title: The role of suppressors of cytokine signalling in thymopoiesis and T cell activation.
abstract: Cytokines play an essential role in mediating interactions between cells of the immune system. Suppressors of cytokine signalling proteins act to negatively regulate these cytokine signals, thereby exerting control over the expression of cytokine responsive genes. Various lines of experimental evidence suggest that two closely related members of the this family, suppressor of cytokine signalling 1 and 3, are important in the processes of T cell development, activation and homeostasis. This review outlines the principles underlying these processes and relates these to the potentially important roles played by suppressor of cytokine signalling 1 and 3.
authors.affiliation: St. Vincent's Institute, Signal Transduction Laboratory, Fitzroy, Vic., Australia.
authors.forename: Joel
authors.initials: J
authors.lastname: Fletcher
authors.forename: Robyn
authors.initials: R
authors.lastname: Starr
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D008213:Lymphocyte Activation; D012097:Repressor Proteins / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism*; D014157:Transcription Factors / Q000502:physiology*
chemical_list: D016207:Cytokines; D012097:Repressor Proteins; D014157:Transcription Factors