title: Syntheses of chlorogenin 6alpha-O-acyl-3-O-beta-chacotriosides and their antitumor activities.
abstract: Chlorogenin 3-O-beta-chacotrioside (1) and its 6alpha-O-acyl derivatives (2-6) were concisely synthesized. Introduction of a hydroxyl or acyloxy group onto the C-6 of the steroidal aglycone of dioscin decreased significantly the cytotoxicity of the parent saponin (dioscin).
authors.affiliation: Key Laboratory of Marine Drugs, Ministry of Education, Marine Drug and Food Institute, Ocean University of China, Qingdao.
authors.forename: Yichun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yingxia
authors.initials: Y
authors.lastname: Li
authors.forename: Tiantian
authors.initials: T
authors.lastname: Guo
authors.forename: Huashi
authors.initials: H
authors.lastname: Guan
authors.forename: Jiwei
authors.initials: J
authors.lastname: Shi
authors.forename: Qiang
authors.initials: Q
authors.lastname: Yu
authors.forename: Biao
authors.initials: B
authors.lastname: Yu
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D008969:Molecular Sequence Data; D015394:Molecular Structure; D012503:Saponins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D012503:Saponins