title: [Thyroid functional activity in an experiment upon exposure to manganeferous dust].
abstract: The purpose of the study was to examine the effect of polymetallic manganeferous dust on thyroid function in an experiment. Biochemical and cytological studies were used. Seventy-day exposure caused decreased thyroid hormonal levels and thyroid cellular composition changes, which suggest that the dust in question has a cytotoxic effect. A prolonged (3-month) exposure provided evidence that suggests the tension of adaptive mechanisms in the thyroid system under the influence of a toxic factor. Nitric oxide was found to take an active part in the formation of adaptive mechanisms in thyroid tissue.
authors.forename: Z I
authors.initials: ZI
authors.lastname: Namazbaeva
authors.forename: G M
authors.initials: GM
authors.lastname: Knashina
authors.forename: E K
authors.initials: EK
authors.lastname: Rakishev
authors.forename: M A
authors.initials: MA
authors.lastname: Mukasheva
authors.forename: L A
authors.initials: LA
authors.lastname: Bud'kova
authors.forename: R M
authors.initials: RM
authors.lastname: Baĭmukhanov
mesh_terms: D000220:Adaptation, Biological / Q000187:drug effects; D000818:Animals; D004391:Dust; D005500:Follow-Up Studies; D008297:Male; D017895:Manganese Compounds / Q000009:adverse effects* / Q000493:pharmacokinetics; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D013963:Thyroid Hormones / Q000378:metabolism
chemical_list: D004391:Dust; D017895:Manganese Compounds; D013963:Thyroid Hormones; D009569:Nitric Oxide