Current advances in molecular imaging of gene and cell therapy for cancer.
For ensuring success of gene and cell based therapies it is of prime importance to develop technology for non-invasive monitoring of the location and duration of gene expression, distribution and targeting of therapeutically engineered cells and vector particles in vivo. A number of advances have been achieved in high resolution, in vivo imaging methods, such as bioluminescence imaging, Magnetic resonance imaging (MRI), positron emission tomography (PET) and various fluorescence imaging techniques, including fluorescence mediated tomography (FMT) and near infrared fluorescence (NIRF) reflectance imaging. In this review we will discuss different imaging modalities that have found applications in gene and cell therapies of cancer.
Shah
Khalid
K
Center for Molecular Imaging, Massachusetts Gneral Hospital, Boston, MA, USA. kshah@helix.mgh.harvard.edu
D000818:Animals; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D005910:Glioma / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008856:Microscopy, Fluorescence; D015336:Molecular Probe Techniques; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D049268:Positron-Emission Tomography; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon