Maternal death after second-trimester genetic amniocentesis.
BACKGROUND
We report a maternal death after a second-trimester amniocentesis.


METHODS
An uncomplicated amniocentesis was performed using sterile technique and ultrasound guidance. A refrigerated amniotic fluid specimen demonstrated negative leukocyte esterase activity, negative Gram stain for bacteria and white blood cells, and normal glucose and interleukin-6. The patient died from Escherichia coli sepsis and disseminated intravascular coagulation 40 hours after the amniocentesis. The autopsy showed normal- appearing needle entries into the skin and uterus without evidence of bowel adhesion or a needle track through the bowel.


CONCLUSIONS
Genetic counselors and obstetric care providers should be aware of potential serious maternal morbidity and mortality that may occur subsequent to uncomplicated amniocentesis.
Thorp
James A
JA
Regional Perinatal Center, Sacred Heart Women's Hospital, Pensacola, USA.
Helfgott
Andrew W
AW
King
Elizabeth A
EA
King
Aaron A
AA
Minyard
Andrea N
AN
D000328:Adult; D000649:Amniocentesis / Q000009:adverse effects* / Q000379:methods; D016470:Bacteremia / Q000175:diagnosis*; D018450:Disease Progression; D004926:Escherichia coli / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000175:diagnosis* / Q000628:therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D010298:Parity; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011295:Prenatal Care / Q000379:methods; D018570:Risk Assessment; D012720:Severity of Illness Index