title: Enantioselective cycloadditions with alpha,beta-disubstituted acrylimides.
abstract: [reaction: see text] The use of N-H imide templates provides a solution to the problem of rotamer control in Lewis acid catalyzed reactions of alpha,beta-disubstituted acryloyl imides. Reactions proceed through the s-cis rotamer and with improved reactivity because A(1,3) strain is avoided. Enantioselective nitrone, nitrile oxide, and Diels-Alder cycloadditions demonstrate the principle.
authors.affiliation: Department of Chemistry, North Dakota State University, Fargo, North Dakota 58105-5516, USA. mukund.sibi@ndsu.edu
authors.forename: Mukund P
authors.initials: MP
authors.lastname: Sibi
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Ma
authors.forename: Kennosuke
authors.initials: K
authors.lastname: Itoh
authors.forename: Prabagaran
authors.initials: P
authors.lastname: Narayanasamy
authors.forename: Craig P
authors.initials: CP
authors.lastname: Jasperse