Laminin stimulates and guides axonal outgrowth via growth cone myosin II activity.
Guidance cues and signal transduction mechanisms acting at the nerve growth cone are fairly well understood, but the intracellular mechanisms operating to change the direction of axon outgrowth remain unknown. We now show that growth cones integrate myosin II-dependent contraction for rapid, coordinated turning at borders of laminin stripes in response to signals from laminin-activated integrin receptors; in the absence of myosin II activity, outgrowth continues across the borders.
Turney
Stephen G
SG
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, Missouri 63110, USA.
Bridgman
Paul C
PC
D008841:Actin Cytoskeleton / Q000378:metabolism; D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002450:Cell Communication / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D002478:Cells, Cultured; D003463:Cues; D020439:Growth Cones / Q000378:metabolism* / Q000648:ultrastructure; D016023:Integrins / Q000378:metabolism; D020407:Internet; D007797:Laminin / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D024462:Myosin Type II / Q000378:metabolism*; D009414:Nerve Growth Factors / Q000378:metabolism; D009420:Nervous System / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D016501:Neurites / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D014741:Video Recording
D016023:Integrins; D007797:Laminin; D009414:Nerve Growth Factors; D024462:Myosin Type II