title: Possibilities and limitations of fibrin glue usage in nephron-sparing surgery: experimental study.
abstract: BACKGROUND
  The possibilities and limitations of fibrin glue (FG) usage in nephron-sparing surgery were studied.
  
  
  METHODS
  A prospective experimental study was carried out in 50 pigs: 30 with polar resection, and 20 with mediorenal wedge resection of the kidney. Hemostatic sutures, FG, and FG with a muscle 'cup' in animals with polar resection of the kidney were compared. FG and sutures in animals with the wedge resection of the kidney were studied as well. Bleeding, hot ischemia time, complication rate, and additional scarring were also analyzed.
  
  
  RESULTS
  Suture hemostasis is safe but with significant adverse effects in both polar and wedge resection of kidney. FG was not efficient as a sole hemostatic agent for polar resection. It was as efficient as hemostatic suture for wedge resection of the kidney. FG with a muscle 'cup' on a pole of the kidney achieved good results in animals with polar resection of the kidney. Histological analysis confirmed better results with FG because of both the less intense and smaller area of additional scarring.
  
  
  CONCLUSIONS
  FG is a reliable and efficient hemostatic agent for nephron-sparing surgery whenever both sided gluing is possible.
authors.affiliation: Clinic of Urology, Clinical Center Nis, Nis, Serbia and Montenegro.
authors.forename: Ivica
authors.initials: I
authors.lastname: Stojkovic
authors.forename: Vojin
authors.initials: V
authors.lastname: Savic
authors.forename: Milan
authors.initials: M
authors.lastname: Djokic
authors.forename: Bela
authors.initials: B
authors.lastname: Balint
authors.forename: Slobodan
authors.initials: S
authors.lastname: Ljubenovic
authors.forename: Ivan
authors.initials: I
authors.lastname: Ignjatovic
mesh_terms: D000287:Administration, Topical; D000818:Animals; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage*; D006488:Hemostasis, Surgical / Q000379:methods; D006490:Hemostatics / Q000008:administration & dosage*; D023421:Models, Animal; D009392:Nephrectomy / Q000009:adverse effects / Q000379:methods*; D011446:Prospective Studies; D013552:Swine
chemical_list: D015718:Fibrin Tissue Adhesive; D006490:Hemostatics