title: Selective reduction in amygdala volume in pediatric anxiety disorders: a voxel-based morphometry investigation.
abstract: BACKGROUND
  Significant controversy has emerged concerning pediatric anxiety disorders. Some researchers question the justification for diagnosing and treating pediatric anxiety disorders, owing to concerns about the inappropriate medicalization of social problems. Others note the importance of diagnosis and treatment, given that pediatric anxiety disorders represent a strong risk factor for serious adult mental disorders. We examine the neural correlates of pediatric anxiety disorders, to consider the validity of the categorization scheme used in recent treatment studies.
  
  
  METHODS
  Using inclusion criteria derived from recent treatment trials, we compared gray matter volume throughout the brain in children with and without anxiety. Morphometric analyses used optimized voxel-based morphometry, an automated method for examining structural changes throughout the brain.
  
  
  RESULTS
  Reductions in left amygdala gray matter volume were noted for patients with anxiety disorders relative to comparison subjects.
  
  
  CONCLUSIONS
  We discuss implications of these findings for current controversies.
authors.affiliation: Beckman Institute, University of Illinois, Urbana, Illinois, USA. milham01@med.nyu.edu
authors.forename: Michael P
authors.initials: MP
authors.lastname: Milham
authors.forename: Allison C
authors.initials: AC
authors.lastname: Nugent
authors.forename: Wayne C
authors.initials: WC
authors.lastname: Drevets
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Dickstein
authors.forename: Ellen
authors.initials: E
authors.lastname: Leibenluft
authors.forename: Monique
authors.initials: M
authors.lastname: Ernst
authors.forename: Dennis
authors.initials: D
authors.lastname: Charney
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Pine
mesh_terms: D000293:Adolescent; D000679:Amygdala / Q000473:pathology*; D001008:Anxiety Disorders / Q000473:pathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D002648:Child; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging; D008297:Male; D011569:Psychiatric Status Rating Scales