Levels of anti-A/B antibodies after ABO-incompatible hematopoietic stem cell transplantation.
In contrast to solid organ transplantation, ABO incompatibility is generally not associated with survival differences in hematopoietic stem cell transplantation. Therefore, patients receiving ABO-incompatible stem cell transplantation can be analyzed to study the mechanism of tolerance induction after antigen-mismatched transplantation. The goal of this study was to analyze the levels of anti-A/B antibodies after ABO-incompatible transplantation. Host-derived antidonor antibodies disappeared rapidly after transplantation and did not reappear in the further posttransplant course. Donor-derived antihost antibodies did not significantly increase and compatible anti-A/B antibodies remained positive after hematopoietic stem cell transplantation. Thus, there is no evidence for stimulation of donor B lymphocytes to produce antirecipient antibodies suggesting a potential B cell tolerance.
Stussi
G
G
Laboratory for Transplantation Immunology, University Hospital of Zürich, Switzerland.
Huggel
K
K
Schanz
U
U
Passweg
J R
JR
Seebach
J D
JD
D000017:ABO Blood-Group System / Q000276:immunology*; D000741:Anemia, Aplastic / Q000276:immunology / Q000628:therapy; D001787:Blood Group Incompatibility / Q000209:etiology / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D006087:Graft vs Host Reaction / Q000276:immunology; D019337:Hematologic Neoplasms / Q000276:immunology / Q000628:therapy; D006789:Host vs Graft Reaction / Q000276:immunology; D006801:Humans; D033581:Stem Cell Transplantation / Q000009:adverse effects*
D000017:ABO Blood-Group System