title: Enhanced serum cholesterol and triglyceride levels in bulimia nervosa: relationships to psychiatric comorbidity, psychopathology and hormonal variables.
abstract: Increased levels of cholesterol have been reported in patients with bulimia nervosa (BN), but all but one of the published studies were performed on non-fasting subjects, which limits the interpretation of this finding. Moreover, the relationships between serum lipids and comorbid psychiatric disorders or bulimic psychopathology have scarcely been investigated. We measured serum levels of total cholesterol, triglycerides, glucose, 17beta-estradiol and thyroid hormones in 75 bulimic women and 64 age-matched healthy females after an overnight fast. Compared with healthy women, bulimic patients exhibited significantly enhanced serum levels of cholesterol and triglycerides, but similar values of glucose, 17beta-estradiol, FT3 and FT4. No significant differences emerged in these variables between patients with or without comorbid depression, borderline personality disorder or lifetime anorexia nervosa. Circulating cholesterol was positively correlated to the patients' drive for thinness, ineffectiveness, enteroceptive awareness and impulse regulation sub-item scores of the Eating Disorder Inventory-2. These findings confirm that BN is associated with increased levels of serum lipids. This alteration may be involved in the pathophysiology of certain psychopathological characteristics of BN and cannot be explained by the co-occurrence of other psychiatric disorders.
authors.affiliation: Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie, 80138 Naples, Italy. monteri@tin.it
authors.forename: Palmiero
authors.initials: P
authors.lastname: Monteleone
authors.forename: Paolo
authors.initials: P
authors.lastname: Santonastaso
authors.forename: Marilena
authors.initials: M
authors.lastname: Pannuto
authors.forename: Angela
authors.initials: A
authors.lastname: Favaro
authors.forename: Lorenza
authors.initials: L
authors.lastname: Caregaro
authors.forename: Eloisa
authors.initials: E
authors.lastname: Castaldo
authors.forename: Tatiana
authors.initials: T
authors.lastname: Zanetti
authors.forename: Mario
authors.initials: M
authors.lastname: Maj
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000097:blood / Q000453:epidemiology / Q000523:psychology; D001786:Blood Glucose / Q000378:metabolism; D001883:Borderline Personality Disorder / Q000097:blood / Q000453:epidemiology / Q000523:psychology; D002032:Bulimia / Q000097:blood / Q000453:epidemiology* / Q000523:psychology; D002784:Cholesterol / Q000097:blood; D015897:Comorbidity; D003866:Depressive Disorder / Q000097:blood / Q000453:epidemiology / Q000523:psychology; D004958:Estradiol / Q000097:blood*; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000453:epidemiology* / Q000523:psychology; D015228:Hypertriglyceridemia / Q000097:blood / Q000453:epidemiology* / Q000523:psychology; D001523:Mental Disorders / Q000097:blood / Q000453:epidemiology* / Q000523:psychology; D010555:Personality Inventory / Q000706:statistics & numerical data; D011594:Psychometrics / Q000706:statistics & numerical data; D011599:Psychopathology; D012016:Reference Values; D013223:Statistics as Topic; D013974:Thyroxine / Q000097:blood*; D014280:Triglycerides / Q000097:blood; D014284:Triiodothyronine / Q000097:blood*
chemical_list: D001786:Blood Glucose; D014280:Triglycerides; D014284:Triiodothyronine; D004958:Estradiol; D002784:Cholesterol; D013974:Thyroxine