title: Four cases of simultaneous triple primary cancers of the hypopharynx, esophagus, and stomach.
abstract: OBJECTIVE
  To study the efficacy of intensive chemotherapy for simultaneous triple primary cancers of the hypopharynx, esophagus, and stomach.
  
  
  METHODS
  Retrospective case study.
  
  
  METHODS
  From April 2000 to March 2002, we treated 4 patients who had simultaneous triple primary cancers, including hypopharyngeal, esophageal, and gastric carcinomas. These 4 patients were designated as the objects for analysis, and the treatment modality for simultaneous multiple primary cancer cases was examined.
  
  
  RESULTS
  In 3 of 4 patients, all 3 primary cancers could be controlled by intensive induction chemotherapy and concurrent chemoradiotherapy for hypopharyngeal cancer and by endoscopic mucosal resection or argon plasma coagulation for esophageal and gastric carcinomas.
  
  
  CONCLUSIONS
  In the treatment modality for simultaneous multiple primary cancers, including head and neck cancer, it is important to select intensive systemic chemotherapy and decide the order for treating each primary lesion in consideration of each patient's curability and prognosis.
authors.affiliation: Department of Otolaryngology, Yokohama City University Medical Center, Fujisawa City Hospital, 2-6-1 Fujisawa, Fujisawa City, Kanagawa 251-8550, Japan. ikeda.y@jcom.home.ne.jp
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tsukuda
authors.forename: Junichi
authors.initials: J
authors.lastname: Ishitoya
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Arai
authors.forename: Hideki
authors.initials: H
authors.lastname: Matsuda
authors.forename: Hideaki
authors.initials: H
authors.lastname: Katori
authors.forename: Takahide
authors.initials: T
authors.lastname: Taguchi
authors.forename: Takafumi
authors.initials: T
authors.lastname: Yoshida
authors.forename: Machiko
authors.initials: M
authors.lastname: Ono
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Sakuma
authors.forename: Mizuho
authors.initials: M
authors.lastname: Yagisawa
authors.forename: Norifumi
authors.initials: N
authors.lastname: Saito
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy*; D005753:Gastric Mucosa; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D011379:Prognosis; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000601:surgery