title: Acute renal failure after placement of tobramycin-impregnated bone cement in an infected total knee arthroplasty.
abstract: Tobramycin-impregnated bone cement is frequently used in revision procedures of infected total hip and knee arthroplasties. Aminoglycoside-impregnated cement is typically fashioned into beads or block spacers, which are temporarily placed in infected joint spaces. The use of aminoglycoside-impregnated bone cement has allowed the local concentration to exceed the minimum inhibitory concentration breakpoint of susceptible organisms while serum concentrations after 48 hours were usually not detected. Nephrotoxic complications are rarely encountered with this type of antibiotic delivery method. However, we report the case of an 85-year-old man with a history of renal insufficiency who experienced acute renal failure after undergoing revision treatment of an infected knee arthroplasty with the combined use of tobramycin-cefazolin bone cement and a block spacer. Clinicians should be aware of the potential for aminoglycoside-induced nephrotoxicity from the use of this combination.
authors.affiliation: Department of Pharmacy, Borgess Medical Center, Kalamazoo, Michigan, USA. Curtis@borgess.com
authors.forename: James M
authors.initials: JM
authors.lastname: Curtis
authors.forename: Vicki
authors.initials: V
authors.lastname: Sternhagen
authors.forename: Donald
authors.initials: D
authors.lastname: Batts
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D019645:Arthroplasty, Replacement, Knee; D001843:Bone Cements / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D006801:Humans; D008297:Male; D014031:Tobramycin / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood
chemical_list: D000900:Anti-Bacterial Agents; D001843:Bone Cements; D003404:Creatinine; D014031:Tobramycin