Wild-type Rinderpest virus uses SLAM (CD150) as its receptor.
Rinderpest virus (RPV) is a morbillivirus, related closely to the human pathogen Measles virus (MV). Although cell culture-adapted strains of RPV can infect many kinds of cell from different hosts, one such strain has previously been shown to have a detectable preference for cells expressing the MV receptor CD150 (SLAM), a protein found only on certain types of activated T cells, B cells and dendritic cells. Here, it is shown that the wild-type, virulent parent of the most common vaccine strain of RPV requires CD150 as a receptor, whilst the cell culture-adapted vaccine strain has acquired the ability to use heparan sulphate as an alternative receptor.
Baron
Michael D
MD
Institute for Animal Health, Ash Road, Pirbright, Surrey GU24 0NF, UK.
D000222:Adaptation, Physiological; D000818:Animals; D015703:Antigens, CD; D002460:Cell Line; D006224:Cricetinae; D006023:Glycoproteins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics / Q000502:physiology*; D009154:Mutation; D011956:Receptors, Cell Surface; D011991:Receptors, Virus / Q000235:genetics / Q000502:physiology*; D011995:Recombination, Genetic; D012302:Rinderpest virus / Q000502:physiology*; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1; D014779:Virus Replication
D015703:Antigens, CD; D006023:Glycoproteins; D007136:Immunoglobulins; D011956:Receptors, Cell Surface; D011991:Receptors, Virus; C000604059:SLAMF1 protein, human; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1