Effect of nanoprecipitation on the physicochemical properties of low molecular weight poly(L-lactic acid) nanoparticles loaded with salbutamol sulphate and beclomethasone dipropionate.
A modified nanoprecipitation (interfacial polymer deposition following solvent displacement) method was used to produce nanoparticles from low molecular weight poly(L-lactic acid). Model drugs, either salbutamol sulphate or beclomethasone dipropionate, were encapsulated in the particles. The influence of the preparation method on the physicochemical state of the polymer and the drugs as well as on the drug-polymer interactions were studied by electron microscopy, X-ray diffractometry, thermal analysis and infrared spectroscopy. Nanoprecipitation lowered the crystallinity of the PLA polymer. The crystallinity of the polymer was higher in the particles containing salbutamol sulphate then those containing beclomethasone dipropionate. The crystal form of beclomethasone dipropionate was changed from an anhydrate to a monohydrate as a result of nanoprecipitation. Although changes in the crystallinity of the polymer and the model drugs were seen, no clear interactions between the polymer and the drug were detected.
Hyvönen
S
S
Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, FIN-00014, Finland. samuli.hyvonen@helsinki.fi
Peltonen
L
L
Karjalainen
M
M
Hirvonen
J
J
D000420:Albuterol / Q000008:administration & dosage* / Q000737:chemistry; D001507:Beclomethasone / Q000008:administration & dosage* / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D011232:Chemical Precipitation; D019344:Lactic Acid / Q000008:administration & dosage / Q000737:chemistry*; D008970:Molecular Weight; D049329:Nanostructures; D010316:Particle Size; D011091:Polyesters; D011108:Polymers / Q000008:administration & dosage / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D001507:Beclomethasone; D000420:Albuterol