Epigenetic silencing mechanisms in budding yeast and fruit fly: different paths, same destinations.
Transcriptional silencing in budding yeast and fruit fly is mediated by fundamentally unrelated proteins that assemble very different chromatin structures. Surprisingly, the repressive mechanisms evolved from these very different materials have similar features, including an epigenetic mode of inheritance and a block to transcription based on interference with the assembly or function of the promoter complex rather than with the binding of gene-specific activators.
Pirrotta
Vincenzo
V
Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA. pirrotta@biology.rutgers.edu
Gross
David S
DS
D000818:Animals; D042002:Chromatin Assembly and Disassembly / Q000502:physiology; D004247:DNA / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics* / Q000502:physiology; D044127:Epigenesis, Genetic / Q000502:physiology*; D020868:Gene Silencing / Q000502:physiology*; D006657:Histones / Q000378:metabolism; D009030:Mosaicism; D020218:Response Elements; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000502:physiology
D004268:DNA-Binding Proteins; D006657:Histones; D004247:DNA