Identification of candidates for epilepsy surgery in patients with tuberous sclerosis.
The authors reviewed preoperative MRI and EEG findings in relation to postsurgical outcome in 17 patients with refractory epilepsy due to tuberous sclerosis complex (TSC). Resecting concordant MRI (main tuber) and EEG abnormalities offered seizure freedom (8/9, 89%; median follow-up 25 months) comparable to other focal etiologies. Patients with nonconcordant MRI and EEG findings did less well (3/8, 38%, seizure free; p = 0.027, OR = 13).
Lachhwani
D K
DK
Department of Neurology, The Cleveland Clinic Foundation, OH 44195, USA. lachhwd@ccf.org
Pestana
E
E
Gupta
A
A
Kotagal
P
P
Bingaman
W
W
Wyllie
E
E
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D015984:Causality; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography / Q000592:standards; D004827:Epilepsy / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000592:standards; D008297:Male; D019635:Neurosurgical Procedures / Q000592:standards; D018579:Patient Selection; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome; D014402:Tuberous Sclerosis / Q000150:complications* / Q000473:pathology / Q000601:surgery*