title: High-speed capillary gas chromatography for determination of inhalation anesthetics.
abstract: To increase sample throughput for GC analysis of inhalation anaesthetics without affecting the separation of nitrous oxide (N2O) and halogenated anaesthetics (sevoflurane, isoflurane and halothane), we explored the effectiveness of a tailor-shortened (12 m) PlotQ capillary column and developed a high-speed version of a previously reported GC technique (involving chromatographic separation of analytes using a GC-MS system, coupled with a selected ion monitoring (SIM) method to increase sensitivity). Efficient separation and repeatable results were achieved at a reduced runtime of approximately 7 min (versus 18 min with the original method) at a carrier gas flow of 1.5 ml/min. This approach should more than double the previous throughput.
authors.affiliation: Safety, Hygiene and Occupational Medicine Service, University of Bologna, Via Pelagio Palagi 9, Bologna 40138, Italy. antonio.accorsi@unibo.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Accorsi
authors.forename: Barbara
authors.initials: B
authors.lastname: Morrone
authors.forename: Giovanni Battista
authors.initials: GB
authors.lastname: Raffi
authors.forename: Francesco Saverio
authors.initials: FS
authors.lastname: Violante
mesh_terms: D018685:Anesthetics, Inhalation / Q000032:analysis*; D002849:Chromatography, Gas / Q000379:methods*; D012015:Reference Standards; D012680:Sensitivity and Specificity
chemical_list: D018685:Anesthetics, Inhalation