Immunotherapy for pancreatic cancer - science driving clinical progress.
The identification of key signalling pathways involved in immune-system regulation, along with the development of early pancreatic tumours in mouse models have provided new opportunities for pancreatic cancer treatment and prevention. Immunotherapy for pancreatic cancer is one approach that is at a crucial crossroads, as therapeutics that are designed to target pancreatic-cancer-associated antigens and regulatory signalling molecules are entering clinical trials.
Laheru
Dan
D
Department of Medical Oncology, Room G89, Baltimore, Maryland 21231-1000, USA.
Jaffee
Elizabeth M
EM
D000951:Antigens, Neoplasm / Q000276:immunology*; D019496:Cancer Vaccines; D002986:Clinical Trials as Topic; D006801:Humans; D007167:Immunotherapy / Q000379:methods / Q000639:trends*; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000276:immunology* / Q000517:prevention & control; D015398:Signal Transduction
D000951:Antigens, Neoplasm; D019496:Cancer Vaccines