The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.
Manallack
David T
DT
Victorian College of Pharmacy, Monash University (Parkville Campus), 381 Royal Parade, Parkville Victoria, 3052, Australia. david.manallack@vcp.monash.edu.au
Hughes
Richard A
RA
Thompson
Philip E
PE
D000818:Animals; D001665:Binding Sites; D018360:Crystallography, X-Ray; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D010726:Phosphodiesterase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D021281:Quantitative Structure-Activity Relationship; D014970:Xanthines / Q000737:chemistry
D010726:Phosphodiesterase Inhibitors; D014970:Xanthines; D000242:Cyclic AMP; D006152:Cyclic GMP