title: [Pharmacotherapy in schizophrenia--comparison of second generation antipsychotic agents].
abstract: Schizophrenia is a severely limiting chronic illness. The disease is characterized by periods of psychoses, remission, and sometimes even recovery. Effective pharmacotherapy for schizophrenia began with the development of antipsychotic neuroleptics in the 1950's, followed by the second generation of antipsychotic agents developed in the 1990's. Across time, treatment with some of these preparations revealed extrapyramidal and other side effects, including metabolic phenomenon, such as: an increase in the incidence of diabetes, and weight gain. When choosing the appropriate medication from among the second generation of antipsychotic agents, the following aspects should be considered; cost, efficacy, unique advantages, employment rehabilitation, relapse and metabolic side effects. Therapeutic algorithms and recommended guidelines are helpful when planning treatment strategies. Information regarding prior beneficial treatments, cost, and the patient's quality of life should be considered. Today, when patients' rights, economic and legal aspects are emphasized, the physician must take into account multiple factors when choosing the most appropriate treatment for the patient.
authors.affiliation: Lev Hasharon Mental Health Center, Beilinson Hospital affiliated to the Sackler Faculty of Medicine, Tel Aviv University. ymelamed@lev-hasharon.co.il
authors.forename: Yuval
authors.initials: Y
authors.lastname: Melamed
authors.forename: Boris
authors.initials: B
authors.lastname: Finkel
authors.forename: Yoram
authors.initials: Y
authors.lastname: Barak
authors.forename: Patricia
authors.initials: P
authors.lastname: Zipris
authors.forename: Igor
authors.initials: I
authors.lastname: Oyffe
authors.forename: Abraham
authors.initials: A
authors.lastname: Weizman
authors.forename: Avi
authors.initials: A
authors.lastname: Bleich
mesh_terms: D000465:Algorithms; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D017408:Guidelines as Topic; D006801:Humans; D012559:Schizophrenia / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents