Four cases of simultaneous triple primary cancers of the hypopharynx, esophagus, and stomach.
OBJECTIVE
To study the efficacy of intensive chemotherapy for simultaneous triple primary cancers of the hypopharynx, esophagus, and stomach.


METHODS
Retrospective case study.


METHODS
From April 2000 to March 2002, we treated 4 patients who had simultaneous triple primary cancers, including hypopharyngeal, esophageal, and gastric carcinomas. These 4 patients were designated as the objects for analysis, and the treatment modality for simultaneous multiple primary cancer cases was examined.


RESULTS
In 3 of 4 patients, all 3 primary cancers could be controlled by intensive induction chemotherapy and concurrent chemoradiotherapy for hypopharyngeal cancer and by endoscopic mucosal resection or argon plasma coagulation for esophageal and gastric carcinomas.


CONCLUSIONS
In the treatment modality for simultaneous multiple primary cancers, including head and neck cancer, it is important to select intensive systemic chemotherapy and decide the order for treating each primary lesion in consideration of each patient's curability and prognosis.
Ikeda
Yoichi
Y
Department of Otolaryngology, Yokohama City University Medical Center, Fujisawa City Hospital, 2-6-1 Fujisawa, Fujisawa City, Kanagawa 251-8550, Japan. ikeda.y@jcom.home.ne.jp
Tsukuda
Mamoru
M
Ishitoya
Junichi
J
Arai
Yasuhiro
Y
Matsuda
Hideki
H
Katori
Hideaki
H
Taguchi
Takahide
T
Yoshida
Takafumi
T
Ono
Machiko
M
Sakuma
Yasunori
Y
Yagisawa
Mizuho
M
Saito
Norifumi
N
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy*; D005753:Gastric Mucosa; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D011379:Prognosis; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000601:surgery