title: Application of surface ionization methods for highly sensitive and selective analysis of benzodiazepine derivatives.
abstract: In this work, the results of studying the possibilities of surface ionization mass spectrometry (SI/MS) and atmosphere pressure thermodesorption surface ionization (APTDSI) spectroscopy for high-sensitivity and selective detection and identification of psychotropic preparations of benzodiazepine derivatives--medazepam, diazepam and chlordiazepoxide--are presented. It has been established that the SI mass spectra of benzodiazepines have a small number of lines and are significantly different from those obtained by electron ionization (EI) and that the molecules of benzodiazepines can be ionized by surface ionization with high efficiency (> or = 100 times and more than by EI) and the current density increases from diazepam to medazepam. It has been found that the APTDSI spectra of benzodiazepine derivatives have two characteristic maxima connected with energy of sublimation and desorption. The ionization efficiency is several C/g (Coulomb per gram), the linear range of the concentration dependence is 3-4 orders of a magnitude. The results obtained by the SI/MS and APTDSI methods have been compared with those obtained by the conventional TLC and GC/MS with electron ionization.
authors.affiliation: Arifov Institute of Electronics, Akademgorodok, 700125 Tashkent, Uzbekistan. ariel@ariel.uzsci.net
authors.forename: Usman
authors.initials: U
authors.lastname: Khasanov
authors.forename: Utkur
authors.initials: U
authors.lastname: Rasulev
authors.forename: Dilshod
authors.initials: D
authors.lastname: Usmanov
authors.forename: Saida
authors.initials: S
authors.lastname: Iskhakova
authors.forename: Ulugbek
authors.initials: U
authors.lastname: Nabiev
mesh_terms: D001569:Benzodiazepines / Q000032:analysis* / Q000737:chemistry*; D018629:Spectrometry, Mass, Secondary Ion / Q000379:methods*; D013499:Surface Properties
chemical_list: D001569:Benzodiazepines