Effects of olanzapine on auditory P300 and mismatch negativity (MMN) in schizophrenia spectrum disorders.
We investigated effects of olanzapine (5-10 mg/day) on passive and active attention in 11 patients with schizophrenia spectrum disorders and 15 healthy controls by using auditory evoked potentials (AEPs) mismatch negativity (MMN) and P300. AEPs were elicited during active and passive auditory "oddball" paradigms before, after 2 weeks and 4 weeks of olanzapine treatment. Baseline P300 amplitudes, but not MMN, were significantly reduced in patients compared with controls. Although clinical signs improved significantly measured by Positive and Negative Syndrome Scale (PANSS), olanzapine had no significant effects on latencies and amplitudes of MMN and P300. Thus, olanzapine does not have effects on active and passive attention in patients with schizophrenia spectrum disorders. Four weeks olanzapine treatment may be insufficient for the improvement of cognitive dysfunction in terms of inability to focus on relevant stimuli in these patients.
Korostenskaja
Milena
M
Department of Electrophysiology, Republican Vilnius Psychiatric Hospital, Parko-15, Vilnius, LT-2041, Lithuania. milena@rvpl.lt
Dapsys
Kastysis
K
Siurkute
Aldona
A
Maciulis
Valentinas
V
Ruksenas
Osvaldas
O
Kähkönen
Seppo
S
D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001288:Attention / Q000187:drug effects*; D001569:Benzodiazepines / Q000494:pharmacology* / Q000627:therapeutic use; D018913:Event-Related Potentials, P300 / Q000187:drug effects*; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology*; D012565:Schizophrenic Psychology
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine