title: Long-term histological outcomes of injected autologous fat into human vocal folds after secondary laryngectomy.
abstract: OBJECTIVE
  To histologically evaluate the long-term outcomes of autologous fat grafts after injection laryngoplasty in the human larynx.
  
  
  METHODS
  We injected liposuctioned fat for vocal fold augmentation in patients with vocal fold paralysis. We suctioned autologous fat from the low abdomen with an 18-G disposable needle and a 20-mL disposable syringe under negative pressure. This is different from the conventional liposuction technique and avoids the use of special equipment. In this article, we report the histological evaluation of 2 patients (patient 1: 12 months, patient 2: 41 months) who required total laryngectomy after autologous fat injection into the vocal folds.
  
  
  RESULTS
  Histological examination revealed normal-appearing viable adipocytes with minimal inflammatory response in both patients.
  
  
  CONCLUSIONS
  Our liposuctioned autologous fat injection histologically offered long-term improvement in patients with impaired glottal closure from vocal fold paralysis.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Osaka General Medical Center, 3-1-56 Mandai-higashi, Sumiyoshi-ku, Osaka 558-8558, Japan. sasai@gh.pref.osaka.jp
authors.forename: Hisanori
authors.initials: H
authors.lastname: Sasai
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Muta
authors.forename: Junichi
authors.initials: J
authors.lastname: Yoshida
authors.forename: Ibuki
authors.initials: I
authors.lastname: Hayashi
authors.forename: Makoto
authors.initials: M
authors.lastname: Ogawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kubo
mesh_terms: D017667:Adipocytes / Q000473:pathology*; D000273:Adipose Tissue / Q000637:transplantation*; D006801:Humans; D007825:Laryngectomy; D007830:Larynx / Q000473:pathology; D015187:Lipectomy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014826:Vocal Cord Paralysis / Q000601:surgery*; D014827:Vocal Cords / Q000166:cytology / Q000473:pathology* / Q000601:surgery*