Cyclic peroxides derived from the marine sponge Plakortis simplex.
Two new cyclic peroxides, 2 and 3, were isolated from a sample of the Norwegian sponge Plakortis simplex. Their structures including relative stereochemistry were elucidated by interpretation of MS and NMR data. Compound 3 exhibited moderate in vitro activity against six solid human tumor cell lines with IC50 values in the range 7-15 microg/mL.
Holzwarth
Michael
M
Institut für Biogeochemie und Meereschemie, Universität Hamburg, Bundesstrasse 55, D-20146 Hamburg, Germany.
Trendel
Jean-Michel
JM
Albrecht
Pierre
P
Maier
Armin
A
Michaelis
Walter
W
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003500:Cyclization; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009664:Norway; D010545:Peroxides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D010545:Peroxides