title: The impact of argyrophilic grain disease on the development of dementia and its relationship to concurrent Alzheimer's disease-related pathology.
abstract: Argyrophilic grain disease (AGD) constitutes a neurodegenerative disorder that occurs in the brains of the elderly and affects 5% of all patients with dementia. Tau protein-containing lesions known as argyrophilic grains and located predominantly in limbic regions of the brain characterize this disease. Dementia is encountered in only a subset of cases that display the morphological pattern of AGD. The aim of this study is to determine the role of concurrent Alzheimer's disease (AD)-related pathology for the development of dementia in AGD patients. A total of 204 post-mortem brains from 30 demented and 49 nondemented AGD patients, 39 AD patients, and from 86 nondemented controls without AGD were staged for AD-related neurofibrillary tangles (NFTs) as well as amyloid beta-protein (Abeta) deposition. To identify differences in AD-related pathology between demented and nondemented AGD cases, and to differentiate the pattern of AD-related changes in demented and nondemented AGD cases from that seen in AD and nondemented controls, we statistically compared the stages of Abeta and NFT distribution among these groups. Using a logistic regression model, we showed that AGD has a significant effect on the development of dementia beyond that attributable to AD-related pathology (P < 0.005). Demented AGD cases showed lower stages of AD-related pathology than did pure AD cases but higher stages than nondemented AGD patients. AGD associated dementia was seen in the presence of NFT (Braak)-stages II-IV and Abeta-phases 2-3, whereas those stages were not associated with dementia in the absence of AGD. In conclusion, AGD is a clinically relevant neurodegenerative entity that significantly contributes to the development of dementia by lowering the threshold for cognitive deficits in the presence of moderate amounts of AD-related pathology.
authors.affiliation: Department of Neuropathology, University of Bonn Medical Center, D-53105 Bonn, Germany. Dietmar.Thal@uni-bonn.de
authors.forename: D R
authors.initials: DR
authors.lastname: Thal
authors.forename: C
authors.initials: C
authors.lastname: Schultz
authors.forename: G
authors.initials: G
authors.lastname: Botez
authors.forename: K
authors.initials: K
authors.lastname: Del Tredici
authors.forename: R E
authors.initials: RE
authors.lastname: Mrak
authors.forename: W S T
authors.initials: WS
authors.lastname: Griffin
authors.forename: O D
authors.initials: OD
authors.lastname: Wiestler
authors.forename: H
authors.initials: H
authors.lastname: Braak
authors.forename: E
authors.initials: E
authors.lastname: Ghebremedhin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000150:complications* / Q000473:pathology; D016874:Neurofibrillary Tangles / Q000473:pathology
chemical_list: D016229:Amyloid beta-Peptides