How do conventional markers of lipid disorders compare with apolipoproteins?
Assessment of risk for coronary heart disease (CHD) indicates that apolipoprotein B and apolipoprotein A-I and their ratio are efficient predictors, possibly superior to hitherto used indicators, i.e. S-Cholesterol, S-Triglycerides, S-HDL cholesterol and S-LDL cholesterol. We used the ratio S-Apolipoprotein B/S-Apolipoprotein A-I as the gold standard to compare the diagnostic performance of the other properties based on consecutive routine measurements in patients attending primary health-care or a university hospital. The different cut-offs of the S-Apolipoprotein B/S-Apolipoprotein A-I ratio that were investigated created a prevalence of risk factors that might require intervention in the study group between 10 and 77%. The gender difference prompts for a partitioning related to the gender, whereas the changes related to age were small and were disregarded. The diagnostic sensitivity and specificity were demonstrated in ROC diagrams for the studied properties.
Estonius
M
M
Department of Clinical Chemistry, Karolinska University Laboratory, Karolinska University Hospital at Solna, Stockholm, Sweden.
Kallner
A
A
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001053:Apolipoproteins / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002648:Child; D003327:Coronary Disease / Q000097:blood; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012727:Sex Characteristics
D001053:Apolipoproteins; D015415:Biomarkers; D008055:Lipids