title: Acute fatty liver of pregnancy -- an underlying condition for herpes simplex type 2 fulminant hepatitis necessitating liver transplantation.
abstract: The infrequent occurrence of herpes simplex virus (HSV) hepatitis in healthy women in comparison with the high prevalence of HSV infections suggests that, in addition to deranged immunity, an underlying condition in the liver might be necessary to develop HSV hepatitis. We report the case of a 28-year-old pregnant woman in the 28 (th) week of gestation. Following HSV type 2 infection of the uterine cervix, acute liver failure developed, necessitating urgent liver transplantation. In addition to fulminant HSV type 2 hepatitis, the explanted liver also showed the histological features of acute fatty liver of pregnancy. The presented case suggests a possible pathogenetic role of acute fatty liver of pregnancy in the development of fulminant HSV hepatitis following recurrent infection with HSV in healthy pregnant women. We believe that early histopathological diagnosis, followed by specific antiviral treatment and liver transplantation in selected patients may improve the clinical outcome of otherwise almost uniformly fatal HSV hepatitis.
authors.affiliation: Institute of Pathology, Medical Faculty, Ljubljana, Slovenia. bostjan.luzar@mf.uni-lj.si
authors.forename: B
authors.initials: B
authors.lastname: Luzar
authors.forename: V
authors.initials: V
authors.lastname: Ferlan-Marolt
authors.forename: M
authors.initials: M
authors.lastname: Poljak
authors.forename: V
authors.initials: V
authors.lastname: Sojar
authors.forename: D
authors.initials: D
authors.lastname: Stanisavljević
authors.forename: T
authors.initials: T
authors.lastname: Bukovac
authors.forename: S
authors.initials: S
authors.lastname: Markovic
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D001706:Biopsy; D002584:Cervix Uteri / Q000473:pathology; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005234:Fatty Liver / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology / Q000601:surgery*; D005260:Female; D006506:Hepatitis A / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology / Q000601:surgery*; D022781:Hepatocytes / Q000473:pathology; D006558:Herpes Genitalis / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology / Q000601:surgery*; D018258:Herpesvirus 2, Human / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D008099:Liver / Q000473:pathology; D017114:Liver Failure, Acute / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology / Q000601:surgery*; D016031:Liver Transplantation; D009894:Opportunistic Infections / Q000175:diagnosis* / Q000276:immunology / Q000601:surgery*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology / Q000601:surgery*; D011262:Pregnancy Trimester, Second; D011379:Prognosis; D012307:Risk Factors; D002575:Uterine Cervicitis / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology / Q000601:surgery*
chemical_list: D000998:Antiviral Agents