[Study of effectiveness of long-term per oral and parenteral cincacine administration at parenteral 241Am incorporation into the organism].
Effect of long-term (during 4 weeks) cincacine administration following single parenteral 241Am intake has been studied on rats depending on method (per oral or parenteral), dosage and time of treatment initiation. Cincacine administration leads to limitation of radionuclide incorporation in the major organs of deposition for the both methods of introduction. At the parenteral 241Am intake in the organism parenteral cincacine administration was found to be more effective compared to per oral cincacine administration even in case of its dose increase by a factor of 6 and 12. At the parenteral introduction of the preparation, time of treatment beginning is more significant than at per oral administration.
Zhorova
E S
ES
Il'in
L A
LA
Popov
B A
BA
Parfenova
I M
IM
D000284:Administration, Oral; D000576:Americium / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002614:Chelating Agents / Q000008:administration & dosage*; D041981:Gastrointestinal Tract / Q000378:metabolism; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D004369:Pentetic Acid / Q000008:administration & dosage*; D011833:Radiation Injuries, Experimental / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
D002614:Chelating Agents; D004369:Pentetic Acid; D000576:Americium