title: Investigations on 5-fluorouracil solid lipid nanoparticles (SLN) prepared by hot homogenization.
abstract: The purpose of this study was to investigate the effect of different formulation factors on the properties of solid lipid nanoparticles (SLN) prepared by a hot homogenization method. Using the particle size, physical stability constant (K(e)) and zeta-potential as standards, the stability of SLNs was investigated as a function of phospholipid and poloxamer contents. It was demonstrated that the content of phospholipid had a significant influence on the zeta-potential, which increased considerably with increasing phospholipid content. However, the particle size increased remarkably when the phospholipid content was as high as 1.5% due to the increased viscosity. Poloxamer 188 exhibited no remarkable influence on particle size when the concentration was as low as 1.0%. The influence of the phospholipid and poloxamer content on the embedding ratios of drug substances was further studied using 5-fluorouracil (5-Fu) as a model drug. It was shown that the embedding ratio increased considerably with phospholipid content and independent of poloxamer content, implying that 5-Fu was incorporated into the phospholipid bilayer membrane.
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road 103, 110016 Shenyang, China. maoshirui@vip.sina.com
authors.forename: Shirui
authors.initials: S
authors.lastname: Mao
authors.forename: Pu
authors.initials: P
authors.lastname: Wang
authors.forename: Dianzhou
authors.initials: D
authors.lastname: Bi
mesh_terms: D000465:Algorithms; D000963:Antimetabolites / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D005079:Excipients; D005472:Fluorouracil / Q000737:chemistry*; D008055:Lipids; D008863:Microspheres; D010316:Particle Size; D010743:Phospholipids / Q000737:chemistry; D020442:Poloxamer / Q000737:chemistry; D013229:Stearic Acids / Q000737:chemistry
chemical_list: D000963:Antimetabolites; D005079:Excipients; D008055:Lipids; D010743:Phospholipids; D013229:Stearic Acids; D020442:Poloxamer; D005472:Fluorouracil