title: [The effect of esmolol on hemodynamic of the myocardial bridging-mural mural coronary artery].
abstract: OBJECTIVE
  To assess the effect of beta blocker on blood flow velocity and reserve on the intramural coronary artery of patients with myocardial bridging.
  
  
  METHODS
  In 8 patients with myocardial bridge, intracoronary Doppler was performed before and after esmolol was given intravenously. The basic average peak velocity (bAPV), hyperaemic average peak velocity (hAPV) of blood flow, and coronary flow reserve (CFR) proximal and distal to the mural myocardial bridging was measured and compared.
  
  
  RESULTS
  After esmolol injection, the mural coronary diameter systolic reduction decreased from (58.0 +/- 14.7)% to (26.0 +/- 9.8)% (P < 0.01); the bAPV proximal and distal to myocardial bridging separately decreased from (19.4 +/- 4.9) cm/s and (18.4 +/- 3.6) cm/s to (4.7 +/- 3.9) cm/s (P < 0.01) and (15.1 +/- 1.5) cm/s (P < 0.05). Under hyperemization, esmolol changed the hAPV of proximal and distal to myocardial bridging separately from (54.1 +/- 14.9) cm/s and (44.7 +/- 9.4) cm/s to (49.7 +/- 16.4) cm/s and (48.9 +/- 10.1) cm/s (all P > 0.05); thus, the value of CFR both proximal and distal to myocardial bridge increased separately from 2.8 +/- 0.3 and 2.5 +/- 0.5 to 3.4 +/- 0.5 and 3.2 +/- 0.6 (all P < 0.01).
  
  
  CONCLUSIONS
  Esmolol can decreased the compression of the intramural coronary artery and increased the CFR to normal level of it.
authors.affiliation: The First People's Hospital, Zhenjiang 212002, China.
authors.forename: Guo-Hui
authors.initials: GH
authors.lastname: Zhang
authors.forename: Jun-Bo
authors.initials: JB
authors.lastname: Ge
authors.forename: Ju-Ying
authors.initials: JY
authors.lastname: Qian
authors.forename: Bing
authors.initials: B
authors.lastname: Fan
authors.forename: Qi-Bing
authors.initials: QB
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Lu
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Qi
authors.initials: Q
authors.lastname: Feng
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D003326:Coronary Circulation / Q000187:drug effects / Q000502:physiology*; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D054084:Myocardial Bridging / Q000188:drug therapy / Q000503:physiopathology* / Q000648:ultrastructure; D011412:Propanolamines / Q000494:pharmacology* / Q000627:therapeutic use; D018084:Ultrasonography, Interventional
chemical_list: D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; C036604:esmolol