Siberian ginseng reduces infarct volume in transient focal cerebral ischaemia in Sprague-Dawley rats.
Siberian ginseng, the root and stem bark of Acanthopanax senticosus Harms, has been used as a tonic and adaptogen to strengthen qi in traditional Korean medicine. The neuroprotective effects of water extracts of A. senticosus (ASW) were investigated in transient middle cerebral artery occlusion (MCAo, 90 min occlusion, 24 h reperfusion) of Sprague-Dawley rats. The infarct volume was significantly reduced by 36.6% after the peritoneal injection of ASW (100 mg[sol ]kg) compared with the control. In the immunohistochemical study, ASW markedly inhibited both cyclooxygenase-2 and OX-42 expressions in the penumbral region at 24 h after MCAo. These results suggest that A. senticosus has a neuroprotective effect by inhibiting inflammation and microglial activation in brain ischaemia.
Bu
Yungmin
Y
Department of Herbal Pharmacology, Graduate School of East-West Medical Science KyungHee University, Seoul, South Korea.
Jin
Zhen Hua
ZH
Park
Sun Young
SY
Baek
Sunkyung
S
Rho
Sungju
S
Ha
Nina
N
Park
Seong Kyu
SK
Kim
Hocheol
H
D000818:Animals; D002545:Brain Ischemia / Q000201:enzymology; D002540:Cerebral Cortex / Q000098:blood supply; D002544:Cerebral Infarction / Q000517:prevention & control; D028001:Eleutherococcus; D006801:Humans; D007274:Injections, Intraperitoneal; D020768:Middle Cerebral Artery / Q000503:physiopathology; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D018547:Plant Stems; D051381:Rats; D017207:Rats, Sprague-Dawley
D018696:Neuroprotective Agents; D010936:Plant Extracts