TP53 codon 72 polymorphism and risk for cervical cancer in Portugal.
High-risk human papillomavirus are essential for the development of cervical cancer; however, TP53 is the most frequently altered tumor suppressor gene among tumors and is described as a cofactor for cervical carcinogenesis. TP53 has two common polymorphic forms encoding either proline or arginine, at position 72, and the presence of homozygous arginine has been reported as a risk factor for cervical cancer in many populations. We evaluated the effect of this TP53 polymorphism in a northern Portuguese population. We analyzed blood samples of 385 women; 20 with low-grade squamous intraepithelial lesion (SIL), 56 with high-grade SIL, 164 with invasive cervical cancer, and 145 healthy controls, using allele specific-polymerase chain reaction methodology. We observed an increased frequency of the Arg/Arg genotype in the cancer group, but no statistical significance was found between cases and controls (P>0.05). Our results indicate that there is no association between the presence of the Arg allele in codon 72 of TP53 polymorphism and risk of cervical cancer in our population.
Santos
Alexandra M
AM
Molecular Oncology Unit, Portuguese Institute of Oncology-Porto, Laboratórios 4 Piso, Rua Dr. António Bernardino Almeida, 4200-072 Porto, Portugal.
Sousa
Hugo
H
Catarino
Raquel
R
Pinto
Daniela
D
Pereira
Deolinda
D
Vasconcelos
André
A
Matos
Ana
A
Lopes
Carlos
C
Medeiros
Rui
R
D003062:Codon; D005260:Female; D016158:Genes, p53; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011174:Portugal / Q000453:epidemiology; D012306:Risk; D002583:Uterine Cervical Neoplasms / Q000235:genetics*
D003062:Codon