title: Cochlin deposits in the trabecular meshwork of the glaucomatous DBA/2J mouse.
abstract: Cochlin deposits were observed in the trabecular meshwork (TM) of 8-month-old glaucomatous DBA/2J mice, coincident with the reported onset of increased intraocular pressure and optic nerve damage. An age-dependent increase in cochlin was observed up to 10 months of age and was paralleled by a decrease in type II collagen. Similar expression patterns exist in the TM of humans with primary open-angle glaucoma. Cochlin deposits, absent in non-glaucomatous mouse and human TM, may disrupt the TM extracellular matrix and obstruct aqueous humor circulation. Studies of DBA/2J mice offer promise for understanding the role cochlin may play in glaucoma.
authors.forename: Sanjoy K
authors.initials: SK
authors.lastname: Bhattacharya
authors.forename: Suresh P
authors.initials: SP
authors.lastname: Annangudi
authors.forename: Robert G
authors.initials: RG
authors.lastname: Salomon
authors.forename: Rachel W
authors.initials: RW
authors.lastname: Kuchtey
authors.forename: Neal S
authors.initials: NS
authors.lastname: Peachey
authors.forename: John W
authors.initials: JW
authors.lastname: Crabb
mesh_terms: D000375:Aging; D000818:Animals; D003094:Collagen / Q000378:metabolism; D016326:Extracellular Matrix Proteins; D005902:Glaucoma, Open-Angle / Q000378:metabolism*; D051379:Mice; D008811:Mice, Inbred DBA; D023421:Models, Animal; D011506:Proteins / Q000378:metabolism*; D014129:Trabecular Meshwork / Q000378:metabolism*
chemical_list: C491729:Coch protein, mouse; D016326:Extracellular Matrix Proteins; D011506:Proteins; D003094:Collagen