Health effects classification and its role in the derivation of minimal risk levels: hepatic effects.
The Agency for Toxic Substances and Disease Registry (ATSDR) derives health based guidance values called minimal risk levels (MRLs) to assist with assessment of risks posed by exposures to hazardous chemicals. Current MRLs are posted on ATSDR's web site (www.atsdr.cdc.gov). From the total 326 MRLs currently posted, 79 MRLs are based on hepatic endpoints. The paper reports on endpoints used for the derivation of these MRLs and the use of uncertainty factors. It also describes the ranking of effects into less serious and serious categories as described in ATSDR's Guidance for Developing Toxicological Profiles.
Pohl
Hana R
HR
Agency for Toxic Substances and Disease Registry, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA. hpohl@cdc.gov
Chou
C-H Selene J
CH
D000818:Animals; D001659:Biliary Tract / Q000187:drug effects / Q000473:pathology; D017408:Guidelines as Topic; D015386:Hazardous Substances / Q000008:administration & dosage / Q000145:classification / Q000633:toxicity; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D019055:No-Observed-Adverse-Effect Level; D009929:Organ Size / Q000187:drug effects; D012720:Severity of Illness Index; D018675:Toxicity Tests / Q000379:methods / Q000592:standards; D014481:United States; D014492:United States Public Health Service
D015386:Hazardous Substances