title: Acute left main occlusion during percutaneous coronary intervention associated with heparin induced thrombocytopenia with thrombosis syndrome.
abstract: A 76-year-old male was admitted with Braunwald IIIB unstable angina and treated with intravenous heparin. Coronary angiography 20 days later revealed a severe stenosis in the left circumflex artery. During coronary angioplasty thrombus developed in the circumflex artery, extended in the left main and lead to its occlusion. Normal left coronary artery patency and flow were achieved after intracoronary and intravenous administration of abciximab, and multiple stenting. Platelet-count decrease and an ELISA assay documented the presence of heparin-induced thrombocytopenia with thrombosis syndrome (HITTS). HITTS should be suspected after acute thrombus formation during coronary angioplasty.
authors.affiliation: 1st Department of Cardiology, AHEPA University Hospital, Thessaloniki, Greece. aziakas@med.auth.gr
authors.forename: Antonios
authors.initials: A
authors.lastname: Ziakas
authors.forename: Stavros
authors.initials: S
authors.lastname: Gavrilidis
authors.forename: Pantelis
authors.initials: P
authors.lastname: Makris
authors.forename: George
authors.initials: G
authors.lastname: Louridas
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000188:drug therapy; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use; D017023:Coronary Angiography; D003327:Coronary Disease / Q000209:etiology*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000628:therapy; D006493:Heparin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D013921:Thrombocytopenia / Q000139:chemically induced / Q000150:complications*; D013927:Thrombosis / Q000139:chemically induced / Q000150:complications*
chemical_list: D000925:Anticoagulants; D006493:Heparin