Protective effect of curcumin during selenium induced toxicity on dehydrogenases in hepatic tissue.
Selenium administration resulted in a marked decrease in the activity levels of the liver succinate dehydrogenase, malate dehydrogenase, and lactate dehydrogenase while pyruvate dehydrogenase increased significantly (P<0.001) in the wistar rat. The degree of decrease of these enzymes was significantly less (P<0.001) when rats were treated with curcumin, a natural constituent Curcuma longa. Curcumin seems to prevent oxidative damage mediated through selenium and protect the dehydrogenases possibly through its anti-oxidative property.
Padmaja
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Physiology Division, Department of Zoology, University College of Science, Osmania University, Hyderabad - 500 007.
Raju
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D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage; D003474:Curcumin / Q000008:administration & dosage*; D004791:Enzyme Inhibitors / Q000008:administration & dosage; D007770:L-Lactate Dehydrogenase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology*; D008291:Malate Dehydrogenase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000633:toxicity*; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000975:Antioxidants; D004791:Enzyme Inhibitors; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D013385:Succinate Dehydrogenase; D012643:Selenium; D003474:Curcumin