Genotoxicity and sister chromatid exchange in patients with myelodysplastic disorders.
In this study, we aimed to evaluate genotoxicity by sister chromatid exchange frequency in the peripheral lymphocytes of patients with myelodysplastic syndrome (MDS). The study population consisted of 16 patients (females/males:6/10; mean age: 61.68 +/- 13.08 years) diagnosed with "refractory anemia" according to FAB classification. The results were compared with an age- and sex-matched control group. The sister chromatid exchange frequency in the study group was found to be significantly higher than the control group (8.3 +/- 11 vs. 6.83 +/- 1.07, P=0.0046). We suggest that increased DNA damage, which is revealed by the increased sister chromatid exchange in the present study may play a role in the etiopathogenesis of MDS.
Oztürk
Sükrü
S
Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Medical Genetics, Capa- Fatih, Istanbul, Turkey. sozturk@istanbul.edu.tr
Palanduz
Sükrü
S
Cefle
Kivanç
K
Tutkan
Gülçin
G
Uçur
Ali
A
Dinçol
Günçağ
G
Nalçaci
Meliha
M
Aktan
Melih
M
Yavuz
Selim
S
Küçükkaya
Reyhan Diz
RD
D000328:Adult; D000368:Aged; D004249:DNA Damage; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D012854:Sister Chromatid Exchange