Hematuria in thin basement membrane nephropathy.
Thin basement membrane nephropathy (TBMN) often is diagnosed clinically when there is persistent dysmorphic or glomerular hematuria, but minimal proteinuria, normal kidney function, and no other obvious cause. This study investigated hematuria in patients with TBMN. A total of 112 patients with biopsy examination-proven TBMN were studied. All had hematuria at the time of presentation, with a mean urinary red blood cell (RBC) count of 256 +/- 250 x 10 3 /mL. Seventy-five (67%) patients attended for review over a median of 48 months (range, 3-120 mo) and provided a total of 485 urine specimens. Twenty-one patients (28%) had no hematuria by phase-contrast microscopy on at least 1 occasion. These corresponded to 32 urine specimens (7% of total). Of the 21 patients, the most recent urinary RBC counts were within the normal range in 11 (52%), but hematuria had recurred in the other 10 (48%). Hematuria is persistent in most patients with TBMN, but occasionally it resolves or is intermittent.
Packham
David K
DK
Department of Medicine, University of Melbourne, Melbourne, Australia. dmpackham@netspace.net.au
Perkovic
Vlado
V
Savige
Judy
J
Broome
Megan R A
MR
D003937:Diagnosis, Differential; D004906:Erythrocyte Count; D005260:Female; D005500:Follow-Up Studies; D015433:Glomerulonephritis, Membranous / Q000150:complications* / Q000473:pathology / Q000652:urine; D006417:Hematuria / Q000209:etiology* / Q000473:pathology / Q000652:urine; D006801:Humans; D007678:Kidney Glomerulus / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008856:Microscopy, Fluorescence; D008858:Microscopy, Phase-Contrast; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016482:Urinalysis