[Application of positron emission tomography in diagnosis and staging for lung cancer].
OBJECTIVE
To determine the usefulness of positron emission tomography with fluoro-2-deoxyglucose (FDG-PET) in lung cancer.


METHODS
From September 1999 to April 2003, patients with lung cancer or indeterminate lung lesions on chest CT scan were enrolled, and underwent FDG-PET scanning.


RESULTS
Of 104 patients, 64 (60%) had malignancy and 40 (40%) had a benign process. The standard uptake ratio (SUV) in patients with lung cancer was significantly higher than that in patients with benign disease, 4.5 (1.2 - 11.7) and 1.0 (0 - 7.7) respectively. The SUV was not related with histologic type, differentiation, staging and the size of lesion. The diagnostic sensitivity, specificity and accuracy of PET imaging for lung cancer were 88%, 85% and 87% respectively, and the diagnostic specificity and accuracy for lung cancer with PET were significant higher than those with CT scan. The specificity and accuracy of lung lesions with a diameter >or= 1.5 cm with SUV method was better than that of lesions with a diameter < 1.5 cm. In 6 false positive patients, 4 were tuberculosis, 1 fungal infection and 1 organic pneumonia. Both PET and CT scan were poorly sensitive and specific for detecting local lymph node metastasis.


CONCLUSIONS
PET had advantages in evaluation of lung lesions, and integrated PET and CT were recommended for detecting local lymph node metastasis.
Wang
Meng-zhao
MZ
Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Li
Long-yun
LY
Zhu
Zhao-hui
ZH
Song
Zhi-feng
ZF
D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography / Q000379:methods*; D012680:Sensitivity and Specificity
D019788:Fluorodeoxyglucose F18