title: Spectrophotometric skin measurements correlate with EORTC/RTOG-common toxicity criteria.
abstract: OBJECTIVE
  It was investigated whether the elementary EORTC/RTOG-CTC score (Common Toxicity Criteria) for radiotherapy skin reactions correlates with spectrophotometric measurements of the skin color. PATIENTS, MATERIAL, AND METHODS: In 41 patients irradiated for unilateral breast cancer the regular scoring by CTC was done during radiotherapy. In parallel, a total of 4,920 spectrophotometric measurements to determine the skin color were performed at baseline, at the beginning of radiotherapy, and at 20, 40 and 60 Gy. The nonirradiated contralateral breast was used for control measurements.
  
  
  RESULTS
  As expected, the skin color (especially red) depended on the radiation dose applied to the skin. The objective spectrophotometric measurements were found to correlate well with the subjective CTC scores.
  
  
  CONCLUSIONS
  For classification of acute radiation toxicity there seems to be no need to replace the common CTC scoring by technical methods.
authors.affiliation: Department of Radiotherapy, University Hospital Freiburg, Freiburg i. Br., Germany. momm@mst1.ukl.uni-freiburg.de
authors.forename: Felix
authors.initials: F
authors.lastname: Momm
authors.forename: Susanne
authors.initials: S
authors.lastname: Bartelt
authors.forename: Kristine
authors.initials: K
authors.lastname: Haigis
authors.forename: Astrid
authors.initials: A
authors.lastname: Grosse-Sender
authors.forename: Gerlo
authors.initials: G
authors.lastname: Witucki
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010315:Particle Accelerators; D017698:Postmenopause; D011878:Radiotherapy / Q000379:methods; D011879:Radiotherapy Dosage; D012867:Skin / Q000528:radiation effects*; D013053:Spectrophotometry