Hematological and serum biochemical values in cynomolgus monkeys anesthetized with ketamine hydrochloride.
The effects of ketamine anesthesia on both hematological and serum biochemical variables were investigated in 19 male and 15 female cynomolgus monkeys. Blood samples were obtained from the cephalic vein within 30 minutes of an intramuscular injection of ketamine hydrochloride (10 mg/kg). Ketamine anesthesia caused a reduction in leukocyte counts and a significant reduction in lymphocytes percentages. Ketamine anesthesia also increased the serum activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and creatine phosphokinase (CPK), but reduced the serum concentrations of glucose, inorganic phosphate, sodium and potassium. The alterations of hematological and serum biochemical values will be discussed. These alterations should be considered when designing studies for and interpreting data from cynomolgus monkeys.
Kim
Choong-Yong
CY
Nonhuman Primate Team, Toxicology Division, Korea Institute of Toxicology, KRICT, Yuseong, Daejeon, Korea.
Lee
Hyun-Sook
HS
Han
Su-Cheol
SC
Heo
Jeong-Doo
JD
Kwon
Myung-Sang
MS
Ha
Chang-Su
CS
Han
Sang-Seop
SS
D000410:Alanine Transaminase / Q000097:blood; D000758:Anesthesia / Q000662:veterinary*; D000778:Anesthetics, Dissociative / Q000009:adverse effects*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D007649:Ketamine / Q000009:adverse effects*; D007958:Leukocyte Count; D018655:Lymphocyte Count; D008252:Macaca fascicularis / Q000097:blood*; D008297:Male; D010710:Phosphates / Q000097:blood; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood
D000778:Anesthetics, Dissociative; D001786:Blood Glucose; D010710:Phosphates; D007649:Ketamine; D012964:Sodium; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase; D011188:Potassium