Effects of iohexol on ventilatory functions in patients undergoing diagnostic coronary angiography.
OBJECTIVE
Adverse respiratory reactions have been reported with intravascular radiographic contrast media. The aim of the present study is to assess the effects of iohexol on pulmonary functions in patients undergoing diagnostic coronary angiography (CA).


METHODS
30 patients enrolled in the study. The respiratory functions of the patients were measured at three different stages during angiography (before, immediately after and 2 h later) and arterial blood gas analyses were performed at six stages during CA (before, immediately after the insertion of angiography catheter, 2 min after the injection of contrast agent, at the end of angiography, an hour and 2 h after angiography). A single, experienced angiographer performed the angiography procedures via radial artery route. Totally six multiple angled views of the left and right coronary arteries were recorded in all patients by hand injection. None of the patients were performed ventriculography.


RESULTS
Angiography caused significant reduction in forced expiratory volume in 1 sec [FEV1] (from 103 +/- 15 to 95 +/- 17, p < 0.01), forced vital capacity [FVC] (from 99 +/- 13 to 95 +/- 18, p < 0.05) and maximum mid-expiratory flow rate [MMF] (from 95 +/- 33 to 84 +/- 29, p < 0.01) whereas there were no significant changes in the mean FEV1/FVC ratios at different stages of angiography. Statistically significant decrease in PaO2 (from 91 +/- 10 to 85 +/- 13 mmHg, p < 0.01) and arterial O2 saturation (from 97 +/- 1% to 96 +/- 1%, p < 0.01) were also observed. Data in present study showed a clinically insignificant but statistically significant restrictive impairment in pulmonary functions.


CONCLUSIONS
Diagnostic CA using iohexol decreases ventilatory functions in a small but significant extent in patients without any overt pulmonary disease.
Ozhan
Hakan
H
Department of Cardiology, Abant Izzet Baysal University, Düzce Faculty of Medicine, Konuralp Düzee, Turkey.
Akdemir
Ramazan
R
Balbay
Oner
O
Arbak
Peri
P
Erbas
Mete
M
Gunduz
Huseyin
H
Yazici
Mehmet
M
Erbilen
Enver
E
Uyan
Cihangir
C
D002245:Carbon Dioxide / Q000097:blood; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects*; D017023:Coronary Angiography / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D007269:Injections, Intra-Arterial; D007472:Iohexol / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008450:Maximal Midexpiratory Flow Rate / Q000187:drug effects; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000187:drug effects; D012119:Respiration / Q000187:drug effects*; D014797:Vital Capacity / Q000187:drug effects
D003287:Contrast Media; D002245:Carbon Dioxide; D007472:Iohexol; D010100:Oxygen