title: MR microscopy of the parotid glands in patients with Sjogren's syndrome: quantitative MR diagnostic criteria.
abstract: OBJECTIVE
  MR imaging of the salivary glands has been applied to the diagnosis of Sjogren's syndrome; however, the diagnosis remains qualitative. We sought to establish and evaluate quantitative MR imaging criteria for the diagnosis of Sjogren's syndrome.
  
  
  METHODS
  MR imaging with a 47-mm microscopy coil was performed in 83 patients with xerostomia (55 patients with Sjogren's syndrome, 28 without Sjogren's syndrome). MR images were obtained by T1-weighted and fat-suppressed T2-weighted imaging and by MR sialography of the parotid glands. MR imaging findings of the parotid glands in Sjogren's syndome included increases in fat areas and decreases in intact lobule areas. These MR images were morphometrically analyzed for the diagnostic criteria.
  
  
  RESULTS
  MR imaging with a microscopy coil demonstrated well the details of the damaged parotid glands in patients with xerostomia. Quantitative MR imaging of fat, intact gland lobule, and number of sialoectatic foci significantly and highly correlated with severity of disease. Receiver operating characteristic (ROC) curve analysis demonstrated that quantitative MR imaging yielded high diagnostic ability in differentiating patients with xerostomia who have Sjogren's syndrome from those without Sjogren's syndrome, with areas under the ROC curve of 0.94 for fat area, 0.98 for intact lobule area, and 0.91 for number of sialoectatic foci. The best cutoff points by quantitative MR imaging were each associated with high sensitivity and specificity, and, when used in combination, yielded 96% sensitivity and 100% specificity.
  
  
  CONCLUSIONS
  Quantitative MR imaging effectively differentiated the parotid glands in patients with xerostomia who have Sjogren's syndrome from those without the syndrome and provided criteria for staging the gland disease.
authors.affiliation: Department of Radiology and Cancer Biology, Nagasaki University School of Dentistry, Nagasaki, Japan.
authors.forename: Yukinori
authors.initials: Y
authors.lastname: Takagi
authors.forename: Misa
authors.initials: M
authors.lastname: Sumi
authors.forename: Tadateru
authors.initials: T
authors.lastname: Sumi
authors.forename: Yoko
authors.initials: Y
authors.lastname: Ichikawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000706:statistics & numerical data; D008297:Male; D008853:Microscopy; D008875:Middle Aged; D010306:Parotid Gland / Q000473:pathology*; D012859:Sjogren's Syndrome / Q000473:pathology*