title: Chronic treatment with haloperidol induces deficits in working memory and feedback effects of interval timing.
abstract: Normal participants (n=5) having no experience with antipsychotic drugs and medicated participants (n=5) with clinical experience with chronic low doses of haloperidol (3-10 mg/day for 2-4 months) in the treatment of neuroses were evaluated for the effects of inter-trial interval (ITI) feedback on a discrete-trials peak-interval timing procedure. Feedback was presented during the ITI in the form of a histogram showing the distribution of the responses participants made on the previous trial plotted on a relative time scale. As feedback concerning the accuracy and precision of a reproduced duration (e.g., 7- and 14-s visual signals) became more remote in time, reproduced intervals gradually lengthened in duration. This rightward horizontal shift in peak time increased as a function of the probability of feedback and was enhanced by chronic treatment with haloperidol in a manner that was proportional to the duration of the signal. Our data suggest a gradual change in the underlying representation of the signal duration as a function of the remoteness of ITI feedback that is dependent upon both changes in working memory and the speed of the internal clock used to time durations in the seconds-to-minutes range.
authors.affiliation: Department of Psychology, University of Michigan, United States.
authors.forename: Cindy
authors.initials: C
authors.lastname: Lustig
authors.forename: Warren H
authors.initials: WH
authors.lastname: Meck
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001683:Biological Clocks / Q000187:drug effects; D004334:Drug Administration Schedule; D030141:Feedback, Psychological / Q000187:drug effects*; D005260:Female; D006220:Haloperidol / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects*; D009497:Neurotic Disorders / Q000188:drug therapy; D012016:Reference Values; D013998:Time Perception / Q000187:drug effects*
chemical_list: D014150:Antipsychotic Agents; D006220:Haloperidol