title: Epidermodysplasia verruciformis in two half brothers with HIV infection.
abstract: BACKGROUND
  Epidermodysplasia verruciformis (EV) is a rare disorder characterized by widespread flat and common verrucae. From 25% to 50% of EV cases are inherited, usually with an autosomal recessive pattern. An X-linked inheritance has also been reported. Many EV patients have a cellular immunity defect. HIV-associated lesions have been found to contain HPV-5, HPV-8, and HPV-20.
  
  
  OBJECTIVE
  We describe two HIV-positive Hispanic maternal half brothers who presented with asymptomatic polyangular papules and plaques on the face, trunk, and extremities and which first appeared 4-5 years prior. The histopathology is consistent with EV. HPV-8 was detected by in situ hybridization. The patients were treated with topical imiquimod for two months without improvement.
  
  
  CONCLUSIONS
  To our knowledge, this is the first reported case of epidermodysplasia verruciformis in HIV-positive pediatric patients.
authors.affiliation: Department of Dermatology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio 44109, USA .
authors.forename: Weimin
authors.initials: W
authors.lastname: Hu
authors.forename: Gerard
authors.initials: G
authors.lastname: Nuovo
authors.forename: Marlene
authors.initials: M
authors.lastname: Willen
authors.forename: Stephen
authors.initials: S
authors.lastname: Somach
mesh_terms: D002648:Child; D004819:Epidermodysplasia Verruciformis / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D015658:HIV Infections / Q000150:complications / Q000151:congenital* / Q000188:drug therapy; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D035781:Siblings