Solitary metachronous metastasis to the thyroid from renal clear cell carcinoma 19 years after nephrectomy: report of a case.
We report a rare case of a solitary metachronous metastasis of renal clear cell carcinoma (RCC) presenting as a thyroid tumor 19 years after a nephrectomy. Our search of the English-language literature found only sporadic reports of late RCC metastases to the thyroid. Fine-needle aspiration biopsy of the thyroid tumor was not accompanied with thyroglobulin (Tg) staining, leading us to initially suspect a primary follicular thyroid carcinoma. The patient, a 77-year-old man, underwent a total thyroidectomy with modified neck dissection. Histological examination confirmed the tumor to be RCC metastasis, and immunohistochemical analysis revealed that both Tg and thyroid transcription factor-1 (TTF-1) were negative in the tumor cells. Thus, the possibility of late RCC metastasis to the thyroid should be considered, even in a patient with a remote history. Furthermore, TTF-1 is useful for identifying thyroid metastatic carcinomas.
Wada
Nobuyuki
N
Department of General Surgery, Yokohama City University Medical Center, 4-57 Urafune-cho, Yokohama, 232-0024, Japan.
Hirakawa
Shohei
S
Rino
Yasushi
Y
Hasuo
Kimiatsu
K
Kawachi
Kae
K
Nakatani
Yukio
Y
Inui
Kenji
K
Takanashi
Yoshinori
Y
D000368:Aged; D002292:Carcinoma, Renal Cell / Q000556:secondary*; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000401:mortality*; D008197:Lymph Node Excision; D008297:Male; D009687:Nuclear Proteins / Q000378:metabolism; D013954:Thyroglobulin / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D000074482:Thyroid Nuclear Factor 1; D013965:Thyroidectomy; D013997:Time Factors; D014157:Transcription Factors / Q000378:metabolism
C000614412:NKX2-1 protein, human; D009687:Nuclear Proteins; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors; D013954:Thyroglobulin