title: Efficacy of moxidectin injectable and pour-on formulations in a pilot control program against bovine hypodermosis in Southern Italy.
abstract: Bovine hypodermosis is a myiasis caused by Hypoderma bovis and Hypoderma lineatum (Diptera, Oestridae) larvae, which has a severe economic impact on the livestock industry. Though myiasis is widespread throughout Italy, no nationwide eradication program has ever been planned, unlike in other European Countries. With a view to setting up a national control program, a pilot study was carried out in Southern Italy on 9939 cattle bred in an area with a high prevalence of cattle hypodermosis, using moxidectin 0.5% pour-on (Cydectin, Fort Dodge) and 1% injectable (Cydectin, Fort Dodge) formulations. At the recommended dosage, moxidectin displayed efficacy levels of 99.9% in the pour-on and 100% in the injectable formulation, whereas the microdose (1 mg per head regardless of body weight) was less effective (65.7%). This trial contributed to a significant reduction in infestation rates in the study area and represented the first step through which a national program for eradicating warble fly infestation in Italy.
authors.affiliation: Department of Animal Health and Welfare, Faculty of Veterinary Medicine, Strada Provinciale per Casamassima Km. 3, 70010 Valenzano, Bari, Italy. d.otranto@veterinaria.uniba.it
authors.forename: Domenico
authors.initials: D
authors.lastname: Otranto
authors.forename: Riccardo P
authors.initials: RP
authors.lastname: Lia
authors.forename: Alessandro
authors.initials: A
authors.lastname: Agostini
authors.forename: Donato
authors.initials: D
authors.lastname: Traversa
authors.forename: Piermarino
authors.initials: P
authors.lastname: Milillo
authors.forename: Gioia
authors.initials: G
authors.lastname: Capelli
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology; D004175:Diptera; D004334:Drug Administration Schedule; D007279:Injections, Subcutaneous / Q000662:veterinary; D007306:Insecticides / Q000008:administration & dosage*; D007558:Italy / Q000453:epidemiology; D018942:Macrolides / Q000008:administration & dosage*; D009198:Myiasis / Q000188:drug therapy / Q000662:veterinary*; D010865:Pilot Projects; D016896:Treatment Outcome
chemical_list: D007306:Insecticides; D018942:Macrolides; C027837:moxidectin