Dietary fibre and colorectal cancer: a model for environment--gene interactions.
As environmental factors are clearly associated with risk for colorectal cancer, we set out to model how dietary fibre, or the effects of its ingestion, might impact upon the complex events that characterise colorectal oncogenesis. The diverse nature of dietary fibre and its resultant fate in the gut is outlined. The evidence indicates that different types of fibre create different conditions in different regions of the gut. This is reflected in different effects on oncogenesis especially in animal models. Data from animal models show that insoluble fibre is protective. Evidence from human studies are not consistent, especially considering the interventional studies. However, all such studies have been dependent on biomarkers short of cancer formation, for measurement of an effect. The biological and molecular events characteristic of colorectal oncogenesis are reviewed in an effort to identify how fibre ingestion might regulate oncogenesis. While several mechanisms might account for protection, the results of fermentation and especially butyrate production provide examples of how genomic instability might be controlled. Activation of apoptosis and cell cycle arrest seem likely to be mechanisms that would enable correction of genomic events that drive oncogenesis. Butyrate itself can regulate gene expression by both epigenetic and direct effects.
Young
Graeme P
GP
Department of Medicine, Flinders University of South Australia, Bedford Park, Adelaide, Australia. graeme.young@flinders.edu.au
Hu
Ying
Y
Le Leu
Richard K
RK
Nyskohus
Laura
L
D000236:Adenoma; D000818:Animals; D017209:Apoptosis; D002087:Butyrates / Q000378:metabolism; D002273:Carcinogens; D002454:Cell Differentiation; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics* / Q000517:prevention & control; D004249:DNA Damage; D004043:Dietary Fiber / Q000008:administration & dosage; D004195:Disease Models, Animal; D004777:Environment; D005285:Fermentation; D006801:Humans; D009154:Mutation
D002087:Butyrates; D002273:Carcinogens; D004043:Dietary Fiber