title: Beta-lactam compounds as apparently uncompetitive inhibitors of HIV-1 protease.
abstract: Compounds of a combinatorial monocyclic beta-lactam library were found to be apparently uncompetitive inhibitors of HIV-1 protease, providing lead compounds for a new class of HIV protease inhibitors.
authors.affiliation: Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Faculty of Medicine, H-4012 Debrecen, Hungary.
authors.forename: Tamás
authors.initials: T
authors.lastname: Sperka
authors.forename: János
authors.initials: J
authors.lastname: Pitlik
authors.forename: Péter
authors.initials: P
authors.lastname: Bagossi
authors.forename: József
authors.initials: J
authors.lastname: Tözsér
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D020650:Combinatorial Chemistry Techniques; D019281:Dimerization; D015195:Drug Design; D016333:HIV Protease / Q000737:chemistry* / Q000378:metabolism; D017320:HIV Protease Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D009052:Leukemia Virus, Murine / Q000187:drug effects / Q000201:enzymology; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure; D019151:Peptide Library; D013329:Structure-Activity Relationship; D047090:beta-Lactams / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D017320:HIV Protease Inhibitors; D019151:Peptide Library; D047090:beta-Lactams; D016333:HIV Protease