title: [Chlamydia infection in neonates and infants].
abstract: Incidence of chlamydial infection depends on maternal colonization during pregnancy, which is different in each population. The transmission is not obligatory but when present, it occurs at birth through the genital tractus. Chlamydia trachomatis infection is the first cause of neonatal conjunctivitis, with no influence of eye lotion application at birth. C. trachomatis is also responsible for interstitial pneumonia with possible consequences on the lung function. The laboratory diagnosis relies on the identification of intracellular bacteria in patient samples by the mean of culture or PCR. Systemic antibiotherapy by macrolides is always necessary, with local application in the case of conjunctivitis. The key point is the detection of colonization of pregnant women with identified risk factors. In positive case, oral treatment of both parents is recommended.
authors.affiliation: Unité de néonatologie B, hôpital Pellegrin-Enfants, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France. jean.sarlangue@chu-bordeaux.fr
authors.forename: J
authors.initials: J
authors.lastname: Sarlangue
authors.forename: C
authors.initials: C
authors.lastname: Castella
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002689:Chlamydia / Q000472:pathogenicity*; D002690:Chlamydia Infections / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology*; D003231:Conjunctivitis / Q000209:etiology*; D004269:DNA, Bacterial; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases; D018445:Infectious Disease Transmission, Vertical; D018942:Macrolides / Q000627:therapeutic use*; D008297:Male; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D012307:Risk Factors
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D018942:Macrolides