Angiocentric immunoproliferative lesion and angiocentric lymphoma of lymph node in children. A report of two cases.
OBJECTIVE
To report two examples of an angiocentric immunoproliferative lesion (AIL) and angiocentric angiodestructive lymphoma (AL) presenting in lymph nodes in children. Most commonly involving extranodal sites, AIL/AL rarely presents in the spleen and lymph nodes.


RESULTS
Case 1 presented as a cervical lymphadenopathy in a 3 year old girl being treated for pre-B cell acute lymphoblastic leukaemia. Histological and immunohistochemistry studies revealed an Epstein-Barr virus positive (EBV+), large B cell (CD20 and CD30+) AIL with large areas of necrosis, the whole resembling lymphomatoid granulomatosis. Case 2 presented as a large supraclavicular lymphadenopathy in a 13 year old boy. Histology and immunohistochemistry revealed an EBV-, large T cell (CD45RO, CD56, and CD30+) AL, presenting the features of so called angiocentric T cell/natural killer cell lymphoma, nasal type.


CONCLUSIONS
The term AIL/AL refers to a heterogeneous group of conditions not unique to a particular type of lymphoid cell. These lesions are easily recognised by the histopathologist because of their extremely unusual angiocentric pattern. Although rare, AIL/AL may present as nodal lesions in children ab initio.
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Department of Pathology, Hospital de Niños Superiora Sor María Ludovica, 1900, La Plata, Argentina. patologi@netverk.com.ar
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D000293:Adolescent; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007160:Immunoproliferative Disorders / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology*; D008206:Lymphatic Diseases / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000473:pathology*; D008230:Lymphomatoid Granulomatosis / Q000473:pathology; D008297:Male