title: A pilot study on the use of a perfluorohexyloctane/silicone oil solution as a heavier than water internal tamponade agent.
abstract: OBJECTIVE
  To report a prospective two centred non-comparative interventional pilot study of a solution of perfluorohexyloctane and silicone oil (Densiron-68) as a heavier than water internal tamponade.
  
  
  METHODS
  42 consecutive patients were recruited. The indications include proliferative vitreoretinopathy, retinal detachments arising from inferior retinal breaks, and inability to posture.
  
  
  RESULTS
  The success rate with one operation using Densiron was 81% and with further surgery 93%. At the end of the study all tamponade agents were removed in 90% of patients. Visual acuity improved from mean logMAR of 1.41 (SD 0.64) to 0.94 (SD 0.57), p = 0.001. There was little evidence of dispersion and excessive inflammation.
  
  
  CONCLUSIONS
  This new tamponade agent is being compared to conventional silicone oil in a prospective international randomised trial.
authors.affiliation: St Paul's Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK. shdwong@liv.ac.uk
authors.forename: D
authors.initials: D
authors.lastname: Wong
authors.forename: J C
authors.initials: JC
authors.lastname: Van Meurs
authors.forename: T
authors.initials: T
authors.lastname: Stappler
authors.forename: C
authors.initials: C
authors.lastname: Groenewald
authors.forename: I A
authors.initials: IA
authors.lastname: Pearce
authors.forename: J N
authors.initials: JN
authors.lastname: McGalliard
authors.forename: E
authors.initials: E
authors.lastname: Manousakis
authors.forename: E N
authors.initials: EN
authors.lastname: Herbert
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004338:Drug Combinations; D005260:Female; D005466:Fluorocarbons / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000209:etiology; D010865:Pilot Projects; D011182:Postoperative Care / Q000379:methods; D011183:Postoperative Complications; D011187:Posture; D011446:Prospective Studies; D012008:Recurrence; D012163:Retinal Detachment / Q000503:physiopathology / Q000601:surgery*; D012827:Silicone Oils / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D013046:Specific Gravity; D016896:Treatment Outcome; D014792:Visual Acuity; D014821:Vitrectomy / Q000379:methods; D018630:Vitreoretinopathy, Proliferative / Q000503:physiopathology / Q000601:surgery
chemical_list: D004338:Drug Combinations; D005466:Fluorocarbons; D012827:Silicone Oils; C118616:perfluorohexyl-octan