Dendrimeric Gd(III) complex of a monophosphinated DOTA analogue: optimizing relaxivity by reducing internal motion.
A marked increase of relaxivity has been observed upon rigidifying the internal frame of Gd-containing PAMAM dendrimers: the effect has been attained by either protonation of the dendrimer or by forming supramolecular adducts with cationic polyaminoacids.
Rudovsky
Jakub
J
Department of Inorganic Chemistry, Universita Karlova, Hlavova 2030, 128 40, Prague 2, Czech Republic. petrh@natur.cuni.cz
Hermann
Petr
P
Botta
Mauro
M
Aime
Silvio
S
Lukes
Ivan
I
D050091:Dendrimers; D005682:Gadolinium / Q000737:chemistry*; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011073:Polyamines / Q000737:chemistry*
D050091:Dendrimers; D006573:Heterocyclic Compounds, 1-Ring; D009942:Organometallic Compounds; C104700:PAMAM Starburst; D011073:Polyamines; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid; D005682:Gadolinium