title: Clinical impact of late diagnose of bipolar disorder.
abstract: BACKGROUND
  This study assessed the impact of number of years undiagnosed (NYU) on current morbidity in patients with bipolar disorder.
  
  
  CONCLUSIONS
  The sample size used was rather small, which may make difficult the generalization of our findings to larger datasets. The data about age of onset and age when patients received their diagnosis may present a certain degree of recall error.
  
  
  METHODS
  Sixty-five bipolar outpatients diagnosed using the Structured Clinical Interview for DSM were included. The main outcome measurements were quality of life (QOL) assessed using the 26-item World Health Organization QOL instrument (WHOQOL-Bref) and depression assessed using the 17-item Hamilton Depression Rating Scale (HDRS).
  
  
  RESULTS
  Age of onset and years of disorder were not correlated with the outcomes assessed. The NYU were associated with higher scores of HDRS (P<0.01), lower scores of QOL within the physical (p<0.01) and psychological (p<0.05) domains of QOL.
  
  
  CONCLUSIONS
  Our findings suggest that the NYU may be an important predictor of the current clinical status of bipolar patients.
authors.affiliation: Psychiatry Research Unit, Post-Graduate Psychiatry Program, Federal University of Rio Grande Do Sul, Brazil.
authors.forename: Fernando Kratz
authors.initials: FK
authors.lastname: Gazalle
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Andreazza
authors.forename: Keila Maria
authors.initials: KM
authors.lastname: Ceresér
authors.forename: Pedro Curi
authors.initials: PC
authors.lastname: Hallal
authors.forename: Aida
authors.initials: A
authors.lastname: Santin
authors.forename: Flávio
authors.initials: F
authors.lastname: Kapczinski
mesh_terms: D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D012720:Severity of Illness Index; D013997:Time Factors