Mu opiate active substances trefentanil and naloxonazine: tritiation at high specific activity.
Methods are presented to synthesize and characterize [propyl-(3)H] trefentanil 3 and [propenyl-(3)H] naloxonazine 6.
Ahern
David G
DG
PerkinElmer Life and Analytical Sciences, Inc., 549 Albany St., Boston, MA 02118, USA.
Egan
Judith A
JA
Seguin
Richard J
RJ
Filer
Crist N
CN
D007553:Isotope Labeling / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009270:Naloxone / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry; D010880:Piperidines / Q000032:analysis / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000032:analysis / Q000138:chemical synthesis; D017450:Receptors, Opioid, mu / Q000032:analysis* / Q000737:chemistry*; D013777:Tetrazoles / Q000032:analysis / Q000737:chemistry*; D014316:Tritium / Q000032:analysis / Q000737:chemistry*
D010880:Piperidines; D019275:Radiopharmaceuticals; D017450:Receptors, Opioid, mu; D013777:Tetrazoles; D014316:Tritium; D009270:Naloxone; C080498:trefentanil; C034643:naloxonazine