Synthesis of thiazolyl and thieno cholestane derivatives: a novel class of potent antiinflammatory steroids.
The reactivity of 5alpha-cholestan-3-one (1) towards the formation of thiazolyl derivatives of potential antiinflammatory activity was studied. Also starting with the aminothieno[2',3': 2,3]cholestane derivative 8 several thiazolylthieno[2',3':2,3]cholestane derivatives were synthesized. The structures of the new compounds were established based on the analytical and spectral data and the in vivo antiinflammatory activities of some of these compounds were investigated.
Elmegeed
G A
GA
Hormone Department, National Research Centre, Dokki, Giza, Egypt. gamalae@hotmail.com
Wardakhan
W W
WW
Baiuomy
A R
AR
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002351:Carrageenan; D002776:Cholestanes / Q000138:chemical synthesis* / Q000494:pharmacology*; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D000893:Anti-Inflammatory Agents; D002776:Cholestanes; D006571:Heterocyclic Compounds; D007202:Indicators and Reagents; D002351:Carrageenan