Pseudolaminar necrosis in cyanide intoxication: a neuropathology case report.
We describe the gross and microscopic neuropathological changes in the brain of a 17-year-old male who died 4 days after being poisoned with cyanide. Previous reports indicate that following cyanide intoxication, the brain develops diffuse hypoxic/ischemic changes, predominantly of the basal ganglia. The case we describe here had similar features but in addition showed striking laminar necrosis of the cerebral cortex. This finding in cyanide poisoning has been previously demonstrated by neuroimaging, but not pathologically.
Riudavets
Miguel Angel
MA
Department of Pathology (Neuropathology), Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
Aronica-Pollak
Patricia
P
Troncoso
Juan C
JC
D000284:Administration, Oral; D000293:Adolescent; D017209:Apoptosis; D001628:Beverages / Q000032:analysis; D001921:Brain / Q000473:pathology*; D003128:Coma / Q000139:chemically induced*; D003485:Cyanates / Q000097:blood / Q000737:chemistry / Q000506:poisoning*; D049429:Forensic Pathology; D006323:Heart Arrest / Q000139:chemically induced*; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000473:pathology; D008297:Male; D009336:Necrosis; D009474:Neurons / Q000473:pathology
D003485:Cyanates; C024835:potassium cyanate