Synthesis of lactams via copper-catalyzed intramolecular vinylation of amides.
Copper-catalyzed intramolecular vinylation of iodoenamides were investigated for the first time. With CuI as the catalyst and N,N'-dimethylethylenediamine as the ligand, a number of iodoenamides underwent cyclization in dioxane leading to the formations of five- to seven-membered lactams in moderate to excellent yields.
Hu
Tianshun
T
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, P. R. China.
Li
Chaozhong
C
D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D007769:Lactams / Q000138:chemical synthesis*; D015394:Molecular Structure
D000577:Amides; D007769:Lactams; D003300:Copper