title: Regional cerebral blood flow deficits in mild Alzheimer's disease using high resolution single photon emission computerized tomography.
abstract: In spite of its wide availability, single photon emission computerized tomography (SPECT) scanning is uncommonly used in the assessment of Alzheimer's disease (AD) and related dementias. In light of recent advances in scanning protocols and image analysis, SPECT needs to be re-examined as a tool in the diagnosis of dementia. A total of 18 subjects with early AD and 10 healthy elderly control subjects were examined with high resolution SPECT during the performance of a simple word discrimination task. SPECT images were coregistered with individual magnetic resonance imaging scans, allowing delineation of predetermined neuroanatomical Regions of Interest (ROI). There was a gradation of regional cerebral blood flow (rCBF) values in both groups, with the lowest values being in the hippocampus and the highest in the striatum, thalamus and cerebellum. Compared to healthy controls, AD subjects demonstrated lower relative rCBF in parietal and prefrontal cortices. Analysis of individual ROI demonstrated bilateral reduction of rCBF in prefrontal poles, posterior temporal and anterior parietal cortex, and unilateral reduction of rCBF in left dorsolateral prefrontal cortex, right posterior parietal cortex and the left cingulate body. There were no significant differences for hippocampal, occipital or basal ganglia rCBF. Discriminant function analysis indicated that rCBF in the prefrontal polar regions achieved the best classification of cases. SPECT has utility in the diagnostic assessment of AD if standardized and semiquantitative techniques are used.
authors.affiliation: School of Psychiatry, University of New South Wales, Sydney, Australia. J.Trollor@unsw.edu.au
authors.forename: Julian N
authors.initials: JN
authors.lastname: Trollor
authors.forename: Perminder S
authors.initials: PS
authors.lastname: Sachdev
authors.forename: Walter
authors.initials: W
authors.lastname: Haindl
authors.forename: Henry
authors.initials: H
authors.lastname: Brodaty
authors.forename: Wei
authors.initials: W
authors.lastname: Wen
authors.forename: Brenda M
authors.initials: BM
authors.lastname: Walker
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003071:Cognition / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000502:physiology; D012959:Socioeconomic Factors; D015899:Tomography, Emission-Computed, Single-Photon