A novel one-pot three-component synthesis of 3-halofurans and sequential Suzuki coupling.
A novel sequence of Sonogashira coupling and electrophilic addition to an ynone, with concomitant deprotection and cyclocondensation, opens a new one-pot synthesis of 3-halofurans; the method can be readily elaborated to a new sequential Sonogashira-addition-cyclocondensation-Suzuki reaction to furnish 2,3,5-trisubstituted furans in a one-pot fashion.
Karpov
Alexei S
AS
Organisch-Chemisches Institut der Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 270, D-69120 Heidelberg, Germany.
Merkul
Eugen
E
Oeser
Thomas
T
Müller
Thomas J J
TJ
D018360:Crystallography, X-Ray; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D006219:Halogens / Q000737:chemistry*; D006843:Hydrocarbons, Chlorinated / Q000138:chemical synthesis* / Q000737:chemistry; D007455:Iodine / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure
D005663:Furans; D006219:Halogens; D006843:Hydrocarbons, Chlorinated; D007455:Iodine