title: [18F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) in aggressive lymphoma: an early prognostic tool for predicting patient outcome.
abstract: Assessment of early therapeutic response using metabolic imaging is potentially useful to determine prognosis in aggressive lymphoma. Between January 2000 and January 2004, 90 patients with newly diagnosed aggressive lymphoma (median age 53 years, 94% diffuse large B-cell) were prospectively explored with [18F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) prior to induction chemotherapy, after 2 cycles ("early PET"), and after induction completion. Therapeutic response was evaluated using conventional diagnostic methods at 4 cycles. Induction treatment with an anthracycline-containing regimen was administered to all patients, associated with rituximab in 41%. According to the International Prognostic Index (IPI), 37 patients and 53 patients belonged to the lower- and higher-risk groups, respectively. At midinduction, "early PET" was considered negative in 54 patients and positive in 36. After completion of induction, 83% of PET-negative patients achieved complete remission compared with only 58% of PET-positive patients. Outcome differed significantly between PET-negative and PET-positive groups; the 2-year estimates of event-free survival reached 82% and 43%, respectively (P < .001), and the 2-year estimates of overall survival reached 90% and 61%, respectively (P = .006). Predictive value of "early PET" was observed in both the lower-risk and higher-risk groups, indicating prognostic independence from the IPI. Therefore, FDG-PET should be an early guide to first-line strategies in aggressive lymphoma.
authors.affiliation: Department of Clinical Hematology, H. Mondor Hospital, Paris XII University, Assistance Publique-Hôpitaux de Paris, Créteil, France. corinne.haioun@hmn.aphp.fr
authors.forename: Corinne
authors.initials: C
authors.lastname: Haioun
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Itti
authors.forename: Alain
authors.initials: A
authors.lastname: Rahmouni
authors.forename: Pauline
authors.initials: P
authors.lastname: Brice
authors.forename: Jean-Didier
authors.initials: JD
authors.lastname: Rain
authors.forename: Karim
authors.initials: K
authors.lastname: Belhadj
authors.forename: Philippe
authors.initials: P
authors.lastname: Gaulard
authors.forename: Laurent
authors.initials: L
authors.lastname: Garderet
authors.forename: Eric
authors.initials: E
authors.lastname: Lepage
authors.forename: Felix
authors.initials: F
authors.lastname: Reyes
authors.forename: Michel
authors.initials: M
authors.lastname: Meignan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018943:Anthracyclines / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents / Q000627:therapeutic use; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011379:Prognosis; D011446:Prospective Studies; D012074:Remission Induction; D000069283:Rituximab; D016019:Survival Analysis
chemical_list: D018943:Anthracyclines; D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D019788:Fluorodeoxyglucose F18; D000069283:Rituximab