title: Caffeic acid metabolites from Eritrichium sericeum cell cultures.
abstract: Eritrichium sericeum (Boraginaceae) callus and root cultures were established and analyzed for caffeic acid metabolite (CAM) production. Two substances, (-)-rabdosiin and rosmarinic acid, were identified as main CAMs produced by these cultures. The E. sericeum Er-1 root culture accumulated up to 1.5 % and 4.5 % DW of (-)-rabdosiin and rosmarinic acid, respectively. Rabdosiin in the Lithospermum erythrorhizon callus cultures was produced exclusively as the (+)-enantiomer while in both Eritrichium cultures it occurred as the (-)-enantiomer. The E. sericeum Er-1 culture accumulated 3-fold higher levels of CAMs than the L. erythrorhizon culture. A new compound, named eritrichin, was isolated from the cultured E. sericeum cells. The structure of this compound was established as (2R)-3-(3,4-dihydroxyphenyl)-2-[4-(3,4-dihydroxyphenyl)-6,7-dihydroxy-2-naphthoyloxy]propanoic acid on the basis of spectral data.
authors.affiliation: Pacific Institute of Bioorganic Chemistry, Far East Branch of Russian Academy of Sciences, Vladivostok, Russian Federation. fedoreyev@mail.primorye.ru
authors.forename: Sergey A
authors.initials: SA
authors.lastname: Fedoreyev
authors.forename: Marina V
authors.initials: MV
authors.lastname: Veselova
authors.forename: Olga E
authors.initials: OE
authors.lastname: Krivoschekova
authors.forename: Natalia P
authors.initials: NP
authors.lastname: Mischenko
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Denisenko
authors.forename: Pavel S
authors.initials: PS
authors.lastname: Dmitrenok
authors.forename: Valery P
authors.initials: VP
authors.lastname: Glazunov
authors.forename: Victor P
authors.initials: VP
authors.lastname: Bulgakov
authors.forename: Galina K
authors.initials: GK
authors.lastname: Tchernoded
authors.forename: Yury N
authors.initials: YN
authors.lastname: Zhuravlev
mesh_terms: D028082:Boraginaceae / Q000737:chemistry / Q000378:metabolism*; D002109:Caffeic Acids / Q000737:chemistry / Q000378:metabolism*; D002478:Cells, Cultured; D006801:Humans; D008517:Phytotherapy; D018517:Plant Roots / Q000737:chemistry / Q000378:metabolism; D012639:Seeds / Q000737:chemistry / Q000378:metabolism
chemical_list: D002109:Caffeic Acids