title: [Clinical example of recovery from psychosis in the context of the theory of psychosis as a state of aberrant salience].
abstract: According to the theory proposed by S. Kapur psychosis is a state of aberrant salience. Dopamine and mesolimbic system play the key role in the occurrence of psychosis. According to Kapur dopamine mediates the conversion of neural representations of an external stimulus from a neutral into attractive or aversive. In the psychosis this physiological role of the dopamine is changed. Dopamine starts to create a process of salience acquisition; instead of mediate it as it is in normal circumstances. According to Kapur delusions are cognitive explanations that the individual imposes on the experience of aberrant salience. Pharmacological agents share the psychological effect-dampening salience. But antipsychotics only provide the state of attenuated salience and symptomatic improvement needs further psychological and cognitive resolution. The case of a patient with paranoid psychosis during treatment with risperidone was analyzed in the context of Kapur's theory. Reports of experiences given by patients can support the theory and make it valuable in the conceptualization of the process of step-by-step recovery from psychosis.
authors.affiliation: III Klinika Psychiatryczna AM w Warszawie.
authors.forename: Sławomir
authors.initials: S
authors.lastname: Murawiec
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D004298:Dopamine / Q000378:metabolism*; D018492:Dopamine Antagonists / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D009042:Motivation; D010349:Patient Compliance; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000378:metabolism* / Q000523:psychology; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism; D018967:Risperidone / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D014150:Antipsychotic Agents; D018492:Dopamine Antagonists; D011954:Receptors, Dopamine; D018967:Risperidone; D004298:Dopamine