Synthesis and characterization of polymeric soybean oil-g-methyl methacrylate (and n-butyl methacrylate) graft copolymers: biocompatibility and bacterial adhesion.
Peroxidation, epoxidation, and/or perepoxidation reactions of soybean oil under air at room temperature resulted in cross-linked polymeric soybean oil peroxides on the surface along with the waxy soluble part, sPSB, with a molecular weight of 4690, containing up to 2.3 wt % peroxide. This soluble polymeric oil peroxide, sPSB, initiated the free radical polymerization of either methyl methacrylate (MMA) or n-butyl methacrylate (nBMA) to give PSB-g-PMMA and PSB-g-PnBMA graft copolymers. The polymers obtained were characterized by (1)H NMR, thermogravimetric analysis, differential scanning calorimetry, and gel permeation chromatography techniques. Polymeric oil as a plasticizer lowered the glass transition of the PSB-g-PMMA graft copolymers. PSB-g-PMMA and PSB-g-PnBMA graft copolymer film samples were also used in cell culture studies. Fibroblast and macrophage cells were strongly adhered and spread on the copolymer film surfaces, which is important in tissue engineering. Bacterial adhesion on PSB-g-PMMA graft copolymer was also studied. Both Staphylococcus epidermidis and Escherichia coli adhered on the graft copolymer better than on homo-PMMA. Furthermore, the latter adhered much better than the former.
Cakmakli
Birten
B
Department of Chemistry, Faculty of Arts and Sciences, Zonguldak Karaelmas University, 67100 Zonguldak, Turkey.
Hazer
Baki
B
Tekin
Ishak Ozel
IO
Cömert
Füsun Begendik
FB
D000179:Acrylates / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001422:Bacterial Adhesion / Q000187:drug effects* / Q000502:physiology; D001672:Biocompatible Materials / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D051379:Mice; D011108:Polymers / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D013024:Soybean Oil / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000254:growth & development
D000179:Acrylates; D001672:Biocompatible Materials; D011108:Polymers; D013024:Soybean Oil; C035956:methyl acrylate