Pallidal stimulation reduces treatment-induced dyskinesias in "minimal-change" multiple system atrophy.
Deep brain stimulation therapy is increasingly gaining acceptance in the management of levodopa-induced dyskinesia and fluctuations in idiopathic Parkinson's disease. It is generally not recommended for the other forms of parkinsonism such as progressive supranuclear palsy or multiple system atrophy where the response to levodopa is usually poor and disease progression more rapid, making any benefit short-lived. Here, we present an autopsy-confirmed case of "minimal-change" multiple system atrophy in whom pallidal stimulation surgery was effective in abolishing severe levodopa-induced dyskinesia.
Huang
Yue
Y
Prince of Wales Medical Research Institute and University of New South Wales, Randwick, Australia.
Garrick
Raymond
R
Cook
Raymond
R
O'Sullivan
Dudley
D
Morris
John
J
Halliday
Glenda M
GM
D046690:Deep Brain Stimulation / Q000379:methods*; D004409:Dyskinesia, Drug-Induced / Q000209:etiology / Q000628:therapy*; D005260:Female; D007839:Functional Laterality; D005917:Globus Pallidus / Q000528:radiation effects*; D006801:Humans; D007150:Immunohistochemistry; D007980:Levodopa / Q000009:adverse effects; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000503:physiopathology / Q000628:therapy*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009483:Neuropsychological Tests; D013194:Staining and Labeling; D051843:Synucleins; D025801:Ubiquitin / Q000378:metabolism
D009419:Nerve Tissue Proteins; D051843:Synucleins; D025801:Ubiquitin; D007980:Levodopa