The use of biochemical markers in prenatal diagnosis of intrauterine growth retardation: insulin-like growth factor I, Leptin, and alpha-fetoprotein.
OBJECTIVE
To determine the relation between weight deficit at birth and IGF-I, IGFBP-I, Leptin, and AFP levels in amniotic fluid after 14-18 weeks; to assess the diagnostic usefulness of these biochemical markers.


METHODS
Longitudinal, prospective study. Amniocentesis was performed in pregnant women after 14-18 weeks of gestation.


METHODS
86 controls, 18 IUGR <10 percentile, and 17 IUGR <5 percentile.


RESULTS
No significant correlation was found between severity of IUGR and IGF-I, IGFBP-I, or Leptin. AFP was inversely correlated with severity of IUGR; results for the IUGR <10 percentile were: S: 65.7%, SP: 56.9%, PPV: 38.3%, NPV: 80.3%, and an overall diagnostic capacity of 65.6%. Results for the IUGR <5 percentile were: S: 76.4%, SP: 54.8%, PPV: 21.6%, NPV: 93.4% were obtained, and an overall capacity of 70.6%.


CONCLUSIONS
Elevated values of AFP in amniotic fluid may help early detection of populations at risk of developing IUGR.
Roig
M Dolores Gómez
MD
Obstetrics and Gynecology Service, Sant Joan de Déu University Hospital, Barcelona, Spain. lolagomez@eresmas.com
Sabrià
Joan
J
Valls
Carme
C
Borràs
Miquel
M
Miró
Elisabet
E
Ponce
Jordi
J
Vicens
José M Laïlla
JM
D000649:Amniocentesis; D000653:Amniotic Fluid / Q000737:chemistry; D015415:Biomarkers / Q000032:analysis*; D005317:Fetal Growth Retardation / Q000175:diagnosis*; D005865:Gestational Age; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000032:analysis; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D020738:Leptin / Q000032:analysis*; D008137:Longitudinal Studies; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D000509:alpha-Fetoproteins / Q000032:analysis*
D015415:Biomarkers; D018970:Insulin-Like Growth Factor Binding Protein 1; D020738:Leptin; D000509:alpha-Fetoproteins; D007334:Insulin-Like Growth Factor I