title: Repeat prostate biopsies following diagnoses of prostate intraepithelial neoplasia and atypical small gland proliferation.
abstract: OBJECTIVE
  To assess the incidence of diagnosis of high-grade intraepithelial neoplasia or prostate intraepithelial neoplasia (PIN), and atypical small gland proliferation (ASAP) at a uropathology reference center. To assess the indexes and findings on repeat biopsies.
  
  
  METHODS
  Diagnoses of PIN, ASAP or PIN + ASAP established between January 1, 2001 and December 31, 2003 were searched in our database. We studied repeat biopsies performed up to August 31, 2004.
  
  
  RESULTS
  Of 1420 biopsies, ASAP was diagnosed in 26 (1.8%) patients, PIN in 142 (10%) and PIN + ASAP in 40 (2.8%). Repeat biopsies were performed in 98 patients, 16 (61.5%) with ASAP, 53 (37.3%) with PIN and 29 (72.5%) with PIN + ASAP. Carcinoma was diagnosed in 7 cases (43.8%) following a diagnosis of ASAP, 12 (41.4%) of PIN + ASAP and 7 (13.2%) of PIN. The mean interval between repeat biopsies was 299.6 days. There was no difference between groups where cancer was or was not diagnosed on repeat biopsy in relation to age and serum PSA levels.
  
  
  CONCLUSIONS
  Despite explicit recommendations of repeat biopsy on pathology reports and the high incidence of adenocarcinoma on repeat biopsy, re-intervention rates following a diagnosis of PIN, ASAP, PIN + ASAP are low in our setting. The diagnosis that most frequently led to repeat biopsy was PIN + ASAP. Adenocarcinoma was most often diagnosed after the initial diagnosis of ASAP.
authors.affiliation: Laboratory of Surgical and Molecular Pathology, Syrian-Lebanese Hospital, Sao Paulo, SP, Brazil. katiaramos@uol.com.br
authors.forename: Katia R
authors.initials: KR
authors.lastname: Leite
authors.forename: Cristina A
authors.initials: CA
authors.lastname: Mitteldorf
authors.forename: Luiz H
authors.initials: LH
authors.lastname: Camara-Lopes
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D000368:Aged; D001706:Biopsy / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D011230:Precancerous Conditions; D011469:Prostatic Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D019048:Prostatic Intraepithelial Neoplasia / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology