The crystal structure of a cyclic glycolipid reveals a carbohydrate-carbohydrate interaction interface.
The crystal structure of an amphiphilic macrocycle [Velasco-Torrijos, T.; Murphy, P. V., Tetrahedron: Asymmetry2005, 16, 261-272] derived from saccharides shows extensive hydrogen-bonding networks, including participation of water, that may have relevance for the modelling of carbohydrate-carbohydrate recognition at cell-cell interfaces. The structure may provide a basis for understanding the binding of the macrocycle to hydrophobic probes.
Murphy
Paul V
PV
Centre for Synthesis and Chemical Biology, Department of Chemistry, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland. paul.v.murphy@ucd.ie
Müller-Bunz
Helge
H
Velasco-Torrijos
Trinidad
T
D002241:Carbohydrates / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006017:Glycolipids / Q000737:chemistry*; D047028:Macrocyclic Compounds / Q000737:chemistry; D015394:Molecular Structure
D002241:Carbohydrates; D006017:Glycolipids; D047028:Macrocyclic Compounds