Chemopreventive and therapeutic effects of curcumin.
Chemoprevention is a promising anti-cancer approach with reduced secondary effects in comparison to classical chemotherapy. Curcumin, one of the most studied chemopreventive agents, is a natural compound extracted from Curcuma longa L. that allows suppression, retardation or inversion of carcinogenesis. Curcumin is also described as an anti-tumoral, anti-oxidant and anti-inflammatory agent capable of inducing apoptosis in numerous cellular systems. In this review, we describe both properties and mode of action of curcumin on carcinogenesis, gene expression mechanisms and drug metabolism.
Duvoix
Annelyse
A
Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hôpital Kirchberg, 9, rue Edward Steichen, L-2540 Luxembourg, Luxembourg.
Blasius
Romain
R
Delhalle
Sylvie
S
Schnekenburger
Michaël
M
Morceau
Franck
F
Henry
Estelle
E
Dicato
Mario
M
Diederich
Marc
M
D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D018890:Chemoprevention; D003474:Curcumin / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004789:Enzyme Activation; D006801:Humans; D016328:NF-kappa B / Q000037:antagonists & inhibitors; D009369:Neoplasms / Q000517:prevention & control*; D014157:Transcription Factors / Q000037:antagonists & inhibitors
D000970:Antineoplastic Agents; D016328:NF-kappa B; D014157:Transcription Factors; D003577:Cytochrome P-450 Enzyme System; D003474:Curcumin