title: An experimental study of apico-aortic valved conduit (AAVC) for surgical treatment of aortic stenosis in dogs.
abstract: A new valved conduit was developed using a canine aortic valve. The bioprosthetic valve was fixed with glutaraldehyde and epoxy compound (Denacol-EX313/810). A vascular graft composed of ultra-fine polyester fiber (10 mm in diameter, 200 mm in length) was used. Four dogs underwent apico-aortic valved conduit (AAVC) implantation and aortic banding (bypass group, BG), while another 4 dogs underwent aortic banding without AAVC implantation (control group, CG). Cardiac catheterization and angiocardiography were performed for assessment of hemodynamics 2 weeks and 6 months after surgery. Left ventricular systolic pressure, left ventricular end-diastolic pressure and the left ventricular-aortic pressure gradient differed significantly (P<0.01) between the BG and CG dogs. Left ventricular angiocardiography showed patency of the valved conduit in all the BG dogs. Echocardiography was performed before and 2, 4 and 6 months after surgery, and showed that while pressure overload caused concentric myocardial hypertrophy in the CG dogs, the left ventricle dilated eccentrically in the BG dogs. Furthermore, relief of left ventricular pressure overload by AAVC was maintained.
authors.affiliation: Department of Veterinary Surgery, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Japan.
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Hirao
authors.forename: Tomoki
authors.initials: T
authors.lastname: Inoue
authors.forename: Katsuichiro
authors.initials: K
authors.lastname: Hoshi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Shimamura
authors.forename: Miki
authors.initials: M
authors.lastname: Shimizu
authors.forename: Ryou
authors.initials: R
authors.lastname: Tanaka
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Takashima
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Mori
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Noishiki
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Yamane
mesh_terms: D000790:Angiocardiography / Q000662:veterinary; D000818:Animals; D001024:Aortic Valve Stenosis / Q000601:surgery / Q000662:veterinary*; D001705:Bioprosthesis / Q000662:veterinary*; D001794:Blood Pressure; D001807:Blood Vessel Prosthesis / Q000662:veterinary*; D006328:Cardiac Catheterization / Q000662:veterinary; D004283:Dog Diseases / Q000601:surgery*; D004285:Dogs; D004452:Echocardiography / Q000662:veterinary; D004853:Epoxy Resins; D005976:Glutaral; D011091:Polyesters; D011126:Polypropylenes; D011479:Protamines
chemical_list: D004853:Epoxy Resins; D011091:Polyesters; D011126:Polypropylenes; D011479:Protamines; C050906:polyglycerol polyglycidyl ether; C035364:Quetol 651; D005976:Glutaral