Biological activities of isatin and its derivatives.
Isatin is an endogenous compound identified in humans that possesses a wide range of biological activities. Isatin has anxiogenic, sedative, anticonvulsant activities and acts as a potent antagonist on atrial natriuretic peptide receptors in vitro. A series of p-substituted isatin semicarbazones have shown anticonvulsant activity in MES, scPTZ and scSTY tests. Various isatin-N-Mannich bases of isatin-3-thiosemicarbazones have shown antiviral and tuberculostatic activity. Methisazone is an effective compound against variola and vaccinia viruses. The N-dimethyl and morpholino derivative of 5-methyl isatin and trimethoprim exhibited an EC50 of more than 4.3 and 17.7 mg mL(-1), respectively. Isatin (3-o-nitrophenyl) hydrazone has shown activity against Walker carcinoma-256. Various substituted indolinones showed antitubercular activity against M. tuberculosis H37Rv with MIC ranging from 10-20 microg mL(-1). Isatin derivatives of Mannich bases had fibrinolytic, muscle relaxant, antiallergic, immunosuppressant, and antithrombotic activity. Isatin showed cardioinhibitory effect on frog heart, and hypotensive, respiratory depression and antidiuretic effects.
Pandeya
Surendra Nath
SN
Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi-221 005, India. snpandeya@rediffmail.com
Smitha
Sivakumar
S
Jyoti
Mayank
M
Sridhar
Seshaiah Krishnan
SK
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000927:Anticonvulsants / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology; D002492:Central Nervous System Depressants / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007510:Isatin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008352:Mannich Bases / Q000737:chemistry; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D012545:Schiff Bases / Q000737:chemistry; D012664:Semicarbazones / Q000737:chemistry
D000900:Anti-Bacterial Agents; D000927:Anticonvulsants; D000935:Antifungal Agents; D000998:Antiviral Agents; D002492:Central Nervous System Depressants; D008352:Mannich Bases; D008996:Monoamine Oxidase Inhibitors; D012545:Schiff Bases; D012664:Semicarbazones; D007510:Isatin