title: [Platelet inhibition and activation. Mechanisms and clinical implications].
abstract: The sensitivity to activation of platelets is part of the delicate equilibrium differentiating hemostasis from thrombosis. Under physiological conditions it is maintained by downregulating platelet activity and removing agonists. Under pathologic conditions the clinician tries to restore this equilibrium with pharmaceutical drugs. The results obtained by such treatments are steadily improving but there is still need for better knowledge of the mechanisms involved and for alternative inhibitors.
authors.affiliation: Klinik und Poliklinik für Hämatologie und Hämatologisches Zentrallabor der Universität, Inselspital, Bern, Schweiz.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Alberio
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Clemetson
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000276:immunology*; D006801:Humans; D018448:Models, Immunological; D015539:Platelet Activation / Q000187:drug effects / Q000276:immunology*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D013927:Thrombosis / Q000503:physiopathology* / Q000517:prevention & control*
chemical_list: D010975:Platelet Aggregation Inhibitors