title: Microsatellite instability and p53 mutations are characteristic of subgroups of acute myeloid leukemia but independent events.
abstract: Microsatellite instability (MSI) and p53 alterations which may represent major mechanisms of genetic instability, are rarely observed in de novo acute myeloid leukemia (AML) but may play a substantial role in subgroups characterized by either a myelodysplastic prephase (sAML), previous chemotherapy (tAML) or a complex aberrant karyotype. We performed allelotyping and p53 mutation analysis in 75 patients with morphologically and cytogenetically classified AML.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Herzog
authors.forename: Juxian
authors.initials: J
authors.lastname: Lu-Hesselmann
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Zimmermann
authors.forename: Torsten
authors.initials: T
authors.lastname: Haferlach
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Hiddemann
authors.forename: Martin
authors.initials: M
authors.lastname: Dreyling
mesh_terms: D000208:Acute Disease; D000483:Alleles; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000235:genetics / Q000648:ultrastructure; D005500:Follow-Up Studies; D016158:Genes, p53; D005838:Genotype; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000145:classification / Q000235:genetics* / Q000401:mortality; D018895:Microsatellite Repeats; D016019:Survival Analysis