Outcomes of pregnancy complicated by thyroid disease.
OBJECTIVE
To perform a case note review of pregnancies complicated by thyroid dysfunction to determine management and therapeutic intervention in relation to pregnancy outcome.


METHODS
A retrospective case note analysis of 81 ongoing pregnancies in 70 pregnant women with a history of thyroid dysfunction over a period of 5 years at the Glasgow Royal Maternity Hospital (GRMH), Glasgow, Scotland, United Kingdom. The results of thyroid function tests and whether a change in treatment was instituted were recorded. Thyroid function was assessed by standard laboratory reference ranges for free thyroxine (FT4) and thyroid stimulating hormone (TSH) in all trimesters. Other parameters were also noted.


RESULTS
Medication levels needed to be increased in the hypothyroid group (45%), and decreased (38%) in the hyperthyroid group.


CONCLUSIONS
Pregnancy outcome was good in majority of cases given appropriate replacement therapy for stated reference values.
Harborne
Lyndal R
LR
Department of Obstetrics & Gynaecology, Glasgow Royal Infirmary, Glasgow, UK. lyndalharborne@yahoo.co.uk
Alexander
Claire E
CE
Thomson
Andrew J
AJ
O'Reilly
Denis St J
DS
Greer
Ian A
IA
D013956:Antithyroid Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002231:Carbimazole / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005865:Gestational Age; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy* / Q000503:physiopathology; D007037:Hypothyroidism / Q000188:drug therapy* / Q000503:physiopathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy* / Q000503:physiopathology; D011256:Pregnancy Outcome; D011441:Propylthiouracil / Q000008:administration & dosage / Q000627:therapeutic use; D012189:Retrospective Studies; D012307:Risk Factors; D013960:Thyroid Function Tests; D013974:Thyroxine / Q000008:administration & dosage / Q000627:therapeutic use
D013956:Antithyroid Agents; D011441:Propylthiouracil; D002231:Carbimazole; D013974:Thyroxine