Developmental toxicity of the angiotensin II type 1 receptor antagonists during human pregnancy: a report of 10 cases.
OBJECTIVE
Angiotensin II type 1 receptor antagonists (ARA). Interacted with the renin-angiotensin system, and the present study was undertaken to examine their fetal and neonatal toxicity when taken by the mother during pregnancy.


METHODS
Prospective follow up of pregnant women exposed to an ARA during early pregnancy.


METHODS
The present study was conducted in the departments of Paedriatric Pharmacology of the University hospital Robert Debre in Paris, France.


METHODS
Ten women exposed to an ARA during early pregnancy.


METHODS
Prospective follow up.


METHODS
Fetal ultrasonography and outcome of pregnancy.


RESULTS
Prenatal ultrasonography showed abnormal features in five cases (oligoamnios related to fetal tabular dysgenesis, fetal dysmorphia and renal abnormalities). Outcome of pregnancy was as follows: three induced abortions, two stillbirths (twin pregnancy), one neonate presenting with dysmorphia and renal disease and five neonates with an uneventful development.


CONCLUSIONS
Women of reproductive age should be advised of the possible hazards of ARA and treatment should be stopped as soon as pregnany has been documented.
Serreau
Raphael
R
Department of Pediatric Pharmacology and Pharmacogenetics, Hôpital Robert Debré, Paris, France.
Luton
Dominique
D
Macher
Marie-Alice
MA
Delezoide
Anne-Lise
AL
Garel
Catherine
C
Jacqz-Aigrain
Evelyne
E
D000014:Abnormalities, Drug-Induced / Q000000981:diagnostic imaging / Q000209:etiology*; D000328:Adult; D047228:Angiotensin II Type 1 Receptor Blockers; D000959:Antihypertensive Agents; D000075202:Contraindications; D005260:Female; D005333:Fetus / Q000002:abnormalities*; D005500:Follow-Up Studies; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000188:drug therapy*; D011247:Pregnancy; D011446:Prospective Studies; D012084:Renin-Angiotensin System / Q000187:drug effects; D013723:Teratogens / Q000633:toxicity*; D016216:Ultrasonography, Prenatal
D047228:Angiotensin II Type 1 Receptor Blockers; D000959:Antihypertensive Agents; D013723:Teratogens