title: Discovery of pyrimidyl-5-hydroxamic acids as new potent histone deacetylase inhibitors.
abstract: A series of pyrimidyl-5-hydroxamic acids was prepared for evaluation as inhibitors of histone deacetylase (HDAC). Amino-2-pyrimidinyl can be used as a linker to provide HDAC inhibitors of good enzymatic potency.
authors.affiliation: Johnson&Johnson Pharmaceutical Research&Development (J&JPRD), Medicinal Chemistry Department, campus de Maigremont BP615, 27106 Val de Reuil, France. pangibau@PRDFR.jnj.com
authors.forename: Patrick
authors.initials: P
authors.lastname: Angibaud
authors.forename: Janine
authors.initials: J
authors.lastname: Arts
authors.forename: Kristof
authors.initials: K
authors.lastname: Van Emelen
authors.forename: Virginie
authors.initials: V
authors.lastname: Poncelet
authors.forename: Isabelle
authors.initials: I
authors.lastname: Pilatte
authors.forename: Bruno
authors.initials: B
authors.lastname: Roux
authors.forename: Sven
authors.initials: S
authors.lastname: Van Brandt
authors.forename: Marc
authors.initials: M
authors.lastname: Verdonck
authors.forename: Hans
authors.initials: H
authors.lastname: De Winter
authors.forename: Peter
authors.initials: P
authors.lastname: Ten Holte
authors.forename: Ann
authors.initials: A
authors.lastname: Marien
authors.forename: Wim
authors.initials: W
authors.lastname: Floren
authors.forename: Boudewijn
authors.initials: B
authors.lastname: Janssens
authors.forename: Jacky
authors.initials: J
authors.lastname: Van Dun
authors.forename: An
authors.initials: A
authors.lastname: Aerts
authors.forename: Jacky
authors.initials: J
authors.lastname: Van Gompel
authors.forename: Sandrine
authors.initials: S
authors.lastname: Gaurrand
authors.forename: Laurence
authors.initials: L
authors.lastname: Queguiner
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Argoullon
authors.forename: Luc
authors.initials: L
authors.lastname: Van Hijfte
authors.forename: Eddy
authors.initials: E
authors.lastname: Freyne
authors.forename: Michel
authors.initials: M
authors.lastname: Janicot
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D006367:HeLa Cells; D056572:Histone Deacetylase Inhibitors; D006801:Humans; D006877:Hydroxamic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; D006877:Hydroxamic Acids; D011743:Pyrimidines