[Effect of alpha-tocopherol on apoptosis and necrosis of rat thymocytes induced by calcium ionophore A23187 in various concentrations].
It has been established that alpha-tocopherol prevented rat thymocytes apoptotic death induced by low concentration (250 nM) of calcium ionophore A23187. When necrotic cell death was induced high concentration (10 microM) of calcium ionophore A23187 alpha-tocopherol was able to alter necrosis to apoptosis. It was proposed that such effect can be explained by the ability of alpha-tocopherol to prevent the mitochondrial permeability transition--a key event in apoptosis and necrosis induction.
Petrova
G V
GV
Donchenko
G V
GV
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D000001:Calcimycin / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D007476:Ionophores / Q000494:pharmacology*; D008297:Male; D009336:Necrosis; D051381:Rats; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects* / Q000473:pathology; D024502:alpha-Tocopherol / Q000494:pharmacology*
D007476:Ionophores; D000001:Calcimycin; D024502:alpha-Tocopherol; D002118:Calcium