Growth hormone and the cardiovascular function.
In this review, the great importance of growth hormone (GH) for the maintenance of cardiac function in adult life is discussed. Physiological effects of GH are discussed as well as the cardiac dysfunction caused both by GH excess (acromegaly) and by GH deficiency in adult hypopituitary patients. In both acromegaly and adult GH deficiency, there is also increased cardiovascular morbidity and mortality. Finally, the effect of GH treatment in heart failure is discussed.
Svensson
J
J
Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Sahlgrenska Academy, University of Göteborg, Göteborg, Sweden. Johan.Svensson@medic.gu.se
Tivesten
A
A
Isgaard
J
J
D000172:Acromegaly / Q000503:physiopathology; D000818:Animals; D002302:Cardiac Output / Q000502:physiology; D013006:Growth Hormone / Q000096:biosynthesis / Q000172:deficiency / Q000502:physiology* / Q000627:therapeutic use; D006321:Heart / Q000502:physiology* / Q000503:physiopathology; D006331:Heart Diseases / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007018:Hypopituitarism / Q000503:physiopathology; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D009206:Myocardium / Q000378:metabolism*; D016896:Treatment Outcome
D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone