Retinoic acid isomers protect hippocampal neurons from amyloid-beta induced neurodegeneration.
Attenuating amyloid-beta mediated neurodegeneration is of major therapeutic consideration in the potential treatment of Alzheimer disease. Previously, we found that a high dietary consumption of retinoic acid was associated with a reduced incidence of Alzheimer disease. Therefore, in this study, we investigated whether amyloid-beta mediated cell death in primary hippocampal neurons could be prevented by retinoic acid isomers. Our results suggest that retinoic acid isomers, including all-trans retinoic acid, 9-cis retinoic acid, and 13-cis retinoic acid, may play an important role in protecting neurons from amyloid-beta -induced cell death. Retinoic acid may therefore afford a novel therapeutic mechanism for the treatment and prevention of Alzheimer disease.
Sahin
M
M
Akdeniz University, Faculty of Medicine, Department of Biochemistry and Department of Medical Biology and Genetics, Antalya- Turkey.
Karauzum
S B
SB
Perry
G
G
Smith
M A
MA
Aliciguzel
Y
Y
D000077556:Alitretinoin; D016229:Amyloid beta-Peptides / Q000633:toxicity*; D000818:Animals; D000831:Animals, Newborn; D002452:Cell Count; D016923:Cell Death / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006624:Hippocampus / Q000166:cytology*; D015474:Isotretinoin / Q000494:pharmacology; D009410:Nerve Degeneration / Q000139:chemically induced / Q000473:pathology*; D009474:Neurons / Q000187:drug effects*; D010446:Peptide Fragments / Q000633:toxicity*; D020033:Protein Isoforms / Q000494:pharmacology*; D051381:Rats; D014212:Tretinoin / Q000494:pharmacology*
D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; D020033:Protein Isoforms; C074636:amyloid beta-protein (25-35); D000077556:Alitretinoin; D014212:Tretinoin; D015474:Isotretinoin