[Perspectives on neuroprotection. Could acid-sensing ion channels be a target of new treatments?].
Recent studies on neuroprotection in ischemia have demonstrated that the activation of neuronal acid-sensing ion channels type 1 (ASIC-1) can lead to neuronal death. Ongoing studies on this subject show that ASIC-1 may be a new target for therapy of ischemic ictus.
Rossi
Giuliano
G
Primario Medico f.r., Ospedale San Filippo Neri, Roma.
D062565:Acid Sensing Ion Channels; D002545:Brain Ischemia / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D008565:Membrane Proteins / Q000187:drug effects* / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000187:drug effects* / Q000502:physiology; D015222:Sodium Channels / Q000187:drug effects* / Q000502:physiology
C568266:ASIC1 protein, human; D062565:Acid Sensing Ion Channels; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D015222:Sodium Channels