Can chronic subthalamic nucleus stimulation induce de novo tremor in Parkinson's disease?
Subthalamic nucleus stimulation dramatically improves parkinsonian symptoms, notably the tremor. The occurrence of a tremor in the first 6 months after the surgical procedure in patients without tremor preoperatively is much less common. We report on the cases of 3 patients who developed such modification of their parkinsonian symptomatology. Physiopathological hypotheses are discussed.
Thobois
Stephane
S
Sobell Department of Motor Neurosciences and Movement Disorders, Unit of Functional Neurosurgery, Institute of Neurology, London, United Kingdom. s.thobois@ion.ucl.ac.uk
Tisch
Stephen
S
Xie-Brustolin
Jing
J
Mertens
Patrick
P
Hariz
Marwan I
MI
Benatru
Isabelle
I
Broussolle
Emmanuel
E
Limousin-Dowsey
Patricia
P
D000368:Aged; D046690:Deep Brain Stimulation / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000601:surgery*; D020531:Subthalamic Nucleus / Q000503:physiopathology / Q000528:radiation effects*; D014202:Tremor / Q000209:etiology*