Comparison of diets high in monounsaturated versus polyunsaturated fatty acid on postprandial lipoproteins in diabetes.
BACKGROUND
Postprandial hypertriglyceridaemia is common in diabetes. Fatty acids are regulators of gene expression and may play an important role in regulatingthe postprandial lipoprotein cascade.


OBJECTIVE
To examine postprandial lipoprotein differences between diabetic and control subjects on polyunsaturated (linoleic) and monounsaturated (oleic) fat diets.


METHODS
A randomised, crossover study.


RESULTS
LDL was greater and HDL less (p < 0.05) in diabetic patients compared to controls on the linoleic acid diet. Apo E per particle was significantly lower in the diabetic patients compared to control subjects on both linoleic (p < 0.05) and oleic acid diets (p < 0.01). HDL apo E was also significantly lower in the diabetic patients compared to controls on the linoleic acid diet (p < 0.02).


CONCLUSIONS
A change from linoleic to oleic acid diet resulted in an improvement in LDL and HDL in the diabetic patients. We suggest that the reduced apo E/particle in the diabetic patients may be an explanation for the delayed lipoprotein clearance.
Madigan
C
C
Department of Clinical Medicine, Trinity College, Dublin.
Ryan
M
M
Owens
D
D
Collins
P
P
Tomkin
G H
GH
D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D018592:Cross-Over Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000178:diet therapy*; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood; D019787:Linoleic Acid / Q000008:administration & dosage / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D019301:Oleic Acid / Q000008:administration & dosage / Q000378:metabolism*; D019518:Postprandial Period
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D019301:Oleic Acid; D019787:Linoleic Acid