title: Metastatic clear cell variant of hepatocellular carcinoma with an occult hepatic primary.
abstract: Metastatic clear cell carcinomas are commonly seen in the kidney and lung. Clear cell variant of hepatocellular carcinoma is an uncommon tumour. Diagnosis is usually made by correlation of histopathology, tumour markers and immunohistochemistry, especially HepPar 1. In this unusual case of metastatic clear cell carcinoma presenting as Sister Mary Joseph's nodule, no primary evidence was observed radiologically in the liver, but the level of alfa fetoprotein was markedly elevated. Metastatic clear cell carcinoma of the liver with an occult hepatic primary was diagnosed by immunohistochemical profile of the tumour.
authors.affiliation: Tata Memorial Hospital, Parel, Mumbai 400012, India.
authors.forename: Samir
authors.initials: S
authors.lastname: Shah
authors.forename: Sudeep
authors.initials: S
authors.lastname: Gupta
authors.forename: Tanuja
authors.initials: T
authors.lastname: Shet
authors.forename: Amita
authors.initials: A
authors.lastname: Maheshwari
authors.forename: Rekha
authors.initials: R
authors.lastname: Wuntkal
authors.forename: Kunisshery Mallath
authors.initials: KM
authors.lastname: Mohandas
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000188:drug therapy / Q000473:pathology*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001707:Biopsy, Needle; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000473:pathology*; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000473:pathology* / Q000601:surgery; D018570:Risk Assessment; D016896:Treatment Outcome; D000509:alpha-Fetoproteins / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; D000509:alpha-Fetoproteins