title: Solution conformations of amphidinolide H.
abstract: Solution conformations of amphidinolide H (1), a 26-membered macrolide exhibiting potent cytotoxic and antitumor activity, in CDCl3 and DMSO-d6 were investigated on the basis of NMR data, distance geometry calculation, and restrained energy minimization. Three-dimensional conformations in CDCl3 were suggested to be close to the X-ray structure of 1, while those in DMSO-d6 were indicated to be different from both those in CDCl3 and the X-ray structure.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Shimbo
authors.forename: Kohei
authors.initials: K
authors.lastname: Nozawa
authors.forename: Masashi
authors.initials: M
authors.lastname: Tsuda
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Kobayashi
mesh_terms: D018360:Crystallography, X-Ray; D018942:Macrolides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D012996:Solutions; D000097442:Amphidinolides
chemical_list: D018942:Macrolides; D012996:Solutions; C414664:amphidinolide H; D000097442:Amphidinolides