Xanthine oxidase inhibition for chronic heart failure: is allopurinol the next therapeutic advance in heart failure?
A substantial body of evidence has accumulated to suggest a role for the xanthine oxidase metabolic pathway in the pathophysiology of chronic heart failure and other cardiovascular diseases.
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D000493:Allopurinol / Q000627:therapeutic use*; D002303:Cardiac Output, Low / Q000188:drug therapy* / Q000201:enzymology; D002908:Chronic Disease; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D017079:Exercise Tolerance; D006801:Humans; D010101:Oxygen Consumption; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D000493:Allopurinol; D014969:Xanthine Oxidase