Protective effect of astaxanthin on naproxen-induced gastric antral ulceration in rats.
Frequently used for humans as non-steroidal anti-inflammatory drug, naproxen has been known to induce ulcerative gastric lesion. The present study investigated the in vivo protective effect of astaxanthin isolated from Xanthophyllomyces dendrorhous against naproxen-induced gastric antral ulceration in rats. The oral administration of astaxanthin (1, 5, and 25 mg/kg of body weight) showed a significant protection against naproxen (80 mg/kg of body weight)-induced gastric antral ulcer and inhibited elevation of the lipid peroxide level in gastric mucosa. In addition, pretreatment of astaxanthin resulted in a significant increase in the activities of radical scavenging enzymes such as superoxide dismutase, catalase, and glutathione peroxidase. A histologic examination clearly proved that the acute gastric mucosal lesion induced by naproxen nearly disappeared after the pretreatment of astaxanthin. These results suggest that astaxanthin removes the lipid peroxides and free radicals induced by naproxen, and it may offer potential remedy of gastric ulceration.
Kim
Jeong-Hwan
JH
Department of Biotechnology, School of Life Sciences and Biotechnology, Korea University, Seoul 136-701, South Korea.
Kim
Young-Sik
YS
Song
Gwan-Gyu
GG
Park
Jong-Jae
JJ
Chang
Hyo-Ihl
HI
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005979:Glutathione Peroxidase / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009288:Naproxen / Q000008:administration & dosage / Q000633:toxicity; D011706:Pyloric Antrum / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000378:metabolism; D013997:Time Factors; D024341:Xanthophylls; D019207:beta Carotene / Q000031:analogs & derivatives* / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D024341:Xanthophylls; D019207:beta Carotene; D008315:Malondialdehyde; D009288:Naproxen; C005948:astaxanthine; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase