title: [Expressions of transforming growth factor-beta1 and collagen IV in renal tissues of patients with chronic allograft nephropathy].
abstract: OBJECTIVE
  To investigate the expressions of transforming growth factor (TGF)-beta1 and collagen IV in the renal tissues of patients with chronic allograft nephropathy (CAN).
  
  
  METHODS
  Immunohistochemical method and computer-assisted image analysis system were used to detect the expressions of TGF-beta1 and collagen IV in the renal tissues of patients with CAN, and the association between TGF-beta1 and collagen IV expressions as well as that between their expressions and the pathological grading of CAN were analyzed.
  
  
  RESULTS
  The expressions of TGF-beta1 and collagen IV were significantly higher in the renal tissues of the patients than in normal renal tissues (P<0.001), and the expressions tended to increase with the pathological grades of CAN; TGF-beta1 and collagen IV expressions in both the renal glomeruli and the tubulointerstitium were in patients with CAN positively correlated with normal renal tissues (r=0.943, P<0.001; r=0.910, P<0.001).
  
  
  CONCLUSIONS
  Abnormal collagen IV deposition is one of the major factors associated with renal fibrosis in CAN, and TGF-beta1 might play an important role in renal fibrosis in CAN through up-regulation of collagen IV in the renal tissues.
authors.affiliation: Department of Kidney Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. xiangzi4318@sina.com
authors.forename: Cong-xiang
authors.initials: CX
authors.lastname: Han
authors.forename: Li-xin
authors.initials: LX
authors.lastname: Yu
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
authors.forename: Qing-xiang
authors.initials: QX
authors.lastname: Xie
authors.forename: Yi-bin
authors.initials: YB
authors.lastname: Wang
authors.forename: Wen-feng
authors.initials: WF
authors.lastname: Deng
authors.forename: Xiao-you
authors.initials: XY
authors.lastname: Liu
authors.forename: Jing-hua
authors.initials: JH
authors.lastname: Zeng
mesh_terms: D002908:Chronic Disease; D024141:Collagen Type IV / Q000096:biosynthesis* / Q000235:genetics; D005355:Fibrosis / Q000378:metabolism; D006084:Graft Rejection / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D007674:Kidney Diseases / Q000378:metabolism* / Q000473:pathology; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology; D011183:Postoperative Complications / Q000276:immunology / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000096:biosynthesis* / Q000235:genetics; D014184:Transplantation, Homologous / Q000276:immunology / Q000473:pathology
chemical_list: D024141:Collagen Type IV; D016212:Transforming Growth Factor beta