Evi-1 expression in Xenopus.
The Evi-1 gene was first identified as a site for viral integration in murine myeloid leukemia. Evi-1 is a zinc finger transcription factor that has been implicated in the development of myeloid neoplasia. In humans, disruption of the Evi-1 locus, by chromosomal rearrangements, is associated with myeloid leukemia and myelodyplastic syndromes. Here, we report the cloning and developmental pattern of expression of Xenopus Evi-1. xEvi-1 is expressed during oogenesis and during embryonic development. In situ hydridization reveals that xEvi-1 has a dynamic expression profile during early embryonic development. Expression of Evi-1 is detected by in situ hybridization in the pronephric tissue, the brain and in neural crest derivatives of the head and neck.
Mead
Paul E
PE
Department of Pathology, St Jude Children's Research Hospital, Memphis, TN 38105, USA. paul.mead@stjude.org
Parganas
Evan
E
Ohtsuka
Shiro
S
Morishita
Kazuhiro
K
Gamer
Laura
L
Kuliyev
Emin
E
Wright
Christopher V E
CV
Ihle
James N
JN
D000595:Amino Acid Sequence; D000818:Animals; D015152:Blotting, Northern; D001921:Brain / Q000378:metabolism; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000096:biosynthesis*; D018507:Gene Expression Regulation, Developmental; D015723:Gene Library; D017403:In Situ Hybridization; D007668:Kidney / Q000196:embryology; D000074008:MDS1 and EVI1 Complex Locus Protein; D051379:Mice; D008969:Molecular Sequence Data; D009432:Neural Crest / Q000378:metabolism; D009865:Oocytes / Q000378:metabolism; D011061:Poly A / Q000737:chemistry; D011519:Proto-Oncogenes; D017386:Sequence Homology, Amino Acid; D013997:Time Factors; D014157:Transcription Factors / Q000096:biosynthesis*; D014158:Transcription, Genetic; D014982:Xenopus laevis
D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D000074008:MDS1 and EVI1 Complex Locus Protein; C499305:Mecom protein, mouse; D014157:Transcription Factors; D011061:Poly A