Phytosterols in nonfat and low-fat beverages have no impact on the LDL size phenotype.
OBJECTIVE
To examine the impact of nonfat and low-fat phytosterol-enriched beverages on low-density lipoprotein (LDL) electrophoretic characteristics.


METHODS
Double-blind, randomized, crossover, placebo-controlled dietary trial.


METHODS
Diets were prepared and consumed at the Mary Emily Clinical Nutrition Research Unit of McGill University. Analyses were performed at the Institute on Nutraceuticals and Functional Foods of Laval University.


METHODS
In total, 15 moderately hypercholesterolemic persons consumed each of three experimental diets that each comprised a different beverage: nonfat placebo (NF control), nonfat with phytosterols (NFPS) or low-fat with phytosterols (LFPS). Participants consumed three beverages daily at meal time for a total of 1.8 g of phytosterols per day. Nondenaturing 2-16% polyacrylamide gradient gel electrophoreses were used to characterize LDL size characteristics.


RESULTS
The NFPS and LFPS beverage induced no significant changes in several features of the LDL size phenotype compared to the control diet.


CONCLUSIONS
The consumption of phytosterol-supplemented nonfat and low-fat beverages is not associated with clinically meaningful changes in the LDL particle size phenotype.
Charest
A
A
Institute on Nutraceuticals and Functional Foods, Laval University, Québec, Canada.
Vanstone
C
C
St-Onge
M P
MP
Parson
W
W
Jones
P J H
PJ
Lamarche
B
B
D000328:Adult; D000368:Aged; D001628:Beverages; D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects*; D018592:Cross-Over Studies; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D058870:Food, Organic; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D010641:Phenotype; D010840:Phytosterols / Q000008:administration & dosage / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004041:Dietary Fats; D010840:Phytosterols; D014280:Triglycerides