Linkage mapping of the [Pro2]somatostatin-14 gene in zebrafish: evolutionary perspectives.
Radiation hybrid mapping assigned the zebrafish [Pro(2)]somatostatin-14 (also termed somatostatin 2; SS2) gene to linkage group 23 of the zebrafish genome, close to the marker nadl1.2. Comparative genomic analysis revealed conserved syntenies of the SS2 gene locus with part of the human 1p36 region, where the cortistatin gene is located. This observation strongly suggests that the SS2 gene in nonmammalian species and the cortistatin gene in mammals are orthologous.
Tostivint
Hervé
H
European Institute for Peptide Research (IFRMP 23), Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U-413, University of Rouen, Mont-Saint-Aignan, France. herve.tostivint@unv-rouen.fr
Joly
Lucille
L
Lihrmann
Isabelle
I
Conlon
J Michael
JM
Ekker
Marc
M
Vaudry
Hubert
H
D000818:Animals; D002874:Chromosome Mapping / Q000379:methods*; D019143:Evolution, Molecular; D006801:Humans; D013004:Somatostatin / Q000031:analogs & derivatives / Q000235:genetics*; D015027:Zebrafish / Q000235:genetics*; D029961:Zebrafish Proteins / Q000235:genetics*
D029961:Zebrafish Proteins; C077350:somatostatin, Pro(2)-Met(13)-; D013004:Somatostatin