title: [Lymphadenectomy for testicular cancer. Diagnostic and prognostic significance as well as therapeutic benefit].
abstract: The rationale to perform retroperitoneal lymph node dissection (RPLND) in testicular cancer depends on the clinical stage and previous therapy. Thus, it can be performed either with diagnostic, prognostic, or therapeutic intention. In verified clinical stage I nonseminoma, RPLND provides one of three adjuvant options. To verify the clinical stage pathologically, surgery is done for diagnostic reasons, since CT scanning provides a false-negative staging in up to 30%. In higher stage lesions RPLND is a therapeutic procedure. The importance, however, of RPLND in clinical stage I nonseminoma is decreasing, since prognostic factors are available to stratify patients with either low or high risk for recurrence. Thus, these patients are selected for surveillance (low risk) or adjuvant chemotherapy (high risk). RPLND after chemotherapy is done for resection of residual tumor with a therapeutic intention. The histology of the residual mass is of prognostic importance and may help define further therapy. Resection of retroperitoneal metastases in patients with chemorefractory tumors is curative in about 25%.
authors.affiliation: Urologische Klinik, Universitätsklinikum Essen. susanne.krege@uni-essen.de
authors.forename: S
authors.initials: S
authors.lastname: Krege
authors.forename: H
authors.initials: H
authors.lastname: Rübben
mesh_terms: D002986:Clinical Trials as Topic; D006801:Humans; D008197:Lymph Node Excision / Q000379:methods*; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery*; D008207:Lymphatic Metastasis; D008297:Male; D009367:Neoplasm Staging; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D011300:Preoperative Care / Q000379:methods; D011379:Prognosis; D011468:Prostatectomy / Q000379:methods*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D013736:Testicular Neoplasms / Q000473:pathology* / Q000601:surgery*