Cholesteryl ester transfer protein (CETP) I405V polymorphism and longevity in Italian centenarians.
A common polymorphism (I405V) in exon 14 of the cholesteryl ester transfer protein (CETP) gene has been recently associated to healthy aging in Ashkenazi Jewish. In order to study this genetic effect in long-lived individuals with a different ethnicity, we analyzed the allele and genotype distributions of the CETP polymorphism a sample of Italian centenarians. Our result does not confirm the association between the I405V CETP variation and the healthy aging phenotype described in the Ashkenazi Jewish population and suggests that other gene environment interactions contribute to longevity.
Cellini
Elena
E
Department of Neurological and Psychiatric Sciences, University of Florence, Italy.
Nacmias
Benedetta
B
Olivieri
Fabiola
F
Ortenzi
Luigi
L
Tedde
Andrea
A
Bagnoli
Silvia
S
Petruzzi
Concetta
C
Franceschi
Claudio
C
Sorbi
Sandro
S
D000368:Aged; D000369:Aged, 80 and over; D002352:Carrier Proteins / Q000235:genetics*; D053480:Cholesterol Ester Transfer Proteins; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D007438:Introns / Q000235:genetics*; D007558:Italy; D007585:Jews; D008136:Longevity / Q000235:genetics*; D011110:Polymorphism, Genetic
C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D006023:Glycoproteins