title: Anxiolytic suppression of repetitive transcranial magnetic stimulation-induced anxiety in the rats.
abstract: Repetitive transcranial magnetic stimulation (rTMS) is effective for treatment of several psychiatric disorders such as depression and anxiety disorder. However, some reports suggest that rTMS induced anxiety in normal volunteers. Consistent with this observation, we have reported that chronic rTMS induces anxiety in normal rats which was suppressed by chronic treatment, but not acute paroxetine treatment. The current study evaluates rTMS as animal model of anxiety by investigating the effect of rTMS on anxiety behaviors and the ability of standard anxiolytics to block expression of these behaviors. We found that 10-day rTMS induced anxiety in normal rats, as evidenced by expression of anxiety behaviors in the elevated plus-maze. This anxiety was suppressed by acute treatment with diazepam, alprazolam, or buspirone suggesting that chronic rTMS treatment provides a good animal model for anxiety.
authors.affiliation: Department of Neuropsychiatry, Oita University Faculty of Medicine, Oita 879-5593, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Isogawa
authors.forename: Minoru
authors.initials: M
authors.lastname: Fujiki
authors.forename: Jotaro
authors.initials: J
authors.lastname: Akiyoshi
authors.forename: Takashi
authors.initials: T
authors.lastname: Tsutsumi
authors.forename: Kensuke
authors.initials: K
authors.lastname: Kodama
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Matsushita
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Hidenori
authors.initials: H
authors.lastname: Kobayashi
mesh_terms: D000161:Acoustic Stimulation; D000525:Alprazolam / Q000627:therapeutic use; D000818:Animals; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy / Q000209:etiology / Q000523:psychology*; D002065:Buspirone / Q000627:therapeutic use; D003975:Diazepam / Q000627:therapeutic use; D004574:Electromagnetic Fields / Q000009:adverse effects*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D014151:Anti-Anxiety Agents; D003975:Diazepam; D002065:Buspirone; D000525:Alprazolam