Effects of anaesthetic agents in interference of naloxone-induced opiate-withdrawal are dose-dependent in opiate-dependent rats.
In opiate-dependent rats previous studies showed that anaesthetic agents, such as chloral hydrate, midazolam and ketamine interfere with naloxone-precipitated opiate withdrawal. Each anaesthetic induces a specific pattern of interference, indicating that the interference is agent-dependent. In order to further investigate these effects and highlight a potential pharmacological basis of opiate withdrawal interference through anaesthetic agents, we hypothesized that anaesthetic-mediated interference of opiate withdrawal is also dose-dependent. Three groups of rats were compared in an experimental procedure of rapid withdrawal induction by an antagonist under anaesthesia using sub-anaesthetic dosage of midazolam, ketamine or saline. We observed that sub-anaesthetic dosage of ketamine, or midazolam, interferes significantly with opiate withdrawal expression. This brings arguments in favour of a pharmacological basis underlying rapid antagonists induction in opiate dependent rats.
Streel
Emmanuel
E
CHU Brugmann (Université Libre de Bruxelles), Institut de Psychiatrie, Clinique d'Alcoologie and Toxicomanies, Brussels, Belgium. manu.streel@chu-brugmann.be
Dan
Bernard
B
Antoniali
Valérie
V
Clement
Béatrice
B
Campanella
Salvatore
S
Hanak
Catherine
C
Vanderlinden
Philippe
P
Pelc
Isy
I
Verbanck
Paul
P
D000777:Anesthetics / Q000008:administration & dosage* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D009270:Naloxone / Q000633:toxicity*; D009293:Opioid-Related Disorders / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy* / Q000378:metabolism
D000777:Anesthetics; D009270:Naloxone