title: Effects of zinc deficiency and supplementation on plasma leptin levels in rats.
abstract: The effects of zinc deficiency and supplementation on plasma leptin levels were studied in Sprague-Dawley rats. After 6 wk on a zinc-deficient diet containing 0.65 ppm Zn/g, the mean body weight was significantly lower than that of normal or zinc-supplemented rats, which showed no difference among them. The plasma leptin and zinc levels were lowest in zinc-deficient animals and highest in those that received a normal diet and daily intraperitioneal injections of 3 mg Zn/kg. These results indicate that zinc deficiency leads to a significant inhibition in plasma leptin levels, whereas zinc supplementation significantly increases plasma leptin.
authors.affiliation: Department of Physiology, Meram Medical School, Selcuk University, Konya, Turkey.
authors.forename: Abdulkerim Kasim
authors.initials: AK
authors.lastname: Baltaci
authors.forename: Rasim
authors.initials: R
authors.lastname: Mogulkoc
authors.forename: Ihsan
authors.initials: I
authors.lastname: Halifeoglu
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D020738:Leptin / Q000097:blood*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D015032:Zinc / Q000097:blood / Q000172:deficiency* / Q000494:pharmacology*
chemical_list: D020738:Leptin; D015032:Zinc