Tumor necrosis factor alpha plays a role in the acceleration of atherosclerosis by Chlamydia pneumoniae in mice.
The role of tumor necrosis factor alpha (TNF-alpha) in Chlamydia pneumoniae atherogenesis was evaluated in TNF-alpha p55 receptor-deficient C57BL/6J mice fed a high-fat/high-cholesterol diet. No acceleration of atherosclerotic lesion development was observed in infected mice compared to uninfected mice, indicating that TNF-alpha plays a role in the acceleration of atherosclerosis by C. pneumoniae.
Campbell
Lee Ann
LA
Department of Pathobiology, Box 357238, University of Washington, Seattle, WA 98195, USA.
Nosaka
Tadayoshi
T
Rosenfeld
Michael E
ME
Yaraei
Kambiz
K
Kuo
Cho-Chou
CC
D000818:Animals; D001161:Arteriosclerosis / Q000382:microbiology* / Q000503:physiopathology*; D023521:Chlamydophila Infections / Q000382:microbiology / Q000503:physiopathology; D016993:Chlamydophila pneumoniae / Q000378:metabolism / Q000472:pathogenicity*; D006949:Hyperlipidemias / Q000382:microbiology* / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics; D047888:Receptors, Tumor Necrosis Factor, Type I; D053319:Tumor Necrosis Factor Decoy Receptors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D018124:Receptors, Tumor Necrosis Factor; D047888:Receptors, Tumor Necrosis Factor, Type I; D053319:Tumor Necrosis Factor Decoy Receptors; D014409:Tumor Necrosis Factor-alpha; C069521:recombinant human tumor necrosis factor-binding protein-1