title: Cassane- and norcassane-type diterpenes from Caesalpinia crista of Indonesia and their antimalarial activity against the growth of Plasmodium falciparum.
abstract: The CH2Cl2 extract of the seed kernels of Caesalpinia crista, which exhibited promising antimalarial activity against Plasmodium berghei-infected mice in vivo, was examined and resulted in the isolation of seven new furanocassane-type diterpenes [caesalpinins C-G (1-5) and norcaesalpinins D and E (6, 7)] together with norcaesalpinins A-C (8-10) and 11 known compounds (norcaesalpinins A-C, 2-acetoxy-3-deacetoxycaesaldekarin e, caesalmin B, caesaldekarin e, caesalpin F, 14(17)-dehydrocaesalpin F, 2-acetoxycaesaldekarin e, 7-acetoxybonducellpin C, and caesalmin G). Their structures were determined on the basis of spectroscopic analysis. The isolated diterpenes showed significant dose-dependent inhibitory effects on Plasmodium falciparum FCR-3/A2 growth in vitro. Their IC50 values ranged from 90 nM to 6.5 microM, and norcaesalpinin E (7) showed the most potent inhibitory activity (IC50, 90 nM).
authors.affiliation: Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Thein Zaw
authors.initials: TZ
authors.lastname: Linn
authors.forename: Suresh
authors.initials: S
authors.lastname: Awale
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Tezuka
authors.forename: Arjun H
authors.initials: AH
authors.lastname: Banskota
authors.forename: Surya K
authors.initials: SK
authors.lastname: Kalauni
authors.forename: Faisal
authors.initials: F
authors.lastname: Attamimi
authors.forename: Jun-Ya
authors.initials: JY
authors.lastname: Ueda
authors.forename: Puji Budi Setia
authors.initials: PB
authors.lastname: Asih
authors.forename: Din
authors.initials: D
authors.lastname: Syafruddin
authors.forename: Ken
authors.initials: K
authors.lastname: Tanaka
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Kadota
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029911:Caesalpinia / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007214:Indonesia; D020128:Inhibitory Concentration 50; D051379:Mice; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D010962:Plasmodium berghei / Q000187:drug effects; D010963:Plasmodium falciparum / Q000187:drug effects; D012639:Seeds / Q000737:chemistry
chemical_list: D000962:Antimalarials; D004224:Diterpenes