Plasma cell granuloma of the maxillary sinus: a case report and literature review.
BACKGROUND
Plasma cell granulomas are rare and heterogeneous tumor-like lesions of mixed inflammatory cell infiltrates of unknown etiology. Although they have the potential to occur in sites throughout the body, their occurrence in the paranasal sinuses and nasal cavity is uncommon and often associated with unique clinical characteristics and natural history.


METHODS
We present a case of an aggressive plasma cell granuloma of the maxillary sinus and a review of the literature (28 cases).


RESULTS
The patient was treated with definitive radiotherapy (45 Gy in 25 fractions) and experienced a local recurrence 2 years later. The lesion initially responded to corticosteroids and then progressed. Resection was performed and was followed by another recurrence. The patient was treated with radiosurgery and is disease free 8 years after initial treatment.


CONCLUSIONS
Review of the literature indicates that the optimal first line of treatment is high-dose corticosteroids. Surgery is indicated if the lesion fails to respond. Radiotherapy is indicated if complete resection is not feasible.
Newlin
Heather E
HE
Department of Radiation Oncology, University of Florida College of Medicine, University of Florida Health Science Center, P. O. Box 100385, Gainesville, FL 32610-0385, USA.
Werning
John W
JW
Mendenhall
William M
WM
D000305:Adrenal Cortex Hormones / Q000528:radiation effects; D000368:Aged; D001706:Biopsy; D018572:Disease-Free Survival; D005260:Female; D006104:Granuloma, Plasma Cell / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D008444:Maxillary Sinus Neoplasms / Q000175:diagnosis / Q000628:therapy*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000628:therapy*; D016634:Radiosurgery; D018714:Radiotherapy, Adjuvant; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones