[Ultrasound-mediated gene delivery].
Recently there have been increasing interests in ultrasound-mediated gene delivery techniques. This paper reviews the general concept of sonoporation, the effect of contrast agents, and the in vitro and in vivo applications of such techniques. Factors which contribute to the efficiency of gene delivery were also discussed. The technology is promising and has great potential in targeted drug delivery and gene delivery applications.
He
Wei
W
College of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai 200030, China.
Liu
Rui
R
Chen
Yazhu
Y
Xu
Yuhong
Y
D004247:DNA / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D018014:Gene Transfer Techniques / Q000295:instrumentation*; D015316:Genetic Therapy; D006801:Humans; D045423:Microbubbles; D014162:Transfection / Q000379:methods; D014464:Ultrasonic Therapy / Q000379:methods; D014465:Ultrasonics
D004247:DNA