title: Spinal and extracranial metastatic dissemination of malignant glioma.
abstract: Metastatic dissemination of malignant glioma is rare. Metastatic disease usually occurs within the neuraxis but extracranial spread to the liver, spleen, lung, peritoneum and lymph nodes can also occur. In most cases of metastatic disease, the patient has previously undergone a craniotomy. The prognosis is uniformly poor. The vast majority of patients do not survive beyond six months from diagnosis of metastatic spread of a primary intracranial tumour. The pathophysiology and natural history of this condition is still not fully understood, hence well-designed prospective studies are needed.
authors.affiliation: Department of Neurosurgery, National Neuroscience Institute, Tan Tock Seng, Singapore. wai_hoe_ng@ttsh.com.sg
authors.forename: Wai Hoe
authors.initials: WH
authors.lastname: Ng
authors.forename: Tseng Tsai
authors.initials: TT
authors.lastname: Yeo
authors.forename: Andrew H
authors.initials: AH
authors.lastname: Kaye
mesh_terms: D001932:Brain Neoplasms / Q000453:epidemiology / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D005910:Glioma / Q000453:epidemiology / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D009362:Neoplasm Metastasis; D012196:Review Literature as Topic; D013120:Spinal Cord Neoplasms / Q000453:epidemiology / Q000556:secondary*; D013160:Splenic Neoplasms / Q000556:secondary