title: Effect of electrolytes on the partition coefficient of irbesartan.
abstract: The effect of various electrolytes namely monovalent, divalent and trivalent on the partition coefficient of irbesartan between n-octanol and water systems was investigated at room temperature. It was found that all the electrolytes increase the partition coefficient of irbesartan. The uptake of irbesartan by the organic phase from the aqueous phase is increased with increasing salt concentration except for potassium iodide and aluminum chloride. The effect was found to depend on the size and charge of the ions present in solution.
authors.affiliation: DMI Inc., Wharton, NJ 07885-1600, USA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Mbah
mesh_terms: D000465:Algorithms; D000959:Antihypertensive Agents / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004573:Electrolytes; D006863:Hydrogen-Ion Concentration; D000077405:Irbesartan; D000442:Octanols; D012015:Reference Standards; D012995:Solubility; D013777:Tetrazoles / Q000737:chemistry*
chemical_list: D000959:Antihypertensive Agents; D001713:Biphenyl Compounds; D004573:Electrolytes; D000442:Octanols; D013777:Tetrazoles; D000077405:Irbesartan