title: A review of studies describing the use of acetyl cholinesterase inhibitors in Parkinson's disease dementia.
abstract: OBJECTIVE
  To review the literature relating to the use of acetyl cholinesterase inhibitors in Parkinson's disease dementia (PDD).
  
  
  METHODS
  MEDLINE (1966--December 2004), PsychINFO (1972--December 2004), EMBASE (1980--December 2004), CINHAL (1982--December 2004), and the Cochrane Collaboration were searched in December 2004.
  
  
  RESULTS
  Three controlled trials and seven open studies were identified. Efficacy was assessed in three key domains: cognitive, neuropsychiatric and parkinsonian symptoms.
  
  
  CONCLUSIONS
  Cholinesterase inhibitors have a moderate effect against cognitive symptoms. There is no clear evidence of a noticeable clinical effect against neuropsychiatric symptoms. Tolerability including exacerbation of motor symptoms--in particular tremor--may limit the utility of cholinesterase inhibitors.
authors.affiliation: East Kent NHS & SCPT, UK. ian.maidment@nhs.net
authors.forename: I D
authors.initials: ID
authors.lastname: Maidment
authors.forename: C
authors.initials: C
authors.lastname: Fox
authors.forename: M
authors.initials: M
authors.lastname: Boustani
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002800:Cholinesterase Inhibitors / Q000145:classification / Q000627:therapeutic use*; D003704:Dementia / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications*; D016032:Randomized Controlled Trials as Topic
chemical_list: D002800:Cholinesterase Inhibitors