[Significance of MMP2 and MMP9 expression in prostate cancer].
OBJECTIVE
To evaluate the significance of the expression of matrix metalloproteinases (MMPs) in prostate cancer (PCa) and its clinical association.


METHODS
Fifty one cases of PCa and 10 cases of BPH were studied by immunohistochemical method using monoclonal antibodies to MMP2 and MMP9.


RESULTS
There was significant correlation between MMP2 or MMP9 and pathological grade, Gleason score and PCa metastasis.


CONCLUSIONS
The expression of MMP2 and MMP9 may play an important role in the development and metastasis of PCa.
Zhang
Xiao-Yi
XY
Department of Urology, China PLA General Hospital, Beijing 100853, China. doctorzhxy@163.com
Hong
Bao-Fa
BF
Chen
Guang-Fu
GF
Lu
Ya-Li
YL
Zhong
Mei
M
D000368:Aged; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis*; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology
D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9