title: Dramatic improvement of pyoderma gangrenosum with infliximab in a patient with PAPA syndrome.
abstract: Infliximab, a chimeric antitumor necrosis factor alpha monoclonal antibody (anti-TNF alpha), has been recently shown to have a beneficial effect on pyoderma gangrenosum associated with inflammatory bowel disease. Patients with the syndromic triad of pyogenic sterile arthritis, pyoderma gangrenosum, and acne, an autoinflammatory process caused by mutations in the CD2 binding protein-1 (CD2BP1) gene, can have severe pyoderma gangrenosum. We describe a 14-year-old patient with this syndrome who was unresponsive to multiple therapies. A dramatic improvement in his pyoderma gangrenosum was observed after one infusion of infliximab, and a second infusion led to its resolution. Our observation extends the therapeutic use of infliximab to this component of PAPA syndrome.
authors.affiliation: UT Southwestern Medical Center at Dallas and Texas Scottish Rite Hospital for Children, Dallas, Texas, USA.
authors.forename: Dorothee S
authors.initials: DS
authors.lastname: Stichweh
authors.forename: Marilynn
authors.initials: M
authors.lastname: Punaro
authors.forename: Virginia
authors.initials: V
authors.lastname: Pascual
mesh_terms: D000152:Acne Vulgaris / Q000235:genetics; D000293:Adolescent; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001168:Arthritis / Q000235:genetics; D003879:Dermatologic Agents / Q000627:therapeutic use*; D006801:Humans; D000069285:Infliximab; D008297:Male; D017511:Pyoderma Gangrenosum / Q000188:drug therapy* / Q000235:genetics; D013577:Syndrome
chemical_list: D000911:Antibodies, Monoclonal; D003879:Dermatologic Agents; D000069285:Infliximab