title: Obesity and metabolic syndrome in circadian Clock mutant mice.
abstract: The CLOCK transcription factor is a key component of the molecular circadian clock within pacemaker neurons of the hypothalamic suprachiasmatic nucleus. We found that homozygous Clock mutant mice have a greatly attenuated diurnal feeding rhythm, are hyperphagic and obese, and develop a metabolic syndrome of hyperleptinemia, hyperlipidemia, hepatic steatosis, hyperglycemia, and hypoinsulinemia. Expression of transcripts encoding selected hypothalamic peptides associated with energy balance was attenuated in the Clock mutant mice. These results suggest that the circadian clock gene network plays an important role in mammalian energy balance.
authors.affiliation: Department of Neurology, Northwestern University, Evanston, IL 60208, USA.
authors.forename: Fred W
authors.initials: FW
authors.lastname: Turek
authors.forename: Corinne
authors.initials: C
authors.lastname: Joshu
authors.forename: Akira
authors.initials: A
authors.lastname: Kohsaka
authors.forename: Emily
authors.initials: E
authors.lastname: Lin
authors.forename: Ganka
authors.initials: G
authors.lastname: Ivanova
authors.forename: Erin
authors.initials: E
authors.lastname: McDearmon
authors.forename: Aaron
authors.initials: A
authors.lastname: Laposky
authors.forename: Sue
authors.initials: S
authors.lastname: Losee-Olson
authors.forename: Amy
authors.initials: A
authors.lastname: Easton
authors.forename: Dalan R
authors.initials: DR
authors.lastname: Jensen
authors.forename: Robert H
authors.initials: RH
authors.lastname: Eckel
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Takahashi
authors.forename: Joseph
authors.initials: J
authors.lastname: Bass
mesh_terms: D017667:Adipocytes / Q000473:pathology; D000818:Animals; D001835:Body Weight; D001921:Brain / Q000378:metabolism; D056926:CLOCK Proteins; D002940:Circadian Rhythm; D004041:Dietary Fats / Q000008:administration & dosage; D002149:Energy Intake; D004734:Energy Metabolism; D005247:Feeding Behavior; D022781:Hepatocytes / Q000473:pathology; D006943:Hyperglycemia; D006949:Hyperlipidemias; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D024821:Metabolic Syndrome / Q000235:genetics / Q000503:physiopathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity; D009154:Mutation; D009479:Neuropeptides / Q000235:genetics / Q000378:metabolism; D009765:Obesity / Q000235:genetics / Q000503:physiopathology*; D015534:Trans-Activators / Q000235:genetics* / Q000502:physiology*; D015430:Weight Gain
chemical_list: D004041:Dietary Fats; D007328:Insulin; D020738:Leptin; D009479:Neuropeptides; D015534:Trans-Activators; D056926:CLOCK Proteins; C538944:Clock protein, mouse