Space flight and bone formation.
Major physiological changes which occur during spaceflight include bone loss, muscle atrophy, cardiovascular and immune response alterations. When trying to determine the reason why bone loss occurs during spaceflight, one must remember that all these other changes in physiology and metabolism may also have impact on the skeletal system. For bone, however, the role of normal weight bearing is a major concern and we have found no adequate substitute for weight bearing which can prevent bone loss. During the study of this problem, we have learned a great deal about bone physiology and increased our knowledge about how normal bone is formed and maintained. Presently, we do not have adequate ground based models which can mimic the tissue loss that occurs in spaceflight but this condition closely resembles the bone loss seen with osteoporosis. Although a normal bone structure will respond to application of mechanical force and weight bearing by forming new bone, a weakened osteoporotic bone may have a tendency to fracture. The study of the skeletal system during weightless conditions will eventually produce preventative measures and form a basis for protecting the crew during long term space flight. The added benefit from these studies will be methods to treat bone loss conditions which occur here on earth.
Doty
St B
SB
Hospital for Special Surgery, New York, NY 10021, USA.
D000469:Alkaline Phosphatase / Q000378:metabolism; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D001842:Bone and Bones / Q000166:cytology / Q000502:physiology*; D002450:Cell Communication / Q000502:physiology; D002453:Cell Cycle / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology; D008854:Microscopy, Electron; D018696:Neuroprotective Agents / Q000378:metabolism; D010006:Osteoblasts / Q000166:cytology* / Q000378:metabolism / Q000648:ultrastructure; D015675:Osteocalcin / Q000378:metabolism; D010012:Osteogenesis / Q000502:physiology*; D010024:Osteoporosis / Q000209:etiology / Q000517:prevention & control; D011347:Procollagen / Q000378:metabolism; D013026:Space Flight; D016212:Transforming Growth Factor beta / Q000378:metabolism; D016474:Weight-Bearing; D014893:Weightlessness / Q000009:adverse effects*
D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D018696:Neuroprotective Agents; D011347:Procollagen; D016212:Transforming Growth Factor beta; D015675:Osteocalcin; D000469:Alkaline Phosphatase