Constituents of the leaves and twigs of Calyptranthes pallens collected from an experimental plot in Southern Florida.
Fractionation of the chloroform-soluble extract of the leaves and twigs of Calyptranthes pallens, collected from an experimental plot in a hardwood forest of southern Florida, using a hormone-dependent human prostate carcinoma (LNCaP) tumor cell line, led to the isolation of a phloroglucinol derivative with a novel carbon skeleton, pallenic acid (1), and a new triterpenoid, 3beta-hydroxy-18alpha,19alpha-urs-20-en-28-oic acid (2). The known compound methylene-bis-aspidinol (3) was selectively active against the human oral epidermoid carcinoma (KB) cell line. Several known compounds of the ellagic acid, lignan, phloroglucinol, sterol, and triterpene types were also obtained in the present investigation.
Lobo-Echeverri
Tatiana
T
Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA.
Rivero-Cruz
J Fausto
JF
Su
Bao-Ning
BN
Chai
Hee-Byung
HB
Cordell
Geoffrey A
GA
Pezzuto
John M
JM
Swanson
Steven M
SM
Soejarto
D Doel
DD
Kinghorn
A Douglas
AD
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005431:Florida; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure; D027822:Myrtaceae / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
C501036:3beta-hydroxy-18alpha,19alpha-urs-20-en-28-oic acid; D000972:Antineoplastic Agents, Phytogenic; D006575:Heterocyclic Compounds, 3-Ring; D014315:Triterpenes; C501035:pallenic acid