Axonal signals in central nervous system myelination, demyelination and remyelination.
Axonal signals are key players in central nervous system myelination. During development, the onset of myelination depends on a balance between positive and negative axonal signals. Among negative signals are inhibitory adhesion molecules that need to be removed from the cell surface for the myelination process to proceed. Positive signals necessary to initiate myelination consist of both interactions with specific adhesion molecules and electrical activity-induced release of promyelinating factors. In multiple sclerosis, demyelination induces major modifications of axonal surface components. The disruption of these factors might participate to the failure of the myelin repair process.
Coman
Irène
I
Biologie des Interactions Neurones/Glie, INSERM U-711, Paris, France.
Barbin
Gilles
G
Charles
Perrine
P
Zalc
Bernard
B
Lubetzki
Catherine
C
D000818:Animals; D001369:Axons / Q000473:pathology*; D002490:Central Nervous System / Q000378:metabolism / Q000473:pathology*; D003711:Demyelinating Diseases / Q000473:pathology*; D006801:Humans; D008954:Models, Biological; D009186:Myelin Sheath / Q000502:physiology*; D039842:Neural Cell Adhesion Molecule L1 / Q000378:metabolism; D009433:Neural Inhibition; D012794:Sialic Acids / Q000378:metabolism; D015398:Signal Transduction
D039842:Neural Cell Adhesion Molecule L1; D012794:Sialic Acids; C103469:polysialyl neural cell adhesion molecule