A sequential palladium-catalyzed alder-ene-reductive amination reaction.
[reaction: see text]. Alkyne allyl alcohols are readily transformed into beta-amino ethyl alkylidene tetrahydrofurans or beta-amino ethyl alkylidene pyrrolidines in a Pd-catalyzed cycloisomerization-reductive amination sequence with remarkable chemoselectivity leaving benzyl groups and trisubstituted double bonds intact.
Kressierer
Christoph J
CJ
Organisch-Chemisches Institut der Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 270, D-69120 Heidelberg, Germany.
Müller
Thomas J J
TJ