title: Experimental study and nuclear model calculations on the 192Os(p,n)192Ir reaction: Comparison of reactor and cyclotron production of the therapeutic radionuclide 192Ir.
abstract: In a search for an alternative route of production of the important therapeutic radionuclide (192)Ir (T(1/2)=78.83 d), the excitation function of the reaction (192)Os(p,n)(192)Ir was investigated from its threshold up to 20 MeV. Thin samples of enriched (192)Os were obtained by electrodeposition on Ni, and the conventional stacked-foil technique was used for cross section measurements. The experimental data were compared with the results of theoretical calculations using the codes EMPIRE-II and ALICE-IPPE. Good agreement was found with EMPIRE-II, but slightly less with the ALICE-IPPE calculations. The theoretical thick target yield of (192)Ir over the energy range E(p)=16-->8 MeV amounts to only 0.16MBq/muA.h. A comparison of the reactor and cyclotron production methods is given. In terms of yield and radionuclidic purity of (192)Ir the reactor method appears to be superior; the only advantage of the cyclotron method could be the higher specific activity of the product.
authors.affiliation: Institut für Nuklearchemie, Forschungszentrum Jülich GmbH, D-52425 Jülich, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Hilgers
authors.forename: S
authors.initials: S
authors.lastname: Sudár
authors.forename: S M
authors.initials: SM
authors.lastname: Qaim
mesh_terms: D017357:Cyclotrons; D007496:Iridium Radioisotopes / Q000737:chemistry*; D008956:Models, Chemical; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D007496:Iridium Radioisotopes; D019275:Radiopharmaceuticals