[Combined prophylactic administration of riboxin and algisorbum at 239Pu intake into gastrointestinal tract of rats].
The present study is devoted to the investigation of effectiveness of combined prophylactic administration of riboxin and algisorbum at 239Pu per oral intake and possible mechanisms of their interaction, and also to comparative estimation of effectiveness of combined administration of the preparations at per oral and intra peritoneal methods of riboxin introduction. The experiments have been carried out on white nonlinear rats. Riboxin (per oral and intra peritoneal) and algisorbum (per oral) have been introduced to the rats both separately and combined before per oral 239Pu introduction. Data obtained as a result of the investigation showed that combined riboxin and algisorbum introduction into gastrointestinal tract before 239PU intake lead to greater decrease in the plutonium content in the organs of deposition than single algisorbum administration. Intra peritoneal riboxin introduction reduced effectiveness of per oral algisorbum administration in plutonium binding in GI tract. Efficiency of combined riboxin and algisorbum administration in the reduction of 239Pu accumulation in organs depends on the method of riboxin introduction and develops only at per oral introduction.
Vernigorova
L A
LA
Zhorova
E S
ES
Popov
B A
BA
Parfenova
I M
IM
D000284:Administration, Oral; D000464:Alginates / Q000008:administration & dosage*; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D003627:Data Interpretation, Statistical; D004338:Drug Combinations; D041981:Gastrointestinal Tract; D005965:Glucuronates / Q000008:administration & dosage*; D007274:Injections, Intraperitoneal; D007290:Inosine Diphosphate / Q000008:administration & dosage*; D008099:Liver / Q000378:metabolism; D011005:Plutonium / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011833:Radiation Injuries, Experimental / Q000378:metabolism* / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D011874:Radiometry; D051381:Rats; D013154:Spleen / Q000378:metabolism; D014018:Tissue Distribution
D000464:Alginates; D004338:Drug Combinations; D005965:Glucuronates; D011837:Radiation-Protective Agents; C100766:calcium alginate, glucuronic acid drug combination; D011005:Plutonium; D007290:Inosine Diphosphate