Genetic imprinting: conflict at the Callipyge locus.
The imprinted Dlk1-Gtl2 region of the mammalian genome - which in sheep encompasses the Callipyge locus, known for its unusual mode of inheritance - encodes a number of maternally expressed miRNAs. Five of these miRNAs, hosted by the antisense transcript antiPeg11, have now been shown to target degradation of the paternally expressed Peg11 mRNA by an RNAi-mediated mechanism.
Lewis
Annabelle
A
Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK.
Redrup
Lisa
L
D000818:Animals; D040461:Gene Components; D018392:Genomic Imprinting / Q000235:genetics*; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D040582:Inheritance Patterns / Q000235:genetics; D008322:Mammals / Q000235:genetics* / Q000254:growth & development; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D009154:Mutation / Q000235:genetics; D011506:Proteins / Q000235:genetics*; D034622:RNA Interference; D062085:RNA, Long Noncoding; D012333:RNA, Messenger / Q000378:metabolism*
D006023:Glycoproteins; C498907:MEG3 non-coding RNA, human; D035683:MicroRNAs; D011506:Proteins; D062085:RNA, Long Noncoding; D012333:RNA, Messenger