Adult Henoch-Schönlein purpura with severe abdominal pain treated with dapsone and factor XIII concentrate.
We describe an adult patient with Henoch-Schönlein purpura who had arthralgia, severe abdominal pain, and low plasma factor XIII activity. Corticosteroids were not used because of his history of multidrug-resistant pulmonary tuberculosis. Dapsone had no immediate effect on his abdominal pain, but appeared to have some effect on the purpura and arthralgia. Marked improvement of the abdominal pain was observed immediately after the administration of factor XIII concentrate. Factor XIII concentrate may be useful for alleviating abdominal pain in Henoch-Schönlein purpura patients when corticosteroids are contraindicated
Shimomura
Naoko
N
Division of Dermatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Niigata 951-8510, Japan.
Kawai
Kazuhiro
K
Watanabe
Shiro
S
Katsuumi
Kaoru
K
Ito
Masaaki
M
D015746:Abdominal Pain / Q000209:etiology; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D003622:Dapsone / Q000008:administration & dosage / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005176:Factor XIII / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D008297:Male
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003622:Dapsone; D005176:Factor XIII