title: [Comparative genomic hybridization: the profile of chromosomal imbalances in esophageal squamous cell carcinoma].
abstract: OBJECTIVE
  To characterize the profile of chromosomal imbalances of esophageal squamous cell carcinoma (SCC) in Linzhou, the high prevalence area of Henan province.
  
  
  METHODS
  Comparative genomic hybridization (CGH) was used to examine 52 cases of primary SCC of esophagus.
  
  
  RESULTS
  Gains in part or in whole of chromosome 3q, 8q, 5p, 1q, 6q, 18p, 20q and losses of 3p, 1p, 9q, 19p, 4p, 8p were detected frequently in SCC (> 20%). Gain of 3q, 5p, 1q, 11q13-14 and loss of 4pq, 13q were all significantly correlated with pathologic staging (P < 0.05). Gains of 8q, loss of 4p were linked to nodal metastasis (P < 0.05). Gains of 2p and loss of 4pq, 11q14-qter were associated with distant organ metastasis (P < 0.05).
  
  
  CONCLUSIONS
  These observations suggest that 3q, 8q, 5p, 1q, 6q, 18p, and 20q may contain SCC-related oncogenes; 3p, 1p, 9q, 19p, 4p and 8p may contain SCC-related tumor suppressor genes. It is likely that gain of 3q, 5p, 1q, 11q13-14 and loss of 4pq, 13q are the genetic aberrations critical for the development of esophageal carcinoma, whereas gains of 8q, 2p and loss of 4pq, 11q14-qter are considered later events associated with tumor progression and are thought to confer metastatic potential to esophageal carcinoma. Furthermore, nodal and distant organ metastases involve different genes.
authors.affiliation: Laboratory for Cancer Research, College of Medicine, Zhengzhou University, Zhengzhou 450052, China. lidong0823@sina.com
authors.forename: Yan-Ru
authors.initials: YR
authors.lastname: Qin
authors.forename: Li-Dong
authors.initials: LD
authors.lastname: Wang
authors.forename: Dora
authors.initials: D
authors.lastname: Kwong
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Gao
authors.forename: Xin-Yuan
authors.initials: XY
authors.lastname: Guan
authors.forename: Ze-Hao
authors.initials: ZH
authors.lastname: Zhuang
authors.forename: Zong-Min
authors.initials: ZM
authors.lastname: Fan
authors.forename: Wen
authors.initials: W
authors.lastname: Deng
authors.forename: Liang
authors.initials: L
authors.lastname: Hu
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002893:Chromosomes, Human, Pair 3; D002894:Chromosomes, Human, Pair 4; D002898:Chromosomes, Human, Pair 8; D004938:Esophageal Neoplasms / Q000235:genetics*; D005784:Gene Amplification; D006801:Humans; D008207:Lymphatic Metastasis; D009362:Neoplasm Metastasis / Q000235:genetics; D009367:Neoplasm Staging; D009693:Nucleic Acid Hybridization