Polymorphisms in RAI and in genes of nucleotide and base excision repair are not associated with risk of testicular cancer.
Testicular cancer has been suggested to be primed in utero and there is familiar occurrence, particularly brothers and sons of men with testicular cancer have increased risk. Although no specific causative genotoxic agents have been identified, variations in DNA repair capacity could be associated with the risk of testicular cancer. A case-control study of 184 testicular cancer cases and 194 population-based controls living in the Copenhagen Greater Area in Denmark was performed. We found that neither polymorphisms in several DNA repair genes nor alleles of several polymorphisms in the chromosomal of region 19q13.2-3, encompassing the genes ASE, ERCC1, RAI and XPD, were associated with risk of testicular cancer in Danish patients. This is in contrast to other cancers, where we reported strong associations between polymorphisms in ERCC1, ASE and RAI and occurrence of basal cell carcinoma, breast cancer and lung. To our knowledge this is the first study of DNA repair gene polymorphisms and risk of testicular cancer.
Laska
Magdalena J
MJ
Institute of Human Genetics, University of Aarhus, Bartholin Building, DK-8000 Aarhus C, Denmark.
Nexø
Bjørn A
BA
Vistisen
Kirsten
K
Poulsen
Henrik Enghusen
HE
Loft
Steffen
S
Vogel
Ulla
U
D016022:Case-Control Studies; D004260:DNA Repair / Q000235:genetics*; D003718:Denmark; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008297:Male; D009711:Nucleotides / Q000235:genetics / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012097:Repressor Proteins; D013736:Testicular Neoplasms / Q000235:genetics*
D047908:Intracellular Signaling Peptides and Proteins; D009711:Nucleotides; C119612:PPP1R13L protein, human; D012097:Repressor Proteins