title: Molecular identification of an invasive gingival bacterial community.
abstract: A woman with neutropenia developed gingival hyperplasia. Biopsy showed invasion of gingival tissue with mats of filamentous organisms, and molecular analysis by polymerase chain reaction and fluorescence in situ hybridization revealed Capnocytophaga sputigena, Leptotrichia species, and Fusobacterium nucleatum. Oral bacterial flora may cause invasive gingival disease with hyperplasia in immunocompromised patients.
authors.affiliation: Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA. dfredric@fhcrc.org
authors.forename: David N
authors.initials: DN
authors.lastname: Fredricks
authors.forename: Mark M
authors.initials: MM
authors.lastname: Schubert
authors.forename: David
authors.initials: D
authors.lastname: Myerson
mesh_terms: D002206:Capnocytophaga / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D004269:DNA, Bacterial / Q000032:analysis; D004275:DNA, Ribosomal / Q000032:analysis; D005260:Female; D016967:Fusobacterium nucleatum / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D005881:Gingiva / Q000382:microbiology*; D005885:Gingival Hyperplasia / Q000382:microbiology*; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D045183:Leptotrichia / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D008875:Middle Aged; D009503:Neutropenia / Q000150:complications; D016133:Polymerase Chain Reaction / Q000379:methods*; D012336:RNA, Ribosomal, 16S / Q000235:genetics
chemical_list: D004269:DNA, Bacterial; D004275:DNA, Ribosomal; D012336:RNA, Ribosomal, 16S