title: Orthotopic liver transplantation in U.S. veterans under primary tacrolimus immunosupression.
abstract: The evolution and refinement of surgical techniques, per ioperative patient care, and immunosuppression hav~ estab~ished orthoto~ic li~er transplantation (OLTX) as a ~ighly successful therapeutic modality for patients wrth end-stage hver disease. In February 1989,Tacrohmus (Prograf®, formerly FK 506)was first used successfully at the University of Pittsburgh Medical Center to treat patients with rejection refractory to cyclosporine-based immunosuppression." Clinical trials utilizing Tacrolimus in solid organ transplantation followed, and in April of 1994 it was approved for use by the Food and Drug Administration,
authors.affiliation: Pittsburgh Transplantation Institute and the Vetrans Administration Medical Center, Pittsburgh, Pennsylvania, USA.
authors.forename: T
authors.initials: T
authors.lastname: Gayowski
authors.forename: I R
authors.initials: IR
authors.lastname: Marino
authors.forename: N
authors.initials: N
authors.lastname: Singh
authors.forename: H R
authors.initials: HR
authors.lastname: Doyle
authors.forename: M M
authors.initials: MM
authors.lastname: Wagener
authors.forename: S
authors.initials: S
authors.lastname: Todo
authors.forename: J J
authors.initials: JJ
authors.lastname: Fung
authors.forename: T E
authors.initials: TE
authors.lastname: Starzl