Recognition of homo-polynucleotides containing adenine by a phenanthridinium bis-uracil conjugate in aqueous media.
Among novel bis-nucleobase-phenanthridinium conjugates bis-uracil analogue stabilized significantly more effective poly-dA-poly-dT and poly-AH(+)-poly-AH(+) than adenine analogue and reference compound . For the alternating poly-dAdT-poly-dAdT however, the binding preference is lost, pointing to the importance of specific interactions of uracils of with homopolynucleotides containing consecutive adenines.
Tumir
Lidija-Marija
LM
Laboratory of Supramolecular and Nucleoside Chemistry, Department of Chemistry and Biochemistry, Ruder Bosković Institute, HR 10002 Zagreb, P.O.B. 180, Croatia.
Piantanida
Ivo
I
Juranović
Iva
I
Meić
Zlatko
Z
Tomić
Sanja
S
Zinić
Mladen
M
D000225:Adenine / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D010617:Phenanthridines / Q000737:chemistry*; D011061:Poly A / Q000737:chemistry; D011067:Poly dA-dT / Q000737:chemistry; D011089:Polydeoxyribonucleotides / Q000737:chemistry*; D014498:Uracil / Q000031:analogs & derivatives* / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D010617:Phenanthridines; D011089:Polydeoxyribonucleotides; C014740:phenanthridinium; D014867:Water; D011061:Poly A; C015465:poly(dA); D011067:Poly dA-dT; D014498:Uracil; D000225:Adenine