title: [Computed tomographic criteria as expected effect to inhaled nitric oxide in patients with severe acute respiratory distress syndrome].
abstract: OBJECTIVE
  Inhaled nitric oxide (iNO) is an effective therapy for severe hypoxemia in most patients with acute respiratory distress syndrome (ARDS). For unknown reason, a subset of ARDS patients does not respond favorably to iNO therapy. We hypothesized that radiological manifestation of lung injury may be related to iNO response.
  
  
  METHODS
  We retrospectively analyzed data from n = 25 ARDS patients who received iNO, and underwent chest CT within 72 h prior to inhaled treatment. The morphology of coherently pathologic lung tissue was characterized by the length of the borderline between consolidated, infiltrated and atelectatic lung tissue and radiologically normal lung tissue. This quantity was expressed as relative fraction of the visceral pleural circumference and averaged over all CT slices. Furthermore we semiquantitatively determined the total volume of consolidated lung tissue as part of the whole lung.
  
  
  RESULTS
  In n = 6 non-responders to iNO (DeltaPaO2 < 10 %), we determined a short relative borderline between normal and consolidated lung tissue due to the presence of large and coherently consolidated lung regions. In n = 19 iNO responders (DeltaPaO2 > 10 %), we found significantly less coherently consolidated lung tissue evidenced by an increased relative borderline when compared to iNO non-responders (0.09 +/- 0.02 vs. 0.1 +/- 0.01; P < 0.05). Moreover, there was a moderate and significant correlation between DeltaPaO2 induced by iNO and the relative borderline in all patients studied (R = 0.59; P < 0.05). Total fraction of consolidated lung tissue volume was not different between iNO non-responders and responders (60 +/- 3 % vs. 54 +/- 2 % n. s.).
  
  
  CONCLUSIONS
  Our data demonstrate that the gross morphological distribution of pathological lung tissue influences iNO response in ARDS. Inhaled NO was most beneficial in injured lungs characterized by many small consolidated areas surrounded by normal lung tissue. The increased borderline between pathologic and normal lung tissue offers additional possibility for iNO to divert blood flow from shunt areas to ventilated lung regions, which consequently improves arterial oxygenation.
authors.affiliation: Klinik für Strahlenheilkunde, Charité, Campus Virchow-Klinikum, Universitätsmedizin Berlin, Berlin. r.roettgen@t-online.de
authors.forename: R
authors.initials: R
authors.lastname: Röttgen
authors.forename: T
authors.initials: T
authors.lastname: Busch
authors.forename: H
authors.initials: H
authors.lastname: Lohbrunner
authors.forename: H
authors.initials: H
authors.lastname: Einfeld
authors.forename: M
authors.initials: M
authors.lastname: Deja
authors.forename: R J
authors.initials: RJ
authors.lastname: Schroeder
authors.forename: S
authors.initials: S
authors.lastname: Weber-Carstens
authors.forename: K J
authors.initials: KJ
authors.lastname: Falke
authors.forename: R
authors.initials: R
authors.lastname: Felix
authors.forename: U
authors.initials: U
authors.lastname: Kaisers
mesh_terms: D000328:Adult; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000008:administration & dosage*; D010100:Oxygen / Q000097:blood; D013902:Radiography, Thoracic; D012128:Respiratory Distress Syndrome / Q000097:blood / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D012138:Respiratory Therapy; D012189:Retrospective Studies; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D001993:Bronchodilator Agents; D009569:Nitric Oxide; D010100:Oxygen