A new method for the synthesis of acyltitanium complexes and their application to copper-mediated acylmetallation of carbon-carbon multiple bonds in aqueous media.
Treatment of alpha, beta-unsaturated carbonyl compounds or methyl propargyl ether with acylchlorobis(cyclopentadienyl)titanium in the presence of triethylamine and a copper salt in aqueous THF resulted in acylation of the carbon-carbon multiple bond, yielding the corresponding 1,4-diketones in good yields.
Han
Zhenfu
Z
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto-daigaku Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan.
Fujioka
Takuma
T
Usugi
Shin-Ichi
S
Yorimitsu
Hideki
H
Shinokubo
Hiroshi
H
Oshima
Koichiro
K