Synthesis of the putative structure of 7-deoxycylindrospermopsin: C7 oxygenation is not required for the inhibition of protein synthesis.
Looper
Ryan E
RE
Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.
Runnegar
Maria T C
MT
Williams
Robert M
RM
D000470:Alkaloids; D000818:Animals; D001427:Bacterial Toxins; D001681:Biological Assay; D018360:Crystallography, X-Ray; D000087522:Cyanobacteria Toxins; D004305:Dose-Response Relationship, Drug; D005978:Glutathione / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D008958:Models, Molecular; D008968:Molecular Conformation; D010084:Oxidation-Reduction; D011500:Protein Synthesis Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014498:Uracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
C513693:5-chlorocylindrospermopsin; C513692:7-deoxycylindrospermopsin; D000470:Alkaloids; D001427:Bacterial Toxins; D000087522:Cyanobacteria Toxins; D011500:Protein Synthesis Inhibitors; C089595:cylindrospermopsin; D014498:Uracil; D005978:Glutathione