title: Pharmacological properties of N-095, a drug containing red ginseng, polygala root, saffron, antelope horn and aloe wood.
abstract: This study sought to establish a pharmacological profile for N-095, a crude drug containing red ginseng, polygala root, saffron, antelope horn and aloe wood. Our studies on rats and mice revealed a number of pharmacological properties of this novel drug. N-095 increased the forced swimming time in mice and prevented gastric ulcers in rats under restraint and water immersion stress conditions at 100 mg/kg or higher. It also prevented footpad swelling in rats treated with lambda-carrageenin and histamine-induced gastric ulcers in rats at 300 mg/kg or higher. Furthermore, N-095 augmented the sedative effect in mice induced by hexobarbital, which is characterized by a decreased spontaneous motor activity and a prolongation of sleeping time. N-095 also stimulated spontaneous contractility of the uterus in rats at 1000 mg/kg and 2000 mg/kg and prevented hemolysis of erythrocytes by heating. In contrast, N-095 had no effect on the respiratory or cardiovascular system or on water and electrolyte regulation in rats or mice. These results show that N-095 is a relatively safe drug for use as a nutrient or tonic.
authors.affiliation: Research Laboratories, Kyushin Pharmaceutical Co., Ltd., 1-31-7, Wada, Suginami-ku, Tokyo 166-0012, Japan. secdiv@kyushin.co.jp
authors.forename: Eiji
authors.initials: E
authors.lastname: Inoue
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Masamichi
authors.initials: M
authors.lastname: Shoji
authors.forename: Haruyo
authors.initials: H
authors.lastname: Tsuchida
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Sano
authors.forename: Chihiro
authors.initials: C
authors.lastname: Ito
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002351:Carrageenan; D003292:Convulsants; D027622:Crocus; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D004827:Epilepsy / Q000139:chemically induced / Q000188:drug therapy; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D006632:Histamine; D008297:Male; D051379:Mice; D005894:Panax; D010433:Pentylenetetrazole; D017933:Peripheral Nervous System / Q000187:drug effects; D018517:Plant Roots; D031801:Polygala; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy; D013550:Swimming; D014599:Uterus / Q000187:drug effects; D014882:Water-Electrolyte Balance / Q000187:drug effects
chemical_list: D003292:Convulsants; D004365:Drugs, Chinese Herbal; D006632:Histamine; D002351:Carrageenan; D010433:Pentylenetetrazole