title: Selective inhibition of Trypanosoma cruzi GAPDH by "bi-substrate" analogues.
abstract: A new series of "bi-substrate" analogues have been synthesized as potential inhibitors of the glyceraldehyde-3-phosphate dehydrogenase and one lead compound has been identified that inhibits the enzyme from Trypanosoma cruzi with good affinity and very high (50-fold) specificity.
authors.affiliation: University Chemical Laboratory, University of Cambridge, Cambridge CB2 1EW, UK. sl324@cam.ac.uk
authors.forename: Sylvain
authors.initials: S
authors.lastname: Ladame
authors.forename: Régis
authors.initials: R
authors.lastname: Fauré
authors.forename: Colette
authors.initials: C
authors.lastname: Denier
authors.forename: Faouzi
authors.initials: F
authors.lastname: Lakhdar-Ghazal
authors.forename: Michèle
authors.initials: M
authors.lastname: Willson
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000037:antagonists & inhibitors*; D014349:Trypanosoma cruzi / Q000201:enzymology*
chemical_list: D004791:Enzyme Inhibitors; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases