title: Lymphocyte subsets, TNF alpha and interleukin-4 levels in treated and untreated subacute sclerosing panencephalitis patients.
abstract: Immunologic studies in relation to clinical status might help to understand the pathogenesis of subacute sclerosing panencephalitis (SSPE) and the effect of treatment. We measured lymphocyte subsets and intracellular TNFalpha and interleukin-4 levels in peripheral blood in SSPE patients. Patients had elevated percentages of CD8+ cells compared to age-matched control children. Rapidly progressive course was associated with increased CD4+ cells. Treatment with interferons and inosiplex altered the percentage of CD3+, CD4+ and CD19+ cells. TNFalpha and interleukin-4 levels had no correlation with course or treatment. The proportions of lymphocyte subsets appear to have a role in the evolution or manifestations of SSPE, if not in the pathogenesis.
authors.affiliation: Hacettepe University Faculty of Medicine, Department of Pediatric Neurology, Ankara, 06100, Turkey. banlar@hacettepe.edu.tr
authors.forename: Banu
authors.initials: B
authors.lastname: Anlar
authors.forename: Alev
authors.initials: A
authors.lastname: Guven
authors.forename: Gulsen
authors.initials: G
authors.lastname: Köse
authors.forename: Hamza
authors.initials: H
authors.lastname: Okur
authors.forename: Ozgü
authors.initials: O
authors.lastname: Kose
authors.forename: Omer F
authors.initials: OF
authors.lastname: Aydin
authors.forename: Nimet
authors.initials: N
authors.lastname: Kabakus
authors.forename: Sakir
authors.initials: S
authors.lastname: Altunbasak
authors.forename: Ozlem
authors.initials: O
authors.lastname: Herguner
authors.forename: Mujgan
authors.initials: M
authors.lastname: Sonmez
authors.forename: Ayse
authors.initials: A
authors.lastname: Serdaroglu
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007542:Inosine Pranobex / Q000627:therapeutic use; D007372:Interferons / Q000627:therapeutic use; D015847:Interleukin-4 / Q000097:blood*; D016131:Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism*; D008297:Male; D013344:Subacute Sclerosing Panencephalitis / Q000188:drug therapy* / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D014409:Tumor Necrosis Factor-alpha; D015847:Interleukin-4; D007372:Interferons; D007542:Inosine Pranobex