Repetitive transcranial magnetic stimulation for treating medication-resistant depression in Taiwan: a preliminary study.
BACKGROUND
We conducted an open trial to evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS) in medication-resistant depression. This is the first study in Taiwan of rTMS for the treatment of depression.


METHODS
A 2-week regimen of rTMS (100% of motor threshold, 5 Hz, 8 sec, 40 trains/20 min/day, 10 weekdays) applied to the left dorsolateral prefrontal cortex was administered to 11 patients with medication-resistant depression.


RESULTS
Ten subjects completed 2 weeks' treatment with rTMS. Scores on the 21-item Hamilton Depression Rating Scale (HAM-D21) and Beck Depression Inventory decreased by 48% and 28%, respectively. Five patients were clinical responders (> or = 50% reduction in HAM-D21 score): 2 of these were in complete remission (HAM-D21 score < or = 7). Five patients were less responsive: 2 of these were partial responders (20-49% reduction in HAM-D21 score), whereas 3 did not improve. Younger versus older age was identified as a potential predictor of response to rTMS used as add-on therapy.


CONCLUSIONS
Our preliminary results indicate that rTMS can improve mood in patients with medication-resistant depression, and can also potentially replace electroconvulsive therapy for certain types of medication-resistant depression. Future double-blind, placebo-controlled trials of rTMS are warranted.
Huang
Chih-Chia
CC
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Su
Tung-Ping
TP
Wei
I-Hua
IH
D000328:Adult; D000368:Aged; D003863:Depression / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000502:physiology; D011569:Psychiatric Status Rating Scales; D050781:Transcranial Magnetic Stimulation / Q000627:therapeutic use*