Atopic dermatitis: beyond the itch that rashes.
The prevalence of atopic dermatitis is increasing, and more than 50% of children with atopic dermatitis go on to develop asthma and allergies. A better understanding of the underlying immune abnormalities of this complex chronic relapsing skin disease is needed. Although the optimal treatment approach remains to be defined, several recent studies suggest a rationale for using topical calcineurin inhibitors as early intervention and adding topical corticosteroids as rescue therapy if needed.
Boguniewicz
Mark
M
Division of Pediatric Allergy-Immunology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, J 310, Denver, CO 80206, USA.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001427:Bacterial Toxins / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000276:immunology*; D005076:Exanthema / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D009824:Ointments / Q000627:therapeutic use; D011537:Pruritus / Q000188:drug therapy / Q000276:immunology*; D016559:Tacrolimus / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D001427:Bacterial Toxins; D009824:Ointments; D016559:Tacrolimus