Correlation between apoptotic endothelial microparticles and serum interleukin-6 and C-reactive protein in healthy men.
Inflammation has been associated with increased cardiovascular risk, and endothelial cell (EC) apoptosis has been implicated in atherogenesis. The correlation between circulating concentrations of interleukin-6 (IL-6), C-reactive protein (CRP), and endothelial microparticles (EMPs) expressing an apoptotic (EMP31) or activation (EMP62E) phenotype in 20 middle-aged healthy men was investigated. IL-6 was significantly correlated with EMP31 (r = 0.6, p = 0.004), which persisted after adjusting for body mass index and CRP. CRP was significantly correlated with body mass index (r = 0.49, p = 0.02) but not with EMP31 or EMP62E. EC apoptosis is associated with IL-6 levels in men and might be partially responsible for the increased cardiovascular risk associated with subclinical inflammation.
Chirinos
Julio A
JA
Department of Medicine, Wallace H. Coulter Platelet Laboratory, University of Miami, Miami, Florida 33136, USA. jchirinos@med.miami.edu <jchirinos@med.miami.edu>
Zambrano
Juan P
JP
Virani
Salim S
SS
Jimenez
Joaquin J
JJ
Jy
Wenche
W
Ahn
Eugene
E
Horstman
Lawrence L
LL
Castellanos
Agustin
A
Myerburg
Robert J
RJ
Ahn
Yeon S
YS
D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012016:Reference Values
D015415:Biomarkers; D015815:Cell Adhesion Molecules; D015850:Interleukin-6; D002097:C-Reactive Protein