title: Earlier onset of Alzheimer disease symptoms in latino individuals compared with anglo individuals.
abstract: BACKGROUND
  Latino individuals are the largest minority group and the fastest growing population group in the United States, yet there are few studies comparing the clinical features of Alzheimer disease (AD) in this population with those found in Anglo (white non-Latino) patients.
  
  
  OBJECTIVE
  To compare the age at AD symptom onset in Latino and Anglo individuals.
  
  
  METHODS
  Cross-sectional assessment using standardized methods to collect and compare age at AD symptom onset, demographic variables, and medical variables.
  
  
  METHODS
  Five National Institute on Aging-sponsored Alzheimer's Disease Centers with experience evaluating Spanish-speaking individuals.
  
  
  METHODS
  We evaluated 119 Latino and 55 Anglo patients who had a diagnosis of AD.
  
  
  METHODS
  Age at symptom onset.
  
  
  RESULTS
  After adjusting for center, sex, and years of education, Latino patients had a mean age at symptom onset 6.8 years earlier (95% confidence interval, 3.5-10.3 years earlier) than Anglo patients.
  
  
  CONCLUSIONS
  An earlier age at symptom onset suggests that US mainland Latino individuals may experience an increased burden of AD compared with Anglo individuals. The basis for the younger age at symptom onset remains obscure.
authors.affiliation: Department of Neurology, Alzheimer's Disease Center, University of Pennsylvania, Philadelphia 19104, USA. clarkc@mail.med.upenn.edu
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Clark
authors.forename: Charles
authors.initials: C
authors.lastname: DeCarli
authors.forename: Dan
authors.initials: D
authors.lastname: Mungas
authors.forename: Helena I
authors.initials: HI
authors.lastname: Chui
authors.forename: Roger
authors.initials: R
authors.lastname: Higdon
authors.forename: Jessica
authors.initials: J
authors.lastname: Nuñez
authors.forename: Henrique
authors.initials: H
authors.lastname: Fernandez
authors.forename: Mirna
authors.initials: M
authors.lastname: Negrón
authors.forename: Jennifer
authors.initials: J
authors.lastname: Manly
authors.forename: Steven
authors.initials: S
authors.lastname: Ferris
authors.forename: Angelica
authors.initials: A
authors.lastname: Perez
authors.forename: Migdalia
authors.initials: M
authors.lastname: Torres
authors.forename: Douglas
authors.initials: D
authors.lastname: Ewbank
authors.forename: Guila
authors.initials: G
authors.lastname: Glosser
authors.forename: Gerald
authors.initials: G
authors.lastname: van Belle
mesh_terms: D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000208:ethnology*; D016022:Case-Control Studies; D017281:Cost of Illness; D003430:Cross-Sectional Studies; D004522:Educational Status; D005260:Female; D015577:Geriatric Assessment; D006630:Hispanic or Latino / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D044465:White People / Q000706:statistics & numerical data*