Low-dose aspirin does not improve ovarian stimulation, endometrial response, or pregnancy rates for in vitro fertilization.
BACKGROUND
The purpose of this study is to determine if low-dose aspirin improved ovarian stimulation, endometrial response, or IVF pregnancy rates in our program.


METHODS
Retrospective analysis of 316 consecutive IVF cycles from 1995 through 2001. Aspirin 80 mg daily was initiated at the start of luteal leuprolide in 72 cycles. The 244 controls received no aspirin during treatment.


RESULTS
The live birth rate in aspirin users was 29%, slightly lower compared to 41% in the no aspirin control group (p = 0.07). Implantation rates were 21% with aspirin and 30% in the control population (p = 0.01). There was no difference in the maximal endometrial thickness between aspirin and non-aspirin groups. The two groups were similar regarding age, gonadotropin ampules, embryos, number of embryos transferred, prior parity, diagnosis, use of intracytoplasmic sperm injection, and stimulation protocol.


CONCLUSIONS
Low-dose aspirin was not beneficial to IVF patients in our program. Aspirin does not enhance endometrial thickness, augment the ovarian response, or improve pregnancy rates.
Hurst
Bradley S
BS
Department of Obstetrics and Gynecology, Carolinas Medical Center, 1000 Blythe Blvd, Charlotte, NC 28203, USA. bhurst@carolinas.org
Bhojwani
Jennifer T
JT
Marshburn
Paul B
PB
Papadakis
Margaret A
MA
Loeb
Terry A
TA
Matthews
Michelle L
ML