A synthetic route to a novel type of conformationally constrained N-aryloxazolidinones.
The synthesis of N-aryloxazolidinone 1, a conformationally constrained analog of linezolid embodying a tricyclic pyrrolo[1,2-a][4,1]benzoxazepine moiety as the N-aryl substituent, is reported. The synthetic route involves the successive construction of the pyrrole, oxazepine, and oxazolidinone rings, with incorporation of the isoxazolylamino moiety in the last synthetic steps.
Griera
Rosa
R
Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, 0802-Barcelona, Spain.
Cantos-Llopart
Carme
C
Amat
Mercedes
M
Bosch
Joan
J
del Castillo
Juan-C
JC
Huguet
Joan
J
D008968:Molecular Conformation; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D023303:Oxazolidinones