title: Morphological alteration in oro-facial CGRP containing motoneurons due to congenital thyroid hypofunction.
abstract: Under congenital thyroid hypofunction, the oro-facial large and small calcitonin gene-related peptide (CGRP) immunoreactive motoneurons were classified into strong, moderate, weak and negative intensity in offspring weaned rats. While 50% of neurons in the trigeminal motor nucleus (Mo5) were of the large type, this value dropped to 30% in hypothyroid pups. Hypothyroid trigeminal accessory nucleus (Mo5-AC) contained 10% large motoneurons versus about 45% in normal pups. Normal facial nucleus (Mo7) had 20% large motoneurons in contrast with 10% in hypothyroid pups. These values are significant in comparison with the normal pattern of oro-facial CGRP positive immunoreactive motoneurons as well as those devoid of immunostaining.
authors.affiliation: Physiology Department and Neuroscience Research Center, Faculty of Medicine, Shahid Beheshti Medical Sciences University, P.O. Box 19835-181, Tehran, Iran. gilabehzadi@yahoo.com
authors.forename: G
authors.initials: G
authors.lastname: Behzadi
authors.forename: F
authors.initials: F
authors.lastname: Ganji
mesh_terms: D000818:Animals; D001835:Body Weight; D015740:Calcitonin Gene-Related Peptide / Q000502:physiology*; D003409:Congenital Hypothyroidism; D005145:Face / Q000294:innervation; D005260:Female; D007037:Hypothyroidism / Q000503:physiopathology*; D007150:Immunohistochemistry; D009046:Motor Neurons / Q000145:classification / Q000502:physiology* / Q000648:ultrastructure; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013961:Thyroid Gland / Q000503:physiopathology* / Q000648:ultrastructure
chemical_list: D015740:Calcitonin Gene-Related Peptide