title: RBM15-MKL1 (OTT-MAL) fusion transcript in an adult acute myeloid leukemia patient.
abstract: The t(1;22)(p13;q13) is a nonrandom chromosomal abnormality in acute leukemia with the fusion oncogene, RBM15-MKL1 (OTT-MAL), identified recently. However, this abnormality has been described only in infants and young children with acute megakaryoblastic leukemia (AMKL). We report a 59-year-old male patient with the diagnosis of acute myeloid leukemia, subtype M1, who harbors an abnormal chromosome +der(1)t(1;22)(p13;q13). The RBM15-MKL1 (OTT-MAL) fusion transcript was also confirmed by the reverse transcriptase-polymerase chain reaction. This unusual abnormality is rare in adult cases of leukemia, and in children it is restricted to AMKL. This report is accompanied by a review of the literature on the t(1;22)(p13;q13).
authors.affiliation: Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors.forename: Hui-Hua
authors.initials: HH
authors.lastname: Hsiao
authors.forename: Ming-Yu
authors.initials: MY
authors.lastname: Yang
authors.forename: Yi-Chang
authors.initials: YC
authors.lastname: Liu
authors.forename: Hui-Pin
authors.initials: HP
authors.lastname: Hsiao
authors.forename: Shih-Bin
authors.initials: SB
authors.lastname: Tseng
authors.forename: Mei-Chyn
authors.initials: MC
authors.lastname: Chao
authors.forename: Ta-Chih
authors.initials: TC
authors.lastname: Liu
authors.forename: Sheng-Fung
authors.initials: SF
authors.lastname: Lin
mesh_terms: D000208:Acute Disease; D000328:Adult; D001483:Base Sequence; D002878:Chromosomes, Human, Pair 1; D002895:Chromosomes, Human, Pair 5; D017931:DNA Primers; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015534:Trans-Activators; D014178:Translocation, Genetic
chemical_list: D017931:DNA Primers; D004268:DNA-Binding Proteins; C431575:MRTFA protein, human; D015514:Oncogene Proteins, Fusion; C431574:RBM15 protein, human; D016601:RNA-Binding Proteins; D015534:Trans-Activators