title: Membrane targeting of endocytic adaptors: cargo and lipid do it together.
abstract: The adaptor complex AP-2 plays an important role in cargo selection and clathrin lattice formation during clathrin-mediated endocytosis. In a recent issue of Molecular Cell, Honing et al. demonstrate that high-affinity AP-2 membrane association is achieved through a combination of low-affinity interactions with membrane phosphoinositides and cargo proteins, regulated by phosphorylation.
authors.affiliation: Arena Pharmaceuticals, San Diego, California 92121, USA.
authors.forename: Ibragim
authors.initials: I
authors.lastname: Gaidarov
authors.forename: James H
authors.initials: JH
authors.lastname: Keen
mesh_terms: D033962:Adaptor Protein Complex 2 / Q000502:physiology*; D000818:Animals; D002966:Clathrin / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology*; D050356:Lipid Metabolism; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D021381:Protein Transport
chemical_list: D033962:Adaptor Protein Complex 2; D002966:Clathrin; D010744:Phosphoric Monoester Hydrolases