title: Vascular involvement in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes.
abstract: A 26-year-old man with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) was admitted to our hospital for further cardiovascular examination. A muscle biopsy demonstrated strongly succinate dehydrogenase-reactive blood vessels. Pulse wave contour analysis revealed that both capacitive and oscillatory compliance were markedly reduced in this patient compared with 45 normal age-matched control subjects. Hepatocyte growth factor was remarkably elevated in this patient over that of 10 normal control subjects. These findings suggest that a MELAS patient has not only pathologic but also functional vascular involvement. If so, patients with MELAS need systemic vascular assessment.
authors.affiliation: Division of Cardiovascular Medicine, Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo City, Shimane, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Takahashi
authors.forename: Toshio
authors.initials: T
authors.lastname: Shimada
authors.forename: Yo
authors.initials: Y
authors.lastname: Murakami
authors.forename: Harumi
authors.initials: H
authors.lastname: Katoh
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Oyake
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Ishibashi
authors.forename: Ichizo
authors.initials: I
authors.lastname: Nishino
authors.forename: Ikuya
authors.initials: I
authors.lastname: Nonaka
authors.forename: Yu-Ichi
authors.initials: Y
authors.lastname: Goto
mesh_terms: D000328:Adult; D001808:Blood Vessels / Q000201:enzymology; D017228:Hepatocyte Growth Factor / Q000096:biosynthesis / Q000097:blood; D006801:Humans; D017241:MELAS Syndrome / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D018482:Muscle, Skeletal / Q000098:blood supply / Q000473:pathology; D013385:Succinate Dehydrogenase / Q000378:metabolism; D014652:Vascular Diseases / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*
chemical_list: D017228:Hepatocyte Growth Factor; D013385:Succinate Dehydrogenase