title: Directed library of anilinogeranyl analogues of farnesyl diphosphate via mixed solid- and solution-phase synthesis.
abstract: [reaction: see text]. A directed library of anilinogeranyl diphosphate analogues of the isoprenoid farnesyl diphosphate has been prepared by solid-phase organic synthesis using a traceless linker strategy in moderate yield in three steps: reductive amination, bromination, and treatment with ((n-Bu)4N)3HP2O7.
authors.affiliation: Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40536-0084, USA.
authors.forename: Thangaiah
authors.initials: T
authors.lastname: Subramanian
authors.forename: Zhongwen
authors.initials: Z
authors.lastname: Wang
authors.forename: Jerry M
authors.initials: JM
authors.lastname: Troutman
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Andres
authors.forename: H Peter
authors.initials: HP
authors.lastname: Spielmann
mesh_terms: D000080462:Acyclic Monoterpenes; D000438:Alcohols / Q000138:chemical synthesis / Q000737:chemistry; D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D011106:Polyisoprenyl Phosphates / Q000138:chemical synthesis* / Q000737:chemistry; D012717:Sesquiterpenes; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000080462:Acyclic Monoterpenes; D000438:Alcohols; D000814:Aniline Compounds; D011106:Polyisoprenyl Phosphates; D012717:Sesquiterpenes; D013729:Terpenes; C004808:farnesyl pyrophosphate; C007836:geraniol