[Meta-analysis of postoperative adjuvant chemotherapy for Dukes' B colorectal carcinoma].
OBJECTIVE
The necessity of adjuvant chemotherapy after radical surgery for patients with Dukes' B (stage II) colorectal carcinoma remains controversial. This study was to evaluate effect of postoperative adjuvant chemotherapy on survival of Dukes' B patients with meta-analysis.


METHODS
The results of literatures on postoperative adjuvant chemotherapy for Dukes' B patients from 1985 to 2003 were analyzed synthetically.The 5-year survival rates of postoperative adjuvant chemotherapy group and surgery alone group were compared.


RESULTS
Eight published randomized controlled trails were eligible, and had 6 518 patients totally. The 5-year mortality was lower in postoperative adjuvant chemotherapy group than in surgery alone group with odds ratio (OR) of 0.79, and 95% confidence interval (CI) of 0.7-0.9, (P<0.05).


CONCLUSIONS
Postoperative adjuvant chemotherapy could improve 5-year survival rate of Dukes' B patients.
Wan
Xiang-Bin
XB
Department of Abdominal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P.R.China. zzpan@21cn.com.
Pan
Zhi-Zhong
ZZ
Chen
Gong
G
Li
Li-Ren
LR
Wan
De-Sen
DS
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D006801:Humans; D009367:Neoplasm Staging; D016017:Odds Ratio; D011184:Postoperative Period; D016032:Randomized Controlled Trials as Topic; D015996:Survival Rate
D000970:Antineoplastic Agents