title: Lymphangitis-associated rickettsiosis, a new rickettsiosis caused by Rickettsia sibirica mongolotimonae: seven new cases and review of the literature.
abstract: BACKGROUND
  Rickettsia sibirica mongolotimonae has been found in Hyalomma ticks in Inner Mongolia (in China) and Niger and in humans in France and South Africa. To date, only 3 cases of human infection have been reported.
  
  
  METHODS
  Patients received a diagnosis of R. sibirica mongolotimonae infection on the basis of culture and/or PCR results plus serological test results.
  
  
  RESULTS
  From January 2000 to June 2004, R. sibirica mongolotimonae infection was diagnosed in 7 patients. In 3 patients, the bacterium was cultivated from the inoculation eschar. The other 4 patients had cases that were diagnosed with use of PCR of samples obtained from the eschar (2 patients) or blood (2 patients), plus specific Western blot before (2 patients) and after (2 patients) cross-adsorption. The clinical presentation included fever (temperature, >38.5 degrees C), a maculopapular rash, and > or =1 inoculation eschar in 6 patients, enlarged regional lymph nodes in 4 patients, and lymphangitis in 3 patients. On the basis of the study of 9 cases, R. sibirica mongolotimonae infection differed from other tick-borne rickettsioses in the Mediterranean area in the following ways: it involved a specific incidence in the spring, the presence of 2 eschars in 2 (22%) of the patients, the presence of a draining lymph node in 5 (55%) of the patients, and lymphangitis expanding from the inoculation eschar to the draining node in 4 (44%) of the patients. The most recent patient in our series received a clinical diagnosis on the basis of such findings. All patients recovered without any sequelae.
  
  
  CONCLUSIONS
  We propose that this new rickettsiosis be named "lymphangitis-associated rickettsiosis." Lymphangitis-associated rickettsiosis should be considered in the differential diagnosis of tick-borne rickettsioses in Europe, Africa, and Asia.
authors.affiliation: Unité des Rickettsies, Université de la Méditerranée, Faculté de Médecine, Marseille, France.
authors.forename: Pierre-Edouard
authors.initials: PE
authors.lastname: Fournier
authors.forename: Frédérique
authors.initials: F
authors.lastname: Gouriet
authors.forename: Philippe
authors.initials: P
authors.lastname: Brouqui
authors.forename: Frédéric
authors.initials: F
authors.lastname: Lucht
authors.forename: Didier
authors.initials: D
authors.lastname: Raoult
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D005260:Female; D006801:Humans; D008205:Lymphangitis / Q000150:complications* / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D010802:Phylogeny; D012281:Rickettsia / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D012282:Rickettsia Infections / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology*; D013987:Ticks / Q000382:microbiology