title: Multiple autoantigen mimotopes of infectious agents induce autoimmune arthritis and uveitis in lewis rats.
abstract: We found multimolecular antigenic mimicry of arthritogenic autoantigens and peptides from several other "self" or foreign antigens sharing amino acid sequence homologies. Many of these new mimotopes induced arthritis and/or uveitis upon immunization in Lewis rats, indicating a role for multiple antigens in the initiation of a certain autoimmune disease.
authors.affiliation: Section of Immunobiology, Dept. of Ophthalmology, Ludwig-Maximilians-University, Mathildenstr. 8, 80336 Munich, Germany. Gerhild.Wildner@med.uni-muenchen.de
authors.forename: Gerhild
authors.initials: G
authors.lastname: Wildner
authors.forename: Maria
authors.initials: M
authors.lastname: Diedrichs-Moehring
mesh_terms: D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D001169:Arthritis, Experimental / Q000209:etiology / Q000276:immunology*; D001324:Autoantigens; D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology; D003429:Cross Reactions / Q000276:immunology; D007114:Immunization; D018716:Molecular Mimicry / Q000276:immunology*; D010455:Peptides / Q000008:administration & dosage / Q000276:immunology*; D051381:Rats; D011917:Rats, Inbred Lew; D017386:Sequence Homology, Amino Acid; D014605:Uveitis / Q000209:etiology / Q000276:immunology*
chemical_list: D000941:Antigens; D001324:Autoantigens; D010455:Peptides