Aberrant expression of tumor suppressor genes and their association with chimeric oncogenes in pediatric acute lymphoblastic leukemia.
Aberrant expression of tumor suppressor genes WT 1, RB 1, p53, homozygous deletion of p16 gene and their relationship with expression of oncogenes BCR-ABL, TEL-AML 1, MLL-AF 4, E2A-PBX 1, SIL-TAL 1 were determined in bone marrow samples of children with de novo B-lineage (n=170) and T-lineage (n=25) acute lymphoblastic leukemia (ALL). In contrast to expression of chimeric oncogenes alterations in p16, WT 1, RB 1 and p53 expression were T/B-lineage-unrestricted. Significant association between expression of MLL-AF 4 and WT 1, E2A-PBX 1 and p53; SIL-TAL 1 and homozygous deletion of p16 has been demonstrated.
Kustanovich
Anatoly M
AM
Laboratory of Molecular Biology, Belarussian Research Center for Pediatric Oncology and Hematology, P.O. Lesnoye, Minsk 223040, Belarus. akustanovich@tut.by
Savitskaja
Tatjana V
TV
Bydanov
Oleg I
OI
Belevtsev
Michael V
MV
Potapnev
Michael P
MP
D000293:Adolescent; D045744:Cell Line, Tumor; D002648:Child; D002675:Child, Preschool; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics; D005260:Female; D017353:Gene Deletion; D015972:Gene Expression Regulation, Neoplastic; D016161:Genes, Retinoblastoma / Q000235:genetics; D016147:Genes, Tumor Suppressor; D016162:Genes, Wilms Tumor; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D007223:Infant; D008297:Male; D009857:Oncogenes / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000235:genetics*; D011379:Prognosis
D019941:Cyclin-Dependent Kinase Inhibitor p16