Thermal synthesis of nucleoside H-phosphonates under mild conditions.
Nucleosides react rapidly with ammonium phosphite ((NH4)2HPO3) at 60 degrees C to produce good yields of nucleoside-5'-phosphite monoesters within 24 h. Under the same conditions, ammonium phosphate is unreactive, producing low yields of nucleotide only after extended reactions. These results confirm earlier suggestions that nucleoside H-phosphonates and their possible condensation products may have been produced on the primitive earth more easily than nucleotides.
De Graaf
R M
RM
Evolutionary Biology Research Group, Faculty of Science, University of Nijmegen, 6500 GL Nijmegen, The Netherlands.
Schwartz
Alan W
AW
D006358:Hot Temperature; D009682:Magnetic Resonance Spectroscopy; D009705:Nucleosides / Q000737:chemistry; D009711:Nucleotides / Q000138:chemical synthesis*; D063065:Organophosphonates / Q000138:chemical synthesis; D017905:Phosphites / Q000737:chemistry; D010766:Phosphorylation; D014529:Uridine / Q000737:chemistry
D009705:Nucleosides; D009711:Nucleotides; D063065:Organophosphonates; D017905:Phosphites; D014529:Uridine