Mechanism of proliferation arrest of embryonic cells of Xenopus by diterpene compounds.
Three diterpene compounds isolated from the anti-cancer herbal medicine kansui, namely, kansuinin B, 20-OD-ingenol Z, and 20-OD-ingenol E, specifically inhibited the proliferation of isolated embryonic cells from Xenopus embryos. We conducted a cytologic study to determine the mechanism underlying the arrest of the cellular proliferation by these compounds. While kansuinin B and 20-OD-ingenol Z treatment decreased the cell numbers in the S phase and the M phase substages of the cell cycle, 20-OD-ingenol E inhibited mitosis.
Okouchi
Tomoharu
T
Laboratory of Biochemistry, Department of Chemistry, College of Humanities and Sciences, Nihon University, 3-25-40 Sakurajosui, Setagaya-ku, Tokyo 156-8550, Japan.
Abe
Tetsuya
T
Araki
Shusuke
S
Arai
Shinsuke
S
Iida
Takashi
T
Wang
Li-Yan
LY
Kitanaka
Susumu
S
Miyata
Shohei
S
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D004224:Diterpenes / Q000494:pharmacology*; D005260:Female; D008297:Male; D016196:S Phase / Q000187:drug effects; D014982:Xenopus laevis / Q000196:embryology*
D004224:Diterpenes