title: Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones.
abstract: Design, new synthesis, structure-activity relationship studies and calcium receptor antagonist (calcilytic) properties of novel 3H-pyrimidin-4-ones are described.
authors.affiliation: Drug Discovery, NPS Pharmaceuticals, Inc., 383 Colorow Drive, Salt Lake City, UT 84108, USA. ishcherbakova@npsp.com
authors.forename: Irina
authors.initials: I
authors.lastname: Shcherbakova
authors.forename: Guangfei
authors.initials: G
authors.lastname: Huang
authors.forename: Otto J
authors.initials: OJ
authors.lastname: Geoffroy
authors.forename: Satheesh K
authors.initials: SK
authors.lastname: Nair
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Swierczek
authors.forename: Manuel F
authors.initials: MF
authors.lastname: Balandrin
authors.forename: John
authors.initials: J
authors.lastname: Fox
authors.forename: William L
authors.initials: WL
authors.lastname: Heaton
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Conklin
mesh_terms: D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D044169:Receptors, Calcium-Sensing / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D011744:Pyrimidinones; D044169:Receptors, Calcium-Sensing