title: The first solid-phase synthesis of bis(oxazolinyl)pyridine ligands.
abstract: Chiral Pybox (pyridine-2,6-bis(oxazoline)) ligands can be cleanly and efficiently prepared on polystyrene support via a five-step solid-phase synthetic sequence. Cu(I)-complexed polymer-bound Pybox was used as a catalyst in the first heterogeneously catalyzed asymmetric addition of alkynes to imines. Best enantioselectivity was observed with (t)Bu-substituted oxazolines.
authors.affiliation: School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv 69978, Israel.
authors.forename: Avi
authors.initials: A
authors.lastname: Weissberg
authors.forename: Baruch
authors.initials: B
authors.lastname: Halak
authors.forename: Moshe
authors.initials: M
authors.lastname: Portnoy