title: Reward dependence is related to norepinephrine transporter T-182C gene polymorphism in a Korean population.
abstract: It is well established that approximately 50% of the variance in personality traits is genetic. The goal of this study was to investigate a relationship between personality traits and the T-182C polymorphism in the norepinephrine transporter gene. The participants included 115 healthy adults with no history of psychiatric disorders and other physical illness during the past 6 months. All participants were tested with the Temperament and Character Inventory and genotyped norepinephrine transporter gene polymorphism. Differences on the Temperament and Character Inventory dimensions among three groups were examined with one-way analysis of variance. Our study suggests that the norepinephrine transporter T-182C gene polymorphism is associated with reward dependence in Koreans, but the small number of study participants and their sex and age heterogeneity limits generalization of our results. Further studies are necessary with a larger number of homogeneous participants to confirm whether the norepinephrine transporter gene is related to personality traits.
authors.affiliation: Department of Neuropsychiatry, Hangang Sacred Heart Hospital, Hallym University Medical Center, Seoul, Korea.
authors.forename: Byung-Joo
authors.initials: BJ
authors.lastname: Ham
authors.forename: Myoung-Jin
authors.initials: MJ
authors.lastname: Choi
authors.forename: Heon-Jeong
authors.initials: HJ
authors.lastname: Lee
authors.forename: Rhee-Hun
authors.initials: RH
authors.lastname: Kang
authors.forename: Min-Soo
authors.initials: MS
authors.lastname: Lee
mesh_terms: D000328:Adult; D003858:Dependency, Psychological; D005260:Female; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D050484:Norepinephrine Plasma Membrane Transport Proteins; D020641:Polymorphism, Single Nucleotide; D012201:Reward; D027981:Symporters / Q000235:genetics*
chemical_list: D050484:Norepinephrine Plasma Membrane Transport Proteins; C493227:SLC6A2 protein, human; D027981:Symporters