title: Polyethylene wear rate and osteolysis: critical threshold versus continuous dose-response relationship.
abstract: We studied the relationship between polyethylene wear and osteolysis in 230 subjects after cemented Charnley total hip arthroplasty in order to examine the validity of the wear rate threshold concept. Polyethylene wear measured using image analysis (EBRA) software was compared in 115 subjects with osteolysis versus 115 control subjects that were individually matched for age, sex, and follow up period. Subjects with osteolysis had almost twice the mean annual wear rate versus the controls. The incidence of osteolysis increased in a linear manner with each quintile increase in wear rate throughout the range 0.01-0.54 mm/year. The odds-ratio for osteolysis approximately doubled with each quintile increase in wear rate above the middle quintile (wear rate 0.08-0.11 mm/year), and decreased at a similar rate with each quintile decrease in wear rate below the middle quintile. Our data suggests that the association of osteolysis with polyethylene wear rate represents a continuous dose-response relationship and does not support the concept of a discrete critical wear rate threshold above which the risk of osteolysis is disproportionately increased.
authors.affiliation: Lower Limb Arthroplasty Unit, Department of Orthopaedics, Northern General Hospital, Sheffield, UK. wilkomark@aol.com
authors.forename: J Mark
authors.initials: JM
authors.lastname: Wilkinson
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Hamer
authors.forename: Ian
authors.initials: I
authors.lastname: Stockley
authors.forename: Richard
authors.initials: R
authors.lastname: Eastell
mesh_terms: D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010014:Osteolysis / Q000209:etiology*; D011095:Polyethylenes
chemical_list: D011095:Polyethylenes