[Immunogenecity induced by the VA-MENGOC-BC antimeningococcal vaccine against the ATCC C11. N. meningitidis strain in adolescents 12 years after being vaccinated].
The antibodies' response induced by the VA-MENGOC-BC Cuban antimeningococcal vaccine against the ATCC C11 strain was studied by Bactericidal Serum Trial and ELISA among 184 adolescents from a polytechnic, in Ciego de Avila, that had been immnunized in mass campaings 12 years before. Blood samples were taken before administering the first dose (T0), 4 weeks later (T1), and 4 weeks after the second dose (T2). 12 years after vaccination, 25% of the adolescents presented bactericidal titers > or =1:8 against the evaluated strain. 78% showed a concentration of antibodies over the limit of detection against the meningococcus C capsular polyssacharide. The percentages of seroconversion after the first dose were 59 by Bactericidal Serum Trial and 82 by ELISA. There were no significant differences (p > 0.05) between the results obtained after the first and second dose by boths trials. The reimmnunization with 2 doses of the vaccine did not cause hyporesponse against the ATCC C11 strain in this age group.
Camaraza
Maria A
MA
Instituto Finlay, Avenida 27 No. 19805, La Lisa, AP 16017, CP 11600, Ciudad de La Habana, Cuba. camaraza@finlay.edu.cu
Ochoa
Rolando
R
Arnet
Aida G
AG
Sotolongo
Franklin
F
Martínez
Isabel
I
Cuevas
Iván
I
Hernández
Dairis
D
D000293:Adolescent; D000907:Antibodies, Bacterial / Q000097:blood*; D006801:Humans; D022401:Meningococcal Vaccines / Q000276:immunology*; D009345:Neisseria meningitidis / Q000276:immunology*; D011446:Prospective Studies; D013997:Time Factors
D000907:Antibodies, Bacterial; D022401:Meningococcal Vaccines