Finding schizophrenia genes.
Genetic epidemiological studies suggest that individual variation in susceptibility to schizophrenia is largely genetic, reflecting alleles of moderate to small effect in multiple genes. Molecular genetic studies have identified a number of potential regions of linkage and 2 associated chromosomal abnormalities, and accumulating evidence favors several positional candidate genes. These findings are grounds for optimism that insight into genetic factors associated with schizophrenia will help further our understanding of this disease and contribute to the development of new ways to treat it.
Kirov
George
G
Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom.
O'Donovan
Michael C
MC
Owen
Michael J
MJ
D002869:Chromosome Aberrations; D002874:Chromosome Mapping / Q000379:methods; D002877:Chromosomes, Human / Q000235:genetics*; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D017720:Molecular Epidemiology; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*