title: Prognosis of patients with acute myeloid leukaemia admitted to intensive care.
abstract: This retrospective study assessed the prognostic factors associated with early and long-term outcome in consecutive patients with acute myeloid leukaemia (AML) admitted to the intensive care unit (ICU) over a 9-year period. A total of 83 patients were studied (age 48 +/- 16 years), among whom 60% were neutropenic on admission. For 68%, admission occurred within the first month following diagnosis of AML. The main reason for ICU admission was an acute respiratory disease in 82% of cases. Mechanical ventilation (MV) was required in 57% of patients. In-ICU mortality was 34%. Among patients discharged alive from ICU, 49% died within a year after discharge. Factors significantly associated with in-ICU death in multivariate analysis were simplified acute physiology score II and need for invasive MV (IMV). Age, performance status, AML3 subtype and complete remission were significantly associated with 1-year survival. Patients with acute respiratory failure initially supported with non-invasive MV had significantly better ICU outcome than patients initially supported with IMV. In conclusion, ICU admission is justified for selected patients with AML. The ICU mortality rate is highly predictable by the acute illness severity score. A 1-year survival is predicted by haematological prognostic factors.
authors.affiliation: Department of Respiratory and Critical Care Medicine, Hopital Hotel-Dieu, 75004 Paris, France. antoine.rabbat@htd.ap-hop-paris.fr
authors.forename: Antoine
authors.initials: A
authors.lastname: Rabbat
authors.forename: Driss
authors.initials: D
authors.lastname: Chaoui
authors.forename: David
authors.initials: D
authors.lastname: Montani
authors.forename: Ollivier
authors.initials: O
authors.lastname: Legrand
authors.forename: Aurélie
authors.initials: A
authors.lastname: Lefebvre
authors.forename: Bernard
authors.initials: B
authors.lastname: Rio
authors.forename: Nicolas
authors.initials: N
authors.lastname: Roche
authors.forename: Christine
authors.initials: C
authors.lastname: Lorut
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Marie
authors.forename: Gérard
authors.initials: G
authors.lastname: Huchon
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D003422:Critical Care; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D016896:Treatment Outcome