title: Association of the myeloperoxidase -468G-->A polymorphism with gastric inflammation and duodenal ulcer risk.
abstract: OBJECTIVE
  To elucidate the relations between the myeloperoxidase (-468)G-->A polymorphism and the development of duodenal ulcer (DU), and to investigate the impacts of this host genetic polymorphism on the histopathological features of Helicobacter pylori (H pylori)-related gastritis.
  
  
  METHODS
  In a case-control study of 115 consecutive DU patients and 182 controls, the myeloperoxidase (-468)G-->A polymorphism was genotyped. Additionally, gastric mucosal changes were examined according to the updated Sydney System.
  
  
  RESULTS
  The two study groups differed in the distributions of myeloperoxidase genotypes (P = 0.008). All six individuals carrying myeloperoxidase A/A genotypes were in the DU group. The carriage of myeloperoxidase allele A and H pylori infection were associated with an increased risk of DU with odds ratios (OR) of 2.3 and 5.8, respectively. The combined risk of the carriage of myeloperoxidase allele A and H pylori infection for DU was 8.7 (95% CI, 3.5-21.8). In the H pylori-infected individuals, allele A carriers displayed higher bacterial density scores (P = 0.04) in the antrum than did non-carriers.
  
  
  CONCLUSIONS
  This work verifies for the first time the association of myeloperoxidase (-468)G-->A polymorphism with antral H pylori density and DU disease. The mechanisms underlying this genetic polymorphism in developing DU disease merit further investigations.
authors.affiliation: Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan, China.
authors.forename: Ping-I
authors.initials: PI
authors.lastname: Hsu
authors.forename: Jyh-Jen
authors.initials: JJ
authors.lastname: Jwo
authors.forename: Hui-Hwa
authors.initials: HH
authors.lastname: Tseng
authors.forename: Kwok-Hung
authors.initials: KH
authors.lastname: Lai
authors.forename: Gin-Ho
authors.initials: GH
authors.lastname: Lo
authors.forename: Ching-Chu
authors.initials: CC
authors.lastname: Lo
authors.forename: Chung-Jen
authors.initials: CJ
authors.lastname: Wu
authors.forename: Seng-Kee
authors.initials: SK
authors.lastname: Chuah
authors.forename: Il-Ran
authors.initials: IR
authors.lastname: Hwang
authors.forename: Jin-Liang
authors.initials: JL
authors.lastname: Chen
authors.forename: Yu-Shan
authors.initials: YS
authors.lastname: Chen
authors.forename: Angela
authors.initials: A
authors.lastname: Chen
mesh_terms: D000225:Adenine; D000328:Adult; D000368:Aged; D004381:Duodenal Ulcer / Q000235:genetics*; D005260:Female; D005756:Gastritis / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006147:Guanine; D006801:Humans; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000235:genetics*
chemical_list: D006147:Guanine; D009195:Peroxidase; D000225:Adenine