title: The value of four mental health self-report scales in predicting interview-based mood and anxiety disorder diagnoses in sibling pairs.
abstract: Questionnaire-based dimensional measures are often employed in epidemiological studies to predict the presence of psychiatric disorders. The present study sought to determine how accurately 4 dimensional mental health measures, the 12-item General Health Questionnaire (GHQ-12), Neuroticism (EPQ-N), the high positive affect and anxious arousal scales from the Mood and Anxiety Symptoms Questionnaire (MASQ-HPA and MASQ-AA) and a composite of all 4, predicted psychiatric caseness as diagnosed by the University of Michigan Composite International Diagnostic Interview (UM-CIDI). Community subjects were recruited through general practitioners; those who agreed to participate were sent a questionnaire containing the above measures. Subsequently, the UM-CIDI was administered by telephone to 469 subjects consisting of sibling pairs who scored most discordantly or concordantly on a composite index of the 4 measures. Logistic Regression and Receiver Operating Characteristic (ROC) curve analyses were carried out to assess the predictive accuracy of the dimensional measures on UM-CIDI diagnosis. A total of 179 subjects, 62 men and 117 women with an average age of 42 years, were diagnosed with at least one of the following psychiatric disorders: depression, dysthymia, generalized anxiety disorder (GAD), social phobia, agoraphobia and panic attack. The six disorders showed high comorbidity. EPQ-N and the Composite Index were found to be very strong and accurate predictors of psychiatric caseness; they were however unable to differentiate between specific disorders. The results from the present study therefore validated the four mental health measures as being predictive of psychiatric caseness.
authors.affiliation: MRC, SGDP, Institute of Psychiatry, King's College London, London, United Kingdom. Richard.williamson@iop.kcl.ac.uk
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Williamson
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: Neale
authors.forename: Abram
authors.initials: A
authors.lastname: Sterne
authors.forename: Martin
authors.initials: M
authors.lastname: Prince
authors.forename: Pak
authors.initials: P
authors.lastname: Sham
mesh_terms: D000328:Adult; D000339:Affect; D000368:Aged; D000369:Aged, 80 and over; D000379:Agoraphobia / Q000175:diagnosis / Q000235:genetics; D001008:Anxiety Disorders / Q000175:diagnosis* / Q000235:genetics; D001143:Arousal; D003863:Depression / Q000175:diagnosis / Q000235:genetics; D019263:Dysthymic Disorder / Q000175:diagnosis / Q000235:genetics; D005260:Female; D005544:Forecasting; D006801:Humans; D007406:Interview, Psychological; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D019964:Mood Disorders / Q000175:diagnosis* / Q000235:genetics; D009497:Neurotic Disorders / Q000175:diagnosis / Q000235:genetics; D016584:Panic Disorder / Q000175:diagnosis / Q000235:genetics; D010555:Personality Inventory; D010698:Phobic Disorders / Q000175:diagnosis / Q000235:genetics; D011237:Predictive Value of Tests; D035781:Siblings