The relationship between chemical structure and antimicrobial activity of selected nicotinates, p-iodobenzoates, picolinates and isonicotinates.
Alkaline metal, calcium and magnesium p-iodobenzoates and alkaline metal nicotinates, as well as sodium and potassium picolinic and isonicotinates were investigated by means of their antimicrobial and chemical properties. The quality estimation of the influence of metal cation coordinated to the carboxylic anion of the series of studied compounds on their antimicrobial activity as well as on the vibrational structure of whole complex in water solution was done. The changes in antimicrobial properties and in charge distribution of the complex along the position of nitrogen atom in the aromatic ring in sodium and potassium complexes were investigated. The analysis of influence of iodine substituent in para position on the change of electronic charge distribution of carboxylate anion and aromatic ring was done. The relationship between electronic properties estimated by vibrational spectroscopy and antimicrobial activity of studied complexes was investigated.
Koczoń
P
P
Department of Chemistry, Warsaw Agricultural University, ul. Nowoursynowska 161C, 02728 Warsaw, Poland. koczon@delta.sggw.waw.pl
Piekut
J
J
Borawska
M
M
Swisłocka
R
R
Lewandowski
W
W
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000378:metabolism; D001565:Benzoates / Q000737:chemistry* / Q000494:pharmacology; D004926:Escherichia coli / Q000378:metabolism; D005520:Food Preservatives / Q000494:pharmacology; D007455:Iodine / Q000737:chemistry; D007463:Iodobenzoates / Q000737:chemistry* / Q000494:pharmacology; D007539:Isonicotinic Acids / Q000737:chemistry* / Q000494:pharmacology; D008670:Metals / Q000737:chemistry; D008956:Models, Chemical; D008968:Molecular Conformation; D009525:Niacin / Q000737:chemistry* / Q000494:pharmacology; D010843:Pichia / Q000378:metabolism; D010848:Picolinic Acids / Q000737:chemistry* / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D013053:Spectrophotometry; D013696:Temperature
D000890:Anti-Infective Agents; D001565:Benzoates; D005520:Food Preservatives; D007463:Iodobenzoates; D007539:Isonicotinic Acids; D008670:Metals; D010848:Picolinic Acids; D009525:Niacin; D007455:Iodine; C030614:picolinic acid