title: High beta-carotene and beta-cryptoxanthin are associated with low pulse wave velocity.
abstract: Antioxidants are potentially beneficial in preventing vascular complications in diabetes because oxidative stress would be enhanced in such a condition and play an important role in vascular disorders. This study aimed to investigate whether brachial-ankle pulse wave velocity (baPWV) would be lower in the presence of high serum carotenoid concentrations stratified according to the glycemic state. A total of 297 men and 579 women between 30 and 70 years of age were analyzed cross-sectionally. Multivariate adjusted mean of baPWV in the highest tertile for beta-carotene (1386 cm/s) was lower than that in the lowest tertile (1432 cm/s) and that in the highest tertile for beta-cryptoxanthin (1382 cm/s) was lower than that in the middle tertile (1424 cm/s) in the case of normal fasting glucose. Similar inverse associations were observed in a group that included subjects with both impaired fasting glucose and diabetes, however, without statistical significance. The highest tertile of carotenoids was associated with a low risk for high baPWV (> or =1680 cm/s). Age, sex and glycemic state adjusted odds ratio was 0.35 (95% CI 0.20-0.60) for beta-carotene and 0.45 (0.27-0.77) for beta-cryptoxanthin. Multivariate adjustment did not alter the results. In conclusion, an inverse association of baPWV with beta-carotene and beta-cryptoxanthin was observed independently of the glycemic state.
authors.affiliation: Department of Hygiene, Hamamatsu University School of Medicine, Japan. miekons@nils.go.jp
authors.forename: Mieko
authors.initials: M
authors.lastname: Nakamura
authors.forename: Minoru
authors.initials: M
authors.lastname: Sugiura
authors.forename: Nobuo
authors.initials: N
authors.lastname: Aoki
mesh_terms: D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000097:blood / Q000503:physiopathology*; D015415:Biomarkers / Q000097:blood; D001783:Blood Flow Velocity / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism; D001916:Brachial Artery / Q000503:physiopathology; D003430:Cross-Sectional Studies; D065366:Cryptoxanthins; D003920:Diabetes Mellitus / Q000097:blood / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011673:Pulsatile Flow / Q000502:physiology*; D012189:Retrospective Studies; D016909:Tibial Arteries / Q000503:physiopathology; D024341:Xanthophylls; D019207:beta Carotene / Q000031:analogs & derivatives* / Q000097:blood*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D065366:Cryptoxanthins; D024341:Xanthophylls; D019207:beta Carotene