title: [Protective effects of losartan against myocardial ischemic reperfusion in intact canine].
abstract: OBJECTIVE
  To evaluate the protective effect of losartan, an angiotensin II type 1 (AT1) receptor antagonist, against myocardial ischemic reperfusion in intact canine.
  
  
  METHODS
  Sixteen dogs were divided into model group(n=8) with left anterior descending coronary artery occlusion for 30 min followed by reperfusion for 30 min and losartan group (n=8) with 5 mg/(kg x d) intragastric losartan administration for 2 weeks before the ischemic-reperfusion model establishment. Monophasic action potential recording technique was employed to observe the incidence of early after depolarization (EAD) and reperfusion arrhythmias.
  
  
  RESULTS
  In the model group, 5 dogs (62.5%) developed EAD and reperfusion arrhythmia while 3 (37.5%) developed the symptoms in losartan group, showing significant difference between the two groups (P<0.05). No ventricular tachycardia or ventricular fibrillation was observed in losartan group (P<0.01).
  
  
  CONCLUSIONS
  Losartan can suppress the occurrence of EAD during reperfusion following myocardial ischemia to reduce the incidence of reperfusion arrhythmias, suggesting its protective effect against myocardial ischemic injury.
authors.affiliation: Department of Cardiology, People's Hospital of Taiping, Dongguang 523900, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Yang
authors.forename: Zhi-cheng
authors.initials: ZC
authors.lastname: Huo
authors.forename: Jian
authors.initials: J
authors.lastname: Peng
authors.forename: Man-ying
authors.initials: MY
authors.lastname: Jia
authors.forename: Zheng
authors.initials: Z
authors.lastname: Huang
authors.forename: Zhi-ming
authors.initials: ZM
authors.lastname: Wang
authors.forename: Yu-lan
authors.initials: YL
authors.lastname: Chen
mesh_terms: D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D004285:Dogs; D004594:Electrophysiology; D005260:Female; D019808:Losartan / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy*; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D019808:Losartan