Effect of an indwelling nasogastric tube on gastric emptying rates of liquids in horses.
OBJECTIVE
To evaluate the effect of an indwelling nasogastric tube on gastric emptying of liquids in horses.


METHODS
9 healthy adult horses.


METHODS
A randomized block crossover design was used. For treatment group horses, a nasogastric tube was placed and 18 hours later, acetaminophen was administered; the nasogastric tube remained in place until the experiment was complete. For control group horses, a nasogastric tube was passed into t stomach, acetaminophen was administered, and the nasogastric tube was removed immediately. Serial blood samples were collected 15 minutes before and after administration of acetaminophen. Serum concentration of acetaminophen was determined by use of fluorescence polarization immunoassay. The variables, time to maximum acetaminophen concentration (Tmax) and the appearance constant for acetaminophen (Kapp), were determined. The values for Kapp and Tmax in horses with and without prolonged nasogastric tube placement were compared.


RESULTS
No significant difference was found in Kapp between horses with and without prolonged nasogastric tube placement; the median difference in Kapp was 0.01 min(-1) (range, -0.48 to 0.80 min(-1). No significant difference was found in Tmax between horses with and without prolonged nasogastric tube placement; the median difference in Tmax was 5 minutes (range, -30 to 50 minutes). Reanalysis of data following the removal of possible outlier values from 1 horse resulted in a significant difference in Tmax between horses with and without prolonged nasogastric tube placement.


CONCLUSIONS
Although no clinically important impact of 18 hours of nasogastric intubation was found on gastric emptying in healthy was found among horses.
Lammers
Timothy W
TW
Department of Large Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843-4475, USA.
Roussel
Allen J
AJ
Boothe
Dawn M
DM
Cohen
Noah D
ND
D000082:Acetaminophen / Q000097:blood / Q000493:pharmacokinetics; D018712:Analgesics, Non-Narcotic / Q000097:blood / Q000493:pharmacokinetics; D000818:Animals; D018592:Cross-Over Studies; D005260:Female; D016231:Fluorescence Polarization Immunoassay / Q000662:veterinary; D005746:Gastric Emptying / Q000502:physiology*; D006736:Horses / Q000502:physiology*; D007408:Intestinal Absorption; D007441:Intubation, Gastrointestinal / Q000379:methods / Q000662:veterinary*; D008297:Male
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen