[Study on space flight-mutants of Monascus purpureus using Random Amplified Polymorphic DNA].
OBJECTIVE
To study the mechanism of microbial mutation in aerospace.


METHODS
Random Amplified Polymorphic DNA (RAPD) was used to analyze the polymorphism of high Lovastatin-producing mutants.


RESULTS
Variations occurred in genomes of these mutants.


CONCLUSIONS
The high Lovastatin producibility of the mutants is due to the variation of genomes, therefore the microbial mutation in the aerospace is achieved via the variation of hereditary genes in the microbes.
Yin
Hong
H
Lu
Wei
W
Xie
Shen-meng
SM
D004271:DNA, Fungal / Q000235:genetics*; D004783:Environmental Microbiology; D008148:Lovastatin / Q000235:genetics / Q000378:metabolism*; D032741:Monascus / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D009154:Mutation; D019105:Random Amplified Polymorphic DNA Technique; D013026:Space Flight; D014893:Weightlessness
D004271:DNA, Fungal; D008148:Lovastatin