Elevated plasma homocysteine level in slow coronary flow.
BACKGROUND
Slow flow velocity of dye in coronary arteries is not an infrequent finding during routine coronary angiography and its precise mechanism is unknown. In this study, we measured the plasma homocysteine level in patients with slow coronary flow (SCF) in comparison with subjects having normal coronary flow (NCF).


METHODS
The study consisted 39 patients (mean age, 47+/-8 years) with angiographically diagnosed SCF. SCF was defined according to TIMI frame count (TFC) method. Thirty subjects (mean age 46+/-8 years) with NCF served as control group. Plasma homocysteine levels were measured after 12 h fasting period in each subject.


RESULTS
Baseline demographic properties were similar in both groups. In patients with SCF, TFC was significantly higher than those with NCF. Similarly, in patients with SCF plasma homocysteine level was significantly higher than that of control group (14.1+/-2.2 vs. 5.5+/-1.3 micromol/l, respectively p < 0.001).


CONCLUSIONS
Elevated plasma homocysteine level supports the hypothesis that endothelial function is impaired in slow coronary flow.
Barutcu
Irfan
I
Sezgin
Alpay Turan
AT
Sezgin
Nurzen
N
Gullu
Hakan
H
Esen
Ali Metin
AM
Topal
Ergun
E
Ozdemir
Ramazan
R
D016022:Case-Control Studies; D003326:Coronary Circulation / Q000502:physiology*; D003331:Coronary Vessels / Q000503:physiopathology*; D004727:Endothelium / Q000098:blood supply / Q000503:physiopathology; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D014664:Vasodilation / Q000502:physiology
D006710:Homocysteine