Synthesis of novel 10-deoxoartemisinins.
The synthesis of novel 10-deoxoartemisinin derivatives containing heterocyclic rings and hydrophilic groups, and their antimalarial activity assessment are described. Most of the synthesized derivatives are more potent than artemisinin, especially, some of them are 20-25 times more potent than artemisinin to two chloroquine-resistant and sensitive clones of P. falciparum.
Khac
Vu Tran
VT
Institute of Chemistry, Vietnamese Academy of Science and Technology, 18-Hoang Quoc Viet Road, Cau Giay District, Hanoi, Viet Nam. tkvu@ich.ncst.ac.vn
Van
Tuyen Nguyen
TN
Van
Sung Tran
ST
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology; D037621:Artemisinins / Q000138:chemical synthesis* / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects
D000962:Antimalarials; D037621:Artemisinins