[Expression of platelet CD62p gene and leucocyte HSP70 gene in patients with blood stasis syndrome MA].
OBJECTIVE
To investigate microcosmic essentials of blood stasis syndrome (BSS) at the gene level.


METHODS
One hundred and sixty patients with hypertension or diabetes mellitus, BSS or non-BSS, were strictly selected in disease-syndrome integrated mode according to diagnosis standard. The expression of CD62p gene and HSP70 gene in them were observed, compared and analyzed with blood biochemical indexes by experimental techniques, and compared to those in healthy subjects as control, for exploring the microcosmic mechanism and evolutive rules of BSS formation at the gene level.


RESULTS
It was showed, through determination and analysis of the microcosmic indexes closely associated with BSS, that the expression of CD62p gene and HSP70 gene were abnormal in patients with BSS, they were increased in patients with BBS and significantly higher than those in healthy subjects (P < 0.01). The abnormality and level of them were closely correlated with the types of BSS.


CONCLUSIONS
CD62p gene and HSP70 gene might be closely associated with BSS.
Min
M A
MA
Department of Traditional Chinese Medicine, Medical College, Jinan University, Guangzhou. tmamin@jnu.edu.cn
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001792:Blood Platelets / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000235:genetics; D003937:Diagnosis, Differential; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000235:genetics; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D019007:P-Selectin / Q000096:biosynthesis* / Q000235:genetics
D018840:HSP70 Heat-Shock Proteins; D019007:P-Selectin