title: Genotoxicity and sister chromatid exchange in patients with myelodysplastic disorders.
abstract: In this study, we aimed to evaluate genotoxicity by sister chromatid exchange frequency in the peripheral lymphocytes of patients with myelodysplastic syndrome (MDS). The study population consisted of 16 patients (females/males:6/10; mean age: 61.68 +/- 13.08 years) diagnosed with "refractory anemia" according to FAB classification. The results were compared with an age- and sex-matched control group. The sister chromatid exchange frequency in the study group was found to be significantly higher than the control group (8.3 +/- 11 vs. 6.83 +/- 1.07, P=0.0046). We suggest that increased DNA damage, which is revealed by the increased sister chromatid exchange in the present study may play a role in the etiopathogenesis of MDS.
authors.affiliation: Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Medical Genetics, Capa- Fatih, Istanbul, Turkey. sozturk@istanbul.edu.tr
authors.forename: Sükrü
authors.initials: S
authors.lastname: Oztürk
authors.forename: Sükrü
authors.initials: S
authors.lastname: Palanduz
authors.forename: Kivanç
authors.initials: K
authors.lastname: Cefle
authors.forename: Gülçin
authors.initials: G
authors.lastname: Tutkan
authors.forename: Ali
authors.initials: A
authors.lastname: Uçur
authors.forename: Günçağ
authors.initials: G
authors.lastname: Dinçol
authors.forename: Meliha
authors.initials: M
authors.lastname: Nalçaci
authors.forename: Melih
authors.initials: M
authors.lastname: Aktan
authors.forename: Selim
authors.initials: S
authors.lastname: Yavuz
authors.forename: Reyhan Diz
authors.initials: RD
authors.lastname: Küçükkaya
mesh_terms: D000328:Adult; D000368:Aged; D004249:DNA Damage; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D012854:Sister Chromatid Exchange