title: Relationship between serum lipoprotein(a) concentrations and coronary vasomotion in coronary spastic angina.
abstract: BACKGROUND
  Elevated lipoprotein(a) (Lp(a)) concentrations are reported to impair endothelium-dependent vasodilatation of the epicardial coronary artery. However, the effects on vasomotor abnormalities in coronary spastic angina (CSA) have not been thoroughly investigated.
  
  
  RESULTS
  In the present study 80 sites of spasm (spastic sites) without significant organic stenosis (% diameter stenosis <50%) were assessed in 80 patients with CSA diagnosed by intracoronary ergonovine (EM) test. Spastic sites were divided into 2 groups: Group 1 included 30 sites provoked by the full dose (=50 microg) of EM, and Group 2 included 50 sites provoked with less than 50 microg (34.7+/-8.2 microg). Control subjects (n=22) did not show coronary spasm with the EM test. Serum Lp(a) concentrations were measured in all patients. Group 2 had a significantly greater basal coronary artery tone in the spastic sites than Group 1 (p<0.001). Lp(a) level in Group 2 was significantly higher compared with both the control group and Group 1 (p<0.05 by analysis of variance). Multivariate analysis confirmed that only serum Lp(a) concentration was associated with low-dose EM spasm provocation.
  
  
  CONCLUSIONS
  Serum Lp(a) concentration could be a marker for high disease activity in CSA.
authors.affiliation: Division of Cardiology, Graduate School of Medical and Dental Sciences, Niigata University. keitsuchida97@kjb.biglobe.ne.jp
authors.forename: Keiichi
authors.initials: K
authors.lastname: Tsuchida
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Hori
authors.forename: Naohito
authors.initials: N
authors.lastname: Tanabe
authors.forename: Yashiro
authors.initials: Y
authors.lastname: Makiyama
authors.forename: Takuya
authors.initials: T
authors.lastname: Ozawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Saigawa
authors.forename: Ritsuo
authors.initials: R
authors.lastname: Watanabe
authors.forename: Takayuki
authors.initials: T
authors.lastname: Tanaka
authors.forename: Akimitsu
authors.initials: A
authors.lastname: Nasuno
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fukunaga
authors.forename: Tohru
authors.initials: T
authors.lastname: Mezaki
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Yoshifusa
authors.initials: Y
authors.lastname: Aizawa
mesh_terms: D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000097:blood* / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D003329:Coronary Vasospasm / Q000097:blood* / Q000503:physiopathology; D003331:Coronary Vessels / Q000503:physiopathology; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014664:Vasodilation
chemical_list: D015415:Biomarkers; D017270:Lipoprotein(a)