title: [Clinical expression of precocious pubertal development in girls].
abstract: The paediatric endocrinologist is frequently asked whether pubertal development in a girl is normal, early or too early (precocious). This review will cover all clinical expression of premature development of puberty: central precocious puberty (neurogenic, secondary, and idiopathic) where treatment with GnRHa is considered, early puberty, partial puberty or pubertal variants and peripheral or pseudo precocious puberty related to an antonomous hypersecretion of estrogens by the ovaries. A special attention should be paid also to the role of environmental disruptors in the development of peripheral precocious puberty. GnRHa treatment should be considered only when evidence of central activation of the gonadotropic axis is proved by the LHRH-test.
authors.affiliation: Unité d'endocrinologie-gynécologie pédiatriques, service de pédiatrie-I, hôpital Arnaud-de-Villeneuve, CHU de Montpellier, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 05, France. c-sultan@chu-montpellier.fr
authors.forename: C
authors.initials: C
authors.lastname: Sultan
authors.forename: F
authors.initials: F
authors.lastname: Paris
authors.forename: C
authors.initials: C
authors.lastname: Jeandel
authors.forename: S
authors.initials: S
authors.lastname: Lumbroso
authors.forename: A
authors.initials: A
authors.lastname: Ecochard
authors.forename: N
authors.initials: N
authors.lastname: Kalfa
mesh_terms: D002648:Child; D004700:Endocrine System Diseases / Q000150:complications; D004777:Environment; D004967:Estrogens / Q000378:metabolism; D005260:Female; D005359:Fibrous Dysplasia, Polyostotic / Q000150:complications; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists / Q000627:therapeutic use; D006801:Humans; D010053:Ovary / Q000378:metabolism; D011627:Puberty; D011629:Puberty, Precocious / Q000175:diagnosis* / Q000209:etiology
chemical_list: D004967:Estrogens; D007987:Gonadotropin-Releasing Hormone