Majusculoic acid, a brominated cyclopropyl fatty acid from a marine cyanobacterial mat assemblage.
The novel antifungal compound majusculoic acid was isolated from a cyanobacterial mat microbial community. The structure of majusculoic acid was solved by interpretation of mass spectrometric and NMR data and conversion to the corresponding methyl ester. Majusculoic acid exhibits antifungal activity against Candida albicans ATCC 14503 (MIC 8 microM).
Macmillan
John B
JB
Department of Chemistry, University of California, Davis, California 95616, USA.
Molinski
Tadeusz F
TF
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001444:Bahamas; D002176:Candida albicans / Q000187:drug effects*; D000458:Cyanobacteria / Q000737:chemistry*; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006842:Hydrocarbons, Brominated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
D000935:Antifungal Agents; D005231:Fatty Acids, Unsaturated; D006842:Hydrocarbons, Brominated; C501145:majusculoic acid