title: An A/G polymorphism of core 2 branching enzyme gene is associated with prostate cancer.
abstract: The expression of core 2 beta1,6-N-acetylglucosaminyltransferase-1 (C2GnT) is associated with development and progression of malignancy. Sequence analysis showed that the codon 152 of C2GnT has a polymorphism having GTT encoding valine or ATT encoding isoleucine. By examining the polymorphism in prostate cancer and benign prostatic hyperplasia patients, we found that the C2GnT G allele was more frequently observed in the prostate cancer group (p=0.015) than the control group. Men with the GG genotype had a 3.60-fold increased risk of prostate cancer, and men with the AG genotype had a 1.58-fold increased risk of prostate cancer compared with those with the AA genotype. The G allele was found to have a gene dosage effect for prostate cancer risk. No such risk was associated for benign prostatic hyperplasia. These results demonstrate that C2GnT A/G polymorphism is associated with the susceptibility to prostate cancer in a Japanese population.
authors.affiliation: Department of Urology, Akita University School of Medicine, Akita, Japan.
authors.forename: Lizhong
authors.initials: L
authors.lastname: Wang
authors.forename: Junya
authors.initials: J
authors.lastname: Mitoma
authors.forename: Norihiko
authors.initials: N
authors.lastname: Tsuchiya
authors.forename: Shintaro
authors.initials: S
authors.lastname: Narita
authors.forename: Yohei
authors.initials: Y
authors.lastname: Horikawa
authors.forename: Tomonori
authors.initials: T
authors.lastname: Habuchi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Imai
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Ishimura
authors.forename: Chikara
authors.initials: C
authors.lastname: Ohyama
authors.forename: Minoru
authors.initials: M
authors.lastname: Fukuda
mesh_terms: D015061:1,4-alpha-Glucan Branching Enzyme / Q000235:genetics*; D000368:Aged; D001483:Base Sequence; D016022:Case-Control Studies; D017931:DNA Primers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000201:enzymology*
chemical_list: D017931:DNA Primers; D015061:1,4-alpha-Glucan Branching Enzyme