[Is antenatal corticosteroid administration associated with increased acid gastroesophageal reflux in preterm neonates?].
OBJECTIVE
Preliminary assessment of the incidence of acid gastroesophageal reflux in preterm neonates with and without antenatal administration of steroids.


METHODS
Analysis of 96 neonates born before 34 weeks of pregnancy was undertaken. The patients were divided into two groups: I - those who received antenatal corticosteroids n=22; II - those who received no antenatal corticosteroids n=74. All patients had 24-hour pH-metry and basing on the result of this examination we diagnosed or excluded acid gastroesophageal reflux.


RESULTS
In group I gastroesophageal reflux was diagnosed in 9/22 neonates (40.9%), in group II in 12/72 (16.2%), odds ratio=3.58.


CONCLUSIONS
The frequency of acid gastroesophageal reflux is higher in preterm infants who received antenatal corticosteroids.
Sadowska-Krawczenko
Iwona
I
Oddział Noworodków, Wcześniaków i Intensywnej Terapii Noworodka, SPZOZ Wojewódzkiego Szpitala im. J. Biziela, Ujejeskiego 75, Bygdoszcz, Poland. iesadowska@poczta.onet.pl
Czerwionka-Szaflarska
Mieczyslawa
M
Korbal
Piotr
P
D001623:Betamethasone / Q000009:adverse effects; D003907:Dexamethasone / Q000009:adverse effects; D005260:Female; D005764:Gastroesophageal Reflux / Q000139:chemically induced*; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000139:chemically induced*; D008297:Male; D008431:Maternal-Fetal Exchange; D007752:Obstetric Labor, Premature / Q000188:drug therapy; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced*
D005938:Glucocorticoids; D003907:Dexamethasone; D001623:Betamethasone