title: Metabolon formation and metabolic channeling in the biosynthesis of plant natural products.
abstract: Metabolon formation and metabolic channeling in plant secondary metabolism enable plants to effectively synthesize specific natural products and to avoid metabolic interference. Channeling can involve different cell types, take advantage of compartmentalization within the same cell or proceed directly within a metabolon. New experimental approaches document the importance of channeling in the synthesis of isoprenoids, alkaloids, phenylpropanoids, flavonoids and cyanogenic glucosides. Metabolon formation and metabolic channeling in natural-product synthesis facilitate attempts to genetically engineer new pathways into plants to improve their content of valuable natural products. They also offer the opportunity to introduce new traits by genetic engineering to produce plant cultivars that adhere to the principle of substantial equivalence.
authors.affiliation: Plant Biochemistry Laboratory, Department of Plant Biology, Royal Veterinary and Agricultural University, 40 Thorvaldsensvej, DK-1871 Frederiksberg C, Copenhagen, Denmark.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Jørgensen
authors.forename: Anne Vinther
authors.initials: AV
authors.lastname: Rasmussen
authors.forename: Marc
authors.initials: M
authors.lastname: Morant
authors.forename: Allan Holm
authors.initials: AH
authors.lastname: Nielsen
authors.forename: Nanna
authors.initials: N
authors.lastname: Bjarnholt
authors.forename: Mika
authors.initials: M
authors.lastname: Zagrobelny
authors.forename: Søren
authors.initials: S
authors.lastname: Bak
authors.forename: Birger Lindberg
authors.initials: BL
authors.lastname: Møller
mesh_terms: D000470:Alkaloids / Q000096:biosynthesis; D004789:Enzyme Activation; D005419:Flavonoids / Q000096:biosynthesis; D006027:Glycosides / Q000096:biosynthesis; D007529:Isoflavones / Q000096:biosynthesis; D009097:Multienzyme Complexes / Q000378:metabolism*; D010944:Plants / Q000378:metabolism*; D013729:Terpenes / Q000378:metabolism
chemical_list: D000470:Alkaloids; D005419:Flavonoids; D006027:Glycosides; D007529:Isoflavones; D009097:Multienzyme Complexes; D013729:Terpenes; C007173:cyanogenic glycosides