title: Acute NMDA receptor antagonism induces biphasic striatal utilization of L-[beta-11C]DOPA: PET studies in the conscious monkey brain.
authors.affiliation: Central Research Laboratory, Hamamatsu Photonics K.K., Hamakita, Shizuoka 434-8601, Japan. tsukada@crl.hpk.co.jp
authors.forename: Hideo
authors.initials: H
authors.lastname: Tsukada
authors.forename: Norihiro
authors.initials: N
authors.lastname: Harada
authors.forename: Shingo
authors.initials: S
authors.lastname: Nishiyama
authors.forename: Dai
authors.initials: D
authors.lastname: Fukumoto
authors.forename: Takeharu
authors.initials: T
authors.lastname: Kakiuchi
mesh_terms: D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects / Q000502:physiology; D002250:Carbon Radioisotopes; D003042:Cocaine / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D003243:Consciousness / Q000502:physiology; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D018698:Glutamic Acid / Q000378:metabolism; D007980:Levodopa / Q000378:metabolism* / Q000493:pharmacokinetics; D008253:Macaca mulatta; D008297:Male; D009434:Neural Pathways / Q000187:drug effects / Q000378:metabolism; D049268:Positron-Emission Tomography / Q000379:methods; D017729:Presynaptic Terminals / Q000187:drug effects / Q000378:metabolism; D020891:Raclopride / Q000493:pharmacokinetics; D017448:Receptors, Dopamine D2 / Q000819:agonists / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
chemical_list: D002250:Carbon Radioisotopes; D018691:Excitatory Amino Acid Antagonists; D017448:Receptors, Dopamine D2; D016194:Receptors, N-Methyl-D-Aspartate; D018698:Glutamic Acid; D020891:Raclopride; D007980:Levodopa; C021279:(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester; D003042:Cocaine; D004298:Dopamine