title: [Correlation of endothelin A receptor expression to prognosis of nasopharyngeal carcinoma].
abstract: OBJECTIVE
  Endothelin A receptor (ET(A)R) activation contributes to tumor growth and metastasis, including cell proliferation, cell death, angiogenesis, and metastatic spread. In this study, we evaluated correlation of ET(A)R expression to clinical features of nasopharyngeal carcinoma (NPC), and explored its correlation to prognosis.
  
  
  METHODS
  Expression of ET(A)R in 153 specimens of NPC was detected by SABC immunohistochemistry.
  
  
  RESULTS
  Positive rate of ET(A)R was 73.9% in the 153 NPC specimens. No correlation was found between ET(A)R expression and gender, age, T stage, N stage, and TNM stage of the patients. The 3-year overall survival rate, relapse-free survival rate, and distant metastasis-free survival rate were significantly higher in ET(A)R-negative patients than in ET(AR-positive patients (87.5% vs. 73.2%, P = 0.029; 80.0% vs. 57.3%, P = 0.009; and 89.9% vs. 70.4%, P = 0.012), except for local relapse-free survival rate (86.9% vs. 80.2%, P = 0.228). Cox multivariate analysis showed that ET(A)R expression, gender, age, T stage, and N stage were independent prognostic factors, which affected overall survival, relapse-free survival, and distant metastasis.
  
  
  CONCLUSIONS
  ET(A)R expression is an important distant metastasis-related risk factor for patients with NPC; its overexpression indicates poor prognosis.
authors.affiliation: Department of Nasopharyngeal Carcinoma, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P.R.China.
authors.forename: Hai-Qiang
authors.initials: HQ
authors.lastname: Mai
authors.forename: Zong-Yuan
authors.initials: ZY
authors.lastname: Zeng
authors.forename: Hui-Zhong
authors.initials: HZ
authors.lastname: Zhang
authors.forename: Jing-Hui
authors.initials: JH
authors.lastname: Hou
authors.forename: Hao-Yuan
authors.initials: HY
authors.lastname: Mo
authors.forename: Xiang
authors.initials: X
authors.lastname: Guo
authors.forename: Hua-Qing
authors.initials: HQ
authors.lastname: Min
authors.forename: Ming-Huang
authors.initials: MH
authors.lastname: Hong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D044022:Receptor, Endothelin A / Q000378:metabolism*; D015996:Survival Rate
chemical_list: D044022:Receptor, Endothelin A