The effect of ketoconazole on the pharmacokinetics of a selective alpha 1A-adrenoceptor antagonist.
Winchell
Gregory A
GA
Merck Research Laboratories, PO Box 4, West Point, PA 19486, USA.
Mistry
Goutam C
GC
Kari
Prasad P
PP
Marbury
Thomas
T
Miller
Jutta L
JL
Simpson
Richard C
RC
Rodrigues
A David
AD
Gottesdiener
Keith M
KM
Wagner
John A
JA
D000284:Administration, Oral; D058668:Adrenergic alpha-1 Receptor Antagonists; D000328:Adult; D019540:Area Under Curve; D002250:Carbon Radioisotopes; D003374:Coumarins / Q000494:pharmacology; D018592:Cross-Over Studies; D051544:Cytochrome P-450 CYP3A; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000378:metabolism; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D000077604:Fomepizole; D006207:Half-Life; D006801:Humans; D007654:Ketoconazole / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D011720:Pyrazoles / Q000494:pharmacology; D011744:Pyrimidinones / Q000032:analysis / Q000378:metabolism / Q000494:pharmacology; D011802:Quinidine / Q000494:pharmacology; D018340:Receptors, Adrenergic, alpha-1 / Q000008:administration & dosage / Q000627:therapeutic use*; D013426:Sulfaphenazole / Q000494:pharmacology; D013806:Theophylline / Q000031:analogs & derivatives / Q000494:pharmacology
D058668:Adrenergic alpha-1 Receptor Antagonists; D002250:Carbon Radioisotopes; D003374:Coumarins; D065607:Cytochrome P-450 Enzyme Inhibitors; D011720:Pyrazoles; D011744:Pyrimidinones; D018340:Receptors, Adrenergic, alpha-1; D013426:Sulfaphenazole; D000077604:Fomepizole; D003577:Cytochrome P-450 Enzyme System; C030123:coumarin; D013806:Theophylline; C050131:furafylline; C104464:CYP3A protein, human; D051544:Cytochrome P-450 CYP3A; D011802:Quinidine; C420450:L 771688; D007654:Ketoconazole