title: Complete response of brain metastases to irinotecan-based chemotherapy.
abstract: Brain metastases occur in 15-20% of patients with cancer and are generally associated with an overall poor prognosis. Currently, radiotherapy and surgery are the mainstay of palliative therapy for patients with brain metastases, while the role of systemic chemotherapy remains uncertain. In this article, we report complete responses to irinotecan-based chemotherapy in three patients with brain metastases from parotid adenocarcinoma, esophageal adenocarcinoma and small cell lung cancer. Irinotecan-based chemotherapy may hold promise in treating patients with brain metastases. Further studies are warranted to confirm our observations.
authors.affiliation: Department of Radiation Oncology, University of California, Davis Memorial Center, Sacramento, CA 95817, USA. rachel.chou@ucdmc.ucdavis.edu
authors.forename: Rachel
authors.initials: R
authors.lastname: Chou
authors.forename: Allan
authors.initials: A
authors.lastname: Chen
authors.forename: Derick
authors.initials: D
authors.lastname: Lau
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D018288:Carcinoma, Small Cell / Q000473:pathology / Q000601:surgery; D004938:Esophageal Neoplasms / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D000077146:Irinotecan; D008175:Lung Neoplasms / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000473:pathology / Q000601:surgery
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000077146:Irinotecan; D002166:Camptothecin