title: Preeclampsia: a renal perspective.
abstract: Preeclampsia is a syndrome that affects 5% of all pregnancies, producing substantial maternal and perinatal morbidity and mortality. The aim of this review is to summarize our current understanding of the pathogenesis of preeclampsia with special emphasis on the recent discovery that circulating anti-angiogenic proteins of placental origin may play an important role in the pathogenesis of proteinuria and hypertension of preeclampsia.
authors.affiliation: Renal Division and Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA. sananth@bidmc.harvard.edu
authors.forename: S Ananth
authors.initials: SA
authors.lastname: Karumanchi
authors.forename: Sharon E
authors.initials: SE
authors.lastname: Maynard
authors.forename: Isaac E
authors.initials: IE
authors.lastname: Stillman
authors.forename: Franklin H
authors.initials: FH
authors.lastname: Epstein
authors.forename: Vikas P
authors.initials: VP
authors.lastname: Sukhatme
mesh_terms: D005260:Female; D017359:HELLP Syndrome / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007668:Kidney / Q000473:pathology; D010920:Placenta / Q000502:physiology; D011225:Pre-Eclampsia / Q000150:complications / Q000209:etiology*; D011247:Pregnancy; D011507:Proteinuria / Q000209:etiology; D012307:Risk Factors; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology
chemical_list: D042461:Vascular Endothelial Growth Factor A