title: [The role of preventing nitric oxide deficiency in the antihypertensive effect of adaptation to hypoxia].
abstract: Shortage of endothelial nitric oxide (NO) manifested as decreased daily urinary excretion of nitrate and nitrite as well as attenuated endothelium-dependent relaxation of conduit and resistance vessels progresses with age-related increase of blood pressure (BP) in stroke-prone spontaneously hypertensive rats (SHRSP). Simultaneous NO-dependent suppression of vascular contractions is, apparently, due to the inducible NO synthase activity in vascular smooth muscle specific for spontaneously hypertensive rat. Adaptation of rats to hypobaric hypoxia initiated at early hypertensive stage (at the age of 5-6 weeks) decelerates hypertension progress. The antihypertensive effect of the adaptation was accompanied by stimulation of endothelial NO synthesis and prevention of impaired NO-dependent response in isolated blood vessels. Nitric oxide stores were formed in the vascular wall of SHRSP and WKY rats at the same time. The obtained data indicate a significant role of correction of endothelial NO deficiency in the antihypertensive effect of adaptation to hypoxia.
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Mashina
authors.forename: B V
authors.initials: BV
authors.lastname: Smirin
authors.forename: D A
authors.initials: DA
authors.lastname: Pokidyshev
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Malyshev
authors.forename: N P
authors.initials: NP
authors.lastname: Liamina
authors.forename: V N
authors.initials: VN
authors.lastname: Senchikin
authors.forename: Kh M
authors.initials: KhM
authors.lastname: Markov
authors.forename: E B
authors.initials: EB
authors.lastname: Manukhin
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000693:Anaerobiosis; D000818:Animals; D004730:Endothelium, Vascular / Q000378:metabolism*; D006973:Hypertension / Q000378:metabolism / Q000517:prevention & control*; D009566:Nitrates / Q000652:urine; D009569:Nitric Oxide / Q000172:deficiency* / Q000378:metabolism; D009573:Nitrites / Q000652:urine; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
chemical_list: D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide