Development of headspace solid-phase microextraction-gas chromatography method for the determination of solvent residues in edible oils and pharmaceuticals.
The application of headspace solid-phase microextraction for isolation and enrichment of solvent residues from oils and pharmaceuticals is discussed. The optimal parameters for isolation and preconcentration of common process solvents (hexane, benzene, toluene and selected chloroderivatives of hydrocarbons) were established. Four fiber types (100 microm polydimethylsiloxane (PDMS), 75 microm Carboxen-PDMS, 65 microm PDMS-divinylbenzene and 85 microm polyacrylate) were evaluated to choose the most efficient coating, able to absorb the greatest amount of analytes. GC-flame ionization detection (FID) and GC-electron-capture detection systems were used for quantitative and qualitative analysis, adequately to the appropriate group of the analytes. For all compounds the limit of detection (LOD), linearity, dynamic range, repeatability and intermediate precision were estimated.
Michulec
M
M
Department of Analytical Chemistry, Chemical Faculty, Gdansk University of Technology, 11/12 G. Narutowicza Str., 80-952 Gdańsk, Poland. magdalenamichulec@wp.pl
Wardencki
W
W
D002849:Chromatography, Gas / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010938:Plant Oils / Q000737:chemistry*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012997:Solvents / Q000032:analysis*; D013696:Temperature; D013995:Time
D004364:Pharmaceutical Preparations; D010938:Plant Oils; D012997:Solvents