title: Investigation of using a power function as a cost function in inverse planning optimization.
abstract: The purpose of this paper is to investigate the use of a power function as a cost function in inverse planning optimization. The cost function for each structure is implemented as an exponential power function of the deviation between the resultant dose and prescribed or constrained dose. The total cost function for all structures is a summation of the cost function of every structure. When the exponents of all terms in the cost function are set to 2, the cost function becomes a classical quadratic cost function. An independent optimization module was developed and interfaced with a research treatment planning system from the University of North Carolina for dose calculation and display of results. Three clinical cases were tested for this study with various exponents set for tumor targets and sensitive structures. Treatment plans with these exponent settings were compared, using dose volume histograms. The results of our study demonstrated that using an exponent higher than 2 in the cost function for the target achieved better dose homogeneity than using an exponent of 2. An exponent higher than 2 for serial sensitive structures can effectively reduce the maximum dose. Varying the exponent from 2 to 4 resulted in the most effective changes in dose volume histograms while the change from 4 to 8 is less drastic, indicating a situation of saturation. In conclusion, using a power function with exponent greater than 2 as a cost function can effectively achieve homogeneous dose inside the target and/or minimize maximum dose to the critical structures.
authors.affiliation: Department of Radiation Oncology, University of California-San Francisco, San Francisco, California 94143-1708, USA.
authors.forename: Ping
authors.initials: P
authors.lastname: Xia
authors.forename: Naichang
authors.initials: N
authors.lastname: Yu
authors.forename: Lei
authors.initials: L
authors.lastname: Xing
authors.forename: Xuepeng
authors.initials: X
authors.lastname: Sun
authors.forename: Lynn J
authors.initials: LJ
authors.lastname: Verhey
mesh_terms: D000465:Algorithms; D001921:Brain / Q000473:pathology; D004307:Dose-Response Relationship, Radiation; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000532:radiotherapy; D006801:Humans; D008527:Medulloblastoma / Q000532:radiotherapy; D015233:Models, Statistical; D011874:Radiometry / Q000379:methods; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods*; D012008:Recurrence