Effectiveness and toxicity of single-fraction radiotherapy with 1 x 8 Gy for metastatic spinal cord compression.
Toxicity and functional outcome were evaluated in 199 MSCC-patients irradiated with 1 x 8 Gy. Motor function improved in 54/199 patients (27%). Patients who regained walking ability were 20/78 (26%). Long-term-survivors (> or =12 months) who needed re-irradiation for in-field-recurrence were 19/65 (29%). Acute toxicity was mild, late toxicity not observed. A randomised trial comparing single-fraction RT to multi-fraction RT is mandatory.
Rades
Dirk
D
Department of Radiation Oncology, University Hospital Hamburg-Eppendorf, D-20246 Hamburg, Germany. rades.dirk@gmx.net
Stalpers
Lukas J A
LJ
Hulshof
Maarten C C M
MC
Zschenker
Oliver
O
Alberti
Winfried
W
Koning
Caro C E
CC
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D011832:Radiation Injuries; D013117:Spinal Cord Compression / Q000209:etiology* / Q000532:radiotherapy*; D013120:Spinal Cord Neoplasms / Q000150:complications / Q000532:radiotherapy* / Q000556:secondary*; D016896:Treatment Outcome