title: From pancreatic intraepithelial neoplasia to cancer: a dramatic progression with K-ras status analysis.
abstract: Pancreatic ductal carcinomas are thought to arise from precursor ductal lesions called pancreatic intra-epithelial neoplasias or PanINs. We report the case of a woman suffering from idiopathic chronic pancreatitis associated with PanINs lesions who developed six years later an invasive ductal carcinoma. Immunohistochemistry for p53, HER-2/neu and genetic analysis of K-ras oncogene were performed at different stages of disease and revealed that the PanINs and the carcinoma did not express p53 and HER-2/neu gene products whereas a K-ras mutation was present at the carcinoma stage. The relationship between cancer and chronic pancreatitis and the main difficulties concerning the early diagnostic of pancreatic cancer are discussed.
authors.affiliation: Department of Pathology, Hôpital Sainte-Marguerite, Marseille, France.
authors.forename: Carla
authors.initials: C
authors.lastname: Fernandez
authors.forename: Bruno
authors.initials: B
authors.lastname: Chetaille
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Tasei
authors.forename: Bernard
authors.initials: B
authors.lastname: Sastre
authors.forename: José
authors.initials: J
authors.lastname: Sahel
authors.forename: Marie-José
authors.initials: MJ
authors.lastname: Payan-Defais
mesh_terms: D002278:Carcinoma in Situ / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology*; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D011905:Genes, ras / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology*