title: [Design, synthesis and insulin-sensitizing activity of some peroxisome proliferator-activated gamma agonists].
abstract: OBJECTIVE
  To find new peroxisome proliferator-activated y agonists with high activity and low toxicity.
  
  
  METHODS
  Based on JTT-501 and JTT-20993, new isoxazolidine-3,5-dione and noncyclic 1,3-dicarbonyl compounds were designed and synthesized. Their insulin-sensitizing activities were evaluated.
  
  
  RESULTS
  Eight new compounds were obtained. The structures of synthesized compounds were characterized by NMR, MS and IR. Four compounds (1A-4A) showed insulin-sensitizing activities.
  
  
  CONCLUSIONS
  Compounds (1A and 3A) showed excellent insulin-sensitizing activities and should be worth further investigation.
authors.affiliation: R&D Department, Chengdu Di'ao Pharmaceutical Group Co., LTD, Chengdu 610041, China.
authors.forename: Chao-bin
authors.initials: CB
authors.lastname: Zhong
authors.forename: Xue-jun
authors.initials: XJ
authors.lastname: Zhu
authors.forename: Zhong-rong
authors.initials: ZR
authors.lastname: Liu
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Gao
authors.forename: Xue-chao
authors.initials: XC
authors.lastname: Wang
mesh_terms: D041721:3T3-L1 Cells; D000818:Animals; D005947:Glucose / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000819:agonists / Q000138:chemical synthesis / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D007555:Isoxazoles / Q000138:chemical synthesis / Q000494:pharmacology; D051379:Mice; D047495:PPAR gamma / Q000819:agonists / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D007555:Isoxazoles; D047495:PPAR gamma; D005947:Glucose; C112329:JTT 501