Plasma free amino acid profile in cancer patients.
Redistribution or translocation of plasma free amino acids (PFAAs) to support visceral or tumor protein synthesis is an essential feature in cancer patients. An abnormal PFAA profile might be presented via the total reflection of cancer-induced protein metabolism in tumors, skeletal muscle and the liver in cancer patients. Clinical data from 13 studies have demonstrated a cancer-related PFAA profile, especially in digestive organ cancers. The PFAA profile can differ between the early and late stages of cancer. The profile is also affected by the type of cancer. Therefore, it is postulated that a detailed analysis of the PFAA profile may serve as one of the biological markers for cancer patients.
Lai
Hong-Shiee
HS
Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Lee
Jenq-Chang
JC
Lee
Po-Huang
PH
Wang
Shan-Tair
ST
Chen
Wei-Jao
WJ
D000596:Amino Acids / Q000097:blood*; D006801:Humans; D009369:Neoplasms / Q000097:blood* / Q000473:pathology
D000596:Amino Acids