title: Use of surodex in phacotrabeculectomy surgery.
abstract: OBJECTIVE
  To evaluate the use of Surodex (Oculex Pharmaceuticals, Sunnyvale, California) a drug delivery system incorporating 60 micrograms of dexamethasone in a pellet, in phacotrabeculectomy surgery.
  
  
  METHODS
  Nonrandomized, prospective, interventional case series.
  
  
  METHODS
  Phacotrabeculectomy was performed on 37 Asian subjects with primary open-angle glaucoma (POAG) using a standardized technique. All subjects received a Surodex pellet underneath the scleral flap. Results were compared with those of 31 POAG subjects who had undergone phacotrabeculectomy augmented with 50 mg/ml of intraoperative 5-fluorouracil (5-FU) during the same period.
  
  
  RESULTS
  Mean follow-up in months was 19.7 +/- 7.9 and 22.1 +/- 6.2 for the Surodex and 5-FU groups, respectively (P = .29). There was a 20.1% decrease in intraocular pressure in the Surodex group compared with 28.5% decrease in the 5-FU group (P = .6). Postoperative complications occurred in three cases (8.1%) and six cases (19.3%), respectively (P = .04).
  
  
  CONCLUSIONS
  Combined phacotrabeculectomy surgery augmented by intra-scleral placement of Surodex results in good control of IOP and a low incidence of complications.
authors.affiliation: Singapore National Eye Center, 11 Third Hospital Avenue, Singapore 168751.
authors.forename: Steve K L
authors.initials: SK
authors.lastname: Seah
authors.forename: Rahat
authors.initials: R
authors.lastname: Husain
authors.forename: Gus
authors.initials: G
authors.lastname: Gazzard
authors.forename: Marcus C C
authors.initials: MC
authors.lastname: Lim
authors.forename: Sek-Tien
authors.initials: ST
authors.lastname: Hoh
authors.forename: Francis T S
authors.initials: FT
authors.lastname: Oen
authors.forename: Tin
authors.initials: T
authors.lastname: Aung
mesh_terms: D000869:Anterior Eye Segment / Q000187:drug effects; D003907:Dexamethasone / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D005472:Fluorouracil / Q000008:administration & dosage; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000601:surgery*; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007429:Intraocular Pressure; D018918:Phacoemulsification / Q000379:methods*; D011183:Postoperative Complications; D011446:Prospective Studies; D013524:Surgical Flaps; D014130:Trabeculectomy / Q000379:methods*
chemical_list: D005938:Glucocorticoids; D003907:Dexamethasone; D005472:Fluorouracil