title: The use of oscillatory signals in the study of genetic networks.
abstract: The structure of a genetic network is uncovered by studying its response to external stimuli (input signals). We present a theory of propagation of an input signal through a linear stochastic genetic network. We found that there are important advantages in using oscillatory signals over step or impulse signals and that the system may enter into a pure fluctuation resonance for a specific input frequency.
authors.affiliation: Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, CA-4124, Augusta, GA 30912, USA. olipan@mail.mcg.edu
authors.forename: Ovidiu
authors.initials: O
authors.lastname: Lipan
authors.forename: Wing H
authors.initials: WH
authors.lastname: Wong
mesh_terms: D005786:Gene Expression Regulation; D016014:Linear Models; D008957:Models, Genetic; D008967:Molecular Biology / Q000379:methods*; D011401:Promoter Regions, Genetic / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism*; D013269:Stochastic Processes; D049490:Systems Biology / Q000379:methods*; D013997:Time Factors
chemical_list: D012333:RNA, Messenger