title: Investigation of beta-lactam antibiotic-induced vancomycin-resistant MRSA (BIVR).
abstract: We could not detect hetero-vancomycin-intermediate resistant Staphylococcus aureus (hetero-VISA), according to the definition of hetero-VISA, from the clinical isolates of 140 methicillin-resistant S. aureus (MRSA) strains. However, 15 beta-lactam antibiotic-induced vancomycin-resistant MRSA (BIVR) strains were detected from the same strains. We screened 1882 MRSA clinical isolates obtained in 2002 from 21 institutes throughout Japan. The detection rate of blood-isolated BIVR was 12.6% (19/151), and that of nonblood-isolated BIVR was 4.9% (85/1731; P < 0.001; chi2 test). Uridine-diphosphate-N-acetylmuramyl-L: -alanyl-D: -isoglutamyl-L: -lysine, used as the peptidoglycan material of S. aureus, showed the same results as beta-lactam antibiotics in BIVR.
authors.affiliation: Research Center for Anti-infective Drugs, The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-0072, Japan. hanaki@lisci.kitasato-u.ac.jp
authors.forename: Hideaki
authors.initials: H
authors.lastname: Hanaki
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Chie
authors.initials: C
authors.lastname: Yanagisawa
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Uehara
authors.forename: Hidehito
authors.initials: H
authors.lastname: Matsui
authors.forename: Yukie
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Hososaka
authors.forename: Kazunari
authors.initials: K
authors.lastname: Barada
authors.forename: Fumiko
authors.initials: F
authors.lastname: Sakai
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Itabashi
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Ikeda
authors.forename: Koichiro
authors.initials: K
authors.lastname: Atsuda
authors.forename: Haruo
authors.initials: H
authors.lastname: Tanaka
authors.forename: Takashi
authors.initials: T
authors.lastname: Inamatsu
authors.forename: Ariaki
authors.initials: A
authors.lastname: Nagayama
authors.forename: Keisuke
authors.initials: K
authors.lastname: Sunakawa
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects*; D020713:Vancomycin Resistance; D047090:beta-Lactams / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams