title: [Primary effect of submandibular salivary gland transfer in preventing radiation-induced xerostomia of nasopharyngeal carcinoma].
abstract: OBJECTIVE
  Xerostomia, an ubiquitous sequelae in nasopharyngeal carcinoma (NPC) patients after radiotherapy, seriously affects life quality of the patients. This study was to investigate clinical value of submandibular salivary gland transfer in preventing radiation-induced xerostomia of NPC patients.
  
  
  METHODS
  A total of 70 eligible patients with NPC were recruited, and divided into test group (36 patients) and control group (34 patients). In test group, the submandibular glands were transferred to the submental spaces before conventional radiotherapy. The submental spaces were shielded during radiotherapy. Oral cavity mucous membrane reaction during radiotherapy, submandibular gland function and salivary fluid before and after radiotherapy, and questionnaire of xerostomia 3 months after radiotherapy were compared between test group and control group.
  
  
  RESULTS
  Acute oral cavity mucous membrane reaction was severer in control group than in test group; the incidence of stage III reaction was significantly higher in control group than in test group ( 8/34 vs. 3/36, P = 0.007). Three months after radiotherapy, trapping and excretion functions of the transferred submandibular glands were significantly better than those of the untransferred submandibular glands in test group (P = 0.001 and P = 0.000); trapping and excretion functions of the submandibular glands were significantly better in test group than in control group (P = 0.004 and P = 0.000). The mean weight of salivary fluid after radiotherapy was heavier in test group than in control group (1.41 g vs. 0.71 g). Incidence of moderate to severe degree of xerostomia was significantly higher in test group than in control group (76.5% vs. 13.9%, P = 0.000).
  
  
  CONCLUSIONS
  Submandibular gland transfer may be used to prevent radiation-induced xerostomia of NPC patients, and may improve life quality of the patients.
authors.affiliation: Department of Head and Neck Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P.R.China. liuxuekui@sohu.com
authors.forename: Xue-Kui
authors.initials: XK
authors.lastname: Liu
authors.forename: Zong-Yuan
authors.initials: ZY
authors.lastname: Zeng
authors.forename: Ming-Huang
authors.initials: MH
authors.lastname: Hong
authors.forename: Nian-Ji
authors.initials: NJ
authors.lastname: Cui
authors.forename: Yong
authors.initials: Y
authors.lastname: Su
authors.forename: Hai-Qiang
authors.initials: HQ
authors.lastname: Mai
authors.forename: Fu-Jin
authors.initials: FJ
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D009367:Neoplasm Staging; D010315:Particle Accelerators; D011446:Prospective Studies; D011788:Quality of Life; D011882:Radiotherapy, High-Energy / Q000009:adverse effects; D012463:Saliva / Q000378:metabolism; D013363:Submandibular Gland / Q000378:metabolism / Q000601:surgery*; D011795:Surveys and Questionnaires; D014987:Xerostomia / Q000209:etiology / Q000517:prevention & control*