title: Spread of a Klebsiella pneumoniae strain producing a plasmid-mediated ACC-1 AmpC beta-lactamase in a teaching hospital admitting disabled patients.
abstract: We describe a large outbreak involving a Klebsiella pneumoniae strain producing a plasmid-encoded ACC-1 type AmpC beta-lactamase in a hospital caring for patients with motor impairment. The epidemic strain was isolated from 57 patients in six wards between September 1999 and May 2003 and caused clinical infections in 19 patients.
authors.affiliation: Laboratoire de microbiologie, Hôpital Raymond Poincaré, 104 Boulevard Raymond Poincaré, 92380 Garches, France.
authors.forename: Salomon
authors.initials: S
authors.lastname: Ohana
authors.forename: Veronique
authors.initials: V
authors.lastname: Leflon
authors.forename: Esthel
authors.initials: E
authors.lastname: Ronco
authors.forename: Martin
authors.initials: M
authors.lastname: Rottman
authors.forename: Didier
authors.initials: D
authors.lastname: Guillemot
authors.forename: Sylvie
authors.initials: S
authors.lastname: Lortat-Jacob
authors.forename: Pierre
authors.initials: P
authors.lastname: Denys
authors.forename: Georges
authors.initials: G
authors.lastname: Loubert
authors.forename: Marie-Helène
authors.initials: MH
authors.lastname: Nicolas-Chanoine
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Gaillard
authors.forename: Christine
authors.initials: C
authors.lastname: Lawrence
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics*; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology*; D017931:DNA Primers; D006233:Persons with Disabilities; D024881:Drug Resistance, Bacterial; D005260:Female; D005602:France / Q000453:epidemiology; D006784:Hospitals, Teaching; D006801:Humans; D007710:Klebsiella Infections / Q000453:epidemiology* / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000201:enzymology* / Q000235:genetics; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010957:Plasmids / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D017931:DNA Primers; C048795:AmpC beta-lactamases; D001618:beta-Lactamases