title: [Central control of bone metabolism].
abstract: Leptin, a well-known adipokine regulating energy metabolism, inhibits bone formation via sympathetic nervous system. Recently, it was reported that adrenergic beta(2) receptor-deficient mice have high bone mass due to increased bone formation and decreased bone resorption. In addition, cocaine- and amphetamine-regulated transcript, an anorexigenic neuropeptide whose expression is regulated by leptin, has been shown to inhibit bone resorption. Thus, leptin regulates not only bone formation but bone resorption centrally.
authors.affiliation: Department of Orthopedics, Center of Excellence Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University.
authors.forename: Shu
authors.initials: S
authors.lastname: Takeda
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000503:physiopathology; D001842:Bone and Bones / Q000378:metabolism*; D001921:Brain / Q000502:physiology*; D006801:Humans; D020738:Leptin / Q000502:physiology; D051379:Mice; D013564:Sympathetic Nervous System / Q000502:physiology
chemical_list: D020738:Leptin