title: Training nonhuman primates to perform behaviors useful in biomedical research.
abstract: Data collected from NHPs that are trained to participate voluntarily in husbandry, veterinary, and research procedures are likely to have particular value. The authors present the results of a series of studies that examined the effects of PRT on the performance by chimpanzees of a variety of biomedically relevant behaviors: presenting their perineum for pinworm testing, providing a semen sample, presenting for an s.c. injection, and presenting for an i.m. injection. The overall trends across studies indicate that PRT techniques have significant value in the handling and management of NHPs in many laboratory research settings, including less variability in the data collected and fewer potential confounding variables, which should lead to important refinements in the definition of NHPs as biomedical research models.
authors.affiliation: Michale E. Keeling Center for Comparative Medicine and Research, Department of Veterinary Sciences, The University of Texas M.D. Anderson Cancer Center, 650 Cool Water Dr., Bastrop, TX 78602. sschapir@mdanderson.org
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Schapiro
authors.forename: Jaine E
authors.initials: JE
authors.lastname: Perlman
authors.forename: Erica
authors.initials: E
authors.lastname: Thiele
authors.forename: Susan
authors.initials: S
authors.lastname: Lambeth
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D001522:Behavior, Animal / Q000502:physiology*; D003216:Conditioning, Operant; D007756:Laboratory Animal Science / Q000379:methods*; D002679:Pan troglodytes / Q000502:physiology*; D012054:Reinforcement, Psychology; D013048:Specimen Handling / Q000662:veterinary*