Nitric oxide (NO) production inhibitory constituents of Tabebuia avellanedae from Brazil.
From the water extract of Brazilian Tabebuia avellanedae, two new iridoids (1, 2) and a new phenylethanoid glycoside (3) have been isolated together with twelve known compounds (4-15). Their structures were determined based on the spectroscopic data. The isolated compounds inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. Compounds 1, 3, 10, 11, and 12 showed inhibitory activities more potent (IC50, 13.8-26.1 microg/ml) than a positive control N(G)-monomethyl-L-arginine (L-NMMA; IC50, 27.4 microg/ml).
Awale
Suresh
S
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.
Kawakami
Tsukasa
T
Tezuka
Yasuhiro
Y
Ueda
Jun-Ya
JY
Tanaka
Ken
K
Kadota
Shigetoshi
S
D001938:Brazil; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D029663:Tabebuia
D010936:Plant Extracts; D009569:Nitric Oxide