The design and implementation of the immune epitope database and analysis resource.
Epitopes are defined as parts of antigens interacting with receptors of the immune system. Knowledge about their intrinsic structure and how they affect the immune response is required to continue development of techniques that detect, monitor, and fight diseases. Their scientific importance is reflected in the vast amount of epitope-related information gathered, ranging from interactions between epitopes and major histocompatibility complex molecules determined by X-ray crystallography to clinical studies analyzing correlates of protection for epitope based vaccines. Our goal is to provide a central resource capable of capturing this information, allowing users to access and connect realms of knowledge that are currently separated and difficult to access. Here, we portray a new initiative, "The Immune Epitope Database and Analysis Resource." We describe how we plan to capture, structure, and store this information, what query interfaces we will make available to the public, and what additional predictive and analytical tools we will provide.
Peters
Bjoern
B
La Jolla Institute of Allergy and Immunology, 3030 Bunker Hill Street, Suite 326, San Diego, CA 92109, USA.
Sidney
John
J
Bourne
Phil
P
Bui
Huynh-Hoa
HH
Buus
Soeren
S
Doh
Grace
G
Fleri
Ward
W
Kronenberg
Mitch
M
Kubo
Ralph
R
Lund
Ole
O
Nemazee
David
D
Ponomarenko
Julia V
JV
Sathiamurthy
Muthu
M
Schoenberger
Stephen P
SP
Stewart
Scott
S
Surko
Pamela
P
Way
Scott
S
Wilson
Steve
S
Sette
Alessandro
A
D000818:Animals; D016208:Databases, Factual; D000939:Epitopes; D006801:Humans; D016056:Immunodominant Epitopes; D020407:Internet; D017434:Protein Structure, Tertiary
D000939:Epitopes; D016056:Immunodominant Epitopes