Antifungal drugs and rational use of antifungals in treating invasive aspergillosis: the role of the hospital pharmacist.
OBJECTIVE
This review discusses the most common used antifungal agents in the treatment of invasive fungal infections. In addition, guidelines for the treatment of invasive aspergillosis, as used in the Ghent University Hospital, are described. Moreover, the importance of determining the effectiveness of antifungal therapy as well as the potential role of the hospital pharmacist in the management of this infection is highlighted.


METHODS
A review of the English-language literature was conducted using the MEDLINE database and scientific websites. Search terms including antimycotics, antifungal therapy and invasive aspergillosis were used to refine the search, and preference was given to studies published after 1992. This was completed with recent treatment guidelines.


RESULTS
An overview of the most recent advances in antifungal therapy is described. In addition, a flowchart for treatment of invasive aspergillosis (proven, probable or possible) has been developed.


CONCLUSIONS
Invasive fungal infections will remain a frequent and important complication of modern medicine. Considering the clinical and financial outcome of invasive fungal infections, the role of the hospital pharmacist can be a paramount to the treatment.
Bauters
Tiene G M
TG
Department of Pharmacy, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium. tiene.bauters@uzgent.be
Buyle
Franky M A
FM
Peleman
Renaat
R
Robays
Hugo
H
D000935:Antifungal Agents / Q000494:pharmacology / Q000592:standards / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy*; D004363:Drug Utilization; D006801:Humans; D009181:Mycoses / Q000188:drug therapy; D010607:Pharmacy Service, Hospital; D017410:Practice Guidelines as Topic
D000935:Antifungal Agents