title: ETV6 gene rearrangements in invasive breast carcinoma.
abstract: The ETV6/TEL gene encodes a transcription factor frequently rearranged in several types of cancer. We looked for ETV6 rearrangements in invasive breast cancer using fluorescence in situ hybridization (FISH) of BAC probes on sections of tissue microarrays containing 632 tumor samples. Of these samples, signal of sufficient quality for screening by FISH was obtained for 356. Five cases (one lobular, one nontypical secretory, one mixed, and two ductal carcinomas) showed ETV6 rearrangement.
authors.affiliation: Marseille Cancer Institute, Laboratory of Molecular Oncology, Institut Paoli-Calmettes and UMR599 Inserm, Marseille, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Letessier
authors.forename: Christophe
authors.initials: C
authors.lastname: Ginestier
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Charafe-Jauffret
authors.forename: Nathalie
authors.initials: N
authors.lastname: Cervera
authors.forename: José
authors.initials: J
authors.lastname: Adélaïde
authors.forename: Véronique
authors.initials: V
authors.lastname: Gelsi-Boyer
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Ahomadegbe
authors.forename: Jean
authors.initials: J
authors.lastname: Benard
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Jacquemier
authors.forename: Daniel
authors.initials: D
authors.lastname: Birnbaum
authors.forename: Max
authors.initials: M
authors.lastname: Chaffanet
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019677:Artificial Gene Fusion; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002503:Centromere / Q000235:genetics; D002874:Chromosome Mapping; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009687:Nuclear Proteins / Q000235:genetics*; D050783:Proto-Oncogene Proteins c-ets; D012097:Repressor Proteins / Q000235:genetics*; D016615:Telomere / Q000235:genetics; D000097764:ETS Translocation Variant 6 Protein
chemical_list: D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D050783:Proto-Oncogene Proteins c-ets; D012097:Repressor Proteins; D000097764:ETS Translocation Variant 6 Protein