New antibiotic Sch 725424 and its dehydration product Sch 725428 from Kitasatospora sp.
A new microbial metabolite Sch 725424 (1) was isolated from the culture of Kitasatospora sp. The structure elucidation of 1 was accomplished based on NMR spectroscopic analyses as well as extensive structure elucidation of its dehydration product Sch 725428 (2). Compound 1 showed inhibitory activity against Staphylococcus aureus with MIC values 1-2 microg/ml, and also displayed weak antifungal activity against Saccharomyces cerevisiae (PM503) with an MIC 32 microg/ml.
Yang
Shu-Wei
SW
Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. shu-wei.yang@spcorp.com
Chan
Tze-Ming
TM
Terracciano
Joseph
J
Patel
Reena
R
Loebenberg
David
D
Chen
Guodong
G
Patel
Mahesh
M
Gullo
Vincent
V
Pramanik
Birendra
B
Chu
Min
M
D000577:Amides / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D005285:Fermentation; D005663:Furans / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011090:Polyenes / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013306:Streptomycetaceae / Q000378:metabolism*
D000577:Amides; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D005663:Furans; D011090:Polyenes; C501238:Sch 725424; C501239:Sch 725428