title: Designing a neural network for the constraint optimization of the fitness functions devised based on the load minimization of the genetic code.
abstract: Nonrandom patterns in codon assignments are supported by many statistical and biochemical studies in the last two decades. The canonical genetic code is known to be highly efficient in minimizing the effects of mistranslational errors and point mutations, an ability, which in term is designated "load minimization". Prior studies have included many attempts at quantitative estimation of the fraction of randomly generated codes, which in terms of load minimization, score higher than the canonical genetic code. In this study, a neural network, which estimates a highly optimized genetic code in a relatively short period of time has been devised. Several fitness functions were used throughout this text. Meanwhile, we have made use of two cost measure matrices, PAM74-100 and mutation matrix.
authors.affiliation: Department of Biotechnology, Faculty of Science, University of Tehran, Enghelab St., Tehran, Iran. lucipherase@eml.cc
authors.forename: Hani
authors.initials: H
authors.lastname: Goodarzi
authors.forename: Hamed Shateri
authors.initials: HS
authors.lastname: Najafabadi
authors.forename: Noorossadat
authors.initials: N
authors.lastname: Torabi
mesh_terms: D000465:Algorithms; D000818:Animals; D001185:Artificial Intelligence; D018389:Codon, Nonsense; D019295:Computational Biology; D003198:Computer Simulation; D019143:Evolution, Molecular; D005815:Genetic Code; D006801:Humans; D008957:Models, Genetic; D008958:Models, Molecular; D015233:Models, Statistical; D009154:Mutation; D020125:Mutation, Missense; D016571:Neural Networks, Computer; D009474:Neurons / Q000378:metabolism; D012984:Software; D049490:Systems Biology
chemical_list: D018389:Codon, Nonsense