Cell differentiation inducers derived from thalidomide.
5-Hydroxy- and 4-amino-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione (5HPP-33 and 4APP-33, respectively) have been shown to possess cell differentiation-inducing activity toward human leukemia cell line HL-60.
Noguchi
Tomomi
T
Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Miyachi
Hiroyuki
H
Katayama
Ryohei
R
Naito
Mikihiko
M
Hashimoto
Yuichi
Y
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D005434:Flow Cytometry; D018922:HL-60 Cells; D006801:Humans; D007211:Indoles; D054833:Isoindoles; D007938:Leukemia / Q000188:drug therapy; D018950:Lipopolysaccharide Receptors / Q000032:analysis; D013329:Structure-Activity Relationship; D013792:Thalidomide / Q000031:analogs & derivatives* / Q000138:chemical synthesis
C501339:2-(2,6-diisopropylphenyl)-5-hydroxy-1H-isoindole-1,3-dione; D000970:Antineoplastic Agents; D007211:Indoles; D054833:Isoindoles; D018950:Lipopolysaccharide Receptors; D013792:Thalidomide