Mediastinal histoplasmosis: report of the first two Brazilian cases of mediastinal granuloma.
This report documents the first two Brazilian cases of mediastinal granuloma due to histoplasmosis, presenting selected aspects on the diagnosis. Tissue samples revealing histoplasmosis were obtained from each of the patients by mediastinoscopy and thoracotomy. In the second patient, a subcarinal calcified mass eroded into the bronchial tree, leading to secondary bilateral aspiration pneumonitis one week after thoracotomy. Although rare, histoplasmosis should be included in the differential diagnosis of mediastinal granuloma, specially if there are calcifications greater than 10 mm in dimension.
Severo
Luiz Carlos
LC
Departamento de Medicina Interna, FAMED, UFRGS, Porto Alegre, RS, Brazil. severo@santacasa.tche.br
Lemos
Antonio Carlos Moreira
AC
Lacerda
Heloisa Ramos
HR
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D006099:Granuloma / Q000175:diagnosis / Q000382:microbiology*; D006660:Histoplasmosis / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D008477:Mediastinal Diseases / Q000175:diagnosis / Q000382:microbiology*; D008875:Middle Aged; D013908:Thoracotomy
D000935:Antifungal Agents; D017964:Itraconazole