[Thyroid functional activity in an experiment upon exposure to manganeferous dust].
The purpose of the study was to examine the effect of polymetallic manganeferous dust on thyroid function in an experiment. Biochemical and cytological studies were used. Seventy-day exposure caused decreased thyroid hormonal levels and thyroid cellular composition changes, which suggest that the dust in question has a cytotoxic effect. A prolonged (3-month) exposure provided evidence that suggests the tension of adaptive mechanisms in the thyroid system under the influence of a toxic factor. Nitric oxide was found to take an active part in the formation of adaptive mechanisms in thyroid tissue.
Namazbaeva
Z I
ZI
Knashina
G M
GM
Rakishev
E K
EK
Mukasheva
M A
MA
Bud'kova
L A
LA
Baĭmukhanov
R M
RM
D000220:Adaptation, Biological / Q000187:drug effects; D000818:Animals; D004391:Dust; D005500:Follow-Up Studies; D008297:Male; D017895:Manganese Compounds / Q000009:adverse effects* / Q000493:pharmacokinetics; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D013963:Thyroid Hormones / Q000378:metabolism
D004391:Dust; D017895:Manganese Compounds; D013963:Thyroid Hormones; D009569:Nitric Oxide