Trypanosoma cruzi: effects of repetitive stress during the development of experimental infection.
Activation of the hypothalamus-pituitary-adrenal axis plays a major role in the suppression of the immune system. We have investigated the effects of repetitive stress on Wistar rats infected with the Y strain of Trypanosoma cruzi and a control group that underwent stressor stimuli by exposure to ether vapor for one minute twice a day. Repetitive stress resulted in an elevated number of circulating parasites accompanies by deep tissue disorganization, and cardiac histopathological alterations. The infected and stressed group displayed a decrease in body weight, and an increased parasite burden in heart tissue, and adrenal glands. Histological analysis of the heart also showed a moderate to severe diffused mononuclear inflammatory process. These results suggest that repetitive stress could be considered an important factor during development of experimental Chagas' disease, enhancing pathogenesis through disturbance of the host's immune system.
Santos
Carla D
CD
Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto FCFRP-USP, Universidade de São Paulo, Ribeirão Preto, SP, Brazil. carladom@fcfrp.usp.br
Caldeira
Jerri C
JC
Toldo
Míriam P A
MP
Prado
José C
JC
D000311:Adrenal Glands / Q000473:pathology; D000818:Animals; D001835:Body Weight / Q000276:immunology / Q000502:physiology; D014355:Chagas Disease / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D008297:Male; D009206:Myocardium / Q000473:pathology; D018512:Parasitemia / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012008:Recurrence; D013312:Stress, Physiological / Q000150:complications* / Q000276:immunology