title: Acetylcholinesterase inhibitors reduce brain and blood interleukin-1beta production.
abstract: Overproduction of interleukin-1 within the brain is associated with Alzheimer's disease and other neurological conditions. We report that peripheral administration of the acetylcholinesterase inhibitors tacrine, rivastigmine, neostigmine, or EN101 (an antisense oligonucleotide directed at acetylcholinesterase messenger RNA) to mice significantly attenuated the production of interleukin-1beta in the hippocampus and blood, concomitantly with the reduction in acetylcholinesterase activity. These findings demonstrate that cholinergic enhancement produces central and peripheral antiinflammatory effects and suggest a novel therapeutic mechanism for acetylcholinesterase inhibitors.
authors.affiliation: Department of Psychology, The Hebrew University of Jerusalem, Jerusalem, Israel.
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Pollak
authors.forename: Adi
authors.initials: A
authors.lastname: Gilboa
authors.forename: Ofra
authors.initials: O
authors.lastname: Ben-Menachem
authors.forename: Tamir
authors.initials: T
authors.lastname: Ben-Hur
authors.forename: Hermona
authors.initials: H
authors.lastname: Soreq
authors.forename: Raz
authors.initials: R
authors.lastname: Yirmiya
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D007375:Interleukin-1 / Q000096:biosynthesis* / Q000097:blood; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009388:Neostigmine / Q000494:pharmacology; D009838:Oligodeoxyribonucleotides; D009841:Oligonucleotides / Q000494:pharmacology; D016376:Oligonucleotides, Antisense / Q000494:pharmacology; D048448:Phenylcarbamates / Q000494:pharmacology; D000068836:Rivastigmine; D013619:Tacrine / Q000494:pharmacology
chemical_list: D002800:Cholinesterase Inhibitors; C477243:EN101; D007375:Interleukin-1; D008070:Lipopolysaccharides; D009838:Oligodeoxyribonucleotides; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense; D048448:Phenylcarbamates; D009388:Neostigmine; D013619:Tacrine; D000068836:Rivastigmine