title: A pharmacological approach to enhancing the therapeutic index of corticosteroids in airway inflammatory disease.
abstract: Inhaled corticosteroids are highly effective agents for the treatment of asthma and chronic obstructive pulmonary disease. Although local delivery to the lung has led to significant progress towards minimising side effects associated with systemic exposure, additional opportunities exist for further enhancement of the therapeutic index. Recent developments in the molecular and structural understanding of corticosteroid biology have made it increasingly clear that novel corticosteroids with intrinsically different pharmacology can be designed.
authors.affiliation: Respiratory and Inflammation Center of Excellence for Drug Discovery, GlaxoSmithKline, Gunnels Wood Road, Stevenage, UK.
authors.forename: Iain J
authors.initials: IJ
authors.lastname: Uings
authors.forename: Stuart N
authors.initials: SN
authors.lastname: Farrow
mesh_terms: D000305:Adrenal Cortex Hormones / Q000494:pharmacology / Q000502:physiology / Q000627:therapeutic use; D000818:Animals; D001249:Asthma / Q000188:drug therapy*; D006801:Humans; D008024:Ligands; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy*; D011965:Receptors, Glucocorticoid / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D013329:Structure-Activity Relationship
chemical_list: D000305:Adrenal Cortex Hormones; D008024:Ligands; D011965:Receptors, Glucocorticoid