title: Detection through screening of maternal thyrotoxicosis induced central hypothyroidism in newborns.
abstract: Use of a third generation TSH assay enabled extremely low values of TSH to be detected through newborn screening. The use of a supplemental free thyroxine improved testing specificity. The hypothyroidism observed is believed to be secondary to suppression of the hypothalamic-pituitary-thyroid axis by placentally transferred maternal thyroxine.
authors.affiliation: Department of Pediatrics, National University of Singapore.
authors.forename: Roy
authors.initials: R
authors.lastname: Joseph
authors.forename: Yung Seng
authors.initials: YS
authors.lastname: Lee
authors.forename: Steven Chin Yuen
authors.initials: SC
authors.lastname: Ng
authors.forename: Kah Yin
authors.initials: KY
authors.lastname: Loke
mesh_terms: D003409:Congenital Hypothyroidism; D005260:Female; D005312:Fetal Blood; D006403:Hematologic Tests; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis* / Q000209:etiology; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D015997:Neonatal Screening / Q000379:methods*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood; D012680:Sensitivity and Specificity; D013971:Thyrotoxicosis / Q000097:blood / Q000150:complications*; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000008:administration & dosage
chemical_list: D013972:Thyrotropin; D013974:Thyroxine