title: [Changes of circulating IFN-gamma, IL-4 in patients with chronic periodontitis before and after periodontal initial therapy].
abstract: OBJECTIVE
  To investigate the effect of periodontal initial therapy on circulating blood serum interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) in patients with chronic periodontitis.
  
  
  METHODS
  15 patients with chronic periodontitis and 15 healthy people were selected. Circulating blood serum IFN-gamma and IL-4 were measured using double antibody sandwich ELISA; Student's t test was used for comparing sulcus bleeding index (SBI), probing depth (PD), and circulating IFN-gamma, IL-4 in patients with chronic periodontitis that were assessed respectively before and 4 to 6 weeks after periodontal initial therapy.
  
  
  RESULTS
  The level of blood serum IFN-gamma, IL-4 in patients with chronic periodontitis was significantly higher than the control group (P<0.01); After periodontal initial therapy, SBI, PD, and circulating IFN-gamma concentration were reduced significantly (P<0.01); IL-4 concentration had no significant difference (P>0.05).
  
  
  CONCLUSIONS
  Blood serum IFN-gamma, IL-4 were associated with chronic periodontitis; The control of gingival infection may reduce blood serum IFN-gamma concentration; IL-4 concentration was not reduced with the control of gingival infection. Periodontal initial therapy.
authors.affiliation: Department of Periodontology, School of Stomatology, Shandong University, Jinan 250012, Shandong Province, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zong
authors.forename: Pi-shan
authors.initials: PS
authors.lastname: Yang
authors.forename: Xiang-min
authors.initials: XM
authors.lastname: Qi
authors.forename: Xin-hao
authors.initials: XH
authors.lastname: Yi
mesh_terms: D055113:Chronic Periodontitis / Q000453:epidemiology / Q000378:metabolism* / Q000628:therapy; D005881:Gingiva / Q000378:metabolism; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism*; D015847:Interleukin-4 / Q000378:metabolism*
chemical_list: D015847:Interleukin-4; D007371:Interferon-gamma