title: The effect of omeprazole pre-treatment on rafts formed by reflux suppressant tablets containing alginate.
abstract: Alginate-based reflux suppressant preparations provide symptom relief by forming a physical barrier on top of the stomach contents in the form of a neutral floating gel or raft. This study investigated whether reduced acidity in the stomach brought about by omeprazole pre-treatment affected the formation and gastric residence time of alginate rafts. It was a balanced, cross-over study in 12 healthy non-patient volunteers following a single dose of two indium-111-labelled alginate tablets in the presence or absence of 3 days' pre-treatment with omeprazole. Raft formation and gastric residence, in the presence of a technetium-99m-labelled meal, were assessed by gamma scintigraphy for 3 h after alginate tablet administration. The relative raft-forming ability of alginate tablets after omeprazole compared with alginate tablets alone was 0.950 with 95% confidence intervals of 0.882 and 1.018. Pre-treatment and co-administration with omeprazole has no significant effect on the raft-forming ability of alginate tablets.
authors.affiliation: Reckitt Benckiser Healthcare (UK) Ltd, Hull, UK. peter.dettmar@technostics.com
authors.forename: P W
authors.initials: PW
authors.lastname: Dettmar
authors.forename: S L
authors.initials: SL
authors.lastname: Little
authors.forename: T
authors.initials: T
authors.lastname: Baxter
mesh_terms: D000328:Adult; D000464:Alginates / Q000737:chemistry / Q000494:pharmacology*; D000536:Aluminum Hydroxide / Q000737:chemistry; D000863:Antacids / Q000008:administration & dosage / Q000494:pharmacology*; D019540:Area Under Curve; D018592:Cross-Over Studies; D004338:Drug Combinations; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D020723:Glucuronic Acid / Q000737:chemistry; D006356:Heartburn / Q000188:drug therapy; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D007205:Indium Radioisotopes / Q000494:pharmacology; D008297:Male; D009853:Omeprazole / Q000494:pharmacology*; D011877:Radionuclide Imaging; D012824:Silicic Acid / Q000737:chemistry; D017693:Sodium Bicarbonate / Q000737:chemistry; D013997:Time Factors
chemical_list: D000464:Alginates; D000863:Antacids; D004338:Drug Combinations; D006603:Hexuronic Acids; D007205:Indium Radioisotopes; D012824:Silicic Acid; D000536:Aluminum Hydroxide; C007829:alginate, aluminium hydroxide, magnesium trisilicate, sodium bicarbonate drug combination; D020723:Glucuronic Acid; D017693:Sodium Bicarbonate; D009853:Omeprazole