title: Synthesis, characteristics and biological activity of pentacoordinated spirophosphoranes derived from amino acids.
abstract: The reactions of phosphorus trichloride with various amino acids afford the pentacoordinated spirophosphoranes. The reaction procedures were traced by (31)P NMR spectra techniques. A new crystal structure of alanine derivative was characterized, which is a slightly distorted TBP structure. Besides, this kind of spirophosphoranes are potent inhibitors to tyrosinase.
authors.affiliation: Department of Chemistry, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, China.
authors.forename: L
authors.initials: L
authors.lastname: Yu
authors.forename: Z
authors.initials: Z
authors.lastname: Liu
authors.forename: H
authors.initials: H
authors.lastname: Fang
authors.forename: Q L
authors.initials: QL
authors.lastname: Zeng
authors.forename: Y F
authors.initials: YF
authors.lastname: Zhao
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors; D010753:Phosphoranes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017553:Phosphorus Compounds / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D002712:Chlorides; D004791:Enzyme Inhibitors; D010753:Phosphoranes; D017553:Phosphorus Compounds; D014442:Monophenol Monooxygenase; C043693:phosphorus chloride