Effects of occupational trichloroethylene exposure on cytokine levels in workers.
OBJECTIVE
We sought to investigate trichloroethylene-induced alterations of the immune system in humans.


METHODS
The levels of interleukin-2, interleukin-4, and interferon-gamma in sera obtained from workers exposed to trichloroethylene were determined and compared with those of internal and external control subjects.


RESULTS
In workers with a mean urinary trichloroacetic acid concentration of 13.3 +/- 5.9 mg/g creatinine, exposed to a mean environmental trichloroethylene level of 35 +/- 14 mg/m, we observed a significant increase in sera interleukin-2 and interferon-gamma levels and a reduction in interleukin-4 concentrations compared with those of workers from the internal and external control groups.


CONCLUSIONS
This study provides the first report on quantitative immune changes induced by occupational exposure to low levels of trichloroethylene and strongly suggests that exposure to this substance alters immunohomeostasis in humans with possible effects on health.
Iavicoli
Ivo
I
Institute of Occupational Medicine, Catholic University of Sacred Heart, Rome, Italy. iavicoli.ivo@rm.unicatt.it
Marinaccio
Alessandro
A
Carelli
Giovanni
G
D000328:Adult; D000704:Analysis of Variance; D016207:Cytokines / Q000378:metabolism*; D004784:Environmental Monitoring / Q000706:statistics & numerical data*; D006801:Humans; D007154:Immune System Diseases / Q000139:chemically induced* / Q000378:metabolism*; D007371:Interferon-gamma / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000032:analysis*; D014238:Trichloroacetic Acid / Q000652:urine; D014241:Trichloroethylene / Q000032:analysis / Q000633:toxicity*
D016207:Cytokines; D007376:Interleukin-2; D015847:Interleukin-4; D014241:Trichloroethylene; D014238:Trichloroacetic Acid; D007371:Interferon-gamma