Capacitative calcium entry: sensing the calcium stores.
A long-standing mystery in the cell biology of calcium channel regulation is the nature of the signal linking intracellular calcium stores to plasma membrane capacitative calcium entry channels. An RNAi-based screen of selected Drosophila genes has revealed that a calcium-binding protein, stromal interaction molecule (STIM), plays an essential role in the activation of these channels and may be the long sought sensor of calcium store content.
Putney
James W
JW
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health Department of Health and Human Services, Research Triangle Park, NC 27709, USA. putney@niehs.nih.gov
D000818:Animals; D006801:Humans; D015220:Calcium Channels / Q000235:genetics / Q000378:metabolism; D020013:Calcium Signaling / Q000502:physiology; D002135:Calcium-Binding Proteins / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism / Q000648:ultrastructure; D029721:Drosophila Proteins / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics; D009363:Neoplasm Proteins / Q000235:genetics; D017434:Protein Structure, Tertiary / Q000502:physiology; D000071737:Stromal Interaction Molecule 1
D015220:Calcium Channels; D002135:Calcium-Binding Proteins; D029721:Drosophila Proteins; D008565:Membrane Proteins; D009363:Neoplasm Proteins; C103530:STIM1 protein, human; D000071737:Stromal Interaction Molecule 1