title: The frequency of candidate alleles for CYP2D6 genotyping in the Japanese population with an additional respect to the -1584C to G substitution.
abstract: The -1584C/G single nucleotide polymorphism (SNP) in the promoter region of CYP2D6 was suggested to have the potential to influence CYP2D6 activity. In this report, we demonstrated the frequencies of -1584C to G substitution-related alleles, such as CYP2D6*2, CYP2D6*21, CYP2D6*35 and CYP2D6*41, in the Japanese population. The frequencies of CYP2D6*2, *41 and *21 were 0.102, 0.026 and 0.005, respectively. We also showed a relationship between the SNP and other common alleles, CYP2D6*4, *5, *10, *14 and *18. Interestingly, the SNP was detected in all three subjects carrying CYP2D6*14. This finding suggests the -1584G is included in the CYP2D6*14 allele, which is a null-allele characteristic to the Japanese population. This report presents practical information on CYP2D6 alleles that should be considered in the pharmacokinetic study of CYP2D6 substrates in the Japanese population.
authors.affiliation: Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Ikenaga
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Fukuda
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Fukuda
authors.forename: Yuko
authors.initials: Y
authors.lastname: Nishida
authors.forename: Masakazu
authors.initials: M
authors.lastname: Naohara
authors.forename: Hiromi
authors.initials: H
authors.lastname: Maune
authors.forename: Junichi
authors.initials: J
authors.lastname: Azuma
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution; D044466:Asian People; D003545:Cysteine / Q000235:genetics*; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D005838:Genotype; D005998:Glycine / Q000235:genetics*; D006801:Humans; D008297:Male
chemical_list: D019389:Cytochrome P-450 CYP2D6; D003545:Cysteine; D005998:Glycine