title: Safety and efficacy of outpatient gamma knife radiosurgery for multiple cerebral metastases.
abstract: This review highlights the experience of a single institution using the Leksell gamma knife for 8 years. More than 500 patients with multiple cerebral metastases received outpatient radiosurgery. The results prove that there is a high efficacy and attractively low morbidity of modern outpatient radiosurgery. When compared with whole brain radiation therapy, radiosurgery improved survival in patients with cerebral metastases. Most importantly, the number of brain metastases had no prognostic impact in patients with non-small cell lung cancer, renal cell cancer, malignant melanoma and gastrointestinal cancer.
authors.affiliation: Gamma Knife Center, Ingolstädter Str. 166, D 80939 München, Germany. wowra@gammaknife.de
authors.forename: Berndt
authors.initials: B
authors.lastname: Wowra
authors.forename: Alexander
authors.initials: A
authors.lastname: Muacevic
authors.forename: Anja
authors.initials: A
authors.lastname: Jess-Hempen
authors.forename: Jörg-Christian
authors.initials: JC
authors.lastname: Tonn
mesh_terms: D000553:Ambulatory Care / Q000379:methods*; D001932:Brain Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D006801:Humans; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods*; D015996:Survival Rate