Susceptibility of bovine mesenchymal stem cells to bovine herpesvirus 4.
Bovine herpesvirus 4 (BoHV-4) is a gamma herpesvirus with no clear disease association. Previous studies have demonstrated that macrophages can harbour persistent BoHV-4. Since mesenchymal stem cells in bone marrow regulate the differentiation and proliferation of adjacent haematopoietic precursors, such as macrophages, the interaction between BoHV-4 and mesenchymal stem cells was investigated. Primary bovine mesenchymal stem cells were highly permissive to support full replication of BoHV-4. This finding could be considered a new important step in studies on the potential pathogenesis related to BoHV-4.
Donofrio
G
G
Dipartimento di Salute Animale, Sezione di Malattie Infettive degli Animali, Facoltà di Medicina Veterinaria, Via del Taglio 8, 43100 Parma, Italy. donofrio@unipr.it
Colleoni
S
S
Galli
C
C
Lazzari
G
G
Cavirani
S
S
Flammini
C F
CF
D000818:Animals; D001854:Bone Marrow Cells / Q000821:virology; D002478:Cells, Cultured; D004198:Disease Susceptibility; D006566:Herpesviridae Infections / Q000473:pathology; D026021:Herpesvirus 4, Bovine / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D059630:Mesenchymal Stem Cells / Q000821:virology*