title: The synthesis of water soluble decalin-based thiols and S-nitrosothiols--model systems for studying the reactions of nitric oxide with protein thiols.
abstract: The syntheses of three decalin-based tert-thiols displaying varying degrees of solubility in aqueous milieu are described. The S-nitroso derivatives of these compounds have also been prepared and the structures of two of these determined by single crystal X-ray diffraction. These compounds have been designed for studying the interaction of nitric oxide (NO) with thiols under physiological conditions.
authors.affiliation: Department of Chemistry, Imperial College, South Kensington campus, London, UK SW7 2AZ.
authors.forename: Alan C
authors.initials: AC
authors.lastname: Spivey
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Colley
authors.forename: Lindsey
authors.initials: L
authors.lastname: Sprigens
authors.forename: Susan M
authors.initials: SM
authors.lastname: Hancock
authors.forename: D Stuart
authors.initials: DS
authors.lastname: Cameron
authors.forename: Kordi I
authors.initials: KI
authors.lastname: Chigboh
authors.forename: Gemma
authors.initials: G
authors.lastname: Veitch
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Frampton
authors.forename: Harry
authors.initials: H
authors.lastname: Adams
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009281:Naphthalenes / Q000737:chemistry*; D009569:Nitric Oxide / Q000737:chemistry*; D012995:Solubility; D021241:Spectrometry, Mass, Electrospray Ionization; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D009281:Naphthalenes; D013438:Sulfhydryl Compounds; D014867:Water; D009569:Nitric Oxide; C007229:decalin