title: [Role of chronic prostatic infiltrate from specimens of prostate biopsy in total and free PSA determination].
abstract: OBJECTIVE
  To analyze the influence in total serum PSA (PSA(t)) and free PSA (PSA(1)) of chronic inflammatory patterns from prostate biopsy specimens of non-symptomatic patients.
  
  
  METHODS
  518 non-symptomatic patients underwent ultrasonography and prostatic biopsy for PSA(t) > 4 ng/mL and/or DRE suspicious of malignancy. Those with a negative biopsy were divided into two subgroups: patients with benign prostatic lesions (LBP) and patients with chronic inflammatory signs (SIC).
  
  
  RESULTS
  456 patients (88.03%) were biopsied for elevated PSA(t) or/and DRE suspicious of malignancy in 62 patients (11.97%). Mean volume in patients with LBP was 54cc, while 51cc was the mean volume in patients with histological pattern of chronic inflammatory infiltrate. Mean PSA(t) in patients with LBP was 9.43 (IC 95% +/- 7.8) and 8.8 (IC 95% +/- 5.73) in SIC's group patients.
  
  
  CONCLUSIONS
  The presence of SIC has no significant influence in the eventual value of PSA(1) y PSA(t) in a selected population. As a result of that finding data from serum PSA can be reliably evaluated even in the presence of SIC in biopsy specimens.
authors.affiliation: Servicio de Urología, Hospital Universitario La Fe, Valencia.
authors.forename: L
authors.initials: L
authors.lastname: Gómez Pérez
authors.forename: A
authors.initials: A
authors.lastname: Budía Alba
authors.forename: A
authors.initials: A
authors.lastname: Benedicto Redón
authors.forename: F J
authors.initials: FJ
authors.lastname: Delgado Oliva
authors.forename: J L
authors.initials: JL
authors.lastname: Palmero Martí
authors.forename: J F
authors.initials: JF
authors.lastname: Jiménez Cruz
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D002908:Chronic Disease; D006801:Humans; D008297:Male; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood*; D011472:Prostatitis / Q000097:blood / Q000473:pathology*; D012189:Retrospective Studies
chemical_list: D017430:Prostate-Specific Antigen