title: Does the imaging method have an influence on the measured tumor height in ruthenium plaque therapy of uveal melanoma?
abstract: OBJECTIVE
  For ruthenium plaque therapy of uveal melanoma the precise knowledge of the tumor height is necessary. The purpose of this analysis is to examine systematic differences between ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI) measurements of tumor height in uveal melanoma.
  
  
  METHODS
  From 1993 to 2000, 208 patients with uveal melanoma were treated with ruthenium therapy. US was done in 190/208 patients, CT in 147/208 patients, and MRI in 81/208 patients. The measurements from the imaging modalities were compared to each other. Separate comparisons were carried out for tumor size and localization and between two-dimensional (2-D) and three-dimensional (3-D) measurements in reconstructed planes.
  
  
  RESULTS
  In direct comparison, CT measurements (median: 4.5 mm; range: 1.6-10.5 mm) were nearly identical to MRI measurements (median: 4.5 mm; range: 2.0-11.4 mm), while US yielded the highest values (median: 5.2 mm; range: 2.5-13.4 mm). Linear regression yielded the following values: CT versus US (R(2) = 0.88, correlation coefficient = 1.04), MRI versus US (R(2) = 0.79, correlation coefficient = 0.92), MRI versus CT (R(2) = 0.84, correlation coefficient = 0.90), and "2-D" versus reconstructed "3-D" (R2 = 0.93, correlation coefficient = 0.98).
  
  
  CONCLUSIONS
  Differences between the measurements from all three modalities were generally acceptable, except for small tumors (< or =4 mm; limited spatial resolution of CT/MRI) and temporal or peripheral lesions (angular distortion in US). In special anatomic situations, CT/MRI measurements can also result in distortions. "3-D" measurements can sometimes help in these situations.
authors.affiliation: Department of Radiotherapy and Radiation Oncology, University of Münster, Germany. pschuel@uni-muenster.de
authors.forename: Patrick
authors.initials: P
authors.lastname: Schueller
authors.forename: Adnan
authors.initials: A
authors.lastname: Dogan
authors.forename: Joan E
authors.initials: JE
authors.lastname: Panke
authors.forename: Oliver
authors.initials: O
authors.lastname: Micke
authors.forename: Normann
authors.initials: N
authors.lastname: Willich
mesh_terms: D001918:Brachytherapy / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008545:Melanoma / Q000473:pathology / Q000532:radiotherapy*; D012189:Retrospective Studies; D012429:Ruthenium Radioisotopes / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D014604:Uveal Neoplasms / Q000473:pathology / Q000532:radiotherapy*
chemical_list: D012429:Ruthenium Radioisotopes