Transient overexpression of the 5-HT1A receptor impairs water-maze but not hole-board performance.
Previously, we showed that mice that overexpress the 5-HT(1A) receptor transiently from embryonic to perinatal stages show reduced anxiety and changes in brain serotonin turnover as adults. Here, we investigated the long-term effects of the temporary overexpression of the 5-HT(1A) receptor during early embryonic and perinatal development on the performance in two memory tasks. In the hole-board test mice that were homozygous for the transgene showed similar behavioral habituation but increased locomotion compared to heterozygous mice. In contrast water-maze performance of homozygous mice was impaired compared to heterozygous mice. These results suggest that a transient overexpression of 5-HT(1A) receptor during embryonic and perinatal development has detrimental effects on water-maze performance at adult stages.
Bert
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B
Institute of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universität Berlin, Koserstr. 20, 14195 Berlin, Germany.
Dere
E
E
Wilhelmi
N
N
Kusserow
H
H
Theuring
F
F
Huston
J P
JP
Fink
H
H
D000704:Analysis of Variance; D000818:Animals; D005106:Exploratory Behavior / Q000502:physiology*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006185:Habituation, Psychophysiologic / Q000502:physiology*; D006624:Hippocampus / Q000254:growth & development / Q000378:metabolism; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics / Q000502:physiology*; D012737:Sex Factors
D044282:Receptor, Serotonin, 5-HT1A