title: A randomized, double-blind, multicenter study comparing a starting dose of 100 IU or 200 IU of recombinant follicle stimulating hormone (Puregon) in women undergoing controlled ovarian hyperstimulation for IVF treatment.
abstract: OBJECTIVE
  To compare the efficiency and efficacy of two starting doses of recombinant FSH (follitropin-beta, Puregon) in women undergoing IVF treatment.
  
  
  METHODS
  This prospective, randomized, double-blind, multicentric (N = 6) study included 192 women undergoing IVF using the long protocol of GnRH agonist who received either 100 IU or 200 IU of r-FSH per day. Gonadotropin dose adjustment was allowed after day 4 of stimulation.
  
  
  RESULTS
  The average (SD) number of oocytes retrieved was 10.9 (5.4) and 12.2 (5.6) in the 100 IU and 200 IU group respectively (p = 0.067). The total doses of Puregon administered were 1887 IU and 2559 IU in the 100 IU and 200 IU group respectively. The number of transferable embryos, and the rates of pregnancies, cancelled cycles, miscarriages and adverse events including OHSS were comparable between the two groups.
  
  
  CONCLUSIONS
  Women undergoing IVF have similar outcomes whether recombinant FSH is commenced in a dose of 100 IU or 200 IU for the first 4 days of stimulation.
authors.affiliation: Department of Obstetrics and Gynecology, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada. seanglin.tan@muhc.mcgill.ca
authors.forename: Seang Lin
authors.initials: SL
authors.lastname: Tan
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Child
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Cheung
authors.forename: Margo R
authors.initials: MR
authors.lastname: Fluker
authors.forename: Albert
authors.initials: A
authors.lastname: Yuzpe
authors.forename: Robert
authors.initials: R
authors.lastname: Casper
authors.forename: Peter
authors.initials: P
authors.lastname: Leung
authors.forename: Kenneth
authors.initials: K
authors.lastname: Cadesky
authors.forename: Victoria J
authors.initials: VJ
authors.lastname: Davis
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005307:Fertilization in Vitro; D043373:Follicle Stimulating Hormone, Human / Q000627:therapeutic use*; D006801:Humans; D009865:Oocytes; D010062:Ovulation Induction / Q000379:methods*; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D043373:Follicle Stimulating Hormone, Human