Association mapping and fine mapping with TreeLD.
The program package TreeLD implements a unified approach to association mapping and fine mapping of complex trait loci and a novel approach to visualizing association data, based on an inferred ancestry of the sample. Fundamentally, the TreeLD approach is based on the idea that the evidence for association at a particular position is contained in the ancestral tree relating the sampled chromosomes at that position. TreeLD provides an easy-to-use interface and can be applied to case-control, TDT trio and quantitative trait data.
Zöllner
Sebastian
S
Department of Human Genetics, The University of Chicago 920 East 58th Street-CLSC 507, Chicago, IL 60637, USA. szoellne@genetics.bsd.uchicago.edu
Wen
Xiaoquan
X
Pritchard
Jonathan K
JK
D000465:Algorithms; D002874:Chromosome Mapping / Q000379:methods*; D003196:Computer Graphics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D040641:Quantitative Trait Loci / Q000235:genetics*; D017422:Sequence Analysis, DNA / Q000379:methods; D012984:Software; D014584:User-Computer Interface