title: Synthesis and antifungal activity of 5-arylamino-4,7-dioxobenzo[b]thiophenes.
abstract: 5-Arylamino-4,7-dioxobenzo[b]thiophenes 3-6 were synthesized and tested for in vitro antifungal activity against Candida and Aspergillus species. 5-Arylamino-6-chloro-2-(methoxycarbonyl)-4,7-dioxobenzo[b]thiophenes 5 showed, in general, more potent antifungal activity against Candida species than the other 4,7-dioxobenzo[b]thiophenes 3, 4 and 6. The results suggest that 5-arylamino-4,7-dioxobenzo[b]thiophenes would be potent antifungal agents.
authors.affiliation: College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, South Korea. ckryu@mm.ewha.ac.kr
authors.forename: Chung-Kyu
authors.initials: CK
authors.lastname: Ryu
authors.forename: Su-Kyung
authors.initials: SK
authors.lastname: Lee
authors.forename: Ja-Young
authors.initials: JY
authors.lastname: Han
authors.forename: Ok-Jai
authors.initials: OJ
authors.lastname: Jung
authors.forename: Jung Yoon
authors.initials: JY
authors.lastname: Lee
authors.forename: Seong Hee
authors.initials: SH
authors.lastname: Jeong
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D013876:Thiophenes