title: [Antiphospholipid antibodies and pregnancy].
abstract: The presence of antiphospholipid antibodies is associated with a clinical syndrome characterised by thrombocytopenia, arterial and venous thromboses and recurrent fetal loss. Among theses antibodies currently detectable in laboratory are the lupus anticoagulant and anticardiolipin antibody. The antigens for theses antibodies are phospholipid-binding-proteins (prothrombin and beta 2 glycoprotein I). The exact mechanism of action of antiphospholipid antibodies remains controversal. The pathogenis of pregnancy loss seems related to the increased incidence of placental infraction. In spite of the improvement in our knowledge on the pathogenic mechanisms of the antiphospholipid syndrome, the standard therapy is still based on anti-platelet or anticoagulant drugs, both for vascular and obstetrical problems. Larger prospective clinical studies are needed to validate therapeutic implications.
authors.affiliation: Service de Gynécologie obstétrique III. Unité de PMA. Port Royal (CHU Cochin). Paris.
authors.forename: Moez
authors.initials: M
authors.lastname: Kdous
authors.forename: Rim
authors.initials: R
authors.lastname: Hachicha
authors.forename: Raoul
authors.initials: R
authors.lastname: Lombroso
authors.forename: Gustavo
authors.initials: G
authors.lastname: Gallardo
mesh_terms: D000026:Abortion, Habitual / Q000209:etiology*; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D005260:Female; D006801:Humans; D011247:Pregnancy
chemical_list: D017152:Antibodies, Antiphospholipid