Adipocyte signaling and lipid homeostasis: sequelae of insulin-resistant adipose tissue.
For many years adipose tissue was viewed as the site where excess energy was stored, in the form of triglycerides (TGs), and where that energy, when needed elsewhere in the body, was released in the form of fatty acids (FAs). Recently, it has become clear that when the regulation of the storage and release of energy by adipose tissue is impaired, plasma FA levels become elevated and excessive metabolism of FA, including storage of TGs, occurs in nonadipose tissues. Most recently, work by several laboratories has made it clear that in addition to FA, adipose tissue communicates with the rest of the body by synthesizing and releasing a host of secreted molecules, collectively designated as adipokines. Several recent reviews have described how these molecules, along with FA, significantly effect total body glucose metabolism and insulin sensitivity. Relatively little attention has been paid to the effects of adipokines on lipid metabolism. In this review, we will describe, in detail, the effects of molecules secreted by adipose tissue, including FA, leptin, adiponectin, resistin, TNF-alpha, IL-6, and apolipoproteins, on lipid homeostasis in several nonadipose tissues, including liver, skeletal muscle, and pancreatic beta cells.
Yu
Yi-Hao
YH
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. hng1@columbia.edu
Ginsberg
Henry N
HN
D017667:Adipocytes / Q000378:metabolism*; D052242:Adiponectin; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D001053:Apolipoproteins / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D006706:Homeostasis; D006729:Hormones, Ectopic / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D000078790:Insulin Secretion; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D015850:Interleukin-6 / Q000494:pharmacology; D007515:Islets of Langerhans / Q000378:metabolism; D020738:Leptin / Q000502:physiology; D050356:Lipid Metabolism; D008079:Lipoproteins, VLDL / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D052243:Resistin; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
D052242:Adiponectin; D001053:Apolipoproteins; D005227:Fatty Acids; D006729:Hormones, Ectopic; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D015850:Interleukin-6; D020738:Leptin; D008079:Lipoproteins, VLDL; C499624:RETN protein, human; D052243:Resistin; D014409:Tumor Necrosis Factor-alpha