title: Requirement of MgtC for Brucella suis intramacrophage growth: a potential mechanism shared by Salmonella enterica and Mycobacterium tuberculosis for adaptation to a low-Mg2+ environment.
abstract: A Brucella suis mgtC mutant is defective for growth within macrophages and in low-Mg(2+) medium. These phenotypes are strikingly similar to those observed with mgtC mutants from Salmonella enterica and Mycobacterium tuberculosis, two other pathogens that proliferate within phagosomes. MgtC appears as a remarkable virulence factor that would have been acquired by distantly related intracellular pathogens to contribute to the adaptation to a low-Mg(2+) environment in the phagosome.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, Unité 431, UFR de Médecine, CS 83021, Avenue J.F. Kennedy, 30908 NIMES Cedex 02, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Lavigne
authors.forename: David
authors.initials: D
authors.lastname: O'callaghan
authors.forename: Anne-Béatrice
authors.initials: AB
authors.lastname: Blanc-Potard
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D041021:Brucella suis / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism / Q000472:pathogenicity; D027682:Cation Transport Proteins / Q000235:genetics / Q000378:metabolism*; D002460:Cell Line; D003470:Culture Media; D015964:Gene Expression Regulation, Bacterial; D008264:Macrophages / Q000382:microbiology*; D008274:Magnesium / Q000378:metabolism*; D051379:Mice; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000254:growth & development; D019779:Salmonella enterica / Q000254:growth & development; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; D027682:Cation Transport Proteins; D003470:Culture Media; C093586:MgtC protein, Salmonella typhimurium; D008274:Magnesium