title: The stacked ABR: a sensitive and specific screening tool for detecting small acoustic tumors.
abstract: The failure of standard ABR measures to detect small (< or =1 cm) acoustic tumors has led to the use of enhanced magnetic resonance imaging (MRI) as the standard to screen for small tumors. This study investigates the suitability of the stacked ABR as a sensitive screening alternative to MRI for small acoustic tumors (SATs). The objective of the study was to determine the sensitivity and specificity of the stacked ABR technique for detecting SATs. A total of 54 patients with acoustic tumors identified by MRI that were either < or =1 cm in size or undetected by standard ABR methods, irrespective of size, were studied. A control population of 78 nontumor normal-hearing subjects was also tested. For comparison, two standard ABR measures (IT5 and I-V delay) were also analyzed. The stacked ABR demonstrated 95% sensitivity and 88% specificity; 100% sensitivity was obtained at 50% specificity. Standard ABR measures were much poorer in detecting these tumors. In conclusion, the stacked ABR can be used as a sensitive, widely-available, cost-effective, and comfortable tool for screening SATs.
authors.affiliation: Department of Electrophysiology, House Ear Institute, Los Angeles, Calif. 90057, USA.
authors.forename: Manuel
authors.initials: M
authors.lastname: Don
authors.forename: Betty
authors.initials: B
authors.lastname: Kwong
authors.forename: Chiemi
authors.initials: C
authors.lastname: Tanaka
authors.forename: Derald
authors.initials: D
authors.lastname: Brackmann
authors.forename: Ralph
authors.initials: R
authors.lastname: Nelson
mesh_terms: D000293:Adolescent; D000328:Adult; D003362:Cost-Benefit Analysis; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000191:economics / Q000295:instrumentation*; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000175:diagnosis* / Q000191:economics; D011930:Reaction Time; D012680:Sensitivity and Specificity