Immunotactoid glomerulopathy with microtubular deposits, with reference to the characteristics of Japanese cases.
We present the case of a 69-year-old man with nephrotic syndrome and renal insufficiency, who developed lobular glomerulonephritis. An electron microscopy examination of a renal biopsy showed microtubular structures of 24 nm in diameter in the subendothelial space and the paramesangial area. These deposits were PAS-positive and Congo red-negative, and revealed predominantly positive staining for kappa light chain. There was no evidence of diseases with highly organized glomerular deposits, such as amyloidosis, cryoglobulinemia, systemic lupus erythematosus or paraproteinemia. Therefore, the patient was diagnosed to have immunotactoid glomerulopathy (ITG). During a seven-year course he has not developed any disease known to be associated with organized glomerular immune deposits. Hence, we believe ITG occurred as a primary glomerular disease in this case. We also highlight cases of ITG with microtubular deposits that have been reported in Japan, compare these cases to previous reports, and show that the characteristics of the Japanese cases are male predominance; a high incidence of membranoproliferative glomerulonephritis (MPGN); a low incidence of monoclonal gammopathy and hematological malignancies and a higher incidence of hypocomplementemia.
Fukuda
M
M
Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Japan. m-fukuda@med.nagoya-cu.ac.jp
Morozumi
K
K
Oikawa
T
T
Motokawa
M
M
Usami
T
T
Yoshida
A
A
Kimura
G
G
D000368:Aged; D000527:Alprostadil / Q000627:therapeutic use; D001707:Biopsy, Needle; D001774:Blood Chemical Analysis; D001803:Blood Transfusion; D003131:Combined Modality Therapy; D004109:Dilazep / Q000627:therapeutic use; D005500:Follow-Up Studies; D015432:Glomerulonephritis, Membranoproliferative / Q000276:immunology* / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007150:Immunohistochemistry; D007564:Japan; D007677:Kidney Function Tests; D008297:Male; D008870:Microtubules / Q000648:ultrastructure*; D011507:Proteinuria / Q000175:diagnosis / Q000628:therapy; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome
D007074:Immunoglobulin G; D000527:Alprostadil; D004109:Dilazep