Use of bioelectrical impedance analysis to determine body composition changes in HIV-associated wasting.
AIDS wasting syndrome results in loss of lean body mass and body cell mass. This 12-week, open-label study used bioelectrical impedance analysis to measure body composition changes in 24 patients with AIDS wasting syndrome receiving recombinant human growth hormone (r-hGH). The primary endpoint was percentage monthly change in body weight before/after r-hGH. Secondary endpoints included change from baseline in body composition (bioelectrical impedance analysis), isometric strength and CD4+ count. Twenty patients completed the study: r-hGH resulted in mean weight gains (+2.7%, P = 0.146), and significant increases in mean body cell mass (+8.0%, P = 0.0211), lean body mass (+4.8%, P = 0.0373) and water (+5.5%, P < 0.023). Body fat decreased throughout, but not significantly. r-hGH was generally well tolerated; the most frequent adverse events were fever (7.3%) and diarrhoea (6.3%). Thus, bioelectrical impedance analysis can detect improved body cell mass independent of changes in body weight resulting from r-hGH treatment in patients with AIDS wasting syndrome.
Klauke
Stephan
S
HIV-Schwerpunktpraxis, Frankfurt, Germany. stklauke@aol.com
Fischer
Harald
H
Rieger
Armin
A
Frühauf
Lukas
L
Staszewski
Schlomo
S
Althoff
Peter-Henning
PH
Helm
Eilke Brigitte
EB
D000328:Adult; D000368:Aged; D001823:Body Composition; D017097:Electric Impedance; D019247:HIV Wasting Syndrome / Q000175:diagnosis* / Q000188:drug therapy*; D018737:Hand Strength; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged
D019382:Human Growth Hormone