Effect of nifedipine on C-reactive protein levels in the coronary sinus and on coronary blood flow in response to acetylcholine in patients with stable angina pectoris having percutaneous coronary intervention.
The effects of nifedipine on inflammation and endothelial function in the coronary circulation were studied in patients who had angina pectoris (n = 17). Long-term treatment with nifedipine (nifedipine CR, 20 mg/day for 4 months) decreased levels of C-reactive protein in the coronary sinus (from 0.35 +/- 0.09 mg/dl to 0.07 +/- 0.01 mg/dl, mean +/- SEM, p <0.05) and enhanced acetylcholine-induced increases in coronary blood flow. Thus, nifedipine is effective in decreasing inflammation and incresing endothelial function in the coronary circulation.
Takase
Hiroyuki
H
Department of Internal Medicine, Enshu General Hospital, Hamamatsu.
Toriyama
Takayuki
T
Sugiyama
Masaya
M
Nakazawa
Ai
A
Hayashi
Kunihiko
K
Goto
Takatoshi
T
Sugiura
Tomonori
T
Ikeda
Koshiro
K
Sato
Koichi
K
Ueda
Ryuzo
R
Dohi
Yasuaki
Y
D000109:Acetylcholine / Q000494:pharmacology; D000368:Aged; D000787:Angina Pectoris / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000201:enzymology / Q000473:pathology; D015906:Angioplasty, Balloon, Coronary; D001783:Blood Flow Velocity; D002097:C-Reactive Protein / Q000378:metabolism*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D003326:Coronary Circulation / Q000187:drug effects; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome; D014463:Ultrasonography; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*
D014665:Vasodilator Agents; D002097:C-Reactive Protein; D009543:Nifedipine; D000109:Acetylcholine