title: Effects of the nitric oxide donor nitroprusside on no-reflow phenomenon during coronary interventions for acute myocardial infarction.
abstract: We tested the effects of the nitric oxide donor nitroprusside as treatment for no reflow in 23 consecutive patients who underwent coronary angioplasty for acute myocardial infarction. No reflow was defined as a decrease of >/=1 Thrombolysis In Myocardial Infarction (TIMI) trial flow grade occurring after successful initial coronary recanalization. Nitroprusside induced a significant improvement in coronary flow, with an increase in TIMI flow grade from 1.5 +/- 0.8 to 2.9 +/- 0.3 (p <0.0001) and in TIMI frame count from 46 +/- 25 to 16 +/- 5 (p <0.0001). There were no significant adverse effects apart from transient hypotension. Intracoronary nitroprusside should be considered as a treatment of no reflow occurring in acute myocardial infarction.
authors.affiliation: Interventional Cardiology Unit, San Filippo Neri Hospital, Rome, Italy. vpasceri@hotmail.com
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Pasceri
authors.forename: Christian
authors.initials: C
authors.lastname: Pristipino
authors.forename: Francesco
authors.initials: F
authors.lastname: Pelliccia
authors.forename: Antonino
authors.initials: A
authors.lastname: Granatelli
authors.forename: Giulio
authors.initials: G
authors.lastname: Speciale
authors.forename: Adriana
authors.initials: A
authors.lastname: Roncella
authors.forename: Bruno
authors.initials: B
authors.lastname: Pironi
authors.forename: Michele
authors.initials: M
authors.lastname: Capasso
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Richichi
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D003326:Coronary Circulation / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology* / Q000628:therapy*; D020030:Nitric Oxide Donors / Q000627:therapeutic use*; D009599:Nitroprusside / Q000627:therapeutic use*; D011446:Prospective Studies
chemical_list: D020030:Nitric Oxide Donors; D009599:Nitroprusside