title: Intermittent hypoxia modulates Na+ channel expression in developing mouse brain.
abstract: Because our previous work showed that intermittent hypoxia alters neuronal excitability and Na+ current density, we examined in this work the effect of intermittent hypoxia on Na+ channel subtypes using 3H-saxitoxin (3H-STX) autoradiography and immunoblotting. Mice were exposed to intermittent hypoxia for 2 or 4 weeks from postnatal day 2 or 3. A 2-week intermittent hypoxia reduced cerebral STX binding density with significant decrease in Na(v)1.2 in the rostral and Na(v)1.1 in the caudal regions. In contrast, a 4-week intermittent hypoxia tended to increase STX binding density in most brain regions. Our data suggest that intermittent hypoxia differentially regulates plasma membrane Na+ channels in the developing brain, depending on duration of intermittent hypoxia.
authors.affiliation: Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, LMP 3107, New Haven, CT 06520, USA.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhao
authors.forename: Jin
authors.initials: J
authors.lastname: Xue
authors.forename: Xiang-Qun
authors.initials: XQ
authors.lastname: Gu
authors.forename: Gabriel G
authors.initials: GG
authors.lastname: Haddad
authors.forename: Ying
authors.initials: Y
authors.lastname: Xia
mesh_terms: D000222:Adaptation, Physiological; D000375:Aging / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000254:growth & development* / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D002534:Hypoxia, Brain / Q000378:metabolism*; D051379:Mice; D015222:Sodium Channels / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D015222:Sodium Channels