Atorvastatin-induced severe gastric ulceration: a case report.
A 41-year-old man presented with severe gastric ulceration 3 mo after beginning treatment with atorvastatin 20 mg once daily for hypercholesterolemia. The patient was not taking any ulcerogenic drugs and had no evidence of Helicobacter pylori infection. Proton pump inhibitor therapy was initiated and atorvastatin was replaced by simvastatin with complete resolution of gastrointestinal symptoms. To our knowledge, this is the first report of atorvastatin-induced gastric ulceration, which should be looked for in patients who develop abdominal pain while on this drug.
El-Hajj
Ihab I
II
Department of Internal Medicine, American University of Beirut Medical Center, PO Box, 113-6044, Hamra street, Beirut 110 32090, Lebanon.
Mourad
Fadi H
FH
Shabb
Nina S
NS
Barada
Kassem A
KA
D015746:Abdominal Pain / Q000209:etiology; D000328:Adult; D000924:Anticholesteremic Agents / Q000009:adverse effects*; D000069059:Atorvastatin; D006538:Heptanoic Acids / Q000009:adverse effects*; D006801:Humans; D008297:Male; D011758:Pyrroles / Q000009:adverse effects*; D013276:Stomach Ulcer / Q000139:chemically induced*
D000924:Anticholesteremic Agents; D006538:Heptanoic Acids; D011758:Pyrroles; D000069059:Atorvastatin