title: Pufferfish and zebrafish have five distinct NPY receptor subtypes, but have lost appetite receptors Y1 and Y5.
abstract: The two neuropeptide Y (NPY) receptors Y1 and Y5 stimulate feeding in mammals, but are missing in the euteleosts, zebrafish and pufferfish (Takifugu rubripes). Both species have five other subtypes called Y2, Y7, Ya, Yb, and Yc. RT-PCR studies in pufferfish show that all five are expressed in the brain and may mediate NPY effects on feeding. Y2, Ya, and Yb are also broadly expressed in peripheral organs. These results reveal interesting differences in the NPY system of teleosts and mammals that may have arisen in the genetic turmoil involving the basal ray-fin fish tetraploidization.
authors.affiliation: Department of Neuroscience, Uppsala University, Sweden.
authors.forename: Tomas A
authors.initials: TA
authors.lastname: Larsson
authors.forename: Frida
authors.initials: F
authors.lastname: Olsson
authors.forename: Görel
authors.initials: G
authors.lastname: Sundström
authors.forename: Sydney
authors.initials: S
authors.lastname: Brenner
authors.forename: Byrappa
authors.initials: B
authors.lastname: Venkatesh
authors.forename: Dan
authors.initials: D
authors.lastname: Larhammar
mesh_terms: D000818:Animals; D001069:Appetite Regulation / Q000235:genetics; D006801:Humans; D017476:Receptors, Neuropeptide Y / Q000172:deficiency* / Q000235:genetics*; D023721:Tetraodontiformes / Q000235:genetics / Q000502:physiology*; D015027:Zebrafish / Q000235:genetics / Q000502:physiology*
chemical_list: D017476:Receptors, Neuropeptide Y; C097212:neuropeptide Y-Y1 receptor; C100568:neuropeptide Y5 receptor