title: Myocardium utilizes more oxygen and glucose during tepid blood cardioplegic infusion in arrested heart.
abstract: The aims of this study were to evaluate myocardial metabolic activity during tepid blood cardioplegic infusion in the arrested heart in comparison with cold blood cardioplegia and to assess the early clinical outcomes of these patients. Thirty patients undergoing first elective coronary artery bypass grafting surgery were included and randomized to two groups (T for tepid and C for cold), 15 patients in each. Myocardial protection was similar in both groups except for the reinfusion of blood cardioplegia, which was 6 degrees C in group C and 28 degrees C in group T (same temperature as the body perfusion). The route of cardioplegic reinfusion was antegrade during the first reinfusion and retrograde during the second reinfusion. In order to assess myocardial metabolic activity, myocardial oxygen consumption (MVO2), myocardial glucose uptake, and myocardial lactate and acid production were all calculated. Arterial and coronary venous blood samples were obtained from the aortic root cannula and coronary sinus. During cardioplegic re-infusions in the ischemic period, the calculated values of myocardial oxygen extraction, oxygen consumption, and glucose uptake were higher in group T than in group C (P < 0.05). This difference was observed during both antegrade and retrograde delivery of cardioplegic solution. Myocardial lactate production was greater in group C than in group T during cardioplegic reinfusion, both antegradely and retrogradely (P < 0.05). In all patients, cardiopulmonary bypass was terminated in the first attempt. The clinical outcome was similar in both groups. The results of this study indicate that globally ischemic myocardium is able to utilize more oxygen and glucose during cardioplegic re-infusions at a tepid temperature in comparison to cold. In addition, the data showed evidence of less myocardial injury and better left ventricular function throughout the critical period of recovery from global ischemia for the heart protected by tepid cardioplegia.
authors.affiliation: Depertment of Cardiovascular Surgery, Adnan Menderes University, Aydin, Turkey.
authors.forename: Muharrem I
authors.initials: MI
authors.lastname: Badak
authors.forename: Ugur
authors.initials: U
authors.lastname: Gurcun
authors.forename: Berent
authors.initials: B
authors.lastname: Discigil
authors.forename: Mehmet
authors.initials: M
authors.lastname: Boga
authors.forename: Erdem A
authors.initials: EA
authors.lastname: Ozkisacik
authors.forename: Emin A
authors.initials: EA
authors.lastname: Alayunt
mesh_terms: D000368:Aged; D001769:Blood; D002315:Cardiopulmonary Bypass; D003080:Cold Temperature; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000503:physiopathology / Q000601:surgery; D017558:Elective Surgical Procedures; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006324:Heart Arrest, Induced / Q000379:methods*; D006439:Hemodynamics; D006801:Humans; D007773:Lactates / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption; D011446:Prospective Studies; D016277:Ventricular Function, Left
chemical_list: D007773:Lactates; D005947:Glucose