title: Iso-, nor-, and dinor-spiculoic acids A, polyketides from the marine sponge Plakortis zyggompha.
abstract: The new iso-, nor-, and dinor-spiculoic acids A (1, 2, and 3, respectively) with a rare spiculane skeleton were isolated from the marine sponge Plakortis zyggompha, collected in the waters south of Martinique. The structural determination of the compounds was based on 1D and 2D NMR studies and mass spectral determinations. Compounds 1 and 2 showed weak cytotoxicity against the two tumor cell lines A549 and HT29.
authors.affiliation: Laboratoire de Chimie Bioorganique, UMR 6001 CNRS, Faculté des Science, UNSA, Parc Valrose, 06108 Nice Cedex 02, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Berrué
authors.forename: Olivier P
authors.initials: OP
authors.lastname: Thomas
authors.forename: Rogelio
authors.initials: R
authors.lastname: Fernández
authors.forename: Philippe
authors.initials: P
authors.lastname: Amade
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002264:Carboxylic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D007189:Indans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D047229:Plakortis / Q000737:chemistry*; D013030:Spain; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D002264:Carboxylic Acids; D007189:Indans; C500767:dinor-spiculoic acid A; C500765:iso-spiculoic acid A; C500766:nor-spiculoic acid A