title: Pimecrolimus for treatment of acne rosacea.
abstract: BACKGROUND
  Rosacea is a common disease, which is often resistant to treatment. Topical calcineurin inhibitors have been efficacious in the treatment of other inflammatory disorders of the skin, and tacrolimus has been reported as an effective treatment option for erythrotelangiectatic rosacea.
  
  
  OBJECTIVE
  Because of the benefits seen with tacrolimus in previous publications, we investigated the efficacy of a closely related compound, pimecrolimus, in patients with erythrotelangiectatic, papulopustular, and edematous rosacea.
  
  
  METHODS
  Twelve patients with erthryotelangiectatic or papulopustular rosacea who had failed conventional therapy were treated with topical pimecrolimus cream twice daily for 12-18 weeks. No patients had used any other treatment for rosacea within 30 days of the start of therapy. During the course of the study, no other topical or systemic treatment of rosacea was allowed.
  
  
  RESULTS
  Ten of 12 patients showed substantial improvement of erythema, while five of six patients with a papulopustular component noted at least an 80% decrease in the number of lesions.
  
  
  CONCLUSIONS
  It appears pimecrolimus may be efficacious in the treatment of erythrotelangiectatic and papulopustular rosacea and may be considered in patients with recalcitrant disease.
authors.affiliation: Dermatology Clinic, Malcolm Grow Medical Center, Andrews Air Force Base, MD 20762, USA. kevin.crawford@mgmc.af.mil
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Crawford
authors.forename: Brian
authors.initials: B
authors.lastname: Russ
authors.forename: Paul
authors.initials: P
authors.lastname: Bostrom
mesh_terms: D000287:Administration, Topical; D000368:Aged; D003879:Dermatologic Agents / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012393:Rosacea / Q000188:drug therapy*; D016559:Tacrolimus / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; C117268:pimecrolimus; D016559:Tacrolimus