Functional genomics of cardiac ion channel genes.
Ion channels are an ensemble of specialized membrane proteins that act in concert to create and modulate the electrical activity of many excitable cells, including cardiac myocytes. Following completion of the sequencing of various genomes, including that of the human, the complete repertoire of ion channel genes has been elucidated for different species. How transcripts issued from this gene collection are expressed and modulated in relation to variable physiological and pathological situations is the subject of functional or physiological genomics. Specialized microarrays (IonChips) comprising probes for the ensemble of ion channel and regulatory genes were developed as an alternative to whole-genome DNA chips. Physiological genomics of cardiac ion channel genes is a growing field that, in combination with genetics, should markedly increase our comprehension of the molecular mechanisms leading to arrhythmias.
Demolombe
Sophie
S
L'institut du thorax, INSERM U533, Faculté de Médecine, 1 rue Gaston Veil, 44035 Nantes cedex, France.
Marionneau
Céline
C
Le Bouter
Sabrina
S
Charpentier
Flavien
F
Escande
Denis
D
D000638:Amiodarone / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D005544:Forecasting; D020869:Gene Expression Profiling; D023281:Genomics / Q000379:methods*; D006801:Humans; D007473:Ion Channels / Q000235:genetics* / Q000378:metabolism*; D008958:Models, Molecular; D009206:Myocardium / Q000378:metabolism*; D020411:Oligonucleotide Array Sequence Analysis; D013963:Thyroid Hormones / Q000494:pharmacology
D000889:Anti-Arrhythmia Agents; D007473:Ion Channels; D013963:Thyroid Hormones; D000638:Amiodarone