Hormone replacement therapy and risk of nonfatal acute myocardial infarction in Italy.
BACKGROUND
Observational studies, but not clinical trials, found lower risk of coronary heart disease (CHD) in hormone replacement therapy (HRT) users. We analyzed the relation between HRT use and the risk of nonfatal acute myocardial infarction (AMI) in Italy.


METHODS
We used a combined dataset from three hospital-based case-control studies including a total of 479 women aged > or =45 years with a first episode of nonfatal AMI and 822 hospital controls.


RESULTS
Compared to never-HRT users, the multivariate odds ratio in ever users was 1.4 (95% confidence interval, 0.9-2.2); no consistent pattern of risk was observed according to duration or time since last use.


CONCLUSIONS
HRT use was not associated with nonfatal AMI in Italian women according to the findings of clinical trials.
Tavani
Alessandra
A
Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, Milan 20157, Italy. tavani@marionegri.it
Bertuzzi
Michaela
M
Gallus
Silvano
S
Negri
Eva
E
La Vecchia
Carlo
C
D017677:Age Distribution; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology / Q000209:etiology*; D016017:Odds Ratio; D012307:Risk Factors