Imaging with radiolabelled monoclonal antibody (MUJ591) to prostate-specific membrane antigen in staging of clinically localized prostatic carcinoma: comparison with clinical, surgical and histological staging.
OBJECTIVE
To evaluate the reliability of prostate scintigraphy using a radiolabelled antibody (MUJ591) raised against the external domain of prostate-specific membrane antigen (PSMA) in the staging of early prostate cancer.


METHODS
This was a prospective study of 16 patients who had radical retropubic prostatectomies (median PSA 9.75 ng/mL). All patients underwent PSMA imaging using MUJ591 radiolabelled with (99m)Tc using a photo-reduction technique.


RESULTS
The findings of prostate imaging and histology were identical in seven patients. Scans showed understaging and overstaging in six and three patients, respectively.


CONCLUSIONS
PSMA scintigraphy using (99m)Tc-labelled MUJ591 identifies the presence of prostate cancer, but is not sensitive in delineating micro-invasion of the capsule, seminal vesicles or bladder neck. As in other studies it seems to be useful in detecting prostate bed recurrence and distant micrometastasis.
Nargund
Vinod
V
Department of Urology, St Bartholomew's Hospital and Barts and the London Queen Mary School of Medicine and Dentistry, University of London, London, UK. vinod.nargund@bartsandthelondon. nhs.uk
Al Hashmi
Dona
D
Kumar
Priya
P
Gordon
Stephen
S
Otitie
Ugo
U
Ellison
David
D
Carroll
Melvyn
M
Baithun
Sohail
S
Britton
Keith E
KE
D000368:Aged; D000911:Antibodies, Monoclonal / Q000528:radiation effects; D000954:Antigens, Surface / Q000276:immunology*; D043425:Glutamate Carboxypeptidase II / Q000276:immunology*; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods*; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013667:Technetium; D015021:Yttrium Radioisotopes
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D015021:Yttrium Radioisotopes; D013667:Technetium; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II