title: Syntheses and anti-inflammatory activity of diphenylamine-2,2'-dicarboxylic acid and its metal complexes.
abstract: Diphenylamine-2,2'-dicarboxylic acid and its Cu(II), Ni(II), Co(II) and Zn(II) complexes have been synthesized and characterized by their elemental analyses, molecular weight determination, molar conductance, infrared and electronic spectra and magnetic measurements. The Zinc complex was tested by different methods for its anti-inflammatory activity and found to be equipotent to naproxen and ibuprofen, though at higher doses.
authors.affiliation: Department of Pharmacology, S.N. Medical College, Agra-282 002, India. rohit210477@rediffmail.com
authors.forename: Govind
authors.initials: G
authors.lastname: Mohan
authors.forename: Rajesh
authors.initials: R
authors.lastname: Nagar
authors.forename: S C
authors.initials: SC
authors.lastname: Agarwal
authors.forename: Km Anugya
authors.initials: KA
authors.lastname: Mehta
authors.forename: C Sheshagiri
authors.initials: CS
authors.lastname: Rao
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology*; D016718:Arachidonic Acid / Q000633:toxicity; D001169:Arthritis, Experimental / Q000188:drug therapy; D002351:Carrageenan / Q000633:toxicity; D003436:Croton Oil / Q000633:toxicity; D003967:Diarrhea / Q000139:chemically induced / Q000188:drug therapy; D004159:Diphenylamine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D006099:Granuloma / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D019216:Metals, Heavy / Q000737:chemistry*; D051379:Mice; D008970:Molecular Weight; D011453:Prostaglandins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014456:Ulcer / Q000188:drug therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D019216:Metals, Heavy; D011453:Prostaglandins; D016718:Arachidonic Acid; D003436:Croton Oil; D002351:Carrageenan; D004159:Diphenylamine