title: Syntheses of novel heterocycles as anticancer agents.
abstract: Several pteridine analogues 4-13, 23-26 have been synthesized and tested in vitro against three cancer cell lines, MCF7 (breast), NCI-H460 (lung) and SF-268 (CNS). All tested pteridines can serve as novel templates for the anticancer chemotherapy and can serve as new leads in cancer chemotherapy.
authors.affiliation: School of Chemical Sciences and Pharmacy, University of East Anglia Norwich NR4 7TJ, UK. prem_chauhan_2000@yahoo.com
authors.forename: Prem M S
authors.initials: PM
authors.lastname: Chauhan
authors.forename: Cristina J A
authors.initials: CJ
authors.lastname: Martins
authors.forename: David C
authors.initials: DC
authors.lastname: Horwell
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D011621:Pteridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D011621:Pteridines