title: Incidental pediatric intraparenchymal xanthogranuloma: case report and review of the literature.
abstract: Juvenile xanthogranuloma (JXG) is a specialized form of non-Langerhans cell histiocyte proliferation that occurs in children. The majority of cases present as a solitary cutaneous lesion with a predilection for the head and neck region; however, isolated lesions occasionally have been identified in the central nervous system. The cutaneous forms of JXG usually follow a benign course. Other physicians have reported surgery as the first line of treatment in symptomatic patients with accessible lesions. Adjuvant therapies may be indicated for multicentric or surgically inaccessible lesions. The authors describe an unusual case of isolated intraparenchymal JXG in an asymptomatic child with no cutaneous manifestations and provide a review of the literature.
authors.affiliation: Department of Neurological Surgery, Division of Pediatric Neurosurgery, St Louis Children's Hospital, St Louis, Missouri 63110, USA.
authors.forename: William W
authors.initials: WW
authors.lastname: Ashley
authors.forename: Prithvi
authors.initials: P
authors.lastname: Narayan
authors.forename: Tae Sung
authors.initials: TS
authors.lastname: Park
authors.forename: Pang-hsien
authors.initials: PH
authors.lastname: Tu
authors.forename: Arie
authors.initials: A
authors.lastname: Perry
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Leonard
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D001402:B-Lymphocytes / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis* / Q000601:surgery*; D002648:Child; D004292:Dominance, Cerebral; D015944:Factor VIIIa / Q000032:analysis; D005625:Frontal Lobe / Q000473:pathology / Q000601:surgery; D016489:Head Injuries, Closed / Q000175:diagnosis*; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D033162:Incidental Findings; D008279:Magnetic Resonance Imaging; D008297:Male; D013601:T-Lymphocytes / Q000473:pathology; D003336:Tectum Mesencephali / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014972:Xanthogranuloma, Juvenile / Q000175:diagnosis* / Q000601:surgery*; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D015944:Factor VIIIa; C067980:CD68 antigen, human; D000097382:CD68 Molecule