title: [Expression of eotaxin gene in nasal mucosa of allergic rhinitis in the guinea pig sensitized by fungal allergen].
abstract: OBJECTIVE
  To study the expression and significance of Eotaxin gene in nasal mucosa of guinea pig sensitized by fungal allergen.
  
  
  METHODS
  Alternaria alternata sensitized guinea pigs used as animal model of allergic rhinitis (AR). The changes in the nasal mucosa were studied by pathological method and the Eotaxin gene were studied by In Situ Hybridization.
  
  
  RESULTS
  The behavior science score of experimental group was significant higher than the controls group. Plenty eosinophils were found in lamina propria of nasal mucosa of experimental group. Eotaxin gene is expressed in lamina propria of nasal mucosa of experimental group. The controls group had not positive expression.
  
  
  CONCLUSIONS
  Eotaxin gene is expressed at high levels in nasal mucosa of fungal allergic rhinitis in the guinea pig. Plenty eosinophils were found in nasal mucosa. We considered that Eotaxin gene and eosinophils could play a key role in fungal allergic rhinitis.
authors.affiliation: Department of Otorhinolaryngology, First Hospital, China Medical University, Shenyang, 110003, China. zjk2002@tom.com
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Zhang
authors.forename: Shuyan
authors.initials: S
authors.lastname: Sun
authors.forename: Shouchen
authors.initials: S
authors.lastname: Wang
authors.forename: Wenyue
authors.initials: W
authors.lastname: Ji
authors.forename: Chao
authors.initials: C
authors.lastname: Guan
mesh_terms: D000528:Alternaria; D000818:Animals; D000946:Antigens, Fungal; D054413:Chemokine CCL11; D019742:Chemokines, CC / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D006168:Guinea Pigs; D008297:Male; D009297:Nasal Mucosa / Q000473:pathology*; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology / Q000382:microbiology / Q000473:pathology*
chemical_list: D000946:Antigens, Fungal; D054413:Chemokine CCL11; D019742:Chemokines, CC