A putative nuclear function for mammalian Staufen.
In addition to its role in rRNA processing and ribosome assembly, the nucleolus plays a part in the assembly of non-ribosomal ribonucleoprotein particles (RNPs) that are destined for cytoplasmic RNA delivery. Recent evidence indicates that mammalian Staufen2, a brain-specific RNA-binding protein involved in RNA localization, can--at least transiently--enter the nucleolus. Therefore, the assembly of Staufen2 into transport-competent RNPs might occur in the nucleus before their export into the cytoplasm. This could provide new insights into the mechanisms of subcellular RNA localization.
Kiebler
Michael A
MA
Max-Planck-Institute for Developmental Biology, Spemannstrasse 35, D-72076, Tübingen, Germany.
Jansen
Ralf-Peter
RP
Dahm
Ralf
R
Macchi
Paolo
P
D021581:Active Transport, Cell Nucleus; D000243:Adenosine Deaminase / Q000378:metabolism; D000818:Animals; D002466:Cell Nucleolus / Q000378:metabolism*; D008954:Models, Biological; D020033:Protein Isoforms / Q000378:metabolism; D012313:RNA / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*; D012261:Ribonucleoproteins / Q000096:biosynthesis
D020033:Protein Isoforms; D016601:RNA-Binding Proteins; D012261:Ribonucleoproteins; C117884:staufen protein, mammalian; D012313:RNA; C567955:ADARB1 protein, human; D000243:Adenosine Deaminase