title: [The expression of p73 and c-fos protein in hemangioma and its significance].
abstract: OBJECTIVE
  To investigate the expression of p73 and c-fos protein and its significance in the development of children hemangioma.
  
  
  METHODS
  The quantitative expressions of p73 and c-fos protein in hemangioma and normal skin were detected by immunohistochemistry.
  
  
  RESULTS
  The expressions of p73 and c-fos protein were strong in proliferative hemangioma while they were very weak in involutional hemangioma and normal skin. There were significant differences between the proliferative and involutional hemangioma or the normal skin in the expressions of p73 and c-fos (P < 0.01). No statistical significances of p73 or c-fos P73 expressions were observed between involutional hemangioma and normal skin (P > 0.05).
  
  
  CONCLUSIONS
  P73 and c-fos may play an important role in the development and involution of skin hemangioma.
authors.affiliation: The Department of Geriatrics, the People' s Hospital of Wuhan University, Wuhan 430060, China.
authors.forename: Zhi-xiong
authors.initials: ZX
authors.lastname: Chen
authors.forename: Sheng-guo
authors.initials: SG
authors.lastname: Shan
authors.forename: Duan-lian
authors.initials: DL
authors.lastname: Zhang
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
authors.forename: Yong
authors.initials: Y
authors.lastname: Yang
mesh_terms: D002648:Child; D002675:Child, Preschool; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005260:Female; D006391:Hemangioma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D016760:Proto-Oncogene Proteins c-fos; C000606460:TP73 protein, human; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins