The sequelae of cranial irradiation on human cognition.
Cranial irradiation (CI) confers remediation of many CNS anomalies. CI, however, carries risks to cognitive performance. A wealth of data describes such deficits specifically in humans. Risk factors that promote increased susceptibility to cognitive decline have also been identified. This paper discusses and grades these risk factors, including age, gender, and the inclusion of chemotherapy, that increase the likelihood of pathologic cognitive development in the human population.
Sarkissian
Vahé
V
Department of Neurological Surgery, University of California at San Francisco, 513 Parnassus Ave., San Francisco, CA 94143, USA. vsar2525@itsa.ucsf.edu
D000375:Aging / Q000502:physiology; D001921:Brain / Q000528:radiation effects*; D003071:Cognition / Q000528:radiation effects*; D003072:Cognition Disorders / Q000453:epidemiology / Q000209:etiology* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D011878:Radiotherapy / Q000009:adverse effects; D012307:Risk Factors; D012727:Sex Characteristics