[Regulatory-adaptive abilities of hypertensive patients treated with lisinopril and atenolol].
OBJECTIVE
To examine regulatory-adaptive possibilities of hypertensive patients treated with lisinopril and atenolol.


METHODS
Monotherapies with lisinopril and atenolol were compared in relation to effect on arterial pressure and parameters of cardiac-respiratory synchronism after a single and 5-week intake in 37 patients.


RESULTS
Lisinopril increased in 19 patients the range of synchronization by 28.5% (p < 0.05) after a single dose and by 40% (p < 0.001) after 5-week treatment. Atenolol had an adequate hypotensive effect in 18 patients but promoted a decrease of range sychnonization by 41% (p < 0.00001) after a single intake.


CONCLUSIONS
Hypotensive drugs should be studied for effects on regulatory-adaptive ability of the organism.
D000222:Adaptation, Physiological; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001262:Atenolol / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D017706:Lisinopril / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
D000959:Antihypertensive Agents; D001262:Atenolol; D017706:Lisinopril