title: Spontaneous remission of primary diffuse large B-cell gastric lymphoma.
abstract: Spontaneous and complete disappearance of diffuse large B-cell lymphoma (DLBL) of the stomach is extremely rare. Although regression of gastric DLBL after eradication of Helicobacter pylori has recently been reported, we present two consecutive cases of stage I DLBL of the stomach which disappeared after only nonspecific therapy, including histamine 2-receptor antagonist (H2RA); both cases were documented histologically and endoscopically. Both patients were positive for H. pylori, and later received H. pylori eradication therapy. The disease has not recurred after 11 and 6 months, respectively. Our cases suggest that the option of combination therapy with H2RA either with or followed by H. pylori eradication is appropriate for consideration as an initial approach in standard therapy for stage I diffuse large B-cell gastric lymphoma.
authors.affiliation: Third Department of Internal Medicine, Asahikawa Medical College, 2-1-1-1 Midorigaoka-Higashi, Asahikawa 078-8510, Japan.
authors.forename: Jiro
authors.initials: J
authors.lastname: Watari
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Saitoh
authors.forename: Mikihiro
authors.initials: M
authors.lastname: Fujiya
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Nakamura
authors.forename: Yuhei
authors.initials: Y
authors.lastname: Inaba
authors.forename: Kotaro
authors.initials: K
authors.lastname: Okamoto
authors.forename: Hiroki
authors.initials: H
authors.lastname: Tanabe
authors.forename: Atsumi
authors.initials: A
authors.lastname: Yasuda
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Miyokawa
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kohgo
mesh_terms: D001706:Biopsy; D019160:Endosonography; D005260:Female; D005500:Follow-Up Studies; D005773:Gastroscopy; D006801:Humans; D016393:Lymphoma, B-Cell / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009365:Neoplasm Regression, Spontaneous; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed