title: Acustimulation wrist bands are not effective for the control of chemotherapy-induced nausea in women with breast cancer.
abstract: This experiment examined the efficacy of an acustimulation wrist band for the relief of chemotherapy-induced nausea using a randomized three-arm clinical trial (active acustimulation, sham acustimulation, and no acustimulation) in 96 women with breast cancer who experienced nausea at their first chemotherapy treatment. Five outcomes related to wrist band efficacy (acute nausea, delayed nausea, vomiting, QOL, and total amount of antiemetic medication used) were examined. The five outcomes were examined separately using analysis of covariance controlling for age and severity of past nausea. There were no significant differences in any of these study measures among the three treatment conditions (P>0.1 for all). Study results do not support the hypothesis that acustimulation bands are efficacious as an adjunct to pharmacological antiemetics for control of chemotherapy-related nausea in female breast cancer patients.
authors.affiliation: University of Rochester Cancer Center, Rochester General Hospital Cancer Center, New York 14642, USA.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Roscoe
authors.forename: Sara E
authors.initials: SE
authors.lastname: Matteson
authors.forename: Gary R
authors.initials: GR
authors.lastname: Morrow
authors.forename: Jane T
authors.initials: JT
authors.lastname: Hickok
authors.forename: Peter
authors.initials: P
authors.lastname: Bushunow
authors.forename: Jennifer
authors.initials: J
authors.lastname: Griggs
authors.forename: Raman
authors.initials: R
authors.lastname: Qazi
authors.forename: Brian
authors.initials: B
authors.lastname: Smith
authors.forename: Zachary
authors.initials: Z
authors.lastname: Kramer
authors.forename: Julia
authors.initials: J
authors.lastname: Smith
mesh_terms: D015670:Acupuncture Therapy / Q000379:methods*; D000328:Adult; D000368:Aged; D000932:Antiemetics / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy; D003131:Combined Modality Therapy / Q000379:methods; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced* / Q000188:drug therapy / Q000517:prevention & control*; D004561:Transcutaneous Electric Nerve Stimulation / Q000379:methods*; D014953:Wrist / Q000294:innervation / Q000503:physiopathology
chemical_list: D000932:Antiemetics; D000970:Antineoplastic Agents; D004317:Doxorubicin; D003520:Cyclophosphamide