title: [Association of polymorphic markers of lipid metabolism genes with diabetic polyneuropathy in type 1 diabetes mellitus].
abstract: The aim of this study was the search of association with diabetic polyneuropathy of the polymorphic markers epsilon2/epsilon3/epsilon4 of apolipoprotein E (APOE) and I/D of apolipoprotein B (APOB) genes in groups of type 1 diabetes patients with diabetic polyneuropathy (n = 86) and without its clinical signs (n = 94). We have not found significant association with diabetic polyneuropathy (DPN) of epsilon2/epsilon3/epsilon4 marker of APOE gene. However the comparison of allele and genotype frequencies of I/D marker of APOB gene showed that the carriers of I allele and II genotype had higher risk (OR = 1.66 and 2.01, relatively; p < 0.027), whereas the carriers of D allele had lower risk of DPN (OR = 0.60; p < 0.018). Our findings show that APOB gene, encoding one of the main components of lipid metabolism system, is involved into the diabetic polyneuropathy development in type 1 diabetes mellitus.
authors.forename: O E
authors.initials: OE
authors.lastname: Voron'ko
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Iakunina
authors.forename: I A
authors.initials: IA
authors.lastname: Strokov
authors.forename: I N
authors.initials: IN
authors.lastname: Lavrova
authors.forename: V V
authors.initials: VV
authors.lastname: Nosikov
mesh_terms: D000293:Adolescent; D000328:Adult; D001057:Apolipoproteins E / Q000378:metabolism*; D003929:Diabetic Neuropathies / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic
chemical_list: D001057:Apolipoproteins E; D005819:Genetic Markers