Decreased MCF-7 breast cancer cell proliferation by serum from a selected line of beef cattle.
One way to combat or treat breast cancer, the most common cancer among women, is to decrease or prevent proliferation of cancerous cells. Many animal species of agricultural importance have been selected for various growth traits, typically through altered proliferative capacity of some cell types. Previous studies in two lines of cattle divergently selected for serum IGF-I concentration have shown that low IGF-I cattle had increased growth rates and high IGF-I cattle had decreased growth rates. Serum from either the high or low IGF-I lines of cattle were administered to MCF-7 breast cancer cell lines and doubling times were determined. The MCF-7 cells treated with serum from cattle with high serum IGF-I concentrations took 26% longer to double than MCF-7 cells treated with serum from cattle with low serum IGF-I concentrations. In conclusion, model systems employing agricultural animals may provide novel insight into mechanisms of cell proliferation.
Updike
Michael S
MS
Department of Animal Sciences, The Ohio State University, Columbus, OH 43210, USA.
Davis
Michael E
ME
Wang
Li-Shu
LS
Huang
Yi-Wen
YW
Wick
MacDonald
M
Lin
Young C
YC
D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology*; D002417:Cattle / Q000097:blood*; D002454:Cell Differentiation / Q000502:physiology; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D003470:Culture Media; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism / Q000494:pharmacology; D044967:Serum
D003470:Culture Media; D007334:Insulin-Like Growth Factor I