Immunogenetic association in patients with antineutrophil cytoplasmic antibodies (ANCA) from Mumbai, Maharashtra, India.
Considerable genetic evidence exit for ANCA-associated vasculitis and pathogenesis. HLA A and B alleles identified serologically from 84 ANCA-positive patients were compared with 101 controls. Further subtyping were done in the 27 "pauci-immune" vasculitis patients using the polymerase chain reaction based PCR-SSOP technique and compared with controls (67). The results revealed that HLA A1 (OR=4.00; p value 2.72E-05), B17 (OR=3.38; p value 0.0008) and HLA B40 (OR=2.74; p value 0.001) were significantly increased among ANCA-positive patients when compared with the controls. Further, the molecular subtypes A*0101 (OR=5.04; p value 0.0005), B*5801 (OR=4.47; p value 0.0002) and haplotype A*0101-B*5801 (OR=4.47; p value 0.0001) were significantly increased among the autoimmune patients. The study revealed that HLA A1, B17 and B40 alleles are associated in production of antineutrophil autoantibodies and A*0101-B*5801 haplotype is significantly associated with autoimmune diseases and they may be invariably involved in disease pathogenesis in India.
Shankarkumar
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U
Institute of Immunohaematology (ICMR), 13th Floor, K.E.M. Hospital, Parel, Mumbai 400012, Maharashtra, India. shankarkumar16@hotmail.com
Ghosh
K
K
Pradhan
V D
VD
Badakere
S S
SS
Mohanty
D
D
D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood* / Q000235:genetics; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology; D015788:HLA-A1 Antigen / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D059947:HLA-B40 Antigen; D006801:Humans; D007125:Immunogenetics; D007194:India; D007918:Leprosy / Q000235:genetics / Q000276:immunology; D008288:Malaria / Q000235:genetics / Q000276:immunology; D014657:Vasculitis / Q000235:genetics / Q000276:immunology
D019268:Antibodies, Antineutrophil Cytoplasmic; D015788:HLA-A1 Antigen; D015235:HLA-B Antigens; C037449:HLA-B17 antigen; D059947:HLA-B40 Antigen