title: Protective effects of an antioxidant derived from serine and vitamin B6 on skin photoaging in hairless mice.
abstract: The generation of reactive oxygen species (ROS) by ultraviolet radiation (UVR) accelerates skin aging, which is known as photoaging. Because cutaneous iron catalyzes ROS generation, sequestering iron by chelating agents is thought to be an effective approach toward preventing photoaging. Previously, N-(4-pyridoxylmethylene)-l-serine (PYSer) was designed as an antioxidant to suppress iron-catalyzed ROS generation by its iron-sequestering activity. In this study, PYSer showed protective effects against skin damage in hairless mice irradiated with ultraviolet B (UV-B). Topical application of PYSer to the skin significantly delayed and/or decreased the visible wrinkle formation induced by chronic UV-B irradiation. A histological study indicated that UV-B-induced epidermal hypertrophy and lymphocytic infiltration were suppressed by PYSer. Moreover, PYSer showed suppressive activity against the UV-B-induced increase in glycosaminoglycans (GAG). These results indicate that PYSer is a promising antioxidant for the prevention of chronic skin photoaging by its iron-sequestering activity.
authors.affiliation: AminoScience Laboratories, Ajinomoto Co., Inc., Kawasaki, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Kitazawa
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Ishitsuka
authors.forename: Misako
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakano
authors.forename: Keiji
authors.initials: K
authors.lastname: Iwasaki
authors.forename: Kazutami
authors.initials: K
authors.lastname: Sakamoto
authors.forename: Kumi
authors.initials: K
authors.lastname: Arakane
authors.forename: Tadashi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Lorraine H
authors.initials: LH
authors.lastname: Kligman
mesh_terms: D000818:Animals; D005260:Female; D051379:Mice; D008812:Mice, Hairless; D012694:Serine / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects / Q000254:growth & development* / Q000528:radiation effects*; D015595:Skin Aging / Q000187:drug effects* / Q000528:radiation effects; D025101:Vitamin B 6 / Q000494:pharmacology*
chemical_list: D012694:Serine; D025101:Vitamin B 6