Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection.
Chronic granulomatous disease (CGD) is characterized by life-threatening bacterial and fungal infections. Treatment with posaconazole led to a complete response in 7 of 8 patients with CGD with invasive mold infections (7 proven cases and 1 possible case) after failure or intolerance of treatment with standard antifungal agents. In this preliminary study, salvage treatment with posaconazole was safe and effective.
Segal
Brahm H
BH
Department of Medicine, Division of Infectious Diseases, Roswell Park Cancer Institute, Buffalo, NY, USA.
Barnhart
Lisa A
LA
Anderson
Victoria L
VL
Walsh
Thomas J
TJ
Malech
Harry L
HL
Holland
Steven M
SM
D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D002648:Child; D005260:Female; D005658:Fungi / Q000302:isolation & purification* / Q000472:pathogenicity; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000150:complications* / Q000188:drug therapy* / Q000235:genetics / Q000382:microbiology; D008297:Male; D016879:Salvage Therapy; D014230:Triazoles / Q000627:therapeutic use*
D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole