[Usefulness of luteinizant hormone levels to determine the oocyte quality].
OBJECTIVE
To evaluate the luteinizing hormone serum preovulatory levels and correlate them with the embryo number and quality, and with the fertilization and clavage rates.


METHODS
Prospective, descriptive and observational.


METHODS
We included 286 patients that underwent to IVF-ET program, we excluded patients with no mesurement of LH preovulatory levels, or patients that in the oocyte retrieval we do not found oocytes. The protocols for pituitary inhibition were: stop Lupron, long luteal phase and GnRH antagonist, the ovarian stimulation was realized with recombinant FSH. The studied variables were: LH preovulatory levels, number and quality of oocytes, fertilization and clevage rates and embryo quality. Statistical analysis was done with p Pearson and ANOVA tests.


RESULTS
The mean age for patients was 34 +/- 3.96 years, the principal factor of infertility was tubal and pelvis pathology. The mean LH preovulatory levels were 2.19 +/- 1.83 UI/L by patient, we observed a negative correlation between LH levels and number of oocytes retrieved (p = -0.157, IC 99%), and the correlation between LH levels and number of metaphase 2 oocyte was negative too (p = 0.113, IC 95%). We observed greater levels of LH (3.15 UI/L) in the degenerated oocytes during oocyte retrieval. We did not found a statistical correlation between fertilization and cleavage rates with LH levels. LH preovulatory levels of 0.85 UI/L could predict good quality oocytes with a sensitivity of 72% and specificity of 25%.


CONCLUSIONS
Normogonadotrophic patients without deep suppression of gonadotrophins by the use of GnRH analogues, high LH preovulatory levels correlates with a less number of oocytes, and with degenerated oocytes. Preovulatory LH levels of 0.85 UI/L could predict good quality oocytes.
Ruiz Anguas
Julián
J
Unidad de reproducción asistida, Centro Especializado para la Atención de la Mujer, Hospital Angeles de las Lomas, Estado de México. drjruiz@prodigy.net.mx
Carballo Mondragón
Esperanza
E
Anta Jaen
Everardo
E
Díaz Calvillo
Jenny
J
Kably Ambe
Alberto
A
D000328:Adult; D000704:Analysis of Variance; D003627:Data Interpretation, Statistical; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007247:Infertility, Female / Q000209:etiology; D007986:Luteinizing Hormone / Q000097:blood*; D009865:Oocytes / Q000502:physiology*; D011446:Prospective Studies; D012372:ROC Curve; D011863:Radioimmunoassay; D012680:Sensitivity and Specificity; D020554:Sperm Injections, Intracytoplasmic
D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone