[Obesity and osteoporosis].
Atherosclerosis is a chronic inflammatory disease associated with an elevation of inflammatory markers such as CRP -- a robust predictor of cardiovascular events. Inflammation also plays a pivotal role in the pathogenesis of osteoporosis. IL-6 proved to be the most important predictor of bone loss in the proximal femur. Adipocyte-produced inflammatory cytokines are the pathogenetic link between obesity and its metabolic consequences. The different components of the metabolic syndrome are at the same time well-established risk factors for osteoporosis. Physical training, weight loss, and a Mediterranean-style diet all have a proven cytokine-lowering effect. Contrary to muscle mass, adipose tissue if at all contributes only marginally to the preservation of bone. As a consequence, increasing lean body mass while reducing fat mass seems to be the most effective way to prevent both atherosclerosis and osteoporosis.
Friebe
H
H
Reha-Klinik Aukammtal, Wiesbaden. h.friebe@rmkliniken.de
Peters
A
A
D001161:Arteriosclerosis / Q000276:immunology* / Q000517:prevention & control*; D015984:Causality; D002986:Clinical Trials as Topic; D015897:Comorbidity; D004035:Diet Therapy / Q000379:methods; D005081:Exercise Therapy / Q000379:methods; D006801:Humans; D015994:Incidence; D009765:Obesity / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control*; D010024:Osteoporosis / Q000276:immunology* / Q000517:prevention & control*; D010818:Practice Patterns, Physicians'; D015995:Prevalence; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D016896:Treatment Outcome