title: Are the high levels of cytomegalovirus antibodies a determinant in the development of coronary artery disease?
abstract: In several epidemiological studies, it was suggested that a high titer of cytomegalo-virus (CMV) antibody meant CMV reactivation, and that this condition was a determinant of coronary artery disease (CAD). The purpose of this study was to investigate both the prevalence of the CMV infections in our study population and whether high CMV sero-positivity is a determinant of CAD. Blood samples from 179 (58 female, 121 male) individuals being evaluated for CAD suspicion by coronary angiography were tested for CMV seropositivity and CRP levels. Fifty-six patients had normal coronary arteries and 123 patients had CAD. Six patients did not have anti-CMV antibodies and 87 of the 173 seropositive patients had high levels of anti-CMV antibodies (> or = 8 U/mL). High CMV seropositivity (> or = 8 U/mL) was a significant CAD determinant even after adjustment for traditional CAD risk factors (odds ratio [OR] = 2.1 P = 0.04, respectively). The results indicate that the prevalence of high CMV seropositivity is an independent predictor of CAD in our study population and that our study population with CAD had a high rate of CMV infection.
authors.affiliation: Department of Cardiology, Erciyes University Medical School, Kayseri, Turkey.
authors.forename: Namik Kemal
authors.initials: NK
authors.lastname: Eryol
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Kiliç
authors.forename: Ali
authors.initials: A
authors.lastname: Gül
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Ozdogru
authors.forename: Tugrul
authors.initials: T
authors.lastname: Inanç
authors.forename: Ali
authors.initials: A
authors.lastname: Dogan
authors.forename: Ramazan
authors.initials: R
authors.lastname: Topsakal
authors.forename: Emrullah
authors.initials: E
authors.lastname: Basar
mesh_terms: D000368:Aged; D000914:Antibodies, Viral / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000276:immunology*; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D002097:C-Reactive Protein