[Interaction of viruses with cellular response to hypoxia].
Recent studies show that low oxygen tension levels in cell culture up-regulate the replication of human B19 parvovirus, Kaposi's sarcoma, and human immunodeficiency viruses as well as the expression of viral oncogenic proteins. The mechanisms of this regulation proceed with the major hypoxia-related factor, HIF-1 (hypoxia inducible factor-1). HIF-1 misregulation is implicated in the oncogenesis potential of some of these viruses.
Pillet
Sylvie
S
Laboratoire de bactériologie-virologie, Hôpital Nord et Faculté de médecine Jacques Lisfranc, CHU de Saint-Etienne, 27, boulevard Pasteur, 42100 Saint-Etienne, France. sylvie.pillet@univ-st-etienne.fr
Le Guyader
Nathalie
N
D000818:Animals; D015687:Cell Hypoxia; D015967:Gene Expression Regulation, Viral / Q000502:physiology; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000502:physiology; D009856:Oncogene Proteins, Viral / Q000502:physiology; D018406:Virus Physiological Phenomena
D051793:Hypoxia-Inducible Factor 1; D009856:Oncogene Proteins, Viral