title: Early onset neonatal meningitis in Australia and New Zealand, 1992-2002.
abstract: OBJECTIVE
  To study the epidemiology of early onset neonatal bacterial meningitis (EONBM) in Australasia.
  
  
  METHODS
  Prospective surveillance study, 1992-2002, in 20 neonatal units in Australia and New Zealand. EONBM was defined as meningitis occurring within 48 hours of delivery.
  
  
  RESULTS
  There were 852 babies with early onset sepsis, of whom 78 (9.2%) had EONBM. The incidence of early onset group B streptococcal meningitis fell significantly from a peak of 0.24/1000 live births in 1993 to 0.03/1000 in 2002 (p trend = 0.002). There was no significant change over time in the incidence of Escherichia coli meningitis. The rate of EONBM in very low birthweight babies was 1.09/1000 compared with the rate in all infants of 0.11/1000. The overall rate of EONBM was 0.41/1000 in 1992 and 0.06 in 2001, but this trend was not significant (p trend = 0.07). Case-fatality rates for EONBM did not change significantly with time. Birth weight <1500 g (odds ratio (OR) 7.2 (95% confidence interval (CI) 4.8 to 10.9)) and Gram negative bacillary meningitis (OR 3.3 (95% CI 2.2 to 4.9)) were significant risk factors for mortality. Sixty two percent of the 129 babies who died from early onset sepsis or suspected sepsis did not have a lumbar puncture performed.
  
  
  CONCLUSIONS
  The incidence of early onset group B streptococcal meningitis has fallen, probably because of maternal intrapartum antibiotic prophylaxis, without a corresponding change in E. coli meningitis. Gram negative bacillary meningitis still carries a worse prognosis than meningitis with a Gram positive organism.
authors.affiliation: Department of Microbiology, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, NSW 2145, Australia.
authors.forename: M
authors.initials: M
authors.lastname: May
authors.forename: A J
authors.initials: AJ
authors.lastname: Daley
authors.forename: S
authors.initials: S
authors.lastname: Donath
authors.forename: D
authors.initials: D
authors.lastname: Isaacs
mesh_terms: D017668:Age of Onset; D019072:Antibiotic Prophylaxis; D001315:Australia / Q000453:epidemiology; D016470:Bacteremia / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D016920:Meningitis, Bacterial / Q000453:epidemiology*; D020814:Meningitis, Escherichia coli / Q000453:epidemiology; D009520:New Zealand / Q000453:epidemiology; D011379:Prognosis; D011446:Prospective Studies; D013129:Spinal Puncture / Q000706:statistics & numerical data; D013290:Streptococcal Infections / Q000453:epidemiology; D013292:Streptococcus agalactiae