title: Proton magnetic resonance spectroscopy and diffusion-weighted imaging of central nervous system whipple disease.
abstract: A 72-year-old man presented with a 6-month history of dysphagia, fatigue, 60-lb weight loss, and central nervous system (CNS) deficits. Diffusion-weighted magnetic resonance imaging (MRI) of the brain showed mildly elevated nonrestricted apparent diffusion coefficients in the middle cerebellar peduncles, and magnetic resonance spectroscopy (MRS) showed decreased N-acetylaspartate and creatine with increased choline. Diffusion-weighted MRI and MRS offer noninvasive methods to help evaluate in vivo physiologic changes of CNS involvement in Whipple disease.
authors.affiliation: University of Iowa College of Medicine, Iowa City, IA 52246, USA. jared-nelson@uiowa.edu
authors.forename: Jared W
authors.initials: JW
authors.lastname: Nelson
authors.forename: Matthew L
authors.initials: ML
authors.lastname: White
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Toshio
authors.initials: T
authors.lastname: Moritani
mesh_terms: D000368:Aged; D001927:Brain Diseases / Q000175:diagnosis*; D020806:Central Nervous System Bacterial Infections / Q000175:diagnosis*; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008061:Whipple Disease / Q000175:diagnosis*