[Identifying different susceptibility loci associated with early onset diabetes and cardiovascular disease in Mexican families].
Coronary artery disease and diabetes mellitus are among the primary mortality and morbidity causes in Mexico. Genetic factors play a fundamental role in the development of these entities. In the past few years due to the recognition and study of families with monogenic forms of diabetes and dislipidemias associated with development of atherosclerosis, several genes and loci have been associated with these conditions through genetic linkage studies. These studies have provided evidence of the genetic heterogeneity that exists and the type of genes involved in different ethnic groups. The study of Mexican families with early-onset diabetes and combined familial hyperlipidemia showed the participation of different genetic loci associated with these conditions in the Mexican population. These findings show the value of gene mapping strategies in the identification of the genetic component in these entities in our population.
Canizales-Quinteros
Samuel
S
Unidad de Biología Molecular y Medicina Genómica del Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán y del Instituto de Investigaciones Biomédicas de la UNAM, México.
Huertas-Vázquez
Adriana
A
Riba-Ramírez
Laura
L
Monroy-Guzmán
Adriana
A
Domínguez-López
Aarón
A
Romero-Hidalgo
Sandra
S
Aguilar-Salinas
Carlos
C
Rodríguez-Torres
Maribel
M
Ramírez-Jiménez
Salvador
S
Tusié-Luna
María Teresa
MT
D000293:Adolescent; D000328:Adult; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D002874:Chromosome Mapping; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000235:genetics*; D004198:Disease Susceptibility / Q000453:epidemiology*; D005190:Family; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology