title: Pleomorphic giant cell carcinoma of the prostate.
abstract: We report the clinical and pathologic features of 2 cases of pleomorphic giant cell carcinoma of the prostate. One case was found at autopsy in a 77-year-old man and was composed of high-grade prostatic adenocarcinoma with prominent anaplastic giant cells. The patient presented with metastases to multiple retroperitoneal lymph nodes, liver, and lumbar vertebrae. The second case occurred in a 45-year-old man who underwent transurethral resection of the prostate and was found to have high-grade prostatic adenocarcinoma with an extensive anaplastic giant cell component. The patient presented with distant metastases and died within 9 months. Both regular adenocarcinoma and anaplastic giant tumor cells displayed cytoplasmic immunoreactivity for prostate-specific antigen, prostatic acid phosphatase, and keratin AE1/AE3; in one case, scattered cells were also positive for chromogranin and epithelial membrane antigen. Pleomorphic giant cell carcinoma is a rare variant of prostatic adenocarcinoma with a poor prognosis that should be considered in the differential diagnosis of prostatic pleomorphic tumors.
authors.affiliation: Department of Pathology, Cordoba University Medical School, Cordoba, Spain. em1lobea@uco.es
authors.forename: Antonio
authors.initials: A
authors.lastname: Lopez-Beltran
authors.forename: John N
authors.initials: JN
authors.lastname: Eble
authors.forename: David G
authors.initials: DG
authors.lastname: Bostwick
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary* / Q000601:surgery; D000368:Aged; D001859:Bone Neoplasms / Q000556:secondary; D018286:Carcinoma, Giant Cell / Q000175:diagnosis / Q000556:secondary; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D015726:Giant Cells / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008159:Lumbar Vertebrae / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000556:secondary; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery; D012187:Retroperitoneal Space