Alpha-fetoprotein (AFP)- and des-gamma-carboxy prothrombin (DCP)-producing adenocarcinoma of the stomach with liver metastasis in a patient with chronic hepatitis C.
A 45-year-old man was admitted to our hospital because of chronic hepatitis C and a large liver tumor accompanied by increased serum levels of alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP), the tumor markers for hepatocellular carcinoma. Endoscopic examination revealed advanced gastric cancer. Biopsy specimens of the stomach and liver showed gastric adenocarcinoma and its metastasis to the liver. Immunohistochemical studies demonstrated that adenocarcinoma cells both of the stomach and liver, were positive for the antibodies against AFP as well as DCP. Expression of AFP mRNA was shown in the cancer cells of the stomach. Accordingly, we diagnosed this patient with AFP- and DCP-producing adenocarcinoma of the stomach together with liver metastasis.
Sohda
Tetsuro
T
Third Department of Medicine, Fukuoka University, School of Medicine, Fukuoka.
Tomioka
Yoshitaka
Y
Inomata
Shinjiro
S
Morita
Isamu
I
Eguchi
Koichi
K
Aoyagi
Kunihiko
K
Watanabe
Hiroshi
H
Nakamura
Shotaro
S
Sakisaka
Shotaro
S
D000230:Adenocarcinoma / Q000150:complications / Q000378:metabolism* / Q000556:secondary; D015415:Biomarkers / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood; D001706:Biopsy; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005500:Follow-Up Studies; D005773:Gastroscopy; D015972:Gene Expression Regulation, Neoplastic; D019698:Hepatitis C, Chronic / Q000097:blood / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications / Q000378:metabolism / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D011498:Protein Precursors / Q000097:blood* / Q000235:genetics; D011516:Prothrombin / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D013274:Stomach Neoplasms / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D014057:Tomography, X-Ray Computed; D000509:alpha-Fetoproteins / Q000235:genetics / Q000378:metabolism*
D015415:Biomarkers; D014408:Biomarkers, Tumor; D011498:Protein Precursors; D012333:RNA, Messenger; D000509:alpha-Fetoproteins; C008208:acarboxyprothrombin; D011516:Prothrombin