[DNA damage induced by products of lipid peroxidation].
The adduction of the aldehydic end-products of lipid peroxidation to DNA induces bulky adducts, leading to genome instability. The bulky-DNA adducts are miscoding and thus play a fundamental role in mutagenesis and cancerogenesis. Special attention is given to the etheno- and propanoadducts, recognized as DNA modifiers. Such DNA lesions are repaired by different DNA repair mechanisms, mainly base excision repair (BER) and nucleotide excision repair (NER), as well as nucleotide incision repair (NIR) and transcription-coupled repair (TCR).
Przybyszewski
Waldemar M
WM
Zakład Radiobiologii Doświadczalnej i Klinicznej, Centrum Onkologii, Instytut im.M.Skłodowskiej-Curie, Oddział w Gliwicach, 44-101 Gliwice. wmp@io.gliwice.pl
Kasperczyk
Janusz
J
Stokłosa
Katarzyna
K
Bkhiyan
Arayik
A
D000818:Animals; D018736:DNA Adducts / Q000502:physiology; D004249:DNA Damage / Q000502:physiology*; D004260:DNA Repair; D005609:Free Radicals / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D016296:Mutagenesis / Q000235:genetics; D017382:Reactive Oxygen Species / Q000378:metabolism; D014158:Transcription, Genetic
D018736:DNA Adducts; D005609:Free Radicals; D017382:Reactive Oxygen Species