title: Influence of juxtapapillary diverticulum on hepatic clearance in patients after endoscopic sphincterotomy.
abstract: OBJECTIVE
  The role of juxtapapillary diverticulum ( JPD) in biliary stone formation is controversial. This study was designed to understand the relationship between the size of JPD, hepatic clearance and recurrent bile duct stones in patients after endoscopic sphincterotomy.
  
  
  METHODS
  Five hundred and twenty patients with choledocholithiasis who had received endoscopic sphincterotomy were enrolled. They were divided into three groups: group A (n = 268) without diverticula; group B (n = 156) with small diverticula; and group C (n = 96) with large diverticula. All patients were regularly followed with interviews, liver function test and sonogram to detect the recurrent bile duct stones. Quantitative cholescintigraphy was performed in 176 cholecystectomized patients to evaluate the hepatic clearance. Sphincter of Oddi manometry was performed to exclude incomplete sphincterotomy if quantitative cholescintigraphy was abnormal.
  
  
  RESULTS
  After 9-111 months of follow-up, 76 patients had recurrent bile duct stones. There was a significant higher bile duct stone recurrence in group C than in group A (P < 0.01), but no statistical difference was noted between group B and group A (P = 0.2). Patients with JPD were older than those without (P < 0.05). Of 176 cholecystectomized patients, two were excluded because sphincter of Oddi basal pressure was more than 10 mmHg. In the remaining 174 patients, the E45' was significantly lower in group C than in group A (41.2% +/- 18.6%vs 49.1% +/- 14.1%; P < 0.05), and there was no significant difference between group B and group A.
  
  
  CONCLUSIONS
  JPD is a predisposing factor of delayed biliary emptying and it increases the chance and incidence of recurrent bile duct stones.
authors.affiliation: Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
authors.forename: Jeng-Jie
authors.initials: JJ
authors.lastname: Tzeng
authors.forename: Kwok-Hung
authors.initials: KH
authors.lastname: Lai
authors.forename: Nan-Jing
authors.initials: NJ
authors.lastname: Peng
authors.forename: Gin-Ho
authors.initials: GH
authors.lastname: Lo
authors.forename: Chiun-Ku
authors.initials: CK
authors.lastname: Lin
authors.forename: Hoi-Hung
authors.initials: HH
authors.lastname: Chan
authors.forename: Ping-I
authors.initials: PI
authors.lastname: Hsu
authors.forename: Jin-Shiung
authors.initials: JS
authors.lastname: Cheng
authors.forename: E-Ming
authors.initials: EM
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014670:Ampulla of Vater; D004240:Diverticulum / Q000150:complications / Q000000981:diagnostic imaging* / Q000378:metabolism; D004378:Duodenal Diseases / Q000150:complications / Q000000981:diagnostic imaging* / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D042882:Gallstones / Q000000981:diagnostic imaging* / Q000209:etiology / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012008:Recurrence; D016717:Sphincterotomy, Endoscopic; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid / Q000493:pharmacokinetics
chemical_list: D019275:Radiopharmaceuticals; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid