title: Permanent alopecia after busulfan chemotherapy.
abstract: Systemic chemotherapy is a well known cause of reversible hair loss. Busulfan chemotherapy, however, is responsible for a permanent alopecia that usually occurs in bone marrow transplant patients. We report two patients with permanent alopecia due to busulfan chemotherapy. Both patients had a diffuse alopecia characterized by greatly reduced hair density with short, thin hair. The pathology showed reduced follicular density in the absence of fibrosis, suggesting that alopecia may result either from hair follicle stem cell destruction or from acute damage to the keratinocytes of the lower portion of some follicles.
authors.affiliation: Department of Dermatology, University of Bologna, Via Massarenti 1, 40138 Bologna, Italy. tosti@med.unibo.it
authors.forename: A
authors.initials: A
authors.lastname: Tosti
authors.forename: B M
authors.initials: BM
authors.lastname: Piraccini
authors.forename: C
authors.initials: C
authors.lastname: Vincenzi
authors.forename: C
authors.initials: C
authors.lastname: Misciali
mesh_terms: D000328:Adult; D000505:Alopecia / Q000139:chemically induced* / Q000473:pathology; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects*; D016026:Bone Marrow Transplantation; D002066:Busulfan / Q000009:adverse effects*; D005260:Female; D006801:Humans; D019172:Transplantation Conditioning / Q000009:adverse effects
chemical_list: D018906:Antineoplastic Agents, Alkylating; D002066:Busulfan