New inhibitors of rabbit muscle triose-phosphate isomerase.
We describe the synthesis and evaluation of three new competitive inhibitors of triose-phosphate isomerase. One of them (phosphoglycoloamidoxime: K(i) = 4.5 microM) is among the best reversible inhibitors so far reported for this enzyme.
Fonvielle
M
M
LCBB, ICMMO, Bat. 420, Université Paris-Sud, Orsay, France.
Mariano
S
S
Therisod
M
M
D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000201:enzymology; D011817:Rabbits; D014305:Triose-Phosphate Isomerase / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D014305:Triose-Phosphate Isomerase