title: Retinopathy and hypertension affect serum high-sensitivity C-reactive protein levels in Type 2 diabetic patients.
abstract: Several studies suggest that inflammation plays an important role in the pathogenesis of diabetes mellitus, as well as atherosclerosis, and acute-phase reactants have been proposed as monitors for the ongoing process of these diseases. We studied the clinical significance of serum high-sensitivity C-reactive protein (hs-CRP) in relation to chronic diabetic complications using 114 Japanese patients with Type 2 diabetes mellitus. The hs-CRP values were normalized by logarithmic transformation for statistical analysis. Retinopathy and hypertension were extracted as significant modulators for the hs-CRP value in the diabetic patients, in addition to previously known factors, age, and body mass index (BMI), by multivariate analysis. The hs-CRP level in normotensive diabetic patients without retinopathy was not significantly different from that of normal control participants after adjustment for age and BMI. The hs-CRP value was significantly high in the patients with hypertension, despite the existence or absence of diabetes. On the other hand, the hs-CRP level of the diabetic patients complicated with retinopathy was low especially in those with hypertension. The frequency of patients having an hs-CRP value above 1.0 mg/l who are thought to be at risk for cardiovascular diseases was also high in the patients complicated with hypertension and low in the diabetic patients with retinopathy. These results indicate that the presence or absence of hypertension and retinopathy should be taken into consideration for the interpretation of the serum hs-CRP in diabetic patients.
authors.affiliation: Department of Clinical Laboratory Medicine, Faculty of Medicine, Wakayama Medical University, 811-1 Kimi-idera, Wakayama 641-8509, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Tsunoda
authors.forename: Mikio
authors.initials: M
authors.lastname: Arita
authors.forename: Mariko
authors.initials: M
authors.lastname: Yukawa
authors.forename: Minoru
authors.initials: M
authors.lastname: Ueyama
authors.forename: Machi
authors.initials: M
authors.lastname: Furuta
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Kishio
authors.initials: K
authors.lastname: Nanjo
authors.forename: Tokio
authors.initials: T
authors.lastname: Sanke
mesh_terms: D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003925:Diabetic Angiopathies / Q000097:blood*; D003930:Diabetic Retinopathy / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D007249:Inflammation; D007564:Japan; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein