[Defensin NP-1 in restoration of the injured nerve trunk functions].
The effect of Defensin NP-1 on early phase of injured sciatic nerve regeneration was studied in rats. Using the technique of AP compound recording performed within 21 days after the nerve trunk cutting with subsequent microsurgical nerve suture, the rate of fibres growth was shown to increase by 30% following Defensin treatment: the distance to which the nerve impulse conductivity through injured nerve fibres was restored has extended from 7.22 +/- 1.2 mm (control) to 10.5 +/- 0.8 mm (Defensin treatment) from the suture site (p < 0.05). Moreover, the conducting capacity of the regenerating nerve fibres has risen by 20% as compared with control values. The findings suggest a positive effect of Defensin on restoration of injured peripheral nerve in rats.
Nozdrachev
A D
AD
Kolosova
L I
LI
Moiseeva
A B
AB
Riabchikova
O V
OV
D000200:Action Potentials; D000818:Animals; D004558:Electric Stimulation; D008297:Male; D009412:Nerve Fibers / Q000187:drug effects / Q000502:physiology*; D009416:Nerve Regeneration / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000187:drug effects / Q000502:physiology*; D023084:alpha-Defensins / Q000494:pharmacology / Q000502:physiology*
D023084:alpha-Defensins; C406564:defensin NP-1