title: Antiproliferative activities of iron and platinum conjugates of salicylaldehyde semi-/thiosemicarbazones against C6 glioma cells.
abstract: The identification of novel therapeutic agents for the management of malignant gliomas represents an area of active research. Here, we show that among the iron and platinum complexes of 2-hydroxybenzaldehyde semi-/thiosemicarbazones the latter inhibits the growth of C6 glioma cells in vitro with an IC50 value of 45 microM. Structural characterization reveals iron complexes to be octahedral having intermediate S = 3/2 spin states while platinum complexes are found to be square planar moieties. Our findings suggest that the platinum compounds of 2-hydroxybenzaldehyde thiosemicarbazone are potential candidates for the treatment of malignant gliomas.
authors.affiliation: Department of Chemistry, University of Pune, Pune 411007, India.
authors.forename: J
authors.initials: J
authors.lastname: Patole
authors.forename: S
authors.initials: S
authors.lastname: Padhye
authors.forename: M S
authors.initials: MS
authors.lastname: Moodbidri
authors.forename: N
authors.initials: N
authors.lastname: Shirsat
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005910:Glioma / Q000473:pathology*; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure; D010984:Platinum / Q000737:chemistry*; D051381:Rats; D013882:Thiosemicarbazones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000447:Aldehydes; D013882:Thiosemicarbazones; C013243:salicylaldehyde; D010984:Platinum; D007501:Iron