title: Diaphragmatic pathology: a cause of clinically unexplained death in the perinatal/paediatric age group.
abstract: Sudden unexpected death in infancy and childhood requires a 'full' post-mortem investigation. Guidance from the Royal College of Pathologists recommends sampling of all the major organs. However, the diaphragm does not feature in this or in most lists of routine histology. Our aim is to emphasize the importance of sampling the diaphragm for histological examination during autopsy. We describe three autopsy cases of clinically unexplained death in the perinatal and paediatric age group that showed significant pathology of the diaphragm. In Case 1, a previously healthy five-year-old girl collapsed suddenly and died four days later. In Case 2, an eight-month-old infant had repeated episodes of respiratory arrest that culminated in death. Autopsy demonstrated a predominantly diaphragmatic myositis. In Case 3 a female neonate had a respiratory arrest three days after birth and died less than a month later. Autopsy showed multiple large calcified necrotic fibres in the diaphragm. The diaphragm is seldom sampled at autopsy. In the first two cases a predominantly diaphragmatic myositis was either the direct or underlying cause of death. In the third case long-standing diaphragmatic pathology of uncertain cause may have contributed to the original respiratory arrest. Had the diaphragm not been examined histologically, the cause of death would have remained unascertained in these cases. In cases of sudden death in infancy and childhood, failure to reach a diagnosis may lead to undue suspicion falling upon the child's carers. This underscores the need for full histology at post-mortem in child deaths, including diaphragmatic sampling.
authors.affiliation: Department of Histopathology, Birmingham Women's Hospital, Birmingham B15 2TG.
authors.forename: S
authors.initials: S
authors.lastname: Sundararajan
authors.forename: N S
authors.initials: NS
authors.lastname: Ostojic
authors.forename: D I
authors.initials: DI
authors.lastname: Rushton
authors.forename: P M
authors.initials: PM
authors.lastname: Cox
authors.forename: P
authors.initials: P
authors.lastname: Acland
mesh_terms: D001344:Autopsy / Q000379:methods*; D002114:Calcinosis / Q000473:pathology; D002675:Child, Preschool; D003964:Diaphragm / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009220:Myositis / Q000473:pathology; D009336:Necrosis / Q000473:pathology; D012131:Respiratory Insufficiency / Q000473:pathology*