title: Synthesis of thiosemicarbazone and 4-thiazolidinone derivatives and their in vitro anti-Toxoplasma gondii activity.
abstract: Thiosemicarbazone and 4-thiazolidinone derivatives were synthesized in one and two step, respectively, from thiosemicarbazide, in satisfactory yields. Then, the synthesized compounds were submitted to evaluation against host cells infected with Toxoplasma gondii. The present studies showed that thiosemicarbazones 2 and 4-thiazolidinone derivatives 3 were effective against intracellular T. gondii.
authors.affiliation: Departamento de Antibióticos, Universidade Federal de Pernambuco, Recife 50670-901, Brazil.
authors.forename: Rômulo P
authors.initials: RP
authors.lastname: Tenório
authors.forename: Cristiane S
authors.initials: CS
authors.lastname: Carvalho
authors.forename: Carla S
authors.initials: CS
authors.lastname: Pessanha
authors.forename: José G
authors.initials: JG
authors.lastname: de Lima
authors.forename: Antônio R
authors.initials: AR
authors.lastname: de Faria
authors.forename: Antônio J
authors.initials: AJ
authors.lastname: Alves
authors.forename: Edésio J T
authors.initials: EJ
authors.lastname: de Melo
authors.forename: Alexandre J S
authors.initials: AJ
authors.lastname: Góes
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014122:Toxoplasma / Q000187:drug effects*; D014709:Vero Cells
chemical_list: D000981:Antiprotozoal Agents; D013844:Thiazoles; D013882:Thiosemicarbazones