[ADP-ribosylation intensifies cleavage of DNA loops in the nuclear matrix].
Using DNA pulse field electrophoresis it has been shown that ADP-ribosylation in the nucleoids of human mononuclear leukocytes and rat brain cortex neurons stimulates cleavage of DNA loops at their attachmant sites to the nuclear matrix. The conclusion has been drawn suggesting possible participation of ADP-ribosylation in DNA-topoisomerase II activity modulation in the nuclear matrix of eukaryotic cells.
Zaalishvili
G T
GT
Tsetskhladze
Z R
ZR
Margiani
D O
DO
Gabriadze
I Iu
IIu
Zaalishvili
T M
TM
D000246:Adenosine Diphosphate Ribose / Q000378:metabolism*; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D016521:Electrophoresis, Gel, Pulsed-Field; D006801:Humans; D006868:Hydrolysis; D008214:Lymphocytes / Q000378:metabolism; D015530:Nuclear Matrix / Q000378:metabolism*; D051381:Rats
D000246:Adenosine Diphosphate Ribose; D004247:DNA