title: [Pathogenic links between Kikuchi's disease and lupus: a report of three new cases].
abstract: BACKGROUND
  Histiocytic necrotizing lymphadenitis or Kikuchi-Fujimoto's disease is a rare anatomoclinical entity whose etiology remains unknown. It is mainly reported in young adult female, presenting with cervical lymphadenopathies, fever and asthenia. The diagnosis is based on the histological examination of a lymph node biopsy. The disease course is usually uneventful, but sometimes Kikuchi-Fujimoto's disease can reveal or evolve into a cutaneous or a systemic lupus.
  
  
  METHODS
  We report three new cases of Kikuchi's disease: the first one mimicked a systemic lupus, the second one was associated with a lupus-like rash, and a the last one was a severe case with hemophagocytic syndrome and a primo-infection with Epstein-Barr virus revealing a systemic lupus erythematosus.
  
  
  CONCLUSIONS
  Clinical and biological follow-up of patients presenting with Kikuchi's disease is necessary to look for an association with a lupus. We discuss the pathogenic links between Kikuchi's disease and lupus.
authors.affiliation: Service de médecine interne et maladies infectieuses, hôpital Haut-Lévêque, avenue de Magellan, 33604 Pessac, France.
authors.forename: C
authors.initials: C
authors.lastname: Leyral
authors.forename: F
authors.initials: F
authors.lastname: Camou
authors.forename: C
authors.initials: C
authors.lastname: Perlemoine
authors.forename: O
authors.initials: O
authors.lastname: Caubet
authors.forename: J L
authors.initials: JL
authors.lastname: Pellegrin
authors.forename: J F
authors.initials: JF
authors.lastname: Viallard
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D020042:Histiocytic Necrotizing Lymphadenitis / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000473:pathology; D008297:Male