Oxidative cascades: a facile biosynthetic strategy for the assembly of complex molecules.
Electron-rich aromatic compounds undergo a facile tandem reaction sequence involving an iterative two-electron oxidation/aromatization. This review will describe the application of this motif to the synthesis of dimethylbenzimidazole, pyoverdine, actinomycin, cystodytin, pyrroloquinoline quinone, and the cataract pigment.
Dorrestein
Pieter
P
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
Begley
Tadhg P
TP
D001562:Benzimidazoles / Q000737:chemistry / Q000378:metabolism; D002384:Catalysis; D003609:Dactinomycin / Q000096:biosynthesis / Q000737:chemistry; D004583:Electrons; D004798:Enzymes / Q000737:chemistry / Q000378:metabolism; D006841:Hydrocarbons, Aromatic / Q000737:chemistry / Q000378:metabolism*; D008024:Ligands; D008968:Molecular Conformation; D009842:Oligopeptides / Q000096:biosynthesis / Q000737:chemistry; D010084:Oxidation-Reduction; D010860:Pigments, Biological / Q000096:biosynthesis / Q000737:chemistry; D011809:Quinones / Q000737:chemistry / Q000378:metabolism
D001562:Benzimidazoles; D004798:Enzymes; D006841:Hydrocarbons, Aromatic; D008024:Ligands; D009842:Oligopeptides; D010860:Pigments, Biological; D011809:Quinones; D003609:Dactinomycin; C042453:pyoverdin