title: Expression of Fgf19 in the developing chick eye.
abstract: Fibroblast growth factor 19 (FGF19) is a new member of the FGF family of growth factors. Here, we describe the localization of Fgf19 mRNA in the developing chick retina and lens in stages from the Hamburger and Hamilton stage 15 (HH15) to postnatal day 30 (P30). Fgf19 was expressed in a transient manner in postmitotic neuroblasts during the migration from the ventricular surface to their final location. Moreover, from HH31 (embryonic day 7, E7) on, a subset of lined up Fgf19 expressing cells was distributed in the outer region of the presumptive INL. These cells were Pax6 immunoreactive horizontal cells. During the last third of embryogenesis, Fgf19 expression in the retina was progressively down-regulated and was not detected at P30. Also, it was transiently expressed in the equatorial region of the lens.
authors.affiliation: Departamento de Biología Celular, Facultad de Veterinaria, Universidad de Extremadura, Avda. de la Universidad s/n, 10071 Cáceres, Spain. morcillo@unex.es
authors.forename: Javier
authors.initials: J
authors.lastname: Francisco-Morcillo
authors.forename: Hortensia
authors.initials: H
authors.lastname: Sánchez-Calderón
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Kawakami
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Izpisúa Belmonte
authors.forename: Matías
authors.initials: M
authors.lastname: Hidalgo-Sánchez
authors.forename: Gervasio
authors.initials: G
authors.lastname: Martín-Partido
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001973:Bromodeoxyuridine / Q000378:metabolism; D002642:Chick Embryo; D005123:Eye / Q000166:cytology* / Q000254:growth & development / Q000378:metabolism; D005136:Eye Proteins / Q000235:genetics / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D007150:Immunohistochemistry / Q000379:methods; D017403:In Situ Hybridization / Q000379:methods; D060850:LIM-Homeodomain Proteins; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors; D014404:Tubulin / Q000378:metabolism
chemical_list: D005136:Eye Proteins; D018398:Homeodomain Proteins; D060850:LIM-Homeodomain Proteins; D009419:Nerve Tissue Proteins; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D012097:Repressor Proteins; D014157:Transcription Factors; D014404:Tubulin; C063843:insulin gene enhancer binding protein Isl-1; D005346:Fibroblast Growth Factors; D001973:Bromodeoxyuridine