title: Lack of correlation between iron overload cardiac dysfunction and needle liver biopsy iron concentration.
abstract: In 58 patients with transfusion dependent anemia, we compared cardiac function, as assessed by gated pooled cardiac scan at rest and during exercise stress, with liver iron concentrations (LIC) as determined by adequate biopsy samples. There was no relationship between LIC and cardiac function and deaths occurred in patients with LIC levels below those that are usually associated with cardiac death. LIC should not be used as a surrogate to determine risk of cardiac complications but purely for management of the hepatic iron load. Other methods, particularly magnetic resonance imaging, should be used to assess cardiac iron overload.
authors.forename: Vasili
authors.initials: V
authors.lastname: Berdoukas
authors.forename: Carolyn
authors.initials: C
authors.lastname: Dakin
authors.forename: Anthony
authors.initials: A
authors.lastname: Freema
authors.forename: Ian
authors.initials: I
authors.lastname: Fraser
authors.forename: Athanassios
authors.initials: A
authors.lastname: Aessopos
authors.forename: Timothy
authors.initials: T
authors.lastname: Bohane
mesh_terms: D000293:Adolescent; D000328:Adult; D029503:Anemia, Diamond-Blackfan / Q000150:complications / Q000628:therapy; D000755:Anemia, Sickle Cell / Q000150:complications / Q000628:therapy; D015415:Biomarkers; D001707:Biopsy, Needle; D002648:Child; D005260:Female; D015637:Gated Blood-Pool Imaging; D006331:Heart Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D007501:Iron / Q000032:analysis*; D019190:Iron Overload / Q000150:complications* / Q000209:etiology / Q000473:pathology; D008099:Liver / Q000737:chemistry* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013789:Thalassemia / Q000150:complications / Q000628:therapy; D065227:Transfusion Reaction
chemical_list: D015415:Biomarkers; D007501:Iron