Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2.
Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme that catalyzes the conversion of prostaglandin (PG)H2 to PGE2. Proinflammatory stimuli markedly increase levels of mPGES-1 expression both in vivo and in vitro. mPGES-1 knockout studies and animal models of inflammatory arthritis also provide a strong basis for the contribution of mPGES-1 in the increased local production of PGE2 observed in inflammatory arthritis. The focus of this article is to review some recent advances in our understanding of mechanisms specific to the regulation of inducible mPGES-1 in inflammatory arthritis.
Sampey
Annaleise V
AV
University of Michigan, Ann Arbor, MI, USA.
Monrad
Seetha
S
Crofford
Leslie J
LJ
D000818:Animals; D015232:Dinoprostone / Q000096:biosynthesis*; D004790:Enzyme Induction / Q000502:physiology; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000096:biosynthesis*; D008861:Microsomes / Q000201:enzymology*; D000071876:Prostaglandin-E Synthases
D019746:Intramolecular Oxidoreductases; C000605862:PTGES protein, human; D000071876:Prostaglandin-E Synthases; D015232:Dinoprostone