Association between polymorphisms of the GPX1 gene and second primary tumours after index squamous cell cancer of the head and neck.
We investigated the association between genetic polymorphisms in GPX1 gene amongst patients who had index squamous cell carcinoma (SCCHN) and a second primary tumour (SPT) after a primary SCCHN in a case-control study. GPX1 genotypes were determined for 61 patients with SPT and for 259 control subjects by a PCR technique using a fluorescent-labelled primer. Analysis was by an ABI automated fluorescent sequencer. The associations between specific genotypes and the development of SPT were examined by logistic regression. A significant difference was found between the control group and the SPT cases in allele frequencies of GPX1 ALA( *)6 and ALA( *)7 (p(trend)=0.04). These results suggest that polymorphisms in the GPX1 gene may be a marker for SPT development and further studies are indicated.
Jefferies
S
S
Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.
Kote-Jarai
Z
Z
Goldgar
D
D
Houlston
R
R
Frazer-Williams
M-J
MJ
A'Hern
R
R
Eeles
R
R
Henk
J
J
Gore
M
M
Rhys-Evans
P
P
Archer
D
D
Bishop
K
K
Solomon
E
E
Hodgson
S
S
McGurk
M
M
Hibbert
J
J
O'Connell
M
M
Partridge
M
M
Chevretton
E
E
Calman
F
F
Saunders
M
M
Shotton
K
K
Brown
A
A
Whittaker
S
S
Foulkes
W
W
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005979:Glutathione Peroxidase / Q000235:genetics*; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000235:genetics*; D018307:Neoplasms, Squamous Cell / Q000235:genetics*; D016017:Odds Ratio; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D000094765:Glutathione Peroxidase GPX1
D005979:Glutathione Peroxidase; D000094765:Glutathione Peroxidase GPX1; C000722067:GPX1 protein, human