Actin polymerization machinery: the finish line of signaling networks, the starting point of cellular movement.
Dynamic assembly of actin filaments generates the forces supporting cell motility. Several recent biochemical and genetic studies have revealed a plethora of different actin binding proteins whose coordinated activity regulates the turnover of actin filaments, thus controlling a variety of actin-based processes, including cell migration. Additionally, emerging evidence is highlighting a scenario whereby the same basic set of actin regulatory proteins is also the convergent node of different signaling pathways emanating from extracellular stimuli, like those from receptor tyrosine kinases. Here, we will focus on the molecular mechanisms of how the machinery of actin polymerization functions and is regulated, in a signaling-dependent mode, to generate site-directed actin assembly leading to cell motility.
Disanza
A
A
IFOM, Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20134, Milan, Italy.
Steffen
A
A
Hertzog
M
M
Frittoli
E
E
Rottner
K
K
Scita
G
G
D008841:Actin Cytoskeleton / Q000378:metabolism / Q000502:physiology*; D000199:Actins / Q000378:metabolism; D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000502:physiology; D006801:Humans; D008840:Microfilament Proteins / Q000502:physiology; D008954:Models, Biological; D011554:Pseudopodia / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D020744:rac GTP-Binding Proteins / Q000502:physiology; D020741:rho GTP-Binding Proteins / Q000502:physiology
D000199:Actins; D003598:Cytoskeletal Proteins; D008840:Microfilament Proteins; D020744:rac GTP-Binding Proteins; D020741:rho GTP-Binding Proteins