title: Neurotoxicity of polychlorinated biphenyls (PCBs) by disturbance of thyroid hormone-regulated genes.
abstract: PCBs are known as neurotoxic compounds. Part of this neurotoxicity could be due to an alteration of the expression of TH-regulated genes in brain. To identify such genes, brain protein extracts of hypo- and hyperthyroid as well as PCB-treated embryos were compared by fluorescent 2D-DIGE. In total, we observed 109 differentially expressed proteins, of which 17 differed with both PCB and hypo- or hyperthyroid treatment. It was found that the interaction of PCBs with the expression of TH-regulated genes is congener-specific and that both hyperthyroidism- and hypothyroidism-related effects occur.
authors.affiliation: Laboratory of Comparative Endocrinology, Katholieke Universiteit Leuven, Belgium. simon.roelens@bio.kuleuven.ac.be
authors.forename: S A
authors.initials: SA
authors.lastname: Roelens
authors.forename: V
authors.initials: V
authors.lastname: Beck
authors.forename: G
authors.initials: G
authors.lastname: Aerts
authors.forename: S
authors.initials: S
authors.lastname: Clerens
authors.forename: G
authors.initials: G
authors.lastname: Vanden Bergh
authors.forename: L
authors.initials: L
authors.lastname: Arckens
authors.forename: V M
authors.initials: VM
authors.lastname: Darras
authors.forename: S
authors.initials: S
authors.lastname: van der Geyten
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002642:Chick Embryo; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D013963:Thyroid Hormones / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology
chemical_list: D013963:Thyroid Hormones; D011078:Polychlorinated Biphenyls