Translational repression by Bicoid: competition for the cap.
Eggs and embryos have proven to be fertile grounds for discovery and characterization of a variety of mechanisms used in posttranscriptional control of gene expression, mechanisms that are central to embryonic patterning and development. In this issue of Cell, solve a puzzle surrounding the action of the Drosophila Bicoid morphogen in formation of the Caudal protein gradient and in doing so describe a novel mechanism of translational repression.
Macdonald
Paul M
PM
D000818:Animals; D019521:Body Patterning / Q000502:physiology; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics / Q000378:metabolism; D039561:Eukaryotic Initiation Factor-4E / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000235:genetics / Q000502:physiology*; D014176:Protein Biosynthesis / Q000235:genetics*; D039381:RNA Cap-Binding Proteins / Q000378:metabolism; D012315:RNA Caps / Q000502:physiology; D012333:RNA, Messenger / Q000378:metabolism; D015534:Trans-Activators / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics
D029721:Drosophila Proteins; D039561:Eukaryotic Initiation Factor-4E; D018398:Homeodomain Proteins; D039381:RNA Cap-Binding Proteins; D012315:RNA Caps; D012333:RNA, Messenger; D015534:Trans-Activators; D014157:Transcription Factors; C056478:bcd protein, Drosophila; C084564:cad protein, Drosophila