title: New pregnane glycosides from Caralluma dalzielii.
abstract: Twenty-seven new pregnane glycosides were isolated from the whole plant of Caralluma dalzielii, and their structures elucidated from extensive 2D NMR analysis as well as ESI-MS experiments. All isolated compounds were tested for their antiproliferative activity on J774.A1, HEK-293, and WEHI-164 cell lines. Moderate to high potency of cytotoxicities were found in almost all tested compounds, confirming the significant cytotoxic activity of pregnane glycosides.
authors.affiliation: Dipartimento di Chimica Bioorganica e Biofarmacia, Università di Pisa, 56126 Pisa, Italy.
authors.forename: Marinella
authors.initials: M
authors.lastname: De Leo
authors.forename: Nunziatina
authors.initials: N
authors.lastname: De Tommasi
authors.forename: Rokia
authors.initials: R
authors.lastname: Sanogo
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Autore
authors.forename: Stefania
authors.initials: S
authors.lastname: Marzocco
authors.forename: Cosimo
authors.initials: C
authors.lastname: Pizza
authors.forename: Ivano
authors.initials: I
authors.lastname: Morelli
authors.forename: Alessandra
authors.initials: A
authors.lastname: Braca
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029062:Apocynaceae / Q000737:chemistry*; D002460:Cell Line; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D011278:Pregnanes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D010936:Plant Extracts; D011278:Pregnanes