Gene therapy of pituitary diseases.
Despite a stuttering course, gene therapy continues to provide a potential treatment avenue for many human diseases, including cancer and various inherited disorders. Gene therapy is also attractive for the treatment of local, benign disorders, such as pituitary adenomas. Advances in technology have focused on modifying existing viral vectors and developing targeted expression of therapeutic genes in an effort to achieve efficacy with minimal toxicity. Gene therapy also offers innovative strategies for treating hypopituitarism by replacing hormones such as growth hormone (GH) and vasopressin.
Lee
Eun Jig
EJ
Endocrinology, Metabolism, and Molecular Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Jameson
J Larry
JL
D000236:Adenoma / Q000628:therapy; D000818:Animals; D018390:Gene Targeting; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors / Q000008:administration & dosage; D013006:Growth Hormone / Q000235:genetics*; D020249:Hormone Replacement Therapy / Q000379:methods*; D006801:Humans; D007018:Hypopituitarism / Q000628:therapy; D023421:Models, Animal; D010900:Pituitary Diseases / Q000628:therapy*; D010911:Pituitary Neoplasms / Q000628:therapy; D014667:Vasopressins / Q000235:genetics*
D014667:Vasopressins; D013006:Growth Hormone