[Serum IL-2 and sIL-2R concentration in children with chronic hepatitis B].
The aim of the study was evaluation of serum IL-2 and sIL-2R concentration in children with chronic hepatitis B without previous treatment.


METHODS
Investigations were performed on sera from 27 children, 13 HBsAg and HBeAg positive (group I) and 14 HBsAg positive, HBeAg negative, anti-HBe positive (group II). Serum IL-2 and sIL-2R concentrations were detected with ELISA method.


RESULTS
In all examined children serum IL-2 concentrations were decreased. The mean values of sIL-2R in group I was 4,40 (from 1,78 to 15,74) and in group II was 2,60 ( from 1,59 to 4,81) ng/ ml and were statistically significant higher in HBeAg positive children (group I, p < 0.005). The mean ALT activity in this group of children was increased (mean 74 U/I) . The positive correlation between sIL-2R and ALT activity was observed in group I.


CONCLUSIONS
In children with chronic hepatitis B a deficiency of Th1 mediated immunological response was observed. HBeAg/anti-HBe seroconversion seems to change the IL-2/sIL-2R balance.
Pawłowska
Małgorzata
M
Katedra i Klinika Chorób Zakaźnych Akademii Medycznej w Bydgoszczy. kikchzak@amb.bydgoszcz.pl
Halota
Waldemar
W
Smukalska
Ewa
E
Grabczewska
Edyta
E
D000293:Adolescent; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006513:Hepatitis B e Antigens / Q000097:blood; D019694:Hepatitis B, Chronic / Q000097:blood*; D006801:Humans; D007376:Interleukin-2 / Q000097:blood*; D008297:Male; D015375:Receptors, Interleukin-2 / Q000097:blood*
D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D007376:Interleukin-2; D015375:Receptors, Interleukin-2