Regulation of growth factor signaling and cell cycle progression by cell adhesion and adhesion-dependent changes in cellular tension.
The proliferation of most non-transformed cell types requires cell adhesion and cellular tension as well as exposure to mitogenic growth factors. Integrins and cadherins provide the adhesion signals, which ultimately allow for the cytoskeletal changes that control cellular tension. This review discusses the roles of integrins, cadherins, and the actin cytoskeleton as mediators of the mechanical tension critical for growth factor-dependent signaling and cell cycle progression.
Walker
Janice L
JL
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, 19104-6084, USA.
Fournier
Alaina K
AK
Assoian
Richard K
RK
D000199:Actins / Q000502:physiology; D015820:Cadherins / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology; D002453:Cell Cycle / Q000502:physiology*; D006133:Growth Substances / Q000378:metabolism / Q000502:physiology*; D016023:Integrins / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D000199:Actins; D015820:Cadherins; D006133:Growth Substances; D016023:Integrins