title: Thrombophilia and venous thromboembolism. International consensus statement. Guidelines according to scientific evidence.
abstract: Thrombophilia is the term now used to describe predisposition to increased risk of venous and occasionally arterial thromboembolism due to hematological abnormalities. It can be a multifactorial disorder where congenital defects of anticoagulant or procoagulant factors may be combined with acquired hematological abnormalities. It should be considered in patients with a documented unexplained thrombotic episode or a positive family history. The aim of this document is to provide guidelines for investigation and management of patients with thrombophilia in the presence or absence of venous thromboembolism (VTE).
authors.forename: A N
authors.initials: AN
authors.lastname: Nicolaides
authors.forename: H K
authors.initials: HK
authors.lastname: Breddin
authors.forename: P
authors.initials: P
authors.lastname: Carpenter
authors.forename: S
authors.initials: S
authors.lastname: Coccheri
authors.forename: J
authors.initials: J
authors.lastname: Conard
authors.forename: V
authors.initials: V
authors.lastname: De Stefano
authors.forename: N
authors.initials: N
authors.lastname: Elkoofy
authors.forename: G
authors.initials: G
authors.lastname: Gerotziafas
authors.forename: S
authors.initials: S
authors.lastname: Guermazi
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authors.initials: S
authors.lastname: Haas
authors.forename: R
authors.initials: R
authors.lastname: Hull
authors.forename: E
authors.initials: E
authors.lastname: kalodiki
authors.forename: V
authors.initials: V
authors.lastname: Kristof
authors.forename: J J
authors.initials: JJ
authors.lastname: Michiels
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authors.lastname: Myers
authors.forename: G
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authors.lastname: Pineo
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authors.initials: P
authors.lastname: Prandoni
authors.forename: G
authors.initials: G
authors.lastname: Romeo
authors.forename: M M
authors.initials: MM
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authors.initials: S
authors.lastname: Simonian
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authors.initials: S
authors.lastname: Xenophonthos
mesh_terms: D020016:Activated Protein C Resistance / Q000503:physiopathology; D016736:Antiphospholipid Syndrome / Q000453:epidemiology; D005060:Europe / Q000453:epidemiology; D005165:Factor V / Q000235:genetics; D005169:Factor VIII / Q000032:analysis; D020249:Hormone Replacement Therapy / Q000009:adverse effects; D006801:Humans; D020138:Hyperhomocysteinemia / Q000453:epidemiology; D009154:Mutation; D017293:Protein S / Q000032:analysis; D012008:Recurrence; D019851:Thrombophilia / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D020246:Venous Thrombosis / Q000209:etiology* / Q000503:physiopathology
chemical_list: D017293:Protein S; C095381:factor V Leiden; D005165:Factor V; D005169:Factor VIII