[Role of chronic prostatic infiltrate from specimens of prostate biopsy in total and free PSA determination].
OBJECTIVE
To analyze the influence in total serum PSA (PSA(t)) and free PSA (PSA(1)) of chronic inflammatory patterns from prostate biopsy specimens of non-symptomatic patients.


METHODS
518 non-symptomatic patients underwent ultrasonography and prostatic biopsy for PSA(t) > 4 ng/mL and/or DRE suspicious of malignancy. Those with a negative biopsy were divided into two subgroups: patients with benign prostatic lesions (LBP) and patients with chronic inflammatory signs (SIC).


RESULTS
456 patients (88.03%) were biopsied for elevated PSA(t) or/and DRE suspicious of malignancy in 62 patients (11.97%). Mean volume in patients with LBP was 54cc, while 51cc was the mean volume in patients with histological pattern of chronic inflammatory infiltrate. Mean PSA(t) in patients with LBP was 9.43 (IC 95% +/- 7.8) and 8.8 (IC 95% +/- 5.73) in SIC's group patients.


CONCLUSIONS
The presence of SIC has no significant influence in the eventual value of PSA(1) y PSA(t) in a selected population. As a result of that finding data from serum PSA can be reliably evaluated even in the presence of SIC in biopsy specimens.
Gómez Pérez
L
L
Servicio de Urología, Hospital Universitario La Fe, Valencia.
Budía Alba
A
A
Benedicto Redón
A
A
Delgado Oliva
F J
FJ
Palmero Martí
J L
JL
Jiménez Cruz
J F
JF
D000368:Aged; D001707:Biopsy, Needle; D002908:Chronic Disease; D006801:Humans; D008297:Male; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood*; D011472:Prostatitis / Q000097:blood / Q000473:pathology*; D012189:Retrospective Studies
D017430:Prostate-Specific Antigen