title: Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones.
abstract: The syntheses of a series of 2-arylindene-1-ones as potent ligands of ERbeta and ERalpha are described. Several compounds exhibited high potency and moderate selectivity for the ERbeta receptor. X-ray and modeling studies were used to understand ligand binding orientation and observed affinity.
authors.affiliation: Department of Chemical and Screening Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543-8000, USA. mcdevib@wyeth.com
authors.forename: Robert E
authors.initials: RE
authors.lastname: McDevitt
authors.forename: Michael S
authors.initials: MS
authors.lastname: Malamas
authors.forename: Eric S
authors.initials: ES
authors.lastname: Manas
authors.forename: Rayomand J
authors.initials: RJ
authors.lastname: Unwalla
authors.forename: Zhang B
authors.initials: ZB
authors.lastname: Xu
authors.forename: Chris P
authors.initials: CP
authors.lastname: Miller
authors.forename: Heather A
authors.initials: HA
authors.lastname: Harris
mesh_terms: D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology; D018360:Crystallography, X-Ray; D015195:Drug Design; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D047629:Estrogen Receptor beta / Q000378:metabolism*; D019833:Genistein / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007189:Indans / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D008024:Ligands; D008958:Models, Molecular; D011869:Radioligand Assay; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
chemical_list: C413384:1,2-indanedione; D000970:Antineoplastic Agents; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D007189:Indans; D008024:Ligands; D019833:Genistein