Completion of the full-length genome sequence of Menangle virus: characterisation of the polymerase gene and genomic 5' trailer region.
Menangle virus (MenV), isolated in 1997 from stillborn piglets during an outbreak of reproductive disease at a large commercial piggery, is the only new paramyxovirus to be identified in Australia since Hendra virus in 1994. Following partial characterisation of the MenV genome, we previously showed that MenV is a novel member of the genus Rubulavirus. Here we report the characterisation of the large (L) polymerase gene and the adjacent 5' trailer region of MenV, which completes the full-length genome sequence of this novel paramyxovirus (15,516 nucleotides), and thereby confirm its taxonomic position within the family Paramyxoviridae.
Bowden
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CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Vict., Australia.
Boyle
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DB
D000595:Amino Acid Sequence; D000818:Animals; D001315:Australia; D001483:Base Sequence; D004279:DNA, Viral / Q000235:genetics; D004259:DNA-Directed DNA Polymerase / Q000235:genetics; D012321:DNA-Directed RNA Polymerases / Q000235:genetics; D005814:Genes, Viral; D016679:Genome, Viral; D008969:Molecular Sequence Data; D010802:Phylogeny; D019213:Rubulavirus / Q000145:classification / Q000201:enzymology / Q000235:genetics*; D019351:Rubulavirus Infections / Q000662:veterinary / Q000821:virology; D017386:Sequence Homology, Amino Acid; D034421:Sus scrofa / Q000821:virology*; D013552:Swine; D013553:Swine Diseases / Q000821:virology; D014764:Viral Proteins / Q000235:genetics
D004279:DNA, Viral; D014764:Viral Proteins; D012321:DNA-Directed RNA Polymerases; D004259:DNA-Directed DNA Polymerase