Function of GABAergic and glutamatergic neurons in the stomach.
Gamma-aminobutyric acid (GABA) and L-glutamic acid (L-Glu) are transmitters of GABAergic and glutamatergic neurons in the enteric interneurons, targeting excitatory or inhibitory GABA receptors or glutamate receptors that modulate gastric motility and mucosal function. GABAergic and glutamatergic neuron immunoreactivity have been found in cholinergic enteric neurons in the stomach. GABA and L-Glu may also subserve hormonal and paracrine signaling. Disruption in gastrointestinal function following perturbation of enteric GABA receptors and glutamate receptors presents potential new target sites for drug development.
Tsai
Li Hsueh
LH
Department of Physiology, School of Medicine, Taipei Medical University, Taipei, 11014, Taiwan. lhtsai@tmu.edu.tw
D000818:Animals; D002490:Central Nervous System / Q000378:metabolism; D005247:Feeding Behavior; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism*; D005973:Glutamine / Q000378:metabolism*; D006801:Humans; D009092:Mucous Membrane / Q000378:metabolism; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000166:cytology; D009474:Neurons / Q000378:metabolism*; D011950:Receptors, Cholinergic / Q000378:metabolism; D018079:Receptors, GABA / Q000378:metabolism*; D017470:Receptors, Glutamate / Q000378:metabolism; D015398:Signal Transduction; D014456:Ulcer
D011950:Receptors, Cholinergic; D018079:Receptors, GABA; D017470:Receptors, Glutamate; D005973:Glutamine