Clustered DNA damage induced by heavy ion particles.
Clustered DNA damage (locally multiply damaged site) is thought to be a critical lesion caused by ionizing radiation, and high LET radiation such as heavy ion particles is believed to produce high yields of such damage. Since heavy ion particles are major components of ionizing radiation in a space environment, it is important to clarify the chemical nature and biological consequences of clustered DNA damage and its relationship to the health effects of exposure to high LET particles in humans. The concept of clustered DNA damage emerged around 1980, but only recently has become the subject of experimental studies. In this article, we review methods used to detect clustered DNA damage, and the current status of our understanding of the chemical nature and repair of clustered DNA damage.
Terato
Hiroaki
H
Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi-Hiroshima, Japan. hterato@hiroshima-u.ac.jp
Ide
Hiroshi
H
D003359:Cosmic Radiation; D004249:DNA Damage / Q000502:physiology* / Q000528:radiation effects*; D045647:DNA Glycosylases; D004260:DNA Repair / Q000502:physiology* / Q000528:radiation effects*; D016521:Electrophoresis, Gel, Pulsed-Field; D004720:Endonucleases / Q000528:radiation effects; D020450:Heavy Ions; D006801:Humans; D017665:Hydroxyl Radical; D018499:Linear Energy Transfer; D011829:Radiation Dosage; D011839:Radiation, Ionizing
D017665:Hydroxyl Radical; D004720:Endonucleases; D045647:DNA Glycosylases