title: Recent advances and current developments in tissue scaffolding.
abstract: A bio-scaffold can be broadly termed as a structure used to substitute an organ either permanently or temporarily to restore functionality. The material that can be used varies with the application intended. Tissue engineering is one such application demanding certain requirements to be met before it is applied. One of the applications in tissue engineering is the tissue scaffold, which provides either a permanent or temporary support to the damaged tissues/organ until the functionalities are restored. A biomaterial can exhibit specific interactions with cells that will lead to stereotyped responses. The use of a particular material and morphology depends on various factors such as osteoinduction, osteoconduction, angiogenesis, growth rates of cells and degradation rate of the material in case of temporary scaffolds, etc. The current work reviews the state of art in tissue scaffolds and focuses on permanent scaffold materials and applications with a brief overview of temporary scaffold materials and their disadvantages.
authors.affiliation: School of Mechanical, Manufacturing and Medical Engineering, Queensland University of Technology, Brisbane, Australia. y.prasad@qut.edu.au
authors.forename: Prasad K D V
authors.initials: PK
authors.lastname: Yarlagadda
authors.forename: Margam
authors.initials: M
authors.lastname: Chandrasekharan
authors.forename: John Yong Ming
authors.initials: JY
authors.lastname: Shyan
mesh_terms: D000818:Animals; D021522:Bioartificial Organs; D001672:Biocompatible Materials / Q000737:chemistry*; D001698:Biomedical Engineering / Q000379:methods*; D001842:Bone and Bones; D002417:Cattle; D019070:Cell Lineage; D003094:Collagen / Q000737:chemistry; D003198:Computer Simulation; D006801:Humans; D008567:Membranes, Artificial; D018613:Microscopy, Confocal; D008855:Microscopy, Electron, Scanning; D011108:Polymers; D013234:Stem Cells / Q000166:cytology; D023822:Tissue Engineering / Q000379:methods* / Q000639:trends; D014025:Titanium / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; D011108:Polymers; D003094:Collagen; D014025:Titanium