Glutathione S-transferases activity in patients with colorectal cancer.
OBJECTIVE
The glutathione S-transferases (GSTs) play a critical role in protecting the colorectal mucosa. We investigated the efficacy of using the GSTs activity of plasma as a biomarker of risk for colorectal cancer.


METHODS
GSTs activity was measured in the plasma of control individuals (n=39) and in the plasma, tumor tissue and normal tissue adjacent to a tumor of patients with colorectal cancer taken at colonoscopy (n=60).


RESULTS
Mean GSTs activity was significantly (P< 0.01) higher in tumors (242+/- 45 nmol/min mg protein) as compared to normal tissues adjacent to a tumor (84+/- 49 nmol/min mg protein). A significant correlation between normal tissues adjacent to a tumor GSTs with those in malignant tissues was observed (r=0.61). Plasma GSTs activity was significantly (P<0.0001) higher in colorectal cancer patients (164+/-11 nmol/min mL) than those obtained from normal individuals (92+/- 23 nmol/min mL).


CONCLUSIONS
GSTs measurement may be useful as a colorectal cancer marker in colorectal cancer, and biopsies obtained at colonoscopy can be used to measure tumor markers.
Nomani
Hamid
H
Biochemistry Department, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Ghobadloo
Shahrokh Mohammadzadeh
SM
Yaghmaei
Bahram
B
Rezvanie
Nayeb Ali
NA
Yaghmaei
Kaveh
K
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D001706:Biopsy; D003106:Colon / Q000201:enzymology; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000201:enzymology*; D005260:Female; D005982:Glutathione Transferase / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012306:Risk
D014408:Biomarkers, Tumor; D005982:Glutathione Transferase