title: Shape changes of the corpus callosum in abstinent methamphetamine users.
abstract: The objective of the current study was to evaluate structural changes of the corpus callosum (CC) in abstinence methamphetamine (MA) users. Shape and size of the CC in 27 MA users were compared to those of 18 healthy comparison subjects. To define the local curvature and width of the CC, medial model-based shape analysis was performed using CC skeletons extracted from a distance map. To define the local displacement of the CC, a boundary model-based shape analysis was performed. In addition, the size of regional areas of the CC was measured according to the Witelson's definition for comparison. In the medial model-based shape analysis, increased curvature in the genu (curvature angle difference = 4.1 degrees) and decreased width in posterior midbody (width difference = 0.77 mm) and isthmus area (width difference = 0.86 mm) of the CC were observed in MA users relative to healthy comparison subjects. In the boundary model-based shape analysis, significant displacement was observed in MA users where there were differences in shape/width patterns by the medial model-based shape analysis. There were no differences in the size of regional areas of the CC between groups. Findings suggest that MA use is associated with regional changes in interhemispheric white matter tracts, which connect frontal and parietal cortices and that these frontal and parietal abnormalities may underlie clinical manifestations of the MA abuse.
authors.affiliation: Interdisciplinary Program in Medical and Biological Engineering, Seoul National University, 28 Yongun-dong Chongno-gu, Seoul, South Korea.
authors.forename: Jungsu S
authors.initials: JS
authors.lastname: Oh
authors.forename: In Kyoon
authors.initials: IK
authors.lastname: Lyoo
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Sung
authors.forename: Jaeuk
authors.initials: J
authors.lastname: Hwang
authors.forename: Jihyun
authors.initials: J
authors.lastname: Kim
authors.forename: Ain
authors.initials: A
authors.lastname: Chung
authors.forename: Kwang Suk
authors.initials: KS
authors.lastname: Park
authors.forename: Seog Ju
authors.initials: SJ
authors.lastname: Kim
authors.forename: Perry F
authors.initials: PF
authors.lastname: Renshaw
authors.forename: In Chan
authors.initials: IC
authors.lastname: Song
mesh_terms: D000328:Adult; D019969:Amphetamine-Related Disorders / Q000473:pathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D003337:Corpus Callosum / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male