title: Determination of ambroxol in an automated multi-pumping pulsed flow system.
abstract: A new flow methodology exploiting the multi-pumping approach was developed for the spectrophotometric determination of ambroxol hydrochloride in pharmaceutical preparations. The flow manifold was implemented by using, exclusively, multiple solenoid-actuated micro-pumps, which acted simultaneously as sample insertion, solutions propelling and reagents commutation units. Linear calibration plots were obtained over an ambroxol concentration ranging from 10 to 200 mg l(-1) (r.s.d. < 0.5%, n = 15) and a sampling rate of about 60 samples per hour (flow rate = 1.92 ml min(-1), sample volume = 80 microl).
authors.affiliation: REQUIMTE, Departamento de Química-Fisica, Faculdade de Farmácia, Universidade do Porto, Rua Anibal Cunha 164, 4050-047 Porto, Portugal. joaolms@ff.up.pt
authors.forename: João L M
authors.initials: JL
authors.lastname: Santos
authors.forename: Arnaud
authors.initials: A
authors.lastname: Clausse
authors.forename: José L F C
authors.initials: JL
authors.lastname: Lima
authors.forename: M L M F S
authors.initials: ML
authors.lastname: Saraiva
authors.forename: António O S
authors.initials: AO
authors.lastname: Rangel
mesh_terms: D000551:Ambroxol / Q000032:analysis*; D002138:Calibration; D005100:Expectorants / Q000032:analysis*; D017022:Flow Injection Analysis; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D012996:Solutions
chemical_list: D005100:Expectorants; D007202:Indicators and Reagents; D012996:Solutions; D000551:Ambroxol