Early regression in social communication in autism spectrum disorders: a CPEA Study.
In a multisite study of 351 children with autism spectrum disorders, 21 children with developmental delays, and 31 children with typical development, this study used caregiver interviews (i.e., the Autism Diagnostic Interview-Revised) at the time of entry into other research projects and follow-up telephone interviews designed for this project to describe the children's early acquisition and loss of social-communication milestones. Children who had used words spontaneously and meaningfully and then stopped talking were described by their caregivers as showing more gestures, greater participation in social games, and better receptive language before the loss and fewer of these skills after the loss than other children with autism spectrum disorders. A significant minority of children with autism without word loss showed a very similar pattern of loss of social-communication skills, a pattern not observed in the children with developmental delays or typical development.
Luyster
Rhiannon
R
Autism & Communication Disorders Center, University of Michigan, Ann Arbor 48109-2054, USA.
Richler
Jennifer
J
Risi
Susan
S
Hsu
Wan-Ling
WL
Dawson
Geraldine
G
Bernier
Raphael
R
Dunn
Michelle
M
Hepburn
Susan
S
Hyman
Susan L
SL
McMahon
William M
WM
Goudie-Nice
Julie
J
Minshew
Nancy
N
Rogers
Sally
S
Sigman
Marian
M
Spence
M Anne
MA
Goldberg
Wendy A
WA
Tager-Flusberg
Helen
H
Volkmar
Fred R
FR
Lord
Catherine
C
D000367:Age Factors; D001321:Autistic Disorder / Q000150:complications*; D002648:Child; D003147:Communication Disorders / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D012043:Regression, Psychology; D012720:Severity of Illness Index; D012919:Social Behavior