title: Simultaneous onset of pemphigus vulgaris in two Turkish siblings.
abstract: The etiology of pemphigus vulgaris is still unknown. Reported familial cases are indicators of a genetic aspect of the disease. We report a brother and sister with simultaneous onset of pemphigus vulgaris. The class II antigens, HLA DRB1*04 and DQB1*03 were detected in both patients. The oral mucosa was affected in one them. Elevation of transaminase levels due to azathioprine therapy was observed in these two cases.
authors.affiliation: Abant Izzet Baysal University, Duzce Medical School, Department of Dermatology, Duzce, Turkey.
authors.forename: Ayşe
authors.initials: A
authors.lastname: Kavak
authors.forename: Ilker
authors.initials: I
authors.lastname: Aydoğan
authors.forename: Sevim
authors.initials: S
authors.lastname: Gönen
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D009061:Mouth Mucosa / Q000473:pathology; D010392:Pemphigus / Q000175:diagnosis* / Q000235:genetics*; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D012720:Severity of Illness Index; D035781:Siblings; D014421:Turkey
chemical_list: D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains