title: [Influence of GnRH analogue on the intensification of endometriosis symptoms and infertility treatment].
abstract: OBJECTIVE
  The aim of this study was to evaluate the influence of the treatment with oral doses of 50 mg GnRH analogue on the intensification of endometriosis symptoms and infertility amongst women with evident symptoms of endometriosis in comparison with placebo group. A group of 34 women at the age from 18 to 45 were introduced into the study. The inclusion criteria for investigated population contained: endometriosis symptoms, endometriosis diagnosed by laparoscopy, its surgical or pharmacological treatment, negative pregnancy test score and regular menses. The patients were divided into 2 groups: investigated group and control group. Women completed "Diary" every day in which they estimated main endometriosis symptoms: dysmenorrhea, dyspareunia, pelvic pain and vaginal bleeding (according to Pain Grading Scale). The intensification of dysmenorrhea and vaginal bleeding was reduced in the investigated group in comparison with control one. These differences were statistically significant. Although the extremity of dyspareunia was decreased in two groups, this correlation was statistically significant only in the investigated group. Pelvic pain evaluation showed that its level was lower in the investigated group (p > 0.05). It was found that 11 women (investigated group) and 5 women (control group) got pregnant after the period of 12-week treatment.
  
  
  CONCLUSIONS
  GnRH analogues have an efficient influence on the reduction of endometriosis symptoms. GnRH analogues could be used in the management of infertility.
authors.affiliation: Z Katedry Zdrowia Kobiety Slaskiej Akademii Medycznej w Katowicach. cor111@poczta.onet.pl
authors.forename: Violetta
authors.initials: V
authors.lastname: Skrzypulec
authors.forename: Aneta
authors.initials: A
authors.lastname: Walaszek
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Drosdzol
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Nowosielski
authors.forename: Bogusława
authors.initials: B
authors.lastname: Piela
authors.forename: Wioletta
authors.initials: W
authors.lastname: Rozmus-Warcholińska
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D004305:Dose-Response Relationship, Drug; D004412:Dysmenorrhea / Q000188:drug therapy; D004414:Dyspareunia / Q000188:drug therapy; D004715:Endometriosis / Q000188:drug therapy*; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage*; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives*; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*; D008598:Menstruation / Q000187:drug effects; D008875:Middle Aged; D011044:Poland; D011247:Pregnancy; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D005300:Fertility Agents, Female; D007987:Gonadotropin-Releasing Hormone