title: Tissue migration by parasitic helminths - an immunoevasive strategy?
abstract: Migration through host tissues has major costs for parasitic helminths in terms of energy expenditure, risks of attrition and the need to adapt to varying physicochemical environments. Nevertheless, such migratory phases seem to confer a specific survival advantage. One reason for this might be the avoidance of specific host immune-defence mechanisms designed to protect against threats at mucosal surfaces.
authors.affiliation: Department of Veterinary Microbiology and Parasitology, Faculty of Veterinary Medicine and Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland. grace.mulcahy@ucd.ie
authors.forename: Grace
authors.initials: G
authors.lastname: Mulcahy
authors.forename: Sandra
authors.initials: S
authors.lastname: O'Neill
authors.forename: June
authors.initials: J
authors.lastname: Fanning
authors.forename: Elaine
authors.initials: E
authors.lastname: McCarthy
authors.forename: Mary
authors.initials: M
authors.lastname: Sekiya
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D006373:Helminthiasis / Q000276:immunology* / Q000469:parasitology*; D006376:Helminths / Q000276:immunology / Q000502:physiology*; D006790:Host-Parasite Interactions; D006801:Humans; D007113:Immunity, Innate; D018928:Immunity, Mucosal; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology