Hantavirus infection in Thailand: first clinical case report.
This study involved 115 cases of Fever of Unknown Origin (FUO) in patients who were admitted to the Department of Medicine, Siriraj Hospital from May 1999 to November 2000. Among the patient sera screened by ELISA for IgG Hantavirus, five were positive for IgG Hantavirus-reacting antibodies and eight tested positive for IgM Hantavirus-reacting antibodies. One serum had both IgG and IgM antibodies. The patient exhibited acute encephalitic febrile illness, thrombocytopenia, high AST and ALT levels, and prolonged coagulation time. It appears that a form of the Hantaan virus is circulating in Thailand, which can infect humans and be pathogenic in some instances.
Suputthamongkol
Yupin
Y
Department of Medicine at Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Nitatpattana
Narong
N
Chayakulkeeree
Methee
M
Palabodeewat
Somnuek
S
Yoksan
Sutee
S
Gonzalez
Jean-Paul
JP
D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood; D015897:Comorbidity; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005335:Fever of Unknown Origin / Q000209:etiology*; D006476:Orthohantavirus / Q000276:immunology* / Q000302:isolation & purification; D018778:Hantavirus Infections / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D006760:Hospitalization; D006801:Humans; D007074:Immunoglobulin G; D012698:Serologic Tests; D013785:Thailand
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase