[Expression of stromal cell derived factor-1(SDF-1) and its receptor CXCR4 in hematologic malignancies].
The aim was to analyze the expression level of stromal cell derived factor-1 (SDF-1) and its functional chemokine receptor CXCR4 in the patients with hematologic malignant tumor and their clinic significance. 28 patients with hematologic malignant tumor and 12 normal controls were chosen to be experimental objects. CXCR4 expressed on the cell membrane in bone marrow was enumerated by flow cytometry and serum level of SDF-1 was determined by ELISA assay. The result showed that the expression of SDF-1 and CXCR4 in hematologic malignant tumor were higher than that in normal controls, and the expression levels of two molecules were correlated. What is more, the different hematologic malignant tumor had different CXCR4 expression. In conclusion, the high expression of SDF-1 and CXCR4 in serum and bone marrow cells can be used as detective factors to hematologic malignant tumor. A correlation exists between the high expression of CXCR4 and the infiltration of hematologic malignant cells.
Zeng
Dong-Feng
DF
Department of Hematology, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China.
Kong
Pei-Yan
PY
Chen
Xing-Hua
XH
Peng
Xian-Gui
XG
Wei
Li
L
Chang
Cheng
C
Liu
Lin
L
Liu
Hong
H
Wang
Qing-Yu
QY
D000293:Adolescent; D000328:Adult; D000368:Aged; D054377:Chemokine CXCL12 / Q000097:blood*; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005434:Flow Cytometry; D019337:Hematologic Neoplasms / Q000097:blood*; D006801:Humans; D007938:Leukemia / Q000097:blood; D008223:Lymphoma / Q000097:blood; D008297:Male; D019718:Receptors, CXCR4 / Q000097:blood*
D054377:Chemokine CXCL12; D019718:Receptors, CXCR4