title: Silent pituitary macroadenoma co-secreting growth hormone and thyroid stimulating hormone.
abstract: Silent pituitary adenomas are a group of tumors showing heterogenous morphological features with no hormonal function observed clinically. To date no explanation has been provided as to why these tumors remain "silent". We report a case of a silent macroadenoma with both growth hormone (GH) and thyroid stimulating hormone (TSH) staining and secretion but with no clinical manifestations, in particular, the absence of features of acromegaly or hyperthyroidism. The relevant literature is reviewed.
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, Baskent University.
authors.forename: Orhan
authors.initials: O
authors.lastname: Sen
authors.forename: M Eda
authors.initials: ME
authors.lastname: Ertorer
authors.forename: M Volkan
authors.initials: MV
authors.lastname: Aydin
authors.forename: Bulent
authors.initials: B
authors.lastname: Erdogan
authors.forename: Nur
authors.initials: N
authors.lastname: Altinors
authors.forename: Suzan
authors.initials: S
authors.lastname: Zorludemir
authors.forename: Nilgun
authors.initials: N
authors.lastname: Guvener
mesh_terms: D000236:Adenoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D005260:Female; D005951:Glucose Tolerance Test; D019382:Human Growth Hormone / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D019635:Neurosurgical Procedures; D010907:Pituitary Hormones / Q000097:blood; D010911:Pituitary Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000378:metabolism*
chemical_list: D010907:Pituitary Hormones; D019382:Human Growth Hormone; D013972:Thyrotropin