title: Endogenous endophthalmitis: a 13-year review at a tertiary hospital in South Australia.
abstract: This retrospective report presents a series of patients with endogenous endophthalmitis treated over a 13-y period in a tertiary care centre in South Australia. 16 eyes of 13 patients (8 M, 5 F) with a mean age 62 y were included. Systemic predisposing risk factors were mainly diabetes mellitus (30.7%), chronic obstructive airway disease (23.1%) and end-stage renal disease (15.4%). Isolated organisms included fungal species in 11 eyes (7 eyes with Candida albicans and 4 with Aspergillus fumigatus), Gram-positive isolates in 4 eyes, and Pseudomonas aeruginosa in 1 eyes. Presenting visual acuity was 20/200 or lower in 8 patients (61.5%). Final visual improvement of more than 2 lines was noted in 5 patients, it was stable or worse in 6 patients and in 2 patients the eye was either enucleated or eviscerated. Systemic aspergillosis resulted in death of both patients. In conclusion, the clinical course and microbiological profile of pathogens in patients with endogenous endophthalmitis in our series are similar to other recent western reports. Candida species are the leading isolates, with an overall poor visual prognosis, especially in Aspergillus infections. Close monitoring of immune-compromised patients with systemic infections may enable early diagnosis and treatment and improve prognosis.
authors.affiliation: Department of Ophthalmology, Royal Adelaide Hospital, University of Adelaide, South Australia. leiboigal5@yahoo.com.au
authors.forename: Igal
authors.initials: I
authors.lastname: Leibovitch
authors.forename: Tze
authors.initials: T
authors.lastname: Lai
authors.forename: Grant
authors.initials: G
authors.lastname: Raymond
authors.forename: Ramin
authors.initials: R
authors.lastname: Zadeh
authors.forename: Francis
authors.initials: F
authors.lastname: Nathan
authors.forename: Dinesh
authors.initials: D
authors.lastname: Selva
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001232:Aspergillus fumigatus / Q000302:isolation & purification; D002176:Candida albicans / Q000302:isolation & purification; D009877:Endophthalmitis / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology*; D015818:Eye Infections, Bacterial / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology*; D015821:Eye Infections, Fungal / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology*; D005260:Female; D006095:Gram-Positive Cocci / Q000187:drug effects / Q000302:isolation & purification; D006761:Hospitals; D006801:Humans; D008297:Male; D008875:Middle Aged; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000302:isolation & purification; D013021:South Australia; D014792:Visual Acuity; D014821:Vitrectomy