title: Bone marrow metastases from glioblastoma multiforme--A case report and review of the literature.
abstract: Clinically detected extra-cranial metastases from glioblastoma multiforme (GBM) are quite rare, with an incidence of <2% reported in the published literature. Among the various reported sites of systemic metastases from GBM, there are few cases of clinically symptomatic bone marrow metastasis. The case of a patient developing systemic dissemination of a GBM is described. A 60-year-old man with GBM who developed back pain, thrombocytopenia and subsequently neurological deficits was found to have extensive bony and bone marrow metastases. Previously reported cases of extra-cranial systemic spread of GBM and attempts made in the literature to explain the possible routes of extra-neural dissemination are reviewed.
authors.affiliation: Hematology-Oncology Unit, St. Luke's Roosevelt Hospital Center, New York, NY 10019, USA.
authors.forename: Vandana
authors.initials: V
authors.lastname: Rajagopalan
authors.forename: Francois G
authors.initials: FG
authors.lastname: El Kamar
authors.forename: Rose
authors.initials: R
authors.lastname: Thayaparan
authors.forename: Michael L
authors.initials: ML
authors.lastname: Grossbard
mesh_terms: D019046:Bone Marrow Neoplasms / Q000556:secondary*; D001859:Bone Neoplasms / Q000556:secondary*; D001932:Brain Neoplasms / Q000473:pathology*; D017809:Fatal Outcome; D005909:Glioblastoma / Q000556:secondary*; D006801:Humans; D017116:Low Back Pain / Q000209:etiology / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D035583:Rare Diseases