The RUNX genes: gain or loss of function in cancer.
The RUNX genes have come to prominence recently because of their roles as essential regulators of cell fate in development and their paradoxical effects in cancer, in which they can function either as tumour-suppressor genes or dominant oncogenes according to context. How can this family of transcription factors have such an ambiguous role in cancer? How and where do these genes impinge on the pathways that regulate growth control and differentiation? And what is the evidence for a wider role for the RUNX genes in non-haematopoietic cancers?
Blyth
Karen
K
Molecular Oncology Laboratory, Institute of Comparative Medicine, University of Glasgow Veterinary School, Glasgow, G61 1QH, UK.
Cameron
Ewan R
ER
Neil
James C
JC
D000818:Animals; D050657:Core Binding Factor alpha Subunits; D004268:DNA-Binding Proteins / Q000235:genetics; D016147:Genes, Tumor Suppressor; D006801:Humans; D007938:Leukemia / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D009154:Mutation; D009363:Neoplasm Proteins / Q000737:chemistry / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D009857:Oncogenes; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics*; D014158:Transcription, Genetic; D016212:Transforming Growth Factor beta / Q000502:physiology; D014178:Translocation, Genetic
D050657:Core Binding Factor alpha Subunits; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; D014157:Transcription Factors; D016212:Transforming Growth Factor beta