title: Dynamic optical imaging.
abstract: The main direction in modern imaging is increasing the spatial resolution and selectivity for pathology
  pattern recognition at the microscale. Dynamic optical imaging (DOl) has enormous potential in the selectivity
  of description of living tissue state at cellular and subcellular levels. However, multiple light
  scattering creates considerable difficulties in revealing the tissue microstructure in its depth. On the other
  hand, along with changes in the microstructure, pathology should also manifest itself in the integral macroscopic
  pattern of the tissue. Actually, living tissue, as a distributed active media with well-developed reception
  and self-regulation, is characterized by a high spatial synergy. In such a media, even morphologically
  small pathology could disturb tissue functioning in a rather extended area. As a result, after some definite
  time, a diffuse "field" of the pathological phenomena appears even in the morphological image. Since optical
  contrast is determined by tissue components (such as blood), which actively participate in physiological functioning,
  the distributed functional pattern of the tissue is reflected in optical images in the form of spatiotemporal
  modulation of the optical density. This observation opens up the possibility of investigating the diffuse
  pattern of the pathology at the functional stage of its development, even before the actual appearance of
  noticeable morphological changes .
authors.affiliation: Dynamics Imaging, Inc., Washington Township, NJ, USA.
authors.forename: E
authors.initials: E
authors.lastname: Godik
authors.forename: T
authors.initials: T
authors.lastname: Gergely
authors.forename: V
authors.initials: V
authors.lastname: Liger
authors.forename: V
authors.initials: V
authors.lastname: Zlatov
authors.forename: A
authors.initials: A
authors.lastname: Taratorin