Cre-ating somatic cell genetic mosaics in the mouse.
Generation of somatic mosaics in which mutant cell clones are uniquely and completely labeled has yielded considerable insight into many biological processes in Drosophila. In this issue of Cell, describe a novel method called MADM that allows the generation of such mosaics in mice.
Anthony
Todd E
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Heintz
Nathaniel
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D000818:Animals; D019070:Cell Lineage / Q000235:genetics; D004330:Drosophila / Q000235:genetics; D005819:Genetic Markers; D005821:Genetic Techniques; D049452:Green Fluorescent Proteins / Q000235:genetics; D019426:Integrases / Q000235:genetics*; D008164:Luminescent Proteins / Q000235:genetics; D051379:Mice; D008938:Mitosis / Q000235:genetics; D009030:Mosaicism; D016254:Mutagenesis, Insertional / Q000235:genetics / Q000379:methods; D009154:Mutation / Q000235:genetics; D011995:Recombination, Genetic / Q000235:genetics*; D000097573:Red Fluorescent Protein
D005819:Genetic Markers; D049452:Green Fluorescent Proteins; D019426:Integrases; D008164:Luminescent Proteins; D000097573:Red Fluorescent Protein; C045073:Cre recombinase