title: Intercedensides D-I, cytotoxic triterpene glycosides from the sea cucumber Mensamaria intercedens Lampert.
abstract: Six new triterpene glycosides, intercedensides D-I (1-6), were isolated from the whole bodies of the sea cucumber Mensamria intercedens Lampert, which is found in the South China Sea. Their structures were elucidated by extensive spectroscopic analysis (NMR and ESIMS) and chemical methods. lntercedensides D (1), E (2), G (4), and H (5) have a conjugated double bond system (22Z,24-diene) in the aglycon side chain, while intercedensides F (3) and I (6) have only a single double bond (24, 25) in this same chain. lntercedensides D-H (1-5) showed significant cytotoxicity (ED(50) 0.96-5.0 mug/mL) against 10 human tumor cell lines.
authors.affiliation: Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, People's Republic of China.
authors.forename: Zhengrong
authors.initials: Z
authors.lastname: Zou
authors.forename: Yanghua
authors.initials: Y
authors.lastname: Yi
authors.forename: Houming
authors.initials: H
authors.lastname: Wu
authors.forename: Xinsheng
authors.initials: X
authors.lastname: Yao
authors.forename: Lijun
authors.initials: L
authors.lastname: Du
authors.forename: Wu
authors.initials: W
authors.lastname: Jiuhong
authors.forename: Chih-Chaung
authors.initials: CC
authors.lastname: Liaw
authors.forename: Kuo-Hsiung
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular; D012616:Sea Cucumbers / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D006027:Glycosides; D014315:Triterpenes