[Placental expression of human histocompatibility antigen-G mRNA in idiopathic fetal growth restriction and its relationship with pathological changes of placenta].
OBJECTIVE
To investigate the expressions of human histocompatibility antigen-G (HLA-G) mRNA in placenta of idiopathic fetal growth restriction (IFGR) and its relationship with pathogenesis of IFGR.


METHODS
In situ hybridization was used to investigate the expression level and distribution of HLA-G mRNA in placentas of 20 cases of idiopathic IFGR and 28 cases of control group. HE stain was applied to observe the pathological changes of the placenta.


RESULTS
(1) The incidence of placental pathological lesions in idiopathic IFGR (75%) was notably higher than those of the control group (18%), (chi2 = 15.67, P = 0.001). (2) In situ hybridization showed the positive expression rate of HLA-G mRNA in placenta of idiopathic IFGR was 45%, that of control group was 79%, with significant difference between the two groups (chi2 = 5.75, P = 0.017). HLA-G mRNA signal mainly expressed in cytotrophoblast and syncytiotrophoblast. (3) There was negative correlation between the expression rate of HLA-G mRNA and incidence of placental pathological lesions (r = -0.638, P = 0.008).


CONCLUSIONS
There is a significant decrease in the expression of HLA-G mRNA in IFGR. HLA-G may play a role in the pathogenesis of IFGR.
Fan
Shu-Shu
SS
Department of Obstetrics and Gynecology, Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510120, China.
Zhang
Jian-Ping
JP
Shao
Jian-Yong
JY
Tan
Jian-Ping
JP
Liu
Yu-Kun
YK
Wang
Yun-Hui
YH
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D047109:Fetal Development; D005317:Fetal Growth Retardation / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D005786:Gene Expression Regulation; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010920:Placenta / Q000276:immunology / Q000473:pathology*; D011247:Pregnancy; D055815:Young Adult
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I