title: Association between polymorphisms of the GPX1 gene and second primary tumours after index squamous cell cancer of the head and neck.
abstract: We investigated the association between genetic polymorphisms in GPX1 gene amongst patients who had index squamous cell carcinoma (SCCHN) and a second primary tumour (SPT) after a primary SCCHN in a case-control study. GPX1 genotypes were determined for 61 patients with SPT and for 259 control subjects by a PCR technique using a fluorescent-labelled primer. Analysis was by an ABI automated fluorescent sequencer. The associations between specific genotypes and the development of SPT were examined by logistic regression. A significant difference was found between the control group and the SPT cases in allele frequencies of GPX1 ALA( *)6 and ALA( *)7 (p(trend)=0.04). These results suggest that polymorphisms in the GPX1 gene may be a marker for SPT development and further studies are indicated.
authors.affiliation: Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.
authors.forename: S
authors.initials: S
authors.lastname: Jefferies
authors.forename: Z
authors.initials: Z
authors.lastname: Kote-Jarai
authors.forename: D
authors.initials: D
authors.lastname: Goldgar
authors.forename: R
authors.initials: R
authors.lastname: Houlston
authors.forename: M-J
authors.initials: MJ
authors.lastname: Frazer-Williams
authors.forename: R
authors.initials: R
authors.lastname: A'Hern
authors.forename: R
authors.initials: R
authors.lastname: Eeles
authors.forename: J
authors.initials: J
authors.lastname: Henk
authors.forename: M
authors.initials: M
authors.lastname: Gore
authors.forename: P
authors.initials: P
authors.lastname: Rhys-Evans
authors.forename: D
authors.initials: D
authors.lastname: Archer
authors.forename: K
authors.initials: K
authors.lastname: Bishop
authors.forename: E
authors.initials: E
authors.lastname: Solomon
authors.forename: S
authors.initials: S
authors.lastname: Hodgson
authors.forename: M
authors.initials: M
authors.lastname: McGurk
authors.forename: J
authors.initials: J
authors.lastname: Hibbert
authors.forename: M
authors.initials: M
authors.lastname: O'Connell
authors.forename: M
authors.initials: M
authors.lastname: Partridge
authors.forename: E
authors.initials: E
authors.lastname: Chevretton
authors.forename: F
authors.initials: F
authors.lastname: Calman
authors.forename: M
authors.initials: M
authors.lastname: Saunders
authors.forename: K
authors.initials: K
authors.lastname: Shotton
authors.forename: A
authors.initials: A
authors.lastname: Brown
authors.forename: S
authors.initials: S
authors.lastname: Whittaker
authors.forename: W
authors.initials: W
authors.lastname: Foulkes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005979:Glutathione Peroxidase / Q000235:genetics*; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000235:genetics*; D018307:Neoplasms, Squamous Cell / Q000235:genetics*; D016017:Odds Ratio; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D000094765:Glutathione Peroxidase GPX1
chemical_list: D005979:Glutathione Peroxidase; D000094765:Glutathione Peroxidase GPX1; C000722067:GPX1 protein, human