title: Structure-activity relationships of arylbenzofuran H3 receptor antagonists.
abstract: An SAR study of histamine H3 receptor antagonists based on substituted (R)-2-methyl-1-[2-(5-phenyl-benzofuran-2-yl)-ethyl]-pyrrolidines is presented.
authors.affiliation: Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA. greg.gfesser@abbott.com
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Gfesser
authors.forename: Ramin
authors.initials: R
authors.lastname: Faghih
authors.forename: Youssef L
authors.initials: YL
authors.lastname: Bennani
authors.forename: Michael P
authors.initials: MP
authors.lastname: Curtis
authors.forename: Timothy A
authors.initials: TA
authors.lastname: Esbenshade
authors.forename: Arthur A
authors.initials: AA
authors.lastname: Hancock
authors.forename: Marlon D
authors.initials: MD
authors.lastname: Cowart
mesh_terms: D001572:Benzofurans / Q000737:chemistry* / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D011759:Pyrrolidines / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D018100:Receptors, Histamine H3 / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D001572:Benzofurans; D006634:Histamine H1 Antagonists; D011759:Pyrrolidines; D018100:Receptors, Histamine H3; C105430:benzofuran