Binding antibody to neutralizing epitope gp41 in HIV-1 subtype CRF 01_AE infection related to stage of disease.
The responsiveness of gp41 antibody against epitope ELDKWA in HIV-1 infected subjects is of importance in neutralizing viral infectivity and for being related to disease progression. In this study, antibody titers to this neutralizing epitope from HIV-1 infected subjects at asymptomatic and AIDS stages in Thailand were investigated by peptide ELISA. The results showed that the frequency of antibody production against this neutralizing epitope was low (15-35%). Moreover, antibody titers to this epitope in sera from AIDS patients were significantly lower than those in sera from asymptomatic subjects which were collected in the same year (p=0.001). Comparison between the past (1992-1994) and present (2002) sera from asymptomatic infected individuals revealed that the earlier panel contained lower antibody titers than the later panel did (p = 0.05). In addition, random sera for HIV-1 infected subjects who were infected by diverse genetic subtypes, (A through G) including CRF 01_AE, had low titers of antibody to this region as well. It is assumed that antibody production to this epitope is low and related to the stage of HIV-1 infection.
Srisurapanon
Surangrat
S
Department of Pathology, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand.
Louisirirotchanakul
Suda
S
Sumransurp
Kwonchit
K
Ratanasrithong
Monthaswad
M
Chuenchitra
Thippawan
T
Jintakatkorn
Siriporn
S
Wasi
Chantapong
C
D000595:Amino Acid Sequence; D018450:Disease Progression; D018604:Epitope Mapping; D018984:Epitopes, T-Lymphocyte; D015483:HIV Antibodies / Q000097:blood / Q000276:immunology*; D015488:HIV Antigens; D015700:HIV Envelope Protein gp41 / Q000276:immunology*; D006679:HIV Seropositivity; D015497:HIV-1 / Q000145:classification / Q000235:genetics / Q000276:immunology*; D006801:Humans; D016056:Immunodominant Epitopes; D008969:Molecular Sequence Data; D009500:Neutralization Tests
D018984:Epitopes, T-Lymphocyte; D015483:HIV Antibodies; D015488:HIV Antigens; D015700:HIV Envelope Protein gp41; D016056:Immunodominant Epitopes