title: Clinical and immunogenetic correlates of abacavir hypersensitivity.
abstract: A patch test (PT) may be useful in defining true abacavir hypersensitivity syndrome (AHS). Seven previously PT-positive patients remote from the original AHS were shown to have robust 24 h responses, supporting PT durability. HLA-B*5701 was present in all seven PT-positive versus one of 11 controls tolerating abacavir (P < 0.001). Five of seven PT (71%) versus one of 11 controls (9%) (P = 0.005) showed significant abacavir-specific CD8 proliferation, suggesting a direct role for HLA-B*5701-restricted CD8 cells in the pathophysiology of AHS.
authors.affiliation: British Columbia Centre for Excellence in HIV/AIDS, Vancouver, University of British Columbia, Canada.
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: Phillips
authors.forename: Gavin A
authors.initials: GA
authors.lastname: Wong
authors.forename: Rupert
authors.initials: R
authors.lastname: Kaul
authors.forename: Kamnoosh
authors.initials: K
authors.lastname: Shahabi
authors.forename: David A
authors.initials: DA
authors.lastname: Nolan
authors.forename: Sandra R
authors.initials: SR
authors.lastname: Knowles
authors.forename: Annalise M
authors.initials: AM
authors.lastname: Martin
authors.forename: Simon A
authors.initials: SA
authors.lastname: Mallal
authors.forename: Neil H
authors.initials: NH
authors.lastname: Shear
mesh_terms: D019380:Anti-HIV Agents / Q000009:adverse effects*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D015224:Dideoxynucleosides / Q000009:adverse effects*; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D020022:Genetic Predisposition to Disease; D015235:HLA-B Antigens / Q000032:analysis; D006801:Humans; D010328:Patch Tests / Q000379:methods; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects*; D000099227:Abacavir
chemical_list: D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D015235:HLA-B Antigens; D018894:Reverse Transcriptase Inhibitors; D000099227:Abacavir; C484830:HLA-B*57:01 antigen