[Glutamate decarboxylase activity and GABA binding in the brain synaptic membranes in rats with compensatory activation of hypothalamo-pituitary-adrenal system in stress].
The reaction of the rat adrenal cortex and medulla to stress was absent under conditions of compensatory activations of function of hypothalamic-pituitary-adrenal system. At the same time, glutamate decarboxylase activity was increased in the hypothalamus, decreased in the hyppocampus, and remained unchanged in medulla oblongata and cortex of cerebral hemispheres of hemiadrenalectomized rats after stress as compared to rats without stress. On the contrary, the intensity of specific GABA binding by synaptic membranes of medulla oblongata of hemiadrenalectomized rats was increased in response to stress effect it was decreased in the cortex of cerebral hemispheres, and remained unchanged in the hyppocampus.
Myshunina
T M
TM
Kononenko
V Ia
VIa
Levchuk
N I
NI
D000222:Adaptation, Physiological / Q000502:physiology; D000315:Adrenalectomy; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism* / Q000648:ultrastructure; D004195:Disease Models, Animal; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000201:enzymology / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D010913:Pituitary-Adrenal System / Q000201:enzymology / Q000378:metabolism* / Q000503:physiopathology; D011485:Protein Binding; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000201:enzymology / Q000378:metabolism* / Q000503:physiopathology; D013570:Synaptic Membranes / Q000201:enzymology / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D008565:Membrane Proteins; D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase