title: Synthesis and characterisation of novel nanospheres made from amphiphilic perfluoroalkylthio-beta-cyclodextrins.
abstract: This work describes the synthesis of new amphiphilic perfluorohexyl- and perfluorooctyl-propanethio-beta-cyclodextrins and the comparison of the ability of these molecules and alkyl analogue, nonanethio-beta-cyclodextrin to form nanospheres. Nanospheres were prepared using nanoprecipitation method (perfluoroalkylthio-beta-cyclodextrin in THF [0.11 x 10(-3)M], stirring rate 700rpm, addition of aqueous phase at 64 degrees C into organic phase at 50 degrees C). They were characterised by Photon Correlation Spectroscopy (PCS) and by electron microscopy (SEM and cryo-TEM). The nanospheres prepared from these new beta-cyclodextrin derivatives have an average size of 260nm, and appear to be spherical in cryo-TEM images. Whereas alkyl analogue forms polydisperse aggregates with sizes in the range 60-350nm.
authors.affiliation: Université Claude Bernard Lyon 1, Laboratoire de Méthodologie de Synthèse et Molécules Bioactives, Villeurbanne Cedex, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Péroche
authors.forename: Ghania
authors.initials: G
authors.lastname: Degobert
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Putaux
authors.forename: Marie-Geneviève
authors.initials: MG
authors.lastname: Blanchin
authors.forename: Hatem
authors.initials: H
authors.lastname: Fessi
authors.forename: Hélène
authors.initials: H
authors.lastname: Parrot-Lopez
mesh_terms: D000478:Alkylation; D020285:Cryoelectron Microscopy; D004355:Drug Stability; D005079:Excipients; D005612:Freeze Drying; D009682:Magnetic Resonance Spectroscopy; D008863:Microspheres; D010316:Particle Size; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D005079:Excipients; D047392:beta-Cyclodextrins