title: Late auditory and event-related potentials can be useful to predict good functional outcome after coma.
abstract: OBJECTIVE
  To investigate whether late auditory and event-related potentials, and in particular N100 and mismatch negativity, together with clinical parameters, can help to predict good functional outcome in comatose patients.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Hospital.
  
  
  METHODS
  Consecutively sampled comatose patients (N=346) whose etiologies of coma were stroke (125 patients), brain injury (96 patients), anoxia (64 patients), complication of neurosurgery (54 patients), and encephalitis (7 patients).
  
  
  METHODS
  Not applicable.
  
  
  METHODS
  Glasgow Outcome Scale score at 1 year postonset. Patients in a minimally conscious state and those who awoke and died during the follow-up period were classified separately.
  
  
  RESULTS
  Univariate analysis showed that all variables studied, except brainstem auditory evoked potentials, correlated significantly with functional outcome. Mismatch negativity showed the highest positive predictive value for good outcome. A validated model was obtained with multivariate logistic analysis, including pupillary light reflex, N100, mismatch negativity, etiology, and age.
  
  
  CONCLUSIONS
  Late auditory and event-related potentials, and particularly N100 and mismatch negativity, provide strong prognostic factors for good functional outcome. Furthermore, these components may enhance the accuracy of prognosis when associated with other clinical parameters available at the early stage of coma.
authors.affiliation: Rééducation Neurologique, Pavillon Delore, Hôpital H. Gabrielle, Hospices Civils de Lyon, France. jacques.luaute@chu-lyon.fr
authors.forename: Jacques
authors.initials: J
authors.lastname: Luauté
authors.forename: Catherine
authors.initials: C
authors.lastname: Fischer
authors.forename: Patrice
authors.initials: P
authors.lastname: Adeleine
authors.forename: Dominique
authors.initials: D
authors.lastname: Morlet
authors.forename: Laurence
authors.initials: L
authors.lastname: Tell
authors.forename: Dominique
authors.initials: D
authors.lastname: Boisson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003128:Coma / Q000503:physiopathology*; D005071:Evoked Potentials / Q000502:physiology*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D020127:Recovery of Function; D012025:Reflex, Pupillary / Q000502:physiology