Epoxytwinol A, a novel unique angiogenesis inhibitor with C2 symmetry, produced by a fungus.
We isolated a novel unique pentaketide dimer designated as epoxytwinol A from the fermentation broth of a fungus. The structure of epoxytwinol A was determined to have a new carbon skeleton with C(2) symmetry by elucidation of spectroscopic evidence. Epoxytwinol A inhibited endothelial cell migration stimulated by vascular endothelial growth factor (ED(100)= 2.6 microM).
Kakeya
Hideaki
H
Antibiotics Laboratory, Discovery Research Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. hkakeya@riken.jp
Onose
Rie
R
Koshino
Hiroyuki
H
Osada
Hiroyuki
H
D020533:Angiogenesis Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D002465:Cell Movement / Q000187:drug effects; D002478:Cells, Cultured; D019281:Dimerization; D004305:Dose-Response Relationship, Drug; D042783:Endothelial Cells / Q000187:drug effects; D004852:Epoxy Compounds / Q000737:chemistry* / Q000494:pharmacology; D005658:Fungi / Q000737:chemistry*; D006801:Humans; D006873:Hydroquinones / Q000737:chemistry* / Q000494:pharmacology; D008968:Molecular Conformation
D020533:Angiogenesis Inhibitors; D004852:Epoxy Compounds; D006873:Hydroquinones; C496191:epoxytwinol A