title: Clofazimine as elective treatment for granulomatous cheilitis.
abstract: Cheilitis granulomatosa (CG) is a rare, idiopathic inflammatory disorder that usually affects young adults and clinically is characterized by diffuse, non-tender, soft to firm swelling of one or both lips. A variant of granulomatous cheilitis is Melkersson-Rosenthal syndrome when associated with facial paralysis and furrowed tongue. Several treatments have been used with variable success. We report 3 cases of GC treated with oral clofazimine 100 to 200 mg daily for 3 to 6 months obtaining regression of lesions in all treated cases. Hyperpigmentation and elevation of liver enzymes were observed as side effects.
authors.affiliation: Department of Dermatology, Virgen del Rocio University Hospital, Seville, Spain.
authors.forename: Lourdes Rodríguez
authors.initials: LR
authors.lastname: Fdez-Freire
authors.forename: Amalia
authors.initials: A
authors.lastname: Serrano Gotarredona
authors.forename: Jose
authors.initials: J
authors.lastname: Bernabeu Wittel
authors.forename: Agueda
authors.initials: A
authors.lastname: Pulpillo Ruiz
authors.forename: Rocío
authors.initials: R
authors.lastname: Cabrera
authors.forename: Manuel
authors.initials: M
authors.lastname: Navarrete Ortega
authors.forename: Julián
authors.initials: J
authors.lastname: Conejo-Mir
mesh_terms: D000328:Adult; D000368:Aged; D002991:Clofazimine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008556:Melkersson-Rosenthal Syndrome / Q000188:drug therapy* / Q000473:pathology
chemical_list: D002991:Clofazimine