Role of cytokines in experimental and clinical uveitis.
Uveitis is a major cause of visual impairment. Experimental autoimmune uveitis mimics the clinical conditions of posterior uveitis in many ways. T-cells (particularly CD4+ helper-T-cells) have been shown to play an important role in pathogenesis of experimental and clinical uveitis. Based on the pattern of cytokine they secrete, CD4+ helper cells have been divided into Th1 and Th2 subsets. Various Th1 and Th2 cytokines appear to be involved in the pathogenesis and/or recovery from uveitis. This article discusses in detail the uveitopathogenic and therapeutic potential of Th1 and Th2 cytokines in experimental and clinical uveitis.
Singh
V K
VK
Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. vksingh@sgpgi.ac.in
Rai
G
G
Agarwal
S S
SS
D000818:Animals; D002986:Clinical Trials as Topic; D016207:Cytokines / Q000627:therapeutic use*; D004195:Disease Models, Animal; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D051381:Rats; D014605:Uveitis / Q000188:drug therapy*
D016207:Cytokines; D007166:Immunosuppressive Agents