Altered expression patterns of metabotropic glutamate receptors in diffuse brain injury.
The metabotropic glutamate receptors (mGluRs), as one of the newly found glutamate receptors, play an important role in the physiological processes of the central nervous system. The authors examined the changes of expression patterns of mGluRs after diffuse brain injuries (DBI) in rats. DBI was produced by Marmarou's methods. The mRNA expression of mGluRs was detected by hybridization in situ at different time points after brain injuries. Compared with normal control and sham-operated control, the animals with DBI showed a significantly increased expression of group I and group III mGluRs (except mGluR6, P<0.05). The increased peak of group I appeared at 24 h after injuries and group III at 6 h after injuries. While, group II mGluRs decreased after DBI (P<0.05) and the lowest point occurred at 48 h after DBI. The difference of time sequence of the expression alterations between group I and group III mGluRs may reflect a self-protection first mechanism of the damaged neurons. It may provide new insight for the development of new pharmaceuticals in the treatment of DBI.
Fei
Zhou
Z
Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, PR China. feizhou@fmmu.edu.cn
Zhang
Xiang
X
Jiang
Xiao-fan
XF
Huang
Wei-dong
WD
Bai
Hong-min
HM
D000818:Animals; D001930:Brain Injuries / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D002540:Cerebral Cortex / Q000378:metabolism* / Q000503:physiopathology; D020833:Diffuse Axonal Injury / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D004195:Disease Models, Animal; D015870:Gene Expression / Q000502:physiology; D018698:Glutamic Acid / Q000378:metabolism; D008297:Male; D009474:Neurons / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics*; D013997:Time Factors; D015854:Up-Regulation / Q000235:genetics
D012333:RNA, Messenger; D018094:Receptors, Metabotropic Glutamate; D018698:Glutamic Acid