title: [The addiction of ephedrine like psychostimulators and use of nimotop for its correction].
abstract: Twenty six patients, used home-made ephedrine like psychostimulators were examined. Nervous system pathology in these cases was characterized by short (several months) period of the pathological process formation, young patient's age, absence of family psychiatric history, pronounced systemic and multilevel affection of the organism, severity of psychic defects and patients disability. Electrophysiological study revealed essential changes of neurodynamics manifesting with insufficiency of non-specific activating brain system, diencephalic stem structure dysfunction, deep structure irritation that might correspond to clinical picture of multisystem CNS lesions. An involvement of limbic reticular structures in pathological process on the background of neurophysiological immaturity was detected as well. In patients disorders of brain homeostatic mechanisms and cognitive functions were also found. Deprivation of reactivity of upper-segmental autonomic system regulation can determine rigidity and pathological adaptation of such patients. Insufficiency of activating systems of reticular formation, arrhythmia, disturbances of cognitive functions and cerebral homeostasis dictate a need for nootropics prescription for these patients. Clinical experience justifies including drug nimotop in complex treatment and rehabilitation schemes.
authors.forename: N P
authors.initials: NP
authors.lastname: Voloshina
authors.forename: I L
authors.initials: IL
authors.lastname: Levchenko
authors.forename: I V
authors.initials: IV
authors.lastname: Volganova
mesh_terms: D000328:Adult; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D000697:Central Nervous System Stimulants / Q000009:adverse effects; D004562:Electrocardiography; D004569:Electroencephalography; D004809:Ephedrine / Q000009:adverse effects; D006801:Humans; D009553:Nimodipine / Q000627:therapeutic use*; D019966:Substance-Related Disorders / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology / Q000534:rehabilitation
chemical_list: D002121:Calcium Channel Blockers; D000697:Central Nervous System Stimulants; D009553:Nimodipine; D004809:Ephedrine