Phosphorylated 14-3-3zeta protein in the CSF of neuroleptic-treated patients.
The authors describe 12 neuroleptic-treated patients with dementia of various etiologies who showed CSF elevation of phosphorylated 14-3-3zeta and normal tau protein levels. This contrasted with elevated amounts of 14-3-3 gamma, epsilon, and unphosphorylated zeta coupled to high tau protein levels in Creutzfeldt-Jakob disease and negative 14-3-3 assay in drug-free patients with dementia. Characterization of CSF 14-3-3 isoforms and determination of tau protein level can help to distinguish different etiologies of dementia.
Zanusso
G
G
Department of Neurological and Visual Sciences, University of Verona, Verona, Italy.
Fiorini
M
M
Farinazzo
A
A
Gelati
M
M
Benedetti
M D
MD
Ferrari
S
S
Dalla Libera
A
A
Capaldi
S
S
Monaco
H L
HL
Rizzuto
N
N
Monaco
S
S
D048948:14-3-3 Proteins / Q000134:cerebrospinal fluid*; D000368:Aged; D000369:Aged, 80 and over; D014150:Antipsychotic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid / Q000175:diagnosis; D003704:Dementia / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000188:drug therapy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010766:Phosphorylation; D011237:Predictive Value of Tests; D020033:Protein Isoforms / Q000134:cerebrospinal fluid; D012016:Reference Values; D015854:Up-Regulation / Q000502:physiology; D016875:tau Proteins / Q000134:cerebrospinal fluid*
D048948:14-3-3 Proteins; D014150:Antipsychotic Agents; D015415:Biomarkers; D020033:Protein Isoforms; D016875:tau Proteins