[Dependence of the concentration of the demi-maximal action of a channel blocker on the agonist concentration].
Based on the analysis of kinetic scheme of blocking of open channels at any number of blocker binding sites, the dependence of current on blocker concentration was found. A variant of this dependence for a trapping blocker was also found. The restrictions of the applicability of the Hill equation and the necessity of taking into account the dependence of the concentration of demi-maximal blocker action (IC50) on the concentration of agonist were shown.
Skorinkin
A I
AI
Valeev
N V
NV
Shaĭkhutdinova
A R
AR
D000465:Algorithms; D001665:Binding Sites; D023902:Chromosome Pairing / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D015640:Ion Channel Gating; D007473:Ion Channels / Q000037:antagonists & inhibitors* / Q000502:physiology; D007700:Kinetics; D008564:Membrane Potentials; D008954:Models, Biological
D007473:Ion Channels