title: Increased carotid wall thickening after radiotherapy on the neck.
abstract: Patients treated for head and neck tumours with local radiotherapy (RT) on the neck harbour an increased risk of stroke. This may be due to accelerated atherosclerotic changes within the RT-field; however, the real impact of local RT on the carotid artery remains debatable. The aim of the present study was to assess the difference in carotid wall thickness (intima-media thickness) in 42 unilaterally irradiated parotid tumour patients by performing B-mode ultrasonography. A mean difference in intima-media thickness (IMT) of the irradiated compared with the non-irradiated carotid artery of 0.30 mm (P=0.031) was found. A significant correlation was established with a longer post-RT interval (P=0.008). RT on the neck is associated with increased thickening of carotid IMT. Screening and treatment of additional cerebrovascular risk factors which contribute to further IMT thickening and stroke development is recommended, especially in radiotherapy patients with a favourable prognosis.
authors.affiliation: Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. l.dorresteijn@neuro.umcn.nl
authors.forename: Lucille D A
authors.initials: LD
authors.lastname: Dorresteijn
authors.forename: Arnoud C
authors.initials: AC
authors.lastname: Kappelle
authors.forename: Natasja M J
authors.initials: NM
authors.lastname: Scholz
authors.forename: Marten
authors.initials: M
authors.lastname: Munneke
authors.forename: José T
authors.initials: JT
authors.lastname: Scholma
authors.forename: Alfons J M
authors.initials: AJ
authors.lastname: Balm
authors.forename: Harry
authors.initials: H
authors.lastname: Bartelink
authors.forename: Willem
authors.initials: W
authors.lastname: Boogerd
mesh_terms: D008949:Adenoma, Pleomorphic / Q000532:radiotherapy / Q000601:surgery; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000532:radiotherapy / Q000601:surgery; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging / Q000473:pathology / Q000528:radiation effects*; D016893:Carotid Stenosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000532:radiotherapy / Q000601:surgery; D011832:Radiation Injuries / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D011878:Radiotherapy / Q000009:adverse effects*; D012307:Risk Factors; D020521:Stroke / Q000209:etiology / Q000473:pathology; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology / Q000528:radiation effects*; D014463:Ultrasonography