A physiological model of cerebral blood flow control.
The construction of a computational model of the human brain circulation is described. We combine an existing model of the biophysics of the circulatory system, a basic model of brain metabolic biochemistry, and a model of the functioning of vascular smooth muscle (VSM) into a single model. This represents a first attempt to understand how the numerous different feedback pathways by which cerebral blood flow is controlled interact with each other. The present work comprises the following: Descriptions of the physiology underlying the model; general comments on the processes by which this physiology is translated into mathematics; comments on parameter setting; and some simulation results. The simulations presented are preliminary, but show qualitative agreement between model behaviour and experimental results.
Banaji
Murad
M
Department of Medical Physics and Bioengineering, University College London, Gower Street, London WC1E 6BT, UK. m.banaji@ucl.ac.uk
Tachtsidis
Ilias
I
Delpy
David
D
Baigent
Stephen
S
D000465:Algorithms; D001808:Blood Vessels / Q000502:physiology; D001921:Brain / Q000098:blood supply*; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D009131:Muscle, Smooth, Vascular / Q000098:blood supply; D012039:Regional Blood Flow / Q000502:physiology