title: Molecular genetic tumor markers in non-small cell lung cancer.
abstract: Not only serum tumor markers, such as carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC) and carbohydrate antigen (CA) 125, but also serum growth factors have been examined to evaluate tumor stages and to predict the recurrence and metastasis in patients with non-small cell lung cancer (NSCLC) (1-5). In recent years, the analysis of the genome and proteome has advanced remarkably. An array of molecular genetic tumor markers (MGTMs) have been identified based on the biological characterization of tumors, such as tumor development, growth, invasion and metastasis. Molecular genetic tumor marker research has also entered a new era, since comprehensive gene profile analysis using cDNA microarrays and comprehensive protein expression analysis using proteomics technology have been developed. On the other hand, the frequency of lung cancer patients with which various tumor markers are associated is increasing in Japan (6-8). This paper reviews MGTMs characteristic of lung cancer and clarifies the clinical usefulness and applications of MGTM for cancer treatment.
authors.affiliation: Department of Surgery II and Environmental Health, University of Occupational and Environmental Health, Kitakyushu, Japan. oyama@med.uoeh-u.ac.jp
authors.forename: Tsunehiro
authors.initials: T
authors.lastname: Oyama
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Osaki
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Baba
authors.forename: Yoshika
authors.initials: Y
authors.lastname: Nagata
authors.forename: Makiko
authors.initials: M
authors.lastname: Mizukami
authors.forename: Tetsuya
authors.initials: T
authors.lastname: So
authors.forename: Shoji
authors.initials: S
authors.lastname: Nakata
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Ichiki
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Uramoto
authors.forename: Masakazu
authors.initials: M
authors.lastname: Sugaya
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshimatsu
authors.forename: Masaru
authors.initials: M
authors.lastname: Morita
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hanagiri
authors.forename: Kenji
authors.initials: K
authors.lastname: Sugio
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kawamoto
authors.forename: Kosei
authors.initials: K
authors.lastname: Yasumoto
mesh_terms: D014408:Biomarkers, Tumor; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000235:genetics; D020869:Gene Expression Profiling; D018390:Gene Targeting; D016147:Genes, Tumor Suppressor; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000235:genetics; D009362:Neoplasm Metastasis; D009857:Oncogenes
chemical_list: D014408:Biomarkers, Tumor