Rapid, small-scale determination of organic solvent solubility using a thermogravimetric analyzer.
A rapid gravimetric method for determining drug candidate solubility in organic solvents has been developed. The scale, speed, precision, and accuracy of the method make it ideal for solubility screening of pharmaceutical compounds during early development. The method utilizes a thermogravimetric analyzer to automate drying and weighing. Results for model compounds compare favorably with literature values.
Greene
Landon R
LR
Pharmaceutical Research and Development, World Wide Pharmaceutical Sciences, Pfizer Global Research and Development-Ann Arbor Laboratories, MI 48105, USA.
Blackburn
Anthony C
AC
Miller
Jonathan M
JM
D009930:Organic Chemicals / Q000737:chemistry*; D015203:Reproducibility of Results; D012995:Solubility; D012997:Solvents / Q000737:chemistry*
D009930:Organic Chemicals; D012997:Solvents