title: Effect of low-dose, short-duration creatine supplementation on anaerobic exercise performance.
abstract: To examine the efficacy of a low-dose, short-duration creatine monohydrate supplement, 40 physically active men were randomly assigned to either a placebo or creatine supplementation group (6 g of creatine monohydrate per day). Testing occurred before and at the end of 6 days of supplementation. During each testing session, subjects performed three 15-second Wingate anaerobic power tests. No significant (p > 0.05) group or time differences were observed in body mass, peak power, mean power, or total work. In addition, no significant (p > 0.05) differences were observed in peak power, mean power, or total work. However, the change in the rate of fatigue of total work was significantly (p < 0.05) lower in the creatine supplementation group than in the placebo group, indicating a reduced fatigue rate in subjects supplementing with creatine compared with the placebo. Although the results of this study demonstrated reduced fatigue rates in patients during high-intensity sprint intervals, further research is necessary in examining the efficacy of low-dose, short-term creatine supplementation.
authors.affiliation: Department of Health and Exercise Science, The College of New Jersey, Ewing, New Jersey 08628, USA. Hoffmanj@tcnj.edu
authors.forename: Jay R
authors.initials: JR
authors.lastname: Hoffman
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Stout
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Falvo
authors.forename: Jie
authors.initials: J
authors.lastname: Kang
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Ratamess
mesh_terms: D000328:Adult; D015308:Anaerobic Threshold / Q000187:drug effects* / Q000502:physiology; D019540:Area Under Curve; D003401:Creatine / Q000008:administration & dosage*; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D018763:Muscle Fatigue / Q000187:drug effects / Q000502:physiology; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology; D012420:Running / Q000502:physiology; D013647:Task Performance and Analysis; D016896:Treatment Outcome
chemical_list: D003401:Creatine