title: IgG neuropathy: an immunoelectron microscopic study.
abstract: There are many potential mechanisms of peripheral nerve impairment by a monoclonal IgG dysglobulinemia. In this study, using electron microscopy, we observed widening of the myelin lamellae comparable to that commonly described in IgM neuropathies with antimyelin-associated glycoprotein activity. Such features have yet to be described in IgG neuropathies. In addition, we observed deposits of a granular material in the interstitial tissue of the nerve. By immunoelectron microscopy, we demonstrated the presence of the IgG in the lesions of myelin and the endoneurial space. A direct link between monoclonal dysglobulinemia (regardless of type) and polyneuropathy should be confirmed by nerve biopsy, because the result may influence treatment.
authors.affiliation: Department of Neurology, University Hospital, 2 Avenue Martin Luther King, 87042 Limoges, France. vallat@unilim.fr
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Vallat
authors.forename: Laurent
authors.initials: L
authors.lastname: Magy
authors.forename: Philippe
authors.initials: P
authors.lastname: Sindou
authors.forename: Corinne
authors.initials: C
authors.lastname: Magdelaine
authors.forename: Didier
authors.initials: D
authors.lastname: Cros
mesh_terms: D000888:Antibodies, Anti-Idiotypic / Q000378:metabolism; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D016253:Microscopy, Immunoelectron / Q000379:methods*; D008875:Middle Aged; D009186:Myelin Sheath / Q000276:immunology / Q000648:ultrastructure; D011115:Polyneuropathies / Q000097:blood / Q000276:immunology / Q000473:pathology*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G