NAT2 fast acetylator genotype is associated with an increased risk of lung cancer among never-smoking women in Taiwan.
The correlation between cooking oil fumes, containing relatively higher amounts of heterocyclic amines, and female lung cancer has been revealed. The association of genetic polymorphisms of CYP1A2 and NAT2, two major enzymes responsible for the metabolism of heterocyclic amines, with lung cancer has been investigated with inconclusive results. In this study targeted on never-smoking population with 162 lung cancer patients and 208 non-cancer controls, while the distributions of CYP1A2 phenotypes in lung cancer patients were comparable to that in controls, NAT2 fast acetylators had an OR of 2.44 (95% CI 1.40-4.23, P=0.002) and 2.56 (95% CI 1.37-4.80, P=0.003) for lung cancer in overall and female cases, respectively, but not in males. These results suggested never-smoking females with NAT2 fast acetylator were more prone to lung cancer and reflected the possibility that exposure to heterocyclic amines may contribute to the female lung cancer development in Taiwan.
Chiou
Hui-Ling
HL
School of Medical Technology, Chung Shan Medical University, Taichung, Taiwan, ROC.
Wu
Ming-Fang
MF
Chien
Wen-Pin
WP
Cheng
Ya-Wen
YW
Wong
Ruey-Hong
RH
Chen
Chin-Yi
CY
Lin
Torng-Sen
TS
Lee
Huei
H
D000328:Adult; D000368:Aged; D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D019388:Cytochrome P-450 CYP1A2; D005260:Female; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D012306:Risk; D012727:Sex Characteristics; D012907:Smoking / Q000009:adverse effects
D019388:Cytochrome P-450 CYP1A2; D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human