Interactions between Alzheimer's disease and cerebral ischemia--focus on inflammation.
Progressive memory impairment, beta-amyloid (Abeta) plaques associated with local inflammation, neurofibrillary tangles, and loss of neurons in selective brain areas are hallmarks of Alzheimer's disease (AD). Although beta-amyloid precursor protein (APP) and Abeta have a central role in the etiology of AD, it is not clear which forms of APP or Abeta are responsible for the neuronal vulnerability in AD brain. Brain ischemia, another cause of dementia in the elderly, has recently been recognized to contribute to the pathogenesis of AD and individuals with severe cognitive decline and possibly underlying AD are at increased risk for ischemic events in the brain. Moreover, the epsilon4 allele of apolipoprotein E (ApoE) is a risk factor for both AD and poor outcome following brain ischemia and hemorrhage. Several factors and molecular mechanisms that lower the threshold of neuronal death in models of AD have recently been described. Among these neuroinflammation seems to play an important role. The development and maturation of both AD neuropathology and ischemic lesions in the central nervous system are characterized by activation of glial cells and upregulation of inflammatory mediators. Indeed, anti-inflammatory approaches have proven to be beneficial in the prevention and treatment of AD-like neuropathology and ischemic injuries in vivo. This review summarizes some of the findings suggesting that neuronal overexpression of human APP renders the brain more vulnerable to ischemic injury and describes the factors that are involved in increased neuronal susceptibility to ischemic stroke.
Koistinaho
Milla
M
A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, Finland. milla.koistinaho@uku.fi
Koistinaho
Jari
J
D000544:Alzheimer Disease / Q000150:complications* / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D001241:Aspirin / Q000378:metabolism; D002545:Brain Ischemia / Q000150:complications* / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000378:metabolism; D009474:Neurons / Q000502:physiology*; D012307:Risk Factors
D016564:Amyloid beta-Protein Precursor; D001241:Aspirin