[Features of gastroesophageal reflux disease in young people].
The article contains ethiopathogenic, clinical and diagnostic criteria of gastroesophageal reflux disease (GERD) in young people. GERD verification was based upon the results of the examination of 137 men aged 18 to 23 years. These results included clinical findings as well as the data from the following tests: intraesophageal and intragastric pH-metry with evaluation of parietal cell response to atropine, and endoscopic and morphological examination of the upper division of the gastrointestinal tract including detection of Helicobacter pylori (HP) expansion, evaluation of inflammatory and regenerative processes in the mucosa of the lower third of the esophagus and the antral part of the stomach. The results show that the feature of GERD in the given age group is a certain morphological picture in the esophagus characterized by a various degree of squamous epithelium dystrophy with almost no metaplasia, as well as a high degree of HP adhesion in the esophagus with atropine-resistent hyperchlorhydria in the stomach. It shoud be noted that eradicational and antisecretory therapy in young people with GERD leads to the reestablishment of the esophagial mucosa structure.
Osadchuk
M A
MA
Usik
S F
SF
Iurchenko
I N
IN
Zolotovitskaia
A M
AM
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001706:Biopsy; D016145:Endoscopy, Digestive System; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology; D005764:Gastroesophageal Reflux / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D016998:Helicobacter / Q000302:isolation & purification; D016481:Helicobacter Infections / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D011379:Prognosis; D012720:Severity of Illness Index