title: Laser diffraction for standardization of heterogeneous pharmaceutical preparations.
abstract: A new quantitative method for standardization of heterogeneous pharmaceutical preparations and their quality control during storage based on laser diffraction is proposed. A series of pharmaceutical dosage forms--suspensions, emulsions, tinctures, decoctions, cell preparations and others, are heterogeneous medicines. In some cases disperse phase can be formed during storage as a result of layering (L1/L2) or precipitation (S/L). Laser diffraction method proposed in this study can be used for standardization and quality control of medicines.
authors.affiliation: Department of Pharmaceutical and Toxicological Chemistry, Faculty of Medicine, Peoples Friendship University of Russia, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Syroeshkin
authors.forename: P I
authors.initials: PI
authors.lastname: Popov
authors.forename: T V
authors.initials: TV
authors.lastname: Grebennikova
authors.forename: V A
authors.initials: VA
authors.lastname: Frolov
authors.forename: T V
authors.initials: TV
authors.lastname: Pleteneva
mesh_terms: D007834:Lasers / Q000592:standards; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000592:standards*; D012015:Reference Standards
chemical_list: D004364:Pharmaceutical Preparations