title: Selective H3 receptor (H3R) blockade: broad efficacy in cognition and schizophrenia.
authors.affiliation: Neuroscience Research, Abbott Laboratories, AP9A, Global Pharmaceutical Research and Development, Abbott Park, Illinois 60064, USA. gerard.b.fox@abbott.com
authors.forename: G B
authors.initials: GB
authors.lastname: Fox
authors.forename: T A
authors.initials: TA
authors.lastname: Esbenshade
authors.forename: J B
authors.initials: JB
authors.lastname: Pan
authors.forename: K E
authors.initials: KE
authors.lastname: Browman
authors.forename: M
authors.initials: M
authors.lastname: Zhang
authors.forename: M E
authors.initials: ME
authors.lastname: Ballard
authors.forename: R J
authors.initials: RJ
authors.lastname: Radek
authors.forename: H
authors.initials: H
authors.lastname: Miner
authors.forename: R S
authors.initials: RS
authors.lastname: Bitner
authors.forename: K M
authors.initials: KM
authors.lastname: Krueger
authors.forename: B B
authors.initials: BB
authors.lastname: Yao
authors.forename: R
authors.initials: R
authors.lastname: Faghih
authors.forename: L E
authors.initials: LE
authors.lastname: Rueter
authors.forename: V A
authors.initials: VA
authors.lastname: Komater
authors.forename: K U
authors.initials: KU
authors.lastname: Drescher
authors.forename: M J
authors.initials: MJ
authors.lastname: Buckley
authors.forename: J P
authors.initials: JP
authors.lastname: Sullivan
authors.forename: M D
authors.initials: MD
authors.lastname: Cowart
authors.forename: M W
authors.initials: MW
authors.lastname: Decker
authors.forename: A A
authors.initials: AA
authors.lastname: Hancock
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000494:pharmacology* / Q000627:therapeutic use; D003071:Cognition / Q000187:drug effects* / Q000502:physiology; D006633:Histamine Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D008568:Memory / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008811:Mice, Inbred DBA; D023421:Models, Animal; D011759:Pyrrolidines / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D018100:Receptors, Histamine H3 / Q000378:metabolism*; D012559:Schizophrenia / Q000188:drug therapy* / Q000378:metabolism*
chemical_list: D001572:Benzofurans; D006633:Histamine Antagonists; D011759:Pyrrolidines; D018100:Receptors, Histamine H3; C496397:benzonitrile, 4-(2-(2-((2r)-2-methyl-1-pyrrolidinyl)ethyl)-5-benzofuranyl)-