title: Combined radical prostatectomy and bladder augmentation for concomitant prostate cancer and detrusor instability.
abstract: OBJECTIVE
  To determine the outcomes of a select cohort of patients with severe voiding dysfunction, refractory to medical management, and a concomitant diagnosis of prostate cancer, who were treated with radical prostatectomy and augmentation enterocystoplasty.
  
  
  METHODS
  Four men with biopsy-proven prostatic adenocarcinoma, as well as a diagnosis of severe overactive bladder, underwent combined radical retropubic prostatectomy and augmentation enterocystoplasty. All patients underwent fluorourodynamic testing confirming nonobstructive detrusor instability or hyperreflexia. Three patients underwent nerve-sparing radical retropubic prostatectomy with a clamshell ileocystoplasty, and one with neurogenic hyperreflexia underwent sigmoid cystoplasty with a continent catheterizable stoma at radical retropubic prostatectomy.
  
  
  RESULTS
  The mean follow-up was 21.5 months (range 8 to 48). All patients had an undetectable prostate-specific antigen level postoperatively. The average hospitalization was 8 days. Perioperative complications occurred in 2 patients, including a prolonged urine leak managed with catheter drainage and postoperative hematuria requiring cystoscopic clot evacuation. Erectile function was preserved in 2 patients with good preoperative erections. At last follow-up, the 3 patients who voided per urethra had minimal postvoid residual urine volumes and maintained good continence, with only 1 patient describing occasional mild stress incontinence. At last follow-up, the patient with the sigmoid cystoplasty catheterized every 4 hours with volumes of about 300 mL and complete stomal continence. No patient required anticholinergic medications postoperatively.
  
  
  CONCLUSIONS
  The concomitant diagnosis of prostate cancer and severe detrusor instability may be difficult to treat. The results of our study have shown that for those desiring surgical management for their prostate cancer, a combined bladder augmentation and radical prostatectomy may be performed with minimal added morbidity and significantly improved voiding function in the properly selected individual.
authors.affiliation: Department of Urology, University of Southern California Keck School of Medicine and Norris Comprehensive Cancer Center, Los Angeles, California 90089, USA. quekm@hsc.usc.edu
authors.forename: Marcus L
authors.initials: ML
authors.lastname: Quek
authors.forename: Piers
authors.initials: P
authors.lastname: Barry
authors.forename: John P
authors.initials: JP
authors.lastname: Stein
authors.forename: Gary
authors.initials: G
authors.lastname: Lieskovsky
authors.forename: David A
authors.initials: DA
authors.lastname: Ginsberg
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000601:surgery*; D000368:Aged; D006801:Humans; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000150:complications / Q000601:surgery*; D001743:Urinary Bladder / Q000601:surgery*; D001745:Urinary Bladder Diseases / Q000150:complications / Q000601:surgery*; D014555:Urination Disorders / Q000209:etiology / Q000601:surgery