title: Unique three-way translocation, t(3;14;18)(q27;q32;q21), in follicular lymphoma.
abstract: A 43-year-old woman was diagnosed as having stage IV follicular lymphoma. Phenotypically, the lymphoma cells were CD5(-), CD10(+), CD19(+), CD20(+), CD23(-), HLA-DR(+), and IgM-lambda(+). Conventional chromosomal analysis showed a three-way t(3;14;18)(q27;q32;q21) in the lymphoma cells, which was confirmed by spectral karyotyping (SKY) and fluorescence in situ hybridization (FISH). Immunohistochemistry revealed that both BCL2 and BCL6 proteins were expressed in the lymphoma cells, whereas only the BCL6 gene, and not the BCL2 gene, was rearranged by Southern blotting. The patient received combination chemotherapy and has been well for 3 years. This is the first reported case showing a three-way translocation involving 2 major lymphoma-specific abnormalities, 3q27 and t(14;18)(q32;q21).
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan. aokano@koto.kpu-m.ac.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Okano
authors.forename: Sonoko
authors.initials: S
authors.lastname: Nakano
authors.forename: Kyoko
authors.initials: K
authors.lastname: Namura
authors.forename: Noriko
authors.initials: N
authors.lastname: Yamada
authors.forename: Ryo
authors.initials: R
authors.lastname: Uchida
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Fuchida
authors.forename: Masashi
authors.initials: M
authors.lastname: Okamoto
authors.forename: Naoya
authors.initials: N
authors.lastname: Ochiai
authors.forename: Chihiro
authors.initials: C
authors.lastname: Shimazaki
mesh_terms: D000328:Adult; D015139:Blotting, Southern; D002883:Chromosomes, Human, Pair 14; D002887:Chromosomes, Human, Pair 18; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008224:Lymphoma, Follicular / Q000235:genetics*; D014178:Translocation, Genetic