title: Recognition of CG inversions in DNA triple helices by methylated 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues.
abstract: Substituted 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues have been synthesised from 5-alkynyl-uridine derivatives, incorporated into triplex forming oligonucleotides (TFOs) and found to selectively bind CG inversions with enhanced affinity compared to T.
authors.affiliation: School of Chemistry, University of Southampton, Highfield, Southampton, UK SO17 1BJ.
authors.forename: Rohan T
authors.initials: RT
authors.lastname: Ranasinghe
authors.forename: David A
authors.initials: DA
authors.lastname: Rusling
authors.forename: Vicki E C
authors.initials: VE
authors.lastname: Powers
authors.forename: Keith R
authors.initials: KR
authors.lastname: Fox
authors.forename: Tom
authors.initials: T
authors.lastname: Brown
mesh_terms: D020029:Base Pairing; D003596:Cytosine / Q000032:analysis* / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D006147:Guanine / Q000032:analysis* / Q000737:chemistry; D006860:Hydrogen Bonding; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry; D011744:Pyrimidinones / Q000138:chemical synthesis / Q000737:chemistry*; D013941:Thymine / Q000032:analysis / Q000737:chemistry
chemical_list: D009705:Nucleosides; D009841:Oligonucleotides; D011744:Pyrimidinones; C051802:triplex DNA; D006147:Guanine; D003596:Cytosine; D004247:DNA; D013941:Thymine