Outcome following single vs bilateral lung transplantation in recipients 60 years of age and older.
OBJECTIVE
The significant shortage of donor organs in lung transplantation necessitates a careful selection of lung transplant recipients. The outcome of lung transplant recipients aged 60 years and older has not been analyzed systematically.


METHODS
We retrospectively reviewed our experience with older recipients. Between January 1999 and July 2003, 248 patients underwent lung transplantation at our institution, of which 18 were aged 60 years and older (7.3%, range 60-66, mean 62 +/- 1.1).


RESULTS
Eleven (61%) of the recipients 60 years and older received a single (SLTx) and seven (39%), a bilateral lung transplant. Donor age in the single transplant cohort was 30 +/- 4 years. It was 33 +/- 3 years in bilateral patients. Posttransplant ventilation time was significantly different among groups, with 282 +/- 32 hours after bilateral and 56 +/- 13 hours after transplant (P < .05). Also significantly longer was the length of the ICU stay in the bilateral group. First PaO2 in the ICU was not different among the two groups. The 1-year survival in the single transplant group was significantly better compared to the bilateral group with 73% versus 43%, respectively.


CONCLUSIONS
The 1-year survival following lung transplantation in patients older than 60 years is markedly reduced compared to recipients under 60 years of age. If a lung transplant is considered in a recipient above the age of 60 years, a single transplant should be favoured. If that is not indicated, patients over 60 should be very carefully selected for bilateral transplant.
Fischer
S
S
Hannover Thoracic Organ Transplant Program, Division of Thoracic and Cardiovascular Surgery Hannover Medical School, Hannover, Germany.
Meyer
K
K
Tessmann
R
R
Meyer
A
A
Gohrbandt
B
B
Simon
A
A
Hagl
C
C
Kallenbach
K
K
Haverich
A
A
Strüber
M
M
D000368:Aged; D007839:Functional Laterality; D006801:Humans; D016040:Lung Transplantation / Q000379:methods* / Q000401:mortality / Q000502:physiology; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome