title: Levels of anti-A/B antibodies after ABO-incompatible hematopoietic stem cell transplantation.
abstract: In contrast to solid organ transplantation, ABO incompatibility is generally not associated with survival differences in hematopoietic stem cell transplantation. Therefore, patients receiving ABO-incompatible stem cell transplantation can be analyzed to study the mechanism of tolerance induction after antigen-mismatched transplantation. The goal of this study was to analyze the levels of anti-A/B antibodies after ABO-incompatible transplantation. Host-derived antidonor antibodies disappeared rapidly after transplantation and did not reappear in the further posttransplant course. Donor-derived antihost antibodies did not significantly increase and compatible anti-A/B antibodies remained positive after hematopoietic stem cell transplantation. Thus, there is no evidence for stimulation of donor B lymphocytes to produce antirecipient antibodies suggesting a potential B cell tolerance.
authors.affiliation: Laboratory for Transplantation Immunology, University Hospital of Zürich, Switzerland.
authors.forename: G
authors.initials: G
authors.lastname: Stussi
authors.forename: K
authors.initials: K
authors.lastname: Huggel
authors.forename: U
authors.initials: U
authors.lastname: Schanz
authors.forename: J R
authors.initials: JR
authors.lastname: Passweg
authors.forename: J D
authors.initials: JD
authors.lastname: Seebach
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology*; D000741:Anemia, Aplastic / Q000276:immunology / Q000628:therapy; D001787:Blood Group Incompatibility / Q000209:etiology / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D006087:Graft vs Host Reaction / Q000276:immunology; D019337:Hematologic Neoplasms / Q000276:immunology / Q000628:therapy; D006789:Host vs Graft Reaction / Q000276:immunology; D006801:Humans; D033581:Stem Cell Transplantation / Q000009:adverse effects*
chemical_list: D000017:ABO Blood-Group System