title: Enzymatic resolution of (+/-)-5-acetoxy-4-aryl-(2E)-pentenoate derivatives.
abstract: Enzymatic resolution of six (+/-)-5-acetoxy-4-aryl-(2E)-pentenoate derivatives, compounds 9, 11, 13, 15, 17, and 19 bearing a different aromatic substitution pattern, using lipase OF-360 from Candida rugosa was carried out. The absolute configurations of all hydrolyzed products and all unchanged acetates were found to be S and R, respectively. Moreover, the enantiomeric excess of the enzymatic resolution products from 9, 11, and 13 with the ortho-methoxyl group in the aromatic ring was higher than that of the substrates with no methoxyl group at the ortho-position in the aromatic ring.
authors.affiliation: School of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Chiba 274-8510, Japan.
authors.forename: Shin
authors.initials: S
authors.lastname: Tanikawa
authors.forename: Machiko
authors.initials: M
authors.lastname: Ono
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Akita
mesh_terms: D000475:Alkenes / Q000032:analysis / Q000737:chemistry*; D008049:Lipase / Q000032:analysis / Q000737:chemistry*; D010422:Pentanones / Q000032:analysis / Q000737:chemistry*
chemical_list: D000475:Alkenes; D010422:Pentanones; D008049:Lipase