[Topical administration of hydralazine hydrochloride on the viability of randon skin flaps in rats].
OBJECTIVE
Assess the effect of hydralazine hydrochloride, for iontophoresis, on the viability of random skin flaps in rats.


METHODS
Sixty Wistar rats was randonly destributed in 4 groups (n=15), these animals was submited as randon dorsal skin flaps as cranial base with measure 10 x 4 cm. The animals from group 1 was utilized as control, in group 2 was submitted to direct current o 4mA-20' immediately after the surgery and on the two subsequent days. In group 3 the stimulation eletric simulation with hydralazine hydrochloride. In group 4 iontophorese with hydralazine hydrochloride 4mA-20'. The analysis of the results was made on the seventh day post operative and interpreted with test non parametric of Kruskal-Wallis.


RESULTS
and the necrotic area stayed fixed in: group 1=45%; group 2=39%; group 3=46% and group 4=41%, being the statistical analysis did not evidenced any significant.


CONCLUSIONS
The hydralazine hydrochloride when taken for iontophorese was not efficacious in reduce the necrotic area.
Junior
Ivaldo Esteves
IE
Curso de Fisioterapia da Universidade Paulista. ivaldofisio@ig.com.br
Masson
Igor Bordello
IB
Ferreira
Lydia Masako
LM
Liebano
Richard Eloin
RE
Baldan
Cristiano
C
Gomes
Alexandre Cavallieri
AC
D000287:Administration, Topical; D000818:Animals; D006830:Hydralazine / Q000008:administration & dosage*; D007478:Iontophoresis; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013524:Surgical Flaps
D006830:Hydralazine