[Experimental rationale for possible clinical use of biodialysis].
At biodialysis, the bloods of a patient and a donor simultaneously pass through the individual mass exchangers. The cavities of the dialyzing fluid of both mass exchangers hydraulically interconnected with recurculating transport medium. The metabolites accumulating in the patient's blood pass through the membrane to the transport medium and then the second membrane to the donor's blood and they are eliminated via his/her liver and kidney. At the same time, regression occurs: the substances required for normal vital activity move from the donor's body to the patient's one. Experiments on pigs in one of which both kidneys were removed yielded clearances of major toxic metabolites by approximately 2 times less than that at routine dialysis. Daily sessions of biodialysis ensured a satisfactory state and stable levels of metabolites. At biodialysis, the state did not deteriorate. In the other series of experiments, choledochus was ligated in one of the pigs and sessions of biodialysis were initiated following 24 hours. Daily sessions could achieve stabilization of the level of bilirubin within 135 micromol/l. In the donor pig, the level of bilirubin slightly increased. Its condition remained to be satisfactory.
Maksimenko
V A
VA
Eventov
V L
VL
Nikoda
V V
VV
Zhidkov
I L
IL
Shishlo
L A
LA
Siniutin
A A
AA
Gotye
S V
SV
D000818:Animals; D001663:Bilirubin / Q000097:blood; D017093:Liver Failure / Q000628:therapy*; D006435:Renal Dialysis / Q000379:methods*; D051437:Renal Insufficiency / Q000628:therapy*; D016060:Sorption Detoxification / Q000379:methods*; D013552:Swine
D001663:Bilirubin