Stochastic modeling of protein motions within cell membranes.
A simple model in which immobilizing events are imposed onto otherwise free Brownian diffusion [R. Metzler and J. Klafter, Phys. Rep. 339, 1 (2000) and a recent adaptation due to S. Khan and A. M. Reynolds, Physica A 350, 183 (2005)] is shown to encapsulate the peculiar transport characteristics of individual cell receptors within plasma membranes observed in single-particle tracking (SPT) experiments. These characteristics include the occurrence of normal diffusion; non-Gaussian subdiffusion; confined diffusion; a superdiffusive mode of transport that is not due to flow of the membrane or molecular motor attachment; and the occurrence of transitions between these transport modes. Model predictions are shown to be in close agreement with a reanalysis of existing SPT data.
Khan
Sharon
S
Rothamsted Research, Harpenden, Hertfordshire AL5 2LQ, United Kingdom.
Reynolds
Andy M
AM
Morrison
Ian E G
IE
Cherry
Richard J
RJ
D001692:Biological Transport; D002462:Cell Membrane / Q000737:chemistry*; D003198:Computer Simulation; D004058:Diffusion; D006680:HLA Antigens / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008954:Models, Biological; D008956:Models, Chemical; D015233:Models, Statistical; D009038:Motion; D021381:Protein Transport; D011506:Proteins / Q000737:chemistry*; D013269:Stochastic Processes
D006680:HLA Antigens; D011506:Proteins