Conductimetric determination of phenylpropanolamine HCl, ranitidine HCl, hyoscyamine HBr and betaine HCl in their pure state and pharmaceutical preparations.
Sodium tetraphenylborate and phosphotungstic acid were used as titrants for the conductimetric determination of phenylpropanolamine HCl (PPA.Cl), ranitidine HCl (Ra.Cl), hyoscyamine HBr (Hy.Br) and betaine HCl (Be.Cl) through ion-associate complex formation. The molar combining ratio and the solubility products of the formed ion-associates were studied and calculated. The suggested method has been applied to the determination of the mentioned drugs in their pure state and pharmaceutical preparations with mean recovery values of 97.71-102.97% and relative standard deviations 0.25-0.85%. The accuracy of the method is indicated by excellent recovery and low standard deviation. The results are compared with the pharmacopoeial or the official methods.
Issa
Yousry M
YM
Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt. yousrymi@link.net
Youssef
Ahmed F A
AF
Mutair
Ali A
AA
D001285:Atropine / Q000032:analysis*; D001622:Betaine / Q000032:analysis*; D002214:Capsules; D004563:Electrochemistry / Q000295:instrumentation / Q000379:methods; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010665:Phenylpropanolamine / Q000032:analysis*; D011899:Ranitidine / Q000032:analysis*; D015203:Reproducibility of Results; D012995:Solubility
D002214:Capsules; D004364:Pharmaceutical Preparations; D010665:Phenylpropanolamine; D001622:Betaine; D001285:Atropine; D011899:Ranitidine