1H and 13C NMR spectral assignment of androstane derivatives.
(1)H and (13)C NMR spectroscopic data for 5alpha-androstanes and halo-5alpha-androstanes with different substituents at positions C-3, C-9, C-11 and C-17 were examined and assigned by a combination of 1D and 2D NMR experiments. The substituent effects on the (13)C chemical shifts were compared with those of epi-androsterone, used as a reference compound. The coupling constants (n)J((19)F,(13)C) were measured for compounds 6, 8, 11 and 14.
Fuente
Ariadna
A
Centro de Química Farmacéutica, Apartado Postal 16042, Ciudad de La Habana, Cuba.
Reyes
Mayra
M
Alvarez
Yoanna M
YM
Ruiz
José A
JA
Vélez
Hermán
H
Viñas-Bravo
Omar
O
Montiel-Smith
Sara
S
Meza-Reyes
Socorro
S
Sandoval-Ramírez
Jesús
J
D000731:Androstanes / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods* / Q000592:standards*; D008968:Molecular Conformation; D012016:Reference Values
D000731:Androstanes