title: The synthesis of substituted bipiperidine amide compounds as CCR3 ligands: antagonists versus agonists.
abstract: Structure-activity relationship study of bipiperidine amide 1 has identified the reverse bipiperidine amide 4a as a CC chemokine-3 (CCR3) receptor antagonist. Optimization of the structure-activity relationship of compound 4a has resulted in the identification of a CCR3 antagonist 4i as well as a CCR3 agonist 13.
authors.affiliation: Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. pauline.ting@spcorp.com
authors.forename: Pauline C
authors.initials: PC
authors.lastname: Ting
authors.forename: Shelby P
authors.initials: SP
authors.lastname: Umland
authors.forename: Robert
authors.initials: R
authors.lastname: Aslanian
authors.forename: Jianhua
authors.initials: J
authors.lastname: Cao
authors.forename: Charles G
authors.initials: CG
authors.lastname: Garlisi
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.forename: James
authors.initials: J
authors.lastname: Jakway
authors.forename: Zhidan
authors.initials: Z
authors.lastname: Liu
authors.forename: Himanshu
authors.initials: H
authors.lastname: Shah
authors.forename: Fang
authors.initials: F
authors.lastname: Tian
authors.forename: Yuntao
authors.initials: Y
authors.lastname: Wan
authors.forename: Neng-Yang
authors.initials: NY
authors.lastname: Shih
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology*; D054413:Chemokine CCL11; D019742:Chemokines, CC / Q000378:metabolism; D002631:Chemotactic Factors, Eosinophil / Q000378:metabolism; D016244:Guanosine 5'-O-(3-Thiotriphosphate) / Q000378:metabolism; D006801:Humans; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D011485:Protein Binding; D054397:Receptors, CCR3; D019707:Receptors, Chemokine / Q000819:agonists* / Q000037:antagonists & inhibitors*; D015728:Receptors, HIV / Q000819:agonists / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; C515456:CCL11 protein, human; C515350:CCR3 protein, human; D054413:Chemokine CCL11; D019742:Chemokines, CC; D002631:Chemotactic Factors, Eosinophil; D010880:Piperidines; D054397:Receptors, CCR3; D019707:Receptors, Chemokine; D015728:Receptors, HIV; D016244:Guanosine 5'-O-(3-Thiotriphosphate)