Molecular biology of esophageal cancer in the genomics era.
The incidence of esophageal adenocarcinoma is rising in the United States and Western countries. Significant differences exist between esophageal adenocarcinoma and squamous cell carcinoma in the molecular mechanisms responsible for the tumorigenesis process. State-of-the-art techniques such as gene microarrays and proteomics will greatly aid in the development of new therapies targeting specific molecular pathways,ultimately leading to improved survival in patients who have esophageal cancer.
Kwong
King F
KF
Division of Thoracic Surgery, Greenebaum Cancer Center, University of Maryland School of Medicine, 22 South Greene Street, Room N4E35, Baltimore, MD 21201, USA. kkwong@smail.umaryland.edu
D000230:Adenocarcinoma / Q000235:genetics*; D017209:Apoptosis / Q000235:genetics; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D015870:Gene Expression / Q000235:genetics; D016147:Genes, Tumor Suppressor; D023281:Genomics / Q000379:methods*; D006801:Humans; D008967:Molecular Biology / Q000379:methods*; D020411:Oligonucleotide Array Sequence Analysis; D040901:Proteomics / Q000379:methods; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics
C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A