title: Effect of tequila on homocysteine, insulin secretion, insulin sensitivity, and metabolic profile in healthy men.
abstract: OBJECTIVE
  The purpose of this study is to identify the effect of a low dose of tequila on homocysteine, insulin secretion, insulin sensitivity, and metabolic profile in healthy young men.
  
  
  METHODS
  An open clinical trial was carried out in eight healthy nonobese, young male volunteers. The study was divided in two phases. The first one evaluated metabolic changes, including insulin secretion and sensitivity due to acute administration of 30 ml of straight tequila. The second phase of the study evaluated metabolic effects due to the daily administration of 30 ml of tequila during 30 days.
  
  
  RESULTS
  There were no significant metabolic changes after the single oral administration of 30 ml of straight tequila. After the administration of tequila during 30 days, a significant increase in homocysteine levels and a tendency to increase the glucose concentration and to decrease the insulin sensitivity were found.
  
  
  CONCLUSIONS
  Detrimental metabolic changes were observed with the daily administration of 30 ml of tequila during 30 days.
authors.affiliation: Medical Research Unit in Clinical Epidemiology, West National Medical Center, Mexican Institute of Social Security, Guadalajara, Mexico. uiec@prodigy.net.mx
authors.forename: Manuel
authors.initials: M
authors.lastname: González-Ortiz
authors.forename: Sara
authors.initials: S
authors.lastname: Pascoe-González
authors.forename: Angélica M
authors.initials: AM
authors.lastname: Kam-Ramos
authors.forename: Esperanza
authors.initials: E
authors.lastname: Martínez-Abundis
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000503:physiopathology*; D000434:Alcoholic Beverages / Q000009:adverse effects; D001786:Blood Glucose / Q000378:metabolism; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D012016:Reference Values
chemical_list: D001786:Blood Glucose; D007328:Insulin; D006710:Homocysteine