title: [New dimeric phthalide derivative from Angelica sinensis].
abstract: OBJECTIVE
  To study the chemical constituents of the roots of Angelica sinensis.
  
  
  METHODS
  Silica gel column chromatography was used to separate the chemical constituents. Their structures were elucidated by chemical and spectral analysis (IR, MS, 1D and 2D NMR, etc.).
  
  
  RESULTS
  Besides three known phthalide derivatives, one new dimeric phthalide derivative and a pair of epimer were isolated and their structures were identified as Z-3',8',3'a,7'a-tetrahydro-6,3',7,7'a-diligustilide-8'-one (1), Z,Z'-6,6',7,3'a-diligustilide (2) and the 8-epimer (3) of 2 on the basis of spectral data.
  
  
  CONCLUSIONS
  Compound 1 is a new dimeric phthalide derivative, and compound 3 was first reported from radix Angelica
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
authors.forename: Dong-min
authors.initials: DM
authors.lastname: Su
authors.forename: Shi-shan
authors.initials: SS
authors.lastname: Yu
authors.forename: Hai-lin
authors.initials: HL
authors.lastname: Qin
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D029971:Angelica sinensis / Q000737:chemistry*; D001572:Benzofurans; D008968:Molecular Conformation; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001572:Benzofurans; C509377:Z-3',8',3'a,7'a-tetrahydro-6,3',7,7'a-diligustilide-8'-one; C523615:levistolide A; D015107:4-Butyrolactone