title: Heteroarylisopropylamines as MAO inhibitors.
abstract: The in vitro monoamine oxidase inhibitory (MAOI) activities of 11 heteroarylisopropylamines vis-à-vis MAO-A and MAO-B were described and interpreted in terms of possible interactions with the enzyme active site. Molecular dynamics simulations allowed a comparison between the most active MAO-A inhibitor of the series, the 1-(2-benzofuryl)-2-aminopropane, and the specific, analogous MAO-A substrate serotonin.
authors.affiliation: Facultad de Química y Biología, Universidad de Santiago, Casilla 40, Correo 33, Santiago, Chile.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Vallejos
authors.forename: Angélica
authors.initials: A
authors.lastname: Fierro
authors.forename: Marcos Caroli
authors.initials: MC
authors.lastname: Rezende
authors.forename: Silvia
authors.initials: S
authors.lastname: Sepúlveda-Boza
authors.forename: Miguel
authors.initials: M
authors.lastname: Reyes-Parada
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008996:Monoamine Oxidase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011437:Propylamines / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared
chemical_list: D008996:Monoamine Oxidase Inhibitors; D011437:Propylamines; C035263:2-propylamine