Effects of chronic lead exposure on 1H MRS of hippocampus and frontal lobes in children.
The authors performed IQ testing and magnetic resonance spectroscopy on six lead-exposed and six control children. Levels of N-acetyl aspartate (neuronal density and mitochondrial metabolism), creatine + phosphocreatine (phosphate metabolism), and choline (membrane turnover) were decreased in four brain regions (left and right frontal, left and right hippocampus) in lead-exposed children vs controls. The reductions were right frontal > left frontal > hippocampus but were the same bilaterally in the hippocampus.
Meng
X-M
XM
School of Life Science, University of Science and Technology of China, Hefei, Anhui, P. R. China.
Zhu
D-M
DM
Ruan
D-Y
DY
She
J-Q
JQ
Luo
L
L
D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000097:blood; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D002648:Child; D002794:Choline / Q000097:blood; D002908:Chronic Disease; D003072:Cognition Disorders / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology; D003401:Creatine / Q000097:blood; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D005625:Frontal Lobe / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D007839:Functional Laterality / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007854:Lead / Q000009:adverse effects* / Q000097:blood; D020264:Lead Poisoning, Nervous System, Childhood / Q000097:blood* / Q000175:diagnosis* / Q000503:physiopathology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism
D010743:Phospholipids; D007854:Lead; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline