title: Identification of chemokine receptor CCR4 antagonist.
abstract: The present study reports the identification and hits to leads optimization of chemokine receptor CCR4 antagonists. Compound 12 is a high affinity, non-cytotoxic antagonist of CCR4 that blocks the functional activity mediated by the receptor.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543, USA. ashok.purandare@bms.com
authors.forename: Ashok V
authors.initials: AV
authors.lastname: Purandare
authors.forename: Aiming
authors.initials: A
authors.lastname: Gao
authors.forename: Honghe
authors.initials: H
authors.lastname: Wan
authors.forename: John
authors.initials: J
authors.lastname: Somerville
authors.forename: Christine
authors.initials: C
authors.lastname: Burke
authors.forename: Carrie
authors.initials: C
authors.lastname: Seachord
authors.forename: Wayne
authors.initials: W
authors.lastname: Vaccaro
authors.forename: John
authors.initials: J
authors.lastname: Wityak
authors.forename: Michael A
authors.initials: MA
authors.lastname: Poss
mesh_terms: D054398:Receptors, CCR4; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors* / Q000502:physiology; D013329:Structure-Activity Relationship
chemical_list: D054398:Receptors, CCR4; D019707:Receptors, Chemokine