Synthesis of 1,1-disubstituted-2,6-diarylcyclohexane-4-ones catalyzed by KF/basic Al2O3 under ultrasound.
1,1-Disubstituted-2,6-diarylcyclohexane-4-ones have been synthesized via double Michael addition of 1,5-diaryl-1,4-pentadien-3-one with various active methylene compounds such as dimethyl malonate, diethyl malonate, methyl cyanoacetate and ethyl cyanoacetate catalyzed by KF/basic alumina under ultrasound irradiation to give good yields within a short time.
Li
Ji-Tai
JT
Key Laboratory of Analytical Science and Technology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, PR China. orgsyn@mail.hbu.edu.cn
Xu
Wen-Zhi
WZ
Chen
Guo-Feng
GF
Li
Tong-Shuang
TS