title: Decrease in glucose-stimulated insulin secretion following exposure to magnetic fields.
abstract: We evaluated the effects of extremely low frequency magnetic field (ELFMF) on glucose-stimulated insulin secretion from HIT-T15 cells and investigated the mechanisms of these effects. We demonstrated that exposure to ELFMF at 5mT decreased glucose-stimulated insulin secretion by preventing the increases in cellular adenosine 5'-triphosphate/adenosine 5'-diphosphate, membrane depolarization, and cytosolic free calcium ion concentration. The glucose-induced upregulation of insulin mRNA expression was also attenuated by exposure to ELFMF, although cell viability was not affected. These findings demonstrate the potential of exposure to ELFMF for clinical use as a novel inhibitory method of insulin secretion.
authors.affiliation: Department of Radiological Technology, School of Health Sciences, Faculty of Medicine, Hirosaki University, Hirosaki, Japan.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Sakurai
authors.forename: Shin
authors.initials: S
authors.lastname: Koyama
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Komatsubara
authors.forename: Wang
authors.initials: W
authors.lastname: Jin
authors.forename: Junji
authors.initials: J
authors.lastname: Miyakoshi
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000528:radiation effects; D006224:Cricetinae; D004307:Dose-Response Relationship, Radiation; D004574:Electromagnetic Fields; D005947:Glucose / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007340:Insulinoma / Q000378:metabolism* / Q000473:pathology*; D011829:Radiation Dosage
chemical_list: D007328:Insulin; D005947:Glucose