title: A facile route to paclitaxel C-10 carbamates.
abstract: A general protocol for the synthesis of paclitaxel C-10 carbamates is described. The method entails MeI-mediated activation of 2'-O-TBS-7-O-TES-10-O-deacetyl-paclitaxel-10-O-carbonylimidazole prior to reaction with amines. This method is effective for the synthesis of paclitaxel C-10 derivatives, including bifunctional molecules.
authors.affiliation: Acidophil, LLC, Suite 250, 10835 Road to the Cure, San Diego, CA 92121, USA.
authors.forename: Carlo
authors.initials: C
authors.lastname: Ballatore
authors.forename: Simon E
authors.initials: SE
authors.lastname: Aspland
authors.forename: Rosario
authors.initials: R
authors.lastname: Castillo
authors.forename: Joel
authors.initials: J
authors.lastname: Desharnais
authors.forename: Trisha
authors.initials: T
authors.lastname: Eustaquio
authors.forename: Chengzao
authors.initials: C
authors.lastname: Sun
authors.forename: Angelo J
authors.initials: AJ
authors.lastname: Castellino
authors.forename: Amos B
authors.initials: AB
authors.lastname: Smith
mesh_terms: D002219:Carbamates / Q000737:chemistry*; D017239:Paclitaxel / Q000138:chemical synthesis*
chemical_list: D002219:Carbamates; D017239:Paclitaxel