title: Suggestive evidence for association of D2S2188 marker (2q31.1) with autism in 143 Sicilian (Italian) TRIO families.
abstract: We have screened 143 Sicilian (Italian) families with one autistic child to verify, by a linkage disequilibrium approach, the involvement of the 2q31.1 region in the cause of the disease in these families. Our study design includes the use of intrafamilial association to prevent a population stratification bias and ethnic homogeneity of the sample. The results of our analysis provided suggestive evidence of the occurrence of transmission disequilibrium between autism and the D2S2188 polymorphism in Sicilian TRIO families, a finding which provides further and independent support to the hypothesis of the existence of a susceptibility gene (or genes) for autism on chromosome 2q.
authors.affiliation: Dipartimento di Biopatologia e Metodologie Biomediche, Università degli Studi di Palermo, Palermo eIRCCS Oasi Maria SS, Troina (EN), Italy. vromano@unipa.it
authors.forename: Valentino
authors.initials: V
authors.lastname: Romano
authors.forename: Francesco
authors.initials: F
authors.lastname: Calì
authors.forename: Gregorio
authors.initials: G
authors.lastname: Seidita
authors.forename: Mario
authors.initials: M
authors.lastname: Mirisola
authors.forename: Rosalba P
authors.initials: RP
authors.lastname: D'Anna
authors.forename: Giovanna
authors.initials: G
authors.lastname: Gambino
authors.forename: Pietro
authors.initials: P
authors.lastname: Schinocca
authors.forename: Salvatore
authors.initials: S
authors.lastname: Romano
authors.forename: Giovanni F
authors.initials: GF
authors.lastname: Ayala
authors.forename: Fabio
authors.initials: F
authors.lastname: Canziani
authors.forename: Giacomo
authors.initials: G
authors.lastname: De Leo
authors.forename: Maurizio
authors.initials: M
authors.lastname: Elia
mesh_terms: D001321:Autistic Disorder / Q000453:epidemiology / Q000235:genetics*; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D005190:Family; D005819:Genetic Markers; D006801:Humans; D011110:Polymorphism, Genetic; D012802:Sicily / Q000453:epidemiology
chemical_list: D005819:Genetic Markers