HIV-dementia, Tat-induced oxidative stress, and antioxidant therapeutic considerations.
Oxidative stress is thought to play a role in the onset of dementia. HIV-dementia has recently been demonstrated to be associated with oxidative stress as indexed by increased protein and lipid peroxidation in the brain and cerebrospinal fluid compared to HIV non-demented patients. The HIV protein Tat induces neurotoxicity, and, more recently, Tat was found to induce oxidative stress directly and indirectly. The role of Tat in HIV-dementia and possible therapeutic strategies involving endogenous and exogenous antioxidants are discussed.
Pocernich
Chava B
CB
Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA.
Sultana
Rukhsana
R
Mohmmad-Abdul
Hafiz
H
Nath
Avindra
A
Butterfield
D Allan
DA
D015526:AIDS Dementia Complex / Q000188:drug therapy*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D015696:Gene Products, tat / Q000633:toxicity*; D006801:Humans; D008954:Models, Biological; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D054322:tat Gene Products, Human Immunodeficiency Virus
D000975:Antioxidants; D015696:Gene Products, tat; D054322:tat Gene Products, Human Immunodeficiency Virus