title: Regulation of dendritic development by neuronal activity.
abstract: Proper development of dendrites is essential for the establishment of neuronal circuitry. The elaboration of the dendritic tree is a highly dynamic and regulated process, which involves the formation of new branches as well as the maintenance or elimination of pre-existing branches. This review describes recent advances in our understanding of the molecular mechanisms of activity-dependent dendritic development. Neuronal activity triggers calcium-mediated signaling events that affect the structural components of dendrites and adhesion molecules. These calcium-induced signaling pathways also target nuclear transcription factors thereby controlling expression of genes required for dendritic development. Thus, a coordinated response to calcium-regulated signaling pathways mediates activity-dependent dendritic development.
authors.affiliation: Department of Physiology and Neuroscience, Molecular Neurobiology Program, Skirball Institute, New York University, New York 10016, USA.
authors.forename: Yachi
authors.initials: Y
authors.lastname: Chen
authors.forename: Anirvan
authors.initials: A
authors.lastname: Ghosh
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000378:metabolism; D003712:Dendrites / Q000502:physiology*; D015870:Gene Expression / Q000502:physiology; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D008959:Models, Neurological; D009474:Neurons / Q000166:cytology* / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D015815:Cell Adhesion Molecules; D003598:Cytoskeletal Proteins; D002118:Calcium