Synthesis and structure-activity relationships of 2-alkylidenethiazolidine-4,5-diones as antibiotic agents.
2-Alkylidenethiazolidine-4,5-diones were prepared by novel one-pot cyclizations of arylacetonitriles with isothiocyanates and ethyl 2-chloro-2-oxoacetate. The products show antibiotic activity against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus.
Albrecht
Uwe
U
Institut für Chemie, Universität Rostock, Albert-Einstein-Str. 3a, 18051 Rostock, Germany.
Gördes
Dirk
D
Schmidt
Enrico
E
Thurow
Kerstin
K
Lalk
Michael
M
Langer
Peter
P
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D013844:Thiazoles