Coordinate gene regulation by two different catenins.
In this issue of Developmental Cell, McCrea and colleagues report that p120-catenin regulates the same Wnt target genes as beta-catenin in the Xenopus embryo (). These findings raise the exciting possibility that these two related proteins function in parallel to mediate cadherin-associated regulation of gene expression.
Gumbiner
Barry M
BM
Department of Cell Biology, School of Medicine, University of Virginia, Post Office Box 800732, Charlottesville, Virginia 22908, USA.
D000818:Animals; D051177:Catenins; D015815:Cell Adhesion Molecules / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000502:physiology*; D004625:Embryo, Nonmammalian; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D010750:Phosphoproteins / Q000502:physiology*; D015534:Trans-Activators / Q000502:physiology*; D051153:Wnt Proteins; D014981:Xenopus; D029867:Xenopus Proteins; D051176:beta Catenin; D000095002:Delta Catenin
C495266:CTNNB1 protein, Xenopus; D051177:Catenins; D015815:Cell Adhesion Molecules; D003598:Cytoskeletal Proteins; D036341:Intercellular Signaling Peptides and Proteins; D010750:Phosphoproteins; D015534:Trans-Activators; D051153:Wnt Proteins; D029867:Xenopus Proteins; D051176:beta Catenin; D000095002:Delta Catenin