title: MR imaging-guided interstitial photodynamic laser therapy for advanced head and neck tumors.
abstract: Photodynamic therapy (PDT) is a site-specific tumor treatment involving the administration of a photosensitizer activated by the local application of light. In interstitial PDT (IPDT), multiple laser fibers are inserted into the depth of the tumor. Image guidance is essential for accurate, safe, and uniform light delivery. We report a novel technique of IPDT for advanced head and neck tumors involving an open interventional MR system. Initial results are encouraging, with minimal procedural morbidity, successful palliation of symptoms, and prolongation of expected survival time.
authors.affiliation: Department of Imaging, University College Hospital, London, United Kingdom.
authors.forename: H Rolf
authors.initials: HR
authors.lastname: Jäger
authors.forename: Magali N
authors.initials: MN
authors.lastname: Taylor
authors.forename: Tamer
authors.initials: T
authors.lastname: Theodossy
authors.forename: Colin
authors.initials: C
authors.lastname: Hopper
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D053685:Laser Therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000628:therapy*; D010166:Palliative Care; D010778:Photochemotherapy