title: Does platelet-rich plasma promote remodeling of autologous bone grafts used for augmentation of the maxillary sinus floor?
abstract: The aim of this study was to evaluate the effect of platelet-rich plasma (PRP) on remodeling of autologous bone grafts used for augmentation of the floor of the maxillary sinus. In five edentulous patients suffering from insufficient retention of their upper denture related to a severely resorbed maxilla, the floor of both maxillary sinus was augmented with an autologous bone graft from the iliac crest. Randomly, PRP was added to the bone graft used to augment the floor of the left or right sinus (split-mouth design). Three months after the reconstruction, bone biopsies were taken with a trephine from the planned implant sites (N=30). Subsequently, three implants were placed in the left and right posterior maxilla. Microradiograms were made of all biopsies (N=30), whereafter the biopsies were processed for light microscopic examination. In addition, clinical parameters were scored. Wound healing was uneventful, clinically no difference was observed between the side treated with PRP or not. Also microradiographical and histomorphological examination of the biopsies revealed no statistical difference between the PRP- and non-PRP side. One implant placed in the PRP side of the graft was lost during the healing phase. Implant-retained overdentures were fabricated 6 months after implantation. All patients functioned well (follow-up 20.2+/-4.3 months). In this study, no beneficial effect of PRP on wound healing and bone remodeling was observed. It is posed that PRP has no additional value in promoting healing of grafted non-critical size defects.
authors.affiliation: Department of Oral and Maxillofacial Surgery and Maxillofacial Prosthetics, University Hospital Groningen, PO Box 30.001, 9700 RB Groningen, the Netherlands. g.m.raghoebar@kchir.azg.nl
authors.forename: Gerry M
authors.initials: GM
authors.lastname: Raghoebar
authors.forename: Jurjen
authors.initials: J
authors.lastname: Schortinghuis
authors.forename: Robert S B
authors.initials: RS
authors.lastname: Liem
authors.forename: Jan L
authors.initials: JL
authors.lastname: Ruben
authors.forename: Jacqueline E
authors.initials: JE
authors.lastname: van der Wal
authors.forename: Arjan
authors.initials: A
authors.lastname: Vissink
mesh_terms: D001792:Blood Platelets / Q000378:metabolism; D001861:Bone Regeneration / Q000187:drug effects* / Q000502:physiology; D016025:Bone Transplantation / Q000379:methods*; D003757:Dental Implantation; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008443:Maxillary Sinus / Q000000981:diagnostic imaging / Q000502:physiology / Q000601:surgery*; D008852:Microradiography; D008875:Middle Aged; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D016212:Transforming Growth Factor beta