Cardiac arrest/cardiopulmonary resuscitation augments cell-mediated immune function and transiently suppresses humoral immune function.
Immune system activation has implications for cerebrovascular health, but little is known about the function of the immune system after a major cerebrovascular event, such as cardiac arrest and cardiopulmonary resuscitation (CA/CPR). Cardiac arrest and cardiopulmonary resuscitation damages the hippocampus, an important component of the hypothalamic-pituitary-adrenal (HPA) axis, and alterations in HPA axis activity can affect immune function. We tested the hypothesis that CA/CPR (approximately 8 mins) would cause HPA axis dysregulation and alter the delayed type hypersensitivity (DTH) response to antigenic challenge. We also assessed the primary and secondary antibody response of mice exposed to CA/CPR. Of the mice exposed to CA/CPR, half had brains protected by hypothermia to isolate the effects of the CA/CPR procedure from the effects of CA/CPR-induced neuronal damage. Cardiac arrest and cardiopulmonary resuscitation-induced neuronal damage resulted in a persistent elevation of blood corticosterone concentration and a concomitant augmentation of the DTH response to antigenic challenge. Furthermore, immune activation before CA/CPR decreased survival after global ischemia. These data highlight the potential impact of neuronal damage on cell-mediated immune function and the role of humoral immune activation in outcome after global ischemia.
Neigh
Gretchen N
GN
Department of Psychology, The Ohio State University, Townshend Hall, Columbus, Ohio 43210, USA.
Glasper
Erica R
ER
Bilbo
Staci D
SD
Traystman
Richard J
RJ
Courtney DeVries
A
A
D000818:Animals; D000917:Antibody Formation / Q000276:immunology; D000941:Antigens / Q000276:immunology; D016887:Cardiopulmonary Resuscitation / Q000379:methods; D003345:Corticosterone / Q000097:blood / Q000276:immunology; D006323:Heart Arrest / Q000097:blood / Q000276:immunology* / Q000628:therapy; D006624:Hippocampus / Q000276:immunology* / Q000293:injuries / Q000378:metabolism; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology* / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000276:immunology* / Q000378:metabolism; D007035:Hypothermia / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control; D007111:Immunity, Cellular / Q000276:immunology; D007511:Ischemia / Q000097:blood / Q000276:immunology; D008297:Male; D051379:Mice; D009474:Neurons / Q000276:immunology / Q000378:metabolism; D010913:Pituitary-Adrenal System / Q000276:immunology* / Q000378:metabolism
D000941:Antigens; D003345:Corticosterone