title: Methylenetetrahydrofolate reductase C677T polymorphism and Factor V Leiden variant in Mexican women with preeclampsia/eclampsia.
abstract: The etiology of preeclampsia is still a matter of controversy. An association between hyperhomocysteinemia and preeclamptic patients has been described. A common missense mutation in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with increased plasma homocysteine concentrations. In addition, the polymorphism of gene encoding for Factor V Leiden G1691A is associated with a prothrombotic state in heterozygous subjects. Both mutations in these thrombophilic proteins appear to have different prevalence in the general population and in patients with preeclampsia/eclampsia (PE/E). We studied single nucleotide polymorphisms for MTHFR C677T and coagulation Factor V Leiden in 33 Mexican patients with PE/E as a genetic risk factor for these diseases, comparing with a normotensive pregnant control group. The genotype and allele frequencies of MTHFR C677T and Factor V Leiden mutations between Mexican women with PE/E and healthy controls were not different. We conclude that these polymorphisms do not contribute in the etiology of PE/E as it has been reported in other populations.
authors.affiliation: Divisiones de Genética y Medicina Molecular del Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Sierra Mojada 800, Col. Independencia, CMNO, CP 44330, Guadalajara, Jal. Mexico. ingriddavalos@hotmail.com
authors.forename: I P
authors.initials: IP
authors.lastname: Dávalos
authors.forename: M C
authors.initials: MC
authors.lastname: Moran
authors.forename: E
authors.initials: E
authors.lastname: Martínez-Abundis
authors.forename: M
authors.initials: M
authors.lastname: González-Ortiz
authors.forename: S E
authors.initials: SE
authors.lastname: Flores-Martínez
authors.forename: V
authors.initials: V
authors.lastname: Machorro
authors.forename: L
authors.initials: L
authors.lastname: Sandoval
authors.forename: L E
authors.initials: LE
authors.lastname: Figuera
authors.forename: J P
authors.initials: JP
authors.lastname: Mena
authors.forename: J M
authors.initials: JM
authors.lastname: Oliva
authors.forename: J A
authors.initials: JA
authors.lastname: Tlacuilo-Parra
authors.forename: J
authors.initials: J
authors.lastname: Sánchez-Corona
authors.forename: M
authors.initials: M
authors.lastname: Salazar-Páramo
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008800:Mexico; D017720:Molecular Epidemiology; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000209:etiology / Q000235:genetics*; D011247:Pregnancy; D015995:Prevalence
chemical_list: C095381:factor V Leiden; D005165:Factor V; D042965:Methylenetetrahydrofolate Reductase (NADPH2)