How to induce remission in primary systemic vasculitis.
Systemic vasculitis is treatable but not curable. Combination therapy with corticosteroids and immune suppressives induces remission in approximately 90% of cases, and therapeutic regimens have been standardised by randomised controlled trials. Patient subgrouping at presentation reflects prognosis and influences the design of induction regimens. Ongoing problems are therapeutic toxicity, especially in the elderly, the quality of remission obtained and the need for long-term therapy to prevent relapse. Cyclophosphamide remains the most effective immune suppressive, and more recent protocols have minimised its toxicity. An increasing range of newer immune suppressives, and therapeutic recombinant proteins aimed at cytokine blockade or lymphocyte depletion, is emerging. Their correct evaluation and integration with current regimens to improve long-term outcome is the major challenge in clinical vasculitis research today.
Jayne
David
D
Nephrology and Vasculitis, Box 118, Renal Unit, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK. dj106@cam.ac.uk
D019268:Antibodies, Antineutrophil Cytoplasmic; D002986:Clinical Trials as Topic; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016896:Treatment Outcome; D014657:Vasculitis / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy*
D019268:Antibodies, Antineutrophil Cytoplasmic; D005938:Glucocorticoids; D007166:Immunosuppressive Agents