title: Influence of repetitive transcranial magnetic stimulation on disease severity and oxidative stress markers in the cerebrospinal fluid of patients with spinocerebellar degeneration.
abstract: Ataxia severity, cerebellar hemispheric blood flow (CHBF), ascorbate free radical (AFR), superoxide dismutase protein, superoxide scavenging activity, and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in cerebrospinal fluid (CSF) were compared before and after an 8-week course of repetitive transcranial magnetic stimulation (rTMS) in 20 patients with spinocerebellar degenerations (SCD). SCD patients showed higher AFR, 8-OHdG, and superoxide scavenging activity than 19 controls. In SCD patients, AFR and ataxia severity declined, and CHBF increased after rTMS. As the SCD patients showed negative correlations between ataxia severity and CHBF or superoxide scavenging activity, the therapeutic mechanism of rTMS may involve decreased oxidative stress and increased CHBF.
authors.affiliation: Clinical Research Institute and Department of Neurology, National Hospital Organization Minami-Okayama Medical Center, 4066 Hayashima-cho, Tsukubo-gun, Okayama 701-0304, Japan. iharay@s-okayama.hosp.go.jp
authors.forename: Yuetsu
authors.initials: Y
authors.lastname: Ihara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takata
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Tanabe
authors.forename: Keigo
authors.initials: K
authors.lastname: Nobukuni
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Hayabara
mesh_terms: D000328:Adult; D001205:Ascorbic Acid / Q000134:cerebrospinal fluid; D002560:Cerebrovascular Circulation / Q000502:physiology; D003839:Deoxyadenosines / Q000134:cerebrospinal fluid; D004599:Electric Stimulation Therapy / Q000379:methods; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D016166:Free Radical Scavengers / Q000134:cerebrospinal fluid*; D006801:Humans; D008875:Middle Aged; D018384:Oxidative Stress; D012039:Regional Blood Flow / Q000502:physiology; D012720:Severity of Illness Index; D013132:Spinocerebellar Degenerations / Q000134:cerebrospinal fluid / Q000145:classification / Q000503:physiopathology / Q000601:surgery; D013482:Superoxide Dismutase / Q000134:cerebrospinal fluid; D013997:Time Factors; D050781:Transcranial Magnetic Stimulation
chemical_list: C436623:8-hydroxy-2'-deoxyadenosine; D003839:Deoxyadenosines; D016166:Free Radical Scavengers; D013482:Superoxide Dismutase; D001205:Ascorbic Acid