title: Prevalence and characterization of invasive isolates of Streptococcus pyogenes with reduced susceptibility to fluoroquinolones.
abstract: Fluoroquinolone susceptibility testing was performed on invasive group A streptococcus isolates from 1992-1993 and 2003 from Ontario, Canada. None were nonsusceptible to levofloxacin. Two of 153 (1.3%) from 1992-1993 and 7 of 160 (4.4%) from 2003 had a levofloxacin MIC of 2 mug/ml; all nine had parC mutations, and eight were serotype M6.
authors.affiliation: Department of Microbiology, Toronto Medical Laboratories, Mount Sinai Hospital, 600 University Ave., Toronto, Ontario, Canada M5G 1X5.
authors.forename: Jeff
authors.initials: J
authors.lastname: Powis
authors.forename: Allison
authors.initials: A
authors.lastname: McGeer
authors.forename: Carla
authors.initials: C
authors.lastname: Duncan
authors.forename: Ryan
authors.initials: R
authors.lastname: Goren
authors.forename: Joyce C S
authors.initials: JC
authors.lastname: de Azavedo
authors.forename: Darrin J
authors.initials: DJ
authors.lastname: Bast
authors.forename: Sylvia
authors.initials: S
authors.lastname: Pong-Porter
authors.forename: Tony
authors.initials: T
authors.lastname: Mazzulli
authors.forename: Karen
authors.initials: K
authors.lastname: Green
authors.forename: Barbara
authors.initials: B
authors.lastname: Willey
authors.forename: Donald E
authors.initials: DE
authors.lastname: Low
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D027101:DNA Topoisomerase IV / Q000235:genetics; D024881:Drug Resistance, Bacterial; D024841:Fluoroquinolones / Q000494:pharmacology*; D006801:Humans; D009864:Ontario / Q000453:epidemiology; D011159:Population Surveillance; D013290:Streptococcal Infections / Q000453:epidemiology* / Q000382:microbiology*; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000235:genetics*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D027101:DNA Topoisomerase IV