title: Plasminogen activator in human gingival tissue adjacent to dental implants.
abstract: The installment of endosseous dental implants has become an accepted treatment procedure, and the long-term clinical results appear excellent. The composition of the soft tissue environment, however, is different from that around natural teeth. One characteristic of original junctional epithelium is its association with plasminogen activator (PA) activity. In 11 patients with a total of 30 ITI hollow-screw titanium dental implants, 16 biopsies were taken. Histologic cryostat sections were assayed for the presence of PA in the junctional epithelium. The results demonstrated that junctional epithelium around titanium implants yields PA activity in a manner very similar to that of natural teeth. The ability to produce this enzyme activity is not related to the developmental origin of the junctional cells, but to their position and function at the base of the gingival sulcus.
authors.affiliation: University of Berne, School of Dental Medicine, Switzerland.
authors.forename: B
authors.initials: B
authors.lastname: Schmid
authors.forename: I
authors.initials: I
authors.lastname: Spicher
authors.forename: J
authors.initials: J
authors.lastname: Schmid
authors.forename: N P
authors.initials: NP
authors.lastname: Lang
mesh_terms: D001706:Biopsy; D015921:Dental Implants; D003774:Dental Plaque Index; D017267:Dental Prosthesis Design; D004846:Epithelial Attachment / Q000201:enzymology / Q000473:pathology; D005260:Female; D005881:Gingiva / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D008297:Male; D010512:Periodontal Index; D010960:Plasminogen Activators / Q000032:analysis*; D014025:Titanium
chemical_list: D015921:Dental Implants; D014025:Titanium; D010960:Plasminogen Activators