Susceptibility of inbred mouse strains to infection with three species of Metagonimus prevalent in the Republic of Korea.
Susceptibility of inbred mouse strains to Metagonimus yokogawai, Metagonimus miyatai, and Metagonimus takahashii infections was studied using BALB/c, ddY, C57BL/6J, C3H/HeN, and A/J mice, with H-2 haplotypes d, s, b, k, and a, respectively. Two hundred metacercariae were orally fed to each mouse, and the worm recovery rates (WRR), worm dimensions, and intrauterine egg numbers were measured at days 3, 7, 14, 21, and 28 postinfection (PI). On day 14 PI, the WRR of M. yokogawai was highest in ddY mice (average, 62.2%); those of M. miyatai and M. takahashii were highest in ddY (19.5%) and BALB/c mice (10.4%), respectively; worm maturation was best in C3H/HeN (M. yokogawai), C57BL/6J (M. miyatai), and ddY mice (M. takahashii). All mouse strains showed higher susceptibility to infection with M. yokogawai than with M. miyatai or M. takahashii. The results show that susceptibility of mice to Metagonimus infection varies according to mouse strain and parasite species but is suggested to be independent of the mouse H-2 haplotype.
Guk
Sang-Mee
SM
Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul 110-799, South Korea.
Park
Jin-Young
JY
Seo
Min
M
Han
Eun-Taek
ET
Kim
Jae-Lip
JL
Chai
Jong-Yil
JY
D000818:Animals; D000830:Animals, Laboratory; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D005298:Fertility; D005399:Fishes; D006239:Haplotypes; D006578:Heterophyidae / Q000254:growth & development / Q000276:immunology / Q000502:physiology*; D006790:Host-Parasite Interactions; D007723:Korea; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains / Q000469:parasitology*; D012741:Sexual Maturation; D014201:Trematode Infections / Q000276:immunology / Q000469:parasitology*