title: A pathophysiological paradigm for the therapy of psychiatric disease.
abstract: Despite enormous progress in fundamental knowledge in neuroscience, no revolutionary therapies in psychiatry (and neurology) have emerged in the past ten years. Most drugs alleviate symptoms, rather than restoring the 'set point' of brain function from a pathological position to a more normal one. We propose a hypothesis-driven, systems-level approach to drug discovery and development that is based on pathophysiology and which uses new animal models.
authors.affiliation: Institut de Recherches Internationales Servier (IRIS), 11 rue des Moulineaux, Suresnes 92150, France.
authors.forename: Michael
authors.initials: M
authors.lastname: Spedding
authors.forename: Thérèse
authors.initials: T
authors.lastname: Jay
authors.forename: Jorge
authors.initials: J
authors.lastname: Costa e Silva
authors.forename: Laurent
authors.initials: L
authors.lastname: Perret
mesh_terms: D000818:Animals; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy* / Q000503:physiopathology*; D011619:Psychotropic Drugs / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D011619:Psychotropic Drugs