title: TP53 codon 72 polymorphism and risk for cervical cancer in Portugal.
abstract: High-risk human papillomavirus are essential for the development of cervical cancer; however, TP53 is the most frequently altered tumor suppressor gene among tumors and is described as a cofactor for cervical carcinogenesis. TP53 has two common polymorphic forms encoding either proline or arginine, at position 72, and the presence of homozygous arginine has been reported as a risk factor for cervical cancer in many populations. We evaluated the effect of this TP53 polymorphism in a northern Portuguese population. We analyzed blood samples of 385 women; 20 with low-grade squamous intraepithelial lesion (SIL), 56 with high-grade SIL, 164 with invasive cervical cancer, and 145 healthy controls, using allele specific-polymerase chain reaction methodology. We observed an increased frequency of the Arg/Arg genotype in the cancer group, but no statistical significance was found between cases and controls (P>0.05). Our results indicate that there is no association between the presence of the Arg allele in codon 72 of TP53 polymorphism and risk of cervical cancer in our population.
authors.affiliation: Molecular Oncology Unit, Portuguese Institute of Oncology-Porto, Laboratórios 4 Piso, Rua Dr. António Bernardino Almeida, 4200-072 Porto, Portugal.
authors.forename: Alexandra M
authors.initials: AM
authors.lastname: Santos
authors.forename: Hugo
authors.initials: H
authors.lastname: Sousa
authors.forename: Raquel
authors.initials: R
authors.lastname: Catarino
authors.forename: Daniela
authors.initials: D
authors.lastname: Pinto
authors.forename: Deolinda
authors.initials: D
authors.lastname: Pereira
authors.forename: André
authors.initials: A
authors.lastname: Vasconcelos
authors.forename: Ana
authors.initials: A
authors.lastname: Matos
authors.forename: Carlos
authors.initials: C
authors.lastname: Lopes
authors.forename: Rui
authors.initials: R
authors.lastname: Medeiros
mesh_terms: D003062:Codon; D005260:Female; D016158:Genes, p53; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011174:Portugal / Q000453:epidemiology; D012306:Risk; D002583:Uterine Cervical Neoplasms / Q000235:genetics*
chemical_list: D003062:Codon