Difructose anhydrides III and IV equally promote calcium absorption from the luminally perfused rat small intestine.
We examined the effects of di-D-fructose anhydride (DFA) III and IV on Ca absorption in luminally perfused segments of the small intestine in anesthetized rats. The calcium absorption rate with perfusion of 10 mmol/l CaCl2 was similarly increased by addition of 100 mmol/l DFAIII or IV, and these promotive effects of both DFAs were pronounced at perfusion rate of 0.15 ml/min than at 0.3 ml/min. The promotive effects were higher in the duodenojejunum than in the ileum.
Hara
Hiroshi
H
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan. hara@chem.agr.hokudai.ac.jp
Kondo
Kazuma
K
D000818:Animals; D002118:Calcium / Q000378:metabolism* / Q000493:pharmacokinetics; D004187:Disaccharides / Q000494:pharmacology*; D007408:Intestinal Absorption / Q000187:drug effects*; D007421:Intestine, Small / Q000187:drug effects* / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D010477:Perfusion; D051381:Rats; D017207:Rats, Sprague-Dawley
D004187:Disaccharides; C033869:difructose anhydride IV; C087758:difructose anhydride III; D002118:Calcium