Short-term paroxetine treatment does not alter the motor response to levodopa in PD.
The authors examined the motor effects of 2 weeks of paroxetine, a serotonin reuptake inhibitor (SSRI), and placebo on responses to 2-hour levodopa infusions in 14 subjects with Parkinson disease. Paroxetine did not affect tapping scores or dyskinesia. Baseline walking speed (preinfusion) increased on paroxetine, often associated with an increased subjective perception of worsened balance.
Chung
Kathryn A
KA
Oregon Health and Science University, Portland, OR 97239-3098, USA. chungka@ohsu.edu
Carlson
Nichole E
NE
Nutt
John G
JG
D000058:Accidental Falls / Q000517:prevention & control; D000368:Aged; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D018592:Cross-Over Studies; D004244:Dizziness / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology; D004298:Dopamine / Q000378:metabolism; D015259:Dopamine Agents / Q000494:pharmacology; D004311:Double-Blind Method; D004347:Drug Interactions / Q000502:physiology; D005260:Female; D020233:Gait Disorders, Neurologic / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D017374:Paroxetine / Q000009:adverse effects / Q000494:pharmacology*; D017729:Presynaptic Terminals / Q000187:drug effects / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000494:pharmacology*; D017211:Treatment Failure; D015837:Vestibular Diseases / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology
D004298:Dopamine; D015259:Dopamine Agents; D007980:Levodopa; D017374:Paroxetine; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors