title: In vitro study of the adsorption characteristics of drugs.
abstract: The adsorption characteristics of eight adsorbents, cholestyramine, colestimide, aluminum silicate, sucralfate, aluminum hydroxide, calcium polystyrene sulfonate, carbon sphere and medicinal carbon, on the drugs such as methotrexate, antidepressants, mizoribine and ciprofloxacin hydrochloride were investigated in vitro. Medicinal carbon showed an excellent adsorption of all the tested drugs while the carbon spheres showed a high but slow adsorption characteristic. Cholestyramine and colestimide showed a higher adsorption in methotrexate than the other adsorbents. Aluminum silicate and calcium polystyrene sulfonate showed higher adsorption in four antidepressants, clomipramine hydrochloride, imipramine hydrochloride, mianserin hydrochloride and trazodone hydrochloride. In mizoribine, there were no adsorbents that showed higher adsorption except for the medicinal carbon. In ciprofloxacin hydrochloride, aluminum preparations and calcium polystyrene sulfonate showed higher adsorption characteristics. It is suggested that several adsorbents are potentially useful treatments for drug overdoses, but that these adsorbents have the possibility of decreasing the effects of the co-administered medicines.
authors.affiliation: Department of Pharmacy, Yamagata University Hospital, Yamagata 990-8585, Japan. tteiko@med.id.yamagata-u.ac.jp
authors.forename: Teiko
authors.initials: T
authors.lastname: Toyoguchi
authors.forename: Mitsutaka
authors.initials: M
authors.lastname: Ebihara
authors.forename: Fumiyoshi
authors.initials: F
authors.lastname: Ojima
authors.forename: Jun
authors.initials: J
authors.lastname: Hosoya
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Nakagawa
mesh_terms: D000327:Adsorption; D002244:Carbon / Q000032:analysis / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000378:metabolism*
chemical_list: D004364:Pharmaceutical Preparations; D002244:Carbon