title: Rhythmic and dysrhythmic thalamocortical dynamics: GABA systems and the edge effect.
abstract: Brain function is fundamentally related in the most general sense to the richness of thalamocortical interconnectivity, and in particular to the rhythmic oscillatory properties of thalamocortical loops. Such rhythmicity is involved in the genesis of cognition, in the sleep-wake cycle, and in several neurological and psychiatric disorders. The role of GABA-mediated transmission in regulating these functional states is addressed here. At the cortical level, inhibition determines the spread of cortical activation by sculpting the precise activity patterns that underlie the details of cognition and motor control. At the thalamic level, GABA-mediated inhibition modulates and resets distribution of the ongoing thalamocortical rhythmic oscillations that bind multisensory inputs into a single cognitive experience and regulate arousal levels.
authors.affiliation: Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA. llinar01@popmail.med.nyu.edu
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Llinás
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Urbano
authors.forename: Elena
authors.initials: E
authors.lastname: Leznik
authors.forename: Rey R
authors.initials: RR
authors.lastname: Ramírez
authors.forename: Hein J F
authors.initials: HJ
authors.lastname: van Marle
mesh_terms: D000818:Animals; D001931:Brain Mapping; D003071:Cognition / Q000502:physiology; D003344:Cortical Synchronization / Q000379:methods; D003952:Diagnostic Imaging / Q000379:methods; D004558:Electric Stimulation / Q000379:methods; D006801:Humans; D007395:Interneurons / Q000502:physiology; D015225:Magnetoencephalography / Q000379:methods; D009433:Neural Inhibition / Q000502:physiology; D016571:Neural Networks, Computer; D009434:Neural Pathways / Q000502:physiology*; D010507:Periodicity; D009435:Synaptic Transmission / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
chemical_list: D005680:gamma-Aminobutyric Acid