Stent implantation, but not pathogen burden, is associated with plasma C-reactive protein and interleukin-6 levels after percutaneous coronary intervention in patients with stable angina pectoris.
BACKGROUND
The systemic inflammatory response to percutaneous coronary intervention (PCI) is associated with recurrent cardiac events; however, the pathophysiology of this inflammatory response is not well understood. The present study was performed to investigate the role of pathogen burden of infection in determining the magnitude of C-reactive protein (CRP) and interleukin 6 (IL-6) response to PCI.


METHODS
One hundred patients with stable angina pectoris undergoing elective PCI at a single center were recruited. Antibodies against cytomegalovirus, Chlamydia pneumoniae , Epstein-Barr virus, Helicobacter pylori , and herpes simplex virus types 1 and 2 were determined before PCI. Plasma CRP and IL-6 levels were measured before and 6, 24, 48, 72 hours after PCI and data presented as area under the curve.


RESULTS
Plasma CRP and IL-6 concentrations increased significantly after PCI. Neither antibodies against single nor multiple pathogens were associated with the CRP or IL-6 response to PCI. No correlations were found between the inflammatory markers and troponin T levels after PCI. With the exception for CRP and body mass index (R = 0.20, P < .05), neither risk factors for coronary heart disease nor medication but stent implantation was associated with increased plasma CRP (76 vs 61 mg/L, P < .005) and IL-6 (74 vs 64 pg/mL, P < .005) levels after PCI.


CONCLUSIONS
Stent implantation, but not pathogen burden, is associated with the plasma CRP and IL-6 response to PCI.
Saleh
Nawsad
N
Department of Cardiology, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden. nawsad.saleh@ks.se
Svane
Bertil
B
Jensen
Jens
J
Hansson
Lars-Olof
LO
Nordin
Margareta
M
Tornvall
Per
P
D000368:Aged; D000787:Angina Pectoris / Q000097:blood* / Q000382:microbiology* / Q000628:therapy; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D019540:Area Under Curve; D002097:C-Reactive Protein / Q000378:metabolism*; D023903:Coronary Restenosis / Q000209:etiology; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015607:Stents / Q000009:adverse effects*; D020107:Troponin T / Q000097:blood
D015850:Interleukin-6; D020107:Troponin T; D002097:C-Reactive Protein