NF-kappa B comes home.
NF-kappa B was discovered because of its binding to the Ig kappa locus intronic enhancer, but deletion of its binding site does not appear to affect V-to-J kappa rearrangement. New work by Verkoczy et al. in this issue of Immunity suggests that NF-kappa B regulates Ig kappa rearrangement after all, by activating RAG expression during receptor editing.
Amin
Rupesh H
RH
Department of Molecular and Cell Biology, Division of Immunology, University of California, Berekely, 94720, USA.
Schlissel
Mark S
MS
D000818:Animals; D004742:Enhancer Elements, Genetic; D018398:Homeodomain Proteins / Q000378:metabolism; D007145:Immunoglobulin kappa-Chains / Q000235:genetics / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism*
D018398:Homeodomain Proteins; D007145:Immunoglobulin kappa-Chains; D016328:NF-kappa B; C064658:RAG-1 protein