title: Prognostic importance of various echocardiographic right ventricular functional parameters in patients with symptomatic heart failure.
abstract: Little is known about the prognostic importance of right ventricular (RV) systolic and diastolic function. The purpose of this study was to determine the prognostic power of systolic and diastolic RV functional parameters derived from Doppler tissue imaging of tricuspid annular motion and to assess whether their combination might improve the risk stratification of patients with heart failure. In all, 140 patients with symptomatic heart failure and left ventricular ejection fraction of 40% or less underwent standard echocardiography, Doppler tissue imaging of tricuspid annular motion, and right heart catheterization. They were followed up for a mean period of 17 months for cardiac-related death and nonfatal cardiac events including the implantation of cardioverter-defibrillator and hospitalization for heart failure decompensation. A total of 48 cardiac events occurred; 19 patients died, 26 were hospitalized for heart failure decompensation, and 3 because of the need for implantation of a cardioverter-defibrillator. The peak tricuspid annular velocity during systolic ejection of 10.8 cm/s or less, peak early diastolic tricuspid annular velocity of 8.9 cm/s or less, tricuspid annular acceleration during isovolumic contraction of 2.52 m/s 2 or less, and Doppler RV index (Tei index) of 1.20 or more were found to significantly worsen survival or event-free survival. However, their combination significantly exceeded the predictive potential of individual parameters. The worst survival was predicted by the combination of peak tricuspid annular velocity during systolic ejection of 10.8 cm/s or less plus peak early diastolic tricuspid annular velocity of 8.9 cm/s or less plus tricuspid annular acceleration during isovolumic contraction of 2.52 m/s 2 or less (relative risk 6.17, P < .001), whereas the worst event-free survival was identified by the combination of peak tricuspid annular velocity during systolic ejection of 10.8 cm/s or less plus peak early diastolic tricuspid annular velocity of 8.9 cm/s or less plus Doppler RV index (Tei index) of 1.20 or more (relative risk 3.62, P < .001). In conclusion, the combination of RV systolic and diastolic functional parameters represents a very powerful tool for risk stratification of patients with symptomatic heart failure.
authors.affiliation: Department of Internal Medicine and the Centere of Biostatics and Analyses, Masaryk University, Brno, Czech Republic. jaroslav.meluzin@fnusa.cz
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Meluzin
authors.forename: Lenka
authors.initials: L
authors.lastname: Spinarová
authors.forename: Petr
authors.initials: P
authors.lastname: Hude
authors.forename: Jan
authors.initials: J
authors.lastname: Krejcí
authors.forename: Vladimír
authors.initials: V
authors.lastname: Kincl
authors.forename: Roman
authors.initials: R
authors.lastname: Panovský
authors.forename: Ladislav
authors.initials: L
authors.lastname: Dusek
mesh_terms: D003971:Diastole / Q000502:physiology; D015150:Echocardiography, Doppler; D005260:Female; D006333:Heart Failure / Q000401:mortality / Q000503:physiopathology*; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D018570:Risk Assessment; D013599:Systole / Q000502:physiology; D014261:Tricuspid Valve / Q000000981:diagnostic imaging*; D016278:Ventricular Function, Right