Prevalence and characterization of invasive isolates of Streptococcus pyogenes with reduced susceptibility to fluoroquinolones.
Fluoroquinolone susceptibility testing was performed on invasive group A streptococcus isolates from 1992-1993 and 2003 from Ontario, Canada. None were nonsusceptible to levofloxacin. Two of 153 (1.3%) from 1992-1993 and 7 of 160 (4.4%) from 2003 had a levofloxacin MIC of 2 mug/ml; all nine had parC mutations, and eight were serotype M6.
Powis
Jeff
J
Department of Microbiology, Toronto Medical Laboratories, Mount Sinai Hospital, 600 University Ave., Toronto, Ontario, Canada M5G 1X5.
McGeer
Allison
A
Duncan
Carla
C
Goren
Ryan
R
de Azavedo
Joyce C S
JC
Bast
Darrin J
DJ
Pong-Porter
Sylvia
S
Mazzulli
Tony
T
Green
Karen
K
Willey
Barbara
B
Low
Donald E
DE
D000890:Anti-Infective Agents / Q000494:pharmacology*; D027101:DNA Topoisomerase IV / Q000235:genetics; D024881:Drug Resistance, Bacterial; D024841:Fluoroquinolones / Q000494:pharmacology*; D006801:Humans; D009864:Ontario / Q000453:epidemiology; D011159:Population Surveillance; D013290:Streptococcal Infections / Q000453:epidemiology* / Q000382:microbiology*; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000235:genetics*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D027101:DNA Topoisomerase IV