Differential expression of cytokines in the brain and serum during endotoxin tolerance.
Using short- and long-course lipopolysaccharide (LPS) treatment regimens to induce endotoxin tolerance in rats, we compared TNF-alpha, IL-1beta, and IL-6 expression in the brain and serum following a LPS challenge. Serum corticosterone was also examined to evaluate the function of the hypothalamic-pituitary-adrenal (HPA) axis. We found that, during endotoxin tolerance, LPS-induced cytokine expression still occurred in the brain even when cytokines in the periphery were no longer induced, and that this differential cytokine expression may be mediated by corticosterone, a stress hormone and an anti-inflammatory agent.
Chen
Ru
R
Department of Biology, Seton Hall University, 400 South Orange Avenue, South Orange, NJ 07079, USA.
Zhou
Heping
H
Beltran
Jose
J
Malellari
Lorenc
L
Chang
Sulie L
SL
D000818:Animals; D001921:Brain / Q000276:immunology / Q000378:metabolism*; D016207:Cytokines / Q000096:biosynthesis* / Q000097:blood* / Q000235:genetics; D004334:Drug Administration Schedule; D005786:Gene Expression Regulation / Q000276:immunology; D007108:Immune Tolerance / Q000276:immunology*; D008070:Lipopolysaccharides / Q000633:toxicity*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D016207:Cytokines; D008070:Lipopolysaccharides