title: Bullous Sweet's syndrome in congenital neutropenia: association with pegfilgrastim.
abstract: Sweet's syndrome is an acute febrile neutrophilic dermatosis marked by attacks of painful, plaque-forming inflammatory papules accompanied by fever, arthralgias, peripheral leukocytosis, a diffuse dermal neutrophilic infiltrate, and prompt resolution of symptoms and lesions with glucocorticoid therapy. There are many reports of drug-induced Sweet's syndrome to various medications including all- trans -retinoic acid, carbamazepine, hydralazine, levonorgestrel/ethinyl estradiol, minocycline, trimethoprim/sulfamethoxazole, and granulocyte colony-stimulating factor. We describe the first known case of Sweet's syndrome induced by pegfilgrastim, a pegylated form of granulocyte colony-stimulating factor with unique pharmacologic properties that may induce Sweet's syndrome in patients with no history of neutrophilic dermatoses associated with granulocyte colony-stimulating factor therapy.
authors.affiliation: Department of Medicine, Division of Dermatology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
authors.forename: Bradley K
authors.initials: BK
authors.lastname: Draper
authors.forename: Jason B
authors.initials: JB
authors.lastname: Robbins
authors.forename: Jason R
authors.initials: JR
authors.lastname: Robbins
authors.forename: George P
authors.initials: GP
authors.lastname: Stricklin
mesh_terms: D001768:Blister / Q000139:chemically induced* / Q000188:drug therapy; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000151:congenital* / Q000188:drug therapy; D009504:Neutrophils / Q000166:cytology; D011092:Polyethylene Glycols; D011994:Recombinant Proteins; D016463:Sweet Syndrome / Q000139:chemically induced*
chemical_list: D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; C455861:pegfilgrastim; D011092:Polyethylene Glycols; D000069585:Filgrastim