[Effects of 2450 MHz microwave on long-term potentiation of hippocampus and lipofuscin contents in rat brain].
OBJECTIVE
To study the mechanism of the effects of microwave on learning and memory.


METHODS
Long-term potentiation (LTP) of hippocampus induced potential and lipofuscin content in rat brain were studied. After irradiated by a 2450 MHz microwave, rats hippocampus induced potential in vivo was recorded and lipofuscin content in the brain was measured by fluorospectrophotometry.


RESULTS
Continuous microwave with 10-25 mW/cm2 intensity could inhibit the amplitude of the population spike (PS) of weak and strong stimuli induced LTP with an intensity-effect relationship. At 25 mW/cm2, lipofuscin content was significantly higher than control and 10 mW/cm2 group (P<0.05).


CONCLUSIONS
Continuous microwave with 10-25 mW/cm2 intensity impairs learning and memory by restraining hippocampus LTP and brain lipofuscin content.
Zhao
Ya-li
YL
Institute of Space Medico-Engineering, Beijing, China.
Peng
Xiao-dong
XD
Yang
Yu-hua
YH
Ma
Hong-bo
HB
Song
Jin-ping
JP
Pu
Jing-sui
JS
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D006624:Hippocampus / Q000502:physiology* / Q000528:radiation effects*; D007858:Learning / Q000528:radiation effects; D008062:Lipofuscin / Q000378:metabolism / Q000528:radiation effects*; D017774:Long-Term Potentiation / Q000502:physiology / Q000528:radiation effects*; D008568:Memory / Q000528:radiation effects; D008872:Microwaves; D051381:Rats; D017208:Rats, Wistar
D008062:Lipofuscin