title: Early regression in social communication in autism spectrum disorders: a CPEA Study.
abstract: In a multisite study of 351 children with autism spectrum disorders, 21 children with developmental delays, and 31 children with typical development, this study used caregiver interviews (i.e., the Autism Diagnostic Interview-Revised) at the time of entry into other research projects and follow-up telephone interviews designed for this project to describe the children's early acquisition and loss of social-communication milestones. Children who had used words spontaneously and meaningfully and then stopped talking were described by their caregivers as showing more gestures, greater participation in social games, and better receptive language before the loss and fewer of these skills after the loss than other children with autism spectrum disorders. A significant minority of children with autism without word loss showed a very similar pattern of loss of social-communication skills, a pattern not observed in the children with developmental delays or typical development.
authors.affiliation: Autism & Communication Disorders Center, University of Michigan, Ann Arbor 48109-2054, USA.
authors.forename: Rhiannon
authors.initials: R
authors.lastname: Luyster
authors.forename: Jennifer
authors.initials: J
authors.lastname: Richler
authors.forename: Susan
authors.initials: S
authors.lastname: Risi
authors.forename: Wan-Ling
authors.initials: WL
authors.lastname: Hsu
authors.forename: Geraldine
authors.initials: G
authors.lastname: Dawson
authors.forename: Raphael
authors.initials: R
authors.lastname: Bernier
authors.forename: Michelle
authors.initials: M
authors.lastname: Dunn
authors.forename: Susan
authors.initials: S
authors.lastname: Hepburn
authors.forename: Susan L
authors.initials: SL
authors.lastname: Hyman
authors.forename: William M
authors.initials: WM
authors.lastname: McMahon
authors.forename: Julie
authors.initials: J
authors.lastname: Goudie-Nice
authors.forename: Nancy
authors.initials: N
authors.lastname: Minshew
authors.forename: Sally
authors.initials: S
authors.lastname: Rogers
authors.forename: Marian
authors.initials: M
authors.lastname: Sigman
authors.forename: M Anne
authors.initials: MA
authors.lastname: Spence
authors.forename: Wendy A
authors.initials: WA
authors.lastname: Goldberg
authors.forename: Helen
authors.initials: H
authors.lastname: Tager-Flusberg
authors.forename: Fred R
authors.initials: FR
authors.lastname: Volkmar
authors.forename: Catherine
authors.initials: C
authors.lastname: Lord
mesh_terms: D000367:Age Factors; D001321:Autistic Disorder / Q000150:complications*; D002648:Child; D003147:Communication Disorders / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D012043:Regression, Psychology; D012720:Severity of Illness Index; D012919:Social Behavior