Common interleukin 10 polymorphism associated with decreased risk of tuberculosis.
Interleukin 10 (IL10) is a powerful TH2-cell cytokine that inhibits lymphocyte replication and secretion of inflammatory cytokines. The genetic associations of polymorphisms in IL10 with clinical manifestations of tuberculosis (TB) were examined in a large number of patients with clinical TB infection (n = 459) and normal controls (n = 871). One common promoter SNP (IL10 -592 A>C) was found to be significantly associated with decreased risk of TB manifestation. The frequency of the "C"-bearing genotype was higher in normal controls than in patients with clinical TB infection (P = 0.005, OR = 0.69). A summary of the genetic effect of IL10 -1082 A>G, the other nearby promoter SNP, in other ethnic groups is also presented.
Shin
Hyoung Doo
HD
Department of Genetic Epidemiology, SNP Genetics, Inc.11th Floor, MaeHun B/D, 13 Jongro 4 ga, Jongro-gu, Seoul 110-834, Korea.
Park
Byung Lae
BL
Kim
Young Hyo
YH
Cheong
Hyun Sub
HS
Lee
In Hee
IH
Park
Seung Kyu
SK
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D007723:Korea; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D014397:Tuberculosis, Pulmonary / Q000235:genetics*
D016753:Interleukin-10