[The role of peroxisome proliferator-activated receptor gamma in the pathogenesis of diabetes and atheromatosis].
The high risik of cardiovascular diseases in diabetes is connected with wide and premature atheromatosis. It is caused by systemic metabolic disorders like hyperglycaemia, insulin resistance, dyslipidaemia, endothelium dysfunction. This review will discuss the role of peroxisome proliferator-activated receptor gamma (PPARgamma) in the pathogenesis diabetes and atheromatosous injury of vessels. PPARgamma is a nuclear transcript factor with a very wide spectrum of biological activities. It influences important risik factors of atheromathosis, especially by patients with metabolic syndrome in diabetes type 2. Thiazolidinediones, which is activators PPARgamma, could be a turning-point in the treatment of diabetic angiopathy.
Gacka
Małgorzata
M
Katedra i Klinika Angiologii, Nadciśnienia, Tetniczego i Diabetologii Akademii Medycznej we Wrocławiu.
Adamiec
Rajmund
R
Dobosz
Tadeusz
T
Szymaniec
Stanisław
S
Bednarska-Chabowska
Dorota
D
D003324:Coronary Artery Disease / Q000378:metabolism* / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D047495:PPAR gamma / Q000378:metabolism*; D045162:Thiazolidinediones / Q000627:therapeutic use
D007004:Hypoglycemic Agents; D047495:PPAR gamma; D045162:Thiazolidinediones