Synthesis and biological evaluation of novel bisphosphonates with dual activities on bone in vitro.
In an effort to generate novel anti-osteoporosis agents, new bisphosphonates with various benzoyl groups on side chains have been synthesized and evaluated for activities on both bone resorption and bone formation in vitro. Several candidates showed distinct dual activities: promoting bone formation and inhibiting bone resorption.
Xie
Yuli
Y
Department of Medicine, Columbia University, NY 10032, USA.
Ding
Huasheng
H
Qian
Lihui
L
Yan
Xueming
X
Yang
Chunhao
C
Xie
Yuyuan
Y
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D016723:Bone Remodeling / Q000187:drug effects*; D001862:Bone Resorption; D049109:Cell Proliferation / Q000187:drug effects; D004164:Diphosphonates / Q000138:chemical synthesis* / Q000494:pharmacology; D010010:Osteoclasts / Q000166:cytology / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects; D010024:Osteoporosis / Q000188:drug therapy; D051381:Rats; D013329:Structure-Activity Relationship
D015415:Biomarkers; D004164:Diphosphonates