An alternative synthesis of Dolby-Weinreb enamine en route to cephalotaxine.
A novel alternative synthesis of the Dolby-Weinreb enamine (2) was achieved from readily available amino dione 6 by a mild transannular Clemmensen-Clemo-Prelog-Leonard reductive rearrangement, which thus constitutes a formal total synthesis of cephalotaxine.
Ma
Bao-Chun
BC
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China.
Wang
Yong-Qiang
YQ
Li
Wei-Dong Z
WD
D006248:Harringtonines / Q000138:chemical synthesis* / Q000737:chemistry; D000077863:Homoharringtonine; D015394:Molecular Structure
D006248:Harringtonines; D000077863:Homoharringtonine