HSP27 and cell death in spinocerebellar ataxia type 3.
Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant spinocerebellar degeneration characterized by a wide range of clinical manifestations. In this review, we discuss the role(s) that heat shock protein 27 (HSP27) may play in the cell death process of spinocerebellar ataxia type 3.
Hsieh
Mingli
M
Department of Life Science, Tunghai University, Taichung, Taiwan, Republic of China. mhsieh@mail.thu.edu.tw
Tsai
Hui-Fang
HF
Chang
Wei-Hsiu
WH
D000818:Animals; D016923:Cell Death / Q000502:physiology; D055551:HSP27 Heat-Shock Proteins; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D017827:Machado-Joseph Disease / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D008954:Models, Biological; D018832:Molecular Chaperones; D009363:Neoplasm Proteins / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
D055551:HSP27 Heat-Shock Proteins; C057725:HSPB1 protein, human; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D009363:Neoplasm Proteins