Effect of intermittent inhaled tobramycin on sputum cytokine profiles in cystic fibrosis.
OBJECTIVE
The aim of this study was to evaluate the anti-inflammatory properties of intermittent inhaled tobramycin.


METHODS
To establish this, we initiated a prospective study to measure the concentration of the three pro-inflammatory cytokines IL-8, IL-6 and TNF-alpha in the sputum from 20 cystic fibrosis (CF) patients (15 teenagers and 5 young adults) during cycles and off cycles.


RESULTS
A significant decrease in IL-8 (P = 0.001) and a more moderate decrease in IL-6 (P = 0.046) and TNF-alpha (P = 0.052) levels were observed during cycles, even if no significant decrease in the number of leucocytes was observed.


CONCLUSIONS
These results associated with a decrease in the Pseudomonas aeruginosa population can contribute in part to the beneficial effect of intermittent inhaled tobramycin on pulmonary function.
Husson
M O
MO
EA 3925, Laboratoire de Bactériologie-Hygiène, Hôpital Calmette, Boulevard du Professeur J. Leclercq, Lille, France. mohusson@chru-lille.fr
Wizla-Derambure
N
N
Turck
D
D
Gosset
P
P
Wallaert
B
B
D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D003550:Cystic Fibrosis / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D016207:Cytokines / Q000032:analysis*; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis; D016209:Interleukin-8 / Q000032:analysis; D011446:Prospective Studies; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification; D013183:Sputum / Q000187:drug effects / Q000276:immunology*; D014031:Tobramycin / Q000008:administration & dosage*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D016207:Cytokines; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D014031:Tobramycin