Sesquiterpenoids from Saussurea laniceps.
Two new guaiane-type sesquiterpenoids (1 and 2) and one new eudesmane-type sesquiterpenoid (3) were isolated from Saussurea laniceps. The structures of these compounds were established by spectroscopic methods, and the absolute stereochemistry of compounds 1 and 2 was determined by Mosher's method. The immunomodulatory activities of compounds 1-3 were evaluated. Of these, compound 3 showed significant inhibition of the proliferation of murine T and B cells in vitro.
Wang
Hong-Bing
HB
Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
Zhang
Hua-Ping
HP
Zhou
Yu
Y
Zuo
Jian-Ping
JP
Qin
Guo-Wei
GW
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007155:Immunologic Factors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D030441:Saussurea / Q000737:chemistry*; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects
C501786:3alpha,7alpha-12-trihydroxyeudesm-4(15)-11(13)-diene; C501787:3alpha,8alpha-dihydroxy-1alphaH,5alphaH,6betaH,7alphaH, 11betaH-guai-4(15),10(14)-dien-6,12-olide 8-O-(2-hydroxy)acrylate; C501785:3alpha,8alpha-dihydroxy-1alphaH,5alphaH,6betaH,7alphaH,11betaH-guai-4(15),10(14)-dien-6,12-olide 8-O-2-hydroxymethylacrylate; D004365:Drugs, Chinese Herbal; D007155:Immunologic Factors; D045787:Sesquiterpenes, Eudesmane; D045789:Sesquiterpenes, Guaiane