title: Effects of venlafaxine treatment on clozapine plasma levels in schizophrenic patients.
abstract: Depressive symptoms are found at any stage of schizophrenia, and antidepressant medication may be beneficial. Selective serotonin reuptake inhibitor antidepressants have been considered safe in schizophrenia but in combination with clozapine, that is widely used in chronic treatment-resistant schizophrenia, remarkable pharmacokinetic interactions can occur causing an elevation in clozapine plasma levels. To investigate this further, the plasma levels of clozapine were measured in 11 schizophrenic male patients with depressive symptoms who were administered both clozapine and venlafaxine. Low to moderate doses of venlafaxine did not seem to have any significant effect on clozapine plasma levels.
authors.affiliation: Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, FI-70240 Kuopio, Finland.
authors.forename: Eila
authors.initials: E
authors.lastname: Repo-Tiihonen
authors.forename: Anne
authors.initials: A
authors.lastname: Eloranta
authors.forename: Tero
authors.initials: T
authors.lastname: Hallikainen
authors.forename: Jari
authors.initials: J
authors.lastname: Tiihonen
mesh_terms: D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000097:blood* / Q000627:therapeutic use; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003024:Clozapine / Q000097:blood* / Q000627:therapeutic use; D003511:Cyclohexanols / Q000494:pharmacology* / Q000627:therapeutic use; D003863:Depression / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D000069470:Venlafaxine Hydrochloride
chemical_list: D018687:Antidepressive Agents, Second-Generation; D014150:Antipsychotic Agents; D003511:Cyclohexanols; D000069470:Venlafaxine Hydrochloride; D003024:Clozapine