title: [Neurological manifestations in Sjögren syndrome].
abstract: OBJECTIVE
  To describe clinical and physiopathological aspects of neurological involvement in neurological Sjögren syndrome (SS) and to overview biological markers and therapeutical aspects.
  
  
  BACKGROUND
  Neurological complications during SS may occur between 8.5 and 70%. Peripheral nervous system (PNS) involvement is well none but data concerning central nervous system (CNS) symptoms have been rarely described. In the present study we detail more precisely the heterogeneity of the neurological manifestation in SS. Recently new biological of SS such as alpha-fodrin antibodies have been described but there interest remain controversial. Furthermore, therapeutical data are scarce and there is to date no consensual guidelines for the therapeutical approach.
  
  
  CONCLUSIONS
  Recent data concerning neurological involvement in SS confirm the heterogeneity of clinical presentations that may mimic stroke or multiple sclerosis. They underline the need for new biological markers. Furthermore, multicentric, randomized trials should be assessed in order to give us some therapeutical guidelines.
authors.affiliation: Clinique neurologique, hôpital R.-Salengro, CHRU de Lille, 59037 Lille cedex, France. j-deseze@chru-lille.fr
authors.forename: J
authors.initials: J
authors.lastname: de Seze
authors.forename: S
authors.initials: S
authors.lastname: Delalande
authors.forename: P
authors.initials: P
authors.lastname: Vermersch
mesh_terms: D015415:Biomarkers; D006801:Humans; D009422:Nervous System Diseases / Q000209:etiology*; D010523:Peripheral Nervous System Diseases / Q000209:etiology*; D012859:Sjogren's Syndrome / Q000503:physiopathology*
chemical_list: D015415:Biomarkers