Quantification of adenovirus in the lower respiratory tract of patients without clinical adenovirus-related respiratory disease.
Adenovirus in bronchoalveolar lavage fluid samples from 50 patients without adenovirus-related illness was quantified. In 49 patients, adenovirus was found (median load, 3.3 x 10(3) copies/microg of DNA). The adenovirus load was inversely related to lymphocyte count (Pearson correlation coefficient r = -0.311; P = .03) and was significantly greater in immunosuppressed patients than in immunocompetent patients (5.1 x 10(3) vs. 2.0 x 10(3) copies/microg of DNA; P = .028).
Leung
Anskar Yu-Hung
AY
Department of Medicine, University of Hong Kong, Hong Kong.
Chan
Maggie
M
Cheng
Vincent Chi-Chung
VC
Yuen
Kwok-Yung
KY
Kwong
Yok-Lam
YL
D000260:Adenoviruses, Human / Q000302:isolation & purification*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001992:Bronchoalveolar Lavage Fluid / Q000821:virology; D002353:Carrier State / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D007121:Immunocompetence; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D012137:Respiratory System / Q000821:virology*; D019562:Viral Load
D004279:DNA, Viral