title: The prandial insulin sensitivity-modifying effect of vagal stimulation in rats.
abstract: The effect of left cervical vagal nerve stimulation was studied on insulin sensitivity to test the proposed permissive insulin-sensitizing role of hepatic vagal parasympathetic efferent pathways in fasted and fed anesthetized rats. In fed animals, electrical stimulation (square impulses: 25 V, 5 Hz, 0.5 milliseconds over 15 minutes) of the vagal nerve induced hyperglycemia and an increase in plasma insulin immunoreactivity. Atropine (1.0 mg/kg intravenously) induced insulin resistance estimated by rapid insulin sensitivity testing. This was amplified when the vagal nerve was stimulated. The insulin-resistant state developed by fasting was not modified by either treatment with atropine or electrical stimulation. We conclude that both parasympathetic cholinergic and noncholinergic vagal efferents modulate postprandial neurogenic insulin sensitivity adjustments.
authors.affiliation: Experimental and Clinical Pharmacology Consortium, University of Debrecen, H-4032 Debrecen, Germany. barna.peitl@king.pharmacol.dote.hu
authors.forename: Barna
authors.initials: B
authors.lastname: Peitl
authors.forename: Róbert
authors.initials: R
authors.lastname: Döbrönte
authors.forename: József
authors.initials: J
authors.lastname: Németh
authors.forename: Géza
authors.initials: G
authors.lastname: Mezey
authors.forename: Péter
authors.initials: P
authors.lastname: Kovács
authors.forename: György
authors.initials: G
authors.lastname: Paragh
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Szilvássy
mesh_terms: D000818:Animals; D001285:Atropine / Q000008:administration & dosage / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism; D004435:Eating / Q000502:physiology*; D004558:Electric Stimulation; D005215:Fasting / Q000502:physiology; D007275:Injections, Intravenous; D007328:Insulin / Q000097:blood / Q000502:physiology*; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D009333:Neck / Q000294:innervation; D010276:Parasympatholytics / Q000008:administration & dosage / Q000494:pharmacology; D011863:Radioimmunoassay; D051381:Rats; D017208:Rats, Wistar; D014630:Vagus Nerve / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D010276:Parasympatholytics; D001285:Atropine