Is aggregated IAPP a cause of beta-cell failure in transplanted human pancreatic islets?
Aggregation of the beta-cell product islet amyloid polypeptide (IAPP) is believed to be an important event in the development of the beta-cell lesion in type 2 diabetes. Preamyloidotic oligomeric IAPP assemblies exert toxic effects on beta cells that die, leading to reduced beta-cell mass. Normal human islets, when isolated and cultured in vitro or transplanted into nude mice, also develop amyloid deposits, which are associated with increased beta-cell death and reduced beta-cell mass. The possible role of IAPP aggregation and amyloid formation in loss of islet transplant function should be taken into consideration and studied further.
Westermark
Per
P
Linköping University, Department of Biomedicine and Surgery, Cell Biology, 12, University Hospital, Linköping SE 581 85, Sweden. Per.Westermark@genpat.uu.se
Andersson
Arne
A
Westermark
Gunilla T
GT
D000682:Amyloid / Q000737:chemistry* / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D003924:Diabetes Mellitus, Type 2 / Q000473:pathology; D006801:Humans; D058228:Islet Amyloid Polypeptide; D007515:Islets of Langerhans / Q000473:pathology; D016381:Islets of Langerhans Transplantation / Q000473:pathology*; D017211:Treatment Failure
D000682:Amyloid; D058228:Islet Amyloid Polypeptide