A novel strategy for the asymmetric synthesis of chiral cyclopropane carboxaldehydes.
A new way of combining chiral auxiliaries and substrate-directable reactions for asymmetric synthesis is described that employs a three-step sequence of aldol-cyclopropanation-retro-aldol reactions for the stereoselective synthesis of enantiopure cyclopropane carboxaldehydes.
Cheeseman
Matt
M
Department of Chemistry, University of Bath, Bath, UK.
Feuillet
Fred J P
FJ
Johnson
Andrew L
AL
Bull
Steven D
SD
D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D000447:Aldehydes; D003521:Cyclopropanes; C030797:cyclopropane