Palladium-catalyzed coupling of pyrazole triflates with arylboronic acids.
[reaction: see text] A general protocol for the palladium-mediated Suzuki coupling reaction of pyrazole triflates and aryl boronic acids has been developed. The use of additional dppf ligand was determined to increase product yields allowing for the use of a broad range of reaction substrates.
Dvorak
Curt A
CA
Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, California 92121, USA. cdvorak@prdus.jnj.com
Rudolph
Dale A
DA
Ma
Sandy
S
Carruthers
Nicholas I
NI