[Effect of shexiang baoxin pill in alleviating myocardial fibrosis in spontaneous hypertensive rats].
OBJECTIVE
To investigate the effects and mechanisms of Shexiang Baoxin Pill (SBP) on myocardial fibrosis in spontaneous hypertensive rats (SHR).


METHODS
SHR of 12 weeks old were divided into the SBP group, the control group (treated with benazepril) and the model control group. The effects on such indexes as systolic blood pressure (SBP), left ventricular mass (LVM), left ventricular mass index (LVMI), content of myocardial collagen (MC) in left ventricle, extracellular matrix fibronectin (FN), laminin (LN), cardiac fibroblast (cFb) and transforming growth factor-beta1 (TGF-beta1) were determined after 12 weeks of treatment.


RESULTS
SBP had no marked pressure depressive effect, but had the effect similar to that of benazepril in reducing the level of LVM, LVMI and content of MC (P < 0.05), as well as the content of LN, FN in myocardium, cFb count and TGF-beta1 expression (P < 0.05).


CONCLUSIONS
SBP can prevent and treat myocardial fibrosis, whose action is independent of its hypotensive effect. The mechanism may be associated with such factors as the decrease of MC synthesis in left ventricle and the deposition of extracellular matrix.
Wu
Duo-Jiao
DJ
Department of Cardiovascular Diseases, Institute of Coronary Heart Disease, Union Hospital, Fujian Medical University, Fuzhou.
Hong
Hua-Shan
HS
Jiang
Qiong
Q
D000818:Animals; D003094:Collagen / Q000096:biosynthesis; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005355:Fibrosis / Q000517:prevention & control; D006973:Hypertension / Q000188:drug therapy / Q000473:pathology*; D017379:Hypertrophy, Left Ventricular / Q000517:prevention & control; D008297:Male; D009206:Myocardium / Q000473:pathology*; D008517:Phytotherapy; D011897:Random Allocation; D051381:Rats; D011918:Rats, Inbred SHR; D016212:Transforming Growth Factor beta / Q000096:biosynthesis / Q000235:genetics; D053773:Transforming Growth Factor beta1
D004365:Drugs, Chinese Herbal; C508962:Tgfb1 protein, rat; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D003094:Collagen