title: Real-life environmental tobacco exposure does not affect exhaled nitric oxide levels in asthmatic children.
abstract: Serial measurement of exhaled nitric oxide (eNO) has been shown to be a good noninvasive marker of asthma control. Active smoking decreases eNO levels. The effect of real-life environmental exposure to tobacco smoke (ETS) on eNO levels is not known. Our objective was to study the impact of environmental tobacco exposure on eNO levels in asthmatic and non-asthmatic children. Single breath off-line collection of eNO was performed in asthmatic and non-asthmatic children with and without ETS. Urine was collected for cotinine/nicotine analysis. Fifty-seven children were enrolled, of which 25 were asthmatic and 32 had smoke exposure. One active smoker was excluded from the data analysis. The mean eNO was 11.1 ppb (n = 31; SD = 18.5) in those passively exposed vs. 11.1 ppb (n = 25; SD = 19.9) among the unexposed (not statistically significant). The mean eNO was 6.1 (n = 32; SD = 4.4) among the non-asthmatics and 17.8 (n = 24; SD = 27.4) among the asthmatics (p = 0.02; CI: 1.9-21.6). Real-life environmental tobacco exposure does not appear to decrease eNO levels in asthmatic children. Off-line collection of exhaled nitric oxide with a Mylar collection device helps differentiate asthmatics from non-asthmatics.
authors.affiliation: Section of Allergy/Immunology, Children's Mercy Hospital, Kansas City, Missouri 64108-4968, USA. cdinakar@cmh.edu
authors.forename: Chitra
authors.initials: C
authors.lastname: Dinakar
authors.forename: Michael
authors.initials: M
authors.lastname: Lapuente
authors.forename: Charles
authors.initials: C
authors.lastname: Barnes
authors.forename: Uttam
authors.initials: U
authors.lastname: Garg
mesh_terms: D001249:Asthma / Q000378:metabolism* / Q000652:urine; D002648:Child; D003367:Cotinine / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D009538:Nicotine / Q000652:urine; D009569:Nitric Oxide / Q000378:metabolism*; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
chemical_list: D014028:Tobacco Smoke Pollution; D009569:Nitric Oxide; D009538:Nicotine; D003367:Cotinine