title: Cognitive effects of allergic rhinitis and its treatment.
abstract: Allergic rhinitis (AR) can, by itself, introduce significant sedation and impairment of cognition and performance. AR can also impede restorative sleep, resulting in increased fatigue and decreased daytime performance. It is not clear whether improved alertness resulting from blocking histamine production offsets the sedating effects of antihistamines or whether the effects of disease and treatment combine to create even greater sedation. This article reviews and integrates this literature, offers conclusions based on the collective evidence, and suggests guidelines for future research.
authors.affiliation: Division of Pediatric Behavioral Health, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA. benderb@njc.org
authors.forename: Bruce G
authors.initials: BG
authors.lastname: Bender
mesh_terms: D003072:Cognition Disorders / Q000209:etiology*; D006634:Histamine H1 Antagonists / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D006255:Rhinitis, Allergic, Seasonal / Q000150:complications* / Q000188:drug therapy / Q000628:therapy*; D012893:Sleep Wake Disorders / Q000209:etiology
chemical_list: D006634:Histamine H1 Antagonists