Alkylation of natural endoperoxide G3-factor. Synthesis and antimalarial activity studies.
Alkylation of the peroxyhemiketal function is described and all synthesised endoperoxides show good antimalarial activity. New rearrangement reactions in the presence of CsCO3, and preliminary results on Fe(II) chemical reduction of the O-O bond are presented.
Najjar
Fadia
F
Laboratoire de Synthese et Physicochimie de Molecules d'Interet Biologique, UMR CNRS 5068, Universite Paul Sabatier, 118 route de Narbonne, 31062 Toulouse, France.
Gorrichon
Liliane
L
Baltas
Michel
M
André-Barrès
Christiane
C
Vial
Henri
H
D000478:Alkylation; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010545:Peroxides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects
D000962:Antimalarials; D010545:Peroxides