Redox status of dogs with non-hodgkin lymphomas. An ESR study.
Free radical and antioxidant parameters in healthy dogs (n=10) and dogs with non-Hodgkin lymphomas (n=11) were measured in blood and lymph node tissue samples before chemotherapy. Enzymatic and other biochemical measurements were performed. We found that (i) free radical concentrations based on ESR spectra of tissues correlated with higher proliferative character; (ii) lymphoma cases showed an impaired antioxidant status; (iii) tumors with low oxidative burst capacity and higher reduced/oxidized glutathione ratio responded better to chemotherapy; and (iv) affected blood and lymph nodes were under strong oxidative stress.
Vajdovich
Péter
P
Department of Internal Medicine and Clinics, Faculty of Veterinary Sciences, Szent István University, Budapest, Hungary. pvajdo@univet.hu
Kriska
Tamás
T
Mézes
Miklós
M
Szabó
Piroska Ribiczey
PR
Balogh
Nándor
N
Bánfi
András
A
Arany-Tóth
Attila
A
Gaál
Tibor
T
Jakus
Judit
J
D000818:Animals; D000975:Antioxidants / Q000032:analysis*; D049109:Cell Proliferation; D004283:Dog Diseases / Q000503:physiopathology*; D004285:Dogs; D005260:Female; D005609:Free Radicals / Q000097:blood*; D008228:Lymphoma, Non-Hodgkin / Q000503:physiopathology* / Q000662:veterinary*; D008297:Male; D018384:Oxidative Stress; D013057:Spectrum Analysis
D000975:Antioxidants; D005609:Free Radicals