title: Effect of topical applications of a chlorhexidine/thymol-containing varnish on fissure caries assessed by laser fluorescence.
abstract: The aim of this study was to monitor the effect of an antibacterial varnish using the readings of a caries-detecting device (DIAGNOdent) in fissures of young permanent molars. The material consisted of 32 healthy patients with a mean age of 14.1 years undergoing orthodontic treatment with fixed appliances. The inclusion criteria were presence of one homologous pair of 2nd upper or lower molars with clinically intact occlusal surfaces. A split-mouth study design was used in which the fissures were treated with either an antibacterial chlorhexidine/thymol-containing varnish or a placebo varnish every 6th week. The follow-up period was 42 weeks and laser fluorescence (LF) readings were carried out every 12th week. The mean LF values increased significantly (P < 0.05) after 24, 36, and 48 weeks compared to baseline following the placebo treatments but not after treatment with the active antibacterial varnish. During the study period, micro-cavities were diagnosed in two test-treated and five placebo-treated teeth. In conclusion, the results reinforce previous findings that frequent applications of a chlorhexidine/thymol-containing dental varnish might have a protective role in fissures of young permanent molars and that this could be monitored with a chair-side caries detecting LF device.
authors.affiliation: Department of Orthodontics, Maxillofacial Unit, County Hospital, Halmstad, Sweden.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Sköld-Larsson
authors.forename: Ann-Charlott
authors.initials: AC
authors.lastname: Fornell
authors.forename: Adrian
authors.initials: A
authors.lastname: Lussi
authors.forename: Svante
authors.initials: S
authors.lastname: Twetman
mesh_terms: D000293:Adolescent; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002327:Cariostatic Agents / Q000627:therapeutic use*; D002648:Child; D002710:Chlorhexidine / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D004245:DMF Index; D003732:Dental Caries Activity Tests; D003750:Dental Fissures / Q000175:diagnosis / Q000517:prevention & control*; D004338:Drug Combinations; D005260:Female; D005453:Fluorescence; D006801:Humans; D007834:Lasers; D008297:Male; D008963:Molar; D016017:Odds Ratio; D012044:Regression Analysis; D012463:Saliva / Q000382:microbiology; D018709:Statistics, Nonparametric; D013295:Streptococcus mutans / Q000302:isolation & purification; D013943:Thymol / Q000627:therapeutic use*
chemical_list: D000891:Anti-Infective Agents, Local; D002327:Cariostatic Agents; D004338:Drug Combinations; C079161:chlorhexidine, thymol drug combination; D013943:Thymol; D002710:Chlorhexidine