title: Incidence and prognostic importance of lymph node metastases in dogs with appendicular osteosarcoma: 228 cases (1986-2003).
abstract: OBJECTIVE
  To determine the incidence of regional lymph node metastasis in dogs with appendicular osteosarcoma and determine whether regional lymph node metastasis was associated with shortened disease-free interval or survival time.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  228 dogs with appendicular osteosarcoma in which regional lymph nodes were examined histologically at the time of limb amputation.
  
  
  METHODS
  Information collected from the medical records included signalment; affected site; initial serum alkaline phosphatase activity; whether treatment involved adjuvant chemotherapy and, if so, chemotherapeutic agents administered and number of treatments; disease-free interval; and survival time.
  
  
  RESULTS
  10 (4.4%) dogs had histologic evidence of regional lymph node metastasis at the time of amputation. Median disease-free interval for dogs without regional lymph node metastasis (238 days; range, 0 to 1,067 days) was significantly longer than median disease-free interval for dogs with regional lymph node metastasis (48 days; range, 2 to 269 days). Median survival time for dogs without lymph node metastasis (318 days; range, 20 to 1,711 days) was significantly longer than median survival time for dogs with lymph node metastasis (59 days; range, 19 to 365 days).
  
  
  CONCLUSIONS
  Results suggest that regional lymph node metastasis is rare in dogs with appendicular osteosarcoma but that dogs with lymph node metastasis have a poorer prognosis than do dogs without.
authors.affiliation: Animal Cancer Center and Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
authors.forename: Kim R
authors.initials: KR
authors.lastname: Hillers
authors.forename: William S
authors.initials: WS
authors.lastname: Dernell
authors.forename: Mary H
authors.initials: MH
authors.lastname: Lafferty
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Withrow
authors.forename: Susan E
authors.initials: SE
authors.lastname: Lana
mesh_terms: D000671:Amputation, Surgical / Q000662:veterinary; D000818:Animals; D018572:Disease-Free Survival; D004283:Dog Diseases / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D004285:Dogs; D005121:Extremities / Q000473:pathology / Q000601:surgery; D005260:Female; D015994:Incidence; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D012516:Osteosarcoma / Q000453:epidemiology / Q000556:secondary / Q000601:surgery / Q000662:veterinary*; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D013997:Time Factors