title: A fabrication platform for electrically mediated optically active biofunctionalized sites in BioMEMS.
abstract: We report a new approach for microfluidic optical bioanalysis that is based on the electrically driven assembly of bio-components on a transparent sidewall and the optical detection of the assembled components using planar waveguides. This allows localized electrical signals for bio-assembly and optical signals for bio-detection that can easily be applied in MEMS systems. We demonstrate a BioMEMS design incorporating this scheme and its output signal when using fluorescent detection.
authors.affiliation: Department of Electrical and Computer Engineering, College Park, MD 20742, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Powers
authors.forename: Stephan T
authors.initials: ST
authors.lastname: Koev
authors.forename: Arne
authors.initials: A
authors.lastname: Schleunitz
authors.forename: Hyunmin
authors.initials: H
authors.lastname: Yi
authors.forename: Vildana
authors.initials: V
authors.lastname: Hodzic
authors.forename: William E
authors.initials: WE
authors.lastname: Bentley
authors.forename: Gregory F
authors.initials: GF
authors.lastname: Payne
authors.forename: Gary W
authors.initials: GW
authors.lastname: Rubloff
authors.forename: Reza
authors.initials: R
authors.lastname: Ghodssi
mesh_terms: D032701:Biomimetics / Q000295:instrumentation* / Q000379:methods; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D044085:Microfluidics / Q000295:instrumentation* / Q000379:methods; D008856:Microscopy, Fluorescence / Q000295:instrumentation* / Q000379:methods; D055095:Optics and Photonics; D012680:Sensitivity and Specificity