Practical formulation and process development of freeze-dried products.
Freeze-drying science and technology continues to evolve and increase in importance because of the emergence of biotechnology drugs that are too unstable to be commercially available as ready-to-use solutions. As more new drug compounds need to be developed as freeze-dried products, this mini-review article provides practical guidance and commentary on the latest literature articles on formulation and process development of freeze-dried products. This article contains a table that provides the quantitative formulations of all commercial freeze-dried protein pharmaceutical products through 2004.
Schwegman
J Jeff
JJ
Baxter BioPharma Solutions, Bloomington, IN, USA.
Hardwick
Lisa M
LM
Akers
Michael J
MJ
D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D004355:Drug Stability; D005079:Excipients; D005612:Freeze Drying / Q000379:methods*; D012997:Solvents
D005079:Excipients; D012997:Solvents