Aripiprazole (abilify) overdose in a child.
Aripiprazole, 7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl] butyloxy}-3,4-dihydro-2(1H)-quinolinone, is an atypical antipsychotic medication inaugurating the newest class of atypical antipsychotics: the partial dopamine agonists. It has a particularly long half-life of elimination and variable metabolism secondary to genetic polymorphism. We report an unintentional overdose of 195 mg (17.1 mg/kg) of aripiprazole in a 2.5 year-old child. This patient exhibited CNS depression not requiring respiratory support and without significant cardiovascular effects. CNS effects persisted for almost 2 weeks postingestion.
Seifert
Steven A
SA
Nebraska Regional Poison Center, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Schwartz
Michael D
MD
Thomas
Jerry D
JD
D014150:Antipsychotic Agents / Q000506:poisoning*; D000068180:Aripiprazole; D002675:Child, Preschool; D062787:Drug Overdose; D005260:Female; D006801:Humans; D010879:Piperazines / Q000506:poisoning*; D015363:Quinolones / Q000506:poisoning*; D016896:Treatment Outcome; D014474:Unconsciousness / Q000209:etiology* / Q000503:physiopathology
D014150:Antipsychotic Agents; D010879:Piperazines; D015363:Quinolones; D000068180:Aripiprazole