Haplotype-based genetics in mice and rats.
Haplotype blocks are conceptually defined as genomic segments harbouring sets of coupled polymorphisms that reflect a common ancestral origin. Experimentally, however, haplotype blocks are characterized using computational algorithms based on incomplete inventories of polymorphisms. Haplotype blocks and their deduced strain-distribution patterns are considered to be extremely powerful for use in genetic association and mapping experiments in laboratory mice and rats. However, recent high-density SNP screening in commonly used mouse inbred strains reveals a complex pattern, suggesting that the current expectations for the use of haplotype blocks in genetic mapping will have to be revisited.
Cuppen
Edwin
E
Hubrecht Laboratory, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands. ecuppen@niob.nkaw.nl
D000465:Algorithms; D000818:Animals; D033481:Chromosomes, Mammalian / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes; D051379:Mice / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D051381:Rats / Q000235:genetics*