title: [Cushing's syndrome and adrenal adenoma. Two surprising associations].
abstract: BACKGROUND
  Cushing's syndrome has a very low incidence (1-10 cases/million/year), and familial cases are even more rare. We report on two situations involving different causes of Cushing's syndrome.
  
  
  METHODS
  In the first case, we describe the case of a patient with an adrenal adenoma 20 years before the occurrence of Cushing's disease related to the pineal gland. In the second case, two members of the same family were diagnosed almost simultaneously with adrenal cortical adenoma (mother) and Cushing's disease (daughter).
  
  
  CONCLUSIONS
  These cases lead us to consider the known causes of familial Cushing's syndrome, which were not found here.
authors.affiliation: Service des maladies endocriniennes et métaboliques, Hôpital Cochin, Paris.
authors.forename: S
authors.initials: S
authors.lastname: Ouzounian
authors.forename: F
authors.initials: F
authors.lastname: Tissier
authors.forename: H
authors.initials: H
authors.lastname: Gouya
authors.forename: M
authors.initials: M
authors.lastname: Kujas
authors.forename: A
authors.initials: A
authors.lastname: Louvel
authors.forename: P
authors.initials: P
authors.lastname: Legmann
authors.forename: X
authors.initials: X
authors.lastname: Bertagna
mesh_terms: D000236:Adenoma / Q000150:complications*; D000310:Adrenal Gland Neoplasms / Q000150:complications*; D000328:Adult; D003480:Cushing Syndrome / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D013997:Time Factors