title: [Two cases of malignant tumors of the face after hematopoietic stem cell transplantation].
abstract: BACKGROUND
  Malignant solid tumors are a complication of hematopoietic stem cell transplantation (HSCT).
  
  
  METHODS
  Two patients underwent HSCT for acute leukemia. Chronic graft-versus-host disease (GVHD) developed. At 5 years one patient developed squamous cell carcinoma of the tongue and the other mucoepidermoid carcinoma of the parotid gland.
  
  
  CONCLUSIONS
  Several factors are involved in the development of secondary malignant tumors after HSCT. Pre- and post-graft immunosuppressive treatment inhibits the defence system and cell repair and can trigger chronic GVHD with chronic inflammation of the epithelial tissue leading to accelerated cell turn over and a risk of genetic anomalies favoring penetration of viral particles. Squamous cell carcinoma of the oral cavity after HSCT presents the same clinical, histological and prognostic features as in the non-grafted patient. These patients require prolonged surveillance. Improved grafting and ant-HPV vaccination techniques may reduce the risk of cancer after HSCT.
authors.affiliation: Service de Chirurgie maxillo-faciale, stomatologie et plastique de la face, Centre hospitalier Lyon-Sud.
authors.forename: A
authors.initials: A
authors.lastname: Girod
authors.forename: P
authors.initials: P
authors.lastname: Breton
mesh_terms: D000328:Adult; D018277:Carcinoma, Mucoepidermoid / Q000209:etiology*; D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D010307:Parotid Neoplasms / Q000209:etiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy; D014062:Tongue Neoplasms / Q000209:etiology*