[Effects of different light-dark cycle on learning and memory in mice].
OBJECTIVE
To study the effect of different light-dark cycles on learning and memory in mice.


METHODS
Seventy-two ICR mice were raised under different light-dark cycles including LD 5h/5h, LD 12h/12h and LD 22h/22h for 6 weeks. The locomotor activity was recorded continuously. Morris water-maze task was used as the judging criteria for spatial learning and memory.


RESULTS
The locomotor activity rhythm was consistent with the light-dark cycle. The period of light-dark cycle shorter than 24 h such as 10 h could effect on the ability of learning and memory in mice.


CONCLUSIONS
The short period of light-dark cycle can improve the ability of learning and memory in mice.
Liu
Yan-you
YY
Yang
Bo
B
Jiang
Zhou
Z
Guo
Li
L
Wang
Yue-qi
YQ
Wang
Zheng-rong
ZR
D000818:Animals; D001522:Behavior, Animal / Q000528:radiation effects*; D003624:Darkness; D007858:Learning / Q000528:radiation effects*; D008027:Light; D018782:Maze Learning / Q000528:radiation effects; D008568:Memory / Q000528:radiation effects*; D051379:Mice; D008813:Mice, Inbred ICR; D017440:Photoperiod; D012153:Retention, Psychology / Q000528:radiation effects