title: Treatment of multidrug-resistant tuberculosis during pregnancy: long-term follow-up of 6 children with intrauterine exposure to second-line agents.
abstract: Treatment of gestational multidrug-resistant tuberculosis (MDR-TB) is controversial. We describe follow-up of 6 children exposed to second-line antituberculous agents in utero. Each child (average age, 3.7 years) underwent comprehensive clinical evaluation. One child had MDR-TB diagnosed. There was no evidence of significant late-presentation toxicity among the children. The results suggest that aggressive management of gestational MDR-TB may benefit both mother and child.
authors.affiliation: Department of Social Medicine and Health Inequalities, Brigham and Women's Hospital, Boston, MA 02120, USA. pdrobac@partners.org
authors.forename: Peter C
authors.initials: PC
authors.lastname: Drobac
authors.forename: Hernan
authors.initials: H
authors.lastname: del Castillo
authors.forename: Annika
authors.initials: A
authors.lastname: Sweetland
authors.forename: Genaro
authors.initials: G
authors.lastname: Anca
authors.forename: J Keith
authors.initials: JK
authors.lastname: Joseph
authors.forename: Jennifer
authors.initials: J
authors.lastname: Furin
authors.forename: Sonya
authors.initials: S
authors.lastname: Shin
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D024901:Drug Resistance, Multiple, Bacterial; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D008297:Male; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced*; D013997:Time Factors; D014376:Tuberculosis / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents