title: The effect of megestrol acetate on oral food and fluid intake in nursing home residents: a pilot study.
abstract: OBJECTIVE
  The objective of this study was to evaluate the effect of megestrol acetate (Megace OS; Bristol-Myers Squibb, Princeton, NJ) on the oral food and fluid intake of nursing home (NH) residents under two conditions: usual NH care and optimal mealtime feeding assistance.
  
  
  METHODS
  We conducted a prospective, preliminary trial in four NHs.
  
  
  METHODS
  Participants (n = 17) were recruited from a larger study designed to assess nutritional care quality. Eligibility for the Megace OS trial required participants to consistently eat less than 75% of most meals under both usual NH care and optimal feeding assistance conditions at baseline.
  
  
  METHODS
  Megace OS, an oral liquid suspension of megestrol acetate, was given daily in a 400-mg dose for 63 days.
  
  
  METHODS
  Each participant's oral food and fluid intake was monitored weekly for 1 day (three meals) during which research staff conducted direct observations of usual NH care (weeks 1, 3, and 5 and day 63) or provided optimal feeding assistance (weeks 2, 4, and 6). Average total percent intake was compared from baseline across the assessment weeks of the trial under the two mealtime care conditions.
  
  
  RESULTS
  Megace OS had a significant effect on oral food and fluid intake only under the optimal mealtime feeding assistance condition, in which average total percent eaten increased from 50% (+/-15%) at baseline to 63% (+/-14%) post-63 days of the trial. There was no change in participants' oral food and fluid intake under the usual NH care condition (average total percent intake at baseline 43% +/- 12% vs. 43% +/- 20% post-63 days).
  
  
  CONCLUSIONS
  The results of this preliminary study suggest that Megace OS is not an effective nutritional intervention to increase oral intake under usual NH care conditions, which is often characterized by inadequate feeding assistance. However, Megace OS in combination with optimal mealtime feeding assistance does significantly increase oral intake in a frail NH sample at high risk for weight loss.
authors.affiliation: University of California, Los Angeles, CA, USA. ssimmons@ucla.edu
authors.forename: Sandra F
authors.initials: SF
authors.lastname: Simmons
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Walker
authors.forename: Dan
authors.initials: D
authors.lastname: Osterweil
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000855:Anorexia / Q000188:drug therapy*; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D002149:Energy Intake / Q000187:drug effects; D004750:Enteral Nutrition / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D019290:Megestrol Acetate / Q000009:adverse effects / Q000627:therapeutic use*; D009735:Nursing Homes; D010865:Pilot Projects; D011446:Prospective Studies; D015430:Weight Gain / Q000187:drug effects
chemical_list: D019290:Megestrol Acetate