Population pharmacokinetics of abacavir in plasma and cerebrospinal fluid.
The distribution of abacavir into the cerebrospinal fluid (CSF) was assessed by use of a population pharmacokinetic analysis. Plasma and CSF abacavir concentrations in 54 subjects were determined. The abacavir CSF/plasma ratio averaged 36% and increased throughout the dose interval. Abacavir penetrates into the CSF in adequate concentrations to inhibit local human immunodeficiency virus replication.
Capparelli
Edmund V
EV
Pediatric Pharmacology Research Unit (PPRU), University of California, San Diego, 200 West Arbor Drive, MC 8214, San Diego, CA 92103-8214, USA. ecapparelli@ucsd.edu
Letendre
Scott L
SL
Ellis
Ronald J
RJ
Patel
Parul
P
Holland
Diane
D
McCutchan
J Allen
JA
D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000134:cerebrospinal fluid* / Q000493:pharmacokinetics*; D015224:Dideoxynucleosides / Q000008:administration & dosage / Q000134:cerebrospinal fluid* / Q000493:pharmacokinetics*; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D008297:Male; D008954:Models, Biological; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*; D012984:Software; D000099227:Abacavir
D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D018894:Reverse Transcriptase Inhibitors; D000099227:Abacavir