title: Factors associated with the presence of nonalcoholic steatohepatitis in patients with chronic hepatitis C.
abstract: OBJECTIVE
  The aim of this study was to identify factors associated with the presence of nonalcoholic steatohepatitis (NASH) in patients with chronic hepatitis C (CHC).
  
  
  METHODS
  We studied 98 patients with CHC [47 with NASH (group HCV/NASH), 51 without NASH (group HCV)] and 85 with NASH not infected with hepatitis C virus (HCV) (group NASH). We determined factors associated with the presence of NASH in patients with hepatitis C.
  
  
  RESULTS
  Group HCV/NASH patients resembled those with NASH. Body mass index (BMI) was higher in group HCV/NASH than in group HCV, but was similar to group NASH. Most HCV/NASH patients had risk factors for NASH. In patients infected with HCV, NASH and NASH-related lesions were independently associated with BMI, while steatosis score was associated with HCV genotype 3 and BMI. Fibrosis stage was independently associated with steatosis, necroinflammatory activity index, and NASH lesions.
  
  
  CONCLUSIONS
  While HCV genotype 3 infection and BMI are associated with the presence of steatosis in CHC, BMI is the only factor independently associated with the presence of NASH in these patients. We suggest that overweight-related factors might induce NASH in CHC patients.
authors.affiliation: Departments of Gastroenterology and Pathology, Hospital Universitario Doce de Octubre, Madrid, Spain.
authors.forename: José A
authors.initials: JA
authors.lastname: Solis-Herruzo
authors.forename: Mercedes
authors.initials: M
authors.lastname: Pérez-Carreras
authors.forename: Eloy
authors.initials: E
authors.lastname: Rivas
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Fernández-Vázquez
authors.forename: Cristina
authors.initials: C
authors.lastname: Garfia
authors.forename: Esther
authors.initials: E
authors.lastname: Bernardos
authors.forename: Gregorio
authors.initials: G
authors.lastname: Castellano
authors.forename: Francisco
authors.initials: F
authors.lastname: Colina
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001706:Biopsy; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D005234:Fatty Liver / Q000097:blood / Q000150:complications* / Q000473:pathology; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000145:classification / Q000235:genetics; D006505:Hepatitis / Q000097:blood / Q000150:complications* / Q000473:pathology; D019698:Hepatitis C, Chronic / Q000097:blood / Q000150:complications* / Q000473:pathology / Q000821:virology; D022781:Hepatocytes / Q000473:pathology; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D011446:Prospective Studies; D012307:Risk Factors; D014168:Transferrin / Q000032:analysis; D014280:Triglycerides / Q000097:blood
chemical_list: D014168:Transferrin; D014280:Triglycerides; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase