The importance of microbiological investigations, medications and artificial feeding in diarrhoea evaluation.
BACKGROUND
Diarrhoea in hospitalised patients is usually attributed to medications especially antibiotics, enteral tube feeding or enteropathogenic bacteria particularly Clostridium difficile.


OBJECTIVE
The aim of this study was to evaluate the investigations performed on patients who developed diarrhoea during their stay in an acute general hospital.


METHODS
Over 18 working days, an unselected group of adult inpatients who developed diarrhoea following their admission to hospital were reviewed. Symptoms, medications, nutritional support and any investigations performed were assessed.


RESULTS
Eighty-one patients developed diarrhoea. Forty-nine (60%) were receiving antibiotics prior to the development of symptoms, 30 (37%) were being enterally tube fed, 14 (17%) had positive stool for Clostridium difficile A and B toxin and 3 (4%) had salmonella species positive stool.


CONCLUSIONS
The majority of cases of diarrhoea were related to medications and enteral tube feeding. A small but significant number did develop bacterial infections. In contrast to some suggested guidelines, when investigating hospital acquired diarrhoea, it is considered worthwhile to perform microbiological stool examinations.
McErlean
A
A
Department of Clinical Pharmacology/Gastroenterology, Beaumont Hospital and Royal College of Surgeons in Ireland, Dublin 9, Ireland. aoifemcerlean@eircom.net
Kelly
O
O
Bergin
S
S
Patchett
S E
SE
Murray
F E
FE
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D016360:Clostridioides difficile / Q000302:isolation & purification*; D003015:Clostridium Infections / Q000175:diagnosis / Q000382:microbiology; D003428:Cross Infection / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology; D003967:Diarrhea / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology; D064420:Drug-Related Side Effects and Adverse Reactions; D004750:Enteral Nutrition / Q000009:adverse effects*; D005260:Female; D006769:Hospitals, General; D006784:Hospitals, Teaching; D006801:Humans; D007494:Ireland / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D012475:Salmonella / Q000302:isolation & purification
D000900:Anti-Bacterial Agents