Chondrosarcoma, lupus anticoagulant and cerebral ischaemia.
Chondrosarcoma is a malignant disease of cartilage. Systemic embolisation usually arises from cancerous invasion of pulmonary vessels or the left atrium but cerebral embolisation or ischaemia is rarely recognised. We report a man with left leg amputation for tibial myxoid chondrosarcoma who suffered multiple cerebral embolisms one year later. Cerebral angiography and aortogram did not reveal luminal stenosis and a cardiac survey was normal. Lupus anticoagulant (LAC) and a prolonged activated partial thromboplastin time were detected. A molecular mimicry between prothrombin and paracrine hormones may have accounted for his LAC. A procoagulant autoantibody reacting against metastatic cancer cells may contribute to cancerous thrombosis, such as in chondrosarcoma.
Chen
Wei Hsi
WH
Stroke Biology Research Laboratory, Department of Neurology, Chang Gung Memorial Hospital, Niao Sung Hsiang, Kaohsiung, Taiwan.
Liu
Jia Shou
JS
D000671:Amputation, Surgical; D001859:Bone Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D002545:Brain Ischemia / Q000209:etiology / Q000473:pathology*; D002533:Cerebral Angiography; D002813:Chondrosarcoma / Q000150:complications / Q000473:pathology* / Q000601:surgery; D006801:Humans; D020766:Intracranial Embolism / Q000209:etiology; D007866:Leg / Q000601:surgery; D016682:Lupus Coagulation Inhibitor / Q000097:blood*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D013977:Tibia
D016682:Lupus Coagulation Inhibitor