Fexofenadine pharmacokinetics are associated with a polymorphism of the SLCO1B1 gene (encoding OATP1B1).
Niemi
Mikko
M
Kivistö
Kari T
KT
Hofmann
Ute
U
Schwab
Matthias
M
Eichelbaum
Michel
M
Fromm
Martin F
MF
D019540:Area Under Curve; D006579:Heterozygote; D006634:Histamine H1 Antagonists / Q000493:pharmacokinetics*; D006801:Humans; D027381:Liver-Specific Organic Anion Transporter 1; D027362:Organic Anion Transport Protein 1 / Q000235:genetics*; D027361:Organic Anion Transporters / Q000235:genetics; D029362:Organic Anion Transporters, Sodium-Independent / Q000235:genetics*; D011110:Polymorphism, Genetic; D016593:Terfenadine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
D006634:Histamine H1 Antagonists; D027381:Liver-Specific Organic Anion Transporter 1; D027362:Organic Anion Transport Protein 1; D027361:Organic Anion Transporters; D029362:Organic Anion Transporters, Sodium-Independent; C503999:SLCO1B1 protein, human; D016593:Terfenadine; C093230:fexofenadine