title: Differences in the proportions of fluoroquinolone-resistant Gram-negative bacteria isolated from bacteraemic children with cancer in two Italian centres.
abstract: The proportion of ciprofloxacin-resistant Gram-negative bacteria isolated from the blood of children with cancer (not receiving prophylaxis) was 10% in a paediatric hospital (Genoa) where the use of quinolones was highly restricted, compared with 41% in a department of haematology (Rome) where leukaemic adults, who received fluoroquinolone prophylaxis, were also treated (p < 0.0001). Moreover, simultaneous resistance to ciprofloxacin and ceftazidime, amikacin or imipenem-cilastatin was 11% in Genoa compared with 37% in Rome (p < 0.001). Ciprofloxacin resistance was more frequent in children who shared an environment with adults who were receiving ciprofloxacin prophylaxis.
authors.affiliation: Infectious Diseases Unit, Department of Hematology and Oncology, G. Gaslini Teaching Hospital, Genoa, Italy. eliocastagnola@ospedale-gaslini.ge.it
authors.forename: E
authors.initials: E
authors.lastname: Castagnola
authors.forename: R
authors.initials: R
authors.lastname: Haupt
authors.forename: A
authors.initials: A
authors.lastname: Micozzi
authors.forename: I
authors.initials: I
authors.lastname: Caviglia
authors.forename: A M
authors.initials: AM
authors.lastname: Testi
authors.forename: F
authors.initials: F
authors.lastname: Giona
authors.forename: S
authors.initials: S
authors.lastname: Parodi
authors.forename: C
authors.initials: C
authors.lastname: Girmenia
mesh_terms: D000583:Amikacin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016470:Bacteremia / Q000382:microbiology* / Q000517:prevention & control; D002442:Ceftazidime / Q000494:pharmacology; D002648:Child; D002939:Ciprofloxacin / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial; D024841:Fluoroquinolones / Q000494:pharmacology* / Q000627:therapeutic use; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology* / Q000517:prevention & control; D006776:Hospitals, Pediatric; D006801:Humans; D015378:Imipenem / Q000494:pharmacology; D007558:Italy; D009369:Neoplasms / Q000097:blood / Q000150:complications*; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D002939:Ciprofloxacin; D015378:Imipenem; D000583:Amikacin; D002442:Ceftazidime