title: Crohn's disease diagnosed by wireless capsule endoscopy in adolescents with abdominal pain, protein-losing enteropathy, anemia and negative endoscopic and radiologic findings.
abstract: BACKGROUND
  Approximately one-fourth of new Crohn's disease diagnoses are made in individuals under the age of 20 years, in whom proximal Crohn's disease tends to be more common.
  
  
  OBJECTIVE
  To describe the role of wireless capsule endoscopy in diagnosing isolated small intestinal Crohn's disease in two adolescents.
  
  
  METHODS
  Wireless capsule endoscopy was performed in two adolescents with severe protein-losing enteropathy and negative standard diagnostic workup.
  
  
  RESULTS
  Wireless capsule endoscopy successfully diagnosed Crohn's disease with uncharacteristic presentations and negative radiographic and endoscopic findings in both patients.
  
  
  CONCLUSIONS
  The non-invasiveness and ease in performance of capsule endoscopy on an ambulatory basis make this diagnostic modality especially advantageous for children.
authors.affiliation: Division of Gastroenterology, Dana Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
authors.forename: Olga
authors.initials: O
authors.lastname: Barkay
authors.forename: Menachem
authors.initials: M
authors.lastname: Moshkowitz
authors.forename: Shimon
authors.initials: S
authors.lastname: Reif
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000293:Adolescent; D000740:Anemia / Q000209:etiology; D003424:Crohn Disease / Q000150:complications / Q000473:pathology*; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D006801:Humans; D008297:Male; D011504:Protein-Losing Enteropathies / Q000209:etiology