Retention and repression: fates of hyperedited RNAs in the nucleus.
Double-stranded RNA (dsRNA) is often formed in the nuclei of mammalian cells, but in this compartment it does not induce the effects characteristic of cytoplasmic dsRNA. Rather, recent work has suggested that nuclear dsRNA is a target for the ADAR class of enzymes, which deaminate adenosines to inosines. Further, there are a number of distinct fates of such edited RNA, including nuclear retention and perhaps also gene silencing.
DeCerbo
Joshua
J
Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030-3301, USA.
Carmichael
Gordon G
GG
D021581:Active Transport, Cell Nucleus / Q000502:physiology; D000243:Adenosine Deaminase / Q000378:metabolism; D000818:Animals; D034961:Antigens, Nuclear / Q000378:metabolism; D001324:Autoantigens / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism*; D053487:DEAD-box RNA Helicases; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D000072200:Ku Autoantigen; D008954:Models, Biological; D009363:Neoplasm Proteins; D009687:Nuclear Proteins / Q000378:metabolism / Q000502:physiology; D017393:RNA Editing; D020365:RNA Helicases / Q000378:metabolism; D034622:RNA Interference / Q000502:physiology*; D034443:RNA Transport / Q000502:physiology; D012330:RNA, Double-Stranded / Q000235:genetics / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism
D034961:Antigens, Nuclear; D001324:Autoantigens; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D012330:RNA, Double-Stranded; D016601:RNA-Binding Proteins; C068873:matrin 3, rat; C567955:ADARB1 protein, human; D000243:Adenosine Deaminase; C098487:DHX9 protein, human; C000606509:Xrcc6 protein, human; C000606511:Xrcc6 protein, rat; D053487:DEAD-box RNA Helicases; D020365:RNA Helicases; D000072200:Ku Autoantigen