title: Use of bioelectrical impedance analysis to determine body composition changes in HIV-associated wasting.
abstract: AIDS wasting syndrome results in loss of lean body mass and body cell mass. This 12-week, open-label study used bioelectrical impedance analysis to measure body composition changes in 24 patients with AIDS wasting syndrome receiving recombinant human growth hormone (r-hGH). The primary endpoint was percentage monthly change in body weight before/after r-hGH. Secondary endpoints included change from baseline in body composition (bioelectrical impedance analysis), isometric strength and CD4+ count. Twenty patients completed the study: r-hGH resulted in mean weight gains (+2.7%, P = 0.146), and significant increases in mean body cell mass (+8.0%, P = 0.0211), lean body mass (+4.8%, P = 0.0373) and water (+5.5%, P < 0.023). Body fat decreased throughout, but not significantly. r-hGH was generally well tolerated; the most frequent adverse events were fever (7.3%) and diarrhoea (6.3%). Thus, bioelectrical impedance analysis can detect improved body cell mass independent of changes in body weight resulting from r-hGH treatment in patients with AIDS wasting syndrome.
authors.affiliation: HIV-Schwerpunktpraxis, Frankfurt, Germany. stklauke@aol.com
authors.forename: Stephan
authors.initials: S
authors.lastname: Klauke
authors.forename: Harald
authors.initials: H
authors.lastname: Fischer
authors.forename: Armin
authors.initials: A
authors.lastname: Rieger
authors.forename: Lukas
authors.initials: L
authors.lastname: Frühauf
authors.forename: Schlomo
authors.initials: S
authors.lastname: Staszewski
authors.forename: Peter-Henning
authors.initials: PH
authors.lastname: Althoff
authors.forename: Eilke Brigitte
authors.initials: EB
authors.lastname: Helm
mesh_terms: D000328:Adult; D000368:Aged; D001823:Body Composition; D017097:Electric Impedance; D019247:HIV Wasting Syndrome / Q000175:diagnosis* / Q000188:drug therapy*; D018737:Hand Strength; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged
chemical_list: D019382:Human Growth Hormone