title: Age-dependent effects of the 5-hydroxytryptamine-2a-receptor polymorphism (His452Tyr) on human memory.
abstract: A polymorphism (His452Tyr) of the 5-hydroxytryptamine (5-HT)2a receptor is associated with episodic memory in healthy young humans. Because 5-HT2a-receptor density decreases with increasing age, we tested whether the 5-HT2a receptor genotype effect on memory is influenced by age. We investigated the association of the His452Tyr genotype with memory performance in 622 healthy study participants aged from 18 to 90 years. In young to middle-aged participants, age significantly influenced genotype effects on episodic memory: the His452Tyr genotype exerted a significant influence on memory only in young participants. In the group of elderly cognitively healthy participants, the His452Tyr genotype did not affect memory performance. We conclude that age strongly modulates the effect of the 5-HT2a receptor polymorphism at residue 452 on episodic memory.
authors.affiliation: Division of Psychiatry Research, University of Zurich, Lenggstr. 31, 8029 Zurich, Switzerland. papas@bli.unizh.ch
authors.forename: Andreas
authors.initials: A
authors.lastname: Papassotiropoulos
authors.forename: Katharina
authors.initials: K
authors.lastname: Henke
authors.forename: Amanda
authors.initials: A
authors.lastname: Aerni
authors.forename: Daniel
authors.initials: D
authors.lastname: Coluccia
authors.forename: Esmeralda
authors.initials: E
authors.lastname: Garcia
authors.forename: Marc A
authors.initials: MA
authors.lastname: Wollmer
authors.forename: Kim-Dung
authors.initials: KD
authors.lastname: Huynh
authors.forename: Andreas U
authors.initials: AU
authors.lastname: Monsch
authors.forename: Hannes B
authors.initials: HB
authors.lastname: Stähelin
authors.forename: Christoph
authors.initials: C
authors.lastname: Hock
authors.forename: Roger M
authors.initials: RM
authors.lastname: Nitsch
authors.forename: Dominique J-F
authors.initials: DJ
authors.lastname: de Quervain
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D005260:Female; D005838:Genotype; D006639:Histidine / Q000235:genetics*; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D013223:Statistics as Topic; D013997:Time Factors; D014443:Tyrosine / Q000235:genetics*
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D014443:Tyrosine; D006639:Histidine