title: Treatment of intra-abdominal bleeding with recombinant activated factor VII in a patient with disseminated intravascular coagulation secondary to septic shock.
abstract: Although mainly indicated for treatment of bleeding in haemophilia patients with inhibitors, recombinant activated factor VII (rFVIIa) has also been successfully used in other situations. However, no data are available on its use in the treatment of disseminated intravascular coagulation (DIC) secondary to septic shock. We report a man with DIC and septic shock due to retrocaecal appendicitis and severe intra-abdominal bleeding after surgery. Despite conventional treatment, the bleeding persisted, and treatment with rFVIIa controlled the haemorrhage. No side-effects related to rFVIIa were noted. This case suggests a potential role of rFVIIa in the treatment of severe bleeding associated with DIC.
authors.affiliation: Department of Haematology, Hospital Universitario La Fe, Av. Campanar 21, 46009 Valencia, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Martínez
authors.forename: Ana Rosa
authors.initials: AR
authors.lastname: Cid
authors.forename: Javier
authors.initials: J
authors.lastname: de la Rubia
authors.forename: Ricardo
authors.initials: R
authors.lastname: Gimeno
mesh_terms: D000005:Abdomen / Q000098:blood supply*; D001064:Appendicitis / Q000150:complications / Q000601:surgery; D004211:Disseminated Intravascular Coagulation / Q000150:complications* / Q000209:etiology; D005167:Factor VII / Q000627:therapeutic use*; D015942:Factor VIIa; D006470:Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011994:Recombinant Proteins / Q000627:therapeutic use; D012772:Shock, Septic / Q000150:complications*
chemical_list: D011994:Recombinant Proteins; D005167:Factor VII; C103587:recombinant FVIIa; D015942:Factor VIIa