title: Neuroglial responses to CNS injury: prospects for novel therapeutics.
abstract: Immune-mediated therapies can reduce the relapse rate in multiple sclerosis. However, there is no clear-cut evidence that any of these therapies substantially alter the long-term outcome for patients with progressive multiple sclerosis. The neurological disability that all too frequently accompanies multiple sclerosis is ultimately due to injury to target cells, principally oligodendroglia, within the nervous system. Recent data suggest that activation of leukemia inhibitory factor-receptor signaling is an important component of a neurobiological response that serves to limit the extent of immune-mediated injury. Therefore, inactivation of this pathway could provide a novel approach to the treatment of demyelinating disease.
authors.affiliation: University of Melbourne, Centre for Neuroscience, Victoria 3010, Australia. t.kilpatrick@hfi.unimelb.edu.au
authors.forename: Trevor J
authors.initials: TJ
authors.lastname: Kilpatrick
authors.forename: Helmut
authors.initials: H
authors.lastname: Butzkueven
authors.forename: Ben
authors.initials: B
authors.lastname: Emery
authors.forename: Mark
authors.initials: M
authors.lastname: Marriott
authors.forename: Bruce V
authors.initials: BV
authors.lastname: Taylor
authors.forename: Niall
authors.initials: N
authors.lastname: Tubridy
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D035843:Biomedical Research; D002493:Central Nervous System Diseases / Q000276:immunology / Q000473:pathology / Q000628:therapy; D016207:Cytokines / Q000502:physiology; D004195:Disease Models, Animal; D005104:Expert Testimony; D006801:Humans; D015850:Interleukin-6 / Q000627:therapeutic use; D053605:Leukemia Inhibitory Factor; D008954:Models, Biological; D009103:Multiple Sclerosis / Q000276:immunology / Q000473:pathology; D009414:Nerve Growth Factors / Q000627:therapeutic use; D009457:Neuroglia / Q000145:classification / Q000276:immunology / Q000502:physiology*; D018121:Receptors, Cytokine / Q000502:physiology
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D015850:Interleukin-6; C507837:LIF protein, human; D053605:Leukemia Inhibitory Factor; D009414:Nerve Growth Factors; D018121:Receptors, Cytokine