Does linezolid cause lactic acidosis by inhibiting mitochondrial protein synthesis?
Linezolid, an oxazolidinone antibiotic, inhibits bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA). We studied 3 patients who experienced lactic acidosis while receiving linezolid therapy. The toxicity may have been caused by linezolid binding to mitochondrial 16S rRNA. Genetic polymorphisms may have contributed to the toxicity in 2 patients.
Palenzuela
Lluis
L
Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA.
Hahn
Noah M
NM
Nelson
Robert P
RP
Arno
Janet N
JN
Schobert
Carol
C
Bethel
Robert
R
Ostrowski
Lisa A
LA
Sharma
Manjuli R
MR
Datta
Partha P
PP
Agrawal
Rajendra K
RK
Schwartz
Jennifer E
JE
Hirano
Michio
M
D000081:Acetamides / Q000009:adverse effects*; D000140:Acidosis, Lactic / Q000235:genetics / Q000378:metabolism*; D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D000069349:Linezolid; D008875:Middle Aged; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D023303:Oxazolidinones / Q000009:adverse effects*; D011110:Polymorphism, Genetic; D014176:Protein Biosynthesis / Q000187:drug effects*
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid