title: Physiological mechanisms of tumor-cell invasion and migration.
abstract: Recent advances in understanding the complex biology of the microenvironment that underlies tumor invasion and migration have revealed novel and promising therapeutic targets. Pharmacological blockade of intra- and extracellular signaling events that regulate migration and survival of multiple cell types may disrupt the host-tumor conspiracy that allows escape from normal developmental regulation.
authors.affiliation: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. gehod@mail.nih.gov
authors.forename: David H
authors.initials: DH
authors.lastname: Geho
authors.forename: Russell W
authors.initials: RW
authors.lastname: Bandle
authors.forename: Timothy
authors.initials: T
authors.lastname: Clair
authors.forename: Lance A
authors.initials: LA
authors.lastname: Liotta
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D006801:Humans; D009361:Neoplasm Invasiveness / Q000503:physiopathology*; D009369:Neoplasms / Q000473:pathology* / Q000503:physiopathology*