title: Synthetic studies toward the construction of the cis-decalin portion of superstolides A and B. Application of a sequential double michael reaction and an anionic oxy-Cope rearrangement.
abstract: A highly convergent strategy for the asymmetric synthesis of the cis-decalin portion of the antitumor macrolide superstolide A was developed. The key reactions in our approach involve a sequential double Michael reaction and an anionic oxy-Cope rearrangement.
authors.affiliation: Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, 52242, USA.
authors.forename: Zhengmao
authors.initials: Z
authors.lastname: Hua
authors.forename: Wensheng
authors.initials: W
authors.lastname: Yu
authors.forename: Mei
authors.initials: M
authors.lastname: Su
authors.forename: Zhendong
authors.initials: Z
authors.lastname: Jin
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002175:Candida / Q000201:enzymology; D006868:Hydrolysis; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry; D013237:Stereoisomerism; D013764:Tetrahydronaphthalenes / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D018942:Macrolides; D013764:Tetrahydronaphthalenes; C091984:superstolide A; C091985:superstolide B