Cardiac findings in adolescents with anorexia nervosa at diagnosis and after weight restoration.
The aim of this study was to compare heart abnormalities in a group of young women with anorexia nervosa at diagnosis and after weight restoration. A total of 40 young women with anorexia nervosa were evaluated, at baseline, (diagnosis) and follow-up (9 to 18 months later) and matched with 40 healthy women of the same age and of normal weight. QT interval was measured from surface electrocardiograms. QT dispersion was defined as the difference between maximum QT and minimum QT occurring in any of the 12 leads. Left ventricular end-diastolic diameter, left ventricular end-systolic diameter, left ventricular mass, left ventricular mass index, cardiac output, fractional shortening and fractional ejection, were measured by echocardiography. In anorexia nervosa patients, corrected QT interval and QT dispersion, significantly decreased from baseline to follow-up. Left ventricular end-diastolic dimension, left ventricular mass index, and cardiac output, in anorexia nervosa were significantly lower at diagnosis than at follow-up after weight restoration.


CONCLUSIONS
Adolescents with anorexia nervosa have significant functional and structural cardiac abnormalities; weight gain was associated with improvement. Appropriate attention should be paid to cardiac involvement.
Olivares
José L
JL
Department of Paediatrics, "Lozano Blesa" Hospital, University of Zaragoza School of Medicine, C/ Domingo Miral s/n, 50009, Zaragoza, Spain. olivares@unizar.es
Vázquez
Margarita
M
Fleta
Jesús
J
Moreno
Luis A
LA
Pérez-González
José M
JM
Bueno
Manuel
M
D000293:Adolescent; D000704:Analysis of Variance; D000856:Anorexia Nervosa / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy; D001145:Arrhythmias, Cardiac / Q000209:etiology; D002302:Cardiac Output; D009202:Cardiomyopathies / Q000209:etiology; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006331:Heart Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D013030:Spain / Q000453:epidemiology; D014463:Ultrasonography