Area under the curve for estradiol levels do not consistently reflect estradiol levels on the day of hCG administration in patients undergoing controlled ovarian hyperstimulation for IVF-ET.
OBJECTIVE
Most studies reported estradiol (E2) levels attained on day of hCG administration when investigating effect of E2 on IVF outcome. We studied whether a relationship exists between the area under the curve for E2 levels (AUC-E2) and E2 levels on hCG day during IVF-ET.


METHODS
Retrospectively, we analyzed data for 313 patients who completed one IVF-ET cycle each. Patients were sorted according to AUC-E2 levels. Then we compared between each patient's own AUC-E2 and the corresponding E2 level on hCG day for the same patient.


RESULTS
Although overall AUC-E2 correlated positively with E2 levels on hCG day, there was no consistent correlation between individual patients.


CONCLUSIONS
AUC-E2 reflects more accurately the amount of E2 produced by the follicles during controlled ovarian hyperstimulation. The absence of a uniform correlation between AUC-E2 and E2 on hCG day may result in different conclusions when studying outcomes of IVF treatment.
Mitwally
Mohamed F M
MF
Department of Gynecology and Obstetrics, School of Medicine and Health Sciences, University at Buffalo, State University of New York (SUNY), 219 Bryant Street, Buffalo, New York 14222, USA.
Bhakoo
Hemlata S
HS
Crickard
Kent
K
Sullivan
Michael W
MW
Batt
Ronald E
RE
Yehl
John
J
D019540:Area Under Curve; D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000627:therapeutic use; D004624:Embryo Transfer; D004958:Estradiol / Q000097:blood* / Q000493:pharmacokinetics*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D006080:Ovarian Follicle / Q000187:drug effects / Q000502:physiology; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013997:Time Factors
D006063:Chorionic Gonadotropin; D004958:Estradiol