[Investigation of local reaction of muscular tissue after injection of polyvinylpyrrolidone preparation].
Natural preparations for replenishing of hyaluronic acid of zoogenous origin used till now, are characterized with quit low biocompatibility and also too short effect of their action. Recently worked out synthetic polyvinylpyrrolidone preparation PVP, contains modification constituting internally netting of microgels to improve polymer bioresistance. The introduce modification can, however influence PVP biocompatibility after deposition into tissues of the living organism. The aim of research was evaluation of the local reaction of muscular tissue after PVP infection. The results of research concerned a control group where normal saline was used for infections. The research was carried out on 18 Wistar rats and included macroscopic and histologic observations made in the 3rd, 5th, 7th, 14th and 30th day after PVP injection into thigh muscle. The local reaction of muscular tissue was macroscopically characterized with inflammatory reaction till the 7th day after PVP injection, in later terms the observed changes disappeared. Microscopic research showed that PVP till the 7th day after PVP injection caused rather strong diffuse non-specific inflammatory process, yet without essential participation of neutrophils leading to producing of loose intra-muscular. Connective tissue in a later term. The carried out tests showed presence of PVP in muscular tissue till the 30th day after injection.
Pielka
Stanisław
S
Zakład Chirurgii Eksperymentalnej i Badania Biomateriałów Akademii Medycznej we Wrocławiu. implant@cheksp.am.wroc.pl
Zywicka
Bogusława
B
Rosiak
Janusz
J
Henke
Artur
A
Ulański
Piotr
P
Paluch
Danuta
D
Szymonowicz
Maria
M
Solski
Leszek
L
Staniszewska-Kuś
Jolanta
J
D000818:Animals; D001672:Biocompatible Materials; D005260:Female; D005549:Foreign-Body Reaction; D007273:Injections, Intramuscular; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000473:pathology*; D011205:Povidone / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D001672:Biocompatible Materials; D011205:Povidone