title: Xlr3b is a new imprinted candidate for X-linked parent-of-origin effects on cognitive function in mice.
abstract: Imprinted genes show differential expression between maternal and paternal alleles as a consequence of epigenetic modification that can result in 'parent-of-origin' effects on phenotypic traits. There is increasing evidence from mouse and human studies that imprinted genes may influence behavior and cognitive functioning. Previous work in girls with Turner syndrome (45,XO) has suggested that there are X-linked parent-of-origin effects on brain development and cognitive functioning, although the interpretation of these data in terms of imprinted gene effects has been questioned. We used a 39,XO mouse model to examine the influence of the parental origin of the X chromosome on cognitive behaviors and expression of X-linked genes in brain. Our findings confirm the existence of X-linked imprinted effects on cognitive processes and identify a new maternally expressed imprinted gene candidate on the X chromosome, Xlr3b, which may be of importance in mediating the behavioral effects.
authors.affiliation: Laboratories of Cognitive and Behavioral Neuroscience and Developmental Genetics and Imprinting, The Babraham Institute, The Babraham Research Campus, Cambridge, CB2 4AT, UK.
authors.forename: William
authors.initials: W
authors.lastname: Davies
authors.forename: Anthony
authors.initials: A
authors.lastname: Isles
authors.forename: Rachel
authors.initials: R
authors.lastname: Smith
authors.forename: Delicia
authors.initials: D
authors.lastname: Karunadasa
authors.forename: Doreen
authors.initials: D
authors.lastname: Burrmann
authors.forename: Trevor
authors.initials: T
authors.lastname: Humby
authors.forename: Obah
authors.initials: O
authors.lastname: Ojarikre
authors.forename: Carol
authors.initials: C
authors.lastname: Biggin
authors.forename: David
authors.initials: D
authors.lastname: Skuse
authors.forename: Paul
authors.initials: P
authors.lastname: Burgoyne
authors.forename: Lawrence
authors.initials: L
authors.lastname: Wilkinson
mesh_terms: D000818:Animals; D003071:Cognition; D005260:Female; D018392:Genomic Imprinting; D008297:Male; D051379:Mice; D009687:Nuclear Proteins / Q000235:genetics*; D014960:X Chromosome
chemical_list: D009687:Nuclear Proteins; C091490:Xlr3 protein, mouse