title: An anti-staphylococcal acylphloroglucinol from Hypericum foliosum.
abstract: An investigation into the antibacterial properties of Hypericum foliosum Aiton. (Guttiferae) has led to the isolation of a new bioactive acylphloroglucinol natural product which by NMR spectroscopy and mass spectrometry was characterised as 1,3,5-trihydroxy-6-[2''',3'''-epoxy-3'''-methyl-butyl]-2-[2''-methyl-butanoyl]-4-[3'-methyl-2''-butenyl]-benzene and is described here for the first time. This metabolite was evaluated against a panel of multidrug-resistant strains of Staphylococcus aureus and minimum inhibitory values ranged from 16 to 32 microg/ml.
authors.affiliation: Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK. simon.gibbons@ulsop.ac.uk
authors.forename: Simon
authors.initials: S
authors.lastname: Gibbons
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Moser
authors.forename: Sebastian
authors.initials: S
authors.lastname: Hausmann
authors.forename: Michael
authors.initials: M
authors.lastname: Stavri
authors.forename: Eileen
authors.initials: E
authors.lastname: Smith
authors.forename: Christopher
authors.initials: C
authors.lastname: Clennett
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D004852:Epoxy Compounds / Q000302:isolation & purification* / Q000494:pharmacology; D020902:Hypericum / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000302:isolation & purification; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: C503787:1,3,5-trihydroxy-6-(2''',3'''-epoxy-3'''-methyl-butyl)-2-(2''-methyl-butanoyl)-4-(3'-methyl-2''-butenyl)-benzene; D000900:Anti-Bacterial Agents; D004852:Epoxy Compounds; D010936:Plant Extracts; D010696:Phloroglucinol