Stem cells: from epigenetics to microRNAs.
The complexity and cellular diversity of the adult brain arises from the proliferation and differentiation of a small number of stem cells. The intrinsic state of stem cells depends on their spatial and temporal history and affects their responsiveness to extrinsic signals from the microenvironment. Stem cell self-renewal and differentiation along neuronal and glial lineages are defined by the dynamic interplay between transcription, epigenetic control, and posttranscriptional regulators, including microRNAs, whose key role in stem cell biology is just emerging.
Cheng
Li-Chun
LC
Department of Pathology, Columbia University, 630 West 168th Street, New York, New York 10032, USA.
Tavazoie
Masoud
M
Doetsch
Fiona
F
D000818:Animals; D001921:Brain / Q000166:cytology; D002454:Cell Differentiation / Q000235:genetics*; D044127:Epigenesis, Genetic; D006801:Humans; D035683:MicroRNAs; D008959:Models, Neurological; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology*
D035683:MicroRNAs