STAT4: a critical regulator of inflammation in vivo.
Signal transducer and activator of transcription 4 (STAT4) is a central mediator in generating inflammation during protective immune responses and immune-mediated diseases. In the 8 yr since their first description, STAT4-deficient mice have defined the role of STAT4 in a variety of in vivo model systems. Despite the extensive study and use of these mice, the exact role of STAT4 in vivo is still unclear. In this review, I focus on describing the phenotypes of STAT4-deficient immune responses to pathogens and in diseases. Comparing the effects of STAT4 deficiency among numerous model systems will further enhance the development of a systemic model of STAT4 function in vivo.
Kaplan
Mark H
MH
Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, 950 West Walnut Street, Indianapolis, IN 46202, USA. mkaplan2@iupui.edu
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D001424:Bacterial Infections / Q000276:immunology; D016207:Cytokines / Q000096:biosynthesis; D006410:Hematopoiesis; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006967:Hypersensitivity / Q000276:immunology; D007108:Immune Tolerance; D007249:Inflammation / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D009369:Neoplasms / Q000276:immunology; D010272:Parasitic Diseases / Q000276:immunology; D050797:STAT4 Transcription Factor / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction; D014181:Transplantation Immunology; D014777:Virus Diseases / Q000276:immunology
D016207:Cytokines; D000949:Histocompatibility Antigens Class II; D050797:STAT4 Transcription Factor