Catalytic asymmetric synthesis of esters from ketenes.
By building on elementary principles of Brønsted acid-base chemistry, a nucleophile-catalyzed method for the asymmetric synthesis of esters from ketenes has been transformed into a much more versatile and effective Brønsted acid-catalyzed process. The product aryl esters can be converted into useful derivatives, such as enantioenriched alcohols and carboxylic acids.
Wiskur
Sheryl L
SL
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Fu
Gregory C
GC
D002384:Catalysis; D004952:Esters / Q000138:chemical synthesis*; D005030:Ethylenes / Q000737:chemistry*; D005296:Ferrous Compounds / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D000075163:Metallocenes; D013237:Stereoisomerism
D004952:Esters; D005030:Ethylenes; D005296:Ferrous Compounds; D007659:Ketones; D000075163:Metallocenes; C008223:ketene; C004998:ferrocene