An experimental study of apico-aortic valved conduit (AAVC) for surgical treatment of aortic stenosis in dogs.
A new valved conduit was developed using a canine aortic valve. The bioprosthetic valve was fixed with glutaraldehyde and epoxy compound (Denacol-EX313/810). A vascular graft composed of ultra-fine polyester fiber (10 mm in diameter, 200 mm in length) was used. Four dogs underwent apico-aortic valved conduit (AAVC) implantation and aortic banding (bypass group, BG), while another 4 dogs underwent aortic banding without AAVC implantation (control group, CG). Cardiac catheterization and angiocardiography were performed for assessment of hemodynamics 2 weeks and 6 months after surgery. Left ventricular systolic pressure, left ventricular end-diastolic pressure and the left ventricular-aortic pressure gradient differed significantly (P<0.01) between the BG and CG dogs. Left ventricular angiocardiography showed patency of the valved conduit in all the BG dogs. Echocardiography was performed before and 2, 4 and 6 months after surgery, and showed that while pressure overload caused concentric myocardial hypertrophy in the CG dogs, the left ventricle dilated eccentrically in the BG dogs. Furthermore, relief of left ventricular pressure overload by AAVC was maintained.
Hirao
Hidehiro
H
Department of Veterinary Surgery, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Japan.
Inoue
Tomoki
T
Hoshi
Katsuichiro
K
Kobayashi
Masayuki
M
Shimamura
Shunsuke
S
Shimizu
Miki
M
Tanaka
Ryou
R
Takashima
Kazuaki
K
Mori
Yuichi
Y
Noishiki
Yasuharu
Y
Yamane
Yoshihisa
Y
D000790:Angiocardiography / Q000662:veterinary; D000818:Animals; D001024:Aortic Valve Stenosis / Q000601:surgery / Q000662:veterinary*; D001705:Bioprosthesis / Q000662:veterinary*; D001794:Blood Pressure; D001807:Blood Vessel Prosthesis / Q000662:veterinary*; D006328:Cardiac Catheterization / Q000662:veterinary; D004283:Dog Diseases / Q000601:surgery*; D004285:Dogs; D004452:Echocardiography / Q000662:veterinary; D004853:Epoxy Resins; D005976:Glutaral; D011091:Polyesters; D011126:Polypropylenes; D011479:Protamines
D004853:Epoxy Resins; D011091:Polyesters; D011126:Polypropylenes; D011479:Protamines; C050906:polyglycerol polyglycidyl ether; C035364:Quetol 651; D005976:Glutaral