Epstein-Barr virus-associated familial Hodgkin lymphoma: paediatric onset in three of five siblings.
We report familial Hodgkin lymphoma (FHL) in a family with five children, of which three were human leucocyte antigen (HLA) class I identical. These three siblings were diagnosed with Epstein-Barr virus (EBV)-positive Hodgkin lymphoma within a 6-year period. All three were treated with chemo- and/or radiotherapy and are presently in complete remission. None of the children had evidence of overt immunodeficiency or autoimmune disease. This case contributes to the existing material on FHL and implies a role for both HLA class I antigens and EBV infection of the tumour cell population in the pathogenesis of some cases of FHL.
Kamper
Peter M
PM
Department of Haematology, Aarhus University Hospital, Aarhus, Denmark. rlg05pk@as.aaa.dk
Kjeldsen
Eigil
E
Clausen
Niels
N
Bendix
Knud
K
Hamilton-Dutoit
Stephen
S
d'Amore
Francesco
F
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000032:analysis; D020031:Epstein-Barr Virus Infections / Q000235:genetics* / Q000276:immunology; D005260:Female; D015234:HLA-A Antigens / Q000032:analysis; D015235:HLA-B Antigens / Q000032:analysis; D059945:HLA-B38 Antigen; D004854:Herpesvirus 4, Human / Q000235:genetics; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006689:Hodgkin Disease / Q000235:genetics* / Q000276:immunology / Q000821:virology*; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D010375:Pedigree; D012074:Remission Induction
D004279:DNA, Viral; D015234:HLA-A Antigens; C039683:HLA-A*26 antigen; C037709:HLA-A9 antigen; D015235:HLA-B Antigens; D059945:HLA-B38 Antigen; C035270:HLA-B5 antigen; D015395:Histocompatibility Antigens Class I