title: Angiosarcoma after breast-conserving therapy: fine-needle aspiration biopsy, immunocytochemistry, and clinicopathologic correlates.
abstract: BACKGROUND
  Angiosarcoma that arises after breast-conserving therapy can present clinically as a cutaneous and/or subcutaneous breast lump, which is misinterpreted easily as a recurrence of carcinoma. To the authors' knowledge, the role of fine-needle aspiration (FNA) cytology in the early diagnosis of this life-threatening complication of breast carcinoma therapy has not been established fully.
  
  
  METHODS
  The authors studied three new patients with this type of secondary angiosarcoma diagnosed by FNA biopsy and immunocytochemistry, reviewed the literature on the topic, and examined relevant differential diagnostic issues.
  
  
  RESULTS
  Patients presented with a discrete skin lump that had arisen several years after breast-conservative therapy for early-stage breast carcinoma near the scar from the previous surgery. The lesions were interpreted clinically as recurrent carcinoma. FNA yielded moderately cellular to highly cellular samples with variable patterns of cellular aggregation. Cells were epithelioid and spindle-shaped. Angioformative changes were subtle, and the overall picture suggested an epithelial malignancy, possibly a metaplastic carcinoma. Immunostaining of smears, however, provided conclusive evidence of the endothelial differentiation of tumor cells, and an FNA diagnosis of angiosarcoma was rendered in all patients. The histopathology of all surgically excised tumors confirmed the diagnosis of high-grade angiosarcoma.
  
  
  CONCLUSIONS
  Based on the authors' experience, the FNA cytologic appearance of angiosarcoma that presented as a breast skin nodule in a breast carcinoma survivor easily could have been misinterpreted as carcinoma. A correct diagnosis of this tumor relies on the proper evaluation of clinical findings and, as also shown by a review of the literature, requires immunocytochemical evidence of endothelial differentiation.
authors.affiliation: Department of Pathology, Fatebenefratelli Hospital, Milan, Italy. giorgio.gherardi@fbf.milano.it
authors.forename: Giorgio
authors.initials: G
authors.lastname: Gherardi
authors.forename: Stefania
authors.initials: S
authors.lastname: Rossi
authors.forename: Silvia
authors.initials: S
authors.lastname: Perrone
authors.forename: Alberto
authors.initials: A
authors.lastname: Scanni
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery*; D002278:Carcinoma in Situ / Q000473:pathology / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000556:secondary / Q000601:surgery; D018275:Carcinoma, Lobular / Q000556:secondary / Q000601:surgery; D005260:Female; D006394:Hemangiosarcoma / Q000556:secondary* / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D015412:Mastectomy, Segmental / Q000009:adverse effects* / Q000379:methods; D009367:Neoplasm Staging; D011379:Prognosis; D018570:Risk Assessment; D012494:Sampling Studies; D012680:Sensitivity and Specificity; D012878:Skin Neoplasms / Q000556:secondary* / Q000628:therapy; D015996:Survival Rate