title: Microsatellite polymorphisms in the epidermal growth factor receptor (EGFR) gene and the transforming growth factor-alpha (TGFA) gene and risk of oral cancer in Puerto Rico.
abstract: OBJECTIVE
  Risks of oral cancer related to a CA microsatellite repeat polymorphism in intron 1 of the epidermal growth factor receptor (EGFR) gene and a TaqI polymorphism in the transforming growth factor-alpha (TGFA) gene were evaluated in a population-based case-control study consisting of 157 cases and 149 controls recruited in Puerto Rico.
  
  
  RESULTS
  Carriers of > or = 16 CA repeats in EGFR showed a 1.9-fold increased risk for oral cancer (OR=1.9, 95% CI=1.0-3.5). Risks also tended to increase with decreasing number of alleles with > or = 16 CA repeats (P for trend=0.06). Our data suggested a non-significant reduction in risk for subjects heterozygous for the TGFA polymorphism (OR=0.6, 95% CI=0.2-1.3).
  
  
  CONCLUSIONS
  The EGFR-associated risk appeared to be independent of tobacco and alcohol use and may be restricted primarily to subjects who consumed low amounts of fresh fruits and vegetables (OR=5.9, 95%CI: 2.3-15.2). These data implicate dietary and molecular targets for oral cancer prevention.
authors.affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, Cancer Research Institute, SNUCM, Seoul, Korea. dhkang@snu.ac.kr
authors.forename: Daehee
authors.initials: D
authors.lastname: Kang
authors.forename: Gloria
authors.initials: G
authors.lastname: Gridley
authors.forename: Wen-Yi
authors.initials: WY
authors.lastname: Huang
authors.forename: Lawrence S
authors.initials: LS
authors.lastname: Engel
authors.forename: Deborah M
authors.initials: DM
authors.lastname: Winn
authors.forename: Linda M
authors.initials: LM
authors.lastname: Brown
authors.forename: Eleuterio
authors.initials: E
authors.lastname: Bravo-Otero
authors.forename: Tianxia
authors.initials: T
authors.lastname: Wu
authors.forename: Scott R
authors.initials: SR
authors.lastname: Diehl
authors.forename: Richard B
authors.initials: RB
authors.lastname: Hayes
mesh_terms: D000328:Adult; D000368:Aged; D000434:Alcoholic Beverages; D016022:Case-Control Studies; D005260:Female; D005638:Fruit; D018773:Genes, erbB-1 / Q000235:genetics*; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D011647:Puerto Rico / Q000453:epidemiology; D012307:Risk Factors; D012907:Smoking; D016211:Transforming Growth Factor alpha / Q000235:genetics*; D014675:Vegetables
chemical_list: D016211:Transforming Growth Factor alpha