[The blood oxygen-transport system and oxygen tissue balance in patients with bronchial asthma (BA) concurrent with carbohydrate metabolic disturbances].
Examining the parameters of the blood oxygen-transport system and oxygen tissue balance in 71 patients with bronchial asthma (BA) and in 60 patients with BA concurrent with varying carbohydrate metabolic disturbances (CMDs) revealed differences in oxygen transport. In asthmatic patients without CMDs, the pattern of changes in oxygen balance permitted identification of arteriohypoxemic hypoxia. The high frequency of factors (alkalosis, hypocapnia) that enhance hemoglobin affinity for oxygen, which are compensated for by the increase in 2,3-DPH, as well as hypoxia of peripheral shunting are the specific features of impaired oxygen balance in asthmatic patients with concomitant CMDs that predispose to the development and progression of pulmonary hypertension and cor pulmonale which cause early disability. The determination of the leading link in impaired oxygen transport individualizes treatment approaches and provides evidence for a need for earlier use of metabolic and antihypoxic agents in asthmatic patients with CMDs.
Liverko
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D000136:Acid-Base Equilibrium / Q000502:physiology; D000328:Adult; D001249:Asthma / Q000150:complications / Q000378:metabolism*; D015824:Blood-Air Barrier / Q000378:metabolism*; D018981:Congenital Disorders of Glycosylation / Q000150:complications / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D000860:Hypoxia / Q000097:blood / Q000209:etiology; D010100:Oxygen / Q000378:metabolism*
D006454:Hemoglobins; D010100:Oxygen