Burkitt-type acute leukemia in a patient with B-prolymphocytic leukemia: evidence for a common origin.
Burkitt-type acute leukemia cells were present in the bone marrow of a patient with B-prolymphocytic leukemia diagnosed from peripheral blood cell morphology. Immunophenotype analysis confirmed morphological patterns. Cytogenetic and fluorescence in situ hybridization (FISH) analysis showed an identical t(8;22)(q24;q21) with MYC locus rearrangement in blood and bone marrow cells, with additional chromosome abnormalities in the bone marrow. In addition, the loss of one copy of the TP53 gene and identical IGH DNA clonal rearrangements were shown with FISH and polymerase chain reaction analysis respectively in the two types of leukemic cells. These data indicated the common origin of the two coexisting leukemias and are the first example of such occurrence in a leukemic patient.
Nguyen-Khac
Florence
F
Service d'Hématologie Biologique, Groupe Hospitalier Pitié-Salpêtrière, Paris, France. florence.nguyen@psl.ap-hop-paris.fr
Davi
Frédéric
F
Receveur
Aline
A
Maloum
Karim
K
Morel
Véronique
V
Le Garff-Tavernier
Magali
M
Ong
Jeanne
J
Berger
Roland
R
Leblond
Véronique
V
Merle-Béral
Hélène
H
D001853:Bone Marrow / Q000473:pathology; D002051:Burkitt Lymphoma / Q000235:genetics* / Q000473:pathology; D019070:Cell Lineage; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D020732:Cytogenetic Analysis; D005260:Female; D015321:Gene Rearrangement; D016259:Genes, myc; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015463:Leukemia, Prolymphocytic / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic