title: 4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17beta-hydroxysteroid dehydrogenase. Part 2. SAR.
abstract: 4,5-Disubstituted cis-pyrrolidinones were investigated as inhibitors of type II 17beta-hydroxysteroid dehydrogenase (17beta-HSD). Early structure-activity relationship patterns for this class of compounds are discussed.
authors.affiliation: Bayer Research Center, Bayer HealthCare Pharmaceuticals, 400 Morgan Lane, West Haven, CT 06516, USA. david.gunn.b@bayer.com
authors.forename: David
authors.initials: D
authors.lastname: Gunn
authors.forename: Christiana
authors.initials: C
authors.lastname: Akuche
authors.forename: Jeremy
authors.initials: J
authors.lastname: Baryza
authors.forename: Marie-Louise
authors.initials: ML
authors.lastname: Blue
authors.forename: Catherine
authors.initials: C
authors.lastname: Brennan
authors.forename: Ann-Marie
authors.initials: AM
authors.lastname: Campbell
authors.forename: Soongyu
authors.initials: S
authors.lastname: Choi
authors.forename: James
authors.initials: J
authors.lastname: Cook
authors.forename: Patricia
authors.initials: P
authors.lastname: Conrad
authors.forename: Brian
authors.initials: B
authors.lastname: Dixon
authors.forename: Jacques
authors.initials: J
authors.lastname: Dumas
authors.forename: Paul
authors.initials: P
authors.lastname: Ehrlich
authors.forename: Todd
authors.initials: T
authors.lastname: Gane
authors.forename: Ted
authors.initials: T
authors.lastname: Joe
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Johnson
authors.forename: Jerold
authors.initials: J
authors.lastname: Jordan
authors.forename: Richard
authors.initials: R
authors.lastname: Kramss
authors.forename: Peying
authors.initials: P
authors.lastname: Liu
authors.forename: Joan
authors.initials: J
authors.lastname: Levy
authors.forename: Derek
authors.initials: D
authors.lastname: Lowe
authors.forename: Ian
authors.initials: I
authors.lastname: McAlexander
authors.forename: Reina
authors.initials: R
authors.lastname: Natero
authors.forename: Anikó M
authors.initials: AM
authors.lastname: Redman
authors.forename: William
authors.initials: W
authors.lastname: Scott
authors.forename: Thomas
authors.initials: T
authors.lastname: Seng
authors.forename: Robert
authors.initials: R
authors.lastname: Sibley
authors.forename: Ming
authors.initials: M
authors.lastname: Wang
authors.forename: Yamin
authors.initials: Y
authors.lastname: Wang
authors.forename: Jill
authors.initials: J
authors.lastname: Wood
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D015067:17-Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D011760:Pyrrolidinones / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D011760:Pyrrolidinones; D015067:17-Hydroxysteroid Dehydrogenases; C044256:3 (or 17)-beta-hydroxysteroid dehydrogenase