title: Lack of mutations of the human telomerase RNA gene (hTERC) in myelodysplastic syndrome.
abstract: Myelodysplastic syndrome (MDS), considered a pre-leukemic state, has recently been categorized as a subset of bone marrow failure syndromes. Unlike other subtypes of bone marrow failure syndromes, such as aplastic anemia or dyskeratosis congenita, little is known about genetic alterations of human telomerase in MDS, despite the fact that immune cells from patients with MDS frequently exhibit telomere attrition.
authors.forename: Kazuma
authors.initials: K
authors.lastname: Ohyashiki
authors.forename: Jerry W
authors.initials: JW
authors.lastname: Shay
authors.forename: Junko H
authors.initials: JH
authors.lastname: Ohyashiki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004252:DNA Mutational Analysis; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D012313:RNA / Q000235:genetics*; D017422:Sequence Analysis, DNA; D019098:Telomerase / Q000235:genetics*; D016615:Telomere / Q000648:ultrastructure
chemical_list: C422952:telomerase RNA; D012313:RNA; D019098:Telomerase