title: Effect of pravastatin on cerebral infarcts and white matter lesions.
abstract: The authors examined the effect of pravastatin 40 mg daily on the progression of ischemic brain lesions using repeated brain MRI. After a mean treatment period of 33 months, there was an increase in total ischemic lesion load of 1.1 cm3 (p < 0.001) in the 270 placebo-treated subjects and 1.1 cm3 (p < 0.001) in the 265 pravastatin-treated subjects. There was no difference between the two treatment groups (p = 0.73).
authors.affiliation: Department of Internal Medicine, Leiden University Medical Center, The Netherlands. V.H.ten_Dam@lumc.nl
authors.forename: V H
authors.initials: VH
authors.lastname: ten Dam
authors.forename: D M J
authors.initials: DM
authors.lastname: van den Heuvel
authors.forename: M A
authors.initials: MA
authors.lastname: van Buchem
authors.forename: R G J
authors.initials: RG
authors.lastname: Westendorp
authors.forename: E L E M
authors.initials: EL
authors.lastname: Bollen
authors.forename: I
authors.initials: I
authors.lastname: Ford
authors.forename: A J M
authors.initials: AJ
authors.lastname: de Craen
authors.forename: G J
authors.initials: GJ
authors.lastname: Blauw
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002544:Cerebral Infarction / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects; D018450:Disease Progression; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology; D002537:Intracranial Arteriosclerosis / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control; D008279:Magnetic Resonance Imaging; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000187:drug effects* / Q000473:pathology; D017035:Pravastatin / Q000008:administration & dosage*; D011446:Prospective Studies; D013687:Telencephalon / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D017211:Treatment Failure
chemical_list: D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D017035:Pravastatin