title: Does it always help to adjust for misclassification of a binary outcome in logistic regression?
abstract: It is well known that in logistic regression, where the outcome is measured with error, a biased estimate of the association between the outcome and a risk factor may result if no proper adjustment is made. Hence, it seems tempting to always adjust for possible misclassification of the outcome. Here we show that it is not always beneficial to do so because, though the adjustment reduces the bias, it also inflates the variance, leading to a possibly larger mean squared error of the estimate. In the context of a data set on agricultural injuries, numerical evidence is provided through simulation studies.
authors.affiliation: Division of Biostatistics and Epidemiology, The Children's Hospital of Philadelphia, 3535 Market St., 14th Floor, Philadelphia, PA 19104, USA.
authors.forename: Xianqun
authors.initials: X
authors.lastname: Luan
authors.forename: Wei
authors.initials: W
authors.lastname: Pan
authors.forename: Susan G
authors.initials: SG
authors.lastname: Gerberich
authors.forename: Bradley P
authors.initials: BP
authors.lastname: Carlin
mesh_terms: D000062:Accidents, Occupational; D000293:Adolescent; D000328:Adult; D000383:Agriculture; D015982:Bias; D002648:Child; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D008910:Minnesota; D018401:Sample Size