title: Transcriptional regulation of endothelin.
abstract: Three isoforms of endothelin (ET) exist, ET-l, ET-2,and ET-3.Nucleotide sequences for the three human ET genes are highly conserved. ET-l exactly matches the sequence ofET originally isolated from the condi- tioned medium of cultured bovine aortic endothelial cells (BAECs)."All three forms have been found in vascular, neural, adrenal, and kidney tissue, but are expressed in different proportions. Endothelial cells ex- clusively produce ETAll three isoforms have different vasoconstrictive potencies but are otherwise quali- tatively similar. ET-2 is the most potent vasoconstrictor, followed by ET-l and ET.
authors.affiliation: Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: J T
authors.initials: JT
authors.lastname: Koo
authors.forename: M D
authors.initials: MD
authors.lastname: Sawyer
authors.forename: R J
authors.initials: RJ
authors.lastname: Powell
authors.forename: B E
authors.initials: BE
authors.lastname: Sumpio