title: [The effect of population density on the elimination dynamics of a recessive lethal mutation from experimental populations].
abstract: Dynamics of the elimination of the temperature-sensitive lethal mutation l(2)M167DTS from experimental populations of Drosophila melanogaster under permissive conditions (25 degrees C) was studied. We have shown a rapid elimination of the mutation from the populations, selection for fitness of heterozygous individuals, association of the selection with high larval density and with the direction of the cross that had produced the founder males of the l(2)M167DTS/+ population, and the effect of relative competitive ability of l(2)M167DTS/+ males on the efficiency of the mutation introduction. Modification systems were shown be involved in fitness selection under conditions of high larval density.
authors.affiliation: Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, 119334 Russia. kulikov@genego.com
authors.forename: A M
authors.initials: AM
authors.lastname: Kulikov
authors.forename: F
authors.initials: F
authors.lastname: Marec
authors.forename: V G
authors.initials: VG
authors.lastname: Mitrofanov
mesh_terms: D000818:Animals; D002875:Chromosomes / Q000235:genetics; D004331:Drosophila melanogaster; D005804:Genes, Lethal; D005808:Genes, Recessive; D006579:Heterozygote; D008297:Male; D011156:Population Density; D011157:Population Dynamics; D012641:Selection, Genetic