title: Synthesis and biological activity of new derivatives of 3-phenoxymethyl-4-R-D2-1,2,4-triazoline-5-thione.
abstract: New derivatives of 1,2,4-triazoline-5-thione system were obtained. The effects of both these compounds AP-I (3-phenoxymethyl-4-phenyl-D2-1,2,4-triazoline-5-thione) and AP-II (3-phenoxymethyl-4-ethyl-D2-1,2,4-triazoline-5-thione) on the central nervous system (CNS) of mice were studied.
authors.affiliation: Department of Toxicology, Skubiszewski Medical University of Lublin, 8 Chodźki Str., 20-093 Lublin, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Jagiełło-Wójtowicz
authors.forename: Anna
authors.initials: A
authors.lastname: Chodkowska
authors.forename: Anna
authors.initials: A
authors.lastname: Pachuta-Stec
authors.forename: Maria
authors.initials: M
authors.lastname: Dobosz
mesh_terms: D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D007202:Indicators and Reagents; D008297:Male; D051379:Mice; D010147:Pain Measurement; D011597:Psychomotor Performance / Q000187:drug effects; D012890:Sleep / Q000187:drug effects; D013871:Thiones / Q000138:chemical synthesis* / Q000494:pharmacology*; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: C501450:3-phenoxymethyl-4-R-D2-1,2,4-triazoline-5-thione; D000700:Analgesics; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D002491:Central Nervous System Agents; D007202:Indicators and Reagents; D013871:Thiones; D014230:Triazoles; D006916:5-Hydroxytryptophan