Double feature at the signalplex.
In this issue of Molecular Pharmacology, Oliveras-Reyes et al. (p. 356) describe the agonist-stimulated formation of a caveolin-dependent signalplex that includes both the angiotensin AT(1) receptor and the epidermal growth factor receptor, and probably also a number of other signal transduction intermediates. The signalplex is thought to facilitate the action of protein kinases that mediate angiotensin II-induced transactivation of the epidermal growth factor receptor and activation of extracellular signal-regulated kinase, and epidermal growth factor-induced inositol phosphate accumulation and phosphorylation/desensitization of the AT(1) receptor. This work contributes to an emerging view of the complexity and nonlinearity of signaling via G protein-coupled receptors and receptor tyrosine kinases, and of the importance of membrane compartmentalization to signal transduction.
Neve
Kim A
KA
VA Medical Center (R&D-30), 3710 SW US Veterans Hospital Rd, Portland, OR 97239-2999, USA. nevek@ohsu.edu
D000818:Animals; D022461:Caveolins / Q000737:chemistry / Q000502:physiology; D066246:ErbB Receptors / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D044140:Receptor, Angiotensin, Type 1 / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D022461:Caveolins; D044140:Receptor, Angiotensin, Type 1; D066246:ErbB Receptors