title: Residues in the murine leukemia virus capsid that differentially govern resistance to mouse Fv1 and human Ref1 restrictions.
abstract: We identified new residues within a 101-amino-acid stretch of the murine leukemia virus capsid that differentially modulate resistance and susceptibility to the mouse Fv1 and human Ref1 genes. Among these residues, aspartate 92 and histidine 117 are both required for Fv1(b) resistance, whereas the latter is sufficient to confer Ref1 resistance.
authors.affiliation: IGMM, CNRS-UMR5535, IFR122, 1919 Rte de Mende, F-34293 Montpellier Cedex 5, France.
authors.forename: Adeline
authors.initials: A
authors.lastname: Lassaux
authors.forename: Marc
authors.initials: M
authors.lastname: Sitbon
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Battini
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D036022:Capsid Proteins / Q000737:chemistry / Q000235:genetics*; D002460:Cell Line; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase / Q000235:genetics*; D005814:Genes, Viral / Q000235:genetics; D006801:Humans; D009052:Leukemia Virus, Murine / Q000235:genetics*; D051379:Mice; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics*; D015183:Restriction Mapping; D012192:Retroviridae Infections / Q000821:virology*; D016415:Sequence Alignment; D014162:Transfection; D014412:Tumor Virus Infections / Q000821:virology*
chemical_list: D036022:Capsid Proteins; C103189:Fv1 protein, mouse; D011506:Proteins; C085108:APEX1 protein, human; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase