title: Prepubertal chronic ethanol administration alters TTF-1 and Oct-2 expression in the hypothalamus of female rats.
abstract: We found that prolonged administration of ethanol (3 g/kg i.p. at 08:00, once per day) to young female rats starting on postnatal day 24 caused delayed puberty. We further found that prolonged ethanol administration changed the typical hypothalamic expression patterns of TTF-1 and Oct-2 and reduced GnRH mRNA expression. We suggest that these changes may cause the ethanol-induced disturbances in the regulation of GnRH in the hypothalamus and may be responsible for the ethanol-induced reduction in GnRH and LH associated with delayed puberty.
authors.affiliation: Department of Anatomy and Neurobiology, Institute of Health Sciences, College of Medicinem, Gyeongsang National University, 92 Chilam-dong, Jinju 660-751, South Korea.
authors.forename: Hyun Joon
authors.initials: HJ
authors.lastname: Kim
authors.forename: Hyun Joon
authors.initials: HJ
authors.lastname: Sohn
authors.forename: Myung
authors.initials: M
authors.lastname: Ha
authors.forename: Jae Yoon
authors.initials: JY
authors.lastname: Han
authors.forename: Sang Soo
authors.initials: SS
authors.lastname: Kang
authors.forename: Wan Sung
authors.initials: WS
authors.lastname: Choi
authors.forename: Gyeong Jae
authors.initials: GJ
authors.lastname: Cho
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D000831:Animals, Newborn; D015153:Blotting, Western; D002452:Cell Count / Q000379:methods; D002492:Central Nervous System Depressants / Q000008:administration & dosage*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004334:Drug Administration Schedule; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D007150:Immunohistochemistry; D009687:Nuclear Proteins / Q000378:metabolism*; D050813:Octamer Transcription Factor-2; D051381:Rats; D017207:Rats, Sprague-Dawley; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D002492:Central Nervous System Depressants; D004268:DNA-Binding Proteins; C000614416:Nkx2-1 protein, rat; D009687:Nuclear Proteins; D050813:Octamer Transcription Factor-2; C489205:Pou2f2 protein, rat; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors; D007987:Gonadotropin-Releasing Hormone; D000431:Ethanol