title: Oxidative stress in pericardial fluid and plasma and its association with ventricular function.
abstract: There are no studies evaluating oxidative stress markers both in pericardial fluid and plasma and whether they correlate with cardiac function indexes. The purpose of the study was to investigate whether oxidative stress markers in pericardial fluid and plasma are associated with left ventricular function.
  
  
  RESULTS
  Twenty-eight consecutive patients (class I or II NYHA) scheduled for myocardial revascularization, valve replacement, valve repair or closure of atrial septal defect. Plasma and pericardial fluid were collected and malondialdehyde, catalase, superoxide dismutase and glutathione peroxidase were determined. Left ventricular ejection fraction, left ventricular end diastolic diameter and left ventricular end systolic diameter were determined as echocardiographic indexes of ventricular function. We found that oxidative stress determined by a simple malondialdehyde (MDA) assay, correlated in plasma and pericardial fluid, and this parameter was associated with left ventricular end systolic diameter.
  
  
  CONCLUSIONS
  Plasma and pericardial fluid malondialdehyde levels can be used as an early marker of ventricular dysfunction.
authors.affiliation: Department of Cardiovascular Diseases, Faculty of Medicine, University of Chile. Av. Salvador 364 Santiago, Chile. vukasovic@terra.cl
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Vukasovic
authors.forename: Francisco
authors.initials: F
authors.lastname: Moraga
authors.forename: Guillermo
authors.initials: G
authors.lastname: Díaz-Araya
authors.forename: Eduardo
authors.initials: E
authors.lastname: Turner
authors.forename: Mario
authors.initials: M
authors.lastname: Chiong
authors.forename: Polentzi
authors.initials: P
authors.lastname: Uriarte
authors.forename: Fernando
authors.initials: F
authors.lastname: Florenzano
authors.forename: Sergio
authors.initials: S
authors.lastname: Lavandero
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D010490:Pericardial Effusion / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000097:blood; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism*
chemical_list: D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase