title: Computed tomography colonography: automated diameter and volume measurement of colonic polyps compared with a manual technique--in vitro study.
abstract: OBJECTIVE
  To investigate inter- and intraobserver agreement of automated measurement of polyp diameter in vitro.
  
  
  METHODS
  Two phantoms ("QRM" and "Whiting") containing simulated polyps of known diameter and volume were scanned using 16-detector row computed tomography. Two observers estimated polyp diameter using 3 methods: software calipers ("manual"), freehand boundary identification ("semiautomatic"), and automated software segmentation ("fully automatic").
  
  
  RESULTS
  Intraobserver 95% limits of agreement for diameter were narrowest for the fully automatic method (QRM span: 0.39 mm, 0.48 mm; Whiting span: 0.24 mm, 0 mm). Manual estimates were approximately 10 times wider (QRM span: 3.57 mm, 3.21 mm; Whiting span: 3.2 mm, 2.02 mm). Volume estimates were narrowest for the fully automatic method (span: 24.2 mm, 24.1 mm vs. 97.9 mm, 102.9 mm for semiautomatic measurement). Interobserver agreement for diameter was narrowest for the fully automatic method (QRM span: 0.12 mm, Whiting span: 0.16 mm), with the manual method approximately 18 times wider (QRM span: 2.87 mm, Whiting span: 2.18 mm).
  
  
  CONCLUSIONS
  Fully automated measurement of polyp diameter and volume is technically feasible and results in superior inter- and intraobserver agreement.
authors.affiliation: Intestinal Imaging Centre, St. Mark's Hospital, Northwick Park, London, United Kingdom.
authors.forename: David
authors.initials: D
authors.lastname: Burling
authors.forename: Steve
authors.initials: S
authors.lastname: Halligan
authors.forename: Mary E
authors.initials: ME
authors.lastname: Roddie
authors.forename: Justine
authors.initials: J
authors.lastname: McQuillan
authors.forename: Lesley
authors.initials: L
authors.lastname: Honeyfield
authors.forename: Hamdan
authors.initials: H
authors.lastname: Amin
authors.forename: Jamshid
authors.initials: J
authors.lastname: Dehmeshki
authors.forename: Stuart A
authors.initials: SA
authors.lastname: Taylor
authors.forename: Elizabeth G
authors.initials: EG
authors.lastname: McFarland
mesh_terms: D003111:Colonic Polyps / Q000000981:diagnostic imaging*; D023881:Colonography, Computed Tomographic / Q000295:instrumentation; D004867:Equipment Design; D019047:Phantoms, Imaging