title: A comparative study of 2D and 3D ultrasonography for evaluation of solid breast masses.
abstract: OBJECTIVE
  To compare image quality and diagnostic accuracy of 2D with 3D ultrasonography in solid breast masses.
  
  
  METHODS
  To rate image quality, two radiologists compared lesion contrast and characterization of 507 solid breast masses in 2D and 3D ultrasonography and then graded the 3D imaging in 3-point scale. To characterize the masses, the same radiologists rated the examination for clarity of margin, posterior acoustic feature, and clustered microcalcifications within a mass. In addition, the masses were assigned BI-RADS categories as proposed by the American College of Radiology, criteria using just ultrasonographic features. In the 202 pathologically confirmed cases, sensitivity, specificity, positive predictive value, negative predictive value, and false negative rate for diagnosis of breast cancer in 2D and 3D ultrasonography were assessed. Image quality and diagnostic accuracy were further evaluated according to the size of the masses.
  
  
  RESULTS
  Two observers rated 3D imaging superior to 2D imaging in terms of lesion contrast and characterization of the masses. Especially, superiority of 3D ultrasonography in terms of image quality was increasing in more than 10 mm sized masses. However, diagnostic accuracy including sensitivity, specificity, positive predictive value, negative predictive value, and false negative rate for diagnosis of breast cancer of 3D imaging was not different from 2D imaging.
  
  
  CONCLUSIONS
  In spite of superior image quality on 3D ultrasonography, it does not provide additional benefits to diagnostic accuracy for diagnosis of breast cancer.
authors.affiliation: Department of Diagnostic Radiology, Korea University Hospital, Seoul, Korea.
authors.forename: Kyu Ran
authors.initials: KR
authors.lastname: Cho
authors.forename: Bo Kyoung
authors.initials: BK
authors.lastname: Seo
authors.forename: June Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Etta D
authors.initials: ED
authors.lastname: Pisano
authors.forename: Bo Kyung
authors.initials: BK
authors.lastname: Je
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Eun Jeong
authors.initials: EJ
authors.lastname: Choi
authors.forename: Kyoo Byung
authors.initials: KB
authors.lastname: Chung
authors.forename: Yu
authors.initials: Y
authors.lastname: Whan Oh
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D015588:Observer Variation; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D016217:Ultrasonography, Mammary / Q000379:methods*