[Antiresorptive therapy for osteoporosis and bone quality].
In high turnover osteoporosis antiresorptive therapy is effective in increasing the stiffness and the toughness (bone strength) by increasing the mean degree of mineralization of bone tissue through the prolongation of secondary mineralization. But the long-term use of antiresorber would result in highly mineralized bone and disturbed repair of microcracks by inhibition of bone remodeling. Intermittent use of antiresorber could be recommended to avoid the deterioration of bone quality.
Kishimoto
Hideaki
H
Department of Orthopedic Surgery, San-in Rosai Hospital.
D016723:Bone Remodeling; D001862:Bone Resorption / Q000188:drug therapy*; D001842:Bone and Bones / Q000187:drug effects*; D002113:Calcification, Physiologic / Q000187:drug effects; D006801:Humans; D010024:Osteoporosis / Q000188:drug therapy*