The current status of treatment for large meniscal defects.
Meniscal pathology causing loss of function is a common problem that requires treatment in a large number of individuals each year. A patient with a meniscal-deficient knee is doomed to the development of osteoarthritis, pain, and knee dysfunction. The amount, shape, and composition of meniscal tissue influence its function and, therefore, influence the health of the knee joint. When preservation of healthy meniscal tissue cannot be accomplished, methods for replacement or regeneration of meniscal tissue are necessary. This review article will discuss current methods of meniscal tissue replacement and regeneration and potential future modes of therapy.
Cook
James L
JL
University of Missouri Comparative Orthopaedic Laboratory, 379 E. Campus Drive, Columbia, MO 65211, USA. cookjl@missouri.edu
D000818:Animals; D001696:Biomechanical Phenomena; D002986:Clinical Trials as Topic; D006801:Humans; D008592:Menisci, Tibial / Q000473:pathology* / Q000601:surgery* / Q000637:transplantation*; D014184:Transplantation, Homologous; D014945:Wound Healing / Q000502:physiology