Prostaglandin D2 inhibits IgE-mediated scratching by suppressing histamine release from mast cells.
Effects of prostaglandin (PG) D(2), PGE(2), and PGI(2) on itch-associated scratching responses of mice and histamine release from the rat basophilic leukemia cell line RBL-2H3 were examined. PGD(2) and ketotifen but not PGE(2) and PGI(2) suppressed the scratching caused by ovalbumin injected into ovalbumin-sensitized mice. Ketotifen also suppressed compound 48/80-induced scratching but not PGD(2), PGE(2), and PGI(2). In vitro, PGD(2) suppressed the antigen-induced histamine release from RBL-2H3 cells, but PGE(2) and PGI(2) did not. These findings suggest that PGD(2) specifically suppressed IgE-mediated scratching by inhibiting IgE-mediated histamine release from mast cells.
Hashimoto
Yuki
Y
Department of Pharmacology Laboratory, Medicinal Research Laboratory, Taisho Pharmaceutical Co., Ltd., Saitama 331-9530, Japan
Arai
Iwao
I
Tanaka
Makoto
M
Nakaike
Shiro
S
D000818:Animals; D045744:Cell Line, Tumor; D006636:Histamine Release / Q000187:drug effects* / Q000502:physiology; D007073:Immunoglobulin E / Q000633:toxicity*; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D015230:Prostaglandin D2 / Q000494:pharmacology / Q000627:therapeutic use*; D011537:Pruritus / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D051381:Rats
D007073:Immunoglobulin E; D015230:Prostaglandin D2