title: Natural product-like libraries based on non-aromatic, polycyclic motifs.
abstract: Diversity-oriented synthesis is an intriguing approach for creating structurally diverse compounds that cover the pharmaceutically relevant chemical space in an optimal way. On the other hand, an over-proportionally large number of drugs or lead structures originate from compounds isolated from natural sources. Thus, not surprisingly, an increasing number of combinatorial libraries are based on motifs resembling natural products. A particular aspect of many natural products is the presence of non-aromatic, polycyclic core structures. The fusion of several rings leads to geometrically well-defined structures and, thus, holds the promise of a high functional specialisation. In this review we present several actual examples of natural product-like libraries with non-aromatic polycyclic motifs based on naturally occurring compounds.
authors.affiliation: Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012 Bern, Switzerland.
authors.forename: Roland
authors.initials: R
authors.lastname: Messer
authors.forename: Cyril A
authors.initials: CA
authors.lastname: Fuhrer
authors.forename: Robert
authors.initials: R
authors.lastname: Häner
mesh_terms: D001685:Biological Factors / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D016208:Databases, Factual; D015195:Drug Design; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000737:chemistry*
chemical_list: D001685:Biological Factors; D011083:Polycyclic Compounds