title: Pulmonary and renal function following cardiopulmonary bypass is associated with systemic capillary leak.
abstract: OBJECTIVE
  The purpose of this study was to compare perioperative capillary permeability during cardiac surgery with subsequent pulmonary and renal function.
  
  
  METHODS
  An observational prospective comparison of capillary permeability (microalbuminuria) during and after cardiopulmonary bypass (CPB), with postoperative pulmonary and renal function.
  
  
  METHODS
  A university teaching hospital.
  
  
  METHODS
  Forty patients, mean (range) age 67.8 (50-85) years, undergoing elective first-time coronary artery bypass grafting (CABG).
  
  
  METHODS
  Urine albumin concentration (AC) and albumin creatinine ratio (ACR) were compared with PO2 /FIO2 ratio, mechanical ventilation (intermittent positive-pressure ventilation [IPPV]) duration, and renal function.
  
  
  RESULTS
  Median (range) AC and ACR increased from 8.3 (1.6-184.2) mg/L and 0.65 (0.1-18.8) mg/mmol preoperatively to 13.6 (1.6-267.2) mg/L and 4.80 (0.3-54.2) mg/mmol 10 minutes postbypass (p = 0.003 for ACR Wilcoxon rank test: not significant for AC). AC 2 hours postbypass was associated with mean PO2 /FIO2 ratio 0 to 2 hours postbypass and AC 4 hours postbypass was associated with mean PO2 /FIO2 ratio 0 to 2 and 2 to 12 hours postbypass (p < 0.05 Spearman). ACR 2 hours postbypass was associated with mean PO2 /FIO2 ratio 0 to 2 and 2 to 12 hours postbypass (p < 0.05 Spearman). AC 10 minutes and 2 hours postbypass and ACR 2 hours postbypass were associated with the duration of IPPV (p < 0.03). Day 1 serum creatinine was associated with pre- and 4 hours postbypass AC and ACR (p < 0.05). Day 2 serum creatinine was associated with 2 and 4 hours postbypass ACR (p < 0.05).
  
  
  CONCLUSIONS
  The magnitude of increase in capillary permeability during CABG is associated with later pulmonary and renal function.
authors.affiliation: Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA. Charles.Brudney@Duke.edu
authors.forename: C Scott
authors.initials: CS
authors.lastname: Brudney
authors.forename: Peter
authors.initials: P
authors.lastname: Gosling
authors.forename: Mav
authors.initials: M
authors.lastname: Manji
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000419:Albuminuria / Q000378:metabolism; D015415:Biomarkers; D019559:Capillary Leak Syndrome / Q000503:physiopathology*; D002199:Capillary Permeability / Q000502:physiology; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D011184:Postoperative Period; D012121:Respiration, Artificial; D012129:Respiratory Function Tests
chemical_list: D015415:Biomarkers