title: Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease.
abstract: Analysis of the apolipoprotein E genotype in sibpairs with Parkinson's disease showed the E4 allele was over represented in those who shared the adjacent chromosome 19 markers. This suggests that apolipoprotein E4 is responsible for the linkage peak in this region and that it is a modest risk factor for Parkinson's disease.
authors.affiliation: INSERM EMI00-06, Evry, France.
authors.forename: Maria
authors.initials: M
authors.lastname: Martinez
authors.forename: Alexis
authors.initials: A
authors.lastname: Brice
authors.forename: Jenny R
authors.initials: JR
authors.lastname: Vaughan
authors.forename: Alexander
authors.initials: A
authors.lastname: Zimprich
authors.forename: Monique M B
authors.initials: MM
authors.lastname: Breteler
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Meco
authors.forename: Alessandro
authors.initials: A
authors.lastname: Filla
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Farrer
authors.forename: Christine
authors.initials: C
authors.lastname: Bétard
authors.forename: Andrew
authors.initials: A
authors.lastname: Singleton
authors.forename: John
authors.initials: J
authors.lastname: Hardy
authors.forename: Giuseppe
authors.initials: G
authors.lastname: De Michele
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Bonifati
authors.forename: Ben A
authors.initials: BA
authors.lastname: Oostra
authors.forename: Thomas
authors.initials: T
authors.lastname: Gasser
authors.forename: Nick W
authors.initials: NW
authors.lastname: Wood
authors.forename: Alexandra
authors.initials: A
authors.lastname: Dürr
mesh_terms: D000483:Alleles; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D005192:Family Health; D005787:Gene Frequency; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008126:Lod Score; D018895:Microsatellite Repeats; D010300:Parkinson Disease / Q000235:genetics*; D035781:Siblings
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E