title: Growth factor signalling networks in breast cancer and resistance to endocrine agents: new therapeutic strategies.
abstract: Recent evidence demonstrates that growth factor networks are highly interactive with the estrogen receptor (ER) in the control of breast cancer growth and development. As such, tumor responses to anti-hormones are likely to be a composite of the ER and growth factor inhibitory activity of these agents, with alterations/aberrations in growth factor signalling providing a mechanism for the development of anti-hormone resistance. In this light, the current article focuses on illustrating the relationship between growth factor signalling and anti-hormone failure in our in-house tumor models of breast cancer and describes how we are now beginning to successfully target their actions to improve the effects of anti-hormonal drugs and to block aggressive disease progression.
authors.affiliation: Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3XF, Wales, UK. nicholsonri@cf.ac.uk
authors.forename: R I
authors.initials: RI
authors.lastname: Nicholson
authors.forename: I R
authors.initials: IR
authors.lastname: Hutcheson
authors.forename: D
authors.initials: D
authors.lastname: Britton
authors.forename: J M
authors.initials: JM
authors.lastname: Knowlden
authors.forename: H E
authors.initials: HE
authors.lastname: Jones
authors.forename: M E
authors.initials: ME
authors.lastname: Harper
authors.forename: S E
authors.initials: SE
authors.lastname: Hiscox
authors.forename: D
authors.initials: D
authors.lastname: Barrow
authors.forename: J M W
authors.initials: JM
authors.lastname: Gee
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism*; D019008:Drug Resistance, Neoplasm; D004359:Drug Therapy, Combination; D066246:ErbB Receptors / Q000378:metabolism; D005260:Female; D006133:Growth Substances / Q000378:metabolism*; D006727:Hormone Antagonists / Q000627:therapeutic use; D006801:Humans; D009361:Neoplasm Invasiveness; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D015398:Signal Transduction; D013629:Tamoxifen / Q000627:therapeutic use; D017211:Treatment Failure
chemical_list: D006133:Growth Substances; D006727:Hormone Antagonists; D011960:Receptors, Estrogen; D013629:Tamoxifen; D066246:ErbB Receptors