Subacute sclerosing panencephalitis (SSPE) associated with congenital measles infection.
A 13-month-old male presented with repetitive episodes of myoclonic jerks of the head and extremities for two months. His past medical history revealed that his non-immunized mother had measles at the time of delivery. Measles antibody titers in serum and cerebrospinal fluid (CSF) were 1/512 (hemagglutinin inhibition [HI]) and 1/128 HI, respectively. Immunofixation electrophoresis of CSF revealed an oligoclonal IgG band. The magnetic resonance imaging (MRI) of the brain on T2-weighted images showed lesions of high signal intensity in the subcortical white matter. Electroencephalography (EEG) revealed periodic high-amplitude slow waves. Diagnosis of subacute sclerosing panencephalitis (SSPE) was based upon clinical presentation, a characteristic EEG, and abnormal CSF studies. MRI findings supported the diagnosis. To the best of our knowledge, this is only the 3rd case to date, of SSPE-associated congenital measles in the literature.
Simşek
Enver
E
Department of Pediatrics, Abant Izzet Baysal University, Düzce Faculty of Medicine, Düzce, Turkey.
Oztürk
Ayhan
A
Yavuz
Cevdet
C
Kocabay
Kenan
K
D000914:Antibodies, Viral / Q000097:blood; D001921:Brain / Q000473:pathology; D004569:Electroencephalography; D005334:Fever / Q000209:etiology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D008457:Measles / Q000150:complications* / Q000151:congenital / Q000821:virology; D018103:Morbillivirus / Q000276:immunology; D009207:Myoclonus / Q000209:etiology; D013344:Subacute Sclerosing Panencephalitis / Q000150:complications*
D000914:Antibodies, Viral; D007074:Immunoglobulin G