title: Quantification of resting myocardial blood flow in a pig model of acute ischemia based on first-pass MRI.
abstract: Qualitative and semiquantitative contrast-enhanced (CE) dynamic perfusion MRI techniques are established as noninvasive diagnostic means of assessing coronary artery disease. However, to date quantification of myocardial blood flow (MBF) has not reached the same acceptance as MBF quantification with nuclear techniques. To validate quantification of MBF at rest using the extracellular contrast agent (CA) Gd-DTPA, we performed an animal study in a pig model of acute myocardial ischemia. We quantified MBF from MRI data with a mathematical model (MMID4) of the underlying vasculature. These MBF results were subsequently compared with the results from fluorescent microspheres. The study showed a correlation of r = 0.66 between MBF estimates obtained with MRI and those obtained with fluorescent microspheres. The correlation for ischemic and nonischemic myocardium was r = 0.86 and r = 0.47, respectively. In conclusion, quantification of resting MBF using MMID4 is a valid method under conditions of acute myocardial ischemia.
authors.affiliation: Department of Radiology, Johannes Gutenberg University, Mainz, Germany.
authors.forename: Melanie
authors.initials: M
authors.lastname: Schmitt
authors.forename: Georg
authors.initials: G
authors.lastname: Horstick
authors.forename: Steffen E
authors.initials: SE
authors.lastname: Petersen
authors.forename: Andrea
authors.initials: A
authors.lastname: Karg
authors.forename: Nico
authors.initials: N
authors.lastname: Hoffmann
authors.forename: Thorsten
authors.initials: T
authors.lastname: Gumbrich
authors.forename: Nico
authors.initials: N
authors.lastname: Abegunewardene
authors.forename: Wolfgang G
authors.initials: WG
authors.lastname: Schreiber
mesh_terms: D000208:Acute Disease; D000818:Animals; D003287:Contrast Media; D003326:Coronary Circulation; D004195:Disease Models, Animal; D019786:Gadolinium DTPA; D008279:Magnetic Resonance Imaging / Q000379:methods*; D017202:Myocardial Ischemia / Q000175:diagnosis*; D018709:Statistics, Nonparametric; D013552:Swine
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA