Testis-specific histone H3 expression in somatic cells.
Histone variants functionally differentiate individual nucleosomes and, hence, act as key regulators of chromatin structure and function. Large-scale proteomic projects are now valuable sources of histone-variant discovery, showing, in particular, that somatic mammalian cells express a larger panel of histone H3 variants than previously thought, including testis-specific variants and as yet uncharacterized species. These data also suggest a tight relationship between the complexity of histone-variant expression and physiopathological states of the cells.
Govin
Jérôme
J
INSERM U309--Laboratoire de Biologie Moléculaire et Cellulaire de la Différenciation Equipe Chromatine et expression des gènes Institut Albert Bonniot Faculté de Médecine, Domaine de la Merci 38706 La Tronche Cedex, France.
Caron
Cécile
C
Rousseaux
Sophie
S
Khochbin
Saadi
S
D000595:Amino Acid Sequence; D000818:Animals; D002477:Cells / Q000737:chemistry* / Q000378:metabolism; D015870:Gene Expression; D006657:Histones / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009707:Nucleosomes / Q000378:metabolism; D009928:Organ Specificity; D013737:Testis / Q000737:chemistry* / Q000166:cytology / Q000378:metabolism
D006657:Histones; D009707:Nucleosomes