What targets have knockouts revealed in asthma?
There have been numerous studies of mice rendered genetically deficient of various genes in the context of allergic inflammatory airway disease. These studies have provided invaluable information about basic immune processes, but have also been considered to be useful in predicting novel pharmacological targets. In this review, the effect of a wide range of individual knockouts (KO) on the development of asthma-like pathologies in mice is compiled and considered. How the results of these studies compare with effects of agents that interfere with the function of each gene product, where known, is also described. Finally, a personal view of the utility of these studies in drug development is presented.
Moffatt
James D
JD
The Sackler Institute of Pulmonary Pharmacology, 5th Floor Hodgkin Building, Guy's Campus, King's College London, London SE1 1UL, UK. james.moffatt@kcl.ac.uk
D000818:Animals; D001249:Asthma / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000503:physiopathology; D002448:Cell Adhesion; D016207:Cytokines / Q000502:physiology; D006801:Humans; D007249:Inflammation; D008024:Ligands; D051379:Mice; D018345:Mice, Knockout; D010447:Peptide Hydrolases / Q000378:metabolism; D011480:Protease Inhibitors / Q000494:pharmacology; D018121:Receptors, Cytokine / Q000502:physiology; D015398:Signal Transduction
D016207:Cytokines; D008024:Ligands; D011480:Protease Inhibitors; D018121:Receptors, Cytokine; D010447:Peptide Hydrolases