Effect of cytogenin, a novel immunomodulator, on streptozotocin-induced diabetes in mice.
The anti-diabetic effect of cytogenin was examined using streptozotocin-induced diabetes in mice. Cytogenin suppressed not only the increase of plasma glucose level but also the body weight reduction in diabetic mice. Histological examination of the pancreas taken from diabetic mice given cytogenin showed that cytogenin decreased the number of macrophages infiltrated into islet of pancreas. Further, cytogenin suppressed the nitric oxide generation by macrophages treated with lipopolysaccharide through decreasing of inducible nitric oxide synthase expression. Cytogenin suppressed interleukin-6 expression by macrophage treated with LPS, suggesting that the anti-diabetic activity of cytogenin might be partly attributed to the suppressive activity against nitric oxide generation.
Kumagai
Hiroyuki
H
Numazu Bio-Medical Research Institute, Microbial Chemistry Research Foundation, 18-24 Miyamoto, Numazu, Shizuoka 410-0301, Japan.
Wakazono
Kuniko
K
Agata
Naoki
N
Isshiki
Kunio
K
Ishizuka
Masaaki
M
Ikeda
Daishiro
D
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003374:Coumarins / Q000627:therapeutic use*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007155:Immunologic Factors / Q000627:therapeutic use*; D066298:In Vitro Techniques; D015850:Interleukin-6 / Q000096:biosynthesis; D007515:Islets of Langerhans / Q000187:drug effects / Q000473:pathology; D049934:Isocoumarins; D008264:Macrophages / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis
D001786:Blood Glucose; D003374:Coumarins; D007004:Hypoglycemic Agents; D007155:Immunologic Factors; D015850:Interleukin-6; D049934:Isocoumarins; C066806:cytogenin; D009569:Nitric Oxide