title: [The identification of multiple thrombophilic risk factors in an infant with cerebrovascular accident].
abstract: BACKGROUND
  Neonatal stroke (NNS) incidence appears to be increasing over the last years. This is believed to be a consequence of diagnostic accuracy rather than a real amplification of this entity. Nowadays, NNS incidence is estimated to be 1:4000 full newborns.
  
  
  METHODS
  Child with left middle cerebral artery territory infarction in which several thromboembolic risk factors were documented both in the child (neonatal sepsis and factor V Leiden) and his mother (lupus anticoagulant, pre-eclampsy and factor V Leiden).
  
  
  CONCLUSIONS
  This case supports the increasing evidence in recent reports that association of multiple prothrombotic risk factors (maternal and foetal) is present in NNS genesis. This way the authors agree that wide prothrombotic study may be of crucial interest in identifying subjacent thrombophilic disease, even when an exogenous risk factor is present.
authors.affiliation: Servicio de Hematología, Hospital de Crianças Maria Pia, 4050-111 Porto, Portugal.
authors.forename: J
authors.initials: J
authors.lastname: Neves
authors.forename: E
authors.initials: E
authors.lastname: Costa
authors.forename: R
authors.initials: R
authors.lastname: Branca
authors.forename: I
authors.initials: I
authors.lastname: Carrilho
authors.forename: J
authors.initials: J
authors.lastname: Barbot
authors.forename: C
authors.initials: C
authors.lastname: Barbot
mesh_terms: D002675:Child, Preschool; D005165:Factor V; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D020244:Infarction, Middle Cerebral Artery / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D008297:Male; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology; D019851:Thrombophilia / Q000150:complications* / Q000175:diagnosis / Q000473:pathology
chemical_list: C095381:factor V Leiden; D005165:Factor V