Eukaryotic transcription activation: right on target.
The unambiguous identification of the direct targets of eukaryotic transcriptional activators has been a major challenge in the field. Recently, the authentic targets of several yeast and mammalian activators have been determined, and the results of these studies have important implications for our understanding of transcriptional activation mechanisms.
Green
Michael R
MR
Howard Hughes Medical Institute, Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA. michael.green@umassmed.edu
D000818:Animals; D051548:Histone Acetyltransferases; D008322:Mammals / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D014158:Transcription, Genetic / Q000502:physiology*; D015533:Transcriptional Activation / Q000502:physiology*; D015003:Yeasts / Q000235:genetics / Q000378:metabolism
D029701:Saccharomyces cerevisiae Proteins; C491364:TRA1 protein, S cerevisiae; D051548:Histone Acetyltransferases