Development of a resorbable macroporous cellulosic material used as hemostatic in an osseous environment.
The control of bleeding is a frequently encountered therapeutic problem, particularly during dental surgery. The most efficient substances used to resolve this problem are not risk-free because of their animal or human origins, so cellulosic materials are potentially of interest. The aim of this study was to develop a resorbable macroporous cellulosic material for use as a resorbable hemostatic agent in bone sites. The degradation and the cytocompatibility of the cellulosic material versus controls were evaluated and its behaviour in vivo was studied. An original process using calcium carbonate powder as inverse matrix was used to develop a macroporous material. In order to predegrade the cellulosic material for hemostatic use, oxidation was performed with periodate. A dialdehyde component unstable at physiological pH was thus obtained. The material was found to have cytotoxicity, biocompatibility, and resorption properties similar to control but its hemostatic power was higher.
Laurence
S
S
INSERM-U.577, Université Victor Segalen Bordeaux 2, 146 rue Léo-Saignat, 33076 Bordeaux, France. seblaurel@wanadoo.fr
Bareille
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R
Baquey
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Fricain
J C
JC
D020341:Absorbable Implants; D000447:Aldehydes / Q000737:chemistry; D000818:Animals; D001672:Biocompatible Materials; D001698:Biomedical Engineering; D001835:Body Weight; D001854:Bone Marrow Cells / Q000166:cytology; D001861:Bone Regeneration; D001862:Bone Resorption; D018786:Bone Substitutes; D001842:Bone and Bones / Q000187:drug effects*; D002119:Calcium Carbonate / Q000494:pharmacology; D002241:Carbohydrates / Q000737:chemistry; D002478:Cells, Cultured; D002482:Cellulose / Q000737:chemistry*; D005781:Gelatin Sponge, Absorbable; D020723:Glucuronic Acid / Q000737:chemistry; D006016:Glycolates / Q000737:chemistry; D006487:Hemostasis; D006490:Hemostatics / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D011817:Rabbits; D013997:Time Factors
D000447:Aldehydes; D001672:Biocompatible Materials; D018786:Bone Substitutes; D002241:Carbohydrates; D006016:Glycolates; D006490:Hemostatics; C031149:glycolic acid; D020723:Glucuronic Acid; D002482:Cellulose; D002119:Calcium Carbonate