Mutational escape from CD8+ T cell immunity: HCV evolution, from chimpanzees to man.
The mechanisms by which the hepatitis C virus (HCV) establishes persistence are not yet fully understood. Previous chimpanzee and now human studies suggest that mutations within MHC class I-restricted HCV epitopes might contribute to viral escape from cytotoxic T lymphocyte (CTL) responses. However, there are several outstanding questions regarding the role of escape mutations in viral persistence and their fate in the absence of immune selection pressure.
Bowen
David G
DG
Center for Vaccines and Immunity, Columbus Children's Research Institute, Columbus, OH 43205, USA.
Walker
Christopher M
CM
D000818:Animals; D016525:Antigenic Modulation / Q000235:genetics*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D018984:Epitopes, T-Lymphocyte / Q000235:genetics / Q000276:immunology; D019143:Evolution, Molecular; D016174:Hepacivirus / Q000235:genetics / Q000276:immunology*; D006526:Hepatitis C / Q000276:immunology*; D018936:Hepatitis C Antigens / Q000235:genetics / Q000276:immunology; D006801:Humans; D009154:Mutation; D002679:Pan troglodytes / Q000235:genetics / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D018984:Epitopes, T-Lymphocyte; D018936:Hepatitis C Antigens