title: Evaluation of risk factors for mortality in perforated peptic ulcer in Ankara Numune Teaching Hospital, Ankara, Turkey.
abstract: OBJECTIVE
  To assess the risk factor that influence mortality from perforated peptic ulcer.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Ankara Numune Teaching and Research Hospital, Ankara, Turkey.
  
  
  METHODS
  A total of 342 patients with perforated peptic ulcer disease were identified from April 1997 to January 2004. Data for the patients were extracted from the hospital records, operative notes and clinic charts.
  
  
  METHODS
  Age, sex, coexisting medical illness, use of non-steroidal anti-inflammatory drugs (NSAID) or steroids, preoperative shock, delay in treatment location of ulcer size, type of operation time, albumin concentration postoperative complications, postoperative hospitals stay and mortality results for all patients were obtained.
  
  
  RESULTS
  Patients were aged from 17 to 80 years (mean 63 years, median 68 years) there were 210 males and 132 females. The mortality rate was 8.8% (30/342), and 62 patients had postoperative complications. Multivariate analysis showed that co-existing medical illness, preoperative shock, delay in treatment and low albumin concentrations were independent risk factors that significantly contributed to mortality.
  
  
  CONCLUSIONS
  This study confirms co-existing medical illness, preoperative shock, delay in treatment and low albumin concentration as significant risk factors that increase mortality in patients with perforated peptic ulcers. These factors could serve as a guide to opine the risk and to improve the outcome in patients with perforated peptic ulcer. Mortality could be reduced by preventing delay in diagnosis and treatment for any co-existing medical illness and providing appropriate nutrition support.
authors.affiliation: Department of Surgery, Ankara Numune Teaching and Research Hospital, Ankara 06100, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Ozalp
authors.forename: B
authors.initials: B
authors.lastname: Zulfikaroglu
authors.forename: I
authors.initials: I
authors.lastname: Bilgic
authors.forename: M
authors.initials: M
authors.lastname: Koc
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D005260:Female; D006801:Humans; D007813:Laparotomy; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D010439:Peptic Ulcer Perforation / Q000175:diagnosis / Q000401:mortality* / Q000601:surgery; D011027:Pneumoperitoneum / Q000453:epidemiology; D011183:Postoperative Complications / Q000453:epidemiology; D011860:Radiography, Abdominal; D012086:Reoperation / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012307:Risk Factors; D017678:Sex Distribution; D012769:Shock / Q000453:epidemiology; D014421:Turkey / Q000453:epidemiology