Usefulness of bone uptake ratio of bone scintigraphy in hemodialysis patients.
OBJECTIVE
It is important to estimate the bone metabolism in patients with renal osteodystrophy. The methods of estimation must be noninvasive, accurate, and able to measure repeatedly.


METHODS
The regions of interest on bone scintigraphy were drawn over the radius in 22 hemodialysis patients (10 males, 12 females). The bone/soft tissue ratio (B/ST ratio) was calculated for all patients. The bone soft tissue ratio of both skull (S) and radius (R) was obtained from the resultant count ratios. We investigated the correlation between intact parathyroid hormone (PTH), alkaline phosphatase (ALP) and the uptake ratios S and R.


RESULTS
Intact PTH had a significantly linear correlation with R (r = 0.745, p < 0.0001) and S (r = 0.702, p = 0.0001). ALP also had a significantly linear correlation with R (r = 0.537, p = 0.009) and S (r = 0.772, p < 0.0001).


CONCLUSIONS
The measurement of the bone soft tissue ratio of radius on bone scintigraphy was crucial for estimating renal osteodystrophy.
Nishida
Hidemi
H
Department of Nephrology and Dialysis Unit, Kurume University School of Medicine, Fukuoka, Japan. hide@med.kurume-u.ac.jp
Kaida
Hayato
H
Ishibashi
Masatoshi
M
Hiromatsu
Yuji
Y
Baba
Kenkichi
K
Iida
Shuji
S
Okuda
Seiya
S
D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000097:blood / Q000000981:diagnostic imaging* / Q000209:etiology / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D011379:Prognosis; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D011884:Radius / Q000000981:diagnostic imaging* / Q000378:metabolism*; D006435:Renal Dialysis / Q000009:adverse effects*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012886:Skull / Q000000981:diagnostic imaging* / Q000378:metabolism*; D013669:Technetium Tc 99m Medronate / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
D010281:Parathyroid Hormone; D019275:Radiopharmaceuticals; C024226:technetium Tc 99m hydroxymethylene diphosphonate; D000469:Alkaline Phosphatase; D013669:Technetium Tc 99m Medronate