Living kidney donor follow-up in a dedicated clinic.
BACKGROUND
Long-term effects of uninephrectomy for kidney donation are of particular interest in the currently increasing practice of living-donor transplantation. We have retrospectively analyzed the general health status and renal and cardiovascular consequences of living-related kidney donation.


METHODS
Data of living-related kidney donors who were regularly followed up in a dedicated clinic at the Sindh Institute of Urology and Transplantation between July 2000 and January 2004 was retrieved. They had donated their kidneys from 1986 onward. Data on weight, blood pressure, creatinine clearance, level of proteinuria, and new onset diabetes mellitus were analyzed.


RESULTS
Seven hundred and thirty-six donors with a mean age of 36+/-10.9 years (M:F 1.1:1) were evaluated. With a mean postnephrectomy duration of 3+/-3.2 years (range 6 months-18 years), the creatinine clearance fell to 87% of prenephrectomy values, and 49 (6.7%) had a creatinine clearance of less than 60 mL/ min. Hypertension developed in 76 (10.3%) donors, and 179 (24.3%) had proteinuria exceeding 150 mg/24 hr. Overweight (27.8%) and obese subjects (11.5%) had a higher prevalence of hypertension and new onset diabetes mellitus. One donor developed end-stage renal failure.


CONCLUSIONS
Donor nephrectomy has minimal adverse effects on overall health status. Regular donor follow-up identifies at-risk populations and potentially modifiable factors.
Rizvi
S Adibul Hasan
SA
Sindh Institute of Urology and Transplantation (SIUT), Dow Medical College, Karachi, Pakistan. info@siut.org
Naqvi
Syed Ali Anwar
SA
Jawad
Fatema
F
Ahmed
Ejaz
E
Asghar
Ali
A
Zafar
Mirza Naqi
MN
Akhtar
Fazal
F
D000328:Adult; D001794:Blood Pressure; D003404:Creatinine / Q000097:blood / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D007668:Kidney; D019520:Living Donors; D008297:Male; D009392:Nephrectomy; D010154:Pakistan; D018579:Patient Selection; D011507:Proteinuria; D013997:Time Factors; D020858:Tissue and Organ Harvesting; D016896:Treatment Outcome
D003404:Creatinine