[Genetic and immunological basis for ulcerative colitis].
Ulcerative colitis is a chronic inflammatory disease of the rectum and colon. Results from many studies in people and animals of intestinal inflammation suggest that ulcerative colitis results from environmental factors triggering a loss of tolerance for normal intestinal flora in genetically susceptible individuals. Although progress has been made in the overall management of the disease, there are few clinical data on biological agents in contrast to Crohn' s disease. Here, we discuss the genetic and immunological basis of ulcerative colitis including the recent findings.
Tsuchiya
Kiichiro
K
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University.
Watanabe
Mamoru
M
D003093:Colitis, Ulcerative / Q000235:genetics* / Q000276:immunology*; D016207:Cytokines / Q000502:physiology; D019450:Genes, MDR / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D015395:Histocompatibility Antigens Class I; D006801:Humans; D018836:Inflammation Mediators; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics; D008213:Lymphocyte Activation; D055263:Mucin-3; D009077:Mucins / Q000235:genetics; D009154:Mutation; D052002:NF-kappa B p50 Subunit; D011506:Proteins / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology; D014157:Transcription Factors / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D016207:Cytokines; D015395:Histocompatibility Antigens Class I; D018836:Inflammation Mediators; C099187:MHC class I-related chain A; D055263:Mucin-3; D009077:Mucins; D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human; D011506:Proteins; D014157:Transcription Factors; D014409:Tumor Necrosis Factor-alpha; D018799:Intercellular Adhesion Molecule-1