title: Is inhibin B involved in the toxic effect of lead on male reproduction?
abstract: Human studies indicate exposure to lead is associated with decreased sperm quality with modest, if any, effects on conventional reproductive endocrine profile. Inhibin B is a marker of Sertoli cell function and spermatogenesis. The present study evaluates possible effects of lead exposure on serum levels of inhibin B in a group of lead workers as compared with a non-exposed group of hospital personnel. The study population included 68 healthy Belgian workers from a lead smelter (Hoboken, Belgium) and for comparison a control group of 91 hospital personnel (University Hospital Ghent, Belgium). Semen analysis and measurement of current blood lead levels and serum levels of inhibin B, follicle stimulating hormone (FSH) and estradiol (E2). Lead workers had significantly lower sperm concentration (35 vs. 51 million/mL) and higher serum inhibin B (259 vs. 177 pg/mL) as well as lead blood levels 30.9 vs. 3.4 mug/dL) compared with the hospital personnel (all p < 0.05). Serum FSH and E2 levels were similar in both groups. Overall, inhibin B levels correlated significantly positively with blood lead levels and sperm concentration while it was negatively correlated with serum FSH. In multiple regression analysis of data from all participants, blood lead and serum FSH (p < 0.0001 for both) followed by sperm count (p = 0.007) were selected as the only independent variables for inhibin B with an R-adjusted coefficient of determination of 0.3714. The results of the present study suggest that the exposure of the cells of Sertoli to excessive amounts of lead results in inappropriate inhibin B overproduction that may be involved in the impairment of spermatogenesis.
authors.affiliation: Andrology unit, Department of Endocrinology, University Hospital Ghent, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Mahmoud
authors.forename: P
authors.initials: P
authors.lastname: Kiss
authors.forename: M
authors.initials: M
authors.lastname: Vanhoorne
authors.forename: D
authors.initials: D
authors.lastname: De Bacquer
authors.forename: F
authors.initials: F
authors.lastname: Comhaire
mesh_terms: D000328:Adult; D001530:Belgium; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005298:Fertility / Q000187:drug effects*; D006801:Humans; D007265:Inhibins / Q000096:biosynthesis / Q000502:physiology*; D007854:Lead / Q000097:blood / Q000633:toxicity*; D007855:Lead Poisoning; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D012044:Regression Analysis; D012098:Reproduction / Q000187:drug effects*; D012708:Sertoli Cells / Q000187:drug effects; D013076:Sperm Count; D013091:Spermatogenesis / Q000187:drug effects*
chemical_list: C422364:inhibin B; D007854:Lead; D007265:Inhibins