Clofazimine as elective treatment for granulomatous cheilitis.
Cheilitis granulomatosa (CG) is a rare, idiopathic inflammatory disorder that usually affects young adults and clinically is characterized by diffuse, non-tender, soft to firm swelling of one or both lips. A variant of granulomatous cheilitis is Melkersson-Rosenthal syndrome when associated with facial paralysis and furrowed tongue. Several treatments have been used with variable success. We report 3 cases of GC treated with oral clofazimine 100 to 200 mg daily for 3 to 6 months obtaining regression of lesions in all treated cases. Hyperpigmentation and elevation of liver enzymes were observed as side effects.
Fdez-Freire
Lourdes Rodríguez
LR
Department of Dermatology, Virgen del Rocio University Hospital, Seville, Spain.
Serrano Gotarredona
Amalia
A
Bernabeu Wittel
Jose
J
Pulpillo Ruiz
Agueda
A
Cabrera
Rocío
R
Navarrete Ortega
Manuel
M
Conejo-Mir
Julián
J
D000328:Adult; D000368:Aged; D002991:Clofazimine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008556:Melkersson-Rosenthal Syndrome / Q000188:drug therapy* / Q000473:pathology
D002991:Clofazimine