title: Mitomycin C and epirubicin: functional bladder damage in rats after repeat intravesical instillations.
abstract: OBJECTIVE
  We studied functional damage in the bladder after intravesical administration of mitomycin C or epirubicin in rats.
  
  
  METHODS
  A total of 40 rats were divided into 4 groups. Rats in 3 groups received intravesical instillations of mitomycin C, epirubicin or saline. Rats in group 4 received no intravesical instillations and served as normal controls. The doses of drugs administered were based on those used for therapeutic purposes. Changes in vesical capacity and bladder wall compliance were determined. Compliance was defined as the change in vesical volume induced by a given change in pressure.
  
  
  RESULTS
  Weekly instillations of 1 mg/ml mitomycin C caused a statistically significant decrease in vesical volume and compliance, which persisted 3 weeks after the cessation of therapy. Epirubicin also induced changes in vesical volume and compliance but only that in bladder compliance achieved statistical significance. These changes were not seen in NaCl treated animals or in normal controls.
  
  
  CONCLUSIONS
  Repeat intravesical instillations of mitomycin C have a prolonged effect on bladder function that is not seen after saline solution or epirubicin instillation.
authors.affiliation: Department of Urology, University of Antwerp, Edegem, Belgium.
authors.forename: Dirk
authors.initials: D
authors.lastname: Michielsen
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Amy
authors.forename: Danny
authors.initials: D
authors.lastname: Coomans
authors.forename: Guy
authors.initials: G
authors.lastname: Storme
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Wyndaele
mesh_terms: D000283:Administration, Intravesical; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000633:toxicity*; D015251:Epirubicin / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D016685:Mitomycin / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D001743:Urinary Bladder / Q000187:drug effects* / Q000473:pathology; D014563:Urodynamics / Q000187:drug effects; D015430:Weight Gain / Q000187:drug effects
chemical_list: D000903:Antibiotics, Antineoplastic; D015251:Epirubicin; D016685:Mitomycin