Polyoma BK virus reactivation in kidney and pancreas-kidney recipients.
BK virus infection has become important factor affecting graft function in renal transplant recipients. One of the most important complication of BK infection is nephropathy in patients after renal transplantation. The aim of this study was to evaluate incidence of BK reactivation and nephropathy in our population of renal allograft recipients. One hundred twelve renal or pancreas-kidney allograft recipients were included for the 24 months follow-up. The incidence of BK nephropathy was 7.85% and viremia 27.96%. In the second study group there were 28 patients with graft function deterioration evaluated at the time of biopsy. In this group incidence of BK nephropathy was 7.1% and viral reactivation was diagnosed in 10.7% of patients. In our center, the incidence of BK nephropathy is the same as worldwide. The risk of BK virus replication is highest during first 15 months after the surgical procedure.
Matłosz
B
B
Department of Transplantation Medicine and Nephrology, Warsaw Medical School, Warsaw, Poland.
Durlik
M
M
Wesołowska
A
A
Mróz
A
A
Zegarska
J
J
Rowiński
W
W
Szmidt
J
J
D001739:BK Virus / Q000502:physiology*; D004279:DNA, Viral / Q000032:analysis; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000473:pathology; D016035:Pancreas Transplantation / Q000009:adverse effects*; D027601:Polyomavirus Infections / Q000453:epidemiology*; D012008:Recurrence; D012189:Retrospective Studies; D014412:Tumor Virus Infections / Q000453:epidemiology*; D014766:Viremia / Q000453:epidemiology; D014775:Virus Activation / Q000502:physiology*
D004279:DNA, Viral