Histidine residue at position 234 of oxidosqualene-lanosterol cyclase from saccharomyces cerevisiae simultaneously influences cyclization, rearrangement, and deprotonation reactions.
Wu
Tung-Kung
TK
Department of Biological Science and Technology, Center for Interdisciplinary Molecular Science, National Chiao Tung University, 300 Hsin-Chu, Taiwan, Republic of China. tkwmll@mail.nctu.edu.tw
Liu
Yuan-Ting
YT
Chang
Cheng-Hsian
CH
D000595:Amino Acid Sequence; D003500:Cyclization; D006639:Histidine / Q000737:chemistry* / Q000378:metabolism*; D019751:Intramolecular Transferases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D008958:Models, Molecular; D016297:Mutagenesis, Site-Directed; D016133:Polymerase Chain Reaction; D012441:Saccharomyces cerevisiae / Q000201:enzymology*; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D014315:Triterpenes / Q000737:chemistry
D029701:Saccharomyces cerevisiae Proteins; D014315:Triterpenes; D006639:Histidine; D019751:Intramolecular Transferases; C021924:lanosterol synthase