title: [Experimental study of apoptosis and Fas antigen expression in craniocerebral trauma].
abstract: OBJECTIVE
  To evaluate the change in Fas antigen expression and apoptosis of neurons, to provide an experimental evidence of loss of neurons in craniocerebral injury, and to provide experimental evidence for clarifying multi-approach of the lost neuron after damage.
  
  
  METHODS
  Brain impact injury was reproduced in SD rat with a free falling impacting device. Using immunohistochemistry method the Fas protein expression was assessed and apoptotic cells were detected with electron microscopy.
  
  
  RESULTS
  Apoptotic cells were found near the contused area, and Fas-positive cells appeared around the injured and hippocampus areas at about 4 hours, peaked at 24 hours after injury and then reduced in number.
  
  
  CONCLUSIONS
  Apoptosis and necrosis are two forms of cell death in brain tissue following experimental brain contusion. Moreover, the results imply that the Fas-FasL pathway plays a pivotal role in the pathophysiology of post-traumatic neuronal apoptosis.
authors.affiliation: Department of Neurosurgery, Baogang Hospital, Shanghai Second Medical University, Shanghai 201900, China.
authors.forename: Yan-bin
authors.initials: YB
authors.lastname: Ma
authors.forename: Zhi-an
authors.initials: ZA
authors.lastname: Zhu
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Jian-hua
authors.initials: JH
authors.lastname: Qiu
authors.forename: Bo
authors.initials: B
authors.lastname: Xiao
authors.forename: Dong-fu
authors.initials: DF
authors.lastname: Feng
mesh_terms: D000818:Animals; D017209:Apoptosis; D006259:Craniocerebral Trauma / Q000378:metabolism / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D009474:Neurons / Q000378:metabolism / Q000473:pathology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D019014:fas Receptor / Q000235:genetics / Q000378:metabolism*
chemical_list: D019014:fas Receptor