title: Determination of relative bioavailability of zinc in a petit suisse cheese using weight gain and bone zinc content in rats as markers.
abstract: The aim of the study was to determine the relative bioavailability of zinc gluconate stabilized with glycine in a Petit Suisse cheese from an infant dessert. Weight gain and bone zinc content were the nutritional responses evaluated for the diets of different zinc content: 2 ppm (basal) and 5, 10, and 30 ppm from zinc gluconate stabilized with glycine and zinc sulfate. Nonlinear regression analysis of the fitted curves for weight gain determined a relative zinc bioavailability of 100% for the Y<I->max ratio and 96% for Ymax/t1/2 ratio for zinc gluconate stabilized with glycine (R2=0.7996 for zinc sulfate and 0.8665 for zinc gluconate stabilized with glycine). The slope ratio analysis from linear regression of femur zinc determined a relative zinc bioavailability of 93% for zinc gluconate stabilized with glycine (R<I+>2=0.8693 for zinc sulfate and 0.8307 for zinc gluconate stabilized with glycine). Zinc gluconate stabilized with glycine has similar bioavailability as zinc sulfate in a Petit Suisse cheese nutritional matrix, with the advantage that the stabilized compound does not modify the sensorial characteristics of the fortified cheese.
authors.affiliation: Radioisotope Laboratory and Stable Isotope Laboratory Applied to Biology and Medicine, Physics Department, School of Pharmacy and Biochemistry, University of Buenos Aires. Junín 956 1113-Ciudad de Buenos Aires, Argentina.
authors.forename: J
authors.initials: J
authors.lastname: Salgueiro
authors.forename: N
authors.initials: N
authors.lastname: Leonardi
authors.forename: M
authors.initials: M
authors.lastname: Zubillaga
authors.forename: R
authors.initials: R
authors.lastname: Weill
authors.forename: C
authors.initials: C
authors.lastname: Goldman
authors.forename: G
authors.initials: G
authors.lastname: Calmanovici
authors.forename: A
authors.initials: A
authors.lastname: Barrado
authors.forename: M Martinez
authors.initials: MM
authors.lastname: Sarrasague
authors.forename: J
authors.initials: J
authors.lastname: Boccio
mesh_terms: D000818:Animals; D001682:Biological Availability; D015415:Biomarkers; D002611:Cheese / Q000032:analysis*; D005269:Femur / Q000033:anatomy & histology / Q000737:chemistry; D005942:Gluconates / Q000008:administration & dosage; D005998:Glycine / Q000008:administration & dosage; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D015430:Weight Gain / Q000187:drug effects*; D015032:Zinc / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019287:Zinc Sulfate / Q000008:administration & dosage
chemical_list: D015415:Biomarkers; D005942:Gluconates; C437626:zinc gluconate glycine; D019287:Zinc Sulfate; D015032:Zinc; D005998:Glycine