title: [HOXB gene family and functions of hematopoietic stem/progenitor cells--review].
abstract: Recently, many researches indicated the important role played by homeobox (HOX) gene family in normal hematopoiesis. As a kind of transcription factors, HOX gene products regulate and control the expression of target genes by binding to special DNA sequences. HOXB, a member of HOX gene family, especially HOXB(4), interests people greatly. It has been found that its expression relates closely to the self-renewal of hematopoietic stem cells and effective proliferation of hematopoietic progenitor cells. This review presents some new research progress in this area.
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. yuhongtang@sina.com
authors.forename: Yu-Hong
authors.initials: YH
authors.lastname: Tang
authors.forename: Cheng-Ya
authors.initials: CY
authors.lastname: Wang
mesh_terms: D000818:Animals; D006410:Hematopoiesis / Q000235:genetics / Q000276:immunology / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D018398:Homeodomain Proteins / Q000235:genetics* / Q000502:physiology; D006801:Humans; D005810:Multigene Family
chemical_list: D018398:Homeodomain Proteins