[Connection between uveal melanoma and dysplastic naevus syndrome].
The dysplastic naevus syndrome increases the risk of cutaneous (RR: 4.36; CI: 1.84-10.36) as well as uveal melanoma (RR: 4.22; CI: 1.81-9.84). A significantly higher occurrence rate of conjunctival naevi (3.2% vs. 0%; p=0.029), choroidal naevi (5.2% vs. 0.7%; p=0.023) and iris freckles (17.1% vs. 5.6%; p=0.002) could be detected in the dysplastic naevus syndrome patients compared to subjects in the control group. The presence of cutaneous dysplastic naevi in uveal melanoma patients increases the risk of the prognostically worse--epitheloid or mixed--forms of uveal melanoma (RR: 5.97%; CI: 1.61-22.14), compared to patients without cutaneous atypical naevi.
Hammer
Helga
H
Szegedi Tudomány Egyetem AOK, Szemészeti Klinika, 6720 Szeged, Korányi fasor 10-12, Hungary.
Tóth-Molnár
Edit
E
Oláh
Judit
J
Dobozy
Attila
A
D000328:Adult; D016022:Case-Control Studies; D016001:Confidence Intervals; D004273:DNA, Neoplasm / Q000032:analysis*; D004416:Dysplastic Nevus Syndrome / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D007498:Iris; D008297:Male; D008545:Melanoma / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D016017:Odds Ratio; D010857:Pigment Epithelium of Eye; D018570:Risk Assessment; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D014604:Uveal Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology
D004273:DNA, Neoplasm