title: Utility of C-reactive protein measurement in risk stratification during primary cardiovascular disease prevention.
abstract: High-sensitivity C-reactive protein (hs-CRP) adds prognostic information beyond that provided by the Framingham risk score. The clinical utility of hs-CRP evaluation per guidelines was investigated by determining how it changed the cardiovascular risk stratification of 100 patients deemed at intermediate risk. Screening guidelines defined the cardiovascular risk due to hs-CRP as low (<1.0 mg/L), intermediate (1.0 to 3.0 mg/L), or high (>3.0 mg/L). After hs-CRP evaluation, risk was adjusted in 66% of the patients. Because hs-CRP evaluation significantly altered the cardiovascular risk strata of most intermediate-risk patients, it may therefore be a useful test during primary cardiovascular disease prevention.
authors.affiliation: Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Bard
authors.forename: Melvyn
authors.initials: M
authors.lastname: Rubenfire
authors.forename: Kim
authors.initials: K
authors.lastname: Eagle
authors.forename: Nicholas S
authors.initials: NS
authors.lastname: Clarke
authors.forename: Robert D
authors.initials: RD
authors.lastname: Brook
mesh_terms: D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein