title: Outcomes of adult cadaveric renal transplantation in ireland 1986 to 2001.
abstract: BACKGROUND
  Since the introduction of renal transplantation in the Republic of Ireland in 1964, the number of transplants performed annually has increased from single figures in the 1960s to the current rate of approximately 130 renal transplants per year. Improvements in graft and patient outcomes have been associated with the introduction of the immunosuppressive agent Cyclosporin (CSA) in the mid 1980s.
  
  
  OBJECTIVE
  The aim of this study was to examine trends in outcomes and factors that influence outcomes for adult kidney transplantation from 1986 to 2001.
  
  
  METHODS
  All adult cadaveric kidney transplantations carried out between 1986 and 2001 were included. We separated the transplanted grafts and patients into four time periods; 1986-1989, 1990-1993, 1994-1997, 1998-2001. Graft and patient survival outcomes were compared for the different periods.
  
  
  RESULTS
  The one-year kidney graft survival rate increased from 82% during 1986-1989 to 86% during 1998-2001. Patient survival over the four time periods studied has remained stable at approximately 95% at one year.
  
  
  CONCLUSIONS
  We report a significant improvement in kidney graft outcomes over the past 16 years. Patient survival has remained relatively stable during this period.
authors.affiliation: Departments of Nephrology' and Renal Transplantation, Beaumont Hospital, Dublin, Ireland.
authors.forename: P
authors.initials: P
authors.lastname: O'Kelly
authors.forename: L
authors.initials: L
authors.lastname: Giblin
authors.forename: S
authors.initials: S
authors.lastname: Spencer
authors.forename: J
authors.initials: J
authors.lastname: Donohoe
authors.forename: J J
authors.initials: JJ
authors.lastname: Walshe
authors.forename: D M
authors.initials: DM
authors.lastname: Little
authors.forename: D
authors.initials: D
authors.lastname: Hickey
authors.forename: P
authors.initials: P
authors.lastname: Cunningham
authors.forename: P J
authors.initials: PJ
authors.lastname: Conlon
mesh_terms: D000328:Adult; D002102:Cadaver; D016572:Cyclosporine / Q000627:therapeutic use; D005260:Female; D006650:Histocompatibility Testing; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007494:Ireland / Q000453:epidemiology; D016030:Kidney Transplantation / Q000276:immunology / Q000401:mortality* / Q000706:statistics & numerical data; D008297:Male; D011182:Postoperative Care; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine