title: Neurobiology of anorexia nervosa: clinical implications of alterations of the function of serotonin and other neuronal systems.
abstract: Recent evidence suggests that genetic and neurobiologically mediated mechanisms contribute to the etiology of anorexia nervosa (AN). Serotonin neuronal systems, in particular, may create vulnerabilities related to pathological feeding, anxiety and obsessions, and extremes of impulse control, that make individuals susceptible to developing an eating disorder, perhaps in combination with environmental stressors.
authors.affiliation: Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.
authors.forename: Walter H
authors.initials: WH
authors.lastname: Kaye
authors.forename: Guido K
authors.initials: GK
authors.lastname: Frank
authors.forename: Ursula F
authors.initials: UF
authors.lastname: Bailer
authors.forename: Shannan E
authors.initials: SE
authors.lastname: Henry
mesh_terms: D000367:Age Factors; D000856:Anorexia Nervosa / Q000453:epidemiology / Q000378:metabolism*; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001007:Anxiety / Q000188:drug therapy / Q000453:epidemiology; D001828:Body Image; D001921:Brain / Q000378:metabolism*; D001933:Brain Stem / Q000378:metabolism; D003071:Cognition; D003342:Corpus Striatum / Q000378:metabolism; D003717:Denial, Psychological; D004777:Environment; D006801:Humans; D008016:Life Change Events; D008032:Limbic System / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D011903:Raphe Nuclei / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D012737:Sex Factors; D013001:Somatoform Disorders / Q000453:epidemiology
chemical_list: D014150:Antipsychotic Agents; D012701:Serotonin