title: Comparison of in vitro activities of antifungal drugs and ethanolic extract of propolis against Trichophyton rubrum and T. mentagrophytes by using a microdilution assay.
abstract: The in vitro activities of propolis against 29 strains of dermatophytes were compared with those of terbinafine, itraconazole, ketoconazole, and fluconazole. Minimal inhibitory concentrations (MICs) were determined according to a National Committee for Clinical Laboratory Standards broth microdilution method. Among the systemic antifungals tested, terbinafine was the most potent. Propolis showed important antifungal activity and it merits further investigation as a potentially useful agent for the treatment of dermatophytosis.
authors.affiliation: Medical Faculty, Department of Microbiology, Erciyes University, Kayseri, Turkey.
authors.forename: A N
authors.initials: AN
authors.lastname: Koc
authors.forename: S
authors.initials: S
authors.lastname: Silici
authors.forename: D
authors.initials: D
authors.lastname: Ayangil
authors.forename: A
authors.initials: A
authors.lastname: Ferahbaş
authors.forename: S
authors.initials: S
authors.lastname: Cankaya
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D015725:Fluconazole / Q000494:pharmacology; D017964:Itraconazole / Q000494:pharmacology; D007654:Ketoconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000494:pharmacology; D011429:Propolis / Q000737:chemistry / Q000494:pharmacology*; D000077291:Terbinafine; D014249:Trichophyton / Q000187:drug effects*; D014421:Turkey
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D017964:Itraconazole; D015725:Fluconazole; D011429:Propolis; D000077291:Terbinafine; D007654:Ketoconazole