title: In vitro suppression of latent HIV-1 activation by vitamin E: potential clinical implications.
abstract: We evaluated the effect of vitamin E in controlling HIV-1 production upon activation of the patients' reservoir of resting CD4 lymphocytes in tissue culture experiments. The addition of vitamin E to patients' cultures resulted in significantly reduced levels of p24 virus production (P = 0.0015). These results suggest that vitamin E supplementation may interfere with the emergence of drug-resistant HIV-1 variants archived in the resting cell reservoir and delay or limit virus rebound upon treatment interruptions.
authors.affiliation: Division of Clinical Research, Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, MD, USA.
authors.forename: Alonso
authors.initials: A
authors.lastname: Heredia
authors.forename: Charles
authors.initials: C
authors.lastname: Davis
authors.forename: Anthony
authors.initials: A
authors.lastname: Amoroso
authors.forename: Greg
authors.initials: G
authors.lastname: Taylor
authors.forename: Nhut
authors.initials: N
authors.lastname: Le
authors.forename: Douty
authors.initials: D
authors.lastname: Bamba
authors.forename: Robert R
authors.initials: RR
authors.lastname: Redfield
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use*; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D002478:Cells, Cultured; D003864:Depression, Chemical; D016655:HIV Core Protein p24 / Q000032:analysis; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D017735:Virus Latency / Q000187:drug effects; D014810:Vitamin E / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D016655:HIV Core Protein p24; D014810:Vitamin E