[Research progress of the drug-coated stents].
Emplacing a stent in the coronary artery has many characteristics. The installation is easy to do and the stent has evident curative effect. However, it will cause thrombosis and immunoreaction because it is metal. So suburgent thrombosis and restenosis after surgeries are still two major complications. The drug-coated stent is one kind of the drug-eluting stents, whose metal surface is coated by some polymer that combines with a sort of effective drug or antibody. It can transport the drug or antibody to the localily of pathological changes and there in it improves the local drug concentration. In this paper the research progress of interrelated issues about the drug-coated stent is reviewed.
Yin
Tieying
T
Key Lab. of Biomechanics & Tissue Engineering under the State Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China.
Wang
Guixue
G
D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation; D020099:Coated Materials, Biocompatible; D023903:Coronary Restenosis / Q000517:prevention & control*; D016503:Drug Delivery Systems / Q000295:instrumentation*; D006801:Humans; D019344:Lactic Acid / Q000008:administration & dosage; D017239:Paclitaxel / Q000008:administration & dosage; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011091:Polyesters; D011108:Polymers / Q000008:administration & dosage; D020123:Sirolimus / Q000008:administration & dosage; D015607:Stents / Q000009:adverse effects*
D020099:Coated Materials, Biocompatible; D004364:Pharmaceutical Preparations; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D017239:Paclitaxel; D020123:Sirolimus