Enforcing solution phase nanoscopic aggregation in a palindromic tripeptide.
C-terminal dimerization of a tripeptide palindrome afforded fibrillation in solution through an assembly probably driven by hydrogen bonding and hydrophobic contributions; such an approach provides an expeditious entry into fabrication of fibrillating peptides from non-fibrillating peptide sequences.
Prasad
K Krishna
KK
Department of Chemistry, Indian Institute of Technology-Kanpur, Kanpur-208016 (UP), India.
Purohit
C S
CS
Jain
Alok
A
Sankararamakrishnan
R
R
Verma
Sandeep
S
D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D018625:Microscopy, Atomic Force; D008958:Models, Molecular; D015394:Molecular Structure; D049329:Nanostructures / Q000737:chemistry*; D009842:Oligopeptides / Q000737:chemistry*; D020539:Sequence Analysis, Protein; D012996:Solutions / Q000737:chemistry
D009842:Oligopeptides; D012996:Solutions