[Vitamin D and bone quality].
Active vitamin D analogs such as alfacalcidol have been shown to reduce fracture risk in clinical trials in spite of its moderate effects on bone mass. It has been reported that active vitamin D analogs may improve bone quality, by amelioration of bone microarchitecture, by specific effect on cortical bones, by acceleration of calcification, and by effect on nature of bone matrix proteins. The bone quality assessments that clarify the effect on bone mechanical properties will become important for the positioning of osteoporosis drugs.
Shiraishi
Ayako
A
Product Research Department, Chugai Pharmaceutical Co., Ltd.
Kubota
Naoki
N
Kubodera
Noboru
N
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects*; D006801:Humans; D014807:Vitamin D / Q000494:pharmacology*
D014807:Vitamin D