[Study of immunoregulation of dendritic cells in allergic rhinitis].
OBJECTIVE
To investigate the immunoregulation of dendritic cells in allergic rhinitis.


METHODS
Adopting the cell culture and the enzyme linked immunosorbant assay to examine the patients' Th1/Th2 in the blood. Observing that how is the DC's function in immunoregulation of allergic rhinitis.


RESULTS
The concentration of the IFN-gamma advanced obviously in post-stimulatory supernatant liquid after using the mature DC.


CONCLUSIONS
The mature dendritic cells can polarize naive T-cells into Th1 effector cells, and are recognized as having a central role in the establishment of T-cell memory and peripheral immune tolerance. DC could be exploited as targets for therapy in asthma and allergic rhinitis.
Xie
Jun
J
Department of Otorhinolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Wang
Efen
E
Liao
Hui
H
Zhang
Ming
M
Liu
Jie
J
Liu
Lisi
L
D000293:Adolescent; D000328:Adult; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D018664:Interleukin-12 / Q000097:blood; D008297:Male; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
D018664:Interleukin-12; D007371:Interferon-gamma