title: [Meta-analysis of postoperative adjuvant chemotherapy for Dukes' B colorectal carcinoma].
abstract: OBJECTIVE
  The necessity of adjuvant chemotherapy after radical surgery for patients with Dukes' B (stage II) colorectal carcinoma remains controversial. This study was to evaluate effect of postoperative adjuvant chemotherapy on survival of Dukes' B patients with meta-analysis.
  
  
  METHODS
  The results of literatures on postoperative adjuvant chemotherapy for Dukes' B patients from 1985 to 2003 were analyzed synthetically.The 5-year survival rates of postoperative adjuvant chemotherapy group and surgery alone group were compared.
  
  
  RESULTS
  Eight published randomized controlled trails were eligible, and had 6 518 patients totally. The 5-year mortality was lower in postoperative adjuvant chemotherapy group than in surgery alone group with odds ratio (OR) of 0.79, and 95% confidence interval (CI) of 0.7-0.9, (P<0.05).
  
  
  CONCLUSIONS
  Postoperative adjuvant chemotherapy could improve 5-year survival rate of Dukes' B patients.
authors.affiliation: Department of Abdominal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P.R.China. zzpan@21cn.com.
authors.forename: Xiang-Bin
authors.initials: XB
authors.lastname: Wan
authors.forename: Zhi-Zhong
authors.initials: ZZ
authors.lastname: Pan
authors.forename: Gong
authors.initials: G
authors.lastname: Chen
authors.forename: Li-Ren
authors.initials: LR
authors.lastname: Li
authors.forename: De-Sen
authors.initials: DS
authors.lastname: Wan
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D006801:Humans; D009367:Neoplasm Staging; D016017:Odds Ratio; D011184:Postoperative Period; D016032:Randomized Controlled Trials as Topic; D015996:Survival Rate
chemical_list: D000970:Antineoplastic Agents