title: Torsin A haplotype predisposes to idiopathic dystonia.
abstract: Previous work has suggested that in many neurological diseases genetic variability in the loci predisposing subjects to autosomal dominant disease contributes to the risk of sporadic disease. Here, using a population-based sample of dystonia cases, we show an association with the torsin A haplotype and sporadic idiopathic dystonia.
authors.affiliation: Laboratory of Neurogenetics, Porter Building, Bethesda, MD, USA.
authors.forename: Jordi
authors.initials: J
authors.lastname: Clarimon
authors.forename: Hilmir
authors.initials: H
authors.lastname: Asgeirsson
authors.forename: Andrew
authors.initials: A
authors.lastname: Singleton
authors.forename: Finnbogi
authors.initials: F
authors.lastname: Jakobsson
authors.forename: Haukur
authors.initials: H
authors.lastname: Hjaltason
authors.forename: John
authors.initials: J
authors.lastname: Hardy
authors.forename: Sigurlaug
authors.initials: S
authors.lastname: Sveinbjornsdottir
mesh_terms: D000483:Alleles; D004421:Dystonia / Q000453:epidemiology / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D018832:Molecular Chaperones / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011153:Population
chemical_list: D018832:Molecular Chaperones; C108175:TOR1A protein, human