Synthesis and biological studies of yohimbine derivatives on human alpha2C-adrenergic receptors.
A series of yohimbine derivatives was synthesized and evaluated for binding affinity at the human alpha(2C)-adrenergic receptors expressed in Chinese hamster ovary cells. It has been found that compound 5 shows a higher affinity for alpha(2C)-AR than the parent compound yohimbine 1, thereby illustrating that the nature of the linkers affect binding potencies on these receptors.
Mustafa
Suni M
SM
Department of Pharmaceutical Sciences, University of Tennessee, Health Science Center, Memphis, 38163, USA.
Bavadekar
Supriya A
SA
Ma
Guoyi
G
Moore
Bob M
BM
Feller
Dennis R
DR
Miller
Duane D
DD
D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D006801:Humans; D051379:Mice; D011485:Protein Binding; D018341:Receptors, Adrenergic, alpha-2 / Q000187:drug effects* / Q000378:metabolism; D015016:Yohimbine / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*
D018341:Receptors, Adrenergic, alpha-2; D015016:Yohimbine