title: The effects of body weight on airway calibre.
abstract: Increased wheeze and asthma diagnosis in obesity may be due to reduced lung volume with subsequent airway narrowing. Asthma (wheeze and airway hyperresponsiveness), functional residual capacity (FRC) and airway conductance (Gaw) were measured in 276 randomly selected subjects aged 28-30 yrs. Data were initially adjusted for smoking and asthma before examining relationships between weight and FRC (after adjustment for height), and between body mass index (BMI = weight.height(-2)) and Gaw (after adjustment for FRC) by multiple linear regression, separately for females and males. For males and females, BMI (+/-95% confidence interval) was 27.0+/-4.6 kg.m(-2) and 25.6+/-6.0 kg.m(-2) respectively, Gaw was 0.64+/-0.04 L.s(-1).cmH2O(-1) and 0.57+/-0.03 L.s(-1).cmH2O(-1), and FRC was 85.3+/-3.4 and 84.0+/-2.9% of predicted. Weight correlated independently with FRC in males and females. BMI correlated independently and inversely with Gaw in males, but only weakly in females. In conclusion, obesity is associated with reduced lung volume, which is linked with airway narrowing. However, in males, airway narrowing is greater than that due to reduced lung volume alone. The mechanisms causing airway narrowing and sex differences in obesity are unknown.
authors.affiliation: Woolcock Institute of Medical Research, Dept of Respiratory Medicine, Royal North Shore Hospital, Pacific Highway, St. Leonards 2065, Australia. ggk@woolcock.org.au
authors.forename: G G
authors.initials: GG
authors.lastname: King
authors.forename: N J
authors.initials: NJ
authors.lastname: Brown
authors.forename: C
authors.initials: C
authors.lastname: Diba
authors.forename: C W
authors.initials: CW
authors.lastname: Thorpe
authors.forename: P
authors.initials: P
authors.lastname: Muñoz
authors.forename: G B
authors.initials: GB
authors.lastname: Marks
authors.forename: B
authors.initials: B
authors.lastname: Toelle
authors.forename: K
authors.initials: K
authors.lastname: Ng
authors.forename: N
authors.initials: N
authors.lastname: Berend
authors.forename: C M
authors.initials: CM
authors.lastname: Salome
mesh_terms: D000328:Adult; D000402:Airway Obstruction / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D001249:Asthma / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D015992:Body Mass Index; D001835:Body Weight; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008176:Lung Volume Measurements; D008297:Male; D015999:Multivariate Analysis; D009517:New South Wales / Q000453:epidemiology; D012044:Regression Analysis; D012135:Respiratory Sounds / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D017678:Sex Distribution