Cardiac troponin I: is it a marker to detect cardiotoxicity in children treated with doxorubicin?
Doxorubicin has been used in the the treatment of malignant tumors in children. Its use is limited by cardiotoxic effects beyond a cumulative dose of 450 mg/m2. To detect cardiotoxicity at an early stage and identify patients at risk for development of cardiotoxicity are matters of concern. Recently, cardiac troponin I (cTnI) has been reported to be useful for detecting minor myocardial damage. In the present study, we investigated whether cumulative doxorubicin-related myocardial cell damage can potentially increase cTnI levels above the expected values in 22 patients treated with cumulative doxorubicin doses of 120 to 450 mg/m2. Impaired cardiac functions were found in three patients by echocardiography, but serum CTnI levels were within the ranges expected in healthy individuals both in patients with cumulative doxorubicin doses > or = 400 mg/m2 and in patients with disturbed cardiac functions. We found no relationship between serum cTnI, cumulative dose of doxorubicin, and echocardiographical findings.
Köseoğlu
Vedat
V
Department of Pediatric Oncology, Gülhane Military Academy and Faculty of Medicine, Ankara, Turkey.
Berberoğlu
Semha
S
Karademir
Selmin
S
Kismet
Erol
E
Yurttutan
Neval
N
Demirkaya
Erkan
E
Sungur
Metin
M
Alehan
Dursun
D
D000293:Adolescent; D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood*; D001859:Bone Neoplasms / Q000188:drug therapy; D002648:Child; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D008297:Male; D012516:Osteosarcoma / Q000188:drug therapy*; D011237:Predictive Value of Tests; D019210:Troponin I / Q000097:blood*
D000903:Antibiotics, Antineoplastic; D015415:Biomarkers; D019210:Troponin I; D004317:Doxorubicin