title: Endoscopic treatment of thoracic esophageal anastomotic leaks by using silicone-covered, self-expanding polyester stents.
abstract: BACKGROUND
  Surgery, as well as conservative treatment, in patients with clinically apparent intrathoracic esophageal anastomotic leaks often is associated with poor results and carries a high morbidity and mortality. The successful treatment of esophageal anastomotic insufficiencies and perforations when using covered, self-expanding metallic stents is described.
  
  
  METHODS
  The feasibility and the outcome of endoscopic treatment of intrathoracic anastomotic leakages when using silicone-covered self-expanding polyester stents were investigated. Twelve consecutive patients presented with clinically apparent intrathoracic esophageal anastomotic leak caused by resection of an epiphrenic diverticulum (n = 1), esophagectomy for esophageal cancer (n = 9), or gastrectomy for gastric cancer (n = 2), were endoscopically treated in our department. The extent of the dehiscences ranged from about 20% to 70% of the anastomotic circumference. After endoscopic lavage and debridement of the leakage at 2-day intervals (mean duration, 8.6 days), a large-diameter polyester stent (Polyflex; proximal/distal diameters 25/21 mm) was placed to seal the leakage. Simultaneously, the periesophageal mediastinum was drained by chest drains.
  
  
  METHODS
  All 12 patients were successfully treated endoscopically without the need for reoperation. A complete closure of the leakage was obtained in 11 of 12 patients after stent removal (median time to stent retrieval, 4 weeks, range 2-8 weeks). In one patient, a persistent leak was sealed endoscopically after stent removal by using 3 clips. Distal stent migration was obtained in two patients.
  
  
  CONCLUSIONS
  The placement of silicone-covered self-expanding polyester stents seems to be a successful minimally invasive treatment option for clinically apparent intrathoracic esophageal anastomotic leaks.
authors.affiliation: Department of General, Visceral and Vascular Surgery, Faculty of Medicine, Otto von Guericke University Magdeburg, Magdeburg, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Schubert
authors.forename: Hubert
authors.initials: H
authors.lastname: Scheidbach
authors.forename: Roger
authors.initials: R
authors.lastname: Kuhn
authors.forename: Cora
authors.initials: C
authors.lastname: Wex
authors.forename: Guenter
authors.initials: G
authors.lastname: Weiss
authors.forename: Frank
authors.initials: F
authors.lastname: Eder
authors.forename: Hans
authors.initials: H
authors.lastname: Lippert
authors.forename: Matthias
authors.initials: M
authors.lastname: Pross
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical / Q000009:adverse effects*; D004936:Diverticulum, Esophageal / Q000601:surgery; D004867:Equipment Design; D004938:Esophageal Neoplasms / Q000601:surgery; D004939:Esophageal Perforation / Q000601:surgery; D016629:Esophagectomy; D004945:Esophagoscopy / Q000379:methods*; D004947:Esophagus / Q000601:surgery*; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures; D011091:Polyesters; D012828:Silicones; D015607:Stents; D013274:Stomach Neoplasms / Q000601:surgery; D013529:Surgical Wound Dehiscence / Q000601:surgery; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology
chemical_list: D011091:Polyesters; D012828:Silicones