[New oxaanalogues of spermine].
A new isosteric charge-deficient spermine analogue, 1,12-diamino-4,9-diaza-5-oxadodecan, and O-(7-amino-4-azaheptyl)oxime of 3-aminopropanal, a stable analogue of the Schiff base intermediate in the enzymatic oxidation of spermine, were synthesized. The possible use of these compounds for the inhibition of spermine oxidase is discussed.
Khomutov
A R
AR
Simonian
A R
AR
Vespalainen
J
J
Keinanen
T A
TA
Alhonen
L
L
Janne
J
J
D009682:Magnetic Resonance Spectroscopy; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000037:antagonists & inhibitors; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000737:chemistry; D013096:Spermine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D000097667:Polyamine Oxidase
D000587:Oxidoreductases Acting on CH-NH Group Donors; D012545:Schiff Bases; D013096:Spermine; D000097667:Polyamine Oxidase; C502958:1,12-diamino-4,9-diaza-5-oxadodecan; C502959:O-(7-amino-4-azaheptyl)oxime of 3-aminopropanal