[Training and extinction of passive avoidance in mice lacking monoamine oxidase A].
The passive avoidance learning and memory trace retention in mice lacking monoamine oxidase A (MAO A) and control C3H strain were analyzed. It is shown that mice of both strains were well the passive avoidance learners. A delay of the memory trace extinction was found in lacking MAO A mice as compared with control C3H strain. Mice with a genetic MAO A knockout showed decreased amounts of transitions, rearings, looking to a dark compartment and appearing from it. These findings seem to reflect more expressed fear reaction to a dangerous compartment and increased anxiety promoting longer retention of memory trace on a high level of retrieval.
Dubrovina
N I
NI
Popova
N K
NK
Gilinskiĭ
M A
MA
Tomilenko
R A
RA
Seĭf
I
I
D000818:Animals; D001522:Behavior, Animal; D004924:Escape Reaction; D005108:Extinction, Psychological; D007858:Learning; D008568:Memory / Q000502:physiology*; D051379:Mice; D008809:Mice, Inbred C3H; D008995:Monoamine Oxidase / Q000172:deficiency* / Q000235:genetics*; D012153:Retention, Psychology; D013663:Teaching / Q000379:methods*
D008995:Monoamine Oxidase