title: Antihepatotoxic effect of beta-carotene on paracetamol induced hepatic damage in rats.
abstract: Enzyme levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase (ALP) increased following paracetamol induction were significantly lowered due to pretreatment with the beta-carotene (BC). This supplementation reversed the trend inducing a significant decrease in bilirubin and urea levels. Paracetamol administration significantly reduced hepatic glycogen, glutathione (GSH), glutathione-S-transferase (GST), glutathione peroxidase (GPX) and glutathione reductase (GSH-R). Pretreatment of rats with BC significantly increased the enzyme activities. The results suggest hepatoprotective activity of BC.
authors.affiliation: Department of Life Science, Selvamm Arts and Science College, Namakkal, India. pgsvedhakumar@yahoo.com
authors.forename: G
authors.initials: G
authors.lastname: Kumar
authors.forename: G Sharmila
authors.initials: GS
authors.lastname: Banu
authors.forename: V
authors.initials: V
authors.lastname: Kannan
authors.forename: M Rajasekara
authors.initials: MR
authors.lastname: Pandian
mesh_terms: D000082:Acetaminophen / Q000633:toxicity*; D018712:Analgesics, Non-Narcotic / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000517:prevention & control*; D004195:Disease Models, Animal; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D019207:beta Carotene / Q000627:therapeutic use*
chemical_list: D018712:Analgesics, Non-Narcotic; D000975:Antioxidants; D019207:beta Carotene; D000082:Acetaminophen