Analysis of an interaction threshold in a mixture of drugs and/or chemicals.
Increasingly, humans are exposed to drug/chemical mixtures. These exposures can result from therapeutic interventions or environmental sources. Of interest is the interaction that may occur among the components of these mixtures. Since interaction can be dose-dependent, it is important to determine exposure levels to either exploit the benefits of the interaction in a therapeutic application or to avoid the effect of the interaction in the case of an environmental risk assessment. We propose generalized linear models that permit the estimation of interaction threshold boundaries. The methods developed are applied to the combination of ethanol and chloral hydrate.
Hamm
Adam K
AK
Rho, Inc., Chapel Hill, NC 27514, USA.
Hans Carter
W
W
Gennings
Chris
C
D000818:Animals; D002697:Chloral Hydrate / Q000494:pharmacology; D003627:Data Interpretation, Statistical; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D016014:Linear Models; D051379:Mice; D008954:Models, Biological
D004338:Drug Combinations; D000431:Ethanol; D002697:Chloral Hydrate