title: Deoxyribozyme-based ligase logic gates and their initial circuits.
abstract: A complete set (YES, NOT, AND, and ANDNOT) of molecular scale logic gates based on ligase deoxyribozymes was constructed. The activity of these gates was visualized through the formation of cascades with downstream phosphodieseterase YES gates, which performed fluorogenic cleavage.
authors.affiliation: Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, Columbia University, Box 84, 630 West 168th Street, New York, NY 10032, USA. mns18@columbia.edu
authors.forename: Milan N
authors.initials: MN
authors.lastname: Stojanovic
authors.forename: Stanka
authors.initials: S
authors.lastname: Semova
authors.forename: Dmitry
authors.initials: D
authors.lastname: Kolpashchikov
authors.forename: Joanne
authors.initials: J
authors.lastname: Macdonald
authors.forename: Clint
authors.initials: C
authors.lastname: Morgan
authors.forename: Darko
authors.initials: D
authors.lastname: Stefanovic
mesh_terms: D001483:Base Sequence; D002384:Catalysis; D011088:DNA Ligases / Q000737:chemistry* / Q000378:metabolism; D021881:DNA, Catalytic / Q000737:chemistry* / Q000378:metabolism; D008128:Logic; D008969:Molecular Sequence Data; D009841:Oligonucleotides / Q000737:chemistry / Q000378:metabolism
chemical_list: D021881:DNA, Catalytic; D009841:Oligonucleotides; D011088:DNA Ligases