Analysis of cytokine levels in cerebrospinal fluid in mumps meningitis: comparison with echovirus type 30 meningitis.
BACKGROUND
It is unclear whether or not the CSF cytokine profiles in viral meningitis differ with the kind of causative virus.


METHODS
We measured the concentrations of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2), IL-4, IL-6, and IL-10 in CSF during the acute stage in 15 children with mumps meningitis (MM), and 34 with echovirus type 30 meningitis (EM).


RESULTS
The CSF IFN-gamma, IL-2, IL-6, and IL-10 levels were elevated in MM, and the CSF IFN-gamma, IL-2, and IL-6 levels were elevated in EM. The CSF IFN-gamma, IL-2, and IL-10 levels in MM were significantly higher than those in EM (p<0.0001, p<0.0001, and p<0.0001, respectively). The CSF IL-6 levels in EM were significantly higher than those in MM (p=0.0255). The CSF TNF-alpha and IL-4 levels were not elevated in MM or EM. In MM, the IL-6 level was correlated with the IL-2 and IL-10 levels in CSF (p=0.0347 and p=0.0120, respectively). In EM, the IFN-gamma level was correlated with the IL-10 level in CSF (p=0.0002).


CONCLUSIONS
CSF cytokine profiles in MM were different from those in EM. Therefore, it is likely that the pathogenesis of MM is different from that of EM.
Ichiyama
Takashi
T
Department of Pediatrics, Yamaguchi University School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan. ichiyama@yamaguchi-u.ac.jp
Maeba
Shinji
S
Suenaga
Naoko
N
Saito
Kumiko
K
Matsubara
Tomoyo
T
Furukawa
Susumu
S
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000134:cerebrospinal fluid*; D029822:Enterovirus B, Human / Q000502:physiology*; D004769:Enterovirus Infections / Q000134:cerebrospinal fluid* / Q000821:virology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008587:Meningitis, Viral / Q000134:cerebrospinal fluid* / Q000821:virology*; D009107:Mumps / Q000134:cerebrospinal fluid* / Q000821:virology; D009109:Mumps virus / Q000502:physiology*
D016207:Cytokines