Cilia and the cell cycle?
A recent convergence of data indicating a relationship between cilia and proliferative diseases, such as polycystic kidney disease, has revived the long-standing enigma of the reciprocal regulatory relationship between cilia and the cell cycle. Multiple signaling pathways are localized to cilia in mammalian cells, and some proteins have been shown to act both in the cilium and in cell cycle regulation. Work from the unicellular alga Chlamydomonas is providing novel insights as to how cilia and the cell cycle are coordinately regulated.
Quarmby
Lynne M
LM
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada. Quarmby@sfu.ca
Parker
Jeremy D K
JD
D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D002696:Chlamydomonas / Q000378:metabolism; D002923:Cilia / Q000502:physiology*; D006801:Humans; D010770:Phosphotransferases / Q000378:metabolism; D007690:Polycystic Kidney Diseases / Q000378:metabolism / Q000503:physiopathology; D015398:Signal Transduction / Q000502:physiology
D018797:Cell Cycle Proteins; D010770:Phosphotransferases