[Cardiovascular manifestations in rheumatoid arthritis].
Rheumatoid arthritis (RA) is a chronic inflammatory disease, characterized by a polyarticular joint inflammation which eventually leads to joint destruction and general disability. Besides these polyarticular manifestations, several systemic immune phenomena have been described. An increased mortality in RA patients is evident and is mainly caused by an increased cardiovascular risk. The correlation between disease activity and mortality highlighted the important role of the systemic inflammatory reaction in induction and progression of vascular damaging processes. Endothelial dysfunction and vascular inflammation are important, mechanisms in atherosclerosis and induced by conventional risk factors and systemic inflammation. It has been shown that the deleterious influence of conventional risk factors is aggravated by inflammatory mediators, mainly by pro-inflammatory cytokines. In addition, certain inflammatory mediators exert damaging effects to blood vessels. Especially CRP, merely considered as a risk indicating parameter in the past, has attracted remarkable attention. Also certain RA specific immune phenomena are of considerable proatherosclerotic potential. At least in part, they could be responsible for the excess mortality in RA patients. The newer TNFalpha blocking agents interfere with different mechanisms responsible for induction and perpetuation of atherosclerotic processes. Time will show whether they make a remarkable impact on the cardiovascular mortality in RA patients.
Moritz
F
F
Center of Experimental Rheumatology and WHO Collaborating Center for Molecular Biology and Novel Therapeutic Strategies, University Hospital, Zürich, Switzerland, Gloriastr. 25, 8091, Zürich, Switzerland.
Wagner
U
U
Distler
O
O
Seidel
W
W
Gay
S
S
Häntzschel
H
H
D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000401:mortality*; D002318:Cardiovascular Diseases / Q000276:immunology / Q000401:mortality*; D002986:Clinical Trials as Topic; D015897:Comorbidity; D006801:Humans; D038622:Internationality; D015995:Prevalence; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors