Urinary and serum concentrations of diclofenac after topical application to horses.
The liposomal cream formulation of diclofenac, an NSAID, is an effective, safe, and convenient way to treat localized areas of inflammation in horses. The results of this study reveal urinary and serum concentrations of diclofenac following topical administration of 1% liposomal diclofenac cream for 10 days at the labeled dose and at 2X and 4X the labeled dose. These results demonstrate the slow absorption and elimination of 1% liposomal diclofenac cream and may be useful when estimating the withdrawal time needed before a competition in order to prevent an inadvertent positive drug test.
Anderson
Danielle
D
Department of Physiological Sciences, Racing Laboratory, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA.
Kollias-Baker
Cynthia
C
Colahan
Pat
P
Keene
Robert O
RO
Lynn
Randy C
RC
Hepler
Douglas I
DI
D000279:Administration, Cutaneous; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology* / Q000652:urine; D019540:Area Under Curve; D004008:Diclofenac / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D004334:Drug Administration Schedule; D006736:Horses / Q000378:metabolism*; D008297:Male
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac