Long-term outcome of nutritional therapy in paediatric Crohn's disease.
OBJECTIVE
Long-term effects of using enteral feed therapy to induce remission in paediatric Crohn's disease are poorly documented. The aim of this study is to examine the short and long-term impact of enteral nutrition as primary therapy for children with newly diagnosed Crohn's disease.


METHODS
Since 1994, a data base was set up in Bristol for all children with inflammatory bowel diseases. The data of newly diagnosed patients with Crohn's disease in whom enteral nutrition was used as the primary therapy (44 children) was analysed, with particular reference to time to remission, to first and subsequent relapse, and to first steroid usage.


RESULTS
Forty out of 44 patients (90%) responded to enteral nutrition, with a median time to remission of 6 weeks. 25 of these 40 (62%) relapsed, with a median duration of remission of 54.5 weeks (range 4-312). 15 (38%) have not relapsed. 21 of the 44 (47%) have not received steroids. In those who eventually required steroids, their use was postponed for a median 68 weeks (range 6-190). Site of disease activity had no impact on response to enteral nutrition, but there was a trend towards earlier relapse in those with isolated colonic involvement.


CONCLUSIONS
This data suggests that there are long-term benefits to the use of enteral nutrition to induce remission in children with Crohn's disease Steroids may be avoided in nearly half the cases and, in others, their use postponed by 68 weeks.
Knight
C
C
Gastroenterology and Nutrition Unit, Bristol Royal Hospital for Children, Upper Mauldlin Street, Bristol BS2 8BJ, UK.
El-Matary
Wael
W
Spray
Christine
C
Sandhu
Bhupinder K
BK
D000293:Adolescent; D002648:Child; D003424:Crohn Disease / Q000188:drug therapy / Q000628:therapy*; D004750:Enteral Nutrition / Q000379:methods*; D005260:Female; D006128:Growth; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D012008:Recurrence; D012074:Remission Induction; D013256:Steroids / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome
D013256:Steroids