Cardiovascular toxicity from the perspective of oxidative stress, electron transfer, and prevention by antioxidants.
This review demonstrates that oxidative stress, reactive oxygen species, and electron transfer can serve as unifying mechanistic themes for large numbers of cardiovascular toxins, both endogenous and exogenous. Lipid peroxidation is a prevalent insult. Common among the various conditions are atherosclerosis and arrhythmia. The preventive effects of antioxidants are documented.
Kovacic
Peter
P
Department of Chemistry, San Diego State University, San Diego, CA 92182-1030, USA. pkovacic@sundown.sdsu.edu
Thurn
Lisa A
LA
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002318:Cardiovascular Diseases / Q000139:chemically induced* / Q000517:prevention & control*; D004579:Electron Transport / Q000187:drug effects*; D004785:Environmental Pollutants / Q000633:toxicity; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
D000975:Antioxidants; D004785:Environmental Pollutants; D017382:Reactive Oxygen Species