Skin and platelet alpha-synuclein as peripheral biomarkers of Parkinson's disease.
Parkinson's disease (PD) is a heterogeneous disease that can be difficult to diagnose, and for which we have no simple effective biomarker. In this study we have investigated whether peripheral alpha-synuclein might represent a useful biomarker given that it has a central role in the pathogenesis of PD. We found that full length and truncated alpha-synuclein is present in platelets, but the amount is very variable and does not correlate with disease presence or severity. Furthermore, we show that alpha-synuclein can be detected by immunoblotting in some, but not all, human skin biopsies, but again its level does not correlate with disease presence or severity. We conclude that skin or platelet alpha-synuclein would not be an appropriate diagnostic biomarker for PD.
Michell
Andrew W
AW
Cambridge Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge CB22PY, UK. awm13@cam.ac.uk
Luheshi
Leila M
LM
Barker
Roger A
RA
D015415:Biomarkers / Q000032:analysis*; D001706:Biopsy; D001792:Blood Platelets / Q000737:chemistry* / Q000378:metabolism; D015153:Blotting, Western; D006801:Humans; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010300:Parkinson Disease / Q000175:diagnosis*; D010865:Pilot Projects; D012867:Skin / Q000737:chemistry* / Q000378:metabolism; D051843:Synucleins; D051844:alpha-Synuclein
D015415:Biomarkers; D009419:Nerve Tissue Proteins; C497604:SNCA protein, human; D051843:Synucleins; D051844:alpha-Synuclein