The diagnostic utility of cardiac biomarkers in detecting myocardial infarction.
Cardiac biomarkers, eg, cardiac troponin, have become the standard test in combination with clinical and electrocardiographic findings for physicians to conduct prompt and effective triage of patients presenting with chest pain. Cardiac biomarkers are protein components of cell structures that are released into circulation when myocardial injury occurs. The purpose of this article is multifold. First, to identify specific cardiac biomarkers and review current guidelines based on study findings on the diagnostic utility of cardiac biomarkers in detecting myocardial infarction. Recent guidelines of the European Society of Cardiology, the American College of Cardiology, the American Heart Association, and the National Academy of Clinical Biochemistry were examined, as well as relevant studies relating to the development of these guidelines. Second, to analyze the clinical significance of cardiac biomarker measurements and the challenges with existing cardiac biomarker assays. Third, to discuss our findings regarding our evaluation of the analytical performance of a chemiluminescent microparticle immunoassay for the quantitative determination of cardiac troponin I in human serum and plasma on an automated immunoassay instrument system (ARCHITECT) to aid in the diagnosis of myocardial infarction.
Apple
Fred S
FS
Clinical Laboratories, Hennepin County Medical Center, 701 Park Avenue, Minneapolis, MN 55415, USA. fred.apple@co.hennepin.mn.us
Murakami
MaryAnn M
MM
D015415:Biomarkers / Q000097:blood; D002637:Chest Pain / Q000175:diagnosis* / Q000209:etiology; D004569:Electroencephalography; D006801:Humans; D007124:Immunoenzyme Techniques; D008163:Luminescent Measurements; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology; D017410:Practice Guidelines as Topic; D014218:Triage; D019210:Troponin I / Q000097:blood*
D015415:Biomarkers; D019210:Troponin I