Oxidative imbalance and cathepsin D changes as peripheral blood biomarkers of Alzheimer disease: a pilot study.
Markers of oxidative stress in peripheral blood from patients with Alzheimer disease (AD) were analyzed. Thirty-three AD patients were recruited. Plasma antioxidant power (AOP), plasma Cystatin C as well as Cathepsin D in PBL were evaluated. We found that the AOP levels were significantly decreased in AD patients if compared to healthy donors, while the plasma level of Cystatin C was significantly higher. Importantly, a significantly decreased expression of Cathepsin D in PBL was also observed. These results suggest that oxidative imbalance in the peripheral blood of AD patients could mirror oxidative changes previously described in the central nervous system.
Straface
Elisabetta
E
Department of Drug Research and Evaluation, Section of Cell Aging and Degeneration, Istituto Superiore di Sanità, Rome, Italy.
Matarrese
Paola
P
Gambardella
Lucrezia
L
Vona
Rosa
R
Sgadari
Antonio
A
Silveri
Maria Caterina
MC
Malorni
Walter
W
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood*; D016564:Amyloid beta-Protein Precursor / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D001792:Blood Platelets / Q000378:metabolism; D002402:Cathepsin D / Q000097:blood*; D055316:Cystatin C; D015891:Cystatins / Q000097:blood; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress; D010865:Pilot Projects
D016564:Amyloid beta-Protein Precursor; D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D002402:Cathepsin D