title: Role of gravity in mammalian development: effects of hypergravity and/or microgravity on the development of skeletal muscles.
abstract: Effects of hindlimb suspension or exposure to 2-G between postnatal day 4 and month 3 and of 3-month recovery at 1-G environment on the characteristics of rat hindlimb muscles were studied. Pronounced growth inhibition was induced by unloading, but not by 2-G loading. It is suggested that the development and/or differentiation of soleus muscle fibers are closely associated with gravitational loading. The data indicated that gravitational unloading during postnatal development inhibits the myonuclear accretion in accordance with subnormal numbers of both mitotic active and quiescent satellite cells. Even though the fiber formation and longitudinal fiber growth were not influenced, cross-sectional growth of muscle fibers was also inhibited in association with lesser myonuclear domain and DNA content per unit volume of myonucleus. Unloading-related inhibition was generally normalized following the recovery.
authors.affiliation: Sch. Health Sport Sci, Osaka Univ.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Ohira
authors.forename: Fuminori
authors.initials: F
authors.lastname: Kawano
authors.forename: Katsumasa
authors.initials: K
authors.lastname: Goto
authors.forename: Xiao Dong
authors.initials: XD
authors.lastname: Wang
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Takeno
authors.forename: Akihiko
authors.initials: A
authors.lastname: Ishihara
mesh_terms: D000818:Animals; D000843:Ankle Joint / Q000502:physiology; D002498:Centrifugation; D006112:Gravitation; D019417:Hindlimb Suspension; D018471:Hypergravity; D018656:Muscle Fibers, Fast-Twitch / Q000502:physiology; D018657:Muscle Fibers, Slow-Twitch / Q000502:physiology; D018482:Muscle, Skeletal / Q000254:growth & development / Q000502:physiology*; D018995:Myosin Heavy Chains / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D018474:Weightlessness Simulation
chemical_list: D018995:Myosin Heavy Chains