Lipoxygenase inhibiting ethyl substituted glycoside from Symplocos racemosa.
Phytochemical investigation of Symplocos racemosa resulted in the isolation of a new ethyl substituted glycoside, 1-ethyl brachiose-3'-acetate (1) along with four known compounds ketochaulmoogric acid (2), nonaeicosanol (3), triacontyl palmitate (4) and methyl triacontanoate (5). The substitution of ethyl group on 1 was natural because during the course of extraction and purification ethanol was not used. The structural elucidation of the isolated compounds was based primarily on 1D- and 2D-NMR analysis, including COSY, HMQC, and HMBC correlations. The glycoside 1 and triacontyl palmitate (4) displayed the inhibitory potential against lipoxygenase and urease enzyme, respectively.
Abbasi
Muhammad Athar
MA
HEJ Research Institute of Chemistry, International Center for Chemical Sciences University of Karachi, Karachi 75270, Pakistan. atrabbasi@yahoo.com
Ahmad
Viqar Uddin
VU
Zubair
Muhammad
M
Nawaz
Sarfraz A
SA
Lodhi
Muhammad Arif
MA
Farooq
Umar
U
Choudhary
M Iqbal
MI
D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology; D016859:Lipoxygenase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure
C503477:1-ethyl brachiose-3'-acetate; D006027:Glycosides; D016859:Lipoxygenase Inhibitors