Effects of COMT genotype on behavioral symptomatology in the 22q11.2 Deletion Syndrome.
The 22q11.2 Deletion Syndrome (DiGeorge/velocardiofacial syndrome) is associated with elevated rates of psychosis, and is also characterized by severe attentional difficulties and executive dysfunction. Behavioral manifestations of this syndrome could result from haploinsufficiency of the catechol-O-methyltransferase (COMT) gene, located within the 22q11 region. The goal of the present study was to examine COMT genotype in relation to behavioral symptomatology in this syndrome. Val158/108Met was genotyped in 38 patients (16 Met/-, 22 Val/-) with confirmed 22q11.2 deletions who had received the Child Behavior Checklist (CBCL) as part of a comprehensive evaluation. Results indicated that the Val genotype was associated with significantly greater internalizing and externalizing behavioral symptomatology in children with 22q11.2 deletions. Val allele status was associated with a greater-than-four-fold increase in risk for clinically significant behavior problems in children with this syndrome. These data are consistent with previous findings of increased psychopathology associated with the Val genotype in normal individuals and suggest that a functional genetic polymorphism in the 22q11 region may influence behavior in individuals with COMT haploinsufficiency.
Bearden
Carrie E
CE
Department of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA. CBearden@mednet.ucla.edu
Jawad
Abbas F
AF
Lynch
David R
DR
Monterossso
John R
JR
Sokol
Set
S
McDonald-McGinn
Donna M
DM
Saitta
Sulagna C
SC
Harris
Stacy E
SE
Moss
Edward
E
Wang
Paul P
PP
Zackai
Elaine
E
Emanuel
Beverly S
BS
Simon
Tony J
TJ
D002394:Catechol O-Methyltransferase / Q000235:genetics* / Q000378:metabolism*; D002648:Child; D002653:Child Behavior Disorders / Q000175:diagnosis / Q000209:etiology / Q000235:genetics*; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D004062:DiGeorge Syndrome / Q000201:enzymology* / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics; D012720:Severity of Illness Index
D002394:Catechol O-Methyltransferase