title: Pediatric meningosarcoma: clinical evolution and genetic instability.
abstract: This report presents a female diagnosed with a frontoparietal interhemispheric meningosarcoma who, parallel to the clinical worsening, revealed an increase in the genetic instability (in bleomycin cultures) and the complexity of the karyotypes, with the acquisition of a clonal deletion of 17p13 (the locus for the TP53 tumor suppressor gene). The genetic findings of this patient suggest that the increased genetic instability could contribute to tumor progression as well as to treatment resistance, possibly in the background of the clonal deletion of TP53.
authors.affiliation: Laboratory and Department of Pediatrics, University Clinic and University of Navarra, Pamplona, Spain.
authors.forename: Reyes López
authors.initials: RL
authors.lastname: de Mesa
authors.forename: Luis
authors.initials: L
authors.lastname: Sierrasesúmaga
authors.forename: Adela López
authors.initials: AL
authors.lastname: de Cerain
authors.forename: María José
authors.initials: MJ
authors.lastname: Calasanz
authors.forename: Ana
authors.initials: A
authors.lastname: Patiño-García
mesh_terms: D002648:Child; D018450:Disease Progression; D005260:Female; D017353:Gene Deletion; D006801:Humans; D007621:Karyotyping; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000235:genetics* / Q000473:pathology*; D008579:Meningioma / Q000235:genetics* / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D016159:Tumor Suppressor Protein p53