Prevalence of derepressed ampC mutants and extended-spectrum beta-lactamase producers among clinical isolates of Citrobacter freundii, Enterobacter spp., and Serratia marcescens in Korea: dissemination of CTX-M-3, TEM-52, and SHV-12.
The resistance mechanism of extended-spectrum cephalosporins in clinical isolates of Citrobacter freundii, Enterobacter spp., and Serratia marcescens was studied. Of 152 isolates, 45 isolates (29.6%) were derepressed AmpC mutants and 39 isolates (25.7%) produced extended-spectrum beta-lactamase (ESBLs). The most prevalent ESBLs were CTX-M enzymes, followed by TEM-52 and SHV-12.
Kim
Jungmin
J
Department of Microbiology, Kyungpook University School of Medicine, Daegu, Korea. minkim@dankook.ac.kr
Lim
Yu-Mi
YM
D001426:Bacterial Proteins / Q000235:genetics*; D001483:Base Sequence; D002511:Cephalosporins / Q000494:pharmacology; D002954:Citrobacter / Q000145:classification / Q000201:enzymology / Q000235:genetics* / Q000302:isolation & purification; D017931:DNA Primers; D004754:Enterobacter / Q000145:classification / Q000201:enzymology / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007723:Korea; D008826:Microbial Sensitivity Tests; D012706:Serratia marcescens / Q000145:classification / Q000201:enzymology / Q000235:genetics* / Q000302:isolation & purification; D001618:beta-Lactamases / Q000235:genetics*
D001426:Bacterial Proteins; D002511:Cephalosporins; D017931:DNA Primers; C048795:AmpC beta-lactamases; D001618:beta-Lactamases