title: [Synthesis and antibacterial activity of ciprofloxacin derivatives].
abstract: OBJECTIVE
  To study the synthesis and antibacterial activity of ciprofloxacin derivatives.
  
  
  METHODS
  Ciprofloxacin derivatives were synthesized primarily from 2-methyl-5-nitroimidazol and ciprofloxacin through nucleophilic substitution. The antibacterial activity of the synthesized compounds were tested.
  
  
  RESULTS
  Nine new compounds were synthesized. The structure of the title compounds were confirmed by 1H NMR, MS and element analysis.
  
  
  CONCLUSIONS
  Compounds II, IVC and IVD showed appreciable antibacterial activity, and were worth further studying.
authors.affiliation: Department of Medicinal Chemistry, Wenzhou Medical College, Wenzhou 325035, China. yfq@wzmc.net
authors.forename: Fa-qing
authors.initials: FQ
authors.lastname: Ye
authors.forename: You-mei
authors.initials: YM
authors.lastname: Ding
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: Song
authors.initials: S
authors.lastname: Ye
authors.forename: Zhi-xiang
authors.initials: ZX
authors.lastname: Chen
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D051379:Mice; D015394:Molecular Structure; D009593:Nitroimidazoles
chemical_list: D000890:Anti-Infective Agents; D009593:Nitroimidazoles; C052586:2-methyl-5-nitroimidazole; D002939:Ciprofloxacin