title: Antiobesity evaluation of histamine H3 receptor (H3R) antagonist analogs of A-331440 with improved safety and efficacy.
authors.affiliation: Department R4MN, AP9A-3, Abbott Laboratories, Global Pharmaceutical Research and Development, 100 Abbott Park Road, Abbott Park, IL 60064-6125, USA. Art.A.Hancock@Abbott.com
authors.forename: A A
authors.initials: AA
authors.lastname: Hancock
authors.forename: M S
authors.initials: MS
authors.lastname: Diehl
authors.forename: T A
authors.initials: TA
authors.lastname: Fey
authors.forename: E N
authors.initials: EN
authors.lastname: Bush
authors.forename: R
authors.initials: R
authors.lastname: Faghih
authors.forename: T R
authors.initials: TR
authors.lastname: Miller
authors.forename: K M
authors.initials: KM
authors.lastname: Krueger
authors.forename: J K
authors.initials: JK
authors.lastname: Pratt
authors.forename: M D
authors.initials: MD
authors.lastname: Cowart
authors.forename: R W
authors.initials: RW
authors.lastname: Dickinson
authors.forename: R
authors.initials: R
authors.lastname: Shapiro
authors.forename: V E
authors.initials: VE
authors.lastname: Knourek-Segel
authors.forename: B A
authors.initials: BA
authors.lastname: Droz
authors.forename: C A
authors.initials: CA
authors.lastname: McDowell
authors.forename: G
authors.initials: G
authors.lastname: Krishna
authors.forename: M E
authors.initials: ME
authors.lastname: Brune
authors.forename: T A
authors.initials: TA
authors.lastname: Esbenshade
authors.forename: P B
authors.initials: PB
authors.lastname: Jacobson
mesh_terms: D000818:Animals; D001713:Biphenyl Compounds / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology; D017442:Histamine Agonists / Q000737:chemistry / Q000494:pharmacology; D006633:Histamine Antagonists / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D015394:Molecular Structure; D009570:Nitriles / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D009765:Obesity / Q000139:chemically induced / Q000378:metabolism* / Q000517:prevention & control*; D011759:Pyrrolidines / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D018100:Receptors, Histamine H3 / Q000378:metabolism*
chemical_list: C493218:4'-(3-(3(R)-(dimethylamino)-pyrrolidin-1-yl)-propoxy)-biphenyl-4-carbonitrile; D001713:Biphenyl Compounds; D004041:Dietary Fats; D017442:Histamine Agonists; D006633:Histamine Antagonists; D009570:Nitriles; D011759:Pyrrolidines; D018100:Receptors, Histamine H3