The effect of prepartum antibiotics on the type of neonatal bacteraemia: insights from the MRC ORACLE trials.
We analysed the type of bacteraemia before discharge from Neonatal Intensive Care Units in babies born to women randomised to the MRC ORACLE Trials. There was no evidence for an effect of oral antibiotics given prior to delivery on bacteraemia due to gram negative or enterococci bacteria, but Group B streptococcal (GBS) bacteraemia was significantly reduced in women with preterm prelabour rupture of the membranes (1.58% to 0.55%, relative risk 0.34; 95% CI: 0.17-0.70). There was no detectable effect in women in spontaneous preterm labour with intact membranes as the risk of GBS bacteraemia in their babies was very small regardless of treatment.
Gilbert
R E
RE
Centre for Evidence-based Child Health, Institute of Child Health, London, UK.
Pike
K
K
Kenyon
S L
SL
Tarnow-Mordi
W
W
Taylor
D J
DJ
D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D016470:Bacteremia / Q000401:mortality / Q000517:prevention & control; D001424:Bacterial Infections / Q000517:prevention & control*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000382:microbiology; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000401:mortality / Q000517:prevention & control*; D015337:Multicenter Studies as Topic; D007752:Obstetric Labor, Premature / Q000382:microbiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000517:prevention & control*; D011295:Prenatal Care / Q000379:methods*; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors
D000900:Anti-Bacterial Agents