title: c-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver.
abstract: The c-Myc protein is a transcription factor implicated in the regulation of multiple biological processes, including cell proliferation, cell growth, and apoptosis. In vivo overexpression of c-myc is linked to tumor development in a number of mouse models. Here, we show that perinatal inactivation of c-Myc in liver causes disorganized organ architecture, decreased hepatocyte size, and cell ploidy. Furthermore, c-Myc appears to have distinct roles in proliferation in liver. Thus, postnatal hepatocyte proliferation does not require c-Myc, whereas it is necessary for liver regeneration in adult mice. These results show novel physiological functions of c-myc in liver development and hepatocyte proliferation and growth.
authors.affiliation: Department of Immunology and Oncology, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Cantoblanco, E-28049 Madrid, Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: Baena
authors.forename: Alberto
authors.initials: A
authors.lastname: Gandarillas
authors.forename: Mireia
authors.initials: M
authors.lastname: Vallespinós
authors.forename: Jennifer
authors.initials: J
authors.lastname: Zanet
authors.forename: Oriol
authors.initials: O
authors.lastname: Bachs
authors.forename: Clara
authors.initials: C
authors.lastname: Redondo
authors.forename: Isabel
authors.initials: I
authors.lastname: Fabregat
authors.forename: Carlos
authors.initials: C
authors.lastname: Martinez-A
authors.forename: Ignacio Moreno
authors.initials: IM
authors.lastname: de Alborán
mesh_terms: D000818:Animals; D001973:Bromodeoxyuridine; D049109:Cell Proliferation; D048429:Cell Size; D017931:DNA Primers; D005452:Fluoresceins; D022781:Hepatocytes / Q000378:metabolism*; D007150:Immunohistochemistry; D008099:Liver / Q000254:growth & development / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D011003:Ploidies; D011070:Poly I-C; D016133:Polymerase Chain Reaction; D016271:Proto-Oncogene Proteins c-myc / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism*
chemical_list: D017931:DNA Primers; D005452:Fluoresceins; C489428:Myc protein, mouse; D016271:Proto-Oncogene Proteins c-myc; C029569:diacetyldichlorofluorescein; D001973:Bromodeoxyuridine; D011070:Poly I-C