[Detection of lymphoproliferative response in monkeys innoculated with dengue 4 virus].
A group of 6 Cynomolgus monkeys was immunized with dengue 4 virus (H247 standard strain). 60 days after innoculation the cellular proliferation against the same serotype as well as against hetereologous serotypes 1 and 2 was measured. A proliferative response predominantly of the specific serotype and some cross reactivity were detected. These results showed a behavior of primates similar in some extent to that of human beings and mice regarding the specific serotype and cross serotype response to dengue virus.
García
Gissel
G
Instituto de Medicina Tropical "Pedro Kouni", Autopista Novia del Mediodía, km 6 1/2 La Lisa, Apartado Postal 601. Marianao 13, Ciudad de La Habana, Cuba. ciipk@ipk.sld.cu
Alvarez
Mailing
M
Santana
Elaine
E
Martínez
José Rafael
JR
Alvarez
Alejandro
A
Rodríguez
Rosmary
R
Guzmán
María G
MG
D000818:Animals; D003715:Dengue / Q000276:immunology*; D003716:Dengue Virus / Q000145:classification / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D008252:Macaca fascicularis; D012703:Serotyping