Complex between triple helix of collagen and double helix of DNA in aqueous solution.
We demonstrate in this paper that one example of a biologically important and molecular self-assembling complex system is a collagen-DNA ordered aggregate which spontaneously forms in aqueous solutions. Interaction between the collagen and the DNA leads to destruction of the hydration shell of the triple helix and stabilization of the double helix structure. From a molecular biology point of view this nano-scale self-assembling superstructure could increase the stability of DNA against the nucleases during collagen diseases and the growth of collagen fibrills in the presence of DNA.
Mrevlishvili
George M
GM
Department of Physics, Tbilisi State University, Tbilisi 0128, Georgia. gmrevli@ictsu.tsu.edu.ge
Svintradze
David V
DV
D003094:Collagen / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D008958:Models, Molecular; D020836:Protein Structure, Quaternary; D012996:Solutions; D013816:Thermodynamics; D014867:Water
D012996:Solutions; D014867:Water; D003094:Collagen; D004247:DNA