HLA class II involvement in HIV-associated Toxoplasmic encephalitis development.
A total of 220 individuals were included in this study, 112 HIV-seronegative healthy individuals and 108 HIV-1-infected patients involving: 18 AIDS patients with Toxoplasmic encephalitis (AIDS-TE), 49 AIDS patients without TE, and 41 asymptomatic patients, were genotyping for DR and DQ loci by molecular biology techniques. Fisher's Exact test was used for statistical analysis. HLA-DQB*0402 and DRB1*08 alleles were associated with a high risk to develop opportunistic infections with neurological involvement, mainly Toxoplasma encephalitis in relationship with subjects healthy (OR = 20.43; Pc = 7.0 x 10(-6) and OR = 11; Pc = 2.6 x 10(-4), respectively); in relationship with AIDS no TE (OR = 6.98; Pc = 0.028 and OR = 4.85; P = 0.012, Pc = 0.14) and with patients in asymptomatic stage (OR = 61.50, Pc = 8.4 x 10(-6) and OR = 19.38; Pc = 3.9 x 10(-4)), respectively.


CONCLUSIONS
It was concluded that the presence of HLA-DQB*0402 and DRB1*08 alleles in HIV-1-positive patients could be considered risk factors for developing neurological opportunistic infections, mainly Toxoplasmic encephalitis.
Habegger de Sorrentino
Alicia
A
Servicio de Histocompatibilidad e Inmunogenética, Servicio de Inmunología y Servicio de Infectología. Hospital Julio C. Perrando, Resistencia, Chaco, Argentina. sorro@arnet.com.ar
López
Roxana
R
Motta
Patricia
P
Marinic
Karina
K
Sorrentino
Adrián
A
Iliovich
Ernesto
E
Rubio
Andrea E
AE
Quarleri
Jorge
J
Salomón
Horacio
H
D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000235:genetics*; D001118:Argentina / Q000453:epidemiology; D016022:Case-Control Studies; D004660:Encephalitis / Q000150:complications / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D015497:HIV-1; D006683:HLA-DQ Antigens / Q000145:classification / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000145:classification / Q000235:genetics*; D006801:Humans; D010641:Phenotype; D016781:Toxoplasmosis, Cerebral / Q000150:complications / Q000235:genetics*
D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C057615:HLA-DQbeta antigen; D006684:HLA-DR Antigens