CD1 and MHC II find different means to the same end.
CD1 molecules are a third family of antigen-presenting molecules and are the only one specialized to present lipid-containing antigens. Some CD1 molecules traffic to the same intracellular compartments as MHC II molecules. Moreover, MHC II and the class II-associated invariant chain influence CD1d trafficking. Despite this intersection between the MHC II and CD1 pathways, CD1 proteins use a mechanism entirely different from MHC II to traffic to late endosomes to acquire antigens. Recent experimental evidence has illuminated these unique aspects of the CD1 antigen-presentation pathway.
Sullivan
Barbara A
BA
La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA.
Nagarajan
Niranjana A
NA
Kronenberg
Mitchell
M
D033942:Adaptor Proteins, Vesicular Transport / Q000378:metabolism; D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D018949:Antigens, CD1 / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D002241:Carbohydrates / Q000737:chemistry / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D021381:Protein Transport
D033942:Adaptor Proteins, Vesicular Transport; D018949:Antigens, CD1; D002241:Carbohydrates; D000949:Histocompatibility Antigens Class II