[Efficacy of therapeutic and prophylactic actions of ultralow doses of antibodies to gamma-interferon in experimental murine model of herpes virus].
The process of the disease due to herpes simplex virus types 1 and 2 (HSV-1 and 2) was studied on white uninbred mice weighing 10 to 12 g. The animals were infected intracerebrally or intraperitoneally. Intraperitoneal contamination of the animals with MS strain of HSV-2 was used for the experimental model of the herpes simplex infection. The prophylactic antiherpes action of ultralow doses of the human gamma-interferon antibodies (ULD of anti-IFN-gamma) at a course of its intragastral administration was evaluated. The preparation was shown to have a significant (p < 0.05) protective effect in a dose of 10 LD50, evident from a 10-fold decrease of the HSV-2 accumulation in the brain, a lower percentage of the animal deaths and an increase of the average lifespan of the animals by 3.3 days. The study of the therapeutic action of ULD of anti-IFN-gamma at a course of its intragastral administration showed that the preparation had no significant positive effect on the disease process in the animals infected with HSV-2 in a dose of 10 LD50. However, a positive effect associated with delayed virus replication in the brain was observed in the study on the therapeutic effect of ULD of anti-IFN-gamma after its intragastral administration to the mice infected with a sublethal dose of the virus.
Susloparov
M A
MA
Makhova
N M
NM
Noskova
N V
NV
Pliasunov
I V
IV
Susloparov
I M
IM
Sergeev
A N
AN
Sherstoboev
E Iu
EIu
Martiushev-Poklad
A V
AV
Sergeeva
S A
SA
Epshteĭn
O I
OI
Glotov
A G
AG
Glotova
T I
TI
D000818:Animals; D000906:Antibodies / Q000008:administration & dosage* / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D006561:Herpes Simplex / Q000188:drug therapy*; D018259:Herpesvirus 1, Human; D018258:Herpesvirus 2, Human; D007371:Interferon-gamma / Q000276:immunology; D008297:Male; D051379:Mice; D011817:Rabbits; D014779:Virus Replication / Q000187:drug effects*
D000906:Antibodies; D007371:Interferon-gamma