title: ACE inhibitor captopril reduces ecdysteroids and oviposition in moths.
abstract: By using the selective ACE inhibitor captopril, we studied the effect of the angiotensin converting enzyme (ACE) on larval growth, metamorphosis, and reproduction in a lepidopteran species, the cotton leafworm, Spodoptera littoralis. Captopril was detrimental to adult formation and oviposition, and in female moths it elicited decreasing ecdysteroid levels, but increasing trypsin activities. Our results suggest that captopril downregulates oviposition by two independent pathways. Apparently, oviposition is influenced by a complex interaction of ACE, trypsin activity, and ecdysteroid levels.
authors.affiliation: Laboratory of Agrozoology, Department of Crop Protection, Faculty of Bioscience Engineering, Ghent University, Belgium. lieselot.vercruysse@ugent.be
authors.forename: L
authors.initials: L
authors.lastname: Vercruysse
authors.forename: D
authors.initials: D
authors.lastname: Gelman
authors.forename: S
authors.initials: S
authors.lastname: van de Velde
authors.forename: E
authors.initials: E
authors.lastname: Raes
authors.forename: B
authors.initials: B
authors.lastname: Hooghe
authors.forename: V
authors.initials: V
authors.lastname: Vermeirssen
authors.forename: J
authors.initials: J
authors.lastname: van Camp
authors.forename: G
authors.initials: G
authors.lastname: Smagghe
mesh_terms: D000367:Age Factors; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D002216:Captopril / Q000494:pharmacology*; D026461:Ecdysteroids / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005260:Female; D008297:Male; D010058:Oviposition / Q000187:drug effects* / Q000502:physiology; D018411:Spodoptera / Q000033:anatomy & histology / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D026461:Ecdysteroids; D002216:Captopril