title: Neonatal lupus erythematosus presenting with cholestatic hepatitis: a case report and review of the literature.
abstract: Neonatal lupus erythematosus (NLE) is a disease primarily characterized by cardiac and/or cutaneous involvement. Hepatic, hematological, neurological and pulmonary involvement are rare manifestations and normally considered as mild and transient complications. But recent studies have shown more frequent hepatic involvement in NLE. We report a two month-old male infant, born to a clinically asymptomatic mother, presenting with significant hepatic involvement and annular, erythematous plaques with hyperkeratotic borders at the eyebrow region and anterior surface of trunk. Both the infant and his mother were positive for anti-Ro (SS-A) and anti-La (SS-B).
authors.affiliation: Department of Pediatrics, Cukurova University Faculty of Medicine, Adana, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Erbey
authors.forename: Abdullah
authors.initials: A
authors.lastname: Cuhaci
authors.forename: Faruk
authors.initials: F
authors.lastname: Incecik
authors.forename: Aytül
authors.initials: A
authors.lastname: Noyan
authors.forename: Derya Ufuk
authors.initials: DU
authors.lastname: Altintaş
authors.forename: Ilhan
authors.initials: I
authors.lastname: Tuncer
authors.forename: Figen
authors.initials: F
authors.lastname: Duran
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000974:Antibodies, Antinuclear / Q000097:blood; D001663:Bilirubin / Q000097:blood; D002780:Cholestasis, Intrahepatic / Q000209:etiology*; D043384:Glutamyl Aminopeptidase / Q000097:blood; D006801:Humans; D017488:Hyperkeratosis, Epidermolytic / Q000097:blood; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D008297:Male; D011379:Prognosis; D013256:Steroids / Q000008:administration & dosage / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000974:Antibodies, Antinuclear; D013256:Steroids; D000410:Alanine Transaminase; D043384:Glutamyl Aminopeptidase; D001663:Bilirubin