The role of D-dimer and residual venous obstruction in recurrence of venous thromboembolism after anticoagulation withdrawal in cancer patients.
We assessed the predictive value of D-dimer (D-d) and residual venous obstruction (RVO), alone or in combination, for recurrent venous thromboembolism (VTE) over a 2-year follow-up in a cohort of 88 cancer patients after oral anticoagulant therapy (OAT) withdrawal following a first episode of proximal deep vein thrombosis of the lower limbs. RVO, determined by compression ultrasonography on the day of OAT suspension (T1), and abnormal D-d (cut-off value: 500 ng/mL), measured at T1 and 30+/-10 days afterwards, are independent risk factors for recurrent VTE in cancer patients.
Cosmi
Benilde
B
Legnani
Cristina
C
Cini
Michela
M
Guazzaloca
Giuliana
G
Palareti
Gualtiero
G
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D015897:Comorbidity; D004198:Disease Susceptibility; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D012008:Recurrence; D019851:Thrombophilia / Q000097:blood / Q000150:complications / Q000453:epidemiology; D013924:Thrombophlebitis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000517:prevention & control; D014463:Ultrasonography
D000925:Anticoagulants; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D