title: [A study of insertion/delation polymorphism of the angiotensin-converting enzyme gene in pilots].
abstract: In order to understand insertion/delation (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene in pilots,and to explore the relationship between ACE gene I/D polymorphism and the performance of the pilots, the polymerase chain reaction (PCR) was used to determine the genotypes for an I/D polymorphism in intron 16 of the ACE gene in 118 pilots and 96 healthy subjects as controls. The result showed that the I/D polymorphism in intron 16 of the ACE gene was categorized into three genotypes: two deletion alleles (genotype DD), heterozygous alleles (genotype ID), and two insertion alleles (genotype II). The genotype II and I allele frequency were significantly higher in pilots (44.07% and 0.65) than that in healthy subjects (31.25% and 0.52). It is suggested that I gene of ACE may play a role in performance of the pilots.
authors.affiliation: Department of Molecular Biology, General Hospital of Air Force, Beijing 100036, China. Caiqing@ht.rol.cn.net
authors.forename: Qing
authors.initials: Q
authors.lastname: Cai
authors.forename: Hong-jin
authors.initials: HJ
authors.lastname: Liu
authors.forename: Mei-cai
authors.initials: MC
authors.lastname: Jiang
authors.forename: Shu-qiang
authors.initials: SQ
authors.lastname: Jiang
authors.forename: Yin-jing
authors.initials: YJ
authors.lastname: Wang
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zhan
authors.forename: Jian-dong
authors.initials: JD
authors.lastname: Jiang