title: Suitability of radiochromic medium for real-time optical measurements of ionizing radiation dose.
abstract: A system, consisting of a novel optical fiber-based readout configuration and model-based method, has been developed to test suitability of a certain radiochromic medium for real-time measurements of ionizing radiation dose. Using this system with the radiochromic film allowed dose measurements to be performed during, and immediately after, exposure. The rates of change in OD before, during, and after exposure differ, and the change in OD during exposure was found to be proportional to applied dose in the tested range of 0-4 Gy. Estimating applied dose within an average error of less than 5% did not require a waiting time of 24-48 h as generally recommended with this radiochromic film. The errors can be further reduced by performing a calibration for each individual dosimeter setup instead of relying on batch calibration. Measurements of change in OD were found to be independent of dose-rate in the 95-570 cGy/min range for applied dose of 1 Gy or less. Some error was introduced due to dose-rate variation for doses of 2 Gy and above. The major limiting factor in utilizing this radiation sensitive medium for real-time in vivo dosimetry is the strong dependence on temperature in the clinically relevant range of 20-38 degrees C.
authors.affiliation: Princess Margaret Hospital/Ontario Cancer Institute, Department of Medical Biophysics and Radiation Oncology, University of Toronto, Toronto, Ontario M5G 2M9, Canada. alex.rink@rmp.uhn.on.ca
authors.forename: Alexandra
authors.initials: A
authors.lastname: Rink
authors.forename: I Alex
authors.initials: IA
authors.lastname: Vitkin
authors.forename: David A
authors.initials: DA
authors.lastname: Jaffray
mesh_terms: D000114:Acetylene / Q000737:chemistry; D002138:Calibration; D004307:Dose-Response Relationship, Radiation; D004583:Electrons; D005373:Film Dosimetry; D019047:Phantoms, Imaging; D017785:Photons; D011108:Polymers / Q000737:chemistry; D011839:Radiation, Ionizing; D011874:Radiometry / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D012680:Sensitivity and Specificity; D013053:Spectrophotometry / Q000379:methods; D013696:Temperature; D013997:Time Factors; D014466:Ultraviolet Rays; D014962:X-Ray Film
chemical_list: D011108:Polymers; D000114:Acetylene