Toxoplasma gondii-like organisms in skin aspirates from a cat with disseminated protozoal infection.
An 8-year-old, male domestic shorthair cat was referred to the Matthew J. Ryan Veterinary Hospital of the University of Pennsylvania with a 3-day history of lethargy, inappetance, hyperemic skin nodules, coughing, and vomiting. Laboratory results included nonregenerative anemia, lymphopenia, thrombocytopenia, hypoalbuminemia, hyponatremia, and increased alanine aminotransferase and aspartate aminotransferase activities. Cytology of the skin nodules revealed many spindle- to crescent-shaped protozoal organisms, with morphology consistent with Toxoplasma gondii or Neospora caninum. Gross necropsy, histopathologic, immunohistochemical, and transmission electron microscopic findings confirmed a systemic protozoal infection; however, the organism exhibited characteristics of both N caninum and T gondii. Diagnosis of a T gondii-like infection was based on internal structures of the organism and positive reaction to rabbit polyclonal antibodies to T gondii. Reports of toxoplasmic dermatitis are rare in the cat and dog, and this is the first reported diagnosis of T gondii-like protozoa in skin aspirates.
Little
Liz
L
Department of Pathobiology, Laboratory of Pathology and Toxicology, University of Pennsylvania, Philadelphia, PA, USA. lizklittle@yahoo.com
Shokek
Amy
A
Dubey
J P
JP
Deheer
Heather Leigh
HL
D000818:Animals; D002371:Cat Diseases / Q000469:parasitology*; D002415:Cats; D008168:Lung / Q000469:parasitology; D008297:Male; D012867:Skin / Q000469:parasitology / Q000648:ultrastructure; D012876:Skin Diseases, Parasitic / Q000469:parasitology / Q000662:veterinary*; D014124:Toxoplasmosis, Animal / Q000469:parasitology*