Effects of intraperitoneally injected lithium, imipramine and diazepam on nitrate levels in rat amygdala.
Nitric oxide (NO) has been studied in relation to the etiologies of various neurologic and psychiatric diseases. However, little is known about whether clinically available psychotropic drugs affect the NO system in the brain. Using an in vivo brain microdialysis method, the effects of intraperitoneally administered lithium, imipramine and diazepam on levels of , a marker of in vivo NO production, were investigated in the rat amygdala. Lithium significantly reduced, while imipramine raised, levels as compared with controls. These observations suggest that lithium and imipramine induce opposite effects on NO-related systems in the brain.
Maruta
Shuji
S
Department of Psychiatry, Kitasato University School of Medicine, Kanagawa, Japan.
Suzuki
Eiji
E
Yokoyama
Masamoto
M
Sato
Taku
T
Inada
Ken
K
Watanabe
Shigeru
S
Miyaoka
Hitoshi
H
D000679:Amygdala / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000494:pharmacology*; D018692:Antimanic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D003975:Diazepam / Q000008:administration & dosage / Q000494:pharmacology*; D007099:Imipramine / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008094:Lithium / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009566:Nitrates / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D026361:Reactive Nitrogen Species / Q000378:metabolism
D014151:Anti-Anxiety Agents; D000929:Antidepressive Agents, Tricyclic; D018692:Antimanic Agents; D009566:Nitrates; D026361:Reactive Nitrogen Species; D009569:Nitric Oxide; D008094:Lithium; D007099:Imipramine; D003975:Diazepam