title: A review of DNA microarray analysis of human neuroblastomas.
abstract: Neuroblastoma (NBL) is an enigmatic tumor with heterogeneous clinical behaviors including maturation, regression, and aggressive growth. Despite recent progress in therapeutic strategies against advanced NBL, long-term outcomes still remain very poor. The prediction of cancer prognosis is one of the most urgent demands to initiate the suitable treatment of NBL. Recent papers have demonstrated that cancers can be diagnosed on the basis of gene expression profiling. We have been proceeded NBL cDNA project to collect a large number of genes expressed in NBLs, to identify the genes differentially expressed between favorable and unfavorable NBLs, and to make an NBL-proper cDNA chip for large-scale analysis of NBL tumors. Computational analysis of gene expression data in NBLs identified many prognosis-related genes and provided a classifier to predict the patient prognosis with high efficiency. Conversion of these findings into better diagnosis and treatment is now underway. Thus, molecular profiling of NBL has become a feasible tool for clinical applications.
authors.affiliation: Division of Biochemistry, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan.
authors.forename: Miki
authors.initials: M
authors.lastname: Ohira
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Oba
authors.forename: Yoko
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Takahiro
authors.initials: T
authors.lastname: Hirata
authors.forename: Shin
authors.initials: S
authors.lastname: Ishii
authors.forename: Akira
authors.initials: A
authors.lastname: Nakagawara
mesh_terms: D018076:DNA, Complementary; D005786:Gene Expression Regulation; D006801:Humans; D009447:Neuroblastoma / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D011379:Prognosis
chemical_list: D018076:DNA, Complementary