[Effect of weight loss induced by laparoscopic adjustable gastric banding on immunity of morbid obesity].
OBJECTIVE
To compare the immunity of morbid obesity (MO) before and after laparoscopic adjustable gastric banding (LAGB).


METHODS
15 cases, with a mean body mass index (BMI) of 35.8 kg/m(2), were treated by LAGB from Jun. 2003 to Oct. 2003 in our department. Patients' immune parameters were determined preoperatively and 1, 3 and 6 months postoperatively. 15 cases with a normal BMI (23.6 kg/m(2)) were set as controls.


RESULTS
Before surgery, the MO had a significant lower level of CD(4)(+), CD(4)(+)/CD(8)(+) and a higher level of serum interleukin-2 (IL-2), Interleukin-6 (IL-6) than the controls (P < 0.01). There was a significant reduction of weight and BMI 6 months postoperatively (P < 0.01). At the same time, CD(4)(+) increased and serum IL-2 decreased significantly. But CD(4)(+)/CD(8)(+)and serum IL-2, IL-6 were still abnormal compare to the controls.


CONCLUSIONS
MO may combined with an abnormal immunity. But after enough weight loss induced by LAGB, it can be partly reversed.
Hu
Ming-gen
MG
Department of Microinvasive Surgery, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China. hmg780305@sina.com.cn
Zheng
Cheng-zhu
CZ
Ke
Chong-wei
CW
Yin
Kai
K
Li
Ji-hui
JH
Hu
Bin
B
Wu
Yue-feng
YF
Cao
Ping
P
Zou
Da-jin
DJ
Zhang
Jun
J
D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D015391:Gastroplasty / Q000379:methods*; D006801:Humans; D010535:Laparoscopy; D008297:Male; D009767:Obesity, Morbid / Q000276:immunology / Q000601:surgery*; D015431:Weight Loss