title: Identification of antitumor activity of pyrazole oxime ethers.
abstract: A series of pyrazole oxime ether derivatives were prepared and examined as cytotoxic agents. In particular, 5-phenoxypyrazole was comparable to doxorubicin, while exhibiting very potent cytotoxicity against XF 498 and HCT15.
authors.affiliation: Bio-Organic Science Division, Korea Research Institute of Chemical Technology, PO Box 107, Yusong, Taejon 305-600, Republic of Korea.
authors.forename: Hyun-Ja
authors.initials: HJ
authors.lastname: Park
authors.forename: Kyung
authors.initials: K
authors.lastname: Lee
authors.forename: Su-Jin
authors.initials: SJ
authors.lastname: Park
authors.forename: Bangle
authors.initials: B
authors.lastname: Ahn
authors.forename: Jong-Cheol
authors.initials: JC
authors.lastname: Lee
authors.forename: Heeyeong
authors.initials: H
authors.lastname: Cho
authors.forename: Kee-In
authors.initials: KI
authors.lastname: Lee
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004987:Ethers; D006801:Humans; D020128:Inhibitory Concentration 50; D010091:Oximes; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D004987:Ethers; D010091:Oximes; D011720:Pyrazoles