title: Imaging spectrum in disseminated histoplasmosis: case report and brief review.
abstract: The clinical manifestations of chronic disseminated histoplasmosis are non-specific and resemble those of other chronic infections and malignancies. We report the radiographic, sonographic and contrast-enhanced CT appearances of histoplasmosis in an adult male with non-insulin dependent diabetes mellitus, who was HIV negative and presented with weight loss and pyrexia. Imaging studies simulated tuberculosis with mediastinal lymphadenopathy, bilateral fibrotic lung lesions, hepatomegaly and bilateral hypoattenuating adrenal enlargement, without clinical or laboratory evidence of hypoadrenalism. Computed tomography-guided fine-needle aspiration biopsy of adrenal glands revealed Histoplasma capsulatum. We report our experience to increase awareness of the imaging spectrum of disseminated histoplasmosis and its similarity to tuberculosis as, with increasing incidence of AIDS, the chances of these infections are likely to increase. Moreover, awareness of this entity is important because it is known that untreated disseminated histoplasmosis is fatal.
authors.affiliation: Department of Radiodiagnosis, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India. shabnamgrover@yahoo.com
authors.forename: S B
authors.initials: SB
authors.lastname: Grover
authors.forename: N
authors.initials: N
authors.lastname: Midha
authors.forename: M
authors.initials: M
authors.lastname: Gupta
authors.forename: U
authors.initials: U
authors.lastname: Sharma
authors.forename: V H
authors.initials: VH
authors.lastname: Talib
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D003287:Contrast Media; D003937:Diagnosis, Differential; D006660:Histoplasmosis / Q000000981:diagnostic imaging* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D000935:Antifungal Agents; D003287:Contrast Media