title: Mean platelet volume as marker of restenosis after percutaneous transluminal coronary angioplasty in patients with stable and unstable angina pectoris.
abstract: BACKGROUND
  Several experimental and clinical studies have demonstrated that platelet size and function correlate since large platelets are hemostatically more reactive than platelets of normal size. Since platelets play a crucial role in vascular remodeling after percutaneous transluminal coronary angioplasty (PTCA), we investigated the influence of the mean platelet volume (MPV), a parameter of platelet size, on restenosis after PTCA.
  
  
  METHODS
  The retrospective study comprised 174 patients who underwent elective PTCA and follow-up angiography within 6 months thereafter. According to the follow-up angiograms, the patients were assigned to group A ("restenosis", n=74) or group B ("no restenosis", n=100). Both groups were compared in regard to pre-procedural hematological routine parameters including MPV, platelet count, hematocrit, white blood cell count and fibrinogen.
  
  
  RESULTS
  MPV was significantly increased in group A, compared with that in group B (8.75+/-0.99 fl vs. 8.04+/-0.74 fl, p<0.001). This difference in MPV was evident in patients with stable and unstable angina pectoris. In addition, MPV had an impact on the time-related incidence of angiographic restenosis, as early restenosis was associated with higher pre-procedural MPV values. Platelet count correlated inversely with MPV (r=-0.36, p<0.01) and was significantly lower in group A than in group B. The remaining hematological parameters were not different in both groups.
  
  
  CONCLUSIONS
  The MPV seems to be a marker of coronary restenosis in patients undergoing PTCA. Patients with high pre-procedural MPV values might benefit from an intensified antiplatelet therapy after coronary interventions.
authors.affiliation: Department of Medicine-Cardiology, University of Bonn, Bonn, Germany. Alexander.Yang@web.de
authors.forename: Alexander
authors.initials: A
authors.lastname: Yang
authors.forename: Luciano
authors.initials: L
authors.lastname: Pizzulli
authors.forename: Berndt
authors.initials: B
authors.lastname: Lüderitz
mesh_terms: D000787:Angina Pectoris / Q000097:blood* / Q000150:complications / Q000601:surgery*; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D001792:Blood Platelets / Q000473:pathology*; D048429:Cell Size; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications / Q000601:surgery*; D023903:Coronary Restenosis / Q000097:blood* / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D012189:Retrospective Studies