title: Safety of varying dosages of 7-valent pneumococcal protein conjugate vaccine in seniors previously vaccinated with 23-valent pneumococcal polysaccharide vaccine.
abstract: In a phase I/II dose escalation study, varying volumes (0.1 ml, 0.5 ml, 1.0 ml and 2.0 ml) of 7-valent pneumococcal conjugate vaccine (PCV) (Prevnar or 0.5 ml of 23-valent pneumococcal polysaccharide vaccine (PPV) were administered to 220 adults 70 through 79 years of age previously vaccinated with 0.5 ml PPV at age 65 years or above and at least 5 years previously. Fever was uncommon and did not vary by study group. The rate of local reactions increased with higher volumes of PCV and the rate following 2.0 ml of PCV was comparable to that following 0.5 ml PPV.
authors.affiliation: Center for Health Studies, Group Health Cooperative, 1730 Minor Ave, Ste 1600, Seattle, WA 98101, USA. jackson.l@ghc.org
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Jackson
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Neuzil
authors.forename: Cynthia G
authors.initials: CG
authors.lastname: Whitney
authors.forename: Patty
authors.initials: P
authors.lastname: Starkovich
authors.forename: Maya
authors.initials: M
authors.lastname: Dunstan
authors.forename: Onchee
authors.initials: O
authors.lastname: Yu
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Nelson
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Feikin
authors.forename: David K
authors.initials: DK
authors.lastname: Shay
authors.forename: James
authors.initials: J
authors.lastname: Baggs
authors.forename: Barb
authors.initials: B
authors.lastname: Carste
authors.forename: Moon H
authors.initials: MH
authors.lastname: Nahm
authors.forename: George
authors.initials: G
authors.lastname: Carlone
mesh_terms: D000368:Aged; D005260:Female; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D008297:Male; D022401:Meningococcal Vaccines / Q000008:administration & dosage* / Q000009:adverse effects*; D011008:Pneumococcal Infections / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage* / Q000009:adverse effects*
chemical_list: C414006:23-valent pneumococcal capsular polysaccharide vaccine; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022401:Meningococcal Vaccines; D022242:Pneumococcal Vaccines