title: [Intervention of antioxidant system function of aged rats by giving fruit juices with different antioxidant capacities].
abstract: OBJECTIVE
  To observe the effects of fruit juices with different antioxidant capacity on antioxidant system function of aged rats.
  
  
  METHODS
  Thirty Wistar rats were randomly divided into three groups: pomegranate juice and apple juice as two experimental groups, while distilled water as normal control group. They were administrated fruit juices or distilled water respectively by gavage daily for 4 weeks. At the end of experiment, the antioxidant system function was assessed.
  
  
  RESULTS
  The aged rats in pomegranate juice group showed significantly higher serum antioxidant capacity (0.90 +/- 0.13) mmol/L than that in control group (0.79 +/- 0.10) mmol/L (P < 0.05). The concentrations of serum carbonyl and oxLDL were decreased significantly in pomegranate juice group as compared to the control group (P < 0.05). The percentage of injured blood lymphocyte DNA and the ratio of tail length/total length were declined significantly in pomegranate juice group (P < 0.05 and P < 0.01 respectively). The apple juice showed no effects except decreased ratio of tail length/total length of injured lymphocyte DNA. There were no changes in concentrations of serum vitamin C, vitamin E, urinary 8-OH-dG excretion and the activities of serum SOD, GSH-Px, CAT among three groups.
  
  
  CONCLUSIONS
  The pomegranate juice should possess higher antioxidant capacity and might improve the antioxidant system function of aged rats, while the apple juice is relatively lower in antioxidant capacity and not very effective. The polyphenols in pomegranate juice might be the important functional components.
authors.affiliation: Department of Nutrition, Institute of Hygiene and Environmental Medicine, Acedemy of Military Medical Sciences, Tianjin 300050, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Chang-jiang
authors.initials: CJ
authors.lastname: Guo
authors.forename: Ji-jun
authors.initials: JJ
authors.lastname: Yang
authors.forename: Jing-yu
authors.initials: JY
authors.lastname: Wei
authors.forename: Yun-feng
authors.initials: YF
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Pang
authors.forename: Yu-gang
authors.initials: YG
authors.lastname: Jiang
authors.forename: Shuang
authors.initials: S
authors.lastname: Cheng
mesh_terms: D000375:Aging; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism*; D001205:Ascorbic Acid / Q000097:blood; D001628:Beverages; D002374:Catalase / Q000097:blood; D020552:Comet Assay; D005260:Female; D005638:Fruit / Q000737:chemistry*; D005979:Glutathione Peroxidase / Q000097:blood; D008214:Lymphocytes / Q000378:metabolism; D029561:Lythraceae / Q000737:chemistry; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000652:urine; D027845:Malus / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood; D014810:Vitamin E / Q000097:blood
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D001205:Ascorbic Acid