title: White matter density in patients with schizophrenia, bipolar disorder and their unaffected relatives.
abstract: BACKGROUND
  This study sought to assess white matter density in patients and relatives with histories of bipolar disorder and/or schizophrenia.
  
  
  METHODS
  Subjects included those with schizophrenia from families affected by schizophrenia alone, those with bipolar disorder from families affected by bipolar disorder alone and those with bipolar disorder from families affected by both bipolar disorder and schizophrenia. Unaffected relatives of the three patient groups were also recruited. Subjects underwent an MRI brain scan which was analyzed using a white-matter optimized technique.
  
  
  RESULTS
  Subjects with schizophrenia and bipolar disorder showed reduced white matter density in the anterior limb of the internal capsule which was not found in unaffected relatives. Reductions were found in frontal subgyral white matter density in affected subjects with a family history of schizophrenia only.
  
  
  CONCLUSIONS
  Abnormal anterior internal capsule white matter may provide a structural substrate for both disorders.
authors.affiliation: Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF, Scotland, UK. andrew.mcintosh@ed.ac.uk
authors.forename: Andrew M
authors.initials: AM
authors.lastname: McIntosh
authors.forename: Dominic E
authors.initials: DE
authors.lastname: Job
authors.forename: T William J
authors.initials: TW
authors.lastname: Moorhead
authors.forename: Lesley K
authors.initials: LK
authors.lastname: Harrison
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Lawrie
authors.forename: Eve C
authors.initials: EC
authors.lastname: Johnstone
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D005190:Family; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000473:pathology*