title: [Adjuvant chemotherapy for Dukes B2 and C colon cancer combining 5-fluorouracil and folinic acid with or without carboplatin. Feasibility and comparison between standard and chronomodulated deliveries].
abstract: Thirty-seven patients operated from a Dukes B2-C colon cancer were randomised to receive as adjuvant infusional chemotherapy, nine 5 FU and folinic acid courses with or without carboplatin, as standard (de Gramont; 2 days every 2 weeks) or chronomodulated administration (4 days every 2 weeks). The overall tolerance was judged excellent with less than 7% courses with dose-adaptations. The two carboplatin arms presented an enhanced haematological toxicity, while some more cutaneous toxicity was observed in the chronomodulated arm with the three drugs.
authors.affiliation: Département d'oncologie médicale, CHC-Clinique Saint-Joseph, rue de Hesbaye, 75,4000 Liège, Belgique. christian.focan@chc.be
authors.forename: C
authors.initials: C
authors.lastname: Focan
authors.forename: J
authors.initials: J
authors.lastname: Bury
authors.forename: G
authors.initials: G
authors.lastname: Matus
authors.forename: M P
authors.initials: MP
authors.lastname: Graas
authors.forename: F
authors.initials: F
authors.lastname: Kreutz
authors.forename: L
authors.initials: L
authors.lastname: Longree
authors.forename: N
authors.initials: N
authors.lastname: Moeneclaey
authors.forename: A
authors.initials: A
authors.lastname: David
authors.forename: D
authors.initials: D
authors.lastname: Focan-Henrard
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000627:therapeutic use* / Q000633:toxicity; D016190:Carboplatin / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D002909:Chronobiology Phenomena; D003110:Colonic Neoplasms / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged
chemical_list: D016190:Carboplatin; D002955:Leucovorin; D005472:Fluorouracil