[Role of S-100B for evaluation of traumatic brain injury in patients with alcohol intoxication].
The neuroprotein S-100B was identified as a possible marker for primary brain damage. The objective of this prospective study was to determine the diagnostic validity of plasma measurements of S-100B in patients with minor head injury and acute alcohol intoxication. The results of S-100B plasma levels were compared to the Glasgow-Coma-Scale score, the neurological examination and the CCT data. Median S-100B levels of the CCT+ patients were significantly increased compared to those of the CCT- patients without being influenced by alcohol. Increased S-100B plasma levels seem to indicate a primary brain damage.
Mussack
Thomas
T
Chirurgische Klinik und Poliklinik Innenstadt, Klinikum der Universität, München. Thomas.Mussack@med.uni-muenchen.de
Ladurner
Roland
R
D000328:Adult; D000435:Alcoholic Intoxication / Q000097:blood* / Q000150:complications; D015415:Biomarkers / Q000097:blood; D001930:Brain Injuries / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D011446:Prospective Studies; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*
D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins