[Effect of inorganic nitrates on the morphofunctional condition of the kidney in the rat].
OBJECTIVE
The aim of our experimental study was to determine the effect of exogenic nitrates on certain biological parameters in relation to renal insufficiency.


RESULTS
Chronic treatment of rats for 5 months with varying nitrate concentrations (50, 100, 150 and 500 mg/L) induced a dose-dependent reduction in plasma concentrations of total proteins and a dose-dependent increase in plasma urea concentrations and creatinine.


CONCLUSIONS
This histological study of the kidney shows that nitrates at doses of 150 and 500 mg/L cause a deterioration in the epithelia of the renal tubules.


CONCLUSIONS
In conclusion, a high nitrate intake induces morphofunctional disturbances of the kidney and could thus be regarded as a causative factor in renal insufficiency.
Zaki
Abdelwahab
A
Laboratoire de Physiologie Animale, Faculté des Sciences et Techniques, Béni Mellal, Maroc. zakix@doctor.com
Chaoui
Ahmed Ait
AA
Chait
Abderahman
A
Aboussaouira
Touria
T
Zarrouk
Khadija
K
Himmi
Thami
T
D000818:Animals; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000473:pathology; D007677:Kidney Function Tests; D008297:Male; D009566:Nitrates / Q000097:blood / Q000633:toxicity*; D011507:Proteinuria / Q000139:chemically induced; D051381:Rats; D017208:Rats, Wistar; D051437:Renal Insufficiency / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology
D009566:Nitrates; D003404:Creatinine