[The occurrence rate of HGV/GBV-C RNA and risk factors in patients of narcological dispensary in Novosibirsk].
The occurrence rate of HGV/GBV-C RNA, genotypic variety of isolates and various risk factors of infection with HGV/GBV-C were evaluated in 500 patients of the narcological dispensary of Novosibirsk. The occurrence rate of HGV/GBV-C RNA among all examined blood sera was 33.6%. At the same time in blood sera with HCV markers the occurrence rate of HGV/ GBV-C was 42.9% and in sera with negative results for markers HCV--25%. For gene typing of obtained isolates the direct sequencing of the amplification products of fragment NS3B and the phylogenetic analysis of the sequences thus obtained were used. Almost all isolates subjected to gene typing belonged to genotype 2, widespread in Europe, and only 1 isolate was classified with genotype 4. Statistically significant (p<0.05) risk of HGV/GBV-C infection among the examined subjects was linked with the intravenous use of drugs (OR 2.15), risky sexual behavior (OR 1.8) and the presence of virus hepatitis C (OR 2.26).
Kachko
A V
AV
Ershov
A E
AE
Gavrilova
I V
IV
Shustov
A V
AV
Kochneva
G V
GV
Sivolobova
G F
GF
Grazhdantseva
A A
AA
Bukin
V N
VN
Komissarova
M A
MA
Netesov
S V
SV
D000293:Adolescent; D000328:Adult; D000553:Ambulatory Care; D015897:Comorbidity; D005260:Female; D018177:Flavivirus Infections / Q000097:blood / Q000453:epidemiology / Q000821:virology*; D029407:GB virus C / Q000235:genetics* / Q000302:isolation & purification; D005838:Genotype; D006526:Hepatitis C / Q000453:epidemiology / Q000821:virology; D006525:Hepatitis, Viral, Human / Q000097:blood / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009294:Narcotics; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics*; D012307:Risk Factors; D012800:Siberia / Q000453:epidemiology; D015819:Substance Abuse, Intravenous / Q000097:blood / Q000453:epidemiology / Q000821:virology*
D009294:Narcotics; D012367:RNA, Viral