Brain perfusion differences between Parkinson's disease and multiple system atrophy with predominant parkinsonian features.
BACKGROUND
The patterns of regional cerebral blood flow in Parkinson's disease and multiple system atrophy remain inconsistent.


OBJECTIVE
To compare brain perfusion images of 123I-IMP SPECT between Parkinson's disease, multiple system atrophy with predominant parkinsonian features (MSA-P) and controls.


METHODS
Eighty-two patients with Parkinson's disease, 10 patients with MSA-P and 14 controls were studied. We performed 3D-SSP and volume of interest analysis using 123I-IMP scintigraphy.


RESULTS
Occipital perfusion of MSA-P increased compared to that of Parkinson's disease and perfusion in the cerebellum and primary sensorimotor cortex of Parkinson's disease increased compared to that of MSA-P. Perfusion in the putamen of MSA-P decreased compared to that of Parkinson's disease.


CONCLUSIONS
Our study demonstrated perfusion differences in 123I-IMP SPECT between the two diseases.
Matsui
Hideaki
H
Department of Neurology, Sumitomo Hospital, 5-3-20 Nakanoshima, Osaka 530-0005, Japan. matsui-hideaki@sumitomo-hp.or.jp
Udaka
Fukashi
F
Miyoshi
Takafumi
T
Hara
Narihiro
N
Tamura
Akiko
A
Oda
Masaya
M
Kubori
Tamotsu
T
Nishinaka
Kazuto
K
Kameyama
Masakuni
M
D000368:Aged; D002560:Cerebrovascular Circulation; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000000981:diagnostic imaging* / Q000503:physiopathology; D010300:Parkinson Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals