title: Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate.
abstract: Humans appear to be refractory to some effects of peroxisome proliferators including alterations in cell proliferation, whereas rodents are susceptible. In this study, differences between the human and rat response to peroxisome proliferators were evaluated using rat and human tumour liver cell lines. Rat 7777 cells were more responsive than human HepG2 cells to ciprofibrate as they exhibited a higher decrease in cell number than HepG2, and underwent apoptosis. Results from these studies reveal a surprising response in tumour cell lines as the typical in vivo response of increased cell proliferation and reduced apoptosis was not observed in rat tumour cell lines at concentrations greater than those used to elicit the former response.
authors.affiliation: Laboratoire de Biologie Moléculaire et Cellulaire (EA 2978-GDR-CNRS No. 2583), Faculté des Sciences Gabriel, Université de Bourgogne, 6, bd Gabriel 21000 Dijon, France.
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Clemencet
authors.forename: Giuliana
authors.initials: G
authors.lastname: Muzio
authors.forename: Antonella
authors.initials: A
authors.lastname: Trombetta
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Peters
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Gonzalez
authors.forename: Rosa A
authors.initials: RA
authors.lastname: Canuto
authors.forename: Norbert
authors.initials: N
authors.lastname: Latruffe
mesh_terms: D000818:Animals; D017209:Apoptosis; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects*; D002995:Clofibric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D058607:Fibric Acids; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008099:Liver / Q000166:cytology*; D051381:Rats
chemical_list: D058607:Fibric Acids; D000960:Hypolipidemic Agents; D002995:Clofibric Acid; C019304:ciprofibrate