title: Simulation of the effect of Na+ and Cl- on the velocity of a spreading depression wave using a simplified electrochemical model of synaptic terminals.
abstract: In the study of the spreading depression (SD) wave phenomenon and its dynamics, it is necessary to describe the ionic movements along the extracellular space, as well as between this and the intracellular space. In both cases, the ionic movement includes a double coupling involving the concentration and the potential gradients and hence must be described by electrodiffusion mechanisms. Based on this, the effects of the ionic composition on the characteristics of the wave propagation can be predicted. The influence of varying extracellular sodium and chloride concentrations on the velocity of propagation of the SD wave was investigated by simulation. The results achieved are close to the experimental measurement from the literature. These findings suggest the potentiality of the model proposed in supporting the interpretation of experimental data in neuronal tissues, particularly the SD.
authors.affiliation: COPPE/UFRJ: Programa de Engenharia Biomédica, Centro de Tecnologia, Bloco H, sl 327, Cidade Universitária, Caixa Postal 68510 CEP 21945-970, Rio de Janeiro, RJ, Brazil.
authors.forename: Hewerson Zansávio
authors.initials: HZ
authors.lastname: Teixeira
authors.forename: Antônio-Carlos Guimarães
authors.initials: AC
authors.lastname: de Almeida
authors.forename: Antonio Fernando Catelli
authors.initials: AF
authors.lastname: Infantosi
authors.forename: Michelle Almeida
authors.initials: MA
authors.lastname: Vasconcelos
authors.forename: Mário Antônio
authors.initials: MA
authors.lastname: Duarte
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002645:Chickens; D002713:Chlorine / Q000378:metabolism* / Q000494:pharmacology; D003198:Computer Simulation; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000379:methods; D008959:Models, Neurological; D009431:Neural Conduction / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology*; D009898:Optic Disk / Q000502:physiology*; D017729:Presynaptic Terminals / Q000502:physiology*; D012964:Sodium / Q000378:metabolism* / Q000494:pharmacology; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D002713:Chlorine; D012964:Sodium