Effects of allergen inhalation and oral glucocorticoid on concentrations of serum-soluble CD86 in allergic asthmatics.
The aim of the present study was to investigate effects of allergen inhalation and oral glucocorticoid on concentration of serum soluble CD86 in patients with allergic asthma. Our results showed that the serum soluble CD86 concentrations in the dual responder group increased from 491.8 +/- 15.4 IU/ml before allergen inhalation to 603.8 +/- 19.3 IU/ml 24 h after allergen inhalation. In the isolated early responders, there was no significant increase in serum soluble CD86 concentrations after allergen inhalation compared with baseline levels. There was a significant decrease in serum soluble CD86 concentrations after 2 weeks of glucocorticoid therapy (448.3 +/- 15.1 IU/ml) compared with baseline values (532.7 +/- 12.3 IU/ml), whereas there was no significant difference in the placebo group. This study has demonstrated that serum soluble CD86 concentrations increased after allergen inhalation in sensitized asthmatic subjects, and that serum sCD86 concentrations were downregulated by prednisolone therapy.
Deng
Jing-Min
JM
Departments of Respiratory and Critical Care Medicine, First Affiliated Hospital, Guangxi Medical University, Nanning 530021, Guangxi, People's Republic of China.
Shi
Huan-Zhong
HZ
Qin
Xue-Jun
XJ
Xie
Zheng-Fu
ZF
Huang
Chun-Ping
CP
Zhong
Xiao-Ning
XN
D000280:Administration, Inhalation; D000284:Administration, Oral; D000485:Allergens / Q000008:administration & dosage / Q000276:immunology; D015703:Antigens, CD / Q000097:blood*; D001249:Asthma / Q000097:blood* / Q000276:immunology; D051940:B7-2 Antigen; D001985:Bronchial Provocation Tests; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D011239:Prednisolone / Q000627:therapeutic use*; D039981:Pyroglyphidae / Q000276:immunology
D000485:Allergens; D015703:Antigens, CD; D051940:B7-2 Antigen; C497964:CD86 protein, human; D005938:Glucocorticoids; D008562:Membrane Glycoproteins; D011239:Prednisolone