First-pass metabolism of ethanol in human beings: effect of intravenous infusion of fructose.
Intravenous infusion of fructose has been shown to enhance reduced form of nicotinamide adenine dinucleotide reoxidation and, thereby, to enhance the metabolism of ethanol. In the current study, the effect of fructose infusion on first-pass metabolism of ethanol was studied in human volunteers. A significantly higher first-pass metabolism of ethanol was obtained after administration of fructose in comparison with findings for control experiments with an equimolar dose of glucose. Because fructose is metabolized predominantly in the liver and can be presumed to have virtually no effects in the stomach, results of the current study support the assumption that only a negligible part of first-pass metabolism of ethanol occurs in the stomach.
Parlesak
Alexandr
A
Department of Physiology of Nutrition, Hohenheim University (140e), Garbenstrasse 28, 70599 Stuttgart, Germany. parlesak@uni-hohenheim.de
Billinger
Michael Hans-Ulrich
MH
Schäfer
Christian
C
Wehner
Heinz-Dieter
HD
Bode
Christiane
C
Bode
Johann Christian
JC
D000328:Adult; D000818:Animals; D000431:Ethanol / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism*; D005632:Fructose / Q000008:administration & dosage*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D005632:Fructose; D000431:Ethanol