[Metabolic pathways of dipfluzine in rats].
OBJECTIVE
To investigate the metabolic pathways of dipfluzine in rats.


METHODS
After an oral dose of dipfluzine (80 mg x kg(-1)) to rats, urine was collected for 12 h. The metabolites of dipfluzine in urine were chromatographed and identified by LC/DAD/MS methods.


RESULTS
In the rat urine, there were 1-(4-fluorophenyl)-4-piperazinylbutanone and its glucuronide, 4-hydroxybenzophenone and its glucuronide, 4-fluoro-gamma-hydroxybenzenebutanoic acid and its glucuronide and sulfate, diphenylmethanol and its glucuronide, dipfluzine, and benzophenone.


CONCLUSIONS
In rats, dipfluzine was mainly metabolized in the pathways of N-desalkylation at 1- and 4-positions of piperazine ring. Some of metabolites were further conjugated with glucuronic acid and/or sulfuric acid.
Liu
Hui-chen
HC
Department of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China.
Du
Yu-min
YM
Wang
Yong-li
YL
D000818:Animals; D001577:Benzophenones / Q000652:urine*; D002853:Chromatography, Liquid; D002936:Cinnarizine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000652:urine; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D020719:Glucuronides / Q000652:urine; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D001577:Benzophenones; D020719:Glucuronides; C024292:4-hydroxybenzophenone; D002936:Cinnarizine; C047723:benzophenone; C065758:dipfluzine