Post-assembly peptide modifications by chemical methods.
The demand for peptide drugs is increasing and in this context, "post-assembly (or post-translational) peptide modification strategies" by chemical manipulation of intact oligo-peptides has provided several analogues. Compounds prepared by this method are useful therapeutic molecules for structure activity studies. Herein, we describe various chemical methods such as cross-coupling reactions, cycloaddition reactions, radical reactions and ring-closing metathesis reactions that are useful for post-translational peptide modifications.
Kotha
Sambasivarao
S
Department of Chemistry, Indian Institute of Technology-Bombay, Powai, Mumbai 400 076, India. srk@chem.iitb.ac.in
Lahiri
Kakali
K
D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis* / Q000737:chemistry*
D009842:Oligopeptides; D004364:Pharmaceutical Preparations