Physiological mechanisms of tumor-cell invasion and migration.
Recent advances in understanding the complex biology of the microenvironment that underlies tumor invasion and migration have revealed novel and promising therapeutic targets. Pharmacological blockade of intra- and extracellular signaling events that regulate migration and survival of multiple cell types may disrupt the host-tumor conspiracy that allows escape from normal developmental regulation.
Geho
David H
DH
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. gehod@mail.nih.gov
Bandle
Russell W
RW
Clair
Timothy
T
Liotta
Lance A
LA
D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D006801:Humans; D009361:Neoplasm Invasiveness / Q000503:physiopathology*; D009369:Neoplasms / Q000473:pathology* / Q000503:physiopathology*