Preliminary study on inhibition of genotoxicity by piperine in mice.
A significant suppression (33.9-66.5%) in the micronuclei formation induced by benzo(a)pyrene and cyclophosphamide was reduced following oral administration of piperine at doses of 25, 50 and 75 mg/kg in mice.
Selvendiran
K
K
Department of Medical Biochemistry, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India. selvakphd@yahoo.com
Padmavathi
R
R
Magesh
V
V
Sakthisekaran
D
D
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001564:Benzo(a)pyrene / Q000037:antagonists & inhibitors; D052117:Benzodioxoles; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects*; D010880:Piperidines / Q000494:pharmacology*; D053284:Polyunsaturated Alkamides
D000470:Alkaloids; D016587:Antimutagenic Agents; D052117:Benzodioxoles; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D001564:Benzo(a)pyrene; D003520:Cyclophosphamide; C008922:piperine