title: [Reactivation of persistent herpes virus infection as a factor of endogenous uveitis in children].
abstract: Two hundred and fifty-five children with endogenous uveitis, aged 2 months to 15 years, were examined. 73-93% of children were chronically infected by different viruses of the human herpes group; mycoplasmal past-infection was detected in only 13% of them and Chlamydia past-infection _ in 3.7% of them. Herpes simplex virus of type 1 reactivated reliably more often versus other types of Herpesviridae. Reactivation of cytomegalovirus infection prevailed in mothers who gave birth to children with intrauterine uveitis. A prolonged active replication of herpes virus was primarily observed in children with a Suppressed cell antiviral immunity component. Uveitis in such children was notable for a severe clinical course and trend towards often relapses.
authors.forename: G I
authors.initials: GI
authors.lastname: Krichevskaia
authors.forename: V O
authors.initials: VO
authors.lastname: Andzhelov
authors.forename: L A
authors.initials: LA
authors.lastname: Katargina
authors.forename: A V
authors.initials: AV
authors.lastname: Starikova
authors.forename: E V
authors.initials: EV
authors.lastname: Denisova
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Zvonarev
authors.forename: M N
authors.initials: MN
authors.lastname: Kuliakina
authors.forename: N G
authors.initials: NG
authors.lastname: Tsutskiridze
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003587:Cytomegalovirus / Q000254:growth & development / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000276:immunology / Q000635:transmission / Q000821:virology; D004279:DNA, Viral / Q000276:immunology; D005500:Follow-Up Studies; D006561:Herpes Simplex / Q000276:immunology / Q000635:transmission / Q000821:virology*; D018259:Herpesvirus 1, Human / Q000254:growth & development* / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008214:Lymphocytes / Q000276:immunology; D012008:Recurrence; D012720:Severity of Illness Index; D014605:Uveitis / Q000097:blood / Q000276:immunology / Q000821:virology*
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral