Direct single gene mutational events account for radiation-induced intestinal adenoma yields in Apc(Min/+) mice.
Data on the induction of small intestinal tumors, predominantly adenomas, by X radiation in Apc(Min/+) mice are reported. Comparison of these incidences with estimates of radiation-induced direct single gene mutation frequencies taken from the literature support the hypothesis that direct mutational loss of Apc+ is the sole requirement for initiation of adenoma. Furthermore, estimates of radiation-induced initiation of adenoma per target stem cell in this animal model are similar to or less than radiation-induced direct somatic gene mutation frequencies. Therefore, while the data reported here do not preclude a role for genomic instability in tumor progression, it is not necessary in this model to postulate the involvement of radiation-induced transmissible genomic instability in initiation of intestinal adenoma.
Ellender
Michele
M
National Radiological Protection Board, Chilton, Didcot, Oxon, OX11 ORQ, United Kingdom. michele.ellender@nrpb.org
Harrison
John D
JD
Edwards
Alan A
AA
Bouffler
Simon D
SD
Cox
Roger
R
D000236:Adenoma / Q000235:genetics*; D000818:Animals; D005260:Female; D017491:Genes, APC; D042822:Genomic Instability; D007414:Intestinal Neoplasms / Q000235:genetics*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009154:Mutation; D009381:Neoplasms, Radiation-Induced / Q000235:genetics*