An adult case of acute lymphoblastic leukaemia presenting as hepatic dysfunction.
Acute hepatic dysfunction is a rare and often fatal presentation of haematological malignancies. We describe an adult case of acute lymphoblastic leukaemia presenting as an acute hepatitis. Due to the elevation in the patient's transaminases and bilirubin, standard acute lymphoblastic leukaemia induction therapy could not be used. Instead the combination of prednisone and asaparaginase were used to successfully induce remission.
Aoki
C A
CA
Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of California Davis Medical Centre, 4150 V Street, Suite 3500, Sacramento, CA 95817, USA.
Bowlus
C L
CL
Rossaro
L
L
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001215:Asparaginase / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008107:Liver Diseases / Q000209:etiology*; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use
D000970:Antineoplastic Agents; D005938:Glucocorticoids; D001215:Asparaginase; D011241:Prednisone