A novel HLA-B*55 allele, HLA-B*5514, found in a DNA sample derived from a bone marrow donor.
In this study, we report the identification of a new human leucocyte antigen-B (HLA-B) allele in a sample that was found in our routine typing. This novel allele, officially designed HLA-B*5514, was found in a male donor of Bavarian Caucasoid origin (Laboratory code: 117562) typed in order for a request of the bone marrow donor registry Aktion Knochenmarkspende Bayern. Although this novel allele was added to the HLA-B*55 family by the Nomenclature Committee, the next related alleles were found in the HLA-B*56 group; HLA-B*5612 differing in six positions from HLA-B*5514 is the closest related allele.
Witter
K
K
Laboratory of Immunogenetics, University Munich, Paul-Heyse-Strasse 33, 80336 Munich, Germany. kwitter@kk-i.med.uni-muenchen.de
Zahn
R
R
McNicholas
A
A
Volgger
A
A
Albert
E D
ED
D000328:Adult; D000483:Alleles; D001483:Base Sequence; D016026:Bone Marrow Transplantation; D005805:Genes, MHC Class I; D005858:Germany; D015235:HLA-B Antigens / Q000737:chemistry / Q000235:genetics* / Q000302:isolation & purification; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D014019:Tissue Donors
D015235:HLA-B Antigens; C503739:HLA-B*55:14 antigen