[Cushing's syndrome and adrenal adenoma. Two surprising associations].
BACKGROUND
Cushing's syndrome has a very low incidence (1-10 cases/million/year), and familial cases are even more rare. We report on two situations involving different causes of Cushing's syndrome.


METHODS
In the first case, we describe the case of a patient with an adrenal adenoma 20 years before the occurrence of Cushing's disease related to the pineal gland. In the second case, two members of the same family were diagnosed almost simultaneously with adrenal cortical adenoma (mother) and Cushing's disease (daughter).


CONCLUSIONS
These cases lead us to consider the known causes of familial Cushing's syndrome, which were not found here.
Ouzounian
S
S
Service des maladies endocriniennes et métaboliques, Hôpital Cochin, Paris.
Tissier
F
F
Gouya
H
H
Kujas
M
M
Louvel
A
A
Legmann
P
P
Bertagna
X
X
D000236:Adenoma / Q000150:complications*; D000310:Adrenal Gland Neoplasms / Q000150:complications*; D000328:Adult; D003480:Cushing Syndrome / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D013997:Time Factors