[Some microcirculatory and metabolic changes of rat myocardium following coronary artery occlusion].
The experiments conducted on 50 albino male rats have shown that the increase of capillary metabolic surface area and capillary bed capacity detected 1-15 days after the coronary artery occlusion in the zones distant from necrotic focus, and resulting mainly from capillary dilation, correlated with the progressive reduction of lipid peroxidation intensity, decline in the necrotic focus area and in the activity of necrotic marker enzymes in blood serum. These changes were accompanied by a gradual increase in the activity of some enzymes and substrate content that characterize the myocardial energy supply. The changes detected could be regarded as a result of improvement of microcirculatory blood supply to the myocardium. while a prolonged (lasting for 15 days) increase of myocardial lipid peroxide content could reflect the natural reoxygenation arising from a collateral circulation development.
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D000818:Animals; D002196:Capillaries / Q000473:pathology; D003327:Coronary Disease / Q000378:metabolism / Q000473:pathology*; D015227:Lipid Peroxidation; D008297:Male; D051379:Mice; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology*; D051381:Rats