[Effects of cytokines on the immunogenic properties of hepatitis A vaccine].
Cytokines were found, in experiments with guinea pigs, to have a stimulating action on the immunogenic potency of hepatitis A vaccine (Hep-A-in-Vac). The most pronounced effects were produced by rhIL-1b, rhTNF-alpha, thymosin-a1, the "neothym" hybrid protein and immunophan. Injections of cytokines as of adjuvants stimulated the formation of antibodies titers that exceeded 2-10-fold those observed in control animals immunized by Hep-A-in-Vac alone. Immunization of guinea pigs made alongside with injections of the above cytokines ensured a 100% seroconversion in animals after the administration of drugs was completed. The number of seropositive animals in the control group was 75-89%.
Avdeeva
Zh I
ZhI
Akol'zina
S E
SE
Alpatova
N A
NA
Medunitsyn
N V
NV
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D006168:Guinea Pigs; D022362:Hepatitis A Vaccines / Q000008:administration & dosage / Q000276:immunology*; D030041:Hepatitis A virus / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000096:biosynthesis* / Q000097:blood; D007279:Injections, Subcutaneous; D007375:Interleukin-1 / Q000008:administration & dosage; D011994:Recombinant Proteins / Q000494:pharmacology; D000077596:Thymalfasin; D013947:Thymosin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage; D014611:Vaccination
D000276:Adjuvants, Immunologic; D022362:Hepatitis A Vaccines; D006508:Hepatitis Antibodies; D007375:Interleukin-1; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D013947:Thymosin; D000077596:Thymalfasin