title: Pulmonary haemodynamics at rest and during exercise in patients with significant pulmonary vein stenosis after radiofrequency catheter ablation for drug resistant atrial fibrillation.
abstract: OBJECTIVE
  Iatrogenic pulmonary vein (PV) stenosis after radiofrequency catheter ablation for atrial fibrillation (AF) is a new pathology in cardiology. The effects of PV stenosis on the pulmonary circulation are not yet known. We provide long-term follow-up data in patients with significant PV stenosis including magnetic resonance imaging (MRI) and Swan Ganz (SG) right heart catheterization.
  
  
  RESULTS
  One hundred and seventeen patients had MRI 12-24 months after the AF ablation procedure. Eleven patients (58+/-7 years, nine males) with significant stenosis (n=9) or occlusion of the proximal PV (n=5) at this follow-up were re-examined using MRI and SG right heart catheterization at rest and during exercise (follow-up time since PV ablation 50+/-15 months). None of these underwent previous PV angioplasty. When compared with prior MRI studies, no significant changes were noted. At rest, no patient had pulmonary hypertension. At 100 W, seven patients had elevated pulmonary artery pressures, three of them probably caused, in part, by left ventricular dysfunction.
  
  
  CONCLUSIONS
  Significant stenosis/occlusions of one or two PV do not create pulmonary hypertension at rest during long-term follow-up. However, seven of the 11 patients develop pulmonary hypertension during exercise. All three patients with stenosis/occlusions of two PV were affected.
authors.affiliation: Abteilung Rhythmologie, Herz-Zentrum, Südring 15, 79188 Bad Krozingen, Germany. thomas.arentz@herzzentrum.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Arentz
authors.forename: Reinhold
authors.initials: R
authors.lastname: Weber
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Jander
authors.forename: Gerd
authors.initials: G
authors.lastname: Bürkle
authors.forename: Jörg
authors.initials: J
authors.lastname: von Rosenthal
authors.forename: Thomas
authors.initials: T
authors.lastname: Blum
authors.forename: Jochem
authors.initials: J
authors.lastname: Stockinger
authors.forename: Laurent
authors.initials: L
authors.lastname: Haegeli
authors.forename: Franz Josef
authors.initials: FJ
authors.lastname: Neumann
authors.forename: Dietrich
authors.initials: D
authors.lastname: Kalusche
mesh_terms: D001281:Atrial Fibrillation / Q000503:physiopathology / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods*; D003251:Constriction, Pathologic / Q000209:etiology; D004351:Drug Resistance; D015444:Exercise / Q000502:physiology*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011667:Pulmonary Veins; D014057:Tomography, X-Ray Computed