Extraction of dielectric properties of multiple populations from dielectrophoretic collection spectrum data.
In this paper we show how simplifying assumptions can be used to extract useful data from the dielectrophoretic collection spectrum, in particular for the cytoplasm, and hence determine the properties of multiple populations of cells within a sample. Specifically, the observation of the frequencies of onset of dielectric dispersion allows the identification and enumeration of populations of cells according to cytoplasmic conductivity, with particular relevance to the determination of the action of drugs for high-throughput screening applications.
Broche
Lionel M
LM
Centre for Biomedical Engineering, School of Engineering, University of Surrey, Guildford, Surrey GU2 7XH, UK.
Labeed
Fatima H
FH
Hughes
Michael P
MP
D000465:Algorithms; D000818:Animals; D002452:Cell Count / Q000379:methods*; D002468:Cell Physiological Phenomena / Q000528:radiation effects*; D002469:Cell Separation / Q000379:methods*; D003198:Computer Simulation; D004586:Electrophoresis / Q000379:methods*; D005434:Flow Cytometry / Q000379:methods*; D006801:Humans; D008954:Models, Biological