title: Dual modality of 18F-fluorodeoxyglucose-positron emission tomography/computed tomography in patients with cervical carcinoma of unknown primary.
abstract: OBJECTIVE
  To evaluate an optimized F-18-flurodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) acquisition protocol for head and neck cancer and assess the usefulness of combined FDG-PET/CT in locating unknown primary tumors in patients with biopsy-proven cervical lymph node metastases.
  
  
  METHODS
  Twenty-one patients with cervical lymph node metastases of unknown primary tumors underwent staging with FDG-PET/CT. The images of FDG-PET alone, CT alone, FDG-PET/CT read side by side and fused and FDG-PET/CT were evaluated separately by 2 physicians. Imaging results were correlated with either histology (n = 14) or clinical follow-up (n = 7).
  
  
  RESULTS
  On the fused FDG-PET/CT images, primary tumors were identified in 12 patients (57%); with FDG-PET alone and FDG-PET and CT read side by side 11 (52%) primary tumors were found while CT alone identified 5 (23%) primary tumors.
  
  
  CONCLUSIONS
  Our data indicate that fused FDG-PET and CT images increased the sensitivity of detecting carcinoma of unknown primary (CUP) tumors compared to CT alone, but not to FDG-PET alone or FDG-PET and CT read side by side. Hence accurate fusion of functional and morphologic data by FDG-PET/CT is a promising imaging modality in the clinical workup of patients with cervical CUP tumors.
authors.affiliation: Clinic of Nuclear Medicine, University Hospital Essen, Essen, Germany. lutz.freudenberg@uni-essen.de
authors.forename: Lutz S
authors.initials: LS
authors.lastname: Freudenberg
authors.forename: Markus
authors.initials: M
authors.lastname: Fischer
authors.forename: Gerald
authors.initials: G
authors.lastname: Antoch
authors.forename: Walter
authors.initials: W
authors.lastname: Jentzen
authors.forename: Andreas
authors.initials: A
authors.lastname: Gutzeit
authors.forename: Sandra J
authors.initials: SJ
authors.lastname: Rosenbaum
authors.forename: Andreas
authors.initials: A
authors.lastname: Bockisch
authors.forename: Thomas
authors.initials: T
authors.lastname: Egelhof
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009382:Neoplasms, Unknown Primary / Q000473:pathology*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18