Synthesis and properties of different metal complexes of the siderophore desferriferricrocin.
Desferriferricrocin is a cyclic hexa-peptide siderophore with three hydroxamates as primary coordination groups. It forms metal complexes with Fe(III), Cr(III), Al(III), Ga(III), Cu(II), and Zn(II). These complexes were prepared and characterized using UV-vis, circular dichroism spectroscopy (CD), nuclear magnetic resonance spectroscopy (NMR), and electrospray ionization mass spectroscopy (ESI-MS). The mononuclear trivalent metal complexes of desferriferricrocin were stable in aqueous solutions, and their coordination centers primarily adopted the lambda configuration. The formation of multinuclear complexes of desferriferricrocin was determined by ESI-MS. Desferriferricrocin was able to bind up to three Cu(II) and two Zn(II) respectively. Heteronuclear complexes containing one trivalent and one divalent were also determined. In these complexes, amide nitrogens were utilized as alternative binding groups of desferriferricrocin in addition to the primary binding groups, the hydroxamates.
Zou
Guozhang
G
Department of Chemistry, State University of New York, College of Environmental Science and Forestry, Syracuse, New York 13210, USA.
Boyer
Gregory L
GL
D023181:Antimicrobial Cationic Peptides; D002851:Chromatography, High Pressure Liquid; D002942:Circular Dichroism; D003300:Copper / Q000737:chemistry; D005291:Ferrichrome / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D006877:Hydroxamic Acids / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008670:Metals / Q000737:chemistry; D008956:Models, Chemical; D011485:Protein Binding; D017262:Siderophores / Q000138:chemical synthesis* / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D014466:Ultraviolet Rays; D014867:Water / Q000737:chemistry; D015032:Zinc / Q000737:chemistry
D023181:Antimicrobial Cationic Peptides; D006877:Hydroxamic Acids; D008670:Metals; D017262:Siderophores; D014867:Water; D005291:Ferrichrome; C048996:N-desferriferrichrome; C015790:desferri-ferricrocin; D003300:Copper; D015032:Zinc