[Specific features of protease and antiprotease activity of blood in women with external endometriosis].
32 healthy fertile women (control group) and 94 women with different-severity external endometriosis (EE) were examined. The activity of cathepsin D, plasminogen, AT-III, protein C, acid alpha1-antitrypsin as well as the parameters of antiprothrombin, thrombin and prothrombin time were investigated in serum of venous blood. In EE, the below parameters were found to be essentially increased: thrombin time--35.69 +/- 5.77 sec (controls--20.2 +/- 0.8 sec, p < 0.05), prothrombin time--30.43 +/- 7.21 sec (controls--21.6 +/- 0.8, p < 0.05), concentration of alpha2 macroglobulin--489.3 +/- 39.71 mg/dl (controls--240.2 +/- 12.2 mg/dl, p < 0.001), and AT-III activity--127.37 +/- 7.13% (controls--98.2 +/- 2.56, p < 0.001); at the same time, the parameters of plasmin were decreased--108.00 +/- 5.28% (controls--169 +/- 18%, p < 0.01).
Gerasimov
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D000328:Adult; D015415:Biomarkers / Q000097:blood; D004715:Endometriosis / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012697:Serine Endopeptidases / Q000097:blood*; D015842:Serine Proteinase Inhibitors / Q000097:blood*
D015415:Biomarkers; D015842:Serine Proteinase Inhibitors; D012697:Serine Endopeptidases