title: Antileishmanial and antifungal activities of xanthanolides isolated from Xanthium macrocarpum.
abstract: Seven xanthanolides, xanthinosin, xanthatin, 4-hydroxyxanthinosin, xanthinin, 4-epiisoxanthanol, 4-epixanthanol, 2-hydroxyxanthinosin and 4-oxobedfordia acid, were isolated from the fruits of Xanthium macrocarpum. A valuation of the antifungal activity of these xanthanolides against Candida albicans, Candida glabrata and Aspergillus fumigatus and of their antileishmanial activity against Leishmania infantum and Leishmania mexicana is presented.
authors.affiliation: SONAS UPRES-EA 921, UFR des Sciences Pharmaceutiques et Ingéniérie de la santé, 16 Bd Daviers, Angers, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Lavault
authors.forename: Anne
authors.initials: A
authors.lastname: Landreau
authors.forename: Gérald
authors.initials: G
authors.lastname: Larcher
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Bouchara
authors.forename: Fabrice
authors.initials: F
authors.lastname: Pagniez
authors.forename: Patrice
authors.initials: P
authors.lastname: Le Pape
authors.forename: Pascal
authors.initials: P
authors.lastname: Richomme
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D005658:Fungi / Q000187:drug effects; D007891:Leishmania / Q000187:drug effects*; D018515:Plant Leaves / Q000737:chemistry; D031210:Xanthium / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D000981:Antiprotozoal Agents