Cathelicidins--nature's attempt at combinatorial chemistry.
Cathelicidins are a family of diverse antimicrobial peptides found in granules of mammalian neutrophils. Cathelicidins are active against a broad range of microbes in different environments. Aside from their antimicrobial activity, cathelicidins possess other biological properties including cytotoxic activity towards mammalian cells. Several studies have shown that the amino acid sequence of cathelicidins can be modified to temper undesired properties, such as hemolytic and cytotoxic activity, and at the same time maintain antimicrobial activity. These properties make cathelicidins ideal templates in combinatorial chemistry for designing de novo antimicrobial peptides for therapeutic use. However, one of the major challenges will be to screen these peptides in experimentally relevant models that reflect the environments in which the peptides should be therapeutically active.
Sorensen
Ole E
OE
Department of Cell and Molecular Biology, Section ofMolecular Pathogenesis, Lund University, Sweden. Ole_E.Sorensen@medkem.lu.se
Borregaard
Niels
N
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D054804:Cathelicidins; D020650:Combinatorial Chemistry Techniques; D003601:Cytotoxicity Tests, Immunologic; D015195:Drug Design; D024881:Drug Resistance, Bacterial; D006801:Humans; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D054804:Cathelicidins