title: [Effect of polymer concentration on rheological properties of Carbopol 980 hydrogels containing trimecainium chloride].
abstract: Rheological properties exert influence on the manufacturing processes, stability and usability of a dosage form as well as the biological availability of an active ingredient. The present paper examines the effect of Carbopol 980 concentration on rheological properties of hydrogels with and without trimecainium chloride for a period of 2, 7, and 14 days after their preparation. On the basis of an evaluation of the changes in structural viscosity in dependence on the period of measurement, it has been concluded that for formulation of trimecainium chloride to a dermal dosage form, Carbopol 980 concentrations of 0.5 and 1.2 % are suitable.
authors.affiliation: Farmaceutická fakulta Univerzity Komenského v Bratislave, Katedra galenickej farmácie. margareta@centrum.sk
authors.forename: M
authors.initials: M
authors.lastname: Subová
authors.forename: Z
authors.initials: Z
authors.lastname: Vitková
authors.forename: E
authors.initials: E
authors.lastname: Cirbusová
authors.forename: I
authors.initials: I
authors.lastname: Erös
authors.forename: M
authors.initials: M
authors.lastname: Kónya
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000779:Anesthetics, Local; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D020100:Hydrogels / Q000737:chemistry*; D012212:Rheology; D014288:Trimecaine
chemical_list: D000180:Acrylic Resins; D000779:Anesthetics, Local; D020100:Hydrogels; C479038:carbomer; D014288:Trimecaine