An anionic strategy for three- and four-component coupling reactions leading to ketone frameworks based on vinylogous conversion of dilithio ketone alpha,beta-dianions.
[reaction: see text] Ketone alpha,delta-dianions are generated by vinylogous extension of ketone alpha,beta-dianions with alkenes such as vinylarenes, vinylsilanes, and vinyl sulfides, which then undergo reactions at the delta and alpha positions with different electrophiles, creating ketone frameworks. This work represents a cascade-type anion method that achieved three- and four-carbon component assembly reactions leading to ketones.
Yamato
Shin-ya
SY
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
Yamamura
Go-hei
GH
Komatsu
Mitsuo
M
Arai
Masashi
M
Fukuyama
Takahide
T
Ryu
Ilhyong
I