[The expressions of survivin in squamous cell carcinoma of larynx and its clinical significance].
OBJECTIVE
To investigate the expressions of Survivin in squamous cell carcinoma of larynx (SCCL) and the correlation between Survivin and survival time.


METHODS
The expressions of Survivin in SCCL tissues of 40 cases and normal larynx tissues of 5 cases were studied by immunohistochemical staining and quantitative analysis of image.


RESULTS
The expressions of Survivin in SCCL tissues were higher than those in mucosa of controls (P < 0.01). The expressions of Survivin in SCCL with the metastasis of lymph nodes were higher than those without metastasis( P < 0.05). Age and sex did not change the expressions obviously( P > 0.05). The expressions of Survivin in SCCL have a positive correlation between T-stages( P < 0.05). There was also a negative correlation in staining intensity between Survivin and survival time ( r = -0.646, P < 0.01).


CONCLUSIONS
A significant correlation between Survivin expression and T-stage( P < 0.05), lymph node metastasis( P < 0.05) and prognosis (P < 0.01) was revealed in squamous cell carcinoma of larynx. The high expression suggests worse prognosis. The up-regulate of Survivin suggests that it play an important role in the formation and metastasis of SCCL.
Wang
Yanjun
Y
Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Kong
Weijia
W
Sun
Dawei
D
Chen
Xiong
X
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000556:secondary; D005260:Female; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008869:Microtubule-Associated Proteins / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D011379:Prognosis; D015996:Survival Rate; D000077022:Survivin
C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D000077022:Survivin