Disruption of protein-protein interactions: towards new targets for chemotherapy.
Protein-protein interactions play a key role in various mechanisms of cellular growth and differentiation, and in the replication of pathogen organisms in host cells. Thus, inhibition of these interactions is a promising novel approach for rational drug design against a wide number of cellular and microbial targets. In the past few years, attempts to inhibit protein-protein interactions using antibodies, peptides, and synthetic or natural small molecules have met with varying degrees of success, and these will be the focus of this review.
Loregian
Arianna
A
Department of Histology, Microbiology, and Medical Biotechnologies, University of Padova, Italy. arianna.loregian@unipd.it
Palù
Giorgio
G
D000818:Animals; D017209:Apoptosis; D015195:Drug Design; D006801:Humans; D008024:Ligands; D011485:Protein Binding / Q000187:drug effects; D011506:Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism*
D008024:Ligands; D011506:Proteins