title: A highly automated, polymer-assisted strategy for the preparation of 2-alkylthiobenzimidazoles and N,N'-dialkylbenzimidazolin-2-ones.
abstract: A multistep, polymer-assisted solution phase strategy for the highly automated (auto-PASP) synthesis of 2-alkylthiobenzimidazole and N,N'-dialkylbenzimidazolin-2-one libraries is presented. The approach incorporates in-line purification techniques to afford library products directly with high purities and is exemplified by the preparation of a 96-member 2-alkylthiobenzimidazoline library 1[1-12,1-8] and a 72-member N,N'-dialkylbenzimidazolin-2-one library 9[1-12,1-6].
authors.affiliation: GlaxoSmithKline Cambridge Technology Centre, University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, United Kingdom.
authors.forename: Emma
authors.initials: E
authors.lastname: Vickerstaffe
authors.forename: Brian H
authors.initials: BH
authors.lastname: Warrington
authors.forename: Mark
authors.initials: M
authors.lastname: Ladlow
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley