title: Quantitative changes in thyroid lymphoid cells as a marker of malignancy.
abstract: OBJECTIVE
  To investigate the possibility of using morphometric changes in lymphoid cells in thyroid tissue as a marker of malignant tumors.
  
  
  METHODS
  Morphometry of biopsy material was performed with a semiautomated, computerized image analyzer.
  
  
  RESULTS
  Nine features were selected. These features formed the criteria for differentiation between malignant and benign disease. Equations for the calculation of a weighting coefficient for each feature and a diagnostic index were derived. The values for the diagnostic index for the groups with malignant and benign pathology differed significantly.
  
  
  CONCLUSIONS
  One can determine the presence of a malignant tumor in the thyroid gland from the diagnostic index value.
authors.affiliation: Laboratory for Electron Paramagnetic Resonance-Dosimetry and Cytology, Belarusian State Medical University, 23 Philimonova Street, Room 416, 220114 Minsk, Belarus. kirillov@msmi.minsk.by
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Kirillov
authors.forename: Elena E
authors.initials: EE
authors.lastname: Stebenyaeva
authors.forename: Andrey A
authors.initials: AA
authors.lastname: Paplevka
authors.forename: Evgeny P
authors.initials: EP
authors.lastname: Demidchik
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D006801:Humans; D008214:Lymphocytes / Q000097:blood / Q000473:pathology*; D013961:Thyroid Gland / Q000473:pathology; D013964:Thyroid Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor