title: An acute inflammatory response alters bone homeostasis, body composition, and the humoral immune response of broiler chickens.
abstract: To quantify the effects of an acute phase response in broilers, chicks were injected with 1 mg/kg Escherichia coli lipopolysaccharide (LPS) at 15 and 23 d. Lipopolysaccharide injection increased feed/gain (P = 0.03), increased liver weight (P = 0.09), and decreased tibia calcium (P = 0.05) and breaking strength (P < 0.04) by d 28. In a second experiment, 3 d postinjection of chicks at d 31, LPS decreased BW (P < 0.01), breast weight (P = 0.08), and tibia breaking strength (P = 0.05), and increased liver weight (P < 0.01), mortality (P = 0.05), and titers to bronchitis and Mycoplasma gallisepticum that were induced by vaccination at hatch or by field exposure, respectively (P = 0.04). For experiment 3, chicks were challenged with LPS at 23d and 27d. Lipopolysaccharide-injected chicks had decreased BW (P = 0.06), feed consumption (P = 0.05), tibia weight (P< 0.01), and breaking strength (P < 0.01), and increased feed/gain (P < 0.01), liver weight (P < 0.01), and plasma ionized calcium level (P = 0.08). For experiment 4, chicks were injected with 0, 0.33, 0.66, 1.00, or 4.25 mg of LPS/kg of BW. There was an inverse relationship between LPS level and BW or bone breaking strength. Experiment 5 compared 4 broiler strains. Strain x LPS interactions were found for bone breaking strength (P = 0.01). Mortality before LPS challenge was inversely correlated to liver weight (r2 = 0.95, P = 0.02) and bone breaking strength (r2 = 0.99, P = 0.01) only after an LPS challenge.
authors.affiliation: Foster Farms, Department of Feed Research, Modesto, California, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Mireles
authors.forename: S M
authors.initials: SM
authors.lastname: Kim
authors.forename: K C
authors.initials: KC
authors.lastname: Klasing
mesh_terms: D000210:Acute-Phase Reaction / Q000139:chemically induced / Q000276:immunology / Q000503:physiopathology / Q000662:veterinary*; D000818:Animals; D000917:Antibody Formation / Q000502:physiology; D001823:Body Composition / Q000502:physiology*; D001835:Body Weight / Q000502:physiology; D001842:Bone and Bones / Q000502:physiology*; D002645:Chickens / Q000276:immunology / Q000502:physiology*; D004926:Escherichia coli; D006706:Homeostasis / Q000502:physiology; D008070:Lipopolysaccharides; D008099:Liver / Q000502:physiology; D009929:Organ Size / Q000502:physiology; D011201:Poultry Diseases / Q000276:immunology / Q000503:physiopathology*
chemical_list: D008070:Lipopolysaccharides