Irreversible inhibition of metallo-beta-lactamase (IMP-1) by 3-(3-mercaptopropionylsulfanyl)propionic acid pentafluorophenyl ester.
Kurosaki
Hiromasa
H
Department of Structure-Function Physical Chemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe-honmachi 5-1, Kumamoto 862-0973, Japan.
Yamaguchi
Yoshihiro
Y
Higashi
Toshihiro
T
Soga
Kimitaka
K
Matsueda
Satoshi
S
Yumoto
Haruka
H
Misumi
Shogo
S
Yamagata
Yuriko
Y
Arakawa
Yoshichika
Y
Goto
Masafumi
M
D001665:Binding Sites; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D004952:Esters / Q000737:chemistry / Q000494:pharmacology*; D006868:Hydrolysis; D008958:Models, Molecular; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000737:chemistry / Q000494:pharmacology*; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000737:chemistry; D005464:Fluorobenzenes; D005466:Fluorocarbons
D004791:Enzyme Inhibitors; D004952:Esters; D013438:Sulfhydryl Compounds; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases; C513689:3-(3-mercaptopropionylsulfanyl)propionic acid pentafluorophenyl ester; D005464:Fluorobenzenes; D005466:Fluorocarbons; C409201:beta-lactamase IMP-1