title: [The pathological changes of abdominal and peripheral arteries in familial hypercholesterolemia--the result of high-resolution color Doppler ultrasonography].
abstract: OBJECTIVE
  To explore changes of abdominal and peripheral arteries in familial hypercholesterolemia (FH) patients with definite etiopathogenesis by high-resolution color Doppler ultrasound; to identify the arteriosclerotic progression of FH patients and offer the valuable foundation for clinic treatment.
  
  
  METHODS
  Observe the interior-media thickness (IMT), stenotic degree and hemodynamics change of arteries by ultrasonography in six children in five family constellations (index case) and six normal controls.
  
  
  RESULTS
  There was significant difference between FH and control group in IMT of the posterior wall in left external carotid artery (origination), right common carotid artery (approaching piece) and IMT of the anterior and posterior wall right common carotid artery (intermediate piece) (P = 0.015). Significant thickening of IMT was not observed in vertebral arteries, subclavicular arteries, abdominal aorta, renal arteries, iliac arteries and popliteal arteries both in FH and control group.
  
  
  CONCLUSIONS
  The arteriosclerotic aggravation of FH patients could not be revealed by the level of the blood fat, but could be revealed correctly by ultrasonography. It is possible to provide significant foundation for individualized treatment of FH patients by regular non-invasive ultrasonography.
authors.affiliation: Department of Ultrasonic Diagnosis, Beijing Anzhen Hospital, Capital University of Medical Sciences, Beijing 100029, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Yong
authors.forename: Hui
authors.initials: H
authors.lastname: Sun
authors.forename: Zhi-an
authors.initials: ZA
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: Lin
authors.forename: Lu-ya
authors.initials: LY
authors.lastname: Wang
mesh_terms: D034841:Abdominal Cavity / Q000098:blood supply; D000293:Adolescent; D000328:Adult; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D008297:Male; D010375:Pedigree; D017354:Point Mutation; D011973:Receptors, LDL / Q000235:genetics; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology*; D018615:Ultrasonography, Doppler, Color; D055815:Young Adult
chemical_list: D011973:Receptors, LDL