The effect of HMG and recombinant human FSH on oocyte quality: a randomized single-blind clinical trial.
OBJECTIVE
To compare the effect of HMG and rhFSH on oocyte quality in ICSI cycle.


METHODS
Vali-e-Asr university teaching hospital.


METHODS
Prospective single-blind randomized clinical trial.


METHODS
Sixty women undergoing ovarian stimulation for ICSI were randomized to receive a standard protocol of either HMG or rhFSH in down-regulation cycles.


METHODS
Prior to microinjection, each oocyte was assessed regarding the nuclear maturity, morphology of zona plucida, cytoplasmic appearance and polar body morphology. Fertilization rate was followed.


RESULTS
The percentage of metaphase II oocytes in HMG and rhFSH groups.


METHODS
Statistical analyses were carried out by the Mann-Whitney, Fisher's exact, chi2 tests and Student's t-test.


RESULTS
No significant differences were found between two groups in regard to the demographic data, the ovarian response and pregnancy/implantation rates (P>0.05). The percentage of metaphase II oocytes in HMG and rhFSH groups were 81.3% versus 80.6%, respectively.


CONCLUSIONS
There were no significant differences between parameters such as, oocyte quality and percentage of metaphase II oocytes between these two groups.
Rashidi
Batool Hossein
BH
Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Imam Khomeini Hospital Complex, Keshavarz Blvd., Tehran 14194, Iran.
Sarvi
Fatemeh
F
Tehrani
Ensieh Shahrokh
ES
Zayeri
Farid
F
Movahedin
Mansoureh
M
Khanafshar
Navid
N
D000328:Adult; D010064:Embryo Implantation; D004624:Embryo Transfer; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage*; D006801:Humans; D008596:Menotropins / Q000008:administration & dosage*; D008845:Microinjections; D009865:Oocytes / Q000187:drug effects*; D010062:Ovulation Induction; D011247:Pregnancy; D011446:Prospective Studies; D011994:Recombinant Proteins
D011994:Recombinant Proteins; D008596:Menotropins; D005640:Follicle Stimulating Hormone