The immunohistochemical profile of luminal epithelial neoplastic component from pleomorphic adenomas of salivary glands.
The immunohistochemistry study made on 30 cases of salivary glands pleomorphic adenomas aims to establish the antigen profile of luminal epithelial neoplastic component proliferates into these tumors. We ascertain that luminal epithelial neoplastic cell were almost exclusively positive to antibody peculiar to epithelial differentiation (AE1/AE3, MNF 116, CK 8, CK 19, CK20, EMA) and occasional to S-100 protein and negative to vimentin, alpha-smooth muscle actin, calponin, Glial Fibrillary Acidic Protein (GFAP). This kind of immunoreactivity was similar to ductal cells from striated channels of salivary glands, suggesting the origin of such pleomorphic adenomas from this place.
Margaritescu
C
C
Department of Pathology, Faculty of Dentistry, University of Medicine and Pharmacy of Craiova, Dolj. mclaudiu@umfcv.ro
Florescu
M
M
Raica
M
M
Simionescu
C
C
Mogoanta
L
L
Preda
E
E
D008949:Adenoma, Pleomorphic / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002454:Cell Differentiation; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009418:S100 Proteins / Q000378:metabolism; D012468:Salivary Gland Neoplasms / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology*
D014408:Biomarkers, Tumor; D009418:S100 Proteins