title: Descriptive study of chronic calcific pancreatitis in Sri Lanka.
abstract: OBJECTIVE
  To describe the potential risk factors, clinical features, biochemical and radiological features, and management of chronic calcific pancreatitis.
  
  
  METHODS
  Cross-sectional descriptive study.
  
  
  METHODS
  Tertiary care general hospital.
  
  
  METHODS
  Fifty patients with pancreatic calcification referred to the Colombo South Teaching Hospital, and 50 age-matched controls from healthy relatives or friends of the patients.
  
  
  METHODS
  Height and weight measurements, immunoreactive insulin levels and trypsin levels of duodenal aspirates were estimated. Plain abdominal xray and ultrasonography were performed.
  
  
  METHODS
  Endoscopic retrograde cholangiopancreaticography (ERCP) was attempted on all patients during which duodenal aspirates were collected. Success rates of ERCP and response to endotherapeutic procedures were recorded.
  
  
  RESULTS
  Twenty two of the 50 chronic calcific pancreatitis (CP) patients were diagnosed to have chronic alcoholic calcific pancreatitis (CACP). Mean age of the CACP patients was significantly higher than that of the chronic calcific pancreatitis of the tropics (CCPT) patients. Severe malnutrition (BMI < 20), frequent consumption of Manihot esculenta (manioc, cassava) and a high consumption of chilli or pepper were identified as possible risk factors for both alcoholic and non-alcoholic CP. Onset of diabetes occurred at a much younger age in the CCPT group than in the CACP group. Mean serum insulin was significantly higher in the CCPT group than in the CACP group and duodenal trypsin level was significantly lower in the CCPT than in CACP group.
  
  
  CONCLUSIONS
  Our results confirm the existence of both alcoholic (CACP) and non-alcoholic (CCPT) types of chronic calcific pancreatitis in Sri Lanka. A larger study is required to confirm the associated risk factors such as Manihot esculenta and foods with a high content of chilli or pepper.
authors.affiliation: Faculty of Medical Sciences, University of Sri Jayawardenepura, Nugegoda, Sri Lanka. thathya@stmail.lk
authors.forename: Mohan
authors.initials: M
authors.lastname: de Silva
authors.forename: Siva
authors.initials: S
authors.lastname: Selliah
authors.forename: Ira
authors.initials: I
authors.lastname: Thabrew
mesh_terms: D000328:Adult; D002114:Calcinosis / Q000175:diagnosis / Q000453:epidemiology*; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D005260:Female; D006784:Hospitals, Teaching; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000175:diagnosis / Q000453:epidemiology*; D019512:Pancreatitis, Alcoholic / Q000175:diagnosis / Q000453:epidemiology; D012307:Risk Factors; D013188:Sri Lanka / Q000453:epidemiology; D011795:Surveys and Questionnaires