title: Transient encephalopathy after intrathekal methotrexate chemotherapy: diffusion-weighted MRI.
abstract: Methotrexate (MTX) is an indispensable antimetabolite for the treatment of oncological and immunological disorders in all age groups. Chronic leukoencephalopathy is a well know side effect of MTX, especially in conjunction with intrathecal administration and whole brain radio therapy. However, acute neurotoxicity with confusion, disorientation, seizures and focal deficits has also been reported. Because acute neurological symptoms in patients under chemotherapy for neoplastic disorders may have many reasons, MR-imaging is usually necessary to identify the underlying pathology. Apart from conventional sequences, diffusion-weighted imaging (DW-MRI) is frequently performed. We report on clinical and imaging findings of reversibly restricted diffusion in a patient with transient encephalopathy after intrathecal administration of MTX for recurrent acute lymphatic leukaemia.
authors.affiliation: Department of Neuroradiology, University Hospital Tübingen, Hoppe-Seyler-Street. 3, Tübingen, Germany, D-72076. Wilhehelm.Kucker@orh.nhs.uk
authors.forename: W
authors.initials: W
authors.lastname: Küker
authors.forename: P
authors.initials: P
authors.lastname: Bader
authors.forename: U
authors.initials: U
authors.lastname: Herrlinger
authors.forename: S
authors.initials: S
authors.lastname: Heckl
authors.forename: T
authors.initials: T
authors.lastname: Nägele
mesh_terms: D000293:Adolescent; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis; D002648:Child; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D020258:Neurotoxicity Syndromes / Q000175:diagnosis* / Q000209:etiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000473:pathology; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate