title: Reversible insulin self-assembly under carbohydrate control.
abstract: Insulin with built-in pairs of boronates and polyols can produce soluble high molecular weight self-assemblies under control by carbohydrates. The illustrated principle has potential utility for general protein and peptide protraction and controlled drug release.
authors.affiliation: Novo Nordisk, Novo Alle 6B2.54, DK-2880 Bagsvaerd, Denmark. tshj@novonordisk.com
authors.forename: Thomas
authors.initials: T
authors.lastname: Hoeg-Jensen
authors.forename: Svend
authors.initials: S
authors.lastname: Havelund
authors.forename: Peter K
authors.initials: PK
authors.lastname: Nielsen
authors.forename: Jan
authors.initials: J
authors.lastname: Markussen
mesh_terms: D000595:Amino Acid Sequence; D001897:Boronic Acids / Q000737:chemistry; D002850:Chromatography, Gel; D005947:Glucose / Q000737:chemistry*; D007328:Insulin / Q000737:chemistry*; D007700:Kinetics; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011972:Receptor, Insulin / Q000737:chemistry; D013012:Sorbitol / Q000737:chemistry*
chemical_list: D001897:Boronic Acids; D007328:Insulin; D013012:Sorbitol; D011972:Receptor, Insulin; D005947:Glucose