title: Influence of interleukin-10 on Aspergillus fumigatus infection in patients with cystic fibrosis.
abstract: Recent evidence suggests that genetic polymorphisms that affect the production of interleukin (IL)-10 may play a role in the response to pathogens in cystic fibrosis (CF). The present study was designed to investigate a possible association between alleles carried at position -1082 in the promoter region of the IL-10 gene and clinical data on 378 patients with CF. After adjustment for potential confounding variables, a significant relationship was found between the -1082GG genotype and both colonization with Aspergillus fumigatus and allergic bronchopulmonary aspergillosis. In addition, higher serum levels of IL-10 were observed in patients colonized with A. fumigatus. These results suggest that polymorphisms in the promoter region of the IL-10 gene may influence the host response to A. fumigatus in the context of CF.
authors.affiliation: Inserm E213, Armand Trousseau Hospital, Paris, and the Department of Pediatrics, Georges Clemenceau Hospital, Caen, France. brouard-j@chu-caen.fr
authors.forename: Jacques
authors.initials: J
authors.lastname: Brouard
authors.forename: Nicola
authors.initials: N
authors.lastname: Knauer
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Boelle
authors.forename: Harriet
authors.initials: H
authors.lastname: Corvol
authors.forename: Alexandra
authors.initials: A
authors.lastname: Henrion-Caude
authors.forename: Cyril
authors.initials: C
authors.lastname: Flamant
authors.forename: François
authors.initials: F
authors.lastname: Bremont
authors.forename: Bertrand
authors.initials: B
authors.lastname: Delaisi
authors.forename: Jean-Francois
authors.initials: JF
authors.lastname: Duhamel
authors.forename: Christophe
authors.initials: C
authors.lastname: Marguet
authors.forename: Michel
authors.initials: M
authors.lastname: Roussey
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Miesch
authors.forename: Katarina
authors.initials: K
authors.lastname: Chadelat
authors.forename: Michele
authors.initials: M
authors.lastname: Boule
authors.forename: Brigitte
authors.initials: B
authors.lastname: Fauroux
authors.forename: Felix
authors.initials: F
authors.lastname: Ratjen
authors.forename: Hartmut
authors.initials: H
authors.lastname: Grasemann
authors.forename: Annick
authors.initials: A
authors.lastname: Clement
mesh_terms: D000293:Adolescent; D001228:Aspergillosis / Q000276:immunology*; D001232:Aspergillus fumigatus; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008172:Lung Diseases, Fungal / Q000276:immunology*; D011110:Polymorphism, Genetic / Q000276:immunology*
chemical_list: D016753:Interleukin-10