title: Trans-4-aminocrotonic acid (TACA), a potent agonist of GABA(A) and GABA(C) receptors, shows a proconvulsant action in the electroconvulsive threshold test in mice.
abstract: In the present study, we evaluated TACA (a potent agonist of GABA(A) and GABA(C) receptors) in the electroconvulsive threshold test in mice. Surprisingly, TACA (at 15 and 25 mg/kg) significantly decreased the threshold. The highest ineffective dose of TACA was estimated as 10 mg/kg. The obtained results indicate that the drug enhancing GABAergic transmission may possess proconvulsant properties in the electroconvulsive test. Such effect was completely opposite to our primary assumption and expectance.
authors.affiliation: Department of Pathophysiology, Skubiszewski Medical University, Jaczewskiego 8, PL 20-090 Lublin, Poland. kornel@asklepios.am.lublin.pl
authors.forename: Kinga K
authors.initials: KK
authors.lastname: Borowicz
authors.forename: Marek
authors.initials: M
authors.lastname: Zadrozniak
authors.forename: Stanisław J
authors.initials: SJ
authors.lastname: Czuczwar
mesh_terms: D000818:Animals; D003437:Crotonates / Q000633:toxicity; D004597:Electroshock; D018755:GABA Agonists / Q000494:pharmacology*; D008297:Male; D051379:Mice; D012640:Seizures / Q000139:chemically induced*
chemical_list: D003437:Crotonates; D018755:GABA Agonists; C055331:4-aminocrotonic acid