Drug release from and hydrolytic degradation of a poly(ethylene glycol) grafted poly(3-hydroxyoctanoate).
Monoacrylate-poly(ethylene glycol)-grafted poly(3-hydroxyoctanoate) (PEGMA-g-PHO) copolymers were synthesized to develop a swelling-controlled release delivery system for ibuprofen as a model drug. The in vitro hydrolytic degradation of and the drug release from a film made of the PEGMA-g-PHO copolymer were carried out in a phosphate buffer saline (pH 7.4) medium. The hydrolytic degradation of the copolymer was strongly dependent on the degree of grafting (DG) of the PEGMA group. The degradation rate of the copolymer films in vitro increased with increasing DG of the PEGMA group on the PHO chain. The copolymer films showed a controlled delivery of ibuprofen to the medium in periods of time that depend on the composition, hydrophilic/hydrophobic characteristics, initial drug loading amount and film thickness of the graft copolymer support. The drug release rate from the grafted copolymer films was faster than the rate of weight loss of the films themselves. In particular, a combination of the low DG of the PEGMA group in the PHO chains with the low ibuprofen solubility in water led to long-term constant release from these matrices in vitro.
Kim
Hyung Woo
HW
Department of Microbiology, Chungnam National University, Daejeon 305-764, Korea.
Chung
Chung Wook
CW
Hwang
Sung Joo
SJ
Rhee
Young Ha
YH
D000042:Absorption; D002021:Buffers; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D006868:Hydrolysis; D007052:Ibuprofen / Q000494:pharmacology; D046911:Macromolecular Substances / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D013053:Spectrophotometry; D013997:Time Factors; D014466:Ultraviolet Rays; D014867:Water / Q000737:chemistry
D002021:Buffers; D004337:Drug Carriers; D046911:Macromolecular Substances; D011091:Polyesters; D011108:Polymers; D014867:Water; C088151:poly(3-hydroxyoctanoic acid); D011092:Polyethylene Glycols; D007052:Ibuprofen