title: Fluorescence imaging of tumors in vivo.
abstract: We review recent progress in tumor imaging in vivo using fluorescent tags, highlight the problems of fluorescence imaging in small animals, discuss recent advances in near-infrared fluorochromes and quantum dots, and point to some future possibilities. GFP-based fluorescence imaging is briefly discussed. The authors believe that improvements in near-infrared fluorochromes are required to enable practical imaging in tissues at centimeter depths.
authors.affiliation: Molecular Biosensor and Imaging Center, Department of Biology, Carnegie Mellon University, Pittsburgh, PA 15213, USA. bbal@andrew.cmu.edu
authors.forename: Byron
authors.initials: B
authors.lastname: Ballou
authors.forename: Lauren A
authors.initials: LA
authors.lastname: Ernst
authors.forename: Alan S
authors.initials: AS
authors.lastname: Waggoner
mesh_terms: D000818:Animals; D003952:Diagnostic Imaging / Q000379:methods*; D005456:Fluorescent Dyes / Q000737:chemistry; D051379:Mice; D015335:Molecular Probes / Q000737:chemistry; D015394:Molecular Structure; D009369:Neoplasms / Q000175:diagnosis*; D045663:Quantum Dots; D013050:Spectrometry, Fluorescence / Q000379:methods*; D019265:Spectroscopy, Near-Infrared / Q000379:methods
chemical_list: D005456:Fluorescent Dyes; D015335:Molecular Probes