title: Solid-phase synthesis of hydrogen-bond surrogate-derived alpha-helices.
abstract: [reaction: see text] This report describes the solid-phase synthesis of hydrogen-bond surrogate-derived artificial alpha-helices by a ring-closing metathesis reaction. From a series of metathesis catalysts evaluated for the synthesis of these helices, the Hoveyda-Grubbs catalyst was found to afford high yields of the macrocycle irrespective of the peptide sequence.
authors.affiliation: Department of Chemistry, New York University, 100 Washington Square East, New York, New York 10003, USA.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Dimartino
authors.forename: Deyun
authors.initials: D
authors.lastname: Wang
authors.forename: Ross N
authors.initials: RN
authors.lastname: Chapman
authors.forename: Paramjit S
authors.initials: PS
authors.lastname: Arora
mesh_terms: D002384:Catalysis; D003500:Cyclization; D006860:Hydrogen Bonding; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*; D017433:Protein Structure, Secondary
chemical_list: D010455:Peptides