6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid mimics active conformation of tyrosine in opioid peptides.
6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (6Htc) has been proposed as a rigid mimic of tyrosine conformation in opioid ligand-receptor complex. The significant receptor binding to mu and delta opioid receptors of respective analogues of deltorphin, dermorphin, and endomorphin with D,L-6Htc prove initial prediction.
Sperlinga
Emanuela
E
Department of Pharmaceutical Sciences, University of Catania, Catania 95125, Italy.
Kosson
Piotr
P
Urbanczyk-Lipkowska
Zofia
Z
Ronsisvalle
Giuseppe
G
Carr
Daniel B
DB
Lipkowski
Andrzej W
AW
D002264:Carboxylic Acids / Q000737:chemistry*; D018360:Crystallography, X-Ray; D007546:Isoquinolines / Q000737:chemistry*; D015394:Molecular Structure; D018847:Opioid Peptides / Q000737:chemistry*; D011957:Receptors, Opioid / Q000737:chemistry; D014443:Tyrosine / Q000737:chemistry*
D002264:Carboxylic Acids; D007546:Isoquinolines; D018847:Opioid Peptides; D011957:Receptors, Opioid; D014443:Tyrosine