Suppression of conditioned nicotine and sucrose seeking by the cannabinoid-1 receptor antagonist SR141716A.
The present study shows that the selective cannabinoid CB1 receptor antagonist SR141716A attenuated responding for both nicotine- and sucrose-associated stimuli in a long-term extinction-reinstatement model. The results suggest that endocannabinoids play a general role in modulating cue reactivity or conditioned reinforcement following prolonged abstinence of both drug and natural reinforcers. In line with previous preclinical and recent clinical observations, our results provide a strong rationale for the use of CB1 antagonists in the treatment of addictive behaviors.
De Vries
Taco J
TJ
Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research, Department of Medical Pharmacology, VU Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands. tj.devries@vumc.nl
de Vries
Wendy
W
Janssen
Mieke C W
MC
Schoffelmeer
Anton N M
AN
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D063387:Cannabinoid Receptor Antagonists; D003216:Conditioning, Operant / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005108:Extinction, Psychological / Q000187:drug effects; D007266:Inhibition, Psychological; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D000077285:Rimonabant; D013395:Sucrose / Q000494:pharmacology*; D013549:Sweetening Agents
D063387:Cannabinoid Receptor Antagonists; D018722:Nicotinic Agonists; D010880:Piperidines; D011720:Pyrazoles; D013549:Sweetening Agents; D013395:Sucrose; D009538:Nicotine; D000077285:Rimonabant