Effect of media composition and in vitro activity of posaconazole, caspofungin and voriconazole against zygomycetes.
OBJECTIVE
The effect of different media and composition on the in vitro activity of posaconazole, caspofungin and voriconazole against 59 zygomycetes species was determined.


METHODS
The media tested were RPMI 1640 medium with and without 2% glucose, antibiotic medium 3 (AM3) with and without 2% glucose, and high resolution (HR) medium.


RESULTS
Posaconazole was significantly more active than caspofungin and voriconazole, both in RPMI 1640 medium with 2% glucose and in HR medium. Adding glucose improved the determination of end points, but had only minor influence on the MICs. MICs evaluated in AM3 were lower than in RPMI 1640 medium or HR medium.


CONCLUSIONS
The in vivo effect of posaconazole in zygomycosis needs further evaluation.
Gil-Lamaignere
Cristina
C
Department of Paediatrics III, Paediatric Pulmonology and Infectious Diseases, University of Heidelberg, Im Neuenheimer Feld 153, D-69120 Heidelberg, Germany.
Hess
Regina
R
Salvenmoser
Stefanie
S
Heyn
Kathrin
K
Kappe
Reinhard
R
Müller
Frank-Michael C
FM
D020095:Absidia / Q000187:drug effects / Q000254:growth & development; D000935:Antifungal Agents / Q000494:pharmacology*; D000077336:Caspofungin; D003470:Culture Media; D020093:Cunninghamella / Q000187:drug effects / Q000254:growth & development; D054714:Echinocandins; D055666:Lipopeptides; D008826:Microbial Sensitivity Tests; D009089:Mucor / Q000187:drug effects / Q000254:growth & development; D009090:Mucorales / Q000187:drug effects* / Q000254:growth & development; D010456:Peptides, Cyclic / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D012233:Rhizopus / Q000187:drug effects / Q000254:growth & development; D014230:Triazoles / Q000494:pharmacology*; D065819:Voriconazole
D000935:Antifungal Agents; D003470:Culture Media; D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; D011743:Pyrimidines; D014230:Triazoles; C101425:posaconazole; D000077336:Caspofungin; D065819:Voriconazole