title: DTPA-bisamide-based MR sensor agents for peroxidase imaging.
abstract: [reaction: see text] The synthesis and some properties of two novel DTPA-bisamides are reported. These derivatives were designed as enzyme-activated contrast agents (CA) for magnetic resonance imaging. Both derivatives bear tyramido or 5-hydroxytryptamido groups that could be oligomerized in situ in the presence of peroxidase/H(2)O(2) pair resulting in a net increase in longitudinal (R1) relaxivity.
authors.affiliation: Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA.
authors.forename: Manuel
authors.initials: M
authors.lastname: Querol
authors.forename: John W
authors.initials: JW
authors.lastname: Chen
authors.forename: Ralph
authors.initials: R
authors.lastname: Weissleder
authors.forename: Alexei
authors.initials: A
authors.lastname: Bogdanov
mesh_terms: D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry; D019786:Gadolinium DTPA / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D004369:Pentetic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D010544:Peroxidases / Q000378:metabolism*
chemical_list: D003287:Contrast Media; D004369:Pentetic Acid; D010544:Peroxidases; D019786:Gadolinium DTPA