Developmental expression patterns and localization of DNA-binding protein inhibitor (Id3) in the mouse retina.
Id3 (inhibitor of DNA binding/differentiation), a member of the Id helix-loop-helix protein family, has long been studied as a positive regulator of proliferation and a negative regulator of differentiation. In this study, we examined the expression pattern and cellular phenotypes of Id3 in postnatal and adult mouse retina. Id3 was mainly expressed in the early postnatal inner retina. From the late postnatal development towards adulthood, Id3 expression was confined to the ganglion cell layer and the inner nuclear layer. Colocalization analysis showed that Id3 positive cells were identified as retinal ganglion cells and amacrine cells. The differential expression profiles of Id3 provide the groundwork for the elucidation of its possible role in retinal development.
Yeung
S C
SC
Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong.
Yip
H K
HK
D000367:Age Factors; D025042:Amacrine Cells / Q000166:cytology / Q000378:metabolism; D000818:Animals; D002455:Cell Division / Q000502:physiology; D005260:Female; D007150:Immunohistochemistry; D051796:Inhibitor of Differentiation Proteins; D051379:Mice; D008807:Mice, Inbred BALB C; D011247:Pregnancy; D011506:Proteins / Q000378:metabolism*; D012160:Retina / Q000166:cytology / Q000196:embryology* / Q000378:metabolism*; D012165:Retinal Ganglion Cells / Q000166:cytology / Q000378:metabolism
D051796:Inhibitor of Differentiation Proteins; D011506:Proteins; C067679:Idb3 protein, mouse