title: Medulloblastoma in two successive pregnancies.
abstract: A 24-year old primaparous female at 20 weeks gestation presented acutely with cerebellar symptoms. Magnetic resonance imaging brain showed evidence of a cerebellar vermis lesion. This was diagnosed as medulloblastoma on histopathological analysis. She underwent surgical debulking and radiotherapy. Interestingly, the lesion recurred 4 years later on her second pregnancy. She underwent further surgical debulking and adjuvant chemotherapy. We believe this is the first reported description of recurrent medulloblastoma in successive pregnancies. A brief discussion on this disease and its management in pregnancy setting is also presented.
authors.affiliation: Department of Medical Oncology, Beamont Hospital, Dublin, Ireland. albiruni_ryan@yahoo.co.uk
authors.forename: Albiruni Ryan Abdul
authors.initials: AR
authors.lastname: Razak
authors.forename: Qasiem
authors.initials: Q
authors.lastname: Nasser
authors.forename: Patrick
authors.initials: P
authors.lastname: Morris
authors.forename: David
authors.initials: D
authors.lastname: Alcutt
authors.forename: Liam
authors.initials: L
authors.lastname: Grogan
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002528:Cerebellar Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005047:Etoposide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000627:therapeutic use; D008527:Medulloblastoma / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis* / Q000628:therapy; D016896:Treatment Outcome; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D003520:Cyclophosphamide; D007069:Ifosfamide