Keep time, stay healthy.
Recent studies reveal that sleep loss in humans leads to metabolic disorders. A new study reports the development of metabolic syndrome in mice with altered circadian timing brought about by a mutation in a gene that functions in the biological clock. An intriguing and unanswered question is the relation between a healthy biological clock and normal appetite and weight regulation.
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Department of Biology, University of Virginia, Charlottesville, VA 22903, USA. gdb@virginia.edu
D000818:Animals; D001066:Appetite; D056926:CLOCK Proteins; D002940:Circadian Rhythm; D005247:Feeding Behavior; D006801:Humans; D020738:Leptin / Q000097:blood; D008322:Mammals / Q000502:physiology; D024821:Metabolic Syndrome / Q000503:physiopathology*; D051379:Mice; D009765:Obesity / Q000503:physiopathology*; D012890:Sleep / Q000502:physiology; D012893:Sleep Wake Disorders / Q000150:complications*; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology; D015430:Weight Gain
D020738:Leptin; D015534:Trans-Activators; D056926:CLOCK Proteins; C538943:CLOCK protein, human; C538944:Clock protein, mouse