Perinuclear antineutrophil cytoplasmic antibody myeloperoxidase-positive vasculitis in association with ulcerative colitis.
We describe a patient with ulcerative colitis (UC) who developed small vessel vasculitis. Perinuclear antineutrophil cytoplasmic antibody myeloperoxidase (p-ANCA-MPO) positivity was detected along with a highly elevated titer of anticardiolipin antibodies. A total proctocolectomy was undertaken and the patient, more than 5 years later, remains in very good condition. The possible causative association between the UC, the p-ANCA-MPO-positive small vessel vasculitis, and the anticardiolipin antibodies is discussed.
Panani
Anna D
AD
Critical Care Department, Evangelismos Hospital, Medical School of Athens University, Ipsilantou 45-47, Athens, 10676, Greece. apanani@med.uoa.gr
Grigoriadou
Maria
M
Magira
Eleni
E
Roussos
Charis
C
Raptis
Sotirios A
SA
D017153:Antibodies, Anticardiolipin / Q000097:blood; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D003093:Colitis, Ulcerative / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000378:metabolism*; D011239:Prednisolone / Q000627:therapeutic use; D016896:Treatment Outcome; D014657:Vasculitis / Q000150:complications / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*
D017153:Antibodies, Anticardiolipin; D019268:Antibodies, Antineutrophil Cytoplasmic; D011239:Prednisolone; D009195:Peroxidase