[Expression of cylooxygenase-2 in endometriosis].
OBJECTIVE
To investigate the expression of cyclooxygense-2 (COX-2) in eutopic and ectopic endometrium in ovarian endometriosis.


METHODS
Thirty patients with ovrian endometriosis, 10 with ovarian chocolate cysts and 27 normal controls were enrolled it determine the expression of COX-2 immunohistochemically in eutopic or ectopic endometrium or healthy endometrial tissues.


RESULTS
The immunoreactivities of COX-2 were found in epithelial cells and stromal cells in eutopic endometrium. The expression of COX-2 in the epithelial cells in the secretory phase was higher than that in the proliferative phase in the control group and ovarian endometriosis group (P <0. 05). But the expression of COX-2 in stromal cells in the control group and ovarian endometriosis group showed no cyclic changes throughout the menstrual cycle (P > 0. 05). The expression of COX-2 in eutopic and ectopic endometrium in the ovarian endometriosis group was higher than that in the control group (P <0. 05) , hut we did not find significant difference between the eutopic and ectopic endometrium in the ovarian endometriosis group (P > 0. 05).


CONCLUSIONS
The increased COX-2 expression in eutopic and ectopic endometrium in ovarian endometriosis may he related to its pathology.
Fan
Hong
H
Department of Gynecology and Obstetrics, Second Xiangya Hospital, Central South University, Changsha, China. fanwentao2002@yahoo.com.cn
Fang
Xiao-ling
XL
D000328:Adult; D051546:Cyclooxygenase 2 / Q000096:biosynthesis* / Q000235:genetics; D004715:Endometriosis / Q000201:enzymology*; D004717:Endometrium / Q000201:enzymology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010049:Ovarian Diseases / Q000201:enzymology*
D051546:Cyclooxygenase 2