Temporal regulation of planar cell polarity: insights from the Drosophila eye.
In this issue of Cell, identify a first regulatory link between planar cell polarity (PCP) signaling and apical-basal polarity. The authors propose that a component of the apical Crumbs complex regulates the phosphorylation of the Frizzled (Fz) PCP receptor, thus modulating PCP in the Drosophila eye.
Schweisguth
François
F
Ecole Normale Supérieure, CNRS UMR8542, 46 rue d'Ulm, 75230 Paris Cedex 05, France. Electronic address: schweisg@wotan.ens.fr.
D000818:Animals; D002462:Cell Membrane / Q000235:genetics / Q000378:metabolism; D016764:Cell Polarity / Q000502:physiology; D004331:Drosophila melanogaster; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism; D005123:Eye / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D051157:Frizzled Receptors; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled; D017981:Receptors, Neurotransmitter / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D013997:Time Factors
C064360:crb protein, Drosophila; D029721:Drosophila Proteins; D051157:Frizzled Receptors; C101703:fz2 protein, Drosophila; D008565:Membrane Proteins; D043562:Receptors, G-Protein-Coupled; D017981:Receptors, Neurotransmitter