title: Influence of Ca2+ oscillatory influx on membrane Ca2+-ATPase activity: a kinetic model.
abstract: A kinetic model for the membrane Ca2+-ATPase is considered. The catalytic cycle in the model is extended by enzyme auto-inhibition and by oscillatory calcium influx. It is shown that the conductive enzyme activity can be registered as damped or sustained Ca2+ pulses similar to observed experimentally. It is shown that frequency variations in Ca2+ oscillatory influx induce changes of pulsating enzyme activity. Encoding is observed for the signal frequency into a number of fixed levels of sustained pulses in the enzyme activity. At certain calcium signal frequencies, the calculated Ca2+-ATPase conductivity demonstrates chaotic multi-level pulses, similar to those observed experimentally.
authors.affiliation: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia. goldstein@iteb.ru
authors.forename: B N
authors.initials: BN
authors.lastname: Goldstein
authors.forename: A A
authors.initials: AA
authors.lastname: Mayevsky
authors.forename: D T
authors.initials: DT
authors.lastname: Zakrjevskaya
mesh_terms: D000818:Animals; D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008954:Models, Biological
chemical_list: D000252:Calcium-Transporting ATPases; D002118:Calcium