title: Relationship between objective measures of peripheral arterial disease severity to self-reported quality of life in older adults with intermittent claudication.
abstract: OBJECTIVE
  The aim of this study was to determine the relation between functional measures of peripheral arterial disease (PAD) severity with both disease-specific and generic self-reported health-related quality-of-life (HR-QOL) measures, as well as the relation between the two types of HR-QOL measures.
  
  
  METHODS
  This was a cross-sectional observation of participants from the community and primary care or vascular surgery clinics in an academic Veterans Administration medical center. Eighty patients with symptomatic Fontaine stage II PAD provided physiologic measures and self-response questionnaires. Objective measures included the ankle-brachial index (ABI), time to maximum claudication pain on a graded exercise test, and a 6-minute floor-walking distance. Self-reports included the Walking Impairment Questionnaire (WIQ), a disease-specific HR-QOL measure and the Medical Outcomes Study (MOS) Short-Form 36 (SF-36), a generic HR-QOL measure.
  
  
  RESULTS
  Patients (mean age 70 +/- 8 [+/- SD] and 85% men) exhibited moderate-to-severe PAD by objective measures of ABI (0.65 +/- 0.19) and time in minutes to maximal claudication on a graded exercise test (7:54 +/- 4:58). Significant correlations were found between these measures and the WIQ distance, MOS-Physical Function, and MOS-Role Limitations due to physical dysfunction. The SF-36 and the WIQ subscales were significantly correlated.
  
  
  CONCLUSIONS
  In older PAD patients with intermittent claudication, objective measures of disease severity are correlated with a self-reported, disease-specific and generic HR-QOL.
authors.affiliation: Department of Medicine, Franklin Square Hospital Center, Baltimore, MD, USA.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Izquierdo-Porrera
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Gardner
authors.forename: Douglas D
authors.initials: DD
authors.lastname: Bradham
authors.forename: Polly S
authors.initials: PS
authors.lastname: Montgomery
authors.forename: John D
authors.initials: JD
authors.lastname: Sorkin
authors.forename: Claudia C
authors.initials: CC
authors.lastname: Powell
authors.forename: Leslie I
authors.initials: LI
authors.lastname: Katzel
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D003430:Cross-Sectional Studies; D005080:Exercise Test; D005260:Female; D006304:Health Status; D006801:Humans; D007383:Intermittent Claudication / Q000503:physiopathology* / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012720:Severity of Illness Index; D016138:Walking / Q000502:physiology