[Effects of landiolol hydrochloride on cardiohemodynamics in patients who underwent coronary artery bypass grafting].
BACKGROUND
It is important to control heart rate for coronary artery bypass grafting. The purpose of this study was to evaluate the effects of landiolol hydrochloride, ultra-short-acting beta-blocker, on cardiohemodynamics in 10 patients who underwent coronary artery bypass grafting.


METHODS
Anesthesia was induced and maintained with midazolam and fentanyl. After stabilization of anesthesia, landiolol hydrochloride was administered at a rate of 0.04 mg x kg(-1) x min(-1) for 30 min after 0.125 mg x kg(-1) x min(-1). Hemodynamic measurements were made before and every 5 min after administration of landiolol hydrochloride.


RESULTS
Heart rate decreased significantly although arterial pressure was unchanged. There were no changes in cardiac index, left ventricular stroke volume index, systemic vascular resistances and pulmonary vascular resistance after landiolol hydrochloride administration.


CONCLUSIONS
These results suggest that landiolol hydrochloride possesses less negative inotropic action than negative chronotropic action. Landiolol hydrochloride did not affect both systemic and pulmonary vascular resistances because of high cardioselectivity.
Iwasawa
Ken
K
Department of Anesthesiology, Nagano Red-Cross Hospital, Nagano.
Nakagawa
Hideyuki
H
Katou
Mikiyoshi
M
Yonezawa
Kaori
K
Nishizawa
Masaaki
M
Yanagiya
Nobuyuki
N
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002496:Central Venous Pressure / Q000187:drug effects; D001026:Coronary Artery Bypass; D003864:Depression, Chemical; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009025:Morpholines / Q000494:pharmacology*; D014508:Urea / Q000031:analogs & derivatives* / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D009025:Morpholines; C077049:landiolol; D014508:Urea