title: New insights into the molecular biology of the glomerular filtration barrier and associated disease.
abstract: The glomerular filtration barrier of the kidney can no longer be considered as an inert and adynamic structure, viewed by electron microscopy. Molecular biology, medical genetics and protein chemistry have enabled us to further understand the complex structure and function of this highly specialized barrier of the kidney. Minor aberrations of physiology can lead to fatal disease. Recent advances in the understanding of the physiology of endothelial cells, glomerular epithelial cells and the glomerular basement membrane and its components, and how these relate to disease, will be considered systematically.
authors.affiliation: Austin Research Institute, Department of Nephrology, Austin Health, Melbourne, Victoria, Australia. Vicki.Levidiotis@austin.org.au
authors.forename: Vicki
authors.initials: V
authors.lastname: Levidiotis
authors.forename: David A
authors.initials: DA
authors.lastname: Power
mesh_terms: D000818:Animals; D001485:Basement Membrane / Q000473:pathology / Q000502:physiology; D024141:Collagen Type IV / Q000235:genetics; D006801:Humans; D016023:Integrins / Q000235:genetics; D007674:Kidney Diseases / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology*; D007678:Kidney Glomerulus / Q000473:pathology / Q000502:physiology*; D007797:Laminin / Q000235:genetics; D011509:Proteoglycans / Q000235:genetics
chemical_list: D024141:Collagen Type IV; D016023:Integrins; D007797:Laminin; D011509:Proteoglycans