[Study on high mobility group-1 protein in patients with multiple trauma].
OBJECTIVE
To study the change in serum high mobility group-1 (HMG-1) protein in patients with multiple trauma and determine its relationship to severity of trauma and multiple organ dysfunction syndrome (MODS).


METHODS
In 33 cases, HMG-1 levels were determined on 1, 3, 7 days after trauma respectively. The values of injury severity score (ISS), acute physiology and chronic health evaluation II (APACHE II) and systemic inflammatory response syndrome (SIRS) score were determined. Meanwhile, the occurrence of organ dysfunction was noted.


RESULTS
The level of serum HMG-1 in patients with multiple trauma was much higher than that of normal controls, and also in those with organ dysfunction. HMG-1 and APACHE II were positively correlated (r=0.495, P=0.016). The level of serum HMG-1 and APACHE II value were much higher in patients with organ dysfunction than those of normal organ function, but there was no significant difference in SIRS score between the two groups (P=0.105).


CONCLUSIONS
Serum HMG-1 increases in patients with trauma and is positively correlated with severity of trauma. Serial determination of HMG-1 is helpful to discover clinical infection earlier. HMG-1 can be used as a warning indicator of the onset of MODS.
Fei
Jun
J
Department of Trauma, Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China.
Yu
Hong-jun
HJ
Zhou
Jian
J
Huang
Xian-kai
XK
Liang
Hua-ping
HP
Jiang
Yao-guang
YG
D018806:APACHE; D000328:Adult; D005260:Female; D024243:HMGB1 Protein / Q000097:blood*; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology / Q000503:physiopathology; D009104:Multiple Trauma / Q000097:blood* / Q000150:complications; D011379:Prognosis; D055815:Young Adult
D024243:HMGB1 Protein