Structure of msj-1 gene: a comparative analysis.
Msj-1 gene encodes a DnaJ protein highly expressed in spermatids and spermatozoa of both rodents and amphibians. We isolated and characterized the msj-1 gene in mice. A bioinformatic approach was then used to predict the putative promoter region, chromosomal localization, and its presence in the human genome. The analysis of msj-1 genomic sequence revealed that msj-1 is an intronless gene. Interestingly, two regions (A and B, separated by 10,682 bp) on human chromosome 2 having respectively 78% and 77% nucleotide identity with the murine msj-1 coding region were identified. This suggests the existence of an msj-1-like gene also in humans.
Meccariello
R
R
Department of Experimental Medicine, Second University of Naples, Italy.
Tedeschi
G
G
Monsurrò
M R
MR
Chianese
R
R
Cobellis
G
G
Pierantoni
R
R
Fasano
S
S
D000818:Animals; D050956:HSP40 Heat-Shock Proteins / Q000737:chemistry* / Q000235:genetics*; D051379:Mice; D011401:Promoter Regions, Genetic / Q000235:genetics
C494642:Dnajb3 protein, mouse; D050956:HSP40 Heat-Shock Proteins