[Current status of the prognostic value of molecular markers in patients with colorectal cancer and the prediction of response to adjuvant therapy].
Colorectal cancer is one of the best studied of all malignant diseases in terms of genetics and/or molecular prognostic factors. These factors, and relationships with prognosis, may have important implications especially in the design of surgical and adjuvant chemo-radiotherapy options. However, the true prognostic significance of all known factors has yet to be realised. We have reviewed the literature with specific focus on the role of molecular markers involved in prognosis and the prediction of response to adjuvant treatment.
Fernández-Cebrián
Jose M
JM
Unidad de Cirugía General y Aparato Digestivo, Fundación Hospital Alcorcón, C/Budapest 1, Alcorcón, 28922 Madrid, Spain. jmfernandez@fhalcoron.es
Vorwald Kuborn
Peter
P
Pardo de Lama
Mar
M
Sanjuanbenito Dehesa
Alfonso
A
Nevado Santos
Manuel
M
Pacheco Martínez
Pedro A
PA
Fernández-Escudero
Beatriz
B
D017209:Apoptosis / Q000235:genetics; D014408:Biomarkers, Tumor / Q000032:analysis; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D009154:Mutation; D009857:Oncogenes; D011379:Prognosis
D014408:Biomarkers, Tumor