title: Effects of low-dose perinatal cadmium exposure on tissue zinc and copper concentrations in neonatal mice and on the reproductive development of female offspring.
abstract: It has been suggested that the toxic effects of cadmium (Cd) are the result of interactions with essential metals, such as zinc (Zn) and copper (Cu). Previous studies have shown altered Zn and/or Cu levels in the tissues of rodents that drank water supplemented with >50 ppm Cd. To evaluate the effects of lower level Cd exposure on maternal and neonatal Zn and Cu levels and on the reproductive organs of female offspring, mice were exposed to 0, 1 and 10 ppm Cd in the drinking water from conception to 10 days after birth. The Cd concentrations in the brains of the offspring were higher in the exposed group than in the control group at birth. In the kidneys and livers, the Cd concentrations were higher in the Cd-exposed group 10 days after birth. At birth, increased Zn concentrations were observed in the kidneys and livers of the Cd-exposed offspring, although the Cd concentrations in these tissues did not differ between the exposed and non-exposed groups. The hepatic Cu concentrations of the exposed mice tended to be lower than those of the control mice at birth and were significantly lower 10 days after birth. In addition, Cd exposure tended to delay the timing of vaginal opening and perturbed the estrous cycles of the female offspring. These findings suggest that perinatal Cd exposure, even at low levels, affects the Zn and Cu concentrations of neonates and the reproductive functions of female offspring.
authors.affiliation: Department of Human Ecology, School of International Health, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. ishitobi@humeco.m.u-tokyo.ac.jp
authors.forename: Hiromi
authors.initials: H
authors.lastname: Ishitobi
authors.forename: Chiho
authors.initials: C
authors.lastname: Watanabe
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D002104:Cadmium / Q000493:pharmacokinetics / Q000633:toxicity*; D003300:Copper / Q000378:metabolism*; D030762:Estrous Cycle / Q000187:drug effects; D005260:Female; D005836:Genitalia, Female / Q000187:drug effects / Q000254:growth & development*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012098:Reproduction / Q000187:drug effects*; D014018:Tissue Distribution; D014621:Vagina / Q000187:drug effects / Q000254:growth & development; D015032:Zinc / Q000378:metabolism*
chemical_list: D002104:Cadmium; D003300:Copper; D015032:Zinc