Neural representation of response category and motor parameters in monkey prefrontal cortex.
Conditional motor behavior, in which the relationship between stimuli and responses changes arbitrarily, is an important component of cognitive motor function in primates. It is still unclear how cognitive processing for conditional motor control determines movement parameters to directly specify motor output. To address this issue, we studied the neuronal representation of motor variables relating to conditional motor control and also directly to the metrics of motor output in prefrontal cortex (PFC). Monkeys were required to generate a force that fell within one of two categories ("small" and "large"). We found that most PFC neurons were activated as a function of force category, suggesting a role in conditional motor control. At the same time, we found that activity in many PFC neurons varied continuously with the force that was eventually produced, suggesting they participated in specifying the metrics of movements as they were executed. The results suggest that the PFC neural population encodes both "what" motor response should be performed and "how" the selected movement should be realized immediately after the visual instruction.
Fukushi
Tamami
T
Department of Neuroscience, University of Minnesota, Brain Sciences Center (11B) VAMC, One Veterans Drive, Minneapolis, MN, 55455, USA. fukus001@tc.umn.edu
Sawaguchi
Toshiyuki
T
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D003071:Cognition / Q000502:physiology*; D003213:Conditioning, Psychological / Q000502:physiology; D004576:Electromyography; D008253:Macaca mulatta; D008297:Male; D009068:Movement / Q000502:physiology*; D009119:Muscle Contraction / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D010775:Photic Stimulation; D017397:Prefrontal Cortex / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology*