title: Olfactory bulb mitral cell dendritic pruning abnormalities in a mouse model of the Fragile-X mental retardation syndrome: further support for FMRP's involvement in dendritic development.
abstract: The Fragile-X mental retardation syndrome is the leading form of inherited mental retardation. Dendritic analysis in a mouse model (FraX) found abnormal pruning in somatosensory cortex. To further characterize dendritic abnormalities and assess their occurrence in other brain regions, we examined mitral cells in FraX mice olfactory bulbs. FraX mice exhibited dendritic abnormalities consistent with somatosensory cortex, suggesting that deficient pruning is found in multiple brain regions.
authors.affiliation: Neuroscience Program, University of Illinois, Urbana, IL 61801, USA.
authors.forename: Roberto
authors.initials: R
authors.lastname: Galvez
authors.forename: Rebecca Lynn
authors.initials: RL
authors.lastname: Smith
authors.forename: William T
authors.initials: WT
authors.lastname: Greenough
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D003712:Dendrites / Q000473:pathology*; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000502:physiology; D051860:Fragile X Messenger Ribonucleoprotein 1; D005600:Fragile X Syndrome / Q000473:pathology* / Q000503:physiopathology; D020868:Gene Silencing / Q000502:physiology; D051379:Mice; D008818:Mice, Neurologic Mutants; D008822:Mice, Transgenic; D009419:Nerve Tissue Proteins / Q000172:deficiency* / Q000235:genetics; D009421:Nervous System Malformations / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D000857:Olfaction Disorders / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D009830:Olfactory Bulb / Q000002:abnormalities* / Q000473:pathology* / Q000503:physiopathology; D009833:Olfactory Pathways / Q000002:abnormalities / Q000473:pathology / Q000503:physiopathology; D016601:RNA-Binding Proteins / Q000235:genetics; D012903:Smell / Q000235:genetics; D013003:Somatosensory Cortex / Q000002:abnormalities / Q000473:pathology / Q000503:physiopathology
chemical_list: D051860:Fragile X Messenger Ribonucleoprotein 1; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins; C497684:Fmr1 protein, mouse