title: Multicentric reticulohistiocytosis presenting with papulonodular skin eruption and polyarthritis.
abstract: Multicentric reticulohistiocytosis is a rare multisystem disease, presenting with skin lesions and erosive polyarthritis, which is often associated with malignancy. A 2 year untreated natural course of multicentric reticulohistiocytosis, in which the typical nodular skin manifestation of the disease and polyarticular arthritis was present, is described in a 34-year-old lady with no history of major medical disease. Histopathology showed the characteristic histiocytic and multinucleated giant cell infiltrate with ground glass cytoplasm. Massive destruction of articular surfaces and new papular skin lesions accompanied by atrophic scars of previous skin lesions developed after 2 years of untreated active disease.
authors.affiliation: Hormozgan University of Medical Sciences, Bandar Abbas Medical School, Department of Dermatology, PO Box 79145-3654, Bandar Abbas, Iran. sbaghestani@yahoo.com
authors.forename: Shahram
authors.initials: S
authors.lastname: Baghestani
authors.forename: Farrokh
authors.initials: F
authors.lastname: Khosravi
authors.forename: Mohsen
authors.initials: M
authors.lastname: Dehghani Zahedani
authors.forename: Abdol-Ali
authors.initials: AA
authors.lastname: Mahboobi
mesh_terms: D000328:Adult; D001168:Arthritis / Q000175:diagnosis* / Q000188:drug therapy; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D015616:Histiocytosis, Non-Langerhans-Cell / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging / Q000379:methods; D018570:Risk Assessment; D012720:Severity of Illness Index; D012872:Skin Diseases, Vesiculobullous / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*