The social life of ribosomal proteins.
Ribosomal proteins hold a unique position in biology because their function is so closely tied to the large rRNAs of the ribosomes in all kingdoms of life. Following the determination of the complete crystal structures of both the large and small ribosomal subunits from bacteria, the functional role of the proteins has often been overlooked when focusing on rRNAs as the catalysts of translation. In this review we highlight some of the many known and important functions of ribosomal proteins, both during translation on the ribosome and in a wider context.
Brodersen
Ditlev E
DE
Centre for Structural Biology, Department of Molecular Biology, University of Aarhus, Denmark. deb@mb.au.dk
Nissen
Poul
P
D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D001665:Binding Sites; D006801:Humans; D008958:Models, Molecular; D010458:Peptidyl Transferases / Q000737:chemistry / Q000378:metabolism; D014176:Protein Biosynthesis; D011487:Protein Conformation; D012333:RNA, Messenger / Q000378:metabolism; D012343:RNA, Transfer / Q000378:metabolism; D012269:Ribosomal Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D012270:Ribosomes / Q000737:chemistry / Q000378:metabolism
D001426:Bacterial Proteins; D012333:RNA, Messenger; D012269:Ribosomal Proteins; D012343:RNA, Transfer; D010458:Peptidyl Transferases