Adrenal corticosteroid biosynthesis, metabolism, and action.
Adrenal corticosteroids are essential for life, and an appreciation of the mechanisms underpinning their synthesis, secretion, and mode of action in normal physiology is essential if the physician is to diagnose and treat patients who have Cushing's syndromes effectively. In each case, there have been clinically significant advances in the knowledge base over recent years, notably in the understanding of steroidogenesis, cortisol action, and metabolism. This article describes corticosteroid biosynthesis, metabolism, and action.
Arlt
Wiebke
W
Division of Medical Sciences, Endocrinology, Institute of Biomedical Research, University of Birmingham, Room 238, Wolfson Drive, Birmingham B15 2TT, UK.
Stewart
Paul M
PM
D000302:Adrenal Cortex / Q000502:physiology*; D000305:Adrenal Cortex Hormones / Q000096:biosynthesis / Q000378:metabolism*; D006801:Humans; D047748:Pituitary ACTH Hypersecretion / Q000378:metabolism* / Q000503:physiopathology
D000305:Adrenal Cortex Hormones