Development of squamous cell carcinoma of the tongue during induction chemotherapy for acute myeloid leukemia.
Immunosuppression is a well-recognized cause of skin tumors, in particular squamous cell carcinomas (SCC). In patients with hematological malignancies undergoing chemotherapy, SCC has been reported late in the course of the disease or many years after completion of treatment. Here we report a patient with acute myeloid leukemia who developed a SCC of the tongue while receiving the third course of induction chemotherapy. This is the second such case in the medical literature. The role of immunosuppression, chemotherapy, the malignancy itself and possible genetic predisposition is discussed and the literature on this topic is reviewed.
Ural
Ali Ugur
AU
Department of Hematology, School of Medicine, Gulhane Military Medical Academy, 06010 Etlik, Ankara, Turkey. aural@gata.edu.tr
Avcu
Ferit
F
Yilmaz
Mahmut Ilker
MI
Guden
Metin
M
Ozturk
Bekir
B
Ozcan
Ayhan
A
Guran
Sefik
S
Bahce
Muhterem
M
Yalcin
Atilla
A
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000276:immunology; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D016609:Neoplasms, Second Primary / Q000139:chemically induced* / Q000276:immunology; D012074:Remission Induction; D014062:Tongue Neoplasms / Q000139:chemically induced* / Q000276:immunology