title: Gene therapy of pituitary diseases.
abstract: Despite a stuttering course, gene therapy continues to provide a potential treatment avenue for many human diseases, including cancer and various inherited disorders. Gene therapy is also attractive for the treatment of local, benign disorders, such as pituitary adenomas. Advances in technology have focused on modifying existing viral vectors and developing targeted expression of therapeutic genes in an effort to achieve efficacy with minimal toxicity. Gene therapy also offers innovative strategies for treating hypopituitarism by replacing hormones such as growth hormone (GH) and vasopressin.
authors.affiliation: Endocrinology, Metabolism, and Molecular Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA.
authors.forename: Eun Jig
authors.initials: EJ
authors.lastname: Lee
authors.forename: J Larry
authors.initials: JL
authors.lastname: Jameson
mesh_terms: D000236:Adenoma / Q000628:therapy; D000818:Animals; D018390:Gene Targeting; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors / Q000008:administration & dosage; D013006:Growth Hormone / Q000235:genetics*; D020249:Hormone Replacement Therapy / Q000379:methods*; D006801:Humans; D007018:Hypopituitarism / Q000628:therapy; D023421:Models, Animal; D010900:Pituitary Diseases / Q000628:therapy*; D010911:Pituitary Neoplasms / Q000628:therapy; D014667:Vasopressins / Q000235:genetics*
chemical_list: D014667:Vasopressins; D013006:Growth Hormone