title: Acute felbamate overdose with crystalluria.
abstract: A 3-year-old child developed vomiting, ataxia, and crystalluria after ingestion of approximately 232 mg/kg of felbamate elixir. High-powered polarization microscopy of the urine revealed sharp, needle-like crystals. The analysis of the urine crystals showed unchanged felbamate (80.9%), monocarbamate felbamate (18.8%), and trace amounts of mercapturic acid conjugates of the metabolite 2-phenylpropenal (0.1%). The serum felbamate level 15 h after ingestion was 138 mg/L. Crystalluria and hematuria resolved with intravenous fluid therapy, and the child recovered within 24 h.
authors.affiliation: California Poison Control System, Department of Clinical Pharmacy, University of California, San Francisco, CA 94143-1369, USA. kmpcc@itsa.ucsf.edu
authors.forename: Kathryn H
authors.initials: KH
authors.lastname: Meier
authors.forename: Kent R
authors.initials: KR
authors.lastname: Olson
authors.forename: Jean L
authors.initials: JL
authors.lastname: Olson
mesh_terms: D000927:Anticonvulsants / Q000097:blood / Q000506:poisoning*; D002675:Child, Preschool; D003460:Crystallization; D062787:Drug Overdose; D000078328:Felbamate; D005260:Female; D005440:Fluid Therapy / Q000379:methods; D006801:Humans; D007262:Infusions, Intravenous; D008859:Microscopy, Polarization; D048448:Phenylcarbamates; D011041:Poisoning / Q000209:etiology* / Q000628:therapy / Q000652:urine; D011409:Propylene Glycols / Q000032:analysis / Q000097:blood / Q000506:poisoning*; D016896:Treatment Outcome; D014545:Urinary Calculi / Q000209:etiology* / Q000473:pathology / Q000652:urine
chemical_list: D000927:Anticonvulsants; D048448:Phenylcarbamates; D011409:Propylene Glycols; D000078328:Felbamate