Iron-catalyzed homo-coupling of simple and functionalized arylmagnesium reagents.
Iron-catalyzed homo-coupling of simple and functionalized arylmagnesium reagents is described. The reaction is highly chemoselective (CN, COOEt and NO(2) groups are tolerated). The procedure was used to perform intramolecular couplings. This cyclization reaction is the key step of the total synthesis of the N-methylcrinasiadine.
Cahiez
Gérard
G
Laboratoire de Synthèse Organique Sélective et de Chimie Organométallique (SOSCO), UMR 8123 CNRS-UCP-ESCOM, Cergy-Pontoise, France. gerard.cahiez@chim-u.cergy.fr
Chaboche
Christophe
C
Mahuteau-Betzer
Florence
F
Ahr
Mathieu
M
D002384:Catalysis; D003500:Cyclization; D006576:Heterocyclic Compounds, 4 or More Rings / Q000032:analysis / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D007501:Iron / Q000737:chemistry*; D019668:Liliaceae / Q000737:chemistry; D008274:Magnesium / Q000737:chemistry*; D015394:Molecular Structure
D006576:Heterocyclic Compounds, 4 or More Rings; D007202:Indicators and Reagents; C507777:N-methylcrinasiadine; D007501:Iron; D008274:Magnesium