The 5-year incidence and risk factors for age-related maculopathy in a general Japanese population: the Hisayama study.
OBJECTIVE
To estimate the 5-year incidence and risk factors for age-related maculopathy (ARM) in a representative older Japanese population.


METHODS
A population-based cohort study was conducted in 1998 on 1482 Hisayama residents aged 50 years or older, and 961 of these subjects attended the 5-year follow-up examinations in 2003. At both time points, the characteristics of ARM were determined by grading color fundus photographs according to the Wisconsin Age-Related Maculopathy Grading System. Using these cohort data, logistic regression analyses were performed to determine the risk factors for ARM. Nine possible risk factors were examined: age, sex, hypertension, diabetes, hyperlipidemia, smoking, alcohol intake, body mass index, and white blood cell count.


RESULTS
The 5-year incidence of early ARM was 8.5%, and that of late ARM was 0.8%. Men were found to have a significantly higher incidence of late ARM than did women. The incidence of both early and late ARM increased significantly with age. Multiple logistic regression analysis showed that age and smoking were significantly associated with early and late ARM.


CONCLUSIONS
The results suggest that the overall 5-year incidence of early ARM is 8.0% and that of late ARM is 0.8% in the general Japanese population and that higher age and smoking are relevant risk factors for early and late ARM in the Japanese.
Miyazaki
Miho
M
Departments of Ophthalmology, Kyushu University, Fukuoka, Japan. miho-m@info.med.kyushu-u.ac.jp
Kiyohara
Yutaka
Y
Yoshida
Ayako
A
Iida
Mitsuo
M
Nose
Yoshiaki
Y
Ishibashi
Tatsuro
T
D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006306:Health Surveys; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008268:Macular Degeneration / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D017678:Sex Distribution