Direct one-pot conversion of acylated carbohydrates into their alkylated derivatives under heterogeneous reaction conditions using solid NaOH and a phase transfer catalyst.
A convenient one-pot protocol for the direct conversion of acyl-protected carbohydrates into their alkylated counterparts has been developed by using alkyl halides in the presence of solid sodium hydroxide and a phase transfer catalyst. These economically convenient, mild, two-phase reaction conditions allow the preparation of a variety of monosaccharide intermediates for use in the synthesis of complex oligosaccharides.
Madhusudan
Soni Kamlesh
SK
Medicinal and Process Chemistry Division, Central Drug Research Institute (CDRI), Chattar Manzil Palace, Lucknow 226 001, UP, India.
Agnihotri
Geetanjali
G
Negi
Devendra S
DS
Misra
Anup Kumar
AK
D000107:Acetylation; D000478:Alkylation; D002241:Carbohydrates / Q000737:chemistry*; D012972:Sodium Hydroxide / Q000737:chemistry*
D002241:Carbohydrates; D012972:Sodium Hydroxide