"Sweet talk": closing in on C type lectin signaling.
C type lectins recognize pathogens by binding to pathogen-specific carbohydrate residues. The finding reported by Rogers et al. (2005) in this issue of Immunity, that ligand binding by the C type lectin Dectin-1 leads to recruitment of the tyrosine kinase Syk and is critical to subsequent cytokine production by the cell, will surely inspire further research on the mechanisms of carbohydrate receptor signaling.
Meyer-Wentrup
Friederike
F
Department of Tumor Immunology, Nijmegen Centre of Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Cambi
Alessandra
A
Adema
Gosse J
GJ
Figdor
Carl G
CG
D000818:Animals; D016207:Cytokines / Q000096:biosynthesis; D004792:Enzyme Precursors / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins; D037181:Lectins, C-Type / Q000276:immunology / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction; D000072377:Syk Kinase; D051193:Toll-Like Receptors; D000099181:Dectin-1
D016207:Cytokines; D004792:Enzyme Precursors; D047908:Intracellular Signaling Peptides and Proteins; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D011505:Protein-Tyrosine Kinases; D011956:Receptors, Cell Surface; D000072377:Syk Kinase; D051193:Toll-Like Receptors; D000099181:Dectin-1