title: Development of squamous cell carcinoma of the tongue during induction chemotherapy for acute myeloid leukemia.
abstract: Immunosuppression is a well-recognized cause of skin tumors, in particular squamous cell carcinomas (SCC). In patients with hematological malignancies undergoing chemotherapy, SCC has been reported late in the course of the disease or many years after completion of treatment. Here we report a patient with acute myeloid leukemia who developed a SCC of the tongue while receiving the third course of induction chemotherapy. This is the second such case in the medical literature. The role of immunosuppression, chemotherapy, the malignancy itself and possible genetic predisposition is discussed and the literature on this topic is reviewed.
authors.affiliation: Department of Hematology, School of Medicine, Gulhane Military Medical Academy, 06010 Etlik, Ankara, Turkey. aural@gata.edu.tr
authors.forename: Ali Ugur
authors.initials: AU
authors.lastname: Ural
authors.forename: Ferit
authors.initials: F
authors.lastname: Avcu
authors.forename: Mahmut Ilker
authors.initials: MI
authors.lastname: Yilmaz
authors.forename: Metin
authors.initials: M
authors.lastname: Guden
authors.forename: Bekir
authors.initials: B
authors.lastname: Ozturk
authors.forename: Ayhan
authors.initials: A
authors.lastname: Ozcan
authors.forename: Sefik
authors.initials: S
authors.lastname: Guran
authors.forename: Muhterem
authors.initials: M
authors.lastname: Bahce
authors.forename: Atilla
authors.initials: A
authors.lastname: Yalcin
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000276:immunology; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D016609:Neoplasms, Second Primary / Q000139:chemically induced* / Q000276:immunology; D012074:Remission Induction; D014062:Tongue Neoplasms / Q000139:chemically induced* / Q000276:immunology