Establisment of a novel pig model of pancreatoduodenal allotransplantation.
BACKGROUND
Pancreas transplantation is a valid therapy for patients with type 1 diabetes mellitus (IDDM). This study was undertaken to establish a stable pig model of whole pancreatoduodenal allotransplantation of physiologically coincidence for pancreas transplantation.


METHODS
The IDDM pig model was made by resection of the pancreas from the recipient. The portal vein of the donor was end-to-side anastomosed to the anterior mesenteric vein (equal to the superior mesenteric vein) or the portal vein of the recipient. The far end of the celiac axis was anastomosed to each other. With end-to-side fashion, the duodenum of the donor was anastomosed to the jejunum of the recipient.


RESULTS
In 16 transplantations, results were satisfactory. The anatomical results and immune function including the function of the pancreas were similar to those of human being.


CONCLUSIONS
Of the pancreas of the pig, this study of pancreatic transplantation shows that the novel pig whole pancreatoduodenal allotransplantation model is ideal.
Li
Jian-Shui
JS
Department of General Surgery,West China Hospital,Sichuan University,Chengdu 610041, China.
Tang
Yong
Y
Wei
Jiang-Tao
JT
Zhang
Zhao-Da
ZD
D000714:Anastomosis, Surgical; D000818:Animals; D001707:Biopsy, Needle; D004386:Duodenum / Q000601:surgery; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D007150:Immunohistochemistry; D007583:Jejunum / Q000601:surgery; D008297:Male; D023421:Models, Animal; D010179:Pancreas / Q000601:surgery; D016035:Pancreas Transplantation / Q000009:adverse effects / Q000379:methods* / Q000473:pathology*; D012680:Sensitivity and Specificity; D013552:Swine; D014184:Transplantation, Homologous