title: The treatment of osteochondral lesions using a combination of autologous chondrocyte implantation and autograft: three-year follow-up.
abstract: In this study a combination of autologous chondrocyte implantation (ACI) and the osteochondral autograft transfer system (OATS) was used and evaluated as a treatment option for the repair of large areas of degenerative articular cartilage. We present the results at three years post-operatively. Osteochondral cores were used to restore the contour of articular cartilage in 13 patients with large lesions of the lateral femoral condyle (n = 5), medial femoral condyle (n = 7) and patella (n = 1). Autologous cultured chondrocytes were injected underneath a periosteal patch covering the cores. After one year, the patients had a significant improvement in their symptoms and after three years this level of improvement was maintained in ten of the 13 patients. Arthroscopic examination revealed that the osteochondral cores became well integrated with the surrounding cartilage. We conclude that the hybrid ACI/OATS technique provides a promising surgical approach for the treatment of patients with large degenerative osteochondral defects.
authors.affiliation: Blond McIndoe Centre, Queen Victoria Hospital, East Grinstead, Sussex RH19 3DZ, UK. justin.sharpe@qvh.nhs.uk
authors.forename: J R
authors.initials: JR
authors.lastname: Sharpe
authors.forename: S U
authors.initials: SU
authors.lastname: Ahmed
authors.forename: J P
authors.initials: JP
authors.lastname: Fleetcroft
authors.forename: R
authors.initials: R
authors.lastname: Martin
mesh_terms: D000328:Adult; D001182:Arthroscopy / Q000379:methods; D002358:Cartilage, Articular / Q000473:pathology / Q000601:surgery* / Q000637:transplantation; D002478:Cells, Cultured; D019902:Chondrocytes / Q000637:transplantation*; D005260:Female; D005269:Femur / Q000473:pathology / Q000601:surgery; D006801:Humans; D007719:Knee Joint / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D010147:Pain Measurement / Q000379:methods; D010329:Patella / Q000473:pathology / Q000601:surgery; D014182:Transplantation, Autologous; D016896:Treatment Outcome