Pulmonary embolization of microcrystalline cellulose in a lung transplant recipient.
Intravenous injection of drugs that contain insoluble foreign material can lead to pulmonary embolization of the material and can have devastating results, including pulmonary hypertension and death. Most cases are detected after the onset of extensive, irreversible damage, precluding potentially life-saving intervention, or are detected at autopsy. We report here a case of microcrystalline cellulose embolization in a lung transplant recipient detected at routine transbronchial biopsy, and we describe the circumstances associated with the development of this condition and its clinical outcome.
Fields
Timothy A
TA
Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA.
McCall
Shannon J
SJ
Reams
B Diane
BD
Roggli
Victor L
VL
Palmer
Scott M
SM
Howell
David N
DN
D000328:Adult; D001706:Biopsy; D002482:Cellulose / Q000008:administration & dosage / Q000009:adverse effects*; D003550:Cystic Fibrosis / Q000601:surgery; D005079:Excipients / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008168:Lung / Q000473:pathology*; D016040:Lung Transplantation; D011655:Pulmonary Embolism / Q000139:chemically induced* / Q000473:pathology
D005079:Excipients; D002482:Cellulose; C109691:microcrystalline cellulose