Mass spectrometrical analysis of human serine racemase in foetal brain.
We analysed human serine racemase for the first time from human foetal brain by mass spectrometrical methods, MALDI MS and MS/MS. The detection of human serine racemase from a transient area of human foetal brain, the perireticular nucleus, that is suggested to be mainly involved in guidance of corticofugal and thalamocortical fibers, may be a clue for the important role of this enzyme in neuronal migration and brain development via regulation of NMDA receptor activity.
Hepner
F
F
Department of Pediatrics, Medical University of Vienna, Austria.
Pollak
A
A
Ulfig
N
N
Yae-Kyung
M
M
Lubec
G
G
D000595:Amino Acid Sequence; D001921:Brain / Q000196:embryology* / Q000201:enzymology*; D001923:Brain Chemistry / Q000502:physiology*; D015180:Electrophoresis, Gel, Two-Dimensional; D005333:Fetus; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D019998:Racemases and Epimerases / Q000032:analysis* / Q000235:genetics / Q000378:metabolism; D000099300:Serine Racemase
D019998:Racemases and Epimerases; D000099300:Serine Racemase