title: [Effect of weight loss induced by laparoscopic adjustable gastric banding on immunity of morbid obesity].
abstract: OBJECTIVE
  To compare the immunity of morbid obesity (MO) before and after laparoscopic adjustable gastric banding (LAGB).
  
  
  METHODS
  15 cases, with a mean body mass index (BMI) of 35.8 kg/m(2), were treated by LAGB from Jun. 2003 to Oct. 2003 in our department. Patients' immune parameters were determined preoperatively and 1, 3 and 6 months postoperatively. 15 cases with a normal BMI (23.6 kg/m(2)) were set as controls.
  
  
  RESULTS
  Before surgery, the MO had a significant lower level of CD(4)(+), CD(4)(+)/CD(8)(+) and a higher level of serum interleukin-2 (IL-2), Interleukin-6 (IL-6) than the controls (P < 0.01). There was a significant reduction of weight and BMI 6 months postoperatively (P < 0.01). At the same time, CD(4)(+) increased and serum IL-2 decreased significantly. But CD(4)(+)/CD(8)(+)and serum IL-2, IL-6 were still abnormal compare to the controls.
  
  
  CONCLUSIONS
  MO may combined with an abnormal immunity. But after enough weight loss induced by LAGB, it can be partly reversed.
authors.affiliation: Department of Microinvasive Surgery, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China. hmg780305@sina.com.cn
authors.forename: Ming-gen
authors.initials: MG
authors.lastname: Hu
authors.forename: Cheng-zhu
authors.initials: CZ
authors.lastname: Zheng
authors.forename: Chong-wei
authors.initials: CW
authors.lastname: Ke
authors.forename: Kai
authors.initials: K
authors.lastname: Yin
authors.forename: Ji-hui
authors.initials: JH
authors.lastname: Li
authors.forename: Bin
authors.initials: B
authors.lastname: Hu
authors.forename: Yue-feng
authors.initials: YF
authors.lastname: Wu
authors.forename: Ping
authors.initials: P
authors.lastname: Cao
authors.forename: Da-jin
authors.initials: DJ
authors.lastname: Zou
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D015391:Gastroplasty / Q000379:methods*; D006801:Humans; D010535:Laparoscopy; D008297:Male; D009767:Obesity, Morbid / Q000276:immunology / Q000601:surgery*; D015431:Weight Loss