title: High-resolution 3D scaffold model for engineered tissue fabrication using a rapid prototyping technique.
abstract: Rapid prototyping, automatic image processing (computer-aided design (CAD)) and computer-aided manufacturing techniques are opening new and interesting prospects for medical devices and tissue engineering, especially for hard tissues such as bone. The development of a bone high-resolution scaffold prototype using these techniques is described. The results testify to the fidelity existing between microtomographic reconstruction and CAD. Furthermore, stereolithographic manufacturing of this scaffold, which possesses a high degree of similarity to the starting model as monitored by morphological evaluations (mean diameter 569 +/- 147 microm), represents a promising result for regenerative medicine applications.
authors.affiliation: Consorzio Interuniversitario CINECA, Bologna, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Quadrani
authors.forename: A
authors.initials: A
authors.lastname: Pasini
authors.forename: M
authors.initials: M
authors.lastname: Mattiolli-Belmonte
authors.forename: C
authors.initials: C
authors.lastname: Zannoni
authors.forename: A
authors.initials: A
authors.lastname: Tampieri
authors.forename: E
authors.initials: E
authors.lastname: Landi
authors.forename: F
authors.initials: F
authors.lastname: Giantomassi
authors.lastname: Natali
authors.forename: F
authors.initials: F
authors.lastname: Casali
authors.forename: G
authors.initials: G
authors.lastname: Biagini
authors.forename: A
authors.initials: A
authors.lastname: Tomei-Minardi
mesh_terms: D018786:Bone Substitutes; D017076:Computer-Aided Design; D017886:Durapatite; D020342:Finite Element Analysis; D006801:Humans; D023822:Tissue Engineering / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D018786:Bone Substitutes; D017886:Durapatite