title: High dose intermittent ARA-C (HiDAC) for consolidation of patients with de novo AML: a single center experience.
abstract: High dose intermittent ARA-C (2x3 g/m(2) i.v., days 1, 3, 5)=HiDAC was introduced as consolidation in AML by the CALGB-group in 1994. We treated 44 de novo AML patients in CR with up to four cycles of HiDAC (four cycles: 56.8%; three cycles: 22.7%; two cycles: 6.8%; one cycle: 13.7%). Median duration of aplasia (ANC<0.5x10(9)/l) was 12 days. Neutropenic fever occurred in 38.6% of the patients during the first, 52.6% during the second, 45.7% during the third, and in 40% during the fourth cycle. Non-hematologic toxicity was tolerable. The median overall- and disease-free survival were 19.3 and 11.3 months, respectively. The best outcome was seen in patients aged <40 years. These results confirm that HiDAC is a safe and effective consolidation in AML.
authors.affiliation: Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Böhm
authors.forename: Maria
authors.initials: M
authors.lastname: Piribauer
authors.forename: Friedrich
authors.initials: F
authors.lastname: Wimazal
authors.forename: Klaus
authors.initials: K
authors.lastname: Geissler
authors.forename: Heinz
authors.initials: H
authors.lastname: Gisslinger
authors.forename: Paul
authors.initials: P
authors.lastname: Knöbl
authors.forename: Ulrich
authors.initials: U
authors.lastname: Jäger
authors.forename: Christa
authors.initials: C
authors.lastname: Fonatsch
authors.forename: Paul A
authors.initials: PA
authors.lastname: Kyrle
authors.forename: Peter
authors.initials: P
authors.lastname: Valent
authors.forename: Klaus
authors.initials: K
authors.lastname: Lechner
authors.forename: Wolfgang R
authors.initials: WR
authors.lastname: Sperr
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003561:Cytarabine / Q000627:therapeutic use*; D003630:Daunorubicin / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005047:Etoposide / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D003561:Cytarabine; D005047:Etoposide; D003630:Daunorubicin