[Towards bacterial detection in labile blood products].
Bacterial contamination of blood components represents today the highest infectious risk in blood transfusion, the risk is particularly high when it affects platelet concentrates. The prevention methods developed over the past ten years (donor selection, phlebotomy site preparation, first 30 ml diversion, systematic leuko-reduction...) which aimed at limiting the introduction of bacteria in donations and bacterial proliferation, has reduced the risk of transfusion reaction due to the bacterial contamination. Improving strategies for reducing the risks of bacterial contamination is one of the priorities of the French National Blood Transfusion Service (l'Etablissement français du sang - EFS). It is essential to improve existent prevention methods and develop the implication of all the actors (from donation to transfusion) involved in the prevention of this risk. Bacterial detection or pathogens inactivation are now available and are able to reduce (for detection) or prevent (for inactivation) the occurrence of reaction due to bacterial contamination of PC. Up to now, the choice is in favour of bacterial detection. Three methods (BacT/Alert, BioMerieux; eBDS, Pall; ScanSystem, Hemosystem) of detection of bacterial contamination in PC can be generalised now. Adaptations, need for their implementation are acceptable, especially concerning PC availability.
Morel
P
P
Etablissement français du Sang-Bourgogne-Franche-Comté, Besançon, France. pascal.morel@efs.sante.fr
D001331:Automation; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development / Q000302:isolation & purification* / Q000528:radiation effects; D001431:Bacteriological Techniques / Q000295:instrumentation; D001769:Blood / Q000382:microbiology* / Q000821:virology; D016913:Blood Component Transfusion; D001803:Blood Transfusion; D004866:Equipment Contamination; D005602:France; D006292:Health Priorities; D006801:Humans; D017053:Infection Control / Q000331:legislation & jurisprudence / Q000379:methods*; D010101:Oxygen Consumption; D012306:Risk; D012867:Skin / Q000382:microbiology; D013242:Sterilization / Q000379:methods; D014780:Viruses / Q000528:radiation effects