title: Clinical relevance of systemic and local IGF-I.
abstract: The insulin-like growth factor family of ligands, receptors and binding proteins are critical for many normal physiological functions. These include normal development during fetal and post-natal development and maintenance of organ function in adult life. Circulating IGF-I is produced primarily by the liver under GH control, whereas the production of tissue IGF-I has other controls. Recent studies have demonstrated that both circulating and tissue IGF-I are important for maintaining the normal structure-function of complex organs such as bone. Circulating IGF-I is important for maintaining ambient GH levels; in its absence GH elevation is seen leading to insulin resistance. In addition, low levels of circulating IGF-I retard the progression and metastatic potential of a number of cancers.
authors.affiliation: Diabetes Branch, NIDDK, NIH MSC, Bethesda, Md., USA.
authors.forename: Shoshana
authors.initials: S
authors.lastname: Yakar
authors.forename: Patricia
authors.initials: P
authors.lastname: Pennisi
authors.forename: Yiping
authors.initials: Y
authors.lastname: Wu
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
authors.forename: Derek
authors.initials: D
authors.lastname: LeRoith
mesh_terms: D000818:Animals; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000502:physiology*; D009369:Neoplasms / Q000235:genetics / Q000503:physiopathology*
chemical_list: D007334:Insulin-Like Growth Factor I