A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer.
We examined the coding sequence of 518 protein kinases, approximately 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.
Stephens
Philip
P
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Edkins
Sarah
S
Davies
Helen
H
Greenman
Chris
C
Cox
Charles
C
Hunter
Chris
C
Bignell
Graham
G
Teague
Jon
J
Smith
Raffaella
R
Stevens
Claire
C
O'Meara
Sarah
S
Parker
Adrian
A
Tarpey
Patrick
P
Avis
Tim
T
Barthorpe
Andy
A
Brackenbury
Lisa
L
Buck
Gemma
G
Butler
Adam
A
Clements
Jody
J
Cole
Jennifer
J
Dicks
Ed
E
Edwards
Ken
K
Forbes
Simon
S
Gorton
Matthew
M
Gray
Kristian
K
Halliday
Kelly
K
Harrison
Rachel
R
Hills
Katy
K
Hinton
Jonathon
J
Jones
David
D
Kosmidou
Vivienne
V
Laman
Ross
R
Lugg
Richard
R
Menzies
Andrew
A
Perry
Janet
J
Petty
Robert
R
Raine
Keiran
K
Shepherd
Rebecca
R
Small
Alexandra
A
Solomon
Helen
H
Stephens
Yvonne
Y
Tofts
Calli
C
Varian
Jennifer
J
Webb
Anthony
A
West
Sofie
S
Widaa
Sara
S
Yates
Andrew
A
Brasseur
Francis
F
Cooper
Colin S
CS
Flanagan
Adrienne M
AM
Green
Anthony
A
Knowles
Maggie
M
Leung
Suet Y
SY
Looijenga
Leendert H J
LH
Malkowicz
Bruce
B
Pierotti
Marco A
MA
Teh
Bin
B
Yuen
Siu T
ST
Nicholson
Andrew G
AG
Lakhani
Sunil
S
Easton
Douglas F
DF
Weber
Barbara L
BL
Stratton
Michael R
MR
Futreal
P Andrew
PA
Wooster
Richard
R
D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics*; D018270:Carcinoma, Ductal, Breast / Q000235:genetics*; D004252:DNA Mutational Analysis; D005260:Female; D006801:Humans; D005810:Multigene Family; D009154:Mutation; D011494:Protein Kinases / Q000235:genetics*
D011494:Protein Kinases