Beta-lactam compounds as apparently uncompetitive inhibitors of HIV-1 protease.
Compounds of a combinatorial monocyclic beta-lactam library were found to be apparently uncompetitive inhibitors of HIV-1 protease, providing lead compounds for a new class of HIV protease inhibitors.
Sperka
Tamás
T
Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Faculty of Medicine, H-4012 Debrecen, Hungary.
Pitlik
János
J
Bagossi
Péter
P
Tözsér
József
J
D000818:Animals; D001667:Binding, Competitive; D020650:Combinatorial Chemistry Techniques; D019281:Dimerization; D015195:Drug Design; D016333:HIV Protease / Q000737:chemistry* / Q000378:metabolism; D017320:HIV Protease Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D009052:Leukemia Virus, Murine / Q000187:drug effects / Q000201:enzymology; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure; D019151:Peptide Library; D013329:Structure-Activity Relationship; D047090:beta-Lactams / Q000737:chemistry* / Q000494:pharmacology*
D017320:HIV Protease Inhibitors; D019151:Peptide Library; D047090:beta-Lactams; D016333:HIV Protease