Successful treatment of Fusarium keratitis with cornea transplantation and topical and systemic voriconazole.
A case of invasive Fusarium keratitis in a previously healthy male patient was treated successfully with cornea transplantation and systemic and topical voriconazole after treatment failure with topical amphotericin B and systemic itraconazole. Topical voriconazole was well tolerated, and, in conjunction with the oral administration, it resulted in a high level of the drug in the anterior chamber of the eye (which was 160% of the plasma drug level).
Klont
Rocus R
RR
Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. r.klont@mmb.umcn.nl
Eggink
Cathrien A
CA
Rijs
Antonius J M M
AJ
Wesseling
Pieter
P
Verweij
Paul E
PE
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D003315:Cornea / Q000473:pathology; D016039:Corneal Transplantation; D005670:Fusarium / Q000302:isolation & purification*; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D007634:Keratitis / Q000382:microbiology* / Q000628:therapy*; D008297:Male; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology; D011743:Pyrimidines / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D017964:Itraconazole; D000666:Amphotericin B; D065819:Voriconazole