title: Chelation-controlled intermolecular alkene and alkyne hydroacylation: the utility of beta-thioacetal aldehydes.
abstract: [reaction: see text]. Beta-thioacetal-substituted aldehydes, which are conveniently prepared from the corresponding ynals, can be combined with a range of alkynes or electron-poor alkenes to deliver intermolecular hydroacylation adducts. The reactions employ [Rh(dppe)]ClO4 as a catalyst and are proposed to proceed via a chelated rhodium acyl intermediate. The thioacetal-containing products can be deprotected to the corresponding ketones or reduced to alkanes in good yields.
authors.affiliation: Department of Chemistry, University of Bath, Bath, BA2 7AY, UK. m.c.willis@bath.ac.uk
authors.forename: Michael C
authors.initials: MC
authors.lastname: Willis
authors.forename: Helen E
authors.initials: HE
authors.lastname: Randell-Sly
authors.forename: Robert L
authors.initials: RL
authors.lastname: Woodward
authors.forename: Gordon S
authors.initials: GS
authors.lastname: Currie