Antitumor activity of crude extract and fractions from root tuber of Cynanchum auriculatum Royle ex Wight.
Antitumor activity of the ethanol extract from the root tuber of Cynanchum auriculatum Royle ex Wight and four fractions of the ethanol extract were investigated, both in vitro and in vivo. The five samples exhibited cytotoxic activity on human tumor cell lines K562, SHG44, HCT-8, A549, PC3, in vitro and inhibition in mouse implanted sarcoma S180, in vivo. Among the five samples, fraction E was noted to be of the highest antitumor activity.
Shan
Lei
L
School of Pharmacy, Second Military Medical University, Shanghai 200433, P. R. China.
Zhang
Wei-Dong
WD
Zhang
Chuan
C
Liu
Run-Hui
RH
Su
Juan
J
Zhou
Yun
Y
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D031105:Cynanchum; D004305:Dose-Response Relationship, Drug; D006801:Humans; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D012510:Sarcoma 180 / Q000473:pathology
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts