title: Sox group E gene expression distinguishes different types and maturational stages of glial cells in developing chick and mouse.
abstract: The SoxE genes, Sox8, Sox9 and Sox10, have been shown to modulate glial specification and differentiation in the peripheral nervous system and spinal cord. However, little is known of their expression during brain development. We have therefore analyzed their expression in developing brain, focused on the cerebellum. In situ hybridization showed a striking degree of temporo-spatial variation in their expression in different glial lineages in both chick and mouse. Sox8 appeared both in oligodendrocytes and astrocytes, Sox9 was more abundant in astrocytes and Sox10 was restricted to later stages of oligodendrocyte development.
authors.affiliation: Department of Pediatric Hematology and Oncology, University Hospital Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Kordes
authors.forename: Yi-Chuan
authors.initials: YC
authors.lastname: Cheng
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Scotting
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000378:metabolism; D051792:Basic Helix-Loop-Helix Proteins; D002454:Cell Differentiation / Q000502:physiology*; D019070:Cell Lineage / Q000502:physiology; D002531:Cerebellum / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D002642:Chick Embryo; D004268:DNA-Binding Proteins / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D006609:High Mobility Group Proteins / Q000235:genetics; D051379:Mice; D009363:Neoplasm Proteins / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics; D009457:Neuroglia / Q000166:cytology / Q000378:metabolism*; D000076104:Oligodendrocyte Transcription Factor 2; D009836:Oligodendroglia / Q000166:cytology / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D055758:SOX9 Transcription Factor; D055757:SOXE Transcription Factors; D013045:Species Specificity; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*; D013997:Time Factors; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D006609:High Mobility Group Proteins; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D000076104:Oligodendrocyte Transcription Factor 2; D012333:RNA, Messenger; D055758:SOX9 Transcription Factor; D055757:SOXE Transcription Factors; D014157:Transcription Factors; C494786:Olig1 protein, mouse; C512773:Olig2 protein, mouse; C527924:Sox10 protein, mouse; C498639:Sox8 protein, mouse; C527933:Sox9 protein, mouse