New cyclomaltoheptaose (beta-cyclodextrin) derivative 2-O-(2-hydroxybutyl)cyclomaltoheptaose: preparation and its application for the separation of enantiomers of drugs by capillary electrophoresis.
A new soluble cyclomaltoheptaose (cyclodextrin) derivative, 2-O-(2-hydroxybutyl)cyclomaltoheptaose [2-O-(2-hydroxybutyl)-beta-cyclodextrin, 2-HB-beta-CD], was prepared and studied as an efficient chiral selector in the separation of racemic mixtures of drugs by capillary electrophoresis (CE). Results showed that 2-HB-beta-CD could provide higher separating capability than that of beta-CD and the similarly substituted 2-HP-beta-CD.
Zhao
Ming-gang
MG
School of Chemistry and Chemical Engineering, Shandong University, Jinan, PR China.
Hao
Ai-you
AY
Li
Jian
J
Wei
Yun-he
YH
Guo
Peng
P
D019075:Electrophoresis, Capillary; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000302:isolation & purification*; D013237:Stereoisomerism; D047392:beta-Cyclodextrins / Q000138:chemical synthesis* / Q000737:chemistry*
C504609:2-O-(2-hydroxybutyl)cyclomaltoheptaose; D004364:Pharmaceutical Preparations; D047392:beta-Cyclodextrins