Use of highly active antiretroviral therapy in patients with renal insufficiency.
Antiretroviral agents, especially nucleoside reverse transcriptase inhibitors, require significant dosage adjustments in patients who have renal dysfunction and the human immunodeficiency virus (HIV). Some antiretroviral agents and fixed combination preparations are contraindicated in this population. In addition, many preferred antiretroviral regimens may be difficult to administer conveniently in patients with decreased creatinine clearance or in those receiving renal replacement therapies. Some highly active antiretroviral therapy regimens, however, can be used conveniently in patients with HIV and altered renal function.
Duggan
Joan M
JM
Department of Medicine, Medical College of Ohio, Toledo, 43614, USA. jduggan@mco.edu
Sahloff
Eric G
EG
Moudgal
Varsha V
VV
D023241:Antiretroviral Therapy, Highly Active; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D051437:Renal Insufficiency / Q000150:complications*