[Low-density lipoproteins with different capacity for aggregation].
Preparations of low-density lipoproteins from healthy donor blood contain lipoprotein particles with different capacity for aggregation: upon stirring, some particles form aggregates significantly more quick than others. After stirring, lipoprotein particles are separated by ultracentrifugation into two fractions: a fraction of large aggregates and a fraction of small particles without intermediate forms. It is known that lipoprotein aggregates can accelerate intracellular accumulation of lipids. Therefore, it is supposed that particles of high aggregation ability are more atherogenic.
Dobretsov
G E
GE
Gularian
S K
SK
Panasenko
O M
OM
Orekhov
A N
AN
Isakova
S I
SI
D002499:Centrifugation, Density Gradient; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood / Q000737:chemistry*
D008077:Lipoproteins, LDL