title: Relationship between mercury in blood and 24-h ambulatory blood pressure in Greenlanders and Danes.
abstract: BACKGROUND
  Intake of mercury with food items from sea mammals and fish has been suggested to be involved in cardiovascular disease, but the relationship between mercury in blood and 24-h ambulatory blood pressure (BP) has never been studied.
  
  
  METHODS
  We measured mercury in blood and 24-h BP in four groups of healthy subjects: group 1, Danes living in Denmark consuming European food; group 2, Greenlanders living in Denmark consuming European food; group 3, Greenlanders living in Greenland consuming European food; and group 4, Greenlanders living in Greenland consuming mainly traditional Greenlandic food.
  
  
  RESULTS
  Mercury in blood was highest in Greenlanders and increased when they lived in Greenland and consumed traditional Greenlandic food (group 1: 2.2 microg/L (median), group 2: 4.8 microg/L, group 3: 10.8 microg/L, and group 4: 24.9 microg/L). The 24-h BP was the same in all three groups of Greenlanders. However, 24-h diastolic BP was lower among Greenlanders than Danes (71 v 76 mm Hg, P < .000) and 24-h pulse pressure was higher (54 v 50 mm Hg, P < .000). Mercury in blood was significantly and positively correlated to pulse pressure (rho = 0.272, P < .01).
  
  
  CONCLUSIONS
  Pulse pressure was higher and diastolic BP was lower in Greenlanders than Danes. Pulse pressure increased with higher mercury content in the blood. Although genetic factors must be responsible to some extent for the difference in pulse pressure between Greenlanders and Danes, the present results seem to support the hypothesis that mercury intake from maritime food is involved in cardiovascular disease.
authors.affiliation: Department of Medical Research, Holstebro Hospital, Holstebro, Denmark. ebp@dadlnet.dk
authors.forename: Erling B
authors.initials: EB
authors.lastname: Pedersen
authors.forename: Marit E
authors.initials: ME
authors.lastname: Jørgensen
authors.forename: Michael B
authors.initials: MB
authors.lastname: Pedersen
authors.forename: Charlotte
authors.initials: C
authors.lastname: Siggaard
authors.forename: Tina B
authors.initials: TB
authors.lastname: Sørensen
authors.forename: Gert
authors.initials: G
authors.lastname: Mulvad
authors.forename: Jens C
authors.initials: JC
authors.lastname: Hansen
authors.forename: Gert
authors.initials: G
authors.lastname: Asmund
authors.forename: Henning
authors.initials: H
authors.lastname: Skjoldborg
mesh_terms: D000328:Adult; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D015992:Body Mass Index; D003718:Denmark; D005260:Female; D006116:Greenland; D006801:Humans; D008297:Male; D008628:Mercury / Q000097:blood*; D008875:Middle Aged; D012737:Sex Factors
chemical_list: D008628:Mercury