title: [Investigation of local reaction of muscular tissue after injection of polyvinylpyrrolidone preparation].
abstract: Natural preparations for replenishing of hyaluronic acid of zoogenous origin used till now, are characterized with quit low biocompatibility and also too short effect of their action. Recently worked out synthetic polyvinylpyrrolidone preparation PVP, contains modification constituting internally netting of microgels to improve polymer bioresistance. The introduce modification can, however influence PVP biocompatibility after deposition into tissues of the living organism. The aim of research was evaluation of the local reaction of muscular tissue after PVP infection. The results of research concerned a control group where normal saline was used for infections. The research was carried out on 18 Wistar rats and included macroscopic and histologic observations made in the 3rd, 5th, 7th, 14th and 30th day after PVP injection into thigh muscle. The local reaction of muscular tissue was macroscopically characterized with inflammatory reaction till the 7th day after PVP injection, in later terms the observed changes disappeared. Microscopic research showed that PVP till the 7th day after PVP injection caused rather strong diffuse non-specific inflammatory process, yet without essential participation of neutrophils leading to producing of loose intra-muscular. Connective tissue in a later term. The carried out tests showed presence of PVP in muscular tissue till the 30th day after injection.
authors.affiliation: Zakład Chirurgii Eksperymentalnej i Badania Biomateriałów Akademii Medycznej we Wrocławiu. implant@cheksp.am.wroc.pl
authors.forename: Stanisław
authors.initials: S
authors.lastname: Pielka
authors.forename: Bogusława
authors.initials: B
authors.lastname: Zywicka
authors.forename: Janusz
authors.initials: J
authors.lastname: Rosiak
authors.forename: Artur
authors.initials: A
authors.lastname: Henke
authors.forename: Piotr
authors.initials: P
authors.lastname: Ulański
authors.forename: Danuta
authors.initials: D
authors.lastname: Paluch
authors.forename: Maria
authors.initials: M
authors.lastname: Szymonowicz
authors.forename: Leszek
authors.initials: L
authors.lastname: Solski
authors.forename: Jolanta
authors.initials: J
authors.lastname: Staniszewska-Kuś
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D005260:Female; D005549:Foreign-Body Reaction; D007273:Injections, Intramuscular; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000473:pathology*; D011205:Povidone / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D011205:Povidone