title: [Study on high mobility group-1 protein in patients with multiple trauma].
abstract: OBJECTIVE
  To study the change in serum high mobility group-1 (HMG-1) protein in patients with multiple trauma and determine its relationship to severity of trauma and multiple organ dysfunction syndrome (MODS).
  
  
  METHODS
  In 33 cases, HMG-1 levels were determined on 1, 3, 7 days after trauma respectively. The values of injury severity score (ISS), acute physiology and chronic health evaluation II (APACHE II) and systemic inflammatory response syndrome (SIRS) score were determined. Meanwhile, the occurrence of organ dysfunction was noted.
  
  
  RESULTS
  The level of serum HMG-1 in patients with multiple trauma was much higher than that of normal controls, and also in those with organ dysfunction. HMG-1 and APACHE II were positively correlated (r=0.495, P=0.016). The level of serum HMG-1 and APACHE II value were much higher in patients with organ dysfunction than those of normal organ function, but there was no significant difference in SIRS score between the two groups (P=0.105).
  
  
  CONCLUSIONS
  Serum HMG-1 increases in patients with trauma and is positively correlated with severity of trauma. Serial determination of HMG-1 is helpful to discover clinical infection earlier. HMG-1 can be used as a warning indicator of the onset of MODS.
authors.affiliation: Department of Trauma, Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Fei
authors.forename: Hong-jun
authors.initials: HJ
authors.lastname: Yu
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
authors.forename: Xian-kai
authors.initials: XK
authors.lastname: Huang
authors.forename: Hua-ping
authors.initials: HP
authors.lastname: Liang
authors.forename: Yao-guang
authors.initials: YG
authors.lastname: Jiang
mesh_terms: D018806:APACHE; D000328:Adult; D005260:Female; D024243:HMGB1 Protein / Q000097:blood*; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology / Q000503:physiopathology; D009104:Multiple Trauma / Q000097:blood* / Q000150:complications; D011379:Prognosis; D055815:Young Adult
chemical_list: D024243:HMGB1 Protein