Steryl epoxide, secobutanolide and butanolides from the stem wood of Machilus zuihoensis.
A steryl epoxide, machillene (1), a secobutanolide, secomahubanolide (2), and two butanolides, zuihoenalide (3), and 3-(1-methoxyoctadecyl)-5-methylene-5H-furan-2-one (4), together with 12 known compounds, were isolated from stem wood of Machilus zuihoensis. Their structures were determined by means of spectroscopic analyses. Machillene (1) showed cytotoxic activity against NUGC-3 and HONE-1 cancer cell lines in vitro.
Cheng
Ming-Jen
MJ
Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Republic of China.
Tsai
Ian-Lih
IL
Lee
Shoiw-Ju
SJ
Jayaprakasam
Bolleddula
B
Chen
Ih-Sheng
IS
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology; D002073:Butanes / Q000737:chemistry; D045744:Cell Line, Tumor; D004852:Epoxy Compounds / Q000737:chemistry*; D005663:Furans / Q000737:chemistry*; D006801:Humans; D019770:Lauraceae / Q000737:chemistry*; D015394:Molecular Structure; D014934:Wood
C502886:3-(1-methoxyoctadecyl)-5-methylene-5H-furan-2-one; D000972:Antineoplastic Agents, Phytogenic; D002073:Butanes; D004852:Epoxy Compounds; D005663:Furans