Cytotoxic activity of embelin from Lysimachia punctata.
A major benzoquinone pigment, embelin (1), was isolated from the underground parts of Lysimachia punctata. Compound 1 showed a significant cytotoxic activity in vitro against B16 and XC cell lines with ED50 values of 13 microg/ml and 8 microg/ml, respectively.
Podolak
Irma
I
Department of Pharmacognosy, Collegium Medicum Jagiellonian University, Medyczna 9, 30-688 Cracow, Poland. mfpodola@cyf-kr.edu.pl
Galanty
Agnieszka
A
Janeczko
Zbigniew
Z
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D016227:Benzoquinones / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015394:Molecular Structure; D029623:Primulaceae / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D016227:Benzoquinones; C010945:embelin