[The condition of sympathoadrenal and histaminoreactive systems and the influence of their changes on the peculiarities of a peptic ulcer relapse in patients with myocardial infarction].
The author presents the results of an examination of 106 patients with myocardial infarction (MI) of various severity, who also had a peptic ulcer relapse. Patients with moderate and severe MI in the majority of cases had solitary duodenal ulcers whereas those with extremely severe MI often had multiple ulcers in the body and the cardial part of the stomach, which were bleeding in 43.5% of cases. The pathogenetic basis of the ulcerogenesis was focal microcirculation disorders in the mucosa of the gastroduodenal zone of thrombohemorragic or thromboischemic type. In patients with moderate or severe MI they appeared against the background of hemostatic disturbances typical of the first stage of thrombohemorragic syndrome (hypercoagulation). In extremely severe MI they corresponded to the second stage i.e. partial consumption coagulopathy. In patients with moderate coronary pathology these changes were promoted by the activation of acid-peptic factor, the depression of mucopolysaccharide production, hypo- and hyperkinetic dyskinesis, and in those with extremely severe coronary pathology --the depression of all gastric function except normal acid production. One of the trigger mechanisms of ulcerogenesis could be changes in the activity of sympathoadrenal and histaminereactive systems, which increased in cases of moderate and severe MI and decreases to a certain extent in cases of extremely severe MI.
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D000293:Adolescent; D000328:Adult; D006631:Amine Oxidase (Copper-Containing) / Q000097:blood; D015415:Biomarkers / Q000097:blood / Q000652:urine; D004386:Duodenum / Q000098:blood supply*; D004837:Epinephrine / Q000652:urine*; D005260:Female; D005753:Gastric Mucosa / Q000098:blood supply*; D006487:Hemostasis / Q000502:physiology; D006632:Histamine / Q000097:blood*; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000503:physiopathology; D009203:Myocardial Infarction / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D009638:Norepinephrine / Q000652:urine; D010314:Partial Thromboplastin Time; D010437:Peptic Ulcer / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D012008:Recurrence; D012720:Severity of Illness Index; D019851:Thrombophilia / Q000097:blood / Q000150:complications
D015415:Biomarkers; D006632:Histamine; D006631:Amine Oxidase (Copper-Containing); D009638:Norepinephrine; D004837:Epinephrine