title: Fate of eprinomectin in goat milk and cheeses with different ripening times following pour-on administration.
abstract: The distribution of eprinomectin in goat milk and cheeses (cacioricotta, caciotta, caprilisco) with different ripening times following a pour-on administration at a single dose rate (500 microg/kg of body weight) and a double dose rate (1,000 microg/kg of body weight) to goats with naturally occurring infections of gastrointestinal nematodes was studied. Milk residues of eprinomectin reached a maximum of 0.55+/-0.18 microg/kg and 1.70+/-0.31 microg/kg at the single and double doses, respectively. The drug concentrations decreased progressively until the fifth day after treatment, when they were less than the detection limit at both dose rates. The eprinomectin levels measured in all cheese types (both treatments) were higher than those recovered in milk at all the sampling times. In caciotta cheeses, the eprinomectin residues levels were constantly higher than other cheeses. With the exception of cheeses made with milk the first day after treatment, eprinomectin concentrations were nearly constant up to the fourth day then decreased by the fifth and sixth days after treatment. In all cases, at both the single and double dosages, the maximum level of eprinomectin residues in goat milk and cheeses remained below the maximum residual level of 20 microg/liter permitted for lactating cattle.
authors.affiliation: Dipartimento di Scienze Zootecniche e Ispezione degli Alimenti, Sezione Ispezione, Facoltà di Medicina Veterinaria, Università degli Studi di Napoli, Federico II, Napoli 80137, Italy. anastasi@unina.it
authors.forename: Aniello
authors.initials: A
authors.lastname: Anastasio
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Veneziano
authors.forename: Emiliana
authors.initials: E
authors.lastname: Capurro
authors.forename: Laura
authors.initials: L
authors.lastname: Rinaldi
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Cortesi
authors.forename: Roberto
authors.initials: R
authors.lastname: Rubino
authors.forename: Martin
authors.initials: M
authors.lastname: Danaher
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cringoli
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000871:Anthelmintics / Q000302:isolation & purification / Q000493:pharmacokinetics*; D002611:Cheese / Q000032:analysis*; D004305:Dose-Response Relationship, Drug; D004350:Drug Residues / Q000032:analysis; D005260:Female; D005506:Food Contamination / Q000032:analysis; D006041:Goats / Q000378:metabolism*; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000493:pharmacokinetics*; D008892:Milk / Q000737:chemistry*; D011897:Random Allocation; D013997:Time Factors
chemical_list: D000871:Anthelmintics; D007559:Ivermectin; C101434:eprinomectin