title: Chronic infantile neurological, cutaneous, and articular syndrome with severe early articular manifestations.
abstract: We report an 11-month-old boy of French origin who had chronic, infantile, neurological, cutaneous, and articular syndrome with a particularly severe joint involvement with early onset. The diagnosis was based on the association of neurologic, cutaneous (urticarial skin eruption), and articular manifestations accompanied by recurrent bouts of fever. No mutation of the CIAS1 gene could be identified. Skeletal involvement was particularly severe, leading to considerable limitation of motion.
authors.affiliation: Department of Dermatology, University Hospital, Reims, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Leys
authors.forename: Catherine
authors.initials: C
authors.lastname: Eschard
authors.forename: Jacques
authors.initials: J
authors.lastname: Motte
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Prieur
authors.forename: Bernard
authors.initials: B
authors.lastname: Kalis
authors.forename: Philippe
authors.initials: P
authors.lastname: Bernard
mesh_terms: D000015:Abnormalities, Multiple; D002908:Chronic Disease; D003937:Diagnosis, Differential; D006801:Humans; D007223:Infant; D009139:Musculoskeletal Abnormalities / Q000175:diagnosis*; D020752:Neurocutaneous Syndromes / Q000175:diagnosis*