title: Developmental expression of NPY/PYY receptors zYb and zYc in zebrafish.
abstract: This study describes the developmental expression of zYb and zYc receptors in zebrafish. RT-PCR demonstrated that both mRNAs are present from 24-hour postfertilization (hpf) and that their expression increased during larval development. Whole-mount in situ hybridization showed zYb mRNA expression in the epithalamus (24 hpf), telencephalon, hypothalamus, rhombencephalon (24-96 hpf), mesencephalon (48-96 hpf), hatching gland, and otic vesicle (48-64 hpf). zYc mRNA is expressed in the epithalamus (24 and 96 hpf), telencephalon (48-96 hpf), spinal cord, notochord (64 hpf), and hatching gland (96 hpf). These results show that zYb and zYc receptors are expressed during ontogeny, suggesting a role for neuropeptide Y (NPY) and/or peptide YY (PYY) in organogenesis.
authors.affiliation: Department of Experimental Biology, University of Genova, Italy. pmod@unige.it
authors.forename: Maura
authors.initials: M
authors.lastname: Mathieu
authors.forename: Sonya
authors.initials: S
authors.lastname: Trombino
authors.forename: Francesco
authors.initials: F
authors.lastname: Argenton
authors.forename: Dan
authors.initials: D
authors.lastname: Larhammar
authors.forename: Mauro
authors.initials: M
authors.lastname: Vallarino
mesh_terms: D000818:Animals; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D009478:Neuropeptide Y / Q000096:biosynthesis* / Q000235:genetics; D011964:Receptors, Gastrointestinal Hormone / Q000096:biosynthesis* / Q000235:genetics; D015027:Zebrafish / Q000196:embryology / Q000235:genetics / Q000378:metabolism*
chemical_list: D009478:Neuropeptide Y; D011964:Receptors, Gastrointestinal Hormone; C082172:peptide YY receptor