title: Benzimidazolyl quinolinyl mercaptotriazoles as potential antimicrobial and antiviral agents.
abstract: Condensation of ethylaceto acetate (EAA) with resorcinol in concentrated H2SO4 afforded 7-hydroxy-4-methyl coumarin (1), which on reaction with thiosemicarbazide in anhydrous pyridine yielded 7-hydroxy-4-methyl-quinolinyl [1,5-c]-mercaptotriazole (2). Reaction of 2 with formaldehyde solution and amino acid in ethanol yielded 7-hydroxy-4-methyl-8-(N-methyl-aminoacid)-quinolinyl [1,5-c]-2''-mercaptotriazole (3a-e). Interaction of 3 with o-phenylenediamine in pyridine yielded 7-hydroxy-4-methyl-8-(aminobenzimidazolyl)-quinolinyl [1,5-c]-2''-mercaptotriazole derivatives (4a-e). The latter compounds were evaluated for their antiviral and antimicrobial activities.
authors.affiliation: Department of Chemistry, University of Lucknow, Lucknow-226007 (U.P.), India. vinodkumarpandey@rediffmail.com
authors.forename: Vinod Kumar
authors.initials: VK
authors.lastname: Pandey
authors.forename: Mridula
authors.initials: M
authors.lastname: Upadhyay
authors.forename: Mrinalini
authors.initials: M
authors.lastname: Upadhyay
authors.forename: Vishnu Dev
authors.initials: VD
authors.lastname: Gupta
authors.forename: Meenal
authors.initials: M
authors.lastname: Tandon
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004664:Encephalitis Virus, Japanese / Q000187:drug effects; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D018259:Herpesvirus 1, Human / Q000187:drug effects; D007711:Klebsiella pneumoniae / Q000187:drug effects; D051379:Mice; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011804:Quinolines / Q000138:chemical synthesis / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D014230:Triazoles / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: C503860:7-hydroxy-4-methyl-8-(N-methyl-aminoacid)-quinolinyl (1,5-c)-2''-mercaptotriazole; D000890:Anti-Infective Agents; D011804:Quinolines; D014230:Triazoles