Human T-cell leukemia virus type I at age 25: a progress report.
It has been 25 years since the discovery of human T-cell leukemia virus type I (HTLV-I) and its role in adult T-cell leukemia. Here, in brief, we review the current state of our understanding of HTLV-I epidemiology, viral biology, pathogenesis, and treatment. We discuss how HTLV-I may transform cells through destabilization of cellular genomic integrity and induction of cellular tolerance for chromosomal errors.
Matsuoka
Masao
M
Laboratory of Virus Immunology, Institute for Virus Research, Kyoto University, Kyoto, Japan.
Jeang
Kuan-Teh
KT
D002472:Cell Transformation, Viral; D015490:HTLV-I Infections / Q000453:epidemiology / Q000821:virology*; D015368:Human T-lymphotropic virus 1 / Q000502:physiology*; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000821:virology*