title: [Survey of the therapeutic reactions of CLONGAMMA in allergic rhinitis].
abstract: OBJECTIVE
  To evaluate the efficacy of IFN-gamma for treatment of allergic rhinitis.
  
  
  METHODS
  Sixty patients studied were divided into 2 groups randomly. The control group was given specific immunotherapy, the observe group was given specific immunotherapy and IFN-gamma treatment (1000000 IU im qod). Symptom score and level of serum IL-4 and ECP were compared pre and post treatment in two groups after 6 month.
  
  
  RESULTS
  In control group, the symptom score were 10.6 +/- 2.3 and 4.2 +/- 1.8 pre and post therapy, IL-4 were (545.3 +/- 86.2) ng/L and (320.4: +/- 76.3) ng/L, ECP were (24.3 +/- 8.2) microg/L and (12.4 +/- 6.3) microg/L. In observe group, the symptom score were 10.8 +/- 2.7 and 3.5 +/- 1.6 pre and post therapy, IL-4 were (547.8 +/- 84.6) ng/L and (280.4 +/- 87.3) ng/L, ECP were (25.1 +/- 7.7) microg/L and (10.4 +/- 5.1) microg/L. All the data P < 0.05. And after the therapy, there were significant difference in the observe group and the control group.
  
  
  CONCLUSIONS
  IFN-gamma may modulate the immune system and was effective in the treatment for allergic rhinitis.
authors.affiliation: Allergy Department, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Ghliu-3488@163.com
authors.forename: Guanghui
authors.initials: G
authors.lastname: Liu
authors.forename: Rongfei
authors.initials: R
authors.lastname: Zhu
authors.forename: Wenjing
authors.initials: W
authors.lastname: Li
authors.forename: Zhongxi
authors.initials: Z
authors.lastname: Wang
authors.forename: Aixia
authors.initials: A
authors.lastname: Huang
authors.forename: Huan
authors.initials: H
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D047150:Eosinophil Cationic Protein / Q000097:blood; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000627:therapeutic use*; D015847:Interleukin-4 / Q000097:blood; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D012221:Rhinitis, Allergic, Perennial / Q000097:blood / Q000628:therapy*
chemical_list: D011994:Recombinant Proteins; D015847:Interleukin-4; D007371:Interferon-gamma; D047150:Eosinophil Cationic Protein