Serum copper, ceruloplasmin and thiobarbituric acid reactive substance status in patients with ovarian cancer.
Serum copper, ceruloplasmin and thiobarbituric acid reactive substances (TBARS) were estimated in 30 patients of ovarian cancer. The copper to ceruloplasmin ratio was moderately increased (P<0.05) but the copper (P<0.01( and ceruloplasmin (P<0.001) levels were significantly increased in ovarian cancer patients as compared to controls. TBARS levels were also found to be highly significant (P<0.001). Trace elements and free radicals have been implicated in the etiology of cancer. Hence the estimation of antioxidants like ceruloplasmin and TBARS along with the trace element like copper may be of value in the early diagnosis of cancer.
Nayak
Shivananda B
SB
Departments of Biochemistry and Medical Education, Kasturba Medical College, Manipal - 576 104.
Bhat
Vinutha R
VR
Mayya
Srimathi S
SS
D000328:Adult; D000368:Aged; D018394:CA-125 Antigen / Q000097:blood; D002570:Ceruloplasmin / Q000032:analysis*; D003300:Copper / Q000097:blood*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood*; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis*
D018394:CA-125 Antigen; D017392:Thiobarbituric Acid Reactive Substances; D003300:Copper; D002570:Ceruloplasmin