title: Three-dimensional dose verification of the clinical application of gamma knife stereotactic radiosurgery using polymer gel and MRI.
abstract: This work seeks to verify multi-shot clinical applications of stereotactic radiosurgery with a Leksell Gamma Knife model C unit employing a polymer gel-MRI based experimental procedure, which has already been shown to be capable of verifying the precision and accuracy of dose delivery in single-shot gamma knife applications. The treatment plan studied in the present work resembles a clinical treatment case of pituitary adenoma using four 8 mm and one 14 mm collimator helmet shots to deliver a prescription dose of 15 Gy to the 50% isodose line (30 Gy maximum dose). For the experimental dose verification of the treatment plan, the same criteria as those used in the clinical treatment planning evaluation were employed. These included comparison of measured and GammaPlan calculated data, in terms of percentage isodose contours on axial, coronal and sagittal planes, as well as 3D plan evaluation criteria such as dose-volume histograms for the target volume, target coverage and conformity indices. Measured percentage isodose contours compared favourably with calculated ones despite individual point fluctuations at low dose contours (e.g., 20%) mainly due to the effect of T2 measurement uncertainty on dose resolution. Dose-volume histogram data were also found in a good agreement while the experimental results for the percentage target coverage and conformity index were 94% and 1.17 relative to corresponding GammaPlan calculations of 96% and 1.12, respectively. Overall, polymer gel results verified the planned dose distribution within experimental uncertainties and uncertainty related to the digitization process of selected GammaPlan output data.
authors.affiliation: Nuclear and Particle Physics Section, Physics Department, University of Athens, Panepistimioupolis, Ilisia 15771, Athens, Greece. ppapagi@cc.uoa.gr
authors.forename: P
authors.initials: P
authors.lastname: Papagiannis
authors.forename: P
authors.initials: P
authors.lastname: Karaiskos
authors.forename: M
authors.initials: M
authors.lastname: Kozicki
authors.forename: J M
authors.initials: JM
authors.lastname: Rosiak
authors.forename: L
authors.initials: L
authors.lastname: Sakelliou
authors.forename: P
authors.initials: P
authors.lastname: Sandilos
authors.forename: I
authors.initials: I
authors.lastname: Seimenis
authors.forename: M
authors.initials: M
authors.lastname: Torrens
mesh_terms: D000180:Acrylic Resins / Q000032:analysis / Q000737:chemistry / Q000528:radiation effects*; D000236:Adenoma / Q000532:radiotherapy; D019583:Dose Fractionation, Radiation; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010911:Pituitary Neoplasms / Q000532:radiotherapy; D011785:Quality Assurance, Health Care / Q000379:methods; D011874:Radiometry / Q000379:methods*; D016634:Radiosurgery / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D011881:Radiotherapy, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D000180:Acrylic Resins; C016680:polyacrylamide gels