Bone-targeting macromolecular therapeutics.
Musculoskeletal diseases such as osteoporosis are recognized as major public health problems worldwide. Many novel therapeutic agents have been identified for the treatment of these diseases. However, the majority of them are not specific to hard tissue, resulting significant toxicity. Bone-targeting drug delivery systems based on water-soluble polymers can specifically direct candidate drugs to bone thereby reducing side effects due to non-specific tissue interactions. Incorporation of a targeting moiety, a drug release mechanism, drug selection and optimization of the polymer carrier are all essential elements in the development of bone-targeting macromolecular therapeutics. Successful clinical application of this approach can significantly contribute to the development of treatments for many musculoskeletal diseases.
Wang
Dong
D
Department of Pharmaceutics and Pharmaceutical Chemistry/CCCD, University of Utah, Salt Lake City, UT 84112, USA.
Miller
Scott C
SC
Kopecková
Pavla
P
Kopecek
Jindrich
J
D000818:Animals; D001847:Bone Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D001842:Bone and Bones / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D056657:Cathepsin K; D002403:Cathepsins / Q000037:antagonists & inhibitors; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000037:antagonists & inhibitors; D020782:Matrix Metalloproteinases / Q000378:metabolism; D011108:Polymers / Q000737:chemistry*; D011355:Prodrugs / Q000737:chemistry / Q000627:therapeutic use*; D011458:Prostaglandins E / Q000037:antagonists & inhibitors; D018078:Receptors, Prostaglandin E / Q000037:antagonists & inhibitors; D012995:Solubility; D025262:Vacuolar Proton-Translocating ATPases / Q000037:antagonists & inhibitors; D018909:src Homology Domains
D004337:Drug Carriers; D039302:Integrin alphaVbeta3; D011108:Polymers; D011355:Prodrugs; D011458:Prostaglandins E; D018078:Receptors, Prostaglandin E; D002403:Cathepsins; C534130:CTSK protein, human; D056657:Cathepsin K; D020782:Matrix Metalloproteinases; D025262:Vacuolar Proton-Translocating ATPases