title: Macrophage migration inhibitory factor reduces the growth of virulent Mycobacterium tuberculosis in human macrophages.
abstract: Macrophage migration inhibitory factor (MIF) is a key mediator of the innate immune system and plays a crucial role in the host response to bacterial infections. Its role in immunity to intracellular pathogens has not been well studied. Here, we show that MIF released by infected human macrophages inhibits the growth of virulent Mycobacterium tuberculosis.
authors.affiliation: Medical Critical Care Division, University Hospital, CH-1011 Lausanne, Switzerland. mauro.oddo@chuv.hospvd.ch
authors.forename: Mauro
authors.initials: M
authors.lastname: Oddo
authors.forename: Thierry
authors.initials: T
authors.lastname: Calandra
authors.forename: Richard
authors.initials: R
authors.lastname: Bucala
authors.forename: Pascal R A
authors.initials: PR
authors.lastname: Meylan
mesh_terms: D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors / Q000502:physiology*; D008264:Macrophages / Q000276:immunology* / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000254:growth & development / Q000276:immunology*; D014774:Virulence
chemical_list: D008263:Macrophage Migration-Inhibitory Factors