Intraventricular chordoid meningioma presenting with Castleman disease due to overproduction of interleukin-6. Case report.
A rare case of chordoid meningioma in the lateral ventricle observed in an adult is reported. The first clinical manifestation of the disease was a prolonged fever of unknown origin. Abnormalities in the patient's blood chemistry, principally polyclonal hypergammaglobulinemia (immunoglobulin [Ig]G, IgA, and markedly IgE) and an elevated serum level of C-reactive protein, were associated with the disease. The tumor was histologically confirmed to be a chordoid meningioma, and its surgical removal resulted in complete resolution of the patient's symptoms. By combining reverse transcription-polymerase chain reaction and immunohistochemical analysis, it may be shown that cytokine production, including that of interleukin (IL)-6, IL-1beta, and vascular endothelial growth factor, plays a role in the pathogenesis of chordoid meningioma associated with Castleman syndrome.
Arima
Toru
T
Department of Neurosurgery, Division of Pathology, Clinical Laboratory, Center for Genetic and Regenerative Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Natsume
Atsushi
A
Hatano
Hisashi
H
Nakahara
Norimoto
N
Fujita
Mitsugu
M
Ishii
Dai
D
Wakabayashi
Toshihiko
T
Doyu
Manabu
M
Nagasaka
Tetsuro
T
Yoshida
Jun
J
D000328:Adult; D005871:Castleman Disease / Q000209:etiology*; D002830:Choroid Neoplasms / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007375:Interleukin-1 / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis* / Q000097:blood; D020547:Lateral Ventricles / Q000473:pathology; D008577:Meningeal Neoplasms / Q000150:complications* / Q000175:diagnosis; D008579:Meningioma / Q000150:complications* / Q000175:diagnosis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis
D007375:Interleukin-1; D015850:Interleukin-6; D042461:Vascular Endothelial Growth Factor A