[Clinical evaluation of 23 children with neuroblastoma. The experience of a single institution].
In this retrospective study, we analyse epidemiology, clinical symptoms and therapeutic results in a group of 23 children with neuroblastoma. Half of them were less than 2 years of age; in 19 of 23, the primitive tumour was abdominal; 35% of them were initially metastatic. The overall survival was 83% at 5 years and the event free survival, 75% at 5 years. Pronostic factors are age, extension of the disease at diagnosis, biologic parameters and genetic study of the neuroblast cells (amplification of N-myc oncogen). Our study shows the deleterious effect of bone lesions.
Piette
C
C
Ulg Aspirante FNRS.
Dresse
M F
MF
Forget
P
P
Schmitz
V
V
Demarche
M
M
Erpicum
P
P
Closon
M T
MT
Rutten
I
I
Paulus
P
P
Vivegnis
D
D
Beguin
Y
Y
Jamblin
P
P
Hoyoux
Cl
C
D000008:Abdominal Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009447:Neuroblastoma / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D012189:Retrospective Studies; D013899:Thoracic Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy