title: The design and implementation of the immune epitope database and analysis resource.
abstract: Epitopes are defined as parts of antigens interacting with receptors of the immune system. Knowledge about their intrinsic structure and how they affect the immune response is required to continue development of techniques that detect, monitor, and fight diseases. Their scientific importance is reflected in the vast amount of epitope-related information gathered, ranging from interactions between epitopes and major histocompatibility complex molecules determined by X-ray crystallography to clinical studies analyzing correlates of protection for epitope based vaccines. Our goal is to provide a central resource capable of capturing this information, allowing users to access and connect realms of knowledge that are currently separated and difficult to access. Here, we portray a new initiative, "The Immune Epitope Database and Analysis Resource." We describe how we plan to capture, structure, and store this information, what query interfaces we will make available to the public, and what additional predictive and analytical tools we will provide.
authors.affiliation: La Jolla Institute of Allergy and Immunology, 3030 Bunker Hill Street, Suite 326, San Diego, CA 92109, USA.
authors.forename: Bjoern
authors.initials: B
authors.lastname: Peters
authors.forename: John
authors.initials: J
authors.lastname: Sidney
authors.forename: Phil
authors.initials: P
authors.lastname: Bourne
authors.forename: Huynh-Hoa
authors.initials: HH
authors.lastname: Bui
authors.forename: Soeren
authors.initials: S
authors.lastname: Buus
authors.forename: Grace
authors.initials: G
authors.lastname: Doh
authors.forename: Ward
authors.initials: W
authors.lastname: Fleri
authors.forename: Mitch
authors.initials: M
authors.lastname: Kronenberg
authors.forename: Ralph
authors.initials: R
authors.lastname: Kubo
authors.forename: Ole
authors.initials: O
authors.lastname: Lund
authors.forename: David
authors.initials: D
authors.lastname: Nemazee
authors.forename: Julia V
authors.initials: JV
authors.lastname: Ponomarenko
authors.forename: Muthu
authors.initials: M
authors.lastname: Sathiamurthy
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Schoenberger
authors.forename: Scott
authors.initials: S
authors.lastname: Stewart
authors.forename: Pamela
authors.initials: P
authors.lastname: Surko
authors.forename: Scott
authors.initials: S
authors.lastname: Way
authors.forename: Steve
authors.initials: S
authors.lastname: Wilson
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sette
mesh_terms: D000818:Animals; D016208:Databases, Factual; D000939:Epitopes; D006801:Humans; D016056:Immunodominant Epitopes; D020407:Internet; D017434:Protein Structure, Tertiary
chemical_list: D000939:Epitopes; D016056:Immunodominant Epitopes