title: Reduced word-repetition effect in the event-related potentials of thought-disordered patients with schizophrenia.
abstract: Repetition effect in event-related potentials (ERPs) was studied in 10 non-thought-disordered (non-TD) patients with schizophrenia, 8 thought-disordered (TD) patients with schizophrenia, and 10 normal control subjects while they performed a semantic categorization task with incidental word repetitions. All patients were in a stable or partially remitted stage. Although both healthy control and non-TD groups produced more positive ERPs to the repeated words than to the new words (ERP repetition effect) for 250-500 ms, the TD group did not show the ERP repetition effect. These findings suggest that the abnormal attenuation of the ERP repetition effect during semantic processing may be more prominent in schizophrenic patients with thought disorder than in those without the symptom.
authors.affiliation: Department of Psychiatry, Tohoku University School of Medicine, Sendai 980-8574, Japan. kaz-mat@umin.ac.jp
authors.forename: Kazunori
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Hisato
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Masaki
authors.initials: M
authors.lastname: Nakamura
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Sakai
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Miura
authors.forename: Tomonori
authors.initials: T
authors.lastname: Kato
authors.forename: Shinya
authors.initials: S
authors.lastname: Miwa
authors.forename: Takashi
authors.initials: T
authors.lastname: Ueno
authors.forename: Hidemitsu
authors.initials: H
authors.lastname: Saito
authors.forename: Hiroo
authors.initials: H
authors.lastname: Matsuoka
mesh_terms: D000328:Adult; D000368:Aged; D001288:Attention / Q000502:physiology*; D002540:Cerebral Cortex / Q000503:physiopathology; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006185:Habituation, Psychophysiologic / Q000502:physiology*; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D008875:Middle Aged; D011930:Reaction Time / Q000502:physiology; D012016:Reference Values; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012660:Semantics; D013223:Statistics as Topic; D013850:Thinking / Q000502:physiology*; D014706:Verbal Learning / Q000502:physiology*