A functional polymorphism of the NFKB1 promoter is not associated with ulcerative colitis in a Spanish population.
BACKGROUND
This study investigated the influence of the NFKB1-94ins/delATTG in the susceptibility/phenotype to ulcerative colitis.


METHODS
We analyzed the distribution of -94ins/delATTG NFKB1 in 258 patients and 264 healthy controls from southern Spain by a polymerase chain reaction-fluorescent method.


RESULTS
The genotype and allele frequencies of -94ins/delATTG did not significantly differ between patients and controls. In fact, the frequency of the -94delATTG allele was almost identical in both groups (34.8% and 35.4%, respectively), and the del/del genotype was underrepresented in UC patients (11.2% versus 14%). In addition, no association of this polymorphism was found with any of the clinical parameters analyzed.


CONCLUSIONS
These results suggest that the NFKB1 -94ins/delATTG gene variation, previously associated with UC susceptibility in North Americans, does not influence either susceptibility or phenotype of UC in the Spanish population.
Oliver
Javier
J
Instituto de Parasitología y Biomedicina López Neyra, Granada, Spain.
Gómez-García
María
M
Paco
Laura
L
López-Nevot
Miguel A
MA
Piñero
Alexis
A
Correro
Francisco
F
Martín
Leopoldo
L
Brieva
José A
JA
Nieto
Antonio
A
Martín
Javier
J
D000328:Adult; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000208:ethnology / Q000209:etiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D052002:NF-kappa B p50 Subunit; D010641:Phenotype; D011110:Polymorphism, Genetic; D013030:Spain; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology*
D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human; D014157:Transcription Factors