title: [Problems and outlooks for the preventive treatment of retinopathy in prematures].
abstract: The immediate and remote (up to 7 years) results of preventive cryo- and/or lasercoagulation of avascular retinal zones made in 390 children with active progressing retinopathy of prematures (RP) were analyzed. The efficiency of cryocoagulation in processes localized in zones 2-3 of the eye bottom made 92%, and that of the combined technique (laser- and cryocoagulation) with lesions in zones 1-2 and with plus-diseases was up to 80%. The preventive treatment is indicated for the 3d threshold (ordinary clinical course) and before-threshold (with plus-disease and localization zone 1) stages. Such treatment is not justified when undertaken early and in developed retinal detachment. Further research of the disease pathogenesis is needed to enhance the efficiency of the RP treatment, i.e. research of growth factors of endothelial vessels, autoimmune reaction to S-antigen of the retina and of dosed oxygentherapy etc.
authors.forename: L A
authors.initials: LA
authors.lastname: Katargina
authors.forename: A V
authors.initials: AV
authors.lastname: Khvatova
authors.forename: L V
authors.initials: LV
authors.lastname: Kogoleva
authors.forename: E V
authors.initials: EV
authors.lastname: Denisova
mesh_terms: D003452:Cryosurgery / Q000639:trends*; D018450:Disease Progression; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D017075:Laser Coagulation / Q000639:trends*; D012029:Refraction, Ocular / Q000502:physiology; D012160:Retina / Q000473:pathology / Q000601:surgery; D012178:Retinopathy of Prematurity / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D016896:Treatment Outcome