[The expression of p73 and c-fos protein in hemangioma and its significance].
OBJECTIVE
To investigate the expression of p73 and c-fos protein and its significance in the development of children hemangioma.


METHODS
The quantitative expressions of p73 and c-fos protein in hemangioma and normal skin were detected by immunohistochemistry.


RESULTS
The expressions of p73 and c-fos protein were strong in proliferative hemangioma while they were very weak in involutional hemangioma and normal skin. There were significant differences between the proliferative and involutional hemangioma or the normal skin in the expressions of p73 and c-fos (P < 0.01). No statistical significances of p73 or c-fos P73 expressions were observed between involutional hemangioma and normal skin (P > 0.05).


CONCLUSIONS
P73 and c-fos may play an important role in the development and involution of skin hemangioma.
Chen
Zhi-xiong
ZX
The Department of Geriatrics, the People' s Hospital of Wuhan University, Wuhan 430060, China.
Shan
Sheng-guo
SG
Zhang
Duan-lian
DL
Liu
Juan
J
Yang
Yong
Y
D002648:Child; D002675:Child, Preschool; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005260:Female; D006391:Hemangioma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D016760:Proto-Oncogene Proteins c-fos; C000606460:TP73 protein, human; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins