title: diastereoselective intramolecular Alder-Ene reaction on chiral perhydro-1,3-benzoxazines. a rapid entry to enantiopure cis-3,4-disubstituted pyrrolidines.
abstract: Chiral 3-acryloyl-2-vinyl-substituted 1,3-perhydrobenzoxazines derived from (-)-8-aminomenthol participate in an ene reaction leading to 3,4-disubstituted pyrrolidinone derivates with excellent diastereoselectivity. The cycloadducts were transformed into enantiopure 3,4-disubstituted pyrrolidines after elimination of the chiral adjuvant.
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Valladolid, Dr. Mergelina s/n, 47011 Valladolid, Spain. pedrosa@qo.uva.es
authors.forename: Rafael
authors.initials: R
authors.lastname: Pedrosa
authors.forename: Celia
authors.initials: C
authors.lastname: Andrés
authors.forename: Laura
authors.initials: L
authors.lastname: Martín
authors.forename: Javier
authors.initials: J
authors.lastname: Nieto
authors.forename: Carlos
authors.initials: C
authors.lastname: Rosón