title: Life-threatening allergic bronchopulmonary aspergillosis in a well child with cystic fibrosis.
abstract: Allergic bronchopulmonary aspergillosis (ABPA) is an uncommon condition which may complicate asthma and cystic fibrosis; it is seldom considered life-threatening. We report a well 8-year-old boy with cystic fibrosis and normal lung function who progressed to respiratory failure over several days, attributable to ABPA. He recovered with non-invasive ventilation and oral corticosteroid and antifungal medications, regaining normal lung function within 2 months. To our knowledge, such an acute severe presentation of ABPA in a previously well child has not been reported before.
authors.affiliation: University of Sydney, Sydney, NSW.
authors.forename: Emma
authors.initials: E
authors.lastname: Skowronski
authors.forename: Dominic A
authors.initials: DA
authors.lastname: Fitzgerald
mesh_terms: D000908:Antibodies, Fungal / Q000097:blood; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D001232:Aspergillus fumigatus / Q000276:immunology; D002648:Child; D003550:Cystic Fibrosis / Q000150:complications*; D005541:Forced Expiratory Volume; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D012131:Respiratory Insufficiency / Q000382:microbiology*
chemical_list: D000908:Antibodies, Fungal; D007073:Immunoglobulin E