title: Anti-ulcer and anti-oxidant activity of pepticare, a herbomineral formulation.
abstract: Pepticare, a herbomineral formulation of the Ayurveda medicine consisting of the herbal drugs: Glycyrrhiza glabra, Emblica officinalis and Tinospora cordifolia, was tested for its anti-ulcer and anti-oxidant activity in rats. Effects of various doses (125, 250, 500 and 1000mg/kg, p.o.) of Pepticare were studied on gastric secretion and gastric ulcers in pylorus-ligation and on ethanol-induced gastric mucosal injury in rats. The reduction in ulcer index in both the models along with the reduction in volume and total acidity, and an increase in the pH of gastric fluid in pylorus-ligated rats proved the anti-ulcer activity of Pepticare. It was also found that Pepticare was more potent than G. glabra alone in protecting against pylorus-ligation and ethanol-induced ulcers. The increase in the levels of superoxide dismutase, catalase, reduced glutathione and membrane bound enzymes like Ca2+ ATPase, Mg2+ ATPase and Na+ K+ ATPase and decrease in lipid peroxidation in both the models proved the anti-oxidant activity of the formulation. Thus it can be concluded that Pepticare possesses anti-ulcer activity, which can be attributed to its anti-oxidant mechanism of action.
authors.affiliation: Department of Pharmacy, Faculty of Technology and Engineering, M.S. University of Baroda, Kalabhavan, Baroda 390 001, Gujarat, India.
authors.forename: P A
authors.initials: PA
authors.lastname: Bafna
authors.forename: R
authors.initials: R
authors.lastname: Balaraman
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000431:Ethanol; D019665:Euphorbiaceae; D005260:Female; D005638:Fruit; D005744:Gastric Acid / Q000378:metabolism; D006035:Glycyrrhiza; D006863:Hydrogen-Ion Concentration; D008026:Ligation; D015227:Lipid Peroxidation / Q000187:drug effects; D029583:Menispermaceae; D008517:Phytotherapy; D018517:Plant Roots; D018514:Plant Structures; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D000897:Anti-Ulcer Agents; D000975:Antioxidants; D000431:Ethanol