[Valproate-dependent changes in the spectrum of free amino acids in rats: l-carnitine effects].
The effect of L-camitine (LC) in a dose of 100 mg/kg on the spectrum of free amino acids in the tissues and blood plasma was studied in rats pretreated for 8 days with valproic acid (VA) in a dose of 200 mg/kg. The VA treatment led to a decrease in the concentration of Ser, Gln, and Ala in the blood plasma and of Gln, Cys, Phe, and His in the liver, and to an increase in the level of Tau, Thr, Gly, alpha-Aba, Ile, and Tyr in the liver. In the rat brain, the concentration of PEA, urea, Ile, Val, Tyr, Phe, and alpha-Aba increased, while the Orn level decreased. The introduction of LC led to correction of the dysbalance of free amino acids, whereby the levels of Asp, Ctn, and Orn in the blood plasma and the levels of Cys and Tyr in the liver were increased, while the levels of Thr, Cly, alpha-Aba, and Ile in the liver and the levels of alpha-Aba, Val, and Phe in the brain were decreased. The character of variation of the spectrum of free amino acids and their derivatives in the tissues and blood plasma of rats confirms the toxicity of VA and shows the ability of LC to normalize (to a certain extent) the balance violated by the VA-induced LC insufficiency.
Bykov
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D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D000927:Anticonvulsants / Q000037:antagonists & inhibitors / Q000633:toxicity*; D001921:Brain / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D002331:Carnitine / Q000008:administration & dosage*; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014635:Valproic Acid / Q000037:antagonists & inhibitors / Q000633:toxicity*
D000596:Amino Acids; D000927:Anticonvulsants; D014635:Valproic Acid; D002331:Carnitine