title: Tuning the enantioselective N-acetylation of racemic amines: a spectacular salt effect.
abstract: We have described a spectacular salt effect in the kinetic resolution of (+/-)-1-phenylethylamine, which leads to an increase in reactivity, high levels of selectivity, and a complete reversal of the stereoselectivity. By tuning the reaction conditions, we were able to increase the selectivity factor of (1S,2S)-1 to s = 115.
authors.affiliation: Laboratoire de Synthèse Bio-Organique associé au CNRS, Université Louis Pasteur de Strasbourg, Faculté de Pharmacie, 74 route du Rhin, 67401 Illkirch-Graffenstaden, France.
authors.forename: Stellios
authors.initials: S
authors.lastname: Arseniyadis
authors.forename: Pithani V
authors.initials: PV
authors.lastname: Subhash
authors.forename: Alain
authors.initials: A
authors.lastname: Valleix
authors.forename: Suju P
authors.initials: SP
authors.lastname: Mathew
authors.forename: Donna G
authors.initials: DG
authors.lastname: Blackmond
authors.forename: Alain
authors.initials: A
authors.lastname: Wagner
authors.forename: Charles
authors.initials: C
authors.lastname: Mioskowski