title: Effect of adiposity and fat distribution on endometrial cancer risk in Shanghai women.
abstract: The authors conducted a population-based case-control study of 832 endometrial cancer cases and 846 frequency-matched controls in Shanghai, China (1997-2001), to examine the association of overall adiposity and body fat distribution with disease risk. Overall adiposity was estimated using weight and body mass index (BMI); upper body fat distribution was evaluated using waist circumference and waist:hip ratio. Overall and upper-body obesity were both associated with an elevated risk of endometrial cancer. Adjusted odds ratios and 95% confidence intervals for highest-versus-lowest quartile comparisons were 2.6 (95% confidence interval (CI): 2.0, 3.5) for weight, 2.9 (95% CI: 2.2, 3.9) for BMI, 4.7 (95% CI: 3.4, 6.4) for waist circumference, and 3.5 (95% CI: 2.6, 4.8) for waist:hip ratio. The positive associations with weight and BMI vanished after results were controlled for waist circumference, while associations with waist circumference and waist:hip ratio persisted after adjustment for BMI. The positive association with upper-body obesity was more pronounced among younger women, women who had never used oral contraceptives, and women with a history of diabetes mellitus (p for multiplicative interaction < 0.05). Upper-body obesity was related to increased risk among women with low BMI. These results suggest that obesity, particularly upper-body fat deposition, is associated with an increased risk of endometrial cancer.
authors.affiliation: Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China.
authors.forename: Wang Hong
authors.initials: WH
authors.lastname: Xu
authors.forename: Charles E
authors.initials: CE
authors.lastname: Matthews
authors.forename: Yong Bing
authors.initials: YB
authors.lastname: Xiang
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.forename: Zhi Xian
authors.initials: ZX
authors.lastname: Ruan
authors.forename: Jia Rong
authors.initials: JR
authors.lastname: Cheng
authors.forename: Yu Tang
authors.initials: YT
authors.lastname: Gao
authors.forename: Xiao Ou
authors.initials: XO
authors.lastname: Shu
mesh_terms: D000273:Adipose Tissue / Q000503:physiopathology*; D000328:Adult; D017677:Age Distribution; D000368:Aged; D001823:Body Composition; D049628:Body Size; D016022:Case-Control Studies; D015984:Causality; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D003276:Contraceptives, Oral; D016889:Endometrial Neoplasms / Q000453:epidemiology* / Q000503:physiopathology*; D005260:Female; D015438:Health Behavior; D006801:Humans; D008019:Life Style; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology* / Q000503:physiopathology*; D016017:Odds Ratio; D012307:Risk Factors; D012959:Socioeconomic Factors
chemical_list: D003276:Contraceptives, Oral