The JNK interacting protein JIP-1 and insulin like growth factor II genes are co-expressed in human embryonic tumours.
JNK interacting protein 1 (JIP-1) is a pivotal scaffolding protein in the JNK signalling pathway. It is believed to play a role in the mediation of mitogenic messages from the plasma membrane to the cell interior. Recent evidence suggests that the JIP-1 gene is co-regulated with the insulin like growth factor II (IGF II) gene, thereby contributing to the growth-promoting effects of this potent growth factor. In this study, fourteen embryonic tumours were examined for the expression of JIP-1 and IGF II. It was found that, irrespective of histological type and expression level, the two genes showed a high degree of co-variation in the sense that high IGF II expression was followed by high expression of JIP-1. This finding further supports the notion that JIP-1 and IGF II act in concert to enhance cell proliferation.
Engström
Wilhelm
W
Division of Pathology, Pharmacology and Toxicology, Department of Biomedical Sciences and Veterinary Public Health, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden. wilhelm.engstrom@bvf.slu.se
Rising
Anna
A
Grip
Stefan
S
D048868:Adaptor Proteins, Signal Transducing / Q000096:biosynthesis* / Q000235:genetics; D015152:Blotting, Northern; D018236:Carcinoma, Embryonal / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D011061:Poly A / Q000378:metabolism; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism; D013736:Testicular Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology
D048868:Adaptor Proteins, Signal Transducing; C490666:MAPK8IP1 protein, human; D012334:RNA, Neoplasm; D011061:Poly A; D007335:Insulin-Like Growth Factor II