title: Single-cell transcriptional profiles and spatial patterning of the mammalian olfactory epithelium.
abstract: In order to gain insights into the regulatory control of neuronal diversity in the mammalian olfactory system, we have identified the transcriptional profile of individual olfactory neurons. A single cell microarray strategy was performed to search for candidate genes involved in the molecular specification of dorso-ventral zones of olfactory receptor (OR) expression. Several transcripts were identified that display differential expression in distinct OR zones, including a novel family of genes, the Lozenge-like (Lzl) genes which share sequence consensus motifs with Lozenge, a transcription factor involved in the patterning of the Drosophila olfactory and visual systems.
authors.affiliation: Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA, USA.
authors.forename: Ian
authors.initials: I
authors.lastname: Tietjen
authors.forename: Jason
authors.initials: J
authors.lastname: Rihel
authors.forename: Catherine G
authors.initials: CG
authors.lastname: Dulac
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D019521:Body Patterning / Q000235:genetics / Q000502:physiology*; D017124:Conserved Sequence; D017931:DNA Primers; D004847:Epithelial Cells / Q000166:cytology / Q000502:physiology; D020869:Gene Expression Profiling; D051379:Mice; D008969:Molecular Sequence Data; D009420:Nervous System / Q000196:embryology; D018034:Olfactory Receptor Neurons / Q000166:cytology / Q000502:physiology*; D016133:Polymerase Chain Reaction; D014157:Transcription Factors / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D017931:DNA Primers; D014157:Transcription Factors