title: Cyclic peroxides derived from the marine sponge Plakortis simplex.
abstract: Two new cyclic peroxides, 2 and 3, were isolated from a sample of the Norwegian sponge Plakortis simplex. Their structures including relative stereochemistry were elucidated by interpretation of MS and NMR data. Compound 3 exhibited moderate in vitro activity against six solid human tumor cell lines with IC50 values in the range 7-15 microg/mL.
authors.affiliation: Institut für Biogeochemie und Meereschemie, Universität Hamburg, Bundesstrasse 55, D-20146 Hamburg, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Holzwarth
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Trendel
authors.forename: Pierre
authors.initials: P
authors.lastname: Albrecht
authors.forename: Armin
authors.initials: A
authors.lastname: Maier
authors.forename: Walter
authors.initials: W
authors.lastname: Michaelis
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003500:Cyclization; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009664:Norway; D010545:Peroxides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D010545:Peroxides