title: Antibody titer against malondialdehyde-modified LDL compares with HDL cholesterol concentration in identifying angiographically verified coronary artery disease. Comparison of tests by ROC analysis.
abstract: Antibody titer against malondialdehyde (MDA)-modified low-density lipoprotein (LDL) has been found to be associated with atherosclerosis, but it has not been established whether it would detect subjects with coronary artery disease (CAD). In the present study, receiver-operating characteristic (ROC) analysis was used to compare the diagnostic accuracy of the antibody titer against MDA-modified LDL and high-density lipoprotein (HDL) and LDL cholesterol levels in discrimination between subjects with (n = 51) and without (n = 35) angiographically verified 3-vessel CAD. As a result, the antibody titer against MDA-modified LDL was lower in subjects with CAD compared with subjects without CAD (p < 0.0001). The area under the ROC plot was 0.822 (95% CI, 0.727 to 0.918) for the antibody titer and 0.769 (95% CI, 0.661 to 0.876) for the HDL cholesterol concentration. Both the antibody titer and the plasma HDL cholesterol level were more accurate markers of CAD than the LDL cholesterol level. As a conclusion, our results indicate that the antibody titer against MDA-modified LDL discriminates between subjects with widespread CAD and those without CAD similarly as the HDL cholesterol concentration. Moreover, the antibody titer against MDA-modified LDL is inversely correlated with the risk of severe CAD.
authors.affiliation: Laboratory of Atherosclerosis Genetics, Tampere University Hospital, Centre for Laboratory Medicine and Department of Clinical Chemistry, University of Tampere, Finland. riikka.rontu@uta.fi
authors.forename: Riikka
authors.initials: R
authors.lastname: Rontu
authors.forename: Saara
authors.initials: S
authors.lastname: Metso
authors.forename: Olli
authors.initials: O
authors.lastname: Jaakkola
authors.forename: Matti
authors.initials: M
authors.lastname: Nikkilä
authors.forename: Hannu
authors.initials: H
authors.lastname: Jokela
authors.forename: Terho
authors.initials: T
authors.lastname: Lehtimäki
mesh_terms: D000906:Antibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D008315:Malondialdehyde / Q000097:blood*; D011237:Predictive Value of Tests; D012372:ROC Curve
chemical_list: D000906:Antibodies; D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008315:Malondialdehyde