Genetic aspects of atrial fibrillation.
Atrial fibrillation (AF) occurs predominantly in the elderly and is commonly associated with underlying cardiac diseases. A significant number of patients, however, have early onset AF that is not associated with any underlying disease. At present, it is unknown how often this form of AF is familial and how frequently familial AF is due to genetic causes. Recent data suggest that familial AF occurs more frequently than previously recognized. Also, in AF in the setting of underlying diseases, it is suggested that some form of genetic control may be present. Understanding the molecular mechanisms underlying AF may provide insight into the pathogenesis of AF and eventually may lead to improved, patient-tailored rhythm control strategies.
Wiesfeld
Ans C P
AC
Thoraxcenter, Department of Cardiology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.
Hemels
Martin E W
ME
Van Tintelen
J Peter
JP
Van den Berg
Maarten P
MP
Van Veldhuisen
Dirk J
DJ
Van Gelder
Isabelle C
IC
D000368:Aged; D000804:Angiotensin II / Q000235:genetics; D001281:Atrial Fibrillation / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D017630:Connexins / Q000235:genetics; D003327:Coronary Disease / Q000150:complications / Q000378:metabolism; D006329:Heart Conduction System / Q000503:physiopathology; D006333:Heart Failure / Q000150:complications / Q000378:metabolism; D006801:Humans; D011110:Polymorphism, Genetic; D000097003:Gap Junction alpha-5 Protein
D000804:Angiotensin II; D017630:Connexins; D000097003:Gap Junction alpha-5 Protein