title: Relationship between serum butyrylcholinesterase and the metabolic syndrome.
abstract: OBJECTIVE
  To identify independent predictors of serum butyrylcholinesterase (BuChE) activity and examine its relationship with the metabolic syndrome.
  
  
  METHODS
  Serum BuChE activity was measured and metabolic syndrome risk factors were assessed in 1097 healthy subjects recruited from the Newfoundland adult population.
  
  
  RESULTS
  Serum BuChE activity was related to insulin homeostasis and correlated with fasting insulin levels (r = 0.266, P < 0.001) and insulin resistance (HOMA-R) index (r = 0.292, P < 0.001) and was higher in individuals with risk factors for the metabolic syndrome. BuChE activity was higher in males than in females and correlated most strongly with serum triglyceride levels (r = 0.363, P < 0.001) and indicators of abdominal obesity (r = 0.355, P < 0.001). Percent trunk fat (beta = 0.185, P < 0.001), triglyceride levels (beta = 0.225, P < 0.001), sex (beta = -0.202, P = 0.001), glucose (beta = 0.209, P < 0.001), insulin (beta = 0.360, P = 0.011), HOMA-R (beta = -0.319, P = 0.044), and age (beta = 0.086, P = 0.002) were independent predictors of BuChE activity.
  
  
  CONCLUSIONS
  These results suggest the involvement of BuChE in the pathophysiological process constituting the metabolic syndrome. Whether increased BuChE activity precedes or follows the development of risk factors is not known.
authors.affiliation: Division of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada A1B 3V6. erandell@mun.ca
authors.forename: Edward W
authors.initials: EW
authors.lastname: Randell
authors.forename: Maria S
authors.initials: MS
authors.lastname: Mathews
authors.forename: Hongwei
authors.initials: H
authors.lastname: Zhang
authors.forename: Jim S
authors.initials: JS
authors.lastname: Seraj
authors.forename: Guang
authors.initials: G
authors.lastname: Sun
mesh_terms: D000015:Abnormalities, Multiple; D000328:Adult; D002091:Butyrylcholinesterase / Q000097:blood* / Q000378:metabolism; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000378:metabolism*; D008875:Middle Aged; D012727:Sex Characteristics
chemical_list: D007328:Insulin; D002091:Butyrylcholinesterase