title: Periprosthetic bone remodeling around a prosthesis for distal femoral tumors: longitudinal follow-up.
abstract: Serial measurements using dual-energy x-ray absorptiometry (DEXA) were undertaken to evaluate progressive periprosthetic bone loss in patients treated for primary bone tumors of the distal femur using an uncemented tumor prosthesis. Twelve patients underwent sequential DEXA analysis on average 26.5 and 90.9 months postsurgery. Changes in bone mineral density were measured in regions of interest (ROIs) around the prosthesis stem. The test-retest reliability coefficient (r) ranged from 0.92 to 0.99 for all ROI. In the most distal ROI (ROI1), 10 of 11 patients with 2 measurements showed no change or a small increase in absolute bone mineral density. The results in other ROIs were similar. This longitudinal DEXA data suggest that progressive bone resorption is not problematic with an uncemented distal femur endoprosthesis at intermediate follow-up. Key words: DEXA, stress shielding, uncemented endoprothesis, tumor, bone loss.
authors.affiliation: Toronto Rehabilitation Institute, Toronto, Canada.
authors.forename: Aileen M
authors.initials: AM
authors.lastname: Davis
authors.forename: Mansour
authors.initials: M
authors.lastname: Damani
authors.forename: Lawrence M
authors.initials: LM
authors.lastname: White
authors.forename: Jay S
authors.initials: JS
authors.lastname: Wunder
authors.forename: Anthony M
authors.initials: AM
authors.lastname: Griffin
authors.forename: Robert S
authors.initials: RS
authors.lastname: Bell
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D019644:Arthroplasty, Replacement, Hip; D015519:Bone Density; D001859:Bone Neoplasms / Q000503:physiopathology* / Q000601:surgery; D016723:Bone Remodeling / Q000502:physiology*; D001862:Bone Resorption / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged