[New dimeric phthalide derivative from Angelica sinensis].
OBJECTIVE
To study the chemical constituents of the roots of Angelica sinensis.


METHODS
Silica gel column chromatography was used to separate the chemical constituents. Their structures were elucidated by chemical and spectral analysis (IR, MS, 1D and 2D NMR, etc.).


RESULTS
Besides three known phthalide derivatives, one new dimeric phthalide derivative and a pair of epimer were isolated and their structures were identified as Z-3',8',3'a,7'a-tetrahydro-6,3',7,7'a-diligustilide-8'-one (1), Z,Z'-6,6',7,3'a-diligustilide (2) and the 8-epimer (3) of 2 on the basis of spectral data.


CONCLUSIONS
Compound 1 is a new dimeric phthalide derivative, and compound 3 was first reported from radix Angelica
Su
Dong-min
DM
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Yu
Shi-shan
SS
Qin
Hai-lin
HL
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D029971:Angelica sinensis / Q000737:chemistry*; D001572:Benzofurans; D008968:Molecular Conformation; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism
D001572:Benzofurans; C509377:Z-3',8',3'a,7'a-tetrahydro-6,3',7,7'a-diligustilide-8'-one; C523615:levistolide A; D015107:4-Butyrolactone