Pectenotoxin-2 synthetic studies. 2. Construction and conjoining of ABC and DE Eastern hemisphere subtargets.
[reaction: see text] Practical asymmetric synthesis of aldehyde 2 and tetrazolyl sulfone 3 has allowed for their coupling via Julia olefination to generate 32 as a single product. This substance possesses the entire carbon backbone of the A-E substructure of pectenotoxin-2.
Bondar
Dmitriy
D
Evans Chemical Laboratories, The Ohio State University, Columbus, Ohio 43210, USA.
Liu
Jian
J
Müller
Thomas
T
Paquette
Leo A
LA
D001688:Biological Products / Q000138:chemical synthesis*; D002384:Catalysis; D005663:Furans / Q000138:chemical synthesis*; D018942:Macrolides; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011714:Pyrans / Q000138:chemical synthesis*; D000095702:Polyether Toxins
D001688:Biological Products; D005663:Furans; D018942:Macrolides; D011714:Pyrans; C098380:pectenotoxin 2; D000095702:Polyether Toxins