title: Hybrid nanocapsules: interactions of ABA block copolymers with liposomes.
abstract: Amphiphilic ABA triblock copolymers, such as poly(2-methyloxazoline)-block-poly(dimethylsiloxan)-block-poly(2-methyloxazoline) (PMOXA-PDMS-PMOXA), form vesicular structures. Here, the interaction of these ABA molecules with lipids is investigated by electron microscopy, fluorescence spectroscopy, light scattering, and differential scanning calorimetry. Our observations suggest the formation of homogeneous mixed polymer-lipid composites, independent of preparation method, i.e. film hydration, dispersion, or detergent removal. When ABA polymersomes and liposomes are mixed, we observed monomer exchanges on a time scale of minutes. The possibility of forming mixed structures and the exchanges between preformed structures allow the combination of the properties of lipids and polymers such as stability and loading encapsulation capacity.
authors.affiliation: Groupe de Biotechnologie des Protéines, Institut de Pharmacologie et de Biologie Structurale, 31077, Toulouse, France.
authors.forename: Tristan
authors.initials: T
authors.lastname: Ruysschaert
authors.forename: Andreas F P
authors.initials: AF
authors.lastname: Sonnen
authors.forename: Thomas
authors.initials: T
authors.lastname: Haefele
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Meier
authors.forename: Mathias
authors.initials: M
authors.lastname: Winterhalter
authors.forename: Didier
authors.initials: D
authors.lastname: Fournier
mesh_terms: D002152:Calorimetry, Differential Scanning; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D031541:Fluorescence Resonance Energy Transfer; D008027:Light; D008055:Lipids / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry*; D010080:Oxazoles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012542:Scattering, Radiation
chemical_list: D004129:Dimethylpolysiloxanes; D008055:Lipids; D008081:Liposomes; D010080:Oxazoles; D011108:Polymers