Immunological insights from genetic vaccines.
E1-deleted adenoviral vectors expressing the rabies virus glycoprotein rapidly induce protective titers of rabies virus neutralizing antibodies in adult and neonatal mice upon systemic or mucosal immunization. Pre-existing immunity in humans due to natural infections with common human serotypes of adenovirus such as the human serotype 5, most commonly used as a vaccine carrier can be circumvented by systemic immunization with a simian-origin adenovirus or by using the oral route of immunization. Virus neutralizing antibody titers can be enhanced by prime-boost regimens.
Ertl
Hildegund C J
HC
The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA. ertl@wistar.upenn.edu
D000256:Adenoviridae / Q000235:genetics*; D017498:Adenovirus E1 Proteins / Q000172:deficiency / Q000235:genetics; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000276:immunology; D005822:Genetic Vectors / Q000235:genetics; D051379:Mice; D011819:Rabies Vaccines / Q000008:administration & dosage* / Q000235:genetics / Q000276:immunology; D014611:Vaccination; D019444:Vaccines, DNA / Q000008:administration & dosage* / Q000235:genetics / Q000276:immunology
D017498:Adenovirus E1 Proteins; D000914:Antibodies, Viral; D011819:Rabies Vaccines; D019444:Vaccines, DNA