title: Effects of oral estrone on rat energy balance.
abstract: Oral doses of estrone from 10 nmol/(kg day) to 10 micromol/(kg day) were given to adult Wistar male rats for 10 days. Body composition, energy balance, total body estrone balance and plasma metabolites and hormones were measured at the end of the treatment. Body weight (as well as food intake, body energy, fat and water accrual) increased at doses in the 10--100 nmol/(kg day) range, but decreased at higher doses. Energy expenditure decreased with increasing doses of estrone. Plasma metabolite changes suggested the maintenance of energy homeostasis, and lipid parameters indicated that lipid mobilization increased with the increasing doses of estrone. Plasma estrone, acyl-estrone and estradiol levels decreased at low doses and increased at high doses of estrone. We conclude that: (a) repeated estrone gavages, even at very high doses, do not result in the accrual of estrone in the body; (b) low doses of estrone promote growth and high doses decrease body mass and fat accretion; (c) administration of estrone at low doses decreases its circulating levels and the levels of estradiol and acyl-estrone, a situation reverted at higher doses and (d) estrone administration induces a dose-dependent shift towards lower energy expenditure.
authors.affiliation: Department of Nutrition and Food Science, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Ferrer-Lorente
authors.forename: Beatriz
authors.initials: B
authors.lastname: García-Peláez
authors.forename: Susana
authors.initials: S
authors.lastname: Gómez-Ollés
authors.forename: José-Antonio
authors.initials: JA
authors.lastname: Fernández-López
authors.forename: Xavier
authors.initials: X
authors.lastname: Remesar
authors.forename: Marià
authors.initials: M
authors.lastname: Alemany
mesh_terms: D020155:3-Hydroxybutyric Acid / Q000097:blood; D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000032:analysis; D001823:Body Composition / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004305:Dose-Response Relationship, Drug; D002149:Energy Intake / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects*; D004970:Estrone / Q000493:pharmacokinetics / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006728:Hormones / Q000097:blood; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D008076:Cholesterol, HDL; D005230:Fatty Acids, Nonesterified; D006728:Hormones; D014280:Triglycerides; D004970:Estrone; D002784:Cholesterol; D020155:3-Hydroxybutyric Acid