title: Synthesis, spectroscopic and biological properties of bis(3-arylimidazolidinyl-1)methanes. A novel family of antimicrobial agents.
abstract: Synthesis, spectroscopic and biological properties of new bis(3-arylimidazolidinyl-1)methanes are described. These compounds were synthesized by condensation reaction between N-arylethylenediamines and formaldehyde. Chemical structures were confirmed by means of their (1)H- and (13)C-NMR and mass spectroscopic data. Investigation of in vitro antimicrobial activity was performed using Gram-negative and Gram-positive bacteria as well as antifungal studies against Aspergillus niger and Candida albicans. Minimal inhibitory concentrations of active compounds were determined.
authors.affiliation: Department of Organic Chemistry, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Junín 956 (1113) Buenos Aires, Argentina. iperillo@ffyb.uba.ar
authors.forename: Isabel
authors.initials: I
authors.lastname: Perillo
authors.forename: Evangelina
authors.initials: E
authors.lastname: Repetto
authors.forename: María Cristina
authors.initials: MC
authors.lastname: Caterina
authors.forename: Rosana
authors.initials: R
authors.lastname: Massa
authors.forename: Gabriel
authors.initials: G
authors.lastname: Gutkind
authors.forename: Alejandra
authors.initials: A
authors.lastname: Salerno
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005029:Ethylenediamines / Q000737:chemistry; D005557:Formaldehyde / Q000737:chemistry; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D005029:Ethylenediamines; D007093:Imidazoles; D005557:Formaldehyde; D008697:Methane