title: Taurolidine lock: the key to prevention of recurrent catheter-related bloodstream infections.
abstract: The literature shows that repeated courses of antibiotics and catheter removals in a subset of patients suffering from multiple catheter-related bloodstream infections (CRBSI), are unlikely to prevent recurrence. In acceding to preventative strategies, we report our application of the antimicrobial chemotherapeutic Taurolidine used as a daily flush solution in seven home TPN patients suffering from multiple episodes. A pretreatment infection rate of 10.8 infections per 1000 catheter days decreased to 0.8 after treatment.
authors.affiliation: Digestive Diseases Program, St. Michael's Hospital, University of Toronto, 30 Bond St., Toronto, Ont., Canada M5B 1W8. jurewitschb@smh.toronto.on.ca
authors.forename: Brian
authors.initials: B
authors.lastname: Jurewitsch
authors.forename: Khursheed N
authors.initials: KN
authors.lastname: Jeejeebhoy
mesh_terms: D000328:Adult; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D016470:Bacteremia / Q000517:prevention & control*; D002408:Catheters, Indwelling / Q000009:adverse effects / Q000382:microbiology*; D006801:Humans; D008875:Middle Aged; D016331:Parenteral Nutrition, Home / Q000009:adverse effects*; D013654:Taurine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D013829:Thiadiazines / Q000008:administration & dosage*
chemical_list: D000891:Anti-Infective Agents, Local; D013829:Thiadiazines; D013654:Taurine; C012566:taurolidine