title: [Glutathione metabolism in rat cardiac tissues in acute doxorubicin-induced intoxication].
abstract: Experimental data are presented on the influence of acute doxorubicin intoxication with 7.47 and 2.34 mg/kg body mass on glutathione metabolism in cardiac tissues of albino non-inbred rats. Doxorubicin toxic effect resulted in such marked changes as decreased concentration of reduced glutathione and abnormal levels of glutathione reductase, glucoso-6-phoshate dehydrogenase, glutathione peroxidase and glutathione-S-transferase. Possible causes of such biochemical changes as well as their role in causation of doxorubicin cytotoxic effect are discussed. New methods of prophylaxis and lab diagnosis of doxorubicin-induced cardiomyopathy are suggested.
authors.forename: S I
authors.initials: SI
authors.lastname: Glushkov
authors.forename: S A
authors.initials: SA
authors.lastname: Kutsenko
authors.forename: T M
authors.initials: TM
authors.lastname: Novikova
authors.forename: V V
authors.initials: VV
authors.lastname: Aksenov
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000506:poisoning*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D051381:Rats
chemical_list: D004317:Doxorubicin; D005954:Glucosephosphate Dehydrogenase; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D005978:Glutathione