title: Investigation of non-uniform airflow signal oscillation during high frequency chest compression.
abstract: BACKGROUND
  High frequency chest compression (HFCC) is a useful and popular therapy for clearing bronchial airways of excessive or thicker mucus. Our observation of respiratory airflow of a subject during use of HFCC showed the airflow oscillation by HFCC was strongly influenced by the nonlinearity of the respiratory system. We used a computational model-based approach to analyse the respiratory airflow during use of HFCC.
  
  
  METHODS
  The computational model, which is based on previous physiological studies and represented by an electrical circuit analogue, was used for simulation of in vivo protocol that shows the nonlinearity of the respiratory system. Besides, airflow was measured during use of HFCC. We compared the simulation results to either the measured data or the previous research, to understand and explain the observations.
  
  
  CONCLUSIONS
  We could observe two important phenomena during respiration pertaining to the airflow signal oscillation generated by HFCC. The amplitudes of HFCC airflow signals varied depending on spontaneous airflow signals. We used the simulation results to investigate how the nonlinearity of airway resistance, lung capacitance, and inertance of air characterized the respiratory airflow. The simulation results indicated that lung capacitance or the inertance of air is also not a factor in the non-uniformity of HFCC airflow signals. Although not perfect, our circuit analogue model allows us to effectively simulate the nonlinear characteristics of the respiratory system.
  
  
  CONCLUSIONS
  We found that the amplitudes of HFCC airflow signals behave as a function of spontaneous airflow signals. This is due to the nonlinearity of the respiratory system, particularly variations in airway resistance.
authors.affiliation: Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, USA. sohn0015@umn.edu
authors.forename: Kiwon
authors.initials: K
authors.lastname: Sohn
authors.forename: Warren J
authors.initials: WJ
authors.lastname: Warwick
authors.forename: Yong W
authors.initials: YW
authors.lastname: Lee
authors.forename: Jongwon
authors.initials: J
authors.lastname: Lee
authors.forename: James E
authors.initials: JE
authors.lastname: Holte
mesh_terms: D001683:Biological Clocks / Q000502:physiology*; D035641:Chest Wall Oscillation / Q000379:methods*; D003198:Computer Simulation; D006801:Humans; D008168:Lung / Q000502:physiology*; D008954:Models, Biological; D009991:Oscillometry / Q000379:methods*; D012123:Pulmonary Ventilation / Q000502:physiology*; D015656:Respiratory Mechanics / Q000502:physiology; D013813:Therapy, Computer-Assisted / Q000379:methods*; D013909:Thorax / Q000502:physiology