title: Synthesis of mixed esters of ascorbic acid using methyl esters of palm and soybean oils.
abstract: Mixed esters of ascorbic acid were synthesized using methyl esters of palm and soybean oils as acyl donors, in acetone at 50 degrees C, and catalyzed by Novozym 435. A conversion of 62% was obtained with palm oil methyl ester at an ascorbic acid to acyl donor molar ratio of 1:4; the mixed ester contained 45.89% ascorbyl palmitate, 42.59% ascorbyl oleate and 10.1% ascorbyl linoleate. Acylation with soybean oil methyl ester resulted in 17% conversion, yielding a mixed ester containing 10.08% ascorbyl palmitate, 20.68% ascorbyl oleate, and 64.96% of ascorbyl linoleate. The mixed esters of ascorbic acid can find direct use in food and cosmetics.
authors.affiliation: Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan.
authors.forename: Hsin-Ju
authors.initials: HJ
authors.lastname: Hsieh
authors.forename: Jech-Wei
authors.initials: JW
authors.lastname: Chen
authors.forename: R
authors.initials: R
authors.lastname: Giridhar
authors.forename: Wen-Teng
authors.initials: WT
authors.lastname: Wu
mesh_terms: D001205:Ascorbic Acid / Q000138:chemical synthesis*; D004800:Enzymes, Immobilized; D004952:Esters / Q000138:chemical synthesis; D005240:Feasibility Studies; D005656:Fungal Proteins; D008049:Lipase / Q000737:chemistry*; D008745:Methylation; D000073878:Palm Oil; D010938:Plant Oils / Q000737:chemistry*; D013024:Soybean Oil / Q000737:chemistry*; D013379:Substrate Specificity
chemical_list: D004800:Enzymes, Immobilized; D004952:Esters; D005656:Fungal Proteins; D010938:Plant Oils; D000073878:Palm Oil; D013024:Soybean Oil; C093667:Novozyme 435; D008049:Lipase; D001205:Ascorbic Acid