title: Risk-adapted multimodal laboratory cervical screening -- application of new technologies to cervical cancer prevention.
abstract: The objective of screening for cervical cancer is to reduce the mortality and incidence of the disease. To date, there is extensive and strong evidence that this can be achieved by cytology-based screening programs, which continue to be the mainstay of cervical prevention worldwide despite their inherent methodological limitations. This article presents a review on the utility of conventional, ancillary, and experimental methods for cervical screening both as single tests and test-combinations, and describes possible future directions for enhanced screening accuracy using risk-adapted protocols.
authors.affiliation: Institute of Pathology, Bonn-Duisdorf, Germany.
authors.forename: Reinhard
authors.initials: R
authors.lastname: Bollmann
authors.forename: Agnes
authors.initials: A
authors.lastname: Bankfalvi
authors.forename: Magdolna
authors.initials: M
authors.lastname: Bollmann
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D002471:Cell Transformation, Neoplastic; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D027383:Papillomaviridae; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000517:prevention & control*
chemical_list: D014408:Biomarkers, Tumor; D004279:DNA, Viral