title: DNA binding specificity and cytotoxicity of novel antitumor agent Ge132 derivatives.
abstract: A series of Ge132 derivatives have shown enhanced antitumor activity. Previous studies suggest that DNA can be their primary target. Here we show direct evidence that two newly synthesized Ge132 derivatives can intercalate into DNA. Unexpected methyl substitution effect of the novel derivatives on DNA sequence selectivity and cytotoxicity was observed.
authors.affiliation: Division of Biological Inorganic Chemistry, Key Laboratory of Rare Earth Chemistry and Physics, Graduate School of the Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Shangguan
authors.forename: Feifei
authors.initials: F
authors.lastname: Xing
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
authors.forename: Jianhua
authors.initials: J
authors.lastname: Mao
authors.forename: Dan
authors.initials: D
authors.lastname: Zhao
authors.forename: Xuejian
authors.initials: X
authors.lastname: Zhao
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism*; D002417:Cattle; D002453:Cell Cycle / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004354:Drug Screening Assays, Antitumor; D005857:Germanium; D006801:Humans; D020128:Inhibitory Concentration 50; D007364:Intercalating Agents / Q000378:metabolism*; D008297:Male; D009942:Organometallic Compounds / Q000378:metabolism*; D011422:Propionates; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D011804:Quinolines / Q000737:chemistry / Q000378:metabolism; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D007364:Intercalating Agents; D009942:Organometallic Compounds; D011422:Propionates; D011804:Quinolines; D005857:Germanium; C066750:propagermanium; D004247:DNA