title: Mechanism of proliferation arrest of embryonic cells of Xenopus by diterpene compounds.
abstract: Three diterpene compounds isolated from the anti-cancer herbal medicine kansui, namely, kansuinin B, 20-OD-ingenol Z, and 20-OD-ingenol E, specifically inhibited the proliferation of isolated embryonic cells from Xenopus embryos. We conducted a cytologic study to determine the mechanism underlying the arrest of the cellular proliferation by these compounds. While kansuinin B and 20-OD-ingenol Z treatment decreased the cell numbers in the S phase and the M phase substages of the cell cycle, 20-OD-ingenol E inhibited mitosis.
authors.affiliation: Laboratory of Biochemistry, Department of Chemistry, College of Humanities and Sciences, Nihon University, 3-25-40 Sakurajosui, Setagaya-ku, Tokyo 156-8550, Japan.
authors.forename: Tomoharu
authors.initials: T
authors.lastname: Okouchi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Abe
authors.forename: Shusuke
authors.initials: S
authors.lastname: Araki
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Arai
authors.forename: Takashi
authors.initials: T
authors.lastname: Iida
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Wang
authors.forename: Susumu
authors.initials: S
authors.lastname: Kitanaka
authors.forename: Shohei
authors.initials: S
authors.lastname: Miyata
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D004224:Diterpenes / Q000494:pharmacology*; D005260:Female; D008297:Male; D016196:S Phase / Q000187:drug effects; D014982:Xenopus laevis / Q000196:embryology*
chemical_list: D004224:Diterpenes