Bone marrow stem cell transplantation for cardiac repair.
Cardiomyocytes respond to physiological or pathological stress only by hypertrophy and not by an increase in the number of functioning cardiomyocytes. However, recent evidence suggests that adult cardiomyocytes have the ability, albeit limited, to divide to compensate for the cardiomyocyte loss in the event of myocardial injury. Similarly, the presence of stem cells in the myocardium is a good omen. Their activation to participate in the repair process is, however, hindered by some as-yet-undetermined biological impediments. The rationale behind the use of adult stem cell transplantation is to supplement the inadequacies of the intrinsic repair mechanism of the heart and compensate for the cardiomyocyte loss in the event of injury. Various cell types including embryonic, fetal, and adult cardiomyocytes, smooth muscle cells, and stable cell lines have been used to augment the declining cardiomyocyte number and cardiac function. More recently, the focus has been shifted to the use of autologous skeletal myoblasts and bone marrow-derived stem cells. This review is a synopsis of some interesting aspects of the fast-emerging field of bone marrow-derived stem cell therapy for cardiac repair.
Haider
Husnain Kh
HKh
Dept. of Pathology and Laboratory of Medicine, 231-Albert Sabinway, Univ. of Cincinnati, Cinncinati, OH 45267-0529, USA. haiderkh@ucmail.uc.edu
Ashraf
Muhammad
M
D016026:Bone Marrow Transplantation; D006332:Cardiomegaly / Q000628:therapy*; D006331:Heart Diseases / Q000601:surgery*; D006801:Humans; D032342:Muscle Cells / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000502:physiology / Q000503:physiopathology; D033581:Stem Cell Transplantation