title: [Clinical evaluation of 23 children with neuroblastoma. The experience of a single institution].
abstract: In this retrospective study, we analyse epidemiology, clinical symptoms and therapeutic results in a group of 23 children with neuroblastoma. Half of them were less than 2 years of age; in 19 of 23, the primitive tumour was abdominal; 35% of them were initially metastatic. The overall survival was 83% at 5 years and the event free survival, 75% at 5 years. Pronostic factors are age, extension of the disease at diagnosis, biologic parameters and genetic study of the neuroblast cells (amplification of N-myc oncogen). Our study shows the deleterious effect of bone lesions.
authors.affiliation: Ulg Aspirante FNRS.
authors.forename: C
authors.initials: C
authors.lastname: Piette
authors.forename: M F
authors.initials: MF
authors.lastname: Dresse
authors.forename: P
authors.initials: P
authors.lastname: Forget
authors.forename: V
authors.initials: V
authors.lastname: Schmitz
authors.forename: M
authors.initials: M
authors.lastname: Demarche
authors.forename: P
authors.initials: P
authors.lastname: Erpicum
authors.forename: M T
authors.initials: MT
authors.lastname: Closon
authors.forename: I
authors.initials: I
authors.lastname: Rutten
authors.forename: P
authors.initials: P
authors.lastname: Paulus
authors.forename: D
authors.initials: D
authors.lastname: Vivegnis
authors.forename: Y
authors.initials: Y
authors.lastname: Beguin
authors.forename: P
authors.initials: P
authors.lastname: Jamblin
authors.forename: Cl
authors.initials: C
authors.lastname: Hoyoux
mesh_terms: D000008:Abdominal Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009447:Neuroblastoma / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D012189:Retrospective Studies; D013899:Thoracic Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy