title: [Low-output radiofrequency ablation combined with transcatheter arterial oily-chemoembolization for hepatocellular carcinoma].
abstract: We devised low-output radiofrequency ablation (RFA)combined with transcatheter arterial chemoembolization using iodized oil mixed with anticancer drugs (TACE) for hepatocellular carcinoma (HCC), to reduce the cooling effect of tumoral arterial blood flow, to prevent intraportal disseminations and intrahepatic metastases by sudden ebullition (bumping), and to obtain an adequate margin of safety. We performed low-output RFA on 10 HCC patients. We performed RFA with a lower output of 90W or less within two weeks after TACE. After the ablation, portal venous-phase CT images showed a low-density margin of 5 mm or larger around the site of iodized-oil accumulation, indicating that the necrotic area completely included the tumor. No intrahepatic metastasis or severe complication occurred. Low-output RFA combined with TACE is a safe, effective therapy for HCC.
authors.affiliation: Department of Radiology, Hidaka General Hospital.
authors.forename: Motoki
authors.initials: M
authors.lastname: Nakai
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Shiraki
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Higashi
authors.forename: Masako
authors.initials: M
authors.lastname: Maeda
authors.forename: Shinya
authors.initials: S
authors.lastname: Sahara
authors.forename: Nozomu
authors.initials: N
authors.lastname: Takeuchi
authors.forename: Masashi
authors.initials: M
authors.lastname: Kimura
authors.forename: Masaki
authors.initials: M
authors.lastname: Terada
authors.forename: Morio
authors.initials: M
authors.lastname: Sato
mesh_terms: D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D006528:Carcinoma, Hepatocellular / Q000601:surgery / Q000628:therapy*; D017115:Catheter Ablation / Q000379:methods*; D016461:Chemoembolization, Therapeutic; D005260:Female; D006801:Humans; D007459:Iodized Oil / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000601:surgery / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin; D007459:Iodized Oil