title: Treatment of advanced malignant eccrine poroma with locoregional chemotherapy.
abstract: Malignant eccrine poroma is a rare disease with approximately 200 cases reported in the literature. Regional cutaneous and systemic metastases are rarely observed and their management has been generally unsuccessful. We report on a case in which topical 5-fluorouracil application and intra-arterial chemotherapy with docetaxel resulted in a histologically confirmed complete response of multiple regional skin metastases for more than 2 years. Despite intravenous administration of docetaxel, slow progression of systemic disease was observed.
authors.affiliation: Department of Surgical Oncology, University Hospital, Medical School of Crete, Herakleion, Greece. debree@edu.uoc.gr
authors.forename: E
authors.initials: E
authors.lastname: de Bree
authors.forename: E
authors.initials: E
authors.lastname: Volalakis
authors.forename: D
authors.initials: D
authors.lastname: Tsetis
authors.forename: Y
authors.initials: Y
authors.lastname: Varthalitis
authors.forename: J
authors.initials: J
authors.lastname: Panagiotidis
authors.forename: J
authors.initials: J
authors.lastname: Romanos
authors.forename: D D
authors.initials: DD
authors.lastname: Tsiftsis
mesh_terms: D018250:Acrospiroma / Q000188:drug therapy* / Q000473:pathology; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018450:Disease Progression; D000077143:Docetaxel; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007866:Leg; D008297:Male; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary; D013544:Sweat Gland Neoplasms / Q000188:drug therapy* / Q000473:pathology; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D005472:Fluorouracil