title: Synthesis, crystal structure and biological activity of aryl [(N,N'-diacyl-N'-tert-butylhydrazino)thio]methylcarbamates.
abstract: A series of novel aryl [(N,N'-diacyl-N'-tert-butylhydrazino)thio]methylcarbamates were synthesized by the reaction of aryl (chlorothio)methylcarbamates with N,N'-diacyl-N-tert-butylhydrazines in the presence of sodium hydride. X-Ray single crystal diffraction of 2-isobutylphenyl [(N,N'-dibenzoyl-N'-tert-butylhydrazino)thio]methylcarbamate demonstrated the presence of N-S-N bonding. All of the compounds exhibited excellent larvicidal activities. Toxicity assays indicated that the products had knockdown activities of aryl methylcarbamates at higher concentrations and insect growth regulator activities of diacylhydrazines at lower concentrations.
authors.affiliation: State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Shang
authors.forename: Qing Min
authors.initials: QM
authors.lastname: Wang
authors.forename: Run Qiu
authors.initials: RQ
authors.lastname: Huang
authors.forename: Chun Hui
authors.initials: CH
authors.lastname: Mao
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: Fu Chun
authors.initials: FC
authors.lastname: Bi
authors.forename: Hai Bin
authors.initials: HB
authors.lastname: Song
mesh_terms: D000818:Animals; D002219:Carbamates / Q000737:chemistry* / Q000494:pharmacology*; D007306:Insecticides / Q000737:chemistry* / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D008958:Models, Molecular; D015394:Molecular Structure; D009036:Moths / Q000187:drug effects
chemical_list: D002219:Carbamates; D007306:Insecticides