title: Sections of the nipple and quadrants in mastectomy specimens for carcinoma are of limited value.
abstract: OBJECTIVE
  To assess the value of nipple and quadrant sections in mastectomy specimens for carcinoma in detecting Paget's disease and multifocal carcinoma.
  
  
  METHODS
  Two hundred and forty eight consecutive mastectomies performed for carcinoma were reviewed. The presence of Paget's disease of the nipple and mode of identification of any multifocal carcinoma was recorded.
  
  
  RESULTS
  Nipple sections showed Paget's disease in eight specimens: in five the diagnosis had been made on previous biopsy and in three (1%) this was a new diagnosis. In the 220 specimens in which all four quadrants were sampled, multifocal disease was identified more often in specimens with invasive carcinoma (39 of 186; 21%) than in those with only ductal carcinoma in situ (0 of 34). In specimens with invasive carcinoma, multifocality was identified macroscopically in 20: on microscopy of tumour sections in four, on microscopic examination of quadrant sections in 11, in the nipple in three, and in both quadrant and nipple sections in one. Overall, multifocality was found on microscopic examination of quadrant or nipple sections in 15 of 220 specimens (7%).
  
  
  CONCLUSIONS
  The low frequency of detection of multifocality or Paget's disease in nipple and quadrant sections from mastectomy specimens, combined with the fact that such findings do not affect patient management, suggest that nipple and quadrant sections should only be taken if resources permit.
authors.affiliation: Department of Histopathology, City Hospital, Hucknall Road, Nottingham NG5 1PB, UK.
authors.forename: K
authors.initials: K
authors.lastname: Sikand
authors.forename: A H S
authors.initials: AH
authors.lastname: Lee
authors.forename: S E
authors.initials: SE
authors.lastname: Pinder
authors.forename: C W
authors.initials: CW
authors.lastname: Elston
authors.forename: I O
authors.initials: IO
authors.lastname: Ellis
mesh_terms: D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology*; D002278:Carcinoma in Situ / Q000473:pathology; D005260:Female; D006801:Humans; D008408:Mastectomy / Q000379:methods; D009361:Neoplasm Invasiveness; D009558:Nipples / Q000473:pathology; D010144:Paget's Disease, Mammary / Q000473:pathology*