title: MSight: an image analysis software for liquid chromatography-mass spectrometry.
abstract: Images obtained from high-throughput mass spectrometry (MS) contain information that remains hidden when looking at a single spectrum at a time. Image processing of liquid chromatography-MS datasets can be extremely useful for quality control, experimental monitoring and knowledge extraction. The importance of imaging in differential analysis of proteomic experiments has already been established through two-dimensional gels and can now be foreseen with MS images. We present MSight, a new software designed to construct and manipulate MS images, as well as to facilitate their analysis and comparison.
authors.affiliation: Proteome Informatics Group, Swiss Institute of Bioinformatics, Geneva, Switzerland. patricia.palagi@isb-sib.ch
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Palagi
authors.forename: Daniel
authors.initials: D
authors.lastname: Walther
authors.forename: Manfredo
authors.initials: M
authors.lastname: Quadroni
authors.forename: Sébastien
authors.initials: S
authors.lastname: Catherinet
authors.forename: Jennifer
authors.initials: J
authors.lastname: Burgess
authors.forename: Catherine G
authors.initials: CG
authors.lastname: Zimmermann-Ivol
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Sanchez
authors.forename: Pierre-Alain
authors.initials: PA
authors.lastname: Binz
authors.forename: Denis F
authors.initials: DF
authors.lastname: Hochstrasser
authors.forename: Ron D
authors.initials: RD
authors.lastname: Appel
mesh_terms: D002853:Chromatography, Liquid; D015180:Electrophoresis, Gel, Two-Dimensional; D007091:Image Processing, Computer-Assisted; D010455:Peptides / Q000032:analysis; D020543:Proteome / Q000032:analysis; D012984:Software; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D010455:Peptides; D020543:Proteome