[What is the danger of long-term application of beta blockers in patients with ischemic heart disease and concomitant chronic obstructive pulmonary disease?].
OBJECTIVE
To show specific features of respiratory disoders in patients with ischemic heart disease (IHD) and chronic obstructive pulmonary disease (COPD) taking atenolol for a long time.


METHODS
A long-term study of external respiration function was made in 287 patients with IHD and COPD treated with berodual and atenolol (group 1) vs 74 matched patients taking berodual only.


RESULTS
Atenolol treated patients demonstrated more pronounced respiratory disorders. Small respiratory tracts were involved earlier with appearance of expiratory peripheral collapse and early expiratory closure of the respiratory tracts. Diffuse ability of the pulmonary tissue deteriorated. Conclusion. Atenolol has a negative effect on the respiratory system, so it is necessary to control external respiratory function in the course of treatment.
Kozlova
L I
LI
Aĭsanov
Z R
ZR
Chuchalin
A G
AG
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D000368:Aged; D001262:Atenolol / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications / Q000188:drug therapy*; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000188:drug therapy*; D012123:Pulmonary Ventilation / Q000187:drug effects; D012120:Respiration Disorders / Q000188:drug therapy
D000319:Adrenergic beta-Antagonists; D001262:Atenolol