Invasion and metastasis markers in cancers.
Over 90% of all adults human cancers are of epithelial origin comprising mainly of skin and aero-digestive tract cancers. A significant proportion of our discipline's workload consists of management of these cancers. This review article is to provide clinicians with a summary of the current research findings in invasion and metastasis of epithelial cancers and the translation of some of this information to clinical use particularly related to skin and head and neck cancers (HNSCC). Metastasis is the leading cause of death in cancer patients. Although surgical resection of isolated metastases is beneficial for some patients, the overall efficacy of surgery, chemotherapy or radiotherapy is limited. Clearly, with today's advances in surgery a majority of these primary cancers are resectable and a cure attainable if surgeons could control or inhibit metastasis.
Chin
David
D
Department of Plastic and Reconstructive Surgery, Princess Alexandra Hospital, Brisbane, Queensland, Australia. davidC@qimr.edu.au
Boyle
Glen M
GM
Kane
Anthony J
AJ
Theile
David R
DR
Hayward
Nicholas K
NK
Parson
Peter G
PG
Coman
William B
WB
D000328:Adult; D043925:Angiogenesis Inducing Agents / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis*; D015815:Cell Adhesion Molecules / Q000032:analysis; D006258:Head and Neck Neoplasms / Q000378:metabolism; D006801:Humans; D009361:Neoplasm Invasiveness / Q000175:diagnosis*; D009362:Neoplasm Metastasis / Q000175:diagnosis*; D010447:Peptide Hydrolases / Q000378:metabolism; D012878:Skin Neoplasms / Q000378:metabolism
D043925:Angiogenesis Inducing Agents; D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; D010447:Peptide Hydrolases