title: [Effects of long-term exposure of low level zinc and zn-EDTA complex on zinc accumulation and antioxidant defense system in liver of Carassius auratus].
abstract: The effects of low level zinc(Zn2+)and its EDTA complex on zinc accumulation and antioxidant enzymes,such as catalase (CAT), superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione peroxidase (GPx) in the liver of Carassius auratus are studied after 40 day exposure. The results show that zinc accumulation is significantly increased with higher zinc concentration. When fish are exposed to Zn-EDTA, the zinc accumulation in the liver of fish increased slightly according to the control. SOD, GST, CAT and GPx activity all decrease with adding to Zn2+ and Zn-EDTA in waters. However, the decrease of CAT and GPx activities of fish liver are alleviated with the addition of EDTA. The GST activities increased at lower concentration solutions ( < 0.05mg-L(-1) ), however its activities were inhibited at higher Zn2 + solution ( > 0.05mgL- ). These results suggest that CAT and GPx are more sensitive to low zinc exposure than SOD and GST, and they can be served as biomarkers of low concentration zinc exposure in aquatic ecosystem.
authors.affiliation: State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing 210093, China. liuhui97@sohu.com
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.forename: Xiao-rong
authors.initials: XR
authors.lastname: Wang
authors.forename: Wei-mu
authors.initials: WM
authors.lastname: Wang
authors.forename: Hua
authors.initials: H
authors.lastname: Shen
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D004492:Edetic Acid / Q000009:adverse effects / Q000737:chemistry; D004784:Environmental Monitoring / Q000379:methods; D005979:Glutathione Peroxidase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006054:Goldfish / Q000378:metabolism*; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000009:adverse effects*; D015032:Zinc / Q000009:adverse effects* / Q000737:chemistry
chemical_list: D000975:Antioxidants; D014874:Water Pollutants, Chemical; D004492:Edetic Acid; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; D015032:Zinc