Genetic variability in the RAGE gene: possible implications for nutrigenetics, nutrigenomics, and understanding the susceptibility to diabetic complications.
Complex chemical processes called nonenzymatic glycation and glycoxidation are one of the interesting examples of potentially harmful interaction between nutrition and disease. This review summarizes factors influencing the extent of glycoxidation in health and disease and especially focuses on the role of genetic variability in "glycoxidation-related genes" in a disease and diet-related pathogenesis. Possible interaction between genetic variability in relevant loci and dietary advanced glycation end products (AGEs) is considered. As AGEs possess a wide range of chemical and biological effects, the interindividual functional variability in systems dealing with glycoxidation could have a significant nutrigenomic and nutrigenetic consequences.
Kanková
Katerina
K
Department of Clinical and Experimental Pharmacotherapy, Slovak Medical University, Institute of Preventive and Clinical Medicine, Bratislava, Slovakia. kankov@med.muni.cz
Sebeková
Katarína
K
D048909:Diabetes Complications / Q000235:genetics*; D004032:Diet; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation; D017127:Glycation End Products, Advanced / Q000097:blood / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D009747:Nutritional Physiological Phenomena; D010084:Oxidation-Reduction; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000235:genetics*
D017127:Glycation End Products, Advanced; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic