title: Implications of pouchitis on the functional results following stapled restorative proctocolectomy.
abstract: OBJECTIVE
  Pouchitis is the most frequent long-term complication of restorative proctocolectomy; its long-term consequences are inadequately described. This prospective study evaluates the effect of pouchitis on the functional results, general health perception, and patient satisfaction.
  
  
  METHODS
  A total of 100 consecutive patients who underwent stapled restorative proctocolectomy for ulcerative colitis were divided into three groups: no pouchitis, acute pouch-itis and chronic pouchitis. Functional results, general health perception, and satisfaction of each group at the latest review were compared only when patients were not symptomatic of active pouchitis.
  
  
  RESULTS
  Pouchitis occurred in 33 patients (17 acute and 16 chronic). There were no significant differences in the long-term functional results between the no pouchitis and acute pouchitis groups. Patients who experienced chronic pouchitis had a significant increase in bowel movements, looseness of stools, urgency, nocturnal seepage, perianal excoriation, and dietary restrictions (P < 0.05). They also had a worse perception of their general health (P < 0.05). Previous chronic pouchitis had no effect on continence, daytime soilage, or gas-feces discrimination. Most patients were satisfied, despite pouchitis, and would recommend the operation to someone else with ulcerative colitis.
  
  
  CONCLUSIONS
  Acute pouchitis is easily treated and results in minimal functional consequences. Even in the absence of clinically active pouchitis, patients who had suffered from chronic pouchitis had poorer functional results and general health perception. This may overshadow the benefits of restorative proctocolectomy. This finding suggests that acute and chronic pouchitis are distinct disease entities and chronic pouchitis may represent a persistent condition that displays episodic symptomatic exacerbation.
authors.affiliation: Colorectal Unit, Department of Surgery, York Hospital, UK. aymonrazeq@yahoo.co.uk
authors.forename: Ayman S
authors.initials: AS
authors.lastname: Abdelrazeq
authors.forename: Jonathan N
authors.initials: JN
authors.lastname: Lund
authors.forename: Stephen H
authors.initials: SH
authors.lastname: Leveson
mesh_terms: D000208:Acute Disease; D000328:Adult; D016009:Chi-Square Distribution; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D017060:Patient Satisfaction; D019449:Pouchitis / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D016737:Proctocolectomy, Restorative / Q000009:adverse effects*; D011446:Prospective Studies; D012307:Risk Factors; D013537:Sutures