title: Treatment of insulinoma in a springer spaniel with streptozotocin.
abstract: An eight-year-old, female springer spaniel was treated for metastatic insulinoma with a single intravenous dose of 500 mg/m2 streptozotocin (SZN), and pre- and post-treatment diuresis. A tapering dose of corticosteroids was also administered over a 28 day period. SZN and corticosteroid administration resulted in resolution of hypoglycaemia and subsequent development of diabetes mellitus. Further metastases caused cervical spinal pain and the dog was euthanased 118 days after SZN administration. SZN can be safely used for the treatment of canine insulinoma, but, when compared with other published cases, a marked variation in clinical response to this drug exists and further study is warranted.
authors.affiliation: Department of Small Animal Clinical Studies, University of Glasgow Veterinary School, Bearsden, Glasgow G61 1QH.
authors.forename: R
authors.initials: R
authors.lastname: Bell
authors.forename: C T
authors.initials: CT
authors.lastname: Mooney
authors.forename: C S
authors.initials: CS
authors.lastname: Mansfield
authors.forename: B R
authors.initials: BR
authors.lastname: Jones
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D007340:Insulinoma / Q000188:drug therapy / Q000662:veterinary*; D009362:Neoplasm Metastasis / Q000517:prevention & control; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000662:veterinary*; D013311:Streptozocin / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000903:Antibiotics, Antineoplastic; D013311:Streptozocin