title: Effect of myomectomy on the outcome of assisted reproductive technologies.
abstract: OBJECTIVE
  To evaluate the impact of myomectomy on in vitro fertilization-embryo transfer (IVF-ET) and oocyte donation cycle outcome.
  
  
  METHODS
  Retrospective case-controlled study of consecutive fresh IVF-ET and oocyte donation patients during a 2-year interval.
  
  
  METHODS
  Private assisted reproductive technology (ART) center.
  
  
  METHODS
  Patients with submucosal leiomyomata resected hysteroscopically (group A: 15 oocyte donor recipients; group 1 = 31 IVF-ET patients) and those with intramural components or strictly intramural leiomyomata that distorted or impinged upon the endometrial cavity resected at laparotomy (group B = 26 oocyte donor recipients; group 2 = 29 IVF-ET patients).
  
  
  METHODS
  Precycle hysteroscopic or abdominal myomectomy and subsequent fresh IVF-ET or oocyte donation.
  
  
  METHODS
  Results of controlled ovarian hyperstimulation as well as ongoing pregnancy and implantation rates were evaluated in comparison with contemporaneous patient groups without such lesions (group C = 552 oocyte donor recipients; group 3: 896 IVF-ET patients).
  
  
  RESULTS
  As would be expected, the mean number and size of leiomyomata were significantly larger in patients who underwent abdominal myomectomy. However, neither ongoing pregnancy nor implantation rates were significantly different in comparison with controls among either oocyte donor recipients (group A: 86.7%, 57.8%; group B: 84.6%, 55.2%; group C 77%, 49.1%). The findings were similar for those undergoing IVF-ET in comparison with controls (group 1: 61%, 24%; group 2: 52%, 26%; group 3: 53%, 23%).
  
  
  CONCLUSIONS
  Precycle resection of appropriately selected clinically significant leiomyomata results in IVF-ET or oocyte donation cycle outcomes that are similar to controls.
authors.affiliation: Colorado Center for Reproductive Medicine, Englewood, Colorado 80113, USA. esurrey@colocrm.com
authors.forename: Eric S
authors.initials: ES
authors.lastname: Surrey
authors.forename: Debra A
authors.initials: DA
authors.lastname: Minjarez
authors.forename: John M
authors.initials: JM
authors.lastname: Stevens
authors.forename: William B
authors.initials: WB
authors.lastname: Schoolcraft
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects / Q000379:methods / Q000706:statistics & numerical data; D007889:Leiomyoma / Q000453:epidemiology / Q000601:surgery*; D018587:Oocyte Donation / Q000379:methods / Q000706:statistics & numerical data; D011247:Pregnancy; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000453:epidemiology / Q000601:surgery*