title: Lignans from Acanthopanax chiisanensis having an inhibitory activity on prostaglandin E2 production.
abstract: The chloroform and the ethyl acetate fractions from the roots of Acanthopanax chiisanensis exhibited the significant inhibition of TPA-induced prostaglandin E(2) (PGE(2)) production in rat peritoneal macrophages. Five lignans were isolated from the chloroform fraction and their structures were elucidated as l-sesamin, helioxanthin, savinin, taiwanin C, and 3-(3,4-dimethoxybenzyl)-2-(3,4-methylenedioxybenzyl)butyrolactone. Among the lignans tested, taiwanin C showed the most potent inhibitory activity (IC(50) = 0.12 microM) on PGE(2) production with the relative order of potency, taiwanin C >> 3-(3,4-dimethoxybenzyl)-2-(3,4-methylenedioxybenzyl)butyrolactone > savinin = helioxanthin. l-Sesamin showed no inhibitory activity at 30 microM.
authors.affiliation: Natural Products Research Institute, Seoul National University, Korea.
authors.forename: Sanghyun
authors.initials: S
authors.lastname: Lee
authors.forename: Hyun Seung
authors.initials: HS
authors.lastname: Ban
authors.forename: Yong Pil
authors.initials: YP
authors.lastname: Kim
authors.forename: Bak-Kwang
authors.initials: BK
authors.lastname: Kim
authors.forename: Seon Haeng
authors.initials: SH
authors.lastname: Cho
authors.forename: Kazuo
authors.initials: K
authors.lastname: Ohuchi
authors.forename: Kuk Hyun
authors.initials: KH
authors.lastname: Shin
mesh_terms: D000818:Animals; D015232:Dinoprostone / Q000378:metabolism*; D028001:Eleutherococcus; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D017705:Lignans / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D017737:Macrophages, Peritoneal / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004791:Enzyme Inhibitors; D017705:Lignans; D010936:Plant Extracts; D015232:Dinoprostone