Effect of alcohol consumption on estimated glomerular filtration rate and creatinine clearance rate.
BACKGROUND
Moderate alcohol consumption is widely recognized as beneficial in the prevention of cardiovascular disease, yet the renal effects of alcohol intake are still controversial. The present study is designed to investigate the influence of alcohol consumption on calculated creatinine clearance rate (CCr) and glomerular filtration rate (GFR) in a Southern Taiwan Pai-Wan aboriginal community with a high prevalence of alcohol consumption.


METHODS
This is a cross-sectional community-based study. The 1466 aboriginal subjects, 40-95 years of age, are a stratified random subpopulation identified during an integrative health care programme. They were sampled for drinking patterns. The main outcome measurements were serum creatinine, estimated CCr and GFR.


RESULTS
Subjects with alcohol consumption had significantly higher levels of serum triglycerides, high-density lipoprotein cholesterol, uric acid, estimated CCr and GFR values than non-drinkers. Their blood pressure was also significantly higher. They had lower total cholesterol and low-density lipoprotein cholesterol concentrations. Increasing alcohol consumption was independently and significantly associated with a higher level of estimated CCr and GFR when analysed as both a categorical and continuous variable.


CONCLUSIONS
The present study shows that chronic alcohol consumption has a negative effect on blood pressure and lipid profile and stimulates the estimated GFR.
Chung
Fu-Mei
FM
Department of Clinical Research, Pingtung Christian Hospital, No. 60, Da-Lien Rd, Pingtung, 90000, Taiwan.
Yang
Yi-Hsin
YH
Shieh
Tien-Yu
TY
Shin
Shyi-Jang
SJ
Tsai
Jack C-R
JC
Lee
Yau-Jiunn
YJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking; D001794:Blood Pressure / Q000187:drug effects; D008076:Cholesterol, HDL / Q000378:metabolism; D008078:Cholesterol, LDL / Q000378:metabolism; D003404:Creatinine / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D012907:Smoking; D013624:Taiwan; D014280:Triglycerides / Q000378:metabolism; D014527:Uric Acid / Q000378:metabolism
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D014527:Uric Acid; D003404:Creatinine