title: A technique for retroperitoneal pancreas transplantation with portal-enteric drainage.
abstract: BACKGROUND
  Pancreas transplantation (PTx) with portal-enteric drainage (PED) has been associated with difficulties in respect to arterial anastomosis and graft accessibility for percutaneous biopsy. We describe a new technique that circumvents these difficulties.
  
  
  METHODS
  Between April 2001 and April 2004, a total of 113 recipients were scheduled for PTx with PED. The superior mesenteric vein was approached from the right retroperitoneal aspect instead of from the anterior transmesenteric route. The pancreas graft was eventually placed in the right retroperitoneal space, being covered by the ascending colon and its mesentery.
  
  
  RESULTS
  One hundred ten (97.3%) PTx were performed as planned. Systemic venous effluent was preferred in three patients because of incidental diagnosis of liver cirrhosis during surgery (n=1) and severe obesity (body mass index>35 kg/m2) (n=2). The Y iliac artery graft was kept as short as possible, and arterial anastomosis was always performed with ease. After a mean follow-up period of 21.2+/-19.9 months, the relaparotomy rate was 13.6%. No patient died after repeat surgery, and none required multiple relaparotomies. Overall, 10 grafts were lost because of acute rejection (n=3), chronic rejection (n=2), venous thrombosis (n=2), recipient death (n=2), and late (6-month) arterial thrombosis (n=1). One-year patient and graft survival were 98.1% and 90.7%, respectively.
  
  
  CONCLUSIONS
  Our data confirm that PTx with PED is not associated with an increased risk. The technique described has distinctive technical advantages and should be included in the repertoire of PTx.
authors.affiliation: Divisione di Chirurgia Generale e Trapianti, Università di Pisa, Ospedale di Cisanello, Pisa, Italy. u.boggi@med.unipi.it
authors.forename: Ugo
authors.initials: U
authors.lastname: Boggi
authors.forename: Fabio
authors.initials: F
authors.lastname: Vistoli
authors.forename: Stefano
authors.initials: S
authors.lastname: Signori
authors.forename: Marco
authors.initials: M
authors.lastname: Del Chiaro
authors.forename: Alessandro
authors.initials: A
authors.lastname: Campatelli
authors.forename: Gabriella
authors.initials: G
authors.lastname: Amorese
authors.forename: Emanuele
authors.initials: E
authors.lastname: Marciano
authors.forename: Alberto
authors.initials: A
authors.lastname: Coppelli
authors.forename: Carla
authors.initials: C
authors.lastname: Tregnaghi
authors.forename: Gaetano
authors.initials: G
authors.lastname: Rizzo
authors.forename: Piero
authors.initials: P
authors.lastname: Marchetti
authors.forename: Franco
authors.initials: F
authors.lastname: Mosca
mesh_terms: D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery; D004322:Drainage; D005260:Female; D006085:Graft Survival; D006801:Humans; D008297:Male; D016035:Pancreas Transplantation / Q000379:methods* / Q000401:mortality / Q000502:physiology; D011169:Portal Vein; D012086:Reoperation / Q000706:statistics & numerical data; D012187:Retroperitoneal Space; D012189:Retrospective Studies; D016019:Survival Analysis; D013997:Time Factors