A study to determine plasma antioxidant concentrations in patients with Barrett's oesophagus.
BACKGROUND
Dietary questionnaire studies have suggested that patients with oesophageal adenocarcinoma are deficient in antioxidants. It is not known whether the same holds true for patients with the precursor lesion, Barrett's oesophagus.


OBJECTIVE
To evaluate the hypothesis that patients with Barrett's oesophagus are deficient in antioxidants compared with patients without evidence of Barrett's oesophagus.


METHODS
Plasma antioxidant profiles (copper, selenium, zinc; vitamins A, C, and E; carotenoids) were determined for patients with Barrett's oesophagus (n = 36), patients with erosive oesophagitis (n = 32), and patient controls (n = 35).


RESULTS
Patients with Barrett's oesophagus had significantly lower plasma concentrations of selenium, vitamin C, beta cryptoxanthine, and xanthophyll compared with the other groups.


CONCLUSIONS
This study confirms the hypothesis that patients with Barrett's oesophagus are deficient in certain antioxidants.
Clements
D M
DM
Surgery Department, Royal Glamorgan Hospital, Llantrisant CF72 8XR, UK.
Oleesky
D A
DA
Smith
S C
SC
Wheatley
H
H
Hullin
D A
DA
Havard
T J
TJ
Bowrey
D J
DJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016588:Anticarcinogenic Agents / Q000097:blood; D000975:Antioxidants / Q000032:analysis*; D001205:Ascorbic Acid / Q000097:blood; D001471:Barrett Esophagus / Q000097:blood*; D002338:Carotenoids / Q000097:blood; D003300:Copper / Q000097:blood; D065366:Cryptoxanthins; D004941:Esophagitis / Q000097:blood; D005260:Female; D006801:Humans; D000077276:Lycopene; D008297:Male; D008875:Middle Aged; D012643:Selenium / Q000097:blood; D014801:Vitamin A / Q000097:blood; D014810:Vitamin E / Q000097:blood; D024341:Xanthophylls / Q000097:blood; D015032:Zinc / Q000097:blood; D019207:beta Carotene / Q000031:analogs & derivatives* / Q000097:blood
D016588:Anticarcinogenic Agents; D000975:Antioxidants; D065366:Cryptoxanthins; D024341:Xanthophylls; D019207:beta Carotene; D014801:Vitamin A; D014810:Vitamin E; D002338:Carotenoids; D003300:Copper; D012643:Selenium; D015032:Zinc; D001205:Ascorbic Acid; D000077276:Lycopene