Synthesis and evaluation of 3D templates based on a taxane skeleton to circumvent P-glycoprotein-associated multidrug resistance of cancer.
We have developed a practical synthetic route to construct C-aromatic taxane derivatives as three-dimension templates by way of intramolecular alkylation. The usefulness of synthesized compounds as the core template was evaluated by using a newly developed screening system for P-glycoprotein.
Takahashi
Takashi
T
Department of Applied Chemistry, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro, Tokyo 152-8552, Japan. ttak@apc.titech.ac.jp
Nakai
Kazuoki
K
Doi
Takayuki
T
Yasunaga
Masa
M
Nakagawa
Hiroshi
H
Ishikawa
Toshihisa
T
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000737:chemistry / Q000502:physiology*; D001952:Bridged-Ring Compounds / Q000737:chemistry*; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D043823:Taxoids / Q000737:chemistry*
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D001952:Bridged-Ring Compounds; D043823:Taxoids; C080625:taxane