Search for new lead structures for low-molecular-weight immune response modifiers.
In this report we describe different types of 5-amino-3-methylisoxazolo-4-carboxylic acid amides and 5-amino-3-methylisoxazolo-4-ureilenes and their immunological activities. The immunoregulatory activities were tested in the humoral and cellular immune response in mice. The compounds exhibited both immunostimulatory and immunosuppressory activities.
Ryng
Stanisław
S
Wrocław Medical University, Faculty of Pharmacy Dept. Organic Chemistry, 9 Grodzka Str., 50-137 Wrocław, Poland. saryng@bf.uni.wroc.pl
Zimecki
Michał
M
D000577:Amides / Q000138:chemical synthesis*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D015195:Drug Design; D007111:Immunity, Cellular / Q000187:drug effects; D007155:Immunologic Factors / Q000737:chemistry* / Q000494:pharmacology*; D007202:Indicators and Reagents; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D051379:Mice; D008808:Mice, Inbred CBA; D008970:Molecular Weight; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*
D000577:Amides; D007155:Immunologic Factors; D007202:Indicators and Reagents; D007555:Isoxazoles; D014508:Urea