Synthesis of novel polycyclic indolyldiamines.
A rapid and stereoselective access to novel polycyclic indolyldiamines is described. The key step involves simple chemoselective transformations of a common bicyclic aminal intermediate, easily available on a large scale from an enantiomerically pure cyano oxazolopiperidine precursor.
Cutri
Sabrina
S
Laboratoire de Chimie Thérapeutique, Faculté des Sciences Pharmaceutiques et Biologiques, UMR 8638 associée au CNRS et à l'Université René Descartes, Paris.
Diez
Anna
A
Bonin
Martine
M
Micouin
Laurent
L
Husson
Henri-Philippe
HP