In vitro inhibitory effects of hinokitiol on proliferation of Chlamydia trachomatis.
The inhibitory effects of hinokitiol (beta-thujaplicin) on Chlamydia trachomatis D/UW-3/Cx were shown by MIC, minimum lethal concentration (MLC), and preinoculation minimal microbicidal concentration assays using HeLa 229 cells. The MIC and the MLC were both 32 microg/ml. Further evaluation of hinokitiol as a topical agent against C. trachomatis is warranted.
Yamano
Hiroaki
H
Department of Virology 1, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo, Japan 162-8640.
Yamazaki
Tsutomu
T
Sato
Kozue
K
Shiga
Sadashi
S
Hagiwara
Toshikatsu
T
Ouchi
Kazunobu
K
Kishimoto
Toshio
T
D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000633:toxicity; D002692:Chlamydia trachomatis / Q000187:drug effects* / Q000254:growth & development*; D004305:Dose-Response Relationship, Drug; D006367:HeLa Cells / Q000187:drug effects / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D039821:Monoterpenes / Q000494:pharmacology* / Q000633:toxicity; D014334:Tropolone / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000633:toxicity
D000890:Anti-Infective Agents; D039821:Monoterpenes; D014334:Tropolone; C009479:beta-thujaplicin