title: Effect of the anticancer drug oracin on mouse liver topoisomerases I and II.
abstract: The inhibitory effect of oracin on the activities of topoisomerases I and II isolated from the nuclei of mice liver tissue was studied. This drug showed a 100% inhibitory effect at 5 microM and 50% inhibition at 1 microM on topoisomerase II activity, while the activity of topoisomerase I at these concentrations was not inhibited.
authors.affiliation: Department of Molecular Biology, Comenius University, Mlynskádolina B-2, 84215 Bratislava, Slovakia. stuchlik@fns.uniba.sk
authors.forename: Stanislav
authors.initials: S
authors.lastname: Stuchlík
authors.forename: Ján
authors.initials: J
authors.lastname: Turna
authors.forename: Milan
authors.initials: M
authors.lastname: Miko
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002467:Cell Nucleus / Q000187:drug effects / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004983:Ethanolamines / Q000494:pharmacology*; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000494:pharmacology*; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051379:Mice; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D004983:Ethanolamines; D007546:Isoquinolines; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; C103439:oracine