Determination of ambroxol in an automated multi-pumping pulsed flow system.
A new flow methodology exploiting the multi-pumping approach was developed for the spectrophotometric determination of ambroxol hydrochloride in pharmaceutical preparations. The flow manifold was implemented by using, exclusively, multiple solenoid-actuated micro-pumps, which acted simultaneously as sample insertion, solutions propelling and reagents commutation units. Linear calibration plots were obtained over an ambroxol concentration ranging from 10 to 200 mg l(-1) (r.s.d. < 0.5%, n = 15) and a sampling rate of about 60 samples per hour (flow rate = 1.92 ml min(-1), sample volume = 80 microl).
Santos
João L M
JL
REQUIMTE, Departamento de Química-Fisica, Faculdade de Farmácia, Universidade do Porto, Rua Anibal Cunha 164, 4050-047 Porto, Portugal. joaolms@ff.up.pt
Clausse
Arnaud
A
Lima
José L F C
JL
Saraiva
M L M F S
ML
Rangel
António O S
AO
D000551:Ambroxol / Q000032:analysis*; D002138:Calibration; D005100:Expectorants / Q000032:analysis*; D017022:Flow Injection Analysis; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D012996:Solutions
D005100:Expectorants; D007202:Indicators and Reagents; D012996:Solutions; D000551:Ambroxol