Diabetes insipidus in the third trimester of pregnancy.
BACKGROUND
Transient diabetes insipidus may rarely present during late pregnancy and/or the immediate puerperium, and if unrecognized, may cause neurologic injury and threaten the lives of mother and fetus. However, when recognized early and treatment is initiated with desmopressin acetate, an analog of vasopressin that is resistant to vasopressinase, water loss in the urine is eliminated and complications may be abrogated. This report aims to increase the awareness of this disorder and describes appropriate treatment.


METHODS
Two cases of diabetes insipidus, believed to be due to excess vasopressinase, are presented to demonstrate the clinical features, pathogenesis, and treatment of this syndrome.


CONCLUSIONS
Awareness of the syndrome of transient diabetes insipidus may lead to early diagnosis and appropriate treatment that will reduce the risks of maternal and fetal morbidity.
Brewster
Ursula C
UC
Section of Nephrology, Yale University School of Medicine, New Haven, Connecticut 06520-8029, USA. ursula.brewster@yale.edu
Hayslett
John P
JP
D000328:Adult; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use*; D003919:Diabetes Insipidus / Q000175:diagnosis* / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008423:Maternal Age; D011141:Polyuria / Q000175:diagnosis / Q000188:drug therapy; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D011263:Pregnancy Trimester, Third; D018570:Risk Assessment; D016896:Treatment Outcome; D014667:Vasopressins / Q000096:biosynthesis* / Q000187:drug effects
D014667:Vasopressins; D003894:Deamino Arginine Vasopressin