Prolonged activation of the baroreflex: a viable approach for the treatment of hypertension?
In most patients with hypertension, arterial pressure is above the target level for control, even in those individuals taking multiple antihypertensive drugs. In this article, we review the history and current status of a nonpharmacologic approach for the treatment of hypertension--chronic electrical activation of the afferent limb of the carotid baroreflex. Recent studies in normotensive and hypertensive dogs have clearly demonstrated impressive and sustained reductions in arterial pressure and sympathetic activity during prolonged baroreflex activation. Clinical trials are now underway in Europe, and clinical investigation in the United States will begin this year to evaluate the efficacy of this therapy in patients with resistant hypertension.
Lohmeier
Thomas E
TE
Department of Physiology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505, USA. tlohmeier@physiology.umsmed.edu
Barrett
Austin M
AM
Irwin
Eric D
ED
D000818:Animals; D017704:Baroreflex / Q000502:physiology*; D002346:Carotid Sinus / Q000294:innervation; D004285:Dogs; D004558:Electric Stimulation; D006801:Humans; D006973:Hypertension / Q000503:physiopathology* / Q000628:therapy*; D013564:Sympathetic Nervous System / Q000502:physiology