title: [Results from the observational study EPIGRAM: management of excess weight in general practice and follow-up of patients treated with orlistat].
abstract: The EPIGRAM pharmacoepidemiological study was conducted in general practitioners (GPs) prescribing orlistat (Xenical) in order to describe, under real clinical conditions, the management of obese or overweight patients, as well as a 1-year follow-up of a patient cohort treated with orlistat. A total of 714 GPs participated in this study and recruited a total of 6801 patients. Forty percent were treated with orlistat, 76% were women and 63% presented with a comorbidity. With a mean body mass index of 33.1+/-5.1 kg/m2, 85% of the patients treated with orlistat were in agreement with the indications of this drug. Comparison of patients treated and not treated with orlistat did not allow identification of any key factor able to predict prescription of the treatment. Patients treated with orlistat on inclusion and reviewed at least once by their doctor were followed up for an average of 11 months and a maximum of 23 months. Between 64% and 77% of patients stopped treatment with orlistat during the follow-up period. The treatment cost was the main reason for definitive treatment discontinuation for more than 50% of the patients. The average weight loss was 5% and 9% after 3 and 12 months of treatment, respectively.
authors.affiliation: Institut Pasteur, Bâtiment Laveran, Paris, France. vray@pasteur.fr
authors.forename: Muriel
authors.initials: M
authors.lastname: Vray
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Joubert
authors.forename: Eveline
authors.initials: E
authors.lastname: Eschwège
authors.forename: François
authors.initials: F
authors.lastname: Liard
authors.forename: Francis
authors.initials: F
authors.lastname: Fagnani
authors.forename: François
authors.initials: F
authors.lastname: Montestruc
authors.forename: Sophie
authors.initials: S
authors.lastname: Fages
authors.forename: Bernard
authors.initials: B
authors.lastname: Bégaud
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019440:Anti-Obesity Agents / Q000009:adverse effects / Q000627:therapeutic use*; D015992:Body Mass Index; D001835:Body Weight; D005194:Family Practice; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007783:Lactones / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy*; D000077403:Orlistat
chemical_list: D019440:Anti-Obesity Agents; D007783:Lactones; D000077403:Orlistat