[Mucosal pathologic and ultrastructure changes of experimental maxillary sinusitis in rabbits].
OBJECTIVE
To investigate mucosal pathologic and ultrastructure changes relate to experimental maxillary sinusitis process in rabbits. The demarcation of acute and chronic maxillary sinusitis will be determined according to pathologic effects.


METHODS
Thirty New Zealand white rabbits have been induced sinusitis will be divided into different groups according to the time of process. The pathologic changes are observed by microscope, scanning electric microscope and transmission electric microscope.


RESULTS
Within 3 weeks to induce infection the inflammation mainly show in acute style while after 3 weeks the main manifestation are chronic changes. In epithelium layer cilia shedding increased, the number of goblet cell added, squamous epithelium metaplasia and epithelia necrosis were observed during inflammatory process. In lamina propria glands metaplasia and decreased, the fibrosis is densed.


CONCLUSIONS
The pathologic changes of maxillary mucosa are related to process. The borderline of acute and chronic experimental maxillary sinusitis is 3 weeks.
Liu
Feng
F
Department of Otolaryngology, Changhai Hospital, the Second Military Medical University, Shanghai, 200433, China. liu626feng@sohu.com
Zhou
Shuimiao
S
Zhang
Suqin
S
Xu
Yue
Y
D000818:Animals; D005260:Female; D008297:Male; D015523:Maxillary Sinusitis / Q000473:pathology*; D008853:Microscopy; D009297:Nasal Mucosa / Q000648:ultrastructure*; D011817:Rabbits