TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early breast cancer.
Recent studies suggest that normal tissue radiosensitivity is influenced by single nucleotide polymorphisms (SNPs) in certain genes. In order to seek a confirmation of these findings, this study investigated SNPs in genes TGFB1 (position -509, codon 10 and codon 25), SOD2 (codon 16), XRCC1 (codon 399), XRCC3 (codon 241), APEX (codon 148) and ATM (codon 1853) in 26 breast cancer patients with marked changes in breast appearance after radiotherapy and 26 matched controls. Statistically significant associations were found between the TGFB1 codon 10 Pro allele (P=0.005) as well as the TGFB1 position -509 T allele (P=0.018) and increased risk of altered breast appearance. No significant associations were found for the remaining SNPs.
Andreassen
Christian Nicolaj
CN
Department of Experimental Clinical Oncology, Aarhus University Hospital, DK 8000 Aarhus, Denmark. nicolaj@oncology.dk
Alsner
Jan
J
Overgaard
Jens
J
Herskind
Carsten
C
Haviland
Jo
J
Owen
Roger
R
Homewood
Janis
J
Bliss
Judith
J
Yarnold
John
J
D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy*; D003062:Codon; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide; D011237:Predictive Value of Tests; D011379:Prognosis; D011832:Radiation Injuries / Q000209:etiology* / Q000235:genetics*; D011836:Radiation Tolerance / Q000235:genetics; D012307:Risk Factors; D013997:Time Factors; D016212:Transforming Growth Factor beta / Q000235:genetics*; D053773:Transforming Growth Factor beta1
D003062:Codon; C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1