Rel/Nuclear factor-kappa B apoptosis pathways in human cervical cancer cells.
Cervical cancer is considered a common yet preventable cause of death in women. It has been estimated that about 420 women out of the 1400 women diagnosed with cervical cancer will die during 5 years from diagnosis. This review addresses the pathogenesis of cervical cancer in humans with a special emphasis on the human papilloma virus as a predominant cause of cervical cancer in humans. The current understanding of apoptosis and regulators of apoptosis as well as their implication in carcinogenesis will follow. A special focus will be given to the role of Rel/NF-kappaB family of genes in the growth and chemotherapeutic treatment of the malignant HeLa cervical cells emphasizing on Xrel3, a cRel homologue.
Shehata
Marlene F
MF
Division of Basic Sciences, Faculty of Medicine, Memorial University of Newfoundland, St, John's, A1B 3V6, Canada. mshehata@ottawaheart.ca.