title: Clobetasol propionate 0.05% lotion in the treatment of moderate to severe atopic dermatitis: a randomized evaluation versus clobetasol propionate emollient cream.
abstract: Atopic dermatitis (AD) is a chronic inflammatory and pruritic skin disorder marked by alternating periods of relapse and remission. This multicenter, randomized, active- and vehicle-controlled, investigator-blinded study compared the efficacy and safety of clobetasol propionate lotion to clobetasol propionate cream formulation and lotion vehicle in the treatment of moderate to severe AD. A total of 229 subjects applied treatment twice-daily for 2 weeks. Clobetasol propionate lotion was significantly more effective than its lotion vehicle at 2 weeks and comparable to the cream formulation. Clinical success after a 2-week, treatment-free follow-up period was greater in the clobetasol propionate lotion group than in the cream group. Clobetasol propionate lotion is effective, safe, well tolerated and offers a better remission profile in the treatment of moderate to severe AD as compared to clobetasol propionate emollient cream.
authors.affiliation: Dermatology Clinical Research Institute, Cincinnati, OH, USA.
authors.forename: Debra
authors.initials: D
authors.lastname: Breneman
authors.forename: Alan B
authors.initials: AB
authors.lastname: Fleischer
authors.forename: David
authors.initials: D
authors.lastname: Kaplan
authors.forename: Mark
authors.initials: M
authors.lastname: Lebwohl
authors.forename: Bruce
authors.initials: B
authors.lastname: Miller
authors.forename: David
authors.initials: D
authors.lastname: Pariser
authors.forename: Toivo
authors.initials: T
authors.lastname: Rist
authors.forename: L
authors.initials: L
authors.lastname: Swinyer
authors.forename: Yin
authors.initials: Y
authors.lastname: Liu
authors.forename: Valerie
authors.initials: V
authors.lastname: Foley
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002626:Chemistry, Pharmaceutical; D002648:Child; D002990:Clobetasol / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000473:pathology; D004643:Emollients / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016037:Single-Blind Method
chemical_list: D004643:Emollients; D002990:Clobetasol