Floating-Harbor syndrome complicated by tethered cord: a new association and potential contribution from growth hormone therapy.
Floating-Harbor syndrome is a rare syndrome with short stature, severely delayed bone age, typical facies and delay in expressive speech. Structural malformations are uncommon, and tethered cord or other forms of spinal dysraphism have not previously been reported. We report on a case of Floating-Harbor syndrome, complicated by tethered cord and discuss the possibility that growth hormone therapy may contribute to the development of symptoms of this malformation.
Wiltshire
Esko
E
Department of Paediatrics and Child Health, Wellington School of Medicine and Health Sciences, Wellington South, New Zealand. esko@wnmeds.ac.nz
Wickremesekera
Agadha
A
Dixon
Joanne
J
D000015:Abnormalities, Multiple / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D001848:Bone Diseases, Developmental / Q000473:pathology*; D002648:Child; D005145:Face / Q000002:abnormalities*; D005260:Female; D006130:Growth Disorders / Q000473:pathology*; D019382:Human Growth Hormone / Q000627:therapeutic use; D006801:Humans; D007621:Karyotyping; D007805:Language Development Disorders / Q000473:pathology; D016135:Spinal Dysraphism / Q000473:pathology*; D013577:Syndrome; D016896:Treatment Outcome
D019382:Human Growth Hormone