title: A case of long QT syndrome associated with familial occurrence of persistent patency of the arterial duct.
abstract: We describe an occurrence of long QT syndrome in association with persistent patency of the arterial duct in members of a family. Patency of the arterial duct was diagnosed in family members of 4 successive generations. The index case had long QT syndrome associated with such a patent duct. Another patient had long QT syndrome, but associated with a ventricular septal defect. We postulate that there may be a common genetic mechanism for long QT syndrome and persistent patency of the arterial duct.
authors.affiliation: Department of Congenital Heart Disease and Clinical Genetics, Leeds General Infirmary, Leeds, United Kingdom. jothidevi1@hotmail.com
authors.forename: Subramanian Jothi
authors.initials: SJ
authors.lastname: Murugan
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Parsons
authors.forename: Chris
authors.initials: C
authors.lastname: Bennett
mesh_terms: D001146:Arrhythmia, Sinus / Q000209:etiology; D001919:Bradycardia / Q000209:etiology; D002648:Child; D004374:Ductus Arteriosus, Patent / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008133:Long QT Syndrome / Q000209:etiology*; D010375:Pedigree; D013575:Syncope / Q000209:etiology