Serum lipids concentration in women with benign and malignant ovarian tumours.
Early diagnosis can improve clinical effects of ovarian carcinoma treatment. Until now, a satisfying screening method has not been found. Serum lipid and lipoprotein association with neoplasm is already established. In our study, we have examined concentration of total cholesterol, free cholesterol, HDL cholesterol, HDL3 and HDL free cholesterol fraction, triglycerides, and apolipoproteins: AI, AII and B and aimed to prepare the most likely model of lipid profile in women suffering from ovarian neoplasm. The serum lipid parameters were analysed in 91 operated patients: 64 with ovarian malignant tumour, 27 with benign ovarian cysts and 44 apparently healthy age-matching pair women as a control group.


RESULTS
concentration of two parameters: apolipoprotein AI and free cholesterol allows for excluding ovarian neoplasm in 95.5%; examination of six parameters: apolipoprotein AI, free cholesterol, HDL-free cholesterol, HDL total cholesterol, apolipoprotein B and HDL3 fraction allows for diagnosing ovarian malignancy with 97% probability. This probability does not depend on staging of cancer, patient's age, nor BMI. No statistically significant difference between malignant and benign ovarian tumour has been confirmed.
Gadomska
Halina
H
Department of Gynaecology and Obstetrics, University College of Medicine, PI. Starynkiewicza 1/3, 02-015 Warsaw, Poland. j.gadomski1@chello.pl
Grzechocińska
Barbara
B
Janecki
Jerzy
J
Nowicka
Grazyna
G
Powolny
Michał
M
Marianowski
Longin
L
D000328:Adult; D000368:Aged; D016632:Apolipoprotein A-I / Q000097:blood; D016633:Apolipoprotein A-II / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D053440:Lipoproteins, HDL3; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood*; D014280:Triglycerides / Q000097:blood
D016632:Apolipoprotein A-I; D016633:Apolipoprotein A-II; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008055:Lipids; D008075:Lipoproteins, HDL; D053440:Lipoproteins, HDL3; D014280:Triglycerides; D002784:Cholesterol