Variable omeprazole kinetics in healthy Jordanian adults.
OBJECTIVE
The objective of this study was to examine the pharmacokinetics of orally administered omeprazole in healthy adult Jordanian men.


METHODS
Plasma concentrations of omeprazole were measured over a 12 h period after administration of a single oral dose of 40 mg omeprazole (Losec), AstraZeneca, UK). Subjects were healthy adult Jordanian men age 18-38 (24 +/- 4, mean +/- SD). The pharmacokinetic parameters were derived from the plasma concentration-time profiles for AUC(0-t), AUC(0-inf), C(max), t(max), t(1/2e) and K(e).


RESULTS
The pharmacokinetic of omeprazole were scattered over a wide range. The median AUC(0-inf) was 784.86 +/- 1182.88 (ng.h/ml), and the median C(max) was 521 +/- 354 (ng/ml) (median +/- SD). In general, most subjects showed normal distribution (approximately 90%). Some subjects (10%) did show very high AUC and C(max) compared with the reported AUC and C(max) levels. These subjects had higher half-lives and lower rates of elimination.


CONCLUSIONS
Significant difference in the pharmacokinetics of omeprazole after a single dose administration was noted. Approximately 10% of the study group showed very high omeprazole plasma levels and AUCs. Differences in the pharmacokinetics might be due to differences in the genetic make-up of subjects.
Albsoul-Younes
Abla
A
Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science & Technology, Jordan. ablabsou@just.edu.jo
Tayyem
Rabab
R
Najib
Naji
N
D000284:Administration, Oral; D000328:Adult; D000897:Anti-Ulcer Agents / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D006207:Half-Life; D006801:Humans; D007597:Jordan; D008297:Male; D009853:Omeprazole / Q000097:blood / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D000897:Anti-Ulcer Agents; D009853:Omeprazole