title: Prevalence of hepatitis-B surface antigen among blood donors and human immunodeficiency virus-infected patients in Jos, Nigeria.
abstract: Information is very scarce on the prevalence of hepatitis-B virus (HBV) infection among blood donors and patients with human immunodeficiency virus (HIV) infection in Nigeria. Hepatitis-B surface antigen (HBsAg) ELISA was used to determined the prevalence of HBsAg among 175 blood donors (aged 20-40 years) and 490 HIV-infected patients (aged 17-60 years) in Jos, Nigeria. Twenty-five (14.3%) of the blood donors and 127 (25.9%) of the HIV-infected individuals were HBsAg seropositive, indicating a higher HBV infection among HIV-infected persons than among healthy blood donors. A slightly higher HBsAg seroprevalence was recorded in the males (14.6%) than females (12.9%) of the blood donors. Among the HIV-infected patients, the males had considerably higher HBsAg seroprevalence than the females (31.8 vs 22.1%) with the highest prevalence of HBsAg occurring in the 51-60 years age group (44%), followed by those of 31-40 years (28.2%). Results confirmed the high endemicity of HBV infection in Jos, Nigeria and the significantly greater prevalence of HBV infection among HIV-infected patients than among blood donors.
authors.affiliation: Department of Medical Microbiology, Faculty of Clinical Medicine, College of Health Sciences, Ebonyi State University, PMB 053, Abakaliki, Nigeria. unekecj@yahoo.com
authors.forename: C J
authors.initials: CJ
authors.lastname: Uneke
authors.forename: O
authors.initials: O
authors.lastname: Ogbu
authors.forename: P U
authors.initials: PU
authors.lastname: Inyama
authors.forename: G I
authors.initials: GI
authors.lastname: Anyanwu
authors.forename: M O
authors.initials: MO
authors.lastname: Njoku
authors.forename: J H
authors.initials: JH
authors.lastname: Idoko
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D001782:Blood Donors; D015897:Comorbidity; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015658:HIV Infections / Q000453:epidemiology*; D006509:Hepatitis B / Q000175:diagnosis / Q000453:epidemiology*; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D015995:Prevalence; D016036:Seroepidemiologic Studies
chemical_list: D006514:Hepatitis B Surface Antigens