title: Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae.
abstract: A novel series of 6-O-arylpropargyl diazalides was synthesized and evaluated for their antibacterial activity. Members of this series exhibited potent activity against erythromycin-resistant respiratory tract pathogens.
authors.affiliation: Infectious Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60044, USA. hong.yong@abbott.com
authors.forename: Hong
authors.initials: H
authors.lastname: Yong
authors.forename: Yu Gui
authors.initials: YG
authors.lastname: Gu
authors.forename: Richard F
authors.initials: RF
authors.lastname: Clark
authors.forename: Thomas
authors.initials: T
authors.lastname: Marron
authors.forename: Zhenkun
authors.initials: Z
authors.lastname: Ma
authors.forename: Niru
authors.initials: N
authors.lastname: Soni
authors.forename: Gregory G
authors.initials: GG
authors.lastname: Stone
authors.forename: Angela M
authors.initials: AM
authors.lastname: Nilius
authors.forename: Kennan
authors.initials: K
authors.lastname: Marsh
authors.forename: Stevan W
authors.initials: SW
authors.lastname: Djuric
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D001682:Biological Availability; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D006207:Half-Life; D008826:Microbial Sensitivity Tests; D020005:Propanols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D013329:Structure-Activity Relationship; D015645:Tylosin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D020005:Propanols; D015645:Tylosin