Properties of neurons in the trigeminal nucleus caudalis responding to noxious dural and facial stimulation.
Extracellular single unit recordings were made in the rat trigeminal nucleus caudalis (Vc) from cells with Adelta and C-fibre latency responding to electrical stimulation of the thinned cranium overlying the middle meningeal artery (MMA). The neurons had an ipsilateral facial receptive field (FRF) that mainly extended over areas innervated by the first and second division of the trigeminal nerve but in some cases also included areas innervated by the third division of the trigeminal nerve. No wind-up of either long latency C-fibre or short latency Adelta responses was seen during trains of electrical stimulation. Sensitisation of mechanical stimulation of the FRF could also not be observed at any time during dural stimulation. In contrast, extracellular single unit recordings in the Vc activated by electrical stimulation of the facial skin resulted in a significant wind-up response of long latency response in six of ten cells studied. The facial-elicited wind-up response was significantly enhanced, 18 min after the electrical stimulation protocol was started, indicating that the process of wind-up had generated central excitability. The findings in this study demonstrate a clear difference between the effects of electrical stimulation of cutaneous and non-cutaneous inputs. In the trigeminal system, this has implications for the study of pathways such as those involved in headache, where it is believed that an enhanced dural input to the Vc may generate central sensitisation and partly explain the hyperalgesia and allodynia reported by patients.
Bolton
S
S
Headache Group, Institute of Neurology, London, UK.
O'Shaughnessy
C T
CT
Goadsby
P J
PJ
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D004388:Dura Mater / Q000502:physiology*; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000502:physiology; D005145:Face / Q000294:innervation / Q000502:physiology*; D008297:Male; D036421:Nerve Fibers, Unmyelinated / Q000145:classification / Q000502:physiology; D009475:Neurons, Afferent / Q000145:classification / Q000502:physiology*; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011984:Sensory Receptor Cells / Q000502:physiology; D012867:Skin / Q000294:innervation; D014275:Trigeminal Caudal Nucleus / Q000166:cytology / Q000502:physiology*; D014276:Trigeminal Nerve / Q000166:cytology / Q000502:physiology