Review Article: cerebrospinal fluid in human African trypanosomiasis: a key to diagnosis, therapeutic decision and post-treatment follow-up.
Human African trypanosomiasis is a lethal parasitic infection with neurological involvement. Examination of the cerebrospinal fluid (CSF) plays an essential role in diagnosis, selection of treatment and post-treatment follow-up. This paper reviews clinical presentation, diagnosis and treatment of the disease, with emphasis on CSF characteristics and interpretation of the CSF results for therapeutic decision and post-treatment follow-up.
Lejon
V
V
Department of Parasitology, Institute of Tropical Medicine, Antwerpen, Belgium. vlejon@itg.be
Büscher
P
P
D000818:Animals; D002494:Central Nervous System Infections / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000188:drug therapy; D003657:Decision Making; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D014347:Trypanosoma brucei gambiense / Q000302:isolation & purification; D016833:Trypanosoma brucei rhodesiense / Q000302:isolation & purification; D014353:Trypanosomiasis, African / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000188:drug therapy
D007136:Immunoglobulins