title: Acinetobacter baumannii: emergence and spread in Israeli hospitals 1997-2002.
abstract: The incidence of multi-drug-resistant Acinetobacter baumannii bloodstream infections (BSIs) increased two- to four-fold in three Israeli hospitals between 1997 and 2002, accounting for 3.5-18% of all hospital-acquired BSIs. This was associated with increasing carbapenem resistance reaching 35-54%, and by a dramatic increase in carbapenem consumption. In-hospital fatality rates ranged between 47% and 58% and were significantly higher than those seen with other nosocomial Gram-negative pathogens. A. baumannii was not restricted to intensive care units, but had spread to all hospital wards. Multi-drug-resistant A. baumannii has the potential to reach endemicity in hospitals and warrants more vigorous and innovative efforts to limit its spread.
authors.affiliation: Department of Medicine and Infectious Diseases, Rabin Medical Centre, Beilinson Campus, Petach-Tikva, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. pil1pel@zahav.net.il
authors.forename: M
authors.initials: M
authors.lastname: Paul
authors.forename: M
authors.initials: M
authors.lastname: Weinberger
authors.forename: Y
authors.initials: Y
authors.lastname: Siegman-Igra
authors.forename: T
authors.initials: T
authors.lastname: Lazarovitch
authors.forename: I
authors.initials: I
authors.lastname: Ostfeld
authors.forename: I
authors.initials: I
authors.lastname: Boldur
authors.forename: Z
authors.initials: Z
authors.lastname: Samra
authors.forename: H
authors.initials: H
authors.lastname: Shula
authors.forename: Y
authors.initials: Y
authors.lastname: Carmeli
authors.forename: B
authors.initials: B
authors.lastname: Rubinovitch
authors.forename: S
authors.initials: S
authors.lastname: Pitlik
mesh_terms: D000151:Acinetobacter Infections / Q000453:epidemiology* / Q000401:mortality; D040981:Acinetobacter baumannii / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity*; D015780:Carbapenems / Q000494:pharmacology; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D004196:Disease Outbreaks; D024881:Drug Resistance, Bacterial; D017052:Hospital Mortality; D006801:Humans; D015994:Incidence; D007557:Israel / Q000453:epidemiology
chemical_list: D015780:Carbapenems