Effect of L-NAME on the synthesis of plasma fibrinogen in mice.
The effect of nitric oxide (NO) on plasma fibrinogen was investigated by treating mice with oral N(G)-nitro-L-arginine-methyl ester (L-NAME), a non-selective NO synthase (NOS) inhibitor. Treatment with L-NAME significantly increased the concentration of plasma fibrinogen and hepatic expression of the alpha- and beta-chains of fibrinogen, whereas plasma NO(2)(-) level and hepatic expression of endothelial NOS (eNOS) mRNA were significantly decreased. These results suggest that L-NAME treatment can increase plasma fibrinogen levels via an increase in expression of fibrinogen mRNA in the liver, and NO may be involved in plasma fibrinogen increase.
Takinishi
Yasutaka
Y
Department of Pharmacology, Showa University School of Medicine, Tokyo 142-8555, Japan.
Okazaki
Masako
M
Oguchi
Katsuji
K
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005340:Fibrinogen / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology*
D005340:Fibrinogen; D019331:NG-Nitroarginine Methyl Ester