The missing link: analogous human and primate cortical gamma oscillations.
Recent animal studies highlighting the relationship between functional imaging signals and the underlying neuronal activity have revealed the potential capabilities of non-invasive methods. However, the valuable exchange of information between animal and human studies remains restricted by the limited evidence of direct physiological links between species. In this study we used magnetoencephalography (MEG) to investigate the occurrence of 30-70 Hz (gamma) oscillations in human visual cortex, induced by the presentation of visual stimuli of varying contrast. These oscillations, well described in the animal literature, were observed in retinotopically concordant locations of visual cortex and show striking similarity to those found in primate visual cortex using surgically implanted electrodes. The amplitude of the gamma oscillations increases linearly with stimulus contrast in strong correlation with the gamma oscillations found in the local field potential (LFP) of the macaque. We demonstrate that non-invasive magnetic field measurements of gamma oscillations in human visual cortex concur with invasive measures of activation in primate visual cortex, suggesting both a direct representation of underlying neuronal activity and a concurrence between human and primate cortical activity.
Hall
Stephen D
SD
The Wellcome Trust Laboratory for MEG Studies, Neurosciences Research Institute, Aston University, Birmingham, UK. Hallsd@Aston.ac.uk
Holliday
Ian E
IE
Hillebrand
Arjan
A
Singh
Krish D
KD
Furlong
Paul L
PL
Hadjipapas
Avgis
A
Barnes
Gareth R
GR
D000465:Algorithms; D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D006801:Humans; D008251:Macaca; D008280:Magnetics; D015225:Magnetoencephalography; D010775:Photic Stimulation; D011323:Primates / Q000502:physiology*; D012160:Retina / Q000502:physiology; D013045:Species Specificity; D014793:Visual Cortex / Q000502:physiology