title: Slitlamp biomicroscopy of the tear film of patients using topical Restasis and Refresh Endura.
abstract: We describe a technique in which slitlamp biomicroscopy is performed to evaluate eyes in patients using a topical dry-eye agent; ie, topical cyclosporine A ophthalmic emulsion 0.05% (Restasis) or glycerin 1%-polysorbate 80 1% (Refresh Endura). Both are delivered in an oil-emulsion formulation. We also describe a previously unreported physical finding in the tear film of these patients. The examination technique can help confirm patient compliance and the tear-film stability of the 2 agents.
authors.affiliation: Ophthalmic Consultants of Long Island, Rockville Centre, New York 11570, USA.
authors.forename: Renée
authors.initials: R
authors.lastname: Solomon
authors.forename: Henry D
authors.initials: HD
authors.lastname: Perry
authors.forename: Eric D
authors.initials: ED
authors.lastname: Donnenfeld
authors.forename: Herb E
authors.initials: HE
authors.lastname: Greenman
mesh_terms: D000287:Administration, Topical; D016572:Cyclosporine / Q000008:administration & dosage; D003941:Diagnostic Techniques, Ophthalmological; D004359:Drug Therapy, Combination; D015352:Dry Eye Syndromes / Q000188:drug therapy*; D004655:Emulsions; D005990:Glycerol / Q000008:administration & dosage; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000737:chemistry*; D008823:Micelles; D008853:Microscopy; D009883:Ophthalmic Solutions / Q000008:administration & dosage*; D010349:Patient Compliance; D011136:Polysorbates / Q000008:administration & dosage; D013666:Tears / Q000737:chemistry* / Q000378:metabolism
chemical_list: D004655:Emulsions; D008055:Lipids; D008823:Micelles; D009883:Ophthalmic Solutions; D011136:Polysorbates; D016572:Cyclosporine; D005990:Glycerol