The evolving crosstalk between co-stimulatory and co-inhibitory receptors: HVEM-BTLA.
Receptors and their ligands on T cells and antigen-presenting cells are crucial for delivering inhibitory or stimulatory signals that enable immune cells to remain dormant or to respond effectively to various stimuli. The CD28-B7 and tumor necrosis factor receptor (TNFR)-TNF superfamilies contain many of these molecules and were thought to be distinct functioning modules. However, two studies have now provided a new perspective in this already complex area, showing not only a crosstalk between these superfamilies but potentially between co-stimulatory and co-inhibitory receptors.
Croft
Michael
M
Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA. mick@liai.org
D000818:Animals; D006801:Humans; D020239:Receptor Cross-Talk; D011971:Receptors, Immunologic / Q000145:classification / Q000276:immunology* / Q000378:metabolism*; D018124:Receptors, Tumor Necrosis Factor / Q000276:immunology / Q000378:metabolism; D053240:Receptors, Tumor Necrosis Factor, Member 14; D011991:Receptors, Virus / Q000276:immunology / Q000378:metabolism
C482586:BTLA protein, human; D011971:Receptors, Immunologic; D018124:Receptors, Tumor Necrosis Factor; D053240:Receptors, Tumor Necrosis Factor, Member 14; D011991:Receptors, Virus; C506028:TNFRSF14 protein, human