title: Zebrafish hairy/enhancer of split protein links FGF signaling to cyclic gene expression in the periodic segmentation of somites.
abstract: Notch and fibroblast growth factor (FGF) signaling pathways have been implicated in the establishment of proper periodicity of vertebrate somites. Here, we show evidence that a Hes6-related hairy/Enhancer of split-related gene, her13.2, links FGF signaling to the Notch-regulated oscillation machinery in zebrafish. Expression of her13.2 is induced by FGF-soaked beads and decreased by an FGF signaling inhibitor. her13.2 is required for periodic repression of the Notch-regulated genes her1 and her7, and for proper somite segmentation. Furthermore, Her13.2 augments autorepression of her1 in association with Her1 protein. Therefore, FGF signaling appears to maintain the oscillation machinery by supplying a binding partner, Her13.2, for Her1.
authors.affiliation: Okazaki Institute for Integrative Biosciences, National Institutes of Natural Sciences, Okazaki, Aichi 444-8787, Japan.
authors.forename: Akinori
authors.initials: A
authors.lastname: Kawamura
authors.forename: Sumito
authors.initials: S
authors.lastname: Koshida
authors.forename: Hiroko
authors.initials: H
authors.lastname: Hijikata
authors.forename: Takuya
authors.initials: T
authors.lastname: Sakaguchi
authors.forename: Hisato
authors.initials: H
authors.lastname: Kondoh
authors.forename: Shinji
authors.initials: S
authors.lastname: Takada
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D019521:Body Patterning / Q000235:genetics / Q000502:physiology*; D005346:Fibroblast Growth Factors / Q000378:metabolism / Q000494:pharmacology; D018507:Gene Expression Regulation, Developmental / Q000235:genetics / Q000502:physiology*; D012097:Repressor Proteins; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D019170:Somites / Q000378:metabolism*; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics; D029961:Zebrafish Proteins / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D005346:Fibroblast Growth Factors; D012097:Repressor Proteins; D014157:Transcription Factors; D029961:Zebrafish Proteins; C460099:HER7 protein, zebrafish; C000608283:Hes6 protein, zebrafish; C491619:her1 protein, zebrafish