title: Synthesis of enantiomerically pure cyclohex-2-en-1-ols: development of novel multicomponent reactions.
abstract: Multicomponent reactions of aldehydes, dienophiles, and alcohols or carboxylic acid anhydrides have been developed for the first time. In situ generation of 1-acyloxy- and 1-alkoxy-1,3-butadiene derivatives in toluene in the presence of electron-deficient dienophiles provides selective and efficient access to functionalized cyclohex-2-ene-1-ols in good yields. Subsequent enzyme-catalyzed kinetic resolution gave the corresponding enantiomers with high enantioselectivity.
authors.affiliation: Leibniz-Institut für Organische Katalyse an der Universität Rostock e.V. Buchbinderstr. 5-6, Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Strübing
authors.forename: Anett
authors.initials: A
authors.lastname: Kirschner
authors.forename: Helfried
authors.initials: H
authors.lastname: Neumann
authors.forename: Sandra
authors.initials: S
authors.lastname: Hübner
authors.forename: Stefan
authors.initials: S
authors.lastname: Klaus
authors.forename: Uwe T
authors.initials: UT
authors.lastname: Bornscheuer
authors.forename: Matthias
authors.initials: M
authors.lastname: Beller