title: Research progress on Helicobacter pylori outer membrane protein.
abstract: Helicobacter pylori (H pylori), one of the most common bacterial pathogens on human beings, colonizes the gastric mucosa. In its 95 paralogous gene families, there is a large outer membrane protein (OMP) family. It includes 32 members. These OMP are important for the diagnosis, protective immunity, pathogenicity of H pylori and so on. They are significantly associated with high H pylori density, the damage of gastric mucosa, high mucosal IL-8 levels and severe neutrophil infiltration. We introduce their research progress on pathogenicity.
authors.affiliation: Department of Medical Microbiology and Parasitology, Medical Technology College, Jiangsu University, Zhenjiang 212001, Jiangsu Province, China. ljxwl123@163.com
authors.forename: Shi-He
authors.initials: SH
authors.lastname: Shao
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.forename: Shun-Gen
authors.initials: SG
authors.lastname: Chai
authors.forename: Li-Mei
authors.initials: LM
authors.lastname: Liu
mesh_terms: D001425:Bacterial Outer Membrane Proteins / Q000502:physiology*; D005753:Gastric Mucosa / Q000382:microbiology; D005756:Gastritis / Q000382:microbiology; D016481:Helicobacter Infections / Q000382:microbiology / Q000503:physiopathology; D016480:Helicobacter pylori / Q000472:pathogenicity* / Q000502:physiology*; D006801:Humans; D010437:Peptic Ulcer / Q000382:microbiology; D013274:Stomach Neoplasms / Q000382:microbiology
chemical_list: D001425:Bacterial Outer Membrane Proteins