title: [Heterogeneous distribution of the prevalence of anti-Trypanosoma cruzi antibodies among blood donors in the State of Puebla, Mexico].
abstract: OBJECTIVE
  To determine the seroprevalence and associated factors, of antibodies against Trypanosoma cruzi (T. cruzi Ab) among blood donors living in rural and suburban areas and risk regions.
  
  
  METHODS
  A cross-sectional study was conducted from January to December 2003, in 2489 blood donors of seven regions of Puebla, who were evaluated for mandatory viral and T. cruzi serological tests using validated procedures.
  
  
  RESULTS
  The seroprevalence for T. cruzi Ab was 1.24% (31/2489), similar to hepatitis C (HVC) (1.5%) and higher than human immunodeficiency virus (HIV) (0.4%) and hepatitis B (HVB) (0.3%). The highest seroprevalences were observed in the regions of Tehuacan-Sierra Negra and Mixteca, up to 2.6%, while in Sierra nororiental and Angelopolis no positive blood donors were identified. A positive association was observed between seropositivity and being older than forty years and being born and raised in Tehuacan-Sierra Negra and Mixteca.
  
  
  CONCLUSIONS
  T. cruzi seroprevalence distribution is heterogeneous, from 0% to 2.6%, with higher seroprevalences in the regions of Tehuacan-Sierra Negra and Mixteca.
authors.affiliation: Laboratorio de Inmunoparasitología, Instituto Nacional de Cardiologia Dr. Ignacio Chávez, México, DF, México.
authors.forename: Victor M
authors.initials: VM
authors.lastname: Monteón
authors.forename: Pedro A
authors.initials: PA
authors.lastname: Reyes-López
authors.forename: Adalid
authors.initials: A
authors.lastname: Sosa-Palacio
authors.forename: Gloria
authors.initials: G
authors.lastname: León-Tello
authors.forename: Jaime
authors.initials: J
authors.lastname: Martínez-Murguía
authors.forename: Francisca
authors.initials: F
authors.lastname: Sosa-Jurado
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood*; D001782:Blood Donors; D014355:Chagas Disease / Q000097:blood* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D014349:Trypanosoma cruzi / Q000276:immunology*
chemical_list: D000913:Antibodies, Protozoan