Decrease of kappa-opioid receptor mRNA level in ventral tegmental area of male mice after repeated experience of aggression.
Brain opioid systems have been implicated in the regulation of social interaction, including agonistic behaviour. kappa-Opioid receptor B and C mRNA levels were decreased in the ventral tegmental area but not in the nucleus accumbens in male mice with repeated experience of social victories (winners), but not in mice after social defeats (losers) after 10 but not 20 days of confrontations. mu-Opioid receptor mRNA levels were not changed.
Goloshchapov
Andrey V
AV
Institute of Bioorganic Chemistry SD RAS, Novosibirsk, Russia.
Filipenko
Maxim L
ML
Bondar
Natalia P
NP
Kudryavtseva
Natalia N
NN
Van Ree
Jan M
JM
D000374:Aggression / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D015152:Blotting, Northern / Q000379:methods; D021983:Cyclophilins / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009714:Nucleus Accumbens / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D017473:Receptors, Opioid, kappa / Q000235:genetics / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D012919:Social Behavior; D017557:Ventral Tegmental Area / Q000378:metabolism*
D012333:RNA, Messenger; D017473:Receptors, Opioid, kappa; D021983:Cyclophilins