Anorectic and behavioural effects of chronic Cissampelos sympodialis treatment in female and male rats.
Male and female rats were treated daily for 13 weeks with an ethanol extract of Cissampelos sympodialis leaves (9, 45 and 225 mg[sol ]kg). The food consumption, body weight and behavioural effects in the open-field test were evaluated by weekly monitoring. The results showed that the extract chronic treatment in female rats (45 and 225 mg[sol ]kg) reduced significantly the food intake and the body weight, and produced several alterations in the open-field test. These findings indicate that repeated oral administration of the extract may produce a sex-dependent difference in anoretic and behavioural effects.
Almeida
R N
RN
Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba. Caixa Postal, João Pessoa, PB, Brazil. reinaldo@itf.ufpb.br
Melo-Diniz
M F F
MF
Medeiros
I A
IA
Quintans-Júnior
L J
LJ
Navarro
D S
DS
Falcão
A C G M
AC
Duarte
J C
JC
Barbosa-Filho
J M
JM
D000284:Administration, Oral; D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects; D031606:Cissampelos; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004435:Eating / Q000187:drug effects; D005260:Female; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar
D000928:Antidepressive Agents; D010936:Plant Extracts