Synthesis and optical resolution of 2-aryl-2-fluoropropionic acids, fluorinated analogues of non-steroidal anti-inflammatory drugs (NSAIDs).
We report the synthesis of optically active 2-aryl-2-fluoropropionic acids 2 as non-epimerizable mimics of 2-arylpropionic acids 1, a class of compounds which have been widely used as non-steroidal anti-inflammatory drugs (NSAIDs). This is a continuation of our research involving the design, synthesis, and evaluation of chiral fluorine-containing organic molecules as effective analogues of pharmacologically important compounds.
Fujisawa
Hidehito
H
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugatani 2630, Toyama 930-194, Japan.
Fujiwara
Tomoya
T
Takeuchi
Yoshio
Y
Omata
Kenji
K
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D008968:Molecular Conformation; D009904:Optical Rotation; D011422:Propionates / Q000138:chemical synthesis*; D011433:Propranolol / Q000031:analogs & derivatives* / Q000138:chemical synthesis
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; C406244:fluoropropranolol; D011433:Propranolol