title: [Structural analysis of the complex of phenoxazone antibiotic actinocyl-bis-(2-deoxytetranucleotide 5'-d(TpGpCpA) by the methods of two dimensional 1H-NMR-spectroscopy and molecular mechanics].
abstract: The spatial structures of intercalated complexes of synthetic phenoxazone antibiotic actinocyl-bis-(2-dimethylaminoethyl) amide with self-complementary deoxytetranucleotide 5'-d(TpGpCpA) have been investigated. Analysis has been made using two-dimensional NMR (2D-NOESY) data in aqueous solution and molecular mechanics simulation. Distinctive features of the conformation of drug-DNA complexes have been determined at two possible orientations of the chromophore of phenoxazone antibiotic at the intercalation site.
authors.forename: A N
authors.initials: AN
authors.lastname: Veselkov
authors.forename: L N
authors.initials: LN
authors.lastname: Djimant
authors.forename: K A
authors.initials: KA
authors.lastname: Veselkov
authors.forename: D V
authors.initials: DV
authors.lastname: Davis
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D015394:Molecular Structure; D009711:Nucleotides / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D009711:Nucleotides