Cytochrome c and tumor necrosis factor-alpha values in serum and cerebrospinal fluid of patients with influenza-associated encephalopathy.
Cytochrome c and tumor necrosis factor-alpha concentrations were measured in serum and cerebrospinal fluid samples from 10 patients with influenza-associated encephalopathy. In the acute exacerbation phase, serum tumor necrosis factor-alpha and cytochrome c values were high in patients with a poor prognosis. In the convalescent phase, cerebrospinal fluid cytochrome c values increased remarkably in patients with subsequent brain atrophy.
Hosoya
Mitsuaki
M
Department of Pediatrics, Fukushima Medical University School of Medicine, Tokyo, Japan.
Nunoi
Hiroyuki
H
Aoyama
Muneo
M
Kawasaki
Yukihiko
Y
Suzuki
Hitoshi
H
D015415:Biomarkers; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D045305:Cytochromes c' / Q000097:blood* / Q000134:cerebrospinal fluid; D018792:Encephalitis, Viral / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality*; D005260:Female; D006801:Humans; D007223:Infant; D007251:Influenza, Human / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality; D008297:Male; D009975:Orthomyxoviridae / Q000302:isolation & purification*; D011336:Probability; D011379:Prognosis; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis* / Q000134:cerebrospinal fluid
D015415:Biomarkers; D045305:Cytochromes c'; D014409:Tumor Necrosis Factor-alpha