title: Impact of local guidelines and an integrated dispensing system on antibiotic prophylaxis quality in a surgical centre.
abstract: Surgical antibiotic prophylaxis is effective in preventing postoperative wound infections. Guidelines are designed to optimize antimicrobial use in this setting. The aim of this study was to assess antibiotic use in surgical prophylaxis in a surgical hospital before and after the implementation of both local antibiotic prophylaxis guidelines and a specific medication set for various surgical procedures. The appropriateness of surgical antibiotic prophylaxis increased from 50.9% in the pre-implementation stage to 94.9% in the postimplementation stage (P<0.001). The implementation of a multidisciplinary protocol and design of medication sets helped to improve the practice of surgical antibiotic prophylaxis.
authors.affiliation: Pharmacy Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain. calerany@vhebron.net
authors.forename: C
authors.initials: C
authors.lastname: Alerany
authors.forename: D
authors.initials: D
authors.lastname: Campany
authors.forename: J
authors.initials: J
authors.lastname: Monterde
authors.forename: C
authors.initials: C
authors.lastname: Semeraro
mesh_terms: D019072:Antibiotic Prophylaxis / Q000379:methods / Q000592:standards; D016009:Chi-Square Distribution; D002985:Clinical Protocols / Q000592:standards; D019033:Delivery of Health Care, Integrated / Q000458:organization & administration; D004334:Drug Administration Schedule; D004363:Drug Utilization; D005260:Female; D019983:Guideline Adherence / Q000592:standards*; D006785:Hospitals, University; D006801:Humans; D017053:Infection Control / Q000458:organization & administration*; D008297:Male; D008510:Medication Systems, Hospital / Q000458:organization & administration*; D008875:Middle Aged; D010348:Patient Care Team / Q000458:organization & administration; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians' / Q000458:organization & administration; D011367:Professional Staff Committees / Q000458:organization & administration; D019984:Quality Indicators, Health Care; D013030:Spain; D013514:Surgical Procedures, Operative / Q000009:adverse effects / Q000706:statistics & numerical data; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D013997:Time Factors