Nutritional programming of adult disease.
Intrauterine and early neonatal life is a period of physiological plasticity, during which environmental influences may produce long-term effects. Both undernutrition and overnutrition during this period have been shown to change disease risk in adulthood. These effects are influenced by the type, timing and duration of inappropriate nutrition and by the previous nutritional environment and may not be reflected in changes in body size. An understanding of the interaction between nutrient imbalance and alteration of gene expression is likely to be the key to optimising future health outcomes.
Buckley
Alex J
AJ
Liggins Institute, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand.
Jaquiery
Anne L
AL
Harding
Jane E
JE
D000818:Animals; D001835:Body Weight; D004032:Diet; D004194:Disease / Q000209:etiology*; D005260:Female; D005333:Fetus / Q000502:physiology; D005786:Gene Expression Regulation; D006801:Humans; D039382:Maternal Nutritional Physiological Phenomena; D018977:Micronutrients / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D039401:Prenatal Nutritional Physiological Phenomena
D018977:Micronutrients