title: Pseudolaminar necrosis in cyanide intoxication: a neuropathology case report.
abstract: We describe the gross and microscopic neuropathological changes in the brain of a 17-year-old male who died 4 days after being poisoned with cyanide. Previous reports indicate that following cyanide intoxication, the brain develops diffuse hypoxic/ischemic changes, predominantly of the basal ganglia. The case we describe here had similar features but in addition showed striking laminar necrosis of the cerebral cortex. This finding in cyanide poisoning has been previously demonstrated by neuroimaging, but not pathologically.
authors.affiliation: Department of Pathology (Neuropathology), Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Riudavets
authors.forename: Patricia
authors.initials: P
authors.lastname: Aronica-Pollak
authors.forename: Juan C
authors.initials: JC
authors.lastname: Troncoso
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D017209:Apoptosis; D001628:Beverages / Q000032:analysis; D001921:Brain / Q000473:pathology*; D003128:Coma / Q000139:chemically induced*; D003485:Cyanates / Q000097:blood / Q000737:chemistry / Q000506:poisoning*; D049429:Forensic Pathology; D006323:Heart Arrest / Q000139:chemically induced*; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000473:pathology; D008297:Male; D009336:Necrosis; D009474:Neurons / Q000473:pathology
chemical_list: D003485:Cyanates; C024835:potassium cyanate