Synthesis and characterisation of novel nanospheres made from amphiphilic perfluoroalkylthio-beta-cyclodextrins.
This work describes the synthesis of new amphiphilic perfluorohexyl- and perfluorooctyl-propanethio-beta-cyclodextrins and the comparison of the ability of these molecules and alkyl analogue, nonanethio-beta-cyclodextrin to form nanospheres. Nanospheres were prepared using nanoprecipitation method (perfluoroalkylthio-beta-cyclodextrin in THF [0.11 x 10(-3)M], stirring rate 700rpm, addition of aqueous phase at 64 degrees C into organic phase at 50 degrees C). They were characterised by Photon Correlation Spectroscopy (PCS) and by electron microscopy (SEM and cryo-TEM). The nanospheres prepared from these new beta-cyclodextrin derivatives have an average size of 260nm, and appear to be spherical in cryo-TEM images. Whereas alkyl analogue forms polydisperse aggregates with sizes in the range 60-350nm.
Péroche
Sandrine
S
Université Claude Bernard Lyon 1, Laboratoire de Méthodologie de Synthèse et Molécules Bioactives, Villeurbanne Cedex, France.
Degobert
Ghania
G
Putaux
Jean-Luc
JL
Blanchin
Marie-Geneviève
MG
Fessi
Hatem
H
Parrot-Lopez
Hélène
H
D000478:Alkylation; D020285:Cryoelectron Microscopy; D004355:Drug Stability; D005079:Excipients; D005612:Freeze Drying; D009682:Magnetic Resonance Spectroscopy; D008863:Microspheres; D010316:Particle Size; D047392:beta-Cyclodextrins / Q000737:chemistry*
D005079:Excipients; D047392:beta-Cyclodextrins