title: In vitro activity of telithromycin against macrolide-susceptible and macrolide-resistant pharyngeal isolates of group A streptococci in the United States.
abstract: In vitro susceptibility testing of 2,797 group A streptococcus (GAS) isolates demonstrated that telithromycin was fully active against all macrolide-susceptible strains and among 80 of 115 macrolide-resistant GAS expressing the M phenotype. Telithromycin resistance was identified in 2 of 45 strains expressing the inducible macrolide-lincosamide-streptogramin B phenotype and four of nine isolates expressing the constitutive macrolide-lincosamide-streptogramin B resistance phenotype.
authors.affiliation: Department of Pediatrics, MPH Division of Allergy, Immunology and Infectious Diseases, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA. michael.green@chp.edu
authors.forename: Michael
authors.initials: M
authors.lastname: Green
authors.forename: Coburn
authors.initials: C
authors.lastname: Allen
authors.forename: John
authors.initials: J
authors.lastname: Bradley
authors.forename: Barry
authors.initials: B
authors.lastname: Dashefsky
authors.forename: Janet R
authors.initials: JR
authors.lastname: Gilsdorf
authors.forename: Mario J
authors.initials: MJ
authors.lastname: Marcon
authors.forename: Gordon E
authors.initials: GE
authors.lastname: Schutze
authors.forename: Clay
authors.initials: C
authors.lastname: Smith
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Walter
authors.forename: Judith M
authors.initials: JM
authors.lastname: Martin
authors.forename: Kathryn A
authors.initials: KA
authors.lastname: Edwards
authors.forename: Karen A
authors.initials: KA
authors.lastname: Barbadora
authors.forename: Renee M
authors.initials: RM
authors.lastname: Rumbaugh
authors.forename: Ellen R
authors.initials: ER
authors.lastname: Wald
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006801:Humans; D048628:Ketolides / Q000494:pharmacology*; D018942:Macrolides / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010614:Pharynx / Q000382:microbiology*; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000302:isolation & purification; D014481:United States
chemical_list: D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides; C106791:telithromycin