title: Effects of anaesthetic agents in interference of naloxone-induced opiate-withdrawal are dose-dependent in opiate-dependent rats.
abstract: In opiate-dependent rats previous studies showed that anaesthetic agents, such as chloral hydrate, midazolam and ketamine interfere with naloxone-precipitated opiate withdrawal. Each anaesthetic induces a specific pattern of interference, indicating that the interference is agent-dependent. In order to further investigate these effects and highlight a potential pharmacological basis of opiate withdrawal interference through anaesthetic agents, we hypothesized that anaesthetic-mediated interference of opiate withdrawal is also dose-dependent. Three groups of rats were compared in an experimental procedure of rapid withdrawal induction by an antagonist under anaesthesia using sub-anaesthetic dosage of midazolam, ketamine or saline. We observed that sub-anaesthetic dosage of ketamine, or midazolam, interferes significantly with opiate withdrawal expression. This brings arguments in favour of a pharmacological basis underlying rapid antagonists induction in opiate dependent rats.
authors.affiliation: CHU Brugmann (Université Libre de Bruxelles), Institut de Psychiatrie, Clinique d'Alcoologie and Toxicomanies, Brussels, Belgium. manu.streel@chu-brugmann.be
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Streel
authors.forename: Bernard
authors.initials: B
authors.lastname: Dan
authors.forename: Valérie
authors.initials: V
authors.lastname: Antoniali
authors.forename: Béatrice
authors.initials: B
authors.lastname: Clement
authors.forename: Salvatore
authors.initials: S
authors.lastname: Campanella
authors.forename: Catherine
authors.initials: C
authors.lastname: Hanak
authors.forename: Philippe
authors.initials: P
authors.lastname: Vanderlinden
authors.forename: Isy
authors.initials: I
authors.lastname: Pelc
authors.forename: Paul
authors.initials: P
authors.lastname: Verbanck
mesh_terms: D000777:Anesthetics / Q000008:administration & dosage* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D009270:Naloxone / Q000633:toxicity*; D009293:Opioid-Related Disorders / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D000777:Anesthetics; D009270:Naloxone