title: [New targets for molecular therapy of acute leukemia: a "single-hit" or "multiple-hit" strategy against signaling pathway].
authors.forename: Guang-Sen
authors.initials: GS
authors.lastname: Zhang
mesh_terms: D000208:Acute Disease; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002227:Carbazoles / Q000627:therapeutic use; D005663:Furans; D006801:Humans; D007211:Indoles / Q000627:therapeutic use; D007938:Leukemia / Q000188:drug therapy*; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D009154:Mutation; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D015363:Quinolones / Q000627:therapeutic use*; D019311:Staurosporine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D018631:ras Proteins / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D002227:Carbazoles; D005663:Furans; D007211:Indoles; D015363:Quinolones; C119379:lestaurtinib; D011505:Protein-Tyrosine Kinases; D018631:ras Proteins; D019311:Staurosporine; C059539:midostaurin; C402769:tipifarnib