CNS siderosis and dandy-walker variant after neonatal alloimmune thrombocytopenia.
This report presents a case of superficial siderosis of the central nervous system secondary to repeated intraventricular and subarachnoid bleeding of a newborn infant with neonatal alloimmune thrombocytopenia. In addition, this infant manifested Dandy-Walker variant. To date, the few known cases of superficial siderosis in neonates have not been associated with neonatal alloimmune thrombocytopenia or Dandy-Walker complex. We believe that repeated bleeding in the central nervous system from early fetal life, especially in the posterior fossa, may produce cerebellar atrophy as occurs in adults with superficial siderosis of the central nervous system.
Castro Conde
José Ramón
JR
University Hospital of Canary Islands, University of La Laguna, La Laguna, S/C Tenerife, Spain.
Martínez
Eduardo Doménech
ED
Rodríguez
Raúl Cabrera
RC
Rodríguez De Hoyos
Ana Lorena
AL
D002531:Cerebellum / Q000002:abnormalities; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D003616:Dandy-Walker Syndrome / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D012806:Siderosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D013921:Thrombocytopenia / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D014463:Ultrasonography