Chemotherapy of leishmaniasis part II: synthesis and bioevaluation of substituted arylketene dithioacetals as antileishmanial agents.
Some novel aryl substituted ketene dithioacetals have been synthesized using novel synthetic methods. The compounds were screened against Leishmania donovani in hamsters for their activity profile. Some of the compounds inhibited 50-65% parasite growth at 50 mg kg(-1) x 5 days.
Pandey
Susmita
S
Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India.
Suryawanshi
S N
SN
Gupta
Suman
S
Srivastava
V M L
VM
D000080:Acetals / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006224:Cricetinae; D005030:Ethylenes / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D007659:Ketones / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D007891:Leishmania / Q000187:drug effects*; D007896:Leishmaniasis / Q000188:drug therapy*; D021261:Parasitic Sensitivity Tests
D000080:Acetals; D000981:Antiprotozoal Agents; D005030:Ethylenes; D007659:Ketones; C008223:ketene