title: Membranoproliferative glomerulonephritis type II in a 10-year-old girl.
abstract: The clinical course of a 10-year-old female patient who presented with hematuria, proteinuria, and hypertension is described. Four months after being diagnosed with acute glomerulonephritis, the child was referred to a pediatric nephrologist due to persistent hematuria and unresolved proteinuria. A renal biopsy was performed due to the persistent urinary abnormalities and a family history of renal failure. The renal biopsy demonstrated pathological findings characteristic of membranoproliferative glomerulonephritis type II. The child was treated with an antihypertensive agent and steroids. Despite poor prognostic clinical and pathological features, she has minimal urinary abnormalities, normal renal function, and normal blood pressure on antihypertensive medication six years after the diagnosis of membranoproliferative glomerulonephritis type II.
authors.affiliation: Indiana University Hospital, Pathology/Microbiology, Indianapolis, IN 46202, USA. metibbs@iupui.edu
authors.forename: Martha E
authors.initials: ME
authors.lastname: Tibbs
authors.forename: Sharon P
authors.initials: SP
authors.lastname: Andreoli
authors.forename: Carrie L
authors.initials: CL
authors.lastname: Phillips
mesh_terms: D002648:Child; D019963:Clinical Chemistry Tests; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D004656:Enalapril / Q000627:therapeutic use; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D005922:Glomerulonephritis, IGA / Q000175:diagnosis; D015432:Glomerulonephritis, Membranoproliferative / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D015433:Glomerulonephritis, Membranous / Q000175:diagnosis; D006403:Hematologic Tests; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology; D007674:Kidney Diseases / Q000175:diagnosis / Q000235:genetics; D007678:Kidney Glomerulus / Q000648:ultrastructure; D008775:Methylprednisolone / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D004656:Enalapril; D011241:Prednisone; D008775:Methylprednisolone