Synthesis of substituted indole derivatives as a new class of antimalarial agents.
A series of substituted indole derivatives were synthesized and evaluated for their in vitro antimalarial activity against P. falciparum. Out of the 24 compounds synthesized six compounds have shown MIC of 1 microg/mL. These compounds are in vitro several folds more active than pyrimethamine.
Agarwal
Anu
A
Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India.
Srivastava
Kumkum
K
Puri
S K
SK
Chauhan
Prem M S
PM
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology*; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D011739:Pyrimethamine / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000962:Antimalarials; D007211:Indoles; D011739:Pyrimethamine