[Effects of perfluorooctane sulfonate on spermiogenesis function of male rats].
OBJECTIVE
To evaluate the effects of administration of perfluorooctane sulfonate(PFOS) on spermiogenesis function of male rats.


METHODS
36 male rats were randomly divided into 4 groups, which received 0, 0.5, 1.5, 4.5 mg x kg(-1) PFOS by food intake per day for 65 days. The testicular and epididymal viscera coefficients, the number, motility and deformity of sperm were examined. The activities of lactate dehydrogenase isoenzyme-x (LDHx), sorbitol dehydrogenase (SDH) and the generation of malonyldialdehyde (MDA) in the testes were also measured.


RESULTS
The viscera coefficients did not show any significant change ( P > 0.05) while the body weight and weight of testis decreased ( P < 0.05) in treated rats compared with the corresponding control group animals. In 1.5,4.5 mg x kg(-1) PFOS treated rats there were significant decreases in the sperm count (P < 0.05) and the mean activities of LDHx and SDH whereas obvious increases in the rate of sperm deformity ( P < 0.05). In 4.5 mg x kg(-1) PFOS group the generation of MDA increased (P < 0.05) while the motility of sperm reduced (P < 0.05) with respect to the control value.


CONCLUSIONS
It suggested that PFOS could elicit the impairment of sperm production and maturation of male rats.
Fan
Yi-Ou
YO
School of Public Health, China Medical University, Shenyang 110001, China.
Jin
Yi-He
YH
Ma
Yi-Xin
YX
Zhang
Ying-Hua
YH
D017738:Alkanesulfonic Acids / Q000633:toxicity*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005466:Fluorocarbons / Q000633:toxicity*; D007527:Isoenzymes / Q000378:metabolism; D007064:L-Iditol 2-Dehydrogenase / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D013093:Spermatogonia / Q000187:drug effects*
D017738:Alkanesulfonic Acids; D005466:Fluorocarbons; D007527:Isoenzymes; D008315:Malondialdehyde; C076994:perfluorooctane sulfonic acid; D007064:L-Iditol 2-Dehydrogenase; D007770:L-Lactate Dehydrogenase; C409673:lactate dehydrogenase C4