title: HIV-associated wasting in the era of highly active antiretroviral therapy: a syndrome of residual HIV infection in monocytes and macrophages?
abstract: Human immunodeficiency virus (HIV) infection in peripheral blood mononuclear cells (PBMCs) might be influencing the development of wasting in the era of potent antiretroviral therapy. In a retrospective study of 57 subjects, HIV proviral DNA levels in PBMCs were higher in subjects whose body weight decreased by >5% one year after initiation of highly active antiretroviral therapy, compared with subjects whose body weight was stable or increased (median HIV proviral DNA load, 8.9 vs. 0.9 copies/10(6) PBMCs; P = .006).
authors.affiliation: Hawaii AIDS Clinical Research Program, John A. Burns School of Medicine, University of Hawaii-Manoa, Honolulu, Hawaii 96816, USA. shikuma@hawaii.edu
authors.forename: Cecilia M
authors.initials: CM
authors.lastname: Shikuma
authors.forename: Victor G
authors.initials: VG
authors.lastname: Valcour
authors.forename: Silvia
authors.initials: S
authors.lastname: Ratto-Kim
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Williams
authors.forename: Scott
authors.initials: S
authors.lastname: Souza
authors.forename: Mariana
authors.initials: M
authors.lastname: Gerschenson
authors.forename: Larry
authors.initials: L
authors.lastname: Day
authors.forename: Jerome H
authors.initials: JH
authors.lastname: Kim
authors.forename: Bruce
authors.initials: B
authors.lastname: Shiramizu
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D000998:Antiviral Agents / Q000627:therapeutic use; D001835:Body Weight; D018791:CD4 Lymphocyte Count; D016022:Case-Control Studies; D004279:DNA, Viral; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000821:virology*; D019247:HIV Wasting Syndrome / Q000209:etiology* / Q000821:virology*; D006801:Humans; D008875:Middle Aged; D009000:Monocytes / Q000821:virology*; D012189:Retrospective Studies; D019562:Viral Load
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral