title: Structure-based design of protein tyrosine phosphatase-1B inhibitors.
abstract: Using structure-based design, a new class of inhibitors of protein tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the 1,2,5-thiadiazolidin-3-one-1,1-dioxide template.
authors.affiliation: AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK.
authors.forename: Emma
authors.initials: E
authors.lastname: Black
authors.forename: Jason
authors.initials: J
authors.lastname: Breed
authors.forename: Alexander L
authors.initials: AL
authors.lastname: Breeze
authors.forename: Kevin
authors.initials: K
authors.lastname: Embrey
authors.forename: Robert
authors.initials: R
authors.lastname: Garcia
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Gero
authors.forename: Linda
authors.initials: L
authors.lastname: Godfrey
authors.forename: Peter W
authors.initials: PW
authors.lastname: Kenny
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Morley
authors.forename: Claire A
authors.initials: CA
authors.lastname: Minshull
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Pannifer
authors.forename: Jon
authors.initials: J
authors.lastname: Read
authors.forename: Amanda
authors.initials: A
authors.lastname: Rees
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Russell
authors.forename: Dorin
authors.initials: D
authors.lastname: Toader
authors.forename: Julie
authors.initials: J
authors.lastname: Tucker
mesh_terms: D018360:Crystallography, X-Ray; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013829:Thiadiazines / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D008024:Ligands; D013829:Thiadiazines; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases