[Is stress-induced analgesia a measure of stress severity?].
When comparing magnitudes of "behavioural despair" (duration of immobility) and stress-induced analgesia in the tail suspension test and cold water swim test with SHR and NMRI male mice. The results might depend on saline injection prior the test and on the fact that exposure to cold water in swim test was sufficient to alter the response patterns. The findings show that the main parameters are closely related to each other. Stress-induced analgesia seems to be a measure of stress as the stress becomes stronger analgesia changes in linear dependence, whereas duration of immobility has an invert U-shaped function.
Kenunen
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Prakh'e
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D000818:Animals; D003080:Cold Temperature; D007103:Immobilization / Q000379:methods; D008297:Male; D051379:Mice; D010146:Pain / Q000209:etiology / Q000523:psychology*; D010433:Pentylenetetrazole / Q000494:pharmacology; D012720:Severity of Illness Index; D013045:Species Specificity; D013315:Stress, Psychological / Q000209:etiology / Q000523:psychology*; D013550:Swimming
D010433:Pentylenetetrazole