A new origin for chartreusin.
Unraveling the sequence of reactions that transforms aromatic polyketide backbones into much more elaborate structures, for example the chartreusin bislactone, is challenging, but in this issue of Chemistry & Biology, Xu and coworkers [1] show that sequencing the gene clusters can provide valuable clues.
Weissman
Kira
K
Department of Biochemistry, University of Cambridge, United Kingdom.
D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D001578:Benzopyrans; D006027:Glycosides / Q000096:biosynthesis; D007783:Lactones / Q000378:metabolism; D048630:Polyketide Synthases / Q000378:metabolism*; D013302:Streptomyces / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; D001578:Benzopyrans; D006027:Glycosides; D007783:Lactones; C069755:chartarin; D048630:Polyketide Synthases; C002185:chartreusin