title: Solid-phase synthesis of oligonucleotides labeled with luminescent lanthanide(III) chelates.
abstract: The synthesis of phosphoramidite building blocks that allow introduction of luminescent europium(III), terbium(III), dysprosium(III), and samarium(III) chelates to oligonucleotides on the solid phase is described. Several labeled oligonucleotides using these building blocks were prepared, and the photophysical properties of these bioconjugates were investigated.
authors.affiliation: PerkinElmer Life and Analytical Sciences, Wallac Oy, P.O. Box 10, FIN-20101 Turku, Finland.
authors.forename: Lassi
authors.initials: L
authors.lastname: Jaakkola
authors.forename: Jari
authors.initials: J
authors.lastname: Peuralahti
authors.forename: Harri
authors.initials: H
authors.lastname: Hakala
authors.forename: Jenni
authors.initials: J
authors.lastname: Kunttu
authors.forename: Pekka
authors.initials: P
authors.lastname: Tallqvist
authors.forename: Veli-Matti
authors.initials: VM
authors.lastname: Mukkala
authors.forename: Alice
authors.initials: A
authors.lastname: Ylikoski
authors.forename: Jari
authors.initials: J
authors.lastname: Hovinen
mesh_terms: D002614:Chelating Agents / Q000737:chemistry*; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D049408:Luminescent Agents / Q000737:chemistry*; D015394:Molecular Structure; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry
chemical_list: D002614:Chelating Agents; D028581:Lanthanoid Series Elements; D049408:Luminescent Agents; D009841:Oligonucleotides; D011725:Pyridines; C023666:pyridine