title: Hypermutable and fluoroquinolone-resistant clinical isolates of Staphylococcus aureus.
abstract: Over 124 methicillin-susceptible Staphylococcus aureus 0/74 fluoroquinolone-susceptible versus 5/50 fluoroquinolone-resistant isolates were hypermutable. Hypermutable isolates combined mutations in gyrA, parC, and/or parE genes. One strain had a large deletion of the mutator mutS and mutL genes. No relevant mutation in mutS and mutL genes was found in the other isolates.
authors.affiliation: Service de Microbiologie and EA 2128 Relations hôte et microorganismes des épithéliums, Hôpital Côte de Nacre, Université de Caen, 14033 Caen Cedex, France.
authors.forename: Hiep N'Guyen
authors.initials: HN
authors.lastname: Trong
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Prunier
authors.forename: Roland
authors.initials: R
authors.lastname: Leclercq
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D017931:DNA Primers; D004261:DNA Replication; D024881:Drug Resistance, Bacterial; D024841:Fluoroquinolones / Q000494:pharmacology*; D005798:Genes, Bacterial / Q000235:genetics; D016106:Methicillin Resistance; D009154:Mutation / Q000235:genetics / Q000502:physiology; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics*
chemical_list: D000890:Anti-Infective Agents; D017931:DNA Primers; D024841:Fluoroquinolones