Synthesis of a methylene analog of 5-amino-1-beta-D-ribofuranosylimidazole-4-carboxamide monophosphate (ZMP).
A novel ZMP analog 3 was synthesized from inosine in 10 steps, and exhibited small but significant inhibitory activity toward protein kinase C.
Kohyama
Naoki
N
Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606-8501, Japan.
Hayashi
Tatsuya
T
Yamamoto
Yukio
Y
D000620:Aminoimidazole Carboxamide / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D006838:Hydrocarbons; D009682:Magnetic Resonance Spectroscopy; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D012265:Ribonucleotides / Q000138:chemical synthesis / Q000737:chemistry*
D006838:Hydrocarbons; D012265:Ribonucleotides; C030011:carbene; D000620:Aminoimidazole Carboxamide; C031143:AICA ribonucleotide; D008697:Methane