title: Hantavirus nucleocapsid protein: a multifunctional molecule with both housekeeping and ambassadorial duties.
abstract: In recent years important progress has been made studying the nucleocapsid (N) protein of hantaviruses. The N protein presents a good example of a multifunctional viral macromolecule. It is a major structural component of a virion that encapsidates viral RNA (vRNA). It also interacts with the virus polymerase (L protein) and one of the glycoproteins. On top of these "house keeping" duties, the N protein performs interactive "ambassadorial" functions interfering with important regulatory pathways in the infected cells.
authors.affiliation: Department of Virology, Haartman Institute, University of Helsinki, Finland.
authors.forename: P
authors.initials: P
authors.lastname: Kaukinen
authors.forename: A
authors.initials: A
authors.lastname: Vaheri
authors.forename: A
authors.initials: A
authors.lastname: Plyusnin
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism; D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D017209:Apoptosis; D036022:Capsid Proteins / Q000378:metabolism / Q000502:physiology*; D002352:Carrier Proteins / Q000378:metabolism; D056970:Co-Repressor Proteins; D019281:Dimerization; D019204:GTP-Binding Proteins / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism; D006476:Orthohantavirus / Q000737:chemistry / Q000502:physiology; D018778:Hantavirus Infections / Q000821:virology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D008958:Models, Molecular; D018832:Molecular Chaperones; D064547:Myxovirus Resistance Proteins; D009687:Nuclear Proteins / Q000378:metabolism; D011485:Protein Binding; D012324:RNA-Dependent RNA Polymerase / Q000378:metabolism; D014758:Viral Core Proteins / Q000378:metabolism / Q000502:physiology*; D014764:Viral Proteins / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D036022:Capsid Proteins; D002352:Carrier Proteins; D056970:Co-Repressor Proteins; C106985:DAXX protein, human; D006023:Glycoproteins; D047908:Intracellular Signaling Peptides and Proteins; D018832:Molecular Chaperones; D064547:Myxovirus Resistance Proteins; D009687:Nuclear Proteins; D014758:Viral Core Proteins; D014764:Viral Proteins; C111782:nucleocapsid protein, Hantaan virus; C500570:L protein, hantavirus; D012324:RNA-Dependent RNA Polymerase; D019204:GTP-Binding Proteins