Synthesis of methyl 1-O-(4-hydroxymethamphetaminyl)-alpha-D-glucopyranouronate.
For the purpose of the direct characterization of the intact conjugated form in the urine of a methamphetamine (MA) abuser, 4-hydroxymethamphetamine (4-OHMA) glucuronate, corresponding to one of the metabolites of MA, was synthesized from the commercially available methyl 4-hydroxyphenylacetate.
Nakajima
Rika
R
School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. nakaji@sc.itc.keio.ac.jp
Ono
Machiko
M
Aiso
Sadakazu
S
Akita
Hiroyuki
H
D020719:Glucuronides / Q000138:chemical synthesis*; D008694:Methamphetamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D014574:Uronic Acids / Q000138:chemical synthesis*
D020719:Glucuronides; D014574:Uronic Acids; D008694:Methamphetamine