Long-lived radiopharmaceuticals: dispensing from multidose vials.
We report the use of broth simulation as a means of validating the practice of sub-dispensing from stock vials of long-lived sterile radiopharmaceuticals. 'Matched' vials of nutrient broth accompanied the stock vials of long-lived sterile radiopharmaceuticals during their time in use and were subject to the same handling and storage procedures. At the end of the life of each radiopharmaceutical stock vial, the matching broth residue was sent for incubation and reporting. The results to date have yielded no reports of microbial contamination in any of the simulated broths (0 in 256).
Murray
Tom
T
Radionuclide Dispensary, Western Infirmary, Glasgow, UK. tom.murray@northglasgow.scot.nhs.uk
Elliott
Alex T
AT
Hilditch
Thomas E
TE
D001419:Bacteria / Q000302:isolation & purification*; D004340:Drug Contamination / Q000517:prevention & control*; D004349:Drug Packaging; D004355:Drug Stability; D004356:Drug Storage / Q000379:methods*; D011785:Quality Assurance, Health Care / Q000379:methods*; D019275:Radiopharmaceuticals / Q000032:analysis*
D019275:Radiopharmaceuticals