title: Xerostomia following radiotherapy of the head and neck affects vocal function.
abstract: OBJECTIVE
  To investigate whether xerostomia induced by wide-field radiotherapy (RT) of the head and neck affects vocal function.
  
  
  METHODS
  We conducted a retrospective cohort study comparing 20 patients with early glottic cancer treated by limited RT of the larynx to 20 patients receiving wide-field RT of the primary tumor site and the lymphatic system of the entire head and neck, including the salivary glands. Salivary and vocal functions, as well as responses to questionnaires on xerostomia and quality of life were compared between groups. Twenty healthy volunteers matched for age, sex, and smoking status were included as controls.
  
  
  RESULTS
  The wide-field RT patients showed high xerostomia-related symptom scores and significantly lower values of whole salivary flow rate compared to the limited RT and healthy patients (P < .001). Subjective vocal dysfunction and stroboscopic abnormality were observed in the wide-field RT group (P < .05), but acoustic or aerodynamic profiles showed no significant difference among groups (P > .05). Subjective and objective salivary gland hypofunction was significantly correlated to vocal dysfunction.
  
  
  CONCLUSIONS
  Our results suggest that xerostomia following extensive RT of the head and neck can affect vocal function. In the treatment of head and neck malignancies, efforts to prevent post-RT xerostomia would be anticipated to contribute to the preservation of vocal function.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Chungnam National University Hospital, 640 Daesa-Dong, Chung-Gu, Daejeon, 301-040, Republic of Korea. rohjl@cnu.ac.kr
authors.forename: Jong-Lyel
authors.initials: JL
authors.lastname: Roh
authors.forename: Ah-Young
authors.initials: AY
authors.lastname: Kim
authors.forename: Moon June
authors.initials: MJ
authors.lastname: Cho
mesh_terms: D000368:Aged; D015331:Cohort Studies; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000150:complications*; D012189:Retrospective Studies; D014832:Voice Disorders / Q000209:etiology*; D014987:Xerostomia / Q000150:complications* / Q000209:etiology*