Vitamin K and sphingolipid metabolism: evidence to date.
The brain is enriched with sphingolipids, which are important membrane constituents and major lipid signaling molecules that have a role in motor and cognitive behavior. Vitamin K has been implicated in brain sphingolipid metabolism for more than 30 years. The in vitro and in vivo studies to date suggest a role of vitamin K in the regulation of multiple enzymes involved in sphingolipid metabolism within the myelin-rich regions in the brain. However, the precise mechanisms of action are not well understood. Further, the physiological consequences of the observed effects of vitamin K on sphingolipid metabolism have not been systematically studied.
Denisova
Natalia A
NA
Nutrition and Neurocognition Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA. natalia.denissova@tufts.edu
Booth
Sarah L
SL
D000818:Animals; D001921:Brain / Q000378:metabolism*; D006801:Humans; D013107:Sphingolipids / Q000737:chemistry / Q000378:metabolism*; D014812:Vitamin K / Q000502:physiology*
D013107:Sphingolipids; D014812:Vitamin K