title: [Hepatoprotectors prevent the toxic action of cyclophosphamide on the liver of rats with CCl4-induced hepatitis model].
abstract: The results of experiments on white rats with CCl4-induced hepatitis showed that the combined introduction of cyclophosphamide and hepatoprotectors of the plant origin (lochein, maksar, silimarin) leads to a decrease in acute toxicity and to less pronounced manifestations of hepatotoxicity of cyclophosphamide. Hepatoprotectors decrease the activity of aminotransferases, reduce the level of bilirubin, normalize the content of protein andpipids in the blood serum, and suppress the development of morphological disorders in the liver.
authors.forename: A V
authors.initials: AV
authors.lastname: Rat'kin
authors.forename: A S
authors.initials: AS
authors.lastname: Saratikov
authors.forename: V S
authors.initials: VS
authors.lastname: Chuchalin
authors.forename: V N
authors.initials: VN
authors.lastname: Burkova
authors.forename: V N
authors.initials: VN
authors.lastname: Frolov
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000503:physiopathology; D003520:Cyclophosphamide / Q000633:toxicity*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats
chemical_list: D010936:Plant Extracts; D003520:Cyclophosphamide; D002251:Carbon Tetrachloride