[Phospholipases A in mammalian cells: structure, properties, physiological and pathological role].
Phospholipases A are a diverse group of enzymes, which catalyzes the hydrolysis of the ester bond at the sn-1 and sn-2 positions of glycerophospholipids, forming free fatty acids and lysophospholipids. In normal conditions, these enzymes regulate the turnover of free fatty acids in membrane phospholipids, affecting membrane stability, fluidity, and transport processes. Phospholipase activity is also responsible for the generation of intracellular messengers, including arachidonic acid metabolites. Phospholipases are regulated by many factors including selective phosphorylation, intracellular calcium, and pH. In this review we discuss the relationships of phospholipases A1 and A2, their structure, biological function, and implications in various human diseases.
Sadurska
Bozenna
B
Katedra i Zakład Biochemii Akademii Medycznej, Warsaw. sadurska@amwaw.edu.pl
Szumiło
Maria
M
D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology; D010741:Phospholipases A / Q000737:chemistry* / Q000378:metabolism*
D010741:Phospholipases A