title: Metastases to the brain: current management perspectives.
abstract: Brain metastases are ten-times more common than primary brain tumors and are a common complication in patients with systemic cancer. The most common sources of brain metastases are lung and breast cancers, although in 15% of patients, the primary site is unknown. Optimal treatment is dependant upon tumor location, size, number of tumors and status of the systemic disease. Currently, management of brain metastases with surgery, radiotherapy and stereotactic radiosurgery is known to improve the quality of life and even life expectancy for selected patients. Techniques under investigation include focal radiation techniques, magnetic resonance imaging guided thermal ablation of metastases, drug delivery modes that bypass the blood-brain barrier and novel drug and molecular therapeutics. Efforts are ongoing to understand the molecular biology of brain metastases.
authors.affiliation: Brain Tumor Institute, Department of Neurosurgery, Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, Ohio, USA. nathoon@ccf.org
authors.forename: Narendra
authors.initials: N
authors.lastname: Nathoo
authors.forename: Steven A
authors.initials: SA
authors.lastname: Toms
authors.forename: Gene H
authors.initials: GH
authors.lastname: Barnett
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy*; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000628:therapy; D009362:Neoplasm Metastasis / Q000175:diagnosis / Q000628:therapy
chemical_list: D000927:Anticonvulsants; D000970:Antineoplastic Agents