Evaluation of commercial assay detecting specific immunoglobulin g in oral fluid for determining measles immunity in vaccinees.
A commercial assay for detection of measles immunoglobulin G (IgG) in oral fluid was evaluated in a highly vaccinated cohort using serum IgG as gold standard. In contrast to previous studies from cohorts protected by natural immunity, antibody prevalence was significantly underestimated (-7.4%; confidence interval: -1.5 to -13.2%; P = 0.01) due to a reduced sensitivity when antibody levels were low.
Kremer
Jacques R
JR
Institute of Immunology, WHO Collaborative Centre for Measles, WHO European Regional Reference Laboratory for Measles and Rubella, Laboratoire National de Santé, L-1011 Luxembourg.
Muller
Claude P
CP
D000914:Antibodies, Viral / Q000032:analysis*; D000917:Antibody Formation / Q000187:drug effects; D015331:Cohort Studies; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008457:Measles / Q000628:therapy*; D008458:Measles Vaccine / Q000494:pharmacology*; D011933:Reagent Kits, Diagnostic / Q000592:standards*; D012463:Saliva / Q000276:immunology; D012680:Sensitivity and Specificity
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D008458:Measles Vaccine; D011933:Reagent Kits, Diagnostic