Cordycedipeptide A, a new cyclodipeptide from the culture liquid of Cordyceps sinensis (Berk.) Sacc.
A new cyclodipeptide named as cordycedipeptide A, a new natural compound and two known compound were isolated from the culture liquid of Cordyceps sinensis (BERK.) SACC. Their structures were elucidated as 3-acetamino-6-isobutyl-2,5-dioxopiperazine (1), 3-isopropyl-6-isobutyl-2,5-dioxopiperazine (2) and 3,6-di(4-hydroxy)benzyl-2,5-dioxopiperazine (3) by 1D and 2D-NMR techniques. The cytotoxic assay showed compound 1 had the cytotoxic activities to L-929, A375, and Hela.
Jia
Jing-Ming
JM
Department of Traditional Chinese Medicines, Shenyang Pharmaceutical University, Shenyang 110016, China.
Ma
Xiao-Chi
XC
Wu
Chun-Fu
CF
Wu
Li-Jun
LJ
Hu
Gao-sheng
GS
D032661:Cordyceps / Q000737:chemistry / Q000302:isolation & purification*; D003470:Culture Media / Q000737:chemistry / Q000302:isolation & purification*; D004151:Dipeptides / Q000737:chemistry* / Q000302:isolation & purification*; D006367:HeLa Cells; D006801:Humans
D003470:Culture Media; D004151:Dipeptides