title: Hypoglycemic effects of turmeric (Curcuma longa L. rhizomes) on genetically diabetic KK-Ay mice.
abstract: The turmeric (Curcuma longa L. rhizomes) EtOH extract significantly suppressed an increase in blood glucose level in type 2 diabetic KK-A(y) mice. In an in vitro evaluation, the extract stimulated human adipocyte differentiation in a dose-dependent manner and showed human peroxisome proliferator-activated receptor (PPAR)-gamma ligand-binding activity in a GAL4-PPAR-gamma chimera assay. The main constituents of the extract were identified as curcumin, demethoxycurcumin, bisdemethoxycurcumin, and ar-turmerone, which had also PPAR-gamma ligand-binding activity. These results indicate that turmeric is a promising ingredient of functional food for the prevention and/or amelioration of type 2 diabetes and that curcumin, demethoxycurcumin, bisdemethoxycurcumin, and ar-turmerone mainly contribute to the effects via PPAR-gamma activation.
authors.forename: Minpei
authors.initials: M
authors.lastname: Kuroda
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Mimaki
authors.forename: Tozo
authors.initials: T
authors.lastname: Nishiyama
authors.forename: Tatsumasa
authors.initials: T
authors.lastname: Mae
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kishida
authors.forename: Misuzu
authors.initials: M
authors.lastname: Tsukagawa
authors.forename: Kazuma
authors.initials: K
authors.lastname: Takahashi
authors.forename: Teruo
authors.initials: T
authors.lastname: Kawada
authors.forename: Kaku
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Mikio
authors.initials: M
authors.lastname: Kitahara
mesh_terms: D000818:Animals; D030024:Curcuma; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000235:genetics*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D051379:Mice; D027343:Rhizome
chemical_list: D007004:Hypoglycemic Agents