title: SCHIP: statistics for chromosome interphase positioning based on interchange data.
abstract: The position of chromosomes in the interphase nucleus is believed to be associated with a number of biological processes. Here, we present a web-based application that helps analyze the relative position of chromosomes during interphase in human cells, based on observed radiogenic chromosome aberrations. The inputs of the program are a table of yields of pairwise chromosome interchanges and a proposed chromosome geometric cluster. Each can either be uploaded or selected from provided datasets. The main outputs are P-values for the proposed chromosome clusters. SCHIP is designed to be used by a number of scientific communities interested in nuclear architecture, including cancer and cell biologists, radiation biologists and mathematical/computational biologists.
authors.affiliation: Departmento de Estadistica, Universidad de Barcelona Barcelona 08028, Spain.
authors.forename: Sergi
authors.initials: S
authors.lastname: Vives
authors.forename: Bradford
authors.initials: B
authors.lastname: Loucas
authors.forename: Mariel
authors.initials: M
authors.lastname: Vazquez
authors.forename: David J
authors.initials: DJ
authors.lastname: Brenner
authors.forename: Rainer K
authors.initials: RK
authors.lastname: Sachs
authors.forename: Lynn
authors.initials: L
authors.lastname: Hlatky
authors.forename: Michael
authors.initials: M
authors.lastname: Cornforth
authors.forename: Javier
authors.initials: J
authors.lastname: Arsuaga
mesh_terms: D002869:Chromosome Aberrations / Q000528:radiation effects*; D002874:Chromosome Mapping / Q000379:methods*; D003627:Data Interpretation, Statistical; D007399:Interphase / Q000235:genetics* / Q000528:radiation effects; D008957:Models, Genetic; D015233:Models, Statistical; D012854:Sister Chromatid Exchange / Q000235:genetics* / Q000528:radiation effects; D012984:Software; D014584:User-Computer Interface