[Myocardial protective effects of pretreatment with captopril on ischemia-reperfusion myocardium in rabbits].
OBJECTIVE
To investigate the effect of pretreatment with captopril on myocardium ischemia-reperfusion injury in atherosclerotic rabbits.


METHODS
Thirty-two New Zealand white rabbits were assigned randomly to the normally feed group, cholesterol-feed (CF) group, and cholesterol food plus captopril group (cap-feed group), which were fed for 10 weeks. We examined the changes in the size of the infarct and changes in the myocardium ultrastructure resulting from coronary ischemia/reperfusion. Levels of endothelin (ET) and nitic oxide (NO) were measured in the different experiment stages.


RESULTS
The ET levels significantly increased and the content of NO significantly decreased in the CF group compared with those of the cap-feed group. The ultrastructure of myocardium cell was slightly destroyed and the infarct size was significantly smaller in the cap-feed group than the normally feed rabbits and CF rabbits.


CONCLUSIONS
The long-term captopril treatment can lighten the severity of myocardial injury produced by coronary ischemia/reperfusion.
Hu
Ming-song
MS
Department of Cardiothoracic Surgery, Second Xiangya Hospital ,Central South University , Changsha 410011, China. humingsong1973@hotmail.com
Hu
Jian-guo
JG
Zhou
Xin-min
XM
Feng
Yao-guang
YG
Wang
Hui
H
Yang
Jin-fu
JF
D000818:Animals; D002216:Captopril / Q000494:pharmacology / Q000627:therapeutic use*; D016232:Endothelins / Q000097:blood; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy*; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D009206:Myocardium / Q000648:ultrastructure; D009569:Nitric Oxide / Q000097:blood; D011817:Rabbits; D011897:Random Allocation
D016232:Endothelins; D009569:Nitric Oxide; D002216:Captopril