[Concentration of hydrochloric acid and pepsin in gastric juice in dogs after starvation and refeeding].
Feeding fogs with meat after a 3-day period of starvation increased hydrochloric acid concentration with subsequent return of the parameter to normal values. Under the same conditions, pepsin concentration decreased and raised up after re-feeding. Histamine administration following the starvation decreased hydrochloric acid concentration with subsequent normalising. In three days after re-feeding and histamine administration, pepsin concentration drooped owing, probably, to a decrease of parietal cell H2-receptor affinity to histamine. Pentagastrin administration after the starvation increased hydrochloric acid concentration. The findings suggest G-cell function inhibition occurring after a 3-day starvation which is important for the stomach mucous membrane protection.
Andreeva
Iu V
IuV
Polenov
S A
SA
D000818:Animals; D004285:Dogs; D004435:Eating / Q000502:physiology*; D005215:Fasting / Q000502:physiology*; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology; D006851:Hydrochloric Acid / Q000378:metabolism*; D008297:Male; D010418:Pentagastrin / Q000008:administration & dosage / Q000494:pharmacology*; D010434:Pepsin A / Q000378:metabolism*; D011970:Receptors, Histamine H2 / Q000502:physiology
D011970:Receptors, Histamine H2; D006632:Histamine; D010434:Pepsin A; D010418:Pentagastrin; D006851:Hydrochloric Acid