The influence of a cellular size distribution on NMR diffusion measurements.
In the magnetic resonance community, the usefulness of diffusion-weighted imaging is undisputed. However, the correct interpretation of multicomponent diffusion is not widely agreed upon, and progress in this direction is impeded by several confounding experimental results. It is thus of great importance to resolve possible interfering factors. The objective of the present study is to examine the influence of a cellular size distribution. Using the Kärger equations, numerical calculations show that even substantial cellular size variations induce only small changes in the estimated compartmental diffusion constants and volume fractions.
Jespersen
Sune Nørhøj
SN
MR-Research Center, Aarhus University Hospital, Brendstrupgaardsvej, 8200 Aarhus N, Denmark. sune@mr.au.dk
Pedersen
Michael
M
Stødkilde-Jørgensen
Hans
H
D000818:Animals; D002452:Cell Count; D002468:Cell Physiological Phenomena; D048429:Cell Size; D003198:Computer Simulation; D004058:Diffusion; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008954:Models, Biological; D014867:Water / Q000378:metabolism*
D014867:Water