title: Aspects of computer-aided detection (CAD) and volumetry of pulmonary nodules using multislice CT.
abstract: With the superb spatial resolution of modern multislice CT scanners and their ability to complete a thoracic scan within one breath-hold, software algorithms for computer-aided detection (CAD) of pulmonary nodules are now reaching high sensitivity levels at moderate false positive rates. A number of pilot studies have shown that CAD modules can successfully find overlooked pulmonary nodules and serve as a powerful tool for diagnostic quality assurance. Equally important are tools for fast and accurate three-dimensional volume measurement of detected nodules. These allow monitoring of nodule growth between follow-up examinations for differential diagnosis and response to oncological therapy. Owing to decreasing partial volume effect, nodule volumetry is more accurate with high resolution CT data. Several studies have shown the feasibility and robustness of automated matching of corresponding nodule pairs between follow-up examinations. Fast and automated growth rate monitoring with only few reader interactions also adds to diagnostic quality assurance.
authors.affiliation: Philips Research Laboratories Hamburg, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Wiemker
authors.forename: P
authors.initials: P
authors.lastname: Rogalla
authors.forename: T
authors.initials: T
authors.lastname: Blaffert
authors.forename: D
authors.initials: D
authors.lastname: Sifri
authors.forename: O
authors.initials: O
authors.lastname: Hay
authors.forename: E
authors.initials: E
authors.lastname: Shah
authors.forename: R
authors.initials: R
authors.lastname: Truyen
authors.forename: T
authors.initials: T
authors.lastname: Fleiter
mesh_terms: D003937:Diagnosis, Differential; D005189:False Positive Reactions; D006801:Humans; D008171:Lung Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*