Increased risk of colorectal cancer due to interactions between meat consumption and the CD36 gene A52C polymorphism among Japanese.
A previous study showed expression of CD36, recently reported to play important roles in metabolism of oxidized low-density lipoprotein and long-chain fatty acids and to be positively correlated with colon cancer prognosis. To examine relationships between colorectal cancer and the CD36 gene A52C polymorphism according to meat consumption as a surrogate for saturated fatty acid intake, we conducted the present hospital-based, case-control study of 128 cases and 238 non-cancer controls. Consumption of meat and vegetables/fruit was divided into three (low, moderate, and high) and two (low and high) groups, respectively. Regarding the risk of colorectal cancer on cross-classifying subjects for the CD36 genotype and meat consumption, the odds ratio (OR) for the C/C genotype with moderate meat consumption relative to the A/A genotype with low meat consumption was 8.30 (95% confidence interval, CI=2.15-32.00). None of individuals with the C/C genotype was in the high meat consumption group. In the low vegetables/fruit consumption group, the OR for the C/C genotype relative to the A/A genotype was 3.03 (95% CI=1.12-7.90). Our findings suggest that interactions between moderate-high meat consumption and the CD36 gene A52C polymorphism may increase the risk of colorectal cancer.
Kuriki
Kiyonori
K
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan. kkuriki@aichi-cc.jp
Hamajima
Nobuyuki
N
Chiba
Hitoshi
H
Kanemitsu
Yukihide
Y
Hirai
Takashi
T
Kato
Tomoyuki
T
Saito
Toshiko
T
Matsuo
Keitaro
K
Koike
Koichi
K
Tokudome
Shinkan
S
Tajima
Kazuo
K
D000328:Adult; D000368:Aged; D000818:Animals; D018955:CD36 Antigens / Q000235:genetics*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D004032:Diet / Q000009:adverse effects*; D005260:Female; D005638:Fruit; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008019:Life Style; D008297:Male; D008460:Meat / Q000009:adverse effects*; D008875:Middle Aged; D008892:Milk; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics* / Q000502:physiology; D012307:Risk Factors; D014675:Vegetables
D018955:CD36 Antigens