Synthesis and antibacterial properties of silver nanoparticles.
Nanometer sized silver particles were synthesized by inert gas condensation and co-condensation techniques. Both techniques are based on the evaporation of a metal into an inert atmosphere with the subsequent cooling for the nucleation and growth of the nanoparticles. The antibacterial efficiency of the nanoparticles was investigated by introducing the particles into a media containing Escherichia coli. The antibacterial investigations were performed in solution and on petri dishes. The silver nanoparticles were found to exhibit antibacterial effects at low concentrations. The antibacterial properties were related to the total surface area of the nanoparticles. Smaller particles with a larger surface to volume ratio provided a more efficient means for antibacterial activity. The nanoparticles were found to be completely cytotoxic to E. coli for surface concentrations as low as 8 microg of Ag/cm2.
Baker
C
C
Department of Materials Science and Engineering, University of Delaware, Newark, Deleware 19716, USA.
Pradhan
A
A
Pakstis
L
L
Pochan
Darrin J
DJ
Shah
S Ismat
SI
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry* / Q000633:toxicity; D004926:Escherichia coli / Q000187:drug effects; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry* / Q000382:microbiology* / Q000648:ultrastructure; D012834:Silver / Q000737:chemistry* / Q000633:toxicity; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D012834:Silver