Epstein-Barr virus BZLF1 protein binds to mitotic chromosomes.
Epstein-Barr virus (EBV) is a human herpesvirus that causes infectious mononucleosis and is associated with several types of cancers, including nasopharyngeal carcinoma and Burkitt's lymphoma. An EBV protein that plays an integral role during lytic replication is the immediate-early protein BZLF1. Our laboratory has found that BZLF1 (Z) localizes to host chromosomes during mitosis. Two Z-interacting proteins are also found localized to mitotic chromosomes in the presence of Z. The association between Z and mitotic chromosomes may lead to the sequestering of Z-interacting proteins within the cell and potentially cause an alteration of chromosome compaction or chromatin structure.
Adamson
Amy L
AL
Department of Biology, University of North Carolina at Greensboro, Greensboro, NC 27402, USA. aladamso@uncg.edu
D000818:Animals; D050882:CREB-Binding Protein; D002877:Chromosomes, Human / Q000378:metabolism; D033481:Chromosomes, Mammalian / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D008938:Mitosis; D041681:NIH 3T3 Cells; D009687:Nuclear Proteins / Q000378:metabolism; D051757:PAX5 Transcription Factor; D015534:Trans-Activators / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism; D014162:Transfection; D014764:Viral Proteins / Q000378:metabolism*
C063676:BZLF1 protein, Herpesvirus 4, Human; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D051757:PAX5 Transcription Factor; C497281:PAX5 protein, human; C497282:Pax5 protein, mouse; D015534:Trans-Activators; D014157:Transcription Factors; D014764:Viral Proteins; D050882:CREB-Binding Protein; C494363:CREBBP protein, human; C494364:Crebbp protein, mouse