title: Ovarian cysts in tamoxifen-treated women with breast cancer.
abstract: OBJECTIVE
  The objective of this study was to detect any ovarian changes in tamoxifen-treated breast cancer patients.
  
  
  METHODS
  In all, 51 patients with breast cancer were enrolled in the study, which was conducted in the SSK (Social Security Agency) Aegean Maternity Hospital between January 1999 and December 2002. The patients' demographic and medical data were reviewed. All patients taking part in the study received tamoxifen therapy, but the duration was not uniform. Gynecological examination and transvaginal ultrasonography (TVU) were performed in each case. Any ovarian cysts or masses were identified, and serum Ca-125 levels were recorded.
  
  
  RESULTS
  Of the 51 tamoxifen-treated patients enrolled in this study, 24 were still premenopausal and 27 were postmenopausal when they were monitored for breast cysts during the tamoxifen treatment started after the diagnosis of breast cancer. Their average age was 53.7 (range 31-64) years. The mean duration of tamoxifen therapy was 23.5 (range 8-49) months. Ovarian cysts were diagnosed in nine (17.6%) patients and required surgery in two of these; pathological examination revealed serous cysts of the ovary in both.
  
  
  CONCLUSIONS
  : In cases with ovarian cyst formation during tamoxifen treatment of breast cancer, discontinuation of tamoxifen followed by monitoring is quite a reasonable way to proceed in most cases. Surgical intervention should be carried out when cysts are >5 cm in diameter.
authors.affiliation: Social Security Agency, Aegean Maternity Hospital, 3rd clinics of Obstetrics and Gynecology, Gaz, Izmir, Turkey. inal121@hotmail.com
authors.forename: M Murat
authors.initials: MM
authors.lastname: Inal
authors.forename: Adnan
authors.initials: A
authors.lastname: Incebiyik
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Sanci
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Yildirim
authors.forename: Mesut
authors.initials: M
authors.lastname: Polat
authors.forename: Bariş
authors.initials: B
authors.lastname: Pilanci
authors.forename: Cenk
authors.initials: C
authors.lastname: Nayki
authors.forename: Hakan
authors.initials: H
authors.lastname: Camuzcuoğlu
mesh_terms: D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010048:Ovarian Cysts / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D017698:Postmenopause; D017697:Premenopause; D011446:Prospective Studies; D013629:Tamoxifen / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen