title: Syndecan-1 and E-cadherin expression in differentiated type of early gastric cancer.
abstract: OBJECTIVE
  To elucidate the role and alterations of syndecan-1 and E-cadherin expression in different cellular phenotypes of differentiated-type gastric cancers (DGCs).
  
  
  METHODS
  A total of 120 DGCs at an early stage, and their adjacent mucosa, were studied both by immunohistochemistry. Syndecan-1 and E-cadherin were assessed by immunohistochemical staining with anti-syndecan-1 and anti-E-cadherin antibodies, respectively. Based on immunohistochemistry, DGCs and their surrounding mucosa were divided into four types: gastric type (G-type), ordinary type (O-type), complete-intestinal type (CI-type), and null type (N-type).
  
  
  RESULTS
  Syndecan-1 expression was significantly lower in G-type cancers (29.4%) than in O-type (79.6%) and CI-type cancers (90%) (P<0.05, respectively), but E-cadherin did not show this result. In addition, syndecan-1 expression was significantly reduced in DGCs comprised partly of poorly differentiated adenocarcinoma or signet-ring cell carcinoma, compared to DGCs demonstrating papillary and/or tubular adenocarcinoma (P<0.05). G-type intestinal metaplasia (IM) surrounding the tumors was observed in 23.8% of G-type, 4.9% of O-type, and 6.7% of CI-type cancers (P<0.05; G-type vs O-type). Reduction of syndecan-1 expression was significant in G-type IM (25%) compared to non-G-type IM (75%; P<0.05).
  
  
  CONCLUSIONS
  Loss of syndecan-1 plays a role in the growth of G-type cancers of DGCs at an early stage, and the reduction of syndecan-1 expression in IM surrounding the tumors may influence the growth of G-type cancer.
authors.affiliation: Department of Digestive Disease, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province, China.
authors.forename: Mei-Fang
authors.initials: MF
authors.lastname: Huang
authors.forename: You-Qing
authors.initials: YQ
authors.lastname: Zhu
authors.forename: Zhi-Fen
authors.initials: ZF
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Xiao
authors.forename: Xin
authors.initials: X
authors.lastname: Huang
authors.forename: Yong-Yan
authors.initials: YY
authors.lastname: Xiong
authors.forename: Gui-Fang
authors.initials: GF
authors.lastname: Yang
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology*; D000328:Adult; D015820:Cadherins / Q000378:metabolism*; D002291:Carcinoma, Papillary / Q000378:metabolism / Q000473:pathology; D018279:Carcinoma, Signet Ring Cell / Q000378:metabolism / Q000473:pathology; D002454:Cell Differentiation; D042241:Early Diagnosis; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008875:Middle Aged; D011509:Proteoglycans / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology*; D053668:Syndecan-1; D053667:Syndecans
chemical_list: D015820:Cadherins; D008562:Membrane Glycoproteins; D011509:Proteoglycans; C508241:SDC1 protein, human; D053668:Syndecan-1; D053667:Syndecans