Suggestive evidence for association of D2S2188 marker (2q31.1) with autism in 143 Sicilian (Italian) TRIO families.
We have screened 143 Sicilian (Italian) families with one autistic child to verify, by a linkage disequilibrium approach, the involvement of the 2q31.1 region in the cause of the disease in these families. Our study design includes the use of intrafamilial association to prevent a population stratification bias and ethnic homogeneity of the sample. The results of our analysis provided suggestive evidence of the occurrence of transmission disequilibrium between autism and the D2S2188 polymorphism in Sicilian TRIO families, a finding which provides further and independent support to the hypothesis of the existence of a susceptibility gene (or genes) for autism on chromosome 2q.
Romano
Valentino
V
Dipartimento di Biopatologia e Metodologie Biomediche, Università degli Studi di Palermo, Palermo eIRCCS Oasi Maria SS, Troina (EN), Italy. vromano@unipa.it
Calì
Francesco
F
Seidita
Gregorio
G
Mirisola
Mario
M
D'Anna
Rosalba P
RP
Gambino
Giovanna
G
Schinocca
Pietro
P
Romano
Salvatore
S
Ayala
Giovanni F
GF
Canziani
Fabio
F
De Leo
Giacomo
G
Elia
Maurizio
M
D001321:Autistic Disorder / Q000453:epidemiology / Q000235:genetics*; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D005190:Family; D005819:Genetic Markers; D006801:Humans; D011110:Polymorphism, Genetic; D012802:Sicily / Q000453:epidemiology
D005819:Genetic Markers