Reversible dilated cardiomyopathy associated with amphotericin B treatment.
We report two patients, who developed dilated cardiomyopathy and subsequent congestive heart failure after treatment with amphotericin B (AmB). The echocardiographic findings and the symptoms of heart failure resolved after the discontinuation of the drug. The clinical data from our cases and two similar cases reported in the literature suggest that the presence of other factors predisposing to cardiac dysfunction may facilitate the occurrence of this rare side effect.
Moyssakis
Ioannis
I
Department of Cardiology, Laikon General Hospital, Athens, Greece.
Vassilakopoulos
Theodoros P
TP
Sipsas
Nikolaos V
NV
Perakis
Alexandros
A
Petrou
Alexandra
A
Kosmas
Nikolaos
N
Pangalis
Gerassimos A
GA
D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage / Q000009:adverse effects*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002177:Candidiasis / Q000188:drug therapy; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D052776:Female Urogenital Diseases / Q000188:drug therapy / Q000382:microbiology; D005334:Fever / Q000188:drug therapy; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D052801:Male Urogenital Diseases; D008875:Middle Aged; D028761:Withholding Treatment
D000935:Antifungal Agents; D000666:Amphotericin B