title: Combined cataract and glaucoma surgery with mitomycin C: phacoemulsification-trabeculectomy compared to phacoemulsification-deep sclerectomy.
abstract: OBJECTIVE
  To compare outcomes of phacoemulsification combined with trabeculectomy (PT) or deep sclerectomy (PDS) with intraoperative mitomycin C (MMC) application.
  
  
  METHODS
  Non-randomised, consecutive, retrospective comparative study. 97 eyes of 97 patients (59 PDS, 38 PT) undergoing combined surgery with intraoperative MMC (0.1-0.4 mg/ml for 1-3 minutes) were identified for inclusion in the study.
  
  
  RESULTS
  The probability of maintaining intraocular pressure (IOP) below 19 mm Hg and 15 mm Hg, with a 30% drop from preoperative IOP and without additional medication, 1 year after surgery were 77.6% (95% CI: 67 to 90) and 71.5% (60 to 85) for the PDS group and 89.5% (80 to 99) and 89.5 (80 to 99) for the PT group, respectively, and these differences were not statistically significant (p>0.05, log rank test). After excluding ocular co-morbidity no differences were observed in the improvement of visual acuity between the two groups. There were no major differences in the complication rates except that delayed bleb leaks were seen in seven eyes (18.4%) of the PT group (p = 0.004).
  
  
  CONCLUSIONS
  In this study, no statistically significant difference was found in the IOP and visual outcomes between PDS and PT. A significantly higher frequency of late bleb leaks after PT was observed.
authors.affiliation: West Yorkshire Rotation, Clarendon Wing, Leeds General Infirmary, Leeds, UK.
authors.forename: C L
authors.initials: CL
authors.lastname: Funnell
authors.forename: M
authors.initials: M
authors.lastname: Clowes
authors.forename: N
authors.initials: N
authors.lastname: Anand
mesh_terms: D000368:Aged; D002386:Cataract / Q000150:complications; D003131:Combined Modality Therapy; D005260:Female; D005901:Glaucoma / Q000150:complications / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D007430:Intraoperative Care / Q000379:methods; D008297:Male; D016685:Mitomycin / Q000627:therapeutic use*; D019384:Nucleic Acid Synthesis Inhibitors / Q000627:therapeutic use; D018918:Phacoemulsification / Q000009:adverse effects; D011182:Postoperative Care / Q000379:methods; D012189:Retrospective Studies; D012590:Sclera / Q000601:surgery*; D016019:Survival Analysis; D014130:Trabeculectomy / Q000009:adverse effects; D016896:Treatment Outcome; D014792:Visual Acuity
chemical_list: D019384:Nucleic Acid Synthesis Inhibitors; D016685:Mitomycin