NOS:molecular mechanisms, clinical aspects, therapeutic and monitoring approaches.
Nitrosative stress and nitration of proteins in airway epithelium maybe responsible for steroid resistance in asthma and steroid ineffectiveness in chronic obstructive pulmonary disease (COPD), supporting the potential role of future therapeutic strategies aimed at regulating NO synthesis in asthma and COPD (for example, combination treatment with NOS inhibitors and corticosteroids). Here, the potential role of NO modulators (NO synthase inhibitors and NO donors) has been reviewed, which if are given on a regular basis may have clinical benefit in asthma and COPD.
Kharitonov
Sergei A
SA
Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, Royal Brompton and Harefield NHS Trust, London SW3 6LY, UK. s.kharitonov@imperial.ac.uk
D000402:Airway Obstruction / Q000188:drug therapy / Q000503:physiopathology; D000818:Animals; D016903:Drug Monitoring; D006801:Humans; D009569:Nitric Oxide / Q000502:physiology*; D020030:Nitric Oxide Donors / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000502:physiology*; D012140:Respiratory Tract Diseases / Q000188:drug therapy / Q000503:physiopathology*; D013312:Stress, Physiological / Q000175:diagnosis / Q000503:physiopathology
D020030:Nitric Oxide Donors; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase