title: Microdamage in bone: surface analysis and radiological detection.
abstract: Microdamage accumulation leads to reduced bone strength and fracture. Intact, damaged and Rose Bengal stained cortical bone specimens were studied using SEM and EDXA imaging. SEM coupled with EDXA studies showed selective labelling of surface damage due to binding of dye at free lattice sites. A series of novel iodinated X-ray contrast agent were synthesised. These agents demonstrated excellent stability, water solubility and lack of atropisomerism. Preliminary imaging studies, using cone-beam mu-CT, demonstrated their ability to provide visible contrast in the solid state on bone surfaces.
authors.affiliation: Department of Chemistry, Trinity College, Dublin, Ireland.
authors.forename: Raman
authors.initials: R
authors.lastname: Parkesh
authors.forename: T
authors.initials: T
authors.lastname: Clive Lee
authors.forename: Thorfinnur
authors.initials: T
authors.lastname: Gunnlaugsson
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Gowin
mesh_terms: D015502:Absorptiometry, Photon; D000818:Animals; D015519:Bone Density; D016723:Bone Remodeling; D002417:Cattle; D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D050723:Fractures, Bone / Q000000981:diagnostic imaging*; D007455:Iodine / Q000737:chemistry / Q000494:pharmacology*; D011877:Radionuclide Imaging; D013314:Stress, Mechanical
chemical_list: D003287:Contrast Media; D007455:Iodine