Smoking and osteoarthritis: differential effect of nicotine on human chondrocyte glycosaminoglycan and collagen synthesis.
Anecdotal suggestions and retrospective studies indicate an inverse relationship between the incidence of osteoarthritis and individuals who smoke. As a possible explanation, our studies confirm that nicotine upregulates glycosaminoglycan and collagen synthetic activity of articular chondrocytes at physiological levels seen in individuals who smoke.
Gullahorn
L
L
Maricopa Medical Center Orthopaedic Residency Program, Phoenix, AZ 85006, USA.
Lippiello
L
L
Karpman
R
R
D002358:Cartilage, Articular / Q000166:cytology / Q000378:metabolism; D002478:Cells, Cultured; D019902:Chondrocytes / Q000187:drug effects* / Q000378:metabolism; D003094:Collagen / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D006025:Glycosaminoglycans / Q000096:biosynthesis*; D006801:Humans; D009538:Nicotine / Q000494:pharmacology*; D012907:Smoking / Q000378:metabolism
D006025:Glycosaminoglycans; D009538:Nicotine; D003094:Collagen