title: Facile and convenient syntheses of 6,11-dihydro-5H-indeno[1,2-c]isoquinolin- 5-ones and 6,11-dihydro-5H-indolo[3,2-c]isoquinolin-5-one.
abstract: [reaction: see text] The synthesis of 6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-ones from the base-promoted condensation reaction of homophthalic anhydride and 2-(bromomethyl)-benzonitrile and a convenient method for the synthesis of indolo[3,2-c]isoquinolinones are described.
authors.affiliation: Inotek Pharmaceuticals Corporation, 100 Cummings Center, Beverly, Massachusetts 01915, USA. pjagtap@inotekcorp.com
authors.forename: Prakash G
authors.initials: PG
authors.lastname: Jagtap
authors.forename: Erkan
authors.initials: E
authors.lastname: Baloglu
authors.forename: Garry
authors.initials: G
authors.lastname: Southan
authors.forename: William
authors.initials: W
authors.lastname: Williams
authors.forename: Aloka
authors.initials: A
authors.lastname: Roy
authors.forename: Alexander
authors.initials: A
authors.lastname: Nivorozhkin
authors.forename: Nelson
authors.initials: N
authors.lastname: Landrau
authors.forename: Kevin
authors.initials: K
authors.lastname: Desisto
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Salzman
authors.forename: Csaba
authors.initials: C
authors.lastname: Szabó
mesh_terms: D020650:Combinatorial Chemistry Techniques; D007192:Indenes / Q000138:chemical synthesis*; D007211:Indoles / Q000138:chemical synthesis*; D007546:Isoquinolines / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D007192:Indenes; D007211:Indoles; D007546:Isoquinolines