Axon regeneration: it's getting crowded at the gates of TROY.
A novel neuronal receptor complex that mediates myelin's inhibitory action on nerve fiber regeneration has at last been identified. This discovery could be an important step towards promoting nerve regeneration after stroke or spinal cord injury.
Mandemakers
Wim J
WJ
Stanford University School of Medicine, Neurobiology Department, Sherman Fairchild Science Building, California 94305, USA. mandemak@stanford.edu
Barres
Ben A
BA
D000818:Animals; D001369:Axons / Q000502:physiology*; D002490:Central Nervous System / Q000502:physiology*; D058851:GPI-Linked Proteins; D005727:Ganglia, Spinal / Q000378:metabolism; D008565:Membrane Proteins; D008958:Models, Molecular; D046912:Multiprotein Complexes / Q000378:metabolism*; D009185:Myelin Proteins / Q000378:metabolism; D018992:Myelin-Associated Glycoprotein / Q000378:metabolism; D009416:Nerve Regeneration / Q000502:physiology*; D009419:Nerve Tissue Proteins; D016501:Neurites / Q000378:metabolism; D000070816:Nogo Receptor 1; D020800:Receptor, Nerve Growth Factor; D011956:Receptors, Cell Surface / Q000378:metabolism; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D020742:rhoA GTP-Binding Protein / Q000378:metabolism
D058851:GPI-Linked Proteins; C482293:LINGO1 protein, human; D008565:Membrane Proteins; D046912:Multiprotein Complexes; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D009419:Nerve Tissue Proteins; D000070816:Nogo Receptor 1; C486580:RTN4R protein, human; D020800:Receptor, Nerve Growth Factor; D011956:Receptors, Cell Surface; D017475:Receptors, Nerve Growth Factor; D018124:Receptors, Tumor Necrosis Factor; C411850:TNFRSF19 protein, human; D020742:rhoA GTP-Binding Protein