title: Antiviral evaluation of plants from Brazilian Atlantic Tropical Forest.
abstract: The antiviral activity of six medicinal plants from Brazilian Atlantic Tropical Forest was investigated against two viruses: herpes simplex virus type 1 (HSV-1) and poliovirus type 2 (PV-2). Cuphea carthagenensis and Tillandsia usneoides extracts showed the best antiherpes activity. T. usneoides dichloromethane, ethyl acetate and n-butanol extracts, and Lippia alba n-butanol extract showed inhibition of HSV-1, strain 29R/acyclovir resistant. In addition, only L. alba ethyl acetate extract showed antipoliovirus activity. These results corroborate that medicinal plants can be a rich source of potential antiviral compounds.
authors.affiliation: Laboratório de Virologia Aplicada, Universidade Federal de Santa Catarina, Campus Universitário Trindade, Florianópolis, SC, Brazil.
authors.forename: C R
authors.initials: CR
authors.lastname: Andrighetti-Fröhner
authors.forename: T C M
authors.initials: TC
authors.lastname: Sincero
authors.forename: A C
authors.initials: AC
authors.lastname: da Silva
authors.forename: L A
authors.initials: LA
authors.lastname: Savi
authors.forename: C M
authors.initials: CM
authors.lastname: Gaido
authors.forename: J M R
authors.initials: JM
authors.lastname: Bettega
authors.forename: M
authors.initials: M
authors.lastname: Mancini
authors.forename: M T R
authors.initials: MT
authors.lastname: de Almeida
authors.forename: R A
authors.initials: RA
authors.lastname: Barbosa
authors.forename: M R
authors.initials: MR
authors.lastname: Farias
authors.forename: C R M
authors.initials: CR
authors.lastname: Barardi
authors.forename: C M O
authors.initials: CM
authors.lastname: Simões
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D001938:Brazil; D024882:Drug Resistance, Viral; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D019684:Magnoliopsida / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D017955:Poliovirus / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D010936:Plant Extracts