Differential role of tumor necrosis factor receptors in TNBS colitis.
BACKGROUND
Tumor necrosis factor alpha (TNFalpha) plays a central role in the pathology of T helper 1-mediated colitis such as Crohn's disease; however, the role of its 2 receptors in mediating pathology has not been fully explored.


METHODS
Trinitrobenzene sulfonic acid colitis was used to induce colitis in mice lacking each of the TNF receptors (TNFRs) and in wild-type mice. TNFR1-/- mice lost more weight, became hypothermic, and had increased mortality compared with wild-type C57Bl/6 mice. TNFR2-/- mice, however, lost less weight, had normal temperatures, and had improved survival.


RESULTS
Despite the improved clinical outcomes in TNFR2-/- mice, TNFalpha levels were increased in these mice.


CONCLUSIONS
TNFalpha signaling through TNFR1 is protective in the trinitrobenzene sulfonic acid mouse model of inflammatory bowel disease.
Ebach
Dawn R
DR
Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Washington University, St. Louis, Missouri, USA.
Newberry
Rodney
R
Stenson
William F
WF
D000818:Animals; D003092:Colitis / Q000503:physiopathology* / Q000662:veterinary; D004195:Disease Models, Animal; D007035:Hypothermia / Q000209:etiology; D051379:Mice; D008810:Mice, Inbred C57BL; D009026:Mortality; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology*; D014302:Trinitrobenzenesulfonic Acid / Q000008:administration & dosage / Q000633:toxicity; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*; D015431:Weight Loss
D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D014302:Trinitrobenzenesulfonic Acid