Pediatric meningosarcoma: clinical evolution and genetic instability.
This report presents a female diagnosed with a frontoparietal interhemispheric meningosarcoma who, parallel to the clinical worsening, revealed an increase in the genetic instability (in bleomycin cultures) and the complexity of the karyotypes, with the acquisition of a clonal deletion of 17p13 (the locus for the TP53 tumor suppressor gene). The genetic findings of this patient suggest that the increased genetic instability could contribute to tumor progression as well as to treatment resistance, possibly in the background of the clonal deletion of TP53.
de Mesa
Reyes López
RL
Laboratory and Department of Pediatrics, University Clinic and University of Navarra, Pamplona, Spain.
Sierrasesúmaga
Luis
L
de Cerain
Adela López
AL
Calasanz
María José
MJ
Patiño-García
Ana
A
D002648:Child; D018450:Disease Progression; D005260:Female; D017353:Gene Deletion; D006801:Humans; D007621:Karyotyping; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000235:genetics* / Q000473:pathology*; D008579:Meningioma / Q000235:genetics* / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D016159:Tumor Suppressor Protein p53