title: Estimation of temporary change of activation areas by moving an analysis time window in fMRI measurement.
abstract: In this paper, we propose a method to acquire temporal changes of activations by moving an analysis time window. An advantage of this method is that it can acquire rough changes of activated areas even with the data having low time resolution. We ascertained that activations from our method do not contradict previous reports on the oddball paradigm, thus showing its effectiveness. Eight normal subjects participated in the study, which consisted of a random series of 30 target and 70 nontarget stimuli. We investigated the activated area in three kinds of analysis time sections, from stimulus onset to 5 s after the stimulus (time section A), from 2 to 7 s after (B) and from 4 to 9 s after (C). In time section A, representative activated areas were regions including the left and supplementary motor areas (SMA), and cerebellum. In B, regions including the left motor area and SMA, right parahippocampal gyrus (Broadmann Area (BA) 30), right limbic lobe and cerebellum were activated. In C, bilaterally postcentral gyrus (BA 3,40), right anterior cingulate (ACC, BA 32), left middle frontal gyrus (BA 9) and right parahippocampal gyrus were activated. Most activations were consistent with previous studies.
authors.affiliation: Department of Bio-System Engineering, Faculty of Engineering, Yamagata University, Yonezawa, Yamagata 992-8510, Japan. fukami@yz.yamagata-u.ac.jp
authors.forename: Tadanori
authors.initials: T
authors.lastname: Fukami
authors.forename: Takamasa
authors.initials: T
authors.lastname: Shimada
authors.forename: Takao
authors.initials: T
authors.lastname: Akatsuka
authors.forename: Fumito
authors.initials: F
authors.lastname: Ishikawa
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Saito
mesh_terms: D000328:Adult; D000465:Algorithms; D001921:Brain / Q000098:blood supply / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D005071:Evoked Potentials / Q000502:physiology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity