[Observation of the effect of BCG-SPN in FESS perioperative period].
OBJECTIVE
To observe the therapeutic effect of BCG-SPN and corticosteroid in endoscopic perioperative period of chronic rhinitis (CH) and nasal polyps (NP) combined with allergic rhinitis (AR) or asthma, and to inquire their immune mechanism and find new therapeutic approach.


METHODS
Ninety-six patients diagnosed of CH and NP combined with AR or asthma were randomly divided into 3 groups. Group 1 was given 1ml of BCG-SPN intramuscular injection once every two days;group 2 was used corticosteroid nasal spray once a day; group III was given those two kinds of preparations as above, all for 5 weeks. The morphologic transformation of nasal mucosa was observed under endoscope within 6 months.


RESULTS
The rates of efficiency were as follow: group 1 70.97%, 2 73.33%, 3 90.63%. Statistically, the difference between group 1 and 2 was insignificant; while, the difference between group 3 and each of above was significant.


CONCLUSIONS
BCG-SPN and corticosteroid nasal spray were both effective in nasal mucosa transformation in FESS postoperation for patients with allergic CH and NP; moreover, combined usages were better. The mechanism may be that the balance of Th1 and Th2 cell subgroup was modulated by different ways, so as to prevent allergic effect. Combined therapy provides new approach to deal with these kinds of patients.
Shi
Guanggang
G
Department of Otorhinolaryngology, Shandong Province Hospital, Jinan, 250021, China. 7036285@163.com
He
Mingqiang
M
Liu
Yiqing
Y
Li
Xiuguo
X
D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000188:drug therapy* / Q000601:surgery; D001500:BCG Vaccine / Q000008:administration & dosage*; D002908:Chronic Disease; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D009711:Nucleotides / Q000008:administration & dosage; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy* / Q000601:surgery; D012852:Sinusitis / Q000150:complications / Q000188:drug therapy* / Q000601:surgery
D001500:BCG Vaccine; D005938:Glucocorticoids; D009711:Nucleotides; D011135:Polysaccharides, Bacterial