[Pathophysiology of infection on orthopedic biomaterials].
Orthopedic biomaterials are foreign bodies and the molecular architecture of their surfaces provides a point of attachment for bacteria. This adherence is made possible through the interaction of the protein interface and the bacterial adhesins. Bacterial colonies use slime and biofilm as means of protection. The development of bacteria towards a reversible state of stationary growth or microcolony variants permits their survival. Microparticles released by biomaterials cause the chronic inflammation associated with the aseptic loosening of prostheses. Some bacterial sub-populations develop transitory resistance to bactericidal antibiotics in the presence of these materials.
Ader
Florence
F
Département de médecine aiguë spécialisée, Hôpital Raymond-Poincaré (AP-HP), Université de Versailles Saint Quentin-en-Yvelines 104, Boulevard Raymond Poincaré, 92380 Garches.
Bernard
Louis
L
D001424:Bacterial Infections / Q000209:etiology*; D001672:Biocompatible Materials / Q000009:adverse effects*; D018441:Biofilms / Q000254:growth & development; D006801:Humans; D049329:Nanostructures; D019736:Prostheses and Implants / Q000009:adverse effects*
D001672:Biocompatible Materials