title: Do statins increase the risk of idiopathic polyneuropathy?
abstract: A recent European case-control study suggested that statins increase the risk for polyneuropathy, a rare but serious neurologic condition. This risk was assessed in 272 patients with idiopathic polyneuropathy and 1,360 matched controls in the Intermountain Health Care electronic database. It was found that statin use before diagnosis was not significantly greater in patients than controls (odds ratio 1.30, 95% confidence interval 0.3 to 2.1, p = 0.27), nor were doses different between patients and controls.
authors.affiliation: Cardiovascular Department, LDS Hospital, Cardiology Division, Intermountain Health Care, Salt Lake City, Utah 84143, USA. jeffrey.anderson@ihc.com
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Anderson
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Muhlestein
authors.forename: Tami L
authors.initials: TL
authors.lastname: Bair
authors.forename: Steven
authors.initials: S
authors.lastname: Morris
authors.forename: Aaron N
authors.initials: AN
authors.lastname: Weaver
authors.forename: Donald L
authors.initials: DL
authors.lastname: Lappé
authors.forename: Dale G
authors.initials: DG
authors.lastname: Renlund
authors.forename: Robert R
authors.initials: RR
authors.lastname: Pearson
authors.forename: Kurt R
authors.initials: KR
authors.lastname: Jensen
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Horne
mesh_terms: D016022:Case-Control Studies; D016208:Databases, Factual; D019033:Delivery of Health Care, Integrated; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D007345:Insurance Claim Review; D008297:Male; D008875:Middle Aged; D011115:Polyneuropathies / Q000139:chemically induced*; D018570:Risk Assessment; D012307:Risk Factors; D014589:Utah
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors