Molecular pathology and clinical characteristics of oligodendroglial neoplasms.
To evaluate the role of molecular genetics in the routine clinic, we investigated allelic imbalance at 1p36, 19q13, 17p13, 10p12-15, and 10q22-26 and p53 mutation in 100 oligodendroglial neoplasms diagnosed at a single treatment center between 2000 and 2003. The -1p/-19q genotype, seen in 64, 34, 77, and 30% of OII, OAII, OIII, and OAIII respectively, was inversely related to p53 mutation and 17p13 loss. Genotype was unrelated to tumor location and could not distinguish high-grade tumors that presented de novo from those that progressed from a previous lower grade malignancy. Presentation with seizures was more common in cases with the -1p/-19q genotype, and these remained stable for longer before treatment. In longitudinal samples, 74% retained their initial histological differentiation, whereas 29% showed new genetic alterations, the -1p/-19q genotype being acquired in three cases. Loss of 1p36 and 19q13, 17p13, chromosome 10, and p53 mutation were significantly associated with survival from presentation in Kaplan-Meier analysis (p < 0.01), and loss of 1p36 and 19q13 and loss of 17p13 retained significance in multivariate analysis. In this recently diagnosed unselected series, clinical differences in tumors with and without the -1p/-19q genotype support a genetic approach to aid diagnosis and prognostication for oligodendroglial neoplasms.
Walker
Carol
C
JK Douglas Laboratories, Bebington, Wirral, United Kingdom. carol.walker@ccrt.nhs.uk
du Plessis
Daniel G
DG
Joyce
Kathy A
KA
Fildes
Diane
D
Gee
Abigail
A
Haylock
Brian
B
Husband
David
D
Smith
Trevor
T
Broome
John
J
Warnke
Peter C
PC
D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology*; D002878:Chromosomes, Human, Pair 1; D002879:Chromosomes, Human, Pair 10; D002886:Chromosomes, Human, Pair 17; D002888:Chromosomes, Human, Pair 19; D005260:Female; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics / Q000401:mortality / Q000473:pathology; D009837:Oligodendroglioma / Q000235:genetics* / Q000401:mortality / Q000473:pathology*; D010641:Phenotype; D011379:Prognosis; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
D016159:Tumor Suppressor Protein p53