Hypercalcemia in a patient with common variable immunodeficiency and renal granulomas.
Common variable immunodeficiency (CVID) is the most common primary immunodeficiency. A granulomatous form of the condition is recognized. Renal involvement is rare. The authors present the first case of CVID with biopsy-proven noncaseating renal granulomas, in association with hypercalcemia. The mechanism of hypercalcemia in granulomatous disorders, and the difficulty of differentiating granulomatous CVID from sarcoidosis, are discussed.
Meyer
Alex
A
Department of Nephrology and Immunology, and Histopathology, Royal Free Hospital, London, United Kingdom. ameyer@doctors.net.uk
Lachmann
Helen J
HJ
Webster
A David
AD
Burns
Aine
A
Thway
Khin
K
D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000188:drug therapy / Q000628:therapy; D003937:Diagnosis, Differential; D004893:Erythema Nodosum / Q000209:etiology; D006099:Granuloma / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology* / Q000503:physiopathology; D016756:Immunoglobulins, Intravenous; D007674:Kidney Diseases / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D012507:Sarcoidosis / Q000175:diagnosis; D013163:Splenomegaly / Q000209:etiology
D016756:Immunoglobulins, Intravenous; D011239:Prednisolone