title: No effect of a type I collagen gel coating in uncemented implant fixation.
abstract: Uncemented joint replacement with a variety of substrate materials, structures, and coatings are commonplace in arthroplasty. Even with specialized surgical preparation of bone, intimate contact between the implant and host bone may not always be achieved. This study evaluated the in vivo effect of fibrillar atelopeptide and PEG crosslinked collagens coatings placed directly into porous sintered bead structures on bone ingrowth using a skeletally mature bicortical, bilateral ovine tibia model. Bone ingrowth into the implants increased with time, although differences were not significant. At 4 weeks woven bone was present within the pores that remodeled with time. Significantly lower levels of ingrowth were observed in the intramedullary region of the implants when compared with the cortical region. Implant metal type did not affect ingrowth in both regions analyzed. Both fibrillar and crosslinked forms of dermal type I collagen did not significantly alter bone ingrowth.
authors.affiliation: Orthopaedic Research Laboratories, University of New South Wales, Prince of Wales Hospital, Randwick, Sydney, Australia.
authors.forename: M
authors.initials: M
authors.lastname: Svehla
authors.forename: P
authors.initials: P
authors.lastname: Morberg
authors.forename: W
authors.initials: W
authors.lastname: Bruce
authors.forename: W R
authors.initials: WR
authors.lastname: Walsh
mesh_terms: D000497:Alloys; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001843:Bone Cements / Q000737:chemistry; D018786:Bone Substitutes / Q000737:chemistry*; D001842:Bone and Bones / Q000378:metabolism / Q000473:pathology; D003094:Collagen / Q000737:chemistry*; D024042:Collagen Type I / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000494:pharmacology; D005782:Gels / Q000737:chemistry*; D008297:Male; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration; D011092:Polyethylene Glycols / Q000737:chemistry*; D019736:Prostheses and Implants; D011474:Prosthesis Design; D012756:Sheep; D012867:Skin / Q000378:metabolism; D013314:Stress, Mechanical; D013718:Tensile Strength; D013977:Tibia / Q000473:pathology; D013997:Time Factors; D014025:Titanium / Q000737:chemistry
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D001843:Bone Cements; D018786:Bone Substitutes; D024042:Collagen Type I; D003432:Cross-Linking Reagents; D005782:Gels; C059821:atelocollagen; D011092:Polyethylene Glycols; D003094:Collagen; D014025:Titanium