Histamine helps development of eczematous lesions in experimental contact dermatitis in mice.
Histamine is released from mast cells in the skin, causing urticaria and itching. However, little is known about the roles of histamine in development of eczematous lesions in contact dermatitis. Effects of histamine on development of eczematous lesions in contact dermatitis were assessed using histamine-deficient mice in which contact dermatitis was developed by repeated application of diphenylcyclopropenone. Development of eczematous lesions in contact dermatitis was suppressed in histamine-deficient mice compared to wild-type mice. H(1) agonist ((6-12-(4-imidazol)ethylamino)-N-(4-trifluoro- methylphenyl)hepatanecarboxamide) promoted development of eczematous lesions in histamine-deficient mice. H(1) receptor antagonist (loratadine) suppressed development of eczematous lesions in wild-type mice, whereas H(2) agonist (dimaprit) and receptor antagonist (cimetidine) were ineffective. These results suggest that histamine facilitates the development of eczematous lesions in a murine model of contact dermatitis via H(1) receptors.
Seike
Masahiro
M
Department of Dermatology, Kochi Medical School, Nankoku, Kochi 783-8505, Japan. seikema@kochi-ms.ac.jp
Takata
Tomoya
T
Ikeda
Mitsunori
M
Kodama
Hajime
H
Terui
Tadashi
T
Ohtsu
Hiroshi
H
D000818:Animals; D003877:Dermatitis, Contact / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control; D005260:Female; D006632:Histamine / Q000502:physiology*; D017442:Histamine Agonists / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006640:Histidine Decarboxylase / Q000235:genetics; D015850:Interleukin-6 / Q000096:biosynthesis; D016209:Interleukin-8 / Q000096:biosynthesis; D051379:Mice; D018345:Mice, Knockout; D043562:Receptors, G-Protein-Coupled / Q000502:physiology; D011968:Receptors, Histamine / Q000502:physiology; D000074040:Receptors, Histamine H4
D017442:Histamine Agonists; D006634:Histamine H1 Antagonists; C498829:Hrh4 protein, mouse; D015850:Interleukin-6; D016209:Interleukin-8; D043562:Receptors, G-Protein-Coupled; D011968:Receptors, Histamine; D000074040:Receptors, Histamine H4; D006632:Histamine; D006640:Histidine Decarboxylase