title: Relation of acute pericardial disease to malignancy.
abstract: Neoplastic etiology was found in 33 of 450 patients with acute pericardial disease (7.3%). Acute pericardial disease was the first manifestation of previously unknown malignancies in 18 of 450 patients (4.0%), and lung cancer was the most common malignancy (72.2%, p = 0.02). The following clinical characteristics were associated with a greater probability of a neoplastic etiology: a history of malignancy (odds ratio [OR] 19.8), cardiac tamponade at presentation (OR 7.0), a lack of response to nonsteroidal anti-inflammatory drugs, and recurrent or incessant pericarditis (OR 10.0). A similar prognosis was found in patients with or without a history of known cancer.
authors.affiliation: Cardiology Department, Maria Vittoria Hospital, Torino, Italy. imazio@tin.it
authors.forename: Massimo
authors.initials: M
authors.lastname: Imazio
authors.forename: Brunella
authors.initials: B
authors.lastname: Demichelis
authors.forename: Iris
authors.initials: I
authors.lastname: Parrini
authors.forename: Elisa
authors.initials: E
authors.lastname: Favro
authors.forename: Federico
authors.initials: F
authors.lastname: Beqaraj
authors.forename: Enrico
authors.initials: E
authors.lastname: Cecchi
authors.forename: Franco
authors.initials: F
authors.lastname: Pomari
authors.forename: Daniela
authors.initials: D
authors.lastname: Demarie
authors.forename: Aldo
authors.initials: A
authors.lastname: Ghisio
authors.forename: Riccardo
authors.initials: R
authors.lastname: Belli
authors.forename: Marco
authors.initials: M
authors.lastname: Bobbio
authors.forename: Rita
authors.initials: R
authors.lastname: Trinchero
mesh_terms: D000208:Acute Disease; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002305:Cardiac Tamponade / Q000150:complications; D005260:Female; D006331:Heart Diseases / Q000209:etiology; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications*; D010496:Pericardium; D011379:Prognosis; D011446:Prospective Studies; D012008:Recurrence
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal