title: Menotropin (hMG) and idiopathic oligoastenoteratozoospermia (OAT): effects on seminal fluid parameters and on results in ICSI cycles.
abstract: Many studies on gonadotropin treatment in idiopathic OAT have produced inconsistent (75 IU FSH + 75 IU LH) at the dosage of 3 ampoules a week for 90 days in 18 patients with idopathic OAT and testicular volume 12-15 ml. At the end of the cycle seminal fluid parameters and testicular volume were reassessed, comparing them with a homogenous control group including 13 subjects awaiting ICSI, who were not given any kind of pharmacological treatment. Treatment produced a statistically significant improvement in spermatozoa concentration (p = 0.016) and reduction in atypical forms (p = 0.040). We assessed also the impact on oocyte fertilization and pregnancy rates after the use of assisted reproduction techniques in a more restricted group of 8 patients, who had already undergone ICSI cycles before pharmacological therapy. Treatment with menotropin (hMG) appears to improve embryo quality.
authors.affiliation: Andrology Unit, Sexuality Fertility Italian Center Milan, Florence, Italy. staff@cifs.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: Beretta
authors.forename: Egidio
authors.initials: E
authors.lastname: Fino
authors.forename: Luigi
authors.initials: L
authors.lastname: Sibilio
authors.forename: Michelangelo
authors.initials: M
authors.lastname: Dilena
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008596:Menotropins / Q000627:therapeutic use*; D009845:Oligospermia / Q000188:drug therapy*; D011247:Pregnancy / Q000706:statistics & numerical data; D012661:Semen / Q000187:drug effects; D020554:Sperm Injections, Intracytoplasmic
chemical_list: D008596:Menotropins