A case of hemolysis in ABO-unmatched liver transplantation: use of washed group O red blood cells and steroids.
Liver transplantation is the only curative therapy for patients with end-stage liver disease. The high success rate and the increasing demand for the transplantation sometimes calls for ABO-compatible but nonidentical blood group orthotopic liver transplantation (OLT), which affords the opportunity to the production of antibody to red blood cells. Hemolytic anemia usually occurs 1 to 2 weeks after transplantation. Although mild in most patients, it can be life-threatening. Until now, a few cases showing hemolytic anemia due to donor ABO antibody formation after ABO-nonidentical OLT have been reported. In the reported cases of hemolytic anemia, most ABO-nonidentical OLT cases were O-to-A, but few reports are available on this subject with O-to-B ABO-nonidentical OLT. Herein, we report the experience with hemolysis after ABO-nonidentical OLT in a group O donor into a group B recipient and the successful treatment with transfusion of washed group O red blood cells and 60 mg dose of prednisolone for 3 days.
Bae
Si Hyun
SH
Department of Internal Medicine, Kangnam St. Marys Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.
Jang
Jeong Won
JW
Kim
Min Soo
MS
Oh
Hyun Jong
HJ
Choi
Jong Young
JY
Han
Nam Ik
NI
Yoon
Seung Kew
SK
Han
Joon Yeol
JY
Oh
Eun Jee
EJ
Kim
Dong Gu
DG
D000017:ABO Blood-Group System; D000328:Adult; D000743:Anemia, Hemolytic / Q000209:etiology* / Q000628:therapy; D001787:Blood Group Incompatibility / Q000150:complications*; D017707:Erythrocyte Transfusion / Q000009:adverse effects; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage*
D000017:ABO Blood-Group System; D005938:Glucocorticoids; D011239:Prednisolone