title: [Pathophysiology of acne].
abstract: Acne is a disease that develops in pilosebaceous follicles. Acne was long considered was an infectious disease related to Propionibac-terium acnes, but studies show that the production of inflammatory substances in situ was much more important to the action of this bacterium than was simple infection. It was once thought that only the androgens could stimulate the seba-ceous gland, but today we know that neuromediators can also stimulate sebum production. This finding provides physiological support to the clinical observation that stress can induce acne.
authors.affiliation: Service de dermatologie, Hôtel Dieu, place Alexis Ricordeau, 44093 Nantes Cedex 01. brigitte.dreno@wanadoo.fr
authors.forename: Brigitte
authors.initials: B
authors.lastname: Dréno
mesh_terms: D000152:Acne Vulgaris / Q000503:physiopathology*; D000728:Androgens / Q000494:pharmacology*; D006801:Humans; D007239:Infections; D007249:Inflammation; D012627:Sebaceous Glands / Q000502:physiology*; D013315:Stress, Psychological
chemical_list: D000728:Androgens