A unique highly oxygenated pyrano[4,3-c][2]benzopyran-1,6-dione derivative with antioxidant and cytotoxic activities from the fungus Phellinus igniarius.
[structure: see text] A unique pyrano[4,3-c][2]benzopyran-1,6-dione derivative with an unprecedented carbon skeleton, phelligridin G (1), has been isolated from the fruiting body of the fungus Phellinus igniarius. Its structure was elucidated by detailed spectroscopic analysis. A possible biogenetic origin of 1 mediated by the fungal metabolite precursor 4-hydroxy-6-methyl-2-pyrone was postulated. Phelligridin G (1) showed antioxidant activity inhibiting rat liver microsomal lipid peroxidation and moderate selective cytotoxic activities against human cancer cell lines.
Wang
Ying
Y
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
Mo
Shun-Yan
SY
Wang
Su-Juan
SJ
Li
Shuai
S
Yang
Yong-Chun
YC
Shi
Jian-Gong
JG
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011124:Polyporaceae / Q000737:chemistry*; D051381:Rats
D000970:Antineoplastic Agents; D000975:Antioxidants; D001578:Benzopyrans; C507450:phelligridin G