Selected hormones levels in individuals with endothelial dysfunction and insulin resistance.
OBJECTIVE
To determine possible differences in selected serum hormones levels related to endothelial function and insulin sensitivity.


METHODS
Ghrelin, insulin, serotonin, growth hormone, IGF-1, leptin and adiponectin serum levels were determined in a group of 83 adults (40 women, 43 men) with a mean age 49.4+/-4.6 years. Total ghrelin, insulin and serotonin levels were measured using RIA, growth hormone and leptin using IRMA and human adiponectin was measured using ELISA. Results were associated with BMI, calculated as kg/ m2, endothelial function, determined by ultrasound measured flow mediated vasodilatation of brachial artery, and with insulin resistance, calculated by IR HOMA index.


RESULTS
We found no difference in age comparing subjects with (ED+) and without (ED-) endothelial dysfunction, neither comparing subject with (IR+) and without (IR-) insulin resistance. In individuals ED+ and IR+ a higher BMI, serum leptin and insulin levels and lower ghrelin, growth hormone and adiponectin levels were found. Subject with ED presented with a higher serum serotonin level compared to subjects without ED. This difference was not found in individuals with and without IR.


CONCLUSIONS
Lower ghrelin, growth hormone and adiponectin levels along with higher insulin and leptin levels may contribute to the progression of endothelial dysfunction and insulin resistance.
Tajtakova
M
M
1st Department of Internal Medicine, Safarikiensis University, Kosice, Slovakia. tajtakova@central.medic.upjs.sk
Petrovicova
J
J
Spurny
P
P
Pytliak
M
M
Petrasova
D
D
Zemberova
E
E
D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006728:Hormones / Q000097:blood*; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged
D006728:Hormones