title: The self-setting properties and in vitro bioactivity of tricalcium silicate.
abstract: In this study, tricalcium silicate (Ca(3)SiO(5)), as a new promising injectable bioactive material, was employed to investigate its physical and chemical properties for an injectable bioactive cement filler. The workable Ca(3)SiO(5) pastes with a liquid to powder (L/P) ratio of 0.8--.2 mlg(-1)could be injected for 15--60 min (nozzle diameter 2.0mm). The setting process yielded cellular structures with compressive strength of 6.4--20.2 MPa after 2--28 days. The in vitro bioactivity of Ca(3)SiO(5) paste was investigated by soaking in simulated body fluid (SBF) for various periods. The result showed that the Ca(3)SiO(5) paste could induce hydroxyapatite (HA) formation and dissolve slowly in SBF. The result of indirect cytotoxicity evaluation indicated that Ca(3)SiO(5) paste had a stimulatory effect on cell growth in a certain concentration range. The exothermic process showed that Ca(3)SiO(5) had lower heat evolution rate during the hydration as compared to calcium phosphate cement (CPC). Our results indicated that Ca(3)SiO(5) paste was bioactive and dissolvable, and it is a progressive candidate for further investigation as injectable tissue repairing substitute.
authors.affiliation: Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, the People's Republic of China.
authors.forename: Wenyuan
authors.initials: W
authors.lastname: Zhao
authors.forename: Junying
authors.initials: J
authors.lastname: Wang
authors.forename: Wanyin
authors.initials: W
authors.lastname: Zhai
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.forename: Jiang
authors.initials: J
authors.lastname: Chang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry* / Q000494:pharmacology*; D001826:Body Fluids / Q000737:chemistry*; D001843:Bone Cements / Q000032:analysis / Q000737:chemistry* / Q000494:pharmacology*; D017610:Calcium Compounds / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry* / Q000494:pharmacology*; D002478:Cells, Cultured; D019245:Compressive Strength; D003460:Crystallization / Q000379:methods*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D006244:Hardness; D007267:Injections; D008422:Materials Testing; D051379:Mice; D017640:Silicates / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry* / Q000494:pharmacology*; D012995:Solubility; D013499:Surface Properties; D014783:Viscosity
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D017610:Calcium Compounds; D017640:Silicates; C506393:tricalcium silicate