Preparation and characterization of n-dodecyl-ferulate-loaded solid lipid nanoparticles (SLN).
Solid lipid nanoparticles (SLN) containing a novel potential sunscreen n-dodecyl-ferulate (ester of ferulic acid) were developed. The preparation and stability parameters of n-dodecyl-ferulate-loaded SLN have been investigated concerning particle size, surface electrical charge (zeta potential) and matrix crystallinity. The chemical stability of n-dodecyl-ferulate at high temperatures was also assessed by thermal gravimetry analysis. For the selection of the appropriated lipid matrix, chemically different lipids were melted with 4% (m/m) of active and lipid nanoparticles were prepared by the so-called high pressure homogenization technique. n-Dodecyl-ferulate-loaded SLN prepared with cetyl palmitate showed the lowest mean particle size and polydispersity index, as well as the highest physical stability during storage time of 21 days at 4, 20 and 40 degrees C. These colloidal dispersions containing the sunscreen also exhibited the common melting behaviour of aqueous SLN dispersions.
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Department of Pharmaceutics, Biopharmaceutics and Biotechnology, Free University of Berlin, Kelchstr. 31, D-12169 Berlin, Germany.
Anselmi
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Centini
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Müller
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D003373:Coumaric Acids / Q000008:administration & dosage* / Q000737:chemistry; D004355:Drug Stability; D007850:Lauric Acids / Q000008:administration & dosage; D049329:Nanostructures; D012995:Solubility; D013473:Sunscreening Agents / Q000008:administration & dosage*
D003373:Coumaric Acids; D007850:Lauric Acids; D013473:Sunscreening Agents; C004999:ferulic acid