Hypothalamic sensing of fatty acids.
Selective regions of the brain, including the hypothalamus, are capable of gathering information on the body's nutritional status in order to implement appropriate behavioral and metabolic responses to changes in fuel availability. This review focuses on direct metabolic signaling within the hypothalamus. There is growing evidence supporting the idea that fatty acid metabolism within discrete hypothalamic regions can function as a sensor for nutrient availability that can integrate multiple nutritional and hormonal signals.
Lam
Tony K T
TK
Department of Medicine and Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Schwartz
Gary J
GJ
Rossetti
Luciano
L
D000214:Acyl Coenzyme A / Q000378:metabolism; D000818:Animals; D001069:Appetite Regulation / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D005227:Fatty Acids / Q000378:metabolism*; D025461:Feedback, Physiological / Q000502:physiology*; D006801:Humans; D007031:Hypothalamus / Q000502:physiology*; D007333:Insulin Resistance / Q000502:physiology; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology; D015398:Signal Transduction / Q000502:physiology
D000214:Acyl Coenzyme A; D005227:Fatty Acids