[Effects of acute hypoxia on expression of heat shock protein 70 in cochlea of guinea pigs].
OBJECTIVE
To investigate the changes of the expression of heat shock protein 70 (HSP70) in the cochlea of guinea pigs under acute hypoxia.


METHODS
Different degrees of acute hypoxia were imposed on guinea pigs and slices of the cochlea were examined by immunohistochemistry to detect HSP70.


RESULTS
In normal situation, HSP70 is expressed in guinea pig's cochlea, especially in spiral ganglion and Corti's organ, under acute hypoxia, this expression was strengthened, and the degree of this strengthening showed no correlation with degree of hypoxia.


CONCLUSIONS
These results suggest that acute hypoxia can strengthen the expression of HSP70 in guinea pig's cochlea, and the degree of hypoxia has no effects on the degree of this strengthening. The expression of HSP70 in the cochlea may be a kind of protection to the structure and the function of the inner ear.
Wang
Hong-nan
HN
Department of Otolarygology, The 306th Hospital of PLA, Beijing, China. whn95@yahoo.com
Wu
Wei
W
Wang
Xi-jun
XJ
Song
Jiang-shun
JS
D000818:Animals; D003051:Cochlea / Q000378:metabolism*; D015870:Gene Expression; D006168:Guinea Pigs; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis* / Q000235:genetics; D000860:Hypoxia; D051381:Rats; D013136:Spiral Ganglion / Q000378:metabolism
D018840:HSP70 Heat-Shock Proteins