title: [Diagnostic evaluation of chronic inflammatory intestinal diseases in children and adolescents: MRI with true-FISP as new gold standard?].
abstract: OBJECTIVE
  To evaluate the impact of magnetic resonance imaging (MRI) with use of True-FISP sequences in the evaluation of inflammatory bowel-wall changes in children and adolescents with Crohn's disease. Furthermore, the diagnostic procedure in children and adolescents with chronic inflammatory bowel disease (IBD) will be discussed in light of the relevant literature.
  
  
  METHODS
  Twenty-four children and adolescents aged between 7 and 21 years with suspected or known IBD underwent MRI on a 1.5 T-scanner (Philips ACS-NT, Best, Netherlands). One hour after 1 l of a 2.5 % mannitol solution was given orally, MR imaging was performed using coronal HASTE-M2D, coronal fat-suppressed T2-TSE, axial dynamic T1-weighted GE-sequences before and after i. v.-contrast material injection (0.1 mmol/kg Gd-DTPA) and using a 2D-balanced-FFE-sequence (True-FISP) before and after i. v.-contrast material injection in coronal and axial planes. The MR-images were correlated with endoscopy and the clinical findings. In 14 patients, a recently performed conventional radiographic enteroclysis was available. Each performed MRI sequence was evaluated by three experienced radiologists regarding the sensitivity and specificity of each sequence in the detection of inflammatory bowel wall changes. In addition, the image quality was assessed regarding the different tissue contrasts and the susceptibility to artifacts. The distension of the bowel wall and the patients' acceptance of the MRI examination were recorded.
  
  
  RESULTS
  With a sensitivity in detecting inflammatory small bowel changes of 93.3 % (axial pre-contrast, coronal post-contrast) and 100 % (axial post-contrast, coronal pre-contrast), the True-FISP outnumbers the other performed sequences (T1 = 80 %, HASTE = 13.3 % and T2-TSE = 53.3 %). The difference between True-FISP and contrast-enhanced T1 was not statistically significant, whereas the difference between True-FISP and HASTE and T2-TSE, respectively, was statistically significant. The True-FISP sequences revealed a statistically significant superiority regarding the soft-tissue differentiation in comparison to all other performed MR-sequences. The distension of the bowel wall was good in all patients. The patients' acceptance of the MRI examination was excellent.
  
  
  CONCLUSIONS
  The described small bowel MRI examination is appropriate for children and adolescents. With the use of True-FISP sequences, it is a convincing method with an outstanding sensitivity in the diagnosis of IBD. Not least because of the lack of radiation exposure, small bowel MRI ought to replace conventional enteroclysis as a gold standard for IBD diagnosis in children and adolescents.
authors.affiliation: Klinik für Radiologische Diagnostik der RWTH Aachen. hohl@rad.rwth-aachen.de
authors.forename: C
authors.initials: C
authors.lastname: Hohl
authors.forename: P
authors.initials: P
authors.lastname: Haage
authors.forename: G A
authors.initials: GA
authors.lastname: Krombach
authors.forename: T
authors.initials: T
authors.lastname: Schmidt
authors.forename: M
authors.initials: M
authors.lastname: Ahaus
authors.forename: R W
authors.initials: RW
authors.lastname: Günther
authors.forename: G
authors.initials: G
authors.lastname: Staatz
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D016477:Artifacts; D002648:Child; D003287:Contrast Media; D003424:Crohn Disease / Q000175:diagnosis*; D003627:Data Interpretation, Statistical; D003937:Diagnosis, Differential; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D017060:Patient Satisfaction; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA