title: Cholesteryl ester transfer protein (CETP) I405V polymorphism and longevity in Italian centenarians.
abstract: A common polymorphism (I405V) in exon 14 of the cholesteryl ester transfer protein (CETP) gene has been recently associated to healthy aging in Ashkenazi Jewish. In order to study this genetic effect in long-lived individuals with a different ethnicity, we analyzed the allele and genotype distributions of the CETP polymorphism a sample of Italian centenarians. Our result does not confirm the association between the I405V CETP variation and the healthy aging phenotype described in the Ashkenazi Jewish population and suggests that other gene environment interactions contribute to longevity.
authors.affiliation: Department of Neurological and Psychiatric Sciences, University of Florence, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Cellini
authors.forename: Benedetta
authors.initials: B
authors.lastname: Nacmias
authors.forename: Fabiola
authors.initials: F
authors.lastname: Olivieri
authors.forename: Luigi
authors.initials: L
authors.lastname: Ortenzi
authors.forename: Andrea
authors.initials: A
authors.lastname: Tedde
authors.forename: Silvia
authors.initials: S
authors.lastname: Bagnoli
authors.forename: Concetta
authors.initials: C
authors.lastname: Petruzzi
authors.forename: Claudio
authors.initials: C
authors.lastname: Franceschi
authors.forename: Sandro
authors.initials: S
authors.lastname: Sorbi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002352:Carrier Proteins / Q000235:genetics*; D053480:Cholesterol Ester Transfer Proteins; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D007438:Introns / Q000235:genetics*; D007558:Italy; D007585:Jews; D008136:Longevity / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D006023:Glycoproteins