Cholesteryl ester transfer protein TaqI B and lipoprotein lipase Ser447Ter gene polymorphisms are not associated with ischaemic stroke in Greek patients.
Cholesteryl ester transfer protein (CETP) and lipoprotein lipase (LPL) are both key players in plasma lipoprotein homeostasis and, as such, genetically induced alterations in their respective activities may affect susceptibility to cerebrovascular diseases. In this study, we examined the distribution of two common polymorphisms, namely CETP TaqI B and LPL Ser447Ter in a cohort of Greek clinically diagnosed late-onset ischaemic stroke patients (n = 98) and an ethnicity-, age- and sex-matched control group with no manifestations of vascular disease (n = 100). Our study revealed no statistically significant differences with respect to the distribution of either polymorphism, examined separately or in combination, between the two groups.
Fidani
Liana
L
Department of General Biology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece. lfidani@med.auth.gr
Hatzitolios
Apostolos I
AI
Goulas
Antonis
A
Savopoulos
Christos
C
Basayannis
Christos
C
Kotsis
Alexandros
A
D000368:Aged; D000369:Aged, 80 and over; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D053480:Cholesterol Ester Transfer Proteins; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006023:Glycoproteins / Q000235:genetics*; D006115:Greece / Q000453:epidemiology; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics*; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D012694:Serine / Q000235:genetics*; D020521:Stroke / Q000235:genetics*
C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D006023:Glycoproteins; D012694:Serine; D008071:Lipoprotein Lipase