Longitudinal study of birth weight and adult body mass index in predicting risk of coronary heart disease and stroke in women.
OBJECTIVE
To determine whether birth weight and adult body size interact to predict coronary heart disease in women, as has been observed for men. To determine whether birth weight and adult body size interact to predict risk of stroke.


METHODS
Longitudinal cohort study.


METHODS
66,111 female nurses followed since 1976 who were born of singleton, term pregnancies and reported their birth weight in 1992.


METHODS
1504 events of coronary heart disease (myocardial infarction or sudden cardiac death) and 1164 strokes.


RESULTS
For each kilogram of higher birth weight, age adjusted hazard ratios from prospective analysis were 0.77 (95% confidence interval 0.69 to 0.87) for coronary heart disease and 0.89 (0.78 to 1.01) for total stroke. In combined prospective and retrospective analysis, hazard ratios were 0.84 (0.76 to 0.93) for total stroke, 0.83 (0.71 to 0.96) for ischaemic stroke, and 0.86 (0.66 to 1.11) for haemorrhagic stroke. Exclusion of macrosomic infants (> 4536 g) yielded stronger estimates. Risk of coronary heart disease was especially high for women who crossed from a low centile of weight at birth to a high centile of body mass index in adulthood. The association of lower birth weight with increased risk of stroke was apparent across categories of body mass index in adults and was not especially strong among heavier women.


CONCLUSIONS
Higher body mass index in adulthood is an especially strong risk factor for coronary heart disease among women who were small at birth. In this large cohort of women, size at birth and adiposity in adulthood interacted to predict events of coronary heart disease but not stroke events.
Rich-Edwards
Janet W
JW
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Avenue, Boston, MA 02215, USA. janet_rich-edwards@hphc.org
Kleinman
Ken
K
Michels
Karin B
KB
Stampfer
Meir J
MJ
Manson
JoAnn E
JE
Rexrode
Kathryn M
KM
Hibert
Eileen N
EN
Willett
Walter C
WC
D000293:Adolescent; D001724:Birth Weight; D015992:Body Mass Index; D015331:Cohort Studies; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008137:Longitudinal Studies; D009203:Myocardial Infarction / Q000209:etiology*; D018570:Risk Assessment; D012307:Risk Factors; D020521:Stroke / Q000209:etiology*