Synthesis, characteristics and biological activity of pentacoordinated spirophosphoranes derived from amino acids.
The reactions of phosphorus trichloride with various amino acids afford the pentacoordinated spirophosphoranes. The reaction procedures were traced by (31)P NMR spectra techniques. A new crystal structure of alanine derivative was characterized, which is a slightly distorted TBP structure. Besides, this kind of spirophosphoranes are potent inhibitors to tyrosinase.
Yu
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Department of Chemistry, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, China.
Liu
Z
Z
Fang
H
H
Zeng
Q L
QL
Zhao
Y F
YF
D000596:Amino Acids / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors; D010753:Phosphoranes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017553:Phosphorus Compounds / Q000737:chemistry*
D000596:Amino Acids; D002712:Chlorides; D004791:Enzyme Inhibitors; D010753:Phosphoranes; D017553:Phosphorus Compounds; D014442:Monophenol Monooxygenase; C043693:phosphorus chloride