title: Insulin independence after living-donor distal pancreatectomy and islet allotransplantation.
abstract: Rising demand for islet transplantation will lead to severe donor shortage in the near future, especially in countries where cadaveric organ donation is scarce. We undertook a successful transplantation of living-donor islets for unstable diabetes. The recipient was a 27-year-old woman who had had brittle, insulin-dependent diabetes mellitus for 12 years. The donor, who was a healthy 56-year-old woman and mother of the recipient, underwent a distal pancreatectomy. After isolation, 408 114 islet equivalents were transplanted immediately. The transplants functioned immediately and the recipient became insulin-independent 22 days after the operation. The donor had no complications and both women showed healthy glucose tolerance. Transplantation of living-donor islets from the distal pancreas can be sufficient to reverse brittle diabetes.
authors.affiliation: Kyoto University Hospital Transplantation Unit, Kyoto Japan. shinichi@kuhp.kyoto-u.ac.jp
authors.forename: Shinichi
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Teru
authors.initials: T
authors.lastname: Okitsu
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Iwanaga
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Noguchi
authors.forename: Hideo
authors.initials: H
authors.lastname: Nagata
authors.forename: Yukihide
authors.initials: Y
authors.lastname: Yonekawa
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Yamada
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Fukuda
authors.forename: Katsushi
authors.initials: K
authors.lastname: Tsukiyama
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Suzuki
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kawasaki
authors.forename: Makiko
authors.initials: M
authors.lastname: Shimodaira
authors.forename: Keiko
authors.initials: K
authors.lastname: Matsuoka
authors.forename: Toshiya
authors.initials: T
authors.lastname: Shibata
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Kasai
authors.forename: Taira
authors.initials: T
authors.lastname: Maekawa
authors.forename: James
authors.initials: J
authors.lastname: Shapiro
authors.forename: Koichi
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000601:surgery*; D005260:Female; D006801:Humans; D016381:Islets of Langerhans Transplantation; D019520:Living Donors; D008875:Middle Aged; D010180:Pancreatectomy / Q000379:methods*; D010195:Pancreatitis / Q000150:complications; D020858:Tissue and Organ Harvesting / Q000379:methods*