[Cardiovascular disease in Chinese chronic renal insufficiency patients-epidemiology survey].
OBJECTIVE
Cardiovascular (CV) disease (CVD) is the single most important cause of death among Chinese dialysis patients, accounting for 51% of overall mortality. The study was performed to investigate the prevalence and the spectrum of CVD in Chinese chronic kidney disease (CKD) patients.


METHODS
The multicenter Chinese cohort study examined 1239 CKD patients from 7 main medical centers (distributed in 5 regions of China) who were hospitalized between 2002 and 2003.


RESULTS
(1) The most prevalent pathological form of CVD was left ventricular (LV) hypertrophy (LVH), accounting for 58.5% of total patients. The prevalence of coronary artery disease (CAD), congestive heart failure (CHF), and cerebrovascular accidents (CVA) was 16.5%, 27.7% and 5.6%, separately. (2) The cohort with minor renal dysfunction (stage 2-3) had higher prevalence of CAD (5.9%) and CVA (1.0%) compared with general population in the same regions. Up to 41.2% of minor CKD patients were complicated with LVH, and 13.8% of them had clinical evidence of CHF. The prevalence of CAD, LVH and CHF increased as glomerular filtration decline. (3) The prevalence of CAD (20.0%) was much lower and the prevalence of CVA (5.4%) was higher in Chinese dialysis patients than that in American dialysis population. There was significant geographical variations in CAD prevalence, but it was not different between genders.


CONCLUSIONS
The CV risk is significantly increased in patients with CKD. Even minor CKD has a major impact on the CV risk. The prevalence of CAD in Chinese dialysis patients is markedly lower than that in American dialysis population.
Hou
Fan-Fan
FF
Department of Nephrology, Nanfang Hospital, Guangzhou 510515, China.
Ma
Zhi-Gang
ZG
Mei
Chang-Lin
CL
Rong
Shu
S
Huang
Song-Min
SM
Liu
Xian-Rong
XR
Yuan
Wei-Jie
WJ
Guo
Yun-Shan
YS
Wang
Li
L
He
Qiang
Q
Wang
Xiu-Ling
XL
Sang
Xiao-Hong
XH
Li
Xiao-Li
XL
D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000150:complications / Q000453:epidemiology*; D002561:Cerebrovascular Disorders / Q000150:complications / Q000453:epidemiology; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D003327:Coronary Disease / Q000150:complications / Q000453:epidemiology; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000453:epidemiology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications / Q000453:epidemiology*; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000453:epidemiology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D006435:Renal Dialysis; D012307:Risk Factors