Endoscopic therapies for gastroesophageal reflux disease.
Gastroesophageal reflux disease (GERD) is a chronic condition affect-ing over 7% of the US population. The primary objective of therapy is symptom relief, with secondary goals to heal esophagitis, prevent reflux-related complications, and maintain remission. There are several new endoscopic therapies (ETs) for treatment of GERD, generating considerable interest. An outpatient procedure, performed without an incision and general anesthesia, is attractive to patients and these therapies are being rapidly introduced, despite lack of long-term follow-up and randomized trials. In this article, the authors review endoscopic procedures, including technical aspects, mechanisms of action, safety, efficacy, and tolerability. Patient selection and relevant human studies are reviewed to clarify advantages and disadvantages of ET compared with conventional procedures.
de Hoyos
Alberto
A
Cardiothoracic Surgery, Northwestern Memorial Hospital, 215 East Huron 10-105, Chicago, IL 60611, USA.
Fernando
Hiran C
HC
D017115:Catheter Ablation / Q000379:methods; D004945:Esophagoscopy / Q000379:methods*; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000627:therapeutic use; D011145:Polyvinyls / Q000627:therapeutic use*; D019919:Prosthesis Implantation / Q000379:methods
D011145:Polyvinyls; C020320:ethylene-vinyl alcohol copolymer; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate