Optimized voxel-based morphometry of gray matter volume in first-episode, antipsychotic-naive schizophrenia.
This study examined gray matter (GM) volume abnormalities in first-episode, antipsychotic-naïve Indian schizophrenia patients. Magnetic resonance images of 18 schizophrenia patients and 18 matched healthy comparison subjects were analyzed by optimized voxel-based morphometry. Schizophrenia patients had significantly smaller global GM and greater global CSF volumes and smaller regional GM volume in superior frontal, inferior frontal, cingulate, post-central, superior temporal and parahippocampal gyri, inferior parietal lobule, insula, caudate nuclei, thalamus and cerebellum. Findings suggest limbic, heteromodal cortical, striatal, thalamic and cerebellar abnormalities in schizophrenia.
Jayakumar
Peruvamba N
PN
Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Hosur road, Bangalore 560029, India. jayakumarpn@nimhans.kar.nic.in
Venkatasubramanian
Ganesan
G
Gangadhar
Bangalore N
BN
Janakiramaiah
Nimmagadda
N
Keshavan
Matcheri S
MS
D000328:Adult; D001921:Brain / Q000473:pathology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000473:pathology*