title: Sensorineural hearing loss in patients with cerebral palsy after asphyxia and hyperbilirubinemia.
abstract: The location of lesions causing hearing loss in patients with cerebral palsy due to asphyxia or neonatal hyperbilirubinemia has remained unclear. We performed behavioral audiometry, distortion product otoacoustic emission (DPOAE) and auditory brainstem evoked response (ABR) in six patients with cerebral palsy due to asphyxia or neonatal hyperbilirubinemia in order to determine the lesion location causing their hearing impairment. In all cases, behavioral audiometry revealed a threshold elevation of 50-75 dB and ABR were no response. DPOAE were totally absent in five patients and normal in one patient. Our study suggests that lesions causing hearing loss potentially include the organ of Corti especially at the outer hair cells and the cochlear nerve.
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. gakutaikyo@yahoo.co.jp
authors.forename: Masaki
authors.initials: M
authors.lastname: Sano
authors.forename: Kimitaka
authors.initials: K
authors.lastname: Kaga
authors.forename: Eiji
authors.initials: E
authors.lastname: Kitazumi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kodama
mesh_terms: D000293:Adolescent; D000328:Adult; D001238:Asphyxia Neonatorum / Q000150:complications* / Q000503:physiopathology; D001300:Audiometry, Evoked Response; D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold / Q000502:physiology; D002547:Cerebral Palsy / Q000150:complications* / Q000209:etiology / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D003056:Cochlear Nerve / Q000473:pathology; D018072:Hair Cells, Auditory, Outer / Q000473:pathology; D006319:Hearing Loss, Sensorineural / Q000209:etiology* / Q000473:pathology; D006801:Humans; D006932:Hyperbilirubinemia / Q000150:complications* / Q000503:physiopathology; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D009925:Organ of Corti / Q000473:pathology; D017084:Otoacoustic Emissions, Spontaneous