title: Aberrant expression of tumor suppressor genes and their association with chimeric oncogenes in pediatric acute lymphoblastic leukemia.
abstract: Aberrant expression of tumor suppressor genes WT 1, RB 1, p53, homozygous deletion of p16 gene and their relationship with expression of oncogenes BCR-ABL, TEL-AML 1, MLL-AF 4, E2A-PBX 1, SIL-TAL 1 were determined in bone marrow samples of children with de novo B-lineage (n=170) and T-lineage (n=25) acute lymphoblastic leukemia (ALL). In contrast to expression of chimeric oncogenes alterations in p16, WT 1, RB 1 and p53 expression were T/B-lineage-unrestricted. Significant association between expression of MLL-AF 4 and WT 1, E2A-PBX 1 and p53; SIL-TAL 1 and homozygous deletion of p16 has been demonstrated.
authors.affiliation: Laboratory of Molecular Biology, Belarussian Research Center for Pediatric Oncology and Hematology, P.O. Lesnoye, Minsk 223040, Belarus. akustanovich@tut.by
authors.forename: Anatoly M
authors.initials: AM
authors.lastname: Kustanovich
authors.forename: Tatjana V
authors.initials: TV
authors.lastname: Savitskaja
authors.forename: Oleg I
authors.initials: OI
authors.lastname: Bydanov
authors.forename: Michael V
authors.initials: MV
authors.lastname: Belevtsev
authors.forename: Michael P
authors.initials: MP
authors.lastname: Potapnev
mesh_terms: D000293:Adolescent; D045744:Cell Line, Tumor; D002648:Child; D002675:Child, Preschool; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics; D005260:Female; D017353:Gene Deletion; D015972:Gene Expression Regulation, Neoplastic; D016161:Genes, Retinoblastoma / Q000235:genetics; D016147:Genes, Tumor Suppressor; D016162:Genes, Wilms Tumor; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D007223:Infant; D008297:Male; D009857:Oncogenes / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000235:genetics*; D011379:Prognosis
chemical_list: D019941:Cyclin-Dependent Kinase Inhibitor p16