title: Association of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) genotype with depression in elderly persons after hip fracture.
abstract: OBJECTIVE
  The authors examined the serotonin transporter gene-linked polymorphic region (5-HTTLPR) as a predictor of major depressive disorder and depressive symptoms after hip fracture, a common stressful medical event.
  
  
  METHODS
  This was a prospective, observational study of 23 elderly rehabilitation-hospital patients during their inpatient stay. Depressive symptoms were assessed by Hamilton Rating Scale for Depression (Ham-D) and PRIME-MD. Subjects were also genotyped for 5-HTTLPR.
  
  
  RESULTS
  Survival analysis showed that genotype significantly predicted time-to-major depressive episode. Subjects with an s allele (genotype s/l or s/s) had significantly higher Ham-D scores over 14 weeks of follow-up than those with the l/l genotype.
  
  
  CONCLUSIONS
  Depressive symptoms and major depressive disorder in elderly persons after a stressful medical event may be associated with 5-HTTLPR genotype. This finding requires confirmation in a larger sample.
authors.affiliation: Intervention Research Center for the Study of Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburg School of Medicine, Pittsburgh, PA, USA. lenzeej@upmc.edu
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Lenze
authors.forename: Michael C
authors.initials: MC
authors.lastname: Munin
authors.forename: Robert E
authors.initials: RE
authors.lastname: Ferrell
authors.forename: Bruce G
authors.initials: BG
authors.lastname: Pollock
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Skidmore
authors.forename: Francis
authors.initials: F
authors.lastname: Lotrich
authors.forename: Joan C
authors.initials: JC
authors.lastname: Rogers
authors.forename: Tanya
authors.initials: T
authors.lastname: Quear
authors.forename: Patricia
authors.initials: P
authors.lastname: Houck
authors.forename: Charles F
authors.initials: CF
authors.lastname: Reynolds
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics*; D005838:Genotype; D006620:Hip Fractures / Q000523:psychology*; D006720:Homozygote; D006801:Humans; D008016:Life Change Events; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins