title: Iron overload.
abstract: Iron overload disorders represent a heterogenous group of conditions resulting from inherited and acquired causes. With the discovery of new proteins and genetic defects we have gained greater insight into their causation at the molecular level and the complex mechanisms of normal and disordered iron homeostasis. Here we review the normal mechanisms and regulation of gastrointestinal iron absorption and liver iron transport and their dysregulation in iron overload states. Advances in the understanding of the natural history of iron overload disorders and new methods for clinical detection and management of hereditary hemochromatosis are also reviewed.
authors.affiliation: School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital Campus, P.O. Box 480, Fremantle 6959, Western Australia.
authors.forename: Chiang W
authors.initials: CW
authors.lastname: Siah
authors.forename: Debbie
authors.initials: D
authors.lastname: Trinder
authors.forename: John K
authors.initials: JK
authors.lastname: Olynyk
mesh_terms: D002570:Ceruloplasmin / Q000172:deficiency / Q000378:metabolism; D006432:Hemochromatosis / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007501:Iron / Q000378:metabolism*; D019190:Iron Overload / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D008107:Liver Diseases / Q000378:metabolism / Q000473:pathology; D008954:Models, Biological; D014168:Transferrin / Q000172:deficiency / Q000378:metabolism
chemical_list: D014168:Transferrin; D007501:Iron; D002570:Ceruloplasmin