Variation in immunogenicity of ruminant pestiviruses as determined by the neutralisation assay.
Immunogenicity in naive three-month-old Friesian bull calves of nine ruminant pestiviruses, three each of type 1 bovine virus diarrhoea virus (BVDV), type 2 BVDV and border disease virus (BDV) was directly compared in reciprocal cross-neutralisation tests using sera obtained eight weeks after intranasal and intravenous inoculation with live virus. Cytopathic (CP) type 1 BVDV strain C86, non-cytopathic (NCP) type 2 BVDV strain 890 and NCP BDV strain V2536/2 were found to elicit significantly broad cross-neutralising antibodies against viruses in other species whereas other virus strains in all three species produced a much more pronounced homologous and/or species specific response. Results are clearly relevant in the selection of strains for vaccines against diseases caused by these successful, economically important ubiquitous viruses.
Patel
J R
JR
Intervet UK Ltd., Walton, Milton Keynes, Buckinghomshire MK7 7AJ, UK.
Didlick
S
S
Quinton
J
J
D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000096:biosynthesis*; D002417:Cattle; D002418:Cattle Diseases / Q000821:virology*; D008297:Male; D009500:Neutralization Tests / Q000662:veterinary; D010576:Pestivirus / Q000276:immunology*; D018182:Pestivirus Infections / Q000662:veterinary* / Q000821:virology; D014611:Vaccination / Q000662:veterinary; D014765:Viral Vaccines / Q000627:therapeutic use
D000914:Antibodies, Viral; D014765:Viral Vaccines