title: Noninvasive assessment of coronary artery stenoses by multidetector-row spiral computed tomography: comparison with conventional angiography.
abstract: BACKGROUND
  Coronary artery disease (CAD) is the most common cause of hospitalization and mortality in many industrialized countries. We analysed the diagnostic accuracy of multi-detector row spiral computed tomography (MDCT) in determining mid- to high-grade coronary artery stenoses (> 50%).
  
  
  METHODS
  Sixty-nine patients with suspected CAD were referred to MDCT coronary angiography. Patients with a heart rate above 60 bpm received 20-40 mg propranol before the scan. The left main (LM), the left anterior descending artery (LAD), the first diagonal branch (D1), the right coronary artery (RCA) and the proximal tract of the circumflex artery (LCX) were independently evaluated by two blinded observers and screened for > 50% stenoses. The mean values of MDCT coronary narrowings assessed by two observers were compared to quantitative coronary angiography.
  
  
  RESULTS
  MDCT correctly detected 95 of 123 coronary lesions (sensitivity 77.2%) and absence of stenoses was correctly identified in 388 of 426 segments (specificity 91%). The sensitivity for the LM, LAD, RCA and the proximal tract of LCX was 100%, 86.5%, 69.8% and 80% respectively. Classification of patients as having 1-vessel, 2-vessels, 3-vessels or left main disease was accurate in 75.4% (46/61) of patients.
  
  
  CONCLUSIONS
  MDCT technology, combined with heart rate control, allows reliable noninvasive detection of hemodynamically significant CAD.
authors.affiliation: Department of Cardiovascular and Respiratory Sciences, "La Sapienza" University of Rome (Italy).
authors.forename: C
authors.initials: C
authors.lastname: Gaudio
authors.forename: F
authors.initials: F
authors.lastname: Mirabelli
authors.forename: L
authors.initials: L
authors.lastname: Alessandrà
authors.forename: B L
authors.initials: BL
authors.lastname: Nguyen
authors.forename: S
authors.initials: S
authors.lastname: Di Michele
authors.forename: F
authors.initials: F
authors.lastname: Corsi
authors.forename: G
authors.initials: G
authors.lastname: Tanzilli
authors.forename: M
authors.initials: M
authors.lastname: Mancone
authors.forename: G
authors.initials: G
authors.lastname: Pannarale
authors.forename: M
authors.initials: M
authors.lastname: Francone
authors.forename: I
authors.initials: I
authors.lastname: Carbone
authors.forename: C
authors.initials: C
authors.lastname: Catalano
authors.forename: R
authors.initials: R
authors.lastname: Passariello
authors.forename: F
authors.initials: F
authors.lastname: Fedele
mesh_terms: D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000000981:diagnostic imaging*; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D036542:Tomography, Spiral Computed