title: Biological studies of azadirachtin and its derivatives against polyphagous pest, Spodoptera litura.
abstract: Azadirachtin-A (Aza-A, figure 1) was subjected to a variety of synthetic transformations and the antifeedant activity and toxicity of the azadirachtin derivatives were assessed against second instar larvae Spodoptera litura on castor leaves in comparison with the crude material containing 9.14% Aza-A, as well as relatively pure 91% Aza-A. A probable mechanism for the base initiated fragmentation of the diketocarbonate into a decalin fragment and a spiroketal moiety has been proposed. The present study indicates that the combination of insect toxicity and antifeedancy of azadirachtin provides good crop protection.
authors.affiliation: Department of Applied Chemistry, Faculty of Technology & Engineering, The Maharaja Sayajirao University of Baroda, Vadodara--390 001, India.
authors.forename: P T
authors.initials: PT
authors.lastname: Deota
authors.forename: P R
authors.initials: PR
authors.lastname: Upadhyay
mesh_terms: D000818:Animals; D005247:Feeding Behavior / Q000187:drug effects; D007306:Insecticides / Q000737:chemistry / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D036701:Limonins / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D018411:Spodoptera / Q000187:drug effects*
chemical_list: D007306:Insecticides; D036701:Limonins; C010329:azadirachtin