title: Effects of air pollutants on childhood asthma.
abstract: Epidemiologic studies have suggested the association between environmental exposure to volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs) and the increased risk of incurring asthma. Yet there is little data regarding the relationship between personal exposure to air pollution and the incidence of asthma in children. This study was designed to evaluate the effect of exposure to air pollution on children with asthma by using exposure biomarkers. We assessed the exposure level to VOCs by measuring urinary concentrations of hippuric acid and muconic acid, and PAHs by 1-OH pyrene and 2-naphthol in 30 children with asthma and 30 children without asthma (control). The mean level of hippuric acid was 0.158 +/- 0.169 micromol/mol creatinine in the asthma group and 0.148 +/- 0.249 micromol/mol creatinine in the control group, with no statistical significance noted (p=0.30). The mean concentration of muconic acid was higher in the asthma group than in the control group (7.630 +/- 8.915 micromol/mol creatinine vs. 3.390 +/- 4.526 micromol/mol creatinine p=0.01). The mean level of urinary 1-OHP was higher in the asthma group (0.430 +/- 0.343 micromol/mol creatinine) than the control group (0.239 +/- 0.175 micromol/mol creatinine), which was statistically significant (p=0.03). There was no difference in the mean concentration of 2-NAP between the two groups (9.864 +/- 10.037 micromol/mol in the asthma group vs. 9.157 +/- 9.640 micromol/mol in the control group, p=0.96). In conclusion, this study suggests that VOCs and PAHs have some role in asthma.
authors.affiliation: Department of Pediatrics, Inha University College of Medicine, 7-206 3-ga, Shinheung-dong, Jung-gu, Incheon, Korea.
authors.forename: Jeong-Hee
authors.initials: JH
authors.lastname: Kim
authors.forename: Ja-Kyoung
authors.initials: JK
authors.lastname: Kim
authors.forename: Byong-Kwan
authors.initials: BK
authors.lastname: Son
authors.forename: Ji-Eun
authors.initials: JE
authors.lastname: Oh
authors.forename: Dae-Hyun
authors.initials: DH
authors.lastname: Lim
authors.forename: Kwan-Hee
authors.initials: KH
authors.lastname: Lee
authors.forename: Youn-Chol
authors.initials: YC
authors.lastname: Hong
authors.forename: Sung-Il
authors.initials: SI
authors.lastname: Cho
mesh_terms: D000393:Air Pollutants / Q000494:pharmacology*; D001249:Asthma / Q000503:physiopathology* / Q000652:urine; D016022:Case-Control Studies; D002675:Child, Preschool; D003404:Creatinine / Q000652:urine; D005260:Female; D006626:Hippurates / Q000652:urine; D006801:Humans; D008297:Male; D009284:Naphthols / Q000652:urine; D009930:Organic Chemicals / Q000737:chemistry / Q000494:pharmacology*; D011084:Polycyclic Aromatic Hydrocarbons / Q000494:pharmacology*; D011721:Pyrenes / Q000378:metabolism; D013011:Sorbic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D014835:Volatilization
chemical_list: D000393:Air Pollutants; D006626:Hippurates; D009284:Naphthols; D009930:Organic Chemicals; D011084:Polycyclic Aromatic Hydrocarbons; D011721:Pyrenes; C005939:muconic acid; D003404:Creatinine; C033146:1-hydroxypyrene; C028405:2-naphthol; C030514:hippuric acid; D013011:Sorbic Acid