Role of NK cells in mismatched unrelated haematopoietic stem-cell transplantation: fact or fiction?
The role of alloreactive NK cells in haematopoietic stem-cell transplantation is a controversial topic. Different studies come up with different conclusions. This is mainly due to heterogeneous patient populations, differences in the sources of haematopoietic stem cells and various conditioning regimens. International collaboration is essential to reveal in which situation NK cell alloreactivity plays a role and, if so, whether it is beneficial or detrimental for patient survival.
Claas
F H J
FH
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2300 RC Leiden, the Netherlands. fhjclaas@lumc.nl
Oudshoorn
M
M
D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006650:Histocompatibility Testing; D006801:Humans; D007391:International Cooperation; D007694:Killer Cells, Natural / Q000166:cytology*; D011971:Receptors, Immunologic / Q000502:physiology; D054340:Receptors, KIR; D019172:Transplantation Conditioning; D016896:Treatment Outcome
D011971:Receptors, Immunologic; D054340:Receptors, KIR