[Comparative genomic hybridization: the profile of chromosomal imbalances in esophageal squamous cell carcinoma].
OBJECTIVE
To characterize the profile of chromosomal imbalances of esophageal squamous cell carcinoma (SCC) in Linzhou, the high prevalence area of Henan province.


METHODS
Comparative genomic hybridization (CGH) was used to examine 52 cases of primary SCC of esophagus.


RESULTS
Gains in part or in whole of chromosome 3q, 8q, 5p, 1q, 6q, 18p, 20q and losses of 3p, 1p, 9q, 19p, 4p, 8p were detected frequently in SCC (> 20%). Gain of 3q, 5p, 1q, 11q13-14 and loss of 4pq, 13q were all significantly correlated with pathologic staging (P < 0.05). Gains of 8q, loss of 4p were linked to nodal metastasis (P < 0.05). Gains of 2p and loss of 4pq, 11q14-qter were associated with distant organ metastasis (P < 0.05).


CONCLUSIONS
These observations suggest that 3q, 8q, 5p, 1q, 6q, 18p, and 20q may contain SCC-related oncogenes; 3p, 1p, 9q, 19p, 4p and 8p may contain SCC-related tumor suppressor genes. It is likely that gain of 3q, 5p, 1q, 11q13-14 and loss of 4pq, 13q are the genetic aberrations critical for the development of esophageal carcinoma, whereas gains of 8q, 2p and loss of 4pq, 11q14-qter are considered later events associated with tumor progression and are thought to confer metastatic potential to esophageal carcinoma. Furthermore, nodal and distant organ metastases involve different genes.
Qin
Yan-Ru
YR
Laboratory for Cancer Research, College of Medicine, Zhengzhou University, Zhengzhou 450052, China. lidong0823@sina.com
Wang
Li-Dong
LD
Kwong
Dora
D
Gao
Shan-Shan
SS
Guan
Xin-Yuan
XY
Zhuang
Ze-Hao
ZH
Fan
Zong-Min
ZM
Deng
Wen
W
Hu
Liang
L
D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002893:Chromosomes, Human, Pair 3; D002894:Chromosomes, Human, Pair 4; D002898:Chromosomes, Human, Pair 8; D004938:Esophageal Neoplasms / Q000235:genetics*; D005784:Gene Amplification; D006801:Humans; D008207:Lymphatic Metastasis; D009362:Neoplasm Metastasis / Q000235:genetics; D009367:Neoplasm Staging; D009693:Nucleic Acid Hybridization