title: Subchronic treatment with imipramine ameliorates the decreased number in neuropeptide Y-positive cells in the hippocampus of learned helplessness rats.
abstract: Learned helplessness, but not immobilization stress, decreased the numbers of neuropeptide Y (NPY)-positive cells (interneuron), but not calcitonin gene-related peptide (CGRP)-positive cells (mossy cell), in the hilus of the hippocampus. Subchronic treatment of learned helplessness rats, but not naive rats, with imipramine ameliorated the decrease in the number of NPY-positive cells. Therefore, NPY-positive cells in the hippocampus may contribute to depression.
authors.affiliation: Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Japan.
authors.forename: Hisahito
authors.initials: H
authors.lastname: Ishida
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Shirayama
authors.forename: Masaaki
authors.initials: M
authors.lastname: Iwata
authors.forename: Ryuzou
authors.initials: R
authors.lastname: Kawahara
mesh_terms: D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage*; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism; D002452:Cell Count; D004334:Drug Administration Schedule; D006380:Helplessness, Learned; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D007099:Imipramine / Q000008:administration & dosage*; D007395:Interneurons / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009478:Neuropeptide Y / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012149:Restraint, Physical / Q000502:physiology
chemical_list: D000929:Antidepressive Agents, Tricyclic; D009478:Neuropeptide Y; D015740:Calcitonin Gene-Related Peptide; D007099:Imipramine