title: Cornelia de Lange Syndrome and the link between chromosomal function, DNA repair and developmental gene regulation.
abstract: Cornelia de Lange Syndrome (CdLS) is a rare multiple malformation disorder with characteristic facial features, growth and cognitive retardation, and many other abnormalities. CdLS individuals were recently shown to have heterozygous mutations in a previously uncharacterised gene, NIPBL, which encodes delangin, a homologue of fungal Scc2-type sister chromatid cohesion proteins and the Drosophila Nipped-B developmental regulator. Nipped-B and vertebrate delangins are also now known to regulate sister chromatid cohesion, probably as part of oligomeric complexes required to load cohesin subunits onto chromatin. CdLS is likely to be one of several developmental disorders resulting from defective expression of a multi-functional protein with roles in chromosome function, gene regulation and double-strand DNA repair - a combination of properties shared by certain bacterial proteins responsible for structural maintenance of chromatin.
authors.affiliation: Institute of Human Genetics and Centre for Stem Biology and Developmental Genetics, University of Newcastle, International Centre for Life, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK. tom.strachan@ncl.ac.uk
authors.forename: Tom
authors.initials: T
authors.lastname: Strachan
mesh_terms: D000818:Animals; D002875:Chromosomes / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D003635:De Lange Syndrome / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D006801:Humans; D010641:Phenotype