Differential antibody responses to Plasmodium falciparum glycosylphosphatidylinositol anchors in patients with cerebral and mild malaria.
Glycosylphosphatidylinositol (GPI) membrane anchors of Plasmodium falciparum surface proteins are thought to be important factors contributing to malaria pathogenesis, and anti-GPI antibodies have been suggested to provide protection by neutralizing the toxic activity of GPIs. In this study, IgG responses against P. falciparum GPIs and a baculovirus recombinant MSP1p19 antigen were evaluated in two distinct groups of 70 patients each, who were hospitalized with malaria. Anti-GPI IgGs were significantly lower in patients hospitalized with confirmed cerebral malaria compared to those with mild malaria (P < 0.01) but did not discriminate for fatal outcome. In contrast, a specific marker of the anti-parasite immunity, as monitored by the anti-MSP1p19 IgG response, was similar in both cerebral and mild malaria individuals, although it was significantly lower in a subgroup with fatal outcomes. These results are consistent with a potential anti-toxin role for anti-GPI antibodies associated with protection against cerebral malaria.
Perraut
Ronald
R
Unité d'Immunologie, Institut Pasteur de Dakar, 36 Av. Pasteur, BP-220, Dakar, Senegal. perraut@pasteur.sn
Diatta
Bacary
B
Marrama
Laurence
L
Garraud
Olivier
O
Jambou
Ronan
R
Longacre
Shirley
S
Krishnegowda
Gowdahalli
G
Dieye
Alioune
A
Gowda
D Channe
DC
D000293:Adolescent; D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D017261:Glycosylphosphatidylinositols / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D016779:Malaria, Cerebral / Q000276:immunology* / Q000469:parasitology; D016778:Malaria, Falciparum / Q000276:immunology* / Q000469:parasitology; D020066:Merozoite Surface Protein 1 / Q000276:immunology; D008875:Middle Aged; D010963:Plasmodium falciparum / Q000276:immunology* / Q000472:pathogenicity
D000913:Antibodies, Protozoan; D017261:Glycosylphosphatidylinositols; D007074:Immunoglobulin G; D020066:Merozoite Surface Protein 1