title: [Sandimmun vs Neoral, comparison between two types of cyclosporine in patients with kidney transplantation].
abstract: We present a comparative trial between Sandimmun, the original cyclosporine presentation, and a modified one, called Neoral, in microemulsion, to increase the blood absortion and stability of the product. We built for each product, an absorption kinetic curve and we applied it to three patients with stable renal function, using the same dosage that was used for ciclosporine. We observed a greater absorption and stability in the blood levels of Neoral. We analyzed hundred blood samples in 25 patients and we found a higher level of this product; this lead us to make possible that in 72% of the patients we could diminish the daily dosis in 5 to 10%. The patient's renal function was stable and no complications or secondary effects were present with Neoral.
authors.affiliation: Servicio de Nefrología, C. H. DRAAM.
authors.forename: C
authors.initials: C
authors.lastname: Cuero
authors.forename: A
authors.initials: A
authors.lastname: Vernaza
authors.forename: E
authors.initials: E
authors.lastname: Pérez
authors.forename: M
authors.initials: M
authors.lastname: Díaz Isaacs
mesh_terms: D000328:Adult; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine