title: Anterior capsular staining with trypan blue for capsulorhexis in mature and hypermature cataracts. A preliminary study.
abstract: OBJECTIVE
  To study the efficacy and safety of 0.1% Trypan Blue dye to stain the anterior capsule for capsulorhexis in mature and hypermature cataracts.
  
  
  METHODS
  This preliminary study included 25 eyes of 25 patients with a unilateral mature or hypermature cataract, including one case of traumatic mature cataract. In all these cases 0.2 ml of 0.1% trypan blue dye was used to stain the anterior capsule. The efficacy and safety of the dye was evaluated on the basis of intraoperative and postoperative observations.
  
  
  RESULTS
  In all 25 eyes the capsulorhexis was completed. There was peripheral extension of the capsulorhexis in the eye with traumatic cataract and the stained edge of the anterior capsule helped identification and redirection of the capsulorhexis. Successful phacoemulsification with intraocular lens implantation was performed in all eyes. Adverse reactions related to the dye such as raised intraocular pressure, anterior chamber inflammation and endothelial damage were not observed in the immediate postoperative period or at the end of mean follow-up of 3 months.
  
  
  CONCLUSIONS
  Trypan blue dye staining of the anterior capsule appears to be a very useful and safe technique that simplifies capsulorhexis in mature and hypermature cataracts.
authors.affiliation: Bombay City Eye Institute, Mumbai, India. eyecare@bombaycityeye.org
authors.forename: K
authors.initials: K
authors.lastname: Kothari
authors.forename: S S
authors.initials: SS
authors.lastname: Jain
authors.forename: N J
authors.initials: NJ
authors.lastname: Shah
mesh_terms: D000328:Adult; D000368:Aged; D019923:Capsulorhexis / Q000379:methods*; D002386:Cataract / Q000473:pathology*; D004396:Coloring Agents; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care / Q000379:methods; D011446:Prospective Studies; D012449:Safety; D013194:Staining and Labeling / Q000379:methods*; D016896:Treatment Outcome; D014343:Trypan Blue
chemical_list: D004396:Coloring Agents; D014343:Trypan Blue