[Optic neuritis associated with infliximab].
Infliximab is a chimeric human-murine monoclonal antibody of the IgG1 type with a high affinity and specificity for tumor necrosis factor alpha (TNFalpha). Infliximab was used in Crohn disease, rheumatoid arthritis, spondyloarthropathy, juvenile idiopathic arthritis, Behcet's disease, Wegener's granulomatosis, HLA-B27-associated uveitis and chronic severe refractory uveitis. Reported adverse effects of this treatment were infections, development of antinuclear antibodies and anti double-stranded DNA, lymphomas, and exacerbation of demyelinating disease. We report a case of infliximab-associated optic neuritis with favorable outcome after systemic steroid treatment.
Tran
T H C
TH
Service d'Ophtalmologie, 75013 Paris, France.
Milea
D
D
Cassoux
N
N
Bodaghi
B
B
Bourgeois
P
P
LeHoang
P
P
D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D018501:Antirheumatic Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D000069285:Infliximab; D008875:Middle Aged; D009902:Optic Neuritis / Q000139:chemically induced*
D000911:Antibodies, Monoclonal; D018501:Antirheumatic Agents; D000069285:Infliximab