The effect of packaging materials on the stability of sunscreen emulsions.
The purpose of this research was to study the stability of a emulsion containing UVA, UVB and infrared sunscreens after storage in different types of packaging materials (glass and plastic flasks; plastic and metallic tubes). The samples, emulsions containing benzophenone-3 (B-3), octyl methoxycinnamate (OM) and Phycocorail, were stored at 10, 25, 35 and 45 degrees C and representative samples were analyzed after 2, 7, 30, 60 and 90 days period. The stability studies were conducted by analyzing samples at pre-determined intervals by high performance liquid chromatography (HPLC) along with periodic rheological measurements.
Santoro
Maria Inês R M
MI
Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, Caixa Postal 66083, CEP 05315-970 São Paulo, SP, Brazil. ines@usp.br
Da Costa E Oliveira
Daniella Almança Gonçalves
DA
Kedor-Hackmann
Erika R M
ER
Singh
Anil K
AK
D002851:Chromatography, High Pressure Liquid; D004349:Drug Packaging; D004355:Drug Stability; D004655:Emulsions; D007202:Indicators and Reagents; D012015:Reference Standards; D015203:Reproducibility of Results; D012212:Rheology; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet; D013473:Sunscreening Agents / Q000737:chemistry*
D004655:Emulsions; D007202:Indicators and Reagents; D012997:Solvents; D013473:Sunscreening Agents