Antiinflammatory activity of the pectic polysaccharide from Comarum palustre.
A pectic polysaccharide named comaruman (CP) was extracted from the aerial part of Comarum palustre with 0.7% aqueous ammonium oxalate and subsequent precipitation with ethanol. Oral administration of comaruman (5-100 mg/kg) was found to reduce a paw edema observed 24 h after injection of 2% formalin in mice. A fraction of comaruman (CP-H9) exhibited a similar antiinflammatory activity. Comaruman, CP deprived of lipid, CP purified by proteins and CP fractions obtained with acidic hydrolysis inhibit spontaneous and phorbol-12-myristate-13-acetate-activated adhesion of peritoneal leukocytes in vitro.
Popov
S V
SV
Institute of Physiology, Komi Science Centre, The Urals Branch of the Russian Academy of Sciences, 50, Pervomaiskaya Str., 167982 Syktyvkar, Republic Komi, Russia. popov@physiol.komisc.ru
Popova
G Yu
GY
Ovodova
R G
RG
Ovodov
Yu S
YS
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000188:drug therapy; D007213:Indomethacin / Q000494:pharmacology; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D010368:Pectins / Q000737:chemistry / Q000494:pharmacology*; D010529:Peritoneal Cavity / Q000166:cytology; D035261:Plant Components, Aerial; D027824:Rosaceae / Q000737:chemistry*
D000893:Anti-Inflammatory Agents; C501873:comaruman; D010368:Pectins; D007213:Indomethacin