title: Impact of noncoronary cusp prolapse in addition to right coronary cusp prolapse in patients with a perimembranous ventricular septal defect.
abstract: BACKGROUND
  Few data are available with regard to the impact of aortic cusp herniation on the evolution of aortic regurgitation (AR) in patients with a perimembranous ventricular septal defect (VSD).
  
  
  METHODS
  One hundred and two patients with a perimembranous ventricular septal defect with right coronary cusp prolapse were divided to two groups depending on the development of aortic regurgitation. The original defect diameter, the right coronary cusp deformity index (RCCD), and the right coronary cusp imbalance index were obtained as we reported previously.
  
  
  RESULTS
  Mild aortic regurgitation was detected in 35 patients, and moderate in three. No aortic regurgitation was observed in 64 patients. A significantly larger number of patients had noncoronary cusp prolapse and the right coronary cusp imbalance index >/=1.30 in the aortic regurgitation group than in the no regurgitation group. Relative risk and odds ratio of noncoronary cusp prolapse and the right coronary cusp imbalance index >/=1.30 for development of aortic regurgitation were 3.69 (95% CI, 0.91-15.03) and 27.90 (95.94-130.85), and 2.23 (0.83-5.98) and 4.70 (1.44-15.27), respectively. Surgical closure was performed in 29 patients. All patients with no noncoronary cusp prolapse underwent simple patch closure of the ventricular septal defect, while five patients with noncoronary cusp prolapse and aortic regurgitation underwent aortic valvuloplasty. Among these, one patient needed aortic valve replacement.
  
  
  CONCLUSIONS
  The additional complication of noncoronary cusp prolapse is a strong risk factor for the development of aortic regurgitation in patients with a perimembranous ventricular septal defect with right coronary cusp prolapse.
authors.affiliation: Department of Pediatrics, Sapporo Medical University, School of Medicine, South-1, West-16, Chuo-ku, Sapporo, Hokkaido, 060-8543, Japan. tomitah@sapmed.ac.jp
authors.forename: Hideshi
authors.initials: H
authors.lastname: Tomita
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Arakaki
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ono
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamada
authors.forename: Toshikatsu
authors.initials: T
authors.lastname: Yagihara
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Echigo
mesh_terms: D000293:Adolescent; D000328:Adult; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging / Q000209:etiology*; D001023:Aortic Valve Prolapse / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D015150:Echocardiography, Doppler; D006345:Heart Septal Defects, Ventricular / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D006801:Humans; D007223:Infant; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D016896:Treatment Outcome