title: Chemopreventive and therapeutic effects of curcumin.
abstract: Chemoprevention is a promising anti-cancer approach with reduced secondary effects in comparison to classical chemotherapy. Curcumin, one of the most studied chemopreventive agents, is a natural compound extracted from Curcuma longa L. that allows suppression, retardation or inversion of carcinogenesis. Curcumin is also described as an anti-tumoral, anti-oxidant and anti-inflammatory agent capable of inducing apoptosis in numerous cellular systems. In this review, we describe both properties and mode of action of curcumin on carcinogenesis, gene expression mechanisms and drug metabolism.
authors.affiliation: Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hôpital Kirchberg, 9, rue Edward Steichen, L-2540 Luxembourg, Luxembourg.
authors.forename: Annelyse
authors.initials: A
authors.lastname: Duvoix
authors.forename: Romain
authors.initials: R
authors.lastname: Blasius
authors.forename: Sylvie
authors.initials: S
authors.lastname: Delhalle
authors.forename: Michaël
authors.initials: M
authors.lastname: Schnekenburger
authors.forename: Franck
authors.initials: F
authors.lastname: Morceau
authors.forename: Estelle
authors.initials: E
authors.lastname: Henry
authors.forename: Mario
authors.initials: M
authors.lastname: Dicato
authors.forename: Marc
authors.initials: M
authors.lastname: Diederich
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D018890:Chemoprevention; D003474:Curcumin / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004789:Enzyme Activation; D006801:Humans; D016328:NF-kappa B / Q000037:antagonists & inhibitors; D009369:Neoplasms / Q000517:prevention & control*; D014157:Transcription Factors / Q000037:antagonists & inhibitors
chemical_list: D000970:Antineoplastic Agents; D016328:NF-kappa B; D014157:Transcription Factors; D003577:Cytochrome P-450 Enzyme System; D003474:Curcumin