title: Ventricular arrhythmia following short-acting nifedipine administration.
abstract: Short-acting nifedipine is still advocated for use in children with severe hypertension, but is no longer recommended for use in adults because of adverse effects from rapid blood pressure reduction. A 19 year-old adolescent with symptomatic, severe hypertension (blood pressure 180/120) received 10 mg of short-acting nifedipine sublingually for blood pressure reduction. Within minutes after the dose, the patient complained of palpitations. Tachycardia (heart rate 100 beats per minute) and bigeminy were noted on the cardiac monitor. The bigeminy resolved but premature ventricular contractions were noted for the duration of her hospital stay. We hypothesize that reflex sympathetic activation following an abrupt drop in blood pressure may cause arrhythmias because of elevated catecholamine levels. Given this, it may be more appropriate to treat severe hypertension in children with intravenous antihypertensive agents that can be titrated to produce controlled reductions in blood pressure.
authors.affiliation: Division of Pediatric Nephrology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: M Patricia
authors.initials: MP
authors.lastname: Castaneda
authors.forename: Christine A
authors.initials: CA
authors.lastname: Walsh
authors.forename: Robert P
authors.initials: RP
authors.lastname: Woroniecki
authors.forename: Marcela
authors.initials: M
authors.lastname: Del Rio
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Flynn
mesh_terms: D000286:Administration, Sublingual; D000328:Adult; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D009543:Nifedipine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D017180:Tachycardia, Ventricular / Q000139:chemically induced*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D018879:Ventricular Premature Complexes / Q000139:chemically induced*
chemical_list: D014665:Vasodilator Agents; D009543:Nifedipine