PMUT: a web-based tool for the annotation of pathological mutations on proteins.
PMUT allows the fast and accurate prediction (approximately 80% success rate in humans) of the pathological character of single point amino acidic mutations based on the use of neural networks. The program also allows the fast scanning of mutational hot spots, which are obtained by three procedures: (1) alanine scanning, (2) massive mutation and (3) genetically accessible mutations. A graphical interface for Protein Data Bank (PDB) structures, when available, and a database containing hot spot profiles for all non-redundant PDB structures are also accessible from the PMUT server.
Ferrer-Costa
Carles
C
Molecular Modeling and Bioinformatics Unit, Institut de Recerca Biomédica, Parc Científic de Barcelona Josep Samitier 1-5, Barcelona 08028, Spain.
Gelpí
Josep Lluis
JL
Zamakola
Leire
L
Parraga
Ivan
I
de la Cruz
Xavier
X
Orozco
Modesto
M
D019943:Amino Acid Substitution; D003198:Computer Simulation; D020407:Internet; D008956:Models, Chemical; D008958:Models, Molecular; D016297:Mutagenesis, Site-Directed; D016571:Neural Networks, Computer; D011506:Proteins / Q000032:analysis / Q000737:chemistry*; D016415:Sequence Alignment / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*; D012984:Software; D014584:User-Computer Interface
D011506:Proteins