Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones.
Design, new synthesis, structure-activity relationship studies and calcium receptor antagonist (calcilytic) properties of novel 3H-pyrimidin-4-ones are described.
Shcherbakova
Irina
I
Drug Discovery, NPS Pharmaceuticals, Inc., 383 Colorow Drive, Salt Lake City, UT 84108, USA. ishcherbakova@npsp.com
Huang
Guangfei
G
Geoffroy
Otto J
OJ
Nair
Satheesh K
SK
Swierczek
Krzysztof
K
Balandrin
Manuel F
MF
Fox
John
J
Heaton
William L
WL
Conklin
Rebecca L
RL
D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D044169:Receptors, Calcium-Sensing / Q000187:drug effects*; D013329:Structure-Activity Relationship
D011744:Pyrimidinones; D044169:Receptors, Calcium-Sensing