Structural biology of G protein-coupled receptors.
More than 60% of the current drugs are based on G protein-coupled receptors. Paradoxically, high-resolution structures are not available to facilitate rational drug design. Difficulties in expression, purification, and crystallization of these transmembrane receptors are the reasons for the low success rate. Recent individual and network-based technology development has significantly improved our knowledge of structural biology and might soon bring a major breakthrough in this area.
Lundstrom
Kenneth
K
BioXtal, Chemin des Croisettes 22, CH-1066 Epalinges, Switzerland. klunstrom@mepnet.org
D000818:Animals; D003195:Computer Communication Networks; D003460:Crystallization; D015195:Drug Design; D006801:Humans; D008958:Models, Molecular; D016297:Mutagenesis, Site-Directed; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry* / Q000187:drug effects / Q000502:physiology*; D013329:Structure-Activity Relationship
D043562:Receptors, G-Protein-Coupled