[An autopsied case of metastatic endocrine carcinoma of the pancreas with primary site difficult to identify].
A 40-year-old man suffering from right cheek swelling was first diagnosed with ameloblastoma or anaplastic poorly-differentiated carcinoma of the head and neck region. He received 2 courses of CDDP/TXT chemotherapy (cisplatin 75 mg/m2, docetaxel 80 mg/m2) and achieved a partial response, but his carcinoma of the pancreas recurred. He also achieved a partial response with 2 courses of CBDCA/TXL regimen (carboplatin AUC=6, paclitaxel 200 mg/m2), but later died from his progressive disease. The autopsy revealed a pathological diagnosis of metastatic endocrine carcinoma of the pancreas. This case was close to a cancer with an unknown primary (CUP) site, and several favorable sub-sets of CUP have been identified, which are responsive to systemic chemotherapy. Poorly-differentiated neuroendocrine carcinomas like this case are highly sensitive to chemotherapy, and a careful pathological diagnosis may clarify its sensitivity to chemotherapy and the prognosis.
Nishimori
Hisakazu
H
Dept. of Medical Oncology, Cancer Institute Hospital.
Takahashi
Shunji
S
Nagasaki
Eijiro
E
Kobayashi
Takayuki
T
Yokoyama
Masahiro
M
Shinozaki
Eiji
E
Mishima
Yuko
Y
Terui
Yasuhito
Y
Chin
Keisyo
K
Mizunuma
Nobuyuki
N
Ito
Yoshinori
Y
Inamura
Kentaro
K
Hatake
Kiyohiko
K
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage; D002277:Carcinoma / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D002945:Cisplatin / Q000008:administration & dosage; D000077143:Docetaxel; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009362:Neoplasm Metastasis; D009382:Neoplasms, Unknown Primary / Q000473:pathology*; D017239:Paclitaxel / Q000008:administration & dosage; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D043823:Taxoids / Q000008:administration & dosage
D043823:Taxoids; D000077143:Docetaxel; D016190:Carboplatin; D017239:Paclitaxel; D002945:Cisplatin