Impact of p53 aberration on the progression of Adult T-cell Leukemia/Lymphoma.
Based on statistical analysis of its age-dependent occurrence, a multi-step carcinogenesis model has been proposed for Adult T-cell Leukemia/Lymphoma (ATLL). We have previously reported that the deletion of the p16 gene is a key event in ATLL progression. In the current study, we report for the first time that the aberrations of p16 and p53 are mutually exclusive in ATLL and either of the two events is sufficient for the ATLL progression. More than half of the patients had one of the two aberrations, and both aberrations emerged as significant markers for a poor prognosis.
Tawara
Masayuki
M
Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Hogerzeil
Simon J
SJ
Yamada
Yasuaki
Y
Takasaki
Yumi
Y
Soda
Hiroshi
H
Hasegawa
Hiroo
H
Murata
Ken
K
Ikeda
Shuichi
S
Imaizumi
Yoshitaka
Y
Sugahara
Kazuyuki
K
Tsuruda
Kazuto
K
Tsukasaki
Kunihiro
K
Tomonaga
Masao
M
Hirakata
Yoichi
Y
Kamihira
Shimeru
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics*; D002869:Chromosome Aberrations; D018450:Disease Progression; D005260:Female; D019942:Genes, p16; D016158:Genes, p53; D006801:Humans; D015458:Leukemia, T-Cell / Q000235:genetics*; D016399:Lymphoma, T-Cell / Q000235:genetics*; D008297:Male; D018807:Polymorphism, Single-Stranded Conformational; D011379:Prognosis; D020133:Reverse Transcriptase Polymerase Chain Reaction
D014408:Biomarkers, Tumor