title: Diagnosis and treatment of neonatal hypotension outside the transitional period.
abstract: The etiology and pathophysiology of the circulatory compromise are among the primary determinants of the clinical presentation of patients with neonatal shock. Therefore, in the absence of direct assessment of cardiac output and organ blood flow, the characteristic clinical presentation itself may guide the initial management of the circulatory compromise. This chapter discusses different pathophysiology-driven management approaches to a number of characteristic clinical presentations of neonatal shock. The clinical presentations discussed in detail are the hypotensive very low birth weight neonate with a hemodynamically significant patent ductus arteriosus, and the preterm or term neonate with perinatal depression, pressor/inotrope resistance and relative adrenal insufficiency, and with specific systemic inflammatory response syndrome. In the absence of information from appropriately designed, randomized clinical trials, management of neonatal shock remains based on pathophysiology and experience. Thus, as there is little evidence for the effectiveness of these management approaches to improve mortality and short-and long-term outcome, the therapeutic approaches described in this chapter should be carefully evaluated and cautiously entertained when treating a neonate with circulatory compromise.
authors.affiliation: Keck School of Medicine, University of Southern California, Childrens Hospital Los Angeles and Women's and Children's Hospital of the LAC+USC Medical Center, 90027, United States. iseri@chla.usc.edu
authors.forename: Istvan
authors.initials: I
authors.lastname: Seri
authors.forename: Shahab
authors.initials: S
authors.lastname: Noori
mesh_terms: D000309:Adrenal Insufficiency / Q000188:drug therapy / Q000503:physiopathology; D004280:Dobutamine / Q000627:therapeutic use; D004298:Dopamine / Q000627:therapeutic use; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007022:Hypotension / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D019102:Infant, Very Low Birth Weight; D020105:Milrinone / Q000627:therapeutic use; D009359:Neonatology / Q000639:trends; D012770:Shock, Cardiogenic / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D018746:Systemic Inflammatory Response Syndrome / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D004280:Dobutamine; D020105:Milrinone; D004298:Dopamine