title: A blinded, randomized, controlled study on the effect of buffered 0.9% and 3% sodium chloride intranasal sprays on ciliary beat frequency.
abstract: BACKGROUND
  There are conflicting reports regarding the effect of intranasal saline sprays on the various components of the mucociliary clearance system. This study evaluates the effect of normal saline and hypertonic saline on the ciliary beat frequency (CBF).
  
  
  METHODS
  Eight healthy volunteers were randomized to receive 0.9% saline spray to one nostril and 3.0% saline spray to the other. Ciliated cells were collected, and the CBF was calculated using computerized microphotometry.
  
  
  RESULTS
  Although neither solution significantly altered the CBF from baseline measurements, there was a significant difference between the CBFs of the two solutions at 5 minutes postadministration (9.1 Hz with 0.9% saline, 10.1 Hz with 3.0% saline, P < .05). This was a transient effect and was not seen when cells were examined at 60 minutes postadministration.
  
  
  CONCLUSIONS
  The administration of hypertonic saline results in a significantly faster CBF 5 minutes after administration. This effect is not seen 60 minutes after administration.
authors.affiliation: Department of Surgery, Otolaryngology-Head and Neck Surgery, Adelaide and Flinders Universities, Adelaide, South Australia.
authors.forename: David A M
authors.initials: DA
authors.lastname: Wabnitz
authors.forename: Peter-John
authors.initials: PJ
authors.lastname: Wormald
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D009079:Mucociliary Clearance / Q000187:drug effects* / Q000502:physiology; D009296:Nasal Cavity; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000503:physiopathology; D012220:Rhinitis / Q000188:drug therapy / Q000503:physiopathology; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage / Q000494:pharmacology*; D007507:Therapeutic Irrigation
chemical_list: D012462:Saline Solution, Hypertonic