Copper-catalyzed asymmetric ring opening of oxabicyclic alkenes with Grignard reagents.
[reaction: see text] Simple Grignard reagents were applied in copper-catalyzed asymmetric ring-opening reactions of oxabenzonorbornadiene derivatives using spiro phosphoramidite ligands. Excellent anti-stereoselectivities and good enantioselectivities were achieved.
Zhang
Wei
W
State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.
Wang
Li-Xin
LX
Shi
Wen-Jian
WJ
Zhou
Qi-Lin
QL