title: Establishment and characterization of JHUCS-1 cell line derived from carcinosarcoma of the human uterus.
abstract: The cell line designed JHUCS-1 was established from a carcinosarcoma (malignant mixed mesodermal tumor) of the uterus that was surgically removed from a 57-year-old Japanese woman. We carefully examined the histopathology of the original tumor after the cell line was established and noted differentiation into a neuroendocrine carcinoma within the tumor's epithelial components. Immunohistochemical staining of the tumorous tissue that had been heterotransplanted was positive for Leu7. Additionally, secretary granules were observed in the grafted cells as determined by electron microscopy. These results support the existence of neuroendocrine cells within the JHUCS-1 cell line.
authors.affiliation: Department of Obstetrics and Gynecology, The Jikei University School of Medicine.
authors.forename: Kyosuke
authors.initials: K
authors.lastname: Yamada
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Tachibana
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Iida
authors.forename: Kazu
authors.initials: K
authors.lastname: Ueda
authors.forename: Akihiko
authors.initials: A
authors.lastname: Misawa
authors.forename: Nagazumi
authors.initials: N
authors.lastname: Suzuki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kato
authors.forename: Eizo
authors.initials: E
authors.lastname: Kimura
authors.forename: Makoto
authors.initials: M
authors.lastname: Yasuda
authors.forename: Tadao
authors.initials: T
authors.lastname: Tanaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishikawa
mesh_terms: D000818:Animals; D018959:CD57 Antigens; D018278:Carcinoma, Neuroendocrine / Q000235:genetics / Q000473:pathology* / Q000648:ultrastructure; D002296:Carcinosarcoma / Q000473:pathology*; D018929:Cell Culture Techniques / Q000379:methods*; D045744:Cell Line, Tumor; D002471:Cell Transformation, Neoplastic; D002874:Chromosome Mapping; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008854:Microscopy, Electron; D008875:Middle Aged; D009368:Neoplasm Transplantation; D014594:Uterine Neoplasms / Q000473:pathology*
chemical_list: D018959:CD57 Antigens