Effects of an intense training on functional activity of 5-HT(1B) receptors in human peripheral blood lymphocytes.
Serotonin (5-HT) is a neurotransmitter and an immune modulator. At the periphery, the serotonergic system appears to possess a regulatory activity via 5-HT 1B receptors. The present study investigated the effects of a 5-day military course following 3 weeks of combat training on the functional activity of 5-HT 1B/1D receptors in peripheral blood lymphocytes of male soldiers. The results of [35S]GTPgammaS binding assays showed that h5-HT 1B/1D receptors were desensitized after the training program, although serum 5-HT was unchanged. These data suggest the existence of a control on T cells mediated through h5-HT 1B/1D receptors leading cytokine production modulation after a physical training.
Chennaoui
M
M
Département de Physiologie Intégrée, IMASSA, BP 73, 91223 Brétigny-sur-Orge, France. mchennaoui@imassa.fr
Drogou
C
C
Gomez-Merino
D
D
Guezennec
C Y
CY
D000328:Adult; D015308:Anaerobic Threshold / Q000502:physiology; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D016207:Cytokines / Q000096:biosynthesis; D016244:Guanosine 5'-O-(3-Thiotriphosphate); D006801:Humans; D008297:Male; D008889:Military Personnel; D009479:Neuropeptides / Q000378:metabolism; D009842:Oligopeptides / Q000378:metabolism; D010809:Physical Fitness / Q000502:physiology*; D044302:Receptor, Serotonin, 5-HT1B / Q000097:blood*; D012701:Serotonin / Q000097:blood; D013601:T-Lymphocytes / Q000378:metabolism* / Q000502:physiology*
C102005:5-HT-moduline; D016207:Cytokines; D009479:Neuropeptides; D009842:Oligopeptides; D044302:Receptor, Serotonin, 5-HT1B; D012701:Serotonin; D016244:Guanosine 5'-O-(3-Thiotriphosphate)