NiCl2-catalyzed hydrophosphinylation.
[reaction: see text] A new nickel-based catalytic system has been developed for phosphorus-carbon bond formation. The addition of alkyl phosphinates to alkynes is catalyzed by nickel chloride in the absence of added ligand. The reaction generally proceeds in high yields, even with internal alkynes, which were poor substrates in our previously reported palladium-catalyzed hydrophosphinylation of alkyl phosphinates. The method is useful for the preparation of H-phosphinate esters and their derivatives. The one-pot synthesis of various important organophosphorus compounds is also demonstrated. The reaction can be conducted with microwave heating.
Ribière
Patrice
P
Department of Chemistry, Box 298860, Texas Christian University, Fort Worth, Texas 76129, USA.
Bravo-Altamirano
Karla
K
Antczak
Monika I
MI
Hawkins
Jennifer D
JD
Montchamp
Jean-Luc
JL