title: Severe non-pneumonic necrotising infections in children caused by Panton-Valentine leukocidin producing Staphylococcus aureus strains.
abstract: Two cases of infection with Panton-Valentine Leukocidin (PVL) producing strains of Staphylococcus aureus are reported. A 15-year-old insulin dependent diabetic developed toxic shock syndrome and an abscess in the deep tissue around his left hip. A 34-day-old infant presented with a right orbital cellulitis with an intra-orbital collection and septicaemia. In both cases PVL-producing strains of Staphylococcus aureus were isolated. Both surgery and prolonged antibiotic combination regimens were required to eradicate the infection. The cases reported here demonstrate the wide range of clinical presentations seen with PVL producing strains, which have so far been mainly associated with furuncles and necrotising pneumonia.
authors.affiliation: Department of Paediatrics, Sunderland Royal Hospital, Kayll Rd, Sunderland SR4 7TP, UK. bernd.reichert@doctors.org.uk
authors.forename: B
authors.initials: B
authors.lastname: Reichert
authors.forename: G
authors.initials: G
authors.lastname: Birrell
authors.forename: G
authors.initials: G
authors.lastname: Bignardi
mesh_terms: D000038:Abscess / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001427:Bacterial Toxins; D002481:Cellulitis / Q000175:diagnosis / Q000382:microbiology; D005098:Exotoxins; D006615:Hip / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007956:Leukocidins / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D008297:Male; D009336:Necrosis / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy; D009916:Orbital Diseases / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy; D018461:Soft Tissue Infections / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D013203:Staphylococcal Infections / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy; D013211:Staphylococcus aureus / Q000302:isolation & purification / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin