[Expressions of transforming growth factor-beta1 and collagen IV in renal tissues of patients with chronic allograft nephropathy].
OBJECTIVE
To investigate the expressions of transforming growth factor (TGF)-beta1 and collagen IV in the renal tissues of patients with chronic allograft nephropathy (CAN).


METHODS
Immunohistochemical method and computer-assisted image analysis system were used to detect the expressions of TGF-beta1 and collagen IV in the renal tissues of patients with CAN, and the association between TGF-beta1 and collagen IV expressions as well as that between their expressions and the pathological grading of CAN were analyzed.


RESULTS
The expressions of TGF-beta1 and collagen IV were significantly higher in the renal tissues of the patients than in normal renal tissues (P<0.001), and the expressions tended to increase with the pathological grades of CAN; TGF-beta1 and collagen IV expressions in both the renal glomeruli and the tubulointerstitium were in patients with CAN positively correlated with normal renal tissues (r=0.943, P<0.001; r=0.910, P<0.001).


CONCLUSIONS
Abnormal collagen IV deposition is one of the major factors associated with renal fibrosis in CAN, and TGF-beta1 might play an important role in renal fibrosis in CAN through up-regulation of collagen IV in the renal tissues.
Han
Cong-xiang
CX
Department of Kidney Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. xiangzi4318@sina.com
Yu
Li-xin
LX
Xu
Jian
J
Xie
Qing-xiang
QX
Wang
Yi-bin
YB
Deng
Wen-feng
WF
Liu
Xiao-you
XY
Zeng
Jing-hua
JH
D002908:Chronic Disease; D024141:Collagen Type IV / Q000096:biosynthesis* / Q000235:genetics; D005355:Fibrosis / Q000378:metabolism; D006084:Graft Rejection / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D007674:Kidney Diseases / Q000378:metabolism* / Q000473:pathology; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology; D011183:Postoperative Complications / Q000276:immunology / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000096:biosynthesis* / Q000235:genetics; D014184:Transplantation, Homologous / Q000276:immunology / Q000473:pathology
D024141:Collagen Type IV; D016212:Transforming Growth Factor beta