title: Clinically diagnosed childhood asthma and follow-up of symptoms in a Swedish case control study.
abstract: BACKGROUND
  Childhood asthma has risen dramatically not only in the western societies and now forms a major and still increasing public health problem. The aims of this study were to follow up at the age of ten the patterns of asthma symptoms and associations among children with a clinically diagnosed asthma in a sizeable urban-rural community and to in compare them with demographic controls using a standardised questionnaire.
  
  
  METHODS
  In a defined region in Sweden with a population of about 150,000 inhabitants, all children (n = 2,104) born in 1990 were recorded. At the age of seven all primary care and hospital records of the 1,752 children still living in the community were examined, and a group of children (n = 191) was defined with a well-documented and medically confirmed asthma diagnosis. At the age of ten, 86 % of these cases (n = 158) and controls (n = 171) completed an ISAAC questionnaire concerning asthma history, symptoms and related conditions.
  
  
  RESULTS
  Different types of asthma symptoms were highly and significantly over-represented in the cases. Reported asthma heredity was significantly higher among the cases. No significant difference in reported allergic rhinitis or eczema as a child was found between cases and controls. No significant difference concerning social factors or environmental exposure was found between case and controls. Among the control group 4.7 % of the parents reported that their child actually had asthma. These are likely to be new asthma cases between the age of seven and ten and give an estimated asthma prevalence rate at the age of ten of 15.1 % in the studied cohort.
  
  
  CONCLUSIONS
  A combination of medical verified asthma diagnosis through medical records and the use of self-reported symptom through the ISAAC questionnaire seem to be valid and reliable measures to follow-up childhood asthma in the local community. The asthma prevalence at the age of ten in the studied birth cohort is considerably higher than previous reports for Sweden. Both the high prevalence figure and allowing the three-year lag phase for further settling of events in the community point at the complementary roles of both hospital and primary care in the comprehensive coverage and control of childhood asthma in the community.
authors.affiliation: Department of Health and Society/General Practice and Primary Care, Faculty of Health Sciences, University of Linköping, SE-581 83 Linköping, Sweden. eduardo.roel@ihs.liu.se
authors.forename: Eduardo
authors.initials: E
authors.lastname: Roel
authors.forename: Ashild
authors.initials: A
authors.lastname: Faresjö
authors.forename: Olle
authors.initials: O
authors.lastname: Zetterström
authors.forename: Erik
authors.initials: E
authors.lastname: Trell
authors.forename: Tomas
authors.initials: T
authors.lastname: Faresjö
mesh_terms: D001249:Asthma / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy*; D016022:Case-Control Studies; D002648:Child; D002662:Child Health Services / Q000458:organization & administration*; D015331:Cohort Studies; D003266:Continuity of Patient Care; D006761:Hospitals; D006801:Humans; D010290:Parents; D015995:Prevalence; D011320:Primary Health Care / Q000458:organization & administration*; D018434:Sickness Impact Profile; D011795:Surveys and Questionnaires; D013548:Sweden / Q000453:epidemiology