title: [Severe Streptococcus agalactiae infection of the diabetic foot. A deleterious role of Streptococcus agalactiae?].
abstract: BACKGROUND
  Screening strategies among pregnant women have decreased the incidence of group B Streptococcus, which causes severe neonatal infections. The incidence of these infections has increased among diabetic patients, however.
  
  
  OBJECTIVE
  To specify the characteristics of diabetic foot infections in which surgical samples have isolated one or several germs including group B Streptococcus, study its risk factors and determine its course.
  
  
  METHODS
  We retrospectively evaluated the records of all patients admitted to the University Hospital of Geneva from January 1999 through October 2004, with diagnoses of severe foot infection (+/- osteomyelitis) documented during surgery.
  
  
  RESULTS
  Twenty-five severe diabetic foot infections were identified, 21 with osteomyelitis. The most common risk factors were age older than 60 years (n=10), chronic renal failure (n=7), severe arteriopathy (n=6), and immune depression (n=2). Most lesions were classified as grade 3 or 4 of Wagner's classification. 80% of the surgical samples were polymicrobial. Blood cultures were positive in 4 patients, one in septic shock. Half the patients (n=13) underwent amputation, despite initially appropriate antibiotic treatment. No patients died but 3 relapsed.
  
  
  CONCLUSIONS
  Group B streptococcal foot infections often occur in fragile patients with immune depression or severe arterial disease. Despite intensive antibiotic therapy and adequate debridement, amputation is often required in diabetic patients because of severe damage to the tissue and poor vascularization.
authors.affiliation: Département de médecine, Hôpital universitaire cantonal, Genève, Suisse.
authors.forename: Catherine Altrichter
authors.initials: CA
authors.lastname: Loan
authors.forename: Laurence
authors.initials: L
authors.lastname: Legout
authors.forename: Mathieu
authors.initials: M
authors.lastname: Assal
authors.forename: Peter
authors.initials: P
authors.lastname: Rohner
authors.forename: Pierre
authors.initials: P
authors.lastname: Hoffmeyer
authors.forename: Louis
authors.initials: L
authors.lastname: Bernard
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D017719:Diabetic Foot / Q000150:complications* / Q000382:microbiology*; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D051437:Renal Insufficiency; D012189:Retrospective Studies; D012307:Risk Factors; D013290:Streptococcal Infections / Q000473:pathology* / Q000601:surgery; D013292:Streptococcus agalactiae / Q000472:pathogenicity*