Acinetobacter baumannii: emergence and spread in Israeli hospitals 1997-2002.
The incidence of multi-drug-resistant Acinetobacter baumannii bloodstream infections (BSIs) increased two- to four-fold in three Israeli hospitals between 1997 and 2002, accounting for 3.5-18% of all hospital-acquired BSIs. This was associated with increasing carbapenem resistance reaching 35-54%, and by a dramatic increase in carbapenem consumption. In-hospital fatality rates ranged between 47% and 58% and were significantly higher than those seen with other nosocomial Gram-negative pathogens. A. baumannii was not restricted to intensive care units, but had spread to all hospital wards. Multi-drug-resistant A. baumannii has the potential to reach endemicity in hospitals and warrants more vigorous and innovative efforts to limit its spread.
Paul
M
M
Department of Medicine and Infectious Diseases, Rabin Medical Centre, Beilinson Campus, Petach-Tikva, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. pil1pel@zahav.net.il
Weinberger
M
M
Siegman-Igra
Y
Y
Lazarovitch
T
T
Ostfeld
I
I
Boldur
I
I
Samra
Z
Z
Shula
H
H
Carmeli
Y
Y
Rubinovitch
B
B
Pitlik
S
S
D000151:Acinetobacter Infections / Q000453:epidemiology* / Q000401:mortality; D040981:Acinetobacter baumannii / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity*; D015780:Carbapenems / Q000494:pharmacology; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D004196:Disease Outbreaks; D024881:Drug Resistance, Bacterial; D017052:Hospital Mortality; D006801:Humans; D015994:Incidence; D007557:Israel / Q000453:epidemiology
D015780:Carbapenems