Whole-genome views of chromatin structure.
DNA in eukaryotes is packed into chromatin. The basic component of chromatin is the nucleosome consisting of DNA wrapped around a histone octamer. Inside the cell nucleus, chromatin is folded into higher-order structures through various mechanisms, including repositioning of nucleosomes along the DNA, packing of nucleosomes into more condensed 3-dimensional configurations, looping of chromatin fibres, and tethering of chromosomal regions to nuclear structures. Over the past few years, new microarray-based methods have been developed for the genome-wide mapping of various aspects of chromatin structure. These methods are beginning to provide insights into the different types of chromatin and the architectural principles that govern the 3-dimensional organisation of the genome inside the nucleus.
Lodén
Martin
M
Netherlands Cancer Institute, Amsterdam, 1066CX, The Netherlands.
van Steensel
Bas
B
D002467:Cell Nucleus / Q000737:chemistry; D002843:Chromatin / Q000737:chemistry* / Q000235:genetics*; D002874:Chromosome Mapping; D016678:Genome; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis
D002843:Chromatin