Chromosome-borne class A BOR-1 beta-Lactamase of Bordetella bronchiseptica and Bordetella parapertussis.
A narrow-spectrum clavulanic acid-inhibited class A beta-lactamase, BOR-1, was identified in a Bordetella bronchiseptica clinical isolate. It shared 45% amino acid identity with L-2 from Stenotrophomonas maltophilia. An identical beta-lactamase gene was found in B. bronchiseptica and Bordetella parapertussis reference strains that may contribute only in part to their resistance phenotype.
Lartigue
Marie-Frédérique
MF
Service de Bactériologie-Virologie, Hôpital de Bicêtre, and Faculté de Médecine Paris-Sud, Université Paris XI, 78 rue du Général Leclerc, 94275 K.-Bicêtre, France.
Poirel
Laurent
L
Fortineau
Nicolas
N
Nordmann
Patrice
P
D000328:Adult; D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016950:Bordetella bronchiseptica / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D042483:Bordetella parapertussis / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D002876:Chromosomes, Bacterial / Q000235:genetics*; D019818:Clavulanic Acid / Q000494:pharmacology; D005260:Female; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D018440:beta-Lactam Resistance; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
D000900:Anti-Bacterial Agents; D065093:beta-Lactamase Inhibitors; D019818:Clavulanic Acid; D001618:beta-Lactamases