Glucose intolerance and all-cause mortality in Japanese migrants.
OBJECTIVE
To assess all-cause mortality in a Japanese-Brazilian community according to the categories of glucose tolerance.


METHODS
The cohort consisted of participants examined in two phases of a follow-up study started in 1993 (n=647). They were interviewed and submitted to an oral glucose tolerance test. Student's t-test was used to compare baseline parameters between alive and dead subjects. Cox proportional hazards model was used to estimate crude and adjusted hazard ratios (HR).


RESULTS
Seventy-one deaths occurred during the study period and a higher proportion of men (62%) was detected. Crude all-cause mortality rate was 16.2/1000 person-year. Vascular disease and cancer were the most frequent causes of deaths (77.3%). A higher mortality rate was observed in subjects with diabetes when compared with the normal glucose tolerant ones (HR: 2.0; 95% CI: 1.1-3.6), independently of age, systolic blood pressure, smoking and history of myocardial infarction.


CONCLUSIONS
Also among Japanese living in the Western world, a deleterious role of fasting and 2-h plasma glucose was found on mortality especially among younger subjects.
Gimeno
Suely G A
SG
Preventive Medicine Department, Federal University of São Paulo (UNIFESP-EPM), São Paulo, Brazil. suely@mdprev.epm.br
Osiro
Katsumi
K
Matsumura
Luisa
L
Massimino
Flávia Cicotto
FC
Ferreira
Sandra R G
SR
D000368:Aged; D044466:Asian People / Q000208:ethnology* / Q000706:statistics & numerical data; D001786:Blood Glucose / Q000032:analysis; D001938:Brazil / Q000208:ethnology; D002423:Cause of Death; D005260:Female; D005500:Follow-Up Studies; D018149:Glucose Intolerance / Q000150:complications / Q000175:diagnosis / Q000401:mortality*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors; D014171:Transients and Migrants
D001786:Blood Glucose