[Expression of brain-derived neurotrophic factor in hippocampus of ovariectomized mouse].
OBJECTIVE
To explore the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus after ovariectomy in mice.


METHODS
BDNF levels were detected by immunohistochemistry combined image analysis in hippocampal CA regions and dentate gyrus of ovariectomized mice.


RESULTS
The expression of BDNF in hippocampus of mice decreased significantly after the ovariectomy after 4 days. The recovery BDNF expression started 14 days after the ovariectomy and after 28 days, the expression of BDNF in hippocampus recovered to the normal level.


CONCLUSIONS
The decrease of estrogen in ovariectomized mice can weaken the expression of BDNF in hippocampus during the early stage.
Lu
Da-hua
DH
Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha 410013, China.
Yang
De-sen
DS
Liu
Dan
D
Li
Chang-qi
CQ
Luo
Xue-gang
XG
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000096:biosynthesis* / Q000235:genetics; D018891:Dentate Gyrus / Q000378:metabolism; D004967:Estrogens / Q000097:blood; D005260:Female; D006624:Hippocampus / Q000378:metabolism*; D051379:Mice; D010052:Ovariectomy; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics
D019208:Brain-Derived Neurotrophic Factor; D004967:Estrogens; D012333:RNA, Messenger