Aryl-aryl coupling via directed lithiation and oxidation.
Aryl lithium reagents formed by directed lithiation reactions undergo transmetallation with copper(I) salts to form organocuprates, which may be efficiently oxidized to yield ortho-substituted biaryls.
Surry
David S
DS
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
Fox
David J
DJ
Macdonald
Simon J F
SJ
Spring
David R
DR
D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis*; D008094:Lithium / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction
D006841:Hydrocarbons, Aromatic; D008094:Lithium