High-resolution 3D scaffold model for engineered tissue fabrication using a rapid prototyping technique.
Rapid prototyping, automatic image processing (computer-aided design (CAD)) and computer-aided manufacturing techniques are opening new and interesting prospects for medical devices and tissue engineering, especially for hard tissues such as bone. The development of a bone high-resolution scaffold prototype using these techniques is described. The results testify to the fidelity existing between microtomographic reconstruction and CAD. Furthermore, stereolithographic manufacturing of this scaffold, which possesses a high degree of similarity to the starting model as monitored by morphological evaluations (mean diameter 569 +/- 147 microm), represents a promising result for regenerative medicine applications.
Quadrani
P
P
Consorzio Interuniversitario CINECA, Bologna, Italy.
Pasini
A
A
Mattiolli-Belmonte
M
M
Zannoni
C
C
Tampieri
A
A
Landi
E
E
Giantomassi
F
F
Natali
Casali
F
F
Biagini
G
G
Tomei-Minardi
A
A
D018786:Bone Substitutes; D017076:Computer-Aided Design; D017886:Durapatite; D020342:Finite Element Analysis; D006801:Humans; D023822:Tissue Engineering / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods
D018786:Bone Substitutes; D017886:Durapatite