Microwave-assisted synthesis of N,N'-diaryl cyanoguanidines.
[reaction: see text] A mild, efficient, and high-yielding method for the synthesis of N,N'-diaryl cyanoguanidines from their corresponding thioureas under microwave-assisted conditions is described. A series of cyanoguanidines were synthesized containing both electron-donating and electron-withdrawing substituents. The reactions were facilitated by the use of polar solvents along with moderate temperatures.
Hamilton
Sean K
SK
Department of Research, Guilford Pharmaceuticals, Inc., Baltimore, Maryland 21224, USA.
Wilkinson
Doug E
DE
Hamilton
Gregory S
GS
Wu
Yong-Qian
YQ
D002384:Catalysis; D006146:Guanidines / Q000138:chemical synthesis*; D008872:Microwaves; D015394:Molecular Structure; D013440:Sulfides / Q000138:chemical synthesis; D013696:Temperature
D006146:Guanidines; D013440:Sulfides; C004711:dicyandiamido