title: Prognostic significance of syndecan-1 expression in human endometrial cancer.
abstract: BACKGROUND
  Syndecan-1 binds to various extracellular matrix components via its heparan sulfate glycosaminoglycans. The aim of this study was to investigate syndecan-1 expression in endometrial cancers.
  
  
  METHODS
  We investigated the expression of the syndecan-1 core protein by immunohistochemistry in 109 endometrial cancers, and analyzed correlation with various clinicopathological features, including patient outcome.
  
  
  RESULTS
  Epithelial syndecan-1 expression was significantly lower in advanced stage, high grade, deep myometrial invasion, cervical involvement, lymph node metastasis, lymph vascular space involvement and positive peritoneal cytology. Stromal syndecan-1 expression was significantly higher in high-grade tumors. The disease-free and overall survival rates of patients exhibiting both low epithelial and high stromal syndecan-1 expression was poor. Multivariate analysis showed that high stromal syndecan-1 expression was an independent prognostic factor for both disease-free and overall survival. Low epithelial syndecan-1 expression was a prognostic factor only in the univariate analysis.
  
  
  CONCLUSIONS
  Loss of epithelial syndecan-1 and induction of stromal syndecan-1 expression may be associated with tumor progression. Stromal syndecan-1 expression can serve as an indicator of poor prognosis in patients with endometrial cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan.
authors.lastname: Hasengaowa
authors.forename: J
authors.initials: J
authors.lastname: Kodama
authors.forename: T
authors.initials: T
authors.lastname: Kusumoto
authors.forename: Y
authors.initials: Y
authors.lastname: Shinyo
authors.forename: N
authors.initials: N
authors.lastname: Seki
authors.forename: Y
authors.initials: Y
authors.lastname: Hiramatsu
mesh_terms: D016889:Endometrial Neoplasms / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008875:Middle Aged; D011379:Prognosis; D011509:Proteoglycans / Q000378:metabolism*; D017154:Stromal Cells / Q000378:metabolism; D016019:Survival Analysis; D053668:Syndecan-1; D053667:Syndecans
chemical_list: D008562:Membrane Glycoproteins; D011509:Proteoglycans; C508241:SDC1 protein, human; D053668:Syndecan-1; D053667:Syndecans