title: [Impaired endothelium-dependent vasodilation and arterial elasticity in patients with coronary artery disease].
abstract: OBJECTIVE
  To investigate the change in endothelium-dependent vasodilation and arterial elasticity and the association between them in patients with coronary artery disease (CAD).
  
  
  METHODS
  Thirty patients with CAD and thirty control subjects were recruited for this study. Flow-mediated dilation (FMD) in the brachial artery was evaluated by ultrasound Doppler flow method. They also underwent a non-invasive assessment of C(1) large artery and C(2) small artery indices by using pulse wave analysis.
  
  
  RESULTS
  FMD was significantly reduced in CAD group compared with that in control group [(5.17 +/- 2.13)% vs (11.1 +/- 4.36)%, P < 0.05], C(1) large artery elasticity index was similar between the two groups [(11.59 +/- 4.56) ml/mm Hg x 10 vs (12.11 +/- 3.82) ml/mm Hg x 10, P > 0.05]. However, C(2) small artery elasticity index was significantly reduced in CAD group compared with that in control group [(4.20 +/- 1.80) ml/mm Hg x 100 vs (6.26 +/- 2.36) ml/mm Hg x 100, P < 0.05]. There was a positive association between reduced C(2) small artery elasticity index and impaired FMD (r = 0.53, P < 0.05).
  
  
  CONCLUSIONS
  There were impaired endothelium-dependent vasodilation and reduced C(2) small artery elasticity index in the patients with CAD, which were closely correlated with each other. The present study suggested that the measurement of C(2) small artery elasticity might be used as a novel index for the determination of endothelial function.
authors.affiliation: Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. taojungz@yahoo.com
authors.forename: Jun
authors.initials: J
authors.lastname: Tao
authors.forename: Chang
authors.initials: C
authors.lastname: Tu
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
authors.forename: Dong-Hong
authors.initials: DH
authors.lastname: Liu
authors.forename: Ming-Guo
authors.initials: MG
authors.lastname: Xu
authors.forename: Hao-Mei
authors.initials: HM
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Qun-Ying
authors.initials: QY
authors.lastname: Zeng
authors.forename: Guo-Wei
authors.initials: GW
authors.lastname: Chen
mesh_terms: D000368:Aged; D001158:Arteries / Q000503:physiopathology*; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000503:physiopathology*; D004548:Elasticity; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014664:Vasodilation / Q000502:physiology