title: [The unbalance of membrane phospholipid composition of Escherichia coli affects the PPHO promoter activity].
abstract: Activity of phosphate PPHO or arabinose PBAD promoter of Escherichia coli has been studied depending on the content of zwitter-ionic phosphatidylethanolamine (PE) and anionic phospholipids in membranes. In the absence of PE or under significant decrease in the content of anionic phospholipids, there is a significant decline of PPHO promoter activity but not PBAD promoter. Since the PPHO promoter belongs to the Pho-regulon--a member of the family of two-component regulatory systems of signal transduction having membrane sensors, the regulation of gene expression by phospholipids is presumed to be realized through a membrane sensor.
authors.forename: V V
authors.initials: VV
authors.lastname: Golovastov
authors.forename: L A
authors.initials: LA
authors.lastname: Krasovskaia
authors.forename: E V
authors.initials: EV
authors.lastname: Anisimova
authors.forename: V N
authors.initials: VN
authors.lastname: Shukin
authors.forename: A O
authors.initials: AO
authors.lastname: Badiakina
authors.forename: M A
authors.initials: MA
authors.lastname: Nesmeianova
mesh_terms: D001483:Base Sequence; D004269:DNA, Bacterial; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D008563:Membrane Lipids / Q000378:metabolism*; D008969:Molecular Sequence Data; D010743:Phospholipids / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D015398:Signal Transduction
chemical_list: D004269:DNA, Bacterial; D008563:Membrane Lipids; D010743:Phospholipids