GDIs: central regulatory molecules in Rho GTPase activation.
The GDP dissociation inhibitors (GDIs) are pivotal regulators of Rho GTPase function. GDIs control the access of Rho GTPases to regulatory guanine nucleotide exchange factors and GTPase-activating proteins, to effector targets and to membranes where such effectors reside. We discuss here our current understanding of how Rho GTPase-GDI complexes are regulated by various proteins, lipids and enzymes that exert GDI displacement activity. We propose that phosphorylation mediated by diverse kinases might provide a means of controlling and coordinating Rho GTPase activation.
DerMardirossian
Céline
C
Departments of Immunology and Cell Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.
Bokoch
Gary M
GM
D000818:Animals; D020536:Enzyme Activators / Q000494:pharmacology; D020730:Guanine Nucleotide Dissociation Inhibitors / Q000378:metabolism* / Q000502:physiology*; D020662:Guanine Nucleotide Exchange Factors / Q000494:pharmacology; D006801:Humans; D008055:Lipids / Q000494:pharmacology; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism*; D011506:Proteins / Q000502:physiology; D025521:Tumor Suppressor Proteins; D020691:rab GTP-Binding Proteins / Q000378:metabolism*; D020741:rho GTP-Binding Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D062950:rho Guanine Nucleotide Dissociation Inhibitor gamma; D062947:rho-Specific Guanine Nucleotide Dissociation Inhibitors
C569643:ARHGDIG protein, human; D020536:Enzyme Activators; C086796:GDP dissociation inhibitor 1; D020730:Guanine Nucleotide Dissociation Inhibitors; D020662:Guanine Nucleotide Exchange Factors; D008055:Lipids; D011506:Proteins; D025521:Tumor Suppressor Proteins; D062950:rho Guanine Nucleotide Dissociation Inhibitor gamma; D062947:rho-Specific Guanine Nucleotide Dissociation Inhibitors; D011494:Protein Kinases; D020691:rab GTP-Binding Proteins; D020741:rho GTP-Binding Proteins