3,3-Bisaryloxindoles as mineralocorticoid receptor antagonists.
Syntheses and SAR studies of 3,3-bisaryloxindole analogues provided potent mineralocorticoid receptor (MR) antagonists that were selective over other steroid nuclear hormone receptors.
Neel
David A
DA
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA. neel_david_a@lilly.com
Brown
Matthew L
ML
Lander
Peter A
PA
Grese
Timothy A
TA
Defauw
Jean M
JM
Doti
Robert A
RA
Fields
Todd
T
Kelley
Sally Ann
SA
Smith
Stephon
S
Zimmerman
Karen M
KM
Steinberg
Mitchell I
MI
Jadhav
Prabhakar K
PK
D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D000451:Mineralocorticoid Receptor Antagonists; D011869:Radioligand Assay
D007211:Indoles; D000451:Mineralocorticoid Receptor Antagonists