Silent pituitary macroadenoma co-secreting growth hormone and thyroid stimulating hormone.
Silent pituitary adenomas are a group of tumors showing heterogenous morphological features with no hormonal function observed clinically. To date no explanation has been provided as to why these tumors remain "silent". We report a case of a silent macroadenoma with both growth hormone (GH) and thyroid stimulating hormone (TSH) staining and secretion but with no clinical manifestations, in particular, the absence of features of acromegaly or hyperthyroidism. The relevant literature is reviewed.
Sen
Orhan
O
Department of Neurosurgery, Faculty of Medicine, Baskent University.
Ertorer
M Eda
ME
Aydin
M Volkan
MV
Erdogan
Bulent
B
Altinors
Nur
N
Zorludemir
Suzan
S
Guvener
Nilgun
N
D000236:Adenoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D005260:Female; D005951:Glucose Tolerance Test; D019382:Human Growth Hormone / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D019635:Neurosurgical Procedures; D010907:Pituitary Hormones / Q000097:blood; D010911:Pituitary Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000378:metabolism*
D010907:Pituitary Hormones; D019382:Human Growth Hormone; D013972:Thyrotropin