Effect of compression on interaction between 1,4-dihydropyridine compounds and lactose monohydrate.
Manidipine dihydrochloride or benidipine hydrochloride will change to hydrate form in part, when differential scanning calorimetric (DSC) measurement is carried out together with lactose monohydrate. This interaction was accelerated by compressing their mixture. It can be suggested that the interaction may cause by the disruption of crystal structure of lactose monohydrate due to compression to set free of water molecules. A new DSC peak at 170 degrees C, which was not observed in each component, appeared in DSC measurement of a mixture. This will be based on hydrate formed by the interaction, i.e., movement of water molecules. The profile of the plotting of the DSC peak area ratio before and after compression against the compression force changed by the molar ratio of lactose monohydrate in a mixture. In the case of low molar ratio of lactose monohydrate, profiles for manidipine dihydrochloride and benidipine hydrochloride differed from each other. This will be because manidipine dihydrochloride is stickier than benidipine hydrochloride. The profile for manidipine dihydrochloride became more gradual and showed lag compression force region when the amount of addition of the lubricant, magnesium stearate in a mixture increased. The endothermic peak area at 170 degrees C for manidipine dihydrochloride was larger than that for benidipine hydrochloride. It should be suggested that benidipine hydrochloride is easier to be transformed to its hydrate than manidipine dihydrochloride.
Hosaka
Shouichi
S
Research and Development Division, Sawai Pharmaceutical Co., Ltd., 1-3-8 Akagawa, Osaka 535-0005, Japan. s.hosaka@sawai.co.jp
Sato
Mika
M
Ozawa
Yoshiki
Y
Hamada
Chikayuki
C
Takahashi
Yoshiteru
Y
Kitamori
Nobuyuki
N
D019245:Compressive Strength; D004095:Dihydropyridines / Q000032:analysis* / Q000737:chemistry*; D004347:Drug Interactions; D007785:Lactose / Q000032:analysis* / Q000737:chemistry*; D013696:Temperature
D004095:Dihydropyridines; C038806:1,4-dihydropyridine; D007785:Lactose