Oxidative stress in heroin administered mice and natural antioxidants protection.
The oxidative stress of heroin administered mice via intraperitoneal injection, and the therapeutic effects of exogenous antioxidants on the restrain of the oxidative damage of biomolecules and withdrawal syndrome were studied. After administered with heroin, mice showed decrease of total antioxidant capacity in blood, increase of reactive oxygen species production in white blood cells, and increase of oxidative damages of protein and lipid in brain and liver, but not in heart. On the other hand, exogenous antioxidants could restrain the oxidative stress, even alleviate withdrawal syndrome.
Pan
Jing
J
School of Life Sciences, Lanzhou University, Lanzhou 730000, P.R.China.
Zhang
Qi
Q
Zhang
Yuntao
Y
Ouyang
Zhuqing
Z
Zheng
Qiusheng
Q
Zheng
Rongliang
R
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D005260:Female; D006556:Heroin Dependence / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D009206:Myocardium / Q000378:metabolism; D018384:Oxidative Stress; D017382:Reactive Oxygen Species; D013375:Substance Withdrawal Syndrome / Q000378:metabolism / Q000517:prevention & control
D000975:Antioxidants; D017382:Reactive Oxygen Species