[Immunologic characteristics of tumor-derived vascular endothelial cells].
Tumor vessel plays an important role in development of tumor, because they supply tumor not only nutrition but also a way of metastasis. Since tumor-derived vascular endothelial cells chronically emerge in tumor microenvironment, their phenotypes and functions have significantly changed, including some immunologic characteristics, such as down-regulated adhesion molecules, diminished leukocyte-endothelium interactions, impaired antigen presentation, enhanced resistant activity to free radicals, and synthesis of a great amount of extracellular matrix. Because tumor-derived vascular endothelial cell is the first barrier for immune cells and immune drugs to enter tumor tissue, these changes of immunologic characteristics of tumor- derived vascular endothelial cells may be related to the mechanisms of tumor cells escaping from host's immune surveillance and immune killing. This review summarized the immunologic characteristics of tumor-derived vascular endothelial cells, and analyzed the relationship between these characteristics and tumor immune escape.
Zhang
Wen-Jian
WJ
Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, P. R. China. lou.j@mail.com.
Wu
Lian-Qiu
LQ
Ye
Li-Ya
LY
Lou
Jin-Ning
JN
D000818:Animals; D017951:Antigen Presentation; D018952:Antigens, CD34 / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D015536:Down-Regulation; D042783:Endothelial Cells / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D016023:Integrins / Q000378:metabolism; D009369:Neoplasms / Q000276:immunology / Q000473:pathology*; D009569:Nitric Oxide / Q000378:metabolism; D019087:Selectins / Q000378:metabolism; D019139:Tumor Escape
D018952:Antigens, CD34; D015815:Cell Adhesion Molecules; D016023:Integrins; D019087:Selectins; D009569:Nitric Oxide