title: Stage-specific changes in gene expression in acutely isolated mouse CNS progenitor cells.
abstract: Neural progenitor cells can be derived from a variety of developmental stages when they are preferentially proliferating, undergoing neurogenesis or undergoing gliogenesis. We used FACS sorting and the LeX surface marker to enrich neural progenitor cells from different embryonic stages and adult and compared their gene expression profiles using Affymetrix Microarrays. Our results show that, while there are common genes expressed in the progenitor cell population from all stages, there are also significant differences in gene expression patterns that correlate with stage-related behaviors. These data indicate that progenitor cells change during development and that adult and embryonic neural progenitor cells are intrinsically different.
authors.affiliation: Center for Neuropharmacology and Neuroscience, Albany Medical College, NY 12208, USA. abramon@mail.amc.edu
authors.forename: Natalia
authors.initials: N
authors.lastname: Abramova
authors.forename: Carol
authors.initials: C
authors.lastname: Charniga
authors.forename: Susan K
authors.initials: SK
authors.lastname: Goderie
authors.forename: Sally
authors.initials: S
authors.lastname: Temple
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D005260:Female; D020869:Gene Expression Profiling; D016256:Lewis X Antigen / Q000096:biosynthesis; D008297:Male; D051379:Mice; D009457:Neuroglia / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D012333:RNA, Messenger / Q000096:biosynthesis; D013234:Stem Cells / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D016256:Lewis X Antigen; D012333:RNA, Messenger