title: Anticancer activity of some isothiazolo[5,4-b]pyridine derivatives.
abstract: Two small series of derivatives of isothiazolopyridine with the tertiary amine base center bridged through a methylene or 2-hydroxypropylene chain were tested in vitro for anticancer activity. The results of the preliminary studies showed that the compounds, especially those with a 2-hydroxypropylene spacer, exhibited a broad spectrum of anticancer action observed at a concentration of approximately 20 mM/L at the GI50 level.
authors.affiliation: Department of Chemistry of Drugs, Wrocław Medical University, 1 Tamka Str., 50-137 Wrocław.
authors.forename: Piotr
authors.initials: P
authors.lastname: Swiatek
authors.forename: Wiesław
authors.initials: W
authors.lastname: Malinka
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D011725:Pyridines; D013844:Thiazoles