Syntheses and anti-inflammatory activity of diphenylamine-2,2'-dicarboxylic acid and its metal complexes.
Diphenylamine-2,2'-dicarboxylic acid and its Cu(II), Ni(II), Co(II) and Zn(II) complexes have been synthesized and characterized by their elemental analyses, molecular weight determination, molar conductance, infrared and electronic spectra and magnetic measurements. The Zinc complex was tested by different methods for its anti-inflammatory activity and found to be equipotent to naproxen and ibuprofen, though at higher doses.
Mohan
Govind
G
Department of Pharmacology, S.N. Medical College, Agra-282 002, India. rohit210477@rediffmail.com
Nagar
Rajesh
R
Agarwal
S C
SC
Mehta
Km Anugya
KA
Rao
C Sheshagiri
CS
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology*; D016718:Arachidonic Acid / Q000633:toxicity; D001169:Arthritis, Experimental / Q000188:drug therapy; D002351:Carrageenan / Q000633:toxicity; D003436:Croton Oil / Q000633:toxicity; D003967:Diarrhea / Q000139:chemically induced / Q000188:drug therapy; D004159:Diphenylamine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D006099:Granuloma / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D019216:Metals, Heavy / Q000737:chemistry*; D051379:Mice; D008970:Molecular Weight; D011453:Prostaglandins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014456:Ulcer / Q000188:drug therapy
D000894:Anti-Inflammatory Agents, Non-Steroidal; D019216:Metals, Heavy; D011453:Prostaglandins; D016718:Arachidonic Acid; D003436:Croton Oil; D002351:Carrageenan; D004159:Diphenylamine