Identification of a novel HLA-DQB1 allele, DQB1*0314, by sequence-based typing in the Korean population.
The polymorphism of HLA class II genes is largely confined to the exon 2 region. Sequence analysis of exon 2 of the DQB1 gene revealed the novel polymorphism in the Korean population. The new DQB1 allele, DQB1*0314, was differed from DQB1*0304 only at codon 46 (GAG-->GGG), corresponding to non-synonymous amino acid change (Glu-->Gly).
Gu
H
H
National Genome Research Institute, National Institute of Health, 5 Nokbun-Dong, Eunpyung-Gu, Seoul 122-701, Korea.
Kimm
K
K
Lee
J-K
JK
Oh
B
B
D000483:Alleles; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D003062:Codon / Q000235:genetics; D005091:Exons / Q000235:genetics; D005802:Genes, MHC Class II; D006683:HLA-DQ Antigens / Q000737:chemistry / Q000235:genetics* / Q000302:isolation & purification; D059866:HLA-DQ beta-Chains; D006801:Humans; D007723:Korea; D008562:Membrane Glycoproteins; D008969:Molecular Sequence Data; D017354:Point Mutation; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D003062:Codon; D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D008562:Membrane Glycoproteins