Copper- and ligand-free Sonogashira reaction catalyzed by Pd(0) nanoparticles at ambient conditions under ultrasound irradiation.
The Sonogashira reaction proceeds at ambient temperature (30 degrees C) in acetone or room-temperature ionic liquid, 1,3-di-n-butylimidazolium tetrafluoroborate ([bbim]BF4), as solvent under ultrasound irradiation to give enhanced reaction rates, excellent chemoselectivity, and high yields in the absence of a copper cocatalyst and a phosphine ligand. TEM analysis showed the formation of stable, crystalline, and polydispersed Pd(0) nanoparticles as catalyst for the reaction.
Gholap
Atul R
AR
Organic Chemistry,Technology Division, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune-411 008, India.
Venkatesan
K
K
Pasricha
Renu
R
Daniel
Thomas
T
Lahoti
Rajgopal J
RJ
Srinivasan
Kumar V
KV