BMP signalling: synergy and feedback create a step gradient.
More than a decade ago, genetic evidence predicted the existence of a Dpp gradient in the early Drosophila embryo. Two recent studies finally reveal Dpp distribution, providing further insights into the mechanism of BMP gradient formation.
Ashe
Hilary L
HL
Faculty of Life Sciences, The University of Manchester, UK. hilary.ashe@manchester.ac.uk
D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D004330:Drosophila / Q000196:embryology* / Q000378:metabolism; D029721:Drosophila Proteins / Q000378:metabolism*; D004625:Embryo, Nonmammalian / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000378:metabolism*
D019485:Bone Morphogenetic Proteins; D029721:Drosophila Proteins; C090409:SCW protein, Drosophila; D016212:Transforming Growth Factor beta; C064196:dpp protein, Drosophila