title: Synthesis of lactams via copper-catalyzed intramolecular vinylation of amides.
abstract: Copper-catalyzed intramolecular vinylation of iodoenamides were investigated for the first time. With CuI as the catalyst and N,N'-dimethylethylenediamine as the ligand, a number of iodoenamides underwent cyclization in dioxane leading to the formations of five- to seven-membered lactams in moderate to excellent yields.
authors.affiliation: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, P. R. China.
authors.forename: Tianshun
authors.initials: T
authors.lastname: Hu
authors.forename: Chaozhong
authors.initials: C
authors.lastname: Li
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D007769:Lactams / Q000138:chemical synthesis*; D015394:Molecular Structure
chemical_list: D000577:Amides; D007769:Lactams; D003300:Copper