.
  
  
  METHODS
  BDNF levels were detected by immunohistochemistry combined image analysis in hippocampal CA regions and dentate gyrus of ovariectomized mice.
  
  
  RESULTS
  The expression of BDNF in hippocampus of mice decreased significantly after the ovariectomy after 4 days. The recovery BDNF expression started 14 days after the ovariectomy and after 28 days, the expression of BDNF in hippocampus recovered to the normal level.
  
  
  CONCLUSIONS
  The decrease of estrogen in ovariectomized mice can weaken the expression of BDNF in hippocampus during the early stage.
authors.affiliation: Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha 410013, China.
authors.forename: Da-hua
authors.initials: DH
authors.lastname: Lu
authors.forename: De-sen
authors.initials: DS
authors.lastname: Yang
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.forename: Chang-qi
authors.initials: CQ
authors.lastname: Li
authors.forename: Xue-gang
authors.initials: XG
authors.lastname: Luo
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000096:biosynthesis* / Q000235:genetics; D018891:Dentate Gyrus / Q000378:metabolism; D004967:Estrogens / Q000097:blood; D005260:Female; D006624:Hippocampus / Q000378:metabolism*; D051379:Mice; D010052:Ovariectomy; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D004967:Estrogens; D012333:RNA, Messenger