Chromosome capture: take me to your kinetochore.
To form a proper mitotic spindle, all kinetochores must capture at least one microtubule plus end. A new computational modeling study shows that a search-and-capture mechanism based on spatially unbiased microtubule dynamic instability is too slow to account for the experimentally observed rate of chromosome capture.
Odde
David J
DJ
Department of Biomedical Engineering, University of Minnesota, Minneapolis 55455, USA.
D002875:Chromosomes / Q000378:metabolism*; D019295:Computational Biology; D003198:Computer Simulation; D018386:Kinetochores / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism*; D008938:Mitosis / Q000502:physiology*; D008962:Models, Theoretical; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D010770:Phosphotransferases / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D008941:Spindle Apparatus / Q000378:metabolism*; D013997:Time Factors
D010770:Phosphotransferases; D010744:Phosphoric Monoester Hydrolases