Evaluation of the therapeutic response to In-111-DTPA octreotide-based targeted therapy in liver metastatic neuroendocrine tumors according to CT/MRI/US findings.
Thirteen (13) patients with liver neuroendocrine carcinomas metastases, positive for somatostatin receptors, confirmed by scintigraphy were infused with 4070-7030 MBq per session of In-111-octreotide after selective hepatic catheterization, exploiting the catastrophic activity of Indium Auger and Internal Conversion electron emission on cell DNA. Evaluation of the treatment was assessed by ultrasonography (US) as well as by computed tomography and/or magnetic resonance imaging scans. US appears to be the imaging procedure of choice because the examination is sensitive for evaluating lesions' edema and cystic components, provides precise measurement of tumor size, and is inexpensive. Degeneration US signs were classified in stage I (an echolucent rim in the periphery of the lesion), stage IIa (lesion with large cystic spaces), stage IIb (tiny cystic spaces) and stage III (absorption of the cystic component or stable cystic remnants).
Limouris
Georgios Spyridon
GS
Nuclear Medicine Division, Department of Radiology, Aretaieion Hospital, University of Athens, 115028 Athens, Greece.
Dimitropoulos
Nikolaos
N
Kontogeorgakos
Dimitrios
D
Papanikolos
Georgios
G
Koutoulidis
Vassilios
V
Hatzioannou
Achilleas
A
Mourikis
Dimitrios
D
Lyra
Maria
M
Dimitriou
Panagiotis
P
Stravaka
Anastasia
A
Vlahos
Lambros
L
D000328:Adult; D000368:Aged; D004247:DNA / Q000378:metabolism; D005260:Female; D006801:Humans; D007204:Indium / Q000494:pharmacology; D007205:Indium Radioisotopes / Q000494:pharmacology*; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000473:pathology*; D009369:Neoplasms / Q000473:pathology; D018358:Neuroendocrine Tumors / Q000532:radiotherapy*; D015282:Octreotide / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004369:Pentetic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D011877:Radionuclide Imaging; D014057:Tomography, X-Ray Computed; D014465:Ultrasonics; D014463:Ultrasonography
C497824:111In-octreotide, DTPA(0)-; D007205:Indium Radioisotopes; D007204:Indium; D004369:Pentetic Acid; D004247:DNA; D015282:Octreotide