title: Overexpression of CD10 and reduced MUC2 expression correlate with the development and progression of colorectal neoplasms.
abstract: There are two opposing theories of the natural history of colorectal neoplasm, adenoma-carcinoma sequence and de novo carcinogenesis. To elucidate the histogenesis of colorectal carcinoma, we investigated the expression of CD10, MUC2, MUC5AC, MUC6, and p53 in colorectal neoplasms. Sixty-seven morphologically distinct neoplastic specimens were divided into the following groups according to morphology: adenoma (groups A and B), protruded-type carcinoma (group C), superficial-type carcinoma with adenomatous component (group D), or superficial-type carcinomas without any adenomatous component (group E). Diagnoses of adenomas and carcinomas were based upon the Vienna classification of gastrointestinal epithelial neoplasia. The expression of CD10 in group E lesions was more intense than in the other groups. Regardless of morphology, MUC2 expression was significantly decreased in CD10-positive carcinomas, and the p53-positive rate was much higher in CD10-positive than in CD10-negative carcinomas. The overexpression of CD10 and reduced expression of MUC2 may be associated with the development and progression of colorectal carcinoma. A specific tendency was evident in superficial-type carcinomas without any adenomatous component (de novo carcinomas). These carcinomas are considered to be more aggressive than other morphologically distinct carcinomas.
authors.affiliation: Department of Pathology, Shiga University of Medical Science, Seta-Tsukinowa-Cho, Ohtsu, Shiga, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Iwase
authors.forename: Ryoji
authors.initials: R
authors.lastname: Kushima
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Mukaisho
authors.forename: Shoji
authors.initials: S
authors.lastname: Mitsufuji
authors.forename: Takeshi
authors.initials: T
authors.lastname: Okanoue
authors.forename: Takanori
authors.initials: T
authors.lastname: Hattori
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D055271:Mucin 5AC; D055262:Mucin-2; D055272:Mucin-6; D009077:Mucins / Q000096:biosynthesis*; D009361:Neoplasm Invasiveness; D015260:Neprilysin / Q000096:biosynthesis*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; C524625:MUC2 protein, human; C524678:MUC5AC protein, human; C524734:MUC6 protein, human; D055271:Mucin 5AC; D055262:Mucin-2; D055272:Mucin-6; D009077:Mucins; D016159:Tumor Suppressor Protein p53; D015260:Neprilysin