The rhodium catalyzed three-component reaction of diazoacetates, titanium(IV) alkoxides and aldehydes.
The rhodium(II)-catalyzed three-component reaction of diazoacetates, titanium alkoxides and aldehydes is shown to give alpha-alkoxyl-beta-hydroxyl acid derivatives; the novel C-C bond formation reaction is proposed to occur through oxonium ylides derived from diazo compounds and titanium alkoxides, and followed by intermolecular trapping by aldehydes.
Lu
Chong-Dao
CD
Key Laboratory for Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China.
Liu
Hui
H
Chen
Zhi-Yong
ZY
Hu
Wen-Hao
WH
Mi
Ai-Qiao
AQ
D000085:Acetates / Q000138:chemical synthesis / Q000737:chemistry*; D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry*; D001391:Azo Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D008968:Molecular Conformation; D009942:Organometallic Compounds; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism; D014025:Titanium / Q000737:chemistry*
D000085:Acetates; D000447:Aldehydes; D001391:Azo Compounds; D009942:Organometallic Compounds; C102815:titanium isopropoxide; D014025:Titanium; D012238:Rhodium