Synthesis of carbamate-linked lipids for gene delivery.
Series of lipids 1a-d and 2a,b, with carbamate linkages between hydrocarbon chains and ammonium or tertiary amine head, which were pH sensitive, were synthesized for liposome-mediated gene delivery. The variable length of carbon chains and quaternary ammonium or neutral tertiary amine heads allowed to find the structure-function relationship of how these factors affect cationic lipids on gene delivery performance.
Liu
Dongliang
D
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China. dut-liu@163.com
Hu
Jianjun
J
Qiao
Weihong
W
Li
Zongshi
Z
Zhang
Shubiao
S
Cheng
Lvbo
L
D002219:Carbamates / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D004337:Drug Carriers; D015316:Genetic Therapy; D050356:Lipid Metabolism; D008055:Lipids / Q000138:chemical synthesis*; D008081:Liposomes / Q000737:chemistry*
D002219:Carbamates; D004337:Drug Carriers; D008055:Lipids; D008081:Liposomes