title: Occupational contact allergy to glyoxal.
abstract: Glyoxal is a dialdehyde that is used as a disinfectant in health care and dentistry work. Allergic contact dermatitis from glyoxal has been described in these occupations. We analysed our patient data from 1998 to 2004 for allergic reactions to glyoxal. 20 patients had allergic reactions to glyoxal on patch testing. 5 of these patients worked in dentistry and 4 of them had present exposure to glyoxal. 9 patients were machinists without obvious exposure to glyoxal. A grinder with work-related facial dermatitis is described in detail. The chemical analysis of air samples from his workplace revealed 9.4-21 microg/m3 glyoxal. Glyoxal was also present in the used metal-working fluid, and apparently it had been formed during grinding. The remaining 6 patients worked in miscellaneous occupations and had no present exposure to glyoxal. Glyoxal is irritant on patch testing. Especially, solitary reactions to glyoxal 10% in aq. may be false-positive irritant reactions. 9 (45%) of our patients reacted to formaldehyde or glutaraldehyde. Glyoxal is an important allergen in dentistry and medical care, and we recommend it to be added to the antimicrobial patch test series. It also seems to be a 'hidden' allergen in the metal industry.
authors.affiliation: Section of Dermatology, Finnish Institute of Occupational Health, Helsinki, Finland. kristiina.aalto-korte@ttl.fi
authors.forename: Kristiina
authors.initials: K
authors.lastname: Aalto-Korte
authors.forename: Erja A
authors.initials: EA
authors.lastname: Mäkelä
authors.forename: Maria
authors.initials: M
authors.lastname: Huttunen
authors.forename: Katri
authors.initials: K
authors.lastname: Suuronen
authors.forename: Riitta
authors.initials: R
authors.lastname: Jolanki
mesh_terms: D000328:Adult; D015331:Cohort Studies; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005387:Finland / Q000453:epidemiology; D006037:Glyoxal / Q000009:adverse effects* / Q000494:pharmacology; D006282:Health Personnel / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016272:Occupational Health; D010328:Patch Tests; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index
chemical_list: D006037:Glyoxal