[Clinical value of neopterin. Part I].
Neopterin concentration can be used to detect the activation of the cellular immune system. Neopterin synthesis is the sum of all positive and negative regulating factors on the monocyte/macrophage populations activated by interferon-gamma, which is mainly produced by activated T lymphocytes. Neopterin can be determined in serum, plasma and other body fluids such as urine, cerebrospinal fluid, saliva, synovial fluid, ascitic fluid. The normal range of the neopterin concentration in serum or plasma is below 10 nmol/l. The applications for neopterin as a laboratory parameter for clinical diagnosis are: infections, autoimmune diseases, malignant diseases, posttransplant monitoring, blood transfusions, immunomodulatory therapy and treatment monitoring. Our own research results will be presented in part II of this study.
Plata-Nazar
Katarzyna
K
Klinika Pediatrii, Gastroenterologii i Onkologii, Dziecieca Akademia Medyczna, 80-803 Gdańsk, Poland.
Kozielska
Ewa
E
Łuczak
Grazyna
G
D001327:Autoimmune Diseases / Q000175:diagnosis / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism; D006801:Humans; D007107:Immune System / Q000378:metabolism; D007239:Infections / Q000378:metabolism; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism; D019798:Neopterin / Q000378:metabolism*
D015415:Biomarkers; D014408:Biomarkers, Tumor; D019798:Neopterin