Urinary metabolites of a tobacco-specific lung carcinogen in nonsmoking hospitality workers.
Exposure of nonsmokers to environmental tobacco smoke results in increased risk for cancer and other diseases. In spite of this finding, some restaurants and bars continue to permit smoking. This study examined the uptake of nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a potent lung carcinogen, in nonsmokers who work in restaurants and bars that permitted smoking. Urine samples were collected for 24 hours on working and nonworking days and were analysed for total NNAL [the sum of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronides (NNAL-Glucs)], metabolites of NNK. In addition, urine samples were analysed for total nicotine (nicotine plus nicotine glucuronide), and total cotinine (cotinine plus cotinine-N-glucuronide). The results showed significant increases in urinary levels of total NNAL, total nicotine, and total cotinine on working days compared with nonworking days. The results of this study show that smoke exposure in bars and restaurants may have important health effects on nonsmoking employees, elicited by the increase in carcinogen levels.
Tulunay
Ozlem E
OE
Tobacco Use Research Center, University of Minnesota, 2701 University Avenue Southeast, #201, Minneapolis, MN 55414, USA.
Hecht
Stephen S
SS
Carmella
Steven G
SG
Zhang
Yan
Y
Lemmonds
Charlotte
C
Murphy
Sharon
S
Hatsukami
Dorothy K
DK
D000293:Adolescent; D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects / Q000032:analysis / Q000652:urine*; D015415:Biomarkers / Q000652:urine; D002273:Carcinogens / Q000032:analysis* / Q000378:metabolism; D003367:Cotinine / Q000652:urine; D003404:Creatinine / Q000652:urine; D005260:Female; D005965:Glucuronates / Q000032:analysis / Q000652:urine*; D006801:Humans; D007407:Interviews as Topic; D008175:Lung Neoplasms / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000652:urine; D009602:Nitrosamines / Q000032:analysis / Q000652:urine*; D011725:Pyridines / Q000032:analysis / Q000652:urine*; D012147:Restaurants; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*; D000078329:Workforce
C099564:4-((methylnitrosoamino)-1-(3-pyridyl)but-1-yl)beta-omega-glucosiduronic acid; D000395:Air Pollutants, Occupational; D015415:Biomarkers; D002273:Carcinogens; D005965:Glucuronates; D009602:Nitrosamines; D011725:Pyridines; D014028:Tobacco Smoke Pollution; D009538:Nicotine; C016583:4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; D003404:Creatinine; C099565:4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol; D003367:Cotinine