The effect of noninherited maternal antigens in allogeneic transplantation.
Confrontation of the unborn child immune system with the noninherited maternal antigens (NIMAs) has a lifelong modulating impact on the immune response of the child against the NIMAs. In this review we summarize the clinical evidence for the existence of the NIMA effect, discuss the possible cellular and molecular basis of the phenomenon, and outline the necessity of further clinical research.
van Rood
J J
JJ
Europdonor Foundation, Plesmanlaan 1b, 2333 BZ Leiden, The Netherlands. vanrood@europdonor.nl
Roelen
D L
DL
Claas
F H J
FH
D000941:Antigens / Q000235:genetics / Q000276:immunology*; D005260:Female; D006086:Graft vs Host Disease / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008297:Male; D008431:Maternal-Fetal Exchange / Q000235:genetics / Q000276:immunology*; D011247:Pregnancy; D035781:Siblings; D033581:Stem Cell Transplantation; D014184:Transplantation, Homologous
D000941:Antigens