Cell therapies in neuro-oncology.
During their growth, malignant gliomas interact with the immune system and are able to escape immune reactions. Attempts to instruct the immune system to develop anti-glioma reactions have been partly unsuccessful. Recent advances in the molecular and cellular biology of dendritic cells (DC), however, may increase the chances of preparing effective "vaccines" against these tumours. We show that vaccination with DC pulsed with a tumour lysate considerably increases survival in mice bearing intracranial glioblastomas. These results support the development of DC-based clinical trials for patients with glioblastomas that do not respond to standard therapies.
Pellegatta
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Istituto Nazionale Neurologico Carlo Besta, Unit of Experimental Neuro-Oncology, Via Celoria 11, I-20133 Milan, Italy.
Finocchiaro
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D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D001932:Brain Neoplasms / Q000276:immunology / Q000628:therapy*; D019496:Cancer Vaccines / Q000627:therapeutic use; D002452:Cell Count; D017690:Cell Transplantation / Q000379:methods; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000502:physiology* / Q000637:transplantation; D005910:Glioma / Q000276:immunology / Q000628:therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D013997:Time Factors
D015703:Antigens, CD; D019496:Cancer Vaccines