Ultra-short metformin pretreatment for clomiphene citrate-resistant polycystic ovary syndrome.
OBJECTIVE
To evaluate the effect of ultra-short (12 days) metformin pretreatment in clomiphene-citrate (CC) resistant polycystic ovary syndrome (PCOS).


METHODS
Eighty women with CC-resistant PCOS were randomly allocated to metformin pretreatment or usual treatment. Forty women received 1500 mg metformin daily for 12 days, followed by clomiphene 150 mg daily for 5 days along with metformin. Forty women (control group) received the same dose of clomiphene but no metformin pretreatment.


RESULTS
In the metformin group, 17 (42.5%) women ovulated, and 6 (15%) conceived. In the control group, 5 (12.5%) women ovulated but none conceived. Compared with the control group, the metformin group had significantly higher ovulation (P = 0.03) and pregnancy rates (P = 0.026).


CONCLUSIONS
Twelve days of metformin pretreatment improves ovulation and pregnancy rates in women with CC-resistant PCOS.
Hwu
Y M
YM
Department of Obstetrics and Gynecology, Mackay Memorial Hospital, No.92, Section 2, Chung-Shan North Road, Taipei, Taiwan. hu4416@yahoo.com
Lin
S Y
SY
Huang
W Y
WY
Lin
M H
MH
Lee
R K K
RK
D000328:Adult; D002996:Clomiphene / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008687:Metformin / Q000008:administration & dosage / Q000627:therapeutic use*; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy* / Q000473:pathology; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D016896:Treatment Outcome
D005300:Fertility Agents, Female; D002996:Clomiphene; D008687:Metformin