Inflammatory bowel disease and endothelin-1: a review.
Inflammatory bowel disease (IBD) appears to be an inappropriate response to an antigen that leads to chronic inflammation rather than repair. This review looks at the role of endothelin-1 (ET-1) as a proinflammatory agent in IBD. ET-1 antagonists in animal models reduce the incidence and severity of IBD. These antagonists may be useful for treatment of IBD in humans.
Angerio
Allan D
AD
School of Nursing and Health Studies, Georgetown University, Washington, DC 20057, USA. angerioa@georgetown.edu
Bufalino
Dominick
D
Bresnick
Melissa
M
Bell
Christine
C
Brill
Sarah
S
D000818:Animals; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D019332:Endothelin-1 / Q000037:antagonists & inhibitors / Q000187:drug effects / Q000276:immunology*; D006801:Humans; D018928:Immunity, Mucosal / Q000187:drug effects / Q000276:immunology; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000276:immunology* / Q000503:physiopathology
D019332:Endothelin-1