TRP channels in airway smooth muscle as therapeutic targets.
Cation channels are of fundamental importance in regulating the function of airway smooth cells especially bronchoconstriction in response to spasmogens, and are therefore key players in the pathogenesis of asthma. To date, the identity of these cation channels remains a mystery. However, the recently emerged transient receptor potential (TRP) cation channel family has provided several promising channel candidates. The identification of the key TRP channels involved in regulating airway smooth muscle contractility, and therefore airway tone, could provide new and exciting prospects for the development of novel therapies for the treatment of airway diseases such as asthma.
Gosling
Martin
M
Novartis Institutes for Biomedical Research, Novartis Respiratory Research Centre, Wimblehurst Road, Horsham, West Sussex, RH12 5AB, UK.
Poll
Chris
C
Li
Su
S
D000818:Animals; D001249:Asthma / Q000188:drug therapy* / Q000378:metabolism; D001993:Bronchodilator Agents / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism*; D012137:Respiratory System / Q000187:drug effects / Q000378:metabolism*; D050051:Transient Receptor Potential Channels / Q000378:metabolism* / Q000502:physiology
D001993:Bronchodilator Agents; D050051:Transient Receptor Potential Channels