title: Prilocaine plasma levels and methemoglobinemia in patients undergoing tumescent liposuction involving less than 2,000 ml.
abstract: BACKGROUND
  As a reaction to reported adverse outcomes after lidocaine infiltration in tumescent liposuction, prilocaine has gained increasing popularity. Previous studies investigating large-volume liposuction procedures found maximum prilocaine levels and methemoglobinemia up to 12 h postoperatively, suggesting that liposuction should be performed as a hospital procedure only. The aim of this study was to determine prilocaine plasma levels and methemoglobinemia in patients after low- to average-volume liposuction for the purpose of defining the required postoperative surveillance period.
  
  
  METHODS
  In 25 patients undergoing liposuction involving less than 2,000 ml prilocaine levels and methemoglobinemia were measured over 4 h postoperatively. Liposuction was conducted after the tumescent technique using a 0.05% hypotonic prilocaine solution with epinephrine.
  
  
  RESULTS
  The average prilocaine dose was 6.8 + 0.8 mg/kg, with a maximum dose of 15 mg/kg. The peak prilocaine plasma level of 0.34 mug/ml occurred 3 h after the infiltration. The mean methemoglobinemia at this time point was 0.65%. Only one patient demonstrated a slightly elevated methemoglobin level of 1.4%, but lacked any clinical signs of methemoglobinemia. The prilocaine recovery in the aspirate averaged 36 +/- 4%, indicating that a large amount is removed by suctioning.
  
  
  CONCLUSIONS
  The patients did not experience high plasma levels of prilocaine or methemoglobinemia undergoing liposuction involving less than 2,000 ml using a 0.05% hypotonic prilocaine solution. The authors therefore conclude that this procedure can be performed safely with a monitoring period of 12 h.
authors.affiliation: Department of General Surgery, University of Rostock, Schillingallee 35, 18057 Rostock, Germany. niclindenblatt@hotmail.com
authors.forename: N
authors.initials: N
authors.lastname: Lindenblatt
authors.forename: L
authors.initials: L
authors.lastname: Belusa
authors.forename: B
authors.initials: B
authors.lastname: Tiefenbach
authors.forename: W
authors.initials: W
authors.lastname: Schareck
authors.forename: R R
authors.initials: RR
authors.lastname: Olbrisch
mesh_terms: D000328:Adult; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000097:blood*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D015187:Lipectomy / Q000379:methods*; D008297:Male; D008708:Methemoglobinemia / Q000097:blood*; D008875:Middle Aged; D011182:Postoperative Care; D011300:Preoperative Care; D011318:Prilocaine / Q000008:administration & dosage / Q000097:blood*
chemical_list: D000779:Anesthetics, Local; D011318:Prilocaine