An A/G polymorphism of core 2 branching enzyme gene is associated with prostate cancer.
The expression of core 2 beta1,6-N-acetylglucosaminyltransferase-1 (C2GnT) is associated with development and progression of malignancy. Sequence analysis showed that the codon 152 of C2GnT has a polymorphism having GTT encoding valine or ATT encoding isoleucine. By examining the polymorphism in prostate cancer and benign prostatic hyperplasia patients, we found that the C2GnT G allele was more frequently observed in the prostate cancer group (p=0.015) than the control group. Men with the GG genotype had a 3.60-fold increased risk of prostate cancer, and men with the AG genotype had a 1.58-fold increased risk of prostate cancer compared with those with the AA genotype. The G allele was found to have a gene dosage effect for prostate cancer risk. No such risk was associated for benign prostatic hyperplasia. These results demonstrate that C2GnT A/G polymorphism is associated with the susceptibility to prostate cancer in a Japanese population.
Wang
Lizhong
L
Department of Urology, Akita University School of Medicine, Akita, Japan.
Mitoma
Junya
J
Tsuchiya
Norihiko
N
Narita
Shintaro
S
Horikawa
Yohei
Y
Habuchi
Tomonori
T
Imai
Atsushi
A
Ishimura
Hirofumi
H
Ohyama
Chikara
C
Fukuda
Minoru
M
D015061:1,4-alpha-Glucan Branching Enzyme / Q000235:genetics*; D000368:Aged; D001483:Base Sequence; D016022:Case-Control Studies; D017931:DNA Primers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000201:enzymology*
D017931:DNA Primers; D015061:1,4-alpha-Glucan Branching Enzyme