Clinical consequences of IL-1 genotype on early implant failures in patients under periodontal maintenance.
BACKGROUND
Implant failure and biologic complications such as periimplantitis are not completely avoidable. Are there any genetic and microbiologic parameters that could be used to identify patients at risk for implant failure, preferably prior to treatment? This would result in improvement of the diagnostics, treatment decision, and risk assessment.


OBJECTIVE
The aims of this retrospective study were to describe (1) the absolute failure rate of Brånemark System implants (Nobel Biocare AB, Göteborg, Sweden) consecutively installed over a 10-year period in partially edentulous patients treated for periodontal disease prior to implant treatment and under regular professional maintenance, (2) the rate of interleukin-1 (IL-1) polymorphism in those patients who experienced at least one implant failure during the first year of function, and (3) the prevalence of periodontal pathogens in dental and periimplant sites with and without signs of inflammation.


METHODS
Of 766 patients, 81 encountered at least one implant failure; 22 patients were clinically examined and were tested genetically for IL-1 genotypes. The presence of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Prevotella nigrescens was analyzed.


RESULTS
The absolute implant survival rate for the whole population was 95.32%; 10.57% of the patients encountered an implant loss. Implant loss in the examined group (n = 22) was 32 of 106 (30.1%); 10 (45%) of the 22 patients were smokers, and 6 (27%) of the 22 patients were IL-1 genotype positive. Patients positive for IL-1 genotype were not more prone to implant loss; however, a significant synergistic effect with smoking was demonstrated. Between patients who were IL-1 genotype positive and those who were IL-1 genotype negative, the differences in regard to bleeding on probing or periodontal pathogens did not reach statistical significance.


CONCLUSIONS
The overall implant failure rate in a population treated and maintained for periodontal disease is similar to that of healthy subjects. A synergistic effect found between smoking and a positive IL-1 genotype resulted in a significantly higher implant loss. This indicates that further research with a larger patient group should focus on multifactorial analysis for adequate risk assessment.
Jansson
Henrik
H
Department of Periodontology, Centre for Oral Health Sciences, Malmö University, Malmö, Sweden. Henrik.Jansson@od.mah.se
Hamberg
Kristina
K
De Bruyn
Hugo
H
Bratthall
Gunilla
G
D000328:Adult; D000368:Aged; D016976:Aggregatibacter actinomycetemcomitans / Q000302:isolation & purification; D015921:Dental Implants; D003773:Dental Plaque / Q000382:microbiology; D019232:Dental Restoration Failure; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D005884:Gingival Hemorrhage / Q000276:immunology / Q000382:microbiology; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D007576:Jaw, Edentulous, Partially / Q000534:rehabilitation / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010510:Periodontal Diseases / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D010512:Periodontal Index; D011110:Polymorphism, Genetic / Q000235:genetics; D016966:Porphyromonas gingivalis / Q000302:isolation & purification; D045242:Prevotella nigrescens / Q000302:isolation & purification; D012189:Retrospective Studies; D018570:Risk Assessment; D012907:Smoking; D016019:Survival Analysis
D015921:Dental Implants; D007375:Interleukin-1