[The influence of early vascular rejection on late rejection in first cadaveric renal transplantation].
OBJECTIVE
To explore the influence of early completely reversal vascular rejection on late rejection.


METHODS
The data of 1062 patients who received their first cadaveric transplants between May 1988 and March 2003 were analyzed respectively. The patients were divided into 2 groups: group with vascular rejection occurring within 1 month postoperatively (n = 45), and group without vascular rejection (n = 1017). Follow up was performed for at least 6 months. The influence of demographic characteristics (transplant age, sex), transplant variables (complement dependent cytotoxicity test, cold/warm ischemia time), and post-transplant variables (immunosuppressive agents for the prevention of acute rejection,) were analyzed.


RESULTS
There were no differences in the age at transplantation, sex, complement dependent cytotoxicity test, cold/warm ischemia time, immunosuppression agent protocol, and serum creatinine during follow-up between the recipients of these two groups. Late rejection, including acute interstitial rejection, borderline rejection, and chronic rejection, occurring one month after transplantation was 2.22% (1/45) in the vascular rejection group, significantly lower than that of the no vascular rejection group (12.59%, 128/1017, P = 0.034)


CONCLUSIONS
Early completely reversal vascular rejection can reduce the rate of late rejection.
Chen
Jiang-hua
JH
Nephrology Center, the First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310003, China.
Wang
Ren-ding
RD
Wu
Jian-yong
JY
Wang
Yi-min
YM
Zhu
Cong
C
Zhang
Jian-guo
JG
Wang
Su-ya
SY
Zhang
Ping
P
Huang
Hong-feng
HF
He
Qiang
Q
D000328:Adult; D002102:Cadaver; D002681:China / Q000453:epidemiology; D005260:Female; D006084:Graft Rejection / Q000145:classification / Q000453:epidemiology*; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D012189:Retrospective Studies; D013997:Time Factors