title: Correlation between apoptotic endothelial microparticles and serum interleukin-6 and C-reactive protein in healthy men.
abstract: Inflammation has been associated with increased cardiovascular risk, and endothelial cell (EC) apoptosis has been implicated in atherogenesis. The correlation between circulating concentrations of interleukin-6 (IL-6), C-reactive protein (CRP), and endothelial microparticles (EMPs) expressing an apoptotic (EMP31) or activation (EMP62E) phenotype in 20 middle-aged healthy men was investigated. IL-6 was significantly correlated with EMP31 (r = 0.6, p = 0.004), which persisted after adjusting for body mass index and CRP. CRP was significantly correlated with body mass index (r = 0.49, p = 0.02) but not with EMP31 or EMP62E. EC apoptosis is associated with IL-6 levels in men and might be partially responsible for the increased cardiovascular risk associated with subclinical inflammation.
authors.affiliation: Department of Medicine, Wallace H. Coulter Platelet Laboratory, University of Miami, Miami, Florida 33136, USA. jchirinos@med.miami.edu <jchirinos@med.miami.edu>
authors.forename: Julio A
authors.initials: JA
authors.lastname: Chirinos
authors.forename: Juan P
authors.initials: JP
authors.lastname: Zambrano
authors.forename: Salim S
authors.initials: SS
authors.lastname: Virani
authors.forename: Joaquin J
authors.initials: JJ
authors.lastname: Jimenez
authors.forename: Wenche
authors.initials: W
authors.lastname: Jy
authors.forename: Eugene
authors.initials: E
authors.lastname: Ahn
authors.forename: Lawrence L
authors.initials: LL
authors.lastname: Horstman
authors.forename: Agustin
authors.initials: A
authors.lastname: Castellanos
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Myerburg
authors.forename: Yeon S
authors.initials: YS
authors.lastname: Ahn
mesh_terms: D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012016:Reference Values
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules; D015850:Interleukin-6; D002097:C-Reactive Protein