Developmental neurobiology and clinical disorders: lost in translation?
Advances in defining mechanisms of cortical development have been paralleled in recent years by an intense interest in translating these findings into greater insight of both childhood- and adult-onset cognitive and mental health disorders of developmental etiology. Successful integration of basic and clinical findings have been applied to monogenic disorders. The greater challenge lies in studying cortical development in the context of gene x environment interactions, which underlie the pathogenesis of the most common neurodevelopmental disorders. This can occur through an improved delineation of pathophysiological characteristics unique to specific complex disorders and the application of this information to the refinement of the most relevant model systems.
Levitt
Pat
P
Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee 37203, USA. pat.levitt@vanderbilt.edu
D000818:Animals; D001921:Brain / Q000196:embryology / Q000473:pathology; D002648:Child; D002658:Developmental Disabilities / Q000209:etiology*; D004781:Environmental Exposure / Q000009:adverse effects; D006801:Humans