Influence of interleukin-10 on Aspergillus fumigatus infection in patients with cystic fibrosis.
Recent evidence suggests that genetic polymorphisms that affect the production of interleukin (IL)-10 may play a role in the response to pathogens in cystic fibrosis (CF). The present study was designed to investigate a possible association between alleles carried at position -1082 in the promoter region of the IL-10 gene and clinical data on 378 patients with CF. After adjustment for potential confounding variables, a significant relationship was found between the -1082GG genotype and both colonization with Aspergillus fumigatus and allergic bronchopulmonary aspergillosis. In addition, higher serum levels of IL-10 were observed in patients colonized with A. fumigatus. These results suggest that polymorphisms in the promoter region of the IL-10 gene may influence the host response to A. fumigatus in the context of CF.
Brouard
Jacques
J
Inserm E213, Armand Trousseau Hospital, Paris, and the Department of Pediatrics, Georges Clemenceau Hospital, Caen, France. brouard-j@chu-caen.fr
Knauer
Nicola
N
Boelle
Pierre-Yves
PY
Corvol
Harriet
H
Henrion-Caude
Alexandra
A
Flamant
Cyril
C
Bremont
François
F
Delaisi
Bertrand
B
Duhamel
Jean-Francois
JF
Marguet
Christophe
C
Roussey
Michel
M
Miesch
Marie-Claude
MC
Chadelat
Katarina
K
Boule
Michele
M
Fauroux
Brigitte
B
Ratjen
Felix
F
Grasemann
Hartmut
H
Clement
Annick
A
D000293:Adolescent; D001228:Aspergillosis / Q000276:immunology*; D001232:Aspergillus fumigatus; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008172:Lung Diseases, Fungal / Q000276:immunology*; D011110:Polymorphism, Genetic / Q000276:immunology*
D016753:Interleukin-10