title: Usefulness of procalcitonin in the early detection of infection after thoracic surgery.
abstract: OBJECTIVE
  The twofold aim of this prospective clinical study was to assess the accuracy of procalcitonin as a marker of postoperative infection after thoracic surgery and to compare it with C-reactive protein.
  
  
  METHODS
  Procalcitonin and C-reactive protein concentrations, clinical symptoms of infection and systemic inflammation were recorded preoperatively and 5 days postoperatively in 157 patients undergoing the following procedures: 52 wedge resections, 28 pneumonectomies and 77 lobectomies (or bilobectomies). Patients were classified as non-infected or infected according to predefined criteria.
  
  
  RESULTS
  In non-infected patients (n=132), procalcitonin peaked on day 1 and C-reactive protein, on day 2. The procalcitonin value was significantly higher in patients having undergone a pneumonectomy (0.73+/-0.78 versus 0.54+/-0.25 ng/mL for lobectomy and 0.50+/-0.35 ng/mL for wedge resection; P=0.04). The mean value of procalcitonin was significantly higher in patients with postoperative infection (n=25) than in those with no postoperative infection (3.6+/-5.5 versus 0.63+/-0.62 ng/mL; P=0.0001). The onset of infection most frequently occurred on postoperative day 2 (43% of patients); maximum procalcitonin and C-reactive protein concentrations most frequently appeared on postoperative day 1 (56% of patients) and day 2 (63% of patients), respectively. The best cutoff value for detection of infection with procalcitonin was 1 ng/mL and with C-reactive protein, 100mg/L. Comparing the area under the Receiver Operating Characteristic curves, procalcitonin was better than C-reactive protein for detecting postoperative infection (0.92 versus 0.66; P<0.0001).
  
  
  CONCLUSIONS
  Procalcitonin can be used as a reliable diagnostic parameter to detect and to monitor infectious complications in the postoperative period after thoracic surgery, especially in patients felt to be at higher risk (SIRS). It provides more information about the course of the disease than C-reactive protein does, and can be detected before the occurrence of clinical infection.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Jean-Minjoz Hospital, Boulevard Fleming, 25000, Besançon, France. pierre-emmanuel.falcoz@wanadoo.fr
authors.forename: Pierre-Emmanuel
authors.initials: PE
authors.lastname: Falcoz
authors.forename: Fréderic
authors.initials: F
authors.lastname: Laluc
authors.forename: Marie-Madeleine
authors.initials: MM
authors.lastname: Toubin
authors.forename: Marc
authors.initials: M
authors.lastname: Puyraveau
authors.forename: François
authors.initials: F
authors.lastname: Clement
authors.forename: Mariette
authors.initials: M
authors.lastname: Mercier
authors.forename: Sidney
authors.initials: S
authors.lastname: Chocron
authors.forename: Joseph-Philippe
authors.initials: JP
authors.lastname: Etievent
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000097:blood* / Q000601:surgery*; D008175:Lung Neoplasms / Q000097:blood / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011498:Protein Precursors / Q000097:blood*; D012680:Sensitivity and Specificity; D013530:Surgical Wound Infection / Q000097:blood / Q000175:diagnosis*
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide