title: [The effects of portal vein microscopic and macroscopic tumor thrombi on post-operation patients with hepatocellular carcinoma].
abstract: OBJECTIVE
  To evaluate the effects of portal vein microscopic and macroscopic tumor thrombi on post-operation patients with hepatocellular carcinoma (HCC).
  
  
  METHODS
  Three thousand three hundred and forty eight HCC patients were retrospectively reviewed, which were divided into no portal vein tumor thrombi (PVTT), microscopic PVTT and macroscopic PVTT groups according to the pathology, effects of portal vein microscopic and macroscopic tumor thrombi on post-operation patients's survival were studied by univariate analysis and overall survival was evaluated in each group.
  
  
  RESULTS
  Hazard ratio (HR) of portal vein microscopic tumor thrombi and macroscopic tumor thrombi was 1.421 and 3.136 respectively; The overall 1-, 3-, 5- and 10-year cumulative survival rate was 85.97%, 62.78%, 49.88% and 35.42% respectively, and mean time for survival was 59.7 months in group without PVTT, while 74.42%, 51.66%, 39.25% and 27.28% respectively and mean time for survival 39.1 months in group with microscopic PVTT, 52.59%, 25.97%, 20.42% and 11.33% respectively and mean time for survival 13.5 months in group with macroscopic PVTT.
  
  
  CONCLUSIONS
  PVTT was an important prognostic factor for survival in post-operation patients with HCC while macroscopic PVTT was more danger than microscopic PVTT. The period of microscopic PVTT was the landmark affecting post-operation survival.
authors.affiliation: Institute of Liver Cancer, Department of Hepatic Surgery, Zhongshan Hospital of Fudan University, Shanghai 200032, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Fan
authors.forename: Zhao-you
authors.initials: ZY
authors.lastname: Tang
authors.forename: Zhi-quan
authors.initials: ZQ
authors.lastname: Wu
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
authors.forename: Xin-da
authors.initials: XD
authors.lastname: Zhou
authors.forename: Zeng-chen
authors.initials: ZC
authors.lastname: Ma
authors.forename: Lun-xiu
authors.initials: LX
authors.lastname: Qin
authors.forename: Shuang-jian
authors.initials: SJ
authors.lastname: Qiu
authors.forename: Yao
authors.initials: Y
authors.lastname: Yu
authors.forename: Cheng
authors.initials: C
authors.lastname: Huang
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D009360:Neoplastic Cells, Circulating; D011169:Portal Vein / Q000473:pathology*; D012189:Retrospective Studies; D015996:Survival Rate