Heteroarylisopropylamines as MAO inhibitors.
The in vitro monoamine oxidase inhibitory (MAOI) activities of 11 heteroarylisopropylamines vis-à-vis MAO-A and MAO-B were described and interpreted in terms of possible interactions with the enzyme active site. Molecular dynamics simulations allowed a comparison between the most active MAO-A inhibitor of the series, the 1-(2-benzofuryl)-2-aminopropane, and the specific, analogous MAO-A substrate serotonin.
Vallejos
Gabriel
G
Facultad de Química y Biología, Universidad de Santiago, Casilla 40, Correo 33, Santiago, Chile.
Fierro
Angélica
A
Rezende
Marcos Caroli
MC
Sepúlveda-Boza
Silvia
S
Reyes-Parada
Miguel
M
D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008996:Monoamine Oxidase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011437:Propylamines / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared
D008996:Monoamine Oxidase Inhibitors; D011437:Propylamines; C035263:2-propylamine