title: Cytotoxic effects of novel amphiphilic dimers consisting of 5-fluorodeoxyuridine and arabinofuranosylcytosine in cross-resistant H9 human lymphoma cells.
abstract: Various amphiphilic heterodinucleoside phosphates have recently been synthesized in order to overcome drug resistance. These agents contain 5-fluorodeoxyuridine (5-FdUrd) and arabinofuranosylcytosine (Ara-C). We now investigated the action of two of these novel dimers (#2 and #10) in sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells. The dimers were compared with 5-FdUrd and Ara-C for growth inhibition, apoptosis induction, and cell-cycle effects. No significant difference in the cytotoxicity of dimer #2 could be observed between sensitive and 5-FdUrd/Ara-C cross-resistant H9 cells (IC50 values of 220 nM and 200 nM, respectively), indicating that further studies with this compound are warranted.
authors.affiliation: Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
authors.forename: Philipp
authors.initials: P
authors.lastname: Saiko
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Horvath
authors.forename: Christoph
authors.initials: C
authors.lastname: Illmer
authors.forename: Sibylle
authors.initials: S
authors.lastname: Madlener
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Bauer
authors.forename: Thomas
authors.initials: T
authors.lastname: Hoechtl
authors.forename: Natascha
authors.initials: N
authors.lastname: Erlach
authors.forename: Michael
authors.initials: M
authors.lastname: Grusch
authors.forename: Georg
authors.initials: G
authors.lastname: Krupitza
authors.forename: Robert M
authors.initials: RM
authors.lastname: Mader
authors.forename: Walter
authors.initials: W
authors.lastname: Jaeger
authors.forename: Herbert
authors.initials: H
authors.lastname: Schott
authors.forename: Ram P
authors.initials: RP
authors.lastname: Agarwal
authors.forename: Monika
authors.initials: M
authors.lastname: Fritzer-Szekeres
authors.forename: Thomas
authors.initials: T
authors.lastname: Szekeres
mesh_terms: D000970:Antineoplastic Agents / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects*; D003561:Cytarabine / Q000737:chemistry / Q000633:toxicity*; D019281:Dimerization; D005467:Floxuridine / Q000737:chemistry / Q000633:toxicity*; D006801:Humans; D008223:Lymphoma / Q000473:pathology*; D010766:Phosphorylation
chemical_list: D000970:Antineoplastic Agents; D005467:Floxuridine; D003561:Cytarabine