title: Xanthones from Garcinia smeathmannii (Oliver) and their antimicrobial activity.
abstract: Two new xanthones, smeathxanthone A (1) (2-(3,7-dimethyl-2,6-octadienyl)-1,3,5,8-tetrahydroxyxanthone) and smeathxanthone B (2) (5,7,10-trihydroxy-2-methyl-2-(4-methylpent-3-enyl)[2H, 6H]pyrano[3,2-b]xanthen-6-one), have been isolated from the stem bark of Garcinia smeathmannii, and their structures elucidated on the basis of 1D and 2D NMR experiments. 1,3,5-Trihydroxyxanthone and 1,5-dihydroxyxanthone were also obtained. The compounds showed only modest activity against a range of bacteria and yeasts.
authors.affiliation: Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
authors.forename: Justin
authors.initials: J
authors.lastname: Komguem
authors.forename: A L
authors.initials: AL
authors.lastname: Meli
authors.forename: R N
authors.initials: RN
authors.lastname: Manfouo
authors.forename: David
authors.initials: D
authors.lastname: Lontsi
authors.forename: F N
authors.initials: FN
authors.lastname: Ngounou
authors.forename: V
authors.initials: V
authors.lastname: Kuete
authors.forename: Hippolyte W
authors.initials: HW
authors.lastname: Kamdem
authors.forename: Pierre
authors.initials: P
authors.lastname: Tane
authors.forename: Bonaventure T
authors.initials: BT
authors.lastname: Ngadjui
authors.forename: Beiban L
authors.initials: BL
authors.lastname: Sondengam
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Connolly
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D029760:Garcinia / Q000737:chemistry*; D015394:Molecular Structure; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C505174:2-(3,7-dimethyl-2,6-octadienyl)-1,3,5,8-tetrahydroxyxanthone; C505173:5,7,10-trihydroxy-2-methyl-2-(4-methylpent-3-enyl)(2H,6H)pyrano(3,2-b)xanthen-6-one; D000890:Anti-Infective Agents; D044004:Xanthones