[Compensatory adjustment of hemopoietic stem cell pool of CBA mice after acute intake of 90Sr].
It was investigated the functional status of stem cell pool (CFUs) of bone marrow, spleen and peripheral blood in mice (CBA) in early (1-30 days) and late (180-360 days) period after acute intake of 90Sr (29.6 kBq/g). Cumulative dose in red bone marrow due to incorporated 90Sr was 0.98-87.7 Gy. The kinetics, proliferative and differentiative potential of stem hemopoietic cells (CFUs) and productivity of hemopoietic tissues were significantly influenced by dose rate, absorbed dose and degree of suppresssion of bone marrow functions. The obtained results indicated that the sarcomogenous doses of 90Sr (29.6 kBq/g) resulted in realization of compensatory reactions in hemopoietic stem cell pool to support the life ability of irradiated animals: higher proliferative potential of CFUs and its repopulation, redistribution of cell subpopulations during differentiation and activation of spleens hemopoiesis.
Shibkova
D Z
DZ
Efimova
N V
NV
Toletykh
E I
EI
Andreeva
O G
OG
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D001854:Bone Marrow Cells / Q000166:cytology / Q000528:radiation effects; D002455:Cell Division / Q000528:radiation effects; D003114:Colony-Forming Units Assay; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006410:Hematopoiesis / Q000528:radiation effects; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental; D013154:Spleen / Q000166:cytology / Q000528:radiation effects; D013326:Strontium Radioisotopes / Q000008:administration & dosage* / Q000494:pharmacology; D013997:Time Factors
D013326:Strontium Radioisotopes