title: The Danish National Schizophrenia Project: prospective, comparative longitudinal treatment study of first-episode psychosis.
abstract: BACKGROUND
  First-episode psychosis intervention may improve the course and outcome of schizophrenic disorders.
  
  
  OBJECTIVE
  To describe the Danish National Schizophrenia Project and to measure the outcome of two different forms of intervention after 1 year, compared with standard treatment.
  
  
  METHODS
  A prospective, prospective, longitudinal, multicentre investigation included 562 patients, consecutively referred over a 2-year period, with a first episode of psychosis. Patients were allocated to supportive psychodynamic psychotherapy as a supplement to treatment as usual, an integrated, assertive, psychosocial and educational treatment programme or treatment as usual.
  
  
  RESULTS
  There was a non-significant tendency towards greater improvement in social functioning in the integrated treatment group and the supportive psychodynamic psychotherapy group compared with the treatment as usual group. Significance was reached for some measures when the confounding effect of drug and alcohol misuse was included.
  
  
  CONCLUSIONS
  Integrated treatment and supportive psychodynamic psychotherapy in addition to treatment as usual may improve outcome after 1 year of treatment for people with first-episode psychosis, compared with treatment as usual alone.
authors.affiliation: Centre of Psychiatry Glostrup, Unit for Psychotherapy, Education and Research, University of Copenhagen, Ndr.Ringvej, DK-2600 Glostrup, Denmark. bros@glostruphosp.kbhamt.dk
authors.forename: Bent
authors.initials: B
authors.lastname: Rosenbaum
authors.forename: Kristian
authors.initials: K
authors.lastname: Valbak
authors.forename: Susanne
authors.initials: S
authors.lastname: Harder
authors.forename: Per
authors.initials: P
authors.lastname: Knudsen
authors.forename: Anne
authors.initials: A
authors.lastname: Køster
authors.forename: Matilde
authors.initials: M
authors.lastname: Lajer
authors.forename: Anne
authors.initials: A
authors.lastname: Lindhardt
authors.forename: Gerda
authors.initials: G
authors.lastname: Winther
authors.forename: Lone
authors.initials: L
authors.lastname: Petersen
authors.forename: Per
authors.initials: P
authors.lastname: Jørgensen
authors.forename: Merete
authors.initials: M
authors.lastname: Nordentoft
authors.forename: Anne Helms
authors.initials: AH
authors.lastname: Andreasen
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D008137:Longitudinal Studies; D008297:Male; D011446:Prospective Studies; D011613:Psychotherapy / Q000379:methods*; D012559:Schizophrenia / Q000628:therapy*
chemical_list: D014150:Antipsychotic Agents