title: [Primary malignant schwannoma of the uterine cervix: a malignant tumor with unusual behaviour. A case report].
abstract: Malignant tumors of peripheral nerves (MPNST) represent approximately 5-10% of all soft tissue sarcomas and usually are in relationship with a major nerve. Primary cervical malignant Schwannomas are very rare neural sheat tumors that, grossly and clinically, are misdiagnosed for other more frequent lesions of the uterine cervix. We report a case of primary cervical malignant Schwannoma in a 27 years old female with atypical bleeding. The lesion is characterized by densely packed spindle cells with nuclear atypia and high mitotic rate. Immuno-histochemical stains are positive for vimentin and S-100 but negative for HMB-45, keratins, desmin and actin. After 34 months the patient is disease free. To our knowledge, this is the seventh case described.
authors.affiliation: Istituto di Anatomia Patologica, P.O. "SS. Annunziata", Chieti, Dipartimento di Oncologia e Neuroscienze, Università "G. d'Annunzio", Chieti-Pescara.
authors.forename: L
authors.initials: L
authors.lastname: Di Giovannantonio
authors.forename: R
authors.initials: R
authors.lastname: Bellocci
authors.forename: R
authors.initials: R
authors.lastname: Zappacosta
authors.forename: B
authors.initials: B
authors.lastname: Zappacosta
authors.forename: A
authors.initials: A
authors.lastname: Castrataro
authors.forename: M
authors.initials: M
authors.lastname: Liberatore
authors.forename: M
authors.initials: M
authors.lastname: Liberati
authors.forename: D
authors.initials: D
authors.lastname: Angelucci
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D009442:Neurilemmoma / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000473:pathology*