Plasmodium falciparum: characterization of a late asexual stage golgi protein containing both ankyrin and DHHC domains.
Proteins containing the DHHC motif have been shown to function as palmitoyl transferases. The palmitoylation of proteins has been shown to play an important role in the trafficking of proteins to the proper subcellular location. Herein, we describe a protein containing both ankyrin domains and a DHHC domain that is present in the Golgi of late schizonts of P. falciparum. The timing of expression as well as the location of this protein suggests that it may play an important role in the sorting of proteins to the apical organelles during the development of the asexual stage of the parasite.
Seydel
Karl B
KB
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Gaur
Deepak
D
Aravind
L
L
Subramanian
G
G
Miller
Louis H
LH
D000595:Amino Acid Sequence; D000818:Animals; D017487:Ankyrins / Q000737:chemistry* / Q000235:genetics; D015153:Blotting, Western; D002334:Carnitine O-Palmitoyltransferase / Q000737:chemistry / Q000378:metabolism; D017124:Conserved Sequence; D005455:Fluorescent Antibody Technique; D006056:Golgi Apparatus / Q000737:chemistry* / Q000201:enzymology; D007106:Immune Sera / Q000096:biosynthesis / Q000276:immunology; D018613:Microscopy, Confocal; D008969:Molecular Sequence Data; D010963:Plasmodium falciparum / Q000737:chemistry* / Q000201:enzymology / Q000648:ultrastructure; D015800:Protozoan Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D017487:Ankyrins; D007106:Immune Sera; D015800:Protozoan Proteins; D002334:Carnitine O-Palmitoyltransferase