title: Effect of intermittent inhaled tobramycin on sputum cytokine profiles in cystic fibrosis.
abstract: OBJECTIVE
  The aim of this study was to evaluate the anti-inflammatory properties of intermittent inhaled tobramycin.
  
  
  METHODS
  To establish this, we initiated a prospective study to measure the concentration of the three pro-inflammatory cytokines IL-8, IL-6 and TNF-alpha in the sputum from 20 cystic fibrosis (CF) patients (15 teenagers and 5 young adults) during cycles and off cycles.
  
  
  RESULTS
  A significant decrease in IL-8 (P = 0.001) and a more moderate decrease in IL-6 (P = 0.046) and TNF-alpha (P = 0.052) levels were observed during cycles, even if no significant decrease in the number of leucocytes was observed.
  
  
  CONCLUSIONS
  These results associated with a decrease in the Pseudomonas aeruginosa population can contribute in part to the beneficial effect of intermittent inhaled tobramycin on pulmonary function.
authors.affiliation: EA 3925, Laboratoire de Bactériologie-Hygiène, Hôpital Calmette, Boulevard du Professeur J. Leclercq, Lille, France. mohusson@chru-lille.fr
authors.forename: M O
authors.initials: MO
authors.lastname: Husson
authors.forename: N
authors.initials: N
authors.lastname: Wizla-Derambure
authors.forename: D
authors.initials: D
authors.lastname: Turck
authors.forename: P
authors.initials: P
authors.lastname: Gosset
authors.forename: B
authors.initials: B
authors.lastname: Wallaert
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D003550:Cystic Fibrosis / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D016207:Cytokines / Q000032:analysis*; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis; D016209:Interleukin-8 / Q000032:analysis; D011446:Prospective Studies; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification; D013183:Sputum / Q000187:drug effects / Q000276:immunology*; D014031:Tobramycin / Q000008:administration & dosage*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D016207:Cytokines; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D014031:Tobramycin