Molecular mechanisms of hormonal activity. II. Kinase systems. Systems with intracellular receptors. Transactivation of STS.
Hormone receptors and other components, functional mechanisms, and biological role of analyzed signal transduction systems (STS) are described. The recently revealed module principle of the structure and STS transactivation providing diversity and plasticity of regulation are highlighted. STS activities are significantly changed in many diseases. Novel promising pharmaceuticals targeted to certain components of STS increase in number from year to year. The data published by the beginning of January 2004 are summarized in this review.
Kulinsky
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VI
Department of Biochemistry, Irkutsk State Medical University, 664003 Irkutsk, Russia. kulinsky@pp.irkutsk.ru
Kolesnichenko
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LS
D000818:Animals; D006728:Hormones / Q000378:metabolism; D006801:Humans; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*; D015290:Second Messenger Systems / Q000502:physiology; D015398:Signal Transduction; D015533:Transcriptional Activation
D006728:Hormones; D018160:Receptors, Cytoplasmic and Nuclear; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases