The human parietal operculum. II. Stereotaxic maps and correlation with functional imaging results.
In this study we describe the localization of the cytoarchitectonic subdivisions of the human parietal operculum in stereotaxic space and relate these anatomically defined cortical areas to the location of the functionally defined secondary somatosensory cortex (SII cortex) using a meta-analysis of functional imaging results. The human parietal operculum consists of four distinct cytoarchitectonic areas (OP 1-4) as shown in the preceding publication. The 10 cytoarchitectonically examined brains were 3-D-reconstructed and spatially normalized to the T1-weighted single-subject template of the Montreal Neurological Institute (MNI). A probabilistic map was calculated for each area in this standard stereotaxic space. A cytoarchitectonic summary map of the four cortical areas on the human parietal operculum which combines these probabilistic maps was subsequently computed for the comparison with a meta-analysis of functional locations of SII. The meta-analysis used the results from 57 fMRI and PET studies and allowed the comparison of the functionally defined SII region to the cytoarchitectonic map of the parietal operculum. The functional localization of SII showed a good match to the cytoarchitectonically defined region. Therefore the cytoarchitectonic maps of OP 1-4 of the human parietal operculum can be interpreted as an anatomical correlate of the (functionally defined) human SII region. Our results also suggest that the SII foci reported in functional imaging studies may actually reflect activations in either of its architectonic subregions.
Eickhoff
Simon B
SB
Institute of Medicine, Research Center Jülich, 52425 Jülich, Germany.
Amunts
Katrin
K
Mohlberg
Hartmut
H
Zilles
Karl
K
D001931:Brain Mapping; D002102:Cadaver; D019054:Evoked Potentials, Motor / Q000502:physiology; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D066298:In Vitro Techniques; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009068:Movement / Q000502:physiology; D009415:Nerve Net / Q000166:cytology / Q000502:physiology; D009434:Neural Pathways / Q000166:cytology* / Q000502:physiology*; D009474:Neurons / Q000378:metabolism* / Q000502:physiology*; D010296:Parietal Lobe / Q000166:cytology; D013003:Somatosensory Cortex / Q000166:cytology* / Q000502:physiology*; D013223:Statistics as Topic; D013382:Subtraction Technique