title: Safety and immunogenicity of the intradermal Thai red cross (2-2-2-0-1-1) post exposure vaccination regimen in the Indian population using purified chick embryo cell rabies vaccine.
abstract: OBJECTIVE
  To test the immunogenicity of the WHO recommended "2-2-2-0-1-1" post-exposure rabies vaccination regimen in Indian subjects to determine the feasibility of replacing crude sheep brain nerve tissue rabies vaccine with modern tissue culture rabies vaccine at major anti-rabies treatment centers throughout India.
  
  
  METHODS
  Purified chick embryo cell vaccine (PCECV) was administered in the dosage of 0.1 mL per site to 53 Indian subjects.
  
  
  RESULTS
  All subjects produced rabies antibodies above 0.5 IU/mL by day 14 post-vaccination. Only minor adverse reactions including swelling (6.6%), erythema (5.4%) and pain (1.4%) were observed for which no treatment was required.
  
  
  CONCLUSIONS
  This study demonstrated that PCECV is safe and highly immunogenic in Indian subjects when administered intradermally as 0.1 mL/site using the "2-2-2-0-1-1" post-exposure regimen.
authors.affiliation: National Institute of Communicable Diseases, Sham Nath Marg, New Delhi 110 054, India. malachhabra@yahoo.co.in
authors.forename: Mala
authors.initials: M
authors.lastname: Chhabra
authors.forename: R L
authors.initials: RL
authors.lastname: Ichhpujani
authors.forename: M
authors.initials: M
authors.lastname: Bhardwaj
authors.forename: K N
authors.initials: KN
authors.lastname: Tiwari
authors.forename: R C
authors.initials: RC
authors.lastname: Panda
authors.forename: S
authors.initials: S
authors.lastname: Lal
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D002642:Chick Embryo; D006801:Humans; D007115:Immunization Schedule; D007136:Immunoglobulins / Q000032:analysis; D007194:India; D007271:Injections, Intradermal; D011818:Rabies / Q000276:immunology* / Q000517:prevention & control*; D011819:Rabies Vaccines / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology*; D012011:Red Cross; D012449:Safety; D013785:Thailand; D014611:Vaccination
chemical_list: D000914:Antibodies, Viral; D007136:Immunoglobulins; D011819:Rabies Vaccines