A glycosidic isoflavonoid from Viola hondoensis W. BECKER et H. BOISSIEU (Violaceae), and its effect on the expression of matrix metalloproteinase-1 caused by ultraviolet irradiation in cultured human skin fibroblasts.
Isolation of the ethyl acetate soluble fraction from aerial parts of Viola hondoensis W. BECKER et H. BOISSIEU yielded one major isoflavonoid glycoside, tectoridin-4'-O-beta-D-glucoside. The structure of the compound was certainly determined by chemical analyses, as well as 1D- and 2D-NMR spectroscopy. The compound exhibited potent inhibitory activity against the expression of matrix metalloproteinase-1 caused by UV-irradiation in cultured human skin fibroblasts.
Moon
Hyung In
HI
Department of Dermatology, Seoul National University College of Medicine, and Clinical Research Institute, Seoul National University Hospital, Korea. himun@snu.ac.kr
Lee
Joongku
J
Zee
Ok Pyo
OP
Chung
Jin Ho
JH
D000818:Animals; D002478:Cells, Cultured; D005347:Fibroblasts / Q000187:drug effects* / Q000201:enzymology / Q000528:radiation effects*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects / Q000502:physiology; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007529:Isoflavones / Q000302:isolation & purification / Q000494:pharmacology*; D020781:Matrix Metalloproteinase 1 / Q000096:biosynthesis* / Q000528:radiation effects; D061965:Matrix Metalloproteinase Inhibitors; D051379:Mice; D041681:NIH 3T3 Cells; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D014466:Ultraviolet Rays / Q000009:adverse effects*; D032413:Viola
D006027:Glycosides; D007529:Isoflavones; D061965:Matrix Metalloproteinase Inhibitors; D010936:Plant Extracts; D020781:Matrix Metalloproteinase 1