title: The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations.
abstract: Vascular and angiogenic processes provide an important target for novel cancer therapeutics. Dynamic contrast-enhanced magnetic resonance imaging is being used increasingly to noninvasively monitor the action of these therapeutics in early-stage clinical trials. This publication reports the outcome of a workshop that considered the methodology and design of magnetic resonance studies, recommending how this new tool might best be used.
authors.affiliation: Cancer Research UK Clinical Magnetic Resonance Research Group, Institute of Cancer Research, Royal Marsden Hospital, Sutton, Surrey, UK. martin.leach@icr.ac.uk
authors.forename: M O
authors.initials: MO
authors.lastname: Leach
authors.forename: K M
authors.initials: KM
authors.lastname: Brindle
authors.forename: J L
authors.initials: JL
authors.lastname: Evelhoch
authors.forename: J R
authors.initials: JR
authors.lastname: Griffiths
authors.forename: M R
authors.initials: MR
authors.lastname: Horsman
authors.forename: A
authors.initials: A
authors.lastname: Jackson
authors.forename: G C
authors.initials: GC
authors.lastname: Jayson
authors.forename: I R
authors.initials: IR
authors.lastname: Judson
authors.forename: M V
authors.initials: MV
authors.lastname: Knopp
authors.forename: R J
authors.initials: RJ
authors.lastname: Maxwell
authors.forename: D
authors.initials: D
authors.lastname: McIntyre
authors.forename: A R
authors.initials: AR
authors.lastname: Padhani
authors.forename: P
authors.initials: P
authors.lastname: Price
authors.forename: R
authors.initials: R
authors.lastname: Rathbone
authors.forename: G J
authors.initials: GJ
authors.lastname: Rustin
authors.forename: P S
authors.initials: PS
authors.lastname: Tofts
authors.forename: G M
authors.initials: GM
authors.lastname: Tozer
authors.forename: W
authors.initials: W
authors.lastname: Vennart
authors.forename: J C
authors.initials: JC
authors.lastname: Waterton
authors.forename: S R
authors.initials: SR
authors.lastname: Williams
authors.forename: P
authors.initials: P
authors.lastname: Workman
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005069:Evaluation Studies as Topic; D008279:Magnetic Resonance Imaging; D009369:Neoplasms / Q000098:blood supply* / Q000188:drug therapy*; D015203:Reproducibility of Results; D009626:Terminology as Topic
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents