title: [Wnt signaling and bone metabolism].
abstract: The Wnt family of secreted signaling molecules is essential in embryo development and tumor formation. In addition to the Frizzled family of serpentine receptors, LRP5, a member of the LDL receptor family, was recently shown to function as Wnt receptor. The finding of unique mutations in the human LRP5 gene as a modulator of bone mass establishes the importance of this novel and unexpected role of Wnt/LRP5 signaling in bone development and bone metabolism.
authors.affiliation: Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Asaba
authors.forename: Juro
authors.initials: J
authors.lastname: Sakai
mesh_terms: D001842:Bone and Bones / Q000378:metabolism*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology*; D026502:LDL-Receptor Related Proteins / Q000502:physiology*; D060492:Low Density Lipoprotein Receptor-Related Protein-5; D015398:Signal Transduction / Q000502:physiology; D051153:Wnt Proteins
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D026502:LDL-Receptor Related Proteins; C555482:LRP5 protein, human; D060492:Low Density Lipoprotein Receptor-Related Protein-5; D051153:Wnt Proteins