Anti-babesial and anti-plasmodial compounds from Phyllanthus niruri.
Bioassay-guided fractionation of boiled aqueous extracts from the whole plant of Phyllanthus niruri led to the isolation of 1-O-galloyl-6-O-luteoyl-alpha-d-glucose (1), with IC(50) values of 4.7 microg/mL against Babesia gibsoni and 1.4 microg/mL against Plasmodium falciparum in vitro. The known compounds beta-glucogallin (2), quercetin 3-O-beta-d-glucopyranosyl-(2-->1)-O-beta-d-xylopyranoside (3), beta-sitosterol, and gallic acid were also isolated. Structures of these compounds were elucidated on the basis of their chemical and spectroscopic data.
Subeki
Subeki
S
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan.
Matsuura
Hideyuki
H
Takahashi
Kosaku
K
Yamasaki
Masahiro
M
Yamato
Osamu
O
Maede
Yoshimitsu
Y
Katakura
Ken
K
Kobayashi
Sumiko
S
Trimurningsih
Trimurningsih
T
Chairul
Chairul
C
Yoshihara
Teruhiko
T
D000818:Animals; D001403:Babesia / Q000187:drug effects*; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008401:Gas Chromatography-Mass Spectrometry; D005947:Glucose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007214:Indonesia; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D029803:Phyllanthus / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*
C500768:1-O-galloyl-6-O-luteoyl-alpha-D-glucose; D005960:Glucosides; D005707:Gallic Acid; D005947:Glucose