Genetic association study of adiponectin polymorphisms with risk of Type 2 diabetes mellitus in Korean population.
OBJECTIVE
To investigate any association between Type 2 diabetes mellitus and two single nucleotide polymorphisms (SNPs) in the adiponectin gene, T45G and G276T, in the Korean population.


METHODS
We genotyped 427 non-diabetic controls and 493 Type 2 diabetic patients for SNPs T45G and G276T of adiponectin gene, measured plasma adiponectin concentrations, and examined clinical parameters in Koreans.


RESULTS
There were no statistically significant differences in allele frequencies of SNPs 45 and 276 comparing control with Type 2 diabetic subjects (T frequency 68.3% vs. 71.6%, P=0.13 for SNP45, G frequency 72.2% vs. 68.9%, P=0.12 for SNP276). The genotype distributions of these SNPs had no association with the risk of Type 2 diabetes and metabolic parameters of insulin resistance. Plasma levels of adiponectin were not statistically different according to T45G and G276T either, in both control and Type 2 diabetic subjects.


CONCLUSIONS
The T45G and G276T of the adiponectin gene may not be an important determinant of Type 2 diabetes or insulin resistance in Korean subjects.
Lee
Y Y
YY
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Lee
N S
NS
Cho
Y M
YM
Moon
M K
MK
Jung
H S
HS
Park
Y J
YJ
Park
H J
HJ
Youn
B S
BS
Lee
H K
HK
Park
K S
KS
Shin
H D
HD
D052242:Adiponectin; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007333:Insulin Resistance / Q000208:ethnology / Q000235:genetics; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics; D007723:Korea / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
D052242:Adiponectin; D036341:Intercellular Signaling Peptides and Proteins