title: Increased expression of histone deacetylase 2 is found in human gastric cancer.
abstract: Accumulated evidence has established that aberrant regulation of histone deacetylases (HDACs) is one of the major causes of the development of human malignancies. Among different iso-enzymes of HDAC and sirtuins grouped as the HDAC super family, little is known as to how histone deacetylase 2 (HDAC2) causes carcinogenesis in solid tumors. Here, in order to investigate the possible role of HDAC2 in gastric carcinogenesis, we analyzed the expression of HDAC2 in 71 gastric adenocarcinomas by immunohistochemistry. Moderate to strong expression of HDAC2 was found in 44 (62%) out of a total of 71 tumors. The majority of positive tumors, which were detected in the nucleus but not in normal gastric epithelium, did not express HDAC2 or showed only weak positive staining. Interestingly, we also noted that HDAC2 expression appeared to be associated with tumor aggressiveness as HDAC2 expression was observed to be statistically significant in advanced gastric cancer (P=0.0023, Chi-square test) and in positive lymph node metastasis (P=0.0713, Chi-square test). Taken together, these results suggest that HDAC2 may play an important role in the aggressiveness of gastric cancer.
authors.affiliation: Department of Pathology, Microdissection Genomics Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Jaehwi
authors.initials: J
authors.lastname: Song
authors.forename: Ji Heon
authors.initials: JH
authors.lastname: Noh
authors.forename: Jong Heun
authors.initials: JH
authors.lastname: Lee
authors.forename: Jung Woo
authors.initials: JW
authors.lastname: Eun
authors.forename: Young Min
authors.initials: YM
authors.lastname: Ahn
authors.forename: Su Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Sug Hyung
authors.initials: SH
authors.lastname: Lee
authors.forename: Won Sang
authors.initials: WS
authors.lastname: Park
authors.forename: Nam Jin
authors.initials: NJ
authors.lastname: Yoo
authors.forename: Jung Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Suk Woo
authors.initials: SW
authors.lastname: Nam
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D002467:Cell Nucleus / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D056464:Histone Deacetylase 2; D006655:Histone Deacetylases / Q000096:biosynthesis / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D009361:Neoplasm Invasiveness; D012097:Repressor Proteins / Q000096:biosynthesis / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D012097:Repressor Proteins; D056464:Histone Deacetylase 2; D006655:Histone Deacetylases