title: [The biochemical changes of hippocampus in patients before and after denture restoration: a preliminary 1H-magnetic resonance spectroscopy study].
abstract: OBJECTIVE
  To study the effects of reconstruction of lost occlusal support on the biochemical changes of nervous system.
  
  
  METHODS
  The changes of central nervous system metabolic compounds within hippocampus body were measured with proton magnetic resonance spectroscopy ((1)HMRS) before and after denture restoration (six weeks) in seven patients with prolonged loss of occlusal support.
  
  
  RESULTS
  (1)HMRS indicated that Cho/Cr decreased by 11.9% (P < 0.05) six weeks after denture restoration, MI/Cr decreased by 28.8% (P < 0.05), and NAA/CR increased by 4.8% (P > 0.05) within hippocampus body.
  
  
  CONCLUSIONS
  Recovery of occlusal support facilitates improvement of neuron functions in patients' hippocampus, which may help improve the functions of nervous system.
authors.affiliation: Department of Stomatology, Beijing Anzhen Hospital, Capital University of Medical Sciences, Beijing 100029, China.
authors.forename: Qing-song
authors.initials: QS
authors.lastname: Jiang
authors.forename: Ting
authors.initials: T
authors.lastname: Jiang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Jin
authors.forename: Hai-lan
authors.initials: HL
authors.lastname: Feng
authors.forename: Ya-wei
authors.initials: YW
authors.lastname: Zeng
authors.forename: Jian
authors.initials: J
authors.lastname: Li
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003832:Denture, Partial, Removable; D005260:Female; D006624:Hippocampus / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D016388:Tooth Loss / Q000378:metabolism* / Q000628:therapy