title: [Clinical-epidemiological study of toxocariasis in a pediatric population].
abstract: OBJECTIVE
  The variety of toxocariasis clinic manifestations and its relationship with asthma motivated this study. The aim was to study T.canis seropositivity at a public pediatric service and its association with laboratory, epidemiological and clinical factors.
  
  
  METHODS
  This study was cross-sectional and controlled. Two hundred and eight children, from 1 to 14 years old and treated at the University of Santo Amaro Pediatric Department s Immunology and Pneumology clinic between January 2000 and January 2001, underwent serology testing. Antibodies were detected by ELISA testing for the larval excretory-secretory antigen of T. canis. We used the chi-square test for T.canis seropositivity (titers > or = 1:320) associations with: puppies at home, contact with soil, geophagia, onicophagia, mother's educational level, asthma, chronic cough, repetitive pneumonia, skin manifestations, rhinitis, hepatomegaly, splenomegaly, abdominal pain, anemia, eosinophilia, immunoglobulins, parasitosis and stunted growth. The Kruskal-Wallis variance analysis method was used for mean comparisons between seropositive and seronegative groups. Significance was set at p < or = 0.05.
  
  
  RESULTS
  Seroprevalence was 54.8%, with a mean age of 6.5 years while for seronegative children the mean age was 5.8 years, showing no significant difference. There was also no difference between sexes. Seropositivity was significantly associated with puppies at home, contact with soil, hepatomegaly, asthma, eosinophilia, increased serum immunoglobulin (Ig) E levels and stunted growth.
  
  
  CONCLUSIONS
  Seroprevalence was elevated in this study . T.canis infection must be considered in at-risk children, such as those with puppies at home, who have had contact with soil, who have hepatomegaly and/or asthma with eosinophilia and increased serum IgE.
authors.affiliation: Universidade de Santo Amaro (UNISA), São Paulo, SP. kwcm@ig.com.br
authors.forename: Silvana D P
authors.initials: SD
authors.lastname: Figueiredo
authors.forename: José A A C
authors.initials: JA
authors.lastname: Taddei
authors.forename: Joaquim J C
authors.initials: JJ
authors.lastname: Menezes
authors.forename: Neil F
authors.initials: NF
authors.lastname: Novo
authors.forename: Elizabete O M
authors.initials: EO
authors.lastname: Silva
authors.forename: Helena L G
authors.initials: HL
authors.lastname: Cristóvão
authors.forename: Maria C F S
authors.initials: MC
authors.lastname: Cury
mesh_terms: D000293:Adolescent; D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood / Q000302:isolation & purification*; D001249:Asthma / Q000469:parasitology; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D017166:Toxocara canis / Q000276:immunology* / Q000302:isolation & purification; D014120:Toxocariasis / Q000097:blood / Q000150:complications / Q000453:epidemiology*
chemical_list: D000909:Antibodies, Helminth