title: Molecular evolution and subfunctionalization of Nkx2.1 in the rainbow trout.
abstract: Because specification of duplicated genes is considered to be a major driving force for diversity and evolution, it is important to understand the function of the duplicated genes. In mammals, Nkx2.1 is essential for the differentiation of thyroid follicular cells and for the transcription of thyroid-specific genes. We have cloned four distinct Nkx2.1 cDNAs from the rainbow trout, Oncorhynchus mykiss. In the present article, we will characterize the trout Nkx2.1 mRNAs and show their tissue distribution, their transcriptional activities, and their expression during early development.
authors.affiliation: Department of Biology, Faculty of Science, Shizuoka University, Japan. sbmsuzu@ipc.shizuoka.ac.jp
authors.forename: Masakazu
authors.initials: M
authors.lastname: Suzuki
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Hidaka
authors.forename: Youji
authors.initials: Y
authors.lastname: Uemae
authors.forename: Shigeyasu
authors.initials: S
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D006367:HeLa Cells; D006801:Humans; D009687:Nuclear Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D017686:Oncorhynchus mykiss / Q000235:genetics / Q000502:physiology*; D009928:Organ Specificity / Q000235:genetics; D010802:Phylogeny; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*
chemical_list: D009687:Nuclear Proteins; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors