title: Anticonvulsant activity and tolerance of ELB138 in dogs with epilepsy: a clinical pilot study.
abstract: A new antiepileptic and anxiolytic drug, ELB138, was evaluated in a clinical pilot study in dogs with newly diagnosed or chronic idiopathic epilepsy. The purpose was to verify clinically the anticonvulsant effectiveness of this substance, which had already been demonstrated experimentally. Data from 29 dogs treated with ELB138 were compared with results obtained retrospectively from 82 dogs treated with conventional antiepileptic medication. The reduction in seizure frequency using ELB138 in dogs with newly diagnosed idiopathic epilepsy was comparable to the reduction in dogs treated either with phenobarbital or primidone. In dogs with chronic epilepsy and add-on therapy with either ELB138 or potassium bromide, such supplementation reduced the seizure frequency and the duration and severity of seizures. The most obvious difference between ELB138 treatment and conventional medications became clear in the evaluation of side effects, which in those dogs treated with ELB138 were rare, and consisted mostly of transient polyphagia. This pilot study confirmed that ELB138 has a potent anticonvulsant effect in dogs with idiopathic epilepsy. These results will form the basis for a multicentre, blinded study.
authors.affiliation: Department of Small Animal Medicine and Surgery, University of Veterinary Medicine, and Center for Systems Neuroscience, Hannover, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Rieck
authors.forename: Chris
authors.initials: C
authors.lastname: Rundfeldt
authors.forename: Andrea
authors.initials: A
authors.lastname: Tipold
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D007093:Imidazoles / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D010865:Pilot Projects; D012008:Recurrence; D012640:Seizures / Q000453:epidemiology / Q000517:prevention & control / Q000662:veterinary*; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: C116306:AWD 131-138; D000927:Anticonvulsants; D007093:Imidazoles