title: A simple procedure for measuring pharyngeal sensitivity: a contribution to the diagnosis of sleep apnoea.
abstract: BACKGROUND
  Patients with severe apnoea may have an impaired pharyngeal dilating reflex related to decreased pharyngeal sensitivity. The accuracy of a simple new procedure to measure pharyngeal sensitivity and to diagnose sleep disordered breathing (SDB) was investigated.
  
  
  METHODS
  Pharyngeal disappearance and appearance sensory perception thresholds were measured by delivering different airflow rates on the soft palate using an intraoral device in 17 controls and 50 patients suffering from SDB evaluated by overnight polygraphy. The procedure was performed before (baseline) and after three successive administrations of a topical anaesthetic to sensitise the pharyngeal sensory impairment. Pharyngeal sensitivity was then evaluated according to SDB severity. SDB was classified as mild, moderate or severe according to the relative proportion of obstructive apnoeas-hypopnoeas and the amount of desaturation.
  
  
  RESULTS
  Patients had higher baseline disappearance and appearance sensory thresholds than controls (mean (SD) 0.62 (0.44) v 0.26 (0.06) l/min and 0.85 (0.40) v 0.40 (0.19) l/min, p<0.001, respectively). Such differences were enhanced by topical anaesthesia. Impairment of pharyngeal sensitivity and the number of patients with impaired sensitivity increased from the least to the most severe SDB group as indicated by the test sensitivity for a respiratory disturbance index of >20/hour (50%, 73.7% and 88.5% in the mild, moderate, and severely affected groups, respectively).
  
  
  CONCLUSIONS
  This simple and safe procedure showed that impairment of pharyngeal sensitivity is correlated with severity of SDB. Using this test in routine clinical practice may simplify the diagnosis of sleep apnoea, particularly for the most severe patients.
authors.affiliation: Laboratoire HP2 (INSERM ESPRI EA3745), Centre Hospitalier Universitaire, Grenoble Cedex, France. maurice.dematteis@ujf-grenoble.fr
authors.forename: M
authors.initials: M
authors.lastname: Dematteis
authors.forename: P
authors.initials: P
authors.lastname: Lévy
authors.forename: J-L
authors.initials: JL
authors.lastname: Pépin
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D006801:Humans; D008297:Male; D008875:Middle Aged; D010614:Pharynx / Q000502:physiology*; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012684:Sensory Thresholds; D012891:Sleep Apnea Syndromes / Q000175:diagnosis*