title: Erythropoietin-resistant anaemia in a predialysis patient with Klinefelter syndrome.
abstract: A diabetic predialysis patient who had significantly reduced sensitivity to erythropoietin therapy was admitted to Tsukuba University Hospital. Many factors that might have been the cause of the erythropoietin resistance were examined, and a diagnosis of refractory anaemia was made based on a bone marrow aspiration biopsy. A cytogenetic abnormality (47, XXY) was also detected in the bone marrow biopsy specimen, and hence the patient was also diagnosed with Klinefelter syndrome. It was suspected that the sex chromosome abnormality influenced glucose intolerance, renal insufficiency, and erythropoietin resistance due to myelodysplastic changes in the bone marrow.
authors.affiliation: Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba City, Ibaraki, Japan. y-shimz@md.tsukuba.ac.jp
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Kazumi
authors.initials: K
authors.lastname: Suzukawa
authors.forename: Yuko
authors.initials: Y
authors.lastname: Hirano
authors.forename: Masanori
authors.initials: M
authors.lastname: Seki
authors.forename: Kouichi
authors.initials: K
authors.lastname: Hirayama
authors.forename: Keigyo
authors.initials: K
authors.lastname: Yoh
authors.forename: Aki
authors.initials: A
authors.lastname: Hirayama
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Yamagata
authors.forename: Sohji
authors.initials: S
authors.lastname: Nagase
authors.forename: Toshiro
authors.initials: T
authors.lastname: Nagasawa
authors.forename: Akio
authors.initials: A
authors.lastname: Koyama
mesh_terms: D000740:Anemia / Q000188:drug therapy* / Q000209:etiology; D004351:Drug Resistance; D004921:Erythropoietin / Q000008:administration & dosage*; D006801:Humans; D007621:Karyotyping; D007713:Klinefelter Syndrome / Q000150:complications* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D051437:Renal Insufficiency / Q000150:complications*
chemical_list: D004921:Erythropoietin