title: [Use of continuous high-volume hemofiltration in patients with sepsis and multiple organ dysfunction].
abstract: The paper gives the authors' experience in performing continuous high-volume hemofiltration in 38 patients with sepsis and multiple organ failure. The kinetics of proinflammatory cytokines and a number of plasma enzymes as markers of substances having a relatively high molecular mass was studied. The advantages of a procedure using an artificial kidney apparatus equipped with an on-line substituting fluid preparation system are described. The possibilities of correcting the parameters of homeostasis are the principles of maintenance of a hemostatic system in this group of patients during the procedure are presented. The drawbacks of this technique are also described.
authors.forename: L S
authors.initials: LS
authors.lastname: Biriukova
authors.forename: N V
authors.initials: NV
authors.lastname: Purlo
authors.forename: E N
authors.initials: EN
authors.lastname: Denisova
authors.forename: L G
authors.initials: LG
authors.lastname: Mondoev
authors.forename: A A
authors.initials: AA
authors.lastname: Levina
authors.forename: G M
authors.initials: GM
authors.lastname: Galstian
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood; D004798:Enzymes / Q000097:blood; D005260:Female; D006440:Hemofiltration / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D007688:Kidneys, Artificial; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000628:therapy*; D009862:Online Systems; D018805:Sepsis / Q000628:therapy*
chemical_list: D015415:Biomarkers; D016207:Cytokines; D004798:Enzymes