Decrease in NF-kappaB, AP-1 and SP-1 activities in neuronal cells expressing presenilin 2.
Decreases in activities of the NF-kappaB, AP-1 and SP-1 transcription factors, which could act as antiapoptotic factors, in the presenilin 2 transfected PC12 cells, either in nontreatment conditions or under apoptotic stimulation, were found in this study. Similar results were also found in mice brain cells carrying presenilin 2, especially in the mutant gene expressed ones. These findings suggested that presenilin 2 may be implicated in neuronal cell death by altering the antiapoptotic activity of the transcription factors.
Nguyen
Hong Nga
HN
College of Pharmacy, Chungbuk National University, Chungbuk 361-763, Korea.
Lee
Sun Young
SY
Hwang
Dae Youn
DY
Kim
Yong Kyu
YK
Yuk
Dong Yeon
DY
Lee
Jun Seup
JS
Hong
Jin Tae
JT
D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism; D016923:Cell Death / Q000502:physiology; D015870:Gene Expression; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D016328:NF-kappa B / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D016716:PC12 Cells; D053766:Presenilin-2; D051381:Rats; D016329:Sp1 Transcription Factor / Q000378:metabolism*; D018808:Transcription Factor AP-1 / Q000378:metabolism*
D008565:Membrane Proteins; D016328:NF-kappa B; D053766:Presenilin-2; D016329:Sp1 Transcription Factor; D018808:Transcription Factor AP-1