title: Chronic cytomegalovirus infection and inflammation are associated with prevalent frailty in community-dwelling older women.
abstract: OBJECTIVE
  To evaluate the association between asymptomatic chronic cytomegalovirus (CMV) infection and the frailty syndrome and to assess whether inflammation modifies this association.
  
  
  METHODS
  Cross-sectional analysis.
  
  
  METHODS
  Women's Health and Aging Study I & II, Baltimore, Maryland.
  
  
  METHODS
  Seven hundred twenty-four community-dwelling women aged 70 to 79 with baseline measures of CMV, interleukin-6 (IL-6), and frailty status.
  
  
  METHODS
  CMV serology and IL-6 concentrations were measured using enzyme-linked immunosorbent assay. Frailty status was based on previously validated criteria: unintentional weight loss, weak grip strength, exhaustion, slow walking speed, and low level of activity. Frail women had three or more of the five components, prefrail women had one or two components, and women who were not frail had none of the components. Multinomial logistic regression adjusted for potential confounders.
  
  
  RESULTS
  Eighty-seven percent of women were CMV seropositive, an indication of chronic infection. CMV was associated with prevalent frailty, adjusting for age, smoking history, elevated body mass index, diabetes mellitus, and congestive heart failure (CMV frail adjusted odds ratio (AOR)=3.2, P=.03; CMV prefrail AOR=1.5, P=.18). IL-6 interacted with CMV, significantly increasing the magnitude of this association (CMV positive and low IL-6 frail AOR=1.5, P=.53; CMV positive and high IL-6 frail AOR=20.3, P=.007; CMV positive and low IL-6 prefrail AOR=0.9, P=.73; CMV positive and high IL-6 prefrail AOR=5.5, P=.001).
  
  
  CONCLUSIONS
  Chronic CMV infection is associated with prevalent frailty, a state with increased morbidity and mortality in older adults; inflammation enhances this effect. Further prospective studies are needed to establish a causal relationship between CMV, inflammation, and frailty.
authors.affiliation: Division of Geriatric Medicine, Department of Medicine, University of Calgary, Calgary, Alberta, Canada. heidi.schmaltz@calgaryhealthregion.ca
authors.forename: Heidi N
authors.initials: HN
authors.lastname: Schmaltz
authors.forename: Linda P
authors.initials: LP
authors.lastname: Fried
authors.forename: Qian-Li
authors.initials: QL
authors.lastname: Xue
authors.forename: Jeremy
authors.initials: J
authors.lastname: Walston
authors.forename: Sean X
authors.initials: SX
authors.lastname: Leng
authors.forename: Richard D
authors.initials: RD
authors.lastname: Semba
mesh_terms: D000368:Aged; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D003586:Cytomegalovirus Infections / Q000150:complications*; D004797:Enzyme-Linked Immunosorbent Assay; D016330:Frail Elderly; D006801:Humans; D007249:Inflammation / Q000150:complications*; D015850:Interleukin-6 / Q000097:blood; D012111:Residence Characteristics
chemical_list: D015850:Interleukin-6