Error-prone DNA repair and translesion DNA synthesis. II: The inducible SOS hypothesis.
Evelyn Witkin hypothesized in 1967 that bacterial cell division is controlled by a repressor which, like the lambda repressor, is inactivated by a complex process that starts with the presence of replication-blocking lesions in the DNA. She further suggested that this might not be the only cellular function to show induction by DNA damage. Three years later, Miroslav Radman, in a privately circulated note, proposed that one such function might be an inaccurate (mutation-prone) DNA polymerase under the control of the recA and lexA genes. Thus was born the SOS hypothesis.
Bridges
Bryn A
BA
Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK. b.a.bridges@sussx.ac.uk
D004260:DNA Repair; D004261:DNA Replication; D004269:DNA, Bacterial; D004307:Dose-Response Relationship, Radiation; D004926:Escherichia coli / Q000235:genetics* / Q000528:radiation effects; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D009154:Mutation; D013014:SOS Response, Genetics; D014466:Ultraviolet Rays
D004269:DNA, Bacterial