title: Corneal pseudomembrane from acute inflammatory response and fibrin formation to acute myeloid leukemic infiltrate.
abstract: OBJECTIVE
  To describe an unusual ocular manifestation of a patient with acute myeloid leukemia (AML).
  
  
  METHODS
  Observational case report.
  
  
  METHODS
  A 59-year-old woman with a history of preleukemic myelodysplastic syndrome (MDS) and status post bone marrow transplant (BMT) complained of a sudden onset of poor vision associated with a corneal pseudomembrane. Ocular graft vs host disease was suspected, and the pseudomembrane was excised for histopathologic examination.
  
  
  RESULTS
  The pseudomembrane showed myeloblasts admixed with an acute inflammatory response suggestive of the development of AML, a complication of MDS. Bone marrow examination confirmed the diagnosis of relapsing AML.
  
  
  CONCLUSIONS
  Acute myeloid leukemia could present as a pseudomembrane; thus, examination of relevant ocular tissue is recommended.
authors.affiliation: National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA. kurups@nei.nih.gov
authors.forename: Shree K
authors.initials: SK
authors.lastname: Kurup
authors.forename: Hanna
authors.initials: H
authors.lastname: Coleman
authors.forename: Chi-Chao
authors.initials: CC
authors.lastname: Chan
mesh_terms: D000208:Acute Disease; D001853:Bone Marrow / Q000473:pathology; D016026:Bone Marrow Transplantation; D003316:Corneal Diseases / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D005260:Female; D005337:Fibrin / Q000378:metabolism*; D006086:Graft vs Host Disease / Q000209:etiology* / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications* / Q000473:pathology / Q000628:therapy; D008566:Membranes; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local
chemical_list: D005337:Fibrin