Computational modeling of dendrites.
Computational methods have been part of neuroscience for many years. For example, models developed with these methods have provided a theory that helps explain the action potential. More recently, as experimental patch-electrode techniques have revealed new biophysics related to dendritic function and synaptic integration, computational models of dendrites have been developed to explain and further illuminate these results, and to predict possible additional behavior. Here, a collection of computational models of dendrites is reviewed. The goal is to help explain how such computational techniques work, some of their limitations, and what one can hope to learn about dendrites by modeling them.
Kath
William L
WL
Departments of Applied Mathematics and Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208-3125, USA.
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D003198:Computer Simulation; D003712:Dendrites / Q000502:physiology*; D004553:Electric Conductivity; D008959:Models, Neurological; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D013569:Synapses / Q000502:physiology