title: Near confluent laser photocoagulation for the treatment of threshold retinopathy of prematurity.
abstract: OBJECTIVE
  To evaluate the effect of a near confluent pattern of indirect laser photocoagulation in reducing the rate of progression and re-treatment of threshold retinopathy of prematurity.
  
  
  METHODS
  This study examined a noncomparative interventional case series. We performed a retrospective review of the medical records of patients who underwent peripheral laser ablation by 1 surgeon for threshold retinopathy of prematurity from 1997 to 2002. A total of 58 eyes from 31 patients were treated, and 44 eyes of 23 patients were included in the study. Ten eyes of 5 infants had zone 1 disease, and 34 eyes of 18 infants had zone 2 disease. Laser spots were placed in a near confluent pattern in the peripheral avascular retina between the ridge of extraretinal proliferation and the ora serrata. The mean +/- SD number of laser spots was 2534 +/- 455 for zone 1 (range, 2100-3378) and 1850 +/- 487 for zone 2 (range, 1030-2689).
  
  
  RESULTS
  In 7 eyes of 4 infants with zone 1 disease, the retinopathy regressed and did not require any further treatment. Three eyes of 2 infants, however, progressed after laser treatment and required vitrectomy surgery. Progression was defined as the development of stage 4 or 5 disease. None of the patients with zone 2 disease had progression of retinopathy, and none of them needed more than 1 treatment. Patients tolerated the procedure well, and there were no complications at the time of the procedure or at follow-up visits.
  
  
  CONCLUSIONS
  A near confluent pattern of laser photocoagulation may reduce the rate of progression of threshold retinopathy of prematurity in zone 2 (0%). The near confluent pattern of treatment may also reduce the re-treatment rate of the disease (0%). Larger studies are needed to confirm our findings.
authors.affiliation: Kresge Eye Institute, Wayne State University School of Medicine, 4717 St. Antoine, Detroit, MI 48201, USA.
authors.forename: Kourous A
authors.initials: KA
authors.lastname: Rezai
authors.forename: Dean
authors.initials: D
authors.lastname: Eliott
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Ferrone
authors.forename: Rubin W
authors.initials: RW
authors.lastname: Kim
mesh_terms: D001724:Birth Weight; D018450:Disease Progression; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D017075:Laser Coagulation / Q000379:methods*; D008297:Male; D012178:Retinopathy of Prematurity / Q000503:physiopathology / Q000601:surgery*; D012189:Retrospective Studies