title: [Long follow-up of breast cancer revealed by clustered microcalcifications without palpable mass].
abstract: OBJECTIVE
  In the past two decades, nonpalpable breast cancer incidence has greatly increased by routine screening mammography. Microcalcifications are the most frequent radiological feature.
  
  
  METHODS
  Between 1964 and 1994, 789 breast cancers revealed by clustered microcalcifications without palpable mass were treated at Institut Curie. Patients who had a past history of breast cancer or a contralateral cancer were eliminated like those with lobular carcinoma in situ. The definitive treatment was decided on the margins of the initial excision and the presence of microcalcifications on postoperative mammograms.
  
  
  RESULTS
  Mean follow-up of the patients was 77 months (9-358). The treatment was conservative in 49.5% and radical in 50.5%. Histologically, 43.5% of the lesions were intraductal carcinoma, 25.5% were microinvasive and 31% were infiltrating cancers. Five and ten years overall survival were 98% and 92.5% respectively, 50% of the patients died from their breast cancer. This survival was identical for intraductal, microinvasive and invasive carcinomas without lymph node metastasis, but was less favorable in patients with node metastasis. There were no survival differences for the two treatment modalities, although local recurrences were more frequent in the conservative one. The 5-year recurrence rate was 3.5% for intraductal subtype, 4.4% for microinvasive and 6% for invasive cancers. The difference was not statistically significant.
  
  
  CONCLUSIONS
  Under the impact of mammographic screening, sizable proportions of breast cancer patients are being seen in a totally nonpalpable state with either a very small invasive, microinvasive or intraductal breast cancer. These lesions have an excellent prognosis, and can benefit from less aggressive treatments. In the case of diffuse microcalcifications, where a radical treatment is indicated, skin sparing mastectomy can be easily done followed by immediate reconstructive surgery.
authors.affiliation: Service de Gynécologie-Obstétrique, Hôpital Saint-Joseph, Beyrouth, Liban. docgweh@terra.net.lb
authors.forename: Georges
authors.initials: G
authors.lastname: Wehbe
authors.forename: M
authors.initials: M
authors.lastname: Sepanda
authors.forename: Claude
authors.initials: C
authors.lastname: Nos
authors.forename: Marie-Claire
authors.initials: MC
authors.lastname: Falcou
authors.forename: Martine
authors.initials: M
authors.lastname: Meunier
authors.forename: Brigitte
authors.initials: B
authors.lastname: Zafrani
authors.forename: Alain
authors.initials: A
authors.lastname: Fourquet
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Durand
authors.forename: Joseph
authors.initials: J
authors.lastname: Azoury
authors.forename: Elie
authors.initials: E
authors.lastname: Massoud
authors.forename: Kristina
authors.initials: K
authors.lastname: Bentley Clough
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy; D002278:Carcinoma in Situ / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008327:Mammography; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D011879:Radiotherapy Dosage; D013997:Time Factors