title: A functional polymorphism of the NFKB1 promoter is not associated with ulcerative colitis in a Spanish population.
abstract: BACKGROUND
  This study investigated the influence of the NFKB1-94ins/delATTG in the susceptibility/phenotype to ulcerative colitis.
  
  
  METHODS
  We analyzed the distribution of -94ins/delATTG NFKB1 in 258 patients and 264 healthy controls from southern Spain by a polymerase chain reaction-fluorescent method.
  
  
  RESULTS
  The genotype and allele frequencies of -94ins/delATTG did not significantly differ between patients and controls. In fact, the frequency of the -94delATTG allele was almost identical in both groups (34.8% and 35.4%, respectively), and the del/del genotype was underrepresented in UC patients (11.2% versus 14%). In addition, no association of this polymorphism was found with any of the clinical parameters analyzed.
  
  
  CONCLUSIONS
  These results suggest that the NFKB1 -94ins/delATTG gene variation, previously associated with UC susceptibility in North Americans, does not influence either susceptibility or phenotype of UC in the Spanish population.
authors.affiliation: Instituto de Parasitología y Biomedicina López Neyra, Granada, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Oliver
authors.forename: María
authors.initials: M
authors.lastname: Gómez-García
authors.forename: Laura
authors.initials: L
authors.lastname: Paco
authors.forename: Miguel A
authors.initials: MA
authors.lastname: López-Nevot
authors.forename: Alexis
authors.initials: A
authors.lastname: Piñero
authors.forename: Francisco
authors.initials: F
authors.lastname: Correro
authors.forename: Leopoldo
authors.initials: L
authors.lastname: Martín
authors.forename: José A
authors.initials: JA
authors.lastname: Brieva
authors.forename: Antonio
authors.initials: A
authors.lastname: Nieto
authors.forename: Javier
authors.initials: J
authors.lastname: Martín
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000208:ethnology / Q000209:etiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D052002:NF-kappa B p50 Subunit; D010641:Phenotype; D011110:Polymorphism, Genetic; D013030:Spain; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology*
chemical_list: D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human; D014157:Transcription Factors