Preservation of DNA integrity and neuronal degeneration.
The mismatch repair system (MMR) is an important member of the DNA checkpoint, that includes a number of protein deputed to control genomic stability through cell cycle arrest, DNA repair, and apoptosis. Here we summarize some recent data from our and other groups underlining the contribution to neurodegeneration of MSH2, perhaps the most relevant component of the MMR system. These data suggest that this protein participates not only in the cancer prevention machinery for the body but also in neurodegenerative processes.
Francisconi
Simona
S
Department of Biomedical Sciences and Biotechnologies, University of Brescia, Medical School, Italy.
Codenotti
Mara
M
Ferrari-Toninelli
Giulia
G
Uberti
Daniela
D
Memo
Maurizio
M
D000818:Animals; D017209:Apoptosis; D020137:Base Pair Mismatch; D004260:DNA Repair / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D051718:MutS Homolog 2 Protein; D009410:Nerve Degeneration / Q000209:etiology / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000378:metabolism
D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; C497172:MSH2 protein, human; D051718:MutS Homolog 2 Protein