Immuno-epidemiology of Ascaris lumbricoides infection in a high transmission community: antibody responses and their impact on current and future infection intensity.
The role of the humoral immune system in human infection with Ascaris lumbricoides remains unclear. This study documents an epidemiological investigation in a highly endemic community in Vietnam, whereby serum antibody levels were assessed before treatment and after a 6-month reinfection period. These data were examined by correlation with infection status using an age-structured approach in an attempt to help shed light on the role of the humoral immune response. The first part of this study characterized levels of all serum antibody isotypes from the community in response to antigens of both adult and larval A. lumbricoides. Data were assessed in terms of their relation to host age and infection intensity with the aim to provide a broadly detailed account of immune responses to the parasite. In the second part, antibody responses to both life-stages of A. lumbricoides in serum samples collected before anthelmintic chemotherapy were analysed in relation to intensity of re-infection with the parasite 6 months following treatment. The results suggest that antibody responses may not confer protection from current infection or re-infection with A. lumbricoides and may not serve as reliable indicators of future infection intensity. Our results thereby lend support to the theory that immunity to A. lumbricoides may not be based on the humoral immune system.
King
E-M
EM
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3FY, UK. Dr_evaking@hotmail.com
Kim
H T
HT
Dang
N T
NT
Michael
E
E
Drake
L
L
Needham
C
C
Haque
R
R
Bundy
D A P
DA
Webster
J P
JP
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood*; D000969:Antinematodal Agents / Q000627:therapeutic use; D001196:Ascariasis / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology*; D017164:Ascaris lumbricoides / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D011715:Pyrantel / Q000031:analogs & derivatives / Q000627:therapeutic use; D016036:Seroepidemiologic Studies; D014744:Vietnam / Q000453:epidemiology
D000909:Antibodies, Helminth; D000969:Antinematodal Agents; D004338:Drug Combinations; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; C029857:quantrel; D007073:Immunoglobulin E; D011715:Pyrantel