title: Fiber-optic nanosensors for single-cell monitoring.
abstract: This article is an overview of the fabrication, operating principles, and applications of fiber-optic nanobiosensors with the capability of in-vivo analysis at the single-cell level. Recently, the cross-disciplinary integration of nanotechnology, biology, and photonics has been revolutionizing important areas in molecular biology, especially diagnostics and therapy at the molecular and cellular level. Fiber-optic nanobiosensors are a unique class of biosensor that enable analytical measurements in individual living cells and the probing of individual chemical species in specific locations within a cell. This article provides a review of the research performed in our laboratory and discusses the usefulness and potential of this nanotechnology-based biosensor system in biological research and its applications to biomonitoring of individual cells.
authors.affiliation: Oak Ridge National Laboratory, Advanced Biomedical Science and Technology Group, Oak Ridge, TN 37831-6101, USA. vodinht@ornl.gov
authors.forename: Tuan
authors.initials: T
authors.lastname: Vo-Dinh
authors.forename: Paul
authors.initials: P
authors.lastname: Kasili
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods*; D005336:Fiber Optic Technology; D006801:Humans; D036103:Nanotechnology / Q000295:instrumentation* / Q000379:methods*; D055100:Optical Fibers; D012680:Sensitivity and Specificity