title: Increased fasting plasma insulin concentrations are associated with the severity of angiographic coronary artery disease.
abstract: Fasting plasma insulin concentrations were obtained in 82 patients (51 men and 31 women), mean age 60 +/- 11 years, with a body mass index >25 kg/m(2) who had coronary angiography because of suspected symptomatic coronary artery disease (CAD). Obstructive CAD was diagnosed if there was >50% obstruction of > or =1 vessel. Of 82 patients, 37 (45%) had left main or 3-vessel CAD, 22 (27%) had 2-vessel CAD, 9 (11%) had 1-vessel CAD, and 14 (17%) had no obstructive CAD. Among the 4 groups, there was no significant difference in gender, age, dyslipidemia, and smoking. Hypertension (p = 0.0003), diabetes mellitus (p = 0.035), and increased fasting plasma insulin concentration (p < 0.0001) were significantly associated with the severity of CAD. Stepwise ordinal logistic regression analysis identified increased fasting plasma insulin concentrations in these obese subjects as a significant independent risk factor for the severity of angiographic CAD (p < 0.0001).
authors.affiliation: Department of Medicine, Cardiology Division, Westchester Medical Center/New York Medical College, Valhalla, NY 10595, USA.
authors.forename: Rishi
authors.initials: R
authors.lastname: Sukhija
authors.forename: Wilbert S
authors.initials: WS
authors.lastname: Aronow
authors.forename: Devraj
authors.initials: D
authors.lastname: Nayak
authors.forename: Chul
authors.initials: C
authors.lastname: Ahn
authors.forename: Melvin B
authors.initials: MB
authors.lastname: Weiss
mesh_terms: D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood* / Q000000981:diagnostic imaging; D048909:Diabetes Complications; D005215:Fasting; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D006973:Hypertension / Q000150:complications; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D012907:Smoking / Q000009:adverse effects
chemical_list: D007328:Insulin