title: Immunohistochemical expression of calretinin in canine testicular tumours and normal canine testicular tissue.
abstract: Calretinin is a calcium-binding protein expressed abundantly in the central and peripheral neural tissues. It has been demonstrated to be a valuable marker in human testicular neoplasia. The immunohistochemical expression of calretinin has been studied in 102 samples of normal (n=25) and three different neoplastic canine testicular tumours (n=77). In normal canine testis, calretinin expression was restricted to Leydig and Sertoli cells of the testis. In tumour tissues, calretinin expression was detected in all tumours investigated (interstitial cell tumours, seminoma, and Sertoli cell tumours), with a cytoplasmic and nuclear pattern of cellular distribution. The present work reports, for the first time, calretinin immunohistochemical expression in normal and neoplastic canine testis.
authors.affiliation: Veterinary Diagnostic and Investigational Laboratory, College of Veterinary Medicine, The University of Georgia, P.O. Box 1389, Tifton, GA 31794, USA.
authors.forename: Z A
authors.initials: ZA
authors.lastname: Radi
authors.forename: D L
authors.initials: DL
authors.lastname: Miller
mesh_terms: D000818:Animals; D064032:Calbindin 2; D004283:Dog Diseases / Q000378:metabolism*; D004285:Dogs; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D007984:Leydig Cell Tumor / Q000378:metabolism / Q000662:veterinary; D008297:Male; D064030:S100 Calcium Binding Protein G / Q000096:biosynthesis*; D018239:Seminoma / Q000378:metabolism / Q000662:veterinary; D012707:Sertoli Cell Tumor / Q000378:metabolism / Q000662:veterinary; D013736:Testicular Neoplasms / Q000378:metabolism / Q000662:veterinary*; D013737:Testis / Q000378:metabolism*
chemical_list: C576764:CALB2 protein, human; D064032:Calbindin 2; D064030:S100 Calcium Binding Protein G