The peptide route to multifunctional gold nanoparticles.
Extremely stable, peptide-capped gold nanoparticles with two different biomolecular recognition motifs expressed on their surface have been prepared, and their specific and selective binding to artificial, DNA-modified target particles and to DNA and protein microarrays has been demonstrated. Stabilization and biofunctionalization has been achieved in a single preparative step starting with citrate-stabilized gold hydrosols and a derivatization cocktail of peptide-capping ligands, which carry the functionalities of choice.
Wang
Zhenxin
Z
Centre for Nanoscale Science, Department of Chemistry, The University of Liverpool, Liverpool, UK.
Lévy
Raphaël
R
Fernig
David G
DG
Brust
Mathias
M
D001483:Base Sequence; D004247:DNA / Q000235:genetics / Q000378:metabolism; D006046:Gold / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D008969:Molecular Sequence Data; D049329:Nanostructures; D010455:Peptides / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D040081:Protein Array Analysis; D012834:Silver / Q000737:chemistry
D008024:Ligands; D010455:Peptides; D012834:Silver; D006046:Gold; D004247:DNA