title: Bupropion SR vs placebo for smoking cessation in health care professionals.
abstract: OBJECTIVE
  To evaluate bupropion SR for smoking cessation in physicians and nurses.
  
  
  METHODS
  This double-blind prospective 26-center, 12-country trial randomized 687 subjects to smoking cessation counselling with bupropion SR or placebo for 7 weeks. The participants were followed for 52 weeks.
  
  
  RESULTS
  Bupropion SR was superior to placebo (50% vs 40%, P=0.013) on the 4-week primary outcome variable. Due to a high placebo response in this health care population, statistical differences were not maintained after treatment was discontinued.
  
  
  CONCLUSIONS
  Bupropion SR is effective and well tolerated in health care professionals. Relapse prevention measures are needed to attain long-term abstinence.
authors.affiliation: University Medical Policlinic, 10011 Lausanne, Switzerland. zellwegerjp@swissonline.ch
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Zellweger
authors.forename: Pal Laszio
authors.initials: PL
authors.lastname: Boelcskei
authors.forename: Laura
authors.initials: L
authors.lastname: Carrozzi
authors.forename: Ruth
authors.initials: R
authors.lastname: Sepper
authors.forename: Ruth
authors.initials: R
authors.lastname: Sweet
authors.forename: Amy Z
authors.initials: AZ
authors.lastname: Hider
mesh_terms: D000328:Adult; D016642:Bupropion / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D019049:Developed Countries; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009726:Nurses; D010820:Physicians; D010919:Placebos; D011446:Prospective Studies; D012907:Smoking / Q000453:epidemiology; D016540:Smoking Cessation / Q000379:methods
chemical_list: D003692:Delayed-Action Preparations; D018765:Dopamine Uptake Inhibitors; D010919:Placebos; D016642:Bupropion