title: [Myocardial protective effects of pretreatment with captopril on ischemia-reperfusion myocardium in rabbits].
abstract: OBJECTIVE
  To investigate the effect of pretreatment with captopril on myocardium ischemia-reperfusion injury in atherosclerotic rabbits.
  
  
  METHODS
  Thirty-two New Zealand white rabbits were assigned randomly to the normally feed group, cholesterol-feed (CF) group, and cholesterol food plus captopril group (cap-feed group), which were fed for 10 weeks. We examined the changes in the size of the infarct and changes in the myocardium ultrastructure resulting from coronary ischemia/reperfusion. Levels of endothelin (ET) and nitic oxide (NO) were measured in the different experiment stages.
  
  
  RESULTS
  The ET levels significantly increased and the content of NO significantly decreased in the CF group compared with those of the cap-feed group. The ultrastructure of myocardium cell was slightly destroyed and the infarct size was significantly smaller in the cap-feed group than the normally feed rabbits and CF rabbits.
  
  
  CONCLUSIONS
  The long-term captopril treatment can lighten the severity of myocardial injury produced by coronary ischemia/reperfusion.
authors.affiliation: Department of Cardiothoracic Surgery, Second Xiangya Hospital ,Central South University , Changsha 410011, China. humingsong1973@hotmail.com
authors.forename: Ming-song
authors.initials: MS
authors.lastname: Hu
authors.forename: Jian-guo
authors.initials: JG
authors.lastname: Hu
authors.forename: Xin-min
authors.initials: XM
authors.lastname: Zhou
authors.forename: Yao-guang
authors.initials: YG
authors.lastname: Feng
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Jin-fu
authors.initials: JF
authors.lastname: Yang
mesh_terms: D000818:Animals; D002216:Captopril / Q000494:pharmacology / Q000627:therapeutic use*; D016232:Endothelins / Q000097:blood; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy*; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D009206:Myocardium / Q000648:ultrastructure; D009569:Nitric Oxide / Q000097:blood; D011817:Rabbits; D011897:Random Allocation
chemical_list: D016232:Endothelins; D009569:Nitric Oxide; D002216:Captopril