title: Central nervous system tumors in donors: misdiagnosis carries a high morbidity and mortality.
abstract: BACKGROUND
  The cost of misdiagnosis of central nervous system (CNS) tumors in donors has not been previously described. The purpose of this study was to examine the Israel Penn International Transplant Tumor Registry experience with these donors.
  
  
  METHODS
  All cases where an error in diagnosis was made due to intracranial hemorrhage from undiagnosed CNS tumors and where CNS metastases were misdiagnosed as primary brain tumor were examined.
  
  
  RESULTS
  Forty-two organ recipients with misdiagnosed primary brain deaths from 29 donors were examined. After transplantation these donors were identified with: melanoma (23%), renal cell carcinoma (19%), choriocarcinoma (12%), sarcoma (10%), Kaposi's sarcoma (7%), and variable tumors (22%). The majority of patients were renal allograft recipients (84%) followed by liver (n = 4) and lung recipients (n = 1). The most commonly diagnostic error was with intracranial hemorrhage (ICH) (62%). A donor-related transmission rate of 74% (31/42) was identified among those patients with a misdiagnosed brain death. The majority of donor-transmitted cancers were identified in the recipient allograft (71%). Sixty-four percent of recipients suffered diffuse metastatic disease. Overall survival was poor, with a 5-year survival rate of 32% (10/31). Explantation was performed in 17 patients with confirmed donor-transmitted cancer, and in these patients a survival benefit was noted (10/17, 59%, vs 0/14, 0%; P < .01).
  
  
  CONCLUSIONS
  Error in the diagnosis of donor brain death due to CNS tumors has significant and often fatal consequences. Allograft explantation for kidney recipients or retransplantation for extrarenal recipients may provide a survival benefit. Potential donors with unclear etiologies for brain death, particularly ICH, should be considered for a limited brain autopsy after donation.
authors.affiliation: University of Cincinnati, Cincinnati, Ohio 45249, USA.
authors.forename: J F
authors.initials: JF
authors.lastname: Buell
authors.forename: T
authors.initials: T
authors.lastname: Gross
authors.forename: R R
authors.initials: RR
authors.lastname: Alloway
authors.forename: J
authors.initials: J
authors.lastname: Trofe
authors.forename: E S
authors.initials: ES
authors.lastname: Woodle
mesh_terms: D001926:Brain Death; D016543:Central Nervous System Neoplasms / Q000175:diagnosis*; D003951:Diagnostic Errors; D006801:Humans; D016030:Kidney Transplantation / Q000401:mortality* / Q000473:pathology*; D016031:Liver Transplantation / Q000401:mortality / Q000473:pathology; D016040:Lung Transplantation / Q000401:mortality / Q000473:pathology; D009369:Neoplasms / Q000401:mortality; D009820:Ohio; D011183:Postoperative Complications / Q000401:mortality; D012042:Registries; D012086:Reoperation; D016019:Survival Analysis; D014019:Tissue Donors