Synthesis, properties and controlled release behaviors of hydrogel networks using cyclodextrin as pendant groups.
Based on inclusion character of beta-cyclodextrin (beta-CD) with drug molecule and low glass transition temperature of poly(2-hydroxyethyl acrylate) (PHEA), a series of hydrogels with different compositions were synthesized by the copolymerization of a monovinyl cyclodexrin monomer with 2-hydroxyethyl acrylate (HEA). The structure and properties of the hydrogels were characterized by FTIR, DSC, TGA and swelling measurements. It is found that swelling ratios of these beta-CD hydrogels can keep a relative stability in the range of pH from 1.4 to 7.4, and are not sensitive to change in NaCl concentration. Using drug N-acety-5-methoxytryptamine (melatonin, MEL) as a model molecule, the controlled drug release behaviors of these hydrogels were investigated. The results indicate that the diffusion and permeation of MEL from the hydrogels may be a dominant factor for its release. Owing to the formation of MEL/beta-CD retarding diffusion rate of MEL, a sustained release of MEL from hydrogel with high content of beta-CD can be obtained compared with hydrogel PHEA without beta-CD.
Liu
Yu-Yang
YY
Department of Applied Chemistry, School of Science, Northwestern Polytechnic University, Xi'an, 710072, People's Republic of China. yyliu666@yahoo.com.cn
Fan
Xiao-Dong
XD
D000042:Absorption; D000179:Acrylates / Q000032:analysis* / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000032:analysis / Q000737:chemistry*; D004058:Diffusion; D020100:Hydrogels / Q000032:analysis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D008550:Melatonin / Q000008:administration & dosage* / Q000737:chemistry*; D008968:Molecular Conformation
D000179:Acrylates; D003505:Cyclodextrins; D003692:Delayed-Action Preparations; D020100:Hydrogels; C035957:2-hydroxyethyl acrylate; D008550:Melatonin