Methemoglobinemia induced by topical vaginal sulfanilamide cream in a patient with cervical cancer: a case report.
BACKGROUND
Methemoglobinemia is a rare disorder most commonly associated with the ingestion or topical application of an offending exogenous agent. The clinical consequences of acute methemoglobinemia can be devastating and include lethargy, headache, and dyspnea and, as methemoglobin concentrations rise, respiratory depression, confusion, seizures, and even death.


METHODS
Here we present a case of acute methemoglobinemia induced by exposure to topical vaginal sulfanilamide cream in a 36-year-old woman with a FIGO stage IIIB squamous cell cervical carcinoma.


CONCLUSIONS
Although methemoglobinemia associated with topical anesthetics has been well documented, to our knowledge this is the first reported case of methemoglobinemia induced by exposure to topical sulfanilamide cream. Although patients undergoing intracavitary radiation treatment for cervical cancer are at risk for cyanosis due to the development of deep vein thromboses and pulmonary embolism, methemoglobinemia should be suspected in the setting of acute cyanosis with a normal arterial oxygen pressure.
Bristol
Ian
I
Department of Radiation Oncology, Unit 97, U.T. M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Brown
Jubilee
J
Slomovitz
Brian M
BM
Shannon
Vickie R
VR
Eifel
Patricia J
PJ
D000287:Administration, Topical; D000328:Adult; D001918:Brachytherapy / Q000379:methods; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000532:radiotherapy; D005260:Female; D006801:Humans; D008708:Methemoglobinemia / Q000139:chemically induced*; D000077145:Sulfanilamide; D013424:Sulfanilamides / Q000008:administration & dosage / Q000009:adverse effects*; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000532:radiotherapy
D013424:Sulfanilamides; D000077145:Sulfanilamide