title: GDIs: central regulatory molecules in Rho GTPase activation.
abstract: The GDP dissociation inhibitors (GDIs) are pivotal regulators of Rho GTPase function. GDIs control the access of Rho GTPases to regulatory guanine nucleotide exchange factors and GTPase-activating proteins, to effector targets and to membranes where such effectors reside. We discuss here our current understanding of how Rho GTPase-GDI complexes are regulated by various proteins, lipids and enzymes that exert GDI displacement activity. We propose that phosphorylation mediated by diverse kinases might provide a means of controlling and coordinating Rho GTPase activation.
authors.affiliation: Departments of Immunology and Cell Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Céline
authors.initials: C
authors.lastname: DerMardirossian
authors.forename: Gary M
authors.initials: GM
authors.lastname: Bokoch
mesh_terms: D000818:Animals; D020536:Enzyme Activators / Q000494:pharmacology; D020730:Guanine Nucleotide Dissociation Inhibitors / Q000378:metabolism* / Q000502:physiology*; D020662:Guanine Nucleotide Exchange Factors / Q000494:pharmacology; D006801:Humans; D008055:Lipids / Q000494:pharmacology; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism*; D011506:Proteins / Q000502:physiology; D025521:Tumor Suppressor Proteins; D020691:rab GTP-Binding Proteins / Q000378:metabolism*; D020741:rho GTP-Binding Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D062950:rho Guanine Nucleotide Dissociation Inhibitor gamma; D062947:rho-Specific Guanine Nucleotide Dissociation Inhibitors
chemical_list: C569643:ARHGDIG protein, human; D020536:Enzyme Activators; C086796:GDP dissociation inhibitor 1; D020730:Guanine Nucleotide Dissociation Inhibitors; D020662:Guanine Nucleotide Exchange Factors; D008055:Lipids; D011506:Proteins; D025521:Tumor Suppressor Proteins; D062950:rho Guanine Nucleotide Dissociation Inhibitor gamma; D062947:rho-Specific Guanine Nucleotide Dissociation Inhibitors; D011494:Protein Kinases; D020691:rab GTP-Binding Proteins; D020741:rho GTP-Binding Proteins