Dendritic cells maximize the memory CD8 T cell response to infection.
Costimulatory signals from dendritic cells (DCs) are required for naive T cells to respond to antigenic stimulation. To what extent DCs reactivate memory T cells during recall responses is not known. Here, an in vivo depletion system has been used to analyze the role of DCs in reactivating CD8 memory T cells during recall responses to three different microbial infections. We show a profound decrease in the numbers of responding memory CD8 T cells in both lymphoid and nonlymphoid tissues during the recall responses to infection with vesicular stomatitis virus, Listeria monocytogenes (Lm), or influenza virus. These data show that interaction with DCs is a major mechanism driving T cell reactivation in vivo, even during a tissue-specific infection of the respiratory tract.
Zammit
David J
DJ
Division of Immunology, University of Connecticut Health Center, Farmington, CT 06030, USA.
Cauley
Linda S
LS
Pham
Quynh-Mai
QM
Lefrançois
Leo
L
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002678:Chimera / Q000235:genetics / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D049452:Green Fluorescent Proteins / Q000235:genetics; D066257:Heparin-binding EGF-like Growth Factor; D007156:Immunologic Memory; D007239:Infections / Q000276:immunology*; D036341:Intercellular Signaling Peptides and Proteins; D008088:Listeriosis / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009976:Orthomyxoviridae Infections / Q000276:immunology; D010047:Ovalbumin / Q000276:immunology; D011956:Receptors, Cell Surface / Q000235:genetics; D018353:Rhabdoviridae Infections / Q000276:immunology; D015398:Signal Transduction; D014721:Vesicular stomatitis Indiana virus
C587884:Hbegf protein, mouse; D066257:Heparin-binding EGF-like Growth Factor; D036341:Intercellular Signaling Peptides and Proteins; D011956:Receptors, Cell Surface; D049452:Green Fluorescent Proteins; D010047:Ovalbumin