Solution conformations of amphidinolide H.
Solution conformations of amphidinolide H (1), a 26-membered macrolide exhibiting potent cytotoxic and antitumor activity, in CDCl3 and DMSO-d6 were investigated on the basis of NMR data, distance geometry calculation, and restrained energy minimization. Three-dimensional conformations in CDCl3 were suggested to be close to the X-ray structure of 1, while those in DMSO-d6 were indicated to be different from both those in CDCl3 and the X-ray structure.
Shimbo
Kazutaka
K
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Nozawa
Kohei
K
Tsuda
Masashi
M
Kobayashi
Jun'ichi
J
D018360:Crystallography, X-Ray; D018942:Macrolides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D012996:Solutions; D000097442:Amphidinolides
D018942:Macrolides; D012996:Solutions; C414664:amphidinolide H; D000097442:Amphidinolides