title: Differential role of tumor necrosis factor receptors in TNBS colitis.
abstract: BACKGROUND
  Tumor necrosis factor alpha (TNFalpha) plays a central role in the pathology of T helper 1-mediated colitis such as Crohn's disease; however, the role of its 2 receptors in mediating pathology has not been fully explored.
  
  
  METHODS
  Trinitrobenzene sulfonic acid colitis was used to induce colitis in mice lacking each of the TNF receptors (TNFRs) and in wild-type mice. TNFR1-/- mice lost more weight, became hypothermic, and had increased mortality compared with wild-type C57Bl/6 mice. TNFR2-/- mice, however, lost less weight, had normal temperatures, and had improved survival.
  
  
  RESULTS
  Despite the improved clinical outcomes in TNFR2-/- mice, TNFalpha levels were increased in these mice.
  
  
  CONCLUSIONS
  TNFalpha signaling through TNFR1 is protective in the trinitrobenzene sulfonic acid mouse model of inflammatory bowel disease.
authors.affiliation: Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Washington University, St. Louis, Missouri, USA.
authors.forename: Dawn R
authors.initials: DR
authors.lastname: Ebach
authors.forename: Rodney
authors.initials: R
authors.lastname: Newberry
authors.forename: William F
authors.initials: WF
authors.lastname: Stenson
mesh_terms: D000818:Animals; D003092:Colitis / Q000503:physiopathology* / Q000662:veterinary; D004195:Disease Models, Animal; D007035:Hypothermia / Q000209:etiology; D051379:Mice; D008810:Mice, Inbred C57BL; D009026:Mortality; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology*; D014302:Trinitrobenzenesulfonic Acid / Q000008:administration & dosage / Q000633:toxicity; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*; D015431:Weight Loss
chemical_list: D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D014302:Trinitrobenzenesulfonic Acid