Increased serum neopterin levels in adults with Down syndrome.
We quantitated serum neopterin levels in Down syndrome (DS), normal controls, Alzheimer's disease, multiple sclerosis and other neurological diseases. We then analyzed the relationships with age, sex, apolipoprotein E (Apo E) phenotype, and amyloid beta protein 1-40 (Abeta40) and 1-42 (Abeta42) levels. Neopterin levels were higher in DS than all other groups. Levels in young DS (< 40 years of age) and old DS (> 41 years) were similar. There was no significant correlation between neopterin levels and age, sex, Apo E phenotype, and Abeta40 or Abeta42 levels in DS. This lack of correlation between neopterin and Abeta levels suggests that the higher neopterin concentrations in DS group reflect inflammatory cell activation rather than AD neuropathology.
Mehta
Pankaj D
PD
Department of Immunology, Institute For Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA. pdmehta@worldnet.att.net
Patrick
Bruce A
BA
Dalton
Arthur J
AJ
Patel
Bindu
B
Mehta
Sangita P
SP
Pirttila
Tuula
T
Coyle
Patricia K
PK
D000328:Adult; D000367:Age Factors; D000544:Alzheimer Disease / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000097:blood; D001057:Apolipoproteins E / Q000235:genetics; D016022:Case-Control Studies; D004314:Down Syndrome / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000378:metabolism; D019798:Neopterin / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood
D016229:Amyloid beta-Peptides; D001057:Apolipoproteins E; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42); D019798:Neopterin