title: Antibacterial activity of dipropofol and related compounds.
abstract: Phenolic compounds, in general, exhibit antioxidant and antibacterial activities. We studied antimicrobial activity of the phenolic antioxidants, propofol (2,6-diisopropylphenol), tocopherol, eugenol, butylated hydroxyanisole (BHA), and several of their dimer compounds. Dipropofol (dimer of 2,6-diisopropylphenol) showed strong antibacterial activity against gram-positive strains including methicillin resistant Staphylococcus aureus (MRSA) and vancomycin resistant Enterococci (VRE), while propofol and other monomeric and dimeric phenols having methyl or tert-butyl groups showed no remarkable activity. The results indicated that the dimeric structure of 2,6-diisopropylphenol moiety may play an important role in the antibacterial activity.
authors.affiliation: Kyoritsu University of Pharmacy, Tokyo, Japan. ogata-ms@aomori-u..ac.jp
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ogata
authors.forename: Kanae
authors.initials: K
authors.lastname: Tutumimoto Sato
authors.forename: Takao
authors.initials: T
authors.lastname: Kunikane
authors.forename: Kentaro
authors.initials: K
authors.lastname: Oka
authors.forename: Masako
authors.initials: M
authors.lastname: Seki
authors.forename: Shiro
authors.initials: S
authors.lastname: Urano
authors.forename: Keiichi
authors.initials: K
authors.lastname: Hiramatsu
authors.forename: Toyoshige
authors.initials: T
authors.lastname: Endo
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods; D015742:Propofol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development
chemical_list: D000900:Anti-Bacterial Agents; D015742:Propofol