title: The 825C/T polymorphism of G-protein beta3 subunit gene and risk of ischaemic stroke.
abstract: In this study, we investigated the association of G protein beta3 subunit gene (GNB 3) C825T polymorphism with ischaemic stroke and its subtypes in the Chinese Han population in a large case-control study. A total of 990 ischemic stroke patients and 1124 controls were recruited from six medical centres in China. Genotype was determined by polymerase chain reaction and restriction fragment length polymorphism (RFLP) assay. Logistic regression analysis was performed to identify the independent risk factors for stroke. The frequency of 825T carriers is significantly higher in cerebral thrombosis in male subjects (OR=1.35, 95% CI, 1.01-1.82, P=0.046). After further adjustment with traditional risk factors to stroke, the association is not significant. In conclusion, the GNB3 825T allele is not an independent risk factor to ischaemic stroke in the Chinese population.
authors.affiliation: Sino-German Laboratory for Molecular Medicine, Fu Wai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: K
authors.initials: K
authors.lastname: Sun
authors.forename: Y
authors.initials: Y
authors.lastname: Song
authors.forename: R
authors.initials: R
authors.lastname: Hui
authors.forename: X
authors.initials: X
authors.lastname: Huang
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D002545:Brain Ischemia / Q000235:genetics*; D016022:Case-Control Studies; D003596:Cytosine; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020521:Stroke / Q000235:genetics*; D013941:Thymine
chemical_list: C454420:G-protein beta3 subunit; D003596:Cytosine; D020962:Heterotrimeric GTP-Binding Proteins; D013941:Thymine