title: Fungemia due to Trichosporon asahii in a neutropenic child refractory to amphotericin B: clearance with voriconazole.
abstract: Disseminated Trichosporon infection in neutropenic patients carries a poor prognosis. Clinical evidence on the use of voriconazole for this infection is limited. The authors report a case of Trichosporon asahii fungemia refractory to liposomal amphotericin B treatment in a boy with acute lymphoblastic leukemia, which resolved after the addition of voriconazole. Both voriconazole and amphotericin B exhibited low minimal inhibitory concentrations and minimal fungicidal concentrations, and their combination was indifferent in vitro. The use of voriconazole for the treatment of trichosporonosis in patients with hematologic malignancies deserves further study.
authors.affiliation: Third Department of Pediatrics, Aristotle University, Hippokration Hospital, Thessaloniki, Greece.
authors.forename: Charalampos
authors.initials: C
authors.lastname: Antachopoulos
authors.forename: Eugenia
authors.initials: E
authors.lastname: Papakonstantinou
authors.forename: John
authors.initials: J
authors.lastname: Dotis
authors.forename: Evangelia
authors.initials: E
authors.lastname: Bibashi
authors.forename: Maria
authors.initials: M
authors.lastname: Tamiolaki
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Koliouskas
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Roilides
mesh_terms: D000293:Adolescent; D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D016469:Fungemia / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009181:Mycoses / Q000188:drug therapy*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma; D011743:Pyrimidines / Q000627:therapeutic use*; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*; D014250:Trichosporon / Q000145:classification / Q000302:isolation & purification*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D000666:Amphotericin B; D065819:Voriconazole