[Use of tremonorm in treatment of Parkinson's disease: outpatient experience of Moscow Municipal Health Care Service].
The efficacy of domestic drug tremonorm (levadopa-carbidopa) for Parkinson's disease (PD) treatment was studied. The treatment was conducted in neurological outpatient departments in several Moscow administrative regions and was administered to 142 PD patients, 15 being assigned to this drug for the first time and 127 being previously treated with other medications containing levadopa/carbidopa. A minimal effective dose (up to 500 mg) was selected for each patient and was not changed during 2 months. For patients previously switched to levadopa, the change for tremonorm has been done during 1 day if the dose of levadopa did not exceed 500 mg, and during 2 months in case a patient received over 500 mg per day. Modified Hoehn&Yahr scale, UPDRS, MMSE, PDQ-39 and other scales were used in complex evaluation of the disease stage. Positive effect of tremonorm was detected for 94 patients (66.2%), all of them continued tremonorm therapy after the end of the study. The most frequent side-effects proved to be dyspeptic symptoms. Tremonorm caused statistically significant positive changes in patient's movement scaled by UPDRS and the QL indexes in all PDQ-39 subscales. Positive changes in movement activity were accompanied by decrease of bradykinesia, tremor, better walking, writing and every day activity of PD patients. A change of nacom for tremonorm did not result in significant alteration of symptoms and Quality of Life indexes that suggest similar influence of these drugs on PD symptomatology. At the same time, a substantially lower price of tremonorm allows reducing of treatment costs.
Boĭko
A N
AN
Batysheva
T T
TT
Chikina
E S
ES
Artemova
I Iu
IIu
Vdovichenko
T V
TV
Ganzhula
P A
PA
Ismailov
A M
AM
Lisenker
L N
LN
Obydenova
N A
NA
Rotor
L D
LD
Khozova
A A
AA
Vinetskiĭ
Ia Ia
IaIa
D002230:Carbidopa / Q000008:administration & dosage* / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use; D003627:Data Interpretation, Statistical; D004338:Drug Combinations; D004415:Dyspepsia / Q000139:chemically induced; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage* / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use; D008609:Mental Status Schedule; D009031:Moscow; D010045:Outpatients; D010300:Parkinson Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000191:economics; D011788:Quality of Life; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome
D004338:Drug Combinations; D007980:Levodopa; D002230:Carbidopa