[Features of leucomisin pharmacokinetics in the blood serum upon introduction by various methods].
Pharmacokinetics of the sesquiterpene lactone leucomisin in the blood serum was studied after single intraperitoneal injection and enteral introduction. Analysis of the main pharmacokinetic prameters shows that the drug circulates in the organism for a relatively long time and can be accumulated in the cells, probably, due to the ability of penetrating through the histohematic barriers.
Aksartov
P M
PM
Guliaev
A E
AE
Adekenov
S M
SM
D000284:Administration, Oral; D000818:Animals; D005260:Female; D007274:Injections, Intraperitoneal; D007783:Lactones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D045789:Sesquiterpenes, Guaiane
D007783:Lactones; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; C502417:leucomisin