title: Could intraoperative analgesia attenuate excessive neuroendocrine responses in surgical patients?
abstract: Recently, there has been increasing interest among anesthesiologists in the responses to surgical stress because
  surgical procedures have become more and more invasive. While the responses are natural and
  protective in themselves, they may have adverse consequences for the patients. There have been many
  investigations suggesting that anesthetic techniques such as spinal and epidural analgesia may alter the endocrine
  response. Some measures which block inflammatory reaction are reported to allow modulation of
  the response.' In the present study preemptive analgesia for postoperative pain using spinal and extradural
  blockade, and pre-treatment of cyclo-oxygenase inhibitor indomethacin were applied to patients
  responses were assessed.
authors.affiliation: Department of Anesthesiology, Nippon Medical School, Tokyo, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Ogawa
authors.forename: A
authors.initials: A
authors.lastname: Ogura
authors.forename: C
authors.initials: C
authors.lastname: Kim
authors.forename: M
authors.initials: M
authors.lastname: Yamaguchi