title: 'Green' methodology for efficient and selective benzoylation of nucleosides using benzoyl cyanide in an ionic liquid.
abstract: Benzoyl cyanide in the ionic liquid 1-methoxyethyl-3-methylimidazolium methanesulfonate has been employed as a 'green' alternative and mild reaction condition protocol to conventional pyridine-benzoyl chloride system for efficient and selective benzoylation of nucleosides (of both the ribo- and deoxyribo-series) at ambient temperatures. The use of benzoyl cyanide-ionic liquid combination has been successfully extended for highly efficient benzoylation of phenols, aromatic amines, benzyl alcohol, aliphatic diols, 3-aminophenol and 2-aminobenzylalcohol, which indicates the versatility of this benzoylating system.
authors.affiliation: Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India. ashokenzyme@yahoo.com
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Prasad
authors.forename: Vineet
authors.initials: V
authors.lastname: Kumar
authors.forename: Shashwat
authors.initials: S
authors.lastname: Malhotra
authors.forename: Vasulinga T
authors.initials: VT
authors.lastname: Ravikumar
authors.forename: Yogesh S
authors.initials: YS
authors.lastname: Sanghvi
authors.forename: Virinder S
authors.initials: VS
authors.lastname: Parmar
mesh_terms: D001565:Benzoates / Q000737:chemistry*; D003486:Cyanides / Q000737:chemistry*; D007477:Ions; D009682:Magnetic Resonance Spectroscopy; D009705:Nucleosides / Q000737:chemistry*
chemical_list: D001565:Benzoates; D003486:Cyanides; D007477:Ions; D009705:Nucleosides