Refractory coeliac disease: remission with infliximab and immunomodulators.
Coeliac disease is a T-cell-mediated enteropathy induced by gluten. A minority of patients who fail to respond to a gluten-free diet may require intervention with immunomodulating drugs. We report a case of refractory coeliac disease where remission was induced by the anti-tumour necrosis factor-alpha antibody infliximab and was maintained with prednisolone and azathioprine.
Turner
Sue M
SM
Department of Gastroenterology, Bristol Royal Infirmary, Marlborough Street, Bristol, UK. drsueturner@hotmail.com
Moorghen
Moorghen
M
Probert
Chris S J
CS
D000368:Aged; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D002446:Celiac Disease / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D000069285:Infliximab; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D012074:Remission Induction; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
D000911:Antibodies, Monoclonal; D005765:Gastrointestinal Agents; D014409:Tumor Necrosis Factor-alpha; D011239:Prednisolone; D000069285:Infliximab