title: Respiratory disorders and quality of sleep in patients on the waiting list for lung transplantation.
abstract: BACKGROUND
  The purpose of this study was to assess the quality of sleep and extent of respiratory disorders in patients awaiting lung transplantation as compared with a control group.
  
  
  METHODS
  From September 2003 to November 2003, 17 clinically stable patients on the waiting list for lung transplantation and 14 healthy controls (with similar age, gender, and body mass index) were studied. Diagnostic polysomnography (PSG) was carried out for all subjects.
  
  
  RESULTS
  Seventeen patients were included, 15 men and 2 women, aged 51 +/- 14 years. The indication for lung transplantation was emphysema in 7 cases, pulmonary fibrosis in 6, and "other" in 4. Patients awaiting lung transplantation had the following respiratory values: mean FEV1, 1105 mL (34% of predicted); PaO2, 54 mm Hg; and PaCO2, 44 mm Hg. Significant differences were found among the waiting-list patients in terms of predominance of light sleep, wakeful periods, and phase changes per sleep-hour, as compared with the control group. The recording of the respiratory events showed an apnea-hypopnea index of 6.13, sleeping time with SaO2 <90% of 1.80%, and a mean number of significant desaturations (<4%) of 6.38. There were no statistically significant differences with respect to the control group.
  
  
  CONCLUSIONS
  Poor quality of sleep was observed in patients awaiting lung transplantation as compared with a healthy control group. There was no evidence of more respiratory events or significant desaturations in these patients, probably due to the provision of supplementary oxygen therapy during the PSG.
authors.affiliation: Department of Respiratory Diseases, University Hospital Reina Sofia, Cordoba, Spain. neumonat@hotmail.com
authors.forename: N
authors.initials: N
authors.lastname: Pascual
authors.forename: B
authors.initials: B
authors.lastname: Jurado
authors.forename: J M
authors.initials: JM
authors.lastname: Rubio
authors.forename: F
authors.initials: F
authors.lastname: Santos
authors.forename: R
authors.initials: R
authors.lastname: Lama
authors.forename: A
authors.initials: A
authors.lastname: Cosano
mesh_terms: D004646:Emphysema / Q000453:epidemiology; D005260:Female; D006801:Humans; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012140:Respiratory Tract Diseases / Q000503:physiopathology*; D012890:Sleep / Q000502:physiology*; D012891:Sleep Apnea Syndromes / Q000503:physiopathology; D012893:Sleep Wake Disorders / Q000503:physiopathology*; D012895:Sleep, REM; D014850:Waiting Lists; D014851:Wakefulness / Q000502:physiology