Prognostic impact of diabetes mellitus in patients with acute decompensated heart failure.
The presence of diabetes mellitus (DM) adversely affects the natural history of heart failure (HF), but its prognostic significance is unknown in acute decompensated HF. Of the 498 patients enrolled with decompensated HF requiring intravenous vasoactive therapy, 236 (47.4%) had a previous diagnosis of DM. After 6 months, 113 patients (22.7%) had died. A Cox proportional-hazards model showed a significant association between DM and worse survival after hospital discharge. DM is common among patients admitted with decompensated HF, and diabetes-related biologic differences contribute to the progression of HF.
Burger
Andrew J
AJ
Beth Israel Deaconess Medical Center, Noninvasive Cardiology Laboratory, Boston, Massachusetts 02215, USA. aburger@bidmc.harvard.edu
Tsao
Lana
L
Aronson
Doron
D
D000208:Acute Disease; D003920:Diabetes Mellitus / Q000175:diagnosis*; D003925:Diabetic Angiopathies / Q000150:complications; D018450:Disease Progression; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000175:diagnosis* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D016019:Survival Analysis