title: Effect of nifedipine on C-reactive protein levels in the coronary sinus and on coronary blood flow in response to acetylcholine in patients with stable angina pectoris having percutaneous coronary intervention.
abstract: The effects of nifedipine on inflammation and endothelial function in the coronary circulation were studied in patients who had angina pectoris (n = 17). Long-term treatment with nifedipine (nifedipine CR, 20 mg/day for 4 months) decreased levels of C-reactive protein in the coronary sinus (from 0.35 +/- 0.09 mg/dl to 0.07 +/- 0.01 mg/dl, mean +/- SEM, p <0.05) and enhanced acetylcholine-induced increases in coronary blood flow. Thus, nifedipine is effective in decreasing inflammation and incresing endothelial function in the coronary circulation.
authors.affiliation: Department of Internal Medicine, Enshu General Hospital, Hamamatsu.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takase
authors.forename: Takayuki
authors.initials: T
authors.lastname: Toriyama
authors.forename: Masaya
authors.initials: M
authors.lastname: Sugiyama
authors.forename: Ai
authors.initials: A
authors.lastname: Nakazawa
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Hayashi
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Goto
authors.forename: Tomonori
authors.initials: T
authors.lastname: Sugiura
authors.forename: Koshiro
authors.initials: K
authors.lastname: Ikeda
authors.forename: Koichi
authors.initials: K
authors.lastname: Sato
authors.forename: Ryuzo
authors.initials: R
authors.lastname: Ueda
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Dohi
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000368:Aged; D000787:Angina Pectoris / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000201:enzymology / Q000473:pathology; D015906:Angioplasty, Balloon, Coronary; D001783:Blood Flow Velocity; D002097:C-Reactive Protein / Q000378:metabolism*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D003326:Coronary Circulation / Q000187:drug effects; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome; D014463:Ultrasonography; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D014665:Vasodilator Agents; D002097:C-Reactive Protein; D009543:Nifedipine; D000109:Acetylcholine