title: A case of sick building syndrome in a Japanese office worker.
abstract: The adverse health effects caused by indoor air pollution are termed "sick building syndrome". We report such a patient whose symptoms appeared in the workplace. A 36-year-old female office worker developed nausea and headache during working hours in a refurbished office. After eight months of seeking help at other clinics or hospitals without improvement, she was referred to our hospital. At that time she reacted to the smells of various chemicals outside of the office building. Biochemical findings were all within normal ranges. Specific IgE antibody to cedar pollen was positive and the ratio of TH1/TH2 was 4.5. In the Eye Tracking Test (ETT), vertical eye movement was saccadic. Her anxiety level was very high according to the State-Trait Anxiety Inventory (STAI) questionnaire. Subjective symptoms, ETT findings and anxiety levels on STAI gradually improved during two years of follow-up. One year after the onset of her illness, the formaldehyde concentrations in the building air ranged from 0.017-0.053 ppm. Even though relatively low, chemical exposure from building materials such as formaldehyde induced a range of symptoms. Also, lack of recognition by superiors and doctors that sick building syndrome might have been the source of her illness coupled with her high state of anxiety may have exacerbated her symptoms and led to the onset of multiple chemical sensitivity. Thus psychosocial factors may contribute to sick building syndrome in the workplace.
authors.affiliation: Department of Otorhinolaryngology, Kansai Medical University, Fumizono-cho, Moriguchi, Osaka 570-8506, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Nakazawa
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ikeda
authors.forename: Toshio
authors.initials: T
authors.lastname: Yamashita
authors.forename: Ichiro
authors.initials: I
authors.lastname: Hara
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kumai
authors.forename: Ginji
authors.initials: G
authors.lastname: Endo
authors.forename: Yoko
authors.initials: Y
authors.lastname: Endo
mesh_terms: D000328:Adult; D005260:Female; D005557:Formaldehyde / Q000009:adverse effects / Q000032:analysis; D006801:Humans; D007564:Japan; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis*; D009930:Organic Chemicals / Q000009:adverse effects / Q000032:analysis; D012134:Respiratory Protective Devices; D018877:Sick Building Syndrome / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control
chemical_list: D009930:Organic Chemicals; D005557:Formaldehyde