Levels of serum vitamin A, alpha-tocopherol and malondialdehyde in patients with non-alcoholic steatohepatitis: relationship with histopathologic severity.
The aims of our study were to estimate serum levels of malondialdehyde (MDA), serum levels of vitamin A and alpha-tocopherol as antioxidants and determine relationship of these with histopathologic severity in patients with non-alcoholic steatohepatitis (NASH). Twenty-nine patients with biopsy-proven NASH were included to study. NASH were histopathologically scored for grading and staging. Serum MDA and vitamin A levels were increased in patients with NASH and simple steatosis as compared to healthy control group. Serum alpha-tocopherol levels measured in simple steatosis and NASH were significantly lower than in healthy control group. There was no significant difference between grade/stage 0-1 and grade/stage 2-3 in terms of MDA, vitamin A and alpha-tocopherol levels. Serum MDA and vitamin A levels are increased in simple steatosis and NASH. MDA, vitamin A and alpha-tocopherol levels in NASH were not associated with the histopathologic severity.
Bahcecioglu
I H
IH
Division of Gastroenterology, Firat University, Elazig, Turkey.
Yalniz
M
M
Ilhan
N
N
Ataseven
H
H
Ozercan
I H
IH
D000328:Adult; D000368:Aged; D005235:Fatty Liver, Alcoholic / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D014801:Vitamin A / Q000097:blood*; D024502:alpha-Tocopherol / Q000097:blood*
D014801:Vitamin A; D008315:Malondialdehyde; D024502:alpha-Tocopherol