title: Uses of topiramate in the treatment of alcohol dependence.
abstract: Alcohol dependence is a major cause of morbidity and mortality in the USA and throughout the world. Over the last 10 years there has been an intense interest in developing pharmacotherapies that address the neurochemistry of alcohol dependence. Using a novel pharmacological approach to treating alcohol dependence, topiramate (Topamax, Ortho-McNeil Pharmaceutical) has recently been shown to improve the drinking outcomes of alcohol-dependent individuals. This drug profile highlights the scientific concepts and clinical evidence in the development of topiramate for treating alcohol dependence.
authors.affiliation: Division of Alcohol and Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 3939 Medical Drive, Suite 100, San Antonio, TX 78229 3900, USA. bjohnson@uthscsa.edu
authors.forename: Bankole A
authors.initials: BA
authors.lastname: Johnson
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000188:drug therapy; D019973:Alcohol-Related Disorders / Q000097:blood / Q000188:drug therapy* / Q000453:epidemiology; D002986:Clinical Trials as Topic; D016001:Confidence Intervals; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives* / Q000097:blood / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D018696:Neuroprotective Agents / Q000097:blood / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D011336:Probability; D013997:Time Factors; D000077236:Topiramate; D016896:Treatment Outcome; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D018696:Neuroprotective Agents; D000077236:Topiramate; D005632:Fructose; D005723:gamma-Glutamyltransferase