title: Ocular syphilis: the new epidemic.
abstract: OBJECTIVE
  To present the clinical presentation, diagnosis, and management of syphilitic uveitis in the context of an epidemic of syphilis in the UK.
  
  
  METHODS
  Retrospective clinical case series.
  
  
  RESULTS
  Six new cases of syphilitic uveitis presented to the Manchester Uveitis Clinic in 2004, after a 15-fold increase in the incidence of syphilis in the UK, including 615 cases in Greater Manchester in the 5 years to 2004. Four cases had secondary syphilis, two had latent disease, two had no rash, and two were HIV positive. Ocular involvement included anterior or panuveitis, retinitis, retinal vasculitis, and papillitis. All resolved on treatment including intramuscular procaine penicillin G with oral probenecid.
  
  
  CONCLUSIONS
  Syphilis is much more common recently and syphilitic uveitis should be considered in all patients with rash and/or headache, where there is retinitis and/or retinal vasculitis, or in any uveitis of uncertain origin. Treatment is that of neurosyphilis.
authors.affiliation: Manchester Royal Eye Hospital, Manchester, UK.
authors.forename: J P
authors.initials: JP
authors.lastname: Doris
authors.forename: K
authors.initials: K
authors.lastname: Saha
authors.forename: N P
authors.initials: NP
authors.lastname: Jones
authors.forename: A
authors.initials: A
authors.lastname: Sukthankar
mesh_terms: D000328:Adult; D004196:Disease Outbreaks; D015818:Eye Infections, Bacterial / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012173:Retinitis / Q000175:diagnosis* / Q000382:microbiology; D012189:Retrospective Studies; D013587:Syphilis / Q000175:diagnosis* / Q000453:epidemiology; D006113:United Kingdom / Q000453:epidemiology; D014605:Uveitis / Q000175:diagnosis* / Q000382:microbiology; D014792:Visual Acuity