title: Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 3: 8-Thiocarboxamido and 8-thioformamido derivatives of cyclazocine.
abstract: 8-Position variants of cyclazocine have been made where the phenolic 8-OH was replaced by thioamide, amidine, guanidine, urea and thiourea groups. High affinity for opioid receptors was observed for the 8-CSNH2 and 8-NHCHS analogues indicating that these groups are isosteric with not only the 8-OH but with the previously synthesized 8-CONH2 and 8-NHCHO cyclazocine derivatives.
authors.affiliation: Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY 12180, USA. wentmp@rpi.edu
authors.forename: Mark P
authors.initials: MP
authors.lastname: Wentland
authors.forename: Xufeng
authors.initials: X
authors.lastname: Sun
authors.forename: Yigong
authors.initials: Y
authors.lastname: Bu
authors.forename: Rongliang
authors.initials: R
authors.lastname: Lou
authors.forename: Dana J
authors.initials: DJ
authors.lastname: Cohen
authors.forename: Jean M
authors.initials: JM
authors.lastname: Bidlack
mesh_terms: D003496:Cyclazocine / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D003496:Cyclazocine