title: Chondrosarcoma, lupus anticoagulant and cerebral ischaemia.
abstract: Chondrosarcoma is a malignant disease of cartilage. Systemic embolisation usually arises from cancerous invasion of pulmonary vessels or the left atrium but cerebral embolisation or ischaemia is rarely recognised. We report a man with left leg amputation for tibial myxoid chondrosarcoma who suffered multiple cerebral embolisms one year later. Cerebral angiography and aortogram did not reveal luminal stenosis and a cardiac survey was normal. Lupus anticoagulant (LAC) and a prolonged activated partial thromboplastin time were detected. A molecular mimicry between prothrombin and paracrine hormones may have accounted for his LAC. A procoagulant autoantibody reacting against metastatic cancer cells may contribute to cancerous thrombosis, such as in chondrosarcoma.
authors.affiliation: Stroke Biology Research Laboratory, Department of Neurology, Chang Gung Memorial Hospital, Niao Sung Hsiang, Kaohsiung, Taiwan.
authors.forename: Wei Hsi
authors.initials: WH
authors.lastname: Chen
authors.forename: Jia Shou
authors.initials: JS
authors.lastname: Liu
mesh_terms: D000671:Amputation, Surgical; D001859:Bone Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D002545:Brain Ischemia / Q000209:etiology / Q000473:pathology*; D002533:Cerebral Angiography; D002813:Chondrosarcoma / Q000150:complications / Q000473:pathology* / Q000601:surgery; D006801:Humans; D020766:Intracranial Embolism / Q000209:etiology; D007866:Leg / Q000601:surgery; D016682:Lupus Coagulation Inhibitor / Q000097:blood*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D013977:Tibia
chemical_list: D016682:Lupus Coagulation Inhibitor