title: Total and regional body composition and energy expenditure in multiple symmetric lipomatosis.
abstract: OBJECTIVE
  The aim of the present study was to investigate possible alterations in body composition and resting energy expenditure (REE) in type 1 multiple symmetric lipomatosis (MSL).
  
  
  METHODS
  Thirteen men aged from 40 to 78 years affected by type I MSL were compared with 13 healthy control subjects. Fat mass (FM) and fat-free mass (FFM) were determined by DEXA using both standard analysis and specifically for the lipomatous region. REE was measured by indirect calorimetry.
  
  
  RESULTS
  FM was higher in MSL subjects at proximal arm level, but significantly lower at distal leg level than in controls (left 1.63+/-0.55 vs. 2.26+/-0.49 kg, P<0.05; right 1.63+/-0.53 vs. 2.40+/-0.54 kg, P<0.01). Arm FFM was similar in the two groups, while distal leg FFM was significantly lower in MSL cases (left: 7.8+/-1.3 vs. 8.7+/-0.8 kg, P<0.05; right: 8.0+/-1.5 vs. 9.2+/-0.9 kg, P<0.05). FFM strongly correlated with REE (r:0.86;P<0.001). REE, expressed as an absolute value and adjusted for FFM (1830+/-215 vs. 1675+/-120 kcal, P<0.05) was higher in MSL patients.
  
  
  CONCLUSIONS
  In conclusion, MSL patients had a marked FFM and FM atrophy in the lower segments of the legs and an altered energy expenditure (hypermetabolism).
authors.affiliation: Department of Medical and Surgical Sciences, Geriatrics Division, University of Padova, Via Giustiniani, 2,35128 Padova, Italy. alessandra.coin@unipd.it
authors.forename: Alessandra
authors.initials: A
authors.lastname: Coin
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Sergi
authors.forename: Giuliano
authors.initials: G
authors.lastname: Enzi
authors.forename: Luca
authors.initials: L
authors.lastname: Busetto
authors.forename: Sabrina
authors.initials: S
authors.lastname: Pigozzo
authors.forename: Lucia
authors.initials: L
authors.lastname: Lupoli
authors.forename: Dinah
authors.initials: D
authors.lastname: Sträter
authors.forename: Silvia
authors.initials: S
authors.lastname: Peruzza
authors.forename: Emine Meral
authors.initials: EM
authors.lastname: Inelmen
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D001481:Basal Metabolism; D001823:Body Composition; D002153:Calorimetry, Indirect; D004734:Energy Metabolism; D006801:Humans; D008069:Lipomatosis, Multiple Symmetrical / Q000378:metabolism*; D008297:Male; D008875:Middle Aged