title: A pilot study of mifepristone and misoprostol administered at the same time for abortion in women with gestation from 50 to 63 days.
abstract: BACKGROUND
  In the interest of decreasing the amount of time it takes to achieve a medical abortion, we performed a pilot study to evaluate the simultaneous administration of mifepristone and vaginal misoprostol for women with gestation from 50 to 63 days.
  
  
  METHODS
  Forty women were enrolled with undesired pregnancies from 50 to 56 days' gestation (group 1) and 40 from 57 to 63 days' gestation (group 2). All women used misoprostol 800 mug vaginally immediately after having swallowed the 200 mg mifepristone tablet. Follow-up evaluations with transvaginal ultrasonography occurred at 24 h and 2 weeks after treatment.
  
  
  RESULTS
  The 24-h expulsion rates were 88% (95% CI, 77-98) and 83% (95% CI, 7-94) in groups 1 and 2, respectively. The complete abortion rates at 2 weeks were 93% (95% CI, 84-100) and 90% (95% CI, 81-99), respectively.
  
  
  CONCLUSIONS
  Simultaneous administration of oral mifepristone and vaginal misoprostol provides 24-h expulsion rates in women with gestation from 50 to 63 days, comparable to those reported in the medical literature for standard treatment regimens. Further study of this regimen in a large randomized trial is warranted.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine and Magee-Womens Research Institute, Pittsburgh, PA 15213, USA. cschreiber@mail.magee.edu
authors.forename: Courtney A
authors.initials: CA
authors.lastname: Schreiber
authors.forename: Mitchell D
authors.initials: MD
authors.lastname: Creinin
authors.forename: Bryna
authors.initials: B
authors.lastname: Harwood
authors.forename: Amitasrigowri S
authors.initials: AS
authors.lastname: Murthy
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage*; D000028:Abortion, Induced; D000328:Adult; D005260:Female; D005865:Gestational Age; D006801:Humans; D008600:Menstruation-Inducing Agents / Q000008:administration & dosage*; D015735:Mifepristone / Q000008:administration & dosage*; D016595:Misoprostol / Q000008:administration & dosage*; D010865:Pilot Projects; D011247:Pregnancy; D013997:Time Factors
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D008600:Menstruation-Inducing Agents; D016595:Misoprostol; D015735:Mifepristone