title: The yeast Mediator complex and its regulation.
abstract: The Mediator complex acts as a bridge, conveying regulatory information from enhancers and other control elements to the basal RNA polymerase II transcription machinery. Mediator is required for the regulated transcription of nearly all RNA polymerase II-dependent genes in Saccharomyces cerevisiae, and post-translational modifications of specific Mediator subunits can affect global patterns of gene transcription.
authors.affiliation: Department of Medical Biochemistry, Umeå University, S-901 87 Umeå, Sweden. stefan.bjorklund@medchem.umu.se
authors.forename: Stefan
authors.initials: S
authors.lastname: Björklund
authors.forename: Claes M
authors.initials: CM
authors.lastname: Gustafsson
mesh_terms: D000818:Animals; D015966:Gene Expression Regulation, Fungal; D056892:Mediator Complex; D046912:Multiprotein Complexes; D011499:Protein Processing, Post-Translational; D021122:Protein Subunits / Q000235:genetics / Q000378:metabolism; D012319:RNA Polymerase II / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: C058337:GAL11 protein, S cerevisiae; D056892:Mediator Complex; D046912:Multiprotein Complexes; D021122:Protein Subunits; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators; D012319:RNA Polymerase II