title: Effects of surgery on the acute phase response in clinically normal and diseased horses.
abstract: The serum concentrations of serum amyloid A, haptoglobin and fibrinogen were measured in a group of horses before and at intervals after elective and non-elective surgery, and in a control group of normal horses. There was a significant, rapid and repeatable increase in the concentration of serum amyloid A in response to both elective and non-elective surgery. In the control horses its serum concentration was within the normal range, from 0 to 0.2 microg/ml. Twenty-four hours after elective surgery its mean peak concentration was 16.4 microg/ml, and after non-elective surgery it was 27.3 microg/ml. In contrast, the serum concentrations of haptoglobin and fibrinogen increased more slowly after surgery and had not decreased by 72 hours after surgery.
authors.affiliation: Department of Veterinary Surgery, Faculty of Veterinary Medicine, University College Dublin, Belfield, Dublin, Ireland.
authors.forename: P J
authors.initials: PJ
authors.lastname: Pollock
authors.forename: M
authors.initials: M
authors.lastname: Prendergast
authors.forename: J
authors.initials: J
authors.lastname: Schumacher
authors.forename: C R
authors.initials: CR
authors.lastname: Bellenger
mesh_terms: D000210:Acute-Phase Reaction / Q000097:blood / Q000662:veterinary*; D000818:Animals; D017558:Elective Surgical Procedures / Q000662:veterinary; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006242:Haptoglobins / Q000378:metabolism; D006454:Hemoglobins; D006734:Horse Diseases / Q000097:blood / Q000601:surgery*; D006736:Horses / Q000097:blood / Q000601:surgery*; D008297:Male; D000685:Serum Amyloid A Protein / Q000378:metabolism; D013514:Surgical Procedures, Operative / Q000662:veterinary
chemical_list: D006242:Haptoglobins; D006454:Hemoglobins; D000685:Serum Amyloid A Protein; D005340:Fibrinogen