title: [The protector properties of a pseudopeptide drug ingamine studied on a model of bronchospasm in guinea pigs].
abstract: The original pseudopeptide drug ingamine (4-[N-[2-(imidazol-4-yl)ethyl]-carbamoyl] butyric acid) was studied on the traditional model of antigen-induced bronchospasm in actively sensitized guinea pigs. The drug was introduced using various methods (by inhalation, via intragastric tube, and by intraperitoneal injections) in a range of doses (20, 50, 150, or 500 mg/kg). The new drug exhibited a pronounced dose-dependent protector action for all ways of introduction, but the most significant effect was observed upon inhalation, whereby the degree of bronchospasm inhibition exceeded 80%. In comparison to the reference drug sodium cromoglycate, ingamine (in equimolar doses) showed a higher activity with respect to the antigen-dependent bronchospasmic reactions. It can be expected that ingamine will provide for the effective treatment of bronchial obstruction under clinical conditions.
authors.forename: V L
authors.initials: VL
authors.lastname: Kovaleva
authors.forename: V E
authors.initials: VE
authors.lastname: Nebol'sin
authors.forename: A A
authors.initials: AA
authors.lastname: Karabinenko
authors.forename: G A
authors.initials: GA
authors.lastname: Zheltukhina
authors.forename: D B
authors.initials: DB
authors.lastname: Uteshev
mesh_terms: D000818:Animals; D016535:Bronchial Hyperreactivity / Q000188:drug therapy / Q000503:physiopathology; D001986:Bronchial Spasm / Q000188:drug therapy* / Q000503:physiopathology; D016084:Bronchoconstriction / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D008297:Male
chemical_list: C473189:N-glutarylhistamine; D006632:Histamine