MicroRNAs: all gone and then what?
MicroRNAs are abundant gene regulatory factors whose function in animal development and homeostasis is poorly understood. A new study reports the genetic elimination of miRNA function on a full genomic scale and identifies a subfamily of miRNAs involved in brain morphogenesis.
Hobert
Oliver
O
Department of Biochemistry and Molecular Physics, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA. or38@columbia.edu
D000818:Animals; D001921:Brain / Q000196:embryology* / Q000378:metabolism; D002454:Cell Differentiation; D018507:Gene Expression Regulation, Developmental; D035683:MicroRNAs / Q000502:physiology*; D009024:Morphogenesis / Q000235:genetics*; D009420:Nervous System / Q000196:embryology / Q000378:metabolism; D043244:Ribonuclease III / Q000378:metabolism*
D035683:MicroRNAs; D043244:Ribonuclease III