Synthesis of some new steroidal [16alpha,17alpha-d]-isoxazolines.
Regioselective synthesis of novel steroidal anti-inflammatory ante drug analogues, viz., [16alpha,17alpha-d]-isoxazolines 1(a-h) and 2(a-h) prepared in a single step in good yield by the reaction of 16-dehydropregnenolone acetate (16-DPA) 1 or related 21-chloro-20-oxopregnane 2 with various aldoximes (a-h) in presence of chloramine-T in refluxing ethanol.
Chowdhury
Pritish
P
Natural Products Chemistry Division, Regional Research Laboratory, Jorhat 785006, India. pritishchowdhury@yahoo.com
Das
Archana Moni
AM
Goswami
Papori
P
D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002700:Chloramines / Q000737:chemistry; D000431:Ethanol / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000737:chemistry; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013058:Mass Spectrometry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010091:Oximes / Q000737:chemistry; D011278:Pregnanes / Q000737:chemistry; D011284:Pregnenolone / Q000031:analogs & derivatives / Q000737:chemistry; D013256:Steroids / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship; D014105:Tosyl Compounds / Q000737:chemistry
D000893:Anti-Inflammatory Agents; D002700:Chloramines; D006571:Heterocyclic Compounds; D007555:Isoxazoles; D010091:Oximes; D011278:Pregnanes; D013256:Steroids; D014105:Tosyl Compounds; C016300:chloramine-T; D000431:Ethanol; C003592:16-dehydropregnenolone; D011284:Pregnenolone