title: Components of successful lead generation.
abstract: This review aims to give an overview of current good practice in the prosecution of Lead Generation. It will assess experiences across the field as judged from the contents of the limited number of peer-review disclosures to date. It will also rely heavily on the experiences of the authors from many campaigns within this organisation. Its focus will be on the assembly of an appropriate compound collection for application in High Throughput Screening (HTS), the prosecution of HTS, the profiling of HTS output and, lastly the Hit-to-Lead optimisation of selected HTS output. Excluded from the scope are detailed aspects of library design [1], parallel synthesis [2], virtual library applications [3], virtual screening [4] and fragment screening [5] approaches, all of which have been the subject of recent reviews.
authors.affiliation: Department of Medicinal Chemistry, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, LE11 5RH UK.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Davis
authors.forename: David J
authors.initials: DJ
authors.lastname: Keeling
authors.forename: John
authors.initials: J
authors.lastname: Steele
authors.forename: Nicholas P
authors.initials: NP
authors.lastname: Tomkinson
authors.forename: Alan C
authors.initials: AC
authors.lastname: Tinker
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans