title: Comparison of type-specific human papillomavirus data from self and clinician directed sampling.
abstract: OBJECTIVE
  To compare the type-specific human papillomavirus (HPV) recovery from physician and patient-collected samples.
  
  
  METHODS
  Three hundred thirty-four (334) women attending colposcopy clinics in three countries were enrolled in this cross-sectional study. Cervicovaginal samples were collected by patients and physicians and processed with polymerase chain reaction and reverse line blot genotyping. McNemar's Chi-squared tests and Kappa statistics were utilized to determine statistical associations between physician- versus patient-collected samples.
  
  
  RESULTS
  Oncogenic HPV infection was identified in 23.2% of patient-collected specimens compared to 34.9% of physician-collected specimens. Physician sampling detected significantly more infections with type 16 and 52 than did self-sampling and significantly more oncogenic HPV infection overall. For non-oncogenic HPV detection, there was no statistical difference between physician- and patient-collected samples.
  
  
  CONCLUSIONS
  Patient sampling for HPV using a single vaginal brush does not identify all oncogenic HPV subtypes.
authors.affiliation: The Department of Obstetrics and Gynecology, University of Arizona Health Sciences Center, 1501 N. Campbell Avenue, Tucson, AZ 85724, USA.
authors.forename: Susie
authors.initials: S
authors.lastname: Baldwin
authors.forename: Carlos
authors.initials: C
authors.lastname: Santos
authors.forename: Elena
authors.initials: E
authors.lastname: Mendez Brown
authors.forename: Thomas
authors.initials: T
authors.lastname: Nuño
authors.forename: Anna
authors.initials: A
authors.lastname: Giuliano
authors.forename: John
authors.initials: J
authors.lastname: Davis
authors.forename: Francisco
authors.initials: F
authors.lastname: Garcia
mesh_terms: D003127:Colposcopy; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000145:classification* / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000821:virology*; D012648:Self Care; D002577:Uterine Cervical Diseases / Q000821:virology*