title: Synthesis and antimicrobial properties of 3-sulfonyl-1,2,3,4-tetrahydropyrimido [4,5-d] pyrimidines.
abstract: The paper presents the synthesis of sulfonyl tetrahydropyrimido[4,5-d]pyrimidine derivatives as well as the antimicrobial activity of the obtained compounds. The investigations showed that the obtained sulfonyl derivatives of pyrimido[4,5-d]pyrimidines and especially the compounds with free amino group reveal interesting antibacterial and antifungal activity.
authors.affiliation: Department of Organic Chemistry, Medical Academy, Wrocław, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Cieplik
authors.forename: Janusz
authors.initials: J
authors.lastname: Pluta
authors.forename: Olaf
authors.initials: O
authors.lastname: Gubrynowicz
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005658:Fungi / Q000187:drug effects; D007202:Indicators and Reagents; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013450:Sulfones / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D007202:Indicators and Reagents; D011743:Pyrimidines; D013450:Sulfones