[Pregna-D'-pentaranes--progestins and antiprogestins: I. Differentiation of biological functions of steroid hormones].
The synthesis, modification, structure, and biological activity in vivo of the 16alpha,17alpha-cycloalkanoprogesterone (pregna-D'-pentarane) analogues of progesterone are described. A possibility of separation of their biological functions has been demonstrated. A systematic synthesis of a set of uniform compounds that differ in a limited number of alterable parameters was developed. It resulted in an instrument useful for the investigation of pathways and mechanisms by which the steroid hormones fulfill their biological functions and for the probable discovery of new functions masked by the wide effects of native compounds.
Kamernitskiĭ
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Levina
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D000818:Animals; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology*; D008297:Male; D011374:Progesterone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D011372:Progestins / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D012739:Gonadal Steroid Hormones; D011372:Progestins; D011374:Progesterone