title: Aryl sulfones: a new class of gamma-secretase inhibitors.
abstract: The development of a novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived gamma-secretase inhibitors for the potential treatment of Alzheimer's disease is described.
authors.affiliation: Department of Medicinal Chemistry, Merck Sharp & Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK. martin_teall@merck.com
authors.forename: Martin
authors.initials: M
authors.lastname: Teall
authors.forename: Paul
authors.initials: P
authors.lastname: Oakley
authors.forename: Timothy
authors.initials: T
authors.lastname: Harrison
authors.forename: Duncan
authors.initials: D
authors.lastname: Shaw
authors.forename: Euan
authors.initials: E
authors.lastname: Kay
authors.forename: Jason
authors.initials: J
authors.lastname: Elliott
authors.forename: Ute
authors.initials: U
authors.lastname: Gerhard
authors.forename: José L
authors.initials: JL
authors.lastname: Castro
authors.forename: Mark
authors.initials: M
authors.lastname: Shearman
authors.forename: Richard G
authors.initials: RG
authors.lastname: Ball
authors.forename: Nancy N
authors.initials: NN
authors.lastname: Tsou
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors*; D010450:Endopeptidases; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008958:Models, Molecular; D013450:Sulfones / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D013450:Sulfones; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human