title: Fumonisin B-glucose reaction products are less toxic when fed to swine.
abstract: The effects of fumonisin B-glucose reaction products in swine diets was examined. Pigs were fed diets containing 528 micromol of total fumonisin B/kg (FB), 528 micromol of total FB-glucose adducts/kg (FB-G, 122 micromol of unreacted FB/kg), or 0 micromol of total FB/kg for 15 days to test the efficacy of the FB-G reaction products in detoxifying FB. Weight gain in FB pigs was lower than in FB-G or controls, which was correlated with feed intake reduction in FB pigs. Serum aspartate aminotransferase, gamma-glutamyltransferase, and total bilirubin in FB pigs were higher than in FB-G or control pigs. Serum sphinganine/shingosine ratios in FB pigs were higher than in FB-G or control pigs. Microscopic examination of tissues from FB pigs showed generalized liver necrosis and apoptosis with marked cellular pleomorphism and disorganized hepatic cords. The liver and kidneys in the FB-G group appeared to be normal. Tissues of controls were free of lesions. Results suggest that dietary FB-G products are less toxic to swine and may provide an detoxification approach in instances of widespread FB grain contamination (p < 0.05).
authors.affiliation: Interdepartmental Toxicology Program, Iowa State University, Ames, Iowa 50011, USA.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Fernández-Surumay
authors.forename: Gary D
authors.initials: GD
authors.lastname: Osweiler
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Yaeger
authors.forename: George E
authors.initials: GE
authors.lastname: Rottinghaus
authors.forename: Suzanne
authors.initials: S
authors.lastname: Hendrich
authors.forename: Lucas K
authors.initials: LK
authors.lastname: Buckley
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Murphy
mesh_terms: D000821:Animal Feed; D000818:Animals; D017209:Apoptosis; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D004032:Diet; D037341:Fumonisins / Q000737:chemistry* / Q000633:toxicity*; D005947:Glucose / Q000737:chemistry*; D008099:Liver / Q000473:pathology; D009336:Necrosis; D013552:Swine; D015430:Weight Gain; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D037341:Fumonisins; C056934:fumonisin B2; C056933:fumonisin B1; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D005947:Glucose; D001663:Bilirubin