title: p-Aminobenzoic acid derivatives as acetylcholinesterase inhibitors.
abstract: Because Alzheimer's disease (AD) is a medical problem characterized by progressive loss of memory and cognition that is associated with a deficient cholinergic system, this work aims to evaluate some p-aminobenzoic acid (PABA) derivatives as acetylcholinesterase inhibitors in vitro, in continuation with our last studies. The assayed compounds are low toxic, simple-structured and low cost.
authors.affiliation: Sección de Graduados y Departamento de Bioquímica, Escuela Superior de Medicina del Instituto Politécnico Nacional, Apartado Postal 42-161, C.P. 11340, Mexico City, Mexico.
authors.forename: José
authors.initials: J
authors.lastname: Correa-Basurto
authors.forename: Iván Vázquez
authors.initials: IV
authors.lastname: Alcántara
authors.forename: L Michel
authors.initials: LM
authors.lastname: Espinoza-Fonseca
authors.forename: José G
authors.initials: JG
authors.lastname: Trujillo-Ferrara
mesh_terms: D010129:4-Aminobenzoic Acid / Q000138:chemical synthesis* / Q000494:pharmacology; D000110:Acetylcholinesterase / Q000187:drug effects; D000544:Alzheimer Disease / Q000188:drug therapy; D000818:Animals; D001665:Binding Sites; D002417:Cattle; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D008958:Models, Molecular
chemical_list: D002800:Cholinesterase Inhibitors; D000110:Acetylcholinesterase; D010129:4-Aminobenzoic Acid