Identification of fatty acid binding proteins as markers associated with the initiation and/or progression of renal cell carcinoma.
Renal cell carcinoma (RCC) representing the most common neoplasia of the kidney in Western countries is a histologic diverse disease with an often unpredictable course. The prognosis of RCC is worsened with the onset of metastasis, and the therapies currently available are of limited success for the treatment of metastatic RCC. Although gene expression analyses and other methods are promising tools clarifying and standardizing the pathological classification of RCC, novel innovative molecular markers for the diagnosis, prognosis, and for the monitoring of this disease during therapy as well as potential therapeutic targets are urgently needed. Using proteome-based strategies, a number of RCC-associated markers either over-expressed or down-regulated in tumor lesions in comparison to the normal epithelium have been identified which have been implicated in tumorigenesis, but never linked to the initiation and/or progression of RCC. These include members of the fatty acid binding protein family, which have the potential to serve as diagnostic or prognostic markers for the screening of RCC patients.
Seliger
Barbara
B
Johannes Gutenberg University Mainz, 3rd Department of Internal Medicine, Mainz, Germany. barbara.seliger@medizin.uni-halle.de
Lichtenfels
Rudolf
R
Atkins
Derek
D
Bukur
Jürgen
J
Halder
Thomas
T
Kersten
Michael
M
Harder
Alois
A
Ackermann
Angelika
A
Malenica
Barbara
B
Brenner
Walburgis
W
Zobawa
Monica
M
Lottspeich
Friedrich
F
D014408:Biomarkers, Tumor / Q000032:analysis / Q000302:isolation & purification; D002292:Carcinoma, Renal Cell / Q000145:classification / Q000473:pathology / Q000503:physiopathology*; D002352:Carrier Proteins / Q000032:analysis* / Q000235:genetics / Q000302:isolation & purification; D045744:Cell Line, Tumor; D017931:DNA Primers; D018450:Disease Progression; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods; D050556:Fatty Acid-Binding Proteins; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney; D007680:Kidney Neoplasms / Q000145:classification / Q000473:pathology / Q000503:physiopathology*; D011379:Prognosis; D012016:Reference Values; D020133:Reverse Transcriptase Polymerase Chain Reaction; D019459:Urothelium / Q000737:chemistry / Q000378:metabolism
D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D017931:DNA Primers; D050556:Fatty Acid-Binding Proteins