The synthesis of water soluble decalin-based thiols and S-nitrosothiols--model systems for studying the reactions of nitric oxide with protein thiols.
The syntheses of three decalin-based tert-thiols displaying varying degrees of solubility in aqueous milieu are described. The S-nitroso derivatives of these compounds have also been prepared and the structures of two of these determined by single crystal X-ray diffraction. These compounds have been designed for studying the interaction of nitric oxide (NO) with thiols under physiological conditions.
Spivey
Alan C
AC
Department of Chemistry, Imperial College, South Kensington campus, London, UK SW7 2AZ.
Colley
Jacqueline
J
Sprigens
Lindsey
L
Hancock
Susan M
SM
Cameron
D Stuart
DS
Chigboh
Kordi I
KI
Veitch
Gemma
G
Frampton
Christopher S
CS
Adams
Harry
H
D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009281:Naphthalenes / Q000737:chemistry*; D009569:Nitric Oxide / Q000737:chemistry*; D012995:Solubility; D021241:Spectrometry, Mass, Electrospray Ionization; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D014867:Water / Q000737:chemistry
D009281:Naphthalenes; D013438:Sulfhydryl Compounds; D014867:Water; D009569:Nitric Oxide; C007229:decalin