Synthesis and pharmacology of new camptothecin drugs.
Camptothecin (CPT) drugs exhibit antineoplastic activity against colorectal, breast, lung and ovarian cancers. This review briefly summarizes the pharmacology of CPT drugs, examines four strategies and methods for the synthesis of camptothecins, and finally discusses homocamptothecins and silatecans, two new classes of CPT analog.
Driver
Russell W
RW
Radiology Laboratory, California Pacific Medical Center Research Institute, San Francisco, CA 94118, USA.
Yang
Li-Xi
LX
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000494:pharmacology*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D017646:Organosilicon Compounds / Q000138:chemical synthesis / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D017646:Organosilicon Compounds; C120029:homocamptothecin; D002166:Camptothecin