title: Brain injury and neuropsychological outcome after coronary artery surgery are affected by complement activation.
abstract: BACKGROUND
  The impact of the postoperative inflammatory response on the central nervous system after cardiac surgery is uncertain. The goal of the study was to evaluate the role of complement activation on cellular brain injury in patients undergoing coronary artery bypass grafting. In addition, neuropsychological functioning was assessed.
  
  
  METHODS
  We randomly assigned 30 patients to undergo surgery using either standard noncoated or heparin-coated extracorporeal circuits. Closed cardiopulmonary bypass and controlled suctions of pericardial shed blood were standardized in both groups. Complement activation and cellular brain injury were assessed by measuring sC5b-9 and protein s100beta. Neuropsychometric tests were performed at least 2 weeks before operation and at discharge. They served to calculate z scores of cognitive domains and changes in neuropsychological functioning.
  
  
  RESULTS
  Peak value of sC5b-9 at the end of cardiopulmonary bypass in the noncoated group was significantly higher than in the heparin-coated group (p = 0.005). Changes in the heparin-coated group were not significant. Glial injury started after initiation of surgery and peaked at the end of cardiopulmonary bypass with significantly higher concentration of s100beta in the noncoated than in the heparin-coated group (p = 0.008). Values of s100beta and of sC5b-9 were significantly correlated (p = 0.03). Although no statistically significant between group difference was detected, z scores of attention and flexibility or executive functions were lowered postoperatively within the noncoated group (p = 0.033 and p = 0.028), whereas z scores were unchanged within the heparin-coated group.
  
  
  CONCLUSIONS
  Inhibition of complement activation by heparin-coated cardiopulmonary bypass reduced brain cell injury and was associated with preserved neuropsychological functioning after coronary artery bypass grafting.
authors.affiliation: Department of Cardiovascular and Thoracic Surgery, University Hospital of Angers, Angers, France. chbaufreton@chu-angers.fr
authors.forename: Christophe
authors.initials: C
authors.lastname: Baufreton
authors.forename: Philippe
authors.initials: P
authors.lastname: Allain
authors.forename: Alain
authors.initials: A
authors.lastname: Chevailler
authors.forename: Frédérique
authors.initials: F
authors.lastname: Etcharry-Bouyx
authors.forename: Jean Jacques
authors.initials: JJ
authors.lastname: Corbeau
authors.forename: Didier
authors.initials: D
authors.lastname: Legall
authors.forename: Jean Louis
authors.initials: JL
authors.lastname: de Brux
mesh_terms: D000368:Aged; D001930:Brain Injuries / Q000209:etiology*; D003071:Cognition; D003167:Complement Activation; D015938:Complement Membrane Attack Complex / Q000032:analysis; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D006493:Heparin; D006801:Humans; D007249:Inflammation; D008875:Middle Aged; D009457:Neuroglia / Q000473:pathology; D009483:Neuropsychological Tests; D011183:Postoperative Complications
chemical_list: D015938:Complement Membrane Attack Complex; D006493:Heparin