title: Local tumor control after 106Ru brachytherapy of choroidal melanoma.
abstract: OBJECTIVE
  To report on local tumor control after (106)Ru brachytherapy for choroidal melanoma.
  
  
  METHODS
  A total of 458 patients with choroidal melanoma were treated at a single institution between January 1993 and December 2001. The tumors had a median longest basal dimension of 10.6 mm and a median height of 3.2 mm. The brachytherapy was administered using a 15- or 20-mm plaque. For posterior tumors, the plaque was positioned eccentrically with its posterior edge aligned with the posterior tumor margin to reduce the radiation dose to the optic disk and fovea. A minimal scleral dose sufficient to cause visible choroidal atrophy provided a permanent ophthalmoscopic record of the distribution of choroidal irradiation. If radiotherapy to the posterior tumor was uncertain, adjunctive transpupillary thermotherapy was administered 6 months postoperatively.
  
  
  RESULTS
  The actuarial rates of tumor recurrence were 1%, 2%, and 3% at 2, 5, and 7 years, respectively. Local tumor recurrence correlated with the longest basal tumor dimension (Cox univariate analysis, p = 0.02, risk ratio 1.41, 95% confidence interval 1.06-1.88). Seven of the nine eyes with recurrent tumor were salvaged with additional conservative therapy.
  
  
  CONCLUSIONS
  The low rate of local tumor recurrence suggests that ruthenium plaque radiotherapy is effective with good case selection and if special measures are taken to ensure that the plaque is positioned correctly.
authors.affiliation: Ocular Oncology Service, St. Paul's Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool, United Kingdom. Bertil@damato.co.uk
authors.forename: Bertil
authors.initials: B
authors.lastname: Damato
authors.forename: Imran
authors.initials: I
authors.lastname: Patel
authors.forename: Ian R
authors.initials: IR
authors.lastname: Campbell
authors.forename: Helen M
authors.initials: HM
authors.lastname: Mayles
authors.forename: R Douglas
authors.initials: RD
authors.lastname: Errington
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001918:Brachytherapy / Q000379:methods*; D002830:Choroid Neoplasms / Q000517:prevention & control / Q000532:radiotherapy*; D002985:Clinical Protocols; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008545:Melanoma / Q000517:prevention & control / Q000532:radiotherapy*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000517:prevention & control; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012429:Ruthenium Radioisotopes / Q000627:therapeutic use*; D017211:Treatment Failure
chemical_list: D012429:Ruthenium Radioisotopes