Estrogen-related receptor expression in placenta throughout gestation.
Estrogen receptor (ER) alpha and beta mRNA levels increased from the first to the second trimester and then decreased until normal term delivery. Estrogen-related receptor (ERR) alpha, beta and gamma mRNA levels gradually increased up to the second trimester and then comparatively rapidly increased until normal term delivery. ERRs can bind to the steroid receptor coactivator family without any ligands and drive transcription activity of the target genes. The manner of ERR and ER gene expressions might show a competitive interaction associated with the use of common cofactors. It is speculated that the up-regulation of ERRs is related to placental growth after the down-regulation of ERs because of the remarkably high concentration of estrogens for ERs from the second trimester until delivery.
Fujimoto
Jiro
J
Department of Obstetrics and Gynecology, Gifu University School of Medicine, 1-1 Yanagido, Gifu City 501-1194, Japan. jf@cc.gifu-u.ac.jp
Nakagawa
Yumiko
Y
Toyoki
Hiroshi
H
Sakaguchi
Hideki
H
Sato
Eriko
E
Tamaya
Teruhiko
T
D001483:Base Sequence; D017931:DNA Primers; D047628:Estrogen Receptor alpha / Q000235:genetics*; D047629:Estrogen Receptor beta / Q000235:genetics*; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D005865:Gestational Age; D006801:Humans; D010920:Placenta / Q000502:physiology*; D011247:Pregnancy; D011960:Receptors, Estrogen / Q000235:genetics*
D017931:DNA Primers; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D011960:Receptors, Estrogen; C425824:estrogen receptor gamma