title: The clinical application of proteomics.
abstract: BACKGROUND
  Proteomics is defined as a scientific approach used to elucidate all protein species within a cell or tissue, and many researchers are taking advantage of proteomic technology to elucidate protein changes between healthy and diseased states.
  
  
  METHODS
  The application of proteomic techniques and strategies to the field of medicine is slowly transforming the way biomarker discovery is conducted. However, the complexity of serum is the source of both its promise to clinical applications and its challenge to proteomic analysis. Like any new technology when it is first introduced, proteomics has been touted with much hope and promise.
  
  
  CONCLUSIONS
  We provide a review of the clinical application of proteomics with the emphasis on current practical issues and challenges facing proteomic research.
authors.affiliation: Department of Pathology, Clinical Chemistry Division, Johns Hopkins Medical Institutions, 600 North Wolfe Street/Meyer B-121, Baltimore, MD 21287-7065, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Colantonio
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Chan
mesh_terms: D006801:Humans; D008511:Medicine / Q000379:methods* / Q000639:trends; D040901:Proteomics / Q000379:methods* / Q000639:trends