NF-kB in development and progression of human cancer.
The nuclear factor kB (NF-kB) comprises a family of transcription factors involved in the regulation of a wide variety of biological responses. NF-kB plays a well-known function in the regulation of immune responses and inflammation, but growing evidences support a major role in oncogenesis. NF-kB regulates the expression of genes involved in many processes that play a key role in the development and progression of cancer such as proliferation, migration and apoptosis. Aberrant or constitutive NF-kB activation has been detected in many human malignancies. In recent years, numerous studies have focused on elucidating the functional consequences of NF-kB activation as well as its signaling mechanisms. NF-kB has turned out to be an interesting therapeutic target for treatment of cancer.
Dolcet
Xavier
X
Department of Pathology and Molecular Genetics, Hospital Universitari Arnau de Vilanova, University of Lleida, Av Alcalde Rovira Roure 80, 25198, Lleida, Spain.
Llobet
David
D
Pallares
Judit
J
Matias-Guiu
Xavier
X
D017209:Apoptosis; D002455:Cell Division; D019008:Drug Resistance, Neoplasm; D006801:Humans; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000502:physiology*; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D015398:Signal Transduction
D016328:NF-kappa B