title: N6-Arylation of 2'-deoxyadenosine via copper-catalyzed direct coupling with aryl halides.
abstract: [reaction: see text] A general method for efficient N(6)-arylation of 2'-deoxyadenosine via copper-catalyzed direct coupling with aryl iodides and bromides is described. The method is useful for aryl halides with either electron-donating or electron-withdrawing groups.
authors.affiliation: Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA.
authors.forename: Chongzhao
authors.initials: C
authors.lastname: Ran
authors.forename: Qing
authors.initials: Q
authors.lastname: Dai
authors.forename: Ronald G
authors.initials: RG
authors.lastname: Harvey
mesh_terms: D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D003300:Copper / Q000737:chemistry*; D003839:Deoxyadenosines / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D007202:Indicators and Reagents; D015394:Molecular Structure
chemical_list: D003839:Deoxyadenosines; D006846:Hydrocarbons, Halogenated; D007202:Indicators and Reagents; D003300:Copper