[Intensive therapy for multiple organ dysfunction in neonatal infants after cardiosurgical interventions].
This study was undertaken to evaluate the efficiency of complex intensive therapy for multiple organ dysfunction syndrome (MODS) after cardiosurgical interventions at the resuscitative and intensive care unit of the A. N. Bakulev Research Center of Cardiovascular Surgery, Russian Academy of Medical Sciences. In 2003-2004, MODS developed in 70 (37%) of the neonatal infants operated on the heart and vessels. The babies' age ranged from 6 hours of life to 1 month (8.3 +/- 2.1 days of life, their body weight was from 1.7 to 4.1 kg (3.0 +/- 0.49 kg). All the patients were found to have significant renal and respiratory failures. There were more than 4 (4.1 +/- 0.5) failing vital viscera. The use of phosphodiesterase (III) inhibitors in therapy for acute left ventricular insufficiency significantly improved the performance of the left heart whereas nitric oxide inhalation significantly lowered pulmonary pressure in babies with acute right ventricular insufficiency and improved oxygenation in patients with MODS. The efficiency of nitric oxide inhalation in MODS significantly increased when it was used in combination with endotracheal administration of a surfactant and high-frequency oscillatory ventilation. Peritoneal dialysis effectively replaced renal function when acute renal failure (ARF) developed. Nevertheless, the development of ARF in the pattern of MODS is a marker of high mortality (89% in ARF versus 46% in MODS without ARF).
Bokeriia
L A
LA
Lobacheva
G V
GV
Iarustovskiĭ
M B
MB
Khar'kin
A V
AV
Aksenov
V A
VA
Grigor'iants
R G
RG
Mannerova
A F
AF
Kvasnikov
B B
BB
Frolova
E I
EI
D058186:Acute Kidney Injury / Q000628:therapy; D018376:Cardiovascular Abnormalities / Q000601:surgery*; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D007231:Infant, Newborn; D015931:Intensive Care, Neonatal; D008297:Male; D009102:Multiple Organ Failure / Q000401:mortality / Q000628:therapy*; D010530:Peritoneal Dialysis; D011184:Postoperative Period; D013577:Syndrome