title: [Chronic obstructive pulmonary disease (COPD): expression of a chronic inflammatory reaction].
abstract: Our understanding of chronic inflammation in COPD has been profoundly changed as a result of findings which suggest that airway inflammation in COPD consists not only of a chronic cellular inflammatory reaction dominated by lymphocytes and neutrophil granulocytes, but also of an intensified secondary wound healing reaction. Unfortunately, little is known about the impact of both reactions on the maintenance of chronic airway inflammation in COPD. Systematic biological evaluation under clinical circumstances will be necessary in order to realize new therapeutic options in COPD.
authors.affiliation: Klinische Abteilung für Pulmologie. Universitätsklinik für Innere Medizin IV, Wien, Osterreich. rolf.ziesche@meduniwien.ac.at
authors.forename: Rolf
authors.initials: R
authors.lastname: Ziesche
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D018836:Inflammation Mediators / Q000378:metabolism / Q000502:physiology; D008168:Lung / Q000378:metabolism; D008214:Lymphocytes / Q000276:immunology / Q000502:physiology; D009504:Neutrophils / Q000276:immunology / Q000502:physiology; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology*; D011658:Pulmonary Fibrosis / Q000175:diagnosis / Q000503:physiopathology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012907:Smoking / Q000503:physiopathology; D014158:Transcription, Genetic; D014945:Wound Healing / Q000502:physiology
chemical_list: D018836:Inflammation Mediators