[Ductal regeneration in vanishing bile duct syndrome in Hodgkin's lymphoma].
We present the case of a 17-year-old male patient with Hodgkin's lymphoma (nodular sclerosis) in the mediastinum. During the postoperative period treatment with erythromycin was started and the patient developed progressive jaundice and cholestasis. Treatment modified for the lymphoma was initiated, which achieved complete remission and subsequent improvement and resolution of the cholestasis. Histological study of the liver revealed massive loss of bile ducts. After resolution of the cholestasis, consecutive biopsies revealed ductal proliferation. The present report therefore illustrates a case of ductopenia or vanishing bile duct syndrome (VBDS) with ad integrum regeneration of the bile ducts simultaneous with lymphoma remission. Because the 2 possible causes, erythromycin toxicity and Hodgkin's lymphoma, occurred simultaneously, the etiology of the VBDS cannot be definitively established.
Córdoba Iturriagagoitia
A
A
Servicio de Anatomía Patológica, Hospital de Navarra, Pamplona, Navarra, Spain. acordobi@cfnavarra.es
Iñarrairaegui Bastarrica
M
M
Pérez de Equiza
E
E
Zozaya Urmeneta
J M
JM
Martínez-Peñuela
J M
JM
Beloqui Pérez
R
R
D000293:Adolescent; D001652:Bile Ducts / Q000473:pathology / Q000502:physiology*; D006689:Hodgkin Disease / Q000150:complications* / Q000628:therapy*; D006801:Humans; D008297:Male; D012038:Regeneration