title: Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection.
abstract: Chronic granulomatous disease (CGD) is characterized by life-threatening bacterial and fungal infections. Treatment with posaconazole led to a complete response in 7 of 8 patients with CGD with invasive mold infections (7 proven cases and 1 possible case) after failure or intolerance of treatment with standard antifungal agents. In this preliminary study, salvage treatment with posaconazole was safe and effective.
authors.affiliation: Department of Medicine, Division of Infectious Diseases, Roswell Park Cancer Institute, Buffalo, NY, USA.
authors.forename: Brahm H
authors.initials: BH
authors.lastname: Segal
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Barnhart
authors.forename: Victoria L
authors.initials: VL
authors.lastname: Anderson
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Walsh
authors.forename: Harry L
authors.initials: HL
authors.lastname: Malech
authors.forename: Steven M
authors.initials: SM
authors.lastname: Holland
mesh_terms: D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D002648:Child; D005260:Female; D005658:Fungi / Q000302:isolation & purification* / Q000472:pathogenicity; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000150:complications* / Q000188:drug therapy* / Q000235:genetics / Q000382:microbiology; D008297:Male; D016879:Salvage Therapy; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole