Cytotoxicity, antitumoral and antimycobacterial activity of tetrazole and oxadiazole derivatives.
In this study, the antimycobacterial activity of mono and di-substituted tetrazole and oxadiazole derivatives and their precursors was assayed on Mycobacterium tuberculosis H37Rv, and cytotoxicity was evaluated on J774 macrophages and on tumoral cell lines. Structure Activity Relationship (SAR) analysis was performed using Principal Component Analysis (PCA) to determine the relationship between these compounds and their biological activities.
De Souza
A O
AO
Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, S.P., Brazil. olivia@butantan.gov.br
Pedrosa
M T C
MT
Alderete
J B
JB
Cruz
A F
AF
Prado
M A F
MA
Alves
R B
RB
Silva
C L
CL
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009161:Mycobacterium / Q000187:drug effects*; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D013778:Tetrazolium Salts; D013844:Thiazoles
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D010069:Oxadiazoles; D013777:Tetrazoles; D013778:Tetrazolium Salts; D013844:Thiazoles; C022616:thiazolyl blue