title: The C-cells: current concepts on normal histology and hyperplasia.
abstract: We describe the current concepts on the embryology, normal morphology and immunohistochemistry of a minor cell population of the thyroid, the C-cells. We also try to make delineation between the normal number of the C-cells and C-cell hyperplasia. The two types of C-cell hyperplasia, physiologic and neoplastic are defined and characterized from morphologic and genetic point of view. Their relation with thyroid pathology, especially with medullary thyroid carcinoma is discussed.
authors.affiliation: Histology Department, University of Medicine and Pharmacy, Târgu Mureş.
authors.forename: A
authors.initials: A
authors.lastname: Borda
authors.forename: N
authors.initials: N
authors.lastname: Berger
authors.forename: M
authors.initials: M
authors.lastname: Turcu
authors.forename: M
authors.initials: M
authors.lastname: Al Jaradi
authors.forename: S
authors.initials: S
authors.lastname: Vereş
mesh_terms: D002116:Calcitonin / Q000378:metabolism; D018276:Carcinoma, Medullary / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D013961:Thyroid Gland / Q000378:metabolism / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000196:embryology / Q000378:metabolism / Q000473:pathology*; D013967:Thyroiditis, Autoimmune / Q000378:metabolism / Q000473:pathology
chemical_list: D002116:Calcitonin