title: Pharmacokinetics of ciprofloxacin in eels by high-performance liquid chromatography with fluorescence detection.
abstract: The plasma kinetics of ciprofloxacin (CF) were investigated in the eels after administration by oral gavage and bath treatment. Plasma concentrations of CF were determined by high-performance liquid chromatography with fluorescence detection. The mean concentration time data after oral gavage of a single dose (10.0 mg/kg CF) and after bath treatment by exposure (10 microg/ml CF) to medicated water for 48 h were both best fitted by a one-compartment model. After oral gavage in eels, the half-time of absorption (T1/2Ka) was 0.10 h, the half-time of elimination (T1/2Ke) was 51.87 h, and the maximum plasma concentration (Cmax) was 0.4552 microg/ml at Tmax 0.88 h. After bath treatment, the (T1/2Ka) was 0.02 h, the (T1/2Ke) was 15.46 h, and the Cmax was 0.1175 microg/mL at Tmax 0.22 h.
authors.affiliation: Institute of Food Safety and Environmental Monitoring, Fuzhou University, Fuzhou 350002, People's Republic of China. zhxie@fzu.edu.cn
authors.forename: Liangqia
authors.initials: L
authors.lastname: Guo
authors.forename: Zenghong
authors.initials: Z
authors.lastname: Xie
authors.forename: Xucong
authors.initials: X
authors.lastname: Lin
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Wu
authors.forename: Bin
authors.initials: B
authors.lastname: Qiu
authors.forename: Yubin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hainan
authors.initials: H
authors.lastname: You
authors.forename: Guonan
authors.initials: G
authors.lastname: Chen
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000097:blood* / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D002939:Ciprofloxacin / Q000097:blood* / Q000493:pharmacokinetics; D004524:Eels / Q000097:blood*; D005453:Fluorescence
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin