Direct catalytic synthesis of enantiopure 5-substituted oxazolidinones from racemic terminal epoxides.
A venerable scaffold for asymmetric synthesis and drug development, chiral 5-substituted oxazolidinones are obtained in almost enantiomerically pure form (up to 99.9% ee) starting from racemic terminal epoxides. The salient features of this process include the very simple and convenient experimental protocol and the employment of a readily accessible catalyst and inexpensive, easily handled starting materials. An enantioconvergent approach for the total conversion of racemic epoxide into a single stereoisomeric oxazolidinone is also described.
Bartoli
Giuseppe
G
Department of Organic Chemistry A. Mangini, University of Bologna, Italy. giuseppe.bartoli@unibo.it
Bosco
Marcella
M
Carlone
Armando
A
Locatelli
Manuela
M
Melchiorre
Paolo
P
Sambri
Letizia
L