AC electrospray biomaterials synthesis.
A rapid, viable and safe fabrication method for biomaterials synthesis is reported using high-frequency AC electrospraying. We demonstrate its potential for polymeric nanoparticle fabrication, drug encapsulation in mono-dispersed micron-sized biodegradable polymer shells and the synthesis of 1microm biodegradable fibers with adjustable pore sizes as bioscaffolds for tissue/orthopaedic engineering and wound care therapy. The absence of charge in the ejected drops and fibers facilitates pulmonary drug delivery, polymer encapsulation and minimizes protein/DNA denaturing or compound ionization.
Yeo
Leslie Y
LY
Department of Chemical & Biomolecular Engineering, Center for Microfluidics & Medical Diagnostics, University of Notre Dame, Notre Dame, IN 46556, USA.
Gagnon
Zachary
Z
Chang
Hsueh-Chia
HC
D001672:Biocompatible Materials / Q000032:analysis / Q000138:chemical synthesis*; D003460:Crystallization / Q000379:methods*; D004337:Drug Carriers / Q000138:chemical synthesis*; D016503:Drug Delivery Systems / Q000379:methods; D004563:Electrochemistry / Q000379:methods*; D004574:Electromagnetic Fields; D007477:Ions; D049329:Nanostructures / Q000032:analysis / Q000737:chemistry*; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods*; D010316:Particle Size; D011108:Polymers / Q000032:analysis / Q000138:chemical synthesis*
D001672:Biocompatible Materials; D004337:Drug Carriers; D007477:Ions; D011108:Polymers