Nitrone derivatives of trolox as neuroprotective agents.
Synthesis of nitrone derivatives of trolox is described. Their biological evaluation was performed in vitro for scavenging different free radicals, inhibiting Fe(2+)-induced lipid peroxidation, and in vivo in a permanent middle cerebral artery occlusion model in mice. New compounds exert pharmacological activities comparable to or better than those of trolox or nitrone-type reference compounds.
Balogh
György T
GT
Gedeon Richter Ltd, Budapest H-1475, 10. PO Box 27, Hungary. gy.balogh@richter.hu
Vukics
Krisztina
K
Könczöl
Arpád
A
Kis-Varga
Agnes
A
Gere
Anikó
A
Fischer
János
J
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001157:Arterial Occlusive Diseases / Q000188:drug therapy / Q000378:metabolism; D002545:Brain Ischemia / Q000188:drug therapy / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002839:Chromans / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology; D017665:Hydroxyl Radical / Q000378:metabolism; D020244:Infarction, Middle Cerebral Artery / Q000188:drug therapy / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D051379:Mice; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D009589:Nitrogen Oxides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000975:Antioxidants; D002839:Chromans; D016166:Free Radical Scavengers; D018696:Neuroprotective Agents; D009589:Nitrogen Oxides; C015388:nitrones; D017665:Hydroxyl Radical; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid