[Color reaction of chlorhexidine and proguanil with hypobromite].
Colour reaction of chlorhexidine and proguanil with hypobromite The antimalarial agent proguanil reacts with hypobromite to yield the red coloured (E)-3-[(4-chlorophenyl)imino]-N-isopropyl-3H-1,2,4-triazol-5-amine (6B). The structure of 6B was proven by X-ray. The red colour obtained by the test for the disinfectant chlorhexidinedihydrochloride Ph. Eur. with hypobromite is probably attributable to a corresponding chromophore.
Görlitzer
K
K
Institut für Pharmazeutische Chemie1 der Technischen Universität Braunschweig, Germany. k.goerlitzer@tu-bs.de
Huth
S
S
Jones
P G
PG
D000962:Antimalarials / Q000737:chemistry*; D001959:Bromates / Q000737:chemistry*; D002710:Chlorhexidine / Q000737:chemistry*; D003116:Color; D018360:Crystallography, X-Ray; D004202:Disinfectants / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D002727:Proguanil / Q000737:chemistry*
D000962:Antimalarials; D001959:Bromates; D004202:Disinfectants; C027664:hypobromous acid; D002710:Chlorhexidine; D002727:Proguanil