Cortical lesions and brain atrophy in MS.
Multiple sclerosis is generally considered a disease of the white matter. However, this is only one pathological aspect of the disease as demyelination is prominent in the grey matter of deep cerebral nuclei and the cerebral cortex. In this review, we discuss the possibility that disease involvement of grey matter structures may significantly contribute to clinical disability in multiple sclerosis patients.
Kutzelnigg
Alexandra
A
Department of Neuroimmunology, Center for Brain Research Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria.
Lassmann
Hans
H
D001284:Atrophy; D001927:Brain Diseases / Q000150:complications / Q000473:pathology*; D003711:Demyelinating Diseases / Q000473:pathology*; D006801:Humans; D009103:Multiple Sclerosis / Q000150:complications / Q000473:pathology*