Total and regional body composition and energy expenditure in multiple symmetric lipomatosis.
OBJECTIVE
The aim of the present study was to investigate possible alterations in body composition and resting energy expenditure (REE) in type 1 multiple symmetric lipomatosis (MSL).


METHODS
Thirteen men aged from 40 to 78 years affected by type I MSL were compared with 13 healthy control subjects. Fat mass (FM) and fat-free mass (FFM) were determined by DEXA using both standard analysis and specifically for the lipomatous region. REE was measured by indirect calorimetry.


RESULTS
FM was higher in MSL subjects at proximal arm level, but significantly lower at distal leg level than in controls (left 1.63+/-0.55 vs. 2.26+/-0.49 kg, P<0.05; right 1.63+/-0.53 vs. 2.40+/-0.54 kg, P<0.01). Arm FFM was similar in the two groups, while distal leg FFM was significantly lower in MSL cases (left: 7.8+/-1.3 vs. 8.7+/-0.8 kg, P<0.05; right: 8.0+/-1.5 vs. 9.2+/-0.9 kg, P<0.05). FFM strongly correlated with REE (r:0.86;P<0.001). REE, expressed as an absolute value and adjusted for FFM (1830+/-215 vs. 1675+/-120 kcal, P<0.05) was higher in MSL patients.


CONCLUSIONS
In conclusion, MSL patients had a marked FFM and FM atrophy in the lower segments of the legs and an altered energy expenditure (hypermetabolism).
Coin
Alessandra
A
Department of Medical and Surgical Sciences, Geriatrics Division, University of Padova, Via Giustiniani, 2,35128 Padova, Italy. alessandra.coin@unipd.it
Sergi
Giuseppe
G
Enzi
Giuliano
G
Busetto
Luca
L
Pigozzo
Sabrina
S
Lupoli
Lucia
L
Sträter
Dinah
D
Peruzza
Silvia
S
Inelmen
Emine Meral
EM
D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D001481:Basal Metabolism; D001823:Body Composition; D002153:Calorimetry, Indirect; D004734:Energy Metabolism; D006801:Humans; D008069:Lipomatosis, Multiple Symmetrical / Q000378:metabolism*; D008297:Male; D008875:Middle Aged