title: Suzuki coupling of aryl chlorides with phenylboronic acid in water, using microwave heating with simultaneous cooling.
abstract: [reaction: see text]. We present here a methodology for the Suzuki coupling of aryl chlorides with phenylboronic acid using Pd/C as a catalyst, water as a solvent, and microwave heating. We show that simultaneous cooling in conjunction with microwave heating prolongs the lifetime of the aryl chloride substrates during the course of the reaction and, as a result, yields of the desired biaryl as well as overall recovery of material can be increased.
authors.affiliation: Department of Chemistry, University of Connecticut, Unit 3060, 55 North Eagleville Road, Storrs, Connecticut 06269-3060, USA.
authors.forename: Riina K
authors.initials: RK
authors.lastname: Arvela
authors.forename: Nicholas E
authors.initials: NE
authors.lastname: Leadbeater