Genetic variants of myeloperoxidase and catechol-O-methyltransferase and breast cancer risk.
This nested case-control study evaluated the role of polymorphisms in the myeloperoxidase (MPO) and catechol-O-methyltransferase (COMT) genes that modulate oxidative stress in breast cancer risk in a Chinese population. Our results demonstrate that the MPO A/A genotype was associated with a reduced risk of breast cancer (odds ratio (OR) 0.64; 95% confidence interval (CI) 0.11-3.76), whereas there was no overall association of COMT genotype with breast cancer. Of note, an elevated breast cancer risk associated with the increasing numbers of high-risk genotypes of MPO and COMT genes was observed in women with a longer duration between menarche and first full-term pregnancy.
Lin
S-C
SC
School of Public Health, National Defense Medical Center, No. 161, Section 6 Min-Chuan East Road, Taipei 114, Taiwan, Republic of China.
Chou
Y-C
YC
Wu
M-H
MH
Wu
C-C
CC
Lin
W-Y
WY
Yu
C-P
CP
Yu
J-C
JC
You
S-L
SL
Chen
C-J
CJ
Sun
C-A
CA
D001943:Breast Neoplasms / Q000209:etiology* / Q000235:genetics*; D016022:Case-Control Studies; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D018384:Oxidative Stress; D009195:Peroxidase / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
D009195:Peroxidase; D002394:Catechol O-Methyltransferase