title: [Diagnostic value of adenosine (99m)Tc-MIBI myocardial perfusion imaging for detecting coronary artery disease].
abstract: OBJECTIVE
  The aim of this study was to assess the accuracy of adenosine (99m)Tc-MIBI myocardial perfusion SPECT for the diagnosis of coronary artery disease.
  
  
  METHODS
  A total of 89 patients [mean age (57 +/- 9) years,62 men, 27 women] were included in this study. Adenosine was infused intravenously at a rate of 140 microg.kg(-1).min(-1) for 6 minutes. At the end of 3 minute of adenosine infusion, 925MBq of (99m)Tc-MIBI was injected intravenously. SPECT myocardial imaging acquisition was obtained 1 hour after adenosine infusion. Coronary angiography was performed in all patients.
  
  
  RESULTS
  Thirty-one patients had significant coronary artery stenosis and 58 had normal coronary angiography. Adenosine myocardial perfusion imaging was abnormal in twenty-two out of the 31 patients with significant coronary artery stenosis (sensitivity, 71%). Fifty-three out of the 58 patients with normal angiography had a normal adenosine myocardial perfusion imaging (specificity, 91%). The positive predictive value and negative predictive value of adenosine (99m)Tc-MIBI myocardial perfusion imaging for detection of coronary artery disease was 81% and 84% respectively.
  
  
  CONCLUSIONS
  Adenosine myocardial perfusion imaging is probably an accurate method for detecting coronary artery disease.
authors.affiliation: Department of Nuclear Medicine, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100037, China.
authors.forename: Yue-qin
authors.initials: YQ
authors.lastname: Tian
authors.forename: Jin-cheng
authors.initials: JC
authors.lastname: Wang
authors.forename: Zuo-xiang
authors.initials: ZX
authors.lastname: He
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Feng-huan
authors.initials: FH
authors.lastname: Hu
authors.forename: Wei-xian
authors.initials: WX
authors.lastname: Yang
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.forename: Hao-jie
authors.initials: HJ
authors.lastname: Dai
authors.forename: Zhi-ming
authors.initials: ZM
authors.lastname: Yao
mesh_terms: D000241:Adenosine; D000328:Adult; D000368:Aged; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D015635:Radionuclide Ventriculography; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon; D055815:Young Adult
chemical_list: D017256:Technetium Tc 99m Sestamibi; D000241:Adenosine