title: Synaptic depression as a timing device.
abstract: A depressing synapse transforms a time interval into a voltage amplitude. The effect of that transformation on the output of the neuron and network depends on the kinetics of synaptic depression and properties of the postsynaptic neuron and network. Using as examples neural circuits that incorporate depressing synapses, we show how short-term depression can contribute to a surprising variety of time-dependent computational and behavioral tasks.
authors.affiliation: Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA.
authors.forename: Lucinda A
authors.initials: LA
authors.lastname: Grande
authors.forename: William J
authors.initials: WJ
authors.lastname: Spain
mesh_terms: D000818:Animals; D036881:Long-Term Synaptic Depression / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology*; D010507:Periodicity; D013017:Sound Localization / Q000502:physiology; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*