title: Synthesis and antifungal activity of 2/3-arylthio- and 2,3-bis(arylthio)-5-hydroxy-/5-methoxy-1,4-naphthoquinones.
abstract: 2/3-Arylthio- and 2,3-bis(arylthio)-5-hydroxy-/5-methoxy-1,4-naphthoquinones 5-9 were synthesized and tested for in vitro antifungal activity against Candida species and Aspergillus niger. The synthesized compounds 5-9 generally showed good activities against Candida albicans and C. tropicalis. The results suggest that the 1,4-naphthoquinones 5-9 would be potent antifungal agents.
authors.affiliation: College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, South Korea. ckryu@mm.ewha.ac.kr
authors.forename: Chung-Kyu
authors.initials: CK
authors.lastname: Ryu
authors.forename: Ju-Yeon
authors.initials: JY
authors.lastname: Shim
authors.forename: Mi Jin
authors.initials: MJ
authors.lastname: Chae
authors.forename: Ik Hwa
authors.initials: IH
authors.lastname: Choi
authors.forename: Ja-Young
authors.initials: JY
authors.lastname: Han
authors.forename: Ok-Jai
authors.initials: OJ
authors.lastname: Jung
authors.forename: Jung Yoon
authors.initials: JY
authors.lastname: Lee
authors.forename: Seong Hee
authors.initials: SH
authors.lastname: Jeong
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001234:Aspergillus niger / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D045744:Cell Line, Tumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared
chemical_list: D000935:Antifungal Agents; D009285:Naphthoquinones