[The study on effect of Sarcandra glabra on prevention and treatment of thrombocytopenia by chemotherapy].
OBJECTIVE
To investigate the effect of Sarcandra glabra Thunb on prevention and treatment of thrombocytopenia after chemotherapy with a large dosage.


METHODS
The Babl/c mice model of thrombocytopenia was made by intraperitoneal injection of 5-FU at a large dosage. All mice were poured Sarcandra glabra Thunb dilution to the mice's stomach once daily from the beginning of the experiment. Then the effect was analyzed by measuring peripheral blood cell counts of the mice on the 2nd day, the 4th day and the 7th day after chemotherapy. On the end of 7th day, all mice were killed, and then bone marrow biopsy was employed to investigate the hemapoietic condition.


RESULTS
Before the chemotherapy, the platelet counts of mice treated by Sarcandra glabra Thunb were higher than that in the control group (P < 0.05). After chemotherapy with 5-FU, the platelet counts were not significantly decreased in two all experimental groups compared with negative control group (P < 0.05), while there was not significantly different between two experimental groups (P > 0.05). Moreover the marrow biopsy showed that bone marrow hyperplasia was active in two intervention study groups with some megaryocytes in the medullary cavity of bone while bone marrow hyperplasia was low in the control group without any megaryocyte in the medullary cavity of bone.


CONCLUSIONS
The Sarcandra glabra Thunb had obvious activity in treatment to therombocytopenia and can prevent thrombocytopenia by 5-FU.
Zhong
Liye
L
The Department of Hematology, Guangdong People' s Hospital, Guangzhou 510080.
Liu
Tianhao
T
Chen
Yunxian
Y
Zhong
Xueyun
X
Du
Xin
X
Lu
Zesheng
Z
Weng
Jianyu
J
Wu
Suijing
S
Lin
Wei
W
D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D004906:Erythrocyte Count; D005472:Fluorouracil / Q000008:administration & dosage; D006410:Hematopoiesis / Q000187:drug effects; D019684:Magnoliopsida / Q000737:chemistry*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010946:Plants, Medicinal / Q000737:chemistry*; D010976:Platelet Count; D013921:Thrombocytopenia / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*
D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal; D005472:Fluorouracil