title: A three-component photoreversible tag for thiols.
abstract: [structure: see text] A one-pot coupling of a 1,3-diketone, an aldehyde, and an alkanethiol has been developed to produce a protected sulfide. Through use of an o-nitrophenylbenzaldehyde, this method provides a one-step route to a photochemically reversible thiol-protecting group. The kinetics of photolysis were established using (1)H NMR analysis, which allows for the rate to be based on the entire reaction scheme.
authors.affiliation: Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, USA.
authors.forename: Kristine M
authors.initials: KM
authors.lastname: Clarke
authors.forename: James J
authors.initials: JJ
authors.lastname: La Clair
authors.forename: Michael D
authors.initials: MD
authors.lastname: Burkart