Immobilization and release of etophylin from hydrogels, based on polyacrylic acid and macrodiisocyanates.
Hydrogels, based on polyacrylic acid and various macrodiisocyanates that contain polyethylene glycol, polypropylene glycol or polytetramethylene glycol in the main chain are synthesized. The obtained hydrogels are studied as possible polymer carriers of drug substances. Etophylin was applied as a model drug. It is exposed that the etophylin release rate from the hydrogel depends on the way of drug comprise in the polymer net, from its density from the chemical nature of the crosslinking agent and from the pH of the environment. The carried out studies let us to conclude that the obtained hydrogels are possible materials as drug carriers.
Dimitrov
M
M
Medical University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Sofia - Bulgaria.
Doseva
V
V
Shenkov
S
S
Lambov
N
N
Baranovski
V
V
D000179:Acrylates; D003432:Cross-Linking Reagents; D020100:Hydrogels; D006863:Hydrogen-Ion Concentration; D017953:Isocyanates; D007700:Kinetics; D011687:Purines / Q000008:administration & dosage / Q000737:chemistry*; D012995:Solubility
D000179:Acrylates; D003432:Cross-Linking Reagents; D020100:Hydrogels; D017953:Isocyanates; D011687:Purines; C501556:etophylin