SCHIP: statistics for chromosome interphase positioning based on interchange data.
The position of chromosomes in the interphase nucleus is believed to be associated with a number of biological processes. Here, we present a web-based application that helps analyze the relative position of chromosomes during interphase in human cells, based on observed radiogenic chromosome aberrations. The inputs of the program are a table of yields of pairwise chromosome interchanges and a proposed chromosome geometric cluster. Each can either be uploaded or selected from provided datasets. The main outputs are P-values for the proposed chromosome clusters. SCHIP is designed to be used by a number of scientific communities interested in nuclear architecture, including cancer and cell biologists, radiation biologists and mathematical/computational biologists.
Vives
Sergi
S
Departmento de Estadistica, Universidad de Barcelona Barcelona 08028, Spain.
Loucas
Bradford
B
Vazquez
Mariel
M
Brenner
David J
DJ
Sachs
Rainer K
RK
Hlatky
Lynn
L
Cornforth
Michael
M
Arsuaga
Javier
J
D002869:Chromosome Aberrations / Q000528:radiation effects*; D002874:Chromosome Mapping / Q000379:methods*; D003627:Data Interpretation, Statistical; D007399:Interphase / Q000235:genetics* / Q000528:radiation effects; D008957:Models, Genetic; D015233:Models, Statistical; D012854:Sister Chromatid Exchange / Q000235:genetics* / Q000528:radiation effects; D012984:Software; D014584:User-Computer Interface