Insulin independence after living-donor distal pancreatectomy and islet allotransplantation.
Rising demand for islet transplantation will lead to severe donor shortage in the near future, especially in countries where cadaveric organ donation is scarce. We undertook a successful transplantation of living-donor islets for unstable diabetes. The recipient was a 27-year-old woman who had had brittle, insulin-dependent diabetes mellitus for 12 years. The donor, who was a healthy 56-year-old woman and mother of the recipient, underwent a distal pancreatectomy. After isolation, 408 114 islet equivalents were transplanted immediately. The transplants functioned immediately and the recipient became insulin-independent 22 days after the operation. The donor had no complications and both women showed healthy glucose tolerance. Transplantation of living-donor islets from the distal pancreas can be sufficient to reverse brittle diabetes.
Matsumoto
Shinichi
S
Kyoto University Hospital Transplantation Unit, Kyoto Japan. shinichi@kuhp.kyoto-u.ac.jp
Okitsu
Teru
T
Iwanaga
Yasuhiro
Y
Noguchi
Hirofumi
H
Nagata
Hideo
H
Yonekawa
Yukihide
Y
Yamada
Yuichiro
Y
Fukuda
Kazuhito
K
Tsukiyama
Katsushi
K
Suzuki
Haruhiko
H
Kawasaki
Yukiko
Y
Shimodaira
Makiko
M
Matsuoka
Keiko
K
Shibata
Toshiya
T
Kasai
Yasunari
Y
Maekawa
Taira
T
Shapiro
James
J
Tanaka
Koichi
K
D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000601:surgery*; D005260:Female; D006801:Humans; D016381:Islets of Langerhans Transplantation; D019520:Living Donors; D008875:Middle Aged; D010180:Pancreatectomy / Q000379:methods*; D010195:Pancreatitis / Q000150:complications; D020858:Tissue and Organ Harvesting / Q000379:methods*