[The effect of esmolol on hemodynamic of the myocardial bridging-mural mural coronary artery].
OBJECTIVE
To assess the effect of beta blocker on blood flow velocity and reserve on the intramural coronary artery of patients with myocardial bridging.


METHODS
In 8 patients with myocardial bridge, intracoronary Doppler was performed before and after esmolol was given intravenously. The basic average peak velocity (bAPV), hyperaemic average peak velocity (hAPV) of blood flow, and coronary flow reserve (CFR) proximal and distal to the mural myocardial bridging was measured and compared.


RESULTS
After esmolol injection, the mural coronary diameter systolic reduction decreased from (58.0 +/- 14.7)% to (26.0 +/- 9.8)% (P < 0.01); the bAPV proximal and distal to myocardial bridging separately decreased from (19.4 +/- 4.9) cm/s and (18.4 +/- 3.6) cm/s to (4.7 +/- 3.9) cm/s (P < 0.01) and (15.1 +/- 1.5) cm/s (P < 0.05). Under hyperemization, esmolol changed the hAPV of proximal and distal to myocardial bridging separately from (54.1 +/- 14.9) cm/s and (44.7 +/- 9.4) cm/s to (49.7 +/- 16.4) cm/s and (48.9 +/- 10.1) cm/s (all P > 0.05); thus, the value of CFR both proximal and distal to myocardial bridge increased separately from 2.8 +/- 0.3 and 2.5 +/- 0.5 to 3.4 +/- 0.5 and 3.2 +/- 0.6 (all P < 0.01).


CONCLUSIONS
Esmolol can decreased the compression of the intramural coronary artery and increased the CFR to normal level of it.
Zhang
Guo-Hui
GH
The First People's Hospital, Zhenjiang 212002, China.
Ge
Jun-Bo
JB
Qian
Ju-Ying
JY
Fan
Bing
B
Wang
Qi-Bing
QB
Lu
Yan
Y
Wang
Hao
H
Feng
Qi
Q
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D003326:Coronary Circulation / Q000187:drug effects / Q000502:physiology*; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D054084:Myocardial Bridging / Q000188:drug therapy / Q000503:physiopathology* / Q000648:ultrastructure; D011412:Propanolamines / Q000494:pharmacology* / Q000627:therapeutic use; D018084:Ultrasonography, Interventional
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; C036604:esmolol