title: Lignans from Schisandra hernyi with DNA cleaving activity and cytotoxic effect on leukemia and Hela cells in vitro.
abstract: The lignans, gomisin G (1), schisantherin A (2), benzoylgomisin Q (3) and isoanwulignan (4) were isolated from the stems of Schisandra henryi. Compound 1 showed moderate DNA strand scission activity and significant cytotoxic effect on leukemia and Hela cells in vitro. Compound 1 represents a new type of DNA strand scission agent.
authors.affiliation: Department of Chemistry, Yunnan Normal University, Kunming, Yunnan 650092, China. ygchen48@hotmail.com
authors.forename: Ye-Gao
authors.initials: YG
authors.lastname: Chen
authors.forename: Zheng-Cai
authors.initials: ZC
authors.lastname: Wu
authors.forename: Shi-Hong
authors.initials: SH
authors.lastname: Gui
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Lv
authors.forename: Xin-Rong
authors.initials: XR
authors.lastname: Liao
authors.forename: Fathi
authors.initials: F
authors.lastname: Halaweish
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004247:DNA / Q000737:chemistry*; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D032141:Schisandra / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; D004247:DNA