title: Spinal epithelioid hemangioendothelioma with epithelioid angiosarcomatous areas.
abstract: Epithelioid hemangioendothelioma is a distinctive vascular tumor rarely involving bones. We report a case of epithelioid hemangioendothelioma in the cervical spine with angiosarcomatous areas. A 50-year-old female presented with dizziness while walking. A mixed sclerotic and osteolytic or destructive lesion was radiographically disclosed in her upper cervical vertebrae. Histologically, a laminectomy specimen exhibited areas of ordinary epithelioid hemangioendothelioma together with foci of more atypical epithelioid cell proliferation, closely resembling epithelioid angiosarcoma. This phenomenon has been exceptionally described in cases with skeletal lesions, which are typically of low-grade malignancy.
authors.affiliation: Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Hisaoka
authors.forename: Sumika
authors.initials: S
authors.lastname: Okamoto
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Aoki
authors.forename: Koichiro
authors.initials: K
authors.lastname: Yokoyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hashimoto
mesh_terms: D001706:Biopsy; D002574:Cervical Vertebrae / Q000473:pathology*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D018323:Hemangioendothelioma, Epithelioid / Q000175:diagnosis* / Q000556:secondary; D006394:Hemangiosarcoma / Q000175:diagnosis* / Q000556:secondary; D006801:Humans; D008875:Middle Aged; D013125:Spinal Neoplasms / Q000175:diagnosis* / Q000556:secondary