One-pot beta-substitution of enones with alkyl groups to beta-alkyl enones.
Vinylic hydrogens at the beta-position of enones were effectively substituted with alkyl groups in a one-pot procedure to afford beta-alkyl enones in good to high isolated yields by conjugate addition of higher-order dialkyl cyanocuprates to enones, followed by a reaction with N-tert-butylbenzenesulfinimidoyl chloride at -78 degree C.
Matsuo
Jun-Ichi
J
Center for Basic Research, Kitasato Institute, 1-15-1-S105, Kitasato, Sagamihara, Kanagawa 228-8555, Japan. matuo@lisci.kitasato-u.ac.jp.
Aizawa
Yayoi
Y