Pre-transplant reduction of isohaemagglutinin titres by donor group plasma infusion does not reduce the incidence of pure red cell aplasia in major ABO-mismatched transplants.
Major ABO incompatibility in stem cell transplant recipients has been associated with pure red cell aplasia (PRCA). Reduction of incompatible isohaemagglutinin titres pre-transplant by various methods has been thought to reduce the incidence of PRCA. Our data suggest that pre-transplant reduction of incompatible isohaemagglutinin titres by donor group plasma infusion does not reduce the incidence of PRCA. We also failed to find any relationship between pre-transplant ABO isohaemagglutinin titre and the risk of developing PRCA.
Damodar
S
S
Department of Hematology, Christian Medical College, Vellore, India.
George
B
B
Mammen
J
J
Mathews
V
V
Srivastava
A
A
Chandy
M
M
D000017:ABO Blood-Group System; D000293:Adolescent; D001787:Blood Group Incompatibility; D016026:Bone Marrow Transplantation / Q000379:methods; D002648:Child; D002675:Child, Preschool; D004913:Erythrocytes, Abnormal / Q000166:cytology*; D005260:Female; D006388:Hemagglutinins / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D008297:Male; D012010:Red-Cell Aplasia, Pure / Q000517:prevention & control*; D012189:Retrospective Studies; D013234:Stem Cells / Q000166:cytology*; D013997:Time Factors; D019172:Transplantation Conditioning / Q000379:methods
D000017:ABO Blood-Group System; D006388:Hemagglutinins