How might cohesin hold sister chromatids together?
The sister chromatid cohesion essential for the bi-orientation of chromosomes on mitotic spindles depends on a multi-subunit complex called cohesin. This paper reviews the evidence that cohesin is directly responsible for holding sister DNAs together and considers how it might perform this function in the light of recent data on its structure.
Nasmyth
Kim
K
IMP (Research Institute of Molecular Pathology), Dr Bohr-Gasse 7, A-1030 Vienna, Austria. knasmyth@imp.univie.ac.at
D000255:Adenosine Triphosphate / Q000378:metabolism; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000378:metabolism; D002842:Chromatids / Q000502:physiology*; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D005656:Fungal Proteins; D008954:Models, Biological; D009687:Nuclear Proteins / Q000378:metabolism* / Q000502:physiology*; D011487:Protein Conformation; D008941:Spindle Apparatus / Q000378:metabolism; D000097722:Cohesins; D000098550:Structural Maintenance of Chromosome Protein 1
D000255:Adenosine Triphosphate; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D005656:Fungal Proteins; D009687:Nuclear Proteins; D000097722:Cohesins; D000098550:Structural Maintenance of Chromosome Protein 1