title: A marker of oxidative stress in saliva: association with periodontally-involved teeth of a hopeless prognosis.
abstract: The aim of this study was to determine the association between levels of a marker of oxidative stress, 8-hydroxydeoxyguanosine (8-OHdG), in saliva and the presence of teeth with a hopeless prognosis as a result of advanced periodontitis. Thirty-four periodontitis patients were divided into two groups based on the presence or absence of periodontally-involved teeth of hopeless prognosis. Salivary levels of 8-OHdG in those with were significantly higher than in subjects without periodontally-involved teeth of hopeless prognosis (4.78 +/- 0.14 ng/ml and 2.35 +/- 0.18 ng/ml, respectively). We also evaluated 8-OHdG levels in gingival crevicular fluid (GCF) of teeth with advanced periodontal destruction (mean probing depth = 7.2). In this case, 8-OHdG was detected only from those periodontally-involved teeth of hopeless prognosis, and only in some cases (8 out of 18 samples). These data suggest that periodontally-involved teeth of hopeless prognosis are a major source of salivary 8-OHdG. Measurement of salivary 8-OHdG levels may prove to be useful in identifying patients with teeth of hopeless prognosis.
authors.affiliation: Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Takane
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Sugano
authors.forename: Tsunehiro
authors.initials: T
authors.lastname: Ezawa
authors.forename: Toshio
authors.initials: T
authors.lastname: Uchiyama
authors.forename: Koichi
authors.initials: K
authors.lastname: Ito
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000378:metabolism; D015415:Biomarkers / Q000032:analysis; D016022:Case-Control Studies; D002908:Chronic Disease; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism*; D018450:Disease Progression; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D010518:Periodontitis / Q000378:metabolism*; D011379:Prognosis; D012463:Saliva / Q000737:chemistry*; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine