title: Necrobiotic xanthogranuloma associated with lymphoplasmacytic lymphoma. Palliative treatment with carbon dioxide laser.
abstract: Necrobiotic xanthogranuloma (NXG) with paraproteinemia is a rare non-x histiocytosis with conspicuous lesions mainly located on the periorbital skin. A 68-year-old woman, with a previous history of lymphoplasmacytic lymphoma associated with IgG monoclonal gammopathy over a period of almost 4 years, presented typical lesions of NXG on the periorbital regions and left buttock. Treatment with dioxide carbon laser resulted in great improvement of cutaneous lesions, and no evidence of relapse after a 12-month follow-up. The association of NXG with lymphoplasmacytic lymphoma has not been previously described to our knowledge. The treatment of these lesions represents a true challenge for the clinician and palliative treatment of cutaneous lesions of NXG with CO(2) laser may constitute an alternative treatment in selected cases.
authors.affiliation: Department of Dermatology CHU Juan Canalejo Paseo de Sir John Moore s/n 15003 La Coruña, Spain. der@canalejo.org
authors.forename: V
authors.initials: V
authors.lastname: Vieira
authors.forename: J
authors.initials: J
authors.lastname: Del Pozo
authors.forename: W
authors.initials: W
authors.lastname: Martínez
authors.forename: J A
authors.initials: JA
authors.lastname: Veiga-Barreiro
authors.forename: E
authors.initials: E
authors.lastname: Fonseca
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D053685:Laser Therapy; D008223:Lymphoma / Q000473:pathology* / Q000532:radiotherapy; D017441:Necrobiotic Disorders / Q000473:pathology* / Q000532:radiotherapy; D010265:Paraproteinemias / Q000473:pathology* / Q000532:radiotherapy; D018570:Risk Assessment; D016896:Treatment Outcome; D014973:Xanthomatosis / Q000473:pathology* / Q000532:radiotherapy