Comparison of in vitro activities of antifungal drugs and ethanolic extract of propolis against Trichophyton rubrum and T. mentagrophytes by using a microdilution assay.
The in vitro activities of propolis against 29 strains of dermatophytes were compared with those of terbinafine, itraconazole, ketoconazole, and fluconazole. Minimal inhibitory concentrations (MICs) were determined according to a National Committee for Clinical Laboratory Standards broth microdilution method. Among the systemic antifungals tested, terbinafine was the most potent. Propolis showed important antifungal activity and it merits further investigation as a potentially useful agent for the treatment of dermatophytosis.
Koc
A N
AN
Medical Faculty, Department of Microbiology, Erciyes University, Kayseri, Turkey.
Silici
S
S
Ayangil
D
D
Ferahbaş
A
A
Cankaya
S
S
D000935:Antifungal Agents / Q000494:pharmacology*; D015725:Fluconazole / Q000494:pharmacology; D017964:Itraconazole / Q000494:pharmacology; D007654:Ketoconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000494:pharmacology; D011429:Propolis / Q000737:chemistry / Q000494:pharmacology*; D000077291:Terbinafine; D014249:Trichophyton / Q000187:drug effects*; D014421:Turkey
D000935:Antifungal Agents; D009281:Naphthalenes; D017964:Itraconazole; D015725:Fluconazole; D011429:Propolis; D000077291:Terbinafine; D007654:Ketoconazole