Rapid learning and flexible memory in "habit" tasks in rats trained with brain stimulation reward.
Two groups of rats, one rewarded with sweetened food and the other rewarded with medial forebrain bundle (MFB) stimulation, were trained to home in on and dig for a buried object coated with a target odor. After each group had 15 training trials, MFB rats searched with greater accuracy and speed than food-rewarded rats. MFB rats were subsequently tested (1) after 6 weeks with no additional practice; (2) with food or non-food distractor odors, and (3) with major spatial alterations to the search environment, and in all cases searched with the same high accuracy, short search time, and low level of distractibility as in baseline. These results suggest that the high motivation provided by MFB reward engenders rapidly formed, long-lasting, and surprisingly flexibly deployable "habit" memories.
Hermer-Vazquez
Linda
L
Department of Physiology and Pharmacology, SUNY Health Science Center, Brooklyn, NY 11203, USA. lindahv@ufl.edu
Hermer-Vazquez
Raymond
R
Rybinnik
Igor
I
Greebel
Gennifer
G
Keller
Roni
R
Xu
Shaohua
S
Chapin
John K
JK
D000818:Animals; D003216:Conditioning, Operant / Q000502:physiology; D003463:Cues; D004558:Electric Stimulation; D005260:Female; D005502:Food; D006184:Habits; D007858:Learning / Q000502:physiology*; D008474:Medial Forebrain Bundle / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D009812:Odorants; D011597:Psychomotor Performance / Q000502:physiology; D051381:Rats; D020318:Rats, Long-Evans; D012201:Reward; D013028:Space Perception / Q000502:physiology