Do statins increase the risk of idiopathic polyneuropathy?
A recent European case-control study suggested that statins increase the risk for polyneuropathy, a rare but serious neurologic condition. This risk was assessed in 272 patients with idiopathic polyneuropathy and 1,360 matched controls in the Intermountain Health Care electronic database. It was found that statin use before diagnosis was not significantly greater in patients than controls (odds ratio 1.30, 95% confidence interval 0.3 to 2.1, p = 0.27), nor were doses different between patients and controls.
Anderson
Jeffrey L
JL
Cardiovascular Department, LDS Hospital, Cardiology Division, Intermountain Health Care, Salt Lake City, Utah 84143, USA. jeffrey.anderson@ihc.com
Muhlestein
Joseph B
JB
Bair
Tami L
TL
Morris
Steven
S
Weaver
Aaron N
AN
Lappé
Donald L
DL
Renlund
Dale G
DG
Pearson
Robert R
RR
Jensen
Kurt R
KR
Horne
Benjamin D
BD
D016022:Case-Control Studies; D016208:Databases, Factual; D019033:Delivery of Health Care, Integrated; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D007345:Insurance Claim Review; D008297:Male; D008875:Middle Aged; D011115:Polyneuropathies / Q000139:chemically induced*; D018570:Risk Assessment; D012307:Risk Factors; D014589:Utah
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors