title: Full genome sequence of peste des petits ruminants virus, a member of the Morbillivirus genus.
abstract: Peste des petits ruminants virus (PPRV) causes an acute febrile illness in small ruminant species, mostly sheep and goats. PPRV is a member of the Morbillivirus genus which includes measles, rinderpest (cattle plague), canine distemper, phocine distemper and the morbilliviruses found in whales, porpoises and dolphins. Full length genome sequences for these morbilliviruses are available and reverse genetic rescue systems have been developed for the viruses of terrestrial mammals, with the exception of PPRV. This paper presents the first published full length genome sequence for PPRV. The genome was found to be consistent with the rule-of-six and open reading frames (ORFs) were identified that encoded the eight proteins characteristic of morbilliviruses. At the nucleotide (nt) level, the full length genome of PPRV was most similar to that of rinderpest, the other ruminant morbillivirus. However, at the protein level five of the six structural proteins and the V protein showed a greater similarity to the dolphin morbillivirus (DMV) while only the C and L proteins showed a high relationship to rinderpest.
authors.affiliation: Pirbright Laboratory, Institute for Animal Health, Ash Road, Woking, Surrey GU24 ONF, UK.
authors.forename: Dalan
authors.initials: D
authors.lastname: Bailey
authors.forename: Ashley
authors.initials: A
authors.lastname: Banyard
authors.forename: Pradyot
authors.initials: P
authors.lastname: Dash
authors.forename: Aykut
authors.initials: A
authors.lastname: Ozkul
authors.forename: Tom
authors.initials: T
authors.lastname: Barrett
mesh_terms: D001483:Base Sequence; D016679:Genome, Viral; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D018107:Peste-des-petits-ruminants virus / Q000235:genetics*; D012302:Rinderpest virus / Q000235:genetics; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D014764:Viral Proteins / Q000235:genetics
chemical_list: D014764:Viral Proteins