Effect of ambroxol, spirulina and vitamin-E in naphthalene induced cataract in female rats.
Anticataract activity of Ambroxol, Spirulina and Vitamin E was examined using the naphthalene cataract model. Adult female albino rats of Wistar strain weighing between 180 and 220 grams were taken and divided into eight groups. Group I received light liquid paraffin 5 ml/kg/ day p.o. for 6 weeks. Group II received naphthalene solution 0.5 gm/kg/ day p.o. for first three days and 1 gm/kg/day p.o. thereafter for six weeks. Group III received Ambroxol suspension in 0.5% carboxy methyl cellulose (CMC) at the dose of 100 mg/kg/day p.o. alongwith naphthalene. Group IV received Spirulina in distilled water at the dose of 1500 mg/kg/ day p.o. alongwith naphthalene. Group V received Vitamin E emulsion at the dose of 50 mg/kg/day p.o. alongwith naphthalene. Group VI received Ambroxol alone at the dose of 100 mg/kg/day p.o. Group VII received Spirulina alone at the dose of 1500 mg/kg/day p.o. Group VIII received vitamin E alone at the dose of 50 mg/kg/day p.o. Lens glutathione, soluble protein and water content profiles revealed the preventive role of Ambroxol, Spirulina and Vitamin E in naphthalene-induced cataract in female rats.
Haque
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Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi - 110 062.
Gilani
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KM
D000551:Ambroxol / Q000627:therapeutic use*; D000818:Animals; D001426:Bacterial Proteins / Q000627:therapeutic use*; D002386:Cataract / Q000139:chemically induced* / Q000188:drug therapy / Q000517:prevention & control*; D005260:Female; D009281:Naphthalenes / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D053545:Spirulina; D014810:Vitamin E / Q000627:therapeutic use*
D001426:Bacterial Proteins; D009281:Naphthalenes; D014810:Vitamin E; D000551:Ambroxol; C031721:naphthalene