"Live memory" of the cell, the other hereditary memory of living systems.
We propose to designate by the term "live memory" of the cell, the cytoplasmic memory. This phenomenon consists of non-genetic memory, but nevertheless includes transmission function, which may be "hereditary" via the ovum, from mother cell to daughter cell, or simply within the same cell from instant t to instant t+1. To understand this notion of "live memory", its role and interactions with DNA must be resituated; indeed, operational information belongs as much to the cell body and to its cytoplasmic regulatory protein components and other endogenous or exogenous ligands as it does to the DNA database. We will see in Section 2, using examples from recent experiments in biology, the principal roles of "live memory" in relation to the four aspects of cellular identity, memory of form, hereditary transmission and also working memory.
Bentolila
Simone
S
IGM, University Marne la Vallée-Cité Descartes, 5 Bd Descartes, Champs sur Marne, 77454 Marne la Vallée Cedex 2, France. tolila@infobiogen.fr
D000818:Animals; D003585:Cell Biology; D003001:Cloning, Molecular; D019295:Computational Biology / Q000379:methods*; D003593:Cytoplasm / Q000378:metabolism / Q000502:physiology*; D003599:Cytoskeleton / Q000378:metabolism; D004247:DNA / Q000235:genetics / Q000378:metabolism; D004023:Dictyostelium / Q000378:metabolism; D016678:Genome; D006801:Humans; D008568:Memory; D008957:Models, Genetic; D011328:Prions / Q000737:chemistry; D017510:Protein Folding; D012313:RNA / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology; D049490:Systems Biology / Q000379:methods; D013598:Systems Theory
D011328:Prions; D012313:RNA; D004247:DNA