Comparative in vitro activities of investigational peptide deformylase inhibitor NVP LBM-415 and other agents against human mycoplasmas and ureaplasmas.
Peptide deformylase inhibitor LBM-415 and seven other drugs were tested against Mycoplasma pneumoniae (100 isolates), Mycoplasma hominis (20 isolates), Mycoplasma fermentans (10 isolates), and Ureaplasma species (50 isolates). LBM-415 was active against M. pneumoniae (MICs, <or=0.008 microg/ml). It showed no activity against M. hominis and M. fermentans and modest activity against Ureaplasma spp.
Waites
Ken B
KB
Department of Pathology, WP 230, 619 19th Street South, Birmingham, AL 35249, USA. waites@path.uab.edu
Reddy
Nipun B
NB
Crabb
Donna M
DM
Duffy
Lynn B
LB
D000581:Amidohydrolases / Q000037:antagonists & inhibitors*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009174:Mycoplasma / Q000145:classification / Q000187:drug effects*; D016858:Mycoplasma fermentans / Q000187:drug effects; D019535:Mycoplasma hominis / Q000187:drug effects; D009177:Mycoplasma pneumoniae / Q000187:drug effects; D011480:Protease Inhibitors / Q000494:pharmacology*; D014509:Ureaplasma / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D011480:Protease Inhibitors; D000581:Amidohydrolases; C084507:peptide deformylase