title: Effect of preoperative concurrent chemoradiotherapy in locally advanced low rectal cancer after radical resection surgery.
abstract: To evaluate the outcome of patients with locally advanced low rectal adenocarcinoma who required preoperative concurrent chemoradiotherapy (CCRT), a total of 22 patients underwent preoperative CCRT and radical resection for locally advanced low rectal adenocarcinoma. Patients received concurrent chemotherapy with high-dose 5-fluorouracil (5-FU) in continuous infusion and leucovorin and preoperative radiation with a mean dose of 50.4 Gy (range, 45-50.4 Gy). Radical resection surgery was performed 6 weeks after treatment. Fifty-five percent of patients achieved tumor downstaging, and 14% patients. showed pathological complete remission. No severe hematological and gastrointestinal toxicity of preoperative CCRT was noted. Sphincter-saving rate was 82%, and there were no deaths related to preoperative CCRT and surgery. Overall, 3-year survival rate was 69%, and a rate of locoregional recurrence was 13.6%. This study shows that many patients with locally advanced rectal cancer can be operated on with sphincter-saving radical resection surgery under good local control after preoperative concurrent chemoradiotherapy, which induces tumor downstaging.
authors.affiliation: Department of Colorectal Surgery, Changhua Christian Hospital, Changhua, Taiwan.
authors.forename: Chung-Wah
authors.initials: CW
authors.lastname: Lam
authors.forename: William Tzu-Liang
authors.initials: WT
authors.lastname: Chen
authors.forename: Mu-Tai
authors.initials: MT
authors.lastname: Liu
authors.forename: Cheng-Shyong
authors.initials: CS
authors.lastname: Chang
authors.forename: Teng-Min
authors.initials: TM
authors.lastname: Huang
authors.forename: Ger-Hau
authors.initials: GH
authors.lastname: Hsu
authors.forename: Hong-Chang
authors.initials: HC
authors.lastname: Chen
authors.forename: Koung-Hong
authors.initials: KH
authors.lastname: Hsiao
authors.forename: Chien-Min
authors.initials: CM
authors.lastname: Chiu
authors.forename: Jau-Jie
authors.initials: JJ
authors.lastname: You
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D006801:Humans; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D016019:Survival Analysis