title: Ileal ulcers and cytomegalovirus infection in a case of Churg-Strauss syndrome.
abstract: Churg-Strauss syndrome, or allergic granulomatous angiitis, is an uncommon vasculitic syndrome. We describe a 53-year-old man with Churg-Strauss syndrome and subsequent opportunistic cytomegalovirus enterocolitis. During intensive care, including steroid-pulse therapy, the patient developed rapidly progressive anemia caused by active bleeding from his small intestine, resulting in resection of 20 cm of ileum. Diagnosis of Churg-Strauss syndrome was confirmed both by characteristic clinical features and by histology. Histologic examination also revealed multiple shallow ulcers accompanied by cytomegalovirus infection. Characteristic angiitis was found in the ileum with normal-like mucosa, and it was not necessarily associated with ileal ulcers. This finding suggests that cytomegalovirus infection may be one of the causes or exacerbating factors for ileal ulcers in Churg-Strauss syndrome, although ulcers of the intestine have usually been considered to be caused by ischemia resulting from angiitis.
authors.affiliation: Division of Pathology, Department of Pathology and Microbiology, Tottori University Faculty of Medicine, Yonago, Japan. hayashik@grape.med.tottori-u.ac.jp
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Hayashi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Horie
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takahata
authors.forename: Youshin
authors.initials: Y
authors.lastname: Adachi
authors.forename: Yukisato
authors.initials: Y
authors.lastname: Kitamura
authors.forename: Masako
authors.initials: M
authors.lastname: Kato
mesh_terms: D000740:Anemia / Q000209:etiology / Q000473:pathology; D015267:Churg-Strauss Syndrome / Q000188:drug therapy / Q000473:pathology* / Q000821:virology; D003587:Cytomegalovirus / Q000302:isolation & purification* / Q000472:pathogenicity; D003586:Cytomegalovirus Infections / Q000150:complications / Q000473:pathology*; D004305:Dose-Response Relationship, Drug; D004760:Enterocolitis / Q000473:pathology / Q000821:virology; D006801:Humans; D007077:Ileal Diseases / Q000473:pathology* / Q000601:surgery / Q000821:virology; D007082:Ileum / Q000473:pathology / Q000601:surgery / Q000821:virology; D007121:Immunocompetence / Q000187:drug effects; D016867:Immunocompromised Host; D007413:Intestinal Mucosa / Q000473:pathology / Q000821:virology; D008297:Male; D008775:Methylprednisolone / Q000009:adverse effects; D008875:Middle Aged; D009894:Opportunistic Infections / Q000150:complications / Q000473:pathology*; D014456:Ulcer / Q000473:pathology* / Q000601:surgery / Q000821:virology
chemical_list: D008775:Methylprednisolone