Antidiabetic and antihyperlipemic effects of Clemeo felina.
Petroleum ether and benzene extracts of Clemeo felina, given orally at doses of 300 mg kg(-1) day(-1) for 30 days, were found to be antidiabetic and antihyperlipemic on alloxan diabetic rats. Moreover, a significant decrease in the activities of serum enzymes like alkaline phosphatase, acid phosphatase and HMGCoA reductase activity in the liver was observed. However, treatment of rats with the extracts as well as standard antidiabetic drugs increased liver hexakinase activity and serum LDH activity.
Nagarajan
N S
NS
Department of Chemistry, Gandhigram Rural Institute, Deemed University, Gandhigram 624 302, Tamil Nadu, India. nsndgj@yahoo.co.in
Murugesh
N
N
Thirupathy Kumaresan
P
P
Radha
N
N
Murali
A
A
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D005905:Glyburide / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D007328:Insulin; D010936:Plant Extracts; D005905:Glyburide