Death squads enlisted by the tumour suppressor p53.
p53 is a tumour suppressor that is found mutated or functionally inactivated in more than half of all human cancers. p53 function is activated by DNA damage, hypoxia, expression of certain oncogenes, and many cytotoxic stimuli. p53 is a transcription factor that regulates expression of target genes which promote apoptotic cell death, cell cycle arrest, cellular senescence, and some other processes. In this review we summarise current knowledge of p53 target genes implicated in apoptosis signalling.
Michalak
Ewa
E
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.
Villunger
Andreas
A
Erlacher
Miriam
M
Strasser
Andreas
A
D000818:Animals; D017209:Apoptosis; D020169:Caspases / Q000502:physiology; D015687:Cell Hypoxia / Q000502:physiology; D002460:Cell Line; D004249:DNA Damage; D004721:Endoplasmic Reticulum / Q000502:physiology; D016158:Genes, p53; D006801:Humans; D018384:Oxidative Stress; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*
D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53; D020169:Caspases