[Expression of c-FOS protein in rat hippocampus by inducing of mercury contaminated rice].
In order to probe into the biological effects of mercury in typical mercury contaminated area and try to apply the expression of immediately early gene c-fos in brain to early predict the neurotoxicity of mercury in typical polluted areas, the expression of c-FOS protein in rat hippocampus is observed using immunocytochemical methods. The results show the mercury pollutes rice induced significantly the expression of c-FOS protein in hippccampus;the antagonisis between selenium and mercury on the exposure process. It is suggested that c-fos can be used as an effective index of detecting and assessing neurotoxicology of mercury polluted areas.
Cheng
Jin-ping
JP
School of Environmental Science and Engineering, Shanghai Jiaotong University, Shanghai 200240, China.
Wang
Wen-hua
WH
Qu
Li-ya
LY
Jia
Jin-ping
JP
Zheng
Min
M
D000818:Animals; D005260:Female; D005506:Food Contamination / Q000032:analysis*; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D008628:Mercury / Q000633:toxicity*; D012275:Oryza; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis* / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley
D016760:Proto-Oncogene Proteins c-fos; D008628:Mercury