Feasibility of in vivo, multicontrast-weighted MR imaging of carotid atherosclerosis for multicenter studies.
OBJECTIVE
To test the image quality (ImQ) and interscan coverage of MRI for measuring carotid atherosclerosis across multiple centers.


METHODS
Thirty-nine subjects from five clinical sites (site 1: n=11; site 2: n=16; site 3: n=2; site 4: n=3; site 5: n=7) were imaged on GE 1.5T scanners using a standardized carotid imaging protocol with five weightings (T1, proton density (PD), T2, time-of-flight (TOF), and contrast-enhanced (CE) T1). MR technologists from the five sites received comprehensive protocol training. A maximum coverage of 24 mm (12 slices) was designed for each of four scans (baseline and at four, eight, and 13 weeks). The adequacy of coverage was calculated as the percentage of arteries with at least six slices matched across all four scans. ImQ was evaluated using an established five-point scale for each image. ImQ>or= 3 was considered acceptable for image analysis.


RESULTS
Across five sites, the mean ImQ was 3.4-4.2 for T1W, 3.6-4.4 for CE-T1W, 3.4-4.2 for PDW, 3.3-4.2 for T2W, and 3.4-4.0 for TOF. The mean ImQ per site was 3.5-4.2. All sites generated at least six-slice coverage (mean=8.0-9.1) for all index carotid arteries.


CONCLUSIONS
The ImQ and coverage values were comparable among clinical sites using a standardized carotid imaging protocol. With comprehensive protocol training, carotid MRI is technically feasible for use in multicenter studies.
Chu
Baocheng
B
Department of Radiology, University of Washington, Seattle, Washington 98195, USA. chubc@u.washington.edu
Zhao
Xue-Qiao
XQ
Saam
Tobias
T
Yarnykh
Vasily L
VL
Kerwin
William S
WS
Flemming
Kelly D
KD
Huston
John
J
Insull
William
W
Morrisett
Joel D
JD
Rand
Scott D
SD
DeMarco
Kevin J
KJ
Polissar
Nayak L
NL
Balu
Niranjan
N
Cai
Jianming
J
Kampschulte
Annette
A
Hatsukami
Thomas S
TS
Yuan
Chun
C
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D002340:Carotid Artery Diseases / Q000175:diagnosis*; D003287:Contrast Media; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results
D003287:Contrast Media