A Michaelis-Menten-style model for the autocatalytic enzyme prostaglandin H synthase.
Prostaglandin H synthase (PGHS) is an autocatalytic enzyme which plays a key role in the arachidonic acid metabolic pathway. PGHS mediates the formation of prostaglandin H2, the precursor for a number of prostaglandins which are important in a wide variety of biological processes, including inflammation, blood clotting, renal function, and tumorigenesis. Here we present a Michaelis-Menten-style model for PGHS. A stability analysis determines when the reaction becomes self-sustaining, and can help explain the regulation of PGHS activity in vivo. We also consider a quasi-steady-state approximation (QSSA) for the model, and present conditions under which the QSSA is expected to be a good approximation. Applying the QSSA for this model can be useful in computationally intensive modeling endeavors involving PGHS.
Tien
Joseph H
JH
Center for Applied Mathematics, Cornell University, 657 Frank H.T. Rhodes Hall, Ithaca, NY 14853, USA. joetien@cam.cornell.edu
Hazelton
William D
WD
Sparks
Rachel
R
Ulrich
Cornelia M
CM
D002384:Catalysis; D003198:Computer Simulation; D007700:Kinetics; D008956:Models, Chemical; D044262:Prostaglandin H2 / Q000737:chemistry / Q000378:metabolism; D011451:Prostaglandin-Endoperoxide Synthases / Q000737:chemistry / Q000378:metabolism*
D044262:Prostaglandin H2; D011451:Prostaglandin-Endoperoxide Synthases