title: Determination of splenomegaly by CT: is there a place for a single measurement?
abstract: OBJECTIVE
  Our objective was to determine if there is a single parameter that can be used as a marker of splenomegaly using CT.
  
  
  METHODS
  Splenic length, width, and thickness were measured in 249 CT scans and multidimensional indexes were obtained from the multiplication of these measurements. Volume was calculated by summing the volumes of multiple contiguous scans. The relationship of the spleen to the left liver lobe and inferior third of the left kidney was also evaluated. Linear equations were obtained to correlate each measurement to the splenic volume.
  
  
  RESULTS
  The unidimensional measurements with best correlation to volume were splenic length (r = 0.81, p < 0.01) and width (r = 0.804, p < 0.01). Correlation was better for the multidimensional indexes (r = 0.95, p < 0.01). Using a previously described upper limit of normality for splenic volume of 314.5 cm3 in the linear regression equation obtained, a maximum spleen length of 9.76 cm was the upper limit of normality. The relation of the lowest point of the spleen to the inferior third of the kidney also showed that if the spleen reached or extended below this portion of the kidney, it could be used as evidence of splenomegaly (p < 0.005), although it had a low sensitivity.
  
  
  CONCLUSIONS
  Splenic length and multidimensional indexes correlate well with splenic CT volume. A splenic length of 9.76 cm can be used to accurately diagnose splenomegaly and can replace multiple-measurement, time-consuming methods in the clinical routine.
authors.affiliation: Universidade Católica de Brasília-Campus I, Curso de Medicina, EPCT QS 7 Lote 1, Taguatinga, Distrito Federal, Brazil, 71966-700. alexandrebezerra@ig.com.br
authors.forename: Alexandre S
authors.initials: AS
authors.lastname: Bezerra
authors.forename: Giuseppe
authors.initials: G
authors.lastname: D'Ippolito
authors.forename: Salomão
authors.initials: S
authors.lastname: Faintuch
authors.forename: Jacob
authors.initials: J
authors.lastname: Szejnfeld
authors.forename: Muneeb
authors.initials: M
authors.lastname: Ahmed
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013163:Splenomegaly / Q000000981:diagnostic imaging* / Q000473:pathology; D036542:Tomography, Spiral Computed / Q000379:methods*