Antimicrobial terpenoids from Pterocarpus indicus.
A mixture of loliolide 1 (> 85%) and paniculatadiol 2 (< 15%) was obtained from the ethyl acetate leaf extract of Pterocarpus indicus by silica gel chromatography, while the air-dried flowers afforded lupeol 3 and phytol esters 4. The structures of 1-4 were determined by NMR spectroscopy. Antimicrobial tests on a mixture of 1 and 2 indicated that it has moderate activity against Candida albicans and low activity against Pseudomonas aeruginosa, Escherichia coli, and Aspergillus niger. It was found inactive against Staphylococcus aureus, Bacillus subtilis, and Trichophyton mentagrophytes.
Ragasa
Consolacion Y
CY
Chemistry Department, De La Salle University, 2401 Taft Avenue, Manila 1004, Philippines. sagasac@dlsu.edu.ph
De Luna
Roderick D
RD
Hofilena
Joy G
JG
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001572:Benzofurans / Q000737:chemistry / Q000494:pharmacology; D035264:Flowers / Q000737:chemistry; D005658:Fungi / Q000187:drug effects; D015394:Molecular Structure; D053978:Pentacyclic Triterpenes; D018515:Plant Leaves / Q000737:chemistry; D035721:Pterocarpus / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology; D000094042:Lupanes
D000890:Anti-Infective Agents; D001572:Benzofurans; D053978:Pentacyclic Triterpenes; D013729:Terpenes; D014315:Triterpenes; C503377:paniculatadiol; C010480:lupeol; D000094042:Lupanes; C030425:loliolide