Cyclolignans from Scyphocephalium ochocoa via high-throughput natural product chemistry methods.
Two 2,7'-cyclolignans, ocholignans A and B, were obtained as mass-limited samples from Scyphocephalium ochocoa via high-throughput natural products chemistry methods. The rapid structure elucidation of each compound was primarily facilitated by NMR data acquisition using a capillary-scale NMR probe, CapNMR probe. Ocholignan A was found to possess significant in vitro antibacterial activity against Gram-positive bacteria methicillin-resistant Staphylococcus aureus ATCC 33591 and S. aureus 78-13607A with a MIC of 16 microg/mL, respectively.
Hu
Jin-Feng
JF
Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc., 11199 Sorrento Valley Road, Suite H, San Diego, CA 92121, USA. jhu@sequoiasciences.com
Garo
Eliane
E
Yoo
Hye-Dong
HD
Cremin
Peadar A
PA
Goering
Matt G
MG
O'Neil-Johnson
Mark
M
Eldridge
Gary R
GR
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D026324:Myristicaceae / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D017705:Lignans; C503017:ocholignan A; C503016:ocholignan B