title: Chemotherapy of leishmaniasis part II: synthesis and bioevaluation of substituted arylketene dithioacetals as antileishmanial agents.
abstract: Some novel aryl substituted ketene dithioacetals have been synthesized using novel synthetic methods. The compounds were screened against Leishmania donovani in hamsters for their activity profile. Some of the compounds inhibited 50-65% parasite growth at 50 mg kg(-1) x 5 days.
authors.affiliation: Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India.
authors.forename: Susmita
authors.initials: S
authors.lastname: Pandey
authors.forename: S N
authors.initials: SN
authors.lastname: Suryawanshi
authors.forename: Suman
authors.initials: S
authors.lastname: Gupta
authors.forename: V M L
authors.initials: VM
authors.lastname: Srivastava
mesh_terms: D000080:Acetals / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006224:Cricetinae; D005030:Ethylenes / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D007659:Ketones / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D007891:Leishmania / Q000187:drug effects*; D007896:Leishmaniasis / Q000188:drug therapy*; D021261:Parasitic Sensitivity Tests
chemical_list: D000080:Acetals; D000981:Antiprotozoal Agents; D005030:Ethylenes; D007659:Ketones; C008223:ketene