title: Majusculoic acid, a brominated cyclopropyl fatty acid from a marine cyanobacterial mat assemblage.
abstract: The novel antifungal compound majusculoic acid was isolated from a cyanobacterial mat microbial community. The structure of majusculoic acid was solved by interpretation of mass spectrometric and NMR data and conversion to the corresponding methyl ester. Majusculoic acid exhibits antifungal activity against Candida albicans ATCC 14503 (MIC 8 microM).
authors.affiliation: Department of Chemistry, University of California, Davis, California 95616, USA.
authors.forename: John B
authors.initials: JB
authors.lastname: Macmillan
authors.forename: Tadeusz F
authors.initials: TF
authors.lastname: Molinski
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001444:Bahamas; D002176:Candida albicans / Q000187:drug effects*; D000458:Cyanobacteria / Q000737:chemistry*; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006842:Hydrocarbons, Brominated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000935:Antifungal Agents; D005231:Fatty Acids, Unsaturated; D006842:Hydrocarbons, Brominated; C501145:majusculoic acid