Human CD8+ T cells specific for influenza A virus M1 display broad expression of maturation-associated phenotypic markers and chemokine receptors.
To define the role of memory T cells in a non-persistent viral infection, we have delineated the phenotype of memory CD8+ T cells specific for influenza A virus (FluA; matrix protein M158-66) based on the expression of several memory/effector lineage markers and relevant chemokine receptors. We found a majority of FluA-specific CD8+ T cells expressed CD27 and CD28, and variably expressed CD45RA, CD62L, CD94 and granzyme A. A majority of FluA-specific CD8+ T cells expressed high levels of CXCR3, and moderate levels of CCR5 and CXCR4, whereas a limited proportion expressed CCR7, CCR6 and CXCR5. A phenotypic profile based on these observations showed that there are both immature and mature memory CD8+ T cells specific for FluA.
Hoji
Aki
A
Department of Infectious Diseases and Microbiology, Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Rinaldo
Charles R
CR
D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology; D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology; D016130:Immunophenotyping; D009980:Influenza A virus / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000378:metabolism; D019707:Receptors, Chemokine / Q000378:metabolism*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D015703:Antigens, CD; D018984:Epitopes, T-Lymphocyte; D016693:Receptors, Antigen, T-Cell, alpha-beta; D019707:Receptors, Chemokine