title: A synthetic route to a novel type of conformationally constrained N-aryloxazolidinones.
abstract: The synthesis of N-aryloxazolidinone 1, a conformationally constrained analog of linezolid embodying a tricyclic pyrrolo[1,2-a][4,1]benzoxazepine moiety as the N-aryl substituent, is reported. The synthetic route involves the successive construction of the pyrrole, oxazepine, and oxazolidinone rings, with incorporation of the isoxazolylamino moiety in the last synthetic steps.
authors.affiliation: Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, 0802-Barcelona, Spain.
authors.forename: Rosa
authors.initials: R
authors.lastname: Griera
authors.forename: Carme
authors.initials: C
authors.lastname: Cantos-Llopart
authors.forename: Mercedes
authors.initials: M
authors.lastname: Amat
authors.forename: Joan
authors.initials: J
authors.lastname: Bosch
authors.forename: Juan-C
authors.initials: JC
authors.lastname: del Castillo
authors.forename: Joan
authors.initials: J
authors.lastname: Huguet
mesh_terms: D008968:Molecular Conformation; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D023303:Oxazolidinones