title: Significance of benign endometrial cells in papanicolaou tests from women aged >or=40 years.
abstract: BACKGROUND
  The 2001 Bethesda System recommends reporting benign endometrial cells (BECs) in women aged >or=40 years and considers these women at risk for endometrial pathology. The current study examines the relative risk of hyperplasia or malignancy conferred by the presence versus the absence of BECs in Papanicolaou (Pap) tests of women aged >or=40 years.
  
  
  METHODS
  Women aged >or=40 years represented 29,177 (46.2%) of 63,202 Pap tests obtained over 1 year from a largely suburban screened population. Of these, 866 Pap tests (3%) showed BECs. Over the same 1 year period, 789 women aged >or=40 years had endometrial histologic evaluations between 14 days and 6 months following a Pap test. The Pap tests of 159 women had BECs, and 33 had atypical (n=32) or malignant (n=1) endometrial cells. The 597 remaining women, who had Pap tests without endometrial cells but who had endometrial sampling for other reasons, served as controls.
  
  
  RESULTS
  There were nine endometrial hyperplasias (5.7%) and no adenocarcinomas in the BECs group, whereas 34 hyperplasias (5.7%) and 6 adenocarcinomas (1%) were diagnosed in the controls. These differences were not statistically significant, even after restricting the analysis to women aged >or=50 years or to women known to be postmenopausal.
  
  
  CONCLUSIONS
  The current study found that women aged >or=40 years with BECs in their Pap tests did not have more endometrial hyperplasias or malignancies when compared with women who had endometrial sampling for reasons other than the presence of endometrial cells in a Pap test.
authors.affiliation: Department of Laboratory Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Thrall
authors.forename: Klint S
authors.initials: KS
authors.lastname: Kjeldahl
authors.forename: Kay
authors.initials: K
authors.lastname: Savik
authors.forename: H Evin
authors.initials: HE
authors.lastname: Gulbahce
authors.forename: Stefan E
authors.initials: SE
authors.lastname: Pambuccian
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000328:Adult; D017677:Age Distribution; D004714:Endometrial Hyperplasia / Q000473:pathology*; D016889:Endometrial Neoplasms / Q000473:pathology*; D004717:Endometrium / Q000166:cytology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D065006:Papanicolaou Test; D011379:Prognosis; D014626:Vaginal Smears