title: Outcomes of pregnancy complicated by thyroid disease.
abstract: OBJECTIVE
  To perform a case note review of pregnancies complicated by thyroid dysfunction to determine management and therapeutic intervention in relation to pregnancy outcome.
  
  
  METHODS
  A retrospective case note analysis of 81 ongoing pregnancies in 70 pregnant women with a history of thyroid dysfunction over a period of 5 years at the Glasgow Royal Maternity Hospital (GRMH), Glasgow, Scotland, United Kingdom. The results of thyroid function tests and whether a change in treatment was instituted were recorded. Thyroid function was assessed by standard laboratory reference ranges for free thyroxine (FT4) and thyroid stimulating hormone (TSH) in all trimesters. Other parameters were also noted.
  
  
  RESULTS
  Medication levels needed to be increased in the hypothyroid group (45%), and decreased (38%) in the hyperthyroid group.
  
  
  CONCLUSIONS
  Pregnancy outcome was good in majority of cases given appropriate replacement therapy for stated reference values.
authors.affiliation: Department of Obstetrics & Gynaecology, Glasgow Royal Infirmary, Glasgow, UK. lyndalharborne@yahoo.co.uk
authors.forename: Lyndal R
authors.initials: LR
authors.lastname: Harborne
authors.forename: Claire E
authors.initials: CE
authors.lastname: Alexander
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Thomson
authors.forename: Denis St J
authors.initials: DS
authors.lastname: O'Reilly
authors.forename: Ian A
authors.initials: IA
authors.lastname: Greer
mesh_terms: D013956:Antithyroid Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002231:Carbimazole / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005865:Gestational Age; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy* / Q000503:physiopathology; D007037:Hypothyroidism / Q000188:drug therapy* / Q000503:physiopathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy* / Q000503:physiopathology; D011256:Pregnancy Outcome; D011441:Propylthiouracil / Q000008:administration & dosage / Q000627:therapeutic use; D012189:Retrospective Studies; D012307:Risk Factors; D013960:Thyroid Function Tests; D013974:Thyroxine / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D013956:Antithyroid Agents; D011441:Propylthiouracil; D002231:Carbimazole; D013974:Thyroxine