Anti-inflammatory activity of Sapindus trifoliatus Linn.
Anti-inflammatory activity of the ethanolic extract of the seeds of Sapindus trifoliatus Linn. was studied in wister rats using the carrageenan induced left hind paw edema, carrageenan induced pleurisy and cotton pellet induced granuloma model. The ethanolic extract (150 mg/kg, p.o.) produced the inhibition of carrageenan induced rat paw edema. It also showed an inhibitory effect on leukocyte migration and a reduction on the pleural exudates as well as reduction on the granuloma weight in the cotton pellet granuloma method. The results indicated that the ethanolic extract produced significant (P < 0.001) anti-inflammatory activity when compared with the standard and untreated control.
Arul
B
B
Department of Pharmaceutics, Vinayaka Mission's College of Pharmacy, Yercaud Main Road, Salem-636008, Tamil Nadu, India. arul1971@yahoo.com
Kothai
R
R
Jacob
Philip
P
Sangameswaran
B
B
Sureshkumar
K
K
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002351:Carrageenan; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005534:Foot Diseases / Q000139:chemically induced; D006099:Granuloma / Q000139:chemically induced / Q000188:drug therapy; D007249:Inflammation / Q000139:chemically induced* / Q000188:drug therapy*; D007958:Leukocyte Count; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D010998:Pleurisy / Q000139:chemically induced / Q000188:drug therapy; D051381:Rats; D017208:Rats, Wistar; D032127:Sapindus
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D002351:Carrageenan