title: Familial massive leiomyoma with esophageal leiomyomatosis: an unusual presentation in a father and his 2 daughters.
abstract: Esophageal leiomyomatosis and leiomyoma are benign neoplastic lesions composed of proliferating smooth muscle cells. Although rare, these 2 conditions may occur simultaneously in an individual patient. Symptomatic patients often require surgical management. We describe the first reported cases of family members presenting with esophageal leiomyomatosis and concomitant massive esophageal leiomyoma.
authors.affiliation: Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
authors.forename: Lawrence S
authors.initials: LS
authors.lastname: Lee
authors.forename: Michael
authors.initials: M
authors.lastname: Nance
authors.forename: Larry R
authors.initials: LR
authors.lastname: Kaiser
authors.forename: John C
authors.initials: JC
authors.lastname: Kucharczuk
mesh_terms: D000293:Adolescent; D000328:Adult; D000382:Agricultural Workers' Diseases; D000714:Anastomosis, Surgical; D002648:Child; D004938:Esophageal Neoplasms / Q000150:complications / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D016629:Esophagectomy; D017809:Fatal Outcome; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006548:Hernia, Diaphragmatic / Q000209:etiology / Q000601:surgery; D006801:Humans; D033162:Incidental Findings; D007813:Laparotomy; D007889:Leiomyoma / Q000150:complications / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D018231:Leiomyomatosis / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D008297:Male; D008800:Mexico / Q000208:ethnology; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D009394:Nephritis, Hereditary / Q000235:genetics; D010414:Pennsylvania; D011183:Postoperative Complications / Q000601:surgery