Androgen metabolism in invertebrates and its modulation by xenoandrogens: a comparative study.
Marisa cornuarietis (Mollusc), Hyalella azteca (Crustacean), and Paracentrotus lividus (Echinoderm) demonstrated the ability to metabolize androgens through different pathways catalyzed by 5alpha-reductases (5alpha-R), hydroxysteroid dehydrogenases (HSD), hydroxylases, sulfotransferases (SULT), and fatty-acid acyl-CoA acyltransferases (ATAT). Interspecies differences and tissue-specific distribution of those enzymatic activities were observed. Xenobiotics, such as triphenyltin, tributyltin, and fenarimol, interfered with some of the pathways studied, namely, testosterone sulfation, testosterone esterification, and 5alpha-R activity. The work evidenced different sensitivity of those pathways to androgenic compounds, together with interphyla differences in androgen metabolism.
Janer
G
G
Department of Environmental Chemistry, IIQAB-CSIC, Barcelona, Spain.
Leblanc
G A
GA
Porte
C
C
D000728:Androgens / Q000378:metabolism*; D000818:Animals; D003445:Crustacea / Q000378:metabolism*; D004447:Echinodermata / Q000378:metabolism*; D008974:Mollusca / Q000378:metabolism*; D013045:Species Specificity; D015262:Xenobiotics / Q000378:metabolism*
D000728:Androgens; D015262:Xenobiotics