title: Ray-fin fish tetraploidization gave rise to pufferfish duplicates of NPY and PYY, but zebrafish NPY duplicate was lost.
abstract: We have used sequence information and gene location to identify NPY family genes in the pufferfish, Takifugu rubripes (fugu), and zebrafish. Fugu has two copies of NPY, presumably resulting from the ray-fin fish tetraploidization. Zebrafish has probably lost one of the copies. Both species have two copies of PYY, the second of which was previously named PY. The two fugu NPY genes are predominantly expressed in brain. The two PYY genes are expressed in a broad range of tissues including brain and gonads. Thus, the NPY system appears to be more complex in teleosts than in tetrapods.
authors.affiliation: Department of Neuroscience, Uppsala University, Sweden.
authors.forename: Görel
authors.initials: G
authors.lastname: Sundström
authors.forename: Tomas A
authors.initials: TA
authors.lastname: Larsson
authors.forename: Sydney
authors.initials: S
authors.lastname: Brenner
authors.forename: Byrappa
authors.initials: B
authors.lastname: Venkatesh
authors.forename: Dan
authors.initials: D
authors.lastname: Larhammar
mesh_terms: D000818:Animals; D020131:Genes, Duplicate / Q000235:genetics*; D006801:Humans; D009478:Neuropeptide Y / Q000235:genetics*; D019894:Peptide YY / Q000235:genetics*; D011123:Polyploidy; D013045:Species Specificity; D023741:Takifugu / Q000235:genetics*; D015027:Zebrafish / Q000235:genetics*
chemical_list: D009478:Neuropeptide Y; D019894:Peptide YY