title: Histopathological study of small (<2 cm) gastric carcinoma with signet-ring cell component: significance of the admixed glandular components.
abstract: Admixture of signet-ring cell carcinoma component (SIG) and glandular component (GC) is sometimes found in a gastric cancer. The aim of this study was to elucidate the biological behavior of the gastric cancer containing either SIG only (SIG-type tumor) or SIG admixed with GC (SIG-GC-type tumor). Forty-three cases of SIG-type tumor and 26 cases of SIG-GC-type tumor, less than 2 cm in largest diameter, were examined. Twenty-six cases (60%) of SIGs were less than 10 mm in size, whereas only 3 cases (12%) of SIG-GCs were less than 10 mm in size (p<0.0001). Submucosal invasion by cancer cells was found in 12 cases of SIG-GCs but was not found in any of the SIGs. Those SIG-GCs showed gastric phenotype. It is important to note SIG-GC-type tumor for histopathological diagnosis.
authors.affiliation: Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ohkura
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kawamata
authors.forename: Yoko
authors.initials: Y
authors.lastname: Chibana
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Ichikawa
authors.forename: Sigehiko
authors.initials: S
authors.lastname: Fujii
authors.forename: Sigeru
authors.initials: S
authors.lastname: Tomita
authors.forename: Yuko
authors.initials: Y
authors.lastname: Ono
authors.forename: T
authors.initials: T
authors.lastname: Fujimori
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology; D014408:Biomarkers, Tumor / Q000378:metabolism; D018279:Carcinoma, Signet Ring Cell / Q000378:metabolism / Q000473:pathology*; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D009361:Neoplasm Invasiveness / Q000473:pathology; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor