title: Serum selenoprotein-P levels in patients with inflammatory bowel disease.
abstract: OBJECTIVE
  Selenoprotein-P is a selenium-rich serum protein that carries more than 50% of serum selenium. We evaluated changes in serum selenoprotein-P levels in patients with inflammatory bowel disease.
  
  
  METHODS
  Serum selenoprotein-P levels were measured by enzyme-linked immunosorbent assay. Twenty healthy individuals (controls), 34 patients with ulcerative colitis, and 37 patients with Crohn's disease (CD) were studied.
  
  
  RESULTS
  A highly significant correlation was found between the serum selenium and selenoprotein-P levels. There was no significant difference in serum selenoprotein-P levels between healthy controls (average 3.4+/-0.8 microg/mL, n=20) and patients with ulcerative colitis (3.0+/-1.0 microg/mL, n=34). Serum selenoprotein-P levels were significantly lower in patients with CD (average 1.8+/-0.5 microg/mL, n=37). Serum selenoprotein-P levels were significantly lower in the elemental diet group of patients who had CD (average 1.4+/-0.4 microg/mL, n=17) than in the non-elemental diet group of patients who had CD (average 2.1+/-0.3 microg/mL, n=20).
  
  
  CONCLUSIONS
  We found that the serum selenoprotein-P level is decreased in patients with CD. It may be a useful marker to monitor the systemic selenium status in various disorders.
authors.affiliation: Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan. andoh@belle.shiga-med.ac.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Andoh
authors.forename: Masaki
authors.initials: M
authors.lastname: Hirashima
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Maeda
authors.forename: Kazunori
authors.initials: K
authors.lastname: Hata
authors.forename: Osamu
authors.initials: O
authors.lastname: Inatomi
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Tsujikawa
authors.forename: Masaya
authors.initials: M
authors.lastname: Sasaki
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Takahashi
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Fujiyama
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000097:blood; D003424:Crohn Disease / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000097:blood*; D008297:Male; D009752:Nutritional Status; D011506:Proteins / Q000378:metabolism*; D012643:Selenium / Q000097:blood*; D051149:Selenoprotein P; D051140:Selenoproteins; D013054:Spectrophotometry, Atomic / Q000379:methods
chemical_list: D011506:Proteins; D051149:Selenoprotein P; D051140:Selenoproteins; D012643:Selenium