title: Beneficial effects of vitamin C and vitamin E on reserpine-induced oral dyskinesia in rats: critical role of striatal catalase activity.
abstract: Oral dyskinesias are implicated in a series of neuropathologies and have been associated to an increase in oxidative stress. Several antioxidants, including vitamin E, decrease reserpine-induced oral dyskinesia (OD) in rodents and we have described a protective role of striatal catalase against the development of OD. The aim of this study was to verify the effects of vitamin C alone or in combination with vitamin E on reserpine-induced OD as well as to determine a possible role of catalase in the antidyskinetic property of these vitamins. Different doses of vitamin C attenuated reserpine-induced increase in OD. A similar treatment with an effective dose of vitamin C concomitant to an effective dose of vitamin E potentiated the antidyskinetic effect of both vitamins when administered alone. The administration of these vitamins alone produced an increase in striatal catalase activity that likewise was potentiated by their combined administration. In addition, the antidyskinetic property of vitamin E and vitamin C was abolished by a concomitant treatment with the catalase inhibitor aminotriazole. These results indicate a beneficial effect of these vitamins and reinforce the critical role of striatal catalase against the development of oral dyskinesias.
authors.affiliation: Department of Pharmacology, Escola Paulista de Medicina/UNIFESP, São Paulo, Brazil.
authors.forename: Rulian Ricardo
authors.initials: RR
authors.lastname: Faria
authors.forename: Vanessa Costhek
authors.initials: VC
authors.lastname: Abílio
authors.forename: Christian
authors.initials: C
authors.lastname: Grassl
authors.forename: Cibele Cristina
authors.initials: CC
authors.lastname: Chinen
authors.forename: Luciana Takahashi Ribeiro
authors.initials: LT
authors.lastname: Negrão
authors.forename: Juliana Pedroso Moraes Vilela
authors.initials: JP
authors.lastname: de Castro
authors.forename: Daniela Fukue
authors.initials: DF
authors.lastname: Fukushiro
authors.forename: Marcelo Scarpari Dutra
authors.initials: MS
authors.lastname: Rodrigues
authors.forename: Patricia Helena Zanier
authors.initials: PH
authors.lastname: Gomes
authors.forename: Sibele
authors.initials: S
authors.lastname: Registro
authors.forename: Rita de Cassia
authors.initials: Rde C
authors.lastname: de Carvalho
authors.forename: Vania
authors.initials: V
authors.lastname: D'Almeida
authors.forename: Regina Helena
authors.initials: RH
authors.lastname: Silva
authors.forename: Rosana de Alencar
authors.initials: Rde A
authors.lastname: Ribeiro
authors.forename: Roberto
authors.initials: R
authors.lastname: Frussa-Filho
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D002374:Catalase / Q000378:metabolism*; D003342:Corpus Striatum / Q000187:drug effects / Q000201:enzymology*; D004409:Dyskinesia, Drug-Induced / Q000201:enzymology* / Q000517:prevention & control*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012110:Reserpine / Q000633:toxicity; D014810:Vitamin E / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D014810:Vitamin E; D012110:Reserpine; D002374:Catalase; D001205:Ascorbic Acid