Postoperative hyperthermia of unknown origin treated with dantrolene sodium.
An 11-year-old girl was scheduled for alveolar cleft bone grafting with an iliac bone under general anesthesia. Anesthesia was performed with 70% nitrous oxide, 30% oxygen, and propofol. On the first and second postoperative day, persistent hyperthermia was observed. Because the administration of diclofenac sodium had not been effective for the hyperthermia, dantrolene sodium was given. Her body temperature gradually dropped and returned to normal level on the fifth postoperative day. The hyperthermia in the present case might have been caused by a rapidly elevated muscle metabolism in response to pain and stress after the propofol anesthesia. The oral administration of dantrolene sodium successfully lowered the patient's high body temperature.
Inada
Hirohito
H
Section of Anesthesiology and Clinical Physiology, Department of Oral Restitution, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan. inada.anph@tmd.ac.jp
Jinno
Shigeharu
S
Kohase
Hikaru
H
Fukayama
Haruhisa
H
Umino
Masahiro
M
D000539:Alveolar Process / Q000002:abnormalities; D000543:Alveoloplasty; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001831:Body Temperature / Q000187:drug effects; D016025:Bone Transplantation; D002648:Child; D003620:Dantrolene / Q000627:therapeutic use*; D004008:Diclofenac / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008305:Malignant Hyperthermia / Q000188:drug therapy*; D009125:Muscle Relaxants, Central / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009125:Muscle Relaxants, Central; D004008:Diclofenac; D003620:Dantrolene