title: A prospective study of outcome predictors after severe brain injury in children.
abstract: OBJECTIVE
  To directly compare the predictive powers of somatosensory evoked potentials (SEPs) to those of motor and pupillary responses.
  
  
  METHODS
  Prospective clinical study in a paediatric intensive care unit.
  
  
  METHODS
  102 severely brain-injured children less than 15 years of age.
  
  
  RESULTS
  SEPs and motor and pupillary responses were serially recorded during the first 9 days after admission. Initial, last and those tests performed on or after day 2 were analysed. Outcome was assessed 5 years after injury. SEPs had equal or superior predictive statistics and ROC curves compared to the other tests with few exceptions. Pupillary responses had higher sensitivity for favourable outcome prediction while for unfavourable outcome prediction the last motor responses had higher sensitivity, and the last pupillary responses had slightly higher specificity. Combining SEPs and motor responses provided the best combination for predicting unfavourable outcome.
  
  
  CONCLUSIONS
  SEPs are the best overall predictor of outcome while motor and pupillary responses have advantages in some specific areas. The routine use of SEPs should be considered in the prediction of outcome of severely brain-injured patients.
authors.affiliation: Paediatric Intensive Care Unit, Royal Children's Hospital, 3052 Parkville, Melbourne, VIC, Australia. icu.tech@rch.org.au
authors.forename: B G
authors.initials: BG
authors.lastname: Carter
authors.forename: W
authors.initials: W
authors.lastname: Butt
mesh_terms: D000293:Adolescent; D001930:Brain Injuries / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D005073:Evoked Potentials, Somatosensory; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009460:Neurologic Examination; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve; D012025:Reflex, Pupillary