title: Linkage mapping of the [Pro2]somatostatin-14 gene in zebrafish: evolutionary perspectives.
abstract: Radiation hybrid mapping assigned the zebrafish [Pro(2)]somatostatin-14 (also termed somatostatin 2; SS2) gene to linkage group 23 of the zebrafish genome, close to the marker nadl1.2. Comparative genomic analysis revealed conserved syntenies of the SS2 gene locus with part of the human 1p36 region, where the cortistatin gene is located. This observation strongly suggests that the SS2 gene in nonmammalian species and the cortistatin gene in mammals are orthologous.
authors.affiliation: European Institute for Peptide Research (IFRMP 23), Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U-413, University of Rouen, Mont-Saint-Aignan, France. herve.tostivint@unv-rouen.fr
authors.forename: Hervé
authors.initials: H
authors.lastname: Tostivint
authors.forename: Lucille
authors.initials: L
authors.lastname: Joly
authors.forename: Isabelle
authors.initials: I
authors.lastname: Lihrmann
authors.forename: J Michael
authors.initials: JM
authors.lastname: Conlon
authors.forename: Marc
authors.initials: M
authors.lastname: Ekker
authors.forename: Hubert
authors.initials: H
authors.lastname: Vaudry
mesh_terms: D000818:Animals; D002874:Chromosome Mapping / Q000379:methods*; D019143:Evolution, Molecular; D006801:Humans; D013004:Somatostatin / Q000031:analogs & derivatives / Q000235:genetics*; D015027:Zebrafish / Q000235:genetics*; D029961:Zebrafish Proteins / Q000235:genetics*
chemical_list: D029961:Zebrafish Proteins; C077350:somatostatin, Pro(2)-Met(13)-; D013004:Somatostatin