[The mechanotransduction mechanism of how osteoblasts respond to mechanical stimulation].
The stress environment regulates the factors of growth, resorption and remolding in bone tissue. Mechanical stimulation at cell physical level affects the physiological activity of osteoblasts, including proliferation, ALP activity and osteocalcin production. Mechanotransduction is a procedure which transduces the biophysical force into biochemical responses. It is also the basis of many physiological functions. The early response genes (c-fos, c-jun), the second message systems (Ca2+, NO, cAMP) and the mechano-sensitive cation channel are involved in the mechanotransduction course when osteoblasts respond to the mechanical stimulation.
Wang
Yuanliang
Y
Key Lab. of Biomechanics & Tissue Engineering under the State Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China. wyl@cqu.edu.cn
Tang
Liling
L
Wang
Jianhua
J
Cai
Shaoxi
S
D001696:Biomechanical Phenomena; D002118:Calcium / Q000502:physiology; D006801:Humans; D040542:Mechanotransduction, Cellular; D010006:Osteoblasts / Q000502:physiology*; D015675:Osteocalcin / Q000096:biosynthesis; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis / Q000235:genetics; D016755:Proto-Oncogene Proteins c-jun / Q000096:biosynthesis / Q000235:genetics; D015398:Signal Transduction; D013314:Stress, Mechanical
D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun; D015675:Osteocalcin; D002118:Calcium