Inositide evolution - towards turtle domination?
When viewing the changes in our understanding of inositides over the last 20 years, it is difficult to know whether to be more impressed by the proliferation in the number of inositides themselves (e.g. seven polyphosphoinositol lipids, more than 30 inositol phosphates), or by the number of functions for each. This review will focus on two specific aspects of this diversity: the evolution of the polyphosphoinositides, and the synthesis and functions of the higher inositol phosphates.
Irvine
Robin F
RF
Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK. rfi20@cam.ac.uk
D000818:Animals; D005075:Biological Evolution; D006801:Humans; D007294:Inositol / Q000502:physiology; D007295:Inositol Phosphates / Q000737:chemistry / Q000502:physiology*
D007295:Inositol Phosphates; D007294:Inositol