title: [Effect of hyperhomocysteinemia and methylenetetrahydrofolate reductase 677C --> T mutation in venous thromboembolism risk of young adults].
abstract: OBJECTIVE
  To investigate whether hyperhomocysteinemia and methylenetetrahydrofolate reductase (MTHFR) 677C --> T mutation are associated with venous thromboembolism in young Spanish adults.
  
  
  METHODS
  One hundred adult patients younger than 50 years and 177 controls with similar age and gender.
  
  
  RESULTS
  Hyperhomocysteinemia was present in 21% of the patients and 3.3% of the controls (p < 0.001), and MTHFR 677C --> T mutation was found in 25 and 14.7%, respectively (p = 0.03). Odds ratio (OR) for thromboembolism in hyperhomocysteinemic patients was 7.5 (95% CI, 2.9-19.2; p < 0.001), and in patients with MTHFR 677C --> T mutation the OR was 1.9 (95% CI, 1.1-3.5; p = 0.03). In a subgroup of 76 patients without other thrombogenic factors, thromboembolism persisted associated with hyperhomocysteinemia, yet an association with MTHFR 677C --> T mutation was not confirmed.
  
  
  CONCLUSIONS
  Hyperhomocysteinemia, but not MTHFR 677C --> T mutation, is a risk factor for venous thromboembolism in young adults without other thrombogenic factors.
authors.affiliation: Servicio de Medicina Interna, Hospital Universitario 12 de Octubre, Madrid, Spain. cfmiranda@inicia.es
authors.forename: Consuelo
authors.initials: C
authors.lastname: Fernández-Miranda
authors.forename: Angel
authors.initials: A
authors.lastname: Coto
authors.forename: Joaquín
authors.initials: J
authors.lastname: Martínez
authors.forename: Pilar
authors.initials: P
authors.lastname: Gómez
authors.forename: Agustín
authors.initials: A
authors.lastname: Gómez de la Cámara
mesh_terms: D000328:Adult; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications*; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D009154:Mutation; D012307:Risk Factors; D013923:Thromboembolism / Q000453:epidemiology* / Q000209:etiology
chemical_list: D006710:Homocysteine; D042965:Methylenetetrahydrofolate Reductase (NADPH2)