Developmental regulation of the beta-globin gene locus.
The beta-globin genes have become a classical model for studying regulation of gene expression. Wide-ranging studies have revealed multiple levels of epigenetic regulation that coordinately ensure a highly specialised, tissue- and stage-specific gene transcription pattern. Key players include cis-acting elements involved in establishing and maintaining specific chromatin conformations and histone modification patterns, elements engaged in the transcription process through long-range regulatory interactions, transacting general and tissue-specific factors. On a larger scale, molecular events occurring at the locus level take place in the context of a highly dynamic nucleus as part of the cellular epigenetic programme.
Chakalova
Lyubomira
L
Laboratory of Chromatin and Gene Expression, The Babraham Institute, Cambridge, CB2 4AT, UK.
Carter
David
D
Debrand
Emmanuel
E
Goyenechea
Beatriz
B
Horton
Alice
A
Miles
Joanne
J
Osborne
Cameron
C
Fraser
Peter
P
D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D044127:Epigenesis, Genetic; D018507:Gene Expression Regulation, Developmental; D005914:Globins / Q000235:genetics*; D006801:Humans; D038101:Insulator Elements; D019901:Locus Control Region; D046911:Macromolecular Substances; D005810:Multigene Family; D011401:Promoter Regions, Genetic; D014158:Transcription, Genetic; D019076:Transgenes
D046911:Macromolecular Substances; D005914:Globins