Tuberous and tendinous xanthomata secondary to ritonavir-associated hyperlipidemia.
Xanthomas most often occur in conjunction with a primary or secondary disorder of lipid metabolism. A range of metabolic disturbances has been described in association with protease inhibitors, including lipodystrophy, hyperglycemia, and hyperlipidemia. Ritonavir has been repeatedly shown to be the most common protease inhibitor to induce these metabolic abnormalities. This report highlights a case of both tuberous and tendinous xanthomata secondary to ritonavir-associated hyperlipidemia.
Brown
Chad A
CA
Section of Dermatology, Department of Medicine, Medical College of Georgia, Augusta 30912, USA.
Lesher
Jack L
JL
Peterson
Christopher M
CM
D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000009:adverse effects*; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D006949:Hyperlipidemias / Q000139:chemically induced* / Q000150:complications*; D008297:Male; D008875:Middle Aged; D019438:Ritonavir / Q000009:adverse effects*; D012867:Skin / Q000473:pathology; D013710:Tendons / Q000473:pathology; D014973:Xanthomatosis / Q000209:etiology* / Q000473:pathology
D017320:HIV Protease Inhibitors; D019438:Ritonavir