title: Tumor necrosis factor alpha plays a role in the acceleration of atherosclerosis by Chlamydia pneumoniae in mice.
abstract: The role of tumor necrosis factor alpha (TNF-alpha) in Chlamydia pneumoniae atherogenesis was evaluated in TNF-alpha p55 receptor-deficient C57BL/6J mice fed a high-fat/high-cholesterol diet. No acceleration of atherosclerotic lesion development was observed in infected mice compared to uninfected mice, indicating that TNF-alpha plays a role in the acceleration of atherosclerosis by C. pneumoniae.
authors.affiliation: Department of Pathobiology, Box 357238, University of Washington, Seattle, WA 98195, USA.
authors.forename: Lee Ann
authors.initials: LA
authors.lastname: Campbell
authors.forename: Tadayoshi
authors.initials: T
authors.lastname: Nosaka
authors.forename: Michael E
authors.initials: ME
authors.lastname: Rosenfeld
authors.forename: Kambiz
authors.initials: K
authors.lastname: Yaraei
authors.forename: Cho-Chou
authors.initials: CC
authors.lastname: Kuo
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000382:microbiology* / Q000503:physiopathology*; D023521:Chlamydophila Infections / Q000382:microbiology / Q000503:physiopathology; D016993:Chlamydophila pneumoniae / Q000378:metabolism / Q000472:pathogenicity*; D006949:Hyperlipidemias / Q000382:microbiology* / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics; D047888:Receptors, Tumor Necrosis Factor, Type I; D053319:Tumor Necrosis Factor Decoy Receptors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D018124:Receptors, Tumor Necrosis Factor; D047888:Receptors, Tumor Necrosis Factor, Type I; D053319:Tumor Necrosis Factor Decoy Receptors; D014409:Tumor Necrosis Factor-alpha; C069521:recombinant human tumor necrosis factor-binding protein-1