title: A case control study of glycoprotein status in ovarian carcinoma.
abstract: OBJECTIVE
  Ovarian cancer is the leading cause of death due to gynecological malignancies. The aim of our study was to investigate the status of circulating glycoprotein levels in ovarian cancer patients.
  
  
  METHODS
  Thirty ovarian cancer patients and an equal number of age-matched, apparently healthy subjects as controls were involved in the study. Glycoprotein levels, as indicated by the concentration of plasma total sialic acid, protein-bound hexoses, hexosamine and fucose were estimated in circulation of both the ovarian cancer patients and controls.
  
  
  RESULTS
  Significantly elevated levels of plasma total sialic acid, protein-bound hexoses, hexosamine and fucose were observed in ovarian cancer patients as compared to the apparently healthy controls.
  
  
  CONCLUSIONS
  Plasma total sialic acid, protein-bound hexoses, hexosamine and fucose in the circulation of ovarian cancer patients are markedly elevated and the increase in these carbohydrate moieties of glycoproteins reflect the stage of cancer and may be an additional tool in the diagnosis and prognosis of ovarian carcinoma.
authors.affiliation: Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar-608 002, India.
authors.forename: Selvaraj
authors.initials: S
authors.lastname: Aranganathan
authors.forename: Kumarasamy
authors.initials: K
authors.lastname: Senthil
authors.forename: Namasivayam
authors.initials: N
authors.lastname: Nalini
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D005643:Fucose / Q000097:blood; D006023:Glycoproteins / Q000097:blood*; D006595:Hexosamines / Q000097:blood; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000473:pathology*; D011379:Prognosis; D012794:Sialic Acids / Q000097:blood
chemical_list: D014408:Biomarkers, Tumor; D006023:Glycoproteins; D006595:Hexosamines; D012794:Sialic Acids; D005643:Fucose