Bridging the Gap between mesoscopic and macroscopic models: the case of multicellular tumor spheroids.
Multicellular tumor spheroids are valuable experimental tools in cancer research. By introducing an intermediate model, we have been able to successfully relate mesoscopic and macroscopic descriptions of spheroid growth. Since these descriptions stem from completely different roots (cell dynamics, and energy conservation and scaling arguments, respectively), their consistency validates both approaches and allows us to establish a direct correspondence between parameters characterizing processes occurring at different scales. Our approach may find applications as an example of bridging the gap between models at different scale levels in other contexts.
Delsanto
P P
PP
Department of Physics, Politecnico of Torino, Torino, Italy.
Griffa
M
M
Condat
C A
CA
Delsanto
S
S
Morra
L
L
D048708:Cell Growth Processes / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D003198:Computer Simulation; D008954:Models, Biological; D009369:Neoplasms / Q000473:pathology*; D018874:Spheroids, Cellular / Q000473:pathology*