title: HZE radiation effects for hereditary renal carcinomas.
abstract: Eker rat known as a model of hereditary renal carcinoma (RC) is an example of Mendelian dominantly inherited predisposition to a specific cancer in experimental animals. We investigate the effects of simulated space radiation on carcinogenesis using HIMAC. We estimated RBE from the Eker rats exposed to the heavy-ions, C (290 MeV/u) and Fe (500 MeV/u) ions, comparing to the effects of X-ray irradiation. Pregnant rats were exposed to C and Fe ions and X-rays with a single dose of 1 Gy, 2 Gy, 3 Gy on day 19 of gestation. The offspring were sacrificed at 8 weeks of age. We evaluated organ weights and tumor genesis. The weights of thymus, lung, liver, spleen were found to be no difference from the control at 1 Gy irradiation but 50% decrease at 3 Gy irradiation. We found in the irradiated animal that kidney, brain and testis were very sensitive organs of which the weight decreased to approximately 80% at 1 Gy and to 40% at 3 Gy irradiations. Based on the dose-response relationship of the radiation-induced carcinoma, averaged RBE ware calculated to be 1.1 for C-ion, 1.6 for Fe-ion.
authors.affiliation: International Space Radiation Laboratory NIRS, Chiba, Japan.
authors.forename: Taeko
authors.initials: T
authors.lastname: Nakadai
authors.forename: Kumie
authors.initials: K
authors.lastname: Nojima
authors.forename: Ikuo
authors.initials: I
authors.lastname: Kobayashi
authors.forename: Kayoko
authors.initials: K
authors.lastname: Sato
authors.forename: Nakahiro
authors.initials: N
authors.lastname: Yasuda
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Mitani
authors.forename: Okio
authors.initials: O
authors.lastname: Hino
mesh_terms: D000818:Animals; D002244:Carbon; D015197:Carcinogenicity Tests; D004195:Disease Models, Animal; D004307:Dose-Response Relationship, Radiation; D005260:Female; D020450:Heavy Ions; D007501:Iron; D007680:Kidney Neoplasms / Q000209:etiology* / Q000235:genetics; D018499:Linear Energy Transfer; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D009929:Organ Size; D010315:Particle Accelerators; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains; D014965:X-Rays
chemical_list: D002244:Carbon; D007501:Iron