title: Noradrenergic receptor mRNA expression in adult rat superficial dorsal horn and dorsal root ganglion neurons.
abstract: Noradrenaline (NAdr) has well documented analgesic actions at the level of the spinal cord. Released from bulbospinal projections onto superficial dorsal horn (SDH) neurons, NAdr modulates the excitability of these neurons through the activation of alpha1, alpha2 or beta adrenoceptors. This study utilised in situ hybridisation to determine the specific expression of adrenoceptors within adult rat lumbar SDH and dorsal root ganglion (DRG) neurons, and reports the presence of alpha1A, alpha1B, alpha2B, beta1 and beta2 adrenoceptor mRNA within SDH neurons, and the presence of alpha1A, alpha1B and alpha2C adrenoceptor mRNA within DRG neurons. The present study provides an insight into the modulation of sensory processing at the level of the spinal cord following adrenoceptor activation.
authors.affiliation: Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK. rnicholson@bio.warwick.ac.uk
authors.forename: R
authors.initials: R
authors.lastname: Nicholson
authors.forename: A K
authors.initials: AK
authors.lastname: Dixon
authors.forename: D
authors.initials: D
authors.lastname: Spanswick
authors.forename: K
authors.initials: K
authors.lastname: Lee
mesh_terms: D000818:Animals; D001933:Brain Stem / Q000378:metabolism; D004525:Efferent Pathways / Q000378:metabolism; D005727:Ganglia, Spinal / Q000378:metabolism*; D015870:Gene Expression / Q000502:physiology; D008297:Male; D009433:Neural Inhibition / Q000502:physiology; D009475:Neurons, Afferent / Q000378:metabolism*; D009619:Nociceptors / Q000502:physiology*; D009638:Norepinephrine / Q000378:metabolism*; D010146:Pain / Q000235:genetics / Q000378:metabolism; D020671:Posterior Horn Cells / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011941:Receptors, Adrenergic / Q000235:genetics*; D011942:Receptors, Adrenergic, alpha / Q000235:genetics; D011943:Receptors, Adrenergic, beta / Q000235:genetics; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D012333:RNA, Messenger; D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D009638:Norepinephrine