Anxiolytic suppression of repetitive transcranial magnetic stimulation-induced anxiety in the rats.
Repetitive transcranial magnetic stimulation (rTMS) is effective for treatment of several psychiatric disorders such as depression and anxiety disorder. However, some reports suggest that rTMS induced anxiety in normal volunteers. Consistent with this observation, we have reported that chronic rTMS induces anxiety in normal rats which was suppressed by chronic treatment, but not acute paroxetine treatment. The current study evaluates rTMS as animal model of anxiety by investigating the effect of rTMS on anxiety behaviors and the ability of standard anxiolytics to block expression of these behaviors. We found that 10-day rTMS induced anxiety in normal rats, as evidenced by expression of anxiety behaviors in the elevated plus-maze. This anxiety was suppressed by acute treatment with diazepam, alprazolam, or buspirone suggesting that chronic rTMS treatment provides a good animal model for anxiety.
Isogawa
Koichi
K
Department of Neuropsychiatry, Oita University Faculty of Medicine, Oita 879-5593, Japan.
Fujiki
Minoru
M
Akiyoshi
Jotaro
J
Tsutsumi
Takashi
T
Kodama
Kensuke
K
Matsushita
Hirotaka
H
Tanaka
Yoshihiro
Y
Kobayashi
Hidenori
H
D000161:Acoustic Stimulation; D000525:Alprazolam / Q000627:therapeutic use; D000818:Animals; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy / Q000209:etiology / Q000523:psychology*; D002065:Buspirone / Q000627:therapeutic use; D003975:Diazepam / Q000627:therapeutic use; D004574:Electromagnetic Fields / Q000009:adverse effects*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
D014151:Anti-Anxiety Agents; D003975:Diazepam; D002065:Buspirone; D000525:Alprazolam