Trans-4-aminocrotonic acid (TACA), a potent agonist of GABA(A) and GABA(C) receptors, shows a proconvulsant action in the electroconvulsive threshold test in mice.
In the present study, we evaluated TACA (a potent agonist of GABA(A) and GABA(C) receptors) in the electroconvulsive threshold test in mice. Surprisingly, TACA (at 15 and 25 mg/kg) significantly decreased the threshold. The highest ineffective dose of TACA was estimated as 10 mg/kg. The obtained results indicate that the drug enhancing GABAergic transmission may possess proconvulsant properties in the electroconvulsive test. Such effect was completely opposite to our primary assumption and expectance.
Borowicz
Kinga K
KK
Department of Pathophysiology, Skubiszewski Medical University, Jaczewskiego 8, PL 20-090 Lublin, Poland. kornel@asklepios.am.lublin.pl
Zadrozniak
Marek
M
Czuczwar
Stanisław J
SJ
D000818:Animals; D003437:Crotonates / Q000633:toxicity; D004597:Electroshock; D018755:GABA Agonists / Q000494:pharmacology*; D008297:Male; D051379:Mice; D012640:Seizures / Q000139:chemically induced*
D003437:Crotonates; D018755:GABA Agonists; C055331:4-aminocrotonic acid