1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors.
Brik
Ashraf
A
Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Alexandratos
Jerry
J
Lin
Ying-Chuan
YC
Elder
John H
JH
Olson
Arthur J
AJ
Wlodawer
Alexander
A
Goodsell
David S
DS
Wong
Chi-Huey
CH
D000998:Antiviral Agents / Q000138:chemical synthesis*; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis*; D015497:HIV-1 / Q000201:enzymology*; D006860:Hydrogen Bonding; D008958:Models, Molecular; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000737:chemistry*
D000998:Antiviral Agents; D017320:HIV Protease Inhibitors; D014230:Triazoles