Oral immunization of sows: anti-K88 antibodies in serum and milk of the sow and in serum of the piglets.
Pregnant sows were immunized by oral application of live E. coli. The effect of immunization was demonstrated by measuring the titers of anti-K88 antibodies in sow serum, colostrum and milk as well as in piglet sera using enzyme-linked immunosorbent assays. The isotype involved in anti-K88 reactivity was found to be IgA. By comparing IgA-titers in colostrum and milk, the local production of this Ig-class in the mammary gland is suggested.
Kortbeek-Jacobs
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Departments of Immunology resp Bacteriology, Faculty of Veterinary Medicine, State University Utrecht, the Netherlands.
van Houten
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D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn; D000907:Antibodies, Bacterial / Q000096:biosynthesis* / Q000097:blood; D000942:Antigens, Bacterial / Q000276:immunology*; D003126:Colostrum / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D004926:Escherichia coli / Q000276:immunology*; D004927:Escherichia coli Infections / Q000517:prevention & control / Q000662:veterinary; D029968:Escherichia coli Proteins / Q000276:immunology*; D005260:Female; D036781:Fimbriae Proteins / Q000276:immunology*; D007070:Immunoglobulin A / Q000096:biosynthesis* / Q000097:blood; D008892:Milk / Q000276:immunology; D011247:Pregnancy; D013552:Swine / Q000097:blood / Q000276:immunology*; D013553:Swine Diseases / Q000517:prevention & control; D014611:Vaccination / Q000662:veterinary*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D029968:Escherichia coli Proteins; D007070:Immunoglobulin A; C026888:K88 antigen, E coli; D036781:Fimbriae Proteins