title: Synthesis of pyrrolo[2,1-c][1,4]benzodiazepines and their conjugates by azido reductive cyclization strategy as potential DNA-binding agents.
abstract: Synthesis of pyrrolo[2,1-c][1,4]benzodiazepines via azido reductive cyclization process employing FeCl3-NaI reagent system. This methodology has been extended for the preparation of new nicotinamido-pyrrolobenzodiazepine hybrids linked through piperazino-alkane-oxy spacers that exhibit good DNA binding affinity.
authors.affiliation: Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Kamal
authors.forename: A Hari
authors.initials: AH
authors.lastname: Babu
authors.forename: A Venkata
authors.initials: AV
authors.lastname: Ramana
authors.forename: K Venkata
authors.initials: KV
authors.lastname: Ramana
authors.forename: E Vijaya
authors.initials: EV
authors.lastname: Bharathi
authors.forename: M Shiva
authors.initials: MS
authors.lastname: Kumar
mesh_terms: D001386:Azides / Q000737:chemistry*; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D004587:Electrophoresis, Agar Gel
chemical_list: D001386:Azides; D001569:Benzodiazepines; D004247:DNA