title: Extraesophageal acid reflux and recurrent respiratory papilloma in children.
abstract: OBJECTIVE
  Recurrent respiratory papillomatosis (RRP) is a benign infectious disease which is caused by the human papilloma virus (HPV). When it infects the larynx, hoarseness and airway obstruction are often the presenting symptoms. Latent virus is found in the laryngeal mucosa of many more patients than exhibit the disease. The factors which lead to virus activation have not been identified, however, extra-esophageal acid reflux disease (EERD) has been suggested as one of these factors.
  
  
  METHODS
  This is a case series of four patients with RRP who had increase in severity of their disease with the recognition of concurrent extra-esophageal acid reflux. The clinical course of the papillomatosis and the diagnosis and treatment of reflux are compared over time.
  
  
  RESULTS
  In all four cases, with identification and treatment of the EERD, control of the RRP improved, and in at least two patients, was complete with resolution of the EERD. Lapses in compliance with medications or behavioral and dietary recommendations in three out of four patients led to a rebound in symptoms and signs of RRP, including worsening of vocal quality and the endoscopic appearance of the larynx.
  
  
  CONCLUSIONS
  The clinical course of these patients suggests a link between the presence of EERD and RRP. The inflammation induced by chronic acid exposure may result in the expression of HPV in susceptible tissues. Prompt diagnosis and effective treatment of EERD should be considered in all patients with difficult to control RRP or with clinical presentation or endoscopic signs of EERD.
authors.affiliation: Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA. margomckenna@meei.harvard.edu
authors.forename: Margo
authors.initials: M
authors.lastname: McKenna
authors.forename: Linda
authors.initials: L
authors.lastname: Brodsky
mesh_terms: D000402:Airway Obstruction / Q000209:etiology / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007822:Laryngeal Neoplasms / Q000150:complications* / Q000628:therapy / Q000821:virology; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000150:complications* / Q000628:therapy; D010212:Papilloma / Q000150:complications* / Q000628:therapy / Q000821:virology; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications / Q000628:therapy; D012720:Severity of Illness Index; D014412:Tumor Virus Infections / Q000150:complications / Q000628:therapy