title: Rosai-Dorfman disease presenting as multiple soft tissue masses.
abstract: Rosai-Dorfman disease is a rare clinical disorder which may present in many forms. While classically a disease of lymph nodes, soft tissue involvement is fairly common. Soft tissue involvement can occur without any lymphatic or systemic involvement, and may be difficult to diagnose. We describe a patient presenting with multiple soft tissue masses which on biopsy proved to be isolated cutaneous Rosai-Dorfman disease. MR imaging showed two well-defined nonspecific superficial masses that enhanced intensely. Review of the literature suggests that when this disease presents in soft tissue, multiple foci of involvement may be common. Although rare, Rosai-Dorfman disease should be considered in the differential diagnosis of patients presenting with multiple soft tissue masses.
authors.affiliation: Department of Radiology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224-3899, USA. kransdorf.mark@mayo.edu
authors.forename: Phillip M
authors.initials: PM
authors.lastname: Young
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Kransdorf
authors.forename: H Thomas
authors.initials: HT
authors.lastname: Temple
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Mousavi
authors.forename: Philip G
authors.initials: PG
authors.lastname: Robinson
mesh_terms: D000328:Adult; D005260:Female; D015618:Histiocytosis, Sinus / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D006801:Humans; D011859:Radiography; D040521:Subcutaneous Tissue; D013848:Thigh