title: 2-Methoxy-6-oxo-1,4,5,6-tetrahydropyridine-3-carbonitriles: versatile starting materials for the synthesis of libraries with diverse heterocyclic scaffolds.
abstract: Heterocyclic demonstration libraries for agrochemical screening were prepared from the common intermediates 2-methoxy-6-oxo-1,4,5,6-tetrahydropyridine-3-carbonitriles (1), using standard solution-phase techniques. A total of 18 screening libraries were prepared in good to excellent yields. Several members of these libraries were active in the first level of agrochemical screening, especially in the fungicide screen.
authors.affiliation: Grup d'Enginyeria Molecular, Institut Químic de Sarrià, Universitat Ramon Llull, Via Augusta, 390, E-08017 Barcelona, Spain.
authors.forename: Blanca
authors.initials: B
authors.lastname: Martínez-Teipel
authors.forename: Jordi
authors.initials: J
authors.lastname: Teixidó
authors.forename: Rosalia
authors.initials: R
authors.lastname: Pascual
authors.forename: Marta
authors.initials: M
authors.lastname: Mora
authors.forename: Josep
authors.initials: J
authors.lastname: Pujolà
authors.forename: Ted
authors.initials: T
authors.lastname: Fujimoto
authors.forename: José I
authors.initials: JI
authors.lastname: Borrell
authors.forename: Enrique L
authors.initials: EL
authors.lastname: Michelotti
mesh_terms: D002626:Chemistry, Pharmaceutical; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D004353:Drug Evaluation, Preclinical; D005659:Fungicides, Industrial / Q000032:analysis / Q000494:pharmacology; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D008970:Molecular Weight; D009570:Nitriles / Q000737:chemistry*; D011728:Pyridones / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D005659:Fungicides, Industrial; D006571:Heterocyclic Compounds; D009570:Nitriles; D011728:Pyridones