Cellular parameters for track structure modeling of radiation hazard in space.
Based on irradiation with 45 MeV/u N and B ions and with Co-60 gamma rays, cellular parameters of Katz's track structure model have been fitted for the survival of V79-379A Chinese hamster lung fibroblasts. Cellular parameters representing neoplastic transformations in C3H10T/1/2 cells after their irradiation with heavy ion beams, taken from earlier work, were also used to model the radiation hazard in deep space, following the system for evaluating, summing and reporting occupational exposures proposed in 1967 by a subcommittee of NCRP. We have performed model calculations of the number of transformations in surviving cells, after a given fluence of heavy charged particles of initial energy 500 MeV/u, penetrating thick layers of cells. We take the product of cell transformation and survival probabilities, calculated along the path lengths of charged particles using cellular survival and transformation parameters, to represent a quantity proportional to the "radiation risk factor" discussed in the NCRP document. The "synergistic" effect of simultaneous charged particle transfers is accounted for by the "track overlap" mode inherent in the model of Katz.
Waligórski
M P R
MP
Center of Oncology, Kraków, Poland. z5waligo@cyf-kr.edu.pl
Hollmark
M
M
Lind
B
B
Gudowska
I
I
D000818:Animals; D002244:Carbon; D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects*; D002471:Cell Transformation, Neoplastic / Q000528:radiation effects*; D003359:Cosmic Radiation; D006224:Cricetinae; D003412:Cricetulus; D004307:Dose-Response Relationship, Radiation; D005118:Extraterrestrial Environment; D005347:Fibroblasts; D020450:Heavy Ions; D006859:Hydrogen; D007501:Iron; D018499:Linear Energy Transfer; D008168:Lung / Q000166:cytology / Q000528:radiation effects; D008954:Models, Biological; D009686:Nuclear Physics; D014501:Uranium
D014501:Uranium; D002244:Carbon; D006859:Hydrogen; D007501:Iron