A South Australian population-based study of congenital talipes equinovarus.
The aims of this study were to provide a population-based prevalence for congenital talipes equinovarus (CTEV), to conduct an epidemiological investigation into the risk factors for CTEV and describe associated features. The study used a retrospective case-control design of CTEV notified to the South Australian Birth Defects Register between 1986 and 1996 inclusive, linking characteristics of mother and baby from the perinatal data collection. The prevalence of isolated CTEV was 1.1/1000 total births (n = 231). Four factors were significantly associated with an increased risk of CTEV: maternal Aboriginal race (ORadj = 2.0; 95% CI 1.1, 3.6), male gender (ORadj = 2.4; 95% CI 1.8, 3.2), maternal anaemia (ORadj = 1.8; 95% CI 1.0, 2.9) and maternal hyperemesis (ORadj = 3.6; 95% CI 1.3, 9.8). The prevalence of CTEV associated with another birth defect or syndrome (n = 157) was 0.7/1000 total births. CTEV was associated with specific birth defects and also with oligohydramnios when another birth defect was present.
Byron-Scott
R
R
South Australian Birth Defects Register, South Australian Clinical Genetics Service, Women's and Children's Hospital, Adelaide, South Australia.
Sharpe
P
P
Hasler
C
C
Cundy
P
P
Hirte
C
C
Chan
A
A
Scott
H
H
Baghurst
P
P
Haan
E
E
D000740:Anemia / Q000453:epidemiology; D003025:Clubfoot / Q000453:epidemiology* / Q000401:mortality; D000013:Congenital Abnormalities / Q000453:epidemiology; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000453:epidemiology; D007231:Infant, Newborn; D008297:Male; D016104:Oligohydramnios / Q000453:epidemiology; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000453:epidemiology; D011256:Pregnancy Outcome / Q000453:epidemiology; D012737:Sex Factors; D013021:South Australia / Q000453:epidemiology