The 6-derivative of beta-cyclodextrin with succinic acid: a new chiral selector for CD-EKC.
6-O-Succinil-beta-cyclodextrin (CDsuc6) was synthesized with very good yield by one pot synthesis and characterized by NMR spectroscopy and ESI-MS. It was used as a chiral selector in capillary electrophoresis to resolve catecholamine racemates, namely norepinephrine, epinephrine, terbutaline and norphenilephrine. The CE experiments at pH 5.6 show very promising selector ability by 6-O-succinil-beta-cyclodextrin for the chiral recognition of all the catecholamines tested, while at pH 9.2, only racemic terbutaline was successfully separated.
Cucinotta
Vincenzo
V
Department of Chemical Sciences, University of Catania, Viale A.Doria 6, 95125 Catania, Italy. ecucinotta@unict.it
Giuffrida
Alessandro
A
Maccarrone
Giuseppe
G
Messina
Marianna
M
Puglisi
Antonino
A
Torrisi
Alberto
A
Vecchio
Graziella
G
D002845:Chromatography / Q000379:methods; D003505:Cyclodextrins / Q000032:analysis; D004563:Electrochemistry; D008968:Molecular Conformation; D019802:Succinic Acid / Q000032:analysis* / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000032:analysis* / Q000737:chemistry*
D003505:Cyclodextrins; D047392:beta-Cyclodextrins; D019802:Succinic Acid; C031215:betadex