Application of bone morphogenetic proteins in spinal fusion.
We are now entering an exciting new era in spinal surgery where the inherent osteoinductive capacity of the body has been harnessed for bone formation for therapeutic purposes. Recombinant bone morphogenetic proteins have been extensively studied in both the pre-clinical and clinical arena for spinal fusion with considerable success. The challenges facing spine surgeons now is the development of site-specific carriers and optimal doses for these growth factors. This review highlights the recent advances in this regard.
Gupta
Munish C
MC
Department of Orthopaedic Surgery, University of California, Davis Medical Center, 4860 Y Street, Suite 3800, Sacramento, CA 95817, USA. munish.gupta@ucmc.ucdavis.edu
Khan
Safdar N
SN
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004337:Drug Carriers; D006801:Humans; D013123:Spinal Fusion
D019485:Bone Morphogenetic Proteins; D004337:Drug Carriers