Multicentric reticulohistiocytosis presenting with papulonodular skin eruption and polyarthritis.
Multicentric reticulohistiocytosis is a rare multisystem disease, presenting with skin lesions and erosive polyarthritis, which is often associated with malignancy. A 2 year untreated natural course of multicentric reticulohistiocytosis, in which the typical nodular skin manifestation of the disease and polyarticular arthritis was present, is described in a 34-year-old lady with no history of major medical disease. Histopathology showed the characteristic histiocytic and multinucleated giant cell infiltrate with ground glass cytoplasm. Massive destruction of articular surfaces and new papular skin lesions accompanied by atrophic scars of previous skin lesions developed after 2 years of untreated active disease.
Baghestani
Shahram
S
Hormozgan University of Medical Sciences, Bandar Abbas Medical School, Department of Dermatology, PO Box 79145-3654, Bandar Abbas, Iran. sbaghestani@yahoo.com
Khosravi
Farrokh
F
Dehghani Zahedani
Mohsen
M
Mahboobi
Abdol-Ali
AA
D000328:Adult; D001168:Arthritis / Q000175:diagnosis* / Q000188:drug therapy; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D015616:Histiocytosis, Non-Langerhans-Cell / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging / Q000379:methods; D018570:Risk Assessment; D012720:Severity of Illness Index; D012872:Skin Diseases, Vesiculobullous / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*