title: Photodynamic therapy of high grade glioma - long term survival.
abstract: Haemetaporphyrin derivative (HpD) mediated photodynamic therapy (PDT) has been investigated as an adjuvant treatment for cerebral glioma. This study records the survival of patients at the Royal Melbourne Hospital with residences in the State of Victoria, utilizing the Victorian Cancer Registry database for patients treated with adjuvant PDT following surgical resection of the tumour. For primary (newly diagnosed) tumours, median survival from initial diagnosis was 76.5 months for anaplastic astrocytoma (AA) and 14.3 months for glioblastoma multiforme (GBM). Seventy-three percent of patients with AA and 25% with GBM survived longer than 36 months. For recurrent tumour, median survival from the time of surgery was 66.6 months for AA and 13.5 months for GBM. Fifty-seven percent of patients with recurrent AA and 41% of patients with recurrent GBM survived longer than 36 months. Older age at the time of diagnosis was associated with poorer prognosis. Laser light doses above the sample median of 230 J/cm2 were associated with better prognosis in the 136 patients studied (primary tumour patients - (HR=0.50[0.27,0.95],p=0.033); recurrent tumour patients (HR=0.75[0.42,1.31],p=0.312). There was no mortality directly associated with the therapy, three patients had increased cerebral oedema thought to be related to photodynamic therapy that was controlled with conventional therapies.
authors.affiliation: Department of Neurosurgery, Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia.
authors.forename: Stanley S
authors.initials: SS
authors.lastname: Stylli
authors.forename: Andrew H
authors.initials: AH
authors.lastname: Kaye
authors.forename: Lachlan
authors.initials: L
authors.lastname: MacGregor
authors.forename: Megan
authors.initials: M
authors.lastname: Howes
authors.forename: Priya
authors.initials: P
authors.lastname: Rajendra
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D003131:Combined Modality Therapy / Q000379:methods; D016001:Confidence Intervals; D005260:Female; D005910:Glioma / Q000145:classification / Q000188:drug therapy* / Q000401:mortality*; D006415:Hematoporphyrins / Q000627:therapeutic use*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000379:methods*; D016016:Proportional Hazards Models; D016634:Radiosurgery / Q000379:methods; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors
chemical_list: D006415:Hematoporphyrins