Wnt/frizzled signaling during vertebrate retinal development.
Multiple signaling pathways are known to be involved in regulating development of the vertebrate neural retina. Recent publications have demonstrated that Wnt/Frizzled (Fz) signaling components are expressed in the developing retina and may play a fundamental role in retinogenesis. In this review, we summarize Wnt/Fz expression patterns in the developing vertebrate retina, mainly from chick and mouse, and compare them with Wnt/beta-catenin reporter activity. Consistent with the dynamic expression patterns of Wnt pathway components, evidence suggests that Wnt/Fz signaling has multiple roles during retinal development.
Van Raay
Terence J
TJ
Department of Neurobiology and Anatomy, University of Utah, 20 North 1900 East, Salt Lake City, UT 84132, USA.
Vetter
Monica L
ML
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000378:metabolism; D051157:Frizzled Receptors; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled; D017981:Receptors, Neurotransmitter / Q000235:genetics / Q000378:metabolism*; D012160:Retina / Q000196:embryology* / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism; D014714:Vertebrates / Q000196:embryology* / Q000502:physiology; D051153:Wnt Proteins; D051176:beta Catenin
C495270:CTNNB1 protein, human; D003598:Cytoskeletal Proteins; D051157:Frizzled Receptors; C489739:Fzd1 protein, mouse; D036341:Intercellular Signaling Peptides and Proteins; D043562:Receptors, G-Protein-Coupled; D017981:Receptors, Neurotransmitter; D015534:Trans-Activators; D051153:Wnt Proteins; D051176:beta Catenin