title: Evaluation of urinary PrPSc as a diagnostic test for sporadic, variant, and familial CJD.
abstract: Previously collected urine specimens from 100 patients referred to the UK National CJD Surveillance Unit as suspected cases of Creutzfeldt-Jakob disease (CJD) were analyzed, testing for abnormal prion protein (PrP(Sc)). In this context, the test had a low sensitivity and was not completely specific for CJD. Additionally, the proteins detected by this assay were not PrP(Sc) but appeared to be immunoglobulins.
authors.affiliation: National CJD Surveillance Unit, School of Molecular and Clinical Medicine, University of Edinburgh, UK. m.w.head@ed.ac.uk
authors.forename: M W
authors.initials: MW
authors.lastname: Head
authors.forename: E
authors.initials: E
authors.lastname: Kouverianou
authors.forename: L
authors.initials: L
authors.lastname: Taylor
authors.forename: A
authors.initials: A
authors.lastname: Green
authors.forename: R
authors.initials: R
authors.lastname: Knight
mesh_terms: D000918:Antibody Specificity / Q000276:immunology; D015153:Blotting, Western / Q000379:methods / Q000592:standards; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis* / Q000276:immunology / Q000652:urine*; D003429:Cross Reactions / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology / Q000652:urine*; D018620:PrPSc Proteins / Q000276:immunology / Q000652:urine*; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D016482:Urinalysis / Q000379:methods / Q000592:standards; D014556:Urine / Q000737:chemistry*
chemical_list: D007136:Immunoglobulins; D018620:PrPSc Proteins