[A study on the expression of HSP70 and iNOS after human brain contusion].
OBJECTIVE
To study the relationship between expression of HSP70, iNOS and traumatic brain contusion (TBI) in different posttraumatic intervals.


METHODS
35 samples of brain contusion were examined using immunohistochemecal staining to evaluate the expression of HSP70 and iNOS.


RESULTS
Maximal HSP70 expression was found at 0h after brain contusion. The intensity of HSP70 staining decreased remarkably to the minimum at 24h after TBI, then increased gradually. Expression of iNOS positive cells increased significantly and reached the maximum level 48h after TBI, then the expression decreased gradually from the 2nd day to the 11th day.


CONCLUSIONS
The changes of HSP70 and iNOS immunohistochemical staining can be used as a referential data for estimating time interval after human brain contusion.
Zhang
Wei
W
School of Forensic Medicine, China Medical University, Shenyang 110001, China.
Wang
De-wen
DW
Sun
Xiao-dong
XD
D000328:Adult; D001253:Astrocytes / Q000378:metabolism; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D001930:Brain Injuries / Q000378:metabolism* / Q000473:pathology; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000096:biosynthesis*; D013194:Staining and Labeling; D013997:Time Factors
D018840:HSP70 Heat-Shock Proteins; D052247:Nitric Oxide Synthase Type II