title: Imaging with radiolabelled monoclonal antibody (MUJ591) to prostate-specific membrane antigen in staging of clinically localized prostatic carcinoma: comparison with clinical, surgical and histological staging.
abstract: OBJECTIVE
  To evaluate the reliability of prostate scintigraphy using a radiolabelled antibody (MUJ591) raised against the external domain of prostate-specific membrane antigen (PSMA) in the staging of early prostate cancer.
  
  
  METHODS
  This was a prospective study of 16 patients who had radical retropubic prostatectomies (median PSA 9.75 ng/mL). All patients underwent PSMA imaging using MUJ591 radiolabelled with (99m)Tc using a photo-reduction technique.
  
  
  RESULTS
  The findings of prostate imaging and histology were identical in seven patients. Scans showed understaging and overstaging in six and three patients, respectively.
  
  
  CONCLUSIONS
  PSMA scintigraphy using (99m)Tc-labelled MUJ591 identifies the presence of prostate cancer, but is not sensitive in delineating micro-invasion of the capsule, seminal vesicles or bladder neck. As in other studies it seems to be useful in detecting prostate bed recurrence and distant micrometastasis.
authors.affiliation: Department of Urology, St Bartholomew's Hospital and Barts and the London Queen Mary School of Medicine and Dentistry, University of London, London, UK. vinod.nargund@bartsandthelondon. nhs.uk
authors.forename: Vinod
authors.initials: V
authors.lastname: Nargund
authors.forename: Dona
authors.initials: D
authors.lastname: Al Hashmi
authors.forename: Priya
authors.initials: P
authors.lastname: Kumar
authors.forename: Stephen
authors.initials: S
authors.lastname: Gordon
authors.forename: Ugo
authors.initials: U
authors.lastname: Otitie
authors.forename: David
authors.initials: D
authors.lastname: Ellison
authors.forename: Melvyn
authors.initials: M
authors.lastname: Carroll
authors.forename: Sohail
authors.initials: S
authors.lastname: Baithun
authors.forename: Keith E
authors.initials: KE
authors.lastname: Britton
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000528:radiation effects; D000954:Antigens, Surface / Q000276:immunology*; D043425:Glutamate Carboxypeptidase II / Q000276:immunology*; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods*; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013667:Technetium; D015021:Yttrium Radioisotopes
chemical_list: D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D015021:Yttrium Radioisotopes; D013667:Technetium; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II