(S,S)-(+)-pseudoephedrine as chiral auxiliary in asymmetric acetate aldol reactions.
The asymmetric acetate-type aldol reaction using (S,S)-(+)-pseudoephedrine has been studied in detail. Experimental variables like the nature of the metal counterion of the enolate, the presence of additives and the structure of the aldehyde have been examined in order to reach to the highest possible yields and diastereoselectivities.
Rodríguez
Mónica
M
Departamento de Química Orgánica II, Facultad de Ciencia y Tecnología, Universidad del Pais Vasco/Euskal Herriko Unibertsitatea, P.O. Box 644, 48080, Bilbao, Spain.
Vicario
Jose L
JL
Badía
Dolores
D
Carrillo
Luisa
L