Identification of the MHC class I B locus in cynomolgus monkeys.
By determining the nucleotide sequences of more than 700 cDNA clones isolated from 16 cynomolgus monkeys, we identified 26 Mafa-B alleles. In addition, nine sequences with similarity to Mamu-I alleles were identified. Since multiple Mafa-B alleles were found in each individual, it was strongly suggested that the cynomolgus MHC class I B locus might be duplicated and that the Mafa-I locus was derived from the B locus by gene duplication, as in the case of the Mamu-I locus of rhesus monkeys.
Uda
Akihiko
A
Department of Veterinary Science, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo, 162-8640, Japan.
Tanabayashi
Kiyoshi
K
Fujita
Osamu
O
Hotta
Akitoyo
A
Terao
Keiji
K
Yamada
Akio
A
D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018076:DNA, Complementary / Q000235:genetics; D005260:Female; D020440:Gene Duplication; D005805:Genes, MHC Class I; D006239:Haplotypes; D008252:Macaca fascicularis / Q000235:genetics* / Q000276:immunology*; D008253:Macaca mulatta / Q000235:genetics / Q000276:immunology; D008297:Male; D008969:Molecular Sequence Data; D010375:Pedigree; D010802:Phylogeny; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity
D018076:DNA, Complementary