title: The BNP assay does not identify mild left ventricular diastolic dysfunction in asymptomatic diabetic patients.
abstract: OBJECTIVE
  We examined the usefulness of BNP for screening for left ventricular (LV) diastolic dysfunction in a sample of type 2 diabetic patients, without structural heart disorder, who have never presented symptoms or signs of heart failure (HF).
  
  
  RESULTS
  Seventy-six consecutive patients admitted to the Outpatient Diabetes Clinic were studied. Blood samples were analyzed using the Triage BNP fluorescence immunoassay (Biosite Diagnostics, La Jolla, CA, USA). Echocardiography examinations were performed, with no knowledge of the BNP value. A total of 39 patients out of 76 (51%) were diagnosed with LV diastolic dysfunction and 23 (30%) with LV hypertrophy. Of the patients with LV diastolic dysfunction, impaired relaxation and pseudonormal pattern accounted for 97 and 3% of the cases, respectively. BNP levels among subjects with LV diastolic dysfunction (26+/-22 pg/ml, n=39) were not significantly different from patients with normal LV function (24+/-23 pg/ml, n=37 pg/ml; Mann-Whitney U-test, Z=-0.4, n.s.).
  
  
  CONCLUSIONS
  Our data confirm alarmingly high prevalence of LV diastolic dysfunction in asymptomatic individuals with diabetes. Identification of patients with preclinical diabetic cardiomyopathy should be a research and clinical priority. BNP levels cannot be used to detect mild LV diastolic dysfunction in this subset of patients, which requires Doppler echocardiography to be detected.
authors.affiliation: Heart Failure Centre, Cardiology Unit, Ospedale Civile, Via Sauro 26, San Donà di Piave, I-30027 VE, Italy. robertovalle@libero.it
authors.forename: R
authors.initials: R
authors.lastname: Valle
authors.forename: E
authors.initials: E
authors.lastname: Bagolin
authors.forename: C
authors.initials: C
authors.lastname: Canali
authors.forename: P
authors.initials: P
authors.lastname: Giovinazzo
authors.forename: S
authors.initials: S
authors.lastname: Barro
authors.forename: N
authors.initials: N
authors.lastname: Aspromonte
authors.forename: E
authors.initials: E
authors.lastname: Carbonieri
authors.forename: L
authors.initials: L
authors.lastname: Milani
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003971:Diastole; D015150:Echocardiography, Doppler; D005260:Female; D016231:Fluorescence Polarization Immunoassay; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology*
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain; D003404:Creatinine