Speculations on the role of the microtubule network in glucocorticoid receptor signaling.
The glucocorticoid receptor (GR) is an important player in the life of a cell. This is underlined by a cohort of protein and nucleic acid structures interacting with the GR. Among many issues surrounding GR activity that are under active investigation, the role of microtubules (MTs) is still unclear. This article aims to evaluate the ayes and noes in favor of microtubule importance and then form a hypothesis on their function in GR activity.
Dvorák
Z
Z
Institute of Medical Chemistry and Biochemistry, Medical Faculty, Palacky University Olomouc, Olomouc, Czech Republic. moulin@email.cz
Modrianský
M
M
Ulrichová
J
J
Maurel
P
P
D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D005786:Gene Expression Regulation; D005938:Glucocorticoids / Q000502:physiology; D006728:Hormones / Q000502:physiology; D006801:Humans; D008870:Microtubules / Q000502:physiology*; D008954:Models, Biological; D010766:Phosphorylation; D011965:Receptors, Glucocorticoid / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology
D005938:Glucocorticoids; D006728:Hormones; D011965:Receptors, Glucocorticoid; D014157:Transcription Factors