Polymorphisms in the serotonin transporter gene and their relationship to two temperamental traits measured by the formal characteristics of behavior-temperament inventory: activity and emotional reactivity.
Results obtained in earlier studies indicate that 5-HTT gene polymorphisms may have a certain impact on individual differences with respect to temperamental traits. The aim of our study was to determine whether the occurrence of various alleles of the serotonin transporter gene is related to the variability of two temperamental traits postulated in the Regulative Theory of Temperament (RTT)--activity and emotional reactivity. We have demonstrated that the 5-HTTLPR polymorphism is associated with one of the RTT temperamental traits--activity. Neither the relationship between the regulatory region polymorphism and emotional reactivity nor the association between the intron 2 VNTR polymorphism and the temperamental traits under study has been confirmed.
Dragan
Wojciech Ł
WŁ
Faculty of Psychology, University of Warsaw, Stawki 5-7, PL-00-183 Warsaw, Poland. wdragan@engram.psych.uw.edu.pl
Oniszczenko
Włodzimierz
W
D000293:Adolescent; D000328:Adult; D016009:Chi-Square Distribution; D004644:Emotions / Q000502:physiology*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007438:Introns; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins / Q000235:genetics*; D018598:Minisatellite Repeats / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010551:Personality / Q000235:genetics*; D010555:Personality Inventory / Q000706:statistics & numerical data; D011110:Polymorphism, Genetic; D012333:RNA, Messenger / Q000096:biosynthesis; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D050486:Serotonin Plasma Membrane Transport Proteins; D013694:Temperament / Q000502:physiology*
D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins