The antigenic tip GPGRAFY of the V3 loop on HIV-1 gp120: genetic variability and subtypes.
V3 loop on HIV-1 gp120 is tightly correlated with syncytium formation, coreceptor usage, virus infectivity and antibody neutralization. The antigenic tip GPGRAFY with its flanking sequence has a conserved secondary structure, and is the target of neutralizing antibodies. We analyzed its genetic variability in 30096 M-group isolates and 269 O-group isolates. Subtype-related restricted mutations were observed, which could help to identify subtypes.
Dong
Xiao-Nan
XN
Laboratory of Immunology, Department of Biology, Tsinghua University, Protein Science Laboratory of MOE, Beijing 100084, PR China. xndong00@mails.tsinghua.edu.cn
Wu
Yi
Y
Ying
Jian
J
Chen
Ying-Hua
YH
D020816:Amino Acid Motifs / Q000235:genetics / Q000276:immunology; D000939:Epitopes / Q000145:classification / Q000235:genetics* / Q000276:immunology*; D014644:Genetic Variation; D015699:HIV Envelope Protein gp120 / Q000145:classification / Q000235:genetics* / Q000276:immunology*; D015497:HIV-1 / Q000145:classification / Q000235:genetics* / Q000276:immunology*
D000939:Epitopes; D015699:HIV Envelope Protein gp120