Reversible insulin self-assembly under carbohydrate control.
Insulin with built-in pairs of boronates and polyols can produce soluble high molecular weight self-assemblies under control by carbohydrates. The illustrated principle has potential utility for general protein and peptide protraction and controlled drug release.
Hoeg-Jensen
Thomas
T
Novo Nordisk, Novo Alle 6B2.54, DK-2880 Bagsvaerd, Denmark. tshj@novonordisk.com
Havelund
Svend
S
Nielsen
Peter K
PK
Markussen
Jan
J
D000595:Amino Acid Sequence; D001897:Boronic Acids / Q000737:chemistry; D002850:Chromatography, Gel; D005947:Glucose / Q000737:chemistry*; D007328:Insulin / Q000737:chemistry*; D007700:Kinetics; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011972:Receptor, Insulin / Q000737:chemistry; D013012:Sorbitol / Q000737:chemistry*
D001897:Boronic Acids; D007328:Insulin; D013012:Sorbitol; D011972:Receptor, Insulin; D005947:Glucose