Nicotine modulates dopamine synthesis rate as determined by L-[beta-11C]DOPA: PET studies compared with [11C]raclopride binding in the conscious monkey brain.
Tsukada
Hideo
H
Central Research Laboratory, Hamamatsu Photonics K.K., Hamakita, Shizuoka 434-8601, Japan. tsukada@crl.hpk.co.jp
Miyasato
Katsumasa
K
Harada
Norihiro
N
Nishiyama
Shingo
S
Fukumoto
Dai
D
Kakiuchi
Takeharu
T
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism; D002250:Carbon Radioisotopes; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism; D003243:Consciousness / Q000502:physiology; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism; D016291:Dizocilpine Maleate / Q000378:metabolism / Q000493:pharmacokinetics; D004298:Dopamine / Q000096:biosynthesis*; D018492:Dopamine Antagonists / Q000378:metabolism / Q000493:pharmacokinetics; D018691:Excitatory Amino Acid Antagonists / Q000378:metabolism / Q000493:pharmacokinetics; D007980:Levodopa / Q000378:metabolism* / Q000493:pharmacokinetics; D008253:Macaca mulatta; D008297:Male; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism; D009538:Nicotine / Q000494:pharmacology*; D049268:Positron-Emission Tomography / Q000379:methods*; D017729:Presynaptic Terminals / Q000187:drug effects / Q000378:metabolism; D020891:Raclopride / Q000378:metabolism* / Q000493:pharmacokinetics; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
D002250:Carbon Radioisotopes; D018492:Dopamine Antagonists; D018691:Excitatory Amino Acid Antagonists; D020891:Raclopride; D007980:Levodopa; D016291:Dizocilpine Maleate; D009538:Nicotine; D000109:Acetylcholine; D004298:Dopamine