title: Estradiol administration mediates the inflammatory response to formalin in female rats.
abstract: Female rats demonstrate higher pain sensitivity than do males in various nociceptive assays of inflammation. In the present study, we found that estradiol (20%) replacement in ovariectomized rats attenuated the chronic phase of the formalin response but only at high formalin concentrations thought to rely on peripheral inflammation. An inactive isomer of estradiol, alpha-estradiol, failed to result in the same attenuation (P > 0.05). Our results suggest that estradiol's actions in inflammatory responses are mediated through genomic estrogen receptor-mediated mechanisms.
authors.affiliation: Department of Psychology, Biopsychology Subprogram, Hunter College, The City University of New York, 695 Park Avenue, New York, NY 10021, USA.
authors.forename: Tzipora
authors.initials: T
authors.lastname: Kuba
authors.forename: Lynne M
authors.initials: LM
authors.lastname: Kemen
authors.forename: Vanya
authors.initials: V
authors.lastname: Quinones-Jenab
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000097:blood / Q000494:pharmacology*; D004195:Disease Models, Animal; D004967:Estrogens / Q000097:blood / Q000494:pharmacology*; D030762:Estrous Cycle / Q000502:physiology*; D005260:Female; D007249:Inflammation / Q000139:chemically induced / Q000378:metabolism*; D008597:Menstrual Cycle / Q000378:metabolism; D009475:Neurons, Afferent / Q000502:physiology; D010052:Ovariectomy; D010146:Pain / Q000378:metabolism* / Q000503:physiopathology; D010147:Pain Measurement; D017288:Pain Threshold / Q000187:drug effects* / Q000502:physiology; D010525:Peripheral Nerves / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011960:Receptors, Estrogen / Q000819:agonists / Q000378:metabolism; D012727:Sex Characteristics
chemical_list: D000893:Anti-Inflammatory Agents; D004967:Estrogens; D011960:Receptors, Estrogen