title: Microneurography of human median nerve.
abstract: OBJECTIVE
  To examine the possibility of performing high-resolution MRI (microneurography) on peripheral nerves.
  
  
  METHODS
  A specific radio frequency (RF) coil was developed to probe the human median nerve at a magnetic field strength of 9.4 T and tested on three excised samples by acquiring microneurograms.
  
  
  RESULTS
  The microneurograms revealed neuronal tissue constituents at subfascicular level. The contrast features on proton-density and T1- and T2-weighted images were described and compared. The microscopic water movement was quantified using diffusion weighting parallel and orthogonal to the neuronal fiber orientation. The characteristics of anisotropic diffusion in the median nerve were comparable to those reported from other biological tissues (white matter and kidney).
  
  
  CONCLUSIONS
  The results overall suggest that microneurography might provide new noninvasive insights into microscopic gross anatomy of the peripheral nerve, injury evaluation, and efficacy of repair, although the feasibility at current clinically relevant field strengths is yet to be determined.
authors.affiliation: Hoglund Brain Imaging Center, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA. mbilgen@kumc.edu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Bilgen
authors.forename: Archie
authors.initials: A
authors.lastname: Heddings
authors.forename: Baraa
authors.initials: B
authors.lastname: Al-Hafez
authors.forename: Wohaib
authors.initials: W
authors.lastname: Hasan
authors.forename: Terence
authors.initials: T
authors.lastname: McIff
authors.forename: Bruce
authors.initials: B
authors.lastname: Toby
authors.forename: Randolph
authors.initials: R
authors.lastname: Nudo
authors.forename: William M
authors.initials: WM
authors.lastname: Brooks
mesh_terms: D002102:Cadaver; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D008297:Male; D008475:Median Nerve / Q000033:anatomy & histology*