title: [Disorder of liver functions in a schizophrenic patient after long-term risperidone treatment--case report].
abstract: We present a 51-year old man with an 18-year history of chronic paranoid schizophrenia. The last four years he was treated only with risperidone at a dose of 3 mg per day. He was admitted to hospital due to a psychotic decompensation. Jaundice and skin pruritus were also observed at admission. Laboratory tests revealed elevated liver enzymes. Cholestatic and viral hepatitis were excluded. Risperidone was changed to other antipsychotic drugs. After 7 weeks of treatment the patient was discharged with significant improvement of his mental condition. The liver function test results returned to normal values except for the slightly increased total bilirubin level. Regular liver monitoring was suggested. In this case liver dysfunction was possibly correlated with long-term risperidone therapy.
authors.affiliation: Katedrŕ i Klinikŕ Psychiatrii AM we Wrocławiu.
authors.forename: Jacek
authors.initials: J
authors.lastname: Radzik
authors.forename: Bartosz
authors.initials: B
authors.lastname: Grotthus
authors.forename: Jerzy
authors.initials: J
authors.lastname: Leszek
mesh_terms: D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D002908:Chronic Disease; D006801:Humans; D007565:Jaundice / Q000139:chemically induced; D008099:Liver / Q000187:drug effects; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011537:Pruritus / Q000139:chemically induced; D018967:Risperidone / Q000008:administration & dosage / Q000009:adverse effects*; D012563:Schizophrenia, Paranoid / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D014150:Antipsychotic Agents; D018967:Risperidone