Nephrotoxicity associated with exposure to plant toxins, with particular reference to Africa.
Acute renal failure is a frequent cause of morbidity and mortality in the hospitalized population worldwide. In Africa, apart from hemodynamic causes and infections, herbal remedies contribute to both morbidity and mortality, although these causes often go unrecognized. This paper reviews reports of herbal remedies that have been shown to result in nephrotoxicity. The indications for use of the remedies, signs and symptoms in poisoned patients, and the methods used to detect toxic compounds in plant specimens or in biological fluids are covered.
Steenkamp
Vanessa
V
Department of Pharmacology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa. vsteen@med.up.ac.za
Stewart
Michael J
MJ
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000349:Africa; D029001:Herbal Medicine; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D009145:Mushroom Poisoning / Q000150:complications; D010939:Plant Poisoning / Q000150:complications*