title: Regulation of the anti-allograft response by targeting the CD2 antigen: a potential strategy for the creation of transplant tolerance.
abstract: Activated T cells playa central role in the rejection of histoincompatible organ allografts. Studies of trans- membrane signaling requirements ofT cells, by identifying molecular and cellular mechanisms ofT-cell activation, can lead to rational therapeutic strategies for the regulation of the anti-allograft response. A clear consensus exists that the primary signal for T-cell activation is generated as a consequence of the in- teractions among the T-cell receptor for antigen (TCR)I cluster designation 3 (CD3) complex and the antigenic peptide presented in the context of major histocompatibility complex (MHC) proteins expressed on the sur- face of the antigen-presenting cells (APCs). '-7 The TCR/CD3-dependent signaling is necessary but insufficient in itself to fully activate normal human primary (quiescent) T cells, and additional costimulatory signals are required for full activatiori.
authors.affiliation: Department of Surgery, The New York Hospital-Cornell University Medical Center, NY, USA.
authors.forename: S
authors.initials: S
authors.lastname: Kapur
authors.forename: V
authors.initials: V
authors.lastname: Sharma
authors.forename: A
authors.initials: A
authors.lastname: Khanna
authors.forename: B
authors.initials: B
authors.lastname: Li
authors.forename: K
authors.initials: K
authors.lastname: Sukol
authors.forename: M
authors.initials: M
authors.lastname: Suthanthiran