title: Microbial transformation of prednisone.
abstract: The microbial transformation of prednisone (17alpha,21-dihydroxy-pregna-1,4-diene-3,11,20-trione) (1) by Cunninghamella elegans afforded two metabolites, 17alpha,21-dihydroxy-5alpha-pregn-1-ene-3,11,20-trione (2) and 17alpha,20S,21-trihydroxy-5alpha-pregn-1-ene-3,11-dione (3), while the fermentation of 1 with Fusarium lini, Rhizopus stolonifer and Curvularia lunata afforded a metabolite 1,4-pregnadiene-17alpha,20S,21-triol-3,11-dione (4). Compound 3 was found to be a new metabolite. Their structures were elucidated on the basis of spectroscopic techniques. Compound 3 showed inhibitory activity against lipoxygenase enzyme.
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. hej@cyber.net.pk
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.forename: Zafar Ali
authors.initials: ZA
authors.lastname: Siddiqui
authors.forename: S Ghulam
authors.initials: SG
authors.lastname: Musharraf
authors.forename: Sarfraz A
authors.initials: SA
authors.lastname: Nawaz
authors.lastname: Atta-Ur-Rahman
mesh_terms: D001203:Ascomycota / Q000378:metabolism; D020093:Cunninghamella / Q000378:metabolism; D005285:Fermentation; D005658:Fungi / Q000378:metabolism*; D005670:Fusarium / Q000378:metabolism; D015394:Molecular Structure; D011241:Prednisone / Q000737:chemistry / Q000378:metabolism*; D012233:Rhizopus / Q000378:metabolism
chemical_list: D011241:Prednisone