title: Urinary and serum concentrations of diclofenac after topical application to horses.
abstract: The liposomal cream formulation of diclofenac, an NSAID, is an effective, safe, and convenient way to treat localized areas of inflammation in horses. The results of this study reveal urinary and serum concentrations of diclofenac following topical administration of 1% liposomal diclofenac cream for 10 days at the labeled dose and at 2X and 4X the labeled dose. These results demonstrate the slow absorption and elimination of 1% liposomal diclofenac cream and may be useful when estimating the withdrawal time needed before a competition in order to prevent an inadvertent positive drug test.
authors.affiliation: Department of Physiological Sciences, Racing Laboratory, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Danielle
authors.initials: D
authors.lastname: Anderson
authors.forename: Cynthia
authors.initials: C
authors.lastname: Kollias-Baker
authors.forename: Pat
authors.initials: P
authors.lastname: Colahan
authors.forename: Robert O
authors.initials: RO
authors.lastname: Keene
authors.forename: Randy C
authors.initials: RC
authors.lastname: Lynn
authors.forename: Douglas I
authors.initials: DI
authors.lastname: Hepler
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology* / Q000652:urine; D019540:Area Under Curve; D004008:Diclofenac / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D004334:Drug Administration Schedule; D006736:Horses / Q000378:metabolism*; D008297:Male
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac