Prime-boost immunisation strategies for tuberculosis.
Vaccines against intracellular pathogens such as Mycobacterium tuberculosis need to induce strong cellular immune responses. Heterologous prime-boost immunisation strategies induce higher levels of both CD4+ and CD8+ T cells than homologous boosting with the same vector. Recombinant pox-viruses are particularly good at boosting previously primed T cell responses. Using BCG as the priming immunisation in such a heterologous prime-boost strategy is a practical solution, which allows the beneficial effects of BCG in children to be maintained.
McShane
Helen
H
Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK. helen.mcshane@ndm.ox.ac.uk
Hill
Adrian
A
D006801:Humans; D007115:Immunization Schedule; D007117:Immunization, Secondary; D032581:Tuberculosis Vaccines / Q000008:administration & dosage*
D032581:Tuberculosis Vaccines