Learning in the Place navigation task, not the New-learning task, is altered by prenatal methamphetamine exposure.
Adult rats (prenatally methamphetamine-exposed, saline-exposed and controls) were tested for learning in the Morris water maze. Rats were tested in 4 consecutive days using two different types of learning tests: "Place navigation test" (stable platform position) and "New-learning test" (platform position changed daily). Males exposed prenatally to methamphetamine were slower in the Place navigation learning test than were both the control and saline-exposed males. There were no differences in the New-learning test between groups.
Slamberová
Romana
R
Department of Normal, Pathological and Clinical Physiology, 3rd Faculty of Medicine, Charles University, Ke Karlovu 4, 120 00 Praha 2, Prague, Czech Republic. rslamber@lf3.cuni.cz
Pometlová
Marie
M
Syllabová
Lýdia
L
Mancusková
Magdaléna
M
D019969:Amphetamine-Related Disorders / Q000503:physiopathology; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000254:growth & development* / Q000503:physiopathology; D000697:Central Nervous System Stimulants / Q000009:adverse effects; D004195:Disease Models, Animal; D005260:Female; D007859:Learning Disabilities / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D008568:Memory / Q000187:drug effects / Q000502:physiology; D008569:Memory Disorders / Q000139:chemically induced* / Q000503:physiopathology; D008694:Methamphetamine / Q000009:adverse effects*; D009949:Orientation / Q000187:drug effects / Q000502:physiology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D012727:Sex Characteristics; D012737:Sex Factors
D000697:Central Nervous System Stimulants; D008694:Methamphetamine