title: Genome-wide analysis of gene expression in neuroblastomas detected by mass screening.
abstract: Neuroblastoma (NB) is the most common extracranial solid tumor of childhood and the third most common pediatric cancer. Although numerous factors including patient age, disease stage and genetic abnormalities have been shown to be predictive of outcome, the mechanisms responsible for the highly variable clinical behavior of this tumor remain largely unknown. In order to gain new insights into the biology of this tumor, we performed microarray analysis and compared the gene expression patterns of NB detected by mass screening, characterized by highly probable spontaneous regression, versus stage 4 NB with poor prognosis. The bioinformatics analysis revealed a set of 19 discriminatory genes that may play a significant role in the natural progression of the disease. Validation of these results and further mechanistic studies would shed new light on the biology of tumor progression, and provide new tools to predict clinical outcome in children with NB.
authors.affiliation: Human Genetics Department, bioMérieux SA, 69280 Marcy l'Etoile, France.
authors.forename: Alexander
authors.initials: A
authors.lastname: Krause
authors.forename: Valérie
authors.initials: V
authors.lastname: Combaret
authors.forename: Isabelle
authors.initials: I
authors.lastname: Iacono
authors.forename: Bruno
authors.initials: B
authors.lastname: Lacroix
authors.forename: Christelle
authors.initials: C
authors.lastname: Compagnon
authors.forename: Christophe
authors.initials: C
authors.lastname: Bergeron
authors.forename: Sandrine
authors.initials: S
authors.lastname: Valsesia-Wittmann
authors.forename: Philippe
authors.initials: P
authors.lastname: Leissner
authors.forename: Bruno
authors.initials: B
authors.lastname: Mougin
authors.forename: Alain
authors.initials: A
authors.lastname: Puisieux
mesh_terms: D002675:Child, Preschool; D019295:Computational Biology; D018450:Disease Progression; D005260:Female; D020869:Gene Expression Profiling; D016678:Genome; D006801:Humans; D007120:Immunochemistry; D007223:Infant; D008297:Male; D008403:Mass Screening; D009447:Neuroblastoma / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis