[Effects of neurotensin on active and passive avoidance performance in rats with lesions of serotoninergic neurons].
After a lesion of serotoninergic neurons performed by administration of 5.7-dihydroxytriptamine into the dorsal raphe nucleus, effects of neurotensin microinjections into the substantia nigra on rat behavior were investigated. Serotoninergic lesions resulted in enhanced fear of rats manifested as an increase in the number of intersignal avoidance reactions and intensification of escape reactions. Neurotensin microinjections into the substantia nigra diminished the neurotoxin action thus increasing the adaptive character of defensive behavior of rats with deficit of functions of serotonin neurons.
Shugalev
I P
IP
Ol'shanskiĭ
A S
AS
Lenard
L
L
Hartmann
G
G
D000818:Animals; D003213:Conditioning, Psychological / Q000187:drug effects; D003342:Corpus Striatum / Q000187:drug effects* / Q000473:pathology*; D004298:Dopamine / Q000378:metabolism; D004924:Escape Reaction / Q000187:drug effects*; D008297:Male; D009496:Neurotensin / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013378:Substantia Nigra / Q000187:drug effects
D012701:Serotonin; D009496:Neurotensin; D004298:Dopamine