title: Notch: control of lymphocyte differentiation in the periphery.
abstract: The complexity of the Notch signalling pathway has impeded progress in understanding its precise role in differentiation processes of the mature peripheral immune system. Nevertheless, both B and T lymphocyte responses are undoubtedly influenced by Notch ligation, and defining the mechanisms by which this is achieved remains a challenge. How the innate-adaptive interface and interactions between lymphocytes can be affected, together with the potential of this pathway for therapeutic intervention remain important and stimulating issues.
authors.affiliation: Section of Immunology and Infection, Department of Biological Sciences, Imperial College, London, UK. m.dallman@imperial.ac.uk
authors.forename: Margaret J
authors.initials: MJ
authors.lastname: Dallman
authors.forename: Emma
authors.initials: E
authors.lastname: Smith
authors.forename: Robert A
authors.initials: RA
authors.lastname: Benson
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Lamb
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002454:Cell Differentiation; D005786:Gene Expression Regulation; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D051880:Receptors, Notch; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*
chemical_list: D008565:Membrane Proteins; D051880:Receptors, Notch