title: [Sildenafil for pulmonary hypertension treatment after cardiac surgery].
abstract: OBJECTIVE
  To report on the use of sildenafil for pulmonary hypertension treatment of a newborn patient after cardiac surgery.
  
  
  METHODS
  A female, full term newborn infant with diagnosis of double outlet right ventricle, pulmonary hypoplasia and subaortic ventricular septal defect, was submitted to Blalock surgery in the first week of life. In postoperative the newborn had pulmonary hypertension and persistent hypoxia, without response to nitric oxide, but with improved oxygenation after continuous intravenous infusion of prostaglandin E1. After several failed attempts to discontinue prostaglandin E1, oral sildenafil was used. There was a decrease in pulmonary vascular resistance with consequent oxygenation improvement and 48 hours later it was possible to discontinue prostaglandin E1 infusion.
  
  
  CONCLUSIONS
  Sildenafil can be an alternative therapy for pulmonary hypertension, especially when there is no response to conventional therapy.
authors.affiliation: Departamento de Pediatria, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP. mbentlin@fmb.unesp.br
authors.forename: Maria Regina
authors.initials: MR
authors.lastname: Bentlin
authors.forename: Adriana
authors.initials: A
authors.lastname: Saito
authors.forename: Ana Karina C
authors.initials: AK
authors.lastname: De Luca
authors.forename: Grasiela
authors.initials: G
authors.lastname: Bossolan
authors.forename: Rossano C
authors.initials: RC
authors.lastname: Bonatto
authors.forename: Antonio S
authors.initials: AS
authors.lastname: Martins
authors.forename: Lígia M S S
authors.initials: LM
authors.lastname: Rugolo
mesh_terms: D006348:Cardiac Surgical Procedures; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy*; D007231:Infant, Newborn; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D010879:Piperazines / Q000627:therapeutic use*; D011184:Postoperative Period; D011687:Purines; D000068677:Sildenafil Citrate; D013450:Sulfones
chemical_list: D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate