Synthesis of glycoporphyrin derivatives and their antiviral activity against herpes simplex virus types 1 and 2.
Studies on the synthesis, structural elucidation, and antiviral evaluation of several carbohydrate-substituted meso-tetraarylporphyrins against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are described. The potential of those photosensitizers, and of their precursors, on the photoinactivation of HSV-1 and HSV-2 was examined in Vero cells. Their virucidal and viral replication effects were assessed under white light, at their maximum noncytotoxic concentrations. The highest inhibitory effects on viral replication, for both viruses, were obtained with the glycoporphyrins where the sugar moiety bears unprotected hydroxyl groups. Strong inhibition of virus yield was observed even at concentrations much lower than their maximum noncytotoxic concentrations. These compounds can be postulated to be useful as potential drugs for the treatment of herpes simplex viruses infections.
Tomé
João P C
JP
Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Neves
Maria G P M S
MG
Tomé
Augusto C
AC
Cavaleiro
José A S
JA
Mendonça
Ana F
AF
Pegado
Inês N
IN
Duarte
Ricardo
R
Valdeira
Maria L
ML
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002522:Chlorocebus aethiops; D006021:Glycophorins / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D006561:Herpes Simplex / Q000188:drug therapy; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D018258:Herpesvirus 2, Human / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D010778:Photochemotherapy / Q000379:methods*; D013329:Structure-Activity Relationship; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D006021:Glycophorins