title: Dengue hemorrhagic fever and acute hepatitis: a case report.
abstract: Dengue fever is the world's most important viral hemorrhagic fever disease, the most geographically wide-spread of the arthropod-born viruses, and it causes a wide clinical spectrum of disease. We report a case of dengue hemorrhagic fever complicated by acute hepatitis. The initial picture of classical dengue fever was followed by painful liver enlargement, vomiting, hematemesis, epistaxis and diarrhea. Severe liver injury was detected by laboratory investigation, according to a syndromic surveillance protocol, expressed in a self-limiting pattern and the patient had a complete recovery. The serological tests for hepatitis and yellow fever viruses were negative. MAC-ELISA for dengue was positive.
authors.affiliation: Tropical Medicine Foundation of Amazonas, Laboratory of Arbovirology, University of the State of Amazonas, Av. Pedro Texeira 25, Planalto, 69040-000 Manaus, Amazonas, Brazil. mpmourao@uol.com.br
authors.forename: Maria Paula Gomes
authors.initials: MP
authors.lastname: Mourão
authors.forename: Marcus Vinícius Guimarães de
authors.initials: MV
authors.lastname: Lacerda
authors.forename: Michele de Souza
authors.initials: Mde S
authors.lastname: Bastos
authors.forename: Bernardino Cláudio de
authors.initials: BC
authors.lastname: Albuquerque
authors.forename: Wilson Duarte
authors.initials: WD
authors.lastname: Alecrim
mesh_terms: D000208:Acute Disease; D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006505:Hepatitis / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008297:Male; D019595:Severe Dengue / Q000150:complications* / Q000175:diagnosis; D012720:Severity of Illness Index