Cell cycle and cell-fate determination in Drosophila neural cell lineages.
"Normal" development requires a finely tuned equilibrium between cell differentiation and cell proliferation. Important issues in development include whether the cell cycle controls the cell-fate determination and whether cell identity in turn regulates cell-cycle progression. Although, these issues are of general biological relevance, stereotyped Drosophila neural lineages are particularly suited to address these questions and have provided insights into the links between cell-cycle progression and cell-fate specification.
Fichelson
Pierre
P
Institut Jacques Monod, CNRS, University Paris 6 and 7, 2 Place Jussieu, 75005 Paris, France.
Audibert
Agnès
A
Simon
Françoise
F
Gho
Michel
M
D000818:Animals; D002453:Cell Cycle; D019070:Cell Lineage; D049109:Cell Proliferation; D048749:Cytokinesis; D004330:Drosophila / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D008954:Models, Biological; D009420:Nervous System / Q000196:embryology*; D009474:Neurons / Q000378:metabolism*; D016196:S Phase