title: Solitary parenchymal splenic recurrence of ovarian adenocarcinoma: a case report and review of the literature.
abstract: We report a rare case of solitary parenchymal splenic recurrence of epithelial ovarian cancer which developed 27 months after the initial treatment. The patient, a 53-year-old woman, with a history of breast cancer, underwent total abdominal hysterectomy bilateral salpingo-ophorectomy (TAH & BSO), omentectomy and pelvic lymph node sampling for a serous carcinoma of the ovaries (stage IIIB). She subsequently received 6 cycles of cisplatinum chemotherapy. During follow-up, rising CA 125 serum levels heralded the 6 x 6 cm parenchymal splenic lesion which was documented by CT scan. She underwent splenectomy after pneumococcal vaccination, sandostatin and chemoprophylaxis. Histopathological evaluation revealed metastatic parenchymal disease consistent with recurrent ovarian cancer. She remains alive and disease-free for 20 months since the last operation. Isolated parenchymal splenic lesions are very rare and may occur as a late recurrence in epithelial ovarian cancer. Splenectomy can be performed with acceptable morbidity and confers a substantial survival benefit to patients.
authors.affiliation: 1st Department of Gynecology, St Savas Hospital, Athens, Greece. tserkez@otenet.gr
authors.forename: Aliki
authors.initials: A
authors.lastname: Tserkezoglou
authors.forename: Sofia
authors.initials: S
authors.lastname: Kontou
authors.forename: George
authors.initials: G
authors.lastname: Hatjieleftheriou
authors.forename: Maria-Evangellia
authors.initials: ME
authors.lastname: Nikolaidou
authors.forename: George
authors.initials: G
authors.lastname: Plataniotis
authors.forename: Nikiforos
authors.initials: N
authors.lastname: Apostolikas
authors.forename: George
authors.initials: G
authors.lastname: Magiakos
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary* / Q000601:surgery; D002945:Cisplatin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D013156:Splenectomy; D013160:Splenic Neoplasms / Q000556:secondary* / Q000601:surgery
chemical_list: D002945:Cisplatin