title: Influence of the drug compatibility with polymer solution on the release kinetics of electrospun fiber formulation.
abstract: The electrospun fiber mat for drug delivery is a novel formulation with promising clinical applications in the future. The influence of the solubility and compatibility of drugs in the drug/polymer/solvent system on the encapsulation of the drug inside the poly(L-lactide) (PLLA) electrospun fibers and the release behavior of this formulation were examined by using paclitaxel, doxorubicin hydrochloride and doxorubicin base as model drugs. The burst release of the drugs can be avoided by using compatible drugs with polymers, and the drug release can follow nearly zero-order kinetics due to the degradation of the PLLA fibers in the presence of proteinase K.
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zeng
authors.forename: Lixin
authors.initials: L
authors.lastname: Yang
authors.forename: Qizhi
authors.initials: Q
authors.lastname: Liang
authors.forename: Xuefei
authors.initials: X
authors.lastname: Zhang
authors.forename: Huili
authors.initials: H
authors.lastname: Guan
authors.forename: Xiuling
authors.initials: X
authors.lastname: Xu
authors.forename: Xuesi
authors.initials: X
authors.lastname: Chen
authors.forename: Xiabin
authors.initials: X
authors.lastname: Jing
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry; D016503:Drug Delivery Systems; D004344:Drug Incompatibility; D005079:Excipients; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D017239:Paclitaxel / Q000008:administration & dosage / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D012996:Solutions; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet
chemical_list: D005079:Excipients; D004364:Pharmaceutical Preparations; D011091:Polyesters; D011108:Polymers; D012996:Solutions; D012997:Solvents; C033616:poly(lactide); D004317:Doxorubicin; D017239:Paclitaxel