title: Preparation and characterization of a novel pH-sensitive ion exchange resin.
abstract: Methylacrylic acid/styrene cross-linked with divinylbenzene is a novel pH-sensitive ion exchange resin. Microspheres of this resin were characterized by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The microspheres showed a pulsatile swelling behavior when the pH of the media changed. The pH-sensitive microspheres were loaded with salbutamol sulfate and the drug-release characteristics were studied under both simulated gastric and intestinal pH conditions. The results obtained showed that the drug release also depended on the pH of the release media.
authors.affiliation: Department of Pharmaceutics, Shen yang Pharmaceutical University, Shen yang 110016, People's Republic of China. liuhongfei1979@sohu.com
authors.forename: Hongfei
authors.initials: H
authors.lastname: Liu
authors.forename: Shu
authors.initials: S
authors.lastname: Zhang
authors.forename: Shufang
authors.initials: S
authors.lastname: Nie
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.forename: Xiyang
authors.initials: X
authors.lastname: Sun
authors.forename: Xingang
authors.initials: X
authors.lastname: Yang
authors.forename: Weisan
authors.initials: W
authors.lastname: Pan
mesh_terms: D006863:Hydrogen-Ion Concentration; D007474:Ion Exchange; D007475:Ion Exchange Resins / Q000032:analysis* / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D010316:Particle Size
chemical_list: D007475:Ion Exchange Resins