title: Peroxidases: a role in the metabolism and side effects of drugs.
abstract: Current safety screening of drug candidates or new chemical entities for reactive metabolite formation focuses on the role of cytochrome P450. However, peroxidases also have a major role in drug metabolism, and peroxidase-catalyzed drug oxidation could lead to reactive metabolite formation, resulting in oxidative stress and cytotoxicity. Here, the different classes of human peroxidases are summarized and the molecular mechanisms of peroxidase-catalyzed drug metabolism are discussed. In addition, evidence is presented that indicates a role of these enzymes in drug toxicity.
authors.affiliation: Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada, M5S 2S2.
authors.forename: Shahrzad
authors.initials: S
authors.lastname: Tafazoli
authors.forename: Peter J
authors.initials: PJ
authors.lastname: O'Brien
mesh_terms: D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010544:Peroxidases / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000378:metabolism*
chemical_list: D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System; D010544:Peroxidases