The genome sequence of the rice blast fungus Magnaporthe grisea.
Magnaporthe grisea is the most destructive pathogen of rice worldwide and the principal model organism for elucidating the molecular basis of fungal disease of plants. Here, we report the draft sequence of the M. grisea genome. Analysis of the gene set provides an insight into the adaptations required by a fungus to cause disease. The genome encodes a large and diverse set of secreted proteins, including those defined by unusual carbohydrate-binding domains. This fungus also possesses an expanded family of G-protein-coupled receptors, several new virulence-associated genes and large suites of enzymes involved in secondary metabolism. Consistent with a role in fungal pathogenesis, the expression of several of these genes is upregulated during the early stages of infection-related development. The M. grisea genome has been subject to invasion and proliferation of active transposable elements, reflecting the clonal nature of this fungus imposed by widespread rice cultivation.
Dean
Ralph A
RA
Center for Integrated Fungal Research, North Carolina State University, Raleigh, North Carolina 27695, USA. Ralph_Dean@ncsu.edu
Talbot
Nicholas J
NJ
Ebbole
Daniel J
DJ
Farman
Mark L
ML
Mitchell
Thomas K
TK
Orbach
Marc J
MJ
Thon
Michael
M
Kulkarni
Resham
R
Xu
Jin-Rong
JR
Pan
Huaqin
H
Read
Nick D
ND
Lee
Yong-Hwan
YH
Carbone
Ignazio
I
Brown
Doug
D
Oh
Yeon Yee
YY
Donofrio
Nicole
N
Jeong
Jun Seop
JS
Soanes
Darren M
DM
Djonovic
Slavica
S
Kolomiets
Elena
E
Rehmeyer
Cathryn
C
Li
Weixi
W
Harding
Michael
M
Kim
Soonok
S
Lebrun
Marc-Henri
MH
Bohnert
Heidi
H
Coughlan
Sean
S
Butler
Jonathan
J
Calvo
Sarah
S
Ma
Li-Jun
LJ
Nicol
Robert
R
Purcell
Seth
S
Nusbaum
Chad
C
Galagan
James E
JE
Birren
Bruce W
BW
D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D005800:Genes, Fungal / Q000235:genetics; D016681:Genome, Fungal; D006153:Guanosine Diphosphate / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000378:metabolism; D020082:Magnaporthe / Q000145:classification / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity; D012275:Oryza / Q000382:microbiology*; D010935:Plant Diseases / Q000382:microbiology; D017354:Point Mutation / Q000235:genetics; D020543:Proteome / Q000235:genetics / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D015398:Signal Transduction; D014774:Virulence / Q000235:genetics
D005656:Fungal Proteins; D020543:Proteome; D043562:Receptors, G-Protein-Coupled; D006153:Guanosine Diphosphate; D006160:Guanosine Triphosphate