Effect of calcium trisodium DTPA in rats with puncture wound contaminated by 90Y-chloride.
The efficacy of diethylenetriaminepentaacetate calcium trisodium (CaNa(3)DTPA) in a dose of 34.7 micromol kg(-1) as a function of its route of administration was investigated in rats with a puncture wound contaminated by (90)Y-chloride at a concentration of 2.55 MBq kg(-1). Approximately 60% of (90)Y-chloride at a puncture wound was absorbed into the body of rats over 72 h post-puncture and radioactivity in femoral bone increased during the timed-release of (90)Y. Intravenous administration of CaNa(3)DTPA (systemic treatment) at 15 min post-puncture reduced (90)Y at a puncture wound and in bone up to 75.6 and 84.3% of controls, respectively. Direct infiltration of CaNa(3)DTPA into a puncture wound site (local treatment) at 15 min post-puncture diminished radioactivity at the puncture wound and in bone up to 34.9 and 52.5% of controls, respectively. Thus, prompt local treatment may be effective for removing (90)Y from a puncture wound and minimising (90)Y-distribution to bone compared with systemic treatment.
Watanabe
N
N
Department of Medical Imaging, National Institute of Radiological Sciences, Chiba 263-8555, Japan. N.Watanabe@iaea.org
Tanada
S
S
Sasaki
Y
Y
D000818:Animals; D001822:Body Burden; D002614:Chelating Agents / Q000008:administration & dosage; D003666:Decontamination / Q000379:methods*; D005260:Female; D007267:Injections; D008657:Metabolic Clearance Rate / Q000187:drug effects; D004369:Pentetic Acid / Q000008:administration & dosage*; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000209:etiology / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D012062:Relative Biological Effectiveness; D014018:Tissue Distribution / Q000187:drug effects; D016896:Treatment Outcome; D014950:Wounds, Penetrating / Q000378:metabolism*; D015019:Yttrium / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics*
D002614:Chelating Agents; D011837:Radiation-Protective Agents; C064782:yttrium chloride; D015019:Yttrium; D004369:Pentetic Acid