title: Glaciapyrroles A, B, and C, pyrrolosesquiterpenes from a Streptomyces sp. isolated from an Alaskan marine sediment.
abstract: A Streptomyces sp. (NPS008187) isolated from a marine sediment collected in Alaska was found to produce three new pyrrolosesquiterpenes, glyciapyrroles A (1), B (2), and C (3), along with the known diketopiperazines cyclo(leucyl-prolyl) (4), cyclo(isoleucyl-prolyl) (5), and cyclo(phenylalanyl-prolyl) (6). The structures of 1, 2, and 3 were established using spectroscopic methods.
authors.affiliation: Nereus Pharmaceuticals, Inc., 10480 Wateridge Circle, San Diego, California 92121, USA.
authors.forename: Venkat R
authors.initials: VR
authors.lastname: Macherla
authors.forename: Jehnan
authors.initials: J
authors.lastname: Liu
authors.forename: Christopher
authors.initials: C
authors.lastname: Bellows
authors.forename: Sy
authors.initials: S
authors.lastname: Teisan
authors.forename: Benjamin
authors.initials: B
authors.lastname: Nicholson
authors.forename: Kin S
authors.initials: KS
authors.lastname: Lam
authors.forename: Barbara C M
authors.initials: BC
authors.lastname: Potts
mesh_terms: D000413:Alaska; D019015:Geologic Sediments; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D010456:Peptides, Cyclic; D011758:Pyrroles; D012717:Sesquiterpenes; C501803:glaciapyrrole A; C501804:glaciapyrrole B; C501805:glaciapyrrole C