Oxazine 170 induces DNA:RNA:DNA triplex formation.
The oxazine dye (Oxazine 170) was found to induce formation of a hybrid triplex structure, poly rA:(poly dT)(2), under solution conditions in which the triplex would not otherwise form. Formation of the hybrid triplex is driven by the structural selective binding of oxazine 170 to poly rA:(poly dT)(2). Oxazine 170 serves as a lead compound for the design of new compounds that can modulate triplex formation.
Song
Guangtao
G
Key Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin 130022, China.
Xing
Feifei
F
Qu
Xiaogang
X
Chaires
Jonathan B
JB
Ren
Jinsong
J
D003956:Dialysis; D010078:Oxazines / Q000737:chemistry*; D011061:Poly A / Q000138:chemical synthesis*; D011071:Poly T / Q000138:chemical synthesis*
C500837:5,9-bis(diethylamino)-10-methylbenzo(a)phenoxazonium; D010078:Oxazines; D011061:Poly A; D011071:Poly T; C008950:poly A-T