Allophylus serratus: a plant with potential anti-ulcerogenic activity.
Allophylus serratus is known to possess various therapeutic properties. We evaluated the anti-ulcerogenic property of crude ethanolic extract of Allophylus serratus (AS) in different ulcer models in Sprague-Dawley rats. The extract at 400 mg/kg body weight, once daily, orally has a significant effect in cold restraint (CRU, 2 h cold restraint stress), aspirin (ASA, 150 mg/kg body weight, orally), alcohol (AL, 1 ml/200 gm of absolute alcohol) and pyloric ligation (PL, 4h ligation) induced gastric ulcer models as it showed protection index of 71.28, 62.50, 90.84 and 64.29% protection, respectively whereas, standard drug omeprazole (OMZ, 10mg/kg body weight) has shown protection index of 85.70, 74.99 and 74.99 in CRU, ASA and PL model respectively. Sucralfate (SUC, 500 mg/kg body weight) as a standard drug in AL model has 93.20% protection. Furthermore, AS has significantly decreased the free acidity (72.41%), total acidity (47.97%) and peptic activity (24.59%), respectively as well as has significantly increased the mucus secretion (29.41%). Conclusively the ulcer protective effect of AS may be due to its anti-secretory along with cytoprotective mechanism.
Dharmani
Poonam
P
Department of Pharmacology, Central Drug Research Institute, P.B. No. 173, Lucknow, Uttar Pradesh 226001, India.
Mishra
Pushpesh Kumar
PK
Maurya
Rakesh
R
Singh Chauhan
Vinay
V
Palit
Gautam
G
D000284:Administration, Oral; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D001241:Aspirin / Q000633:toxicity; D003080:Cold Temperature / Q000009:adverse effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000737:chemistry / Q000633:toxicity; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D009093:Mucus / Q000378:metabolism; D009853:Omeprazole / Q000008:administration & dosage / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D029631:Sapindaceae / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control
D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D012997:Solvents; D000431:Ethanol; D009853:Omeprazole; D001241:Aspirin