Successful recovery from interstitial pneumonitis, induced by bicalutamide and leuprorelin acetate given as treatment for prostate cancer.
We report a case of interstitial pneumonitis induced by bicalutamide and/or leuprorelin acetate given as therapy for prostate cancer, in which the pneumonitis was successfully managed by steroid treatment. Steroids were given promptly on the day following onset of pneumonitis, and the patient (72 years old) recovered almost completely within one and a half months. Interstitial pneumonitis, induced by hormone treatment given for prostate cancer, is a reversible condition and a quick diagnosis followed by prompt, proper treatment is important to ensure a successful recovery. The patient had been free of interstitial pneumonitis for 14 months, but died of pneumothorax.
Shioi
Koichi
K
Department of Urology, Yokosuka Hokubu Kyosai Hospital.
Sakai
Naoki
N
Yoshida
Minoru
M
Nakamura
Masafumi
M
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary; D000368:Aged; D000813:Anilides / Q000009:adverse effects; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects*; D001859:Bone Neoplasms / Q000556:secondary; D006801:Humans; D016729:Leuprolide / Q000009:adverse effects; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000188:drug therapy; D008297:Male; D008776:Methylprednisolone Hemisuccinate / Q000627:therapeutic use; D009570:Nitriles; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014105:Tosyl Compounds
D000813:Anilides; D000893:Anti-Inflammatory Agents; D018931:Antineoplastic Agents, Hormonal; D009570:Nitriles; D014105:Tosyl Compounds; D008776:Methylprednisolone Hemisuccinate; C053541:bicalutamide; D016729:Leuprolide