title: Weight gain after living-related renal transplantation affects long-term graft function.
abstract: Weight gain is a common problem in renal transplant recipients. This study investigated whether weight gain after living-related renal transplantation affects long-term graft function. The cohort included 93 patients (28 females, 65 males of mean age, 33.78 +/- 9.78 years who were recipients of kidneys from living-related donors. The data set related risk factors to occurrence of chronic allograft nephropathy (CAN): namely, number of HLA mismatches, PRA levels, delayed graft function, acute rejection, suboptimal immunosuppression, hypertension, hyperlipidemia, and size mismatch. Patients with a 10% increase in body mass index sustained throughout at least 2 years posttransplantation were categorized as group 1 (abnormal weight gain; n = 65) and the others were categorized as group 2 (no or normal weight gain; n = 28). Chronic allograft nephropathy was more frequent among group 1 (P < .03). The mean times to CAN diagnosis in groups 1 and 2 were 1053.41 +/- 461.86 days and 1128.57 +/- 416.09 days, respectively (P > .05). Of all the risk factors for CAN, occurrence of acute rejection was the most important (OR = 5.39, 95% CI: 2.07 to 14.03, P < .001). When this factor was excluded, weight gain emerged as the most important risk factor (OR = 3.04, 95% CI: 1.01 to 9.69, P < .04). There were no significant differences between the groups with respect to the frequencies of immunologic and nonimmunologic risk factors (P > .05 for all). The results suggest that excessive weight gain after living-related renal transplantation may be an additional risk factor for development of CAN. Patients should pay attention to diet and control weight gain after transplantation.
authors.affiliation: Department of Nephrology, Baskent University Hospital of Adana, Adana, Turkey. hasanmicoz@hotmail.com
authors.forename: H
authors.initials: H
authors.lastname: Micozkadioglu
authors.forename: F N
authors.initials: FN
authors.lastname: Ozdemir
authors.forename: S
authors.initials: S
authors.lastname: Sezer
authors.forename: Z
authors.initials: Z
authors.lastname: Arat
authors.forename: M
authors.initials: M
authors.lastname: Haberal
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006650:Histocompatibility Testing; D006801:Humans; D007518:Isoantibodies / Q000097:blood; D016030:Kidney Transplantation / Q000473:pathology / Q000502:physiology*; D008055:Lipids / Q000097:blood; D019520:Living Donors; D008297:Male; D008499:Medical Records; D012189:Retrospective Studies; D015430:Weight Gain / Q000502:physiology*
chemical_list: D007518:Isoantibodies; D008055:Lipids