The influence of some aminoalkanolic xanthone derivatives on central nervous and cardiovascular systems in rodents.
A series of appropriate aminoalkanolic derivatives 2- or 4-methylxanthone was synthesized and evaluated for anticonvulsant activity in the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole seizure threshold (scPtz) assays, and for neurotoxicity (TOX). The most interesting result was the anticonvulsant activity of (R,S)-2N-(6-chloro-2-xanthonemethyl-2N-methylamino-1-propanol hydrochloride (II, which displayed anti-MES and anti-scPtz activity. Some of the obtained compounds (I - IV and V - VII) were also tested for their effect on the circulatory system (the effect on normal electrocardiogram, protection against adrenaline-, barium-, calcium- and/or strophanthine-induced arrhythmias, the effect on the arterial blood pressure and respiratory movements) and acute toxicity.
Librowski
Tadeusz
T
Department of Pharmacodynamics, Faculty of Pharmacy, Medical College, Jagiellonian University, Kraków, Poland.
Czarnecki
Ryszard
R
Jastrzebska-Wiesek
Magdalena
M
Opoka
Wlodzimierz
W
Marona
Henryk
H
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000494:pharmacology; D002317:Cardiovascular Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D004562:Electrocardiography / Q000187:drug effects; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D015656:Respiratory Mechanics / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D044004:Xanthones / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity
D000927:Anticonvulsants; D002317:Cardiovascular Agents; D002491:Central Nervous System Agents; D044004:Xanthones