Association of the myeloperoxidase -468G-->A polymorphism with gastric inflammation and duodenal ulcer risk.
OBJECTIVE
To elucidate the relations between the myeloperoxidase (-468)G-->A polymorphism and the development of duodenal ulcer (DU), and to investigate the impacts of this host genetic polymorphism on the histopathological features of Helicobacter pylori (H pylori)-related gastritis.


METHODS
In a case-control study of 115 consecutive DU patients and 182 controls, the myeloperoxidase (-468)G-->A polymorphism was genotyped. Additionally, gastric mucosal changes were examined according to the updated Sydney System.


RESULTS
The two study groups differed in the distributions of myeloperoxidase genotypes (P = 0.008). All six individuals carrying myeloperoxidase A/A genotypes were in the DU group. The carriage of myeloperoxidase allele A and H pylori infection were associated with an increased risk of DU with odds ratios (OR) of 2.3 and 5.8, respectively. The combined risk of the carriage of myeloperoxidase allele A and H pylori infection for DU was 8.7 (95% CI, 3.5-21.8). In the H pylori-infected individuals, allele A carriers displayed higher bacterial density scores (P = 0.04) in the antrum than did non-carriers.


CONCLUSIONS
This work verifies for the first time the association of myeloperoxidase (-468)G-->A polymorphism with antral H pylori density and DU disease. The mechanisms underlying this genetic polymorphism in developing DU disease merit further investigations.
Hsu
Ping-I
PI
Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan, China.
Jwo
Jyh-Jen
JJ
Tseng
Hui-Hwa
HH
Lai
Kwok-Hung
KH
Lo
Gin-Ho
GH
Lo
Ching-Chu
CC
Wu
Chung-Jen
CJ
Chuah
Seng-Kee
SK
Hwang
Il-Ran
IR
Chen
Jin-Liang
JL
Chen
Yu-Shan
YS
Chen
Angela
A
D000225:Adenine; D000328:Adult; D000368:Aged; D004381:Duodenal Ulcer / Q000235:genetics*; D005260:Female; D005756:Gastritis / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006147:Guanine; D006801:Humans; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000235:genetics*
D006147:Guanine; D009195:Peroxidase; D000225:Adenine