title: Variability in the description of morphologic and contrast enhancement characteristics of breast lesions on magnetic resonance imaging.
abstract: OBJECTIVE
  The objective of this study was to evaluate the interobserver variability in reporting descriptive kinetic and morphologic enhancement features at breast magnetic resonance imaging.
  
  
  METHODS
  Four observers evaluated 103 lesions, 49 malignant and 54 benign, proven by histopathology. They used standardized terminology with the following characteristics: "early enhancement kinetics" and "late enhancement kinetics" in curves from both reader-determined and preset regions of interest (ROIs), "enhancement pattern," "shape," "margin," "internal enhancement," and a final assessment score. Agreement was calculated using the kappa statistic. Differences in agreement were calculated using Fisher exact test.
  
  
  RESULTS
  kappa was 0.27 for both early and late enhancement; preset ROIs improved kappa to 0.47 and 0.67, respectively (odds ratios, 1.7 and 4.5). kappa was 0.45 for pattern, 0.42 for shape, 0.26 for margin, 0.25 for internal enhancement, and 0.28 for final assessment.
  
  
  CONCLUSIONS
  There was considerable variability in the use of most generally accepted terms. The preparation of ROIs was a major source of variability in the interpretation of enhancement curves.
authors.affiliation: Radboud University Nijmegen Medical Centre, Department of Radiology, The Netherlands. m.stoutjesdijk@rad.umcn.nl
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Stoutjesdijk
authors.forename: Jurgen J
authors.initials: JJ
authors.lastname: Fütterer
authors.forename: Carla
authors.initials: C
authors.lastname: Boetes
authors.forename: Lya E
authors.initials: LE
authors.lastname: van Die
authors.forename: Gerrit
authors.initials: G
authors.lastname: Jager
authors.forename: Jelle O
authors.initials: JO
authors.lastname: Barentsz
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis*; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D015588:Observer Variation; D012680:Sensitivity and Specificity; D009626:Terminology as Topic