Protective effects of bio-active ceramic water on alcohol-induced hepatic injury in pigs.
Among many detrimental injuries, alcohol is implicated in hepatitis, fatty liver, hepatic fibrosis, and cirrhosis. The purpose of this study was to evaluate the protective effect of bio-active ceramic water on alcohol-induced hepatic injury in pigs. Twelve male Landrace pigs were divided into 3 groups. Groups 1, 2, and 3 were fed with bio-active ceramic water + normal liquid diet, bio-active ceramic water + liquid diet containing 15% ethanol, and tap water + liquid diet containing 15% ethanol for 12 weeks, respectively. For serological, histopathological, and immunohistochemical analysis, all pigs were sacrificed at week 12. In group 3, serum ALT and AST levels increased, and mild fatty change and moderate necrosis were detected in the liver. Collagen fibers, myofibroblasts, and CYP2E1 were also increased or activated in group 3. In group 2, there were mild hepatic injuries compared to group 3. However, injuries and activations were not observed in the liver in group 1. We suggest that the bio-active ceramic water used in the present study had protective capability against ethanol-induced hepatic injury and that having no toxic effect on the pig liver. The bio-active ceramic water might be useful as a therapeutic drinking water in patients suffering from alcoholic liver diseases.
Lee
Chang-Woo
CW
Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea.
Jeong
Won-Il
WI
Noh
Dong-Hyung
DH
Jeong
Da-Hee
DH
DO
Sun-Hee
SH
Kim
Yoo-Kyeong
YK
Kwon
Oh-Deog
OD
Kim
Tae-Hwan
TH
Jeong
Kyu-Shik
KS
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002516:Ceramics; D002784:Cholesterol / Q000097:blood; D003094:Collagen; D019392:Cytochrome P-450 CYP2E1 / Q000378:metabolism; D007150:Immunohistochemistry; D008108:Liver Diseases, Alcoholic / Q000178:diet therapy* / Q000473:pathology*; D012709:Serum Albumin; D034421:Sus scrofa; D014867:Water / Q000008:administration & dosage*; D018508:Water Purification / Q000379:methods
D012709:Serum Albumin; D014867:Water; D003094:Collagen; D002784:Cholesterol; D019392:Cytochrome P-450 CYP2E1; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase