title: Cyclolignans from Scyphocephalium ochocoa via high-throughput natural product chemistry methods.
abstract: Two 2,7'-cyclolignans, ocholignans A and B, were obtained as mass-limited samples from Scyphocephalium ochocoa via high-throughput natural products chemistry methods. The rapid structure elucidation of each compound was primarily facilitated by NMR data acquisition using a capillary-scale NMR probe, CapNMR probe. Ocholignan A was found to possess significant in vitro antibacterial activity against Gram-positive bacteria methicillin-resistant Staphylococcus aureus ATCC 33591 and S. aureus 78-13607A with a MIC of 16 microg/mL, respectively.
authors.affiliation: Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc., 11199 Sorrento Valley Road, Suite H, San Diego, CA 92121, USA. jhu@sequoiasciences.com
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Hu
authors.forename: Eliane
authors.initials: E
authors.lastname: Garo
authors.forename: Hye-Dong
authors.initials: HD
authors.lastname: Yoo
authors.forename: Peadar A
authors.initials: PA
authors.lastname: Cremin
authors.forename: Matt G
authors.initials: MG
authors.lastname: Goering
authors.forename: Mark
authors.initials: M
authors.lastname: O'Neil-Johnson
authors.forename: Gary R
authors.initials: GR
authors.lastname: Eldridge
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D026324:Myristicaceae / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D017705:Lignans; C503017:ocholignan A; C503016:ocholignan B