Estradiol administration mediates the inflammatory response to formalin in female rats.
Female rats demonstrate higher pain sensitivity than do males in various nociceptive assays of inflammation. In the present study, we found that estradiol (20%) replacement in ovariectomized rats attenuated the chronic phase of the formalin response but only at high formalin concentrations thought to rely on peripheral inflammation. An inactive isomer of estradiol, alpha-estradiol, failed to result in the same attenuation (P > 0.05). Our results suggest that estradiol's actions in inflammatory responses are mediated through genomic estrogen receptor-mediated mechanisms.
Kuba
Tzipora
T
Department of Psychology, Biopsychology Subprogram, Hunter College, The City University of New York, 695 Park Avenue, New York, NY 10021, USA.
Kemen
Lynne M
LM
Quinones-Jenab
Vanya
V
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000097:blood / Q000494:pharmacology*; D004195:Disease Models, Animal; D004967:Estrogens / Q000097:blood / Q000494:pharmacology*; D030762:Estrous Cycle / Q000502:physiology*; D005260:Female; D007249:Inflammation / Q000139:chemically induced / Q000378:metabolism*; D008597:Menstrual Cycle / Q000378:metabolism; D009475:Neurons, Afferent / Q000502:physiology; D010052:Ovariectomy; D010146:Pain / Q000378:metabolism* / Q000503:physiopathology; D010147:Pain Measurement; D017288:Pain Threshold / Q000187:drug effects* / Q000502:physiology; D010525:Peripheral Nerves / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011960:Receptors, Estrogen / Q000819:agonists / Q000378:metabolism; D012727:Sex Characteristics
D000893:Anti-Inflammatory Agents; D004967:Estrogens; D011960:Receptors, Estrogen