[Haematological abnormalities during treatment with atypical antipsychotics].
The danger of severe haematological abnormalities limits the use of clozapine in the treatment of psychoses. The development of modern second generation antipsychotics such as olanzapine, risperidone, quetiapine, amisulpride, ziprasidone or aripiprazol, however, makes it possible to use the positive effects of this class of drugs without the risks of a clozapine treatment. Nevertheless, there are several case reports about severe haematological abnormalities even during treatment with these second generation antipsychotics. This review summarises recently published cases and discusses the consequences for the daily clinical work.
Thome
Johannes
J
Department of Psychiatry, School of Medicine, University of Wales Swansea, United Kingdom. j.thome@swan.ac.uk
Kopf
Daniel
D
D000328:Adult; D000380:Agranulocytosis / Q000097:blood / Q000139:chemically induced*; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000145:classification* / Q000627:therapeutic use; D003024:Clozapine / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D007970:Leukopenia / Q000097:blood / Q000139:chemically induced*; D008297:Male; D011618:Psychotic Disorders / Q000097:blood / Q000188:drug therapy*; D012307:Risk Factors
D014150:Antipsychotic Agents; D003024:Clozapine