[The genes related to the effects of vitamin D on muscle and bone].
Vitamin D is most frequently used as a drug for osteoporosis in Japan, and its effects on the maintenance of bone mineral density and inhibition of fracture risk have been shown. Recently, the actions of vitamin D on muscle have been elaborated, and its prevention of falls is noted. Active vitamin D modulates several genes in muscle and bones. The studies using vitamin D receptor deletion mice revealed that active vitamin D modulates the genes related to muscle differentiation and bone resorption.
Kaji
Hiroshi
H
Division of Endocrinology/Metabolism, Neuology and Hematology/Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine.
Sugimoto
Toshitsugu
T
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects*; D006801:Humans; D051379:Mice; D009132:Muscles / Q000187:drug effects*; D010024:Osteoporosis / Q000188:drug therapy; D018167:Receptors, Calcitriol / Q000235:genetics; D014807:Vitamin D / Q000494:pharmacology* / Q000627:therapeutic use
D018167:Receptors, Calcitriol; D014807:Vitamin D