A hypothetical protein of Streptococcus mutans is critical for biofilm formation.
Inactivation of the Smu0630 gene of Streptococcus mutans resulted in dramatic decreases in biofilm formation, regardless of the carbohydrate source. The Smu0630 protein contained numerous interesting features, including a possible signal sequence and two conserved regions of repeated sequences. Smu0630 may represent a potential target for novel therapeutics.
Brown
Thomas A
TA
Department of Oral Biology, University of Florida College of Dentistry, 1600 SW Archer Rd., Gainesville, FL 32610-0424, USA.
Ahn
Sang-Joon
SJ
Frank
Roslyn N
RN
Chen
Yi-Ywan M
YY
Lemos
José A
JA
Burne
Robert A
RA
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D018441:Biofilms / Q000254:growth & development*; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D008855:Microscopy, Electron, Scanning; D008969:Molecular Sequence Data; D013295:Streptococcus mutans / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism
D001426:Bacterial Proteins; C500906:Smu0630 protein, Streptococcus mutans