title: Microbial transformation of 20(S)-protopanaxatriol by Mucor spinosus.
abstract: Microbial biotransformation of 20(S)-protopanaxatriol (1) by the fungus Mucor spinosus (AS 3.3450) yielded four new metabolites, the structures of which were determined to be 12-oxo-15alpha-hydroxyl-20(S)-protopanaxatriol (2), 27-hydroxyl-20(S)-protopanaxatriol (3), 12-oxo-26-hydroxyl-20(S)-protopanaxatriol (4), and 12-oxo-27-hydroxyl-20(S)-protopanaxatriol (5), respectively, on the basis of their chemical and spectroscopic data. All the new metabolites, as well as the substrate, had significant cytotoxic effects on HL-60 cells (human leukemia cells).
authors.affiliation: The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xueyuan Road #38, Beijing 100083, People's Republic of China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Tian
authors.forename: Hongzhu
authors.initials: H
authors.lastname: Guo
authors.forename: Jian
authors.initials: J
authors.lastname: Han
authors.forename: Dean
authors.initials: D
authors.lastname: Guo
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D001711:Biotransformation; D004354:Drug Screening Assays, Antitumor; D015394:Molecular Structure; D009089:Mucor / Q000378:metabolism*; D012502:Sapogenins / Q000378:metabolism* / Q000494:pharmacology; D013237:Stereoisomerism; D014315:Triterpenes / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D012502:Sapogenins; D014315:Triterpenes; C081552:protopanaxatriol