title: [Combination effect of pazufloxacin and anti-mrsa drugs against beta-lactam antibiotic induced vancomycin-resistant MRSA (BIVR)].
abstract: The in vitro combination effects of pazufloxacin (PZFX) with an anti-MRSA drug such as vancomycin (VCM), teicoplanin (TEIC), arbekacin (ABK), minocycline (MINO), rifampicin (RFP) and sulfamethoxazole-trimethoprim (ST) were investigated against 26 strains of beta-lactam antibiotic induced vancomycin-resistant MRSA (BIVR) by the checkerboard method. The additive and synergistic effects were observed with the combination of PZFX and VCM (50%, 13/26 strains), PZFX and TEIC (96%, 25/26 strains), PZFX and ABK (65%, 17/26 strains), PZFX and MINO (46%, 12/26 strains), PZFX and ST (54%, 14/26 strains). The synergistic effects were observed with the combination of PZFX and TEIC (4%, 1/26 strains), PZFX and ABK or MINO (15%, 4/26 strains). The antagonistic effects were observed with only PZFX and MINO (12%, 3/26 strains), others were all indifference.
authors.affiliation: Kitasato Research Center for Anti-infection Drugs, The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo, Japan.
authors.forename: Chie
authors.initials: C
authors.lastname: Yanagisawa
authors.forename: Hideaki
authors.initials: H
authors.lastname: Hanaki
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Oishi
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Uehara
authors.forename: Yukie
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Hidehito
authors.initials: H
authors.lastname: Matui
authors.forename: Keisuke
authors.initials: K
authors.lastname: Sunakawa
mesh_terms: D000617:Aminoglycosides / Q000494:pharmacology; D003982:Dibekacin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D024841:Fluoroquinolones / Q000494:pharmacology*; D066298:In Vitro Techniques; D016106:Methicillin Resistance; D008911:Minocycline / Q000494:pharmacology; D010078:Oxazines / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D017334:Teicoplanin / Q000494:pharmacology; D020713:Vancomycin Resistance; D047090:beta-Lactams / Q000494:pharmacology
chemical_list: D000617:Aminoglycosides; D024841:Fluoroquinolones; D010078:Oxazines; D047090:beta-Lactams; D003982:Dibekacin; C078052:pazufloxacin; D017334:Teicoplanin; D008911:Minocycline; C031986:arbekacin