title: Cognitive function and cerebral assessment in patients who have Cushing's syndrome.
abstract: Cushing's syndrome (CS) is a relevant model to better understand the effects of glucocorticoid (GC) excess on the human brain. The importance of GC excess on the central nervous system is highlighted by the high prevalence of neuropsychiatric disorders such as depression and cognitive impairment in patients who have CS. In addition, there is a high incidence of apparent diffuse loss of brain volume in patients who have CS. Recent studies indicate at least partial reversibility of these abnormalities following correction of hypercortisolism.
authors.affiliation: Division of Endocrinology, Department of Medicine, Hôtel-Dieu du Centre Hospitalier de l'Université de Montréal, 3840 Saint-Urbain Street, Montreal, Quebec H2W 1T8, Canada. isabelle.bourdeau@umontreal.ca
authors.forename: Isabelle
authors.initials: I
authors.lastname: Bourdeau
authors.forename: Céline
authors.initials: C
authors.lastname: Bard
authors.forename: Hélène
authors.initials: H
authors.lastname: Forget
authors.forename: Yvan
authors.initials: Y
authors.lastname: Boulanger
authors.forename: Henri
authors.initials: H
authors.lastname: Cohen
authors.forename: André
authors.initials: A
authors.lastname: Lacroix
mesh_terms: D003071:Cognition; D003072:Cognition Disorders / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology; D003480:Cushing Syndrome / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging