title: Efficacy of the kampo medicine xiong-gui-tiao-xue-yin (kyuki-chouketsu-in), a traditional herbal medicine, in the treatment of maternity blues syndrome in the postpartum period.
abstract: This study was to evaluate the clinical efficacy of Xiong-gui-tiao-xue-yin (Kyuki-chouketsu-in), a Japanese traditional herbal medicine, in stabilizing postpartum psychological state. We enrolled 268 women who had a normal delivery in Osaka Medical College Hospital or its affiliated clinics and randomly assigned them to the following two groups: a group of 134 women who received Xiong-gui-tiao-xue-yin (Kyuki-chouketsu-in) at a dose of 6.0 g/day and another group of 134 women without Xiong-gui-tiao-xue-yin (Kyuki-chouketsu-in) (control group). We observed 2.06-fold and 1.67-fold higher incidences of depressive mood and nervousness, respectively, after delivery in the control group than in the Xiong-gui-tiao-xue-yin (Kyuki-chouketsu-in) group. Within 3 weeks of postpartum, there was a significant difference in the incidences of maternity blues between the Xiong-gui-tiao-xue-yin (Kyuki-chouketsu-in) group (15.7%; 21/134) and the control group (32.1%; 43/134) (p = 0.0195). No adverse effects were observed in this study. The results of this study demonstrate the beneficial clinical effects of Xiong-gui-tiao-xue-yin (Kyuki-chouketsu-in) in stabilizing psychological state in the postpartum period. Xiong-gui-tiao-xue-yin (Kyuki-chouketsu-in) can be expected to improve the mental health of women in the postpartum period and prevent maternity blues.
authors.affiliation: Department of Obstetrics and Gynecology, Osaka Medical College Takatsuki, Osaka 568-8686, Japan. gyn003@poh.osaka-med.ac.jp
authors.forename: Takahisa
authors.initials: T
authors.lastname: Ushiroyama
authors.forename: Kou
authors.initials: K
authors.lastname: Sakuma
authors.forename: Minoru
authors.initials: M
authors.lastname: Ueki
mesh_terms: D000328:Adult; D029969:Angelica; D031048:Cnidium; D019052:Depression, Postpartum / Q000188:drug therapy* / Q000453:epidemiology / Q000523:psychology; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D015994:Incidence; D020835:Medicine, Kampo; D049590:Postpartum Period
chemical_list: D004365:Drugs, Chinese Herbal