title: [The choice of surgical therapy in adenocarcinoma of the cardia].
abstract: OBJECTIVE
  From 1996 the adenocarcinoma of the esophago-gastric junction (AEG) is divided into 3 types according to Siewert's classification. For AEG type I and III the surgical treatment is codified, while for type II is still controversial. The aim of our study is to understand what is the better surgical treatment for AEG type II.
  
  
  METHODS
  From 1990 to 2002 we have performed 111 resections for adenocarcinoma of the cardia: 25 for AEG type I (all esophago-gastric resection), 39 for type II (22 esophago-gastric resection, 17 extended total gastrectomy with esophageal resection) and 47 for type III (8 esophago-gastric resection, 39 extended total gastrectomy with esophageal resection).
  
  
  RESULTS
  The morbidity and mortality rates are 17 and 5.4%, without significant difference between the different surgical treatment (p>0.01). The 5 year survival rate is 35%. Significant prognostic factors are the staging TNM (p=0.002) and principally the presence of metastatic lymph nodes (p=0.001). For AEG type II any significant difference in survival is associated with surgical strategy, also in early stage (p>0.01).
  
  
  CONCLUSIONS
  According to the results of our study and those of the other authors, who have showed that a 10 cm distance of the neoplasm by the gastric side and the esophageal one could assure oncologic radicality and also that metastatic lymph nodes below pylorus and near greater curvature are uncommon, we can consider esophago-gastric resection for AEG II a speedy, safe and oncologically correct surgical treatment.
authors.affiliation: III Unità di Chirurgia Generale, Dipartimento di Fisiopatologia Clinica, Ospedale San Giovanni Battista Molinette, Università degli Studi di Torino, via Genova 3, 10126 Turin, Italy. soleriod@libero.it
authors.forename: D
authors.initials: D
authors.lastname: Solerio
authors.forename: M
authors.initials: M
authors.lastname: Camandona
authors.forename: G
authors.initials: G
authors.lastname: Gasparri
authors.forename: P A
authors.initials: PA
authors.lastname: Casalegno
authors.forename: E
authors.initials: E
authors.lastname: Raggio
authors.forename: M
authors.initials: M
authors.lastname: Dei Poli
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical / Q000379:methods; D002299:Cardia / Q000473:pathology / Q000601:surgery; D004938:Esophageal Neoplasms / Q000473:pathology / Q000601:surgery*; D004943:Esophagogastric Junction / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*; D016019:Survival Analysis; D016896:Treatment Outcome