[The pharmacokinetic effect of haloperidol on DA receptors].
There is increasing evidence that the metabolism of haloperidol is of major significance in the action of the drug. The metabolism of haloperidol is quite simple. It keeps only typical oxidative metabolic pathway. Despite of the existing knowledge of such pathways we still do not know the exact fate of the administered compound in the serum and urine. The aim of the study was the investigation of the influence of haloperidol and its oxidative forms on D(A) and its compounds in serum. The 12,0 hour investigation demonstrated a protective effect on D(A) activity. The D(A) synthesis rate constant was increased to about the same level by GBL as well as by haloperidol. Therefore, the differences between the two regions in the reactions to the drugs to a large extent could be explained by a high and low synthesis of D(A), under controlled conditions in the olfactory tubercle and the corpus striatum.
Giorgobiani
I B
IB
Research Institute of Psychiatry, Tbilisi, Georgia.
Kitiashvili
S A
SA
D000818:Animals; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D015306:Biogenic Monoamines / Q000378:metabolism*; D001682:Biological Availability; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D004285:Dogs; D006220:Haloperidol / Q000008:administration & dosage / Q000494:pharmacology*; D007273:Injections, Intramuscular; D011954:Receptors, Dopamine / Q000187:drug effects*
D014150:Antipsychotic Agents; D015306:Biogenic Monoamines; D011954:Receptors, Dopamine; D006220:Haloperidol