title: [Continuous enteral nutrition versus single bolus: effects on urine C peptide and nitrogen balance].
abstract: OBJECTIVE
  Our study was designed to assess the impact on nitrogen and glucose metabolism when it is administered either as discontinuous or as continuous infusion.
  
  
  METHODS
  We assessed the nutritional efficacy (nitrogen balance) and hyperinsulinism risk (urine C peptide excretion) of enteral nutrition in 23 patients hospitalized because of acute stroke.
  
  
  RESULTS
  The feeding tolerance of our enteral nutrition protocol (nasoenteric catheter) was full in every patient. The nitrogen balance was positive in both patterns, but the balance in the continuous feeding pattern was better than in the bolus feeding one. On the contrary, the urine C peptide excretion was increased when enteral nutrition was administered intermittently as compared with continuous feeding. Calciuria was greater in the continuous fed pattern than in the bolus feeding.
  
  
  CONCLUSIONS
  Continuous feeding is associated with better nitrogen balance and less urine C peptide excretion than intermittent feeding. These results suggest that continuous feeding would be an interesting choice to improve glucose control in diabetic patients with enteral nutrition.
authors.affiliation: Servicio de Endocrinología y Nutrición, Hospital Miguel Servet, Zaragoza, Spain. alesanz@arrakis.es
authors.forename: Alejandro
authors.initials: A
authors.lastname: Sanz París
authors.forename: Julio
authors.initials: J
authors.lastname: Lázaro
authors.forename: Ana
authors.initials: A
authors.lastname: Guallar
authors.forename: Paola
authors.initials: P
authors.lastname: Gracia
authors.forename: Alberto
authors.initials: A
authors.lastname: Caverni
authors.forename: Ramón
authors.initials: R
authors.lastname: Albero
mesh_terms: D000368:Aged; D002096:C-Peptide / Q000652:urine*; D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000628:therapy*; D004750:Enteral Nutrition / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D009584:Nitrogen / Q000378:metabolism*
chemical_list: D002096:C-Peptide; D009584:Nitrogen