Deoxyribozyme-based ligase logic gates and their initial circuits.
A complete set (YES, NOT, AND, and ANDNOT) of molecular scale logic gates based on ligase deoxyribozymes was constructed. The activity of these gates was visualized through the formation of cascades with downstream phosphodieseterase YES gates, which performed fluorogenic cleavage.
Stojanovic
Milan N
MN
Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, Columbia University, Box 84, 630 West 168th Street, New York, NY 10032, USA. mns18@columbia.edu
Semova
Stanka
S
Kolpashchikov
Dmitry
D
Macdonald
Joanne
J
Morgan
Clint
C
Stefanovic
Darko
D
D001483:Base Sequence; D002384:Catalysis; D011088:DNA Ligases / Q000737:chemistry* / Q000378:metabolism; D021881:DNA, Catalytic / Q000737:chemistry* / Q000378:metabolism; D008128:Logic; D008969:Molecular Sequence Data; D009841:Oligonucleotides / Q000737:chemistry / Q000378:metabolism
D021881:DNA, Catalytic; D009841:Oligonucleotides; D011088:DNA Ligases