Glycosoaminoglycans in nasal polyps.
CONCLUSIONS
The qualitative and quantitative compositions of GAGs were comparable in all the polyps examined.


OBJECTIVE
Glycosoaminoglycans (GAGs) are an integral component of proteoglycans, which are constituents of connective tissue. The qualitative and quantitative compositions of GAGs occurring in proteoglycans determine their biological role. In this work, individual fractions of GAGs occurring in nasal polyps were isolated and estimated.


METHODS
Polyps were obtained over a 2-year period from 31 patients (18 males, 13 females; age range 28-70 years) who underwent polypectomy and evaluated using routine histopathology.


RESULTS
The amount of hyaluronic acid in nasal polyps was high, the amounts of dermatane sulphate and chondroitine-6-sulphate were slightly lower and the amounts of chondroitine-4-sulphate, heparin, heparan sulphate and keratan sulphate were the lowest.
Pawłowska-Góral
Katarzyna
K
Department of General and Analytical Chemistry, Silesian Academy of Medicine, Sosnowiec, Poland. katarzynagor@wp.pl
Gierek
Tatiana
T
Majzel
Krystyna
K
Wardas
Piotr
P
Wardas
Maria
M
D000328:Adult; D000368:Aged; D002809:Chondroitin Sulfates / Q000032:analysis; D003871:Dermatan Sulfate / Q000032:analysis; D005260:Female; D006025:Glycosaminoglycans / Q000032:analysis*; D006493:Heparin / Q000032:analysis; D006497:Heparan Sulfate / Q000032:analysis; D006801:Humans; D006820:Hyaluronic Acid / Q000032:analysis; D007632:Keratan Sulfate / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000737:chemistry* / Q000601:surgery
D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D006025:Glycosaminoglycans; D006493:Heparin; D006497:Heparan Sulfate; D006820:Hyaluronic Acid; D007632:Keratan Sulfate