title: [Study on ultra-structural pathological changes of rats poisoned by tetramine].
abstract: OBJECTIVE
  To observe ultra-structural pathological changes of materiality viscera of rats poisoned by different dose of tetramine and to study the toxic mechanism.
  
  
  METHODS
  Acute and subacute tetramine toxicity models were made by oral administration with different dose of tetramine. Brain, heart, liver, spleen and kidney were extracted and observed by electromicroscopic examination.
  
  
  RESULTS
  The injuries of brain cells, cardiocytes and liver cells were induced by different dose of tetramine. These were not obviously different of the injuries of the kindy cells and spleen cells of rats poisoned by different dose of tetramine. Ultra-structural pathological changes were abserved including mitochondria slight swelling and neurolemma's array turbulence in the brain cells, mitochondria swelling or abolish and rupture of muscle fiber in the heart cells, mitochondria swelling and the glycogen decreased in the liver cells.
  
  
  CONCLUSIONS
  The toxic target organs of tetramine are the heart, brain and liver.
authors.affiliation: Department of Medicolegal, Tongji Medical College, Huazhong Science and Technology University, Wuhan 430030, China.
authors.forename: Chuan-hong
authors.initials: CH
authors.lastname: Zhi
authors.forename: Liang
authors.initials: L
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology*; D001952:Bridged-Ring Compounds / Q000506:poisoning*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008099:Liver / Q000473:pathology*; D008297:Male; D046529:Microscopy, Electron, Transmission; D008929:Mitochondria, Heart / Q000473:pathology; D008930:Mitochondria, Liver / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D011041:Poisoning / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001952:Bridged-Ring Compounds; C010349:tetramethylenedisulfotetramine