Age-dependent effects of the 5-hydroxytryptamine-2a-receptor polymorphism (His452Tyr) on human memory.
A polymorphism (His452Tyr) of the 5-hydroxytryptamine (5-HT)2a receptor is associated with episodic memory in healthy young humans. Because 5-HT2a-receptor density decreases with increasing age, we tested whether the 5-HT2a receptor genotype effect on memory is influenced by age. We investigated the association of the His452Tyr genotype with memory performance in 622 healthy study participants aged from 18 to 90 years. In young to middle-aged participants, age significantly influenced genotype effects on episodic memory: the His452Tyr genotype exerted a significant influence on memory only in young participants. In the group of elderly cognitively healthy participants, the His452Tyr genotype did not affect memory performance. We conclude that age strongly modulates the effect of the 5-HT2a receptor polymorphism at residue 452 on episodic memory.
Papassotiropoulos
Andreas
A
Division of Psychiatry Research, University of Zurich, Lenggstr. 31, 8029 Zurich, Switzerland. papas@bli.unizh.ch
Henke
Katharina
K
Aerni
Amanda
A
Coluccia
Daniel
D
Garcia
Esmeralda
E
Wollmer
Marc A
MA
Huynh
Kim-Dung
KD
Monsch
Andreas U
AU
Stähelin
Hannes B
HB
Hock
Christoph
C
Nitsch
Roger M
RM
de Quervain
Dominique J-F
DJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D005260:Female; D005838:Genotype; D006639:Histidine / Q000235:genetics*; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D013223:Statistics as Topic; D013997:Time Factors; D014443:Tyrosine / Q000235:genetics*
D044402:Receptor, Serotonin, 5-HT2A; D014443:Tyrosine; D006639:Histidine