title: Posterior capsule opacification in rabbit eyes implanted with 1-piece and 3-piece hydrophobic acrylic intraocular lenses.
abstract: OBJECTIVE
  To evaluate the outcome of posterior capsule opacification (PCO) after implantation in rabbit eyes of currently available 3-piece and 1-piece hydrophobic acrylic intraocular lenses (IOLs) with square optic edges.
  
  
  METHODS
  John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
  
  
  METHODS
  The 3-piece designs evaluated were the AR40e (Advanced Medical Optics Inc.) and the MA60AC (Alcon, Inc.); the 1-piece designs were the SA60AT and the SA30AT (Alcon, Inc.). Nine lenses of each type were implanted in a randomized manner by the same surgeon in 18 Dutch Belted pigmented rabbits. After a follow-up of 3 weeks, the rabbits were killed and analyses of the enucleated eyes were performed from the posterior or Miyake-Apple view. The intensity of central PCO, peripheral PCO, and Soemmering's ring formation was scored from 0 to 4. The area of Soemmering's ring formation was also scored from 0 to 4 based on the number of quadrants involved. Other parameters analyzed were capsulorhexis coverage of the IOL anterior surface, IOL centration, fixation, and presence of striae. Results from the posterior view were complemented by histopathologic evaluation of the eyes.
  
  
  RESULTS
  No statistically significant difference was found between the 4 groups of IOLs in the parameters analyzed from the posterior view. When cell ingrowth occurred with the 1-piece designs, causing peripheral and central PCO formation, it was more likely to start at the optic-haptic junctions, as observed during the clinical follow-up with slitlamp examination and confirmed by gross and histopathologic analyses of the enucleated eyes.
  
  
  CONCLUSIONS
  The square, truncated optic edge is the most important IOL design feature for PCO prevention. The optic-haptic junctions of the 1-piece designs appear to be sites where the barrier effect of the truncated optic edge is less effective.
authors.affiliation: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Liliana
authors.initials: L
authors.lastname: Werner
authors.forename: Nick
authors.initials: N
authors.lastname: Mamalis
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Izak
authors.forename: Suresh K
authors.initials: SK
authors.lastname: Pandey
authors.forename: Brandon L
authors.initials: BL
authors.lastname: Davis
authors.forename: Chistian D
authors.initials: CD
authors.lastname: Nilson
authors.forename: Christopher
authors.initials: C
authors.lastname: Weight
authors.forename: David J
authors.initials: DJ
authors.lastname: Apple
mesh_terms: D000180:Acrylic Resins; D000818:Animals; D001672:Biocompatible Materials; D002386:Cataract / Q000209:etiology* / Q000473:pathology; D004847:Epithelial Cells / Q000473:pathology; D057927:Hydrophobic and Hydrophilic Interactions; D007903:Lens Capsule, Crystalline / Q000473:pathology*; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular / Q000009:adverse effects*; D011183:Postoperative Complications; D011474:Prosthesis Design; D011817:Rabbits
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials