title: Successful treatment with miltefosine of disseminated cutaneous leishmaniasis in a severely immunocompromised patient infected with HIV-1.
abstract: We describe here a case of disseminated cutaneous leishmaniasis due to Leishmania major in a severely immunocompromised patient from Burkino Faso, Africa, who is infected with human immunodeficiency virus-1. The skin lesions failed to respond to full treatment courses of amphotericin B, sodium stibogluconate, and liposomal amphotericin B but were successfully treated with miltefosine, an alkylphosphocholine analogue.
authors.affiliation: Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Christine
authors.initials: C
authors.lastname: Schraner
authors.forename: Barbara
authors.initials: B
authors.lastname: Hasse
authors.forename: Urs
authors.initials: U
authors.lastname: Hasse
authors.forename: Doris
authors.initials: D
authors.lastname: Baumann
authors.forename: Anja
authors.initials: A
authors.lastname: Faeh
authors.forename: Günther
authors.initials: G
authors.lastname: Burg
authors.forename: Felix
authors.initials: F
authors.lastname: Grimm
authors.forename: Alex
authors.initials: A
authors.lastname: Mathis
authors.forename: Rainer
authors.initials: R
authors.lastname: Weber
authors.forename: Huldrych F
authors.initials: HF
authors.lastname: Günthard
mesh_terms: D000328:Adult; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D016867:Immunocompromised Host; D016774:Leishmaniasis, Diffuse Cutaneous / Q000188:drug therapy* / Q000209:etiology*; D008297:Male; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012867:Skin / Q000473:pathology
chemical_list: D000981:Antiprotozoal Agents; D010767:Phosphorylcholine; C039128:miltefosine