Interleukin-15 enhances innate and adaptive immune responses to blood-stage malaria infection in mice.
Compared to C57BL/6 wild-type mice, interleukin-15(-/-) (IL-15(-/-)) mice showed delayed clearance of Plasmodium chabaudi AS infection, lower type 1 cytokine production, impaired dendritic cell and NK cell functions, and lower titers of malaria-specific antibodies. Thus, IL-15 supports early control and timely resolution of blood-stage malaria through promotion of Th1-dependent innate and adaptive immune responses.
Ing
Rebecca
R
Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, 1650 Cedar Ave., Montreal, Quebec H3G 1A4, Canada.
Gros
Philippe
P
Stevenson
Mary M
MM
D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D016207:Cytokines / Q000097:blood; D003713:Dendritic Cells / Q000276:immunology; D007113:Immunity, Innate; D019409:Interleukin-15 / Q000235:genetics / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology; D008288:Malaria / Q000276:immunology* / Q000401:mortality / Q000469:parasitology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018512:Parasitemia / Q000276:immunology* / Q000401:mortality / Q000469:parasitology; D016788:Plasmodium chabaudi / Q000276:immunology / Q000472:pathogenicity*; D018417:Th1 Cells / Q000276:immunology
D000913:Antibodies, Protozoan; D016207:Cytokines; D019409:Interleukin-15