title: Polyethylene wear particle generation in vivo in an alumina medial pivot total knee prosthesis.
abstract: Polyethylene wear particle generation is one of the most important factors affecting mid- to long-term results of total knee arthroplasties. It has been reported that the medial pivot total knee prosthesis (MP) design and alumina ceramic femoral component reduce polyethylene wear. The aim of this study is to evaluate in vivo polyethylene wear particle generation in the newly introduced alumina MP, in comparison with a metal MP. Synovial fluid was obtained from 11 knees with alumina MP and 15 knees with metal MP at nine months after the operation. Polyethylene particles were isolated, and examined using scanning electron microscope and image analyzer. Total number of particles in each knee was 7.10+/-2.86x10(6) in alumina (mean+/-standard error), and 5.70+/-2.82x10(7) in metal MP (p=0.048). Particle size (equivalent circle diameter) was 0.78+/-0.04 microm in alumina, and 0.66+/-0.06 microm in metal MP (p=0.120). Particle shape (aspect ratio) was 1.52+/-0.05 in alumina, and 1.88+/-0.11 in metal MP (p=0.014). Apart from the femoral component, the material and manufacturing method of polyethylene insert differed between the two groups, although the sterilization method was the same. Alumina MP generated fewer and rounder polyethylene wear particles than metal MP in early clinical stage, and could potentially reduce prevalence of osteolysis and aseptic loosening.
authors.affiliation: Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi Abeno-ku Osaka 545-8585, Japan.
authors.forename: Yukihide
authors.initials: Y
authors.lastname: Minoda
authors.forename: Akio
authors.initials: A
authors.lastname: Kobayashi
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Iwaki
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Miyaguchi
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kadoya
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Ohashi
authors.forename: Kunio
authors.initials: K
authors.lastname: Takaoka
mesh_terms: D000368:Aged; D000535:Aluminum / Q000737:chemistry; D000537:Aluminum Oxide; D019645:Arthroplasty, Replacement, Knee; D001672:Biocompatible Materials; D002516:Ceramics / Q000737:chemistry; D005260:Female; D006801:Humans; D007720:Knee Prosthesis; D008297:Male; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D010003:Osteoarthritis / Q000378:metabolism; D020959:Polyethylene / Q000737:chemistry*; D011095:Polyethylenes / Q000737:chemistry; D011474:Prosthesis Design; D011475:Prosthesis Failure; D013582:Synovial Fluid / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D011095:Polyethylenes; D020959:Polyethylene; D000535:Aluminum; D000537:Aluminum Oxide