Cytotoxic steroidal saponins from the rhizomes of Asparagus oligoclonos.
Two new steroidal saponins, aspaoligonins A (2) and B (3), were isolated from the methanolic extract of the rhizomes of Asparagus oligoclonos together with a known spirostanol saponin, asparanin A (1). Aspaoligonins A and B were characterized as (25S*)-5beta-spirostan-3beta,17alpha-diol 3-O-beta-D-glucopyranosyl (1-->2)-beta-D-glucopyranoside and (25S*)-5beta-spirostan-3beta,17alpha-diol 3-O-alpha-L-rhamnopyanosyl (1-->4)-[beta-D-xylopyranosyl-(1-->2)]-beta-D-glucopyranoside, respectively, by spectrometric analyses including HRFABMS and 2D NMR. Compounds 1-3 were cytotoxic against five human tumor cell lines with IC50 values of 2.05-2.84 microg/mL.
Kim
Geum-Soog
GS
Ginseng & Medicinal Crops Division, National Institute of Crop Science (NICS), Rural Development Administration (RDA), Suwon 441-857, Korea.
Kim
Hyun-Tae
HT
Seong
Jae-Duck
JD
Oh
Sei-Ryang
SR
Lee
Chong-Ock
CO
Bang
Jin-Ki
JK
Seong
Nak-Sul
NS
Song
Kyung-Sik
KS
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D027761:Asparagus Plant / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D007723:Korea; D010946:Plants, Medicinal / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013150:Spirostans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D013150:Spirostans; C501797:aspaoligonin A; C501798:aspaoligonin B