Circadian rhythm of acute phase proteins under the influence of bright/dim light during the daytime.
We investigated the influence of two different light intensities, dim (100 lx) and bright (5000 lx), during the daytime on the circadian rhythms of selected acute phase proteins of C-reactive protein (CRP), alpha1-acid glycoprotein (AGP), alpha1-antichymotrypsin (ACT), transfferin (TF), alpha2-macroglobulin (alpha2-m), haptoglobin (HP), and ceruloplasmin (CP). Serum samples were collected from 7 healthy volunteers at 4 h intervals during two separate single 24 h spans during which they were exposed to the respective light intensity conditions. A circadian rhythm was detected only in ACT concentration in the bright light condition. The concentration of ACT, a positive acute phase protein (APP), increased (significantly significant differences in the ACT concentration were detected at 14:00 and 22:00 h) and AGP showed a tendency to be higher under the daytime bright compared to dim light conditions. There were no significant differences between the time point means under daytime dim and bright light conditions for alpha2-M, AGP, Tf, Cp, or Hp. The findings suggest that some, but not all, APP may be influenced by the environmental light intensity.
Kanikowska
Dominika
D
Department of Environmental Health, Nara Women's University, Nara, Japan. dkanikowska@hotmail.com
Hyun
Ki-Ja
KJ
Tokura
Hiromi
H
Azama
Takashi
T
Nishimura
Shinya
S
D000209:Acute-Phase Proteins / Q000096:biosynthesis / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D002097:C-Reactive Protein / Q000096:biosynthesis; D002570:Ceruloplasmin / Q000096:biosynthesis; D002940:Circadian Rhythm; D005260:Female; D006242:Haptoglobins / Q000096:biosynthesis; D006801:Humans; D008027:Light; D008597:Menstrual Cycle; D009961:Orosomucoid / Q000096:biosynthesis; D017440:Photoperiod; D010865:Pilot Projects; D013997:Time Factors; D014168:Transferrin / Q000096:biosynthesis; D000514:alpha 1-Antichymotrypsin / Q000096:biosynthesis / Q000097:blood; D000511:alpha-Macroglobulins / Q000096:biosynthesis
D000209:Acute-Phase Proteins; D006242:Haptoglobins; D009961:Orosomucoid; D014168:Transferrin; D000514:alpha 1-Antichymotrypsin; D000511:alpha-Macroglobulins; D002097:C-Reactive Protein; D002570:Ceruloplasmin