Choroidal vasculature in diabetic rats.
This study aims to evaluate the diabetic influence on the choroidal vessels morphology. Twenty Wistar rats were divided into a control (CG) and a diabetic group (DG). The animals had the diabetes induced by an intra-venous injection of Alloxan (42 mg/kg). Transmission electron microscopy analysis focusing the choroidal vessels was done one (T2) and twelve (T3) months after the diabetes induction. The CG rats in T3 showed vesicles and dense bodies in the endothelial and pericytic cells; the same structures were observed in the DG at T2. The DG rats in T3 had even more and intense changes than the T2DG rats. The morphological evaluation indicates that the choroidal vessels are affected in diabetes and the disease accelerates degenerative processes in the rat choroidal vasculature.
Rodrigues
A C L
AC
Department of Ophthalmology, School of Medicine of Botucatu, State University, São Paulo State, Brazil. eye_acr@fmb.unesp.br
Schellini
S A
SA
Gregório
E A
EA
Spadella
C T
CT
Padovani
C R
CR
D000496:Alloxan; D000818:Animals; D001485:Basement Membrane / Q000648:ultrastructure; D002196:Capillaries / Q000648:ultrastructure; D002829:Choroid / Q000098:blood supply / Q000648:ultrastructure*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000473:pathology*; D042783:Endothelial Cells / Q000648:ultrastructure; D005260:Female; D008297:Male; D046529:Microscopy, Electron, Transmission; D051381:Rats; D017208:Rats, Wistar; D017154:Stromal Cells / Q000648:ultrastructure
D000496:Alloxan