title: [Effects of landiolol hydrochloride on cardiohemodynamics in patients who underwent coronary artery bypass grafting].
abstract: BACKGROUND
  It is important to control heart rate for coronary artery bypass grafting. The purpose of this study was to evaluate the effects of landiolol hydrochloride, ultra-short-acting beta-blocker, on cardiohemodynamics in 10 patients who underwent coronary artery bypass grafting.
  
  
  METHODS
  Anesthesia was induced and maintained with midazolam and fentanyl. After stabilization of anesthesia, landiolol hydrochloride was administered at a rate of 0.04 mg x kg(-1) x min(-1) for 30 min after 0.125 mg x kg(-1) x min(-1). Hemodynamic measurements were made before and every 5 min after administration of landiolol hydrochloride.
  
  
  RESULTS
  Heart rate decreased significantly although arterial pressure was unchanged. There were no changes in cardiac index, left ventricular stroke volume index, systemic vascular resistances and pulmonary vascular resistance after landiolol hydrochloride administration.
  
  
  CONCLUSIONS
  These results suggest that landiolol hydrochloride possesses less negative inotropic action than negative chronotropic action. Landiolol hydrochloride did not affect both systemic and pulmonary vascular resistances because of high cardioselectivity.
authors.affiliation: Department of Anesthesiology, Nagano Red-Cross Hospital, Nagano.
authors.forename: Ken
authors.initials: K
authors.lastname: Iwasawa
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Nakagawa
authors.forename: Mikiyoshi
authors.initials: M
authors.lastname: Katou
authors.forename: Kaori
authors.initials: K
authors.lastname: Yonezawa
authors.forename: Masaaki
authors.initials: M
authors.lastname: Nishizawa
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Yanagiya
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002496:Central Venous Pressure / Q000187:drug effects; D001026:Coronary Artery Bypass; D003864:Depression, Chemical; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009025:Morpholines / Q000494:pharmacology*; D014508:Urea / Q000031:analogs & derivatives* / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D000319:Adrenergic beta-Antagonists; D009025:Morpholines; C077049:landiolol; D014508:Urea