Severe seizures during propofol induction in a patient with syringomyelia receiving baclofen.
We report the occurrence of recurrent severe generalized seizures during induction of anesthesia with propofol in a patient with syringomyelia receiving baclofen for flexor spasms undergoing neurosurgery. We discuss the possible epileptogenic interaction between baclofen and propofol in our patient.
Manikandan
Sethuraman
S
Department of Anesthesiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala.
Sinha
Prabhat K
PK
Neema
Praveen K
PK
Rathod
Ramesh C
RC
D001418:Baclofen / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000009:adverse effects*; D018080:Receptors, GABA-B / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced*; D013595:Syringomyelia / Q000188:drug therapy*
D018080:Receptors, GABA-B; D001418:Baclofen; D015742:Propofol