[Cutaneous CD8+ squamous T-cell bullous lymphoma].
BACKGROUND
Bullous forms of cutaneous T-cell lymphomas are rare. A new group of cutaneous T-cell lymphomas has recently been identified as a distinct clinicopathological and immunophenotype entity. These cutaneous T-cell lymphomas express a CD8+ phenotype, rarely expressed in other cutaneous T-cell lymphomas.


METHODS
We describe a cutaneous CD8+ squamous T-cell lymphoma with polymorphic clinical features, strongly epidermotropic lymphoid infiltrate and spongiosis, classical for this type of lymphoma.


CONCLUSIONS
Bullous lesions in cutaneous T-cell lymphoma should evoke the possibility of a cutaneous CD8+ T-cell lymphoma, once other bullous diseases have been excluded. Spongiosis, rare in other types of T-cell lymphoma, and strongly epidermotropic pleomorphic lymphoid infiltrate are classical histological features. The association of polymorphic lesions, bullas and atypical CD8+ epidermotropic phenotype should evoke this diagnosis even at the early stage. Treatment is difficult and classical chemotherapy often fails. Prognosis is poor with a mean overall survival of 32 months.
Héliot-Hosten
I
I
Unité de Dermatologie Cancérologie, Hôpital Saint-André, CHU Bordeaux, Université Bordeaux 2 Victor Ségalen, Bordeaux. isabelle.heliot@chu-bordeaux.fr
Versapuech
J
J
Vergier
B
B
Taieb
A
A
Delaunay
M
M
D000368:Aged; D018414:CD8-Positive T-Lymphocytes; D017809:Fatal Outcome; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000473:pathology*; D008297:Male; D012878:Skin Neoplasms / Q000473:pathology*