Lymphocyte subsets, TNF alpha and interleukin-4 levels in treated and untreated subacute sclerosing panencephalitis patients.
Immunologic studies in relation to clinical status might help to understand the pathogenesis of subacute sclerosing panencephalitis (SSPE) and the effect of treatment. We measured lymphocyte subsets and intracellular TNFalpha and interleukin-4 levels in peripheral blood in SSPE patients. Patients had elevated percentages of CD8+ cells compared to age-matched control children. Rapidly progressive course was associated with increased CD4+ cells. Treatment with interferons and inosiplex altered the percentage of CD3+, CD4+ and CD19+ cells. TNFalpha and interleukin-4 levels had no correlation with course or treatment. The proportions of lymphocyte subsets appear to have a role in the evolution or manifestations of SSPE, if not in the pathogenesis.
Anlar
Banu
B
Hacettepe University Faculty of Medicine, Department of Pediatric Neurology, Ankara, 06100, Turkey. banlar@hacettepe.edu.tr
Guven
Alev
A
Köse
Gulsen
G
Okur
Hamza
H
Kose
Ozgü
O
Aydin
Omer F
OF
Kabakus
Nimet
N
Altunbasak
Sakir
S
Herguner
Ozlem
O
Sonmez
Mujgan
M
Serdaroglu
Ayse
A
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007542:Inosine Pranobex / Q000627:therapeutic use; D007372:Interferons / Q000627:therapeutic use; D015847:Interleukin-4 / Q000097:blood*; D016131:Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism*; D008297:Male; D013344:Subacute Sclerosing Panencephalitis / Q000188:drug therapy* / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D014409:Tumor Necrosis Factor-alpha; D015847:Interleukin-4; D007372:Interferons; D007542:Inosine Pranobex