title: Baseline glomerular sclerosis influences morphological changes, but not level of serum creatinine.
abstract: The aim of this study was to investigate whether glomerular sclerosis (GS) at the time of engraftment affects subsequent morphology and clinical course of renal allografts. Eighty-one renal transplant recipients were recruited for this study. Protocol biopsies of the renal allografts were performed at engraftment, as well as at 1, 3, 5, and 7 years after transplantation. All cases were divided into 2 groups based on the presence of GS at engraftment, namely, non-GS and GS groups. Morphological changes in the renal allografts were graded from 0 to 3+ based on the severity of chronic allograft nephropathy (CAN) of the Banff classification based on 5 factors: percentage of GS, extent of interstitial fibrosis, tubular atrophy, arterial intimal thickening, and arteriolar hyalinosis. Furthermore, the level of serum creatinine (s-Cr) at each year was examined by recipient age and gender, donor age and gender, type of donor (living/cadaver), delayed graft function, acute rejection within 1 year after transplantation, mean blood pressure, and use of calcineurin inhibitors as well as the presence of GS at engraftment. The extent of GS at engraftment significantly correlated with donor age (P = .0038) but with a weak correlation coefficient. Although the severity of CAN developed gradually in both non-GS and GS groups, differences in morphological changes at engraftment between the 2 groups persisted throughout 7 years. Donor age and recipient gender influenced s-Cr significantly. In conclusion, the presence of GS at engraftment aggravates subsequent morphological changes and affects short-term but not long-term allograft prognosis.
authors.affiliation: Department of Nephrology, Toho University School of Medicine, Tokyo, Japan. masaki7419@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Muramatsu
authors.forename: M
authors.initials: M
authors.lastname: Miyagi
authors.forename: Y
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Itabashi
authors.forename: T
authors.initials: T
authors.lastname: Kawamura
authors.forename: K
authors.initials: K
authors.lastname: Arai
authors.forename: K
authors.initials: K
authors.lastname: Sakai
authors.forename: A
authors.initials: A
authors.lastname: Aikawa
authors.forename: S
authors.initials: S
authors.lastname: Mizuiri
authors.forename: T
authors.initials: T
authors.lastname: Ohara
authors.forename: A
authors.initials: A
authors.lastname: Hasegawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D003404:Creatinine / Q000097:blood*; D005500:Follow-Up Studies; D005923:Glomerulosclerosis, Focal Segmental / Q000097:blood* / Q000473:pathology*; D006801:Humans; D016030:Kidney Transplantation / Q000473:pathology* / Q000502:physiology*; D008875:Middle Aged; D011183:Postoperative Complications / Q000473:pathology; D012044:Regression Analysis; D013997:Time Factors; D014184:Transplantation, Homologous / Q000473:pathology / Q000502:physiology
chemical_list: D003404:Creatinine