title: Synthesis of new derivatives of 1-(2-aminoethyl)-4-phenyl-3-(pyridin-3-yl)-1,2,4-triazoline-5-thione.
abstract: The reaction of 4-phenyl-3-(pyridin-3-yl)-1 2,4-triazoline-5-thione with ethylene chlorohydrine is described. The obtained compound is converted into 1-(2-chloroethyl)-4-phenyl-3-(pyridin-3-yl)-1,2,4-triazoline-5-thione. Its reaction with amines gave the corresponding 1-(2-aminoethyl)-4-phenyl-3-(pyridin-3-yl)-1,2,4-triazoline-5-thione derivatives. Concerning the structure of the obtained derivatives, it can be expected that these compounds can reveal potential pharmacological action on the central nervous system.
authors.affiliation: Department of Organic Chemistry, Faculty of Pharmacy, Medical University, 6 Staszica Str., 20-081 Lublin, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Pitucha
authors.forename: Monika
authors.initials: M
authors.lastname: Wujec
authors.forename: Maria
authors.initials: M
authors.lastname: Dobosz
mesh_terms: D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D011725:Pyridines / Q000138:chemical synthesis*; D013055:Spectrophotometry, Infrared; D014230:Triazoles / Q000138:chemical synthesis*
chemical_list: D007202:Indicators and Reagents; D011725:Pyridines; D014230:Triazoles