title: A case of symptomatic primary HIV infection.
abstract: A 30-year-old homosexual Japanese man had fourteen days of fever, malaise, appetite loss, sore throat, and four days of diarrhea and slightly congested eyes before he developed a skin eruption. He presented with measles-like exanthems on his face, trunk, and extremities. Deep red enanthems were seen on his left buccal mucosa opposite the premolar teeth, and whitish enanthems were seen on the buccal and gingival mucosa. HIV RNA was detected at the high concentration of 5.8 x 10(6) copies /ml in his serum. Cerebrospinal fluid examination revealed aseptic meningitis with 5,488 copies /ml of HIV RNA. Anti-HIV 1 antibodies against Gp160 and p24 tested by Western blot assay showed seroconversion on day 5 of his admission, seven days after he developed the skin eruptions. The fever lasted for three weeks from the initial onset, and the skin eruptions lasted for twelve days. Histopathologically, a mononuclear cell infiltration was seen mainly in the upper dermis surrounding small vessels and sweat ducts, with CD8+ cytotoxic T lymphocytes predominant. Additionally, CD1a+ putative interdigitating dendritic cells had also infiltrated perivascularly, and were surrounded by CD8+ and CD4+ T cells. In situ hybridization study failed to detect HIV products in skin biopsy specimens. Our findings suggested that CD8+ T cells and their interaction with CD1a+ dendritic cells in the skin may be important in inducing skin manifestations in acute HIV infections.
authors.affiliation: Department of Dermatology, Tokyo Women's Medical University, 8-1 Kawadacho, Shinjuku-ku, Tokyo 162-8666, Japan.
authors.forename: Satomi
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Satoko
authors.initials: S
authors.lastname: Segawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Kawashima
authors.forename: Ichiro
authors.initials: I
authors.lastname: Itoda
authors.forename: Takako
authors.initials: T
authors.lastname: Shima
authors.forename: Mitsunobu
authors.initials: M
authors.lastname: Imai
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005076:Exanthema / Q000209:etiology*; D015483:HIV Antibodies / Q000032:analysis; D015658:HIV Infections / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D006679:HIV Seropositivity; D015497:HIV-1 / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D009059:Mouth Diseases / Q000209:etiology* / Q000473:pathology; D012367:RNA, Viral / Q000032:analysis
chemical_list: D015483:HIV Antibodies; D012367:RNA, Viral