title: Thyrotoxicosis caused by weight-reducing herbal medicines.
abstract: The weight-reducing herbal medicines "Dream Shape" and "Ever Youth" became available in Japan in 2000. Herein, we describe 12 patients who developed thyrotoxicosis after taking them. The thyroid hormone content of 1 capsule or tablet of herbal medicine, measured following Pronase digestion and ethanol extraction, was approximately 1 mug of triiodothyronine and 3 to 4 mug of thyroxine. Two of us took 10 capsules or tablets of Dream Shape or Ever Youth, and changes in thyroid hormone levels were observed during the first 24 hours. Serum free triiodothyronine levels began to rise 2 hours after ingestion and reached peak levels at 4 to 8 hours; changes in free thyroxine and thyrotropin levels were small during the first 24 hours. Similar herbal medicines may have been distributed to other countries via the Internet. Resultant factitious thyrotoxicosis can create diagnostic and therapeutic confusion, particularly in patients with thyroid disease.
authors.affiliation: Kuma Hospital, 8-2-35, Shimoyamate-dori, Chuou-ku, Kobe, Hyogo, Japan 650-0011. ohye@kuma-h.or.jp
authors.forename: Hidemi
authors.initials: H
authors.lastname: Ohye
authors.forename: Shuji
authors.initials: S
authors.lastname: Fukata
authors.forename: Maki
authors.initials: M
authors.lastname: Kanoh
authors.forename: Sumihisa
authors.initials: S
authors.lastname: Kubota
authors.forename: Kanji
authors.initials: K
authors.lastname: Kuma
authors.forename: Akira
authors.initials: A
authors.lastname: Miyauchi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sugawara
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D028321:Plant Preparations / Q000008:administration & dosage / Q000009:adverse effects*; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism; D013963:Thyroid Hormones / Q000097:blood; D013971:Thyrotoxicosis / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis; D013972:Thyrotropin / Q000097:blood; D015431:Weight Loss / Q000187:drug effects*
chemical_list: D028321:Plant Preparations; D013963:Thyroid Hormones; D013972:Thyrotropin