Synthesis, spectroscopic and biological properties of bis(3-arylimidazolidinyl-1)methanes. A novel family of antimicrobial agents.
Synthesis, spectroscopic and biological properties of new bis(3-arylimidazolidinyl-1)methanes are described. These compounds were synthesized by condensation reaction between N-arylethylenediamines and formaldehyde. Chemical structures were confirmed by means of their (1)H- and (13)C-NMR and mass spectroscopic data. Investigation of in vitro antimicrobial activity was performed using Gram-negative and Gram-positive bacteria as well as antifungal studies against Aspergillus niger and Candida albicans. Minimal inhibitory concentrations of active compounds were determined.
Perillo
Isabel
I
Department of Organic Chemistry, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Junín 956 (1113) Buenos Aires, Argentina. iperillo@ffyb.uba.ar
Repetto
Evangelina
E
Caterina
María Cristina
MC
Massa
Rosana
R
Gutkind
Gabriel
G
Salerno
Alejandra
A
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005029:Ethylenediamines / Q000737:chemistry; D005557:Formaldehyde / Q000737:chemistry; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D005029:Ethylenediamines; D007093:Imidazoles; D005557:Formaldehyde; D008697:Methane