title: Multicentric osteosarcoma presenting as retrobulbar mass: a diagnostic enigma.
abstract: Osteosarcoma is the most common primary malignant bone tumor of children and adolescents. It often presents as a solitary lesion; multicentric osteosarcoma with synchronous lesions occurring at multiple skeletal sites is very rare. We report a 9-year-old boy with multicentric osteosarcoma who presented with a left retrobulbar non-sclerotic mass. The multiple lesions in bone were mostly non-sclerotic on radiological examination except for a single lesion in the left tibia. Biopsy of the retrobulbar mass showed an unclassifiable poorly differentiated malignant tumor. Marrow aspiration smears showed many large, often segregated, round cells that expressed NB84a. However, trephine biopsy showed the formation of tumoral osteoid by the malignant cells, finally permitting the definitive diagnosis of osteosarcoma to be made. A hypertetraploid clone with complex structural abnormalities was demonstrated by cytogenetic study.
authors.affiliation: Department of Pathology, Queen Elizabeth Hospital, Hong Kong. kfwong@ha.org.hk
authors.forename: K F
authors.initials: KF
authors.lastname: Wong
authors.forename: S J
authors.initials: SJ
authors.lastname: Shu
authors.forename: I S C
authors.initials: IS
authors.lastname: Luk
authors.forename: H L
authors.initials: HL
authors.lastname: Yuen
authors.forename: J N S
authors.initials: JN
authors.lastname: Leung
authors.forename: J K C
authors.initials: JK
authors.lastname: Chan
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D001859:Bone Neoplasms / Q000235:genetics / Q000473:pathology*; D002648:Child; D020732:Cytogenetic Analysis; D003937:Diagnosis, Differential; D005134:Eye Neoplasms / Q000235:genetics / Q000473:pathology* / Q000556:secondary*; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000473:pathology*; D012516:Osteosarcoma / Q000235:genetics / Q000473:pathology* / Q000556:secondary*; D014057:Tomography, X-Ray Computed