title: Survival after pediatric liver transplantation: why does living donation offer an advantage?
abstract: OBJECTIVE
  Living donor liver transplantation (LDLT) results in improved survival compared with deceased whole and split organ transplantation in children.
  
  
  OBJECTIVE
  To evaluate the effect of LDLT on graft and patient survival in pediatric liver transplantation.
  
  
  METHODS
  Retrospective cohort.
  
  
  METHODS
  Data included all pediatric recipients (aged <18 years) registered in the UNOS (United Network for Organ Sharing) database from October 1, 1987, to May 24, 2004. Covariates predictive of survival by univariate analyses were included in the Cox proportional hazards regression models in a blockwise fashion to determine predictors of survival.
  
  
  RESULTS
  Kaplan-Meier graft and patient survival rates were improved in LDLT recipients compared with recipients of deceased whole and split organ transplantations (P<.01). In the initial model (model P<.001), prognostic factors for graft and patient survival included recipient age, race, origin of liver disease, certain pretransplantation laboratory data, medical condition, multiorgan transplantation, retransplantation, recipient-donor ABO blood compatibility, and cold and warm ischemia times. The addition of graft type to the initial covariate set did not significantly change the model (P = .21, covariate P = .09). However, most of the positive prognostic factors identified in the model were inherent characteristics of LDLT recipients and the LDLT procedure.
  
  
  CONCLUSIONS
  Graft and patient survival in the pediatric population is better with LDLT than deceased organ transplantation. Factors that contribute to this difference include recipients who are less ill, who have shorter cold and warm ischemia times, and those with a decreased need for retransplantation but not the type of graft per se.
authors.affiliation: Department of Surgery, Vanderbilt University Medical Center, Nashville, Tenn, USA. mary.austin@vanderbilt.edu
authors.forename: Mary T
authors.initials: MT
authors.lastname: Austin
authors.forename: Irene D
authors.initials: ID
authors.lastname: Feurer
authors.forename: Ravi S
authors.initials: RS
authors.lastname: Chari
authors.forename: D Lee
authors.initials: DL
authors.lastname: Gorden
authors.forename: J Kelly
authors.initials: JK
authors.lastname: Wright
authors.forename: C Wright
authors.initials: CW
authors.lastname: Pinson
mesh_terms: D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006085:Graft Survival; D006801:Humans; D008107:Liver Diseases / Q000401:mortality / Q000601:surgery; D016031:Liver Transplantation / Q000401:mortality*; D019520:Living Donors; D008297:Male; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D016019:Survival Analysis; D015996:Survival Rate