Enhanced reactivity to vasopressin in rat basilar arteries during vasospasm after subarachnoid hemorrhage.
Subarachnoid hemorrhage increases the plasma level of vasopressin, a well-known vasoconstrictor. We examined the sensitivity to vasopressin in rat basilar artery after subarachnoid hemorrhage using a rat subarachnoid hemorrhage model. Vasospasm was observed 1-2 days after subarachnoid hemorrhage induction, and the contractile response to vasopressin in rat basilar arteries was assessed. The concentration-response curve for vasopressin in subarachnoid hemorrhage (1 day) rats shifted leftward compared with that of control rats. The concentration-response curve for vasopressin V(1) receptor agonist also shifted leftward and upward compared with that of control rats. The concentration-response curve for vasopressin was inhibited not by vasopressin V(2) receptor antagonist but by vasopressin V(1) receptor antagonist. Thus, it was demonstrated that the vasoconstricting effect of vasopressin was significantly enhanced in the vasospasm phase after subarachnoid hemorrhage.
Nishihashi
Tsuyoshi
T
Pharmacology Division, RI Center, Kyoto University, Japan.
Trandafir
Cristina C
CC
Wang
Aimin
A
Ji
Xu
X
Kurahashi
Kazuyoshi
K
D000818:Animals; D065092:Antidiuretic Hormone Receptor Antagonists; D001488:Basilar Artery / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D009025:Morpholines / Q000494:pharmacology; D010121:Oxytocin / Q000031:analogs & derivatives* / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017483:Receptors, Vasopressin / Q000819:agonists; D013141:Spiro Compounds / Q000494:pharmacology; D013345:Subarachnoid Hemorrhage / Q000150:complications*; D013997:Time Factors; D014661:Vasoconstriction / Q000187:drug effects*; D014662:Vasoconstrictor Agents / Q000494:pharmacology*; D014667:Vasopressins / Q000097:blood / Q000494:pharmacology*; D020301:Vasospasm, Intracranial / Q000209:etiology / Q000503:physiopathology*
D065092:Antidiuretic Hormone Receptor Antagonists; D009025:Morpholines; D017483:Receptors, Vasopressin; D013141:Spiro Compounds; D014662:Vasoconstrictor Agents; D014667:Vasopressins; C047063:oxytocin, Phe(2)-Orn(8)-; D010121:Oxytocin; D011189:Potassium Chloride; C103281:satavaptan