Association of catechol-O-methyltransferase with smoking cessation in two independent studies of women.
OBJECTIVE
The Val108/158Met polymorphism in the gene that encodes COMT, a dopamine metabolizing enzyme, results in a three- to four-fold reduction in COMT activity. To determine if the lower activity Met allele of COMT was associated with smoking cessation in women, we used two independent studies: a population-based case--control study and a nicotine replacement clinical trial.


RESULTS
In the case--control study, women with two Met alleles were significantly more likely to be ex-smokers than current smokers [OR=1.82, 95% CI (1.05, 3.17), P=0.03]. In the nicotine replacement clinical trial, among women, the Met/Met genotype was associated with a higher probability of smoking cessation based on both point prevalence and prolonged abstinence outcomes [OR=2.96, 95% CI (1.07, 8.14), P=0.04; OR=3.23, 95% CI (1.13, 9.20), P=0.03, respectively].


CONCLUSIONS
This first report of a significant association between COMT Val108/158Met and smoking cessation suggests that COMT variation has an effect on smoking behavior in women.
Colilla
Susan
S
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Lerman
Caryn
C
Shields
Peter G
PG
Jepson
Christopher
C
Rukstalis
Margaret
M
Berlin
Jesse
J
DeMichele
Angela
A
Bunin
Greta
G
Strom
Brian L
BL
Rebbeck
Timothy R
TR
D000368:Aged; D016022:Case-Control Studies; D002394:Catechol O-Methyltransferase / Q000378:metabolism*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009538:Nicotine / Q000008:administration & dosage; D016540:Smoking Cessation
D009538:Nicotine; D002394:Catechol O-Methyltransferase