Vascular involvement in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes.
A 26-year-old man with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) was admitted to our hospital for further cardiovascular examination. A muscle biopsy demonstrated strongly succinate dehydrogenase-reactive blood vessels. Pulse wave contour analysis revealed that both capacitive and oscillatory compliance were markedly reduced in this patient compared with 45 normal age-matched control subjects. Hepatocyte growth factor was remarkably elevated in this patient over that of 10 normal control subjects. These findings suggest that a MELAS patient has not only pathologic but also functional vascular involvement. If so, patients with MELAS need systemic vascular assessment.
Takahashi
Nobuyuki
N
Division of Cardiovascular Medicine, Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo City, Shimane, Japan.
Shimada
Toshio
T
Murakami
Yo
Y
Katoh
Harumi
H
Oyake
Nobuyuki
N
Ishibashi
Yutaka
Y
Nishino
Ichizo
I
Nonaka
Ikuya
I
Goto
Yu-Ichi
Y
D000328:Adult; D001808:Blood Vessels / Q000201:enzymology; D017228:Hepatocyte Growth Factor / Q000096:biosynthesis / Q000097:blood; D006801:Humans; D017241:MELAS Syndrome / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D018482:Muscle, Skeletal / Q000098:blood supply / Q000473:pathology; D013385:Succinate Dehydrogenase / Q000378:metabolism; D014652:Vascular Diseases / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*
D017228:Hepatocyte Growth Factor; D013385:Succinate Dehydrogenase