title: Histopathological findings of the no-reflow phenomenon following coronary intervention for acute coronary syndrome.
abstract: Although no-reflow phenomenon may occur in patients that experience reperfusion after ischemia, there have been no reports describing the postmortem findings in these patients. We describe the findings of an autopsy in a 56-year-old man who experienced acute coronary syndrome with no-reflow phenomenon after coronary intervention. Macroscopic study demonstrated myocardial infarction with diffuse hemorrhage, and microscopic analysis revealed vascular damage and microembolization in the no-reflow area. In conclusion, coronary microembolization and damage to the small coronary artery may contribute to the pathogenesis of no-reflow phenomenon following coronary intervention in humans.
authors.affiliation: Department of Cardiovascular Medicine, Course of Medical and Dental Science, Graduate School of Biomedical Science, Nagasaki University, Sakamoto, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kawano
authors.forename: Takahiro
authors.initials: T
authors.lastname: Hayashida
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohtani
authors.forename: Munetake
authors.initials: M
authors.lastname: Kanda
authors.forename: Yuji
authors.initials: Y
authors.lastname: Koide
authors.forename: Takeshi
authors.initials: T
authors.lastname: Baba
authors.forename: Genji
authors.initials: G
authors.lastname: Toda
authors.forename: Isao
authors.initials: I
authors.lastname: Shimokawa
authors.forename: Katsusuke
authors.initials: K
authors.lastname: Yano
authors.forename: Ryozo
authors.initials: R
authors.lastname: Okada
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D004562:Electrocardiography; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology* / Q000503:physiopathology; D015428:Myocardial Reperfusion Injury / Q000473:pathology*