Successful treatment with miltefosine of disseminated cutaneous leishmaniasis in a severely immunocompromised patient infected with HIV-1.
We describe here a case of disseminated cutaneous leishmaniasis due to Leishmania major in a severely immunocompromised patient from Burkino Faso, Africa, who is infected with human immunodeficiency virus-1. The skin lesions failed to respond to full treatment courses of amphotericin B, sodium stibogluconate, and liposomal amphotericin B but were successfully treated with miltefosine, an alkylphosphocholine analogue.
Schraner
Christine
C
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
Hasse
Barbara
B
Hasse
Urs
U
Baumann
Doris
D
Faeh
Anja
A
Burg
Günther
G
Grimm
Felix
F
Mathis
Alex
A
Weber
Rainer
R
Günthard
Huldrych F
HF
D000328:Adult; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D016867:Immunocompromised Host; D016774:Leishmaniasis, Diffuse Cutaneous / Q000188:drug therapy* / Q000209:etiology*; D008297:Male; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012867:Skin / Q000473:pathology
D000981:Antiprotozoal Agents; D010767:Phosphorylcholine; C039128:miltefosine