title: Quantification of multiple sclerosis lesion load and brain tissue volumetry using multiparameter MRI: methodology and reproducibility.
abstract: Quantitative characterization of multiple sclerosis (MS) lesion load is of considerable interest to clinical follow-up studies. Based on fuzzy clustering of multiparameter magnetic resonance images, we have developed a computer-assisted system for volumetric quantification of brain tissue. Tests on patient data show that the system is very efficient, and volumetric measurements characterized are highly reproducible. The high reproducibility and efficiency offer the potential of routine laboratory and clinical use for quantification of MS lesion load.
authors.affiliation: Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232-2675, USA. zhaohua.ding@vanderbilt.edu
authors.forename: Zhaohua
authors.initials: Z
authors.lastname: Ding
authors.forename: Jana
authors.initials: J
authors.lastname: Preiningerova
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Cannistraci
authors.forename: Timothy L
authors.initials: TL
authors.lastname: Vollmer
authors.forename: John C
authors.initials: JC
authors.lastname: Gore
authors.forename: Adam W
authors.initials: AW
authors.lastname: Anderson
mesh_terms: D000465:Algorithms; D001921:Brain / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009103:Multiple Sclerosis / Q000473:pathology*; D015203:Reproducibility of Results