title: Valdecoxib for the management of chronic and acute pain.
abstract: Cyclooxygenase-2 specific inhibitors have anti-inflammatory and analgesic properties, and are effective in managing a wide range of chronic and acute painful conditions such as adult rheumatoid arthritis, osteoarthritis, migraine, primary dysmenorrhea and postoperative pain. Valdecoxib, an orally administered cyclooxygenase-2 specific inhibitor, provides effective pain relief for both chronic and acute conditions, and reduces postoperative opioid use, with a concomitant reduction in opioid-related adverse events. Valdecoxib also has superior gastrointestinal safety compared with nonspecific nonsteroidal anti-inflammatory drugs, and at therapeutic doses, it is generally safe and well tolerated in terms of renal and cardiovascular events. This drug profile reviews the efficacy, safety and tolerability of valdecoxib for the management of chronic and acute pain.
authors.affiliation: Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9068, USA. girish.joshi@utsouthwestern.edu
authors.forename: Girish P
authors.initials: GP
authors.lastname: Joshi
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use; D000208:Acute Disease; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use*; D004341:Drug Evaluation; D005104:Expert Testimony; D006801:Humans; D007555:Isoxazoles / Q000627:therapeutic use*; D009294:Narcotics / Q000627:therapeutic use; D010146:Pain / Q000145:classification / Q000188:drug therapy*; D011358:Product Surveillance, Postmarketing; D013449:Sulfonamides / Q000627:therapeutic use*; D000096926:Benzenesulfonamides
chemical_list: D000082:Acetaminophen; D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D007555:Isoxazoles; D009294:Narcotics; D013449:Sulfonamides; C406224:valdecoxib; D000096926:Benzenesulfonamides