Short and novel stereospecific synthesis of trisubstituted 2,5-diketopiperazines.
Novel syntheses of chiral trisubstituted 2,5-diketopiperazines using multicomponent Ugi reactions were developed.
Sollis
Steven L
SL
Department of Medicinal Chemistry, Cardiovascular and Urogenital CEDD, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts SG1 2NY, United Kingdom. Steve.L.Sollis@gsk.com
D020650:Combinatorial Chemistry Techniques; D054659:Diketopiperazines; D015394:Molecular Structure; D010879:Piperazines / Q000138:chemical synthesis*; D013237:Stereoisomerism
D054659:Diketopiperazines; D010879:Piperazines