title: The effect of Irvingia gabonensis seeds on body weight and blood lipids of obese subjects in Cameroon.
abstract: Dietary fibres are frequently used for the treatment of obesity. The aim of this study was to evaluate the efficacy of Irvingia gabonensis seeds in the management of obesity. This was carried out as a double blind randomised study involving 40 subjects (mean age 42.4 years). Twenty-eight subjects received Irvingia gabonensis (IG) (1.05 g three time a day for one month) while 12 were on placebo (P) and the same schedule. During the one-month study period all subjects were on a normocaloric diet evaluated every week by a dietetic record book. At the end, the mean body weight of the IG group was decreased by 5.26 +/- 2.37% (p < 0.0001) and that of the placebo group by 1.32 +/- 0.41% (p < 0.02). The difference observed between the IG and the placebo groups was significant (p < 0.01). The obese patients under Irvingia gabonensis treatment also had a significant decrease of total cholesterol, LDL-cholesterol, triglycerides, and an increase of HDL-cholesterol. On the other hand, the placebo group did not manifest any changes in blood lipid components. Irvingia gabonensis seed may find application in weight lose.
authors.affiliation: Nutrition, HIV and Health Research Unit, Department of Biochemistry, P.O. Box 812, Faculty of Science, University of Yaounde I, Cameroon. jngondi@yahoo.com
authors.forename: Judith L
authors.initials: JL
authors.lastname: Ngondi
authors.forename: Julius E
authors.initials: JE
authors.lastname: Oben
authors.forename: Samuel R
authors.initials: SR
authors.lastname: Minka
mesh_terms: D000328:Adult; D019440:Anti-Obesity Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects*; D002482:Cellulose; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects; D018592:Cross-Over Studies; D004043:Dietary Fiber / Q000008:administration & dosage* / Q000627:therapeutic use*; D004311:Double-Blind Method; D002149:Energy Intake; D006801:Humans; D008055:Lipids / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D010919:Placebos; D012639:Seeds; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D019440:Anti-Obesity Agents; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004043:Dietary Fiber; D008055:Lipids; D010919:Placebos; D014280:Triglycerides; C051375:dikanut; D002482:Cellulose; D002784:Cholesterol