Protein microarray for profiling antibody responses to Yersinia pestis live vaccine.
A protein microarray representing 149 Yersinia pestis proteins was developed to profile antibody responses in EV76-immunized rabbits. Antibodies to 50 proteins were detected. There are 11 proteins besides F1 and V antigens to which the predominant antibody response occurred, and these proteins show promise for further evaluation as candidates for subunit vaccines and/or diagnostic antigens.
Li
Bei
B
Laboratory of Analytical Microbiology, National Center for Biomedical Analysis, Army Center for Microbial Detection and Research, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Jiang
Lingxiao
L
Song
Qifeng
Q
Yang
Junxin
J
Chen
Zeliang
Z
Guo
Zhaobiao
Z
Zhou
Dongsheng
D
Du
Zongmin
Z
Song
Yajun
Y
Wang
Jin
J
Wang
Hongxia
H
Yu
Shouyi
S
Wang
Jian
J
Yang
Ruifu
R
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood*; D000942:Antigens, Bacterial / Q000276:immunology; D007114:Immunization; D010931:Plague Vaccine / Q000276:immunology*; D040081:Protein Array Analysis; D011817:Rabbits; D015010:Yersinia pestis / Q000276:immunology*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D010931:Plague Vaccine