Structure-based design of protein tyrosine phosphatase-1B inhibitors.
Using structure-based design, a new class of inhibitors of protein tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the 1,2,5-thiadiazolidin-3-one-1,1-dioxide template.
Black
Emma
E
AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK.
Breed
Jason
J
Breeze
Alexander L
AL
Embrey
Kevin
K
Garcia
Robert
R
Gero
Thomas W
TW
Godfrey
Linda
L
Kenny
Peter W
PW
Morley
Andrew D
AD
Minshull
Claire A
CA
Pannifer
Andrew D
AD
Read
Jon
J
Rees
Amanda
A
Russell
Daniel J
DJ
Toader
Dorin
D
Tucker
Julie
J
D018360:Crystallography, X-Ray; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013829:Thiadiazines / Q000737:chemistry* / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D008024:Ligands; D013829:Thiadiazines; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases