title: Altering metabolism.
abstract: A significant proportion of the mortality and morbidity of severe burns is attributable to the ensuing hypermetabolic response. This response can last for as long as 1 year after injury and is associated with impaired wound healing, increased infection risks, erosion of lean body mass, hampered rehabilitation, and delayed reintegration of burn survivors into society. Pharmacologic and nonpharmacologic strategies may be used to reverse the catabolic effect of thermal injury. Nonpharmacologic strategies include early excision and wound closure of burn wound, aggressive treatment of sepsis, elevation of the environmental temperature to thermal neutrality (31.5 +/- 0.7 degrees C), high carbohydrate, high protein continuous enteral feeding, and early institution of resistive exercise programs. Pharmacologic modulators of the postburn hypermetabolic response may be achieved through the administration of recombinant human growth hormone, low-dose insulin infusion, use of the synthetic testosterone analog, oxandrolone, and beta blockade with propranolol. This review article discusses these modulators of postburn metabolism.
authors.affiliation: Shriners Hospitals for Children, Galveston, Texas 77550, USA.
authors.forename: Clifford T
authors.initials: CT
authors.lastname: Pereira
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Murphy
authors.forename: David N
authors.initials: DN
authors.lastname: Herndon
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D045930:Anabolic Agents / Q000627:therapeutic use; D001833:Body Temperature Regulation; D002056:Burns / Q000378:metabolism* / Q000628:therapy*; D002395:Catecholamines / Q000037:antagonists & inhibitors; D015444:Exercise; D019382:Human Growth Hormone / Q000627:therapeutic use; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D007334:Insulin-Like Growth Factor I / Q000627:therapeutic use; D018529:Nutritional Support; D010074:Oxandrolone / Q000627:therapeutic use; D018805:Sepsis / Q000517:prevention & control; D013696:Temperature; D014945:Wound Healing
chemical_list: D000319:Adrenergic beta-Antagonists; D045930:Anabolic Agents; D002395:Catecholamines; D007004:Hypoglycemic Agents; D007328:Insulin; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D010074:Oxandrolone