A functional genomics approach to identify new regulators of Wnt signaling.
A recent study by used a genome-wide RNAi screen in Drosophila cells to identify 238 candidate regulators of the Wnt-signaling pathway, most of which had not been previously connected to Wnt signaling. Supporting in vivo studies are in progress. The fact that such an impressive number of potential modulators had eluded detection in genetic screens underscores the potential of applying new, high-throughput approaches to old problems.
Furlong
Eileen E
EE
Developmental Biology Programme and Gene Expression Programme, European Molecular Biology Laboratory, Heidelberg, Germany.
D000818:Animals; D004330:Drosophila / Q000235:genetics / Q000254:growth & development / Q000502:physiology; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology; D023281:Genomics / Q000379:methods*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics* / Q000502:physiology*; D015398:Signal Transduction; D014158:Transcription, Genetic; D051153:Wnt Proteins
D029721:Drosophila Proteins; D036341:Intercellular Signaling Peptides and Proteins; D051153:Wnt Proteins