Spectrum of antiviral activity of o-(acetoxyphenyl)hept-2-ynyl sulphide (APHS).
Since some antiviral drugs have a broad spectrum of action, the aim of this study was to assess whether o-(acetoxyphenyl)hept-2-ynyl sulphide (APHS), a recently described inhibitor of human immunodeficiency virus type 1 (HIV-1) replication, has an effect on the replication of other retroviruses, (-) and (+) RNA viruses and DNA viruses. APHS did not affect the replication of feline immunodeficiency virus, HIV-2 and a HIV-1 strain resistant to non-nucleoside reverse transcriptase inhibitors (NNRTI). APHS could also not inhibit the replication of the RNA viruses, respiratory syncytium virus or mouse hepatitis virus. In contrast, APHS did inhibit the replication of wild-type herpes simplex virus type 1 (HSV-1) as well as acyclovir-resistant HSV-1 and HSV-2 mutant. These results suggest that APHS is a NNRTI of HIV-1 replication, but not HIV-2 replication, and that APHS is an inhibitor of both HSV-1 and HSV-2 replication.
Pereira
Cândida F
CF
Eijkman-Winkler Center, Hp G04.614, University Medical Center Utrecht, Heidelberglaan 100, NL-3584 CX Utrecht, The Netherlands.
Rutten
Karla
K
Stránská
Růzena
R
Huigen
Marleen C D G
MC
Aerts
Piet C
PC
de Groot
Raoul J
RJ
Egberink
Herman F
HF
Schuurman
Rob
R
Nottet
Hans S L M
HS
D000212:Acyclovir / Q000494:pharmacology; D000480:Alkynes; D000818:Animals; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D024881:Drug Resistance, Bacterial; D015497:HIV-1 / Q000187:drug effects; D015498:HIV-2 / Q000187:drug effects; D006536:Heptanes / Q000494:pharmacology*; D018259:Herpesvirus 1, Human / Q000187:drug effects / Q000235:genetics; D018258:Herpesvirus 2, Human / Q000187:drug effects / Q000235:genetics; D006801:Humans; D016086:Lentivirus / Q000187:drug effects*; D009000:Monocytes / Q000821:virology; D006517:Murine hepatitis virus / Q000187:drug effects; D009154:Mutation; D012136:Respiratory Syncytial Viruses / Q000187:drug effects; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology; D013440:Sulfides / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
D000480:Alkynes; D006536:Heptanes; D018894:Reverse Transcriptase Inhibitors; D013440:Sulfides; C112390:o-(acetoxyphenyl)hept-2-ynyl sulfide; D000212:Acyclovir