Dynamic optical imaging.
The main direction in modern imaging is increasing the spatial resolution and selectivity for pathology
pattern recognition at the microscale. Dynamic optical imaging (DOl) has enormous potential in the selectivity
of description of living tissue state at cellular and subcellular levels. However, multiple light
scattering creates considerable difficulties in revealing the tissue microstructure in its depth. On the other
hand, along with changes in the microstructure, pathology should also manifest itself in the integral macroscopic
pattern of the tissue. Actually, living tissue, as a distributed active media with well-developed reception
and self-regulation, is characterized by a high spatial synergy. In such a media, even morphologically
small pathology could disturb tissue functioning in a rather extended area. As a result, after some definite
time, a diffuse "field" of the pathological phenomena appears even in the morphological image. Since optical
contrast is determined by tissue components (such as blood), which actively participate in physiological functioning,
the distributed functional pattern of the tissue is reflected in optical images in the form of spatiotemporal
modulation of the optical density. This observation opens up the possibility of investigating the diffuse
pattern of the pathology at the functional stage of its development, even before the actual appearance of
noticeable morphological changes .
Godik
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E
Dynamics Imaging, Inc., Washington Township, NJ, USA.
Gergely
T
T
Liger
V
V
Zlatov
V
V
Taratorin
A
A