Ghrelin increases food intake in obese as well as lean subjects.
OBJECTIVE
To investigate whether effects on food intake are seen in obese subjects receiving exogenous administration of ghrelin.


METHODS
Randomised, double-blind, placebo-controlled study of intravenous ghrelin at doses 1 pmol/kg/min and 5 pmol/kg/min.


METHODS
In all, 12 healthy lean subjects (mean body mass index (BMI) 20.5+/-0.17 kg/m(2)) and 12 healthy overweight and obese subjects (mean BMI 31.9+/-1.02 kg/m(2)).


METHODS
Food intake, appetite and palatability of food, ghrelin and other obesity-related hormones, growth hormone.


RESULTS
Low-dose infusion of ghrelin increased ad libitum energy intake at a buffet meal in the obese group only (mean increase 36.6+/-9.4%, P<0.01.) High-dose ghrelin infusion increased energy intake in both groups (mean increase 20.1+/-10.6% in the lean and 70.1+/-15.5% in the obese, P<0.01 in both cases.) Ghrelin infusion increased palatability of food in the obese group.


CONCLUSIONS
Ghrelin increases food intake in obese as well as lean subjects. Obese people are sensitive to the appetite-stimulating effects of ghrelin and inhibition of circulating ghrelin may be a useful therapeutic target in the treatment of obesity.
Druce
M R
MR
Department of Metabolic Medicine, Imperial College, London, Hammersmith Hospital Campus, London, UK.
Wren
A M
AM
Park
A J
AJ
Milton
J E
JE
Patterson
M
M
Frost
G
G
Ghatei
M A
MA
Small
C
C
Bloom
S R
SR
D000328:Adult; D001066:Appetite / Q000187:drug effects / Q000502:physiology; D019167:Appetite Stimulants / Q000008:administration & dosage*; D015992:Body Mass Index; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004435:Eating / Q000187:drug effects*; D002149:Energy Intake / Q000502:physiology; D005260:Female; D054439:Ghrelin; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D007262:Infusions, Intravenous; D020738:Leptin / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood / Q000503:physiopathology*; D036361:Peptide Hormones / Q000008:administration & dosage* / Q000097:blood; D013649:Taste / Q000187:drug effects / Q000502:physiology
D019167:Appetite Stimulants; D054439:Ghrelin; D020738:Leptin; D036361:Peptide Hormones; D019382:Human Growth Hormone