Troponin as a marker of myocardiac damage in drug-induced cardiotoxicity.
Cardiac troponins T and I (cTnT and cTnI) are becoming the serum biomarkers of choice for monitoring potential drug-induced myocardial injury in both clinical and preclinical studies. The utility of cardiac troponins has been mainly demonstrated following the administration of antineoplastic drugs and beta-sympathomimetics, although the routine use of these markers in the monitoring in patients who received anthracyclines therapy is far from settled. Unlike the previous markers, which suffered from numerous shortages, the main advantages of cardiac troponins are their high specificity and sensitivity, wide diagnostic window and the possibility to use commercially available assays in clinical settings as well as in a broad range of laboratory animals. Nevertheless, in spite of vigorous research in this area, a number of questions are still unanswered and these are discussed in this review. The main problems seem to be the lack of standardisation of variety of troponin immunoassays, the assessment of suitable cutoff for drug-induced cardiotoxicity and determination of critical diagnostic window related to the optimal timing of sample collection, which may be drug-dependent.
Adamcova
Michaela
M
Department of Physiology, Charles University in Prague, Faculty of Medicine, Simkova 870, 500 38, Hradec Králové, Czech Republic. adamcova@lfhk.cuni.cz
Sterba
Martin
M
Simunek
Tomas
T
Potacova
Anna
A
Popelova
Olga
O
Mazurova
Yvona
Y
Gersl
Vladimir
V
D004353:Drug Evaluation, Preclinical; D006321:Heart / Q000187:drug effects*; D006801:Humans; D007118:Immunoassay; D012016:Reference Values; D012680:Sensitivity and Specificity; D018675:Toxicity Tests; D019210:Troponin I / Q000032:analysis*; D020107:Troponin T / Q000032:analysis*
D019210:Troponin I; D020107:Troponin T