Antileishmanial and antifungal activities of xanthanolides isolated from Xanthium macrocarpum.
Seven xanthanolides, xanthinosin, xanthatin, 4-hydroxyxanthinosin, xanthinin, 4-epiisoxanthanol, 4-epixanthanol, 2-hydroxyxanthinosin and 4-oxobedfordia acid, were isolated from the fruits of Xanthium macrocarpum. A valuation of the antifungal activity of these xanthanolides against Candida albicans, Candida glabrata and Aspergillus fumigatus and of their antileishmanial activity against Leishmania infantum and Leishmania mexicana is presented.
Lavault
Marie
M
SONAS UPRES-EA 921, UFR des Sciences Pharmaceutiques et Ingéniérie de la santé, 16 Bd Daviers, Angers, France.
Landreau
Anne
A
Larcher
Gérald
G
Bouchara
Jean-Philippe
JP
Pagniez
Fabrice
F
Le Pape
Patrice
P
Richomme
Pascal
P
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D005658:Fungi / Q000187:drug effects; D007891:Leishmania / Q000187:drug effects*; D018515:Plant Leaves / Q000737:chemistry; D031210:Xanthium / Q000737:chemistry*
D000935:Antifungal Agents; D000981:Antiprotozoal Agents