Anti-sulfatide antibodies in HIV-infected individuals with sensory neuropathy.
We used ELISA to estimate the prevalence of anti-sulfatide antibodies in HIV-infected individuals with distal sensory neuropathy (DSP) and compared the results with the prevalence in HIV-infected individuals without DSP and in individuals with neuropathy who are not infected with HIV. We found that 36% of HIV+/DSP+ individuals had immunoglobulin (Ig) G anti-sulfatide antibody titers greater than 1,500, whereas IgG anti-sulfatide antibodies were rarely found in HIV+/DSP- or HIV-/DSP+ patients.
Lopate
G
G
Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA. lopateg@neuro.wustl.edu
Pestronk
A
A
Evans
S
S
Li
L
L
Clifford
D
D
D001323:Autoantibodies / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D015658:HIV Infections / Q000097:blood / Q000150:complications / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D009437:Neuralgia / Q000209:etiology; D010292:Paresthesia / Q000209:etiology; D010523:Peripheral Nervous System Diseases / Q000097:blood / Q000150:complications / Q000276:immunology*; D011237:Predictive Value of Tests; D013433:Sulfoglycosphingolipids / Q000276:immunology*
D001323:Autoantibodies; D007074:Immunoglobulin G; D013433:Sulfoglycosphingolipids