[Study on the relations between serum insulin-like growth factor-1, insulin-like growth factor binding protein-3 and colorectal cancer: a meta-analysis].
OBJECTIVE
To evaluate the relationship between circulating levels of insulin-like growth factor-1 (IGF-1), IGF-binding protein-3 (IGFBP-3) and colorectal cancer.


METHODS
A meta-analysis of 6 epidemiological studies on insulin-like growth factors and risk of colorectal cancer were performed.


RESULTS
The pooled odds ratio (OR) of IGF-1 and IGFBP-3 were 1.56 (95% CI: 1.14-2.13) and 0.78 (95% CI: 0.43-1.44) respectively. According to the results from different measurements (enzyme-linked immunoabsorbent assay and immunoradiometric assay), the pooled OR were 1.92 and 1.23 for IGF-1, 0.46 and 1.44 for IGFBP-3 respectively.


CONCLUSIONS
High serum levels of IGF-1 were independent risk factors of colorectal cancer but the OR of IGFBP-3 was not statistically significant. The heterogeneity between studies on IGFBP-3 and colorectal cancer was caused by different measurements used, but there was still a need to conduct simultaneous large size study under 2 different measurements for further conclusion.
Duan
Qiong-hong
QH
The Department of Epidemiology, Tongji Medical College, Huazhong University of Science and Thenology, Wuhan 430030, China.
Wang
Zhi-gang
ZG
Zhu
Gui-bao
GB
Lu
Zu-xun
ZX
Shi
Lv-yuan
LY
Nie
Shao-fa
SF
D002681:China / Q000453:epidemiology; D015179:Colorectal Neoplasms / Q000097:blood / Q000453:epidemiology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D011863:Radioimmunoassay; D012307:Risk Factors
D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I