Familial hypercholesterolemia patients treated with statins at no increased risk for intracranial vascular lesions despite increased cholesterol burden and extracranial atherosclerosis.
OBJECTIVE
To correlate known vascular disease risk factors and the signs of extracranial and intracranial changes of vascular origin in young patients with heterozygous familial hypercholesterolemia (FH).


METHODS
39 DNA test-verified heterozygous FH North Karelian patients (FH-NK), aged 6 to 48, 28 of them treated with statins, and 25 healthy controls underwent brain magnetic resonance imaging (MRI) and carotid ultrasound.


RESULTS
Common carotid intima-media thickness was significantly greater in the patients (P=0.005). MR angiography showed no pathological changes, other than 1 incidental aneurysm. The number and size of white matter hyperintensities on T2-weighted MR images, considered as markers of microvascular alterations, did not differ between patients and controls.


CONCLUSIONS
FH-NK patients treated with statins seem to be at no increased risk for brain infarcts or other brain lesions of vascular origin when younger than age 50.
Soljanlahti
Sami
S
Medical Imaging Center, Helsinki University Central Hospital, Helsinki, Finland. sami.soljanlahti@hus.fi
Autti
Taina
T
Lauerma
Kirsi
K
Raininko
Raili
R
Keto
Pekka
P
Turtola
Hannu
H
Vuorio
Alpo F
AF
D000293:Adolescent; D000328:Adult; D001161:Arteriosclerosis / Q000473:pathology; D050197:Atherosclerosis / Q000150:complications*; D001794:Blood Pressure; D020520:Brain Infarction / Q000175:diagnosis* / Q000473:pathology; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation; D002648:Child; D002784:Cholesterol / Q000378:metabolism*; D006579:Heterozygote; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000473:pathology; D006938:Hyperlipoproteinemia Type II / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D012306:Risk; D012307:Risk Factors; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology; D014463:Ultrasonography
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002784:Cholesterol