title: Quantitative evaluation of renal function in healthy Beagle puppies and mature dogs.
abstract: Daily urinary collection and assessment of glomerular filtration rate (GFR) and effective renal plasma flow were performed in ten 2-month-old Beagle puppies and ten 6-9 year-old Beagle dogs to identify age-associated differences in renal function. The most striking differences in puppies compared to mature dogs were a higher daily urinary volume (+65%), GFR (+87%), free water reabsorption (+159%), a lower daily protein excretion (-88%), and fractional excretion of phosphorus (-35%). Renal function in Beagle puppies, but not mature dogs, was also quite different compared to data published in younger adult dogs.
authors.affiliation: UMR 181 Physiopathologie et Toxicologie Expérimentales INRA/ENVT, Ecole Nationale Vétérinaire de Toulouse, 23 chemin des Capelles, 31076 Toulouse cedex 03, France.
authors.forename: V
authors.initials: V
authors.lastname: Laroute
authors.forename: V
authors.initials: V
authors.lastname: Chetboul
authors.forename: L
authors.initials: L
authors.lastname: Roche
authors.forename: C
authors.initials: C
authors.lastname: Maurey
authors.forename: G
authors.initials: G
authors.lastname: Costes
authors.forename: J-L
authors.initials: JL
authors.lastname: Pouchelon
authors.forename: F
authors.initials: F
authors.lastname: De La Farge
authors.forename: M
authors.initials: M
authors.lastname: Boussouf
authors.forename: H P
authors.initials: HP
authors.lastname: Lefebvre
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D002118:Calcium / Q000652:urine; D002713:Chlorine / Q000652:urine; D003404:Creatinine / Q000652:urine; D004285:Dogs / Q000502:physiology* / Q000652:urine; D005260:Female; D007668:Kidney / Q000502:physiology*; D007677:Kidney Function Tests / Q000662:veterinary; D008297:Male; D010758:Phosphorus / Q000652:urine; D011188:Potassium / Q000652:urine; D012016:Reference Values; D012964:Sodium / Q000652:urine; D016482:Urinalysis / Q000662:veterinary
chemical_list: D010758:Phosphorus; D002713:Chlorine; D012964:Sodium; D003404:Creatinine; D011188:Potassium; D002118:Calcium