title: Beyond major depression.
abstract: BACKGROUND
  The DSM concept of 'major depression' has accrued increased status but demonstrated limited utility since inception.
  
  
  METHODS
  An historical overview of models of depression and the initially perceived advantages presented by the concept of 'major depression' are presented before detailing its limitations in application.
  
  
  RESULTS
  Challenges to the utility of 'major depression' are provided by examining its conceptual model, its validity, its utility and the limited information generated in aetiological and treatment efficacy studies.
  
  
  CONCLUSIONS
  It is argued that the concept of 'major depression' has led to sterility in depression research and clinical practice, and that there is a need for a paradigm shift in modelling and classifying the depressive disorders.
authors.affiliation: School of Psychiatry, University of New South Wales, and Black Dog Institute, Prince of Wales Hospital, Sydney, Australia. g.parker@unsw.edu.au
authors.forename: Gordon
authors.initials: G
authors.lastname: Parker
mesh_terms: D003866:Depressive Disorder / Q000145:classification / Q000175:diagnosis / Q000523:psychology; D003865:Major Depressive Disorder / Q000145:classification / Q000175:diagnosis* / Q000523:psychology; D003937:Diagnosis, Differential; D039721:Diagnostic and Statistical Manual of Mental Disorders; D006801:Humans; D015203:Reproducibility of Results