title: Synthesis and pharmacology of new camptothecin drugs.
abstract: Camptothecin (CPT) drugs exhibit antineoplastic activity against colorectal, breast, lung and ovarian cancers. This review briefly summarizes the pharmacology of CPT drugs, examines four strategies and methods for the synthesis of camptothecins, and finally discusses homocamptothecins and silatecans, two new classes of CPT analog.
authors.affiliation: Radiology Laboratory, California Pacific Medical Center Research Institute, San Francisco, CA 94118, USA.
authors.forename: Russell W
authors.initials: RW
authors.lastname: Driver
authors.forename: Li-Xi
authors.initials: LX
authors.lastname: Yang
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000494:pharmacology*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D017646:Organosilicon Compounds / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017646:Organosilicon Compounds; C120029:homocamptothecin; D002166:Camptothecin