Oxidative reactivity of Cu-TESHHK- and its alanine analogues.
Redox properties of Cu(II) complexes of the terminally blocked hexapeptide -TESHHK- and a series of its alanine substituted analogs: -TASHHK-, -TEAHHK-, -TESAHK-, -TESHAK-, were investigated in their reactions with hydrogen peroxide in solution and by cyclic voltammetry in a broad range of pH. The formation of reactive oxygen species was followed with the use of spectrophotometric indicators, NDMA and NBT. The results indicate that the ability of these complexes to generate hydroxyl-like radicals correlates with the formation of active Cu(III) complexes resulting from the oxidation of Cu(II) by H2O2, which interact with further H2O2 molecules specifically.
Kaczmarek
Piotr
P
Faculty of Chemistry, University of Wrocław, 50-383 Wrocław, Poland.
Jezowska-Bojczuk
Malgorzata
M
Gatner
Kazimierz
K
Bal
Wojciech
W
D000409:Alanine / Q000031:analogs & derivatives*; D003300:Copper / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D006861:Hydrogen Peroxide / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D009842:Oligopeptides / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species
D009842:Oligopeptides; D009942:Organometallic Compounds; D017382:Reactive Oxygen Species; D003300:Copper; D006861:Hydrogen Peroxide; D000409:Alanine