[Influence of repeated platelet donation on megakaryopoiesis in donors].
To explore influence of platelet donation on donor's megakaryocytopoiesis, platelet counts and plasma concentrations of thrombopoietin (TPO), interleukin-3 (IL-3), IL-6 and nitric oxide (NO) were determined in 42 frequent platelet donors (undergoing plateletpheresis more than once a month for 24 months and their mean platelet yield of collection was 2.5 x 10(11)), in 62 limited platelet donors (undergoing plateletpheresis less than once a month for 24 months) after a donation-free period of > 5 weeks and in 40 whole blood donors who never undergoing plateletpheresis after a donation-free period of > 6 months. The results showed that the TPO levels was significantly lower in frequent platelet donors than in limited platelet donors (P < 0.01) and whole blood donors (P < 0.01). There were no significant differences between three groups in platelet counts, IL-3, IL-6 and NO. These findings suggest that the number of megakarocytes significantly increased in frequent platelet donors.
Dai
Yu-Dong
YD
Nanjing Red Cross Blood Center, Nanjing 210003, China.
Sun
Qi-Jun
QJ
Meng
Bo
B
Xu
Shu-Liang
SL
D000328:Adult; D001782:Blood Donors; D006801:Humans; D007377:Interleukin-3 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008533:Megakaryocytes / Q000166:cytology; D010976:Platelet Count; D010983:Plateletpheresis / Q000009:adverse effects*; D034061:Thrombopoiesis; D013926:Thrombopoietin / Q000097:blood
D007377:Interleukin-3; D015850:Interleukin-6; D013926:Thrombopoietin