title: N-6 polyunsaturated fatty acids confer hemodynamic stability in an experimental model of multiple trauma.
abstract: Immunonutrition with diets enriched in polyunsaturated fatty acids (PUFAs) are becoming mandatory for multiple trauma patients. Solutions containing single n-6 PUFAs were administered intravenously in an experimental model of trauma. Thirty-five rabbits were studied; 13 controls; 10 administered gamma-linolenic acid (GLA) 30 min after fracture of the right femor; and 12 arachidonic acid (AA). Systolic, diastolic and mean arterial pressures and heart rate were recorded; serum levels of tumor necrosis factor-alpha (TNFalpha), malondialdehyde (MDA) and nitrate were estimated before and after therapy. Mean survival of controls, of animals treated with GLA and of animals treated with AA was 0.80, 1.41 and 3.60 days, respectively. Administration of PUFAs induced higher levels of blood pressure; that of AA decreased serum TNFalpha and tissue bacterial load compared to controls. Intravenous administration of n-6 PUFAs conferred hemodynamic stability and increased survival in a model of trauma rendering further research mandatory.
authors.affiliation: 2nd Department of Orthopaedics, University of Athens, Medical School, Greece.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Efstathopoulos
authors.forename: Efstathios
authors.initials: E
authors.lastname: Bathrellos
authors.forename: Evangelos J
authors.initials: EJ
authors.lastname: Giamarellos-Bourboulis
authors.forename: John
authors.initials: J
authors.lastname: Lazarettos
authors.forename: Apostolos
authors.initials: A
authors.lastname: Papalois
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Grecka
authors.forename: Vassilios
authors.initials: V
authors.lastname: Nikolaou
mesh_terms: D000818:Animals; D016718:Arachidonic Acid / Q000008:administration & dosage / Q000378:metabolism*; D001424:Bacterial Infections; D001794:Blood Pressure / Q000502:physiology; D004042:Dietary Fats, Unsaturated; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics; D006801:Humans; D008315:Malondialdehyde / Q000097:blood; D009104:Multiple Trauma / Q000378:metabolism* / Q000628:therapy; D009566:Nitrates / Q000097:blood; D011817:Rabbits; D015996:Survival Rate; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D017965:gamma-Linolenic Acid / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use
chemical_list: D004042:Dietary Fats, Unsaturated; D009566:Nitrates; D014409:Tumor Necrosis Factor-alpha; D016718:Arachidonic Acid; D008315:Malondialdehyde; D017965:gamma-Linolenic Acid