[Discussion on design and quality control of clinical trials of traditional Chinese medicine on the basis of Fuhuang Tablets clinical study].
OBJECTIVE
To assess the efficacy of Fuhuang Tablets in treating internal hemorrhoid hemorrhage and discussing the design and quality control of clinical trials of traditional Chinese medicine.


METHODS
According to two-center, randomized, blinded and controlled study, 144 patients with internal hemorrhoids were divided into 2 groups. Seventy-two patients were treated with Fuhuang Tablets (4 tablets t.i.d. per os) and the other 72 patients were treated with Zhining Tablets (4 tablets t.i.d. per os). Symptoms and signs of the patients were recorded and evaluated at the third and seventh day of treatment respectively.


RESULTS
At the third day of treatment, the overall response rates of Fuhuang Tablets-treated group and Zhining Tablets-treated group were 58.57% and 27.78% respectively, with statistic difference between the two groups (P<0.05). At the seventh day of treatment, the overall response rates of Fuhuang Tablets-treated group and Zhining Tablets-treated group were 91.43% and 81.94% respectively, with no statistic difference between the two groups. The laboratory test results and life signs of the 144 patients were normal before and after the treatment.


CONCLUSIONS
Fuhuang Tablets are effective and safe in treating internal hemorrhoid hemorrhage.
Lu
Jin-Gen
JG
Shanghai Municipal Clinical Medicine Center for Chinese Traditional Surgery, Shanghai 200032, China. lujingen@longhua.net
Pan
Yi-Bin
YB
Cao
Yong-Qing
YQ
Yang
Wei
W
Zhang
Xin-Lin
XL
D000293:Adolescent; D000328:Adult; D000368:Aged; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006484:Hemorrhoids / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D008517:Phytotherapy; D011786:Quality Control; D012107:Research Design; D016037:Single-Blind Method; D013607:Tablets; D016896:Treatment Outcome
D004365:Drugs, Chinese Herbal; D013607:Tablets