Molecular epidemiology and KSHV K1 subtypes in a Cuban AIDS-Kaposi's sarcoma population.
Kaposi's sarcoma-associated herpesvirus (KSHV) is detected consistently in Kaposi's sarcoma (KS). Because of its dramatic sequence variation, the K1 gene has been used to classify KSHV. We found a diverse array of KSHV subtypes A1, A2, A3, A5, B1, B2, and C3 in 23 Cuban KS samples containing several novel sporadic insertions/deletions in subtypes A and C. The molecular epidemiology of the KSHV subtypes seems to reflect the unique mixed ethnic background of the Cuban population.
Kouri
Vivian
V
Department of Virology, Institute of Tropical Medicine Pedro Kouri, Havana City, Cuba.
Liang
Xiaozhen
X
Rodriguez
Maria Elena
ME
Capo
Virginia
V
Resik
Sonia
S
Barrios
Julio
J
Mantecon
Beatriz
B
Blanco
Orestes
O
Means
Robert
R
Jung
Jae U
JU
Lee
Bok-Soo
BS
Hengge
Ulrich R
UR
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000595:Amino Acid Sequence; D003462:Cuba / Q000453:epidemiology; D005260:Female; D005814:Genes, Viral; D019288:Herpesvirus 8, Human / Q000145:classification* / Q000235:genetics; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D012514:Sarcoma, Kaposi / Q000453:epidemiology / Q000821:virology*