title: HPV-associated carcinoma of esophagus in the young: a case report and review of literature.
abstract: Esophageal carcinoma (EC) is rare in the younger age group, with only 15 cases reported in world literature. It is even rarer for an etiological agent to be implicated.A case of a 15-yr-old boy with squamous cell carcinoma of the esophagus is reported. Human papillomavirus (HPV) 16 DNA sequences were detected in the neoplasm and the adjacent mucosa by polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP). The adjacent mucosa also showed virus-induced changes.
authors.affiliation: Department of Pathology, Lilavati Hospital and Research Centre Mumbai, India. pstampi@vsnl.com
authors.forename: Chandralekha
authors.initials: C
authors.lastname: Tampi
authors.forename: Sandhya
authors.initials: S
authors.lastname: Pai
authors.forename: Vatsala M
authors.initials: VM
authors.lastname: Doctor
authors.forename: S
authors.initials: S
authors.lastname: Plumber
authors.forename: P
authors.initials: P
authors.lastname: Jagannath
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D004938:Esophageal Neoplasms / Q000473:pathology* / Q000821:virology*; D006801:Humans; D008297:Male; D027383:Papillomaviridae / Q000235:genetics* / Q000472:pathogenicity*; D030361:Papillomavirus Infections / Q000150:complications*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D004279:DNA, Viral