title: Combined effects of pulsatile flow and dynamic curvature on wall shear stress in a coronary artery bifurcation model.
abstract: A three-dimensional model with simplified geometry for the branched coronary artery is presented. The bifurcation is defined by an analytical intersection of two cylindrical tubes lying on a sphere that represents an idealized heart surface. The model takes into account the repetitive variation of curvature and motion to which the vessel is subject during each cardiac cycle, and also includes the phase difference between arterial motion and blood flowrate, which may be nonzero for patients with pathologies such as aortic regurgitation. An arbitrary Lagrangian Eulerian (ALE) formulation of the unsteady, incompressible, three-dimensional Navier-Stokes equations is employed to solve for the flow field, and numerical simulations are performed using the spectral/hp element method. The results indicate that the combined effect of pulsatile inflow and dynamic geometry depends strongly on the aforementioned phase difference. Specifically, the main findings of this work show that the time-variation of flowrate ratio between the two branches is minimal (less than 5%) for the simulation with phase difference angle equal to 90 degrees, and maximal (51%) for 270 degrees. In two flow pulsatile simulation cases for fixed geometry and dynamic geometry with phase angle 270 degrees, there is a local minimum of the normalized wall shear rate amplitude in the vicinity of the bifurcation, while in other simulations a local maximum is observed.
authors.affiliation: Division of Applied Mathematics, Center for Fluid Mechanics, 182 George Street, Box F, Providence, RI 02912, USA.
authors.forename: I V
authors.initials: IV
authors.lastname: Pivkin
authors.forename: P D
authors.initials: PD
authors.lastname: Richardson
authors.forename: D H
authors.initials: DH
authors.lastname: Laidlaw
authors.forename: G E
authors.initials: GE
authors.lastname: Karniadakis
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D003198:Computer Simulation; D003331:Coronary Vessels / Q000033:anatomy & histology* / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D011673:Pulsatile Flow / Q000502:physiology*; D033081:Shear Strength