title: Effect of age and repeated hyperbaric oxygen treatments on vagal tone.
abstract: OBJECTIVE
  To evaluate the influence of repeated hyperbaric oxygen (HBO2) exposures and age on vagal response to hyperbaric oxygenation, and to evaluate the timing of changes in vagal activity during the treatments.
  
  
  METHODS
  Open, controlled, non-randomized study.
  
  
  METHODS
  Heart rate variability of 23 patients with chronic osteomyelitis or radionecrosis of the jaw or reconstructive surgery of the facial region was studied during repeated treatments. During each treatment, the patients were exposed to HBO2 at 2.5 ATA and heart rate variability was measured using power spectral analysis before compression, three times at 2.5 ATA and during and after decompression. The patients were grouped according to age (Cut-off point 50 years). Statistical analysis was carried out using analysis of variance for repeated measurements.
  
  
  RESULTS
  Repeated exposures did not change vagal response to hyperbaric oxygenation. Vagal activity measured by HF power increased significantly in both age groups during the HBO2 exposures but there were no significant difference between the groups in the response. However, the level of HF power was significantly higher in the subjects under 50 years old. Significant differences between consecutive measurements were related to pressure changes.
  
  
  CONCLUSIONS
  Repeated therapeutic HBO2exposures are not causing permanent changes in vagal control of the heart. Vagal responsiveness to hyperbaric hyperoxia is preserved in advanced age.
authors.affiliation: Dept. of Anesthesiology and Intensive Care, Turku University Hospital, Finland.
authors.forename: V E
authors.initials: VE
authors.lastname: Lund
authors.forename: E
authors.initials: E
authors.lastname: Kentala
authors.forename: H
authors.initials: H
authors.lastname: Scheinin
authors.forename: K
authors.initials: K
authors.lastname: Lertola
authors.forename: J
authors.initials: J
authors.lastname: Klossner
authors.forename: K
authors.initials: K
authors.lastname: Aitasalo
authors.forename: K
authors.initials: K
authors.lastname: Sariola-Heinonen
authors.forename: J
authors.initials: J
authors.lastname: Jalonen
mesh_terms: D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D006931:Hyperbaric Oxygenation; D007568:Jaw / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000503:physiopathology / Q000628:therapy*; D010025:Osteoradionecrosis / Q000503:physiopathology / Q000628:therapy*; D014630:Vagus Nerve / Q000502:physiology*