title: Von Willebrand's disease type I as a cause for subvitreal, retinal and subretinal haemorrhages.
abstract: BACKGROUND
  Young patients with vitreous, retinal and subvitreal haemorrhages without neovascularisation or prior trauma are a diagnostic challenge for the physician. In this case report, a patient is presented who developed unilateral, spontaneous, subvitreal, retinal and subretinal haemorrhages and was diagnosed with von Willebrand's disease.
  
  
  METHODS
  A 33-year-old Caucasian woman presented at our clinic with unilateral subvitreal, retinal and subretinal haemorrhages. The haemorrhages occurred spontaneously without prior trauma, and the patient had no history of prior bleeding complications. Analysis of the coagulation-fibrinolysis system and von Willebrand multimer analysis led to the diagnosis von Willebrand's disease type I.
  
  
  CONCLUSIONS
  Spontaneous subvitreal, retinal and subretinal haemorrhages may be associated with coagulation disorders. Especially in young patients, von Willebrand's disease should be considered as a possible cause.
authors.affiliation: University Eye Clinic, University of Regensburg, Franz-Josef-Strauss Allee 11, 93042, Regensburg, Germany. herrmann@eye-regensburg.de
authors.forename: Wolfgang Artur
authors.initials: WA
authors.lastname: Herrmann
authors.forename: Chris Patrick
authors.initials: CP
authors.lastname: Lohmann
authors.forename: Martina
authors.initials: M
authors.lastname: Demmler-Hackenberg
authors.forename: Veit-Peter
authors.initials: VP
authors.lastname: Gabel
mesh_terms: D000328:Adult; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D005260:Female; D005451:Fluorescein Angiography; D006490:Hemostatics / Q000627:therapeutic use; D006801:Humans; D012166:Retinal Hemorrhage / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D014823:Vitreous Hemorrhage / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D014842:von Willebrand Diseases / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D006490:Hemostatics; D003894:Deamino Arginine Vasopressin