title: Synthesis and evaluation of 3-methyl-4-oxo-6-phenyl-4,5,6,7-tetrahydrobenzofuran-2-carboxylic acid ethyl ester derivatives as potent antitumor agents.
abstract: For the construction of new combinatorial libraries, a lead compound was created by replacing the core structure of a hit compound discovered by screening for cytotoxic agents against a tumorigenic cell line. The newly designed compound maintained biological activity and allowed alternative library construction for antitumor drugs.
authors.affiliation: Lead Discovery Research Laboratories, Sankyo Co., Ltd., Shinagawa-ku, Tokyo 140-8710, Japan. hayaka@sankyo.co.jp
authors.forename: Ichiro
authors.initials: I
authors.lastname: Hayakawa
authors.forename: Rieko
authors.initials: R
authors.lastname: Shioya
authors.forename: Toshinori
authors.initials: T
authors.lastname: Agatsuma
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Sugano
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001572:Benzofurans / Q000138:chemical synthesis* / Q000494:pharmacology; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004952:Esters; D006801:Humans
chemical_list: D000970:Antineoplastic Agents; D001572:Benzofurans; D002264:Carboxylic Acids; D004952:Esters