Beneficial effects of vitamin C and vitamin E on reserpine-induced oral dyskinesia in rats: critical role of striatal catalase activity.
Oral dyskinesias are implicated in a series of neuropathologies and have been associated to an increase in oxidative stress. Several antioxidants, including vitamin E, decrease reserpine-induced oral dyskinesia (OD) in rodents and we have described a protective role of striatal catalase against the development of OD. The aim of this study was to verify the effects of vitamin C alone or in combination with vitamin E on reserpine-induced OD as well as to determine a possible role of catalase in the antidyskinetic property of these vitamins. Different doses of vitamin C attenuated reserpine-induced increase in OD. A similar treatment with an effective dose of vitamin C concomitant to an effective dose of vitamin E potentiated the antidyskinetic effect of both vitamins when administered alone. The administration of these vitamins alone produced an increase in striatal catalase activity that likewise was potentiated by their combined administration. In addition, the antidyskinetic property of vitamin E and vitamin C was abolished by a concomitant treatment with the catalase inhibitor aminotriazole. These results indicate a beneficial effect of these vitamins and reinforce the critical role of striatal catalase against the development of oral dyskinesias.
Faria
Rulian Ricardo
RR
Department of Pharmacology, Escola Paulista de Medicina/UNIFESP, São Paulo, Brazil.
Abílio
Vanessa Costhek
VC
Grassl
Christian
C
Chinen
Cibele Cristina
CC
Negrão
Luciana Takahashi Ribeiro
LT
de Castro
Juliana Pedroso Moraes Vilela
JP
Fukushiro
Daniela Fukue
DF
Rodrigues
Marcelo Scarpari Dutra
MS
Gomes
Patricia Helena Zanier
PH
Registro
Sibele
S
de Carvalho
Rita de Cassia
Rde C
D'Almeida
Vania
V
Silva
Regina Helena
RH
Ribeiro
Rosana de Alencar
Rde A
Frussa-Filho
Roberto
R
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D002374:Catalase / Q000378:metabolism*; D003342:Corpus Striatum / Q000187:drug effects / Q000201:enzymology*; D004409:Dyskinesia, Drug-Induced / Q000201:enzymology* / Q000517:prevention & control*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012110:Reserpine / Q000633:toxicity; D014810:Vitamin E / Q000494:pharmacology / Q000627:therapeutic use*
D014810:Vitamin E; D012110:Reserpine; D002374:Catalase; D001205:Ascorbic Acid