title: Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to MRI.
abstract: We employ diffuse optical tomography (DOT) to track treatment progress in a female subject presenting with locally advanced invasive carcinoma of the breast during neoadjuvant chemotherapy. Three-dimensional images of total hemoglobin concentration and scattering identified the tumor. Our measurements reveal tumor shrinkage during the course of chemotherapy, in reasonable agreement with magnetic resonance images of the same subject. A decrease in total hemoglobin concentration contrast between tumor and normal tissue was also observed over time. The results demonstrate the potential of DOT for measuring physiological parameters of breast lesions during chemotherapy.
authors.affiliation: Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, Pennsylvania 19104-6396, USA. rgchoe@alumni.upenn.edu
authors.forename: Regine
authors.initials: R
authors.lastname: Choe
authors.forename: Alper
authors.initials: A
authors.lastname: Corlu
authors.forename: Kijoon
authors.initials: K
authors.lastname: Lee
authors.forename: Turgut
authors.initials: T
authors.lastname: Durduran
authors.forename: Soren D
authors.initials: SD
authors.lastname: Konecky
authors.forename: Monika
authors.initials: M
authors.lastname: Grosicka-Koptyra
authors.forename: Simon R
authors.initials: SR
authors.lastname: Arridge
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Czerniecki
authors.forename: Douglas L
authors.initials: DL
authors.lastname: Fraker
authors.forename: Angela
authors.initials: A
authors.lastname: DeMichele
authors.forename: Britton
authors.initials: B
authors.lastname: Chance
authors.forename: Mark A
authors.initials: MA
authors.lastname: Rosen
authors.forename: Arjun G
authors.initials: AG
authors.lastname: Yodh
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy* / Q000473:pathology*; D017024:Chemotherapy, Adjuvant / Q000379:methods*; D005260:Female; D006454:Hemoglobins / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D007834:Lasers; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008327:Mammography / Q000379:methods; D008408:Mastectomy; D015233:Models, Statistical; D010100:Oxygen / Q000378:metabolism; D013055:Spectrophotometry, Infrared; D041622:Tomography, Optical / Q000379:methods*
chemical_list: D006454:Hemoglobins; D010100:Oxygen