title: Left ventricular cavity area reflects N-terminal pro-brain natriuretic peptide plasma levels in heart failure.
abstract: OBJECTIVE
  N-terminal pro-brain natriuretic peptide (NT-proBNP) is useful in the diagnosis of heart failure (HF). LV two-dimensional cavity area from end-diastole (LVEDA) and end-systole (LVESA), and LV fractional area change (LVFAC) reflect changes in LV morphology and function without using geometric assumptions. In a multicenter study, we correlated LVEDA, LVESA and LVFAC with NT-proBNP, comparing patients with dilated and ischemic cardiomyopathy.
  
  
  RESULTS
  We studied 106 HF patients. In the dilated group, NT-proBNP correlated with LVEDAI (r=0.6), LVESAI (r=0.7) and LVFAC (r=-0.6), all significant at p<0.001. In patients with ischemic cardiomyopathy we found LVESAI (r=0.3, p<0.05) and LVFAC (r=-0.4, p<0.01). After adjustment for age and BMI, LVFAC and LVESAI were associated in a multiple linear regression analysis with peptide levels (adjusted r(2)=0.5, p<0.001).
  
  
  CONCLUSIONS
  In this study we found a good correlation of NT-proBNP with LV cavity areas and LVFAC. Multiple regression analysis showed that when adjusted for age and BMI, LVFAC and LVESAI are independent predictors of NT-proBNP levels in both dilated and ischemic etiologies. Patients with dilated cardiomyopathy showed better results than those with ischemic cardiomyopathy. We think LV areas are a useful and reproducible parameter, do not need geometric assumptions and reflect NT-proBNP plasma levels.
authors.affiliation: Research Center La Fe Hospital, Valencia, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Taléns-Visconti
authors.forename: Miguel
authors.initials: M
authors.lastname: Rivera Otero
authors.forename: Ma José
authors.initials: MJ
authors.lastname: Sancho-Tello
authors.forename: Fernando García
authors.initials: FG
authors.lastname: de Burgos
authors.forename: Luis
authors.initials: L
authors.lastname: Martínez-Dolz
authors.forename: Begoña
authors.initials: B
authors.lastname: Sevilla
authors.forename: Vicente
authors.initials: V
authors.lastname: Climent
authors.forename: Raquel
authors.initials: R
authors.lastname: Cortés
authors.forename: Antonio
authors.initials: A
authors.lastname: Salvador
authors.forename: Francisco
authors.initials: F
authors.lastname: Sogorb
authors.forename: Vicente
authors.initials: V
authors.lastname: Miro
authors.forename: Ricardo
authors.initials: R
authors.lastname: Valero
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Perez-Boscá
authors.forename: Vicente
authors.initials: V
authors.lastname: Bertomeu
authors.forename: Manuel
authors.initials: M
authors.lastname: Portolés
authors.forename: Rafael
authors.initials: R
authors.lastname: Payá
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002311:Cardiomyopathy, Dilated / Q000097:blood / Q000000981:diagnostic imaging; D015150:Echocardiography, Doppler; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017202:Myocardial Ischemia / Q000097:blood / Q000000981:diagnostic imaging; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011237:Predictive Value of Tests; D012107:Research Design; D013030:Spain / Q000453:epidemiology; D013318:Stroke Volume; D016277:Ventricular Function, Left
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain