[Treatment of hemorrhagic cystitis secondary to cyclophosphamide. Literature review with regard to a case].
There are extreme situations in the clinical treatment of intractable hematuria (fortunately not a common disease nowadays), in which even benign process may represent a serious risk to the life of the patient and where certain aggressive procedures like cystectomy have to be considered. Our objective in this paper is to review the different existing therapeutic alternatives for the treatment of an intense type of hematuria which does not yield to continuous saline serum irrigation. This study is partly based on a recent real clinical case in which, after the administration of cyclophosphamide to a young patient with recurrent and intense hematuria, the excretion was controlled through intravesical alum irrigation of thus avoiding cystectomy, a very aggressive surgical procedure with many after-effects.
Serrano Frago
P
P
Servicio de Urología, Hospital Universiario Miguel Servet, Zaragoza. pserranof@comz.org
Allepuz Losa
C
C
Gil Martínez
P
P
Allué López
M
M
Mallén Mateo
E
E
Sancho Serrano
C
C
Rioja Sanz
L A
LA
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000328:Adult; D000534:Alum Compounds / Q000008:administration & dosage; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects*; D003520:Cyclophosphamide / Q000009:adverse effects*; D003556:Cystitis / Q000139:chemically induced* / Q000188:drug therapy; D006417:Hematuria / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D008297:Male; D007507:Therapeutic Irrigation; D016896:Treatment Outcome
D000276:Adjuvants, Immunologic; D000534:Alum Compounds; D018906:Antineoplastic Agents, Alkylating; C041524:aluminum sulfate; D003520:Cyclophosphamide