[The expression of PTEN and PKB in salivary adenoid cystic carcinoma and its clinical significance].
OBJECTIVE
To investigate the expression of PTEN and PKB in salivary adenoid cystic carcinoma (SACC) and its clinical significance.


METHODS
The expression of PTEN and PKB in 63 cases SACC were evaluated by SP immunohistochemistry. SPSS 11.5 software was used for chi-square test.


RESULTS
In 38 cases, both non-cancer tissue near by cancer and cancer tissue, 21 (55.26%) cases cancer tissue PTEN expression positive were found, 32 (84.21%) cases the non-cancer tissue near by cancer PTEN expression positive were found. There was significant difference in cancer tissue and non-cancer tissue near by cancer (P<0.05). 31 (81.58%) cases cancer tissue PKB expression positive were found, 20 (52.63%) cases the non-cancer tissue near by cancer PKB expression positive were found. There was significant difference in cancer tissue and non-cancer tissue near by cancer (P<0.01). In 25 cases with metastasis, 9 (36%) cases PTEN expression positive were found; in 38 cases with non-metastasis, 26 (68.42%) cases PTEN expression positive were found; there was significant difference in cases of metastasis and non-metastasis (P<0.05). In 25 cases with metastasis, 24 (96%) cases PKB expression positive were found; in 38 cases with non-metastasis, 27 (71.05%) cases PKB expression positive were found; There was significant difference in cases of metastasis and non-metastasis (P<0.05). PTEN expression and PKB expression were no significant difference between the different sex, age and sorts of pathology. PTEN and PKB were negatively correlated (P<0.01).


CONCLUSIONS
The expression of PTEN and PKB may be related to the occurrence and progress of salivary adenoid cystic carcinoma,PTEN and PKB may have effect on metastasis.
Shen
Lei
L
Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang 110002, Liaoning Province, China.
Sun
Chang-fu
CF
D003528:Carcinoma, Adenoid Cystic / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D051059:PTEN Phosphohydrolase / Q000235:genetics* / Q000378:metabolism; D012468:Salivary Gland Neoplasms / Q000378:metabolism*
D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human