Detection through screening of maternal thyrotoxicosis induced central hypothyroidism in newborns.
Use of a third generation TSH assay enabled extremely low values of TSH to be detected through newborn screening. The use of a supplemental free thyroxine improved testing specificity. The hypothyroidism observed is believed to be secondary to suppression of the hypothalamic-pituitary-thyroid axis by placentally transferred maternal thyroxine.
Joseph
Roy
R
Department of Pediatrics, National University of Singapore.
Lee
Yung Seng
YS
Ng
Steven Chin Yuen
SC
Loke
Kah Yin
KY
D003409:Congenital Hypothyroidism; D005260:Female; D005312:Fetal Blood; D006403:Hematologic Tests; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis* / Q000209:etiology; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D015997:Neonatal Screening / Q000379:methods*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood; D012680:Sensitivity and Specificity; D013971:Thyrotoxicosis / Q000097:blood / Q000150:complications*; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000008:administration & dosage
D013972:Thyrotropin; D013974:Thyroxine