Investigation of anti-inflammatory and antinociceptive activities of Lantana trifolia.
The anti-inflammatory activity of Lantana trifolia (Verbenaceae) was determined by carrageenan, serotonin and histamine-induced rat paw edema and the analgesic activity of this plant was studied by acetic acid-induced writhings and tail flick tests in mice. Lantana trifolia extracts (at 30 mg/kg) inhibited carrageenan and histamine-induced rat paw edema. Although the extracts did not produce any effect on acetic acid-induced writhings, they all develop a significant increase on tail flick antinociceptive index (doses varying between 1 and 30 mg/kg), indicating a spinal antinociceptive effect. These results provide support for the use of Lantana trifolia in relieving inflammatory pain.
Silva
Glauce N
GN
Departamento de Farmacologia Básica e Clínica/ICB, Centro de Ciências da Saude, Universidade Federal do Rio de Janeiro, Cidade Universitária, Brazil.
Martins
Fabíola R
FR
Matheus
Maria Eline
ME
Leitão
Suzana G
SG
Fernandes
Patricia D
PD
D019342:Acetic Acid; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D006358:Hot Temperature; D032410:Lantana / Q000737:chemistry* / Q000633:toxicity; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D011930:Reaction Time / Q000187:drug effects
D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D019342:Acetic Acid