Transgenic plants for the production of veterinary vaccines.
The expression of antigens in transgenic plants has been increasingly used in the development of experimental vaccines, particularly oriented to the development of edible vaccines. Hence, this technology becomes highly suitable to express immunogenic proteins from pathogens. Foot and mouth disease virus, bovine rotavirus and bovine viral diarrhoea virus are considered to be the most important causative agents of economic loss of cattle production in Argentina, and they are thus optimal candidates for alternative means of immunization. Here, we present a review of our results corresponding to the expression of immunogenic proteins from these three viruses in alfalfa transgenic plants, and we discuss the possibility of using them for the development of plant-based vaccines.
Dus Santos
María José
MJ
Veterinary and Agronomy Research Center, INTA-Castelar, Buenos Aires, Argentina.
Wigdorovitz
Andrés
A
D000818:Animals; D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology; D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D001908:Diarrhea Viruses, Bovine Viral / Q000235:genetics / Q000276:immunology; D029544:Foot-and-Mouth Disease Virus / Q000235:genetics / Q000276:immunology; D000455:Medicago sativa / Q000235:genetics / Q000378:metabolism; D030821:Plants, Genetically Modified / Q000235:genetics / Q000378:metabolism*; D012401:Rotavirus / Q000235:genetics / Q000276:immunology; D011198:Solanum tuberosum / Q000235:genetics / Q000378:metabolism; D022462:Vaccines, Edible / Q000008:administration & dosage / Q000096:biosynthesis* / Q000235:genetics; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000096:biosynthesis / Q000235:genetics; D014730:Veterinary Medicine / Q000379:methods; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000096:biosynthesis* / Q000235:genetics
D000956:Antigens, Viral; D022462:Vaccines, Edible; D014614:Vaccines, Synthetic; D014764:Viral Proteins; D014765:Viral Vaccines