Lack of significant effect of grapefruit juice on the pharmacokinetics of lansoprazole and its metabolites in subjects with different CYP2C19 genotypes.
Uno
Tsukasa
T
Department of Pharmacy, Hirosaki University Hospital, Hirosaki, Japan.
Yasui-Furukori
Norio
N
Takahata
Takenori
T
Sugawara
Kazunobu
K
Tateishi
Tomonori
T
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000328:Adult; D019540:Area Under Curve; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics* / Q000378:metabolism / Q000494:pharmacology; D001628:Beverages; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D032083:Citrus paradisi; D018592:Cross-Over Studies; D065731:Cytochrome P-450 CYP2C19; D005260:Female; D005838:Genotype; D006207:Half-Life; D006801:Humans; D064747:Lansoprazole; D008297:Male; D006899:Mixed Function Oxygenases / Q000235:genetics* / Q000378:metabolism / Q000494:pharmacology; D009853:Omeprazole / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D014867:Water / Q000008:administration & dosage / Q000737:chemistry
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D010936:Plant Extracts; D014867:Water; D064747:Lansoprazole; D006899:Mixed Function Oxygenases; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19; D009853:Omeprazole; C498264:5-hydroxylansoprazole