Antifungal properties of surangin B, a coumarin from Mammea longifolia.
The natural product electron transport inhibitor surangin B was examined for its ability to inhibit in vitro mycelial growth and spore germination in several species of fungi. As an inhibitor of mycelial growth, surangin B showed strongest activity against Rhizoctonia solani (IC50 = 3.8 microM) and Botrytis cinerea (IC50 = 11.2 microM). Inhibitory effects were less pronounced in Alternaria dauci, Fusarium oxysporum and Penicillium sp. (IC50 values > 30 microM) and absent in Trichoderma harzianum. Surangin B reduced the level of spore germination in Fusarium oxysporum (IC50 = 2.3 microM) and Botrytis cinerea (IC50 = 1.4 microM), although Alternaria dauci was considerably more tolerant of this coumarin (IC50 = 500 microM). Our results indicate that surangin B may have potential as an antifungal agent.
Deng
Yanshen
Y
Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
Nicholson
Russell A
RA
D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D031252:Mammea; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000935:Antifungal Agents; D010936:Plant Extracts