Vitamins deficiency in developing chick during chromium intoxication and protection thereof.
Deficiency of various vitamins in postnatally developing chick during chromium intoxication and their recovery during vitamins (B and E) and glutathione therapies has been investigated. Study was concentrated on liver, kidney, muscles and serum. Newly hatched chicks were reared in laboratory. They were treated with a daily dose of 10mg/kg/day potassium dichromate from 2nd to 8th day of their age. Thereafter, one group was sacrificed on 9th day. Second group was kept without intoxication for another 7 days and sacrificed on 16th day. Three groups of chromium pretoxicated animals were exposed to therapeutic agents like vitamins (B and E) and glutathione for another 7 days. These animals were sacrificed on 16th day of their age along with control. Study showed chromium intoxication decreases vitamins (B(1), B(2), B(6) and E) in all the tissues and serum. The maximum decrease was recorded in serum. The 7 days pretoxicated animals kept without any treatment for 7 days revealed a slow increase of vitamins with few exceptions. Nevertheless, the recovery of vitamins was quick and significant during vitamins and glutathione therapy and in some cases control level was achieved.
Chundawat
Rajendra Singh
RS
Laboratory of Neurobiology and Toxicology, Department of Biosciences, Saurashtra University, Rajkot, Gujarat 360 005, India.
Sood
Prem Prakash
PP
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001361:Avitaminosis / Q000139:chemically induced*; D002645:Chickens / Q000502:physiology*; D002857:Chromium / Q000633:toxicity; D017608:Chromium Compounds / Q000633:toxicity*; D005978:Glutathione / Q000378:metabolism / Q000627:therapeutic use; D013831:Thiamine / Q000378:metabolism / Q000627:therapeutic use; D014018:Tissue Distribution; D025101:Vitamin B 6 / Q000378:metabolism / Q000627:therapeutic use; D014803:Vitamin B Complex / Q000378:metabolism / Q000627:therapeutic use; D014810:Vitamin E / Q000378:metabolism / Q000627:therapeutic use; D014815:Vitamins / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use
D017608:Chromium Compounds; D014815:Vitamins; D002857:Chromium; D014803:Vitamin B Complex; D014810:Vitamin E; C074702:chromium hexavalent ion; D025101:Vitamin B 6; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione; D013831:Thiamine