Molecular signals of Mammalian circadian clock.
The circadian rhythm is originally generated by a transcription-translation based oscillatory loop composed of a set of clock genes in most organisms. The clock gene oscillation is generated by the core loop in each neuron of the hypothalamic suprachiasmatic nucleus. Phosphorylation and ubiquitination of clock proteins play the crucial role for the rhythmic transcription of clock genes. The core clock oscillation is conducted at the cellular levels by E-box or by D-box of clock controlled genes.
Zhang
Jing
J
Division of Molecular Brain Science, Department of Brain Sciences, Kobe University Graduate School of Medicine, Kobe, Japan.
Dong
Xin
X
Fujimoto
Yoshito
Y
Okamura
Hitoshi
H
D000818:Animals; D001683:Biological Clocks / Q000235:genetics*; D056926:CLOCK Proteins; D002940:Circadian Rhythm / Q000235:genetics*; D014176:Protein Biosynthesis / Q000502:physiology; D015534:Trans-Activators / Q000235:genetics*; D014158:Transcription, Genetic / Q000502:physiology
D015534:Trans-Activators; D056926:CLOCK Proteins