Vitamins C and E in the latency period in women with preterm premature rupture of membranes.
OBJECTIVE
To determine whether supplementation with vitamins C and E after preterm premature rupture of membranes (PPROM) is associated with an increased latency period.


METHODS
In this double-blind, randomized, controlled trial, 60 women with singleton pregnancies of 26 to 34 weeks' duration and PPROM were randomly assigned to vitamin C (500 mg/day) and vitamin E (400 IU/day) or placebo until delivery. All women received 2 doses of betamethasone in the first 24 h after admission as well as broad-spectrum antibiotic prophylaxis.


RESULTS
Important demographic, as well as clinical characteristics such as number of cases of chorioamnionitis, early neonatal sepsis, and respiratory distress syndrome, were similar in the 2 groups. A statically significant difference in the mean+/-S.D. number of days of latency was found between the groups (10.5+/-5.2 days vs. 3.5+/-4.0 days (P = 0.03).


CONCLUSIONS
Vitamins C and E supplementation of after PPROM is associated with a longer latency before delivery.
Borna
S
S
Department of Perinatology, Tehran University of Medical Sciences, Tehran, Iran.
Borna
H
H
Daneshbodie
B
B
D000328:Adult; D001205:Ascorbic Acid / Q000008:administration & dosage*; D002821:Chorioamnionitis / Q000517:prevention & control*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000503:physiopathology*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D013997:Time Factors; D016896:Treatment Outcome; D014810:Vitamin E / Q000008:administration & dosage*
D014810:Vitamin E; D001205:Ascorbic Acid