title: [Detection of lymphoproliferative response in monkeys innoculated with dengue 4 virus].
abstract: A group of 6 Cynomolgus monkeys was immunized with dengue 4 virus (H247 standard strain). 60 days after innoculation the cellular proliferation against the same serotype as well as against hetereologous serotypes 1 and 2 was measured. A proliferative response predominantly of the specific serotype and some cross reactivity were detected. These results showed a behavior of primates similar in some extent to that of human beings and mice regarding the specific serotype and cross serotype response to dengue virus.
authors.affiliation: Instituto de Medicina Tropical "Pedro Kouni", Autopista Novia del Mediodía, km 6 1/2 La Lisa, Apartado Postal 601. Marianao 13, Ciudad de La Habana, Cuba. ciipk@ipk.sld.cu
authors.forename: Gissel
authors.initials: G
authors.lastname: García
authors.forename: Mailing
authors.initials: M
authors.lastname: Alvarez
authors.forename: Elaine
authors.initials: E
authors.lastname: Santana
authors.forename: José Rafael
authors.initials: JR
authors.lastname: Martínez
authors.forename: Alejandro
authors.initials: A
authors.lastname: Alvarez
authors.forename: Rosmary
authors.initials: R
authors.lastname: Rodríguez
authors.forename: María G
authors.initials: MG
authors.lastname: Guzmán
mesh_terms: D000818:Animals; D003715:Dengue / Q000276:immunology*; D003716:Dengue Virus / Q000145:classification / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D008252:Macaca fascicularis; D012703:Serotyping