title: A prenylbisabolane with NF-kappaB inhibiting properties from Cascarilla (Croton eluteria).
abstract: Investigation of the bark of Croton eluteria Bennett for biologically active compounds has led to the isolation of the new prenylbisabolane 3, whose structure was assessed by spectroscopic methods. The corresponding known enone 4 and the eudesmane sesquiterpene 2 were also obtained. Compound 3 proved active in selectively inhibiting the induction of NF-kappaB by tumor necrosis factor-alpha in T cells.
authors.affiliation: Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, Via D. Montesano 49, I-80131 Napoli, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Campagnuolo
authors.forename: Ernesto
authors.initials: E
authors.lastname: Fattorusso
authors.forename: Francesca
authors.initials: F
authors.lastname: Petrucci
authors.forename: Orazio
authors.initials: O
authors.lastname: Taglialatela-Scafati
authors.forename: Giovanni
authors.initials: G
authors.lastname: Appendino
authors.forename: Nieves
authors.initials: N
authors.lastname: Marquez
authors.forename: Eduardo
authors.initials: E
authors.lastname: Muñoz
mesh_terms: D002453:Cell Cycle / Q000187:drug effects; D002467:Cell Nucleus / Q000378:metabolism; D029802:Croton / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D016325:HIV Long Terminal Repeat / Q000235:genetics; D006801:Humans; D008156:Luciferases / Q000378:metabolism; D015394:Molecular Structure; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
chemical_list: D004224:Diterpenes; D016328:NF-kappa B; D010936:Plant Extracts; D012717:Sesquiterpenes; D014409:Tumor Necrosis Factor-alpha; C503654:prenylbisabolane; D008156:Luciferases