Levofloxacin disposition over time in aqueous humor of patients undergoing cataract surgery.
The ocular disposition of levofloxacin in patients receiving two 500-mg oral doses 10 h apart before cataract surgery was assessed with the intent of defining drug ocular exposure over time. The mean aqueous humor concentrations persisted above 1.5 mg/liter between 1.5 and 6.0 h after the second dose, with average aqueous-to-plasma ratios ranging between 0.33 and 0.57. This favorable ocular disposition provides support for trials of systemic levofloxacin for prophylaxis of postoperative endophthalmitis in selected patients or as adjunctive therapy for the treatment of this potentially devastating infective complication.
Pea
Federico
F
Institute of Clinical Pharmacology and Toxicology, DPMSC, University of Udine, P. le S. Maria della Misericordia 3, 33100 Udine, Italy. federico.pea@med.uniud.it
Ferrari
Ettore
E
Pavan
Federica
F
Roman-Pognuz
Derri
D
Bandello
Francesco
F
Furlanut
Mario
M
D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001082:Aqueous Humor / Q000378:metabolism*; D002387:Cataract Extraction / Q000009:adverse effects; D009877:Endophthalmitis / Q000517:prevention & control; D005123:Eye / Q000378:metabolism; D005260:Female; D006801:Humans; D064704:Levofloxacin; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D064704:Levofloxacin; D015242:Ofloxacin