Peripheral glia: Schwann cells in motion.
Neuregulin signaling through ErbB receptors is known to play an essential role in Schwann cell proliferation, survival and myelination. Recent studies in zebrafish provide a peek at living Schwann cells migrating along axons in vivo and suggest that ErbB signaling, while not required for cell movement per se, is required to maintain the directed migration of these cells.
Lai
Cary
C
The Scripps Institute, La Jolla, CA 92037, USA. carylai@scripps.edu
D000818:Animals; D001369:Axons / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D049109:Cell Proliferation; D009154:Mutation / Q000235:genetics; D009186:Myelin Sheath / Q000378:metabolism*; D020880:Neuregulins / Q000378:metabolism*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D012583:Schwann Cells / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D015027:Zebrafish
D020880:Neuregulins; D018719:Erb-b2 Receptor Tyrosine Kinases