Mediator and the mechanism of transcriptional activation.
Mediator was discovered because of its activity in a yeast RNA polymerase II (pol II) transcription system - it is needed for the system to respond to a transcriptional activator. Mediator is the central link in the enhancer-->activator-->Mediator-->pol II-->promoter pathway. The transduction of regulatory signals through this pathway is crucial for transcription of almost all pol II promoters in all eukaryote organisms.
Kornberg
Roger D
RD
Department of Structural Biology, Stanford School of Medicine, Stanford, CA 94305, USA. kornberg@stanford.edu
D000818:Animals; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D046912:Multiprotein Complexes / Q000378:metabolism; D012319:RNA Polymerase II / Q000378:metabolism*; D015534:Trans-Activators / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic; D015533:Transcriptional Activation
D005656:Fungal Proteins; D046912:Multiprotein Complexes; D015534:Trans-Activators; D014157:Transcription Factors; D012319:RNA Polymerase II