Catalytic enantioselective thioester aldol reactions that are compatible with protic functional groups.
This communication reports highly enantioselective and diastereoselective methyl malonic acid half thioester (MeMAHT) aldol reactions that are compatible with protic functional groups and enolizable aldehydes, affording syn S-phenyl thiopropionates.
Magdziak
Derek
D
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
Lalic
Gojko
G
Lee
Hong Myung
HM
Fortner
Kevin C
KC
Aloise
Allen D
AD
Shair
Matthew D
MD