title: Calbistrin E and two other new metabolites from an Australian isolate of Penicillium striatisporum.
abstract: An Australian isolate of Penicillium striatisporum collected near Shalvey, New South Wales, exhibited selective antifungal activity against Candida albicans versus Saccharomyces cerevisiae. Bioassay-directed fractionation yielded members of the rare class of fungal metabolites known as the calbistrins. These included a new example of this structure class, calbistrin E (1), as well as the known polyenes calbistrin C (2) and deformylcalbistrin A (3). Also recovered from P. striatisporum were new triene and butenolide acids, striatisporin A (4) and striatisporolide A (5), together with the known fungal metabolites versiol (6) and (+)-hexylitaconic acid (7). Structures for all metabolites were determined by detailed spectroscopic analysis.
authors.affiliation: Centre for Molecular Biodiversity, Institute for Molecular Bioscience, University of Queensland, St. Lucia, Queensland 4072, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Stewart
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Capon
authors.forename: Ernest
authors.initials: E
authors.lastname: Lacey
authors.forename: Shaun
authors.initials: S
authors.lastname: Tennant
authors.forename: Jennifer H
authors.initials: JH
authors.lastname: Gill
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001315:Australia; D002176:Candida albicans / Q000187:drug effects; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009517:New South Wales; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013386:Succinates / Q000737:chemistry
chemical_list: C426868:2-methylene-3-hexylbutanedioic acid; D000935:Antifungal Agents; D006575:Heterocyclic Compounds, 3-Ring; D009281:Naphthalenes; D013386:Succinates; C501037:calbistrin E; C470969:versiol