title: [New oxaanalogues of spermine].
abstract: A new isosteric charge-deficient spermine analogue, 1,12-diamino-4,9-diaza-5-oxadodecan, and O-(7-amino-4-azaheptyl)oxime of 3-aminopropanal, a stable analogue of the Schiff base intermediate in the enzymatic oxidation of spermine, were synthesized. The possible use of these compounds for the inhibition of spermine oxidase is discussed.
authors.forename: A R
authors.initials: AR
authors.lastname: Khomutov
authors.forename: A R
authors.initials: AR
authors.lastname: Simonian
authors.forename: J
authors.initials: J
authors.lastname: Vespalainen
authors.forename: T A
authors.initials: TA
authors.lastname: Keinanen
authors.forename: L
authors.initials: L
authors.lastname: Alhonen
authors.forename: J
authors.initials: J
authors.lastname: Janne
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000037:antagonists & inhibitors; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000737:chemistry; D013096:Spermine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D000097667:Polyamine Oxidase
chemical_list: D000587:Oxidoreductases Acting on CH-NH Group Donors; D012545:Schiff Bases; D013096:Spermine; D000097667:Polyamine Oxidase; C502958:1,12-diamino-4,9-diaza-5-oxadodecan; C502959:O-(7-amino-4-azaheptyl)oxime of 3-aminopropanal