Cyclic peptides of the nocardamine class from a marine-derived bacterium of the genus Streptomyces.
Two new cyclic peptides (2 and 3) along with the previously reported nocardamine (1) were isolated from the culture broth of an actinomycete of the genus Streptomyces isolated from an unidentified marine sponge. On the basis of the results of combined spectral analyses, the structures of the new compounds were defined to be the dehydroxy and desmethylenyl derivatives of nocardamine, respectively. The new compounds exhibited weak inhibition against the enzyme sortase B.
Lee
Hyi-Seung
HS
Marine Natural Products Laboratory, Korea Ocean Research and Development Institute, Ansan P.O. Box 29, Seoul 425-600, Korea.
Shin
Hee Jae
HJ
Jang
Kyoung Hwa
KH
Kim
Tae Sik
TS
Oh
Ki-Bong
KB
Shin
Jongheon
J
D019881:Aminoacyltransferases / Q000037:antagonists & inhibitors; D000818:Animals; D001419:Bacteria / Q000187:drug effects*; D001426:Bacterial Proteins; D003546:Cysteine Endopeptidases; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000145:classification / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera; D013302:Streptomyces / Q000737:chemistry*
D001426:Bacterial Proteins; D004791:Enzyme Inhibitors; D010456:Peptides, Cyclic; C501152:dehydroxynocardamine; C501153:desmethylenylnocardamine; D019881:Aminoacyltransferases; C120542:sortase A; D003546:Cysteine Endopeptidases; C033516:deferrioxamine E