Fibroblast growth factor signaling in tumorigenesis.
Fibroblast growth factors and their signaling receptors have been associated with multiple biological activities, including proliferation, differentiation and motility. Consequently, they have evoked interest as candidate oncogenes with the potential to initiate and/or promote tumorigenesis. This has resulted in a large literature describing the presence of these growth factors and their receptors in cancer cell lines and primary tumors of diverse origin. However, it is only recently that compelling evidence has emerged to implicate the fibroblast growth factors (Fgfs) and their receptors in the genesis of human cancers. Here, we outline the model systems that demonstrate the potential oncogenic nature of Fgf signaling and summarise recent evidence that implicates aberrant Fgf signaling as important in the natural history of some common human cancers.
Grose
Richard
R
Cancer Research UK London Research Institute, Viral Carcinogenesis, Laboratory 214, 61 Lincoln's Inn Fields, London WC2A 3PX, UK. richard.grose@cancer.org.uk
Dickson
Clive
C
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005346:Fibroblast Growth Factors / Q000502:physiology*; D019337:Hematologic Neoplasms / Q000209:etiology; D006801:Humans; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000209:etiology; D009369:Neoplasms / Q000209:etiology*; D011471:Prostatic Neoplasms / Q000209:etiology; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology; D017468:Receptors, Fibroblast Growth Factor / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D012878:Skin Neoplasms / Q000209:etiology; D014571:Urologic Neoplasms / Q000209:etiology
D017468:Receptors, Fibroblast Growth Factor; D005346:Fibroblast Growth Factors; D020794:Receptor Protein-Tyrosine Kinases