The yeast Mediator complex and its regulation.
The Mediator complex acts as a bridge, conveying regulatory information from enhancers and other control elements to the basal RNA polymerase II transcription machinery. Mediator is required for the regulated transcription of nearly all RNA polymerase II-dependent genes in Saccharomyces cerevisiae, and post-translational modifications of specific Mediator subunits can affect global patterns of gene transcription.
Björklund
Stefan
S
Department of Medical Biochemistry, Umeå University, S-901 87 Umeå, Sweden. stefan.bjorklund@medchem.umu.se
Gustafsson
Claes M
CM
D000818:Animals; D015966:Gene Expression Regulation, Fungal; D056892:Mediator Complex; D046912:Multiprotein Complexes; D011499:Protein Processing, Post-Translational; D021122:Protein Subunits / Q000235:genetics / Q000378:metabolism; D012319:RNA Polymerase II / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
C058337:GAL11 protein, S cerevisiae; D056892:Mediator Complex; D046912:Multiprotein Complexes; D021122:Protein Subunits; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators; D012319:RNA Polymerase II