Heritability of substance dependence in a native American population.
OBJECTIVE
To estimate the heritability of substance dependence and associated symptoms in a sample of Southwest California (Mission) Indians.


METHODS
Families from eight contiguous Indian reservations were recruited in order to ascertain information on substance dependence symptoms and diagnoses using a semi-structured diagnostic interview. Dependence diagnoses for alcohol, marijuana, stimulants and a measure of regular tobacco usage, any drug dependence or tobacco usage were obtained. Composite measures of alcohol dependence symptoms for withdrawal, drinking severity, antisocial problems and interpersonal problems were constructed from the nine groups of symptoms summarized in the diagnostic interview. Heritability estimates were calculated using variance component methods, as implemented in SOLAR.


RESULTS
In this population, marijuana dependence (0.38) and regular tobacco use (0.43), alcohol dependence (DSM-III-R 0.19; ICD-10, 0.29) and stimulant dependence (0.25) showed evidence for moderate genetic influences as determined by heritability estimates. Four phenotypes constructed using the composite symptoms of alcohol dependence revealed that withdrawal had the highest heritability estimate (0.71), followed by antisocial problems (0.36) and drinking severity (0.34). Symptom clusters reflecting interpersonal problems did not appear to be highly heritable (0.19).


CONCLUSIONS
Marijuana dependence, regular tobacco usage and composite phenotypes constructed from alcohol dependence symptoms for antisocial problems, drinking severity and withdrawal generally have patterns of familial aggregation, suggesting that they can be successfully used for linkage analysis in this Southwest California Indian sample.
Wilhelmsen
Kirk C
KC
Department of Neurology, University of California, San Francisco, CA, USA. kirk@egcrc.net
Ehlers
Cindy
C
D000428:Alcohol Drinking / Q000235:genetics; D002140:California; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D002189:Marijuana Abuse / Q000235:genetics; D010375:Pedigree; D012907:Smoking / Q000235:genetics; D013375:Substance Withdrawal Syndrome / Q000235:genetics; D019966:Substance-Related Disorders / Q000235:genetics*