title: Long-term efficacy and safety of somatropin for adult growth hormone deficiency.
abstract: The beneficial effects of somatropin (growth hormone [GH] replacement therapy) in adults are now established. Long-term somatropin administration in GH-deficient adults improves body composition, muscle strength, quality of life, bone mass and density, and lipoprotein pattern. The extent to which somatropin therapy can also reduce cardiovascular morbidity and mortality in GH-deficient adults remains to be determined. By starting with a low dose of somatropin, which is gradually increased based on clinical response (body composition, well-being, and serum insulin-like growth factor-1 concentration), effective treatment can be achieved with a minimum of fluid-related adverse effects. Thorough long-term monitoring of glucose metabolism, cardiovascular measurements, and underlying pituitary disease, is, however, mandatory.
authors.affiliation: Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, Göteborg, Sweden. Johan.Svensson@medic.gu.se
authors.forename: Johan
authors.initials: J
authors.lastname: Svensson
authors.forename: Gudmundur
authors.initials: G
authors.lastname: Johannson
mesh_terms: D000328:Adult; D001161:Arteriosclerosis / Q000209:etiology / Q000517:prevention & control; D001696:Biomechanical Phenomena; D001823:Body Composition; D001842:Bone and Bones / Q000293:injuries / Q000378:metabolism; D050723:Fractures, Bone / Q000517:prevention & control; D006321:Heart / Q000187:drug effects; D006331:Heart Diseases / Q000139:chemically induced; D019382:Human Growth Hormone / Q000009:adverse effects / Q000172:deficiency* / Q000627:therapeutic use*; D006801:Humans; D007029:Hypothalamic Neoplasms / Q000139:chemically induced; D009026:Mortality; D018482:Muscle, Skeletal / Q000503:physiopathology; D009369:Neoplasms / Q000139:chemically induced; D010911:Pituitary Neoplasms / Q000139:chemically induced; D011788:Quality of Life
chemical_list: D019382:Human Growth Hormone