[The clinical application of acellular dermal matrix to repair the defect of oral mucosa].
OBJECTIVE
To evaluate the clinical effect of acellular dermal matrix allograft in repairing the defect of oral mucosa.


METHODS
Forty-two cases of large superficial defects in oral cavity were repaired by acellular dermal matrix. Defect areas included vestibule, tongue, the floor of mouth, buccal mucosa, palate, gingival and lip. Defect size was between 2.25 cm(2) and 12 cm(2). The basement membrane side of acellular dermal matrix was exposed to oral cavity, and another side was attached to the surgical wound surface. It was fixed by suture, reverse strapping and prepared template to overlaid large superficial defect of oral mucosa. The patients were followed up from 3 months to 1 year after operation.


RESULTS
The wounds were completely healed in 40 cases, partially healed in 2 cases. There was no failure case. The healing was divided into two types: epithelialization healing pattern in 12 cases, attached healing pattern in 30 cases. Contraction of grafts occurred at 2 - 4 weeks. The contraction rate was 3.7% +/- 1.1% at fourth week. Scarring did not appear.


CONCLUSIONS
The clinical result of acellular dermal matrix allograft in repair the defect of oral mucosa is good. Acellular dermal matrix can be taken as a substitute to autograft of skin.
Zhang
Wei
W
Department of Oral and Maxillofacial Surgery, Peking University School of Stomatology, 100081Beijing, China. kqzhangwei@bjmu.edu.cn
Hu
Min
M
Wang
En-bo
EB
Bu
Jing-qiu
JQ
D000328:Adult; D000368:Aged; D020405:Dermis / Q000166:cytology / Q000637:transplantation*; D005109:Extracellular Matrix / Q000637:transplantation*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology / Q000601:surgery*; D014184:Transplantation, Homologous