title: 6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid mimics active conformation of tyrosine in opioid peptides.
abstract: 6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (6Htc) has been proposed as a rigid mimic of tyrosine conformation in opioid ligand-receptor complex. The significant receptor binding to mu and delta opioid receptors of respective analogues of deltorphin, dermorphin, and endomorphin with D,L-6Htc prove initial prediction.
authors.affiliation: Department of Pharmaceutical Sciences, University of Catania, Catania 95125, Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Sperlinga
authors.forename: Piotr
authors.initials: P
authors.lastname: Kosson
authors.forename: Zofia
authors.initials: Z
authors.lastname: Urbanczyk-Lipkowska
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ronsisvalle
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Carr
authors.forename: Andrzej W
authors.initials: AW
authors.lastname: Lipkowski
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D018360:Crystallography, X-Ray; D007546:Isoquinolines / Q000737:chemistry*; D015394:Molecular Structure; D018847:Opioid Peptides / Q000737:chemistry*; D011957:Receptors, Opioid / Q000737:chemistry; D014443:Tyrosine / Q000737:chemistry*
chemical_list: D002264:Carboxylic Acids; D007546:Isoquinolines; D018847:Opioid Peptides; D011957:Receptors, Opioid; D014443:Tyrosine