P/Q-type calcium channel antibodies, Lambert-Eaton myasthenic syndrome and survival in small cell lung cancer.
To assess the survival impact of the presence of P/Q-type calcium channel antibodies in patients with small cell lung carcinoma (SCLC), we examined the frequency of the antibodies and Lambert-Eaton myasthenic syndrome (LEMS) in 148 consecutive patients with SCLC, and in 30 patients with paraneoplastic cerebellar degeneration and SCLC, and studied their relation with survival. In both series, only patients with LEMS had a remarkably long survival, whereas presence of the antibodies without LEMS did not result in a better prognosis.
Wirtz
Paul W
PW
Department of Neurology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands. pwwirtz@lumc.nl
Lang
Bethan
B
Graus
Francesc
F
van den Maagdenberg
Arn M J M
AM
Saiz
Albert
A
de Koning Gans
Pia A
PA
Twijnstra
Albert
A
Verschuuren
Jan J G M
JJ
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood; D015153:Blotting, Western / Q000379:methods; D020864:Calcium Channels, N-Type / Q000276:immunology*; D018288:Carcinoma, Small Cell / Q000097:blood / Q000453:epidemiology / Q000276:immunology* / Q000401:mortality*; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D047468:Immunoprecipitation / Q000379:methods; D015624:Lambert-Eaton Myasthenic Syndrome / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay / Q000379:methods; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology
D001323:Autoantibodies; D020864:Calcium Channels, N-Type