New approach to 3-oxo-4-aza-5alpha-androst-1-ene-17beta-(N-tert-butylcarboxamide).
We describe the synthesis of 3-oxo-4-aza-5alpha-androst-1-ene-17beta-(N-tert-butylcarboxamide) (finasteride) from 4-androstene-3,17-dione (AD) in seven steps in an overall yield of 18.6% via oxidation, ammoniumation, dehydration, and dehydrogenation.
Jiang
Zhong-Xing
ZX
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei, PR China. ioc@whu.edu.cn
Ye
Jing-Quan
JQ
Jiang
Li
L
Zhao
Ying-Sheng
YS
D058891:5-alpha Reductase Inhibitors; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D018120:Finasteride / Q000138:chemical synthesis* / Q000737:chemistry
D058891:5-alpha Reductase Inhibitors; D004791:Enzyme Inhibitors; D018120:Finasteride