title: Cutaneous squamous carcinoma in situ (Bowen's disease): treatment with Mohs micrographic surgery.
abstract: BACKGROUND
  Bowen's disease (BD), also known as squamous intraepidermal carcinoma, is a malignant skin tumor with a potential to progress to invasive carcinoma.
  
  
  OBJECTIVE
  We sought to report a large series of patients with BD treated with Mohs micrographic surgery (MMS).
  
  
  METHODS
  This prospective, multicenter, case series included all patients in Australia treated with MMS for BD, who were monitored by the Skin and Cancer Foundation between 1993 and 2002.
  
  
  RESULTS
  There were 270 cases; the majority (93.4%) were located in the head and neck area. In 50.7% of cases it was a recurrent tumor. In 20% the tumor was initially misdiagnosed as basal cell carcinoma or squamous cell carcinoma. No cases with perineural invasion were diagnosed. There were 6 cases of recurrence (6.3%) of 95 patients who completed a 5-year follow-up period after MMS.
  
  
  CONCLUSIONS
  The low 5-year recurrence rate of BD with MMS emphasizes the importance of margin-controlled excision, especially in the head and neck area where tissue preservation is essential.
authors.affiliation: Oculoplastic and Orbital Division, Department of Ophthalmology and Visual Sciences, Royal Adelaide Hospital, University of Adelaide, Adelaide, Australia.
authors.forename: Igal
authors.initials: I
authors.lastname: Leibovitch
authors.forename: Shyamala C
authors.initials: SC
authors.lastname: Huilgol
authors.forename: Dinesh
authors.initials: D
authors.lastname: Selva
authors.forename: Shawn
authors.initials: S
authors.lastname: Richards
authors.forename: Robert
authors.initials: R
authors.lastname: Paver
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001913:Bowen's Disease / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015580:Mohs Surgery; D011446:Prospective Studies; D012878:Skin Neoplasms / Q000601:surgery*