title: Differential expression of cytokines in the brain and serum during endotoxin tolerance.
abstract: Using short- and long-course lipopolysaccharide (LPS) treatment regimens to induce endotoxin tolerance in rats, we compared TNF-alpha, IL-1beta, and IL-6 expression in the brain and serum following a LPS challenge. Serum corticosterone was also examined to evaluate the function of the hypothalamic-pituitary-adrenal (HPA) axis. We found that, during endotoxin tolerance, LPS-induced cytokine expression still occurred in the brain even when cytokines in the periphery were no longer induced, and that this differential cytokine expression may be mediated by corticosterone, a stress hormone and an anti-inflammatory agent.
authors.affiliation: Department of Biology, Seton Hall University, 400 South Orange Avenue, South Orange, NJ 07079, USA.
authors.forename: Ru
authors.initials: R
authors.lastname: Chen
authors.forename: Heping
authors.initials: H
authors.lastname: Zhou
authors.forename: Jose
authors.initials: J
authors.lastname: Beltran
authors.forename: Lorenc
authors.initials: L
authors.lastname: Malellari
authors.forename: Sulie L
authors.initials: SL
authors.lastname: Chang
mesh_terms: D000818:Animals; D001921:Brain / Q000276:immunology / Q000378:metabolism*; D016207:Cytokines / Q000096:biosynthesis* / Q000097:blood* / Q000235:genetics; D004334:Drug Administration Schedule; D005786:Gene Expression Regulation / Q000276:immunology; D007108:Immune Tolerance / Q000276:immunology*; D008070:Lipopolysaccharides / Q000633:toxicity*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D016207:Cytokines; D008070:Lipopolysaccharides