title: High circulating thyrotropin levels in obese women are reduced after body weight loss induced by caloric restriction.
abstract: BACKGROUND
  Previous clinical studies concerning the impact of body weight loss on single plasma TSH concentration measurements or the TSH response to TRH in obese humans have shown variable results.
  
  
  OBJECTIVE
  The objective of this study was to investigate the effect of weight loss induced by caloric restriction on diurnal TSH concentrations and secretion in obese humans.
  
  
  METHODS
  This was a clinical, prospective, crossover study.
  
  
  METHODS
  The study was conducted at the Clinical Research Center of Leiden University Medical Center.
  
  
  METHODS
  Eleven obese premenopausal women (body mass index, 33.3 +/- 0.7 kg/m2) were studied.
  
  
  METHODS
  The study intervention was weight loss (50% reduction overweight by caloric restriction).
  
  
  METHODS
  Twenty-four-hour plasma TSH concentrations (10-min intervals) and the 24-h TSH secretion rate, calculated by a waveform-independent deconvolution technique (Pulse), were determined.
  
  
  RESULTS
  The 24-h TSH secretion rate was significantly higher in obese women than in normal weight controls, and weight loss was accompanied by diminished TSH release (before weight loss, 43.4 +/- 6.4 mU/liter.24 h; after weight loss, 34.4 +/- 5.9 mU/liter.24 h; P = 0.02). Circulating free T3 levels decreased after weight loss from 4.3 +/- 0.19 to 3.8 +/- 0.14 pmol/liter (P = 0.04). Differences in 24-h TSH release correlated positively with the decline of circulating leptin (r2 = 0.62; P < 0.01).
  
  
  CONCLUSIONS
  Elevated TSH secretion in obese women is significantly reduced by diet-induced weight loss. Among various physiological cues, leptin may be involved in this phenomenon. The decreases in TSH and free T3 may blunt energy expenditure in response to long-term calorie restriction, thereby frustrating weight loss attempts of obese individuals.
authors.affiliation: Department of General Internal Medicine (C4-83), Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.
authors.forename: Petra
authors.initials: P
authors.lastname: Kok
authors.forename: Ferdinand
authors.initials: F
authors.lastname: Roelfsema
authors.forename: Janneke G
authors.initials: JG
authors.lastname: Langendonk
authors.forename: Marijke
authors.initials: M
authors.lastname: Frölich
authors.forename: Jacobus
authors.initials: J
authors.lastname: Burggraaf
authors.forename: A Edo
authors.initials: AE
authors.lastname: Meinders
authors.forename: Hanno
authors.initials: H
authors.lastname: Pijl
mesh_terms: D000328:Adult; D031204:Caloric Restriction; D002940:Circadian Rhythm; D018592:Cross-Over Studies; D004038:Diet, Reducing; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood; D009765:Obesity / Q000097:blood* / Q000178:diet therapy*; D011446:Prospective Studies; D013972:Thyrotropin / Q000097:blood*; D015431:Weight Loss
chemical_list: D020738:Leptin; D013972:Thyrotropin