title: Therapy, outcome and analysis of c-kit expression in patients with extrapulmonary small cell carcinoma.
abstract: In this study, we aimed to investigate the clinicopathological characteristics with special emphasis on c-kit expression and the treatment results of patients with extrapulmonary small cell carcinoma (EPSCC). The medical records of the patients with EPSCC were reviewed, and the data regarding patient and tumour characteristics, treatment and clinical outcome were retrieved and analysed. A total of 28 patients with the diagnosis of EPSCC were identified. There were 19 males and 9 females, with a mean age of 56.5 years. Patients with limited disease (LD) (n = 13) were treated with surgery, chemotherapy (CT) and radiotherapy with different sequences. Patients with extensive disease (ED) (n = 15) were mainly treated with combination CT. The median overall survival was 14.5 months in patients with LD compared to 11 months in those with ED (p = 0.029). Ten patients (36%) showed c-kit overexpression. There was no significant difference between the survival of c-kit-positive and c-kit-negative patients (p = 0.367). In conclusion, our study demonstrates that the prognosis of EPSCC is poor despite currently available treatments. C-kit may be considered as a potential target for novel therapeutical approaches.
authors.affiliation: Uludag University Medical School, Bursa, Turkey. ekurt@uludag.edu.tr
authors.forename: E
authors.initials: E
authors.lastname: Kurt
authors.forename: C
authors.initials: C
authors.lastname: Sezgin
authors.forename: T
authors.initials: T
authors.lastname: Evrensel
authors.forename: U
authors.initials: U
authors.lastname: Yalcinkaya
authors.forename: O
authors.initials: O
authors.lastname: Kanat
authors.forename: A
authors.initials: A
authors.lastname: Veral
authors.forename: M
authors.initials: M
authors.lastname: Demiray
authors.forename: M
authors.initials: M
authors.lastname: Arslan
authors.forename: B
authors.initials: B
authors.lastname: Karabulut
authors.forename: I
authors.initials: I
authors.lastname: Ercan
authors.forename: E
authors.initials: E
authors.lastname: Goker
authors.forename: O
authors.initials: O
authors.lastname: Manavoglu
mesh_terms: D000328:Adult; D000368:Aged; D018288:Carcinoma, Small Cell / Q000235:genetics* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000235:genetics* / Q000628:therapy; D015870:Gene Expression; D006801:Humans; D008297:Male; D008875:Middle Aged; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics*; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D019009:Proto-Oncogene Proteins c-kit