title: Evening primrose oil effects on osteoclasts during tooth movement.
abstract: This study was conducted to investigate the influence of supplemented evening primrose oil (EPO) on osteoclast expression during experimental tooth movement in rats. Forty-eight 10-week-old male Sprague-Dawley rats were divided into experimental and control groups. Animals in the experiment group were fed a 7.25 g/kg daily dose of EPO orally by gastric intubation for 20 days before orthodontic tooth movement. The animals in the control group received an equivalent volume of distilled water by the same method. On day 21, a 40-g mesial tipping force was applied to the maxillary right first molar of each rat. After loading, six animals in each group were sacrificed on days 0, 3, 7, and 14 with the appliance in situ. On day 3, the number of osteoclasts on the appliance side of the experimental group was significantly increased compared with the control group (P < .05). On day 7, the number of osteoclasts on the non-appliance side of the experimental group was significantly increased compared with the control group (P < .05). This study indicates that oral administration of EPO can increase the number of osteoclasts and may accelerate orthodontic tooth movement.
authors.affiliation: Department of Oral Diagnosis, Faculty of Dentistry, Khon Kaen University, Khon Kaen 40002, Thailand. suvi_taw@kku.ac.th
authors.forename: Suwimol
authors.initials: S
authors.lastname: Taweechaisupapong
authors.forename: Nitipavee
authors.initials: N
authors.lastname: Srisuk
authors.forename: Chawalit
authors.initials: C
authors.lastname: Nimitpornsuko
authors.forename: Thepharith
authors.initials: T
authors.lastname: Vattraphoudes
authors.forename: Charunee
authors.initials: C
authors.lastname: Rattanayatikul
authors.forename: Keith
authors.initials: K
authors.lastname: Godfrey
mesh_terms: D000818:Animals; D016022:Case-Control Studies; D005228:Fatty Acids, Essential / Q000494:pharmacology*; D008041:Linoleic Acids; D008297:Male; D008963:Molar; D031665:Oenothera biennis; D009967:Orthodontic Appliances; D010010:Osteoclasts / Q000187:drug effects*; D010938:Plant Oils; D051381:Rats; D017207:Rats, Sprague-Dawley; D014087:Tooth Movement Techniques; D017965:gamma-Linolenic Acid
chemical_list: D005228:Fatty Acids, Essential; D008041:Linoleic Acids; D010938:Plant Oils; C028498:evening primrose oil; D017965:gamma-Linolenic Acid