Synthesis of pyrrolo[2,1-c][1,4]benzodiazepines and their conjugates by azido reductive cyclization strategy as potential DNA-binding agents.
Synthesis of pyrrolo[2,1-c][1,4]benzodiazepines via azido reductive cyclization process employing FeCl3-NaI reagent system. This methodology has been extended for the preparation of new nicotinamido-pyrrolobenzodiazepine hybrids linked through piperazino-alkane-oxy spacers that exhibit good DNA binding affinity.
Kamal
Ahmed
A
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India.
Babu
A Hari
AH
Ramana
A Venkata
AV
Ramana
K Venkata
KV
Bharathi
E Vijaya
EV
Kumar
M Shiva
MS
D001386:Azides / Q000737:chemistry*; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D004587:Electrophoresis, Agar Gel
D001386:Azides; D001569:Benzodiazepines; D004247:DNA