title: Developmental dyslexia--recurrence risk estimates from a german bi-center study using the single proband sib pair design.
abstract: OBJECTIVE
  Several studies have demonstrated a genetic component for dyslexia. However, both segregation and linkage analyses show contradictory results pointing at the necessity of an optimal ascertainment scheme for molecular genetic studies. Previously, we have argued that the single proband sib pair design (SPSP) would be optimal. The aims of this paper therefore are to demonstrate the practicability of the SPSP design and the estimation of recurrence risks for reading and writing.
  
  
  METHODS
  We assessed spelling and reading in a family sample ascertained through the SPSP design. 287 families with at least two siblings and their parents were recruited. At least one child was affected with spelling disorder according to a one standard deviation (1SD) discrepancy criterion.
  
  
  RESULTS
  Mean values for probands and their siblings were different for both the spelling and the reading phenotype. For the probands, variances of the phenotype spelling were smaller. These effects became stronger with more extreme selection criteria. Both siblings fulfilled the 1SD criterion for spelling and reading in 60.3 and 28.9% of the families, respectively, indicating a low cost efficiency of the double proband sib pair approach. A recurrence risk of 4.52 (CI: 4.07-4.93) was obtained for spelling when the 1SD criterion was applied to both siblings. Recurrence risk estimates were similar for reading.
  
  
  CONCLUSIONS
  The study demonstrates the suitability of the SPSP design for genetic analysis of dyslexia. The recurrence risk estimates may be used for determining sample sizes in gene mapping studies.
authors.affiliation: Institut fur Medizinische Biometrie und Statistik, Universitatsklinikum Schleswig-Holstein, Campus Lubeck, Universitat zu Lubeck, Lubeck, Germany. ziegler@imbs.uni-luebeck.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Ziegler
authors.forename: Inke R
authors.initials: IR
authors.lastname: König
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Deimel
authors.forename: Ellen
authors.initials: E
authors.lastname: Plume
authors.forename: Markus M
authors.initials: MM
authors.lastname: Nöthen
authors.forename: Peter
authors.initials: P
authors.lastname: Propping
authors.forename: André
authors.initials: A
authors.lastname: Kleensang
authors.forename: Bertram
authors.initials: B
authors.lastname: Müller-Myhsok
authors.forename: Andreas
authors.initials: A
authors.lastname: Warnke
authors.forename: Helmut
authors.initials: H
authors.lastname: Remschmidt
authors.forename: Gerd
authors.initials: G
authors.lastname: Schulte-Körne
mesh_terms: D002648:Child; D004410:Dyslexia / Q000235:genetics*; D005190:Family; D005821:Genetic Techniques; D005858:Germany; D006801:Humans; D007803:Language Arts; D016017:Odds Ratio; D010641:Phenotype; D011932:Reading; D012008:Recurrence; D012306:Risk; D035781:Siblings