title: Transfer of an avian genetic reflex epilepsy by embryonic brain graft: a tissue autonomous process?
abstract: Electroencephalographic characteristics and clinical symptoms of an avian genetic reflex epilepsy have been transferred from Fayoumi epileptic (Fepi) chickens to non-epileptic chickens by embryonic homotopic grafts of brain neuroepithelium. Transplanted tissues belonging to the prosencephalic vesicle transferred epileptic electrical features while tissues from the mesencephalic vesicle were responsible for seizure motor manifestations of the disease. Thus each of these tissues can express their own specificity when grafted separately in a normal host, but they co-operate to produce the complete epileptic phenotype when grafted together.
authors.affiliation: Laboratoire d'Embryologie Cellulaire et Moléculaire, CNRS UMR 7128, Nogent-sur-Marne, France. marie-aimee.teillet@college-de-France.fr
authors.forename: Marie-Aimée
authors.initials: MA
authors.lastname: Teillet
authors.forename: Robert
authors.initials: R
authors.lastname: Naquet
authors.forename: Cesira
authors.initials: C
authors.lastname: Batini
mesh_terms: D000818:Animals; D016380:Brain Tissue Transplantation / Q000379:methods* / Q000502:physiology; D002642:Chick Embryo; D002645:Chickens; D004195:Disease Models, Animal; D004569:Electroencephalography; D020195:Epilepsy, Reflex / Q000503:physiopathology / Q000628:therapy*; D016332:Fetal Tissue Transplantation; D010641:Phenotype; D011784:Quail; D018183:Transplantation Chimera; D014183:Transplantation, Heterologous / Q000379:methods