[Alternative to donor organs--the method of cultivation from fragments of tissues of "new organs" in an organism of the recipient].
A method of "new liver" growing inside of the recipients' organism as an alternative of the donor organs is presented. Experiments were carried out on the 90 Wistar rats. Animals were divided into 3 equal groups. All of the animals were subjected to 40% hepatectomy. The liver fragments were harvested from resected lobe. The animals of the I group received liver fragments transplantation into the greater omentum pocket, animals of the II group--into the peritoneal cavity and animals of the III group--into the "Kakabadze Biocontainer". All animals were under the standard vivarium conditions and were sacrificed in the different time points. The maximal follow up period was 6 months. Performed investigations have shown that vascularized, denuded segment of small intestine is uncial site for the engraftment and future development of transplanted liver fragments.
Mestiashvili
M Z
MZ
Department of Clinical Laboratory Diagnostics and Department of Clinical Anatomy, State Medical Academy, Tbilisi, Georgia.
Berishvili
E R
ER
Bukia
T Sh
TSh
D000825:Animal Structures / Q000254:growth & development*; D000818:Animals; D022781:Hepatocytes / Q000166:cytology; D008099:Liver / Q000166:cytology* / Q000254:growth & development* / Q000502:physiology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000502:physiology; D014019:Tissue Donors; D020858:Tissue and Organ Harvesting