Phytotoxins from the fungus Malbranchea aurantiaca.
Bioassay-directed fractionation of an ethyl acetate extract from cultures of the fungus Malbranchea aurantiaca led to the isolation of two phytotoxic compounds, namely, 1-hydroxy-2-oxoeremophil-1(10),7(11),8(9)-trien-12(8)-olide (1) and penicillic acid (2). The structure of 1 was established by spectroscopic and X-ray crystallographic analyses. Metabolites 1 and 2 caused significant inhibition of radicle growth of Amaranthus hypochondriacus with IC(50) values 6.57 and 3.86 microM, respectively. In addition, 1 inhibited activation of the calmodulin-dependent enzyme cAMP phosphodiesterase (IC(50)=10.2 microM).
Martínez-Luis
Sergio
S
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, D.F. 04510, México.
González
María C
MC
Ulloa
Miguel
M
Mata
Rachel
R
D001203:Ascomycota / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009183:Mycotoxins / Q000737:chemistry* / Q000494:pharmacology; D010398:Penicillic Acid / Q000737:chemistry* / Q000494:pharmacology; D010944:Plants / Q000187:drug effects*; D012717:Sesquiterpenes
C503015:1-hydroxy-2-oxoeremophil-1(10),7(11),8(9)-trien-12(8)-olide; D009183:Mycotoxins; D012717:Sesquiterpenes; D010398:Penicillic Acid