title: [Progress in the study of ryanodine receptor-related muscle diseases].
abstract: Ryanodine receptor (RyR), a calcium release channel within the sarcoplasmic reticulum (SR) membrane, is a key protein in skeletal and cardiac excitation-contraction coupling. The structural and functional changes of RyR can result in decoupling of excitation-contraction, and lead to muscle diseases. Current study confirms that RyR is related to the pathogenesis of these diseases. In this review, we look at the current progress in the study on RyR and these diseases to provide the molecular basis in the prevention and therapy of these diseases.
authors.affiliation: Department of Biophysics, Peking University Health Science Center, Beijing 100083.
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Han
authors.forename: Chang-Cheng
authors.initials: CC
authors.lastname: Yin
mesh_terms: D000818:Animals; D005334:Fever / Q000378:metabolism; D006333:Heart Failure / Q000378:metabolism; D006801:Humans; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology*; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D020512:Myopathy, Central Core / Q000378:metabolism; D019837:Ryanodine Receptor Calcium Release Channel / Q000502:physiology*; D012519:Sarcoplasmic Reticulum / Q000378:metabolism*
chemical_list: D019837:Ryanodine Receptor Calcium Release Channel