title: Cardiac troponin I predicts outcome after ruptured abdominal aortic aneurysm repair.
abstract: BACKGROUND
  Cardiac troponin I (cTnI) is a highly sensitive and specific marker for myocardial injury that predicts mortality in patients with acute coronary syndromes. This study examined the relationship between perioperative cTnI levels and clinical outcome in patients with ruptured abdominal aortic aneurysm (AAA).
  
  
  METHODS
  Consecutive patients who underwent operative repair of a ruptured AAA over a 22-month interval and survived for more than 24 h were entered into a prospective observational cohort study. Levels of cTnI were measured immediately before, and at 24 and 48 h after surgery, and related to clinical outcome.
  
  
  RESULTS
  Of 62 patients who underwent attempted operative repair of ruptured AAA, 50 (81 per cent) survived for more than 24 h and were included in this study. Twenty-three (46 per cent) of the 50 had a detectable cTnI level at one or more time points during the first 48 h. Of these, 11 patients had clinical or electrocardiographic evidence of an acute cardiac event and 12 did not; five patients in each of these two groups died. Of 27 patients with no increase in cTnI in the first 48 h, only three died (P = 0.031 and P = 0.043 respectively, relative to the groups with detectable cTnI).
  
  
  CONCLUSIONS
  Approximately half of patients who survived repair of ruptured AAA for more than 24 h sustained a detectable myocardial injury within the first 48 h. A perioperative increase in the level of cTnI, with or without clinically apparent cardiac dysfunction, was associated with postoperative death.
authors.affiliation: Edinburgh Vascular Surgical Service, Clinical and Surgical Sciences (Surgery), University of Edinburgh, UK. andrew.tambyraja@ed.ac.uk
authors.forename: A L
authors.initials: AL
authors.lastname: Tambyraja
authors.forename: A R W
authors.initials: AR
authors.lastname: Dawson
authors.forename: J A
authors.initials: JA
authors.lastname: Murie
authors.forename: R T A
authors.initials: RT
authors.lastname: Chalmers
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000097:blood* / Q000601:surgery; D001019:Aortic Rupture / Q000097:blood* / Q000601:surgery; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D016896:Treatment Outcome; D019210:Troponin I / Q000097:blood*
chemical_list: D019210:Troponin I