A supramolecular approach to multivalent target-specific MRI contrast agents for angiogenesis.
The synthesis of a cyclic peptide-Gd(III)DTPA molecule equipped with biotin is presented, yielding a well-defined multivalent MRI contrast agent after its coupling to avidin.
Dirksen
Anouk
A
Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, Eindhoven, The Netherlands.
Langereis
Sander
S
de Waal
Bas F M
BF
van Genderen
Marcel H P
MH
Hackeng
Tilman M
TM
Meijer
E W
EW
D001360:Avidin / Q000737:chemistry; D001710:Biotin / Q000737:chemistry; D003287:Contrast Media / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008958:Models, Molecular; D015394:Molecular Structure; D018919:Neovascularization, Physiologic; D017186:Titrimetry
D003287:Contrast Media; D001360:Avidin; D001710:Biotin