title: Formation of 4-aminopyrimidines via the trimerization of nitriles using focused microwave heating.
abstract: A series of substituted aliphatic nitriles have been trimerized to their corresponding pyrimidine structures under solvent-free conditions in the presence of catalytic quantities of potassium tert-butoxide using a focused microwave reactor. Multigram quantities of the corresponding 4-aminopyrimidines have been prepared in high yields and purity following a simple and scaleable protocol.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
authors.forename: Ian R
authors.initials: IR
authors.lastname: Baxendale
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
mesh_terms: D000440:Butanols / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D009682:Magnetic Resonance Spectroscopy; D008872:Microwaves; D009570:Nitriles / Q000737:chemistry*; D011743:Pyrimidines / Q000138:chemical synthesis*; D013678:Technology, Pharmaceutical; D013696:Temperature
chemical_list: D000440:Butanols; D009570:Nitriles; D011743:Pyrimidines; C034821:4-aminopyrimidine; C077664:tert-butoxide, potassium