title: Brain perfusion differences between Parkinson's disease and multiple system atrophy with predominant parkinsonian features.
abstract: BACKGROUND
  The patterns of regional cerebral blood flow in Parkinson's disease and multiple system atrophy remain inconsistent.
  
  
  OBJECTIVE
  To compare brain perfusion images of 123I-IMP SPECT between Parkinson's disease, multiple system atrophy with predominant parkinsonian features (MSA-P) and controls.
  
  
  METHODS
  Eighty-two patients with Parkinson's disease, 10 patients with MSA-P and 14 controls were studied. We performed 3D-SSP and volume of interest analysis using 123I-IMP scintigraphy.
  
  
  RESULTS
  Occipital perfusion of MSA-P increased compared to that of Parkinson's disease and perfusion in the cerebellum and primary sensorimotor cortex of Parkinson's disease increased compared to that of MSA-P. Perfusion in the putamen of MSA-P decreased compared to that of Parkinson's disease.
  
  
  CONCLUSIONS
  Our study demonstrated perfusion differences in 123I-IMP SPECT between the two diseases.
authors.affiliation: Department of Neurology, Sumitomo Hospital, 5-3-20 Nakanoshima, Osaka 530-0005, Japan. matsui-hideaki@sumitomo-hp.or.jp
authors.forename: Hideaki
authors.initials: H
authors.lastname: Matsui
authors.forename: Fukashi
authors.initials: F
authors.lastname: Udaka
authors.forename: Takafumi
authors.initials: T
authors.lastname: Miyoshi
authors.forename: Narihiro
authors.initials: N
authors.lastname: Hara
authors.forename: Akiko
authors.initials: A
authors.lastname: Tamura
authors.forename: Masaya
authors.initials: M
authors.lastname: Oda
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Kubori
authors.forename: Kazuto
authors.initials: K
authors.lastname: Nishinaka
authors.forename: Masakuni
authors.initials: M
authors.lastname: Kameyama
mesh_terms: D000368:Aged; D002560:Cerebrovascular Circulation; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000000981:diagnostic imaging* / Q000503:physiopathology; D010300:Parkinson Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals