Soluble adhesion molecules and marine n-3 fatty acids in patients referred for coronary angiography.
OBJECTIVE
To investigate the relationship between soluble cellular adhesion molecules (sCAMs) and the extent of coronary artery disease (CAD) in patients with stable angina pectoris.


RESULTS
Two hundred and ninety-one subjects had fasting levels of circulating intercellular adhesion molecule-1(sICAM-1), vascular cellular adhesion molecule-1 (sVCAM-1), sP-selectin and contents of n-3 polyunsaturated fatty acids (n-3 PUFA) in granulocyte membranes and adipose tissue determined before undergoing elective coronary angiography. Levels of soluble VCAM-1 (983+/-216 versus 893+/-196 ng/l, p<0.001), ICAM-1 (318+/-140 versus 290+/-75 ng/l, p<0.05) and P-selectin (90+/-27 versus 80+/-23 ng/l, p<0.01) were significantly increased in subjects with significant CAD compared to subjects with no significant stenoses. In a linear regression analysis, both sVCAM-1 and sP-selectin, but not sICAM-1, correlated to the presence and the severity of CAD. Both sICAM-1 and sP-selectin were significantly correlated to current smoking status and a history of myocardial infarction. The content of total n-3 PUFA and docosahexaenoic acid in adipose tissue was marginally, but significant positively correlated to VCAM-1.


CONCLUSIONS
sVCAM-1 and sP-selectin may serve as markers of CAD in patients with stable angina pectoris. Only sVCAM-1 was weakly correlated to n-3 PUFA in adipose tissue.
Eschen
Ole
O
Center for Cardiovascular Research, Department of Cardiology, Aalborg Sygehus, Aarhus University Hospital, Aalborg, Denmark. oe@dadlnet.dk
Christensen
Jeppe Hagstrup
JH
Toft
Egon
E
Schmidt
Erik Berg
EB
D000273:Adipose Tissue / Q000737:chemistry; D000787:Angina Pectoris / Q000503:physiopathology*; D015415:Biomarkers / Q000032:analysis*; D015331:Cohort Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000473:pathology*; D005227:Fatty Acids / Q000032:analysis*; D005260:Female; D005395:Fish Oils; D006098:Granulocytes; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000032:analysis*; D012720:Severity of Illness Index; D019010:Vascular Cell Adhesion Molecule-1 / Q000032:analysis*
D015415:Biomarkers; D005227:Fatty Acids; D005395:Fish Oils; D019007:P-Selectin; D019010:Vascular Cell Adhesion Molecule-1