DNA vaccines for biodefence.
The advantages associated with DNA vaccines include the speed with which they may be constructed and produced at large-scale, the ability to produce a broad spectrum of immune responses, and the ability for delivery using non-invasive means. In addition, DNA vaccines may be manipulated to express multiple antigens and may be tailored for the induction of appropriate immune responses. These advantages make DNA vaccination a promising approach for the development of vaccines for biodefence. In this review, the potential of DNA vaccines for biodefence is discussed.
Garmory
Helen S
HS
Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury, SP4 0JQ, UK. hsgarmory@dstl.gov.uk
Perkins
Stuart D
SD
Phillpotts
Robert J
RJ
Titball
Richard W
RW
D000818:Animals; D001424:Bacterial Infections / Q000276:immunology / Q000517:prevention & control*; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology; D001694:Biological Warfare; D004337:Drug Carriers; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008081:Liposomes; D013678:Technology, Pharmaceutical / Q000639:trends*; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology / Q000517:prevention & control*
D001428:Bacterial Vaccines; D004337:Drug Carriers; D008081:Liposomes; D019444:Vaccines, DNA; D014765:Viral Vaccines