title: Functional features of human CD25+ regulatory thymocytes.
abstract: Two families of Treg cells have been described and named "naturally occurring" and "adaptive" regulatory T cells. The naturally occurring Treg cells arise in the thymus, where they achieve their complete functional maturation, whereas the adaptive Treg cells derive from the thymus too, but achieve their functional maturation in the periphery. This review discusses the phenotype and the functional features of the human naturally occurring CD25+ regulatory thymocytes.
authors.affiliation: Center for Research, Transfer, High Education MCIDNENT, University of Florence, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Liotta
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Cosmi
authors.forename: Paola
authors.initials: P
authors.lastname: Romagnani
authors.forename: Enrico
authors.initials: E
authors.lastname: Maggi
authors.forename: Sergio
authors.initials: S
authors.lastname: Romagnani
authors.forename: Francesco
authors.initials: F
authors.lastname: Annunziato
mesh_terms: D001327:Autoimmune Diseases / Q000276:immunology; D006801:Humans; D010641:Phenotype; D015375:Receptors, Interleukin-2 / Q000502:physiology*; D013601:T-Lymphocytes / Q000502:physiology*; D013950:Thymus Gland / Q000166:cytology
chemical_list: D015375:Receptors, Interleukin-2