title: Genetic variants of myeloperoxidase and catechol-O-methyltransferase and breast cancer risk.
abstract: This nested case-control study evaluated the role of polymorphisms in the myeloperoxidase (MPO) and catechol-O-methyltransferase (COMT) genes that modulate oxidative stress in breast cancer risk in a Chinese population. Our results demonstrate that the MPO A/A genotype was associated with a reduced risk of breast cancer (odds ratio (OR) 0.64; 95% confidence interval (CI) 0.11-3.76), whereas there was no overall association of COMT genotype with breast cancer. Of note, an elevated breast cancer risk associated with the increasing numbers of high-risk genotypes of MPO and COMT genes was observed in women with a longer duration between menarche and first full-term pregnancy.
authors.affiliation: School of Public Health, National Defense Medical Center, No. 161, Section 6 Min-Chuan East Road, Taipei 114, Taiwan, Republic of China.
authors.forename: S-C
authors.initials: SC
authors.lastname: Lin
authors.forename: Y-C
authors.initials: YC
authors.lastname: Chou
authors.forename: M-H
authors.initials: MH
authors.lastname: Wu
authors.forename: C-C
authors.initials: CC
authors.lastname: Wu
authors.forename: W-Y
authors.initials: WY
authors.lastname: Lin
authors.forename: C-P
authors.initials: CP
authors.lastname: Yu
authors.forename: J-C
authors.initials: JC
authors.lastname: Yu
authors.forename: S-L
authors.initials: SL
authors.lastname: You
authors.forename: C-J
authors.initials: CJ
authors.lastname: Chen
authors.forename: C-A
authors.initials: CA
authors.lastname: Sun
mesh_terms: D001943:Breast Neoplasms / Q000209:etiology* / Q000235:genetics*; D016022:Case-Control Studies; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D018384:Oxidative Stress; D009195:Peroxidase / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D009195:Peroxidase; D002394:Catechol O-Methyltransferase