title: [Ultrastructural changes in loach (Misgurnus fossilis L.) embryos under borocin treatment].
abstract: The ultrastructure of embryo cells of the loach (Misgurnus fossilis L.) at the stage of first division of blastomers in control and under the conditions of fluoroquinole borocin treatment has been investigated. The influence of this antibiotic at concentrations 5 and 25 mkg/ml has resulted in significant ultrastructural changes of embryo cells, such as hypertrophy of channels of the smoth and rough endoplasmic reticulum, disorganization of Golgy complex and mitochondrias, destruction of cytoplasm and mitochondrial membranes, rarefaction of cytoplasm and cell oedema. Such changes confirm the toxic influence of borocin on the embryo during early development.
authors.forename: M V
authors.initials: MV
authors.lastname: Tselevych
authors.forename: O R
authors.initials: OR
authors.lastname: Kulachkovs'kyĭ
authors.forename: D I
authors.initials: DI
authors.lastname: Sanahurs'kyĭ
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001757:Blastomeres / Q000187:drug effects / Q000648:ultrastructure; D003531:Cypriniformes / Q000196:embryology*; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian / Q000187:drug effects* / Q000648:ultrastructure*; D004625:Embryo, Nonmammalian / Q000166:cytology / Q000187:drug effects; D024841:Fluoroquinolones / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; C501494:borocin