Early neural correlates of conscious somatosensory perception.
The cortical processing of consciously perceived and unperceived somatosensory stimuli is thought to be identical during the first 100-120 ms after stimulus onset. Thereafter, the electrophysiological correlates of conscious perception have been shown to be reflected in the N1 component of the evoked response as well as in later (>200 ms) nonstimulus-locked gamma-band (28-50 Hz) oscillatory activity. To evaluate more specifically the time course and correlation of neuronal oscillations with conscious perception, we recorded neuromagnetic responses to threshold-intensity somatosensory stimuli. We show here that cortical broadband activities phase locked to the subsequently perceived stimuli in somatosensory, frontal, and parietal regions as early as 30-70 ms from stimulus onset, whereas the phase locking to the unperceived stimuli was weak and primarily restricted to somatosensory regions. Such stimulus locking also preceded the perceived stimuli, indicating that the phase of ongoing cortical activities biases subsequent perception. Furthermore, the data show that the stimulus locking was present in the theta- (4-8 Hz), alpha- (8-14 Hz), beta- (14-28 Hz), and gamma- (28-40 Hz) frequency bands, of which the widespread alpha-band component was dominant for the consciously perceived stimuli but virtually unobservable for the unperceived stimuli. Our results show that the neural correlates of conscious perception are already found during the earliest stages of cortical processing from 30 to 150 ms after stimulus onset and suggest that alpha-frequency-band oscillations have a role in the neural mechanisms of sensory awareness.
Palva
Satu
S
BioMag Laboratory, Engineering Centre, Helsinki University Central Hospital, FIN-00029 Helsinki, Finland. satu.palva@helsinki.fi
Linkenkaer-Hansen
Klaus
K
Näätänen
Risto
R
Palva
J Matias
JM
D000328:Adult; D001931:Brain Mapping; D003243:Consciousness / Q000502:physiology*; D004307:Dose-Response Relationship, Radiation; D004558:Electric Stimulation / Q000379:methods; D004569:Electroencephalography / Q000379:methods; D005073:Evoked Potentials, Somatosensory / Q000502:physiology* / Q000528:radiation effects; D005260:Female; D007839:Functional Laterality; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods; D008297:Male; D010465:Perception / Q000502:physiology*; D011336:Probability; D011601:Psychophysics / Q000379:methods; D011930:Reaction Time / Q000502:physiology*; D013003:Somatosensory Cortex / Q000502:physiology*; D013223:Statistics as Topic; D013997:Time Factors