Isolation and expression patterns of genes for three angiopoietin-like proteins, Angptl1, 2 and 6 in zebrafish.
Angiopoietin-like proteins (Angptls) are known to possess biological activities not only in the vascular system, but in the other mammalian tissues; however, their expression patterns and function in embryogenesis have not been extensively characterized. Here, we identify three zebrafish genes (Zangptl1, Zangptl2 and Zangptl6) highly homologous to mammalian Angptl1/ARP1, Angptl2/ARP2 and Angptl6/AGF, and describe their adult and embryonic temporal and spatial expression patterns. Zangptl1 is expressed faintly in the somites, while Zangptl2 is first detected in the yolk sac extension, spinal cord and branchial arches and is later expressed in the liver primordium and pectoral fin buds. Zangptl6 is expressed in the notochord. In addition to its embryonic expression, Zangptl2 is induced in adult fish during fin regeneration.
Kubota
Yoshiaki
Y
The Sakaguchi Laboratory, Department of Cell Differentiation, School of Medicine, Keio University, Tokyo, Japan.
Oike
Yuichi
Y
Satoh
Shinya
S
Tabata
Yoko
Y
Niikura
Yuichi
Y
Morisada
Tohru
T
Akao
Masaki
M
Urano
Takashi
T
Ito
Yasuhiro
Y
Miyamoto
Takeshi
T
Watanabe
Sumiko
S
Suda
Toshio
T
D000091304:Angiopoietin-Like Protein 1; D000091302:Angiopoietin-Like Protein 2; D000091308:Angiopoietin-Like Protein 6; D000075802:Angiopoietin-like Proteins; D042682:Angiopoietins / Q000096:biosynthesis*; D000818:Animals; D001798:Blood Proteins / Q000096:biosynthesis*; D003001:Cloning, Molecular; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D036341:Intercellular Signaling Peptides and Proteins / Q000096:biosynthesis*; D018878:Limb Buds / Q000378:metabolism; D010802:Phylogeny; D012038:Regeneration; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013997:Time Factors; D014018:Tissue Distribution; D015027:Zebrafish; D029961:Zebrafish Proteins / Q000096:biosynthesis*
C117578:ANGPTL1 protein, human; C485792:ANGPTL2 protein, human; D000091304:Angiopoietin-Like Protein 1; D000091302:Angiopoietin-Like Protein 2; D000091308:Angiopoietin-Like Protein 6; D000075802:Angiopoietin-like Proteins; D042682:Angiopoietins; C504920:Angptl1 protein, zebrafish; C504922:Angptl6 protein, zebrafish; D001798:Blood Proteins; D036341:Intercellular Signaling Peptides and Proteins; D029961:Zebrafish Proteins; C504921:angptl2b protein, zebrafish