title: Addiction in Parkinson's disease: impact of subthalamic nucleus deep brain stimulation.
abstract: In Parkinson's disease, dopamine dysregulation syndrome (DDS) is characterized by severe dopamine addiction and behavioral disorders such as manic psychosis, hypersexuality, pathological gambling, and mood swings. Here, we describe the case of 2 young parkinsonian patients suffering from disabling motor fluctuations and dyskinesia associated with severe DDS. In addition to alleviating the motor disability in both patients, subthalamic nucleus (STN) deep brain stimulation greatly reduced the behavioral disorders as well as completely abolished the addiction to dopaminergic treatment. Dopaminergic addiction in patients with Parkinson's disease, therefore, does not constitute an obstacle to high-frequency STN stimulation, and this treatment may even cure the addiction.
authors.affiliation: Department of Neurology, University Hospital Timone, Marseille, France. twitjas@yahoo.com
authors.forename: Tatiana
authors.initials: T
authors.lastname: Witjas
authors.forename: Christelle
authors.initials: C
authors.lastname: Baunez
authors.forename: Jean Marc
authors.initials: JM
authors.lastname: Henry
authors.forename: Marie
authors.initials: M
authors.lastname: Delfini
authors.forename: Jean
authors.initials: J
authors.lastname: Regis
authors.forename: André Ali
authors.initials: AA
authors.lastname: Cherif
authors.forename: Jean Claude
authors.initials: JC
authors.lastname: Peragut
authors.forename: Jean Philippe
authors.initials: JP
authors.lastname: Azulay
mesh_terms: D000328:Adult; D016739:Behavior, Addictive / Q000150:complications / Q000628:therapy*; D002985:Clinical Protocols; D046690:Deep Brain Stimulation / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000628:therapy*; D020531:Subthalamic Nucleus / Q000528:radiation effects*