A quantitative appraisal of interference by icodextrin metabolites in point-of-care glucose analyses.
An important number of patients dependent on renal dialysis prefer peritoneal dialysis to hemodialysis. In the case of peritoneal dialysis, the glucose polymer icodextrin is frequently added to the dialysis fluid as an osmotic agent, since this polymer is able to maintain an osmotic gradient across the peritoneal membrane longer than monomeric glucose, leading to a prolonged effective ultrafiltration time. It was previously shown that icodextrin is partly able to enter the blood via the lymphatic system, where hydrolysis to glucose oligomers such as maltose and maltotriose occurs. The presence of these oligomers in the blood appears to cause significant overestimations of the glucose values in several point-of-care (POC) glucose analyzers, with potentially dramatic consequences. This effect has been investigated for a series of POC glucose analyzers, both by analyzing the blood of peritoneal dialysis patients and by an in vitro investigation of the quantitative effects of maltose and maltotriose. In particular, POC analyzers utilizing the bacterially produced enzyme glucose dehydrogenase seem to lack glucose specificity.
Apperloo
Joke J
JJ
Laboratory for Clinical Chemistry, Máxima Medical Center, Veldhoven, The Netherlands. j.apperloo@mmc.nl
Vader
Huib L
HL
D016477:Artifacts; D001774:Blood Chemical Analysis / Q000295:instrumentation*; D001786:Blood Glucose / Q000032:analysis*; D005936:Glucans / Q000378:metabolism* / Q000627:therapeutic use*; D005947:Glucose / Q000378:metabolism* / Q000627:therapeutic use*; D006801:Humans; D006868:Hydrolysis; D000077607:Icodextrin; D008320:Maltose / Q000378:metabolism / Q000627:therapeutic use; D010530:Peritoneal Dialysis / Q000379:methods; D019095:Point-of-Care Systems / Q000592:standards / Q000706:statistics & numerical data; D015203:Reproducibility of Results; D014312:Trisaccharides / Q000378:metabolism / Q000627:therapeutic use
D001786:Blood Glucose; D005936:Glucans; D014312:Trisaccharides; D000077607:Icodextrin; C008317:maltotriose; D008320:Maltose; D005947:Glucose