Artificial metallonucleases.
The development of synthetic agents able to hydrolytically cleave DNA with high efficiency and selectivity is a fascinating challenge that will show the way to obtaining artificial nucleases able to compete with the natural enzymes. This Feature Article highlights the progress reported toward the realization of synthetic nucleases with particular attention to the strategies that can be pursued to improve efficiency and sequence selectivity.
Mancin
Fabrizio
F
Dipartimento di Scienze Chimiche and Istituto CNR di Tecnologia delle Membrane - Sezione di Padova, Università di Padova, via Marzolo 1, I-35131 Padova, Italy. fabrizio.mancin@unipd.it
Scrimin
Paolo
P
Tecilla
Paolo
P
Tonellato
Umberto
U
D002384:Catalysis; D004247:DNA / Q000737:chemistry; D003851:Deoxyribonucleases / Q000138:chemical synthesis / Q000737:chemistry*; D006868:Hydrolysis; D008024:Ligands; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D013379:Substrate Specificity
D008024:Ligands; D008670:Metals; D004247:DNA; D003851:Deoxyribonucleases