title: Hemodynamic observations in two pulmonary hypertensive patients changing treatment from inhaled iloprost to the oral endothelin-antagonist bosentan.
abstract: Two female patients with pulmonary arterial hypertension and a permanently implanted hemodynamic monitor changed treatment from inhaled iloprost to oral bosentan. The hemodynamic changes were seen very early after the first dose of bosentan and there was no need to re-establish inhaled iloprost.
authors.affiliation: Department of Medicine, Division of Cardiology, Medical University, Graz, Austria. friedrich.fruhwald@meduni-graz.at
authors.forename: Friedrich M
authors.initials: FM
authors.lastname: Fruhwald
authors.forename: Barbro
authors.initials: B
authors.lastname: Kjellström
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Perthold
authors.forename: Manfred
authors.initials: M
authors.lastname: Wonisch
authors.forename: Robert
authors.initials: R
authors.lastname: Maier
authors.forename: Werner
authors.initials: W
authors.lastname: Klein
mesh_terms: D000280:Administration, Inhalation; D000284:Administration, Oral; D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D000077300:Bosentan; D065128:Endothelin Receptor Antagonists; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000503:physiopathology*; D016285:Iloprost / Q000008:administration & dosage*; D008875:Middle Aged; D018670:Monitoring, Ambulatory / Q000295:instrumentation; D019736:Prostheses and Implants; D013449:Sulfonamides / Q000008:administration & dosage*
chemical_list: D000959:Antihypertensive Agents; D065128:Endothelin Receptor Antagonists; D013449:Sulfonamides; D016285:Iloprost; D000077300:Bosentan