title: Stochastic frequency signature for chemical sensing using noninvasive neuronelectronic interface.
abstract: The detection of chemical agents is important in many areas including environmental pollutants, toxins, biological and chemical pollutants. As "smart" cells, with strong information encoding ability, neurons can be treated as independent sensing elements. A hybrid circuit of a semiconductor chip with dissociated neurons formed both sensors and transducers. Stochastic frequency spectrum was used to differentiate a mixture of chemical agents with effect on the opening of different ion channels. The frequency of spike trains revealed the concentration of the chemical agent, where the characteristic tuning curve revealed the identity. "Fatigue" experiment was performed to explore the "refreshing" ability and "memory" effect of neurons by cyclic and cascaded sensing. "Neuronelectronic noses" such as this should have wide potential applications, most notably in environmental and medical monitoring.
authors.affiliation: Department of Mechanical Engineering and University of California, Riverside, CA 92521-0123, USA.
authors.forename: Mo
authors.initials: M
authors.lastname: Yang
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Cengiz S
authors.initials: CS
authors.lastname: Ozkan
mesh_terms: D000200:Action Potentials / Q000187:drug effects* / Q000502:physiology*; D000465:Algorithms; D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation*; D018929:Cell Culture Techniques / Q000295:instrumentation* / Q000379:methods; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004581:Electronics; D004867:Equipment Design; D019544:Equipment Failure Analysis; D000431:Ethanol / Q000494:pharmacology; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects / Q000196:embryology / Q000502:physiology; D006861:Hydrogen Peroxide / Q000494:pharmacology; D008839:Microelectrodes; D008959:Models, Neurological; D015233:Models, Statistical; D009474:Neurons / Q000187:drug effects* / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013269:Stochastic Processes; D014159:Transducers
chemical_list: D000431:Ethanol; D006861:Hydrogen Peroxide