[Toxicokinetics of tetramethylene disulphotetramine].
OBJECTIVE
To explore toxicokinetics of tetramethylene disulphotetramine (TETS) in rabbit and the effects on toxicokinetics of TETS after activated charcoal by gavage.


METHODS
Eight rabbits were exposed through gavage and vein respectively, the blood samples were collected from the center artery in ear of rabbit at an arranged time. Four rabbits were exposed after being intubated into urethra and common bile duct. The samples of bile and urine were collected at arranged times. After being exposed by gavage, activated charcoal (1 g/kg) was administrated in the activated charcoal group and the distilled water (1 g/kg) administrated to the controls. The samples of blood were collected from the center artery in ear of rabbit at arranged times. The contents of TETS in samples were determined by GC/NPD method. Analysed by the 3p87 soft, toxicokinetics parameters of TETS were acquired.


RESULTS
TETS was eliminated very slowly in rabbit. The plasma half time in elimination phase (Tke1/2) of TETS was 56.9 hours in vein exposure group and 262.5 hours in oral exposure group respectively. The plasma clearance (CL) of it was only 15.4 ml.kg(-1).h(-1) in oral exposure group and 24.1 ml.kg(-1).h(-1) in vein exposure group. TETS was eliminated from urine in rabbit. The eliminated amount of it from urine was more 5 times than from bile. All parameters of toxicokinetics of TETS were significantly different between the activated charcoal group and the control. Compared to the control, Tke1/2 of TETS in the activated charcoal group was equal to 55%, CL was increased over 3-fold, area under the curve was equal to 30%.


CONCLUSIONS
TETS was a poison eliminated very slowly in body. The eliminated amount of it from urine was more than from bile. The excretion of TETS could be quickened after activated charcoal by gavage.
Zhang
Hong-shun
HS
National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Zhou
Jing
J
Zhang
Shou-lin
SL
Wu
Yi-qun
YQ
Sun
Cheng-ye
CY
D000818:Animals; D000931:Antidotes / Q000008:administration & dosage; D001646:Bile / Q000378:metabolism; D001952:Bridged-Ring Compounds / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D002606:Charcoal / Q000008:administration & dosage*; D005260:Female; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D011817:Rabbits
D000931:Antidotes; D001952:Bridged-Ring Compounds; D002606:Charcoal; C010349:tetramethylenedisulfotetramine