Mapping of genetic and epigenetic regulatory networks using microarrays.
The highly coordinated expression of thousands of genes in an organism is regulated by the concerted action of hundreds of transcription factors and chromatin proteins, as well as by epigenetic mechanisms. Understanding the architecture of these vastly complex regulatory networks is one of the main challenges in the postgenomic era. New microarray-based techniques have become available for the genome-wide mapping of in vivo protein-DNA interactions and epigenetic marks. Data sets obtained with these techniques begin to offer the first comprehensive views of genetic and epigenetic regulatory networks.
van Steensel
Bas
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the Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands. b.v.steensel@nki.nl
D000818:Animals; D001665:Binding Sites; D002843:Chromatin / Q000502:physiology; D019175:DNA Methylation; D004268:DNA-Binding Proteins; D005786:Gene Expression Regulation; D016678:Genome; D006570:Heterochromatin; D006657:Histones; D006801:Humans; D009707:Nucleosomes; D020411:Oligonucleotide Array Sequence Analysis; D012323:RNA Processing, Post-Transcriptional; D012045:Regulatory Sequences, Nucleic Acid; D014157:Transcription Factors
D002843:Chromatin; D004268:DNA-Binding Proteins; D006570:Heterochromatin; D006657:Histones; D009707:Nucleosomes; D014157:Transcription Factors