Synthesis of cis-fused carbo-bicycles by domino enyne cross-metathesis/intramolecular Diels-Alder Reaction.
A sequential combination of Ru-catalyzed enyne cross-metathesis (EYCM) and intramolecular Diels-Alder reaction (IMDA) is described. Different terminal alkynes and alpha,omega-dienes obtained by a Baylis-Hillman reaction were transformed into substituted cis-hexahydro-1H-indenes and cis-hexahydro-2H-naphthalin-1-ones.
Mix
Stefan
S
Institut für Chemie, Technische Universität Berlin, Germany.
Blechert
Siegfried
S