[Nonoperative ablation for liver metastases. Possibilities and limitations as a curative treatment].
Under the term "nonoperative ablation" are grouped a number of heterogeneous approaches for the treatment of liver metastases, including laser-induced thermotherapy (LITT), radio-frequency therapy (RF), and cryotherapy. In general these procedures had been intended only for palliative purposes. The establishment of clinically relevant lesion size and a lack of long-term survival data were regarded as main limitations to using them with curative intention. During the last years however, new application systems have demonstrated remarkable results in RF and LITT, and some clinical studies have shown long-term survival in selected patients comparable to that for hepatic resection. We review possibilities and limitations of nonoperative ablation procedures with curative intent, highlighting the histopathological bases of thermal ablation techniques and clinical aspects such as R0 ablation and long-term survival.
Germer
C-T
CT
Klinik für Allgemein-, Visceral- und Thoraxchirurgie, Klinikum Nürnberg Nord, Nürnberg. germer@klinikum-neurnberg.de
Buhr
H J
HJ
Isbert
C
C
D000818:Animals; D002470:Cell Survival; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D017679:Cryotherapy / Q000295:instrumentation / Q000379:methods; D018572:Disease-Free Survival; D004867:Equipment Design; D006498:Hepatectomy; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D008114:Liver Neoplasms, Experimental / Q000473:pathology / Q000628:therapy; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy; D010166:Palliative Care / Q000379:methods*; D011817:Rabbits