title: Radiation-induced mandibular osteogenic sarcoma: report of a case and review of the literature.
abstract: The case of a 56-year-old man with osteogenic sarcoma of the mandible diagnosed 7 years after radiotherapy treatment of a laryngeal cancer is reported. Surgery was the initial treatment. The progress was poor after local and pulmonary relapse, without response to chemotherapy treatment. Radiation-induced sarcomas are uncommon tumors that are diagnosed by meeting some diagnostic criteria. The mandible is a location very sensitive to radiation effects. The authors have found in the literature 30 cases of mandibular radiation-induced osteogenic sarcomas, most of them secondary to treatment of benign lesions, none of them secondary to treatment of a laryngeal cancer, as was seen in their case.
authors.affiliation: Medical Oncology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. vvalenti@grupsagessa.com
authors.forename: Vicente
authors.initials: V
authors.lastname: Valentí
authors.forename: Antonio
authors.initials: A
authors.lastname: López-Pousa
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Gonzalez
authors.forename: Nuria
authors.initials: N
authors.lastname: Farré
mesh_terms: D001932:Brain Neoplasms / Q000556:secondary; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy; D016371:Cranial Irradiation / Q000009:adverse effects*; D017809:Fatal Outcome; D006801:Humans; D007822:Laryngeal Neoplasms / Q000532:radiotherapy; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D008339:Mandibular Neoplasms / Q000209:etiology*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009381:Neoplasms, Radiation-Induced / Q000601:surgery*; D012516:Osteosarcoma / Q000209:etiology*