Recognition of lipid antigens by T cells.
Recent studies have shown that the recognition of lipid antigens by the immune system is important for defence against infection and other diseases, and that lipid-specific responses occur at higher frequencies than previously suspected. Thanks to several recent advances in this field, we now have a better appreciation of the molecular and cellular requirements of T-cell stimulation by lipids. These findings have raised new questions about the mechanisms of lipid presentation, the priming and clonal expansion of lipid-specific T cells, and their differentiation into memory cells. A greater understanding of lipid-specific T cells and the molecular mechanisms of lipid immunogenicity should facilitate the development of lipid-based vaccines.
De Libero
Gennaro
G
Experimental Immunology, Department of Research, University Hospital, Basel 4031, Switzerland. gennaro.delibero@unibas.ch
Mori
Lucia
L
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000378:metabolism; D000942:Antigens, Bacterial / Q000737:chemistry / Q000276:immunology*; D018949:Antigens, CD1 / Q000276:immunology* / Q000378:metabolism; D001324:Autoantigens / Q000737:chemistry / Q000276:immunology*; D015551:Autoimmunity / Q000276:immunology; D001692:Biological Transport; D006801:Humans; D007156:Immunologic Memory; D050356:Lipid Metabolism; D008055:Lipids / Q000737:chemistry / Q000276:immunology*; D038041:Lymphopoiesis; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
D000942:Antigens, Bacterial; D018949:Antigens, CD1; D001324:Autoantigens; D008055:Lipids