title: The mammalian Mediator complex and its role in transcriptional regulation.
abstract: Mediator is an essential component of the RNA polymerase II general transcriptional machinery and plays a crucial part in the activation and repression of eukaryotic mRNA synthesis. The Saccharomyces cerevisiae Mediator was the first to be defined and is a high molecular mass complex composed of >20 distinct subunits that performs multiple activities in transcription. Recent studies have defined the subunit composition and associated activities of mammalian Mediator, and revealed a striking evolutionary conservation of Mediator structure and function from yeast to man.
authors.affiliation: Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Conaway
authors.forename: Shigeo
authors.initials: S
authors.lastname: Sato
authors.forename: Chieri
authors.initials: C
authors.lastname: Tomomori-Sato
authors.forename: Tingting
authors.initials: T
authors.lastname: Yao
authors.forename: Joan W
authors.initials: JW
authors.lastname: Conaway
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D046912:Multiprotein Complexes; D021122:Protein Subunits / Q000235:genetics / Q000378:metabolism*; D012319:RNA Polymerase II / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D046912:Multiprotein Complexes; D021122:Protein Subunits; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D012319:RNA Polymerase II