title: Cyclopentane-modified PNA improves the sensitivity of nanoparticle-based scanometric DNA detection.
abstract: trans-Cyclopentane-modified PNA has been successfully utilized as a target capture strand to improve the detection limit of a known DNA detection assay, and provide high levels of mismatch discrimination.
authors.affiliation: Northwestern University and NIH, NIDDK, Laboratory of Bioorganic Chemistry, Bethesda, MD, USA.
authors.forename: Jonathan K
authors.initials: JK
authors.lastname: Pokorski
authors.forename: Jwa-Min
authors.initials: JM
authors.lastname: Nam
authors.forename: Rafael A
authors.initials: RA
authors.lastname: Vega
authors.forename: Chad A
authors.initials: CA
authors.lastname: Mirkin
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Appella
mesh_terms: D000942:Antigens, Bacterial / Q000235:genetics; D001427:Bacterial Toxins / Q000235:genetics; D020137:Base Pair Mismatch; D003517:Cyclopentanes / Q000737:chemistry*; D004247:DNA / Q000032:analysis* / Q000235:genetics; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D015345:Oligonucleotide Probes; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D012680:Sensitivity and Specificity
chemical_list: D000942:Antigens, Bacterial; D001427:Bacterial Toxins; D003517:Cyclopentanes; D015345:Oligonucleotide Probes; D020135:Peptide Nucleic Acids; C030325:anthrax toxin; D004247:DNA