title: A polymorphism in the matrix metalloproteinase-1 gene promoter is associated with the presence of polycystic ovary syndrome in Caucasian women.
abstract: A common -1607 GG/G polymorphism of the matrix metalloproteinase-1 (MMP1) gene promoter was investigated in a series of Caucasian women with polycystic ovary syndrome (PCOS) and controls, by direct sequencing. In this prospective case-control study, the odds for women with at least one mutant GG allele of the MMP1 promoter to be diagnosed with PCOS was 2.7.
authors.affiliation: Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, Austria. katharina.walch@meduniwien.ac.at
authors.forename: Katharina
authors.initials: K
authors.lastname: Walch
authors.forename: Friedrich
authors.initials: F
authors.lastname: Nagele
authors.forename: Robert
authors.initials: R
authors.lastname: Zeillinger
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Vytiska-Binstorfer
authors.forename: Johannes C
authors.initials: JC
authors.lastname: Huber
authors.forename: Lukas A
authors.initials: LA
authors.lastname: Hefler
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000235:genetics*; D016017:Odds Ratio; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011446:Prospective Studies; D044465:White People / Q000235:genetics*
chemical_list: D020781:Matrix Metalloproteinase 1