[Estimation of potential mutagenic activity of 24-epibrassinolide].
Genotoxic effect of synthetic phytohormone analogue of steroid origin epibrassinolide was studied in in vitro- and in vivo-tests. Epibrassinolide did not display mutagenic properties in Ames' test (S. typhimurium, TA100) and DNA damaging activity test (DNA of phage lambda). The rise in the level of polichromatophilous erythrocytes with micronuclei was observed in the micronuclear test at intraperitoneal epibrassinolide injection at the dose of 500 mg/kg that seems to be associated with disturbance of cell membrane permeability.
Voĭtovich
A M
AM
Nadzharian
L A
LA
Kotelenets
A I
AI
Afonin
V Iu
VIu
Davydovskiĭ
A G
AG
Ushkov
A A
AA
Gavrilenko
N V
NV
D000818:Animals; D060406:Brassinosteroids; D002777:Cholestanols / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects; D051379:Mice; D008808:Mice, Inbred CBA; D048629:Micronuclei, Chromosome-Defective; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D009153:Mutagens / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D013260:Steroids, Heterocyclic / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity*
D060406:Brassinosteroids; D002777:Cholestanols; D009153:Mutagens; D013260:Steroids, Heterocyclic; C023623:brassinolide