title: Synthesis and biological evaluation of novel bisphosphonates with dual activities on bone in vitro.
abstract: In an effort to generate novel anti-osteoporosis agents, new bisphosphonates with various benzoyl groups on side chains have been synthesized and evaluated for activities on both bone resorption and bone formation in vitro. Several candidates showed distinct dual activities: promoting bone formation and inhibiting bone resorption.
authors.affiliation: Department of Medicine, Columbia University, NY 10032, USA.
authors.forename: Yuli
authors.initials: Y
authors.lastname: Xie
authors.forename: Huasheng
authors.initials: H
authors.lastname: Ding
authors.forename: Lihui
authors.initials: L
authors.lastname: Qian
authors.forename: Xueming
authors.initials: X
authors.lastname: Yan
authors.forename: Chunhao
authors.initials: C
authors.lastname: Yang
authors.forename: Yuyuan
authors.initials: Y
authors.lastname: Xie
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis; D016723:Bone Remodeling / Q000187:drug effects*; D001862:Bone Resorption; D049109:Cell Proliferation / Q000187:drug effects; D004164:Diphosphonates / Q000138:chemical synthesis* / Q000494:pharmacology; D010010:Osteoclasts / Q000166:cytology / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects; D010024:Osteoporosis / Q000188:drug therapy; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D015415:Biomarkers; D004164:Diphosphonates