title: Duration of immunity against pertussis after natural infection or vaccination.
abstract: Despite decades of high vaccination coverage, pertussis has remained endemic and reemerged as a public health problem in many countries in the past 2 decades. Waning of vaccine-induced immunity has been cited as one of the reasons for the observed epidemiologic trend. A review of the published data on duration of immunity reveals estimates that infection-acquired immunity against pertussis disease wanes after 4-20 years and protective immunity after vaccination wanes after 4-12 years. Further research into the rate of waning of vaccine-acquired immunity will help determine the optimal timing and frequency of booster immunizations and their role in pertussis control.
authors.affiliation: Department of Epidemiology, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, USA. awendelboe@unc.edu
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Wendelboe
authors.forename: Annelies
authors.initials: A
authors.lastname: Van Rie
authors.forename: Stefania
authors.initials: S
authors.lastname: Salmaso
authors.forename: Janet A
authors.initials: JA
authors.lastname: Englund
mesh_terms: D003140:Communicable Disease Control; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology* / Q000502:physiology; D008297:Male; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000276:immunology*; D012680:Sensitivity and Specificity; D013997:Time Factors; D014611:Vaccination; D014917:Whooping Cough / Q000276:immunology* / Q000517:prevention & control*
chemical_list: D010567:Pertussis Vaccine