title: [Optic neuritis associated with infliximab].
abstract: Infliximab is a chimeric human-murine monoclonal antibody of the IgG1 type with a high affinity and specificity for tumor necrosis factor alpha (TNFalpha). Infliximab was used in Crohn disease, rheumatoid arthritis, spondyloarthropathy, juvenile idiopathic arthritis, Behcet's disease, Wegener's granulomatosis, HLA-B27-associated uveitis and chronic severe refractory uveitis. Reported adverse effects of this treatment were infections, development of antinuclear antibodies and anti double-stranded DNA, lymphomas, and exacerbation of demyelinating disease. We report a case of infliximab-associated optic neuritis with favorable outcome after systemic steroid treatment.
authors.affiliation: Service d'Ophtalmologie, 75013 Paris, France.
authors.forename: T H C
authors.initials: TH
authors.lastname: Tran
authors.forename: D
authors.initials: D
authors.lastname: Milea
authors.forename: N
authors.initials: N
authors.lastname: Cassoux
authors.forename: B
authors.initials: B
authors.lastname: Bodaghi
authors.forename: P
authors.initials: P
authors.lastname: Bourgeois
authors.forename: P
authors.initials: P
authors.lastname: LeHoang
mesh_terms: D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D018501:Antirheumatic Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D000069285:Infliximab; D008875:Middle Aged; D009902:Optic Neuritis / Q000139:chemically induced*
chemical_list: D000911:Antibodies, Monoclonal; D018501:Antirheumatic Agents; D000069285:Infliximab