ETV6 gene rearrangements in invasive breast carcinoma.
The ETV6/TEL gene encodes a transcription factor frequently rearranged in several types of cancer. We looked for ETV6 rearrangements in invasive breast cancer using fluorescence in situ hybridization (FISH) of BAC probes on sections of tissue microarrays containing 632 tumor samples. Of these samples, signal of sufficient quality for screening by FISH was obtained for 356. Five cases (one lobular, one nontypical secretory, one mixed, and two ductal carcinomas) showed ETV6 rearrangement.
Letessier
Anne
A
Marseille Cancer Institute, Laboratory of Molecular Oncology, Institut Paoli-Calmettes and UMR599 Inserm, Marseille, France.
Ginestier
Christophe
C
Charafe-Jauffret
Emmanuelle
E
Cervera
Nathalie
N
Adélaïde
José
J
Gelsi-Boyer
Véronique
V
Ahomadegbe
Jean-Charles
JC
Benard
Jean
J
Jacquemier
Jocelyne
J
Birnbaum
Daniel
D
Chaffanet
Max
M
D000230:Adenocarcinoma / Q000235:genetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019677:Artificial Gene Fusion; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002503:Centromere / Q000235:genetics; D002874:Chromosome Mapping; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009687:Nuclear Proteins / Q000235:genetics*; D050783:Proto-Oncogene Proteins c-ets; D012097:Repressor Proteins / Q000235:genetics*; D016615:Telomere / Q000235:genetics; D000097764:ETS Translocation Variant 6 Protein
D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D050783:Proto-Oncogene Proteins c-ets; D012097:Repressor Proteins; D000097764:ETS Translocation Variant 6 Protein