Phosphoryl transfer by aminoglycoside 3'-phosphotransferases and manifestation of antibiotic resistance.
Transfer of the gamma-phosphoryl group from ATP to aminoglycoside antibiotics by aminoglycoside 3'-phosphotransferases is one of the most important reactions for manifestation of bacterial resistance to this class of antibiotics. This review article surveys the latest structural and mechanistic findings with these enzymes.
Kim
Choonkeun
C
Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
Mobashery
Shahriar
S
D000255:Adenosine Triphosphate / Q000737:chemistry / Q000378:metabolism; D000617:Aminoglycosides / Q000737:chemistry / Q000378:metabolism*; D002240:Carbohydrate Sequence; D002384:Catalysis; D024881:Drug Resistance, Bacterial; D019868:Kanamycin Kinase / Q000378:metabolism*; D008969:Molecular Sequence Data; D010710:Phosphates / Q000378:metabolism*; D013329:Structure-Activity Relationship
D000617:Aminoglycosides; D010710:Phosphates; D000255:Adenosine Triphosphate; D019868:Kanamycin Kinase