title: End-stage cardiac failure caused by isolated ventricular non-compaction: cardiac transplantation in a 5-year-old boy.
abstract: Isolated ventricular non-compaction (IVNC) is a rare congenital cardiomyopathy characterized by arrest in endomyocardial morphogenesis. Presenting features in children include systolic and diastolic ventricular dysfunction, cardiac arrhythmias, and thromboembolism. End-stage cardiac failure necessitating cardiac transplantation is described in adults. We report the unique case of a 5-year-old boy with IVNC and end-stage heart failure who underwent cardiac transplantation. Diagnostic echocardiographic features, gross cardiac morphology, and histopathologic findings are illustrated.
authors.affiliation: Department of Paediatric Cardiology Freeman Hospital, Newcastle upon Tyne, United Kingdom.
authors.forename: Melanie
authors.initials: M
authors.lastname: Vogel
authors.forename: Milind
authors.initials: M
authors.lastname: Chaudhari
authors.forename: Doris
authors.initials: D
authors.lastname: Rassl
authors.forename: Lara
authors.initials: L
authors.lastname: Mair
authors.forename: Asif
authors.initials: A
authors.lastname: Hasan
mesh_terms: D009202:Cardiomyopathies / Q000151:congenital* / Q000601:surgery*; D002675:Child, Preschool; D004699:Endocardium / Q000002:abnormalities / Q000196:embryology; D006321:Heart / Q000196:embryology; D006330:Heart Defects, Congenital / Q000601:surgery*; D006333:Heart Failure / Q000209:etiology / Q000601:surgery; D016027:Heart Transplantation; D006801:Humans; D008297:Male; D009206:Myocardium