title: Evidence for substantial genetic risk for psychopathy in 7-year-olds.
abstract: BACKGROUND
  Individuals with early warning signs of life-long psychopathy, callous-unemotional traits (CU) and high levels of antisocial behaviour (AB) can be identified in childhood. We report here the first twin study of high levels of psychopathic tendencies in young children.
  
  
  METHODS
  At the end of the first school year, teachers provided ratings of CU and AB for 3687 twin pairs from the Twins Early Development Study (TEDS). For the analyses of extreme CU, we selected same-sex twin pairs where at least one twin scored 1.3 or more standard deviations above the mean on the CU scale (612 probands, 459 twin pairs). For the analysis of extreme AB, we selected same-sex twin pairs where at least one twin scored 1.3 or more standard deviations above the mean on AB scale (444 probands, 364 twin pairs). Furthermore, the extreme AB sample was divided into those who were also extreme on CU (children with psychopathic tendencies; 234 probands, 187 twin pairs) and those who did not score in the extreme for CU (children without psychopathic tendencies; 210 probands, 177 twin pairs).
  
  
  RESULTS
  DeFries-Fulker extremes analysis indicated that exhibiting high levels of CU is under strong genetic influence. Furthermore, separating children with AB into those with high and low levels of CU showed striking results: AB in children with high levels of CU is under extremely strong genetic influence and no influence of shared environment, whereas AB in children with low levels of CU shows moderate genetic and shared environmental influence.
  
  
  CONCLUSIONS
  The remarkably high heritability for CU, and for AB children with CU, suggests that molecular genetic research on antisocial behaviour should focus on the CU core of psychopathy. Our findings also raise questions for public policy on interventions for antisocial behaviour.
authors.affiliation: Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK. spjgemc@iop.kcl.ac.uk
authors.forename: Essi
authors.initials: E
authors.lastname: Viding
authors.forename: R James R
authors.initials: RJ
authors.lastname: Blair
authors.forename: Terrie E
authors.initials: TE
authors.lastname: Moffitt
authors.forename: Robert
authors.initials: R
authors.lastname: Plomin
mesh_terms: D000987:Antisocial Personality Disorder / Q000235:genetics* / Q000523:psychology; D002648:Child; D004644:Emotions; D004777:Environment; D006801:Humans; D012044:Regression Analysis; D014429:Twins, Dizygotic / Q000523:psychology*; D014430:Twins, Monozygotic / Q000523:psychology*