Generating novel polyene antifungal drugs.
In this issue of Chemistry & Biology, Francisco Malpartida and colleagues [1] report the formation of novel polyene amide derivatives upon transformation of the producer strain with SCP2*-derived vectors carrying the erythromycin resistance gene ermE. This unexpected finding provides a new tool for generating antifungal drugs by biotransformation.
Aparicio
Jesús F
JF
Instituto de Biotecnología INBIOTEC, Parque Científico de León y Area de Microbiología, Facultad de Biología, Universidad de León, 24071 León, Spain.
D000935:Antifungal Agents / Q000302:isolation & purification* / Q000378:metabolism; D015195:Drug Design; D018942:Macrolides / Q000302:isolation & purification*; D008780:Methyltransferases / Q000235:genetics; D009005:Monosaccharides / Q000096:biosynthesis / Q000302:isolation & purification*; D011090:Polyenes / Q000302:isolation & purification / Q000378:metabolism; D048630:Polyketide Synthases; D013302:Streptomyces / Q000378:metabolism
D000935:Antifungal Agents; C485858:CE-108; D018942:Macrolides; D009005:Monosaccharides; D011090:Polyenes; C003273:rimocidin; D048630:Polyketide Synthases; D008780:Methyltransferases; C035181:rRNA (adenosine-O-2'-)methyltransferase