Osteoporosis.
Bone is a complex organ which contains an organic matrix which serves as scaffolding, includes mineral as calcium distributed in a pattern providing structure and serves as an ion reservoir for the body. Throughout life it dynamically changes in response to changes in activity, body mass, and weight bearing. It is important to define patients at risk for bone loss, since accrued bone loss leading to osteoporosis in the older population of both men and women is unacceptable. There are many different therapies including biphosphonates which can decrease loss of bone and decrease fracture risk in patients who already have had sustained a fracture. Newer therapies such as parathyroid hormone may improve the fracture risk even more than biphosphonates over a shorter period of time.
Simon
Lee S
LS
Harvard Medical School, Beth Isreal Deaconess Hospital, 330 Brookline Avenue, Boston, MA 02215, USA.
D000469:Alkaline Phosphatase / Q000097:blood; D000728:Androgens / Q000627:therapeutic use; D016723:Bone Remodeling / Q000502:physiology; D002116:Calcitonin / Q000627:therapeutic use; D002118:Calcium / Q000652:urine; D003937:Diagnosis, Differential; D004164:Diphosphonates / Q000627:therapeutic use; D004967:Estrogens / Q000627:therapeutic use; D050723:Fractures, Bone / Q000209:etiology / Q000503:physiopathology; D005938:Glucocorticoids / Q000494:pharmacology; D006801:Humans; D009942:Organometallic Compounds / Q000627:therapeutic use; D010010:Osteoclasts / Q000502:physiology; D010024:Osteoporosis / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D010281:Parathyroid Hormone / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000627:therapeutic use; D013876:Thiophenes / Q000627:therapeutic use
D000728:Androgens; D004164:Diphosphonates; D004967:Estrogens; D005938:Glucocorticoids; D009942:Organometallic Compounds; D010281:Parathyroid Hormone; D013876:Thiophenes; C081587:strontium ranelate; D012969:Sodium Fluoride; D002116:Calcitonin; D000469:Alkaline Phosphatase; D002118:Calcium