title: Atenolol or butoxamine injection at the lateral septum doesn't inhibit male sexual behavior in rats.
abstract: To investigate the role of specific adrenoreceptors subtypes on sexual behavior, atenolol, butoxamine, a mixture of atenolol and butoxamine, and saline (vehicle) were injected into the lateral septum in four different groups of sexually active male rats. Application of a mixture of atenolol and butoxamine produced inhibition of copulatory activity. On the other hand, application of either atenolol or butoxamine alone did not inhibit copulatory activity. But it produced stimulation of some of the components of male sexual behavior. Inability of either atenolol or butoxamine to inhibit the male sexual behavior, and inhibition of the same by the mixture of atenolol and butoxamine, indicate that both beta-adrenoreceptors at the lateral septum are involved in the elaboration of male sexual behavior. Stimulation of some components of sexual behavior on application of atenolol or butoxamine could be attributed to an unbalanced activity of beta-adrenoreceptors.
authors.affiliation: Department of Physiology, All India Institute of Medical Sciences, New Delhi - 110 029.
authors.forename: K K
authors.initials: KK
authors.lastname: Gulia
authors.forename: H N
authors.initials: HN
authors.lastname: Mallick
authors.forename: V M
authors.initials: VM
authors.lastname: Kumar
mesh_terms: D000818:Animals; D001262:Atenolol / Q000008:administration & dosage*; D002078:Butoxamine / Q000008:administration & dosage*; D004338:Drug Combinations; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D012686:Septal Nuclei / Q000187:drug effects* / Q000502:physiology; D012726:Sexual Behavior, Animal / Q000187:drug effects* / Q000502:physiology
chemical_list: D004338:Drug Combinations; D011943:Receptors, Adrenergic, beta; D002078:Butoxamine; D001262:Atenolol