Cross-cultural evaluation of health status using item response theory: FACT-B comparisons between Austrian and U.S. patients with breast cancer.
To make meaningful cross-cultural comparisons of health-related quality of life (HRQOL) or to pool international research data, it is essential to create culturally unbiased measures that detect clinically important differences between patients. We evaluated the measurement properties of the Functional Assessment of Cancer Therapy-Breast (FACT-B) in 111 Austrian and 144 U.S. patients with breast cancer using item response theory (IRT) methods. A small number of items were identified as displaying statistically significant differential item functioning (DIF), suggesting possible measurement bias. The majority of the items functioned similarly between the two cultural groups. U.S. patients reported lower (worse) physical function and well-being compared with Austrian patients, higher (better) social/family well-being and similar emotional well-being, before and after adjustment for DIF. IRT and related measurement models provide useful methods for assessing cross-cultural equivalence and determining which items can be pooled across languages before analyzing HRQOL data. Determination of clinically significant cross-cultural differences will require additional investigation.
Hahn
Elizabeth A
EA
Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Evanston, IL 60201, USA. e-hahn@northwestern.edu
Holzner
Bernhard
B
Kemmler
Georg
G
Sperner-Unterweger
Barbara
B
Hudgens
Stacie A
SA
Cella
David
D
D001317:Austria / Q000453:epidemiology; D001943:Breast Neoplasms / Q000453:epidemiology / Q000523:psychology*; D003431:Cross-Cultural Comparison; D003627:Data Interpretation, Statistical; D005260:Female; D006304:Health Status; D006801:Humans; D011594:Psychometrics; D011788:Quality of Life; D011795:Surveys and Questionnaires; D014481:United States / Q000453:epidemiology