title: WIN 55,212-2 decreases the spatial spread of neocortical excitation in vitro.
abstract: The 'intrinsic optical signal' was used to monitor neuronal network excitability. The cannabinoid receptor type 1 agonist WIN 55,212-2 reduced the intensity and the spatial spread of the intrinsic optical signal and prolonged its kinetics in the rat neocortex in vitro. These effects were antagonized by the cannabinoid receptor antagonist SR141716A. Thus, our results suggest that neocortical network activity is modulated via the activation of cannabinoid receptors. The decrease of neocortical network excitability in the present study is probably due to a decreased excitability of glutamatergic neurons.
authors.affiliation: Max-Planck Institute of Psychiatry, Clinical Neuropharmacology, Kraepelinstrasse 2, 80804 Munich, Germany. becker@mpipsykl.mpg.de
authors.forename: Klaus
authors.initials: K
authors.lastname: Becker
authors.forename: Matthias
authors.initials: M
authors.lastname: Eder
authors.forename: Walter
authors.initials: W
authors.lastname: Zieglgänsberger
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Dodt
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D048588:Benzoxazines; D013181:Cortical Spreading Depression / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects; D003952:Diagnostic Imaging / Q000379:methods; D004558:Electric Stimulation / Q000379:methods; D066298:In Vitro Techniques; D009025:Morpholines / Q000494:pharmacology*; D009281:Naphthalenes / Q000494:pharmacology*; D019579:Neocortex / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D043884:Receptor, Cannabinoid, CB1 / Q000819:agonists*; D013997:Time Factors
chemical_list: D048588:Benzoxazines; D009025:Morpholines; D009281:Naphthalenes; D043884:Receptor, Cannabinoid, CB1; C070417:(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone