Glomerular permeability defect in hypertension is dependent on renin angiotensin system activation.
BACKGROUND
The aim of the present study was to compare glomerular permeability alterations associated with experimental hypertension models known to have different effects on the circulating renin-angiotensin system (RAS).


METHODS
Five groups, 10 animals each, were studied. One group served as a nonhypertensive control. The other four groups of hypertensive animals were composed of spontaneously hypertensive rats, deoxycorticosterone acetate hypertensive rats, Goldblatt two-kidney, one-clip rats, and a group of Wistar rats infused with angiotensin II (200 ng/kg/min). Tail-cuff sphygmomanometric systolic blood pressure (BP), albumin permeability determined in isolated glomeruli exposed to oncotic gradients (P(alb)), glomerular filtration rate (GFR, iopamidol method), plasma renin activity (PRA), and albuminuria were evaluated.


RESULTS
Alterations in P(alb) and albumin excretion rate were more evident in the experimental models with an activation of the RAS despite similar levels of systolic BP and GFR. A positive correlation was found between P(alb) and albuminuria (r = 0.51; P < .001) and between systolic BP and albuminuria (r = 0.37; P < .01). No relation was found between systolic BP and P(alb).


CONCLUSIONS
The present study indicates that the activation of the RAS plays a significant role in the development of glomerular albumin permeability defects in hypertensive models and may contribute to the mechanisms that lead to target organ damage in hypertension.
Candido
Riccardo
R
Department of Medicina Clinica and Neurologia, University of Trieste, Trieste, Italy.
Carraro
Michele
M
Fior
Francesco
F
Artero
Mary L
ML
Zennaro
Cristina
C
Burrell
Louise M
LM
Davis
Belinda J
BJ
Cattin
Maria Rosa
MR
Bardelli
Moreno
M
Faccini
Luigi
L
Carretta
Renzo
R
Fabris
Bruno
B
D000418:Albumins / Q000378:metabolism; D000804:Angiotensin II / Q000493:pharmacokinetics; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002463:Cell Membrane Permeability / Q000502:physiology; D003900:Desoxycorticosterone / Q000031:analogs & derivatives / Q000633:toxicity; D004195:Disease Models, Animal; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism*; D007678:Kidney Glomerulus / Q000378:metabolism*; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D020303:Rats, Inbred Dahl; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000502:physiology*; D014662:Vasoconstrictor Agents / Q000493:pharmacokinetics
D000418:Albumins; D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D003900:Desoxycorticosterone; D012083:Renin