Regulative actions of the Chinese drugs for tonifying the kidney on gene expression of the hypothalamic GnRH, pituitary FSH, LH and osteoblastic BGP.
It is found that the drugs for nourishing yin to reduce pathogenic fire can significantly down-regulate, and the drugs for tonifying the kidney to replenish essence can up-regulate mRNA expression of the hypothalamic GnRH, pituitary FSH, LH and osteoblastic BGP, indicating that the Chinese drugs for tonifying the kidney can regulate gene expression of the hypothalamic GnRH, pituitary FSH, LH, and osteoblastic BGP, which is possibly one of the main mechanisms of the Chinese drug for tonifying the kidney, regulating ephebic development process andimproving skeletal development in sexual precocity children.
Cai
Depei
D
Pediatric Hospital Affiliated to Shanghai Medical University, Shanghai 200032, China.
Zhang
Wei
W
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000096:biosynthesis / Q000235:genetics; D007987:Gonadotropin-Releasing Hormone / Q000096:biosynthesis* / Q000235:genetics; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D007335:Insulin-Like Growth Factor II; D007986:Luteinizing Hormone / Q000096:biosynthesis / Q000235:genetics; D010006:Osteoblasts / Q000378:metabolism; D010906:Pituitary Hormone-Releasing Hormones / Q000096:biosynthesis* / Q000235:genetics; D011506:Proteins / Q000378:metabolism*; D011629:Puberty, Precocious / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D016710:Yin Deficiency / Q000378:metabolism
D004365:Drugs, Chinese Herbal; C035170:IGF2 protein, human; D010906:Pituitary Hormone-Releasing Hormones; D011506:Proteins; D012333:RNA, Messenger; D007987:Gonadotropin-Releasing Hormone; D007335:Insulin-Like Growth Factor II; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone