Expression of p53 protein and primary tumour volume in patients with nasopharyngeal carcinoma.
OBJECTIVE
To investigate the relationship of p53 protein expression and primary tumour volume in patients with nasopharyngeal carcinoma.


METHODS
Retrospective study.


METHODS
Tertiary care centre.


METHODS
Forty-two newly diagnosed patients participated in the study.


METHODS
The relationship between p53 status, TNM stage, and computed tomography-derived primary tumour volume.


RESULTS
In patients with high p53 stains, the tumour volume was larger (p = .03). p53 was found to be independent of clinical stage (p = .84).


CONCLUSIONS
There is a positive correlation between primary tumour volume and p53 status.
Chen
Mu-Kuan
MK
Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, 135 Nanhsiau Street, Changhua 500, Taiwan.
Lee
Hong-Shen
HS
Chang
Julia H
JH
Chang
Cheng-Chuan
CC
D000293:Adolescent; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000235:genetics / Q000473:pathology*; D004396:Coloring Agents; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000235:genetics / Q000473:pathology*; D009367:Neoplasm Staging; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods; D016159:Tumor Suppressor Protein p53 / Q000032:analysis* / Q000235:genetics
D004396:Coloring Agents; D016159:Tumor Suppressor Protein p53