[Comparative investigation of structural and gene somatic mutations in workers of nuclear chemical plants. I. A study of stable and unstable chromosome aberrations].
A study of frequency of unstable chromosome aberrations in 50 workers of nuclear chemical plants in remote period after beginning or finishing professional contact with ionizing radiation was carried out. 14 persons from this cohort were mainly whole-body exposed to external gamma-rays and 36 were exposed to combined external and internal radiation from incorporated Pu nuclides. In results of this irradiating practically every subject had a chronical radiation sickness. In the 1-st group the frequency of unstable aberrations varied from 0.2 to 3.6 per 100 cells and exceeded reliably control level in 5 persons. In the 2-nd group the frequency of unstable aberrations varied from 0 to 11.6 per 100 cells and exceeded reliably control level in 20 examined workers. The FISH study of frequency of stable aberrations was performed in 13 subjects who were exposed to combined external and internal radiation. Total frequency of complete and incomplete translocations varied from 0.6 to 18.5 aberrations per genome per 100 cells and reliable exceeded control level in 9 subjects. Non-random participation in exchange rearrangements (translocations) was revealed for used set of chromosomes (2, 3 and 8).
Sevan'kaev
A V
AV
Shkavrova
T G
TG
Potetnia
O I
OI
Mikhaĭlova
G F
GF
Tsepenko
V V
VV
Golub
E V
EV
Khvostunov
I K
IK
Saenko
A S
AS
Gasteva
G N
GN
Nugis
V Iu
VIu
Molokanov
A A
AA
D000328:Adult; D000368:Aged; D043171:Chromosomal Instability; D002869:Chromosome Aberrations; D002889:Chromosomes, Human, Pair 2 / Q000528:radiation effects; D002893:Chromosomes, Human, Pair 3 / Q000528:radiation effects; D002898:Chromosomes, Human, Pair 8 / Q000528:radiation effects; D015331:Cohort Studies; D003627:Data Interpretation, Statistical; D005260:Female; D005500:Follow-Up Studies; D005720:Gamma Rays; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009784:Occupational Diseases / Q000235:genetics*; D016273:Occupational Exposure; D011005:Plutonium / Q000009:adverse effects*; D011210:Power Plants; D011832:Radiation Injuries / Q000209:etiology* / Q000235:genetics*; D013997:Time Factors; D014178:Translocation, Genetic
D011005:Plutonium