Effect of cortisol on aquaporin expression in the esophagus of the European eel, Anguilla anguilla.
Long-term cortisol infusion into freshwater (FW)-adapted eels induced a significant increase in aquaporin-1 (AQP1) mRNA expression within the esophageal epithelium of migratory "silver" eels, but not in nonmigratory, immature "yellow" eels. Cortisol treatment had no significant effect on the mRNA abundance of a second aquaporin-1 isoform, termed AQP1dup, which exhibited a highly variable expression profile among individual members of all fish groups. These results suggest that cortisol, at plasma concentrations similar to that found during FW/seawater (SW) acclimation, induces upregulation in AQP1 expression and thus increases esophageal water permeability during the migration of eels to the SW environment.
Martinez
Anne-Sophie
AS
LBBM, Université de Caen, France. am102@st-andrews.ac.uk
Wilson
Gillian
G
Phillips
Claire
C
Cutler
Christopher
C
Hazon
Neil
N
Cramb
Gordon
G
D000811:Anguilla / Q000378:metabolism*; D000818:Animals; D051398:Aquaporin 1 / Q000096:biosynthesis* / Q000235:genetics; D004524:Eels; D004947:Esophagus / Q000187:drug effects / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D006854:Hydrocortisone / Q000494:pharmacology*
D051398:Aquaporin 1; D006854:Hydrocortisone