In vitro and in vivo activities of DA-7867, a new oxazolidinone, against aerobic gram-positive bacteria.
In vitro and in vivo activities of DA-7867 were assessed against methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and penicillin-resistant Streptococcus pneumoniae. All isolates were inhibited by DA-7867 at <or=0.78 microg/ml, a four-times-lower concentration than that of inhibition by linezolid. For murine infection models, DA-7867 also exhibited greater efficacy than linezolid against all isolates tested.
Yoon
Eun Jeong
EJ
Department of Microbiology, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, San 56-1, Shillim-9 dong, Kwanak-gu, Seoul 151-742, Korea.
Jo
Yeong Woo
YW
Choi
Sung Hak
SH
Lee
Tae Ho
TH
Rhee
Jae Keol
JK
Yoo
Moohi
M
Shim
Mi Ja
MJ
Choi
Eung Chil
EC
D000081:Acetamides / Q000494:pharmacology / Q000627:therapeutic use; D000332:Aerobiosis; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D024881:Drug Resistance, Bacterial; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D006095:Gram-Positive Cocci / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D000069349:Linezolid; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000494:pharmacology* / Q000627:therapeutic use*
D000081:Acetamides; D000890:Anti-Infective Agents; C480487:DA-7867; D023303:Oxazolidinones; D000069349:Linezolid