title: Virus-associated hemophagocytic syndrome in an international traveler as a differential diagnosis of SARS.
abstract: During the epidemic of severe acute respiratory syndrome in 2003, a 27-year- old Japanese woman presented a high fever and acute respiratory distress with pulmonary infiltrates after traveling to a high-risk area. An alternative diagnosis was made as Epstein-Barr virus-associated hemophagocytic syndrome, based on the proliferation of macrophages with hemophagocytosis in the bone marrow and Epstein-Barr viral marker profiles. Virus-associated hemophagocytic syndrome in an international traveler should be included in the differential diagnosis of severe acute respiratory syndrome.
authors.affiliation: Department of Internal Medicine, Tokai University School of Medicine, Isehara.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishii
authors.forename: Satomi
authors.initials: S
authors.lastname: Asai
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Kenji
authors.initials: K
authors.lastname: Eguchi
authors.forename: Hayato
authors.initials: H
authors.lastname: Miyachi
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000276:immunology; D001707:Biopsy, Needle; D001853:Bone Marrow / Q000473:pathology; D004279:DNA, Viral / Q000235:genetics; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis* / Q000821:virology; D005260:Female; D005500:Follow-Up Studies; D016679:Genome, Viral; D005938:Glucocorticoids / Q000627:therapeutic use; D004854:Herpesvirus 4, Human / Q000187:drug effects / Q000235:genetics / Q000276:immunology; D015616:Histiocytosis, Non-Langerhans-Cell / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use; D016133:Polymerase Chain Reaction; D013902:Radiography, Thoracic; D045169:Severe Acute Respiratory Syndrome / Q000175:diagnosis*; D013785:Thailand; D014057:Tomography, X-Ray Computed; D014195:Travel
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; D005938:Glucocorticoids; D008775:Methylprednisolone