title: Risk factors, echocardiographic patterns, and outcomes in patients with acute ventricular septal rupture during myocardial infarction.
abstract: Ventricular septal rupture (VSR), which can complicate an acute myocardial infarction (MI), carries a high mortality rate. Because precordial and transesophageal echocardiography can identify the type of rupture and assess right ventricular (RV) function at the patient's bedside, we examined the prognostic significance of echocardiographic patterns in postinfarct VSR by postulating that complex rupture and RV involvement carry a worse prognosis. Seventeen patients (10 men; mean age 66 years) who had confirmed postinfarct VSR underwent precordial and transesophageal echocardiography followed by coronary angiography. Serial 12-lead and right precordial leads were also available. Type of septal rupture was classified as simple or complex based on autopsy-proved echocardiographic criteria. Three patients had inferior wall MI and 14 had anterior wall MI. ST-segment elevation persisted >72 hours in all 3 patients who had inferior wall MI and in 12 who had anterior wall MI. Segmental wall motion abnormalities helped in detecting the left ventricular entry site, and use of unconventional views superimposed with color flow Doppler provided the RV exit site. RV function was better appreciated with transesophageal echocardiography. Two patients who had inferior wall MI and 7 who had anterior wall MI had complex ruptures. All 3 patients who had inferior wall MI and 7 who had anterior wall MI had electrocardiographic and echocardiographic evidence of RV involvement. Mortality rate was higher in patients who had complex rupture (78% vs 38%, p <0.001) and in those who had RV extension (71% vs 29%, p <0.001). In conclusion, persistent ST elevation is a common finding in patients who have postinfarct VSR. Complex VSR and RV involvement are significant determinants of clinical outcome.
authors.affiliation: Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Jesús
authors.initials: J
authors.lastname: Vargas-Barrón
authors.forename: Marjorie
authors.initials: M
authors.lastname: Molina-Carrión
authors.forename: Angel
authors.initials: A
authors.lastname: Romero-Cárdenas
authors.forename: Francisco-Javier
authors.initials: FJ
authors.lastname: Roldán
authors.forename: Gustavo A
authors.initials: GA
authors.lastname: Medrano
authors.forename: Carmen
authors.initials: C
authors.lastname: Avila-Casado
authors.forename: Marco A
authors.initials: MA
authors.lastname: Martínez-Ríos
authors.forename: Eulo
authors.initials: E
authors.lastname: Lupi-Herrera
authors.forename: Miguel
authors.initials: M
authors.lastname: Zabalgoitia
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D017548:Echocardiography, Transesophageal; D004562:Electrocardiography; D005260:Female; D006784:Hospitals, Teaching; D006801:Humans; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000000981:diagnostic imaging; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D013781:Texas / Q000453:epidemiology; D018658:Ventricular Septal Rupture / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality / Q000473:pathology