title: Fecal Adnab-9 binding as a risk marker for colorectal neoplasia.
abstract: Adnab-9 binding in colonic tissue and effluent has been associated with an increased risk for colorectal neoplasia. We investigated if fecal binding by Adnab-9 may be used as a marker for colorectal neoplasia. A fecal-Adnab-9 ELISA was performed on samples of 249 patients and colonoscopic pathology results correlated. Fecal Adnab-9 binding was seen in 63% of patients with colorectal neoplasia (59% with colorectal cancer and 83% with adenoma), 33% with inflammatory bowel disease, 0% with hyperplastic polyps and 10% of controls. We conclude that fecal Adnab-9 binding is a promising risk marker for colorectal neoplasia.
authors.affiliation: Institute of Basic Medical Science, General Hospital of PLA, Beijing, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Yuan
authors.forename: XiaoPing
authors.initials: X
authors.lastname: Xhang
authors.forename: YiaLi
authors.initials: Y
authors.lastname: Leu
authors.forename: Yi
authors.initials: Y
authors.lastname: Xu
authors.forename: Nadeem
authors.initials: N
authors.lastname: Ullah
authors.forename: Michael
authors.initials: M
authors.lastname: Lawson
authors.forename: Martin
authors.initials: M
authors.lastname: Tobi
mesh_terms: D000236:Adenoma / Q000175:diagnosis*; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000276:immunology*; D014408:Biomarkers, Tumor / Q000032:analysis*; D015179:Colorectal Neoplasms / Q000175:diagnosis*; D005243:Feces / Q000737:chemistry*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; C482718:adenoma-associated antigen glycoprotein 87, human