title: Oral immunization of sows: anti-K88 antibodies in serum and milk of the sow and in serum of the piglets.
abstract: Pregnant sows were immunized by oral application of live E. coli. The effect of immunization was demonstrated by measuring the titers of anti-K88 antibodies in sow serum, colostrum and milk as well as in piglet sera using enzyme-linked immunosorbent assays. The isotype involved in anti-K88 reactivity was found to be IgA. By comparing IgA-titers in colostrum and milk, the local production of this Ig-class in the mammary gland is suggested.
authors.affiliation: Departments of Immunology resp Bacteriology, Faculty of Veterinary Medicine, State University Utrecht, the Netherlands.
authors.forename: N
authors.initials: N
authors.lastname: Kortbeek-Jacobs
authors.forename: M
authors.initials: M
authors.lastname: van Houten
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn; D000907:Antibodies, Bacterial / Q000096:biosynthesis* / Q000097:blood; D000942:Antigens, Bacterial / Q000276:immunology*; D003126:Colostrum / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D004926:Escherichia coli / Q000276:immunology*; D004927:Escherichia coli Infections / Q000517:prevention & control / Q000662:veterinary; D029968:Escherichia coli Proteins / Q000276:immunology*; D005260:Female; D036781:Fimbriae Proteins / Q000276:immunology*; D007070:Immunoglobulin A / Q000096:biosynthesis* / Q000097:blood; D008892:Milk / Q000276:immunology; D011247:Pregnancy; D013552:Swine / Q000097:blood / Q000276:immunology*; D013553:Swine Diseases / Q000517:prevention & control; D014611:Vaccination / Q000662:veterinary*
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D029968:Escherichia coli Proteins; D007070:Immunoglobulin A; C026888:K88 antigen, E coli; D036781:Fimbriae Proteins