Evaluation of natural coagulation inhibitor levels in various hypertensive states of pregnancy.
OBJECTIVE
To evaluate the role of natural coagulation inhibitors in various classifications of pregnancy associated hypertension in Turkish population living in Trakya region of Turkey.


METHODS
Serum uric acid levels, plasma protein C (PC), protein S (PS), antithrombin III (AT III) activities and activated protein C resistance (APCR) were measured in 80 pregnant women with hypertension (preeclampsia, n = 32; severe preeclampsia, n = 25; eclampsia, n = 14; chronic hypertension, n = 9) and 58 healthy pregnant women. Tukey and Tamhane multiple comparison tests, Kruskal-Wallis, chi2 and Fisher's exact tests were performed for comparison of means and/or medians.


RESULTS
Serum uric acid levels were significantly elevated in women with preeclampsia and severe preeclampsia, but PS activity decreased in women with severe preeclampsia (33.2 +/- 18.9% versus 50.4 +/- 22.7%, p = 0.015) and chronic hypertension (29.5 +/- 14.5% versus 50.4+ /- 22.7%, p = 0.045) compared to healthy controls. There was no significant difference in APCR, and PC or AT III activity between the groups. Platelet counts were significantly lower in women with severe preeclampsia, compared to controls and women with chronic hypertension.


CONCLUSIONS
Serum uric acid levels and plasma protein S activity may be useful as indices of severity of pathology in pregnancy associated hypertension.
Sayin
Müge
M
State Hospital, Edirne, Turkey.
Varol
Füsun G
FG
Sayin
N Cenk
NC
D000328:Adult; D019774:Blood Coagulation Factor Inhibitors / Q000097:blood; D002908:Chronic Disease; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D046110:Hypertension, Pregnancy-Induced / Q000097:blood*; D010976:Platelet Count; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood; D017293:Protein S / Q000032:analysis*; D014421:Turkey; D014527:Uric Acid / Q000097:blood*
D019774:Blood Coagulation Factor Inhibitors; D017293:Protein S; D014527:Uric Acid