Cardioprotection with adenosine: 'a riddle wrapped in a mystery'.
Review of the published literature on adenosine and cardioprotection could lead one to paraphrase the famous words of Sir Winston Churchill (Radio broadcast, 1 October 1939 (in reference to Russia)) and conclude: 'I cannot forecast to you the action of adenosine. It is a riddle wrapped in a mystery inside an enigma'. That is, although it is well-established that adenosine can render cardiomyocytes resistant to lethal ischemia/reperfusion-induced injury, new and intriguing insights continue to emerge as to the mechanisms by which adenosine might limit myocardial infarct size.
Przyklenk
Karin
K
Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA. Karin.Przyklenk@umassmed.edu
Whittaker
Peter
P
D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology*; D009203:Myocardial Infarction / Q000517:prevention & control*; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D051381:Rats
D002316:Cardiotonic Agents; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D000241:Adenosine