In vitro activity and killing effect of citropin 1.1 against gram-positive pathogens causing skin and soft tissue infections.
The in vitro activity of citropin 1.1 against gram-positive cocci was measured by MIC, minimal bactericidal concentration, time-kill studies, and a checkerboard titration method. Streptococci and staphylococci were inhibited at concentrations between 1 and 16 mg/liter, respectively. Enterococci showed less susceptibility. Synergy was demonstrated when citropin 1.1 was combined with clarithromycin and doxycycline.
Giacometti
Andrea
A
Institute of Infectious Diseases and Public Health, c/o Ospedale Regionale, via Conca, 71, Ancona, I-60020, Italy. anconacmi@interfree.it
Cirioni
Oscar
O
Kamysz
Wojciech
W
Silvestri
Carmela
C
Del Prete
Maria Simona
MS
Licci
Alberto
A
D'Amato
Giuseppina
G
Łukasiak
Jerzy
J
Scalise
Giorgio
G
D029845:Amphibian Proteins / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D015169:Colony Count, Microbial; D004347:Drug Interactions; D024881:Drug Resistance, Bacterial; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology; D006095:Gram-Positive Cocci / Q000187:drug effects* / Q000254:growth & development*; D006801:Humans; D008826:Microbial Sensitivity Tests; D017192:Skin Diseases, Bacterial / Q000382:microbiology*; D018461:Soft Tissue Infections / Q000382:microbiology*
D029845:Amphibian Proteins; D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; C121829:citropin 1.1 protein, Litoria