title: Massive brain injury enhances lung damage in an isolated lung model of ventilator-induced lung injury.
abstract: OBJECTIVE
  To assess the influence of massive brain injury on pulmonary susceptibility to injury attending subsequent mechanical or ischemia/reperfusion stress.
  
  
  METHODS
  Prospective experimental study.
  
  
  METHODS
  Animal research laboratory.
  
  
  METHODS
  Twenty-four anesthetized New Zealand White rabbits randomized to control (n = 12) or induced brain injury (n = 12) group.
  
  
  METHODS
  After randomization, brain injury was induced by inflation of an intracranial balloon-tipped catheter, and animals were ventilated with a tidal volume of 10 mL/kg and zero end-expiratory pressure for 120 mins. Following heart-lung block extraction, isolated and perfused lungs were subjected to injurious ventilation with peak airway pressure 30 cm H2O and positive end-expiratory pressure 5 cm H2O for 30 mins.
  
  
  RESULTS
  No difference was observed between groups in gas exchange, lung mechanics, or hemodynamics during the 2-hr in vivo period following induction of brain injury. However, after 30 mins of ex vivo injurious mechanical ventilation, lungs from the brain injury group showed greater change in ultrafiltration coefficient, weight gain, and alveolar hemorrhage (all p < .05).
  
  
  CONCLUSIONS
  Massive brain injury might increase lung vulnerability to subsequent injurious mechanical or ischemia-reperfusion insults, thereby increasing the risk of clinical posttransplant graft failure.
authors.affiliation: Hospital de Sabadell, Institut Universitari Parc Taulí, Universitat Autònoma de Barcelona, Spain.
authors.forename: Josefina
authors.initials: J
authors.lastname: López-Aguilar
authors.forename: Ana
authors.initials: A
authors.lastname: Villagrá
authors.forename: Francesca
authors.initials: F
authors.lastname: Bernabé
authors.forename: Gastón
authors.initials: G
authors.lastname: Murias
authors.forename: Enrique
authors.initials: E
authors.lastname: Piacentini
authors.forename: Jordi
authors.initials: J
authors.lastname: Real
authors.forename: Pilar
authors.initials: P
authors.lastname: Fernández-Segoviano
authors.forename: Pablo V
authors.initials: PV
authors.lastname: Romero
authors.forename: John R
authors.initials: JR
authors.lastname: Hotchkiss
authors.forename: Lluis
authors.initials: L
authors.lastname: Blanch
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000150:complications*; D004195:Disease Models, Animal; D011175:Positive-Pressure Respiration; D011659:Pulmonary Gas Exchange; D011817:Rabbits; D012121:Respiration, Artificial / Q000009:adverse effects*; D012128:Respiratory Distress Syndrome / Q000209:etiology* / Q000473:pathology