title: The roles of vitamin C in Helicobacter pylori associated gastric carcinogenesis.
abstract: Ascorbic acid, as one of the important water-soluble vitamins, is essential for a range of physiological functions, including the syntheses of collagen, carnitine and neurotransmitters. It is also an important dietary antioxidant against oxidative stress. Current information suggests that vitamin C might be protective against the development of gastric cancer. Chronic infection with Helicobacter pylori is recognized to be a significant cause of gastric adenocarcinoma. Inflammation induced by H. pylori infection in the stomach not only causes significantly enhanced consumption of vitamin C, but also reduces secretion of the vitamin into the gastric lumen. Most of the evidence relating to vitamin C and H. pylori infection derives from clinical studies and experiments directly examining the effect of vitamin C on H. pylori-associated gastric carcinogenesis and remains limited. Furthermore, results from recent studies suggest that vitamin C might also increase the risk of cancer through its pro-oxidant activity and protect against oxidative stress in cancer cells through its antioxidant action. In this article we review recent publications on vitamin C research and assess the potential roles of vitamin C in H. pylori associated gastric carcinogenesis. The possible adverse effects of the vitamin C are also discussed.
authors.affiliation: St George's Hospital Medical School, London, UK.
authors.forename: Zun Wu
authors.initials: ZW
authors.lastname: Zhang
authors.forename: Michael J G
authors.initials: MJ
authors.lastname: Farthing
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000382:microbiology* / Q000503:physiopathology*; D000818:Animals; D000975:Antioxidants / Q000009:adverse effects / Q000502:physiology; D001205:Ascorbic Acid / Q000009:adverse effects / Q000276:immunology / Q000502:physiology*; D005753:Gastric Mucosa / Q000502:physiology; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000382:microbiology* / Q000503:physiopathology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000975:Antioxidants; D001205:Ascorbic Acid