Surface-functionalized nanoparticles for controlled drug delivery.
Nanoparticles have been extensively investigated in drug-delivery systems. Especially, the effectiveness of the surface-functionalized nanoparticles, which consist of copolymers with functional molecules, is well demonstrated. This chapter describes the complete technique for the preparation of surface-functionalized nanoparticles. Tetracycline with an affinity to bone was chosen as a model material for surface functionalization. There are two steps for the preparation of tetracycline-modified nanoparticles. The first step is the conjugation of poly(D,L-lactide-co- glycolic acid) with tetracycline via carbodiimide chemistry and is the most often employed. Three kinds of techniques--the emulsification-diffusion method, nanoprecipitation, and the dialysis method are used for nanoparticle formation of the resulting copolymer. Prepared nanoparticles having a size <200 nm and a hydrophilic surface layer can be applied for bone-specific drug delivery.
Choi
Sung-Wook
SW
Division of Chemical Engineering and Biotechnology, Yonsei University, Seoul, Korea.
Kim
Woo-Sik
WS
Kim
Jung-Hyun
JH
D000818:Animals; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D008832:Microchemistry / Q000379:methods; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D013752:Tetracycline / Q000737:chemistry*
D004337:Drug Carriers; D013752:Tetracycline