title: New antibiotic Sch 725424 and its dehydration product Sch 725428 from Kitasatospora sp.
abstract: A new microbial metabolite Sch 725424 (1) was isolated from the culture of Kitasatospora sp. The structure elucidation of 1 was accomplished based on NMR spectroscopic analyses as well as extensive structure elucidation of its dehydration product Sch 725428 (2). Compound 1 showed inhibitory activity against Staphylococcus aureus with MIC values 1-2 microg/ml, and also displayed weak antifungal activity against Saccharomyces cerevisiae (PM503) with an MIC 32 microg/ml.
authors.affiliation: Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. shu-wei.yang@spcorp.com
authors.forename: Shu-Wei
authors.initials: SW
authors.lastname: Yang
authors.forename: Tze-Ming
authors.initials: TM
authors.lastname: Chan
authors.forename: Joseph
authors.initials: J
authors.lastname: Terracciano
authors.forename: Reena
authors.initials: R
authors.lastname: Patel
authors.forename: David
authors.initials: D
authors.lastname: Loebenberg
authors.forename: Guodong
authors.initials: G
authors.lastname: Chen
authors.forename: Mahesh
authors.initials: M
authors.lastname: Patel
authors.forename: Vincent
authors.initials: V
authors.lastname: Gullo
authors.forename: Birendra
authors.initials: B
authors.lastname: Pramanik
authors.forename: Min
authors.initials: M
authors.lastname: Chu
mesh_terms: D000577:Amides / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D005285:Fermentation; D005663:Furans / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011090:Polyenes / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013306:Streptomycetaceae / Q000378:metabolism*
chemical_list: D000577:Amides; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D005663:Furans; D011090:Polyenes; C501238:Sch 725424; C501239:Sch 725428