A novel WISp39 protein links Hsp90 and p21 stability to the G2/M checkpoint.
Transcriptional regulation of the p21(Cip1) cyclin-dependent kinase inhibitor is a well-established mechanism by which the cell orchestrates a proper spatial and temporal cell cycle progression. Now, in the January 2005 issue of Molecular Cell (2005; Vol 17, 237-49), a study by Jascur et al identifies a novel multi-protein complex that is critical in contributing to a p53-dependent G2 cell cycle checkpoint. The authors demonstrate the significance of stabilizing the p21 protein in the context of this complex.
Benzeno
Sharon
S
The Leonard and Madlyn Abramson Family Cancer Research Institute and Cancer Center, Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Diehl
J Alan
JA
D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000378:metabolism / Q000502:physiology*; D016195:G2 Phase; D018841:HSP90 Heat-Shock Proteins / Q000378:metabolism / Q000502:physiology*; D020104:Immunophilins; D008938:Mitosis; D008954:Models, Biological; D022021:Tacrolimus Binding Proteins
D018797:Cell Cycle Proteins; D050759:Cyclin-Dependent Kinase Inhibitor p21; C400101:FKBPL protein, human; D018841:HSP90 Heat-Shock Proteins; D022021:Tacrolimus Binding Proteins; D020104:Immunophilins