Cognitive function and cerebral assessment in patients who have Cushing's syndrome.
Cushing's syndrome (CS) is a relevant model to better understand the effects of glucocorticoid (GC) excess on the human brain. The importance of GC excess on the central nervous system is highlighted by the high prevalence of neuropsychiatric disorders such as depression and cognitive impairment in patients who have CS. In addition, there is a high incidence of apparent diffuse loss of brain volume in patients who have CS. Recent studies indicate at least partial reversibility of these abnormalities following correction of hypercortisolism.
Bourdeau
Isabelle
I
Division of Endocrinology, Department of Medicine, Hôtel-Dieu du Centre Hospitalier de l'Université de Montréal, 3840 Saint-Urbain Street, Montreal, Quebec H2W 1T8, Canada. isabelle.bourdeau@umontreal.ca
Bard
Céline
C
Forget
Hélène
H
Boulanger
Yvan
Y
Cohen
Henri
H
Lacroix
André
A
D003071:Cognition; D003072:Cognition Disorders / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology; D003480:Cushing Syndrome / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging