title: Interstitial lung disease and xerostomia as initial manifestations in a patient with human immunodeficiency virus infection.
abstract: A 56-year-old human immunodeficiency virus (HIV)-infected man presented with progressive interstitial lung disease (ILD) and lymphocyte infiltration of the salivary glands which mimicked autoimmune disease. Pneumonia, which was very likely caused by Pneumocystis carinii, developed after 3 courses of monthly methylprednisolone pulse therapy for ILD. Both enzyme immunoassay and Western blot analysis confirmed the HIV infection. After antibiotic treatment, the pneumonia gradually resolved. Autoimmune manifestations such as ILD and xerostomia may be initial presentations of HIV infection. Immunosuppressive drugs must be used cautiously in these patients. Screening for HIV is mandatory in the differential diagnosis of patients with ILD or xerostomia.
authors.affiliation: Division of Allergy, Immunology and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Seng Eng
authors.initials: SE
authors.lastname: Ooi
authors.forename: Chang Youh
authors.initials: CY
authors.lastname: Tsai
authors.forename: Chung Tei
authors.initials: CT
authors.lastname: Chou
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D011020:Pneumonia, Pneumocystis / Q000150:complications; D013624:Taiwan; D014987:Xerostomia / Q000150:complications* / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone