2-Methoxy-6-oxo-1,4,5,6-tetrahydropyridine-3-carbonitriles: versatile starting materials for the synthesis of libraries with diverse heterocyclic scaffolds.
Heterocyclic demonstration libraries for agrochemical screening were prepared from the common intermediates 2-methoxy-6-oxo-1,4,5,6-tetrahydropyridine-3-carbonitriles (1), using standard solution-phase techniques. A total of 18 screening libraries were prepared in good to excellent yields. Several members of these libraries were active in the first level of agrochemical screening, especially in the fungicide screen.
Martínez-Teipel
Blanca
B
Grup d'Enginyeria Molecular, Institut Químic de Sarrià, Universitat Ramon Llull, Via Augusta, 390, E-08017 Barcelona, Spain.
Teixidó
Jordi
J
Pascual
Rosalia
R
Mora
Marta
M
Pujolà
Josep
J
Fujimoto
Ted
T
Borrell
José I
JI
Michelotti
Enrique L
EL
D002626:Chemistry, Pharmaceutical; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D004353:Drug Evaluation, Preclinical; D005659:Fungicides, Industrial / Q000032:analysis / Q000494:pharmacology; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D008970:Molecular Weight; D009570:Nitriles / Q000737:chemistry*; D011728:Pyridones / Q000737:chemistry*; D013237:Stereoisomerism
D005659:Fungicides, Industrial; D006571:Heterocyclic Compounds; D009570:Nitriles; D011728:Pyridones