Chemical library synthesis using convergent approaches.
New strategies are continuously being developed in combinatorial and diversity-oriented synthesis. Convergent design in target-oriented synthesis is commonly employed for construction of complex molecules. In this mini-review, we describe examples of convergent library design and synthesis as well as potential areas for future development.
Beeler
Aaron B
AB
Department of Chemistry and Center for Chemical Methodology and Library Development, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.
Schaus
Scott E
SE
Porco
John A
JA
D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D008956:Models, Chemical; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis* / Q000737:chemistry
D004364:Pharmaceutical Preparations