title: Cochlear function in mice following inhalation of brevetoxin-3.
abstract: Brevetoxin-3 was shown previously to adversely affect central auditory function in goldfish. The present study evaluated the effects of exposure to this agent on cochlear function in mice using the 2f(1)-f(2) distortion-product otoacoustic emission (DPOAE). Towards this end, inbred CBA/CaJ mice were exposed to a relatively high concentration of brevetoxin-3 (approximately=400 microg/m(3)) by nose-only inhalation for a 2-h period. Further, a subset of these mice received a second exposure a day later that lasted for an additional 4 h. Mice exposed only once for 2 h did not exhibit any notable cochlear effects. Similarly, mice exposed two times, for a cumulative dose of 6 h, exhibited essentially no change in DPOAE levels.
authors.affiliation: Lovelace Respiratory Research Institute, Albuquerque, NM, USA.
authors.forename: Janet M
authors.initials: JM
authors.lastname: Benson
authors.forename: Barden B
authors.initials: BB
authors.lastname: Stagner
authors.forename: Glen K
authors.initials: GK
authors.lastname: Martin
authors.forename: Melissa
authors.initials: M
authors.lastname: Friedman
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Durr
authors.forename: Andrea
authors.initials: A
authors.lastname: Gomez
authors.forename: Jacob
authors.initials: J
authors.lastname: McDonald
authors.forename: Lora E
authors.initials: LE
authors.lastname: Fleming
authors.forename: Lorraine C
authors.initials: LC
authors.lastname: Backer
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Baden
authors.forename: Andrea
authors.initials: A
authors.lastname: Bourdelais
authors.forename: Jerome
authors.initials: J
authors.lastname: Naar
authors.forename: Brenda L
authors.initials: BL
authors.lastname: Lonsbury-Martin
mesh_terms: D000161:Acoustic Stimulation; D000280:Administration, Inhalation; D000818:Animals; D003051:Cochlea / Q000187:drug effects*; D005260:Female; D018072:Hair Cells, Auditory, Outer / Q000187:drug effects*; D006309:Hearing / Q000187:drug effects*; D019570:Inhalation Exposure; D008387:Marine Toxins / Q000008:administration & dosage / Q000633:toxicity*; D051379:Mice; D008808:Mice, Inbred CBA; D035964:Oxocins / Q000008:administration & dosage / Q000633:toxicity*; D010469:Perceptual Distortion; D000095702:Polyether Toxins
chemical_list: D008387:Marine Toxins; D035964:Oxocins; C502852:brevetoxin 3, Karenia brevis; D000095702:Polyether Toxins