title: Does ethanol explain the acidosis commonly seen in ethanol-intoxicated patients?
abstract: OBJECTIVE
  Emergency physicians frequently treat ethanol-intoxicated trauma patients. In patients with apparently minor injuries, the presence of metabolic acidosis is often attributed to serum ethanol. We tested whether there is justification for the bias that ethanol reliably explains the acidosis commonly seen in alcohol-intoxicated patients.
  
  
  METHODS
  Prospective, observational.
  
  
  METHODS
  Ethanol-intoxicated patients admitted to the emergency department (ED) following significant trauma mechanisms, in whom diagnostic evaluation revealed only minor injury.
  
  
  METHODS
  Major trauma (blood transfusions, drop in Hct > 10 points over 24 h, or Injury Severity Score [ISS] >5) or positive urine toxicology screen.
  
  
  BACKGROUND
  Ethanol Intoxication: (Blood Alcohol Level (BAL) > or =80 mg/dl), Acidosis: BD < or = -3.0 mMol/L; Lactic Acidosis (LAC >2.2 mMol/L). Data were reported as mean+/-SD. Data were compared by t-tests or Fishers exact test as appropriate (alpha= 0.05, 2 tails) and correlations by Pearson correlation coefficient.
  
  
  RESULTS
  192 patients were studied (84% male) with a mean age of 31.7+/-15.6 years. Acidosis was observed in 19.3% (CI 95%, 14.5% to 25.0%) of all study patients. We observed significant (p<0.001) difference in prevalence of acidosis in ethanol intoxicated (42%) compared to nonintoxicated (1%) patients. Comparing the two study groups, patients with ethanol intoxication had lower BD (-2.24+/-2.74 vs. -0.05+/-2.35, p<0.001) and higher LAC (2.69+/-1.48 vs. 2.00+/-1.78, p=0.02). However, ethanol levels did not correlate significantly with BD (p=0.50) or LAC (p=0.14).
  
  
  CONCLUSIONS
  Ethanol intoxication is associated with acidosis, which does not correlate with BD or LAC. The complexity of pathogenesis of acidosis in ethanol intoxication justifies further diagnostic evaluation of these patients in order to rule out other causes of acidosis.
authors.affiliation: Department of Emergency Medicine, Downstate Medical Center, State University of New York, Brooklyn, NY 11203, USA. zehtab@yahoo.com
authors.forename: Shahriar
authors.initials: S
authors.lastname: Zehtabchi
authors.forename: Richard
authors.initials: R
authors.lastname: Sinert
authors.forename: Bonny J
authors.initials: BJ
authors.lastname: Baron
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Paladino
authors.forename: Kabir
authors.initials: K
authors.lastname: Yadav
mesh_terms: D000140:Acidosis, Lactic / Q000097:blood* / Q000209:etiology / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000435:Alcoholic Intoxication / Q000097:blood* / Q000150:complications / Q000473:pathology; D004635:Emergency Medicine; D000431:Ethanol / Q000097:blood / Q000506:poisoning; D005260:Female; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014947:Wounds and Injuries / Q000097:blood* / Q000150:complications / Q000473:pathology
chemical_list: D000431:Ethanol