Temporal control of cell cycle gene expression mediated by E2F transcription factors.
Various studies now point to the role of cooperative transcription factor interactions as a mechanism to achieve the necessary specificity in promoter recognition. An example can be seen in the action of E2F proteins where interactions with other transcription factors not only provides this general specificity but also the specificity that distinguishes function of the individual E2F proteins. This includes both the activation and repression functions of E2Fs and has now also been extended to the control of G2/M regulated genes in addition to the G1/S E2F targets. These studies further highlight events linking the control of G1/S genes with G2/M, providing a mechanism to achieve the temporal control of gene expression as cells move through the cell cycle.
Zhu
Wencheng
W
Duke Institute for Genome Sciences and Policy, Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Giangrande
Paloma H
PH
Nevins
Joseph R
JR
D000818:Animals; D002453:Cell Cycle / Q000235:genetics* / Q000502:physiology; D002455:Cell Division / Q000235:genetics / Q000502:physiology; D050684:E2F Transcription Factors / Q000235:genetics / Q000502:physiology*; D016193:G1 Phase / Q000235:genetics / Q000502:physiology; D016195:G2 Phase / Q000235:genetics / Q000502:physiology; D005786:Gene Expression Regulation; D018816:Genes, cdc; D006801:Humans; D011401:Promoter Regions, Genetic; D016196:S Phase / Q000235:genetics / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology; D014158:Transcription, Genetic
D050684:E2F Transcription Factors; D014157:Transcription Factors