Cytotoxic arylnaphthalene lignans from a Vietnamese acanthaceae, Justicia patentiflora.
One new norlignan (1) and five new lignans (2-6) were isolated from the leaves and stems of Justicia patentiflora by a bioassay-guided purification. Five known compounds, carinatone, diphyllin, justicidin A, taiwanin E, and tuberculatin, were also found in J. patentiflora. Most of the new compounds display significant activity in in vitro cytotoxic assays against KB, HCT116, and MCF-7 cancer cell lines and arrest the cell cycle in the G0/G1 phase.
Susplugas
Sophie
S
Institut de Chimie des Substances Naturelles, CNRS, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
Hung
Nguyen Van
NV
Bignon
Jérôme
J
Thoison
Odile
O
Kruczynski
Anna
A
Sévenet
Thierry
T
Guéritte
Françoise
F
D027901:Acanthaceae / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D016193:G1 Phase / Q000187:drug effects; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D016192:Resting Phase, Cell Cycle / Q000187:drug effects; D014407:Tumor Cells, Cultured; D014744:Vietnam
D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; C501783:justicinol; C501782:justiflorinol; C501784:patentiflorin A