Serum growth hormone and insulin-like growth factor-1 concentrations in Japanese black cattle with renal tubular dysplasia.
To elucidate the cause of growth retardation, 14 cattle with renal tubular dysplasia (RTD) were investigated by determining serum growth hormone (GH) and insulin-like growth factor (IGF)-1 concentrations. Compared with 6 healthy cattle, the baseline, maximum, area under the curve and peak amplitude of serum GH concentrations were higher or tended to be higher. Serum IGF-1 concentrations were lower normal or lower in cattle with RTD than in healthy cattle. Serum IGF-1 concentrations correlated significantly with body weight and chest girth, but not with serum GH and creatinine concentrations. Growth retardation in RTD might be associated partially with GH resistance.
Nishii
Naohito
N
Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Japan.
Ohba
Yasunori
Y
Takasu
Masaki
M
Katoh
Kazuo
K
Kitoh
Katsuya
K
Sasaki
Yoshihide
Y
Kitagawa
Hitoshi
H
D000818:Animals; D049628:Body Size; D001835:Body Weight; D002417:Cattle; D002418:Cattle Diseases / Q000378:metabolism*; D006130:Growth Disorders / Q000097:blood / Q000150:complications / Q000662:veterinary*; D013006:Growth Hormone / Q000097:blood*; D007564:Japan; D007674:Kidney Diseases / Q000097:blood / Q000150:complications / Q000662:veterinary*; D013002:Somatomedins / Q000378:metabolism*
D013002:Somatomedins; D013006:Growth Hormone