Functional features of human CD25+ regulatory thymocytes.
Two families of Treg cells have been described and named "naturally occurring" and "adaptive" regulatory T cells. The naturally occurring Treg cells arise in the thymus, where they achieve their complete functional maturation, whereas the adaptive Treg cells derive from the thymus too, but achieve their functional maturation in the periphery. This review discusses the phenotype and the functional features of the human naturally occurring CD25+ regulatory thymocytes.
Liotta
Francesco
F
Center for Research, Transfer, High Education MCIDNENT, University of Florence, Italy.
Cosmi
Lorenzo
L
Romagnani
Paola
P
Maggi
Enrico
E
Romagnani
Sergio
S
Annunziato
Francesco
F
D001327:Autoimmune Diseases / Q000276:immunology; D006801:Humans; D010641:Phenotype; D015375:Receptors, Interleukin-2 / Q000502:physiology*; D013601:T-Lymphocytes / Q000502:physiology*; D013950:Thymus Gland / Q000166:cytology
D015375:Receptors, Interleukin-2