Plasmodium falciparum: genetic diversity of C-terminal region of MSP-1 in isolates from Indian sub-continent.
Malaria parasites exhibit sequence diversity for a number of stage specific antigens. Several studies have proved that merozoite surface protein-1 (MSP-1) is an effective target eliciting a protective immune response. The MSP-1(42) region comprising two EGF-like domains is involved in generating protective immune response in humans and other experimental animals. Searching for point mutations in this region is essential in view of vaccine development. We have investigated the sequence variations in Plasmodium falciparum MSP-1 carboxy terminal region in field isolates from different regions in India. Our study reveals the presence of eight variant types of MSP-1(19) in the Indian sub-continent, which comprise of E-TSR-L, Q-TSR-L, E-TSG-L, Q-KNG-L, Q-KNG-F, E-KNG-L, E-KNG-F, and E-KYG-F. The last named allele is a novel variant being reported for the first time.
Vijay Kumar
S
S
Department of Biological Sciences, Birla Institute of Technology and Science, Pilani, Rajasthan, India.
Ranjan
Sarita
S
Saxena
Vishal
V
Rajesh
Vidya
V
Roy
S K
SK
Kochar
Dhanpat
D
Ranjan
Akash
A
Das
Ashis
A
D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D016054:DNA, Protozoan / Q000737:chemistry; D014644:Genetic Variation; D006801:Humans; D007194:India; D016778:Malaria, Falciparum / Q000469:parasitology*; D020066:Merozoite Surface Protein 1 / Q000737:chemistry / Q000235:genetics*; D008969:Molecular Sequence Data; D010963:Plasmodium falciparum / Q000235:genetics*; D017354:Point Mutation
D016054:DNA, Protozoan; D020066:Merozoite Surface Protein 1