Preeclampsia: a renal perspective.
Preeclampsia is a syndrome that affects 5% of all pregnancies, producing substantial maternal and perinatal morbidity and mortality. The aim of this review is to summarize our current understanding of the pathogenesis of preeclampsia with special emphasis on the recent discovery that circulating anti-angiogenic proteins of placental origin may play an important role in the pathogenesis of proteinuria and hypertension of preeclampsia.
Karumanchi
S Ananth
SA
Renal Division and Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA. sananth@bidmc.harvard.edu
Maynard
Sharon E
SE
Stillman
Isaac E
IE
Epstein
Franklin H
FH
Sukhatme
Vikas P
VP
D005260:Female; D017359:HELLP Syndrome / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007668:Kidney / Q000473:pathology; D010920:Placenta / Q000502:physiology; D011225:Pre-Eclampsia / Q000150:complications / Q000209:etiology*; D011247:Pregnancy; D011507:Proteinuria / Q000209:etiology; D012307:Risk Factors; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology
D042461:Vascular Endothelial Growth Factor A