title: Synthesis and cytogenetic studies of structure--biological activity relationship of esters of Hecogenin and aza-homo-Hecogenin with N,N-bis(2-chloroethyl)aminocinnamic acid isomers.
abstract: The esters of Hecogenin and aza-homo-Hecogenin with N,N-bis(2-chloroethyl)aminocinnamic acid isomers have been prepared and their cytogenetic studies of structure-biological activity relationship were evaluated. The cytogenetic effects (sister chromatid exchanges (SCEs) induction and proliferation rate indices (PRIs) depression) by o-, m- and p-[N,N-bis(2-chloroethyl)amino] cinnamic acid were also investigated. Among the above compounds tested, those of the m-[N,N-bis(2-chloroethyl)amino] cinnamic acid and of the o-[N,N-bis(2-chloroethyl)amino] cinnamic acid ester of aza-homo-Hecogenin were more active in comparison to the others.
authors.affiliation: Laboratory of Pharmaceutical Chemistry, Department of Pharmacy, University of Patras, Greece.
authors.forename: Charalabos
authors.initials: C
authors.lastname: Camoutsis
authors.forename: Dionysios
authors.initials: D
authors.lastname: Mourelatos
authors.forename: George
authors.initials: G
authors.lastname: Pairas
authors.forename: Eleftheria
authors.initials: E
authors.lastname: Mioglou
authors.forename: Chariclia
authors.initials: C
authors.lastname: Gasparinatou
authors.forename: Zafiroula
authors.initials: Z
authors.lastname: Iakovidou
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000494:pharmacology; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D002934:Cinnamates / Q000737:chemistry*; D004951:Esterification; D006801:Humans; D007536:Isomerism; D008214:Lymphocytes / Q000187:drug effects; D015394:Molecular Structure; D009152:Mutagenicity Tests; D009588:Nitrogen Mustard Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D012502:Sapogenins / Q000737:chemistry* / Q000494:pharmacology; D012854:Sister Chromatid Exchange / Q000187:drug effects / Q000235:genetics; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001372:Aza Compounds; D002934:Cinnamates; D009588:Nitrogen Mustard Compounds; D012502:Sapogenins; C029010:cinnamic acid; C007908:hecogenin