title: Metabolic adaptation at birth.
abstract: After birth, the neonate must make a transition from the assured continuous transplacental supply of glucose to a variable fat-based fuel economy. The normal infant born at term accomplishes this transition through a series of well-coordinated metabolic and hormonal adaptive changes. The patterns of adaptation in the preterm infant and the baby born after intrauterine growth restriction are, however, different to that of a full-term neonate, with the risk for former groups that there will be impaired counter-regulatory ketogenesis. There is much less precise linkage of neonatal insulin secretion to prevailing blood glucose concentrations. These patterns of metabolic adaptation are further influenced by feeding practices.
authors.affiliation: Newcastle Neonatal Services, Royal Victoria Infirmary, Department of Child Health, Queen Victoria Road, Newcastle upon Tyne NE1 4 LP, UK. m.p.ward-platt@ncl.ac.uk
authors.forename: Martin
authors.initials: M
authors.lastname: Ward Platt
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Deshpande
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D001786:Blood Glucose / Q000032:analysis; D001903:Bottle Feeding; D001942:Breast Feeding; D005947:Glucose / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn / Q000378:metabolism*; D007234:Infant, Premature / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007657:Ketone Bodies / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D007328:Insulin; D007657:Ketone Bodies; D005947:Glucose