Cancer immunotherapy based on the killing of Salmonella typhimurium-infected tumour cells.
The use of bacteria for anticancer purposes was first attempted over 100 years ago. Recently, several strains of Salmonella have been shown to possess anticancer activity and, interestingly, Salmonella possesses a unique propensity to track to tumour tissue in vivo. This review presents the use of Salmonella for cancer immunotherapy, including the distinguishing characteristics of this organism and preclinical as well as clinical data.
Saltzman
Daniel A
DA
University of Minnesota Medical School, 195MMC 420 Delaware Street S.E., Minneapolis, Minnesota 55455, USA. saltz002@umn.edu
D000818:Animals; D045744:Cell Line, Tumor; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D009369:Neoplasms / Q000276:immunology* / Q000382:microbiology* / Q000628:therapy; D012486:Salmonella typhimurium / Q000276:immunology*