Relationship between serum lipoprotein(a) concentrations and coronary vasomotion in coronary spastic angina.
BACKGROUND
Elevated lipoprotein(a) (Lp(a)) concentrations are reported to impair endothelium-dependent vasodilatation of the epicardial coronary artery. However, the effects on vasomotor abnormalities in coronary spastic angina (CSA) have not been thoroughly investigated.


RESULTS
In the present study 80 sites of spasm (spastic sites) without significant organic stenosis (% diameter stenosis <50%) were assessed in 80 patients with CSA diagnosed by intracoronary ergonovine (EM) test. Spastic sites were divided into 2 groups: Group 1 included 30 sites provoked by the full dose (=50 microg) of EM, and Group 2 included 50 sites provoked with less than 50 microg (34.7+/-8.2 microg). Control subjects (n=22) did not show coronary spasm with the EM test. Serum Lp(a) concentrations were measured in all patients. Group 2 had a significantly greater basal coronary artery tone in the spastic sites than Group 1 (p<0.001). Lp(a) level in Group 2 was significantly higher compared with both the control group and Group 1 (p<0.05 by analysis of variance). Multivariate analysis confirmed that only serum Lp(a) concentration was associated with low-dose EM spasm provocation.


CONCLUSIONS
Serum Lp(a) concentration could be a marker for high disease activity in CSA.
Tsuchida
Keiichi
K
Division of Cardiology, Graduate School of Medical and Dental Sciences, Niigata University. keitsuchida97@kjb.biglobe.ne.jp
Hori
Tomoyuki
T
Tanabe
Naohito
N
Makiyama
Yashiro
Y
Ozawa
Takuya
T
Saigawa
Takashi
T
Watanabe
Ritsuo
R
Tanaka
Takayuki
T
Nasuno
Akimitsu
A
Fukunaga
Hiroshi
H
Mezaki
Tohru
T
Nakamura
Yuichi
Y
Aizawa
Yoshifusa
Y
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000097:blood* / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D003329:Coronary Vasospasm / Q000097:blood* / Q000503:physiopathology; D003331:Coronary Vessels / Q000503:physiopathology; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014664:Vasodilation
D015415:Biomarkers; D017270:Lipoprotein(a)