Studies on the development of taste-masked suspension of chloroquine.
A non-bitter chloroquine suspension formulation for pediatric use was prepared in the form of an ion-pair of chloroquine with pamoic acid. Various parameters involved in the formulation of a stable and palatable suspension have been optimized. The suspension was characterized for particle size analysis, viscosity, physical and chemical stability and taste. Release of chloroquine from the ion-pair conducted as dissolution rate studies in simulated gastric media showed near to 100% release instantaneously. In-vivo bioavailability study conducted in albino rats indicated comparable bioavailability of chloroquine from the suspension with that of chloroquine phosphate syrup taken as standard. Stability study conducted over a period of 3 months showed the intactness of the ion-pair and the tasteless behavior of the suspension throughout the period of storage.
Chandibhamar
Vaishali
V
Pharmacy Department, Faculty of Technology and Engineering, MS University of Baroda, Kalabhavan, Vadodara, India.
Yadav
M R
MR
Murthy
R S R
RS
D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage* / Q000009:adverse effects; D002738:Chloroquine / Q000008:administration & dosage* / Q000009:adverse effects; D004355:Drug Stability; D005260:Female; D008297:Male; D051381:Rats; D013056:Spectrophotometry, Ultraviolet; D013535:Suspensions; D013649:Taste / Q000187:drug effects*
D000962:Antimalarials; D013535:Suspensions; D002738:Chloroquine