[Cytostatic effects of bifolar and chlofiden. Effect on protein synthesis and cell cycle].
Study of influence of new antitumor preparations bifolar and chlofiden on rat liver protein biosynthesis in vivo and on sarcoma-45 in vitro was carried out using labeled precursor 3H-leucine. It was shown that the preparations inhibited protein synthesis in normal and malignant tissues. Mitotic cycle and its phases were investigated with 3H-tymedin. It was established that bifolar influenced all the phases of mitotic cycle and the sensitive phases of the mitosis itself, which are connected with the redistribution of genetic material.
Sharykina
N I
NI
Bukhtiarova
T A
TA
Kudriavtseva
I G
IG
Pavlovskaia
G P
GP
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D005021:Ethylamines / Q000494:pharmacology* / Q000627:therapeutic use; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008938:Mitosis / Q000187:drug effects*; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D009368:Neoplasm Transplantation; D010752:Phosphoramide Mustards / Q000494:pharmacology* / Q000627:therapeutic use; D014176:Protein Biosynthesis / Q000187:drug effects*; D051381:Rats; D012513:Sarcoma, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D013997:Time Factors
D000970:Antineoplastic Agents; C480822:Chlofiden; D005021:Ethylamines; D009363:Neoplasm Proteins; D010752:Phosphoramide Mustards; C003705:Preparation F-11