title: Randomized controlled trial of a web-based computer-tailored smoking cessation program as a supplement to nicotine patch therapy.
abstract: OBJECTIVE
  To assess the efficacy of World Wide Web-based tailored behavioral smoking cessation materials among nicotine patch users.
  
  
  METHODS
  Two-group randomized controlled trial.
  
  
  METHODS
  World Wide Web in England and Republic of Ireland.
  
  
  METHODS
  A total of 3971 subjects who purchased a particular brand of nicotine patch and logged-on to use a free web-based behavioral support program.
  
  
  METHODS
  Web-based tailored behavioral smoking cessation materials or web-based non-tailored materials.
  
  
  METHODS
  Twenty-eight-day continuous abstinence rates were assessed by internet-based survey at 6-week follow-up and 10-week continuous rates at 12-week follow-up.
  
  
  RESULTS
  Using three approaches to the analyses of 6- and 12-week outcomes, participants in the tailored condition reported clinically and statistically significantly higher continuous abstinence rates than participants in the non-tailored condition. In our primary analyses using as a denominator all subjects who logged-on to the treatment site at least once, continuous abstinence rates at 6 weeks were 29.0% in the tailored condition versus 23.9% in the non-tailored condition (OR = 1.30; P = 0.0006); at 12 weeks continuous abstinence rates were 22.8% versus 18.1%, respectively (OR = 1.34; P = 0.0006). Moreover, satisfaction with the program was significantly higher in the tailored than in the non-tailored condition.
  
  
  CONCLUSIONS
  The results of this study demonstrate a benefit of the web-based tailored behavioral support materials used in conjunction with nicotine replacement therapy. A web-based program that collects relevant information from users and tailors the intervention to their specific needs had significant advantages over a web-based non-tailored cessation program.
authors.affiliation: University of Michigan Comprehensive Cancer Center, Ann Arbor 48109-0471, USA. strecher@umich.edu
authors.forename: Victor J
authors.initials: VJ
authors.lastname: Strecher
authors.forename: Saul
authors.initials: S
authors.lastname: Shiffman
authors.forename: Robert
authors.initials: R
authors.lastname: West
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D003131:Combined Modality Therapy; D004739:England; D005260:Female; D006801:Humans; D020407:Internet; D007494:Ireland; D008297:Male; D009538:Nicotine / Q000008:administration & dosage* / Q000627:therapeutic use; D018722:Nicotinic Agonists / Q000008:administration & dosage* / Q000627:therapeutic use; D010349:Patient Compliance; D016540:Smoking Cessation / Q000379:methods*; D013813:Therapy, Computer-Assisted / Q000379:methods*
chemical_list: D018722:Nicotinic Agonists; D009538:Nicotine