Development and validation of an UV spectrophotometric method for determination of gatifloxacin in tablets.
A simple, sensitive and accurate spectrophotometric method was developed for the assay of gatifloxacin in raw material and tablets. Validation of the method yielded good results concerning range, linearity, precision and accuracy. The absorbance was measured at 287 nm for gatifloxacin tablet solutions. The linearity range was found to be 4.0-14.0 microg/mL for gatifloxacin. It was also found that the excipients in the commercial tablets did not interfere with the method.
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Programa de Pós-graduação em Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista, Araraquara SP, Brazil.
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D000890:Anti-Infective Agents / Q000032:analysis*; D002138:Calibration; D024841:Fluoroquinolones / Q000032:analysis*; D000077734:Gatifloxacin; D012015:Reference Standards; D015203:Reproducibility of Results; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D013607:Tablets; D000077734:Gatifloxacin