title: Percutaneous transcatheter closure of atrial septal defects: initial single-centre experience and follow-up results. Initial experience with three-dimensional echocardiography.
abstract: OBJECTIVE
  Registry to report our single-centre experience in closing defects of the atrial septum.
  
  
  METHODS
  Between 1996 and 2001, transcatheter device closure of significant atrial septal defects was performed in 32 adults (mean age 45.1 years, range from 15 to 76 years), using different device types. Six patients had a patent foramen ovale (PFO) and 26 patients had a secundum atrial septal defect (ASD II). Defects were selected by means of two-dimensional transoesophageal echocardiography (2D TOE). For 12 defects additional three-dimensional transoesophageal echocardiography (3D TOE) was performed.
  
  
  RESULTS
  Mean balloon-stretched diameter was 19.3 mm (range from 11 to 24 mm). A device was successfully placed in all PFO patients (100%) without complications at follow-up. Successful immediate device placement occurred in 24 out of 26 ASD patients. Two immediate placement failures, 1 device embolisation and 1 device non-fixation, occurred and required urgent surgery. There was 1 patient with pericardial effusion after the intervention, requiring pericardiocentesis. Three late placement failures occurred: 2 device embolisations and 1 device dislocation. Clinical success after 3 to 6 months follow-up, defined as the absence of shunt or small shunt, was achieved in all 6 PFO patients and in 21 out of 23 ASD patients (1 device embolisation, requiring surgery, occurred before follow-up was completed). Two patients with significant shunt, 1 late device dislocation and 1 late device embolisation, underwent elective surgery. For patient selection, 3D TOE proved useful in the evaluation of large and/or complex defects.
  
  
  CONCLUSIONS
  Transcatheter device closure of carefully selected atrial septal defects is an alternative to surgery. Although the results are promising, surgical back-up is often needed.
authors.affiliation: Heart Lung Center Utrecht, Department of Cardiology, Antonius Hospital Nieuwegein, Nieuwegein, The Netherlands. sergederidder@hotmail.com
authors.forename: Serge
authors.initials: S
authors.lastname: De Ridder
authors.forename: Maarten-Jan
authors.initials: MJ
authors.lastname: Suttorp
authors.forename: Sjef M P G
authors.initials: SM
authors.lastname: Ernst
authors.forename: Jacob A
authors.initials: JA
authors.lastname: Six
authors.forename: Herman F J
authors.initials: HF
authors.lastname: Mannaerts
authors.forename: Otto
authors.initials: O
authors.lastname: Kamp
authors.forename: Thijs H W M
authors.initials: TH
authors.lastname: Plokker
authors.forename: Wybren
authors.initials: W
authors.lastname: Jaarsma
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D006328:Cardiac Catheterization; D019560:Echocardiography, Three-Dimensional; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000000981:diagnostic imaging / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019736:Prostheses and Implants