Human cytomegalovirus downregulates complement receptors (CR3, CR4) and decreases phagocytosis by macrophages.
Human cytomegalovirus (HCMV) infection is associated with an increased susceptibility to opportunistic infections. Although the subversion of adaptive immune responses has been extensively studied, the consequences of HCMV infection on natural immune responses are not well documented. A striking selective downmodulation of CD11b/CD18 (CR3) or CD11c/CD18 (CR4) was found upon HCMV infection, on two models, the monocytic THP-1 cell line and monocyte- derived macrophages. HCMV-infected macrophages have an altered adhesion/phagocytic capacity to Candida albicans, a pathogen responsible for some opportunistic infections in immunocompromised patients. These results suggest a new mechanism implicated in the augmentation of opportunistic infections in HCMV patients.
Gafa
Valerie
V
Laboratoire Interactions Cellulaires Parasites-Hôte (ICPH) UJF EA-2940, Faculté de Médecine-Pharmacie, Domaine de la Merci, La Tronche, France.
Manches
Olivier
O
Pastor
Alexandrine
A
Drouet
Emmanuel
E
Ambroise-Thomas
Pierre
P
Grillot
Renee
R
Aldebert
Delphine
D
D002176:Candida albicans / Q000276:immunology; D002460:Cell Line; D003587:Cytomegalovirus / Q000276:immunology*; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate; D016167:Integrin alphaXbeta2 / Q000096:biosynthesis*; D016177:Macrophage-1 Antigen / Q000096:biosynthesis*; D008264:Macrophages / Q000276:immunology* / Q000821:virology; D010587:Phagocytosis
D016167:Integrin alphaXbeta2; D016177:Macrophage-1 Antigen