title: Synthesis and structure-activity relationships of 2-alkylidenethiazolidine-4,5-diones as antibiotic agents.
abstract: 2-Alkylidenethiazolidine-4,5-diones were prepared by novel one-pot cyclizations of arylacetonitriles with isothiocyanates and ethyl 2-chloro-2-oxoacetate. The products show antibiotic activity against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus.
authors.affiliation: Institut für Chemie, Universität Rostock, Albert-Einstein-Str. 3a, 18051 Rostock, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Albrecht
authors.forename: Dirk
authors.initials: D
authors.lastname: Gördes
authors.forename: Enrico
authors.initials: E
authors.lastname: Schmidt
authors.forename: Kerstin
authors.initials: K
authors.lastname: Thurow
authors.forename: Michael
authors.initials: M
authors.lastname: Lalk
authors.forename: Peter
authors.initials: P
authors.lastname: Langer
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D013844:Thiazoles