Structure-activity relationships of arylbenzofuran H3 receptor antagonists.
An SAR study of histamine H3 receptor antagonists based on substituted (R)-2-methyl-1-[2-(5-phenyl-benzofuran-2-yl)-ethyl]-pyrrolidines is presented.
Gfesser
Gregory A
GA
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA. greg.gfesser@abbott.com
Faghih
Ramin
R
Bennani
Youssef L
YL
Curtis
Michael P
MP
Esbenshade
Timothy A
TA
Hancock
Arthur A
AA
Cowart
Marlon D
MD
D001572:Benzofurans / Q000737:chemistry* / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D011759:Pyrrolidines / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D018100:Receptors, Histamine H3 / Q000187:drug effects*; D013329:Structure-Activity Relationship
D001572:Benzofurans; D006634:Histamine H1 Antagonists; D011759:Pyrrolidines; D018100:Receptors, Histamine H3; C105430:benzofuran