Successful hormone treatment of orbital leiomyoma.
OBJECTIVE
To describe the successful hormone treatment of noncircumscribed orbital leiomyoma.


METHODS
Case report.


METHODS
A 66-year-old woman with histologically proven orbital leiomyoma.


METHODS
Because surgical excision of the tumor was impossible, therapy with the gonadotropin-releasing hormone (GnRH) analog goserelin was performed.


RESULTS
Hormone treatment was well tolerated and no side effects were noted. The tumor regressed significantly during treatment. No recurrence occurred during a 5-year follow-up period.


CONCLUSIONS
This report describes for the first time successful hormone treatment of a noncircumscribed orbital leiomyoma. Goserelin may have an antiproliferative effect on leiomyoma cells via membrane receptors for GnRH.
Wrede
Julia
J
Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany.
Helmke
Burkhard
B
Hartmann
Marius
M
Voelcker
Hans E
HE
Dithmar
Stefan
S
D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D017273:Goserelin / Q000627:therapeutic use*; D006801:Humans; D007889:Leiomyoma / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D009918:Orbital Neoplasms / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology
D018931:Antineoplastic Agents, Hormonal; D014408:Biomarkers, Tumor; D017273:Goserelin