title: IMGT unique numbering for MHC groove G-DOMAIN and MHC superfamily (MhcSF) G-LIKE-DOMAIN.
abstract: IMGT, the international ImMunoGeneTics information system (http://imgt.cines.fr) provides a common access to expertly annotated data on the genome, proteome, genetics and structure of immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC), and related proteins of the immune system (RPI) of human and other vertebrates. The NUMEROTATION concept of IMGT-ONTOLOGY has allowed to define a unique numbering for the variable domains (V-DOMAINs) and constant domains (C-DOMAINs) of the IG and TR, which has been extended to the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily (IgSF) proteins other than the IG and TR (Dev Comp Immunol 27:55--77, 2003; 29:185--203, 2005). In this paper, we describe the IMGT unique numbering for the groove domains (G-DOMAINs) of the MHC and for the G-LIKE-DOMAINs of the MHC superfamily (MhcSF) proteins other than MHC. This IMGT unique numbering leads, for the first time, to the standardized description of the mutations, allelic polymorphisms, two-dimensional (2D) representations and three-dimensional (3D) structures of the G-DOMAINs and G-LIKE-DOMAINs in any species, and therefore, is highly valuable for their comparative, structural, functional and evolutionary studies.
authors.affiliation: IMGT, the international ImMunoGeneTics information system, Laboratoire d'ImmunoGénétique Moléculaire, LIGM, Université Montpellier II, Institut de Génétique Humaine, IGH UPR CNRS 1142, 34396 Montpellier cedex 5, France. lefranc@ligm.igh.cnrs.fr
authors.forename: Marie-Paule
authors.initials: MP
authors.lastname: Lefranc
authors.forename: Elodie
authors.initials: E
authors.lastname: Duprat
authors.forename: Quentin
authors.initials: Q
authors.lastname: Kaas
authors.forename: Madeleine
authors.initials: M
authors.lastname: Tranne
authors.forename: Aude
authors.initials: A
authors.lastname: Thiriot
authors.forename: Gérard
authors.initials: G
authors.lastname: Lefranc
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D030541:Databases, Genetic; D006649:Histocompatibility Antigens / Q000737:chemistry* / Q000145:classification* / Q000235:genetics; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000145:classification / Q000235:genetics; D000949:Histocompatibility Antigens Class II / Q000737:chemistry / Q000145:classification / Q000235:genetics; D006801:Humans; D007256:Information Systems; D008285:Major Histocompatibility Complex; D051379:Mice; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D017386:Sequence Homology, Amino Acid; D009626:Terminology as Topic
chemical_list: D006649:Histocompatibility Antigens; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II