Preparation of alpha-cyclodextrin-terminated polyrotaxane consisting of beta-cyclodextrins and pluronic as a building block of a biodegradable network.
A beta-CD-based biodegradable polyrotaxane was prepared by capping both terminals of polypseudorotaxane consisting of hydrazide-terminated PEG-block-PPG-block-PEG (Pluronic P-105) and beta-CD-succinates with mono-aldehyde alpha-CDs. By decreasing pH, the fluorescent intensity of TNS was increased with time, indicating cleavage of the terminal hydrazone bonds followed by beta-CD-succinate release. The terminal alpha-CD moieties of the polyrotaxane are useful for self-assembled formation with some guest molecules. [Diagram: see text]
Ooya
Tooru
T
School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, Ishikawa 923-1292, Japan.
Ito
Akihiro
A
Yui
Nobuhiko
N
D001673:Biodegradation, Environmental; D006863:Hydrogen-Ion Concentration; D009904:Optical Rotation; D020442:Poloxamer / Q000737:chemistry*; D011092:Polyethylene Glycols; D011108:Polymers; D011409:Propylene Glycols; D043862:Rotaxanes / Q000138:chemical synthesis* / Q000737:chemistry; D047391:alpha-Cyclodextrins / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
D011108:Polymers; D011409:Propylene Glycols; D043862:Rotaxanes; D047391:alpha-Cyclodextrins; D047392:beta-Cyclodextrins; D020442:Poloxamer; C012504:polypropylene glycol; D011092:Polyethylene Glycols; C031215:betadex; C032613:alpha-cyclodextrin