title: A hypothetical protein of Streptococcus mutans is critical for biofilm formation.
abstract: Inactivation of the Smu0630 gene of Streptococcus mutans resulted in dramatic decreases in biofilm formation, regardless of the carbohydrate source. The Smu0630 protein contained numerous interesting features, including a possible signal sequence and two conserved regions of repeated sequences. Smu0630 may represent a potential target for novel therapeutics.
authors.affiliation: Department of Oral Biology, University of Florida College of Dentistry, 1600 SW Archer Rd., Gainesville, FL 32610-0424, USA.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Brown
authors.forename: Sang-Joon
authors.initials: SJ
authors.lastname: Ahn
authors.forename: Roslyn N
authors.initials: RN
authors.lastname: Frank
authors.forename: Yi-Ywan M
authors.initials: YY
authors.lastname: Chen
authors.forename: José A
authors.initials: JA
authors.lastname: Lemos
authors.forename: Robert A
authors.initials: RA
authors.lastname: Burne
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D018441:Biofilms / Q000254:growth & development*; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D008855:Microscopy, Electron, Scanning; D008969:Molecular Sequence Data; D013295:Streptococcus mutans / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; C500906:Smu0630 protein, Streptococcus mutans