title: [Protective effect of estrogens replacement on apoptosis cells of nasal mocosas in ovariectomized rats].
abstract: OBJECTIVE
  To study the protective effect of nylestriol on apoptosis cells of atrophic nasal mucosas in ovariectomized rats and the difference between nasal drip and gastrogavage.
  
  
  METHODS
  Sixty rats with atrophic rhinitis were divided into four groups at random (each with 15 rats): contrary group (Cg), ovariectomized group (Og), ovariectomized + nylestriol nasal drip group (ONNDg), and ovariectomized + nylestriol by gastrogavage (ONGg). Earlier apoptosis cells of nasal mucosas taken from nasal septum were measured with flow cytometry.
  
  
  RESULTS
  After being ovariectomized, the number of apoptosis cells of mucosas increased. In ONGg, the number of apoptosis cells of mucosas increased at 15 d after operation (P < 0.05), but it recovered at 30 d and 60 d after operation. In ONGg, the number of apoptosis cells of mucosas increased at 15 d and 30 d after operation (P < 0.05), but it recovered at 60 d after operation.
  
  
  CONCLUSIONS
  Estrogen replacement by gastrogavage and via nasal drip have effects on protecting cells of mucosas from lacking of estrogen by decreasing apoptosis cells in ovariectomized rats. It might cost more time to get therapeutic effectiveness via nasal drip than by gastrogavage.
authors.affiliation: Department of Otolaryngology, the First People's Hospital of Yunnan Province, Kunming, 650001, China. qibenming@21cn.com
authors.forename: Benming
authors.initials: B
authors.lastname: Qi
authors.forename: Li
authors.initials: L
authors.lastname: Fan
authors.forename: Hequn
authors.initials: H
authors.lastname: Jiang
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Xiupei
authors.initials: X
authors.lastname: He
authors.forename: Tao
authors.initials: T
authors.lastname: Wan
authors.forename: Chunchun
authors.initials: C
authors.lastname: Cai
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Deng
authors.forename: Xinghua
authors.initials: X
authors.lastname: Tian
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D004847:Epithelial Cells / Q000187:drug effects* / Q000473:pathology; D015914:Estrogen Replacement Therapy; D005260:Female; D009297:Nasal Mucosa / Q000187:drug effects* / Q000473:pathology; D010052:Ovariectomy; D011800:Quinestrol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: C010722:nylestriol; D011800:Quinestrol