Neuropathy resembling CIDP in patients receiving tumor necrosis factor-alpha blockers.
Tumor necrosis factor-alpha (TauNuFalpha) blockers are effective in the treatment of inflammatory arthritis but can induce autoimmune disorders including multiple sclerosis. Described are two patients who developed chronic inflammatory demyelinating polyneuropathy after initiation of anti-TNFalpha treatment.
Richez
C
C
Service de Rhumatologie, Groupe Hospitalier Pellegrin, CHU de Bordeaux, Bordeaux, France. christophe.richez@club-internet.fr
Blanco
P
P
Lagueny
A
A
Schaeverbeke
T
T
Dehais
J
J
D000368:Aged; D000911:Antibodies, Monoclonal / Q000009:adverse effects; D018501:Antirheumatic Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001323:Autoantibodies / Q000187:drug effects / Q000276:immunology; D000068800:Etanercept; D005260:Female; D005677:G(M1) Ganglioside / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000009:adverse effects; D000069285:Infliximab; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000139:chemically induced / Q000276:immunology / Q000503:physiopathology; D009431:Neural Conduction / Q000187:drug effects / Q000276:immunology; D010525:Peripheral Nerves / Q000187:drug effects* / Q000276:immunology / Q000503:physiopathology; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000139:chemically induced* / Q000276:immunology / Q000503:physiopathology; D018124:Receptors, Tumor Necrosis Factor; D020127:Recovery of Function / Q000276:immunology; D012678:Sensation Disorders / Q000139:chemically induced / Q000276:immunology / Q000503:physiopathology; D013167:Spondylitis, Ankylosing / Q000188:drug therapy; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
D000911:Antibodies, Monoclonal; D018501:Antirheumatic Agents; D001323:Autoantibodies; D007074:Immunoglobulin G; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D005677:G(M1) Ganglioside; D000069285:Infliximab; D000068800:Etanercept