In vitro activity of linezolid against Staphylococcus aureus: a population study.
In our study, we aim to determine the existence of microorganisms that are heteroresistant to linezolid among Staphylococcus aureus clinical isolates in our setting between 1996 and 2002; during this period, linezolid was not used in clinical practice. There was no resistant subpopulation to 4 mg/l of linezolid in 99.4% of the strains. On the other hand, 16.46% of the strains exhibited resistant subpopulations to 4 microg/ml of vancomycin. However, the emergence of strains resistant to this drug has been described and the emergence of resistant strains should be monitored.
Rodríguez
Juan C
JC
Servicio de Microbiología, Hospital General Universitario de Elche, Universidad Miguel Hernández, Elche, Spain. micro_elx@gva.es
Ethlvarez
José M
JM
Escribano
Isabel
I
Royo
Gloria
G
D000081:Acetamides / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D000069349:Linezolid; D023303:Oxazolidinones / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification
D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid