title: [Serum IL-2 and sIL-2R concentration in children with chronic hepatitis B].
abstract: The aim of the study was evaluation of serum IL-2 and sIL-2R concentration in children with chronic hepatitis B without previous treatment.
  
  
  METHODS
  Investigations were performed on sera from 27 children, 13 HBsAg and HBeAg positive (group I) and 14 HBsAg positive, HBeAg negative, anti-HBe positive (group II). Serum IL-2 and sIL-2R concentrations were detected with ELISA method.
  
  
  RESULTS
  In all examined children serum IL-2 concentrations were decreased. The mean values of sIL-2R in group I was 4,40 (from 1,78 to 15,74) and in group II was 2,60 ( from 1,59 to 4,81) ng/ ml and were statistically significant higher in HBeAg positive children (group I, p < 0.005). The mean ALT activity in this group of children was increased (mean 74 U/I) . The positive correlation between sIL-2R and ALT activity was observed in group I.
  
  
  CONCLUSIONS
  In children with chronic hepatitis B a deficiency of Th1 mediated immunological response was observed. HBeAg/anti-HBe seroconversion seems to change the IL-2/sIL-2R balance.
authors.affiliation: Katedra i Klinika Chorób Zakaźnych Akademii Medycznej w Bydgoszczy. kikchzak@amb.bydgoszcz.pl
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Pawłowska
authors.forename: Waldemar
authors.initials: W
authors.lastname: Halota
authors.forename: Ewa
authors.initials: E
authors.lastname: Smukalska
authors.forename: Edyta
authors.initials: E
authors.lastname: Grabczewska
mesh_terms: D000293:Adolescent; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006513:Hepatitis B e Antigens / Q000097:blood; D019694:Hepatitis B, Chronic / Q000097:blood*; D006801:Humans; D007376:Interleukin-2 / Q000097:blood*; D008297:Male; D015375:Receptors, Interleukin-2 / Q000097:blood*
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D007376:Interleukin-2; D015375:Receptors, Interleukin-2