title: Polyhydroxylated steroids from the soft coral Sinularia dissecta.
abstract: A repeated silica gel column chromatography followed by HPLC purification on the methanol extract of marine soft coral Sinularia dissecta, resulted in the isolation of fifteen polyhydroxylated steroids (1-15), involving six new C-18 functionalized steroids, 3beta-acetoxy-1alpha,11alpha-dihydroxygorgost-5-en-18-oic acid (1), gorgost-5-en-1alpha,3beta,11alpha,18-tetrol (2), 18-acetoxy-1alpha,3beta,11alpha-trihydroxygorgost-5-ene (3), 24(S)-3beta-acetoxy-1alpha, 11alpha-dihydroxyergost-5-en-18-oic acid (4), 24(S)-ergost-5-en-1alpha,3beta,11alpha,18-tetrol (5), and dissectolide (6). The structures of the new compounds were determined on the basis of extensive spectroscopic data (IR, MS, (1)H and (13)C NMR, HMQC, HMBC, and NOESY) analysis. Compound 6 was found as an unusual sterol bearing a lactone functionality.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Jin
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Deng
authors.forename: Yuehu
authors.initials: Y
authors.lastname: Pei
authors.forename: Hongzheng
authors.initials: H
authors.lastname: Fu
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Leen
authors.initials: L
authors.lastname: Van Ofwegen
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
authors.forename: Wenhan
authors.initials: W
authors.lastname: Lin
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D006900:Hydroxylation; D013058:Mass Spectrometry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification*
chemical_list: D013256:Steroids