title: The cost of steroid-free protocols in primary cadaver kidney transplantation.
abstract: Steroid-free immunosuppression regimens have been enjoying recent success in clinical transplantation. The use of antibodies required for such protocols can be an economic burden. We proposed to study their cost in our center. This retrospective study involved 147 consecutive patients subjected to 4 protocols of immunosuppression. The first received triple therapy. The second group received induction with basiliximab, whereas the third received Basiliximab plus cyclosporine (CSA) plus mycophenolate mofetil (MMF), and the fourth received Thymoglobulin plus CSA plus MMF in conjuction with only 4 days of steroid. Rejection episodes were treated with Solumedrol. Six-month charges were obtained from computerized records of the finance department, the in-house laboratories, and the transplantation service registry. All charges were expressed in 2004 dollars. Statistical analyses were obtained using chi-square, analysis of variance (ANOVA) and Kaplan-Meier tests. The 4 groups were similar with regard to donor and/or recipient gender, race, panel reactive antibodies, cold ischemia, dialysis requirements length of stay and readmission, graft survival, and function. Charges were significantly higher in the last 2 groups as compared with triple therapy.
authors.affiliation: Division of Transplant Surgery and Finance Department, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA. DNghiem@WPAHS.org
authors.forename: D D
authors.initials: DD
authors.lastname: Nghiem
authors.forename: B J
authors.initials: BJ
authors.lastname: Carpenter
authors.forename: J D
authors.initials: JD
authors.lastname: Schlosser
authors.forename: K
authors.initials: K
authors.lastname: Sureshkumar
authors.forename: C A
authors.initials: CA
authors.lastname: Vivas
authors.forename: S E
authors.initials: SE
authors.lastname: Frowen
authors.forename: R J
authors.initials: RJ
authors.lastname: Marcus
mesh_terms: D000328:Adult; D001806:Blood Urea Nitrogen; D002102:Cadaver; D003404:Creatinine / Q000097:blood; D004359:Drug Therapy, Combination; D005260:Female; D006650:Histocompatibility Testing; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery*; D016030:Kidney Transplantation / Q000276:immunology / Q000502:physiology*; D008297:Male; D012086:Reoperation; D012189:Retrospective Studies; D014019:Tissue Donors
chemical_list: D007166:Immunosuppressive Agents; D003404:Creatinine