title: Near-real-time radiotherapy dosimetry using optically stimulated luminescence of Al2O3:C: mathematical models and preliminary results.
abstract: In this paper we report investigations aimed toward applying optically stimulated luminescence (OSL) of Al2O3:C for near-real-time medical dosimetry, especially in radiotherapy. The classical mathematical model normally used for the description of OSL phenomena was expanded to predict the behavior of the luminescence signal in the case when the OSL sample is simultaneously irradiated and optically stimulated. The predictions obtained were used to develop different measurement approaches and correction algorithms for the luminescence signals, thus enabling dose estimation from OSL during rather then after the irradiation procedure. Radiation probes with diameters of less than 1 mm, suitable for the envisioned in-vivo measurements were constructed by attaching small Al2O3:C crystals to optical fiber cables. The OSL fiber probes and a purpose-built, portable OSL stimulation and readout system were used to measure doses at speeds up to 1 data point every 3s, under irradiation at dose rates of the same order of magnitude as those found in conventional radiotherapy techniques. The corrected OSL signal was found to be proportional to the absorbed dose, and accurately followed sudden transitions in the irradiation dose rate.
authors.affiliation: Department of Physics, Oklahoma State University, 145 PS II, Stillwater, Oklahoma 74078, USA. rgaza@mdanderson.org
authors.forename: R
authors.initials: R
authors.lastname: Gaza
authors.forename: S W S
authors.initials: SW
authors.lastname: McKeever
authors.forename: M S
authors.initials: MS
authors.lastname: Akselrod
mesh_terms: D000465:Algorithms; D000537:Aluminum Oxide / Q000737:chemistry*; D005373:Film Dosimetry; D007834:Lasers; D049449:Luminescence; D008163:Luminescent Measurements; D015233:Models, Statistical; D008962:Models, Theoretical; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D013326:Strontium Radioisotopes; D013819:Thermoluminescent Dosimetry / Q000379:methods*; D013997:Time Factors
chemical_list: D013326:Strontium Radioisotopes; D000537:Aluminum Oxide