Neurotoxicity of polychlorinated biphenyls (PCBs) by disturbance of thyroid hormone-regulated genes.
PCBs are known as neurotoxic compounds. Part of this neurotoxicity could be due to an alteration of the expression of TH-regulated genes in brain. To identify such genes, brain protein extracts of hypo- and hyperthyroid as well as PCB-treated embryos were compared by fluorescent 2D-DIGE. In total, we observed 109 differentially expressed proteins, of which 17 differed with both PCB and hypo- or hyperthyroid treatment. It was found that the interaction of PCBs with the expression of TH-regulated genes is congener-specific and that both hyperthyroidism- and hypothyroidism-related effects occur.
Roelens
S A
SA
Laboratory of Comparative Endocrinology, Katholieke Universiteit Leuven, Belgium. simon.roelens@bio.kuleuven.ac.be
Beck
V
V
Aerts
G
G
Clerens
S
S
Vanden Bergh
G
G
Arckens
L
L
Darras
V M
VM
van der Geyten
S
S
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002642:Chick Embryo; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D013963:Thyroid Hormones / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology
D013963:Thyroid Hormones; D011078:Polychlorinated Biphenyls