title: Novel phomactin analogues as PAF receptor ligands.
abstract: A range of natural and unnatural phomactins, recently synthesised in our laboratory, were found to exhibit PAF antagonism with pIC(50) values in the range 5.6-6.2. The variation in structural and stereochemical features between the phomactins was found to have only a modest effect on the inhibition of binding of PAF to its human platelet receptors.
authors.affiliation: School of Chemistry, The University of Nottingham, University Park, Nottingham NG7 2RD, UK.
authors.forename: William P D
authors.initials: WP
authors.lastname: Goldring
authors.forename: Stephen P H
authors.initials: SP
authors.lastname: Alexander
authors.forename: David A
authors.initials: DA
authors.lastname: Kendall
authors.forename: Gerald
authors.initials: G
authors.lastname: Pattenden
mesh_terms: D001792:Blood Platelets; D002462:Cell Membrane / Q000737:chemistry; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D008024:Ligands; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D010980:Platelet Membrane Glycoproteins / Q000737:chemistry* / Q000302:isolation & purification; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry* / Q000302:isolation & purification; D013329:Structure-Activity Relationship
chemical_list: D006576:Heterocyclic Compounds, 4 or More Rings; D008024:Ligands; D010972:Platelet Activating Factor; D010980:Platelet Membrane Glycoproteins; D043562:Receptors, G-Protein-Coupled; C039351:platelet activating factor receptor; C413206:phomactin A