title: A microfluidic mixer with grooves placed on the top and bottom of the channel.
abstract: A new microfluidic mixer is presented consisting of a rectangular channel with grooves placed in the top and bottom. This not only increases the driving force behind the lateral flow, but allows for the formation of advection patterns that cannot be created with structures on the bottom alone. Chevrons, pointing in opposite directions on the top and bottom, are used to create a pair of vortices positioned side by side. Stripes running the width of the channel generate a pair of vertically stacked vortices. Computational fluid dynamics (CFD) simulations are used to model the behavior of the systems and provide velocity maps at cross-sections within the mixer. Experiments demonstrate the mixing that results when two segregated species enter the mixer side-by-side and pass through two cycles of the mixer (i.e., two alternating sets of four stripes and four chevrons).
authors.affiliation: Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington DC, 20375-5348, USA.
authors.forename: Peter B
authors.initials: PB
authors.lastname: Howell
authors.forename: David R
authors.initials: DR
authors.lastname: Mott
authors.forename: Stephanie
authors.initials: S
authors.lastname: Fertig
authors.forename: Carolyn R
authors.initials: CR
authors.lastname: Kaplan
authors.forename: Joel P
authors.initials: JP
authors.lastname: Golden
authors.forename: Elaine S
authors.initials: ES
authors.lastname: Oran
authors.forename: Frances S
authors.initials: FS
authors.lastname: Ligler
mesh_terms: D003198:Computer Simulation; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation / Q000379:methods; D044085:Microfluidics / Q000295:instrumentation* / Q000379:methods*; D019904:Polymethyl Methacrylate / Q000737:chemistry; D012680:Sensitivity and Specificity; D013499:Surface Properties
chemical_list: D019904:Polymethyl Methacrylate