[Progress on the vaccine for anthrax].
Bacillus anthracis is the causative organism of the potentially fatal disease anthrax, and the used vaccines have some disadvantages. There are new developments appeared for the Bacillus anthracis in recent years, such as anti-PA antibody kills the spore of Bacillus anthracis, mucosal immunization induces immune responses in both systemic and secretory immune compartments, Poly (gamma-D-PGA) protein induce IgG antibodies to the vegetative bacteria, new pathogens were found by genomic analysis. The DNA vaccine and live vector vaccine will be the next generation vaccines for anthrax. It will have a shorter immunization schedule and will be greater protective efficacy than before.
Zhan
De-wen
DW
Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China. rmjl727@yahoo.com.cn
Wang
Peng
P
Wang
Ling-chun
LC
Zhang
Zhao-shan
ZS
D000881:Anthrax / Q000276:immunology* / Q000517:prevention & control; D022122:Anthrax Vaccines / Q000276:immunology*; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D001408:Bacillus anthracis / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D011099:Polyglutamic Acid / Q000276:immunology; D019444:Vaccines, DNA / Q000276:immunology
D022122:Anthrax Vaccines; D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D019444:Vaccines, DNA; D011099:Polyglutamic Acid