Factors affecting protein release from microcapsule prepared by liposome in alginate.
A new type of drug delivery system that microcapsule was prepared by liposome in alginate on this paper, bovine serum albumin (BSA) as an model drug. Influences of liposomes composition and multivalent cations on morphology, enveloped rate, integrality and release in vitro from microcapsule were investigated. The results are showed that Ca2+ and Ba2+ made hydrogels form easier than Al3+ and particle size were uniform, circular, but microcapsule prepared by Al3+ was flat circular and easily adhere to each other. Particle size of all microcapsules was 200-300 microm after dryness, measured by vernier calliper. BSA enveloped rate prepared by PC/PG/Chol and Ba2+ was highest, 77.65%, and also correlative to concentration of lipid. At the other hand, Ba2+ microcapsule prepared by liposome in alginate has not an initial burst and have a good performance on delivering protein. Integrality of protein was not destroyed after encapsulated.
Dai
Chuanyun
C
Key Laboratory of Biomechanics and Tissue Engineering under the State Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, PR China.
Wang
Bochu
B
Zhao
Hongwei
H
Li
Biao
B
D000464:Alginates / Q000737:chemistry*; D000535:Aluminum / Q000737:chemistry; D001464:Barium / Q000737:chemistry; D002118:Calcium / Q000737:chemistry; D002214:Capsules; D004339:Drug Compounding; D016503:Drug Delivery Systems; D008081:Liposomes / Q000737:chemistry*; D010316:Particle Size; D010710:Phosphates / Q000737:chemistry; D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; D011506:Proteins / Q000008:administration & dosage* / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry
D000464:Alginates; D002214:Capsules; D008081:Liposomes; D010710:Phosphates; D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; D011506:Proteins; D001464:Barium; D012710:Serum Albumin, Bovine; D000535:Aluminum; D002118:Calcium