title: [A case of pulmonary intravascular lymphoma treated with CHOP chemotherapy plus rituximab].
abstract: We report a case of pulmonary intravascular lymphoma of large B cell type in a 72-year-old woman. She had a one-month history of fever and dry cough before admission. Chest X-ray revealed ground glass shadow in both lung fields, and the high-resolution CT disclosed centrilobular distribution of ground glass opacities. Transbronchial lung biopsy demonstrated large lymphoid cells in the capillaries of alveolar septa. The tumor cells showed strong immunohistochemical reactivity to CD 20. After combined treatment with CHOP and rituximab, clinical symptoms, laboratory and radiological findings were improved. As with diffuse large B cell lymphoma, CHOP chemotherapy plus rituximab may prove useful as a standard regimen for pulmonary intravascular lymphoma.
authors.affiliation: First Dept of Internal Medicine, Tokyo Medical University.
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Ohkubo
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Yoshida
authors.forename: Kaori
authors.initials: K
authors.lastname: Ohta
authors.forename: Tomoiku
authors.initials: T
authors.lastname: Takaku
authors.forename: Tomoko
authors.initials: T
authors.lastname: Katagiri
authors.forename: Jinho
authors.initials: J
authors.lastname: Paku
authors.forename: Ikuma
authors.initials: I
authors.lastname: Kasuga
authors.forename: Kazushige
authors.initials: K
authors.lastname: Minemura
authors.forename: Akihiko
authors.initials: A
authors.lastname: Gotoh
authors.forename: Hiromi
authors.initials: H
authors.lastname: Serizawa
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Mukai
authors.forename: Kazuma
authors.initials: K
authors.lastname: Ohyashiki
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D058846:Antibodies, Monoclonal, Murine-Derived; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008168:Lung / Q000098:blood supply*; D016393:Lymphoma, B-Cell / Q000188:drug therapy*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy*; D011239:Prednisolone / Q000008:administration & dosage; D012074:Remission Induction; D000069283:Rituximab; D019043:Vascular Neoplasms / Q000188:drug therapy*; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone