title: Intramolecular hydroamination of unactived olefins with Ti(NMe2)4 as a precatalyst.
abstract: Commercially available Ti(NMe(2))(4) has been used effectively as a precatalyst in a facile protocol for the intramolecular hydroamination of aminoalkenes to yield pyrrolidine and piperidine heterocyclic products with isolated yields up to 92%. Geminally substituted substrates display the highest reactivity. This precatalyst is also effective for the hydroamination of activated internal alkenes, providing access to more complex heterocyclic target molecules.
authors.affiliation: Department of Chemistry, University of British Columbia, Vancouver, Canada.
authors.forename: Jason A
authors.initials: JA
authors.lastname: Bexrud
authors.forename: J David
authors.initials: JD
authors.lastname: Beard
authors.forename: David C
authors.initials: DC
authors.lastname: Leitch
authors.forename: Laurel L
authors.initials: LL
authors.lastname: Schafer