Anti-HIV protease activity from rosa family plant extracts and rosamultin from Rosa rugosa.
To identify substances with anti-human immunodeficiency virus (HIV) activity from plant sources, 12 extracts of Rosa family plants were screened for their inhibitory effects against HIV-1 protease. Of the extracts tested, the strongest inhibitory effects were observed in the root of Rosa rugosa and the leaves of Prunus sargentii, at a concentration of 100 microg/mL. Rosamultin isolated from the root of R. rugosa inhibited HIV-1 protease by 53% at a concentration of 100 microM.
Park
Jong Cheol
JC
Department of Oriental Medicine Resources and Research Institute of Korean Oriental Medicine, Sunchon National University, Suncheon, Jeonnam, Republic of Korea. flavonoid@empal.com
Kim
Sang Chul
SC
Choi
Myeong Rak
MR
Song
Sang Ho
SH
Yoo
Eun Jeong
EJ
Kim
Sung Hwan
SH
Miyashiro
Hirotsugu
H
Hattori
Masao
M
D019380:Anti-HIV Agents / Q000494:pharmacology / Q000627:therapeutic use; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D015658:HIV Infections / Q000188:drug therapy*; D016333:HIV Protease / Q000187:drug effects / Q000378:metabolism; D017320:HIV Protease Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D015497:HIV-1 / Q000201:enzymology / Q000235:genetics; D006801:Humans; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D027826:Rosa / Q000737:chemistry*; D016896:Treatment Outcome; D014315:Triterpenes / Q000494:pharmacology / Q000627:therapeutic use*
D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D010936:Plant Extracts; D014315:Triterpenes; C051431:rosamultin; D016333:HIV Protease