title: Elevated levels of soluble interleukin-2 receptor in serum of patients with hematological or non-hematological malignancies.
abstract: We measured the levels of soluble interleukin-2 receptor (sIL-2R) in the serum of 53 patients with hematological malignancies (14 with acute leukemia, 10 myeloproliferative disorders, 21 non-Hodgkin's lymphoma and 8 multiple myeloma), 40 with non-hematological solid malignancies (24 with lung cancer, 11 digestive system cancer and 5 other cancers) and 95 healthy subjects as a control using an enzyme-linked immunosorbent assay. Both hematological and non-hematological neoplasms showed significantly higher sIL-2R levels than normal subjects (p<0.01). However, compared to solid malignancies, hematological neoplasms displayed a wide range of sIL-2R levels and extremely elevated values of sIL-2R were seen in certain cases. These results seem to suggest that sIL-2R levels may serve as one of non-invasive markers of differential diagnosis for patients with bulky mass lesions between hematological and solid malignancy.
authors.affiliation: Second Department of Internal Medicine, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan. k2nakase@clin.medic.mie-u.ac.jp
authors.forename: Kazunori
authors.initials: K
authors.lastname: Nakase
authors.forename: Kota
authors.initials: K
authors.lastname: Tsuji
authors.forename: Sigehisa
authors.initials: S
authors.lastname: Tamaki
authors.forename: Motoaki
authors.initials: M
authors.lastname: Tanigawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ikeda
authors.forename: Eiki
authors.initials: E
authors.lastname: Miyanishi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shiku
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D019337:Hematologic Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D015375:Receptors, Interleukin-2