title: Contribution to the radiological study of the eosinophilic granuloma of the mandible (unifocal granuloma due to Langerhans' cell histiocytosis).
abstract: OBJECTIVE
  The radiological diagnosis of osteolytic lesions of the mandible still constitutes a challenge in some pathological conditions in which the clinical data and the case history are relatively uniform and the radiological picture is lacking in any characteristics.
  
  
  METHODS
  We reviewed the conventional radiograms of six cases of Langerhans' cell histiocytosis (LCH) of the mandible examined over the last ten years. The X-ray examinations were performed in the lateral-oblique projection to allow a view of the horizontal portion of the mandible almost completely free of overlapping images of other bone structures.
  
  
  RESULTS
  We identified a series of radiological patterns for these reticulo-endotheliopathies capable of causing granuloma formed by polynuclear eosinophils, plasma cells, lymphocytes, and large mononuclear macrophages with granulopexic and phagocytic activity that proliferate in the bone tissue and can be identified as the Langerhans' cells of skin, mucosa, periodontal cavities and bone marrow. The granulomatous tissue penetrates the affected organ elements and, in its spread, it compresses, atrophies, and destroys the damaged tissue, replacing it. The alterations produced by Langerhans' cell histiocytic granuloma are most common in the skeletal system affecting, in order of frequency, the skull, the long bones of the limbs, the foot, the ribs and the spine. The oral mucosa is rarely involved.
  
  
  CONCLUSIONS
  The radiological investigation of unifocal Langerhans' cell histiocytic granuloma of the mandible is essential in the study of perimandibular swelling, although diagnosis is based on biopsy alone. In addition to digital or conventional radiography, other useful examinations are bone scintigraphy, Colour Doppler US, MR and CT, which enables a correct localisation necessary for planning the biopsy and treatment.
authors.affiliation: Dipartimento di Scienze Odontostomatologiche dell'Università di Bologna, Italy. gghigi@alma.unibo.it
authors.forename: Gino
authors.initials: G
authors.lastname: Ghigi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Pastremoli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bianchi
authors.forename: Paolo
authors.initials: P
authors.lastname: Pisi
authors.forename: Alfredo
authors.initials: A
authors.lastname: Pastremoli
mesh_terms: D000328:Adult; D000368:Aged; D002675:Child, Preschool; D004803:Eosinophilic Granuloma / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008336:Mandibular Diseases / Q000000981:diagnostic imaging*; D011859:Radiography; D012189:Retrospective Studies