title: Biomarkers for the detection and prognosis of prostate cancer.
abstract: Recent studies have cast doubt on the reliability of serum total prostate-specific antigen as a biomarker for the detection and prognosis of prostate cancer. Biomarkers that can identify those men at risk for clinically significant prostate cancer are desperately needed. The search for biomarkers that may improve the detection of biologically consequential prostate cancer is one of the most active areas under current investigation. In this review, we highlight some of these ongoing efforts. Proper validation of newly discovered biomarkers is of paramount importance.
authors.affiliation: Department of Urology, University of Texas Health Sciences Center, A7703, Floyd Curl Drive, San Antonio, TX 78229, USA. hernandezj7@uthscsa.edu
authors.forename: Javier
authors.initials: J
authors.lastname: Hernandez
authors.forename: Edith
authors.initials: E
authors.lastname: Canby-Hagino
authors.forename: Ian M
authors.initials: IM
authors.lastname: Thompson
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D005819:Genetic Markers; D006801:Humans; D008297:Male; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D020033:Protein Isoforms / Q000097:blood; D040901:Proteomics / Q000379:methods; D019998:Racemases and Epimerases / Q000652:urine
chemical_list: D014408:Biomarkers, Tumor; D005819:Genetic Markers; D020033:Protein Isoforms; D017430:Prostate-Specific Antigen; D019998:Racemases and Epimerases; C108352:alpha-methylacyl-CoA racemase