title: Structure-retention relationship in a series of chiral 1,4-disubstituted piperazine derivatives on carbohydrate chiral stationary phases.
abstract: New racemic 1,4-disubstituted piperazines chemically named ethyl 2-[(4-pyrimidin-2yl-piperazine-1yl)carbonyl]C3-C5-alkanoates 1-7 were synthesized. The compounds were resolved into enantiomers on cellulose tris(4-methylbenzoate) and amylose tris(3,5-dimethylphenylcarbamate) stationary phases using hexane/propan-2-ol mobile phases. The optimum separation conditions for the compounds were obtained on cellulose tris(4-methylbenzoate) with 5% of 2-propanol in hexane. The relationship between structural and chromatographic parameters is discussed.
authors.affiliation: Institute of Chemistry, University of Białystok, Piłsudskiego 11/4, 15-443 Białystok, Poland.
authors.forename: Zdzisław
authors.initials: Z
authors.lastname: Chilmonczyk
authors.forename: Lukasz
authors.initials: L
authors.lastname: Sienicki
authors.forename: Bozena
authors.initials: B
authors.lastname: Lozowicka
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Lisowska-Kuźmicz
authors.forename: Anna
authors.initials: A
authors.lastname: Jończyk
authors.forename: Hassan Y
authors.initials: HY
authors.lastname: Aboul-Enein
mesh_terms: D000688:Amylose / Q000031:analogs & derivatives / Q000032:analysis / Q000737:chemistry; D002241:Carbohydrates / Q000032:analysis / Q000737:chemistry*; D002482:Cellulose / Q000031:analogs & derivatives / Q000032:analysis / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D015394:Molecular Structure; D048448:Phenylcarbamates / Q000032:analysis / Q000737:chemistry; D010879:Piperazines / Q000032:analysis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D002241:Carbohydrates; D048448:Phenylcarbamates; D010879:Piperazines; C080033:Chiralpak AD; D002482:Cellulose; D000688:Amylose