Recombinant cysteine proteinase from Leishmania (Leishmania) chagasi implicated in human and dog T-cell responses.
High in vitro lymphoproliferative responses were induced in humans and dogs by a recombinant Leishmania (Leishmania) chagasi cysteine proteinase, with secretion of IFN-gamma in asymptomatic subjects or of IFN-gamma, interleukin 4 (IL-4), and IL-10 in oligosymptomatic subjects. In contrast, responses of symptomatic patients and dogs were lower, with production of IL-4 and IL-10.
da Costa Pinheiro
Paulo Henrique
PH
Division of Parasitology, Universidade Federal de São Paulo, Escola Paulista de Medicina, Rua Botucatu, 862-6o andar, São Paulo, SP, Brazil 04023-062.
de Souza Dias
Suzana
S
Eulálio
Kelsen Dantas
KD
Mendonça
Ivete L
IL
Katz
Simone
S
Barbiéri
Clara Lúcia
CL
D000818:Animals; D003546:Cysteine Endopeptidases / Q000494:pharmacology*; D004285:Dogs; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D016753:Interleukin-10 / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D018314:Leishmania infantum / Q000201:enzymology* / Q000276:immunology; D007898:Leishmaniasis, Visceral / Q000276:immunology*; D008213:Lymphocyte Activation; D015800:Protozoan Proteins / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology*
D015800:Protozoan Proteins; D011994:Recombinant Proteins; D016753:Interleukin-10; D015847:Interleukin-4; D007371:Interferon-gamma; D003546:Cysteine Endopeptidases; C111469:Ldccys1 protein, Leishmania chagasi