title: The +276 polymorphism of the APM1 gene, plasma adiponectin concentration, and cardiovascular risk in diabetic men.
abstract: Recently, the genetic variability at adiponectin locus (APM1) was associated with cardiovascular risk in patients with type 2 diabetes. We sought to examine the associations of five variants of APM1 gene (C-11365G, A-4034C, A-3964G, T45G, and G276T) with the risk of cardiovascular diseases (CVDs) in a larger cohort of diabetic patients. Of 879 diabetic men from the Health Professionals Follow-up Study, 239 participants developed coronary heart disease or stroke during 14 years of follow-up and 640 CVD-negative subjects were used as control subjects. The risk of CVD was significantly lower in TT homozygotes at locus +276 than in other genotypes under a recessive inheritance model after adjusting for age, BMI, smoking, alcohol consumption, physical activity, aspirin use, HbA1c, and history of hypertension or hypercholesterolemia (odds ratio 0.38 [95% CI 0.18-0.79]; P = 0.009). In the CVD-negative control subjects, the allele 276T was associated with significantly higher plasma adiponectin levels in a dose-dependent pattern (GG 14.8, GT 16.2, and TT 18.8 microg/ml) after adjusting for age, BMI, and other variables (P for trend = 0.0019). In conclusion, our study showed significant associations between APM1 G276T and decreased CVD risk and increased plasma adiponectin levels in diabetic men.
authors.affiliation: Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave., Boston, MA 02115, USA. nhlqi@channing.harvard.edu
authors.forename: Lu
authors.initials: L
authors.lastname: Qi
authors.forename: Tricia
authors.initials: T
authors.lastname: Li
authors.forename: Eric
authors.initials: E
authors.lastname: Rimm
authors.forename: Cuilin
authors.initials: C
authors.lastname: Zhang
authors.forename: Nader
authors.initials: N
authors.lastname: Rifai
authors.forename: David
authors.initials: D
authors.lastname: Hunter
authors.forename: Alessandro
authors.initials: A
authors.lastname: Doria
authors.forename: Frank B
authors.initials: FB
authors.lastname: Hu
mesh_terms: D052242:Adiponectin; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000235:genetics*; D015331:Cohort Studies; D003925:Diabetic Angiopathies / Q000453:epidemiology* / Q000235:genetics*; D014644:Genetic Variation; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D052242:Adiponectin; D036341:Intercellular Signaling Peptides and Proteins