title: [Early vs conservative treatment of acute cholecystitis. Personal experience and review of the literature].
abstract: OBJECTIVE
  The aim of this retrospective study was to compare the results of early cholecystectomy and conservative treatment in acute cholecystitis.
  
  
  METHODS
  From January 1998 to December 2002, 134 patients were admitted to our Department with the diagnosis of acute cholecystitis. Eighty-nine patients (66%, Group 1) were cured with conservative treatment (i.e. fast, broad-spectrum antibiotics, fluid and analgesic drugs), 45 patients (34%, Group 2) were submitted to early cholecystectomy. The 2 groups were matched for age, sex, laboratory results and echographic findings.
  
  
  RESULTS
  The morbidity was 32.5% in Group 1 versus 15.5% in Group 2 (p < 0.05). Mean hospital stay was 18 days in Group 1 as compared to 10.5 days in Group 2 (p < 0.05). At follow-up (12 months) the mean period before starting again a normal working and social life was 57 days in Group 1 and 33 days in Group 2.
  
  
  CONCLUSIONS
  The results of this study showed that early cholecystectomy was the gold standard in the treatment of acute cholecystitis, since it reduces morbidity, hospital stay and absence from working and social life in a statistically important way.
authors.affiliation: Department of General Surgery and Surgical Specialties, University of Siena, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Ranalli
authors.forename: W
authors.initials: W
authors.lastname: Testi
authors.forename: A
authors.initials: A
authors.lastname: Genovese
authors.forename: C
authors.initials: C
authors.lastname: Bing
authors.forename: S
authors.initials: S
authors.lastname: Tumbiolo
authors.forename: E
authors.initials: E
authors.lastname: Andolfi
authors.forename: F
authors.initials: F
authors.lastname: Tani
authors.forename: G
authors.initials: G
authors.lastname: Botta
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000700:Analgesics / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002763:Cholecystectomy; D041881:Cholecystitis, Acute / Q000175:diagnosis / Q000188:drug therapy / Q000401:mortality / Q000601:surgery* / Q000628:therapy; D004630:Emergencies; D005260:Female; D005440:Fluid Therapy; D005500:Follow-Up Studies; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D000700:Analgesics; D000900:Anti-Bacterial Agents