In vitro suppression of latent HIV-1 activation by vitamin E: potential clinical implications.
We evaluated the effect of vitamin E in controlling HIV-1 production upon activation of the patients' reservoir of resting CD4 lymphocytes in tissue culture experiments. The addition of vitamin E to patients' cultures resulted in significantly reduced levels of p24 virus production (P = 0.0015). These results suggest that vitamin E supplementation may interfere with the emergence of drug-resistant HIV-1 variants archived in the resting cell reservoir and delay or limit virus rebound upon treatment interruptions.
Heredia
Alonso
A
Division of Clinical Research, Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, MD, USA.
Davis
Charles
C
Amoroso
Anthony
A
Taylor
Greg
G
Le
Nhut
N
Bamba
Douty
D
Redfield
Robert R
RR
D000975:Antioxidants / Q000627:therapeutic use*; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D002478:Cells, Cultured; D003864:Depression, Chemical; D016655:HIV Core Protein p24 / Q000032:analysis; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D017735:Virus Latency / Q000187:drug effects; D014810:Vitamin E / Q000627:therapeutic use*
D000975:Antioxidants; D016655:HIV Core Protein p24; D014810:Vitamin E