[Central control of bone metabolism].
Leptin, a well-known adipokine regulating energy metabolism, inhibits bone formation via sympathetic nervous system. Recently, it was reported that adrenergic beta(2) receptor-deficient mice have high bone mass due to increased bone formation and decreased bone resorption. In addition, cocaine- and amphetamine-regulated transcript, an anorexigenic neuropeptide whose expression is regulated by leptin, has been shown to inhibit bone resorption. Thus, leptin regulates not only bone formation but bone resorption centrally.
Takeda
Shu
S
Department of Orthopedics, Center of Excellence Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University.
D000818:Animals; D001862:Bone Resorption / Q000503:physiopathology; D001842:Bone and Bones / Q000378:metabolism*; D001921:Brain / Q000502:physiology*; D006801:Humans; D020738:Leptin / Q000502:physiology; D051379:Mice; D013564:Sympathetic Nervous System / Q000502:physiology
D020738:Leptin