title: A case of hemolysis in ABO-unmatched liver transplantation: use of washed group O red blood cells and steroids.
abstract: Liver transplantation is the only curative therapy for patients with end-stage liver disease. The high success rate and the increasing demand for the transplantation sometimes calls for ABO-compatible but nonidentical blood group orthotopic liver transplantation (OLT), which affords the opportunity to the production of antibody to red blood cells. Hemolytic anemia usually occurs 1 to 2 weeks after transplantation. Although mild in most patients, it can be life-threatening. Until now, a few cases showing hemolytic anemia due to donor ABO antibody formation after ABO-nonidentical OLT have been reported. In the reported cases of hemolytic anemia, most ABO-nonidentical OLT cases were O-to-A, but few reports are available on this subject with O-to-B ABO-nonidentical OLT. Herein, we report the experience with hemolysis after ABO-nonidentical OLT in a group O donor into a group B recipient and the successful treatment with transfusion of washed group O red blood cells and 60 mg dose of prednisolone for 3 days.
authors.affiliation: Department of Internal Medicine, Kangnam St. Marys Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.
authors.forename: Si Hyun
authors.initials: SH
authors.lastname: Bae
authors.forename: Jeong Won
authors.initials: JW
authors.lastname: Jang
authors.forename: Min Soo
authors.initials: MS
authors.lastname: Kim
authors.forename: Hyun Jong
authors.initials: HJ
authors.lastname: Oh
authors.forename: Jong Young
authors.initials: JY
authors.lastname: Choi
authors.forename: Nam Ik
authors.initials: NI
authors.lastname: Han
authors.forename: Seung Kew
authors.initials: SK
authors.lastname: Yoon
authors.forename: Joon Yeol
authors.initials: JY
authors.lastname: Han
authors.forename: Eun Jee
authors.initials: EJ
authors.lastname: Oh
authors.forename: Dong Gu
authors.initials: DG
authors.lastname: Kim
mesh_terms: D000017:ABO Blood-Group System; D000328:Adult; D000743:Anemia, Hemolytic / Q000209:etiology* / Q000628:therapy; D001787:Blood Group Incompatibility / Q000150:complications*; D017707:Erythrocyte Transfusion / Q000009:adverse effects; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage*
chemical_list: D000017:ABO Blood-Group System; D005938:Glucocorticoids; D011239:Prednisolone