[Investigation on the relation between systemic inflammatory response syndrome and severity of acute pancreatitis].
OBJECTIVE
To explore the relationship between the systemic inflammatory response syndrome (SIRS) and the severity of the acute pancreatitis, so as to provide some leads in the treatment to lower the mortality of severe acute pancreatitis.


METHODS
One hundred and seventy-two patients suffering from acute pancreatitis admitted to our departments from January 1, 2001 to December 31, 2003 were retrospectively analyzed. The patients were divided into survivor group and non-survivor group, and patients in the survivor group were further divided into severe group and mild group according to scores of acute physiology and chronic health evaluation II (APACHE II). The scores of APACHE II were compared between patients without SIRS and those who met the criteria of SIRS.


RESULTS
There was significant difference between the survivor group and non-survivor group not only in the incidence of patients who developed SIRS, but also in the number of patients fulfilling or not fulfilling the diagnostic criteria of SIRS between the severe group and mild group. There was also significant statistical difference between the SIRS group and non-SIRS group in the APACHE II scoring. Significant difference in duration of SIRS was found between the severe group and mild group.


CONCLUSIONS
SIRS is highly correlated with the severity of acute pancreatitis. Active prevention and treatment of SIRS may raise the survival rate of severe acute pancreatitis.
Du
Wei
W
Department of Infectious Diseases and Critical Care Medicine, Beijing 100050, China.
Wang
Hong
H
Zhang
Shu-wen
SW
Wang
Bao-en
BE
D018806:APACHE; D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000150:complications*; D011379:Prognosis; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology*; D055815:Young Adult