title: [The differential expression of hypoxia-inducible factor-1alpha in placenta tissues from pregnancy induced hypertension and normal pregnancy].
abstract: OBJECTIVE
  To explore the differential expression of hypoxia-inducible factor-1alpha (HIF-1alpha) in placenta tissues from pregnancy induced hypertension and normal pregnancy.
  
  
  METHODS
  The expression of HIF-1alpha protein and mRNA was detected by Western blot and real-time PCR, respectively.
  
  
  RESULTS
  As compared with the expression levels of HIF-1alpha protein and mRNA in placenta tissues from normal pregnancy, those from pregnancy induced hypertension increased notably (P<0.05).
  
  
  CONCLUSIONS
  The high expression of HIF-1alpha in the placenta tissues pregnancy induced may relate with pathogenesis and pathophysiological process of hypertension.
authors.affiliation: Department of Obstetrics and Gynecology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.
authors.forename: Wei-guang
authors.initials: WG
authors.lastname: Wu
authors.forename: Yuan-qing
authors.initials: YQ
authors.lastname: Yao
authors.forename: Dong-hong
authors.initials: DH
authors.lastname: Li
authors.forename: Yue-cheng
authors.initials: YC
authors.lastname: Yu
authors.forename: Xiao-bin
authors.initials: XB
authors.lastname: Fan
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000328:Adult; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
chemical_list: D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D012333:RNA, Messenger