Synthesis and some pharmacological properties of 3-(piperidin-4-yl)-4-substituted-D2-1,2,4-triazoline-5-thione derivatives.
Synthesis of 3-(piperidin-4-yl)-4-substituted-D-2-1,2,4-triazoline-5-thione derivatives, AS-1-AS-4 is described. Results of a preliminary pharmacological screening of two compounds AS-1 and AS-3 are presented.
Dobosz
Maria
M
Department of Organic Chemistry, Skubiszewski Medical University of Lublin, 6 Staszica Str., 20 - 081 Lublin, Poland.
Siwek
Agata
A
Chodkowska
Anna
A
Jagiełło-Wójtowicz
Ewa
E
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D008297:Male; D051379:Mice; D010147:Pain Measurement; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects; D012890:Sleep / Q000187:drug effects; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
D000700:Analgesics; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D002491:Central Nervous System Agents; D007202:Indicators and Reagents; D010880:Piperidines; D013844:Thiazoles; D006916:5-Hydroxytryptophan