[Effect of shenmai injection on immunologic function in patients with dilated cardiomyopathy].
OBJECTIVE
To investigate the effect of Shenmai Injection (SMI) on immunologic function in patients with dilated cardiomyopathy (DCM).


METHODS
Fifty-six patients were divided into two groups, the control group treated with conventional western medicine, and the SMI group treated with conventional western medicine plus SMI. The indices including red blood cell (RBC) C3b receptor rosette (RBC-C3bRR) and immune complex rosette (RBC-ICR), T-lymphocyte subsets (CD3, CD4, CD8, CD4/CD8) were determined before and after treatment.


RESULTS
The level of RBC-C3bRR, CD4, CD8 and CD3 in patients with DCM were significantly decreased (P <0 .01, P < 0.05), RBC-ICR and CD4/CD8 were significantly increased than those in the normal control group (P < 0.01); While the level of RBC-C3bRR, CD4, CD8 and CD3 in the SMI group after treatment were significantly higher, and the level of RBC-ICR and CD4/CD8 were significantly lower (P < 0.01, P < 0.05) than those in the control group.


CONCLUSIONS
The RBC immune adherence and cellular immune function are lower in patients with DCM, and SMI has the effect in regulating immune function in patients with DCM.
Ma
Bin
B
Department of Cardiology, The Second Hospital of Xi'an Jiaotong University, Xi'an. mabin1965@163.com
Niu
Xiao-Lin
XL
Wang
Ming-Xia
MX
D002311:Cardiomyopathy, Dilated / Q000188:drug therapy* / Q000276:immunology*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007104:Immune Adherence Reaction; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D017463:Receptors, Complement 3b / Q000097:blood; D012397:Rosette Formation; D016176:T-Lymphocyte Subsets / Q000276:immunology
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D017463:Receptors, Complement 3b; C009252:fructus schizandrae, radix ginseng, radix ophiopogonis drug combination