title: Botulinum toxin type A (Botox) in the treatment of migraine and other headaches.
abstract: Botulinum toxin type A (Botox) is increasingly used in the management of migraine and tension-type headaches. The results from small placebo-controlled trials and extensive open-label experience has suggested a significant role for this neurotoxin in the management of refractory headache. Several large placebo-controlled trials of episodic and chronic migraine are currently underway.
authors.affiliation: Department of Neurology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA. todd@toddtroost.com
authors.forename: B Todd
authors.initials: BT
authors.lastname: Troost
mesh_terms: D019274:Botulinum Toxins, Type A / Q000008:administration & dosage* / Q000009:adverse effects* / Q000191:economics / Q000493:pharmacokinetics; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D006261:Headache / Q000188:drug therapy* / Q000191:economics / Q000378:metabolism; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy* / Q000191:economics / Q000378:metabolism; D009465:Neuromuscular Agents / Q000008:administration & dosage* / Q000009:adverse effects* / Q000191:economics / Q000493:pharmacokinetics; D016896:Treatment Outcome
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A