Serial ligand catalysis: a highly selective allylic C-H oxidation.
We are reporting a mild, chemo-, and highly regioselective Pd(II)-catalyzed allylic oxidation of alpha-olefins to furnish branched allylic esters that proceeds via a novel serial ligand catalysis mechanism in which two different ligands (i.e., vinyl sulfoxide 2 and BQ) interact sequentially with the metal to promote distinct steps of the catalytic cycle (i.e., C-H cleavage and pi-allyl functionalization, respectively).
Chen
Mark S
MS
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Narayanasamy
Prabagaran
P
Labenz
Nathan A
NA
White
M Christina
MC