title: Expression of p53 protein and primary tumour volume in patients with nasopharyngeal carcinoma.
abstract: OBJECTIVE
  To investigate the relationship of p53 protein expression and primary tumour volume in patients with nasopharyngeal carcinoma.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Tertiary care centre.
  
  
  METHODS
  Forty-two newly diagnosed patients participated in the study.
  
  
  METHODS
  The relationship between p53 status, TNM stage, and computed tomography-derived primary tumour volume.
  
  
  RESULTS
  In patients with high p53 stains, the tumour volume was larger (p = .03). p53 was found to be independent of clinical stage (p = .84).
  
  
  CONCLUSIONS
  There is a positive correlation between primary tumour volume and p53 status.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, 135 Nanhsiau Street, Changhua 500, Taiwan.
authors.forename: Mu-Kuan
authors.initials: MK
authors.lastname: Chen
authors.forename: Hong-Shen
authors.initials: HS
authors.lastname: Lee
authors.forename: Julia H
authors.initials: JH
authors.lastname: Chang
authors.forename: Cheng-Chuan
authors.initials: CC
authors.lastname: Chang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000235:genetics / Q000473:pathology*; D004396:Coloring Agents; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000235:genetics / Q000473:pathology*; D009367:Neoplasm Staging; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods; D016159:Tumor Suppressor Protein p53 / Q000032:analysis* / Q000235:genetics
chemical_list: D004396:Coloring Agents; D016159:Tumor Suppressor Protein p53