Cu(I) luminescence from the tetranuclear Cu4S4 cofactor of a synthetic 4-helix bundle.
The addition of Cu(I) to the random-coil peptide, C16C19-GGY, produces a self-organized, metal-bridged 4-helix bundle which displays an intense room-temperature luminescence at 600 nm. Emission, UV, and CD titrations along with X-ray absorption studies indicate that the luminescent cofactor is likely a Cu4S4 cluster in which each Cu atom is bridged by the side chains of two cysteine residues and has terminal N/O ligation.
Kharenko
Olesya A
OA
Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403, USA.
Kennedy
David C
DC
Demeler
Borries
B
Maroney
Michael J
MJ
Ogawa
Michael Y
MY
D000595:Amino Acid Sequence; D002942:Circular Dichroism; D003300:Copper / Q000737:chemistry*; D005583:Fourier Analysis; D008163:Luminescent Measurements; D008667:Metalloproteins / Q000737:chemistry*; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D013057:Spectrum Analysis; D013440:Sulfides / Q000737:chemistry*
D008667:Metalloproteins; D013440:Sulfides; D003300:Copper