title: The use of animal models to guide rational vaccine design.
abstract: Although there are several varieties of animal models of tuberculosis, the mouse and the guinea pig are by far the most validated and useful. These provide information about vaccine-induced protection, immunogenicity, toxicity, and immunopathological effects. There is still much to be learned, however, in terms of rational vaccine design, especially in the context of therapeutic or anti-latent vaccine formulations and animal models of these situations.
authors.affiliation: Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA. ian.orme@colostate.edu
authors.forename: Ian M
authors.initials: IM
authors.lastname: Orme
mesh_terms: D000818:Animals; D001500:BCG Vaccine; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006168:Guinea Pigs; D051379:Mice; D023421:Models, Animal; D009169:Mycobacterium tuberculosis / Q000276:immunology; D014376:Tuberculosis / Q000517:prevention & control*; D032581:Tuberculosis Vaccines
chemical_list: D001500:BCG Vaccine; D032581:Tuberculosis Vaccines