title: XBP1 gene polymorphism (-116C/G) and personality.
abstract: Recently, a polymorphism of the XBP1 gene (-116 C/G) was observed to play a significant role in the development of bipolar mood disorder from the Japanese population. The present study investigated a role of the polymorphism in the development of personality in healthy Japanese volunteers (n = 195). Personality traits were evaluated using NEO Personality Inventory-Revised (NEO PI-R). As a result, a statistical trend for association between the polymorphism (genotype) and the NEO PI-R scores of agreeableness and neuroticism was observed (ANOVA, P = 0.01 and 0.006, respectively). Subjects with the G allele, especially those with G-G genotype, tended to show lower neuroticism and higher agreeableness in the present study. The result is provisional and should be interpreted with caution, partly because the previous study suggested the allele as a risk allele for bipolar disorder. Further studies are required to confirm the results.
authors.affiliation: Department of Psychiatry, University of Tokyo, Bunkyo-ku, Japan.
authors.forename: Chieko
authors.initials: C
authors.lastname: Kato
authors.forename: Chihiro
authors.initials: C
authors.lastname: Kakiuchi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Umekage
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tochigi
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Kato
authors.forename: Tadafumi
authors.initials: T
authors.lastname: Kato
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Sasaki
mesh_terms: D000328:Adult; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics*; D010551:Personality / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors; D000071717:X-Box Binding Protein 1
chemical_list: D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors; D000071717:X-Box Binding Protein 1; C000605543:XBP1 protein, human