Tissue specific and variable collagen proliferation in Swiss albino mice treated with clenbuterol.
Chronic administration of clenbuterol, a beta-adrenoceptor agonist (2 mg/kg body weight/day for 30 days) to mice resulted in an increased body mass. Measurement of dry tissue mass suggested a protein anabolic effect in the gastrocnemius and heart. Quantitative estimation of collagen content, a non-contractile element as calculated from hydroxyproline assay revealed its proliferation in the gastrocnemius, cardiac ventricle, intestine and to some extent also in the kidney. Clenbuterol did not induce collagen proliferation in non-muscle tissues such as the lungs and liver. Histopathological examination of sections from treated ventricles showed an extensive collagen infiltration in the subendocardium and at myonecrosis sites.
Patiyal
S N
SN
Department of Biosciences, Himachal Pradesh University, Summer Hill, Shimla-171 005, India. snpatiyal@yahoo.co.in
Katoch
S S
SS
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002078:Butoxamine / Q000494:pharmacology; D002976:Clenbuterol / Q000494:pharmacology*; D003094:Collagen / Q000378:metabolism*; D006352:Heart Ventricles / Q000187:drug effects; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects; D008297:Male; D051379:Mice; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D002078:Butoxamine; D003094:Collagen; D002976:Clenbuterol