Penicillin G acylase catalyzed Markovnikov addition of allopurinol to vinyl ester.
A new enzymatic process is reported, in which penicillin G acylase from Escherichia coli displays a promiscuous activity in catalyzing the Markovnikov addition of allopurinol to vinyl ester.
Wu
Wei-Bo
WB
Department of Chemistry, Zhejiang University, Hangzhou, 310027, People's Republic of China.
Wang
Na
N
Xu
Jian-Ming
JM
Wu
Qi
Q
Lin
Xian-Fu
XF
D000493:Allopurinol / Q000737:chemistry*; D002384:Catalysis; D004926:Escherichia coli / Q000201:enzymology; D004952:Esters / Q000737:chemistry*; D015394:Molecular Structure; D010399:Penicillin Amidase / Q000737:chemistry*; D011687:Purines / Q000138:chemical synthesis*; D013997:Time Factors; D014753:Vinyl Compounds / Q000737:chemistry*
D004952:Esters; D011687:Purines; D014753:Vinyl Compounds; D000493:Allopurinol; D010399:Penicillin Amidase