title: Acute pancreatitis associated with combined lisinopril and atorvastatin therapy.
abstract: Few data exist about the incidence of drug-induced pancreatitis in the general population. Drugs are related to the etiology of pancreatitis in about 1.4-2% of cases. Although statins are generally well tolerated, acute pancreatitis has been reported in a few cases treated with atorvastatin, fluvastatin and simvastatin. A 86-year-old man with long-standing history of hypertension and hyperlipidemia, who was treated with lisinopril 10 mg and atorvastatin 20 mg once daily presented with acute pancreatitis. Other causes of the disease were ruled out. After cessation of the drugs, his physical condition improved and the amylase level decreased. To our knowledge, pancreatitis induced by a combination of atorvastatin together with lisinopril has never been reported in the literature.
authors.affiliation: Department of Internal Medicine, Baskent University Faculty of Medicine, Fevzi Cakmak Caddesi, Bahcelievler, Ankara, Turkey. drkanbay@yahoo.com
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kanbay
authors.forename: Haldun
authors.initials: H
authors.lastname: Sekuk
authors.forename: Ugur
authors.initials: U
authors.lastname: Yilmaz
authors.forename: Gürden
authors.initials: G
authors.lastname: Gur
authors.forename: Sedat
authors.initials: S
authors.lastname: Boyacioglu
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D000069059:Atorvastatin; D004347:Drug Interactions; D006538:Heptanoic Acids / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D006801:Humans; D017706:Lisinopril / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D008297:Male; D010195:Pancreatitis / Q000139:chemically induced*; D011758:Pyrroles / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*
chemical_list: D000924:Anticholesteremic Agents; D000959:Antihypertensive Agents; D006538:Heptanoic Acids; D011758:Pyrroles; D000069059:Atorvastatin; D017706:Lisinopril