title: Transient cochlear ischemia and its effects on the stria vascularis.
abstract: The effects of transient cochlear ischemia on the stria vascularis were studied. Fifteen minutes of ischemia decreased the endocochlear potential by up to 17.5 mV on day 1; it returned to normal on day 7. Immunostaining for Na+,K+-ATPase, a marker for the Na+/K+-pump, and for connexin 26, a marker for gap junctions, was inhibited on days 1 and 4, and returned to normal on day 7. Electron microscopy showed expansion of the intercellular space with abundant vacuolar formation in the stria vascularis. These morphological changes disappeared completely by day 7. The results indicate that transient ischemia causes a reversible functional disorder of the stria vascularis with fine structural changes, which may be owing to dysfunction of Na+/K+-pump or gap junctions.
authors.affiliation: Department of Otolaryngology, Ehime University School of Medicine, Ehime, Japan.
authors.forename: Isao
authors.initials: I
authors.lastname: Morizane
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Hakuba
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Shinomori
authors.forename: Kensuke
authors.initials: K
authors.lastname: Fujita
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yoshida
authors.forename: Masachika
authors.initials: M
authors.lastname: Shudou
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Gyo
mesh_terms: D000818:Animals; D015834:Cochlear Diseases / Q000378:metabolism / Q000503:physiopathology*; D003055:Cochlear Microphonic Potentials / Q000502:physiology*; D000072259:Connexin 26; D017630:Connexins / Q000378:metabolism; D005849:Gerbillinae; D007150:Immunohistochemistry / Q000379:methods; D002546:Ischemic Attack, Transient / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D046529:Microscopy, Electron, Transmission / Q000379:methods; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013316:Stria Vascularis / Q000473:pathology / Q000502:physiology* / Q000648:ultrastructure; D013997:Time Factors
chemical_list: D017630:Connexins; D000072259:Connexin 26; D000254:Sodium-Potassium-Exchanging ATPase