[A comparative study of antistroke activity of the new drug "cerebral" and its fractions in rats].
The effect of the new drug "cerebral" and its fractions 1-3 on the model of bilateral hemorrhagic stroke in white rats was studied with reference to the action of cebrolysin and cerebrolysate-M. With respect to the general functional state, behavioral activity restoration, and morphological data, the most pronounced antistroke action was observed for the cerebral-1 fraction. This fraction was further separated into three subfractions. The most promising test results were obtained for the 1.2 subfraction, which was selected for the further investigation.
Makarenko
A N
AN
Kositsin
N S
NS
Nazimov
I V
IV
Svinov
M M
MM
Goloborod'ko
E V
EV
Pasikova
N V
NV
D000281:Administration, Intranasal; D000596:Amino Acids / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002543:Cerebral Hemorrhage / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification*; D051381:Rats; D017208:Rats, Wistar
D000596:Amino Acids; D018696:Neuroprotective Agents; C006952:cerebrolysin