ES-62 is unable to modulate Toxoplasma gondii-driven Th1 responses and pathology.
ES-62, a filarial nematode-derived anti-inflammatory immunomodulator, was administered to mice in an attempt to prevent pathology associated with Toxoplasma gondii infection. The nematode product was shown to elevate mitogen and T. gondii-specific IL-10 production but was unable to inhibit Th1 responses. Consequently ES-62 could not prevent Th1 generated immunopathology.
Couper
K N
KN
Trudeau Institute Inc., Saranac Lake, New York 12983, USA.
Chen
W
W
Houston
K M
KM
Harnett
W
W
Johnson
L L
LL
D000818:Animals; D001921:Brain / Q000473:pathology; D016207:Cytokines / Q000097:blood*; D004195:Disease Models, Animal; D015801:Helminth Proteins / Q000008:administration & dosage / Q000276:immunology*; D007155:Immunologic Factors / Q000008:administration & dosage; D016753:Interleukin-10 / Q000032:analysis; D007422:Intestines / Q000473:pathology; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018417:Th1 Cells / Q000276:immunology*; D014122:Toxoplasma / Q000276:immunology*; D014124:Toxoplasmosis, Animal / Q000276:immunology* / Q000473:pathology*
D016207:Cytokines; C435884:ES-62 protein, Acanthocheilonema viteae; D015801:Helminth Proteins; D007155:Immunologic Factors; D016753:Interleukin-10