title: Pathogenesis of levodopa-induced dyskinesia: focus on D1 and D3 dopamine receptors.
abstract: Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa therapy for Parkinson's disease. Taking advantage of a monkey brain bank constituted to study the pathophysiology of levodopa-induced dyskinesia, we here report the changes affecting D1, D2 and D3 dopamine receptors within the striatum of four experimental groups of non-human primates: normal, parkinsonian, parkinsonian treated with levodopa without or with dyskinesia. We also report the possible role of arrestin and G protein-coupled receptor kinases.
authors.affiliation: Basal Gang, Laboratoire de Physiologie et Physiopathologie de la Signalisation Cellulaire, CNRS UMR 5543, Université Victor Segalen-Bordeaux 2, France.
authors.forename: C
authors.initials: C
authors.lastname: Guigoni
authors.forename: I
authors.initials: I
authors.lastname: Aubert
authors.forename: Q
authors.initials: Q
authors.lastname: Li
authors.forename: V V
authors.initials: VV
authors.lastname: Gurevich
authors.forename: J L
authors.initials: JL
authors.lastname: Benovic
authors.forename: S
authors.initials: S
authors.lastname: Ferry
authors.forename: U
authors.initials: U
authors.lastname: Mach
authors.forename: H
authors.initials: H
authors.lastname: Stark
authors.forename: L
authors.initials: L
authors.lastname: Leriche
authors.forename: K
authors.initials: K
authors.lastname: Håkansson
authors.forename: Bernard H
authors.initials: BH
authors.lastname: Bioulac
authors.forename: Christian E
authors.initials: CE
authors.lastname: Gross
authors.forename: Pierre
authors.initials: P
authors.lastname: Sokoloff
authors.forename: Gilberto
authors.initials: G
authors.lastname: Fisone
authors.forename: E V
authors.initials: EV
authors.lastname: Gurevich
authors.forename: Bertrand
authors.initials: B
authors.lastname: Bloch
authors.forename: Erwan
authors.initials: E
authors.lastname: Bezard
mesh_terms: D000978:Antiparkinson Agents / Q000009:adverse effects*; D004409:Dyskinesia, Drug-Induced / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D007980:Levodopa / Q000009:adverse effects*; D010300:Parkinson Disease / Q000188:drug therapy* / Q000503:physiopathology; D017447:Receptors, Dopamine D1 / Q000502:physiology*; D017448:Receptors, Dopamine D2 / Q000502:physiology*; D050637:Receptors, Dopamine D3
chemical_list: D000978:Antiparkinson Agents; C493593:DRD3 protein, human; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D007980:Levodopa