Evaluation of a new intraoral controlled fluoride release device.
The aim of the study was to determine the pharmacokinetics of a new hydroxyapatite-Eudragit RS100 diffusion-controlled fluoride-releasing system designed for intraoral use with a 0.15 mg F(-)/day release for a 1-month period. Matrix tablets, each containing 18 mg of sodium fluoride, were bonded to the buccal surface of the first maxillary molar teeth of 20 subjects (age 20-23 years). Morning and evening salivary and urinary samples were collected 5 days before the study and every day for the 1st week, then once a week for 1 month. Fluoride ion measurements were done using the microdiffusion method. The salivary and urinary fluoride concentrations were significantly raised during the treatment period (p < 0.05). Morning salivary fluoride levels were higher than evening salivary fluoride levels (p < 0.05) whereas evening urinary fluoride levels were higher than morning urinary fluoride levels (p < 0.05). The statistically significant increase in salivary fluoride levels indicates a caries-preventive role for this device.
Altinova
Y B
YB
Department of Pedodontics, Faculty of Dentistry, Gazi University, TR-06510 Emek, Ankara, Turkey.
Alaçam
A
A
Aydin
A
A
Sanisoglu
S Y
SY
D000328:Adult; D002327:Cariostatic Agents / Q000008:administration & dosage*; D003692:Delayed-Action Preparations / Q000008:administration & dosage; D001840:Dental Bonding; D003731:Dental Caries / Q000517:prevention & control*; D006801:Humans; D008963:Molar; D012463:Saliva / Q000737:chemistry; D012969:Sodium Fluoride / Q000008:administration & dosage* / Q000378:metabolism; D018709:Statistics, Nonparametric
D002327:Cariostatic Agents; D003692:Delayed-Action Preparations; D012969:Sodium Fluoride