title: Serial MR imaging and 1H-MR spectroscopy of unidentified bright objects in a case of neurofibromatosis type 1.
abstract: Serial study using MR imaging and 1H-MR spectroscopy (1H-MRS) of unidentified bright objects (UBO) in a 9-year-old boy with neurofibromatosis type 1 (NF1) is described. UBO was indicated in the left globus pallidum at 3 years old, then appeared in the right globus pallidum at 5 years old along with left hemiconvulsion. These UBO gradually disappeared over several years. On 1H-MRS, the ratios of N-acetylaspartate (NAA)/creatine and that of choline/creatine were each mildly reduced in the UBO. These ratios improved in parallel with disappearance of the UBO. In addition, elevation of the lactate/lipid peak was shown in UBO during the early stage, however, it disappeared in the latter. The longitudinal follow-up using MR image and 1H-MRS was useful for metabolic evaluation of UBO in patients with NF1.
authors.affiliation: Department of Pediatrics, Gifu Prefectural Gifu Hospital, 4-6-1 Noishiki, Gifu 500-8717, Japan. aimamura30@hotmail.com
authors.forename: Atsushi
authors.initials: A
authors.lastname: Imamura
authors.forename: Naoki
authors.initials: N
authors.lastname: Matsuo
authors.forename: Miho
authors.initials: M
authors.lastname: Okuda
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Morita
authors.forename: Masako
authors.initials: M
authors.lastname: Iwata
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: Yukitoshi
authors.initials: Y
authors.lastname: Takahashi
mesh_terms: D001921:Brain / Q000473:pathology; D002648:Child; D005917:Globus Pallidus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications / Q000473:pathology*; D012640:Seizures / Q000209:etiology