Use of a tacrolimus-eluting stent to inhibit neointimal hyperplasia in a porcine coronary model.
In-stent restenosis remains an unresolved problem which occurs in 5-20% of patients undergoing coronary stenting within the first 3-6 months. Neointimal formation is the main contributor to in-stent restenosis. Stent-induced arterial injury and peri-strut inflammation are involved in the process of neointimal formation by activating cytokines and growth factors which induce smooth muscle cell dedifferentiation, migration, and proliferation. Histopathological studies found that neointimal hyperplasia is principally composed of smooth muscle cells, inflammatory cells, and extracellular matrix. Stent-based delivery of anti-proliferative and/or anti-inflammatory agents have shown beneficial effects on neointimal hyperplasia in experimental studies and clinical trials. Tacrolimus (FK506) is a water-insoluble macrolide immunosuppressant discovered in 1984. It has been widely used in reducing the incidence and severity of allograft rejection after organ transplantation. It has also been used to treat other inflammatory conditions such as atopic dermatitis. In this study, we evaluated the efficacy of stent-based delivery of tacrolimus on inflammation and neointimal formation in an overstretched coronary stent model.
Huang
Yanming
Y
Department of Cardiology, University of Leuven, U.Z. Gasthuisberg O/N, Herestraat 49, Leuven 3000, Belgium. yanming.huang@med.kuleuven.ac.be
Salu
Koen
K
Wang
Lan
L
Liu
Xiaoshun
X
Li
Shengqiao
S
Lorenz
Gunter
G
Wnendt
Stephan
S
Verbeken
Eric
E
Bosmans
Johan
J
Van de Werf
Frans
F
De Scheerder
Ivan
I
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D020099:Coated Materials, Biocompatible; D023903:Coronary Restenosis / Q000473:pathology / Q000517:prevention & control*; D003331:Coronary Vessels / Q000187:drug effects / Q000473:pathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage; D015607:Stents; D013552:Swine; D016559:Tacrolimus / Q000008:administration & dosage*; D017539:Tunica Intima / Q000187:drug effects* / Q000473:pathology
D020099:Coated Materials, Biocompatible; D007166:Immunosuppressive Agents; D017239:Paclitaxel; D016559:Tacrolimus