Lignans from Schisandra hernyi with DNA cleaving activity and cytotoxic effect on leukemia and Hela cells in vitro.
The lignans, gomisin G (1), schisantherin A (2), benzoylgomisin Q (3) and isoanwulignan (4) were isolated from the stems of Schisandra henryi. Compound 1 showed moderate DNA strand scission activity and significant cytotoxic effect on leukemia and Hela cells in vitro. Compound 1 represents a new type of DNA strand scission agent.
Chen
Ye-Gao
YG
Department of Chemistry, Yunnan Normal University, Kunming, Yunnan 650092, China. ygchen48@hotmail.com
Wu
Zheng-Cai
ZC
Gui
Shi-Hong
SH
Lv
Yu-Ping
YP
Liao
Xin-Rong
XR
Halaweish
Fathi
F
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004247:DNA / Q000737:chemistry*; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D032141:Schisandra / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; D004247:DNA