title: Tissue distribution, elimination, and metabolism of dietary sodium [36Cl]chlorate in beef cattle.
abstract: Two steers (approximately 195 kg) were each dosed with 62.5 or 130.6 mg/kg body weight sodium [36Cl]chlorate for three consecutive days. All excreta were collected during the dosing and 8 h withdrawal periods. The apparent radiochlorine absorption was 62-68% of the total dose with the major excretory route being urine. Parent chlorate was 65-100% of the urinary radiochlorine; chloride was the only other radiochlorine species present. Similarly, residues in edible tissues were composed of chloride and chlorate with chloride being the major radiolabeled species present. Chlorate represented 28-57% of the total radioactive residues in skeletal muscle; in liver, kidney, and adipose tissues, chlorate ion represented a smaller percentage of the total residues. Chlorate residues in the low dose steer were 26 ppm in kidney, 14 ppm in skeletal muscle, 2.0 ppm in adipose tissue, and 0.7 ppm in liver. These data indicate that sodium chlorate may be a viable preharvest food safety tool for use by the cattle industry.
authors.affiliation: Biosciences Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, 1605 Albrecht Boulevard, Fargo, North Dakota 58105-5674, USA. smithd@fargo.ars.usda.gov
authors.forename: David J
authors.initials: DJ
authors.lastname: Smith
authors.forename: Robin C
authors.initials: RC
authors.lastname: Anderson
authors.forename: Dee A
authors.initials: DA
authors.lastname: Ellig
authors.forename: Gerald L
authors.initials: GL
authors.lastname: Larsen
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry; D000818:Animals; D002417:Cattle / Q000378:metabolism*; D002704:Chlorates / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism* / Q000493:pharmacokinetics* / Q000652:urine; D002712:Chlorides / Q000032:analysis / Q000652:urine; D002713:Chlorine / Q000652:urine; D004032:Diet; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D008297:Male; D018482:Muscle, Skeletal / Q000737:chemistry; D011868:Radioisotopes / Q000652:urine; D014018:Tissue Distribution
chemical_list: D002704:Chlorates; D002712:Chlorides; D011868:Radioisotopes; D002713:Chlorine; C032706:sodium chlorate