Calculating colon transit time with radionuclide-filled capsules in constipated patients: a new method for colon transit study.
BACKGROUND
Colon motility disorders require reliable methods for calculating segmental colonic transit time. This study evaluated bowel transit time by means of a safe, easy, cheap, non-digestive, and non-disintegrating radionuclide-filled capsule that provided accurate and clear images.


METHODS
Radionuclide-filled mini-containers (MCs) were prepared from infusion sets by an apparatus used for sealing blood bags or plasmapheresis sets. In vitro stability studies were performed by immersing 5% methylene blue dye-filled MCs in buffers of variable pH and enzymes simulating the conditions in the stomach and the small bowel. Colon transit scintigraphy was performed with MCs filled with iodine 131 (n = 5) and thallium 201 (n = 8) that were placed in a commercially available capsule.


RESULTS
By in vitro acid, base, and intestinal enzyme resistance tests, no methylene blue leakage was determined visually and by spectrophotometric analysis. Accurate and clear images were obtained for colon transit study in constipated patients. After excretion of MCs in the feces, abdominal, myocardial, thyroid, and urinary bladder region counts were found to show the same activity as the background. Radionuclide leakage from MCs was not determined in vivo by gamma camera.


CONCLUSIONS
This is a suitable, safe, easy, and cheap method to provide accurate and clear images for colon transit study in constipated patients.
Kekilli
E
E
Department of Nuclear Medicine, Turgut Ozal Medical Center, Inonu University, Malatya 44069, Turkey. ekekilli@inonu.edu.tr
Yagmur
C
C
Isik
B
B
Aydin
O M
OM
D000328:Adult; D002214:Capsules; D003106:Colon / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003248:Constipation / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D005772:Gastrointestinal Transit / Q000502:physiology*; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013794:Thallium Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics
D002214:Capsules; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D013794:Thallium Radioisotopes