Usefulness of plasma brain-type natriuretic peptide level to differentiate left ventricular diastolic dysfunction from preserved diastolic function in patients with systolic dysfunction.
The extent of left ventricular (LV) diastolic dysfunction is related to the finding that some patients with cardiomegaly due to LV systolic dysfunction have good exercise tolerance, although others have limited tolerance. A brain-type natriuretic peptide level of >/=104 pg/ml reliably enables the detection of relatively worse LV diastolic function in patients with systolic dysfunction, and this value may provide clinically useful information for the management of patients with cardiomegaly.
Goto
Toshihiko
T
Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Ohte
Nobuyuki
N
Miyabe
Hiromichi
H
Sakata
Seiichiro
S
Asada
Kaoru
K
Mukai
Seiji
S
Hayano
Junichiro
J
Kimura
Genjiro
G
D015415:Biomarkers / Q000097:blood*; D006332:Cardiomegaly / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D013599:Systole; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis*
D015415:Biomarkers; D020097:Natriuretic Peptide, Brain