Coexistence of movement disorders and epilepsia partialis continua as the initial signs in probable Creutzfeldt-Jakob disease.
Movement disorders and epilepsy rarely occur in the early stage of Creutzfeldt-Jakob disease (CJD) but have not been reported concurrently. We report on a 47-year-old patient with probable CJD who presented with generalized chorea and focal dystonia with myoclonic jerks on the right hand. Myoclonic jerks progressed to epilepsia partialis continua within 5 days of admission to the hospital. The diagnosis of our patient was compatible with probable CJD on the basis of clinical course, electroencephalogram, and diffusion-weighted magnetic resonance imaging findings, and presence of 14-3-3 protein in cerebrospinal fluid. To our knowledge, this is the first report of a case developing both movement disorders and epilepsia partialis continua in the early stage of the disease.
Donmez
Berril
B
Department of Neurology, Medical School of Dokuz Eylül University; Izmir, Turkey.
Cakmur
Raif
R
Men
Süleyman
S
Oztura
Ibrahim
I
Kitis
Arzu
A
D001479:Basal Ganglia / Q000473:pathology; D002421:Caudate Nucleus / Q000503:physiopathology; D007562:Creutzfeldt-Jakob Syndrome / Q000453:epidemiology* / Q000473:pathology; D003937:Diagnosis, Differential; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D005260:Female; D006179:Gyrus Cinguli / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009069:Movement Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D011699:Putamen / Q000503:physiopathology; D012720:Severity of Illness Index; D013788:Thalamus / Q000503:physiopathology