Study of the effects of mild hypothermia on cerebral PO2, PCO2 and pH and body temperature in patients with acute severe head injury.
OBJECTIVE
To study the effects of mild hypothermia on cerebral oxygen partial pressure, carbon dioxide partial pressure, pH and body temperature (PbrO2, PbrCO2, pHbr and BT) in patients with acute severe head injury.


METHODS
Thirty-eight patients with acute severe head injury were treated with mild hypothermia, meantime PbrO2, PbrCO2, pHbr and BT were monitored in order to study the changes of PbrO2, PbrCO2, pHbr and BT.


RESULTS
In patients with acute head injury, mild hypothermia obviously increased PbrO2, decreased PbrCO2 and CO2 accumulation and acidosis in brain tissue. BT was 1-1.5 deg. higher than rectal temperature (RT) after injury. The BT and RT were decreased when the patients were treated with mild hypothermia, but at the same time the difference between BT and RT was increased.


CONCLUSIONS
In patients with acute severe head injury the direct monitoring of PbrO2, PbrCO2, pHbr and BT was safe and reliable, and is helpful in estimating prognosis and mild hypothermia therapy.
Jia
Jun
J
Department of Neurosurgery, Shenzhen Longgang Central Hospital, Shenzhen 518116, China. jiajun69@yahoo.com.cn
Lin
Yuan-quan
YQ
Liu
Wen-feng
WF
Zhong
Tian-an
TA
Zhang
Jun
J
Ye
Yu
Y
Xu
Yi-qun
YQ
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001831:Body Temperature / Q000502:physiology; D001930:Brain Injuries / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D002245:Carbon Dioxide / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D015600:Glasgow Coma Scale; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007036:Hypothermia, Induced; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D010100:Oxygen / Q000097:blood*; D011336:Probability; D018570:Risk Assessment; D015996:Survival Rate; D016896:Treatment Outcome
D015415:Biomarkers; D002245:Carbon Dioxide; D010100:Oxygen