title: Iron-catalyzed homo-coupling of simple and functionalized arylmagnesium reagents.
abstract: Iron-catalyzed homo-coupling of simple and functionalized arylmagnesium reagents is described. The reaction is highly chemoselective (CN, COOEt and NO(2) groups are tolerated). The procedure was used to perform intramolecular couplings. This cyclization reaction is the key step of the total synthesis of the N-methylcrinasiadine.
authors.affiliation: Laboratoire de Synthèse Organique Sélective et de Chimie Organométallique (SOSCO), UMR 8123 CNRS-UCP-ESCOM, Cergy-Pontoise, France. gerard.cahiez@chim-u.cergy.fr
authors.forename: Gérard
authors.initials: G
authors.lastname: Cahiez
authors.forename: Christophe
authors.initials: C
authors.lastname: Chaboche
authors.forename: Florence
authors.initials: F
authors.lastname: Mahuteau-Betzer
authors.forename: Mathieu
authors.initials: M
authors.lastname: Ahr
mesh_terms: D002384:Catalysis; D003500:Cyclization; D006576:Heterocyclic Compounds, 4 or More Rings / Q000032:analysis / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D007501:Iron / Q000737:chemistry*; D019668:Liliaceae / Q000737:chemistry; D008274:Magnesium / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D006576:Heterocyclic Compounds, 4 or More Rings; D007202:Indicators and Reagents; C507777:N-methylcrinasiadine; D007501:Iron; D008274:Magnesium