title: [Seasonal changes in bronchial reactivity in pollinosis patients].
abstract: OBJECTIVE
  To evaluate seasonal changes in bronchial hyperreactivity (BHR) in patients suffering from pollinosis, sensitive to Ryegrass engl.
  
  
  METHODS
  The studies were carried out on 26 patients and 20 healthy subjects. All the patients had a history of seasonal allergic rhinitis. The following measurements were performed outside and during the pollen season: bronchial provocation test (BPT) with metacholine and 4.5% NaCl, serum concentration of specific and total IgE.
  
  
  RESULTS
  Outside the pollen season additionally the BPT with Ryegrass engl. allergen was performed and 88% of the pollinosis patients had positive result of the test. After 4.5% NaCl bronchial challenge positive results had 2 out of 26 patients outside the season, and 3 during the season. Bronchial hyperreactivity to metacholine (PC20 < 8 mg/ml) were observed in 4/26 (15.4%) persons outside the season and in 7 (26.9) during the season. The healthy subjects had no bronchoconstriction neither after metacholine or 4.5% NaCl. During the pollen season the increase in serum concentration of tIgE and sIgE was observed only in pollinosis patient.
  
  
  CONCLUSIONS
  There was not found a correlation between BHR to the allergen and serum total IgE nor specific IgE concentration.
authors.affiliation: Klinika Alergologii i Chorób Wewnetrznych Akademii Medycznej w Bialymstoku. siergiejko@csk.pl
authors.forename: Zenon
authors.initials: Z
authors.lastname: Siergiejko
authors.forename: Ewa
authors.initials: E
authors.lastname: Swiebocka
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Siergiejko
authors.forename: Jerzy
authors.initials: J
authors.lastname: Hofman
mesh_terms: D000293:Adolescent; D000328:Adult; D016535:Bronchial Hyperreactivity / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D011058:Pollen; D006255:Rhinitis, Allergic, Seasonal / Q000503:physiopathology*; D012621:Seasons
chemical_list: D007073:Immunoglobulin E