Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate.
Humans appear to be refractory to some effects of peroxisome proliferators including alterations in cell proliferation, whereas rodents are susceptible. In this study, differences between the human and rat response to peroxisome proliferators were evaluated using rat and human tumour liver cell lines. Rat 7777 cells were more responsive than human HepG2 cells to ciprofibrate as they exhibited a higher decrease in cell number than HepG2, and underwent apoptosis. Results from these studies reveal a surprising response in tumour cell lines as the typical in vivo response of increased cell proliferation and reduced apoptosis was not observed in rat tumour cell lines at concentrations greater than those used to elicit the former response.
Clemencet
Marie-Claude
MC
Laboratoire de Biologie Moléculaire et Cellulaire (EA 2978-GDR-CNRS No. 2583), Faculté des Sciences Gabriel, Université de Bourgogne, 6, bd Gabriel 21000 Dijon, France.
Muzio
Giuliana
G
Trombetta
Antonella
A
Peters
Jeffrey M
JM
Gonzalez
Frank J
FJ
Canuto
Rosa A
RA
Latruffe
Norbert
N
D000818:Animals; D017209:Apoptosis; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects*; D002995:Clofibric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D058607:Fibric Acids; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008099:Liver / Q000166:cytology*; D051381:Rats
D058607:Fibric Acids; D000960:Hypolipidemic Agents; D002995:Clofibric Acid; C019304:ciprofibrate