[Manifestations mimicking relapsing polychondritis in a patient with microscopic polyangiitis].
Microscopic polyangiitis (MPA) is a systemic disorder characterized by inflammation of small vessels mainly affecting the kidneys and lungs. We describe a 72-year-old woman who developed multiple cartilage involvements as well as major manifestations of MPA. The left ear biopsy demonstrated cartilaginous inflammation and small vessel vasculitis. She also had conjunctivitis, hearing impairment, interstitial lung disease, glomerulonephritis with vasculitis and mononeuritis multiplex. Serological examinations revealed a positive antineutrophil cytoplasmic antibody (PR-3 ANCA). Cyclophosphamide and oral corticosteroid therapy was instituted and remission achieved. Due to lacks of nasal and bronchial involvements, as well as the evidence of auricular vasculitis, we concluded that her findings mimicking relapsing polychondritis developed as systemic manifestations of MPA.
Ogawa
Hiroe
H
The Second Department of Internal Medicine, Saitama Medical Center.
Nishi
Eiko
E
Kameda
Hideto
H
Amano
Koichi
K
Takeuchi
Tsutomu
T
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis; D003520:Cyclophosphamide / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D011081:Polychondritis, Relapsing / Q000209:etiology* / Q000473:pathology; D011239:Prednisolone / Q000008:administration & dosage; D014657:Vasculitis / Q000150:complications* / Q000175:diagnosis / Q000473:pathology
D000893:Anti-Inflammatory Agents; D019268:Antibodies, Antineutrophil Cytoplasmic; D003520:Cyclophosphamide; D011239:Prednisolone