Kinetic analysis of hydrolytic reaction of homo- and heterochiral adenylyl(3'-5')adenosine isomers: breaking homochirality reduces hydrolytic stability of RNA.
The hydrolytic stability of the diastereomeric isomers of ApA was compared and the results show that heterochiral ApAs are more rapidly hydrolyzed than homochiral ApAs at low temperatures, suggesting that hydrolytic selection in cold environments in conjunction with selective polymerization may have been effective in enriching the homochirality of RNA.
Urata
Hidehito
H
Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka, 569-1094, Japan. urata@gly.oups.ac.jp
Sasaki
Rie
R
Morita
Hiroyo
H
Kusumoto
Marina
M
Ogawa
Yoko
Y
Mitsuda
Kozue
K
Akagi
Masao
M
D015226:Dinucleoside Phosphates / Q000737:chemistry*; D006868:Hydrolysis; D007536:Isomerism; D007700:Kinetics; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry*; D013237:Stereoisomerism
D015226:Dinucleoside Phosphates; C006412:adenylyl-(3'-5')-adenosine; D012313:RNA