Cremastrine, a pyrrolizidine alkaloid from Cremastra appendiculata.
A new pyrrolizidine alkaloid, cremastrine (1), was isolated from the bulbs of Cremastra appendiculata. Its configuration was determined by spectroscopic and chemical analyses. Compound 1 inhibited the binding of tritium-labeled N-methylscopolamine to the muscarinic M3 receptor with a K(i) value of 126 nM.
Ikeda
Yoshitaka
Y
Pharmaceuticals Research Unit, Mitsubishi Pharma Corporation, 2-25-1, Shodai-Ohtani, Hirakata, Osaka 573-1153, Japan. Ikeda.Yoshitaka@mc.m-pharma.co.jp
Nonaka
Hikaru
H
Furumai
Tamotsu
T
Igarashi
Yasuhiro
Y
D007564:Japan; D015394:Molecular Structure; D019832:N-Methylscopolamine / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D029595:Orchidaceae / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D011763:Pyrrolizidine Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000493:pharmacokinetics / Q000494:pharmacology; D043587:Receptor, Muscarinic M3 / Q000378:metabolism*
D011763:Pyrrolizidine Alkaloids; D043587:Receptor, Muscarinic M3; C500674:cremastrine; D019832:N-Methylscopolamine