Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels.
Elevated plasma levels of C-reactive protein (CRP), an inflammation-sensitive marker, have emerged as an important predictor of future cardiovascular disease and metabolic abnormalities in apparently healthy men and women. Here, we performed a systematic survey of common nucleotide variation across the genomic region encompassing the CRP gene locus. Of the common single-nucleotide polymorphisms (SNPs) identified, several in the CRP promoter region are strongly associated with CRP levels in a large cohort study of cardiovascular risk in European American and African American young adults. We also demonstrate the functional importance of these SNPs in vitro.
Carlson
Christopher S
CS
Department of Genome Sciences, University of Washington, Seattle, WA, USA. csc47@u.washington.edu
Aldred
Shelley Force
SF
Lee
Philip K
PK
Tracy
Russell P
RP
Schwartz
Stephen M
SM
Rieder
Mark
M
Liu
Kiang
K
Williams
O Dale
OD
Iribarren
Carlos
C
Lewis
E Cora
EC
Fornage
Myriam
M
Boerwinkle
Eric
E
Gross
Myron
M
Jaquish
Cashell
C
Nickerson
Deborah A
DA
Myers
Richard M
RM
Siscovick
David S
DS
Reiner
Alexander P
AP
D000293:Adolescent; D001483:Base Sequence; D002097:C-Reactive Protein / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic
D002097:C-Reactive Protein