Reactive oxygen species in the control of hypoxia-inducible factor-mediated gene expression.
Reactive oxygen species (ROS) have long been considered as cytotoxic. However, recent evidence indicates a prominent role of ROS as signaling molecules in the response to hormones, growth and coagulation factors, cytokines and other factors as well as to changes in oxygen tension. The hypoxia-inducible transcription factors (HIFs) are key players in the cellular response to changes in oxygen tension. Recently, HIFs have also been shown to respond to the above-mentioned non-hypoxic stimuli. In this article, the role of ROS in the regulation of HIF-1 under hypoxic and non-hypoxic conditions is summarized.
Kietzmann
Thomas
T
Faculty of Chemistry, Department of Biochemistry, Erwin-Schrödinger-Strasse, University of Kaiserslautern, 67663 Kaiserslautern, Germany.
Görlach
Agnes
A
D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D000860:Hypoxia / Q000201:enzymology / Q000378:metabolism*; D051793:Hypoxia-Inducible Factor 1 / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D017382:Reactive Oxygen Species / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D017382:Reactive Oxygen Species