Hypermutable and fluoroquinolone-resistant clinical isolates of Staphylococcus aureus.
Over 124 methicillin-susceptible Staphylococcus aureus 0/74 fluoroquinolone-susceptible versus 5/50 fluoroquinolone-resistant isolates were hypermutable. Hypermutable isolates combined mutations in gyrA, parC, and/or parE genes. One strain had a large deletion of the mutator mutS and mutL genes. No relevant mutation in mutS and mutL genes was found in the other isolates.
Trong
Hiep N'Guyen
HN
Service de Microbiologie and EA 2128 Relations hôte et microorganismes des épithéliums, Hôpital Côte de Nacre, Université de Caen, 14033 Caen Cedex, France.
Prunier
Anne-Laure
AL
Leclercq
Roland
R
D000890:Anti-Infective Agents / Q000494:pharmacology*; D017931:DNA Primers; D004261:DNA Replication; D024881:Drug Resistance, Bacterial; D024841:Fluoroquinolones / Q000494:pharmacology*; D005798:Genes, Bacterial / Q000235:genetics; D016106:Methicillin Resistance; D009154:Mutation / Q000235:genetics / Q000502:physiology; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics*
D000890:Anti-Infective Agents; D017931:DNA Primers; D024841:Fluoroquinolones