Occasional transsynaptic viral labeling in the central nervous system from the polycystic ovary induced by estradiol valerate.
Increased density of catecholaminergic nerves in the human polycystic ovary has been observed. The aim of the present study was to investigate the distribution of transsynaptically virus-labeled neurons in the central nervous system from the rat polycystic ovary to see whether is it different or not from that of cycling control rats. To induce a polycystic ovary, a single injection of estradiol valerate was given to adult female rats and 30 days later a neurotropic virus was injected into the right ovary. Rats were sacrificed 72 or 96 hours after viral infection. Weight of the ovaries of the estradiol valerate-treated rats was significantly lower compared to controls, and the histology of the ovaries of the treated rats displayed severely atretic large antral follicles. There was almost no viral labeling in the central nervous system from the ovaries showing precystic morphology, in spite of the fact that such altered organs are rich in nerve fibres. It is assumed that presently unidentified factors in the precystic ovary, presumably related to the link between the immune and the nervous system, might be involved in the infectivity of the virus, and thus be responsible for the lack of viral labeling from such an ovary.
Gerendai
Ida
I
Neuroendocrine Research Laboratory, Hungarian Academy of Sciences and Semmelweis University, Department of Human Morphology and Developmental Biology, H-1094 Budapest, Hungary. gerendai@ana2.sote.hu
Wiesel
Ory
O
Tóth
Ida E
IE
Boldogköi
Zsolt
Z
Hornyák
Akos
A
Halász
Béla
B
D000818:Animals; D001921:Brain / Q000821:virology*; D004958:Estradiol / Q000031:analogs & derivatives; D005260:Female; D011558:Herpesvirus 1, Suid / Q000302:isolation & purification*; D007150:Immunohistochemistry; D009474:Neurons / Q000821:virology; D009929:Organ Size; D010053:Ovary / Q000473:pathology; D011085:Polycystic Ovary Syndrome / Q000139:chemically induced / Q000473:pathology / Q000821:virology*; D011557:Pseudorabies / Q000503:physiopathology / Q000821:virology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000821:virology*; D013569:Synapses / Q000821:virology
D004958:Estradiol