Cochlear function in mice following inhalation of brevetoxin-3.
Brevetoxin-3 was shown previously to adversely affect central auditory function in goldfish. The present study evaluated the effects of exposure to this agent on cochlear function in mice using the 2f(1)-f(2) distortion-product otoacoustic emission (DPOAE). Towards this end, inbred CBA/CaJ mice were exposed to a relatively high concentration of brevetoxin-3 (approximately=400 microg/m(3)) by nose-only inhalation for a 2-h period. Further, a subset of these mice received a second exposure a day later that lasted for an additional 4 h. Mice exposed only once for 2 h did not exhibit any notable cochlear effects. Similarly, mice exposed two times, for a cumulative dose of 6 h, exhibited essentially no change in DPOAE levels.
Benson
Janet M
JM
Lovelace Respiratory Research Institute, Albuquerque, NM, USA.
Stagner
Barden B
BB
Martin
Glen K
GK
Friedman
Melissa
M
Durr
Sarah E
SE
Gomez
Andrea
A
McDonald
Jacob
J
Fleming
Lora E
LE
Backer
Lorraine C
LC
Baden
Daniel G
DG
Bourdelais
Andrea
A
Naar
Jerome
J
Lonsbury-Martin
Brenda L
BL
D000161:Acoustic Stimulation; D000280:Administration, Inhalation; D000818:Animals; D003051:Cochlea / Q000187:drug effects*; D005260:Female; D018072:Hair Cells, Auditory, Outer / Q000187:drug effects*; D006309:Hearing / Q000187:drug effects*; D019570:Inhalation Exposure; D008387:Marine Toxins / Q000008:administration & dosage / Q000633:toxicity*; D051379:Mice; D008808:Mice, Inbred CBA; D035964:Oxocins / Q000008:administration & dosage / Q000633:toxicity*; D010469:Perceptual Distortion; D000095702:Polyether Toxins
D008387:Marine Toxins; D035964:Oxocins; C502852:brevetoxin 3, Karenia brevis; D000095702:Polyether Toxins