CCL3L1 dose and HIV-1 susceptibility.
Several genetic factors influence HIV-1 susceptibility or AIDS disease progression. A recent study reported on what could be a particularly important genetic determinant for HIV-1 susceptibility and disease progression: copy number of a chemokine gene termed CCL3L1. Individuals with low copy numbers of the gene, relative to their ethnic background, were associated with markedly enhanced HIV-1/AIDS susceptibility. These findings define an important new genetic determinant of HIV-1 susceptibility and further emphasize the importance of the chemokine system, either as elements that inhibit HIV-1 infection or that modulate antiviral immune responses.
Mackay
Charles R
CR
Arthritis and Inflammation Research Program, The Garvan Institute of Medical Research, 384 Victoria Street, Sydney, NSW 2010, Australia. c.mackay@garvan.org.au
D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics*; D019742:Chemokines, CC / Q000235:genetics*; D018628:Gene Dosage; D020022:Genetic Predisposition to Disease; D015497:HIV-1; D006801:Humans
C492767:CCL3L1 protein, human; D019742:Chemokines, CC