title: Management options to reduce exposure to methyl mercury through the consumption of fish and fishery products by the French population.
abstract: This paper presents an updated assessment of exposure in France to methyl mercury through the consumption of fish and fishery products, and proposes several management scenarios which could reduce this exposure through changes to fish contamination levels or fish consumption patterns. The exposure model was applied in line with previous methodological results [Tressou, J., Crépet, A., Bertail, P., Feinberg, M.H., Leblanc J.Ch., 2004a. Probabilistic exposure assessment to food chemicals based on extreme value theory: application to heavy metals from fish and sea products. Food Chem. Toxicol. 42, 1349-1358; Tressou, J., Leblanc, J.Ch., Feinberg, M., Bertail, P., 2004b. Statistical methodology to evaluate food exposure to a contaminant and influence of sanitary limits: application to ochratoxin A. Regul. Toxicol. Pharmacol. 40, 252-263] so as to obtain a realistic estimate of probability and confidence intervals (95% CI) concerning French consumers exposed to levels exceeding the revised fixed provisional tolerable weekly intake (PTWI) for methyl mercury of 1.6 microg/week/kg of body weight, established by the Joint FAO/WHO Expert Committee on Food Additives in 2003. The results showed that young children aged between 3 and 6 years old or 7 and 10 years old, and women of childbearing age were at the risk groups. With respect to these groups and according to the fish consumers patterns (consumers of predatory fish only or consumers of predatory and nonpredatory fish), the results suggested that strategies to diminish MeHg exposure by reducing the amount of predatory fish consumed would be more efficient in significantly decreasing the probability of exceeding the PTWI than the implementation of international standards.
authors.affiliation: INRA Mét@risk, Food risk analysis methodologies, 16 rue Claude Bernard, 75231 Paris, Cedex 5, France. crepet@inapg.inra.fr
authors.forename: A
authors.initials: A
authors.lastname: Crépet
authors.forename: J
authors.initials: J
authors.lastname: Tressou
authors.forename: P
authors.initials: P
authors.lastname: Verger
authors.forename: J Ch
authors.initials: JCh
authors.lastname: Leblanc
mesh_terms: D000293:Adolescent; D000328:Adult; D000465:Algorithms; D002648:Child; D002675:Child, Preschool; D005247:Feeding Behavior; D005260:Female; D005506:Food Contamination / Q000517:prevention & control; D005517:Foodborne Diseases / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D008630:Mercury Poisoning / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D008875:Middle Aged; D018570:Risk Assessment / Q000379:methods / Q000706:statistics & numerical data; D017747:Seafood / Q000506:poisoning*