title: Apolipoprotein AV variants do not affect C-reactive protein levels in Caucasian males.
abstract: The important role of APOAV gene variants in determination of plasma triglyceride levels has been shown in many population studies. Recently, an influence of APOAV T-1131>C polymorphism on C-reactive protein (CRP) in young Korean males has been reported. We have therefore analyzed a putative association between T-1131>C, Ser19>Trp and Val153>Met APOAV variants (PCR and restriction analysis) and CRP concentrations in 1119 Caucasian males, aged between 28 and 67 years (49.2+/-10.8 years). The frequency of C allele carriers was lower in Caucasians than in Koreans (15.5% vs. 46.2%). CRP levels did not differ between T/T homozygotes (n=946, 1.61+/-2.05 mg/l) and carriers of the C allele (n=173, 1.67+/-1.95 mg/l). Thus, in contrast to Korean males, T-1131>C APOAV variant has no effect on plasma concentrations of CRP in a large group of Caucasian males. Other APOAV variants (Ser19>Trp and Val153>Met) did not also influence plasma concentrations of CRP. APOAV variants are unlikely to be an important genetic determinant of plasma CRP concentrations in Caucasian males.
authors.affiliation: Center for Experimental Medicine and Department of Preventive Cardiology, Institute for Clinical and Experimental Medicine, IKEM-CEM-LMG, Vídenská 1958/9, 140 21 Prague 4, Czech Republic. jahb@medicon.cz
authors.forename: J A
authors.initials: JA
authors.lastname: Hubácek
authors.forename: Z
authors.initials: Z
authors.lastname: Skodová
authors.forename: V
authors.initials: V
authors.lastname: Lánská
authors.forename: P
authors.initials: P
authors.lastname: Stávek
authors.forename: V
authors.initials: V
authors.lastname: Adámková
authors.forename: R
authors.initials: R
authors.lastname: Poledne
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A / Q000097:blood / Q000235:genetics*; D002097:C-Reactive Protein / Q000032:analysis*; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D044465:White People
chemical_list: C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A; D002097:C-Reactive Protein