Interleukin-15 decreases lipid intestinal absorption.
Administration of a single acute intravenous injection of interleukin-15 (IL-15) (100 microg/kg bw) to rats resulted in a significant decrease (22%) in triacylglycerol absorption, as measured by using [14C]-triolein load. The cytokine, however, did not influence the oxidation of the exogenously administered lipid or the tissue uptake of [14C]-triolein; this is in concordance with the lack of effects found in the measurement of the tissue lipoprotein lipase activity. Concerning the mechanism involved in the decreased intestinal absorption associated with IL-15 administration, the results presented clearly demonstrate that changes in gastric emptying and intestinal mobility are not involved, as the effect is specific for triacylglycerols. In conclusion, intestinal absorption may be an additional mechanism to take into consideration to explain the 'anti-fat' effect of this cytokine.
Almendro
Vanessa
V
Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.
Carbó
Neus
N
Busquets
Sílvia
S
López-Soriano
Joaquín
J
Figueras
Maite
M
Ametller
Elisabet
E
Argilés
Josep M
JM
López-Soriano
Francisco J
FJ
D000818:Animals; D002250:Carbon Radioisotopes; D004032:Diet; D019409:Interleukin-15 / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology*; D007408:Intestinal Absorption / Q000187:drug effects*; D050356:Lipid Metabolism; D008071:Lipoprotein Lipase / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000378:metabolism; D014304:Triolein / Q000378:metabolism
D002250:Carbon Radioisotopes; D019409:Interleukin-15; D014280:Triglycerides; D014304:Triolein; D008071:Lipoprotein Lipase