title: [Pharmacokinetics and distribution of superoxide dismutase liposomes in rats].
abstract: OBJECTIVE
  To evaluate the effects of surfactants on the pharmacokinetics and distribution in rats after intravenous administration of SOD liposomes.
  
  
  METHODS
  The liposomes were prepared by reverse phase evaporation method. The activity of SOD was assayed by method of xanthine oxidase.
  
  
  RESULTS
  The T1/2 of SOD solution, common SOD liposome, SOD liposomes modified by DSPE-PEG2000 and Tween 80 were 0.25, 0.34, 0.66 and 0.41 h, respectively; AUC were 12.48, 24.66, 41.16 and 33.02 microg x h x mL(-1), respectively. Compared with the common liposome, the liposomes modified by DSPE-PEG and Tween 80 decreased the content of SOD in liver and spleen, but increased in brain.
  
  
  CONCLUSIONS
  The three kinds of liposomes could increase T1/2 and AUC in some extent, especially in PEG-L group. Tween-L could increase the SOD content in brain, and PEG-L could decrease the SOD content in the liver and spleen compared with the common liposome.
authors.affiliation: Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China.
authors.forename: Yun-long
authors.initials: YL
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Xie
authors.forename: Hui-juan
authors.initials: HJ
authors.lastname: Wang
authors.forename: Xin-pu
authors.initials: XP
authors.lastname: Hou
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000818:Animals; D019540:Area Under Curve; D001921:Brain / Q000201:enzymology*; D007275:Injections, Intravenous; D008081:Liposomes; D008099:Liver / Q000201:enzymology; D008297:Male; D011136:Polysorbates / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013154:Spleen / Q000201:enzymology; D013482:Superoxide Dismutase / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D013501:Surface-Active Agents / Q000494:pharmacology; D014018:Tissue Distribution
chemical_list: D008081:Liposomes; D011136:Polysorbates; D013501:Surface-Active Agents; D013482:Superoxide Dismutase