Neuroglial activation in Niemann-Pick Type C mice is suppressed by intracerebral transplantation of bone marrow-derived mesenchymal stem cells.
Glial activation is thought to play a key role in pathogenesis of neurodegenerative disorders. Here we show that direct transplantation of bone marrow-derived mesenchymal stem cells (BM-MSC) results in alleviation of inflammatory responses associated with the cerebellum of Niemann-Pick disease Type C (NP-C) model mice. Immunohistochemical examinations using glial fibrillary acidic protein (GFAP) and F4/80 antibodies revealed that BM-MSC transplantation reduced significantly both of astrocytic and microglial activations in the cerebellum of NP-C mice. Expression of macrophage colony stimulating factor (M-CSF), a microglial activator, was also considerably down-regulated by the BM-MSC transplantation. These findings suggest that BM-MSC transplantation may have potential for a therapeutic role in the treatment of NP-C and other neurodegenerative brain disorders.
Bae
Jae-sung
JS
College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea.
Furuya
Shigeki
S
Ahn
So-jeo
SJ
Yi
Seong-joon
SJ
Hirabayashi
Yoshio
Y
Jin
Hee Kyung
HK
D000818:Animals; D001921:Brain / Q000473:pathology*; D004195:Disease Models, Animal; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D007150:Immunohistochemistry; D008262:Macrophage Activation / Q000502:physiology*; D045164:Mesenchymal Stem Cell Transplantation; D051379:Mice; D008822:Mice, Transgenic; D009457:Neuroglia / Q000378:metabolism*; D009542:Niemann-Pick Diseases / Q000473:pathology / Q000628:therapy*
D005904:Glial Fibrillary Acidic Protein