Influence of surfactant molecular structure on two-dimensional surfactant-DNA complexes: Langmuir balance study.
In this paper, we used two simplified methods to understand the influence of surfactant molecular structure on the properties of surfactant-DNA complexes. First, we selected Langmuir balance technique, a two-dimensional (2D) method, which allows complex formation under equilibrium-like conditions, avoiding some of the inherent problems involved in solution. Secondly, two series of simple quaternary ammonium surfactants were used. The cationic surfactant-DNA complex monolayers were formed at the air-water interface through the electrostatic interaction between the ammonium groups of the surfactants and the phosphate groups of DNA at the air-water interface. Combining the results of pi-A isotherms, pi-t isotherms, and atomic force microscopy (AFM) measurements, it was found that the surfactant molecular structures affect the surface properties and morphologies of 2D surfactant-DNA complexes. We expect that the study of the properties of 2D surfactant-DNA complexes will help us to understand the physicochemical properties of surfactant-DNA complexes, which are important for gene delivery.
Chen
Xiaodong
X
CAS Key Laboratory of Colloid and Interface Science, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, People's Republic of China.
Wang
Jinben
J
Liu
Minghua
M
D000538:Aluminum Silicates / Q000737:chemistry; D002412:Cations / Q000737:chemistry; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004247:DNA / Q000737:chemistry*; D046911:Macromolecular Substances / Q000737:chemistry; D018625:Microscopy, Atomic Force; D015394:Molecular Structure; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry*
D000538:Aluminum Silicates; D002412:Cations; D046911:Macromolecular Substances; D013501:Surface-Active Agents; D004247:DNA; C011934:mica