title: Synthesis of some new biologically active 1,3,4-oxadiazolyl nitroindoles and a modified Fischer indole synthesis of ethyl nitro indole-2-carboxylates.
abstract: An efficient and modified synthesis of ethyl-4-nitro/5-nitro/6-nitro and 7-nitroindole-2-carboxylates is described. Carbohydrazides of corresponding ethyl nitroindole-2-carboxylates underwent smooth one-step transformation to 1,3,4-oxadiazolyl nitroindoles (4a-l) on reaction with aromatic carboxylic acids in the presence of phosphorus oxychloride. An alternate method to synthesize 1,3,4-oxadiazolyl nitroindoles is also described. Among the newly synthesized 1,3,4-oxadiazolyl nitroindoles, a few compounds are studied for anti-inflammatory activity.
authors.affiliation: Department of Post-Graduate Studies and Research in Chemistry, Mangalore University, Mangalagangotri 574 199, India.
authors.forename: B
authors.initials: B
authors.lastname: Narayana
authors.forename: B V
authors.initials: BV
authors.lastname: Ashalatha
authors.forename: K K
authors.initials: KK
authors.lastname: Vijaya Raj
authors.forename: J
authors.initials: J
authors.lastname: Fernandes
authors.forename: B K
authors.initials: BK
authors.lastname: Sarojini
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001391:Azo Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002264:Carboxylic Acids / Q000737:chemistry*; D004487:Edema / Q000473:pathology; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D001391:Azo Compounds; D002264:Carboxylic Acids; D007211:Indoles; C030374:indole; D009584:Nitrogen