title: [Effect of inorganic nitrates on the morphofunctional condition of the kidney in the rat].
abstract: OBJECTIVE
  The aim of our experimental study was to determine the effect of exogenic nitrates on certain biological parameters in relation to renal insufficiency.
  
  
  RESULTS
  Chronic treatment of rats for 5 months with varying nitrate concentrations (50, 100, 150 and 500 mg/L) induced a dose-dependent reduction in plasma concentrations of total proteins and a dose-dependent increase in plasma urea concentrations and creatinine.
  
  
  CONCLUSIONS
  This histological study of the kidney shows that nitrates at doses of 150 and 500 mg/L cause a deterioration in the epithelia of the renal tubules.
  
  
  CONCLUSIONS
  In conclusion, a high nitrate intake induces morphofunctional disturbances of the kidney and could thus be regarded as a causative factor in renal insufficiency.
authors.affiliation: Laboratoire de Physiologie Animale, Faculté des Sciences et Techniques, Béni Mellal, Maroc. zakix@doctor.com
authors.forename: Abdelwahab
authors.initials: A
authors.lastname: Zaki
authors.forename: Ahmed Ait
authors.initials: AA
authors.lastname: Chaoui
authors.forename: Abderahman
authors.initials: A
authors.lastname: Chait
authors.forename: Touria
authors.initials: T
authors.lastname: Aboussaouira
authors.forename: Khadija
authors.initials: K
authors.lastname: Zarrouk
authors.forename: Thami
authors.initials: T
authors.lastname: Himmi
mesh_terms: D000818:Animals; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000473:pathology; D007677:Kidney Function Tests; D008297:Male; D009566:Nitrates / Q000097:blood / Q000633:toxicity*; D011507:Proteinuria / Q000139:chemically induced; D051381:Rats; D017208:Rats, Wistar; D051437:Renal Insufficiency / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology
chemical_list: D009566:Nitrates; D003404:Creatinine