Simple automated preparation of O-[11C]methyl-l-tyrosine for routine clinical use.
The previously reported preparation of O-[(11)C]methyl-l-tyrosine ([(11)C]MT), a promising tumor imaging agent, has been now considerably simplified and automated. Main changes were the use of [(11)C]methyl iodide ([(11)C]MeI) in the reaction with l-tyrosine disodium and the use of solid phase extraction on commercially available cartridges instead of HPLC for the final purification. An injectable saline solution of [(11)C]MT was obtained within 30 min after EOB with radiochemical yield of ca. 60% (decay-corrected, based on [(11)C]MeI). Radiochemical purity was over 97%. The automated preparation was carried out using a miniature module employing manifold valves.
Ishikawa
Yoichi
Y
CYRIC Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578, Japan.
Iwata
Ren
R
Furumoto
Shozo
S
Pascali
Claudio
C
Bogni
Anna
A
Kubota
Kazuo
K
Ishiwata
Kiichi
K
D001331:Automation; D002250:Carbon Radioisotopes; D002851:Chromatography, High Pressure Liquid; D008781:Methyltyrosines; D019275:Radiopharmaceuticals
D002250:Carbon Radioisotopes; D008781:Methyltyrosines; D019275:Radiopharmaceuticals