title: Optical biopsy of breast tissue using differential path-length spectroscopy.
abstract: Differential path-length spectroscopy (DPS) was used to determine the local optical properties of breast tissue in vivo. DPS measurements were made on healthy and malignant breast tissue using a fibre-optic needle probe, and were correlated to the histological outcome of core-needle biopsies taken from the same location as the measurements. DPS yields information on the local tissue blood content, the local blood oxygenation, the average micro-vessel diameter, the beta-carotene concentration and the scatter slope. Our data show that malignant breast tissue is characterized by a significant decrease in tissue oxygenation and a higher blood content compared to normal breast tissue.
authors.affiliation: Department of Radiation Oncology, Center for Optical Diagnostics and Therapy, Erasmus Medical Center Rotterdam, PO Box 5201, 3008 AE Rotterdam, The Netherlands.
authors.forename: Robert L P
authors.initials: RL
authors.lastname: van Veen
authors.forename: Arjen
authors.initials: A
authors.lastname: Amelink
authors.forename: Marian
authors.initials: M
authors.lastname: Menke-Pluymers
authors.forename: Carmen
authors.initials: C
authors.lastname: van der Pol
authors.forename: Henricus J C M
authors.initials: HJ
authors.lastname: Sterenborg
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle / Q000295:instrumentation; D001940:Breast / Q000098:blood supply / Q000378:metabolism / Q000473:pathology; D001943:Breast Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D005240:Feasibility Studies; D005260:Female; D005336:Fiber Optic Technology / Q000295:instrumentation*; D006801:Humans; D008875:Middle Aged; D013057:Spectrum Analysis / Q000295:instrumentation / Q000379:methods