[Chemical constituents from the seeds of Annona squamosa].
OBJECTIVE
To study the antitumor active constituents of the seeds from Annona squamosa L. (Annonaceae).


METHODS
Various chromatographic techniques were used to isolate and purify the constituents. Their physico-chemical properties and spectral data were determined to elucidate the structures.


RESULTS
Eleven compounds were isolated and identified as annonaceous acetogenins: squamocenin (1), annotemoyin-2 (2), reticulatain-2 (3), squamocin-I (4), squamocin-B (5), squamocin (6), motrilin (7), squamostatin-D (8), squamostatin-E (9), cherimolin-1 (10), cherimolin-2 (11) from the ethyl alcohol extract of A. squamosa L.


CONCLUSIONS
Squamocenin (1) is a new acetogenin. Annotemoyin-2 (2) and reticulatain-2 (3) were isolated from this plant for the first time.
Yu
Jing-guang
JG
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China. yujingguang@163.com
Luo
Xiu-zhen
XZ
Sun
Lan
L
Li
De-yu
DY
Huang
Wen-hua
WH
Liu
Chun-yu
CY
D031041:Annona / Q000737:chemistry*; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification; D008968:Molecular Conformation; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry
D005663:Furans; D007783:Lactones; C509387:annotemoyin-2; C509388:reticulatain-2; C509386:squamocenin