title: Rhabdomyoblastic pulmonary lesions in a patient with Wilms tumor: choristomas or metastases?
abstract: New lesions that occur while patients are receiving treatment for malignant tumors may represent not only difficulties in arriving at the correct diagnosis, but also impact on subsequent therapeutic options. We encountered a patient developing new pulmonary lesions during and after receiving treatment for Stage II Wilms tumor (WT). The presence of mature rhabdomyoblasts in multiple biopsy specimens allowed rational decisions to be made regarding subsequent therapy. This and other published experiences suggest that patients with WT may develop choristomas or have tumors, which undergo cytodifferentiation. Methodologies are now available allowing differentiation of these two processes.
authors.affiliation: Department of Pediatrics, School of Medicine, University of California, Davis Medical Center, Sacramento, 95817, USA. theodore.zwederling@ucdmc.ucdavis.edu
authors.forename: Ted
authors.initials: T
authors.lastname: Zwerdling
authors.forename: Jonathan
authors.initials: J
authors.lastname: Ducore
authors.forename: Douglas
authors.initials: D
authors.lastname: Taylor
authors.forename: Daniel C
authors.initials: DC
authors.lastname: West
authors.forename: Thomas
authors.initials: T
authors.lastname: Konia
mesh_terms: D001706:Biopsy; D002454:Cell Differentiation; D002828:Choristoma / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology* / Q000628:therapy; D008175:Lung Neoplasms / Q000473:pathology* / Q000556:secondary / Q000628:therapy; D032342:Muscle Cells / Q000473:pathology*; D009396:Wilms Tumor / Q000473:pathology* / Q000628:therapy