Elevated 12- and 20-hydroxyeicosatetraenoic acid in urine of patients with prostatic diseases.
The role of eicosanoids (metabolites of arachidonic acid) in prostate diseases is receiving increased attention. We investigated the relationship between the concentrations of urinary free acids of 12- and 20-hydroxyeicosatetraenoic acids (12- and 20-HETE) and the benign prostatic hypertrophy (BPH) and prostate cancer (Pca). Urinary concentrations of 12-HETE and 20-HETE of BPH and Pca patients were significantly higher than normal subjects. After removal of the prostate gland, the urinary concentrations of these eicosanoids decreased to concentrations similar to the normal subjects. These results suggest that urinary free acids of 12-HETE and 20-HETE indicate an abnormality of the prostate gland.
Nithipatikom
Kasem
K
Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. kasemn@mcw.edu
Isbell
Marilyn A
MA
See
William A
WA
Campbell
William B
WB
D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid / Q000652:urine*; D000328:Adult; D000368:Aged; D002853:Chromatography, Liquid; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000652:urine*; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000378:metabolism; D011470:Prostatic Hyperplasia / Q000652:urine*; D011471:Prostatic Neoplasms / Q000652:urine*; D021241:Spectrometry, Mass, Electrospray Ionization
D006893:Hydroxyeicosatetraenoic Acids; D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; C055987:20-hydroxy-5,8,11,14-eicosatetraenoic acid