title: DNA vaccines for biodefence.
abstract: The advantages associated with DNA vaccines include the speed with which they may be constructed and produced at large-scale, the ability to produce a broad spectrum of immune responses, and the ability for delivery using non-invasive means. In addition, DNA vaccines may be manipulated to express multiple antigens and may be tailored for the induction of appropriate immune responses. These advantages make DNA vaccination a promising approach for the development of vaccines for biodefence. In this review, the potential of DNA vaccines for biodefence is discussed.
authors.affiliation: Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury, SP4 0JQ, UK. hsgarmory@dstl.gov.uk
authors.forename: Helen S
authors.initials: HS
authors.lastname: Garmory
authors.forename: Stuart D
authors.initials: SD
authors.lastname: Perkins
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Phillpotts
authors.forename: Richard W
authors.initials: RW
authors.lastname: Titball
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000276:immunology / Q000517:prevention & control*; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology; D001694:Biological Warfare; D004337:Drug Carriers; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008081:Liposomes; D013678:Technology, Pharmaceutical / Q000639:trends*; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology / Q000517:prevention & control*
chemical_list: D001428:Bacterial Vaccines; D004337:Drug Carriers; D008081:Liposomes; D019444:Vaccines, DNA; D014765:Viral Vaccines