Reflections on the discovery and significance of estrogen receptor beta.
We have known for many years that estrogen is more than the female hormone. It is essential in the male gonads, and in both sexes, estrogen has functions in the skeleton and central nervous system, on behavior, and in the cardiovascular and immune systems. An important aspect of the discovery of estrogen receptor (ER) beta is that the diverse functions of estrogen can now be divided into those mediated by ERalpha and those mediated by ERbeta. Pharmacological exploitation of this division of the labors of estrogen is facilitated by the ligand-binding specificity and selective tissue distribution of the two ERs. Because the ligand binding domains of ERalpha and ERbeta are significantly different from each other, selective ligands can be (and have been) developed to target the estrogenic pathway that is malfunctioning, without interfering with the other estrogen-regulated pathways. Because of the absence of ERbeta from the adult pituitary and endometrium, ERbeta agonists can be used to target ERbeta with no risk of adverse effects from chemical castration and uterine cancer. Some of the diseases in which there is hope that ERbeta agonists will be of benefit are prostate cancer, autoimmune diseases, colon cancer, malignancies of the immune system, and neurodegeneration.
Koehler
Konrad F
KF
Department of BioSciences and Medical Nutrition, Karolinska Institutet, Novum, SE-141 57 Huddinge, Sweden.
Helguero
Luisa A
LA
Haldosén
Lars-Arne
LA
Warner
Margaret
M
Gustafsson
Jan-Ake
JA
D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology; D001940:Breast / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism; D047628:Estrogen Receptor alpha / Q000378:metabolism; D047629:Estrogen Receptor beta / Q000819:agonists / Q000737:chemistry* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008024:Ligands; D008297:Male; D051379:Mice; D008958:Models, Molecular; D010080:Oxazoles / Q000494:pharmacology; D011467:Prostate / Q000378:metabolism; D014599:Uterus / Q000378:metabolism
D018931:Antineoplastic Agents, Hormonal; C478102:ERB 041; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D008024:Ligands; D010080:Oxazoles; D004958:Estradiol