Participation of adenosine system in the ketamine-induced motor activity in mice.
The influence of adenosine receptor ligands on ketamine-induced locomotor activity was studied in mice. Ketamine-induced hyperactivity (10 mg/kg) was significantly and dose-dependently attenuated by CGS 21680 (selective A(2A) receptor agonist), and NECA (A1/A2 adenosine receptor agonist), but not by CPA (cyclopentyladenosine, selective A1 adenosine receptor agonist). Motor activity produced by subthreshold dose (2.5 mg/kg) of ketamine was significantly increased by DMPX (selective A1 receptor antagonist) and caffeine (A1/A2 adenosine receptor antagonist), but not by DPCPX (selective A1 adenosine receptor antagonist). These results suggest that adenosinergic system is involved in ketamine-induced motor activity and seem to indicate a predominant role of A(2A) adenosine receptor in this effect.
Mandryk
Marcin
M
Department of Pharmacodynamics, Medical University, Staszica 4, PL 20-081 Lublin, Poland.
Fidecka
Sylwia
S
Poleszak
Ewa
E
Malec
Danuta
D
D000818:Animals; D004347:Drug Interactions; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D058906:Purinergic P1 Receptor Agonists; D058915:Purinergic P1 Receptor Antagonists; D018047:Receptors, Purinergic P1 / Q000187:drug effects
D058906:Purinergic P1 Receptor Agonists; D058915:Purinergic P1 Receptor Antagonists; D018047:Receptors, Purinergic P1; D007649:Ketamine