Ventriculoperitoneal shunt in patients with leptomeningeal metastasis.
The authors reviewed 37 patients with leptomeningeal metastasis (LM) who required a ventriculoperitoneal shunt (VP shunt) for management of intracranial hypertension. Improvement was seen in 27 (77%) patients; subdural hematoma developed in one and shunt malfunction in three. Median overall survival was 2 months (range 2 days to 3.6 years) after VP shunt placement, but there was no procedure-related mortality. The prognosis of LM remained poor, but VP shunt can be an effective palliative tool when required.
Omuro
Antonio M P
AM
Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Lallana
Enrico C
EC
Bilsky
Mark H
MH
DeAngelis
Lisa M
LM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D001932:Brain Neoplasms / Q000556:secondary; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy; D002277:Carcinoma / Q000150:complications* / Q000556:secondary; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D019586:Intracranial Hypertension / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D008175:Lung Neoplasms / Q000473:pathology / Q000532:radiotherapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000150:complications* / Q000556:secondary; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000473:pathology / Q000503:physiopathology*; D010166:Palliative Care / Q000592:standards / Q000639:trends; D011379:Prognosis; D013346:Subarachnoid Space / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D015996:Survival Rate; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D017287:Ventriculoperitoneal Shunt / Q000592:standards* / Q000639:trends