Immobility in the swim test and observations of maternal behavior in lactating Flinders sensitive line rats.
In order to elucidate the relationship between maternal behavior and depression, the Flinders sensitive line (FSL) model of depression was studied and compared to Sprague-Dawley (SD) controls. Immobility in the swim test was measured, as an index for depressive-like behavior, and frequencies of maternal and non-maternal behaviors were recorded using short un-intrusive observations in the home cage. Lactating FSL rats displayed higher levels of immobility in the swim test compared to controls, indicating depressive-like behavior. In addition, compared to SD rats, FSL dams showed less frequent pup licking and non-nutritive contact with pups during the first and third weeks of lactation. In the third postpartum week, FSL dams showed less frequent nursing postures and more frequent self-directed behaviors. Thus, lactating FSL dams exhibit both depressed-like behavior and some abnormalities in maternal behavior.
Lavi-Avnon
Yael
Y
Department of Psychology, and the Gonda (Goldschmied) Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel.
Shayit
Michal
M
Yadid
Gal
G
Overstreet
H David
HD
Weller
Aron
A
D000704:Analysis of Variance; D000818:Animals; D003863:Depression / Q000235:genetics / Q000503:physiopathology*; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000502:physiology; D005260:Female; D007103:Immobilization; D007774:Lactation / Q000502:physiology*; D008425:Maternal Behavior / Q000502:physiology*; D009043:Motor Activity / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D016192:Resting Phase, Cell Cycle / Q000502:physiology; D013550:Swimming / Q000502:physiology*