A new view of an old pore.
Despite reports suggesting a potential role in membrane fusion, the V(0) subunit of the (+)H/ATPase has remained an unlikely candidate for the fusion pore. In this issue of Cell, Hiesinger and coworkers (Hiesinger et al., 2005) present a forward genetic screen that reveals it to be necessary for synaptic vesicle fusion, independent of its role in vesicle acidification.
Bajjalieh
Sandra
S
Department of Pharmacology, University of Washington, D429 HSB, Box 357280, Seattle, Washington 98195. Electronic address: bajjalie@u.washington.edu.
D000818:Animals; D006801:Humans; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D008561:Membrane Fusion / Q000235:genetics; D050600:SNARE Proteins; D013570:Synaptic Membranes / Q000235:genetics / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology; D013572:Synaptic Vesicles / Q000378:metabolism; D025262:Vacuolar Proton-Translocating ATPases / Q000235:genetics / Q000378:metabolism; D033921:Vesicular Transport Proteins / Q000378:metabolism
D029721:Drosophila Proteins; D050600:SNARE Proteins; D025262:Vacuolar Proton-Translocating ATPases; D033921:Vesicular Transport Proteins