Staphylococcus aureus: the search for novel targets.
In the UK, 20,000 cases of Staphylococcus aureus bacteraemia are reported each year, half of which are antibiotic resistant and approximately 4% are fatal, exemplifying a worldwide phenomenon of tremendous economic and human impact. Novel treatments and prophylaxis are urgently required to combat such a serious threat. A common goal in the postgenomic era is to identify new targets for drug intervention (using small molecules) and immunologicals. Several promising cellular targets are now being developed in the quest to control such a life-threatening pathogen.
García-Lara
Jorge
J
Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, UK, S10 2TN.
Masalha
Mahmud
M
Foster
Simon J
SJ
D001426:Bacterial Proteins / Q000235:genetics; D015195:Drug Design; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics / Q000472:pathogenicity
D001426:Bacterial Proteins