title: Successful treatment of Fusarium keratitis with cornea transplantation and topical and systemic voriconazole.
abstract: A case of invasive Fusarium keratitis in a previously healthy male patient was treated successfully with cornea transplantation and systemic and topical voriconazole after treatment failure with topical amphotericin B and systemic itraconazole. Topical voriconazole was well tolerated, and, in conjunction with the oral administration, it resulted in a high level of the drug in the anterior chamber of the eye (which was 160% of the plasma drug level).
authors.affiliation: Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. r.klont@mmb.umcn.nl
authors.forename: Rocus R
authors.initials: RR
authors.lastname: Klont
authors.forename: Cathrien A
authors.initials: CA
authors.lastname: Eggink
authors.forename: Antonius J M M
authors.initials: AJ
authors.lastname: Rijs
authors.forename: Pieter
authors.initials: P
authors.lastname: Wesseling
authors.forename: Paul E
authors.initials: PE
authors.lastname: Verweij
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D003315:Cornea / Q000473:pathology; D016039:Corneal Transplantation; D005670:Fusarium / Q000302:isolation & purification*; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D007634:Keratitis / Q000382:microbiology* / Q000628:therapy*; D008297:Male; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology; D011743:Pyrimidines / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D017964:Itraconazole; D000666:Amphotericin B; D065819:Voriconazole