Arylamide dendrimers with flexible linkers via haloacyl halide method.
[reaction: see text] Soluble arylamide dendrons with flexible linkers, peripheral ester or carboxyl groups (R), and focal amino or halogen functionalities (F) were synthesized from aryl glycineamide (AG) building blocks. The AG blocks were prepared in high yields from trivial starting materials by Fischer's haloacyl halide method, which also could be extended to the dendrimer synthesis itself. The G2 AG dendrons were coupled to a Pd porphyrin core, demonstrating outstanding encapsulation efficiency in aqueous solutions.
Vinogradov
Sergei A
SA
Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. vinograd@mail.med.upenn.edu
D005998:Glycine / Q000737:chemistry; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis*; D008665:Metalloporphyrins / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis*
D006846:Hydrocarbons, Halogenated; D008665:Metalloporphyrins; D011108:Polymers; D010165:Palladium; D005998:Glycine