title: Associations between whole-blood serotonin and subjective mood in healthy male volunteers.
abstract: Little is known regarding the relationship between how mood is experienced and biochemical factors. This research has explored potential relationships between whole-blood serotonin (5-HT) and subjective mood, measured using the Positive and Negative Affect Schedule (PANAS), in healthy males (n=23). Univariate linear regression analysis indicated that 5-HT levels were positively related to positive affect (P=0.002) but not negative affect. Whole-blood 5-HT concentrations therefore appear to predict mood in healthy males. More research using larger samples and including females is needed to explore further associations between biomarkers and subjective measures of mood.
authors.affiliation: Northern Ireland Centre for Food and Health (NICHE), University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK.
authors.forename: Emma
authors.initials: E
authors.lastname: Williams
authors.forename: Barbara
authors.initials: B
authors.lastname: Stewart-Knox
authors.forename: Anders
authors.initials: A
authors.lastname: Helander
authors.forename: Christopher
authors.initials: C
authors.lastname: McConville
authors.forename: Ian
authors.initials: I
authors.lastname: Bradbury
authors.forename: Ian
authors.initials: I
authors.lastname: Rowland
mesh_terms: D000339:Affect / Q000502:physiology*; D006801:Humans; D008297:Male; D012701:Serotonin / Q000097:blood*
chemical_list: D012701:Serotonin