Persistent suppression of phagocytosis after prolonged administration of local anesthetics carbisocaine and heptacaine in mouse leukocytes.
Effects of local anesthetics heptacaine and carbisocaine on mouse peritoneal macrophages after 5 days of peritoneal administration were observed. Both compounds in a daily dose 50 mg/kg caused significant decrease in phagocytic activity and index of phagocytosis (number of ingested particles). No significant effects on phagocytosis were observed when carbisocaine was administrated in a daily dose 5 mg/kg. No significant changes in weight gain and number of peritoneal macrophages were observed in all groups.
Vegh
V
V
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, Odbojarov 10, SK-832 32 Bratislava, Slovakia. vegh@fpharm.uniba.sk
Bukovsky
M
M
D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002219:Carbamates / Q000494:pharmacology*; D005260:Female; D007958:Leukocyte Count; D008099:Liver / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D009929:Organ Size / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects*; D010880:Piperidines / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects
D000779:Anesthetics, Local; D002219:Carbamates; D010880:Piperidines; C013549:heptacaine; C046030:carbizocaine