Successful use of recombinant factor VIIa for emergency fasciotomy in a patient with hemophilia A and high-titer inhibitor unresponsive to factor VIII inhibitor bypassing activity.
We report a patient with hemophilia A and high-titer factor VIII inhibitor who developed compartment syndrome of his forearm following trauma. Emergency fasciotomy was performed. Initial hemostatic treatment with factor VIII inhibitor bypassing activity (FEIBA) was unsuccessful. Bleeding was controlled with recombinant factor VIIa.
Watts
Raymond G
RG
Division of Hematology-Oncology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA. rwatts@peds.uab.edu
D001323:Autoantibodies / Q000097:blood; D002648:Child; D004630:Emergencies; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D015942:Factor VIIa / Q000627:therapeutic use*; D000071938:Fasciotomy; D006467:Hemophilia A / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use
D001323:Autoantibodies; D011994:Recombinant Proteins; D005169:Factor VIII; D015942:Factor VIIa