title: Ground-based research with heavy ions for space radiation protection.
abstract: Human exposure to ionizing radiation is one of the acknowledged potential showstoppers for long duration manned interplanetary missions. Human exploratory missions cannot be safely performed without a substantial reduction of the uncertainties associated with different space radiation health risks, and the development of effective countermeasures. Most of our knowledge of the biological effects of heavy charged particles comes from accelerator-based experiments. During the 35th COSPAR meeting, recent ground-based experiments with high-energy iron ions were discussed, and these results are briefly summarised in this paper. High quality accelerator-based research with heavy ions will continue to be the main source of knowledge of space radiation health effects and will lead to reductions of the uncertainties in predictions of human health risks. Efforts in materials science, nutrition and pharmaceutical sciences and their rigorous evaluation with biological model systems in ground-based accelerator experiments will lead to the development of safe and effective countermeasures to permit human exploration of the Solar System.
authors.affiliation: Department of Physics, University Federico II, Monte S. Angelo, Via Cintia, Naples, Italy. durante@na.infn.it
authors.forename: M
authors.initials: M
authors.lastname: Durante
authors.forename: A
authors.initials: A
authors.lastname: Kronenberg
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations; D003198:Computer Simulation; D003359:Cosmic Radiation; D004249:DNA Damage; D005347:Fibroblasts / Q000528:radiation effects; D020450:Heavy Ions; D006801:Humans; D007501:Iron; D018499:Linear Energy Transfer; D051379:Mice; D008962:Models, Theoretical; D016296:Mutagenesis / Q000528:radiation effects; D010315:Particle Accelerators; D011829:Radiation Dosage; D011835:Radiation Protection; D011853:Radiobiology; D012542:Scattering, Radiation; D013026:Space Flight
chemical_list: D007501:Iron