title: Retrospective study of 151 patients with cutaneous leishmaniasis treated with meglumine antimoniate.
abstract: We retrospectively analyzed a series of 151 cases of cutaneous leishmaniasis treated between 1967 and 1982. One-hundred-and-thirty-nine (92%) patients presented with active lesions and were treated with daily doses of meglumine antimoniate: 81 adults received a 5-ml vial IM and 58 children received 1 to 5 ml. Forty-five (32.4%) patients underwent continuous treatment with meglumine antimoniate for 25 to 116 days without rest intervals, and 94 (67.6%) intermittent treatment with 2 to 5 series of meglumine antimoniate. Intermittent series could include schedules of daily IM applications for 10 to 25 days each and intervals varying from 10 to 60 days. Antimony dose was calculated for 66 (47.5%) patients and ranged from 3.9 to 28.7 Sb5+/kg/day. Of these, 35 patients received > or =10 mg and 31 patients < 10 mg Sb5+/kg/day. Median time of healing was longer for lesions on the legs and feet -- 67.5 days versus 48.7 days (p < 0.001) for other sites. However, there were no significant differences in the median time of healing between adults and children, intermittent and continuous regimens or high and low antimony doses. Fifty-one patients were reassessed 5 to 14 years after treatment and showed no evidence of disease. These results support further investigation (clinical trials) on treatment using low doses of antimony.
authors.affiliation: Centro de Referências em Leishmanioses, Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil. armando@ipec.fiocruz.br
authors.forename: Armando de Oliveira
authors.initials: Ade O
authors.lastname: Schubach
authors.forename: Keyla B Feldman
authors.initials: KB
authors.lastname: Marzochi
authors.forename: João Soares
authors.initials: JS
authors.lastname: Moreira
authors.forename: Tânia Maria Pacheco
authors.initials: TM
authors.lastname: Schubach
authors.forename: Marcelo Lodi
authors.initials: ML
authors.lastname: Araújo
authors.forename: Antônio Carlos Francesconi do
authors.initials: AC
authors.lastname: Vale
authors.forename: Sonia Regina Lambert
authors.initials: SR
authors.lastname: Passos
authors.forename: Mauro Célio de Almeida
authors.initials: MC
authors.lastname: Marzochi
mesh_terms: D000293:Adolescent; D000328:Adult; D000981:Antiprotozoal Agents / Q000008:administration & dosage*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy*; D008297:Male; D008536:Meglumine / Q000008:administration & dosage*; D000077485:Meglumine Antimoniate; D009942:Organometallic Compounds / Q000008:administration & dosage*; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate