[Preparation and characterization of indomethacin/poly(N-isopropylacrylamide)-beta-cyclodextrin complex with temperature-sensitivity].
OBJECTIVE
To synthesize poly(N-isopropylacrylamide)/cyclodextrin conjugate (PNIPA-beta-CD) as thermosensitive drug carrier, incorporate indomethacin into the conjugate and evaluate the drug release from the carrier in vitro.


METHODS
PNIPA-beta-CD was synthesized by introducing carboxyl terminated PNIPA into the primary hydroxy group of beta-CD. The obtained conjugate was characterized by FTIR, 1H NMR and DSC. The indomethacin/PNIPA-beta-CD complex was prepared by lyophilization. In vitro drug release from the complex was carried out at 25 degrees C and 37 degrees C respectively.


RESULTS
Thermosensitive PNIPA-beta-CD was synthesized successfully. The LCST is 35 degrees C, as measured by turbidity method. The drug release from indomethacin/PNIPA-beta-CD complex was slower at 37 degrees C than that at 25 degrees C.


CONCLUSIONS
Thermosensitive PNIPA-beta-CD with molecular inclusion capacity is a potential carrier for drug sustained release.
Xia
Yun
Y
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, China.
Qiu
Li-yan
LY
Jin
Yi
Y
D000180:Acrylic Resins / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry; D004337:Drug Carriers; D007213:Indomethacin / Q000008:administration & dosage* / Q000737:chemistry; D013696:Temperature; D047392:beta-Cyclodextrins / Q000737:chemistry*
D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D047392:beta-Cyclodextrins; C052970:poly-N-isopropylacrylamide; D007213:Indomethacin