title: Anorectic and behavioural effects of chronic Cissampelos sympodialis treatment in female and male rats.
abstract: Male and female rats were treated daily for 13 weeks with an ethanol extract of Cissampelos sympodialis leaves (9, 45 and 225 mg[sol ]kg). The food consumption, body weight and behavioural effects in the open-field test were evaluated by weekly monitoring. The results showed that the extract chronic treatment in female rats (45 and 225 mg[sol ]kg) reduced significantly the food intake and the body weight, and produced several alterations in the open-field test. These findings indicate that repeated oral administration of the extract may produce a sex-dependent difference in anoretic and behavioural effects.
authors.affiliation: Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba. Caixa Postal, João Pessoa, PB, Brazil. reinaldo@itf.ufpb.br
authors.forename: R N
authors.initials: RN
authors.lastname: Almeida
authors.forename: M F F
authors.initials: MF
authors.lastname: Melo-Diniz
authors.forename: I A
authors.initials: IA
authors.lastname: Medeiros
authors.forename: L J
authors.initials: LJ
authors.lastname: Quintans-Júnior
authors.forename: D S
authors.initials: DS
authors.lastname: Navarro
authors.forename: A C G M
authors.initials: AC
authors.lastname: Falcão
authors.forename: J C
authors.initials: JC
authors.lastname: Duarte
authors.forename: J M
authors.initials: JM
authors.lastname: Barbosa-Filho
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects; D031606:Cissampelos; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004435:Eating / Q000187:drug effects; D005260:Female; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000928:Antidepressive Agents; D010936:Plant Extracts