title: In vivo assessment of postnatal murine ocular development by ultrasound biomicroscopy.
abstract: OBJECTIVE
  Ultrasound biomicroscopy (UBM) can noninvasively provide anatomical information about mouse ocular structures. We present the quantitation of postnatal murine eye development using UBM.
  
  
  METHODS
  The eyes from CD-1 mice were examined at 1, 2, 4, 6, and 8 weeks of postnatal development using 40 MHz UBM. Patterns of ocular tissue growth including the lens, globe, and anterior chamber were calculated.
  
  
  RESULTS
  Postnatal CD-1 lens and globe volumes are consistent with an exponential decay of growth during the first 8 postnatal weeks. Anterior chamber depth increases most sharply in the first 2 postnatal weeks but continues to increase up to the 8th postnatal week. Anterior segment angle was observed to increase from 1 to 4 weeks.
  
  
  CONCLUSIONS
  UBM can be used to obtain in vivo quantitative measurements of postnatal murine ocular structures. Our ability to obtain ocular anatomical information will facilitate future assessments of mouse models of human disease.
authors.affiliation: Department of Imaging Research, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada. Allison.Brown@swri.ca
authors.forename: Allison S
authors.initials: AS
authors.lastname: Brown
authors.forename: MingYu
authors.initials: M
authors.lastname: Zhang
authors.forename: Viviene
authors.initials: V
authors.lastname: Cucevic
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Pavlin
authors.forename: F Stuart
authors.initials: FS
authors.lastname: Foster
mesh_terms: D000818:Animals; D000867:Anterior Chamber / Q000000981:diagnostic imaging / Q000254:growth & development; D005123:Eye / Q000000981:diagnostic imaging* / Q000254:growth & development*; D007908:Lens, Crystalline / Q000000981:diagnostic imaging / Q000254:growth & development; D051379:Mice; D033401:Microscopy, Acoustic / Q000379:methods*; D009799:Ocular Physiological Phenomena; D009915:Orbit / Q000000981:diagnostic imaging / Q000254:growth & development