Stability of aztreonam in AZACTAM.
The influence of temperature and relative humidity on the stability of aztreonam in AZACTAM was investigated. Changes of the concentration of aztreonam were followed using the HPLC method with UV detection. The first-order rate constants of the reversible reaction of isomerization Z-aztreonam right harpoon over left harpoonE-aztreonam and the parallel reaction Z-aztreonam-->products were determined at RH=76.4% and T=313, 323, 333, 343 and 353 K, and at T=343 K and RH=50.9%, 60.5%, 66.5% and 76.4%. The thermodynamic parameters-energy, enthalpy and entropy of these reactions were calculated.
Zajac
Marianna
M
Department of Pharmaceutical Chemistry, University of Medical Sciences in Poznań, Poznań, Poland. mzajac@amp.edu.pl
Jelińska
Anna
A
Cielecka-Piontek
Judyta
J
Oszczapowicz
Irena
I
D001398:Aztreonam / Q000032:analysis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004355:Drug Stability; D006813:Humidity; D007536:Isomerism; D007700:Kinetics; D015203:Reproducibility of Results; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013696:Temperature; D013816:Thermodynamics
D001398:Aztreonam