Synthesis of poison-frog alkaloids 237D, 207A, and two congeners of 235B' for evaluation to inhibitory effect of nicotinic acetylcholine receptors.
Enantioselective synthesis of the poison-frog alkaloids 237D, 207A, and two congeners of 235B' has been achieved. The absolute stereochemistry of 237D was determined to be 5S, 8S, 9R by the present synthesis.
Toyooka
Naoki
N
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugatani, Toyama 930-0194, Japan. toyooka@ms.toyama-mpu.ac.jp
Kawasaki
Masashi
M
Nemoto
Hideo
H
D000470:Alkaloids / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D001001:Anura; D004353:Drug Evaluation, Preclinical / Q000379:methods; D018733:Nicotinic Antagonists / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D011978:Receptors, Nicotinic / Q000502:physiology*
D000470:Alkaloids; D018733:Nicotinic Antagonists; D011978:Receptors, Nicotinic