Retinal remodeling during retinal degeneration.
Retinal degenerations, regardless of the initiating event or gene defect, often result in a loss of photoreceptors. This formal deafferentation of the neural retina eliminates the intrinsic glutamatergic drive of the sensory retina and, perhaps more importantly, removes coordinated Ca++-coupled signaling to the neural retina. As in other central nervous system degenerations, deafferentation activates remodeling. Neuronal remodeling is the common fate of all photoreceptor degenerations.
Jones
Bryan W
BW
Moran Eye Center, 75 North Medical Drive, Rm 3339A, Salt Lake City, UT 84132, USA. bryan.jones@m.cc.utah.edu
Marc
Robert E
RE
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008817:Mice, Mutant Strains; D009154:Mutation; D009473:Neuronal Plasticity; D020419:Photoreceptor Cells, Vertebrate / Q000473:pathology; D051381:Rats; D011922:Rats, Mutant Strains; D012162:Retinal Degeneration / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D015398:Signal Transduction; D014795:Visual Pathways / Q000503:physiopathology