[Cytoapheresis for IBD].
Ulcerative colitis (UC) is associated with chronic relapsing inflammation of the colon. Cytoapheresis is a therapeutic strategy of extracorporeal immunomodulation that has been used in several immunological disorders. In Japan, several open trials of cytoapheresis for UC patients accumulated encouraging results in bringing steroid-resistant patients into remission. In this paper, three types of cytoapheresis [leukocytapheresis (LCAP), granulocytapheresis (GCAP), and centrifugal leukocyte apheresis] are reviewed.
Andoh
Akira
A
Department of Internal Medicine, Shiga University of Medical Science.
Fujiyama
Yoshihide
Y
D015496:CD4-Positive T-Lymphocytes; D003093:Colitis, Ulcerative / Q000276:immunology / Q000628:therapy*; D016238:Cytapheresis / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D007375:Interleukin-1 / Q000276:immunology; D015850:Interleukin-6 / Q000096:biosynthesis; D016209:Interleukin-8 / Q000096:biosynthesis; D007958:Leukocyte Count; D009000:Monocytes; D010976:Platelet Count
D007375:Interleukin-1; D015850:Interleukin-6; D016209:Interleukin-8