title: No serological evidence of association between prostate cancer and infection with herpes simplex virus type 2 or human herpesvirus type 8: a nested case-control study.
abstract: Sexual history has consistently been found to be a risk factor for the development of prostate cancer. An association between prostate cancer and herpes simplex virus type 2 (HSV-2) or Kaposi sarcoma-associated herpesvirus/human herpesvirus type 8 (HHV-8) infections has also been reported. Linkage of data on a cohort of 20,243 healthy Finnish men identified 165 cases of prostate cancer that were diagnosed up to 24 years after donation of a serum sample. Two control subjects were matched by age, sex, and municipality of residence to each case patient. Serum levels of immunoglobulin G against HSV-2 and HHV-8 were determined. Neither HSV-2 infection (odds ratio [OR], 0.93 [95% confidence interval {CI}, 0.44-1.96]) nor HHV-8 infection (OR, 0.74 [95% CI, 0.19-2.88]) was associated with prostate cancer.
authors.affiliation: Department of Medical Microbiology, Lund University, University Hospital, Malmo, Sweden.
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Korodi
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Wang
authors.forename: Rosamaria
authors.initials: R
authors.lastname: Tedeschi
authors.forename: Paul
authors.initials: P
authors.lastname: Knekt
authors.forename: Joakim
authors.initials: J
authors.lastname: Dillner
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D016022:Case-Control Studies; D006558:Herpes Genitalis / Q000150:complications*; D006566:Herpesviridae Infections / Q000150:complications*; D019288:Herpesvirus 8, Human / Q000302:isolation & purification; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000821:virology*
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G