[Genetic analysis of osteoporosis susceptibility: future perspectives on genome wide analysis].
Genetic susceptibility of osteoporosis has been analyzed mainly via sib-pair analysis and association study on candidate genes, however these approaches might have substantial limitation. Recently proposed genome wide analysis of association using high density polymorphic markers has not been established on this field. Preferable phenotypes and suitable subjects have to be defined as well as for tag-SNP selection and the method of multi-step screening.
Ezura
Yoichi
Y
Tokyo Medical and Dental University, Institute of Medical Research.
Emi
Mitsuru
M
D020022:Genetic Predisposition to Disease; D005821:Genetic Techniques; D006801:Humans; D010024:Osteoporosis / Q000235:genetics*