The metastasis associated protein S100A4: role in tumour progression and metastasis.
The metastasis associated protein S100A4 is a small calcium binding protein that is associated with metastatic tumors and appears to be a molecular marker for clinical prognosis. Below we discuss its biochemical properties and possible cellular functions in metastasis including cell motility, invasion, apoptosis, angiogenesis and differentiation.
Helfman
D M
DM
Department of Cell Biology and Anatomy, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL 33136, USA. dhelfman@med.miami.edu
Kim
E J
EJ
Lukanidin
E
E
Grigorian
M
M
D002465:Cell Movement; D002471:Cell Transformation, Neoplastic; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis / Q000235:genetics* / Q000503:physiopathology*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology*; D009389:Neovascularization, Pathologic; D010641:Phenotype; D011379:Prognosis; D000071999:S100 Calcium-Binding Protein A4; D009418:S100 Proteins / Q000235:genetics* / Q000502:physiology*
D000071999:S100 Calcium-Binding Protein A4; D009418:S100 Proteins; C077591:S100A4 protein, human