title: Endoglin gene insertion polymorphism not associated with aneurysmal subarachnoid hemorrhage.
abstract: OBJECTIVE
  Data concerning an association between the ENG gene intronic insertion polymorphism and intracrahial aneurysms (IAs) remain inconsistent. In this study the authors investigated whether this polymorphism is associated with a subarachnoid hemorrhage (SAH) caused by a ruptured IA in a Polish population.
  
  
  METHODS
  One hundred nineteen patients with aneurysmal SAH and 119 sex-matched healthy volunteers were studied. The insertion ENG gene polymorphism in intron 7 was identified using polymerase chain reaction-single-strand chain polymorphism method. The distribution of the insertion allele did not differ between the SAH (13%) and control (16%) cases (p = 0.36). The homozygous insertion/insertion genotype frequencies in these cases were 3.4 and 0.8%, respectively (p = 0.18).
  
  
  CONCLUSIONS
  The authors failed to find an association between the intronic insertion polymorphism of the ENG gene and aneurysmal SAH in a Polish population.
authors.affiliation: Department of Neurology, Jagiellonian University, Krakow, Poland. pera@su.krakow.pl
authors.forename: Joanna
authors.initials: J
authors.lastname: Pera
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Slowik
authors.forename: Tomasz
authors.initials: T
authors.lastname: Dziedzic
authors.forename: Anna
authors.initials: A
authors.lastname: Borratynska
authors.forename: Teresa M
authors.initials: TM
authors.lastname: Rog
authors.forename: Marek
authors.initials: M
authors.lastname: Betlej
authors.forename: Ryszard
authors.initials: R
authors.lastname: Czepko
authors.forename: Andrzej
authors.initials: A
authors.lastname: Szczudlik
mesh_terms: D015703:Antigens, CD; D000071063:Endoglin; D005260:Female; D006801:Humans; D007438:Introns / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011044:Poland; D011110:Polymorphism, Genetic; D011956:Receptors, Cell Surface; D013345:Subarachnoid Hemorrhage / Q000235:genetics*; D019010:Vascular Cell Adhesion Molecule-1 / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface; D019010:Vascular Cell Adhesion Molecule-1