title: The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.
authors.affiliation: Victorian College of Pharmacy, Monash University (Parkville Campus), 381 Royal Parade, Parkville Victoria, 3052, Australia. david.manallack@vcp.monash.edu.au
authors.forename: David T
authors.initials: DT
authors.lastname: Manallack
authors.forename: Richard A
authors.initials: RA
authors.lastname: Hughes
authors.forename: Philip E
authors.initials: PE
authors.lastname: Thompson
mesh_terms: D000818:Animals; D001665:Binding Sites; D018360:Crystallography, X-Ray; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D010726:Phosphodiesterase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D021281:Quantitative Structure-Activity Relationship; D014970:Xanthines / Q000737:chemistry
chemical_list: D010726:Phosphodiesterase Inhibitors; D014970:Xanthines; D000242:Cyclic AMP; D006152:Cyclic GMP