title: Activities of antioxidant enzymes in two stages of pathology development in sucrose-fed rats.
abstract: The activities of catalase in liver, heart and kidney as well as glutathione peroxidase and superoxide dismutase in liver, heart, kidney, and serum from hypertriglyceridemic and hypertensive female and male rats were measured at 3 and 8 months of daily administration of sucrose in their drinking water. This treatment induces high levels of serum triglycerides, central obesity, moderate hypertension, hyperinsulinemia, and an increase in lipoperoxidation, among other alterations. The experimental periods were chosen on the basis of previous observations: at 3 months the level of serum triglycerides increases significantly above the normal value and remains without major changes thereafter, but the blood pressure only rises significantly at about 4 months in males and 5 months in females. So, at 8 months the rats have been subjected to abnormal conditions for 3-4 months. The effect of these and the influence of sex on levels of antioxidant enzymes were investigated. Both factors, sucrose treatment and sex, were conducive to significant changes in those variables.
authors.affiliation: Departamento de Bioquímica, INCICh, México. gbanos@yahoo.com
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Baños
authors.forename: Omar N
authors.initials: ON
authors.lastname: Medina-Campos
authors.forename: Perla D
authors.initials: PD
authors.lastname: Maldonado
authors.forename: José
authors.initials: J
authors.lastname: Zamora
authors.forename: Israel
authors.initials: I
authors.lastname: Pérez
authors.forename: Natalia
authors.initials: N
authors.lastname: Pavón
authors.forename: José
authors.initials: J
authors.lastname: Pedraza-Chaverrí
mesh_terms: D000367:Age Factors; D000818:Animals; D002374:Catalase / Q000378:metabolism*; D019422:Dietary Sucrose / Q000008:administration & dosage*; D004195:Disease Models, Animal; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood / Q000378:metabolism*; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism*; D015228:Hypertriglyceridemia / Q000139:chemically induced / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D024821:Metabolic Syndrome / Q000139:chemically induced / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D051381:Rats; D012737:Sex Factors; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism*; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D019422:Dietary Sucrose; D014280:Triglycerides; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase