Obstetric outcome of patients with polycystic ovary syndrome treated by in vitro maturation and in vitro fertilization-embryo transfer.
OBJECTIVE
To assess the obstetric outcome of pregnancies resulting from in vitro maturation (IVM) and IVF-ET of immature oocytes retrieved from women with polycystic ovary syndrome (PCOS).


METHODS
Prospective observational study.


METHODS
University fertility clinic.


METHODS
One hundred thirty-nine women undergoing 203 IVM treatment cycles.


METHODS
Immature oocyte recovery from unstimulated ovaries. In vitro oocyte maturation and fertilization. Fresh ET and assessment of obstetric outcomes in the pregnant women.


METHODS
Pregnancy and obstetric outcome.


RESULTS
Forty-one pregnancies were obtained in 187 ETs, resulting in a pregnancy rate of 21.9%. Except for three patients lost to follow-up in these pregnancies, the abortion and live birth rates were 36.8% (14 of 38) and 63.2% (24 of 38), respectively. The mean (+/-SD) gestational age and birth weight at delivery for singletons were 38.4 +/- 2.0 weeks (range, 33-41.6 weeks) and 3,252 +/- 516 g (1,750-4,100 g), respectively. For twins these were 36.7 +/- 1.9 weeks (34.6-39 weeks) and 2,361 +/- 304 g (1,900-2,990 g), respectively. Pregnancy complications occurred in five patients (13.2%); these included preterm labor (n = 3) and placenta previa (n = 2). Two patients (5.3%) had a major congenital anomaly diagnosed by ultrasonography.


CONCLUSIONS
The abortion rate, gestational age and birth weight at delivery, and obstetric complications of pregnancies conceived by IVM-ET in women with PCOS were comparable with those of other women with PCOS being treated by conventional IVF-ET. In vitro maturation followed by IVF-ET seems to be a useful treatment option for women with PCOS, thus avoiding the risk of ovarian hyperstimulation syndrome.
Cha
Kwang Yul
KY
Infertility Medical Center of CHA General Hospital, CHA Research Institute, Pochon CHA University, Seoul, Korea.
Chung
Hyung Min
HM
Lee
Dong Ryul
DR
Kwon
Hwang
H
Chung
Mi Kyung
MK
Park
Lee Suk
LS
Choi
Dong Hee
DH
Yoon
Tae Ki
TK
D000328:Adult; D004624:Embryo Transfer / Q000706:statistics & numerical data*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods / Q000706:statistics & numerical data*; D006801:Humans; D009865:Oocytes / Q000502:physiology*; D011085:Polycystic Ovary Syndrome / Q000453:epidemiology* / Q000628:therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D018873:Pregnancy Rate; D011446:Prospective Studies