title: Area under the curve for estradiol levels do not consistently reflect estradiol levels on the day of hCG administration in patients undergoing controlled ovarian hyperstimulation for IVF-ET.
abstract: OBJECTIVE
  Most studies reported estradiol (E2) levels attained on day of hCG administration when investigating effect of E2 on IVF outcome. We studied whether a relationship exists between the area under the curve for E2 levels (AUC-E2) and E2 levels on hCG day during IVF-ET.
  
  
  METHODS
  Retrospectively, we analyzed data for 313 patients who completed one IVF-ET cycle each. Patients were sorted according to AUC-E2 levels. Then we compared between each patient's own AUC-E2 and the corresponding E2 level on hCG day for the same patient.
  
  
  RESULTS
  Although overall AUC-E2 correlated positively with E2 levels on hCG day, there was no consistent correlation between individual patients.
  
  
  CONCLUSIONS
  AUC-E2 reflects more accurately the amount of E2 produced by the follicles during controlled ovarian hyperstimulation. The absence of a uniform correlation between AUC-E2 and E2 on hCG day may result in different conclusions when studying outcomes of IVF treatment.
authors.affiliation: Department of Gynecology and Obstetrics, School of Medicine and Health Sciences, University at Buffalo, State University of New York (SUNY), 219 Bryant Street, Buffalo, New York 14222, USA.
authors.forename: Mohamed F M
authors.initials: MF
authors.lastname: Mitwally
authors.forename: Hemlata S
authors.initials: HS
authors.lastname: Bhakoo
authors.forename: Kent
authors.initials: K
authors.lastname: Crickard
authors.forename: Michael W
authors.initials: MW
authors.lastname: Sullivan
authors.forename: Ronald E
authors.initials: RE
authors.lastname: Batt
authors.forename: John
authors.initials: J
authors.lastname: Yehl
mesh_terms: D019540:Area Under Curve; D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000627:therapeutic use; D004624:Embryo Transfer; D004958:Estradiol / Q000097:blood* / Q000493:pharmacokinetics*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D006080:Ovarian Follicle / Q000187:drug effects / Q000502:physiology; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013997:Time Factors
chemical_list: D006063:Chorionic Gonadotropin; D004958:Estradiol