title: [Significance of MMP2 and MMP9 expression in prostate cancer].
abstract: OBJECTIVE
  To evaluate the significance of the expression of matrix metalloproteinases (MMPs) in prostate cancer (PCa) and its clinical association.
  
  
  METHODS
  Fifty one cases of PCa and 10 cases of BPH were studied by immunohistochemical method using monoclonal antibodies to MMP2 and MMP9.
  
  
  RESULTS
  There was significant correlation between MMP2 or MMP9 and pathological grade, Gleason score and PCa metastasis.
  
  
  CONCLUSIONS
  The expression of MMP2 and MMP9 may play an important role in the development and metastasis of PCa.
authors.affiliation: Department of Urology, China PLA General Hospital, Beijing 100853, China. doctorzhxy@163.com
authors.forename: Xiao-Yi
authors.initials: XY
authors.lastname: Zhang
authors.forename: Bao-Fa
authors.initials: BF
authors.lastname: Hong
authors.forename: Guang-Fu
authors.initials: GF
authors.lastname: Chen
authors.forename: Ya-Li
authors.initials: YL
authors.lastname: Lu
authors.forename: Mei
authors.initials: M
authors.lastname: Zhong
mesh_terms: D000368:Aged; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis*; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9