[Expression and significance of PTEN and nm23 in the metastasis of gallbladder cancer].
OBJECTIVE
To explore the relationship between the expressions of PTEN and the metastasis of the gallbladder cancer.


METHODS
The expression of PTEN and nm23 were detected by immunohistochemical staining in 32 cases of gallbladder cancer with metastasis and the staining intensity was scored semi-quantitatively, compared with the cases without metastasis.


RESULTS
The intensity score of PTEN and nm23 in gallbladder cancer with metastasis was 8.9947+/-4.5590 and 10.2003+/-3.9031, respectively, which was lower than that in those without metastasis (12.9433+/-4.7618 and 15.8436+/-5.6917 respectively, P < 0.01 ). The expression of PTEN was correlative with that of nm23 ( Pearson = 0.370, P < 0.05).


CONCLUSIONS
The lower expressions of PTEN and nm23 are related to the metastasis of gallbladder cancer.
Zheng
Chang-Li
CL
Department of Pathology, Xiangya School of Medicine, Central South University, Changsha 410078, China.
Wen
Ji-Fang
JF
Huang
Ying
Y
D005260:Female; D005706:Gallbladder Neoplasms / Q000378:metabolism*; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000556:secondary*; D008207:Lymphatic Metastasis; D008297:Male; D054778:NM23 Nucleoside Diphosphate Kinases; D009701:Nucleoside-Diphosphate Kinase / Q000096:biosynthesis* / Q000235:genetics; D051059:PTEN Phosphohydrolase / Q000096:biosynthesis* / Q000235:genetics; D025521:Tumor Suppressor Proteins / Q000096:biosynthesis / Q000235:genetics
D054778:NM23 Nucleoside Diphosphate Kinases; D025521:Tumor Suppressor Proteins; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human