Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae.
A novel series of 6-O-arylpropargyl diazalides was synthesized and evaluated for their antibacterial activity. Members of this series exhibited potent activity against erythromycin-resistant respiratory tract pathogens.
Yong
Hong
H
Infectious Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60044, USA. hong.yong@abbott.com
Gu
Yu Gui
YG
Clark
Richard F
RF
Marron
Thomas
T
Ma
Zhenkun
Z
Soni
Niru
N
Stone
Gregory G
GG
Nilius
Angela M
AM
Marsh
Kennan
K
Djuric
Stevan W
SW
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D001682:Biological Availability; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D006207:Half-Life; D008826:Microbial Sensitivity Tests; D020005:Propanols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D013329:Structure-Activity Relationship; D015645:Tylosin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D020005:Propanols; D015645:Tylosin