Synthesis of thiosemicarbazone and 4-thiazolidinone derivatives and their in vitro anti-Toxoplasma gondii activity.
Thiosemicarbazone and 4-thiazolidinone derivatives were synthesized in one and two step, respectively, from thiosemicarbazide, in satisfactory yields. Then, the synthesized compounds were submitted to evaluation against host cells infected with Toxoplasma gondii. The present studies showed that thiosemicarbazones 2 and 4-thiazolidinone derivatives 3 were effective against intracellular T. gondii.
Tenório
Rômulo P
RP
Departamento de Antibióticos, Universidade Federal de Pernambuco, Recife 50670-901, Brazil.
Carvalho
Cristiane S
CS
Pessanha
Carla S
CS
de Lima
José G
JG
de Faria
Antônio R
AR
Alves
Antônio J
AJ
de Melo
Edésio J T
EJ
Góes
Alexandre J S
AJ
D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014122:Toxoplasma / Q000187:drug effects*; D014709:Vero Cells
D000981:Antiprotozoal Agents; D013844:Thiazoles; D013882:Thiosemicarbazones