title: Effects of dietary phosphorus intake on bone mineralization and calcium absorption in adult female rats.
abstract: We investigated the effects of dietary phosphorus (P) intake on the bone mineralization and calcium (Ca) absorption in adult female rats. Fifteen 16-wk-old female Wistar rats were divided into three groups, and respectively fed a low-P diet containing 0.15% P (LP), a control diet containing 0.5% P (C), and a high-P diet containing 1.5% P (HP) for 42 d. The apparent Ca absorption was significantly increased with decreasing dietary P level. The serum parathyroid hormone concentration was significantly lower in the LP group than in the C and HP groups. The serum osteocalcin concentration and urinary excretion of deoxypyridinoline were significantly higher in the HP groups than in the LP and C groups. The bone mineral density of the fifth lumbar vertebra was significantly increased with decreasing dietary P level. These results indicate that the low-P diet increased Ca absorption, this being effective for bone mineralization in adult female rats.
authors.affiliation: Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture.
authors.forename: Moyuru
authors.initials: M
authors.lastname: Koshihara
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Katsumata
authors.forename: Mariko
authors.initials: M
authors.lastname: Uehara
authors.forename: Kazuharu
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D002113:Calcification, Physiologic / Q000187:drug effects* / Q000502:physiology; D002118:Calcium / Q000378:metabolism*; D005260:Female; D007408:Intestinal Absorption / Q000187:drug effects; D010281:Parathyroid Hormone / Q000502:physiology; D016226:Phosphorus, Dietary / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010281:Parathyroid Hormone; D016226:Phosphorus, Dietary; D002118:Calcium