Structure and biological activity of heparinoid.
Heparin is a biogenic anionic charged sulfated polysaccharide that has a range of desired activities including inhibition of tumor metastasis and inhibition of restenosis. However, its clinical use is limited to treating blood-clotting disorders. Anionic macromolecules called heparinoids have been investigated with the objective of developing heparin-like molecules with reduced anti-coagulant activity and selective anti-metastasis and anti-restenosis activity. This mini-review summarizes the synthesis and biological activity of the main synthetic heparinoids reported in the past three decades.
Kumar
Neeraj
N
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, S.A.S. Nagar 060-062, India.
Bentolila
A
A
Domb
A J
AJ
D000596:Amino Acids / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000925:Anticoagulants / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D023903:Coronary Restenosis / Q000188:drug therapy / Q000517:prevention & control; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D005346:Fibroblast Growth Factors / Q000378:metabolism; D005966:Glucuronidase / Q000037:antagonists & inhibitors; D006493:Heparin / Q000737:chemistry / Q000494:pharmacology; D006496:Heparinoids / Q000737:chemistry / Q000494:pharmacology*; D006497:Heparan Sulfate / Q000378:metabolism; D006801:Humans; D009362:Neoplasm Metastasis / Q000188:drug therapy / Q000517:prevention & control; D000099175:Heparanase
D000596:Amino Acids; D000925:Anticoagulants; D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D005346:Fibroblast Growth Factors; D005966:Glucuronidase; D006493:Heparin; D006496:Heparinoids; D006497:Heparan Sulfate; D000099175:Heparanase