title: Ocular manifestations in congenital toxoplasmosis.
abstract: BACKGROUND
  Retinochoroiditis is the most common ocular manifestation of congenital toxoplasmosis, but other associated ophthalmological pathologies can also occur. The aim of this study was to determine the nature of the latter in treated cases of the disease and to assess their impact on visual function.
  
  
  METHODS
  Four hundred and thirty consecutive children with serologically confirmed congenital toxoplasmosis were included in this study. Data were prospectively collected using standardized ophthalmological assessment forms. The presence of retinochoroiditis and of associated pathologies was ascertained, and their impact on visual function was assessed.
  
  
  RESULTS
  After a median follow-up of 12 years [range 0.6-26 years], 130 children manifested retinochoroiditis. We detected 22 foci of retinochoroiditis at birth and 264 additional ones during the follow-up period. Of these, 48 (17%) were active when first diagnosed. Twenty-five of the 130 children (19%) had other associated ocular pathologies. Of these, 21 (16%) had a strabismus, which was due to macular lesions in 86% of the cases; 7 (5.4%) presented with unilateral microphthalmia, and 4 (3%) with cataracts. Most of these events were detected after the onset of retinochoroiditis. None of the children presented with ocular involvement in the absence of chorioretinal lesions. Macular lesions occurred more frequently in children with associated pathologies (p<0.0001), and associated pathologies were likewise more common in individuals with macular lesions (p=0.0003). Visual impairment occurred in 31/130 cases, and in all but 3 of these eyes it was due not to an associated pathology but to macular retinochoroiditis.
  
  
  CONCLUSIONS
  At the end of the follow-up period, ocular involvement existed in 30% of the treated children with congenital toxoplasmosis. Associated eye pathologies were manifested less frequently than anticipated. They may occur later in life and are an indirect marker of the severity of congenital toxoplasmosis, but they do not have a direct impact on visual acuity. The overall functional prognosis of congenital toxoplasmosis is better than would be expected on the basis of literature findings, with only 2 of the 130 children suffering bilateral visual impairment.
authors.affiliation: Department of Ophthalmology, Croix-Rousse Hospital, Claude Bernard Lyon I University, Lyon, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Kodjikian
authors.forename: Martine
authors.initials: M
authors.lastname: Wallon
authors.forename: Jacques
authors.initials: J
authors.lastname: Fleury
authors.forename: Philippe
authors.initials: P
authors.lastname: Denis
authors.forename: Christine
authors.initials: C
authors.lastname: Binquet
authors.forename: François
authors.initials: F
authors.lastname: Peyron
authors.forename: Justus G
authors.initials: JG
authors.lastname: Garweg
mesh_terms: D000293:Adolescent; D000328:Adult; D000913:Antibodies, Protozoan / Q000097:blood; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002825:Chorioretinitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D011739:Pyrimethamine / Q000627:therapeutic use; D013413:Sulfadoxine / Q000627:therapeutic use; D014125:Toxoplasmosis, Congenital / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D014126:Toxoplasmosis, Ocular / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D014786:Vision Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*
chemical_list: D000913:Antibodies, Protozoan; D000981:Antiprotozoal Agents; D004338:Drug Combinations; C001205:fanasil, pyrimethamine drug combination; D013413:Sulfadoxine; D011739:Pyrimethamine