Efficient batch and continuous flow Suzuki cross-coupling reactions under mild conditions, catalysed by polyurea-encapsulated palladium (II) acetate and tetra-n-butylammonium salts.
Suzuki cross-coupling reactions are effected in both conventional organic solvents, under continuous flow conditions at 70 degree C, and in batch mode in supercritical carbon dioxide (scCO2), at temperatures as low as 40 degrees C in the presence of palladium(II) acetate microencapsulated in polyurea [PdEnCat] and tetra-n-butylammonium salts.
Lee
Connie K Y
CK
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK.
Holmes
Andrew B
AB
Ley
Steven V
SV
McConvey
Ian F
IF
Al-Duri
Bushra
B
Leeke
Gary A
GA
Santos
Regina C D
RC
Seville
Jonathan P K
JP
D000085:Acetates / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002245:Carbon Dioxide / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D012492:Salts / Q000737:chemistry; D013696:Temperature
D000085:Acetates; D001713:Biphenyl Compounds; D009942:Organometallic Compounds; D011108:Polymers; D000644:Quaternary Ammonium Compounds; D012492:Salts; C516071:palladium(II) acetate; D002245:Carbon Dioxide; C045786:polyurea; C009405:tetrabutylammonium