A sham stimulation-controlled trial of rTMS of the unaffected hemisphere in stroke patients.
The authors investigated the use of slow-frequency repetitive transcranial magnetic stimulation (rTMS) to the unaffected hemisphere to decrease interhemispheric inhibition of the lesioned hemisphere and improve motor function in patients within 12 months of a stroke. Patients showed a significant decrease in simple and choice reaction time and improved performance of the Purdue Pegboard test with their affected hand after rTMS of the motor cortex in the intact hemisphere as compared with sham rTMS.
Mansur
C G
CG
Harvard Center for Non-Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Fregni
F
F
Boggio
P S
PS
Riberto
M
M
Gallucci-Neto
J
J
Santos
C M
CM
Wagner
T
T
Rigonatti
S P
SP
Marcolin
M A
MA
Pascual-Leone
A
A
D000328:Adult; D000368:Aged; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006225:Hand / Q000294:innervation / Q000502:physiology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology* / Q000503:physiopathology; D009048:Motor Skills / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology / Q000503:physiopathology; D010291:Paresis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D011712:Pyramidal Tracts / Q000502:physiology / Q000503:physiopathology; D011930:Reaction Time / Q000502:physiology; D020127:Recovery of Function / Q000502:physiology; D020521:Stroke / Q000503:physiopathology / Q000628:therapy*; D013997:Time Factors; D050781:Transcranial Magnetic Stimulation / Q000379:methods* / Q000592:standards; D016896:Treatment Outcome