title: Unexpected results using rapid intraoperative parathyroid hormone monitoring during parathyroidectomy for primary hyperparathyroidism.
abstract: Rapid intraoperative parathyroid hormone (RIOPTH) monitoring predicts complete removal of all hypersecreting tissue by means of a significant parathyroid hormone (PTH) decrease. In this study we have tried to provide an explanation for some unexpected results of RIOPTH monitoring observed during a series of 125 conventional parathyroidectomies for primary hyperthyroidism, discussing the possible consequences on the surgical strategy. Three main groups can be recognized: (1) spikes: a PTH increase 10 minutes after removal of the diseased gland was observed in three patients; (2) false-negative results: six patients showed an inadequate PTH decreases at 10 minutes, three of them resulting in cure at 20 minutes (all six patients were cured at follow-up); (3) false-positive results: five patients with multiglandular disease showed a PTH decrease to a cure level despite excision of one adenoma only (in two of these patients a 20-minute sample showed a PTH increase soon after manipulation of the second adenoma). We concluded that the spike, almost certainly a consequence of manipulating the adenoma, when detected should be considered the "true" baseline value. False-negative results are to some extent related to undetected spikes. The assay used for RIOPTH determination and PTH half-life variability may also play a role. A false-negative result usually prolongs the surgical time. False-positive results are usually related to a double adenoma, one functionally prevailing over the other. Because in our experience manipulation of the second adenoma brought a PTH increase detected with RIOPTH monitoring, we believe that the second adenoma should be excised.
authors.affiliation: General Surgery Division, Santa Croce e Carle Hospital, Via M. Coppino 26, Cuneo, 12100, Italy. emmolo.i@ospedale.cuneo.it
authors.forename: Ignazio
authors.initials: I
authors.lastname: Emmolo
authors.forename: Herbert Dal
authors.initials: HD
authors.lastname: Corso
authors.forename: Giorgio
authors.initials: G
authors.lastname: Borretta
authors.forename: Gianluca
authors.initials: G
authors.lastname: Visconti
authors.forename: Alessandro
authors.initials: A
authors.lastname: Piovesan
authors.forename: Flora
authors.initials: F
authors.lastname: Cesario
authors.forename: Felice
authors.initials: F
authors.lastname: Borghi
mesh_terms: D000368:Aged; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods*; D010280:Parathyroid Glands / Q000378:metabolism; D010281:Parathyroid Hormone / Q000097:blood*; D016105:Parathyroidectomy; D010812:Physical Stimulation; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D010281:Parathyroid Hormone