Production of heptaene antifungal antibiotic by Streptomyces purpeofuscus CM 1261.
A strain of Streptomyces purpeofuscus CM 1261 isolated from a sample of compost collected locally was found to possess strong antagonistic activity against 4 human pathogenic fungi i.e., Candida albicans, Aspergillus niger, Microsporum gypseum and Trichophyton sp. The active antifungal compound produced by it was found to be a heptaene group of polyene antifungal antibiotic.
Jain
Praveen Kumar
PK
Department of Applied Microbiology and Biotechnology, Dr H S Gour Vishwavidyalaya, Sagar, India.
Jain
P C
PC
D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects; D003904:Mitosporic Fungi / Q000187:drug effects*; D011090:Polyenes; D013302:Streptomyces / Q000378:metabolism*; D014249:Trichophyton / Q000187:drug effects
D000935:Antifungal Agents; D011090:Polyenes