Hypertriglyceridemia is associated with prebeta-HDL concentrations in subjects with familial low HDL.
Prebeta-HDL particles act as the primary acceptors of cellular cholesterol in reverse cholesterol transport (RCT). An impairment of RCT may be the reason for the increased risk of coronary heart disease (CHD) in subjects with familial low HDL. We studied the levels of serum prebeta-HDL and the major regulating factors of HDL metabolism in 67 subjects with familial low HDL and in 64 normolipidemic subjects. We report that the subjects with familial low HDL had markedly reduced prebeta-HDL concentrations compared with the normolipidemic subjects (17.4 +/- 7.2 vs. 23.4 +/- 7.8 mg apolipoprotein A-I/dl; P < 0.001). A positive correlation was observed between prebeta-HDL concentration and serum triglyceride (TG) level (r = 0.334, P = 0.006). In addition, serum TG level was found to be the strongest predictor of prebeta-HDL concentration in subjects with familial low HDL. The activities of cholesteryl ester transfer protein and hepatic lipase were markedly increased in subjects with familial low HDL without a significant correlation to prebeta-HDL concentration. Our results support the hypothesis that impaired RCT is one mechanism behind the increased risk for CHD in subjects with familial low HDL.
Söderlund
Sanni
S
Division of Cardiology, Department of Medicine, University of Helsinki, Helsinki, Finland.
Soro-Paavonen
Aino
A
Ehnholm
Christian
C
Jauhiainen
Matti
M
Taskinen
Marja-Riitta
MR
D000328:Adult; D002352:Carrier Proteins / Q000378:metabolism; D016022:Case-Control Studies; D002784:Cholesterol / Q000378:metabolism; D053480:Cholesterol Ester Transfer Proteins; D003327:Coronary Disease / Q000097:blood / Q000209:etiology; D005192:Family Health; D006023:Glycoproteins / Q000378:metabolism; D053442:High-Density Lipoproteins, Pre-beta; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood*; D008049:Lipase / Q000378:metabolism; D008075:Lipoproteins, HDL / Q000097:blood* / Q000737:chemistry / Q000378:metabolism; D008875:Middle Aged; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D006023:Glycoproteins; D053442:High-Density Lipoproteins, Pre-beta; C504173:LIPC protein, human; D008075:Lipoproteins, HDL; D014280:Triglycerides; D002784:Cholesterol; D008049:Lipase