Is NF-kappaB a culprit in type 2 diabetes?
It has been generally viewed that salicylates ameliorate type 2 diabetes through interfering with the NF-kappaB signaling. Earlier studies indicated that IKKbeta was the key for the development of insulin resistance. However, it was unknown whether IKKbeta itself, or its downstream target, NF-kappaB, plays major roles in insulin resistance. New data suggest that NF-kappaB and NF-kappaB-regulated cytokines are crucial for the diabetogenesis.
Chen
Fei
F
The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. fchen@cdc.gov
D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism*
D016328:NF-kappa B