Oligonucleotides and polyribonucleotides: a review of antiviral activity.
Current antiviral therapies are insufficient for treating emerging, re-emerging and established viral diseases. In an effort to find new therapeutics, oligo- and polyribonucleotides are being studied for their antiviral capabilities. Studies have shown that uniquely modified single- and double-stranded nucleic acid constructs are effective in inhibiting viral proliferation by various mechanisms. This review gives a brief history and highlights the development of oligo- and polyribonucleotides as antiviral agents primarily in the fields of interferon induction, mRNA complementation and reverse transcriptase inhibition.
Markosian
Michael
M
Westminster College, Salt Lake City, UT, USA.
Hyde
Robyn M
RM
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D009841:Oligonucleotides / Q000494:pharmacology*; D011131:Polyribonucleotides / Q000494:pharmacology*; D014777:Virus Diseases / Q000188:drug therapy
D000998:Antiviral Agents; D009841:Oligonucleotides; D011131:Polyribonucleotides