title: Bizarre parosteal osteochondromatous proliferation with a t(1;17) translocation.
abstract: Bizarre parosteal osteochondromatous proliferation (BPOP) is a benign lesion that tends to recur repeatedly. Histologically, BPOP contains three components (cartilage, bone, and spindle cells) in differing amounts. The histological findings of BPOP are similar to those of florid reactive periostitis (FRP) and subungual (Dupuytren's) exostosis. Some authors have postulated that all of these conditions are reactive proliferative lesions representing different phases of reactive processes. Whether BPOP is a reactive proliferative lesion or a neoplastic lesion, however, remains controversial. Recently, a t(1;17)(q32;q21) translocation in BPOP was detected using chromosome banding and fluorescence in situ hybridization (FISH) analyses. Here, we describe a 39-year-old Japanese female with BPOP arising in the proximal phalanx of her third toe. A cytogenetic analysis revealed a t(1;17)(q 42;q23) translocation. The breakpoints in this case are located close to those of previously reported cases. These results suggest that t(1;17) is a distinct translocation of BPOP and that BPOP is a neoplastic lesion, rather than a reactive proliferative process.
authors.affiliation: Division of Orthopaedic Oncology, National Cancer Centre Hospital and Research Institute, Tokyo, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Endo
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Tashiro
authors.forename: Umio
authors.initials: U
authors.lastname: Yamaguchi
authors.forename: Yuki
authors.initials: Y
authors.lastname: Morimoto
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Nakatani
authors.forename: Tadakazu
authors.initials: T
authors.lastname: Shimoda
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D049109:Cell Proliferation; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015831:Osteochondroma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D011859:Radiography; D032681:Spectral Karyotyping; D014034:Toes / Q000000981:diagnostic imaging / Q000473:pathology; D014178:Translocation, Genetic; D016896:Treatment Outcome