[Sensitivity to penicillin G of isolates of pneumococci meningitis and therapeutic implication in CHU of Treichville, Abidjan].
To determine the frequency of pneumococci meningitis with reduced sensitivity to penicillin G isolated from cerebrospinal fluid, 539 strains were studied between 1996 to 2000. All strains were analysed with oxacilline containing 5 mcg / standard antibiogram for determination of minimal inhibitory concentration (MIC) for penicillin G by E-test. Our results do not show any significant variation from 1996 to 2000. Generally as regard the penicillin G sensitivity we observed that strains were classified as: sensitive strains (CMI < or = 0.06 mg/l): 22.5%, less sensitive strains (0.6 mg/l < CMI < or = 2 mg/l): 58.2%, resistance (CMI > 2 mg/l): 19.2%. The pneumococci rate with reduced sensitivity observed in our study is high and should be taken into consideration in the therapeutic choices.
Edoh
V
V
Laboratoire de bactériologie-virologie, CHU de Treichville, BP V03 Abidjan, Côte d'lvoire.
Kakou
A R
AR
Tia
H
H
Oulai
S M
SM
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D007560:Cote d'Ivoire; D006801:Humans; D008586:Meningitis, Pneumococcal / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D010400:Penicillin G / Q000494:pharmacology*; D011446:Prospective Studies; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D010400:Penicillin G