Relationship between Schistosoma japonicum and nutritional status among children and young adults in Leyte, the Philippines.
The objectives of this study were 1) to provide more accurate estimates of the relationship between Schistosoma japonicum infection and both protein energy malnutrition (PEM) and anemia through better adjustment for potential confounders such as socioeconomic status (SES) and geo-helminth infections and 2) to assess the role of occult blood loss in mediating S. japonicum-associated anemia. We examined cross-sectionally 729 individuals (86.7% S. japonicum-infected and 13.3% S. japonicum-uninfected) aged 7-30 years in Leyte, The Philippines. The main outcome measures were height-for-age Z-score (HAZ), body-mass-index Z-score (BMIZ), triceps skinfold Z-score, hemoglobin, and fecal occult blood loss. Multivariate models were created to assess the relationship between S. japonicum infection and nutritional status after adjusting for age, gender, other helminths, and SES. After controlling for confounders, intensity of S. japonicum infection was inversely related to hemoglobin in all age groups (P < 0.0001) and HAZ among children </= 12 years (P = 0.03), but not to BMIZ (P = 0.52) or triceps skinfold Z-score (P = 0.11). Individuals with high-intensity S. japonicum infection were 3.5 times more likely to have occult blood in the stool. Adjustment for occult blood did not attenuate the relationship between S. japonicum and hemoglobin, suggesting other mechanisms are involved. Adjustment for SES allows more accurate assessment of the relationship between S. japonicum and both PEM and anemia. Exploration of the mechanisms of S. japonicum-associated anemia suggests that processes other than extracorporeal blood loss, such as anemia or inflammation, may be involved.
Friedman
Jennifer F
JF
International Health Institute, Brown University, Providence, Rhode Island 02912, USA. jennifer_friedman@brown.edu
Kanzaria
Hemal K
HK
Acosta
Luz P
LP
Langdon
Gretchen C
GC
Manalo
Daria L
DL
Wu
Haiwei
H
Olveda
Remigio M
RM
McGarvey
Stephen T
ST
Kurtis
Jonathan D
JD
D000293:Adolescent; D000328:Adult; D000740:Anemia / Q000469:parasitology; D002648:Child; D002664:Child Nutritional Physiological Phenomena; D003430:Cross-Sectional Studies; D004032:Diet; D005243:Feces / Q000469:parasitology; D005260:Female; D006130:Growth Disorders / Q000469:parasitology; D006801:Humans; D008297:Male; D009752:Nutritional Status / Q000502:physiology*; D010270:Parasite Egg Count; D010679:Philippines; D012554:Schistosomiasis japonica / Q000503:physiopathology*