title: No evidence for association between polymorphisms in GRM3 and schizophrenia.
abstract: BACKGROUND
  Three studies have previously reported data that were interpreted by the authors as supportive of association between schizophrenia and polymorphisms in the gene encoding the metabotropic glutamate receptor GRM3.
  
  
  METHODS
  In a bid to examine this hypothesis, we examined seven SNPs spanning GRM3 in a UK case-control sample (schizophrenic cases n = 674, controls n = 716). These included all SNPs previously reported to be associated, alone or in haplotypes, with schizophrenia in European or European American samples.
  
  
  RESULTS
  Our data showed no evidence for association with single markers, or 2, 3, 4 and 5 marker haplotypes, nor did any specific haplotypes show evidence for association according to previously observed patterns.
  
  
  CONCLUSIONS
  Examination of our own data and those of other groups leads us to conclude that at present, GRM3 should not be viewed as a gene for which there is replicated evidence for association with schizophrenia.
authors.affiliation: Department of Psychological Medicine, Wales School of Medicine, Henry Wellcome Building, Cardiff University, Heath Park, Cardiff, UK. nortonn@cf.ac.uk <nortonn@cf.ac.uk>
authors.forename: Nadine
authors.initials: N
authors.lastname: Norton
authors.forename: Hywel J
authors.initials: HJ
authors.lastname: Williams
authors.forename: Sarah
authors.initials: S
authors.lastname: Dwyer
authors.forename: Dobril
authors.initials: D
authors.lastname: Ivanov
authors.forename: Anna C
authors.initials: AC
authors.lastname: Preece
authors.forename: Amy
authors.initials: A
authors.lastname: Gerrish
authors.forename: Nigel M
authors.initials: NM
authors.lastname: Williams
authors.forename: Pamela
authors.initials: P
authors.lastname: Yerassimou
authors.forename: Stanley
authors.initials: S
authors.lastname: Zammit
authors.forename: Michael C
authors.initials: MC
authors.lastname: O'Donovan
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Owen
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D005819:Genetic Markers; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate