Pharmacokinetics of tenofovir in breast milk of lactating rhesus macaques.
To study tenofovir transfer into milk, two lactating macaques were given a subcutaneous dose of tenofovir (30 mg/kg of body weight). Peak concentrations and area under the curve values of tenofovir in milk were approximately 3 and approximately 20% of those detected in serum, respectively.
Van Rompay
Koen K A
KK
California National Primate Research Center, University of California, Davis, CA 95616, USA. kkvanrompay@ucdavis.edu
Hamilton
Marta
M
Kearney
Brian
B
Bischofberger
Norbert
N
D000225:Adenine / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D019380:Anti-HIV Agents / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D005260:Female; D006207:Half-Life; D008253:Macaca mulatta; D008892:Milk / Q000737:chemistry / Q000378:metabolism*; D063065:Organophosphonates / Q000097:blood / Q000493:pharmacokinetics*; D010865:Pilot Projects; D000068698:Tenofovir
D019380:Anti-HIV Agents; D063065:Organophosphonates; D000068698:Tenofovir; D000225:Adenine