Novel insights into c-Src.
Since identifying a transmissible agent responsible for tumorigenesis in chickens, the v-Src oncogene, significant progress has been made in determining the functions of its cellular homologue. c-Src is the product of the SRC gene and has been found both over-expressed and highly activated in a number of human cancers. In fact the relationship between c-Src activation and cancer progression is significant. Furthermore c-Src may play a role in the acquisition of the invasive and metastatic phenotype. In this review we will summarize some of the latest evidence for the role of c-Src in tumorigenesis and particularly in human tumor progression. In this review, specifically, we will address growth signals, adhesion, migration, invasion, angiogenesis and functional genomics.
Alper
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National Institute of Health, National Institute of Neurological Disorders, Surgical Neurology, Bldg. 10, Rm. 5D37, Bethesda, MD 20892-1414, USA. alpero@mail.nih.gov
Bowden
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D000818:Animals; D018450:Disease Progression; D016391:Genes, src / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D016392:Proto-Oncogene Proteins pp60(c-src) / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*
D016392:Proto-Oncogene Proteins pp60(c-src)