No association between the ionotropic glutamate receptor kainate 3 gene ser310ala polymorphism and schizophrenia.
The etiology of schizophrenia has been suggested to be associated with the dysfunction of the glutamatergic system. A positive association between the ionotropic glutamate receptor kainate 3 gene (GRIK3) T928G polymorphism and schizophrenia has been reported, which suggests that people bearing G allele are at a higher risk for schizophrenia. Therefore, we attempted to replicate this study in Chinese with larger sample size. One hundred and sixty schizophrenic patients and 160 healthy controls participated in the current study. Genotype and allele distributions of GRIK3 T928G polymorphism in schizophrenics were similar to those of controls (p = 0.74 and p = 0.59, respectively). Our study indicated that there was no association between this polymorphism and schizophrenia, at least in Chinese.
Lai
I-Ching
IC
Department of Psychiatry, Yuli Veterans Hospital, 91 Shin-Shin Street, Yuli, Hualien 981, Taiwan.
Liou
Ying-Jay
YJ
Chen
Jen-Yeu
JY
Wang
Ying-Chieh
YC
D000328:Adult; D000409:Alanine / Q000235:genetics; D004252:DNA Mutational Analysis / Q000379:methods; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D018091:Receptors, AMPA; D017470:Receptors, Glutamate / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D012694:Serine / Q000235:genetics
D018091:Receptors, AMPA; D017470:Receptors, Glutamate; C104723:glutamate receptor ionotropic, AMPA 3; D012694:Serine; D000409:Alanine