title: Role of cytokines in experimental and clinical uveitis.
abstract: Uveitis is a major cause of visual impairment. Experimental autoimmune uveitis mimics the clinical conditions of posterior uveitis in many ways. T-cells (particularly CD4+ helper-T-cells) have been shown to play an important role in pathogenesis of experimental and clinical uveitis. Based on the pattern of cytokine they secrete, CD4+ helper cells have been divided into Th1 and Th2 subsets. Various Th1 and Th2 cytokines appear to be involved in the pathogenesis and/or recovery from uveitis. This article discusses in detail the uveitopathogenic and therapeutic potential of Th1 and Th2 cytokines in experimental and clinical uveitis.
authors.affiliation: Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. vksingh@sgpgi.ac.in
authors.forename: V K
authors.initials: VK
authors.lastname: Singh
authors.forename: G
authors.initials: G
authors.lastname: Rai
authors.forename: S S
authors.initials: SS
authors.lastname: Agarwal
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D016207:Cytokines / Q000627:therapeutic use*; D004195:Disease Models, Animal; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D051381:Rats; D014605:Uveitis / Q000188:drug therapy*
chemical_list: D016207:Cytokines; D007166:Immunosuppressive Agents