Tuning the size of macrocyclic cavities in trianglimine macrocycles.
The synthesis of aromatic dicarboxaldehydes is described along with their reactivity in the [3 + 3] cyclocondensation reaction with (1R,2R)-diaminocyclohexane to give trianglimine macrocycles. In particular, the scope and limitation of the reaction with regard to complete control of the cavity size of the macrocycles is discussed producing a total of 11 macrocycles with different cavity sizes ranging from 9 to 23 angstroms.
Kuhnert
Nikolai
N
Supramolecular and Biomolecular Chemistry Laboratory, Chemistry (C-4), School of Biomedical and Molecular Sciences, The University of Surrey, Guildford, UKGU2 7XH. n.kuhnert@surrey.ac.uk
Burzlaff
Nicolai
N
Patel
Chirag
C
Lopez-Periago
Ana
A
D000447:Aldehydes / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
D000447:Aldehydes