title: CD5+ diffuse large B-cell lymphoma with c-myc/IgH rearrangement presenting as primary effusion lymphoma.
abstract: We report an instructive case of diffuse large B-cell lymphoma presenting as acute heart failure. A 69-year-old human immunodeficiency virus-negative man was admitted to our hospital for general fatigue. A computed tomographic scan of the chest and abdomen showed pericardial effusion, but there was no evidence of tumor masses, lymph node enlargement, or hepatosplenomegaly. During the chemotherapy, increased lactate dehydrogenase and pleural effusion appeared. The tumor cells in the effusion showed positivity for CD5, CD19, CD20, kappa chain, and Bcl-2 and negativity for CD10 and CD23. The chromosomes showed t(8;14)(q24;q32) with c-myc/immunoglobulin (Ig)H rearrangement, and the MIB-1 index was not high (60%). Neither human herpes virus 8 nor Epstein-Barr virus DNA was detected in the cells by polymerase chain reaction. The response to chemotherapy was very poor, and the patient died 4 months after the diagnosis. A spectrum of the symptoms of CD5+ lymphoma encompasses pericardial effusion and also can accompany c-myc/IgH rearrangement.
authors.affiliation: Department of Infectious Disease, Hamamatsu Medical Center, Hamamatsu 432-8580, Japan. shinfuji@hmedc.or.jp
authors.forename: Shinya
authors.initials: S
authors.lastname: Fujisawa
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Tanioka
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Matsuoka
authors.forename: Takachika
authors.initials: T
authors.lastname: Ozawa
mesh_terms: D000368:Aged; D018956:CD5 Antigens / Q000032:analysis; D015321:Gene Rearrangement; D016259:Genes, myc; D006801:Humans; D007136:Immunoglobulins; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000235:genetics* / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000235:genetics*; D008297:Male; D010490:Pericardial Effusion / Q000209:etiology*; D010996:Pleural Effusion / Q000209:etiology*
chemical_list: D018956:CD5 Antigens; D007136:Immunoglobulins