title: [Effects of acute hypoxia on expression of heat shock protein 70 in cochlea of guinea pigs].
abstract: OBJECTIVE
  To investigate the changes of the expression of heat shock protein 70 (HSP70) in the cochlea of guinea pigs under acute hypoxia.
  
  
  METHODS
  Different degrees of acute hypoxia were imposed on guinea pigs and slices of the cochlea were examined by immunohistochemistry to detect HSP70.
  
  
  RESULTS
  In normal situation, HSP70 is expressed in guinea pig's cochlea, especially in spiral ganglion and Corti's organ, under acute hypoxia, this expression was strengthened, and the degree of this strengthening showed no correlation with degree of hypoxia.
  
  
  CONCLUSIONS
  These results suggest that acute hypoxia can strengthen the expression of HSP70 in guinea pig's cochlea, and the degree of hypoxia has no effects on the degree of this strengthening. The expression of HSP70 in the cochlea may be a kind of protection to the structure and the function of the inner ear.
authors.affiliation: Department of Otolarygology, The 306th Hospital of PLA, Beijing, China. whn95@yahoo.com
authors.forename: Hong-nan
authors.initials: HN
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.forename: Xi-jun
authors.initials: XJ
authors.lastname: Wang
authors.forename: Jiang-shun
authors.initials: JS
authors.lastname: Song
mesh_terms: D000818:Animals; D003051:Cochlea / Q000378:metabolism*; D015870:Gene Expression; D006168:Guinea Pigs; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis* / Q000235:genetics; D000860:Hypoxia; D051381:Rats; D013136:Spiral Ganglion / Q000378:metabolism
chemical_list: D018840:HSP70 Heat-Shock Proteins