Single-cell transcriptional profiles and spatial patterning of the mammalian olfactory epithelium.
In order to gain insights into the regulatory control of neuronal diversity in the mammalian olfactory system, we have identified the transcriptional profile of individual olfactory neurons. A single cell microarray strategy was performed to search for candidate genes involved in the molecular specification of dorso-ventral zones of olfactory receptor (OR) expression. Several transcripts were identified that display differential expression in distinct OR zones, including a novel family of genes, the Lozenge-like (Lzl) genes which share sequence consensus motifs with Lozenge, a transcription factor involved in the patterning of the Drosophila olfactory and visual systems.
Tietjen
Ian
I
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA, USA.
Rihel
Jason
J
Dulac
Catherine G
CG
D000595:Amino Acid Sequence; D000818:Animals; D019521:Body Patterning / Q000235:genetics / Q000502:physiology*; D017124:Conserved Sequence; D017931:DNA Primers; D004847:Epithelial Cells / Q000166:cytology / Q000502:physiology; D020869:Gene Expression Profiling; D051379:Mice; D008969:Molecular Sequence Data; D009420:Nervous System / Q000196:embryology; D018034:Olfactory Receptor Neurons / Q000166:cytology / Q000502:physiology*; D016133:Polymerase Chain Reaction; D014157:Transcription Factors / Q000235:genetics; D014158:Transcription, Genetic
D017931:DNA Primers; D014157:Transcription Factors