[A study of cytomegalovirus (CMV) glycoprotein B genotypes in patients with CMV infection after hematopoietic stem cell transplantation].
OBJECTIVE
To study the different cytomegalovirus (CMV) glycoprotein (G) B genotypes in the patients with CMV infection after hematopoietic stem cell transplantation (HSCT) and the correlation between genotype and pathogenesis of CMV disease.


METHODS
Thirty-eight patients received allogenetic from March 2001 to December 2003. CMV GB DNA was detected with nested-PCR in all the patients and the products were digested with RsaI and HinfI.


RESULTS
The distribution of GB types were as follows: GB1, 19/38 (50.0%); GB2, 3/38 (7.9%), GB3, 14/38 (36.8%). GB1 was associated with favorable clinical outcome, while GB3 might contribute to fatal interstitial pneumonia (IP). The incidences of graft versus host disease (GVHD) were not different significantly between the patients with GB1 and those with GB3.


CONCLUSIONS
CMV GB genotypes might play an important role in the pathogenesis of CMV-IP, but not of GVHD.
Wu
Xiao-jin
XJ
Department of Hematology, the First Affiliated Hospital, Soochow University, Suzhou 215006, China.
Wu
De-pei
DP
Sun
Ai-ning
AN
Ma
Xiao
X
Chang
Hui-rong
HR
Zhu
Zi-lin
ZL
D000293:Adolescent; D000328:Adult; D002648:Child; D003587:Cytomegalovirus / Q000235:genetics*; D003586:Cytomegalovirus Infections / Q000821:virology*; D004279:DNA, Viral / Q000097:blood; D005260:Female; D005838:Genotype; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D014759:Viral Envelope Proteins / Q000235:genetics*
D004279:DNA, Viral; D014759:Viral Envelope Proteins; C040495:glycoprotein B, Simplexvirus