Recurrence of primary hepatic carcinoid tumor in the remnant liver 13 yr after resection.
We report here a case of primary hepatic carcinoid tumor (PHCT) recurring in the remnant liver 13 yr and 10 mo after first resection. A 70-yr-old man developed four hypervascular tumors in the liver in December 2003. He had undergone curative left-lobe hepatectomy for PHCT in February 1990. Histopathological examination of the tumor biopsy specimen showed that the tumor was composed of uniform round-to-oval cells with solid arrangement and the tumor cells stained positive for chromogranin A, synaptophysin, and neuron-specific enolase. We diagnosed this case as an intrahepatic metastasis of PHCT with a long latency period, based on the fact that no primary site of carcinoid tumor could be found despite intensive examination and the immunohistochemical findings of the resected tumors were essentially same as those of PHCT in 1990. Although PHCT is reported to have a more favorable prognosis than other hepatic cancer or metastatic carcinoid tumor in the liver, long-term observation is recommended.
Nishimori
Hiroyuki
H
Center for Gastroenterology, Teine Keijinkai Hospital, 1-12-1-40 Maeda, Teine-ku, Sapporo, 006-8555, Japan. nisimori.tdr@keijinkai.or.jp
Tsuji
Kunihiko
K
Miyamoto
Noriyuki
N
Sakurai
Yasuo
Y
Mitsui
Shinya
S
Kang
Jong-Hon
JH
Yoshida
Masafumi
M
Nomura
Masashi
M
Fuminori
Itokawa
I
Ishiwatari
Hirotoshi
H
Matsunaga
Takahiro
T
Osanai
Manabu
M
Katanuma
Akio
A
Takahashi
Kuniyuki
K
Anbo
Yoshinori
Y
Masuda
Tomoshige
T
Kashimura
Nobuichi
N
Shinohara
Toshiya
T
Maguchi
Hiroyuki
H
D000368:Aged; D002276:Carcinoid Tumor / Q000473:pathology* / Q000601:surgery*; D006498:Hepatectomy; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000473:pathology* / Q000601:surgery*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000601:surgery*; D013997:Time Factors