title: The 6-derivative of beta-cyclodextrin with succinic acid: a new chiral selector for CD-EKC.
abstract: 6-O-Succinil-beta-cyclodextrin (CDsuc6) was synthesized with very good yield by one pot synthesis and characterized by NMR spectroscopy and ESI-MS. It was used as a chiral selector in capillary electrophoresis to resolve catecholamine racemates, namely norepinephrine, epinephrine, terbutaline and norphenilephrine. The CE experiments at pH 5.6 show very promising selector ability by 6-O-succinil-beta-cyclodextrin for the chiral recognition of all the catecholamines tested, while at pH 9.2, only racemic terbutaline was successfully separated.
authors.affiliation: Department of Chemical Sciences, University of Catania, Viale A.Doria 6, 95125 Catania, Italy. ecucinotta@unict.it
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Cucinotta
authors.forename: Alessandro
authors.initials: A
authors.lastname: Giuffrida
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Maccarrone
authors.forename: Marianna
authors.initials: M
authors.lastname: Messina
authors.forename: Antonino
authors.initials: A
authors.lastname: Puglisi
authors.forename: Alberto
authors.initials: A
authors.lastname: Torrisi
authors.forename: Graziella
authors.initials: G
authors.lastname: Vecchio
mesh_terms: D002845:Chromatography / Q000379:methods; D003505:Cyclodextrins / Q000032:analysis; D004563:Electrochemistry; D008968:Molecular Conformation; D019802:Succinic Acid / Q000032:analysis* / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000032:analysis* / Q000737:chemistry*
chemical_list: D003505:Cyclodextrins; D047392:beta-Cyclodextrins; D019802:Succinic Acid; C031215:betadex