Metabolic adaptation at birth.
After birth, the neonate must make a transition from the assured continuous transplacental supply of glucose to a variable fat-based fuel economy. The normal infant born at term accomplishes this transition through a series of well-coordinated metabolic and hormonal adaptive changes. The patterns of adaptation in the preterm infant and the baby born after intrauterine growth restriction are, however, different to that of a full-term neonate, with the risk for former groups that there will be impaired counter-regulatory ketogenesis. There is much less precise linkage of neonatal insulin secretion to prevailing blood glucose concentrations. These patterns of metabolic adaptation are further influenced by feeding practices.
Ward Platt
Martin
M
Newcastle Neonatal Services, Royal Victoria Infirmary, Department of Child Health, Queen Victoria Road, Newcastle upon Tyne NE1 4 LP, UK. m.p.ward-platt@ncl.ac.uk
Deshpande
Sanjeev
S
D000222:Adaptation, Physiological / Q000502:physiology*; D001786:Blood Glucose / Q000032:analysis; D001903:Bottle Feeding; D001942:Breast Feeding; D005947:Glucose / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn / Q000378:metabolism*; D007234:Infant, Premature / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007657:Ketone Bodies / Q000378:metabolism
D001786:Blood Glucose; D007328:Insulin; D007657:Ketone Bodies; D005947:Glucose