[A case of an elderly type 2 diabetes who had severe diabetic nephropathy without retinopathy].
We encountered a man who developed severe diabetic nephropathy without progression of diabetic retinopathy. He had a 14-year history of diabetes, and had been treated with sulfonylurea, and his HbA1c remained around 6.5%. He was admitted because of systemic edema and dyspnea on effort Laboratory data revealed renal failure and nephrotic syndrome, whereas there was no symptom of diabetic retinopathy. Since diabetic nephropathy usually progresses in parallel with retinopathy, it is atypical to develop severe nephropathy without retinopathy. In this case, longstanding hypertension and his genetic background including angiotensin converting enzyme D/I polymorphism might have played an important role in development of diabetic nephropathy.
Koshizaka
Masaya
M
Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine.
Maezawa
Yoshiro
Y
Kawamura
Harukiyo
H
Kobayashi
Kazuki
K
Fujimoto
Masaki
M
Asaumi
Sunao
S
Hashimoto
Naotake
N
Mori
Seijiro
S
Yokote
Koutaro
K
Saito
Yasushi
Y
D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003928:Diabetic Nephropathies / Q000209:etiology* / Q000235:genetics*; D018450:Disease Progression; D006801:Humans; D006977:Hypertension, Renal / Q000150:complications; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic
D007703:Peptidyl-Dipeptidase A