title: Serum growth hormone and insulin-like growth factor-1 concentrations in Japanese black cattle with renal tubular dysplasia.
abstract: To elucidate the cause of growth retardation, 14 cattle with renal tubular dysplasia (RTD) were investigated by determining serum growth hormone (GH) and insulin-like growth factor (IGF)-1 concentrations. Compared with 6 healthy cattle, the baseline, maximum, area under the curve and peak amplitude of serum GH concentrations were higher or tended to be higher. Serum IGF-1 concentrations were lower normal or lower in cattle with RTD than in healthy cattle. Serum IGF-1 concentrations correlated significantly with body weight and chest girth, but not with serum GH and creatinine concentrations. Growth retardation in RTD might be associated partially with GH resistance.
authors.affiliation: Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Japan.
authors.forename: Naohito
authors.initials: N
authors.lastname: Nishii
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Ohba
authors.forename: Masaki
authors.initials: M
authors.lastname: Takasu
authors.forename: Kazuo
authors.initials: K
authors.lastname: Katoh
authors.forename: Katsuya
authors.initials: K
authors.lastname: Kitoh
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kitagawa
mesh_terms: D000818:Animals; D049628:Body Size; D001835:Body Weight; D002417:Cattle; D002418:Cattle Diseases / Q000378:metabolism*; D006130:Growth Disorders / Q000097:blood / Q000150:complications / Q000662:veterinary*; D013006:Growth Hormone / Q000097:blood*; D007564:Japan; D007674:Kidney Diseases / Q000097:blood / Q000150:complications / Q000662:veterinary*; D013002:Somatomedins / Q000378:metabolism*
chemical_list: D013002:Somatomedins; D013006:Growth Hormone