title: Anti-HIV protease activity from rosa family plant extracts and rosamultin from Rosa rugosa.
abstract: To identify substances with anti-human immunodeficiency virus (HIV) activity from plant sources, 12 extracts of Rosa family plants were screened for their inhibitory effects against HIV-1 protease. Of the extracts tested, the strongest inhibitory effects were observed in the root of Rosa rugosa and the leaves of Prunus sargentii, at a concentration of 100 microg/mL. Rosamultin isolated from the root of R. rugosa inhibited HIV-1 protease by 53% at a concentration of 100 microM.
authors.affiliation: Department of Oriental Medicine Resources and Research Institute of Korean Oriental Medicine, Sunchon National University, Suncheon, Jeonnam, Republic of Korea. flavonoid@empal.com
authors.forename: Jong Cheol
authors.initials: JC
authors.lastname: Park
authors.forename: Sang Chul
authors.initials: SC
authors.lastname: Kim
authors.forename: Myeong Rak
authors.initials: MR
authors.lastname: Choi
authors.forename: Sang Ho
authors.initials: SH
authors.lastname: Song
authors.forename: Eun Jeong
authors.initials: EJ
authors.lastname: Yoo
authors.forename: Sung Hwan
authors.initials: SH
authors.lastname: Kim
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Miyashiro
authors.forename: Masao
authors.initials: M
authors.lastname: Hattori
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology / Q000627:therapeutic use; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D015658:HIV Infections / Q000188:drug therapy*; D016333:HIV Protease / Q000187:drug effects / Q000378:metabolism; D017320:HIV Protease Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D015497:HIV-1 / Q000201:enzymology / Q000235:genetics; D006801:Humans; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D027826:Rosa / Q000737:chemistry*; D016896:Treatment Outcome; D014315:Triterpenes / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D010936:Plant Extracts; D014315:Triterpenes; C051431:rosamultin; D016333:HIV Protease