title: Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels.
abstract: Elevated plasma levels of C-reactive protein (CRP), an inflammation-sensitive marker, have emerged as an important predictor of future cardiovascular disease and metabolic abnormalities in apparently healthy men and women. Here, we performed a systematic survey of common nucleotide variation across the genomic region encompassing the CRP gene locus. Of the common single-nucleotide polymorphisms (SNPs) identified, several in the CRP promoter region are strongly associated with CRP levels in a large cohort study of cardiovascular risk in European American and African American young adults. We also demonstrate the functional importance of these SNPs in vitro.
authors.affiliation: Department of Genome Sciences, University of Washington, Seattle, WA, USA. csc47@u.washington.edu
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Carlson
authors.forename: Shelley Force
authors.initials: SF
authors.lastname: Aldred
authors.forename: Philip K
authors.initials: PK
authors.lastname: Lee
authors.forename: Russell P
authors.initials: RP
authors.lastname: Tracy
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Schwartz
authors.forename: Mark
authors.initials: M
authors.lastname: Rieder
authors.forename: Kiang
authors.initials: K
authors.lastname: Liu
authors.forename: O Dale
authors.initials: OD
authors.lastname: Williams
authors.forename: Carlos
authors.initials: C
authors.lastname: Iribarren
authors.forename: E Cora
authors.initials: EC
authors.lastname: Lewis
authors.forename: Myriam
authors.initials: M
authors.lastname: Fornage
authors.forename: Eric
authors.initials: E
authors.lastname: Boerwinkle
authors.forename: Myron
authors.initials: M
authors.lastname: Gross
authors.forename: Cashell
authors.initials: C
authors.lastname: Jaquish
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Nickerson
authors.forename: Richard M
authors.initials: RM
authors.lastname: Myers
authors.forename: David S
authors.initials: DS
authors.lastname: Siscovick
authors.forename: Alexander P
authors.initials: AP
authors.lastname: Reiner
mesh_terms: D000293:Adolescent; D001483:Base Sequence; D002097:C-Reactive Protein / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic
chemical_list: D002097:C-Reactive Protein