title: [Excretion of beta-elemene from rat respiratory tracts].
abstract: OBJECTIVE
  To investigate the excretion of beta-elemene from the respiratory tracts in male Spraque-Dawley rats.
  
  
  METHODS
  After a single administration of beta-elemene to rats at the dosage of 75 mg x kg(-1) (i.v. or i.p.), the exhaled gases were collected and concentrated at various time points. The residues were analyzed by gas chromatography.
  
  
  RESULTS
  A minor amount of unchanged beta-elemene was excreted via rat respiratory tracts after iv and ip administration of a single dose. The cumulative excretion were 1.41% and 0.51% respectively.
  
  
  CONCLUSIONS
  The results demonstrated that unchanged beta-elemene excretes from rat respiratory tracts, but may not be the main elimination pathway in rats.
authors.affiliation: Department of Pharmacology, Dalian Medical University, Dalian 116027, China. liaoningdmu@yahoo.com.cn
authors.forename: Kun
authors.initials: K
authors.lastname: Wang
authors.forename: Zhi
authors.initials: Z
authors.lastname: Li
authors.forename: Yu-ren
authors.initials: YR
authors.lastname: Chen
authors.forename: Xiu-ying
authors.initials: XY
authors.lastname: Wu
authors.forename: Shu-yuan
authors.initials: SY
authors.lastname: Li
authors.forename: Cheng-ye
authors.initials: CY
authors.lastname: Su
mesh_terms: D000818:Animals; D002849:Chromatography, Gas; D030024:Curcuma / Q000737:chemistry; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012137:Respiratory System / Q000378:metabolism*; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*
chemical_list: D012717:Sesquiterpenes; C445979:beta-elemene