title: Responses of chickens vaccinated with a live attenuated multi-valent ionophore-tolerant Eimeria vaccine.
abstract: Coccidiosis, caused by Eimeria species, is a serious economic disease of chickens (Gallus gallus) and the search for vaccines to control the disease is intensifying especially with the increasing threat of drug resistance. A live attenuated multi-valent ionophore-tolerant Eimeria vaccine has been developed that contains three ionophore-resistant Eimeria species, E. tenella, E. maxima and E. acervulina. The attenuated lines were derived from virulent field strains resistant to monensin ionophore by selection for early development in chicks. The vaccine was administered by gavage and through drinking water to broiler chickens, Chinese Yellow strain, reared in wire cages. Vaccinated medicated birds performed better than vaccinated unmedicated and medicated unvaccinated groups. The final mean weights of vaccinated medicated birds were significantly higher (P<0.05), and a better vaccine protection index, using both vaccinating methods, was achieved. Results indicated that concomitant use of ionophores and vaccines could be a useful adjunct to planned immunization in the control of coccidiosis.
authors.affiliation: Department of Veterinary Parasitology, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, PR China. gqli@scau.edu.cn
authors.forename: G Q
authors.initials: GQ
authors.lastname: Li
authors.forename: S
authors.initials: S
authors.lastname: Kanu
authors.forename: S M
authors.initials: SM
authors.lastname: Xiao
authors.forename: F Y
authors.initials: FY
authors.lastname: Xiang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000276:immunology; D002645:Chickens / Q000276:immunology*; D003048:Coccidiosis / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control / Q000662:veterinary*; D004539:Eimeria / Q000276:immunology*; D005243:Feces / Q000469:parasitology; D005260:Female; D007476:Ionophores / Q000494:pharmacology; D008297:Male; D008985:Monensin / Q000494:pharmacology; D010270:Parasite Egg Count / Q000662:veterinary; D011201:Poultry Diseases / Q000276:immunology / Q000469:parasitology* / Q000517:prevention & control; D016052:Protozoan Vaccines / Q000276:immunology*; D014611:Vaccination / Q000379:methods / Q000662:veterinary*; D014613:Vaccines, Attenuated / Q000276:immunology
chemical_list: D007476:Ionophores; D016052:Protozoan Vaccines; D014613:Vaccines, Attenuated; D008985:Monensin