[Effect of polymer concentration on rheological properties of Carbopol 980 hydrogels containing trimecainium chloride].
Rheological properties exert influence on the manufacturing processes, stability and usability of a dosage form as well as the biological availability of an active ingredient. The present paper examines the effect of Carbopol 980 concentration on rheological properties of hydrogels with and without trimecainium chloride for a period of 2, 7, and 14 days after their preparation. On the basis of an evaluation of the changes in structural viscosity in dependence on the period of measurement, it has been concluded that for formulation of trimecainium chloride to a dermal dosage form, Carbopol 980 concentrations of 0.5 and 1.2 % are suitable.
Subová
M
M
Farmaceutická fakulta Univerzity Komenského v Bratislave, Katedra galenickej farmácie. margareta@centrum.sk
Vitková
Z
Z
Cirbusová
E
E
Erös
I
I
Kónya
M
M
D000180:Acrylic Resins / Q000737:chemistry*; D000779:Anesthetics, Local; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D020100:Hydrogels / Q000737:chemistry*; D012212:Rheology; D014288:Trimecaine
D000180:Acrylic Resins; D000779:Anesthetics, Local; D020100:Hydrogels; C479038:carbomer; D014288:Trimecaine