Comparison of fine needle aspiration cytology with excision biopsy of breast lump.
OBJECTIVE
To evaluate the results of fine needle aspiration cytology (FNAC) of breast lump by histopathology of excision biopsy specimen in the same group of patients.


METHODS
A descriptive study.


METHODS
Department of Surgery, Federal Government Services Hospital, Islamabad from October, 2000 to March, 2001.


METHODS
There were 50 patients in the study, who were subjected to fine needle aspiration cytology with a needle of 22G mounted on 20 cc syringe. Smears were fixed on the slides with 95% alcohol and later stained with hematoxylin and eosin stain. After FNAC, all the patients were subjected to excision biopsy. The specimen were reported by the Histopathologist and results evaluated and compared.


RESULTS
All patients were among the total number of 61 FNAC performed, conclusive malignancy (C5) was found in 20(40%) patients and in 1(2%) patient, malignancy was suspected (C4). Conclusive benign lesions (C2) were found in 26(52%) patients and 2 patients had atypia i.e. (C3). Inadequate specimen (C1) was found in 2(4%) patients. On excision biopsy, 22(44%) patients had malignant lumps and 28(56%) benign. FNAC was able to detect 20 malignant lumps with sensitivity of 90.90%. All of them were also reported malignant on excision biopsy with specificity of 100%. False positive were zero and false negative were 9.1%.


CONCLUSIONS
FNAC is simple, quick, safe, tolerable, cosmetically acceptable, reliable and cost-effective method of determining histology of breast lumps. The absence of false positives conclusively confirmed its place not only as a complimentary adjunct but also a substitute of excision biopsy in majority of instances.
Hussain
Mirza Tassawar
MT
Department of Surgery, Federal Government Services Hospital, Islamabad. drnido@hotmail.com
D000293:Adolescent; D000328:Adult; D000368:Aged; D001365:Axilla; D044963:Biopsy, Fine-Needle; D001943:Breast Neoplasms / Q000473:pathology* / Q000556:secondary; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D021701:Sentinel Lymph Node Biopsy