Preparation of carboxymethyl chitosan in aqueous solution under microwave irradiation.
Carboxymethyl chitosan was prepared by reacting chitosan with chloroacetic acid in water under microwave irradiation. The effect of the reaction conditions was investigated and optimal conditions were identified. The influence of mass ratio of chloroacetic acid to chitosan, microwave power and pH on the degree of substitution or intrinsic viscosity were further studied. The degree of substitution of the carboxymethyl chitosan synthesized exceeded 0.85.
Ge
Hua-Cai
HC
College of Chemistry, South China University of Technology, Guangzhou 510640, China. chhcge@scut.edu.cn
Luo
Deng-Ke
DK
D000085:Acetates / Q000737:chemistry; D048271:Chitosan / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000528:radiation effects; D006863:Hydrogen-Ion Concentration; D008872:Microwaves; D012996:Solutions; D017550:Spectroscopy, Fourier Transform Infrared; D014867:Water / Q000737:chemistry
D000085:Acetates; C504164:O-carboxymethylchitosan; D012996:Solutions; D014867:Water; C006972:chloroacetic acid; D048271:Chitosan