[Clinical observation on effect of Chinese herbs in adjusting hypoestrogenemia status by clomiphene to promote ovulation].
OBJECTIVE
To explore the effect of Yijing Huoxue Cuyun Decoction (YHCD) in adjusting hypoestrogenemic response induced by clomiphene.


METHODS
Infertile patients caused by ovulation disturbance were randomly divided into 2 groups. The 60 patients in the observed group were treated with clomiphine plus YHCD, and the 58 patients in the control group were given clomiphine plus estradiol valerate.


RESULTS
By scoring on the cervical relaxation and improvement of cervical mucus, 38 patients (63.3%) in the observed group had Insler score of more than 8 points, while that in the control group was only 25 (43.1%), comparison between the two groups showed significant difference (P < 0.05). The endometrium thickening in the observed group was 0.98 +/- 0.19 cm, significantly different to that in the control group (0.85 +/- 0.21 cm, P < 0.01). Twenty-five patients in the observed group (41.7%), and fourteen patients in the control group (24.1%), respectively got pregnancy, the pregnant rate in the former was obviously higher than that in the latter (P < 0.05).


CONCLUSIONS
YHCD can ameliorate hypoestrinemia induced by clomiphene and increase the pregnant rate in patients.
Ma
Shu-Xiu
SX
Institute of Infertility, Traditional Chinese Medicine Hospital of Ju County, Shandong. shuxium@yahoo.com.cn
Yin
De-E
DE
Zhu
Yu-Lian
YL
D000328:Adult; D002996:Clomiphene / Q000009:adverse effects / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004967:Estrogens / Q000097:blood* / Q000172:deficiency; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*; D010060:Ovulation / Q000187:drug effects; D010062:Ovulation Induction; D008517:Phytotherapy
D004365:Drugs, Chinese Herbal; D004967:Estrogens; D002996:Clomiphene