title: Clinical efficacy of apple polyphenol for treating cedar pollinosis.
abstract: A double-blind comparative study was conducted on cedar pollinosis patients in order to evaluate the treatment efficacy of apple polyphenol (Ap). Ap was administered (500 mg) once daily for 12 weeks, starting about 2 weeks prior to cedar pollen dispersion. Pollinosis symptoms during the study were evaluated according to the classification in the guidelines for allergic rhinitis diagnosis and treatment. The results show that the sneezing score was significantly lower for the Ap group than with the placebo group during the early period of pollen dispersion and during the main dispersion period. In addition, no adverse reactions were induced by Ap during the study. These results suggest that Ap may alleviate the symptoms of cedar pollinosis.
authors.affiliation: Otsu Nutraceutical Research Institute, Otsuka Pharmaceutical Co., Ltd., Shiga 520-0002, Japan. k_kishi@research.otsuka.co.jp
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Kishi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Saito
authors.forename: Takao
authors.initials: T
authors.lastname: Saito
authors.forename: Megumi
authors.initials: M
authors.lastname: Kumemura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Okamatsu
authors.forename: Misa
authors.initials: M
authors.lastname: Okita
authors.forename: Kenji
authors.initials: K
authors.lastname: Takazawa
mesh_terms: D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D028203:Cedrus / Q000276:immunology*; D004311:Double-Blind Method; D005419:Flavonoids / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007564:Japan; D027845:Malus / Q000737:chemistry*; D010636:Phenols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011058:Pollen / Q000276:immunology*; D059808:Polyphenols; D012221:Rhinitis, Allergic, Perennial / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D012912:Sneezing; D013997:Time Factors
chemical_list: D018926:Anti-Allergic Agents; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols