title: The rhodium catalyzed three-component reaction of diazoacetates, titanium(IV) alkoxides and aldehydes.
abstract: The rhodium(II)-catalyzed three-component reaction of diazoacetates, titanium alkoxides and aldehydes is shown to give alpha-alkoxyl-beta-hydroxyl acid derivatives; the novel C-C bond formation reaction is proposed to occur through oxonium ylides derived from diazo compounds and titanium alkoxides, and followed by intermolecular trapping by aldehydes.
authors.affiliation: Key Laboratory for Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China.
authors.forename: Chong-Dao
authors.initials: CD
authors.lastname: Lu
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Chen
authors.forename: Wen-Hao
authors.initials: WH
authors.lastname: Hu
authors.forename: Ai-Qiao
authors.initials: AQ
authors.lastname: Mi
mesh_terms: D000085:Acetates / Q000138:chemical synthesis / Q000737:chemistry*; D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry*; D001391:Azo Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D008968:Molecular Conformation; D009942:Organometallic Compounds; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism; D014025:Titanium / Q000737:chemistry*
chemical_list: D000085:Acetates; D000447:Aldehydes; D001391:Azo Compounds; D009942:Organometallic Compounds; C102815:titanium isopropoxide; D014025:Titanium; D012238:Rhodium