Synthesis of nucleoside alpha-thiotriphosphates via an oxathiaphospholane approach.
[reaction: see text]. Nucleoside 5'-O-(alpha-thiotriphosphates) were obtained in reactions of the appropriate nucleoside 5'-O-(2-thio-1,3,2-oxathiaphospholanes) with pyrophosphate in the presence of DBU. The presented method allows also for preparation of alpha-seleno congeners and corresponding alpha-modified diphosphates.
Misiura
Konrad
K
Department of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Łódź, Poland.
Szymanowicz
Daria
D
Stec
Wojciech J
WJ
D007202:Indicators and Reagents; D015394:Molecular Structure; D009711:Nucleotides / Q000737:chemistry*; D012266:Ribose / Q000031:analogs & derivatives* / Q000737:chemistry; D013237:Stereoisomerism; D013873:Thionucleotides / Q000138:chemical synthesis* / Q000737:chemistry
D007202:Indicators and Reagents; D009711:Nucleotides; D013873:Thionucleotides; C434797:oxathiaphospholane; D012266:Ribose