title: Can cell systems biology rescue drug discovery?
abstract: The focus of innovation in current drug discovery is on new targets, yet compound efficacy and safety in biological models of disease - not target selection - are the criteria that determine which drug candidates enter the clinic. We consider a biology-driven approach to drug discovery that involves screening compounds by automated response profiling in disease models based on complex human-cell systems. Drug discovery through cell systems biology could significantly reduce the time and cost of new drug development.
authors.affiliation: Department of Pathology, Stanford University, Stanford, California 94305-5324, USA. ebutcher@stanford.edu
authors.forename: Eugene C
authors.initials: EC
authors.lastname: Butcher
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends; D006801:Humans; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis; D049490:Systems Biology / Q000379:methods / Q000639:trends*; D013678:Technology, Pharmaceutical / Q000379:methods / Q000639:trends*
chemical_list: D004364:Pharmaceutical Preparations