Zinc supplementation: neuroprotective or neurotoxic?
While zinc is essential for normal brain function and repair, recent work has implicated this trace element in the neuronal damage and death that follow traumatic brain injury, stroke, and seizure. Therefore, the development of new zinc-based therapeutic strategies will need to consider the emerging roles of zinc in the central nervous system.
Levenson
Cathy W
CW
Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee 32306-4340, USA. levenson@neuro.fsu.edu
D000818:Animals; D001927:Brain Diseases / Q000378:metabolism; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism*; D019587:Dietary Supplements; D006801:Humans; D018696:Neuroprotective Agents / Q000008:administration & dosage* / Q000378:metabolism; D009498:Neurotoxins / Q000008:administration & dosage* / Q000378:metabolism; D015032:Zinc / Q000008:administration & dosage* / Q000378:metabolism*
D018696:Neuroprotective Agents; D009498:Neurotoxins; D015032:Zinc