title: Peritoneal taurolidine lavage in children with localised peritonitis due to appendicitis.
abstract: Despite aggressive surgical treatment, rational antibiotic therapy, and modern intensive care, generalised peritonitis remains a major threat in the paediatric age group. Several adjuvant strategies such as peritoneal saline lavage and peritoneal drainage have been utilised. Taurolidine, derived from the amino acid taurine, has bactericidic, antiendotoxic, and antiinflammatory properties. It has been introduced previously for intraoperative peritoneal lavage in treating peritonitis in adults. The aim of our study was to evaluate the effect of peritoneal taurolidine lavage on the clinical course and serological inflammation markers in children with perforated appendicitis and localised peritonitis. A series of 27 children presenting with appendicitis between January 1999 and July 2001 were included in the study after parental informed consent. All patients underwent open appendectomy. Taurolidine peritoneal lavage was applied in 15 randomly selected children (eight girls and seven boys; mean age 10 years and 10 months). Twelve children received saline peritoneal lavage and served as the control group (six girls and six boys; mean age 9 years and 7 months). Blood was taken preoperatively and on postoperative days 1, 3, 7, and 14. Full blood cell count, C-reactive protein, endotoxin, interleukin-1, interleukin-6, soluble interleukin-2 receptor, tumour necrosis factor alpha, and procalcitonin were investigated to evaluate the serological course of inflammation. Both groups initially presented with severe inflammation as evidenced clinically and serologically. The clinical postoperative course was uneventful in 13/15 patients in the treatment group and 10/12 patients in the control group. The remaining patients presented complications: intraperitoneal abscess or early postoperative bowel obstruction. With regard to the serological inflammatory parameters, no significant differences were found between the two groups except for the soluble interleukin-2-receptor on the 7th postoperative day. In conclusion, the expected reduction of endotoxin levels and inflammatory activity in the treatment group was not evident. A significant advantage of adjuvant peritoneal taurolidine lavage in the surgical therapy of children with localised peritonitis due to appendicitis could not be shown in our study.
authors.affiliation: Department of Paediatric Surgery, University of Leipzig, Oststrasse 21-25, 04317 Leipzig, Germany. schneia@medizin.uni-leipzig.de
authors.forename: Axel
authors.initials: A
authors.lastname: Schneider
authors.forename: Ulrich
authors.initials: U
authors.lastname: Sack
authors.forename: Karin
authors.initials: K
authors.lastname: Rothe
authors.forename: Joachim
authors.initials: J
authors.lastname: Bennek
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001064:Appendicitis / Q000150:complications*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D010538:Peritonitis / Q000188:drug therapy* / Q000209:etiology; D015375:Receptors, Interleukin-2 / Q000097:blood; D013654:Taurine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013829:Thiadiazines / Q000627:therapeutic use*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D000890:Anti-Infective Agents; D015375:Receptors, Interleukin-2; D013829:Thiadiazines; D014409:Tumor Necrosis Factor-alpha; D013654:Taurine; C012566:taurolidine