title: Aerosols in the study of convective acinar mixing.
abstract: Convective mixing (CM) refers to the different transport mechanisms except Brownian diffusion that irreversibly transfer inspired air into resident air and can be studied using aerosol bolus inhalations. This paper provides a review of the present understanding of how each of these mechanisms contributes to CM. Original data of the combined effect of stretch and fold and gravitational sedimentation on CM are also presented. Boli of 0.5 microm-diameter particles were inhaled at penetration volumes (V(p)) of 300 and 1200 ml in eight subjects. Inspiration was followed by a 10-s breath hold, during which small flow reversals (FR) were imposed, and expiration. There was no physiologically significant dependence in dispersion and deposition with increasing FR. The results were qualitatively similar to those obtained in a previous study in microgravity in which it was speculated that the phenomenon of stretch and fold occurred during the first breathing cycle without the need of any subsequent FR.
authors.affiliation: Physiology/NASA Laboratory 0931, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0931, USA. cdarquenne@ucsd.edu
authors.forename: Chantal
authors.initials: C
authors.lastname: Darquenne
authors.forename: G Kim
authors.initials: GK
authors.lastname: Prisk
mesh_terms: D000328:Adult; D000336:Aerosols / Q000493:pharmacokinetics*; D000704:Analysis of Variance; D018481:Convection; D005260:Female; D006801:Humans; D008176:Lung Volume Measurements / Q000379:methods; D008297:Male; D008875:Middle Aged; D011650:Pulmonary Alveoli / Q000502:physiology*; D011653:Pulmonary Diffusing Capacity; D011659:Pulmonary Gas Exchange / Q000502:physiology*; D015656:Respiratory Mechanics / Q000502:physiology*
chemical_list: D000336:Aerosols