[The expression of Fas and bcl-2 in hamster buccal carcinogenesis].
OBJECTIVE
To study the expression of Fas and bcl-2 in oral carcinogenesis.


METHODS
Using immunohistochemical method,we studied the expression of Fas and bcl-2 in DMBA induced hamster baccal carcinogenesis including negative control (14), hyperkeratosis (7), epithelial dysplasia (mild 12, moderate 7, severe 9), oral squamous cell carcinoma(OSCC) (25). Non-parametric test was used for statistical analysis.


RESULTS
Fas was expressed in negative control consistently except stratum basale,and there was down-regulation in oral dysplasia and OSCC (chi(2)=45.576, P<0.05).bcl-2 was rarely expressed in negative control, and there was up-regulation in oral dysplasia and OSCC (chi(2)=19.433, P<0.05).


CONCLUSIONS
Fas and bcl-2 may play an important role in inhibiting apoptosis coordinately, resulting in the imbalance of cell proliferation and apoptosis, which may contribute to oral carcinogenesis.
Wang
Xia
X
Department of Oral Pathology, School of Stomatology, Shandong University, Shandong Province, China.
Sun
Shan-zhen
SZ
Zhang
Xiao-ying
XY
Ma
Bo-long
BL
D000818:Animals; D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000378:metabolism; D063646:Carcinogenesis; D002294:Carcinoma, Squamous Cell / Q000378:metabolism; D049109:Cell Proliferation; D006224:Cricetinae; D053222:Fas Ligand Protein / Q000235:genetics* / Q000378:metabolism; D019254:Genes, bcl-2; D009062:Mouth Neoplasms / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics* / Q000378:metabolism
D014408:Biomarkers, Tumor; D053222:Fas Ligand Protein; D019253:Proto-Oncogene Proteins c-bcl-2