[Sildenafil for pulmonary hypertension treatment after cardiac surgery].
OBJECTIVE
To report on the use of sildenafil for pulmonary hypertension treatment of a newborn patient after cardiac surgery.


METHODS
A female, full term newborn infant with diagnosis of double outlet right ventricle, pulmonary hypoplasia and subaortic ventricular septal defect, was submitted to Blalock surgery in the first week of life. In postoperative the newborn had pulmonary hypertension and persistent hypoxia, without response to nitric oxide, but with improved oxygenation after continuous intravenous infusion of prostaglandin E1. After several failed attempts to discontinue prostaglandin E1, oral sildenafil was used. There was a decrease in pulmonary vascular resistance with consequent oxygenation improvement and 48 hours later it was possible to discontinue prostaglandin E1 infusion.


CONCLUSIONS
Sildenafil can be an alternative therapy for pulmonary hypertension, especially when there is no response to conventional therapy.
Bentlin
Maria Regina
MR
Departamento de Pediatria, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP. mbentlin@fmb.unesp.br
Saito
Adriana
A
De Luca
Ana Karina C
AK
Bossolan
Grasiela
G
Bonatto
Rossano C
RC
Martins
Antonio S
AS
Rugolo
Lígia M S S
LM
D006348:Cardiac Surgical Procedures; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy*; D007231:Infant, Newborn; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D010879:Piperazines / Q000627:therapeutic use*; D011184:Postoperative Period; D011687:Purines; D000068677:Sildenafil Citrate; D013450:Sulfones
D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate