title: Reduced sustained brain activity during processing of positive emotional stimuli in major depression.
abstract: BACKGROUND
  This study examines the directionality and temporal specificity of brain activity during sustained processing of emotional stimuli in individuals with current major depressive disorder (MDD) and nondepressed control participants.
  
  
  METHODS
  Slow wave (SW) components of the event-related brain potential (ERP) were recorded from 16 control participants and 15 participants with MDD during a working memory task. During the task, individuals were shown a positive, neutral, or negative word and were asked to maintain it in memory for 5 sec. Participants then saw a letter and had to decide whether it was a part of the previously presented word. The ERP components were measured from nine scalp sites (F3, Fz, F4, C3, Cz, C4, P3, Pz, P4) during the encoding of emotional words.
  
  
  RESULTS
  Compared with control individuals, MDD participants exhibited decreased brain responses to positive relative to negative or neutral stimuli. This decrease in brain activity during processing of positive information was evident across all sites and SW components.
  
  
  CONCLUSIONS
  Our findings suggest that cognitive deficits in MDD may stem from diminished brain responses during processing of positive information and may not be associated with an augmented response to negative stimuli.
authors.affiliation: Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA. shestyuk@wjh.harvard.edu
authors.forename: Avgusta Y
authors.initials: AY
authors.lastname: Shestyuk
authors.forename: Patricia J
authors.initials: PJ
authors.lastname: Deldin
authors.forename: Jordan E
authors.initials: JE
authors.lastname: Brand
authors.forename: Christen M
authors.initials: CM
authors.lastname: Deveney
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001143:Arousal / Q000502:physiology; D001921:Brain / Q000503:physiopathology*; D003071:Cognition / Q000502:physiology; D003865:Major Depressive Disorder / Q000503:physiopathology*; D004569:Electroencephalography; D004585:Electrooculography; D004644:Emotions / Q000502:physiology*; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time / Q000502:physiology