Emerging roles of TRPM6/TRPM7 channel kinase signal transduction complexes.
Investigations into Drosophila mutants with impaired vision due to mutations in the transient receptor potential gene (trp) initiated a systematic search for TRP homologs in other species, finally leading to the discovery of a whole new family of plasma membrane cation channels involved in multiple physiological processes. Among the recently discovered TRP cation channels two homologous proteins, TRPM6 and TRPM7, display unique domain compositions and biophysical properties. These remarkable genes are vital for Mg(2+) homeostasis in vertebrates and, if disrupted, lead to cell death or human disease.
Chubanov
V
V
Institut für Pharmakologie und Toxikologie, Philipps-Universität-Marburg, Karl-von-Frisch Strasse 1, 35033, Marburg, Germany.
Mederos y Schnitzler
M
M
Wäring
J
J
Plank
A
A
Gudermann
T
T
D000818:Animals; D001483:Base Sequence; D006801:Humans; D008274:Magnesium / Q000378:metabolism*; D051379:Mice; D008969:Molecular Sequence Data; D010770:Phosphotransferases / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases; D015398:Signal Transduction / Q000502:physiology*; D050053:TRPM Cation Channels / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
D050053:TRPM Cation Channels; C459082:TRPM6 protein, human; D010770:Phosphotransferases; C421903:Trpm7 protein, mouse; D017346:Protein Serine-Threonine Kinases; C486583:TRPM7 protein, human; D008274:Magnesium