Serum leptin and erythropoietin during menstruation.
OBJECTIVE
The potential influence of leptin and erythropoietin on the angiogenesis and bleeding of the endometrium during normal menstrual cycles and possible correlations between them.


METHODS
Serum concentrations of leptin and erythopoietin were measured at menstrual days 20, 1 and 3 or 4 in healthy, non-obese, normal menstruating women.


RESULTS
Mean leptin and erythropoietin concentrations showed no significant alteration over time (F = 0.588, p = 0.563 and F = 0.654, p = 0.528, respectively). There was, however, a strong negative linear relationship between the concentration of the two substances on days 1 and 3 or 4 (p = 0.018 and p = 0.028, respectively).


CONCLUSIONS
If the two substances affect endometrial angiogenesis, they may do this in a locally limited way, so that peripheral concentration changes cannot be observed. Their inverse correlation prompts further study with receptor determination.
Stefos
Th
T
Obstetrics and Gynecology Department, University Hospital of Ioannina Greece.
Sotiriadis
A
A
Tsanadis
G
G
Hasiotis
G
G
Papanicolaou
E
E
Seferiadis
K
K
D000328:Adult; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008597:Menstrual Cycle / Q000097:blood*
D020738:Leptin; D004921:Erythropoietin