title: Direct one-pot conversion of acylated carbohydrates into their alkylated derivatives under heterogeneous reaction conditions using solid NaOH and a phase transfer catalyst.
abstract: A convenient one-pot protocol for the direct conversion of acyl-protected carbohydrates into their alkylated counterparts has been developed by using alkyl halides in the presence of solid sodium hydroxide and a phase transfer catalyst. These economically convenient, mild, two-phase reaction conditions allow the preparation of a variety of monosaccharide intermediates for use in the synthesis of complex oligosaccharides.
authors.affiliation: Medicinal and Process Chemistry Division, Central Drug Research Institute (CDRI), Chattar Manzil Palace, Lucknow 226 001, UP, India.
authors.forename: Soni Kamlesh
authors.initials: SK
authors.lastname: Madhusudan
authors.forename: Geetanjali
authors.initials: G
authors.lastname: Agnihotri
authors.forename: Devendra S
authors.initials: DS
authors.lastname: Negi
authors.forename: Anup Kumar
authors.initials: AK
authors.lastname: Misra
mesh_terms: D000107:Acetylation; D000478:Alkylation; D002241:Carbohydrates / Q000737:chemistry*; D012972:Sodium Hydroxide / Q000737:chemistry*
chemical_list: D002241:Carbohydrates; D012972:Sodium Hydroxide