title: Theories of adaptation: what they do and don't say.
abstract: Theoretical work on adaptation has lagged behind experimental. But two classes of adaptation model have been partly explored. One is phenotypic and the other DNA sequence based. I briefly consider an example of each--Fisher's geometric model and Gillespie's mutational landscape model, respectively--reviewing recent results. Despite their fundamental differences, these models give rise to several strikingly similar results. I consider possible reasons for this congruence. I also emphasize what predictions do and, as important, do not follow from these models.
authors.affiliation: Department of Biology, University of Rochester, Rochester, NY 14627, USA. aorr@mail.rochester.edu
authors.forename: H Allen
authors.initials: HA
authors.lastname: Orr
mesh_terms: D000220:Adaptation, Biological / Q000235:genetics*; D005075:Biological Evolution; D008957:Models, Genetic; D040641:Quantitative Trait Loci; D012641:Selection, Genetic