title: [Interrelations between sleep and the immune status].
abstract: BACKGROUND
  The idea of the healing effects of the sleep over the disease is quite extended. Besides, the sleep and the circadian rhythms cause deep changes on the immune function. Reciprocally, the sleep also suffers deep changes when the immune system is challenged during an external aggression.
  
  
  METHODS
  This review shows some of the data supporting both observations. From the relationships between the sleep and the immune system, it has been proposed that one function of sleep is just to support the immune defense. However, an important fraction of the relationships between sleep and immune function might be a response to the stress produced both during the sleep disorders and when the organism activates the immune defense. Moreover, the epidemiological evidence only shows negligible results when contrasting the amount of sleep and the life expectancy.
  
  
  CONCLUSIONS
  It seems thus probable that the relationships between sleep and immune function are only a reflect of additional factors, such as stress, which cause deep changes in sleep and immunity.
authors.affiliation: Department of Physiology, Universidad de Extremadura, Badajoz, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Barriga-Ibars
authors.forename: A B
authors.initials: AB
authors.lastname: Rodríguez-Moratinos
authors.forename: S
authors.initials: S
authors.lastname: Esteban
authors.forename: R V
authors.initials: RV
authors.lastname: Rial
mesh_terms: D000818:Animals; D001831:Body Temperature; D002940:Circadian Rhythm / Q000502:physiology*; D006801:Humans; D007107:Immune System / Q000502:physiology*; D008017:Life Expectancy; D011598:Psychoneuroimmunology; D012890:Sleep / Q000276:immunology*; D013315:Stress, Psychological / Q000276:immunology