title: Synthesis of phthalates of betulinic acid and betulin with cytotoxic activity.
abstract: Synthesis of 3beta-O-phthalic esters from betulinic acid and its esters and synthesis of phthalic esters from betulin and its monoacetates using classical acylation procedure with phthalic anhydride. The evaluation of cytotoxicity of the prepared compounds was using numbers of tumor cell lines in MTT test. It was discovered that hemiphthalic esters had better cytotoxicity than starting compounds as betulinic acid or quite inactive betulin.
authors.affiliation: Department of Organic and Nuclear Chemistry, Faculty of Science, Charles University in Prague, Hlavova 8, 128 43 Prague 2, Czech Republic.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Kvasnica
authors.forename: Jan
authors.initials: J
authors.lastname: Sarek
authors.forename: Eva
authors.initials: E
authors.lastname: Klinotova
authors.forename: Petr
authors.initials: P
authors.lastname: Dzubak
authors.forename: Marian
authors.initials: M
authors.lastname: Hajduch
mesh_terms: D000215:Acylation; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D004952:Esters / Q000737:chemistry; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D053978:Pentacyclic Triterpenes; D010795:Phthalic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D014315:Triterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D000094062:Betulinic Acid
chemical_list: D000970:Antineoplastic Agents; D004952:Esters; D053978:Pentacyclic Triterpenes; D010795:Phthalic Acids; D014315:Triterpenes; C002503:betulin; D000094062:Betulinic Acid