Sp1-like transcription factors are regulators of embryonic development in vertebrates.
Sp1-like family is an expanding transcription factor family. Members of this family bind to the GC-box or GT-box elements in the promoter/enhancers and regulate the expression of the target genes. Currently, this family consists of at least nine members, which may act as a transactivator or a repressor on target promoters. Sp1-like transcription factors are expressed during development of vertebrate embryos in ubiquitous or tissue-specific manners and play various roles in embryonic development. This review mainly summarises their expression patterns and functions during vertebrate embryogenesis.
Zhao
Chengtian
C
Laboratory of Developmental Biology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.
Meng
Anming
A
D000818:Animals; D047108:Embryonic Development / Q000235:genetics*; D016329:Sp1 Transcription Factor / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*; D014714:Vertebrates / Q000196:embryology* / Q000235:genetics
D016329:Sp1 Transcription Factor; D014157:Transcription Factors