title: Clear cell hidradenoma: a mimic of metastatic clear cell tumors.
abstract: Clear cell hidradenoma is a benign skin appendage tumor that may mimic conventional-type renal cell carcinoma. Histologically, clear cell hidradenoma contains small ductular lumens, focal apocrine and squamoid change, and a less prominent vascular pattern than renal cell carcinoma. Furthermore, immunohistochemical studies can aid in distinguishing the 2 tumors. Knowing the cytologic features of primary skin adnexal neoplasms helps distinguish them from cutaneous metastases, which are more commonly referred for fine-needle aspiration biopsy evaluation. Detailed clinical history, physical findings, and ancillary studies are essential for correct diagnosis and categorization of these tumors. We report the rare case of a patient with renal cell carcinoma who underwent excision of an axillary clear cell hidradenoma, which was clinically suggestive of cutaneous metastatic disease.
authors.affiliation: Department of Pathology, Duke University Medical Center, Durham, NC 27599, USA. kevolmar@yahoo.com
authors.forename: Keith E
authors.initials: KE
authors.lastname: Volmar
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Cummings
authors.forename: Wei Hua
authors.initials: WH
authors.lastname: Wang
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Creager
authors.forename: Douglas S
authors.initials: DS
authors.lastname: Tyler
authors.forename: H Bill
authors.initials: HB
authors.lastname: Xie
mesh_terms: D006607:Adenoma, Sweat Gland / Q000737:chemistry / Q000175:diagnosis* / Q000601:surgery; D001365:Axilla; D014408:Biomarkers, Tumor / Q000032:analysis; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000556:secondary / Q000601:surgery; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000601:surgery; D008198:Lymph Nodes / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D008940:Mitotic Index; D009362:Neoplasm Metastasis / Q000175:diagnosis; D009378:Neoplasms, Multiple Primary / Q000737:chemistry / Q000175:diagnosis* / Q000601:surgery; D013544:Sweat Gland Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor