Cloning and characterization of TMPRSS6, a novel type 2 transmembrane serine protease.
We have identified TMPRSS6, a novel type 2 transmembrane serine protease. TMPRSS6 possesses all the signature motifs of the family of transmembrane serine proteases (TMPRSSs), including a transmembrane domain, an LDL receptor class A (LDLRA) domain, a scavenger receptor cysteine-rich (SRCR) domain, and a serine protease domain. The substrate specificity of TMPRSS6 is slightly different from those of other TMPRSS family members. Combined with the finding that TMPRSS6 is expressed strongly in the thyroid and weakly in the trachea, this may indicate that TMPRSS6 has a specialized role.
Park
Tae Joo
TJ
Department of Life Science, National Research Laboratory of Proteolysis, Gwangju Institute of Science and Technology, Gwangju 500-712, Korea.
Lee
Yong Jae
YJ
Kim
Hye Jin
HJ
Park
Hye Gyeong
HG
Park
Woo Jin
WJ
D000595:Amino Acid Sequence; D003001:Cloning, Molecular; D005091:Exons / Q000235:genetics; D006801:Humans; D007438:Introns / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism*; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics; D017434:Protein Structure, Tertiary; D011971:Receptors, Immunologic / Q000737:chemistry / Q000235:genetics; D011973:Receptors, LDL / Q000737:chemistry / Q000235:genetics; D051116:Receptors, Scavenger; D051117:Scavenger Receptors, Class A; D017386:Sequence Homology, Amino Acid; D012697:Serine Endopeptidases / Q000235:genetics* / Q000378:metabolism*; D013379:Substrate Specificity; D013961:Thyroid Gland / Q000201:enzymology*; D014132:Trachea / Q000201:enzymology*
D008565:Membrane Proteins; D011971:Receptors, Immunologic; D011973:Receptors, LDL; D051116:Receptors, Scavenger; D051117:Scavenger Receptors, Class A; D012697:Serine Endopeptidases; C504318:TMPRSS6 protein, human