PTX cruiser: driving autoimmunity via TLR4.
Although the cause of autoimmune diseases is unknown, it has long been speculated that an infectious agent might have a role in their initiation and progression. Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), has been used to study factors in disease pathogenesis. A recent study shows that pertussis toxin, which is used as an adjuvant in EAE, uses Toll-like receptor 4 signaling to mediate its disease-inducing effect.
Racke
Michael K
MK
Department of Neurology, University of Texas Southwestern Medical Center, , Dallas, TX 75390-9036, USA. Michael.Racke@utsouthwestern.edu
Hu
Wei
W
Lovett-Racke
Amy E
AE
D000818:Animals; D015551:Autoimmunity / Q000187:drug effects* / Q000276:immunology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology; D006801:Humans; D008562:Membrane Glycoproteins / Q000276:immunology / Q000378:metabolism*; D019007:P-Selectin / Q000378:metabolism; D037342:Pertussis Toxin / Q000494:pharmacology*; D011956:Receptors, Cell Surface / Q000276:immunology / Q000378:metabolism*; D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors
D008562:Membrane Glycoproteins; D019007:P-Selectin; D011956:Receptors, Cell Surface; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors; D037342:Pertussis Toxin