title: [Perolen cream for therapy of rosacea].
abstract: Acne rosacea belongs to the most common inflammatory dermatoses of the face. Current treatments for this disease remain unsatisfactory, that's why searching for new methods and remedy are very important. For the topical therapy we have used a new cream perolen ("New Pharma", Georgia). The main component of the creme is the water extract of gastric mucous membrane of cow, which is the source of proteolytic ferments. Another main component is a Perilla oil which contains unsaturated fatty acids--linolenic and linol, presented in the highest amounts. The cream is characterized by bactericidal, bacteriostatical, anti-inflammatory and anti-oxidant effects, it also assists to tissue regeneration, make blood vessels more elastic and decreases penetration. We have observed 40 patients with papulo-pustular subtype of rosacea (25 females and 15 males). Patients were divided into two groups. For oral therapy in both groups we used Tetracycline and Trichopol. For topical treatment in the first group of patients was used rosamet cream and in the second group--perolen cream. Both of these creams were applied once daily during 2 months. Reduction of comedones, inflammations, papules, pustules and small nodules occurred after one month. Erythema, oedema, desquamation improved significantly during the treatment, but the positive effects were more prominent in the second group of patients. In conclusion, the study shows that topically used cream perelon represents a new approach in the management of acne rosacea.
authors.affiliation: Department of Dermatology and Venerology, Tbilisi State Medical University, Georgia.
authors.forename: L R
authors.initials: LR
authors.lastname: Beridze
authors.forename: L A
authors.initials: LA
authors.lastname: Mikaia
authors.forename: A Dzh
authors.initials: AD
authors.lastname: Bakuridze
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009824:Ointments; D010447:Peptide Hydrolases; D031343:Perilla; D010938:Plant Oils / Q000627:therapeutic use; D012393:Rosacea / Q000188:drug therapy*; D014020:Tissue Extracts / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D009824:Ointments; D010938:Plant Oils; D014020:Tissue Extracts; C504889:perolen; D010447:Peptide Hydrolases