title: Pharmacokinetics and normal scintigraphic appearance of 99mTc aprotinin.
abstract: OBJECTIVE
  To confirm the pharmacokinetics and biodistribution of 99mTc aprotinin in normal volunteers and to determine the optimum time for scanning post-injection, prior to further investigations of 99mTc aprotinin as an imaging agent for amyloidosis.
  
  
  METHODS
  Five patients (three men and two women, average age 49 years, age range 38-66 years) without a history of amyloidosis or any of the associated diseases, were included in this prospective study. Blood and urine were collected and images were performed of the whole body and wrists.
  
  
  CONCLUSIONS
  Normal biodistribution of 99mTc aprotinin includes early cardiac and lung activity in the blood pool phase with subsequent hepatic activity and renal excretion with variable splenic activity. There is variable bowel uptake on later images. The best quality images were obtained 90 min post-intravenous administration, and this is likely to be the optimum time for clinical imaging.
authors.affiliation: Department of Nuclear Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
authors.forename: Sally M
authors.initials: SM
authors.lastname: Sojan
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Smyth
authors.forename: Chris
authors.initials: C
authors.lastname: Tsopelas
authors.forename: David
authors.initials: D
authors.lastname: Mudge
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Collins
authors.forename: Barry E
authors.initials: BE
authors.lastname: Chatterton
mesh_terms: D000328:Adult; D000368:Aged; D007611:Aprotinin / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009928:Organ Specificity; D015609:Organotechnetium Compounds / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D019275:Radiopharmaceuticals / Q000097:blood / Q000493:pharmacokinetics / Q000652:urine; D012016:Reference Values; D014018:Tissue Distribution
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C041381:technetium Tc 99m aprotinin; D007611:Aprotinin