Hardy-Weinberg testing of a single homozygous genotype.
No proper statistical test is available for the evaluation of deviation of a single homozygous genotype from Hardy-Weinberg equilibrium (HWE) proportion. We propose a 1-d.f. chi2-test. The power of the proposed test is favorable compared to existing HWE testing procedures. The applications of this test are discussed.
Chen
John J
JJ
Department of Preventive Medicine, State University of New York, Stony Brook, New York 11794, USA. john.chen@stonybrook.edu
Duan
Tao
T
Single
Richard
R
Mather
Kristie
K
Thomson
Glenys
G
D005787:Gene Frequency; D005828:Genetics, Population; D005838:Genotype; D008957:Models, Genetic; D013223:Statistics as Topic / Q000379:methods*