Macrophage migration inhibitory factor reduces the growth of virulent Mycobacterium tuberculosis in human macrophages.
Macrophage migration inhibitory factor (MIF) is a key mediator of the innate immune system and plays a crucial role in the host response to bacterial infections. Its role in immunity to intracellular pathogens has not been well studied. Here, we show that MIF released by infected human macrophages inhibits the growth of virulent Mycobacterium tuberculosis.
Oddo
Mauro
M
Medical Critical Care Division, University Hospital, CH-1011 Lausanne, Switzerland. mauro.oddo@chuv.hospvd.ch
Calandra
Thierry
T
Bucala
Richard
R
Meylan
Pascal R A
PR
D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors / Q000502:physiology*; D008264:Macrophages / Q000276:immunology* / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000254:growth & development / Q000276:immunology*; D014774:Virulence
D008263:Macrophage Migration-Inhibitory Factors