[Matrilysin-1 and cancer pathology].
Matrilysin-1 has a considerable importance in the progression of cancers, namely digestive, ones inasmuch as it fulfils a direct function of deterioration on molecular targets at different levels and interferes as well in the activation of other proteolytic systems. Its low expression in sound tissues increases distinctly in mild cellular proliferations like adenomas to increase even more in carcinomas and be involved at the level of tumoral development as well as in a metastatical proliferation. It acts during the different stages of malignant transformation, splitting the E-cadherin, an intercellular adhesive molecule of epithelia, matrix molecules in the tumor-stroma interface and integrins which link matrix components to epithelial cells. The use of oligonucleotide antisens to the matrilysin-1 drives to a clear reduction of invading process, suggesting therefore an important therapeutic potential.
Rémy
Lionel
L
Inserm U.45, IFR62, Université Lyon 1, Faculté de Médecine Laennec, 7, rue Guillaume Paradin, 69372 Lyon Cedex 08, France. remy@lyon.inserm.fr
Trespeuch
Cécile
C
D006801:Humans; D020783:Matrix Metalloproteinase 7 / Q000502:physiology*; D009369:Neoplasms / Q000209:etiology*; D011506:Proteins / Q000502:physiology*
D011506:Proteins; C060932:MMP7 protein, human; D020783:Matrix Metalloproteinase 7