[Influence of UV-light and dexamethasone on functional properties of lymphocytes and neutrophils].
UV-light and dexamethasone influence on functional properties of lymphocytes and neutrophils of peripherical donors' blood was studied. An increase of phagocytic activity of neutrophils was observed after their incubation with photomodified lymphocytes. It was found that UV-irradiation of lymphocytes activated synthesis of interleukines 1beta and 2. Dexamethasone presence in lymphocyte suspension inhibited the synthesis of the studied cytokines, especially by the incubation with photomodified cells. It was shown by the method of fluorescent labels that UV-irradiation improved interaction between dexamethasone and cell membrane.
Artiukhov
V G
VG
Basharina
O V
OV
Lialina
I E
IE
Maslov
O V
OV
D000328:Adult; D001782:Blood Donors; D002462:Cell Membrane / Q000187:drug effects; D016207:Cytokines / Q000096:biosynthesis; D003627:Data Interpretation, Statistical; D003907:Dexamethasone / Q000494:pharmacology*; D005938:Glucocorticoids / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D015227:Lipid Peroxidation; D008163:Luminescent Measurements; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism / Q000528:radiation effects*; D010587:Phagocytosis; D011829:Radiation Dosage; D013997:Time Factors; D014466:Ultraviolet Rays
D016207:Cytokines; D005938:Glucocorticoids; D007375:Interleukin-1; D007376:Interleukin-2; D003907:Dexamethasone