title: Survival in high-grade glioma: a study of survival in patients unfit for or declining radiotherapy.
abstract: OBJECTIVE
  To determine the survival of patients with high-grade glioma (HGG) and a poor prognosis in terms of age or performance status managed with best supportive care alone.
  
  
  METHODS
  An analysis of survival was carried out on 123 patients with HGG declining or judged unfit to receive radiotherapy, on the basis of age or performance status, between February 1998 and October 2003. Karnofsky performance status (KPS), biopsy or resection or no surgery, attendance at clinic and reason for not receiving radiotherapy were prospectively recorded.
  
  
  RESULTS
  Of the 123 patients, three were excluded from the analysis, as no outcome data were available. Median age was 66 years (range 29-91 years), and median KPS was 50 (range 30-100). All 120 patients included had died at the time of analysis. Overall median survival was 68 days (95% CI 56-85), range 2-294 days and interquartile range 35-123 days. Median survival of 22 patients declining radiotherapy was 75 days (95% CI 53-123), of 98 patients unfit for radiotherapy 67 days (95% CI 48-88); non-significant difference P = 0.36. Median survival of 26 patients undergoing biopsy was 95 days (95% CI 66-123), of 56 undergoing surgical resection 74 days (95% CI 47-93), and of 38 receiving no surgical intervention 59 days (95% CI 47-70); non-significant difference P = 0.16.
  
  
  CONCLUSIONS
  For patients with HGG and a poor prognosis, in terms of age or performance status managed with best supportive care, survival is short. Survival may be too short to benefit from radiotherapy and possibly surgery.
authors.affiliation: Cookridge Hospital, Yorkshire Centre for Clinical Oncology, Leeds, UK.
authors.forename: R J
authors.initials: RJ
authors.lastname: Prestwich
authors.forename: A
authors.initials: A
authors.lastname: Sivapalasunrtharam
authors.forename: C
authors.initials: C
authors.lastname: Johnston
authors.forename: K
authors.initials: K
authors.lastname: Evans
authors.forename: G E
authors.initials: GE
authors.lastname: Gerrard
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D005260:Female; D005910:Glioma / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016019:Survival Analysis