title: Somatostatin-producing pancreatic endocrine carcinoma presented as relapsing cholangitis -- a case report.
abstract: Somatostatin-producing endocrine tumors are rare neoplasms usually arising in the pancreas and duodenum and they account for less than 1% of all gastrointestinal endocrine tumors. Besides somatostatinoma syndrome, which is characterized by diabetes mellitus, steatorrhea and cholelithiasis, patients with somatostatin-producing endocrine tumors commonly complain of nonspecific symptoms such as vague abdominal pain, weight loss or changes in bowel habits. Tumor behavior cannot be predicted by histological features alone, and malignancy is determined by the presence of metastases. We report here a case of malignant pancreatic endocrine tumor producing somatostatin presented as relapsing cholangitis who was treated with Whipple pancreatoduodenectomy.
authors.affiliation: Second Propedeutical Department of Surgery, Aristotelian University of Thessaloniki, Thessaloniki, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Marakis
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Ballas
authors.forename: Savas
authors.initials: S
authors.lastname: Rafailidis
authors.forename: Michael
authors.initials: M
authors.lastname: Alatsakis
authors.forename: Kalliopi
authors.initials: K
authors.lastname: Patsiaoura
authors.forename: Athanassios
authors.initials: A
authors.lastname: Sakadamis
mesh_terms: D002761:Cholangitis / Q000175:diagnosis*; D003937:Diagnosis, Differential; D006801:Humans; D007515:Islets of Langerhans / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D012008:Recurrence; D013004:Somatostatin / Q000378:metabolism; D013005:Somatostatinoma / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery
chemical_list: D013004:Somatostatin