CYP17 genotype predicts serum hormone levels among pre-menopausal women.
BACKGROUND
CYP17, which encodes cytochrome P450c17alpha, mediates both steroid 17alpha-hydroxylase and 17,20-lyase activities, and is essential for the production of glucocorticoids and sex steroids. There is evidence that a common polymorphism in CYP17 (T27C) is associated with estrogen levels, making it a potential marker of disease risk.


METHODS
This is the first study to examine the relationship between CYP17 and estradiol (E2) using serum sampled exclusively from the early follicular phase of the menstrual cycle. We assessed the relationship between CYP17 and serum hormone levels, menstrual cycle length, bleed length, and age at menarche in 164 pre-menopausal women.


RESULTS
Among women with body mass index (BMI) < or =25 kg/m2, those with the TC and CC genotypes had 19 and 42% higher E2 (P for trend 0.007) and 14 and 30% higher dehydroepiandrosterone sulphate respectively (P for trend 0.10) than women with the TT genotype. Androstenedione levels did not differ between genotypes. Among women with BMI >25 kg/m2, hormone levels did not differ by genotype. Women with the C allele were also more likely to have menstrual cycle lengths <27 days [odds ratio (OR) for TC=2.36, 95% confidence interval (CI)=1.24-4.52; OR for CC=5.59, 95% CI=1.53-20.43 compared to TT]. CYP17 genotype was not associated with menstrual bleed length or age at menarche.


CONCLUSIONS
The CYP17 T27C polymorphism may be a marker of endocrine function.
Small
Chanley M
CM
Department of Epidemiology, Emory University, Atlanta, Georgia and American Cancer Society, Atlanta, Georgia 30322, USA. csmall@sph.emory.edu
Marcus
Michele
M
Sherman
Stephanie L
SL
Sullivan
Amy K
AK
Manatunga
Amita K
AK
Feigelson
Heather Spencer
HS
D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D005260:Female; D005498:Follicular Phase / Q000097:blood / Q000235:genetics; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008572:Menarche / Q000235:genetics; D008598:Menstruation / Q000097:blood / Q000235:genetics; D008875:Middle Aged; D011237:Predictive Value of Tests; D017697:Premenopause / Q000097:blood* / Q000235:genetics*; D013254:Steroid 17-alpha-Hydroxylase / Q000097:blood* / Q000235:genetics*
D005819:Genetic Markers; D013254:Steroid 17-alpha-Hydroxylase