title: [Molecular mechanisms of vitamin K action in the bone homeostasis].
abstract: Vitamin K is used as an anti-osteoporosis drug in Japan. Moreover, vitamin K intake has been found to decrease hip fracture risk. In the bone homeostasis, vitamin K action is mediated through two molecular mechanisms: posttranslational modification of proteins, and regulation of gene expression. The former is vitamin K-dependent carboxylation, in which vitamin K functions as an essential cofactor for modification of glutamic acid residues to gamma-carboxyglutamic acid residues. The latter is a novel mechanism that regulates the transcription of target genes by vitamin K through activation of steroid and xenobiotic receptor (SXR). The two mechanisms may coordinately contribute to vitamin K function in the bone metabolism.
authors.affiliation: Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical School.
authors.forename: Tomoe
authors.initials: T
authors.lastname: Ichikawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Inoue
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000187:drug effects*; D002264:Carboxylic Acids / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism; D006801:Humans; D010024:Osteoporosis / Q000188:drug therapy; D011987:Receptors, Steroid / Q000502:physiology; D014812:Vitamin K / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D002264:Carboxylic Acids; D005971:Glutamates; D011987:Receptors, Steroid; D014812:Vitamin K