title: The peptide route to multifunctional gold nanoparticles.
abstract: Extremely stable, peptide-capped gold nanoparticles with two different biomolecular recognition motifs expressed on their surface have been prepared, and their specific and selective binding to artificial, DNA-modified target particles and to DNA and protein microarrays has been demonstrated. Stabilization and biofunctionalization has been achieved in a single preparative step starting with citrate-stabilized gold hydrosols and a derivatization cocktail of peptide-capping ligands, which carry the functionalities of choice.
authors.affiliation: Centre for Nanoscale Science, Department of Chemistry, The University of Liverpool, Liverpool, UK.
authors.forename: Zhenxin
authors.initials: Z
authors.lastname: Wang
authors.forename: Raphaël
authors.initials: R
authors.lastname: Lévy
authors.forename: David G
authors.initials: DG
authors.lastname: Fernig
authors.forename: Mathias
authors.initials: M
authors.lastname: Brust
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000235:genetics / Q000378:metabolism; D006046:Gold / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D008969:Molecular Sequence Data; D049329:Nanostructures; D010455:Peptides / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D040081:Protein Array Analysis; D012834:Silver / Q000737:chemistry
chemical_list: D008024:Ligands; D010455:Peptides; D012834:Silver; D006046:Gold; D004247:DNA