Reactive oxygen species: biological stimuli of neuroblastoma cell response.
Reactive oxygen species play a critical role in differentiation, proliferation and apoptosis acting as 'second messengers' able to regulate sulphydryl groups in signaling molecules as protein kinase C, a family of isoenzymes involved in many cellular responses and implicated in cell transformation. Neuroblastoma is characterised by the production of oxygen intermediates and L-buthionine-S,R-sulfoximine, a glutathione-depleting agent that has been tested in the clinics, exploits this biological peculiarity to induce cell death. The latter process is mediated by the oxidative activation of PKC delta which might be involved also in the production of reactive oxygen species, thus amplifying the apoptotic cascade.
Marengo
Barbara
B
Department of Experimental Medicine, Section of General Pathology, University of Genova, Via L.B. Alberti, 2, 16132, Genoa, Italy.
Raffaghello
Lizzia
L
Pistoia
Vito
V
Cottalasso
Damiano
D
Pronzato
Maria Adelaide
MA
Marinari
Umberto Maria
UM
Domenicotti
Cinzia
C
D017209:Apoptosis; D006801:Humans; D009447:Neuroblastoma / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D011493:Protein Kinase C / Q000378:metabolism; D017382:Reactive Oxygen Species; D015398:Signal Transduction
D017382:Reactive Oxygen Species; D011493:Protein Kinase C