title: New cyclomaltoheptaose (beta-cyclodextrin) derivative 2-O-(2-hydroxybutyl)cyclomaltoheptaose: preparation and its application for the separation of enantiomers of drugs by capillary electrophoresis.
abstract: A new soluble cyclomaltoheptaose (cyclodextrin) derivative, 2-O-(2-hydroxybutyl)cyclomaltoheptaose [2-O-(2-hydroxybutyl)-beta-cyclodextrin, 2-HB-beta-CD], was prepared and studied as an efficient chiral selector in the separation of racemic mixtures of drugs by capillary electrophoresis (CE). Results showed that 2-HB-beta-CD could provide higher separating capability than that of beta-CD and the similarly substituted 2-HP-beta-CD.
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University, Jinan, PR China.
authors.forename: Ming-gang
authors.initials: MG
authors.lastname: Zhao
authors.forename: Ai-you
authors.initials: AY
authors.lastname: Hao
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Yun-he
authors.initials: YH
authors.lastname: Wei
authors.forename: Peng
authors.initials: P
authors.lastname: Guo
mesh_terms: D019075:Electrophoresis, Capillary; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000302:isolation & purification*; D013237:Stereoisomerism; D047392:beta-Cyclodextrins / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: C504609:2-O-(2-hydroxybutyl)cyclomaltoheptaose; D004364:Pharmaceutical Preparations; D047392:beta-Cyclodextrins