Association between the ACE I/D gene polymorphism and physical performance in a homogeneous non-elite cohort.
BACKGROUND
I/D polymorphism of the ACE gene may be associated with better endurance performance and a stronger response to exercise training. The aim of this study was to investigate the association between ACE gene polymorphism and athletic performance in a homogeneous cohort.


METHODS
Eighty-eight male non-elite Caucasian Turkish athletes with similar training backgrounds for at least for 6 months were studied for ACE gene polymorphisms by PCR analysis. Performance on the 60-meter sprint and middle-distance running tests were evaluated.


RESULTS
The distributions of the ACE I/D genotypes were 20.5%, 40.9%, and 38.6% for II, ID, and DD polymorphisms in the whole group (N = 88), respectively. The ACE DD genotype frequency was significantly higher in the superior group (56.7%) than in the poor (37.9%) and mediocre (20.7%) group in middle-distance running performance (chi2 = 11.778; p = 0.019).


CONCLUSIONS
The ACE DD genotype may be related to better short-duration aerobic endurance performance. Larger homogeneous cohorts may help clarify the association between ACE I/D polymorphism and physical performance.
Cam
F Sirri
FS
Faculty of Medicine, Dept. of Medical Biology and Genetics, Celal Bayar University, Manisa, Turkey.
Colakoglu
Muzaffer
M
Sekuri
Cevad
C
Colakoglu
Sule
S
Sahan
Cagatay
C
Berdeli
Afig
A
D000483:Alleles; D015308:Anaerobic Threshold / Q000502:physiology; D015331:Cohort Studies; D004251:DNA Transposable Elements / Q000235:genetics; D017353:Gene Deletion; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D010807:Physical Endurance / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012420:Running / Q000502:physiology*; D014891:Weight Lifting / Q000502:physiology
D004251:DNA Transposable Elements; D007703:Peptidyl-Dipeptidase A