title: Image-guided cutting-edge-needle biopsy of peripheral lymph nodes and superficial masses for the diagnosis of lymphoma.
abstract: OBJECTIVE
  To evaluate the diagnostic efficacy of image-guided cutting-edge-needle biopsy of peripheral lymph nodes and superficial masses for the diagnosis of lymphoma, for which many still advocate open surgical resection.
  
  
  METHODS
  A retrospective analysis was performed of the medical records of 114 lymphoma patients who presented with peripheral lymphadenopathy and superficial masses and who underwent diagnostic image-guided biopsy. There were 69 non-Hodgkin lymphoma patients, 38 Hodgkin lymphoma patients, and 7 patients who were evaluated for histologic transformation of CLL or high grade lymphoma.
  
  
  RESULTS
  Image-guided needle biopsy was diagnostic in 96/114 (84.2%) patients. The procedure was diagnostic in 59/69 (85.5%) of NHL patients and in 30/38 of Hodgkin disease patients (79%). Diagnoses were achieved for all 7 cases where histologic transformation was suspected.
  
  
  CONCLUSIONS
  Percutaneous image-guided needle biopsy is a safe and reliable procedure with a high diagnostic yield. It can be used as a first step in patients suspected of having lymphoma presenting with enlarged peripheral lymph nodes and superficial masses.
authors.affiliation: Department of Radiology, Hadassah University Hospital, Jerusalem, Israel. mirisl@hadassah.org.il
authors.forename: Miriam
authors.initials: M
authors.lastname: Sklair-Levy
authors.forename: Gail
authors.initials: G
authors.lastname: Amir
authors.forename: Galia
authors.initials: G
authors.lastname: Spectre
authors.forename: Pinhas
authors.initials: P
authors.lastname: Lebensart
authors.forename: Yakov
authors.initials: Y
authors.lastname: Applbaum
authors.forename: Ronit
authors.initials: R
authors.lastname: Agid
authors.forename: Sivan
authors.initials: S
authors.lastname: Lieberman
authors.forename: Dina
authors.initials: D
authors.lastname: Ben-Yehuda
authors.forename: Yoav
authors.initials: Y
authors.lastname: Sherman
authors.forename: Eugine
authors.initials: E
authors.lastname: Libson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000379:methods; D002648:Child; D002675:Child, Preschool; D005260:Female; D006689:Hodgkin Disease / Q000175:diagnosis*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies