Influence of the Ginkgo extract EGb 761 on rat liver cytochrome P450 and steroid metabolism and excretion in rats and man.
Extracts from leaves of Ginkgo biloba L. are among the most used herbal medicinal products worldwide. Based on in-vitro tests and studies in rats, concern has been expressed that intake of Ginkgo extracts may affect hepatic metabolism of xenobiotics and cause drug interactions, although no evidence for modulation of cytochrome P450 (CYP450) enzyme activity was obtained in human trials. Because of these contradictory findings, we investigated the effects of the standardised extract EGb 761 on hepatic CYP450 in rats. EGb 761 (100 mg kg-1 daily, p.o., for 4 days) strongly increased liver CYP450 content and altered the ex-vivo biotransformation of androstendione, as well as metabolism of endogenous steroids. However, in human subjects no effect on the urinary steroid profile was observed after intake of EGb 761 for 28 days (240 mg daily). These results indicate that the effects of EGb 761 on drug metabolising enzymes are specific for rats and may not be extrapolated to man.
Chatterjee
Shyam S
SS
Dr Willmar Schwabe Pharmaceuticals, Willmar-Schwabe-Str. 4, 76227 Karlsruhe, Germany.
Doelman
Cees J A
CJ
Nöldner
Michael
M
Biber
Anton
A
Koch
Egon
E
D000284:Administration, Oral; D000368:Aged; D000735:Androstenedione / Q000493:pharmacokinetics; D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005260:Female; D020441:Ginkgo biloba; D006801:Humans; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008875:Middle Aged; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013256:Steroids / Q000378:metabolism / Q000652:urine; D000096983:Ginkgo Extract
D000735:Androstenedione; D003577:Cytochrome P-450 Enzyme System; D010936:Plant Extracts; D013256:Steroids; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract