[Evaluation of therapeutic project on acute tetramethylene disulphotetramine poisoning and effect on intelligence in children].
OBJECTIVE
To evaluate four therapeutic measures on acute tetramethylene disulphotetramine (TETS) poisoning and the effects of it on intelligence of children.


METHODS
All 86 patients of acute TETS poisoning were randomly divided into 4 groups (the control group, sodium valproate group, sodium dimercaptopropane sulfonate group and the hemoperfusion group). The therapeutic effects were observed after the arranged treatment was administrated. According to age, residence, sex, education and domestic economy, 30 children were matched by 1:1 with children of TETS poisoning.


RESULTS
The termination time of seizure, doses of diazepam, mental symptoms and the continual time of mental symptoms were not significantly different among these three groups. After hemoperfusion, the seizure of patients was terminated or the frequency was obviously decreased, but the level of TETS in blood was not reduced. The average scores of full intelligence quotient (FIQ), the verbal intelligence quotient (VIQ) and the performance intelligence quotient (PIQ) of children in poisoning group were 9.1, 8.8 and 7.7 less than the controls. The average scores of FIQ of children with bad state were 15 less than the controls.


CONCLUSIONS
Therapeutic effects of sodium valproate and sodium dimercaptopropane sulfonate on acute TETS poisoning should be not better than using diazepam and sodium phenobarbital. Therapeutic effects of hemoperfusion on TETS poisoning is good. TETS poisoning should have a great influence on intelligence of children.
Bai
Hong
H
National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Zhang
Shou-lin
SL
Zhang
Hong-shun
HS
Ji
Jing-tang
JT
Ma
Pei-bin
PB
Wang
Hai-Shi
HS
Bai
Yun-wang
YW
Zhou
Xiao-rong
XR
Ding
Mao-bo
MB
Lu
Xi-rong
XR
Sun
Cheng-ye
CY
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D000931:Antidotes / Q000627:therapeutic use; D001952:Bridged-Ring Compounds / Q000506:poisoning*; D002648:Child; D005260:Female; D006464:Hemoperfusion / Q000379:methods; D006801:Humans; D007360:Intelligence / Q000187:drug effects*; D007361:Intelligence Tests; D008297:Male; D011041:Poisoning / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D012640:Seizures / Q000209:etiology / Q000517:prevention & control; D016896:Treatment Outcome; D014494:Unithiol / Q000627:therapeutic use; D014635:Valproic Acid / Q000627:therapeutic use; D055815:Young Adult
D000927:Anticonvulsants; D000931:Antidotes; D001952:Bridged-Ring Compounds; D014494:Unithiol; D014635:Valproic Acid; C010349:tetramethylenedisulfotetramine