Synthesis and antifungal activity of 5-arylamino-4,7-dioxobenzo[b]thiophenes.
5-Arylamino-4,7-dioxobenzo[b]thiophenes 3-6 were synthesized and tested for in vitro antifungal activity against Candida and Aspergillus species. 5-Arylamino-6-chloro-2-(methoxycarbonyl)-4,7-dioxobenzo[b]thiophenes 5 showed, in general, more potent antifungal activity against Candida species than the other 4,7-dioxobenzo[b]thiophenes 3, 4 and 6. The results suggest that 5-arylamino-4,7-dioxobenzo[b]thiophenes would be potent antifungal agents.
Ryu
Chung-Kyu
CK
College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, South Korea. ckryu@mm.ewha.ac.kr
Lee
Su-Kyung
SK
Han
Ja-Young
JY
Jung
Ok-Jai
OJ
Lee
Jung Yoon
JY
Jeong
Seong Hee
SH
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000935:Antifungal Agents; D013876:Thiophenes