title: PMUT: a web-based tool for the annotation of pathological mutations on proteins.
abstract: PMUT allows the fast and accurate prediction (approximately 80% success rate in humans) of the pathological character of single point amino acidic mutations based on the use of neural networks. The program also allows the fast scanning of mutational hot spots, which are obtained by three procedures: (1) alanine scanning, (2) massive mutation and (3) genetically accessible mutations. A graphical interface for Protein Data Bank (PDB) structures, when available, and a database containing hot spot profiles for all non-redundant PDB structures are also accessible from the PMUT server.
authors.affiliation: Molecular Modeling and Bioinformatics Unit, Institut de Recerca Biomédica, Parc Científic de Barcelona Josep Samitier 1-5, Barcelona 08028, Spain.
authors.forename: Carles
authors.initials: C
authors.lastname: Ferrer-Costa
authors.forename: Josep Lluis
authors.initials: JL
authors.lastname: Gelpí
authors.forename: Leire
authors.initials: L
authors.lastname: Zamakola
authors.forename: Ivan
authors.initials: I
authors.lastname: Parraga
authors.forename: Xavier
authors.initials: X
authors.lastname: de la Cruz
authors.forename: Modesto
authors.initials: M
authors.lastname: Orozco
mesh_terms: D019943:Amino Acid Substitution; D003198:Computer Simulation; D020407:Internet; D008956:Models, Chemical; D008958:Models, Molecular; D016297:Mutagenesis, Site-Directed; D016571:Neural Networks, Computer; D011506:Proteins / Q000032:analysis / Q000737:chemistry*; D016415:Sequence Alignment / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*; D012984:Software; D014584:User-Computer Interface
chemical_list: D011506:Proteins