title: Inflammatory myofibroblastic tumor in the larynx: clinicopathologic features and histogenesis.
abstract: Inflammatory myofibroblastic tumor is extremely rare in the larynx and can mimic a malignant process. We present the case of a 62-year-old male who required tracheotomy due to rapidly progressive stridor. Laryngoscopy showed an exophytic, occlusive tumor located in the right true vocal cord. CT showed an expansive mass measuring 2 x2 x1.3 cm3 and occupying the anterior commissure, with glottic progression to the right true vocal cord. The tumor was completely resected with a CO2 laser via a transoral approach. Histologic examination demonstrated extensive ulceration with the presence of granulation tissue. The specimen was mainly composed of spindle cells arranged in a fasciculated pattern with a myxoid background and focal hyalinization. Immunohistochemical studies revealed positivity of spindle cells to vimentin, muscle-specific actin and smooth muscle actin. The patient showed no evidence of disease 24 months after surgery.
authors.affiliation: Department of Otorhinolaryngology, Hospital Clinic, Barcelona, Barcelona ES-08036, Spain. 33785jgt@comb.es
authors.forename: Jose Maria
authors.initials: JM
authors.lastname: Guilemany
authors.forename: Llucia
authors.initials: L
authors.lastname: Alós
authors.forename: Isam
authors.initials: I
authors.lastname: Alobid
authors.forename: Manuel
authors.initials: M
authors.lastname: Bernal-Sprekelsen
authors.forename: Antonio
authors.initials: A
authors.lastname: Cardesa
mesh_terms: D006801:Humans; D007822:Laryngeal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D053685:Laser Therapy / Q000379:methods; D008297:Male; D008875:Middle Aged; D009379:Neoplasms, Muscle Tissue / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014140:Tracheotomy