The effect of short-term indomethacin therapy on amniotic fluid volume.
OBJECTIVE
The purpose of this study was to determine the effect of short-term (48 hour) indomethacin therapy on amniotic fluid volume.


METHODS
Patients who were admitted to Northwestern Memorial Hospital in preterm labor and who received indomethacin tocolysis were eligible for the study. Thirty-five patients with singleton gestations and 26 patients with twin gestations were enrolled. Amniotic fluid volumes were measured at baseline, at 48 hours after the initiation of indomethacin, and then every 24 hours thereafter for a maximum of 7 days.


RESULTS
There were no significant changes in mean amniotic fluid volume subsequent to the administration of indomethacin at any of the time points that were measured. Among the 61 patients who received indomethacin, there were 2 cases of oligohydramnios (3.3%; 95% CI, 0.03%, 11.3%). In both cases, the amniotic fluid index returned to normal within 24 hours after the discontinuation of indomethacin.


CONCLUSIONS
Short-term indomethacin therapy, in either singleton or twin gestations, does not cause a clinically significant change in amniotic fluid volume.
Sandruck
Julie C
JC
Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, Ill, USA.
Grobman
William A
WA
Gerber
Susan E
SE
D000653:Amniotic Fluid / Q000187:drug effects* / Q000378:metabolism*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D015994:Incidence; D007213:Indomethacin / Q000008:administration & dosage* / Q000009:adverse effects* / Q000627:therapeutic use; D007752:Obstetric Labor, Premature / Q000188:drug therapy*; D016104:Oligohydramnios / Q000139:chemically induced / Q000453:epidemiology / Q000378:metabolism; D011247:Pregnancy; D011272:Pregnancy, Multiple; D013997:Time Factors; D015149:Tocolytic Agents / Q000008:administration & dosage* / Q000009:adverse effects* / Q000627:therapeutic use; D016896:Treatment Outcome; D014427:Twins
D015149:Tocolytic Agents; D007213:Indomethacin