title: [Effects of Naoyaojia on structural mechanical properties of femur in rats].
abstract: OBJECTIVE
  To study the effect of long term Naoyaojia administration on the structural mechanical properties of rat femurs.
  
  
  METHODS
  Young wistar rats were treated orally with Naoyaojia at doses of 3, 6, and 12 mg/kg body weight every 2 weeks for 1 year. Beary's bending test was used for determining physical properties of the femur.
  
  
  RESULTS
  The thickness of the cortex and cross-sectional area of femur increased significantly in animals treated with 3 mg/kg dose of Naoyaojia (P<0.01), significant increase in maximum bending load was also found in this group compared with the control group (P<0.01). But an opposite change was found in animals treated with 12 mg/kg dose of Naoyaojia.
  
  
  CONCLUSIONS
  Stimulation on the thickness of the cortex along the axis as well as the maximum bending load of femurs are found in animals treated with 3 mg/kg dose of Naoyaojia, but negative effects were observed at higher dose level.
authors.affiliation: Institute of Space Medico-Engineering, Beijing, China.
authors.forename: Xiao-chun
authors.initials: XC
authors.lastname: Shi
authors.forename: Zeng-yan
authors.initials: ZY
authors.lastname: Wu
authors.forename: Xi-he
authors.initials: XH
authors.lastname: Teng
authors.forename: Yu-min
authors.initials: YM
authors.lastname: Wan
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001846:Bone Development / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005269:Femur / Q000033:anatomy & histology / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004365:Drugs, Chinese Herbal