title: Disruption of male sexual behavior in rats by tetrahydrofurandiols (THF-diols).
abstract: The mitogenic agent that disrupts male and female sexual behavior has been isolated from corncob bedding. The disrupting activity resides in an isomeric mixture of linoleic acid derivatives with a tetrahydrofuran ring and two hydroxyl groups (THF-diols) that include 9, (12)-oxy-10, 13-dihydroxtstearic acid and 10, (13)-oxy-9, 12-dihydroxystearic acid. We examined the effects of exposure of male rats to THF-diols in drinking water on several parameters of male sexual behavior. THF-diols disrupt sexual behavior in male rats by reducing mounting and intromission frequencies. The mount, intromission and ejaculatory latencies are enhanced while the ejaculatory responses are diminished. These findings suggest that the THF-diols modulate hypothalamo-pituitary axis to regulate steroid hormone-dependent male sexual behavior.
authors.affiliation: Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
authors.forename: Shaila K
authors.initials: SK
authors.lastname: Mani
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Reyna
authors.forename: Mary A
authors.initials: MA
authors.lastname: Alejandro
authors.forename: Jan
authors.initials: J
authors.lastname: Crowley
authors.forename: Barry M
authors.initials: BM
authors.lastname: Markaverich
mesh_terms: D000818:Animals; D005663:Furans / Q000737:chemistry / Q000494:pharmacology*; D006799:Housing, Animal; D006900:Hydroxylation; D008041:Linoleic Acids / Q000494:pharmacology*; D008297:Male; D048789:Phytoestrogens / Q000009:adverse effects / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D003313:Zea mays
chemical_list: D005663:Furans; D008041:Linoleic Acids; D048789:Phytoestrogens