title: Extended donor lungs: eleven years experience in a consecutive series.
abstract: OBJECTIVE
  The aim of this study was to delineate the profile of extended donor lungs in comparison to ideal donor lungs and to analyse their outcome. Particular attention was given to donor lungs with a low PaO(2) (<250mmHg) before harvesting or with multiple extended criteria.
  
  
  METHODS
  Between 1993 and 2003, 148 patients (79 women, 69 men, mean age 39.9 years) underwent lung transplantation. Indications were cystic fibrosis in 35.8%, emphysema in 26.4%, pulmonary fibrosis in 12.2%, pulmonary hypertension in 9.5%, and others in 16.1%. Donor data and recipients medical files were reviewed. Criteria for donor lungs were considered extended if one or more of the following criteria were met: age >55 years, smoking >20 pack-years, PaO(2) before harvesting <300mmHg, pathologic chest X-ray, and purulent secretion at bronchoscopy. A comparison between recipients from ideal and from extended donor lungs was performed with respect to the median duration of mechanical ventilation, the median length of stay at the intensive care unit, postoperative complications, the 30-day and the 1-year survival, and the 6-month follow-up spirometry.
  
  
  RESULTS
  Sixty-three (42.6%) donor lungs were considered extended and 20 (31.7%) met more than one criteria. Outcome comparison between recipients from ideal (I) and extended (II) donor lungs did not statistically differ in postoperative complications (18.8% (I) vs. 26.9% (II), P=0.32), mean duration of mechanical ventilation (d) (4.4+/-2.7 (I) vs. 2.6+/-2.1 (II), P=0.2), mean length of stay at the ICU (d) (11.5+/-8.8 (I) vs. 9.2+/-6.9 (II), P=0.4), 6-month pulmonary function (FEV1=83+/-23% of the predicted value (I) vs. 82+/-18% (II), P=0.81), 30-day survival (90.6% (I) vs. 93.7% (II), P=0.56), 1-year survival (83.5% (I) vs. 81% (II), P=0.83). Thirty-day survival was also comparable even in recipients from donor lungs with PaO(2)<250mmHg (n=8) (90.6% (I) vs. 87.5%, P=0.57). The number of extended criteria had no impact on the outcome. The combination of PaO(2)<300mmHg with purulent secretion at bronchoscopy seemed to influence the early outcome of recipients from extended donor lungs negatively.
  
  
  CONCLUSIONS
  Our results suggest that the use of selected extended donor lungs does not compromise the outcome after transplantation. PaO(2) <250mmHg before harvesting of the lungs is not an absolute contra-indication for transplantation.
authors.affiliation: Division of Thoracic Surgery, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland. didier.lardinois@chi.usz.ch <didier.lardinois@chi.usz.ch>
authors.forename: Didier
authors.initials: D
authors.lastname: Lardinois
authors.forename: Marc
authors.initials: M
authors.lastname: Banysch
authors.forename: Stephan
authors.initials: S
authors.lastname: Korom
authors.forename: Sven
authors.initials: S
authors.lastname: Hillinger
authors.forename: Valentin
authors.initials: V
authors.lastname: Rousson
authors.forename: Annette
authors.initials: A
authors.lastname: Boehler
authors.forename: Rudolf
authors.initials: R
authors.lastname: Speich
authors.forename: Walter
authors.initials: W
authors.lastname: Weder
mesh_terms: D000328:Adult; D000367:Age Factors; D003422:Critical Care; D046148:Donor Selection / Q000379:methods*; D005260:Female; D006801:Humans; D007902:Length of Stay; D008171:Lung Diseases / Q000601:surgery*; D016040:Lung Transplantation / Q000379:methods*; D008297:Male; D011183:Postoperative Complications; D012121:Respiration, Artificial; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D012907:Smoking; D016896:Treatment Outcome