GSTT1 and GSTM1 polymorphisms are associated with improvement in seminal findings after varicocelectomy.
To identify the best candidates for varicocelectomy, we evaluated the genetic polymorphism in glutathione S-transferase (GST) T1 and M1 in 38 infertile men with high-grade varicocele testis who underwent varicocelectomy. The response rate to varicocelectomy is significantly higher in patients with the GSTT1-wt genotype than the GSTT1-null genotype, and the response rate became higher in combination with the GSTM1 genotype.
Okubo
Kazutoshi
K
Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Nagahama
Kanji
K
Kamoto
Toshiyuki
T
Okuno
Hiroshi
H
Ogawa
Osamu
O
Nishiyama
Hiroyuki
H
D016009:Chi-Square Distribution; D016001:Confidence Intervals; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D012661:Semen / Q000166:cytology* / Q000502:physiology; D013076:Sperm Count / Q000706:statistics & numerical data; D018709:Statistics, Nonparametric; D014646:Varicocele / Q000235:genetics* / Q000601:surgery*
D005982:Glutathione Transferase; C413545:glutathione S-transferase T1