title: Significance of ligature technique on the formation of pulmonary artery stump thrombosis in a canine model.
abstract: BACKGROUND
  Thrombo-embolism following pulmonary resection is a serious complication with a fatal outcome. We have tried to clarify the role of ligature techniques used in pulmonary resection on the formation of pulmonary artery stump thrombosis, which may lead to a subsequent pulmonary thrombo-embolism.
  
  
  METHODS
  Two groups of 10 mongrel dogs underwent a standard left pneumonectomy under anesthesia. The transfixation, or the continuous ligature technique, was applied to close the pulmonary artery stump in each group. Morphological evaluation of the ligated pulmonary artery was carried out, including the macroscopic thrombus formation and microscopic findings.
  
  
  RESULTS
  The transfixation ligature technique showed a significantly greater incidence of macroscopic thrombosis in the pulmonary artery stump when compared with the continuous ligature technique (p = 0.033). This was confirmed by microscopic changes (p = 0.020).
  
  
  CONCLUSIONS
  Thrombus formation in the pulmonary artery stump is more likely to occur following the closure of the stump with the transfixation ligature technique compared with the continuous ligature technique.
authors.affiliation: Department of Thoracic Surgery, Van Yuzuncuyil University.
authors.forename: F
authors.initials: F
authors.lastname: Işik
authors.forename: M
authors.initials: M
authors.lastname: Kara
authors.forename: B
authors.initials: B
authors.lastname: Tunçögür
authors.forename: S Dizbay
authors.initials: SD
authors.lastname: Sak
authors.forename: S
authors.initials: S
authors.lastname: Kavukçu
mesh_terms: D000818:Animals; D001707:Biopsy, Needle; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry; D008026:Ligation / Q000379:methods; D008297:Male; D011013:Pneumonectomy / Q000009:adverse effects* / Q000379:methods; D011336:Probability; D011651:Pulmonary Artery / Q000473:pathology / Q000601:surgery*; D011655:Pulmonary Embolism / Q000209:etiology / Q000601:surgery*; D011897:Random Allocation; D012680:Sensitivity and Specificity; D013536:Suture Techniques