title: Galectin-1 receptors in different cell types.
abstract: Galectins are a family of animal lectins defined by two properties: shared amino acid sequences in their carbohydrate-recognizing domain, and beta-galactoside affinity. A wide variety of biological phenomena are related to galectins, i.e., development, differentiation, morphogenesis, tumor metastasis, apoptosis, RNA splicing, and immunoregulatory function. In this review, we will focus on galectin-1 receptors, and some of the mechanisms by which this lectin affects different cell types. Several galectin-1 receptors are discussed such as CD45, CD7, CD43, CD2, CD3, CD4, CD107, CEA, actin, extracellular matrix proteins such as laminin and fibronectin, glycosaminoglycans, integrins, a beta-lactosamine glycolipid, GM1 ganglioside, polypeptide HBGp82, glycoprotein 90 K/MAC-2BP, CA125 cancer antigen, and pre-B cell receptor.
authors.affiliation: Fundación Instituto Leloir, Instituto de Investigaciones Bioquímicas de Buenos Aires, Patricias Argentinas, 435 (1405), Buenos Aires, Argentina. melola@leloir.org.ar
authors.forename: María T
authors.initials: MT
authors.lastname: Elola
authors.forename: María E
authors.initials: ME
authors.lastname: Chiesa
authors.forename: Alejandra Fernández
authors.initials: AF
authors.lastname: Alberti
authors.forename: José
authors.initials: J
authors.lastname: Mordoh
authors.forename: Nilda E
authors.initials: NE
authors.lastname: Fink
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D005677:G(M1) Ganglioside / Q000378:metabolism; D037483:Galectin 1 / Q000378:metabolism*; D006801:Humans; D011956:Receptors, Cell Surface / Q000378:metabolism*
chemical_list: D015703:Antigens, CD; D037483:Galectin 1; D011956:Receptors, Cell Surface; D005677:G(M1) Ganglioside