title: Low dose fraction behavior of high sensitivity radiochromic film.
abstract: A high sensitivity (HS) model of radiochromic film is receiving increasing use. The film's linear sensitometric response in the range of 0.5-40 Gy would make this film an ideal candidate for complex dosimetry applications that require tissue equivalence. This study investigates the potential use for clinical dosimetry of typical radiotherapy fractions at relatively low doses (0.5-5 Gy). The experiment involved exposing 25 pre-exposed pieces of HS film to five equal fractions of doses from 0.5 to 5 Gy 24 hours apart. The cumulative dose for each film was carefully monitored and optical density measurements were used as the sole determination of film response to dose. The average behavior of the various fractionation schemes was roughly consistent with previous observations of the MD-55 radiochromic film with about twice the overall sensitivity as expected. However, at low doses and low dose increments, unexpected variations beyond a well-documented low dose nonlinearity were observed. These unexpected variations may indicate complex polymer kinetics at low doses. This type of film would require extra care beyond that described in TG-55 for accurate use at low doses or low dose fraction schemes.
authors.affiliation: University of Wisconsin-Madison, Department of Medical Physics, Madison, Wisconsin 53706, USA.
authors.forename: E Y
authors.initials: EY
authors.lastname: Hirata
authors.forename: C
authors.initials: C
authors.lastname: Cunningham
authors.forename: J A
authors.initials: JA
authors.lastname: Micka
authors.forename: H
authors.initials: H
authors.lastname: Keller
authors.forename: M W
authors.initials: MW
authors.lastname: Kissick
authors.forename: L A
authors.initials: LA
authors.lastname: DeWerd
mesh_terms: D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D005373:Film Dosimetry / Q000379:methods* / Q000592:standards; D007834:Lasers; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods; D011878:Radiotherapy / Q000379:methods; D011879:Radiotherapy Dosage; D020266:Radiotherapy, Conformal / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012984:Software; D013997:Time Factors; D014962:X-Ray Film