[Expression of SSX2 gene in human urologic neoplasms].
OBJECTIVE
To investigate the expression of SSX(2)gene in human renal cell carcinoma and urinary transitional cell carcinoma.


METHODS
Reverse-transcription polymerase chain reaction (RT-PCR) was used for detecting SSX(2) gene in the specimens from renal cell carcinoma (n = 26), urinary transitional cell carcinoma (n = 27) and in 15 specimens taken from the tumor surrounding tissues.


RESULTS
Positive expression of SSX(2) gene at mRNA was detected in 69% renal cell carcinomas (18/26), in 81% urinary transitional cell carcinomas (22/27). The mRNA of SSX(2) was not detected in the 15 specimens from tumor surrounding tissues.


CONCLUSIONS
The SSX(2) gene is highly expressed in human renal cell carcinoma and urinary transitional cell carcinoma.
Du
Peng
P
Department of Urology, The First Hospital of Peking University, Institute of Urology, Peking University, Beijing 100034, China. lihanDP@yahoo.com.cn
Yu
Li-zhang
LZ
Ma
Ming
M
Geng
Lin
L
Wang
Xiao-song
XS
Xin
Dian-qi
DQ
Na
Yan-qun
YQ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000473:pathology; D002295:Carcinoma, Transitional Cell / Q000235:genetics* / Q000473:pathology; D005260:Female; D015870:Gene Expression; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014523:Urethral Neoplasms / Q000235:genetics* / Q000473:pathology
D009363:Neoplasm Proteins; D012333:RNA, Messenger; D012097:Repressor Proteins; C093962:synovial sarcoma X breakpoint proteins