Synthesis of constrained helical peptides by thioether ligation: application to analogs of gp41.
We present a straightforward and high yielding method to synthesize constrained helical peptides via thioether ligation; this method represents an attractive alternative to the formation of lactam bridge constraints to induce helicity in peptides.
Brunel
Florence M
FM
The Scripps Research Institute, Department of Chemistry and Cell Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Dawson
Philip E
PE
D003500:Cyclization; D015700:HIV Envelope Protein gp41 / Q000737:chemistry*; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D013440:Sulfides / Q000138:chemical synthesis*
D015700:HIV Envelope Protein gp41; D009842:Oligopeptides; D013440:Sulfides