title: Impact of p53 aberration on the progression of Adult T-cell Leukemia/Lymphoma.
abstract: Based on statistical analysis of its age-dependent occurrence, a multi-step carcinogenesis model has been proposed for Adult T-cell Leukemia/Lymphoma (ATLL). We have previously reported that the deletion of the p16 gene is a key event in ATLL progression. In the current study, we report for the first time that the aberrations of p16 and p53 are mutually exclusive in ATLL and either of the two events is sufficient for the ATLL progression. More than half of the patients had one of the two aberrations, and both aberrations emerged as significant markers for a poor prognosis.
authors.affiliation: Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tawara
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Hogerzeil
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Yamada
authors.forename: Yumi
authors.initials: Y
authors.lastname: Takasaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Soda
authors.forename: Hiroo
authors.initials: H
authors.lastname: Hasegawa
authors.forename: Ken
authors.initials: K
authors.lastname: Murata
authors.forename: Shuichi
authors.initials: S
authors.lastname: Ikeda
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Imaizumi
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Sugahara
authors.forename: Kazuto
authors.initials: K
authors.lastname: Tsuruda
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Tsukasaki
authors.forename: Masao
authors.initials: M
authors.lastname: Tomonaga
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hirakata
authors.forename: Shimeru
authors.initials: S
authors.lastname: Kamihira
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics*; D002869:Chromosome Aberrations; D018450:Disease Progression; D005260:Female; D019942:Genes, p16; D016158:Genes, p53; D006801:Humans; D015458:Leukemia, T-Cell / Q000235:genetics*; D016399:Lymphoma, T-Cell / Q000235:genetics*; D008297:Male; D018807:Polymorphism, Single-Stranded Conformational; D011379:Prognosis; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D014408:Biomarkers, Tumor