title: The genome sequence of the rice blast fungus Magnaporthe grisea.
abstract: Magnaporthe grisea is the most destructive pathogen of rice worldwide and the principal model organism for elucidating the molecular basis of fungal disease of plants. Here, we report the draft sequence of the M. grisea genome. Analysis of the gene set provides an insight into the adaptations required by a fungus to cause disease. The genome encodes a large and diverse set of secreted proteins, including those defined by unusual carbohydrate-binding domains. This fungus also possesses an expanded family of G-protein-coupled receptors, several new virulence-associated genes and large suites of enzymes involved in secondary metabolism. Consistent with a role in fungal pathogenesis, the expression of several of these genes is upregulated during the early stages of infection-related development. The M. grisea genome has been subject to invasion and proliferation of active transposable elements, reflecting the clonal nature of this fungus imposed by widespread rice cultivation.
authors.affiliation: Center for Integrated Fungal Research, North Carolina State University, Raleigh, North Carolina 27695, USA. Ralph_Dean@ncsu.edu
authors.forename: Ralph A
authors.initials: RA
authors.lastname: Dean
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Talbot
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Ebbole
authors.forename: Mark L
authors.initials: ML
authors.lastname: Farman
authors.forename: Thomas K
authors.initials: TK
authors.lastname: Mitchell
authors.forename: Marc J
authors.initials: MJ
authors.lastname: Orbach
authors.forename: Michael
authors.initials: M
authors.lastname: Thon
authors.forename: Resham
authors.initials: R
authors.lastname: Kulkarni
authors.forename: Jin-Rong
authors.initials: JR
authors.lastname: Xu
authors.forename: Huaqin
authors.initials: H
authors.lastname: Pan
authors.forename: Nick D
authors.initials: ND
authors.lastname: Read
authors.forename: Yong-Hwan
authors.initials: YH
authors.lastname: Lee
authors.forename: Ignazio
authors.initials: I
authors.lastname: Carbone
authors.forename: Doug
authors.initials: D
authors.lastname: Brown
authors.forename: Yeon Yee
authors.initials: YY
authors.lastname: Oh
authors.forename: Nicole
authors.initials: N
authors.lastname: Donofrio
authors.forename: Jun Seop
authors.initials: JS
authors.lastname: Jeong
authors.forename: Darren M
authors.initials: DM
authors.lastname: Soanes
authors.forename: Slavica
authors.initials: S
authors.lastname: Djonovic
authors.forename: Elena
authors.initials: E
authors.lastname: Kolomiets
authors.forename: Cathryn
authors.initials: C
authors.lastname: Rehmeyer
authors.forename: Weixi
authors.initials: W
authors.lastname: Li
authors.forename: Michael
authors.initials: M
authors.lastname: Harding
authors.forename: Soonok
authors.initials: S
authors.lastname: Kim
authors.forename: Marc-Henri
authors.initials: MH
authors.lastname: Lebrun
authors.forename: Heidi
authors.initials: H
authors.lastname: Bohnert
authors.forename: Sean
authors.initials: S
authors.lastname: Coughlan
authors.forename: Jonathan
authors.initials: J
authors.lastname: Butler
authors.forename: Sarah
authors.initials: S
authors.lastname: Calvo
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Ma
authors.forename: Robert
authors.initials: R
authors.lastname: Nicol
authors.forename: Seth
authors.initials: S
authors.lastname: Purcell
authors.forename: Chad
authors.initials: C
authors.lastname: Nusbaum
authors.forename: James E
authors.initials: JE
authors.lastname: Galagan
authors.forename: Bruce W
authors.initials: BW
authors.lastname: Birren
mesh_terms: D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D005800:Genes, Fungal / Q000235:genetics; D016681:Genome, Fungal; D006153:Guanosine Diphosphate / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000378:metabolism; D020082:Magnaporthe / Q000145:classification / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity; D012275:Oryza / Q000382:microbiology*; D010935:Plant Diseases / Q000382:microbiology; D017354:Point Mutation / Q000235:genetics; D020543:Proteome / Q000235:genetics / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D015398:Signal Transduction; D014774:Virulence / Q000235:genetics
chemical_list: D005656:Fungal Proteins; D020543:Proteome; D043562:Receptors, G-Protein-Coupled; D006153:Guanosine Diphosphate; D006160:Guanosine Triphosphate