title: Identification of a new HLA-DRB1 allele, HLA-DRB1*1212, and confirmation of HLA-B*1586*.
abstract: A novel allele, HLA-DRB1*1212, was identified by sequence-based typing. DRB1*1212 was identical to DRB*120101 at exon 2 except for a single nucleotide at position 199 from A to C, leading to amino acidic substitution from Ile to Leu at codon 67. We also confirmed the HLA-B*1586 in another Chinese person.
authors.affiliation: HLA Typing Laboratory, Blood Center of Zhejiang Province, Hangzhou, Zhejiang Province, China. qxk@zjb.org.cn
authors.forename: L-X
authors.initials: LX
authors.lastname: Yan
authors.forename: F-M
authors.initials: FM
authors.lastname: Zhu
authors.forename: Q-F
authors.initials: QF
authors.lastname: Lv
authors.forename: W
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000483:Alleles; D001483:Base Sequence; D003062:Codon; D017931:DNA Primers / Q000235:genetics; D005091:Exons; D015235:HLA-B Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006650:Histocompatibility Testing; D006801:Humans; D007532:Isoleucine / Q000737:chemistry; D007930:Leucine / Q000737:chemistry; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D012689:Sequence Homology, Nucleic Acid
chemical_list: D003062:Codon; D017931:DNA Primers; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C553515:HLA-DRB1*12:12 antigen; D007532:Isoleucine; D007930:Leucine