title: Direct catalytic synthesis of enantiopure 5-substituted oxazolidinones from racemic terminal epoxides.
abstract: A venerable scaffold for asymmetric synthesis and drug development, chiral 5-substituted oxazolidinones are obtained in almost enantiomerically pure form (up to 99.9% ee) starting from racemic terminal epoxides. The salient features of this process include the very simple and convenient experimental protocol and the employment of a readily accessible catalyst and inexpensive, easily handled starting materials. An enantioconvergent approach for the total conversion of racemic epoxide into a single stereoisomeric oxazolidinone is also described.
authors.affiliation: Department of Organic Chemistry A. Mangini, University of Bologna, Italy. giuseppe.bartoli@unibo.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bartoli
authors.forename: Marcella
authors.initials: M
authors.lastname: Bosco
authors.forename: Armando
authors.initials: A
authors.lastname: Carlone
authors.forename: Manuela
authors.initials: M
authors.lastname: Locatelli
authors.forename: Paolo
authors.initials: P
authors.lastname: Melchiorre
authors.forename: Letizia
authors.initials: L
authors.lastname: Sambri