[Platelets and platelet microparticles glycoprotein IIb/IIIa complex in patients with unstable angina].
Platelet activation is known to play a key role in pathogenesis of acute coronary syndrome (ACS). Platelet activation leads to increased numbers of glycoprotein (GP) IIb/IIIa complex on the platelet membrane. On the other side antiplatelet therapy in patient with unstable angina can suppress the actions of platelet.


OBJECTIVE
To estimate by flow cytometry GP IIb/IIIa expression on the platelets and platelet microparticles membrane.


METHODS
The study involved 21 patients with unstable angina, before (group B1) and after treatment (group B2). All subjects received aspirin, heparin (Clexane) and b-blocker. The control group consisted of 24 healthy subjects.


RESULTS
Patients with unstable angina in group B1 were by 12% higher expression of GP IIb/IIIa than control group (62.6 vs 55.1%). In group B2- before treatment- the percentage of platelet expressing GP IIb/IIIa was lower (60.1%) than in the group B1. In both groups, B1 and B2, percentage of platelet microparticles expressions GP IIb/IIIa was elevated 8.5% and it was significantly higher than in the control group (5.3%).


CONCLUSIONS
Our study show that patients with unstable angina had a higher expression GP IIb/IIIa on the platelets membrane and elevated percentage of platelet microparticles confirm platelet activation. There was no significantly different in platelet GP IIb/IIIa expression after the antiplatelet therapy in patients with unstable angina.
Dymicka-Piekarska
Violetta
V
Zakład Laboratoryjnej Diagnostyki Klinicznej Akademii Medycznej w Bialymstoku. vpiekarska@yahoo.com
Kemona
Halina
H
Butkiewicz
Anna
A
Bychowski
Jerzy
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000789:Angina, Unstable / Q000097:blood* / Q000188:drug therapy; D016022:Case-Control Studies; D005260:Female; D005434:Flow Cytometry; D015870:Gene Expression; D006801:Humans; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000378:metabolism*
D019039:Platelet Glycoprotein GPIIb-IIIa Complex