title: Synthesis and bioactivity of some new N-aryl/alkyl/cyclohexyl-N'-(2,3-dihydro-2-oxo-4H-benz[e][1,3,2]oxazaphosphorin-2-yl) ureas.
abstract: Several new substituted oxazaphosphorinyl urea derivatives of the type RR'P(O)NHC(O)NHR'' were synthesized from alpha-(3-chloro-4-fluoroanilino)-o-cresol by reaction with chlorides of aryl/alkyl/cyclohexyl carbamidophosphoric acids in the presence of triethylamine at 0-50 degrees C. Their significant insecticidal and antimicrobial activity and promotion of Rhizobium bacteria growth in the soil without effect on the host tissue suggests their possible commercial application as ecofriendly pesticides and antimicrobial agents.
authors.affiliation: Department of Chemistry, Sri Venkateswara University, Tirupati, India.
authors.forename: Y B
authors.initials: YB
authors.lastname: Kiran
authors.forename: D
authors.initials: D
authors.lastname: Gunasekar
authors.forename: C
authors.initials: C
authors.lastname: Devendranath Reddy
authors.forename: C
authors.initials: C
authors.lastname: Suresh Reddy
authors.forename: Kevin
authors.initials: K
authors.lastname: Tran
authors.forename: Thanh
authors.initials: T
authors.lastname: Le
authors.forename: K Darrell
authors.initials: KD
authors.lastname: Berlin
authors.forename: S
authors.initials: S
authors.lastname: Srinivasan
authors.forename: M
authors.initials: M
authors.lastname: Charitha Devi
mesh_terms: D000528:Alternaria / Q000187:drug effects; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D012831:Bombyx / Q000187:drug effects; D001517:Coleoptera / Q000187:drug effects; D007306:Insecticides / Q000138:chemical synthesis / Q000494:pharmacology; D015394:Molecular Structure; D010063:Ovum / Q000187:drug effects; D012231:Rhizobium / Q000187:drug effects; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007306:Insecticides; D014508:Urea