title: Cholestatic liver injury after glimepiride therapy.
abstract: Drug induced hepatotoxicity has been reported infrequently with sulfonylureas. For glimepiride, a second-generation sulfonylurea there is no report of hepatotoxicity in English literature. A patient with non-insulin-dependent diabetes mellitus who developed cholestatic liver injury soon after initiation of glimepiride therapy is presented. Complete work-up disclosed no other cause for hepatotoxicity including negative serological results for viral hepatitis. Liver biopsy was consistent with drug-induced cholestasis. The patient recovered 50 days after stopping glimepiride with no further recurrences.
authors.affiliation: Hepatology Division, 4th Academic Department of Internal Medicine, Attikon University General Hospital, 7 Orfeos Street, Palaio Faliro, 17564 Athens, Greece. hgiama@ath.forthnet.gr
authors.forename: Athina
authors.initials: A
authors.lastname: Chounta
authors.forename: Spyros
authors.initials: S
authors.lastname: Zouridakis
authors.forename: Christos
authors.initials: C
authors.lastname: Ellinas
authors.forename: Sotirios
authors.initials: S
authors.lastname: Tsiodras
authors.forename: Christina
authors.initials: C
authors.lastname: Zoumpouli
authors.forename: Stylianos
authors.initials: S
authors.lastname: Kopanakis
authors.forename: Helen
authors.initials: H
authors.lastname: Giamarellou
mesh_terms: D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D002779:Cholestasis / Q000139:chemically induced* / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D008297:Male; D009336:Necrosis; D013453:Sulfonylurea Compounds / Q000009:adverse effects*
chemical_list: D007004:Hypoglycemic Agents; D013453:Sulfonylurea Compounds; C057619:glimepiride