title: Leptolide, a new furanocembranolide diterpene from Leptogorgia alba.
abstract: Six furanocembranolides (1-6) and one pseudopterolide (7) have been isolated from the octocorals Leptogorgia alba and Leptogorgia rigida, collected on the Pacific coast of Panama. Compound 1, named leptolide, has a new structure closely related to the neurotoxin lophotoxin (3). The X-ray structures of 1-3 were determined, and the absolute configurations of 2-7 are discussed. Compounds 1-7 were evaluated in vitro against drug-resistant Plasmodium falciparum.
authors.affiliation: Departamento de Química Orgánica, Instituto de Acuicultura y Unidad de RMN de Biomoléculas Asociada al CSIC, Universidad de Santiago de Compostela, E-15782 Santiago de Compostela, Spain.
authors.forename: Marcelino
authors.initials: M
authors.lastname: Gutiérrez
authors.forename: Todd L
authors.initials: TL
authors.lastname: Capson
authors.forename: Héctor M
authors.initials: HM
authors.lastname: Guzmán
authors.forename: José
authors.initials: J
authors.lastname: González
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ortega-Barría
authors.forename: Emilio
authors.initials: E
authors.lastname: Quiñoá
authors.forename: Ricardo
authors.initials: R
authors.lastname: Riguera
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D001952:Bridged-Ring Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004351:Drug Resistance; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D010140:Pacific Ocean; D010176:Panama; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D001952:Bridged-Ring Compounds; D004224:Diterpenes; D005663:Furans; D007783:Lactones; C447624:furanocembranolide; C501150:leptolide; C074182:pseudopterolide