Serum selenoprotein-P levels in patients with inflammatory bowel disease.
OBJECTIVE
Selenoprotein-P is a selenium-rich serum protein that carries more than 50% of serum selenium. We evaluated changes in serum selenoprotein-P levels in patients with inflammatory bowel disease.


METHODS
Serum selenoprotein-P levels were measured by enzyme-linked immunosorbent assay. Twenty healthy individuals (controls), 34 patients with ulcerative colitis, and 37 patients with Crohn's disease (CD) were studied.


RESULTS
A highly significant correlation was found between the serum selenium and selenoprotein-P levels. There was no significant difference in serum selenoprotein-P levels between healthy controls (average 3.4+/-0.8 microg/mL, n=20) and patients with ulcerative colitis (3.0+/-1.0 microg/mL, n=34). Serum selenoprotein-P levels were significantly lower in patients with CD (average 1.8+/-0.5 microg/mL, n=37). Serum selenoprotein-P levels were significantly lower in the elemental diet group of patients who had CD (average 1.4+/-0.4 microg/mL, n=17) than in the non-elemental diet group of patients who had CD (average 2.1+/-0.3 microg/mL, n=20).


CONCLUSIONS
We found that the serum selenoprotein-P level is decreased in patients with CD. It may be a useful marker to monitor the systemic selenium status in various disorders.
Andoh
Akira
A
Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan. andoh@belle.shiga-med.ac.jp
Hirashima
Masaki
M
Maeda
Hiroaki
H
Hata
Kazunori
K
Inatomi
Osamu
O
Tsujikawa
Tomoyuki
T
Sasaki
Masaya
M
Takahashi
Kazuhiko
K
Fujiyama
Yoshihide
Y
D000328:Adult; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000097:blood; D003424:Crohn Disease / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000097:blood*; D008297:Male; D009752:Nutritional Status; D011506:Proteins / Q000378:metabolism*; D012643:Selenium / Q000097:blood*; D051149:Selenoprotein P; D051140:Selenoproteins; D013054:Spectrophotometry, Atomic / Q000379:methods
D011506:Proteins; D051149:Selenoprotein P; D051140:Selenoproteins; D012643:Selenium