title: Development and applications of a software for Functional Image Registration (FIRE).
abstract: Image registration with anatomical modalities, such as CT and MRI, facilitates the anatomical identification and localization in the interpretation of nuclear medicine images that lack anatomical information. The implementation of Functional Image Registration (FIRE), an operating system (OS) and platform independent multimodal image registration software is reported. In order to register the images without an operator's interaction, several automatic algorithms were implemented. These include principal axes matching and maximization of the mutual information methods. The user interface was designed to support the manual registration of the images. Fused images were composed by overlaying one image with the other one transparently, in which the opacity of the overlaid image was interactively controlled. FIRE was successfully applied to many clinical cases for which automatic and/or manual registration was required. An OS and platform independent program for image registration developed in this study will be useful for the clinical application of image registration techniques.
authors.affiliation: Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Jae Sung
authors.initials: JS
authors.lastname: Lee
authors.forename: Kwang Suk
authors.initials: KS
authors.lastname: Park
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Lee
authors.forename: Choong Woong
authors.initials: CW
authors.lastname: Lee
authors.forename: June-Key
authors.initials: JK
authors.lastname: Chung
authors.forename: Myung Chul
authors.initials: MC
authors.lastname: Lee
mesh_terms: D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D006801:Humans; D007089:Image Enhancement; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D009683:Nuclear Medicine; D012984:Software; D014057:Tomography, X-Ray Computed; D014584:User-Computer Interface