Myostatin, a negative regulator of muscle mass: implications for muscle degenerative diseases.
Myostatin is a secreted protein that negatively regulates skeletal muscle mass determining both muscle fiber number and size. The myostatin pathway is conserved and regulates muscle mass in a number of animal species ranging from fish to humans. Inhibition of myostatin using a variety of therapeutic approaches can increase muscle mass in a number of animal models of human disease, including muscular dystrophy.
Tobin
James F
JF
Department of Cardiovascular and Metabolic Diseases, Wyeth Research, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, USA. jtobin@wyeth.com
Celeste
Anthony J
AJ
D000818:Animals; D006801:Humans; D009135:Muscular Diseases / Q000503:physiopathology / Q000628:therapy*; D055435:Myostatin; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000009:adverse effects / Q000037:antagonists & inhibitors* / Q000502:physiology
C525911:MSTN protein, human; D055435:Myostatin; D016212:Transforming Growth Factor beta