title: Image metrics for predicting subjective image quality.
abstract: OBJECTIVE
  Despite the proliferation of wavefront sensors to characterize the optical quality of individual eyes, there is not yet an accurate way to determine from a wave aberration how severely it will impact the patient's vision. Some of the most commonly used metrics, such as RMS wavefront error and the Strehl ratio, predict subjective image quality poorly. Our goal is to establish a better metric to predict subjective image quality from the wave aberration.
  
  
  METHODS
  We describe three kinds of experiments designed to compare the effectiveness of different metrics in determining the subjective impact of the wave aberration. Subjects viewed a visual stimulus through a deformable mirror in an adaptive optics system that compensated for the subject's wave aberration. In the first experiment, we show that some Zernike modes such as spherical aberration and defocus interact strongly in determining subjective image quality. In the second experiment, the subject's wave aberration was replaced by the wave aberration corresponding to an individual Zernike mode. The subject then adjusted the coefficient of the Zernike mode to match the blur of a standard stimulus. In the third experiment, the subject viewed the same stimulus through the wave aberration of one of 59 different postoperative patients who had undergone LASIK and matched the blur by adjusting defocus. We then determined which among many image quality metrics best predicted these matching data.
  
  
  RESULTS
  RMS wavefront error was a poor predictor of the data, as was the Strehl ratio.
  
  
  CONCLUSIONS
  The neural sharpness metric best described the subjective sharpness of images viewed through the wave aberrations of real eyes. This metric can provide a single number that describes the subjective impact of each patient's wave aberration and will also increase the accuracy of refraction estimates from wavefront-based autorefractors and phoropters.
authors.affiliation: Center for Visual Science, University of Rochester, Rochester, New York (LC, BS, JP, DRW) and Departamento de Física, Universidad de Murcia, Murcia, Spain (AG).
authors.forename: L I
authors.initials: LI
authors.lastname: Chen
authors.forename: Ben
authors.initials: B
authors.lastname: Singer
authors.forename: Antonio
authors.initials: A
authors.lastname: Guirao
authors.forename: Jason
authors.initials: J
authors.lastname: Porter
authors.forename: David R
authors.initials: DR
authors.lastname: Williams
mesh_terms: D006801:Humans; D009799:Ocular Physiological Phenomena; D009907:Optometry / Q000379:methods; D012029:Refraction, Ocular / Q000502:physiology*; D014787:Vision Tests; D014792:Visual Acuity / Q000502:physiology*