title: [A study on the expression of HSP70 and iNOS after human brain contusion].
abstract: OBJECTIVE
  To study the relationship between expression of HSP70, iNOS and traumatic brain contusion (TBI) in different posttraumatic intervals.
  
  
  METHODS
  35 samples of brain contusion were examined using immunohistochemecal staining to evaluate the expression of HSP70 and iNOS.
  
  
  RESULTS
  Maximal HSP70 expression was found at 0h after brain contusion. The intensity of HSP70 staining decreased remarkably to the minimum at 24h after TBI, then increased gradually. Expression of iNOS positive cells increased significantly and reached the maximum level 48h after TBI, then the expression decreased gradually from the 2nd day to the 11th day.
  
  
  CONCLUSIONS
  The changes of HSP70 and iNOS immunohistochemical staining can be used as a referential data for estimating time interval after human brain contusion.
authors.affiliation: School of Forensic Medicine, China Medical University, Shenyang 110001, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: De-wen
authors.initials: DW
authors.lastname: Wang
authors.forename: Xiao-dong
authors.initials: XD
authors.lastname: Sun
mesh_terms: D000328:Adult; D001253:Astrocytes / Q000378:metabolism; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D001930:Brain Injuries / Q000378:metabolism* / Q000473:pathology; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000096:biosynthesis*; D013194:Staining and Labeling; D013997:Time Factors
chemical_list: D018840:HSP70 Heat-Shock Proteins; D052247:Nitric Oxide Synthase Type II