title: Response to a urate-lowering diet according to polymorphisms in the apolipoprotein AI-CIII-AIV cluster.
abstract: OBJECTIVE
  The apolipoprotein AI-CIII-AIV cluster has been associated with the response to a urate-lowering diet, and polymorphisms in the apolipoprotein CIII gene have been associated with hyperuricemia and hypertriglyceridemia. We assessed the influence of polymorphisms in the apolipoprotein AI-CIII-AIV cluster on the response to a urate-lowering diet in patients with hyperuricemia.
  
  
  METHODS
  A urate-lowering diet was followed for 2 weeks by 64 men with hyperuricemia. Plasma concentrations of triglycerides, cholesterol, glucose, and uric acid, and the uric acid clearance and 24-hour uric acid urinary excretory fraction were measured before and after the diet. The data were analyzed in association with the polymorphisms of the apolipoprotein AI-CIII-AIV gene cluster.
  
  
  RESULTS
  After the urate-lowering diet, the plasma levels of triglycerides, cholesterol, glucose, and uric acid and 24-hour uric acid excretion all fell significantly. Paired sample ANOVA showed that the decrease was mainly due to the diet, except for the plasma triglycerides, which were influenced by allele X2 of the XmnI polymorphism of the apolipoprotein AI gene.
  
  
  CONCLUSIONS
  The response of the biological variables to a urate-lowering diet was mainly influenced by diet. Changes in triglycerides were also influenced by the apolipoprotein AI XmnI polymorphism (p = 0.04), suggesting a gene-diet interaction (p = 0.03).
authors.affiliation: Endocrinology and Nutrition Service, Hospital Civil, Carlos Haya University Hospital, Málaga, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Cardona
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Tinahones
authors.forename: Eduardo
authors.initials: E
authors.lastname: Collantes
authors.forename: Eduardo
authors.initials: E
authors.lastname: Garcia-Fuentes
authors.forename: Alejandro
authors.initials: A
authors.lastname: Escudero
authors.forename: Federico
authors.initials: F
authors.lastname: Soriguer
mesh_terms: D016632:Apolipoprotein A-I / Q000235:genetics*; D053305:Apolipoprotein C-III; D001054:Apolipoproteins A / Q000235:genetics; D001056:Apolipoproteins C / Q000235:genetics; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000178:diet therapy* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D005810:Multigene Family; D011110:Polymorphism, Genetic; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood*
chemical_list: D016632:Apolipoprotein A-I; D053305:Apolipoprotein C-III; D001054:Apolipoproteins A; D001056:Apolipoproteins C; D014280:Triglycerides; C022205:apolipoprotein A-IV; D014527:Uric Acid