title: Therapeutic capacity of the synthetic peptide-based vaccine against Taenia solium cysticercosis in pigs.
abstract: The S3Pvac synthetic vaccine composed of three peptides (GK1, KETc1 and KETc12) effectively protect against pig cysticercosis. Preliminary results point to an additional cysticidal capacity induced by S3Pvac or GK1 immunization. Herein, clear evidences of the cysticidal effect of S3Pvac but not of GK1 are presented. S3Pvac immunization of already experimentally infected pigs induced a reduction in the parasite load, in the vesicular cysticerci and in their viability. It also substantially increases the percent of histological damaged cysticerci more importantly in muscles than in brains, with a concomitant reduction in the antibody levels. Thus, S3Pvac represents a powerful means of controlling cysticercosis infection in pigs.
authors.affiliation: Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, 04510 México, DF, México. aline@servidor.unam.mx
authors.forename: Aline S
authors.initials: AS
authors.lastname: de Aluja
authors.forename: Nelly M
authors.initials: NM
authors.lastname: Villalobos
authors.forename: Gabriela
authors.initials: G
authors.lastname: Nava
authors.forename: Andrea
authors.initials: A
authors.lastname: Toledo
authors.forename: José Juan
authors.initials: JJ
authors.lastname: Martínez
authors.forename: Agustín
authors.initials: A
authors.lastname: Plancarte
authors.forename: Luis Felipe
authors.initials: LF
authors.lastname: Rodarte
authors.forename: Gladis
authors.initials: G
authors.lastname: Fragoso
authors.forename: Edda
authors.initials: E
authors.lastname: Sciutto
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D006224:Cricetinae; D003551:Cysticercosis / Q000473:pathology / Q000517:prevention & control / Q000662:veterinary*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008297:Male; D009132:Muscles / Q000469:parasitology; D013552:Swine; D013553:Swine Diseases / Q000517:prevention & control*; D041201:Taenia solium / Q000276:immunology*; D022223:Vaccines, Subunit / Q000008:administration & dosage / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000909:Antibodies, Helminth; D022223:Vaccines, Subunit; D014614:Vaccines, Synthetic