[Preliminary evaluation of the antiviral activity of the aqueous extract of Phyllanthus orbicularis vs HIV-1 infection].
The antiviral activity of the aqueous extract of Phyllanthus orbicularis, a member of the Euohorbiacea family, against the simple herpes virus typel was evaluated in cellular culture, specifically in fibroblasts of human prepucium, and in an animal model, Balb-c mice. The extracelullar effect of the extract on HIV-1 proved to be effective. A selective index of 44 was obtained, which shows a possible virucidal action on the particle. In the trial in vivo, the topical administration of the aqueous extract (12 mg/kg) reduced significantly the development of lesions in mice subcutaneously infected with HIV-1 (1 x 106 UFP). These results suggest the consideration of Phyllanthus orbicularis as a possible anti-HIV-1 candidate
Garcia
Suria Valdés
SV
Facultad de Biologia, Universidad de La Habana Calle 25 e/ J e l, El Vedado, Ciudad de La Habana, Cuba.
del Barrio Alonso
Gloria
G
Gaitén
Yamilet Gutiérrez
YG
Díaz
Luis Morier
LM
D000818:Animals; D002478:Cells, Cultured; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D029803:Phyllanthus; D010936:Plant Extracts / Q000494:pharmacology*
D010936:Plant Extracts