title: Concomitant chemoradiotherapy for muscle-invasive bladder cancer: the way forward for bladder preservation?
abstract: Muscle-invasive bladder cancer is a common malignancy with a high mortality rate. Despite ongoing debates about the optimal primary intervention, radical cystectomy remains the cornerstone of first-line therapy in many institutions. Over the past decade, bladder-preserving strategies involving transurethral resection (TUR), chemotherapy and radiotherapy have evolved. However, the advantage of these approaches over radiation treatment as monotherapy has yet to be fully evaluated. In other tumour models, most notably cervical and anal cancer, radiation and chemotherapy delivered concomitantly have resulted in significant survival advantages. Here, we consider the potential value of this approach in the treatment of invasive bladder cancer. Concomitant chemoradiotherapy is currently the mainstay of several bladder-preserving programmes reported in the medical literature. Overall, local control and survival rates compare favourably with contemporary cystectomy series; however, difficulties in drawing valid conclusions are highlighted. Concomitant chemoradiotherapy may have a role in the management of certain patient subgroups, and the debate should remain open. Further large-scale randomised trials are needed, and information regarding bladder function and quality of life after treatment is lacking at present. The importance of close follow-up and prompt salvage cystectomy is emphasised.
authors.affiliation: Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK.
authors.forename: B T
authors.initials: BT
authors.lastname: Sherwood
authors.forename: G D D
authors.initials: GD
authors.lastname: Jones
authors.forename: J K
authors.initials: JK
authors.lastname: Mellon
authors.forename: R C
authors.initials: RC
authors.lastname: Kockelbergh
authors.forename: W P
authors.initials: WP
authors.lastname: Steward
authors.forename: R P
authors.initials: RP
authors.lastname: Symonds
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D006801:Humans; D011878:Radiotherapy / Q000379:methods*; D016896:Treatment Outcome; D001743:Urinary Bladder / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000628:therapy*; D013520:Urologic Surgical Procedures / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents