title: Methylprednisolone pulse therapy for massive lymphadenopathy in a child with intravenous immunoglobulin-resistant Kawasaki disease.
abstract: Kawasaki disease (KD) is an acute febrile multi-system vasculitis of unknown etiology. The diagnosis is based on clinical features. We describe a case of intravenous immunoglobulins (IVIG)-resistant KD presenting with persistent fever and massive cervical lymphadenopathy associated with mild respiratory distress. The symptoms resolved after methylprednisolone pulse therapy. High-dose pulse steroid may be an alternative therapeutic option in KD which presents with possible life-threatening complications or failure to respond to high-dose IVIG infusion.
authors.affiliation: Department of Pediatric Allergy, Immunology and Rheumatology, Chang Gung Children's Hospital, Kaohsiung, Taiwan.
authors.forename: Hsin Hsu
authors.initials: HH
authors.lastname: Chen
authors.forename: Po Mai
authors.initials: PM
authors.lastname: Liu
authors.forename: Chin Nam
authors.initials: CN
authors.lastname: Bong
authors.forename: Yu Tsun
authors.initials: YT
authors.lastname: Wu
authors.forename: Kuender D
authors.initials: KD
authors.lastname: Yang
authors.forename: Chih Lu
authors.initials: CL
authors.lastname: Wang
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002675:Child, Preschool; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008206:Lymphatic Diseases; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications / Q000188:drug therapy*; D009333:Neck; D013624:Taiwan
chemical_list: D000893:Anti-Inflammatory Agents; D016756:Immunoglobulins, Intravenous; D008775:Methylprednisolone