title: 3-Ethyl-2,7-dimethyl octane, a testosterone dependent unique urinary sex pheromone in male mouse (Mus musculus).
abstract: A previous investigation revealed that urine from normal male mice contained five unique volatile constituents; namely: 3-cyclohexene-1-methanol (I); 3-amino triazole (II); 4-ethyl phenol (III); 3-ethyl-2,7-dimethyl octane (IV); 1-iodoundecane (V). The present study was designed to find out whether the production of these male specific urinary compounds was androgen-dependent. Urine of castrated and castrated plus testosterone-treated male mice was analyzed using gas chromatography linked mass spectrometry (GC-MS). Even though castrated male urine contained 10 detectable compounds, the five male specific compounds present in intact males were absent in castrated male mice urine. Only 3-ethyl-2,7-dimethyl octane (IV) reappeared following testosterone treatment into castrated males. Our earlier bioassay revealed that this compound was involved in attracting females. The present study concluded that this compound was a male specific volatile cue that acted as a releaser pheromone and its production was under the control of androgen.
authors.affiliation: Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli 620 024, Tamil Nadu, India.
authors.forename: S
authors.initials: S
authors.lastname: Achiraman
authors.forename: G
authors.initials: G
authors.lastname: Archunan
mesh_terms: D000818:Animals; D008401:Gas Chromatography-Mass Spectrometry; D008297:Male; D051379:Mice; D009795:Octanes / Q000652:urine*; D009919:Orchiectomy; D012724:Sex Attractants / Q000652:urine*; D013739:Testosterone / Q000008:administration & dosage / Q000502:physiology*; D014835:Volatilization
chemical_list: C502149:3-ethyl-2,7-dimethyloctane; D009795:Octanes; D012724:Sex Attractants; D013739:Testosterone