Xanthones from Garcinia smeathmannii (Oliver) and their antimicrobial activity.
Two new xanthones, smeathxanthone A (1) (2-(3,7-dimethyl-2,6-octadienyl)-1,3,5,8-tetrahydroxyxanthone) and smeathxanthone B (2) (5,7,10-trihydroxy-2-methyl-2-(4-methylpent-3-enyl)[2H, 6H]pyrano[3,2-b]xanthen-6-one), have been isolated from the stem bark of Garcinia smeathmannii, and their structures elucidated on the basis of 1D and 2D NMR experiments. 1,3,5-Trihydroxyxanthone and 1,5-dihydroxyxanthone were also obtained. The compounds showed only modest activity against a range of bacteria and yeasts.
Komguem
Justin
J
Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
Meli
A L
AL
Manfouo
R N
RN
Lontsi
David
D
Ngounou
F N
FN
Kuete
V
V
Kamdem
Hippolyte W
HW
Tane
Pierre
P
Ngadjui
Bonaventure T
BT
Sondengam
Beiban L
BL
Connolly
Joseph D
JD
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D029760:Garcinia / Q000737:chemistry*; D015394:Molecular Structure; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
C505174:2-(3,7-dimethyl-2,6-octadienyl)-1,3,5,8-tetrahydroxyxanthone; C505173:5,7,10-trihydroxy-2-methyl-2-(4-methylpent-3-enyl)(2H,6H)pyrano(3,2-b)xanthen-6-one; D000890:Anti-Infective Agents; D044004:Xanthones