title: Structure and assembly of group I introns.
abstract: Self-splicing group I introns have served as a model for RNA catalysis and folding for over two decades. New three-dimensional structures now bring the details into view. Revelations include an unanticipated turn in the RNA backbone around the guanosine-binding pocket. Two metal ions in the active site coordinate the substrate and phosphates from all three helical domains.
authors.affiliation: TC Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218-2685, USA. swoodson@jhu.edu
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Woodson
mesh_terms: D001483:Base Sequence; D002384:Catalysis; D004789:Enzyme Activation; D046911:Macromolecular Substances / Q000032:analysis / Q000737:chemistry / Q000145:classification; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D017510:Protein Folding; D012326:RNA Splicing; D016337:RNA, Catalytic / Q000032:analysis / Q000737:chemistry* / Q000145:classification; D016415:Sequence Alignment; D017423:Sequence Analysis, RNA / Q000379:methods*; D013329:Structure-Activity Relationship
chemical_list: C116167:GIR1 ribozyme; D046911:Macromolecular Substances; D016337:RNA, Catalytic