title: Synthesis of novel 10-deoxoartemisinins.
abstract: The synthesis of novel 10-deoxoartemisinin derivatives containing heterocyclic rings and hydrophilic groups, and their antimalarial activity assessment are described. Most of the synthesized derivatives are more potent than artemisinin, especially, some of them are 20-25 times more potent than artemisinin to two chloroquine-resistant and sensitive clones of P. falciparum.
authors.affiliation: Institute of Chemistry, Vietnamese Academy of Science and Technology, 18-Hoang Quoc Viet Road, Cau Giay District, Hanoi, Viet Nam. tkvu@ich.ncst.ac.vn
authors.forename: Vu Tran
authors.initials: VT
authors.lastname: Khac
authors.forename: Tuyen Nguyen
authors.initials: TN
authors.lastname: Van
authors.forename: Sung Tran
authors.initials: ST
authors.lastname: Van
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology; D037621:Artemisinins / Q000138:chemical synthesis* / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects
chemical_list: D000962:Antimalarials; D037621:Artemisinins