Hypocretins: waking, arousal, or action?
The role of hypocretin (orexin) neurotransmission in waking and arousal, though of intense interest, is poorly understood. In this issue of Neuron, demonstrate that, in general, hypocretin neurons are minimally active during both sleep and quiet waking. In contrast, these neurons display robust activity during periods of alert and/or active waking.
Berridge
Craig W
CW
Psychology Department, University of Wisconsin, Madison, Wisconsin 53706, USA.
España
Rodrigo A
RA
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001143:Arousal / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D064446:Orexin Receptors; D043562:Receptors, G-Protein-Coupled; D018013:Receptors, Neuropeptide / Q000378:metabolism / Q000502:physiology*
D064446:Orexin Receptors; D043562:Receptors, G-Protein-Coupled; D018013:Receptors, Neuropeptide