title: Floating-Harbor syndrome complicated by tethered cord: a new association and potential contribution from growth hormone therapy.
abstract: Floating-Harbor syndrome is a rare syndrome with short stature, severely delayed bone age, typical facies and delay in expressive speech. Structural malformations are uncommon, and tethered cord or other forms of spinal dysraphism have not previously been reported. We report on a case of Floating-Harbor syndrome, complicated by tethered cord and discuss the possibility that growth hormone therapy may contribute to the development of symptoms of this malformation.
authors.affiliation: Department of Paediatrics and Child Health, Wellington School of Medicine and Health Sciences, Wellington South, New Zealand. esko@wnmeds.ac.nz
authors.forename: Esko
authors.initials: E
authors.lastname: Wiltshire
authors.forename: Agadha
authors.initials: A
authors.lastname: Wickremesekera
authors.forename: Joanne
authors.initials: J
authors.lastname: Dixon
mesh_terms: D000015:Abnormalities, Multiple / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D001848:Bone Diseases, Developmental / Q000473:pathology*; D002648:Child; D005145:Face / Q000002:abnormalities*; D005260:Female; D006130:Growth Disorders / Q000473:pathology*; D019382:Human Growth Hormone / Q000627:therapeutic use; D006801:Humans; D007621:Karyotyping; D007805:Language Development Disorders / Q000473:pathology; D016135:Spinal Dysraphism / Q000473:pathology*; D013577:Syndrome; D016896:Treatment Outcome
chemical_list: D019382:Human Growth Hormone