title: Increasing incidence of Barrett's oesophagus in the general population.
abstract: BACKGROUND
  Barrett's oesophagus (BO) predisposes to oesophageal adenocarcinoma. Epidemiological data suggest that the incidence of BO is rising but it is unclear whether this reflects a true rise in incidence of BO or an increase in detection secondary to more upper gastrointestinal endoscopies performed. This study aimed to examine the changes in BO incidence relative to the number of upper gastrointestinal endoscopies performed in the general population.
  
  
  METHODS
  We conducted a cohort study using the Integrated Primary Care Information database. This general practice research database contains the complete and longitudinal electronic medical records of more than 500,000 persons.
  
  
  RESULTS
  In total, 260 incident cases of BO were identified during the study period. The incidence of BO increased from 14.3/100,000 person years in 1997 (95% confidence interval (CI) 8.6-22.4) to 23.1/100,000 person years (95% CI 17.2-30.6) in 2002 (r2 = 0.87). The number of upper gastrointestinal endoscopies decreased from 7.2/1000 person years (95% CI 6.7-7.7) to 5.7/1000 person years (95% CI 5.4-6.1) over the same time period. This resulted in an overall increase in detected BO per 1000 endoscopies from 19.8 (95% CI 12.0-31.0) in 1997 to 40.5 (95% CI 30.0-53.5) in 2002 (r2 = 0.93). The incidence of adenocarcinoma increased from 1.7/100,000 person years (95% CI 0.3-5.4) in 1997 to 6.0/100,000 person years (95% CI 3.3-10.2) in 2002 (r2 = 0.87).
  
  
  CONCLUSIONS
  The incidence of diagnosed BO is increasing, independent of the number of upper gastrointestinal endoscopies that are being performed. This increase in BO incidence will likely result in a further increase in the incidence of oesophageal adenocarcinomas in the near future.
authors.affiliation: Department of Gastroenterology and Hepatology, Erasmus University Medical Centre, Postbus 2040, 3000 CA Rotterdam, Netherlands. e.vansoest@erasmusmc.nl
authors.forename: E M
authors.initials: EM
authors.lastname: van Soest
authors.forename: J P
authors.initials: JP
authors.lastname: Dieleman
authors.forename: P D
authors.initials: PD
authors.lastname: Siersema
authors.forename: M C J M
authors.initials: MC
authors.lastname: Sturkenboom
authors.forename: E J
authors.initials: EJ
authors.lastname: Kuipers
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology; D000328:Adult; D017677:Age Distribution; D001471:Barrett Esophagus / Q000453:epidemiology*; D016099:Endoscopy, Gastrointestinal; D004938:Esophageal Neoplasms / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D011159:Population Surveillance / Q000379:methods; D017678:Sex Distribution