title: Successful treatment of rapidly progressive interstitial pneumonia with autologous peripheral blood stem cell transplantation in a patient with dermatomyositis.
abstract: Aggressive autoimmune diseases are often treated by intensive immunosuppressive treatment such as high-dose methylprednisolone and intravenous cyclophosphamide. Autologous hematopoietic stem cell transplantation can facilitate high-dose immunosuppressive therapy (HDIT), which is myeloablative. We describe a 54-year-old female patient with rapidly progressive and refractory interstitial pneumonia due to dermatomyositis, which was successfully treated with high-dose cyclophosphamide and autologous blood stem cell transplantation. Following transplantation, dyspnea disappeared, and arterial blood gas analysis and respiratory function test showed marked improvement. This improvement was confirmed by diminished interstitial shadows on chest X-ray and computed tomography scans. Eighteen months after transplantation, the patient is doing well without symptoms and signs of interstitial pneumonia.
authors.affiliation: Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Higashi-ku, Fukuoka, Japan.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Oryoji
authors.forename: Daisuke
authors.initials: D
authors.lastname: Himeji
authors.forename: Kouji
authors.initials: K
authors.lastname: Nagafuji
authors.forename: Takahiko
authors.initials: T
authors.lastname: Horiuchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tsukamoto
authors.forename: Hisashi
authors.initials: H
authors.lastname: Gondo
authors.forename: Mine
authors.initials: M
authors.lastname: Harada
mesh_terms: D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D003882:Dermatomyositis / Q000150:complications / Q000628:therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000628:therapy*; D016131:Lymphocyte Subsets / Q000473:pathology; D008875:Middle Aged; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D003520:Cyclophosphamide