title: Altered luteinizing hormone and testosterone secretion in middle-aged obese men with obstructive sleep apnea.
abstract: OBJECTIVE
  To elucidate the causes for the decline in testosterone levels observed in men with obstructive sleep apnea (OSA).
  
  
  METHODS
  We determined serum luteinizing hormone (LH) and testosterone levels every 20 minutes between 7 pm and 7 am with simultaneous sleep recordings in five obese middle-aged men with OSA, in five age- and BMI-matched controls, and in six lean young healthy men.
  
  
  RESULTS
  The mean and area under the curve (AUC) values of LH and testosterone were significantly lower in men with OSA compared with controls. Young controls had significantly more testosterone pulses of shorter interpulse duration than OSA subjects and middle-aged controls. After adjusting for age and BMI, the three groups differed in mean and AUC values of LH and testosterone. Analysis of covariance, using BMI as a covariate, revealed a statistically significant group effect on mean and AUC testosterone values (p = 0.03; p < 0.003, respectively). Eliminating young controls, there was a significant positive correlation between the amount of LH and testosterone secreted at night. After partialling out age alone and BMI alone, the mean LH and mean testosterone were still positively correlated.
  
  
  CONCLUSIONS
  Thus, OSA is associated with decreased pituitary-gonadal function. The decline in testosterone concentrations is due to obesity and advanced age and to a lesser degree to sleep fragmentation and hypoxia.
authors.affiliation: Endocrine Institute, Haemek Medical Center, Afula 18101, Israel. luboshitzky-r@clalit.org
authors.forename: Rafael
authors.initials: R
authors.lastname: Luboshitzky
authors.forename: Lena
authors.initials: L
authors.lastname: Lavie
authors.forename: Zila
authors.initials: Z
authors.lastname: Shen-Orr
authors.forename: Paula
authors.initials: P
authors.lastname: Herer
mesh_terms: D015992:Body Mass Index; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000503:physiopathology*; D012890:Sleep; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000503:physiopathology*; D012895:Sleep, REM; D013739:Testosterone / Q000097:blood / Q000378:metabolism*
chemical_list: D013739:Testosterone; D007986:Luteinizing Hormone