Neonatal lupus erythematosus presenting with cholestatic hepatitis: a case report and review of the literature.
Neonatal lupus erythematosus (NLE) is a disease primarily characterized by cardiac and/or cutaneous involvement. Hepatic, hematological, neurological and pulmonary involvement are rare manifestations and normally considered as mild and transient complications. But recent studies have shown more frequent hepatic involvement in NLE. We report a two month-old male infant, born to a clinically asymptomatic mother, presenting with significant hepatic involvement and annular, erythematous plaques with hyperkeratotic borders at the eyebrow region and anterior surface of trunk. Both the infant and his mother were positive for anti-Ro (SS-A) and anti-La (SS-B).
Erbey
Fatih
F
Department of Pediatrics, Cukurova University Faculty of Medicine, Adana, Turkey.
Cuhaci
Abdullah
A
Incecik
Faruk
F
Noyan
Aytül
A
Altintaş
Derya Ufuk
DU
Tuncer
Ilhan
I
Duran
Figen
F
D000410:Alanine Transaminase / Q000097:blood; D000974:Antibodies, Antinuclear / Q000097:blood; D001663:Bilirubin / Q000097:blood; D002780:Cholestasis, Intrahepatic / Q000209:etiology*; D043384:Glutamyl Aminopeptidase / Q000097:blood; D006801:Humans; D017488:Hyperkeratosis, Epidermolytic / Q000097:blood; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D008297:Male; D011379:Prognosis; D013256:Steroids / Q000008:administration & dosage / Q000627:therapeutic use; D016896:Treatment Outcome
D000974:Antibodies, Antinuclear; D013256:Steroids; D000410:Alanine Transaminase; D043384:Glutamyl Aminopeptidase; D001663:Bilirubin