Relation of acute pericardial disease to malignancy.
Neoplastic etiology was found in 33 of 450 patients with acute pericardial disease (7.3%). Acute pericardial disease was the first manifestation of previously unknown malignancies in 18 of 450 patients (4.0%), and lung cancer was the most common malignancy (72.2%, p = 0.02). The following clinical characteristics were associated with a greater probability of a neoplastic etiology: a history of malignancy (odds ratio [OR] 19.8), cardiac tamponade at presentation (OR 7.0), a lack of response to nonsteroidal anti-inflammatory drugs, and recurrent or incessant pericarditis (OR 10.0). A similar prognosis was found in patients with or without a history of known cancer.
Imazio
Massimo
M
Cardiology Department, Maria Vittoria Hospital, Torino, Italy. imazio@tin.it
Demichelis
Brunella
B
Parrini
Iris
I
Favro
Elisa
E
Beqaraj
Federico
F
Cecchi
Enrico
E
Pomari
Franco
F
Demarie
Daniela
D
Ghisio
Aldo
A
Belli
Riccardo
R
Bobbio
Marco
M
Trinchero
Rita
R
D000208:Acute Disease; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002305:Cardiac Tamponade / Q000150:complications; D005260:Female; D006331:Heart Diseases / Q000209:etiology; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications*; D010496:Pericardium; D011379:Prognosis; D011446:Prospective Studies; D012008:Recurrence
D000894:Anti-Inflammatory Agents, Non-Steroidal