title: [Role of PAI-1 in gynaecological malignancies].
abstract: The plasminogen activator-plasmin cascade plays a central role in tumor cell invasion and metastasis of solid tumors. The type-1 plasminogen activator inhibitor (PAI-1) is the major physiologic regulator of the plasminogen activation. The PAI-1 is suggested to play a crucial role in tumor cell invasion and metastasis of different solid tumors. The aim of this article is to give an overview of the function, clinical and prognostic role of PAI-1 in gynaecological malignancies.
authors.affiliation: Klinik für Frauenheilkunde und Geburtshilfe, Campus Virchow-Klinikum, Charité Universitätsmedizin Berlin.
authors.forename: D
authors.initials: D
authors.lastname: Könsgen
authors.forename: A
authors.initials: A
authors.lastname: Mustea
authors.forename: W
authors.initials: W
authors.lastname: Lichtenegger
authors.forename: J
authors.initials: J
authors.lastname: Sehouli
mesh_terms: D005260:Female; D005833:Genital Neoplasms, Female / Q000473:pathology*; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D017395:Plasminogen Activator Inhibitor 1 / Q000502:physiology*; D011379:Prognosis
chemical_list: D017395:Plasminogen Activator Inhibitor 1