title: Survey of human exposure to PCDDs, PCDFs, and coplanar PCBs using hair as an indicator.
abstract: Our environment is polluted with toxic compounds including polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and coplanar polychlorinated biphenyls (Co-PCBs). We investigated the suitability of hair analysis for testing human exposure to toxic compounds. Hair analysis revealed that municipal solid-waste (MSW) incineration workers were exposed to PCDDs, PCDFs, and Co-PCBs at high levels. The total 2,3,7,8-TCDD toxic equivalent concentration in MSW incineration workers was 2.5 times higher than in the general population, thus indicating that the indoor environment of the incineration facility was more polluted than the general environment. There were also characteristic patterns of occurrence of these dioxin-like compounds in the hair of smokers from the general population. We confirmed that hair analysis is useful for evaluating human exposure to PCDDs, PCDFs, and Co-PCBs in the atmosphere.
authors.affiliation: Faculty of Pharmaceutical Science, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan. nakao@pharm.setsunan.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Nakao
authors.forename: O
authors.initials: O
authors.lastname: Aozasa
authors.forename: S
authors.initials: S
authors.lastname: Ohta
authors.forename: H
authors.initials: H
authors.lastname: Miyata
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000032:analysis / Q000378:metabolism; D001572:Benzofurans / Q000032:analysis / Q000378:metabolism*; D000072338:Dibenzofurans, Polychlorinated; D004781:Environmental Exposure / Q000032:analysis*; D004784:Environmental Monitoring / Q000379:methods*; D004785:Environmental Pollutants / Q000032:analysis / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D006197:Hair / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D017745:Incineration; D007564:Japan; D008297:Male; D016273:Occupational Exposure / Q000032:analysis; D011078:Polychlorinated Biphenyls / Q000032:analysis / Q000378:metabolism*; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism*; D012989:Soil Pollutants / Q000032:analysis / Q000378:metabolism
chemical_list: D000395:Air Pollutants, Occupational; D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins; D012989:Soil Pollutants; D011078:Polychlorinated Biphenyls