title: Microvascular density of rapidly destructive arthropathy of the hip joint.
abstract: OBJECTIVE
  To assess the vascularity of the femoral head and determine how it is related to the destruction of the arthritic hip joint. The process of destructive arthropathy in arthritic hip joints is variable. Some patients with osteoarthritis of the hip have rapidly progressive destructive changes resulting in the disappearance of the femoral head.
  
  
  METHODS
  Six femoral heads from patients diagnosed with rapidly destructive arthropathy and 6 femoral heads from patients with secondary osteoarthritis caused by acetabular dysplasia were analysed to reveal the association between blood capillaries and osteoclasts. The von Willebrand Factor immunostaining and counterstaining with Mayer's haematoxylin were used to label the microvessels and osteoclasts in formalin-fixed, paraffin-embedded specimens of femoral heads. The numbers of immunostained microvessels and osteoclasts in selected regions were counted.
  
  
  RESULTS
  The microvascular density of the bone surfaces of rapidly progressive arthritic hips was hypervascular. Osteoclasts were also found in increased numbers on the bone surfaces of rapidly progressive arthritic hips. The higher microvascular density coincided with extensive bone destruction and with the increased osteoclast count.
  
  
  CONCLUSIONS
  These findings suggested that hypervascularity of the granulation in the femoral head may be associated with bone and joint destruction.
authors.affiliation: Department of Orthopedic Surgery, Mie University Faculty of Medicine, Mie University Hospital, Tsu, Mie, Japan. yammakawa@hotmail.com
authors.forename: T
authors.initials: T
authors.lastname: Yamakawa
authors.forename: A
authors.initials: A
authors.lastname: Sudo
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: A
authors.initials: A
authors.lastname: Uchida
mesh_terms: D000328:Adult; D000368:Aged; D002452:Cell Count; D005270:Femur Head / Q000098:blood supply* / Q000473:pathology; D006801:Humans; D009389:Neovascularization, Pathologic; D015207:Osteoarthritis, Hip / Q000473:pathology*; D010010:Osteoclasts / Q000473:pathology*