Olfactory bulb mitral cell dendritic pruning abnormalities in a mouse model of the Fragile-X mental retardation syndrome: further support for FMRP's involvement in dendritic development.
The Fragile-X mental retardation syndrome is the leading form of inherited mental retardation. Dendritic analysis in a mouse model (FraX) found abnormal pruning in somatosensory cortex. To further characterize dendritic abnormalities and assess their occurrence in other brain regions, we examined mitral cells in FraX mice olfactory bulbs. FraX mice exhibited dendritic abnormalities consistent with somatosensory cortex, suggesting that deficient pruning is found in multiple brain regions.
Galvez
Roberto
R
Neuroscience Program, University of Illinois, Urbana, IL 61801, USA.
Smith
Rebecca Lynn
RL
Greenough
William T
WT
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D003712:Dendrites / Q000473:pathology*; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000502:physiology; D051860:Fragile X Messenger Ribonucleoprotein 1; D005600:Fragile X Syndrome / Q000473:pathology* / Q000503:physiopathology; D020868:Gene Silencing / Q000502:physiology; D051379:Mice; D008818:Mice, Neurologic Mutants; D008822:Mice, Transgenic; D009419:Nerve Tissue Proteins / Q000172:deficiency* / Q000235:genetics; D009421:Nervous System Malformations / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D000857:Olfaction Disorders / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D009830:Olfactory Bulb / Q000002:abnormalities* / Q000473:pathology* / Q000503:physiopathology; D009833:Olfactory Pathways / Q000002:abnormalities / Q000473:pathology / Q000503:physiopathology; D016601:RNA-Binding Proteins / Q000235:genetics; D012903:Smell / Q000235:genetics; D013003:Somatosensory Cortex / Q000002:abnormalities / Q000473:pathology / Q000503:physiopathology
D051860:Fragile X Messenger Ribonucleoprotein 1; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins; C497684:Fmr1 protein, mouse