title: New approach to 3-oxo-4-aza-5alpha-androst-1-ene-17beta-(N-tert-butylcarboxamide).
abstract: We describe the synthesis of 3-oxo-4-aza-5alpha-androst-1-ene-17beta-(N-tert-butylcarboxamide) (finasteride) from 4-androstene-3,17-dione (AD) in seven steps in an overall yield of 18.6% via oxidation, ammoniumation, dehydration, and dehydrogenation.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei, PR China. ioc@whu.edu.cn
authors.forename: Zhong-Xing
authors.initials: ZX
authors.lastname: Jiang
authors.forename: Jing-Quan
authors.initials: JQ
authors.lastname: Ye
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
authors.forename: Ying-Sheng
authors.initials: YS
authors.lastname: Zhao
mesh_terms: D058891:5-alpha Reductase Inhibitors; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D018120:Finasteride / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D058891:5-alpha Reductase Inhibitors; D004791:Enzyme Inhibitors; D018120:Finasteride