title: Intraluminal brachytherapy without stenting in intrahepatic papillary cholangiocarcinoma: a case report.
abstract: A 46-year-old female patient, with mild cholestasis by a large papillary cholangiocarcinoma involving the left hepatic duct, received intraluminal brachytherapy (50 Gy at 1 cm from the source axis) with the aim to relieve biliary obstruction without stent positioning. The patient presented with haemobilia and vegetant lesions in the left main biliary duct, and thus she had a high risk of early stent obstruction. Eighteen months after the treatment the patient presented tumour progression in the controlateral hepatic lobe, but had a patent left hepatic duct, without signs of cholestasis and/or cholangitis. Based on this and other published reports, intraluminal brachytherapy may be tested in a setting different from standard setting with the aim to safely palliate jaundice in patients with intraductal tumour growth in the biliary tract.
authors.affiliation: Department of Radiation Therapy, Catholic University, Campobasso, Italy. gmacchia@rm.unicatt.it
authors.forename: G
authors.initials: G
authors.lastname: Macchia
authors.forename: G
authors.initials: G
authors.lastname: Costamagna
authors.forename: A G
authors.initials: AG
authors.lastname: Morganti
authors.forename: M
authors.initials: M
authors.lastname: Mutignani
authors.forename: F
authors.initials: F
authors.lastname: Giuliante
authors.forename: G
authors.initials: G
authors.lastname: Clemente
authors.forename: F
authors.initials: F
authors.lastname: Deodato
authors.forename: D
authors.initials: D
authors.lastname: Smaniotto
authors.forename: G C
authors.initials: GC
authors.lastname: Mattiucci
authors.forename: G
authors.initials: G
authors.lastname: Sallustio
authors.forename: V
authors.initials: V
authors.lastname: Valentini
authors.forename: G
authors.initials: G
authors.lastname: Nuzzo
authors.forename: N
authors.initials: N
authors.lastname: Cellini
mesh_terms: D001650:Bile Duct Neoplasms / Q000150:complications / Q000532:radiotherapy*; D001653:Bile Ducts, Intrahepatic; D001918:Brachytherapy / Q000379:methods*; D018281:Cholangiocarcinoma / Q000150:complications / Q000532:radiotherapy*; D002779:Cholestasis / Q000209:etiology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D041781:Jaundice, Obstructive / Q000209:etiology / Q000532:radiotherapy; D008875:Middle Aged