title: [Topical administration of hydralazine hydrochloride on the viability of randon skin flaps in rats].
abstract: OBJECTIVE
  Assess the effect of hydralazine hydrochloride, for iontophoresis, on the viability of random skin flaps in rats.
  
  
  METHODS
  Sixty Wistar rats was randonly destributed in 4 groups (n=15), these animals was submited as randon dorsal skin flaps as cranial base with measure 10 x 4 cm. The animals from group 1 was utilized as control, in group 2 was submitted to direct current o 4mA-20' immediately after the surgery and on the two subsequent days. In group 3 the stimulation eletric simulation with hydralazine hydrochloride. In group 4 iontophorese with hydralazine hydrochloride 4mA-20'. The analysis of the results was made on the seventh day post operative and interpreted with test non parametric of Kruskal-Wallis.
  
  
  RESULTS
  and the necrotic area stayed fixed in: group 1=45%; group 2=39%; group 3=46% and group 4=41%, being the statistical analysis did not evidenced any significant.
  
  
  CONCLUSIONS
  The hydralazine hydrochloride when taken for iontophorese was not efficacious in reduce the necrotic area.
authors.affiliation: Curso de Fisioterapia da Universidade Paulista. ivaldofisio@ig.com.br
authors.forename: Ivaldo Esteves
authors.initials: IE
authors.lastname: Junior
authors.forename: Igor Bordello
authors.initials: IB
authors.lastname: Masson
authors.forename: Lydia Masako
authors.initials: LM
authors.lastname: Ferreira
authors.forename: Richard Eloin
authors.initials: RE
authors.lastname: Liebano
authors.forename: Cristiano
authors.initials: C
authors.lastname: Baldan
authors.forename: Alexandre Cavallieri
authors.initials: AC
authors.lastname: Gomes
mesh_terms: D000287:Administration, Topical; D000818:Animals; D006830:Hydralazine / Q000008:administration & dosage*; D007478:Iontophoresis; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013524:Surgical Flaps
chemical_list: D006830:Hydralazine