title: Inflammatory bowel disease and endothelin-1: a review.
abstract: Inflammatory bowel disease (IBD) appears to be an inappropriate response to an antigen that leads to chronic inflammation rather than repair. This review looks at the role of endothelin-1 (ET-1) as a proinflammatory agent in IBD. ET-1 antagonists in animal models reduce the incidence and severity of IBD. These antagonists may be useful for treatment of IBD in humans.
authors.affiliation: School of Nursing and Health Studies, Georgetown University, Washington, DC 20057, USA. angerioa@georgetown.edu
authors.forename: Allan D
authors.initials: AD
authors.lastname: Angerio
authors.forename: Dominick
authors.initials: D
authors.lastname: Bufalino
authors.forename: Melissa
authors.initials: M
authors.lastname: Bresnick
authors.forename: Christine
authors.initials: C
authors.lastname: Bell
authors.forename: Sarah
authors.initials: S
authors.lastname: Brill
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D019332:Endothelin-1 / Q000037:antagonists & inhibitors / Q000187:drug effects / Q000276:immunology*; D006801:Humans; D018928:Immunity, Mucosal / Q000187:drug effects / Q000276:immunology; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000276:immunology* / Q000503:physiopathology
chemical_list: D019332:Endothelin-1