Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease.
Analysis of the apolipoprotein E genotype in sibpairs with Parkinson's disease showed the E4 allele was over represented in those who shared the adjacent chromosome 19 markers. This suggests that apolipoprotein E4 is responsible for the linkage peak in this region and that it is a modest risk factor for Parkinson's disease.
Martinez
Maria
M
INSERM EMI00-06, Evry, France.
Brice
Alexis
A
Vaughan
Jenny R
JR
Zimprich
Alexander
A
Breteler
Monique M B
MM
Meco
Giuseppe
G
Filla
Alessandro
A
Farrer
Matthew J
MJ
Bétard
Christine
C
Singleton
Andrew
A
Hardy
John
J
De Michele
Giuseppe
G
Bonifati
Vincenzo
V
Oostra
Ben A
BA
Gasser
Thomas
T
Wood
Nick W
NW
Dürr
Alexandra
A
D000483:Alleles; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D005192:Family Health; D005787:Gene Frequency; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008126:Lod Score; D018895:Microsatellite Repeats; D010300:Parkinson Disease / Q000235:genetics*; D035781:Siblings
D053327:Apolipoprotein E4; D001057:Apolipoproteins E