[Clinical observation of liver damages in epidemic hemorrhagic fever].
OBJECTIVE
To study the changes in liver function in patients with epidemic hemorrhagic fever (EHF).


METHODS
A retrospective analysis of the laboratory tests of liver function in 103 patients with EHF and control subjects was carried out.


RESULTS
The alanine aminotransferase (ALT), serum bilirubin (SB) and albumin levels in patients with severe and critical liver damages significantly differed from those in milder cases, and more sever liver damages were found in the death cases of EHF than in survived patients in terms of ALT and SB increment (P=0.000). The liver damage was related to the clinical type, age and the levels of blood platelet , albumin, lactic dehydrogenase and creatinine in EHF cases (P=0.000, 0.000, 0.030, 0.010, 0.000 and 0.013, respectively).


CONCLUSIONS
Liver damage is common in patients with EHF and exacerbates with the severity of the disease. Monitoring of ALT, SB and albumin is helpful for evaluating the progression and prognosis of EHF.
Tang
Zheng-yun
ZY
Department of Infection Diseases, Second Affiliated Hospital of Guangzhou Medical College, Guangzhou 510260, China.
Ye
Xiao-guang
XG
Liao
Yun-zhen
YZ
Li
Shi-hao
SH
D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D001663:Bilirubin / Q000097:blood; D005260:Female; D006480:Hemorrhagic Fever with Renal Syndrome / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008099:Liver / Q000473:pathology / Q000503:physiopathology*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012709:Serum Albumin / Q000378:metabolism
D012709:Serum Albumin; D000410:Alanine Transaminase; D001663:Bilirubin