title: Restless legs syndrome associated with primary hyperparathyroidism.
abstract: Restless legs syndrome (RLS) is a poorly understood sleep-related movement disorder which can be primary or associated with other conditions, most commonly iron deficiency, uremia and peripheral nerve disease. We present a case of RLS with an unusual secondary cause: primary hyperparathyroidism with hypercalcemia. This patient experienced complete and sustained relief of RLS symptoms immediately after parathyroidectomy, with normalization of her serum parathyroid hormone (PTH) and calcium levels. Early recognition and treatment of this uncommonly detected underlying cause is important because it is potentially curative in this frequently disabling condition for which usually only symptomatic treatment is available.
authors.affiliation: Department of Neurology, Cleveland Clinic Foundation, Cleveland, OH, USA. lilinglim@aol.com
authors.forename: Li Ling
authors.initials: LL
authors.lastname: Lim
authors.forename: Dudley
authors.initials: D
authors.lastname: Dinner
authors.forename: Kwang Wei
authors.initials: KW
authors.lastname: Tham
authors.forename: Elias
authors.initials: E
authors.lastname: Siraj
authors.forename: Robert
authors.initials: R
authors.lastname: Shields
mesh_terms: D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000150:complications; D006961:Hyperparathyroidism / Q000150:complications* / Q000601:surgery; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D017286:Polysomnography; D012148:Restless Legs Syndrome / Q000175:diagnosis / Q000209:etiology*
chemical_list: D010281:Parathyroid Hormone