title: Lipoxygenase inhibiting ethyl substituted glycoside from Symplocos racemosa.
abstract: Phytochemical investigation of Symplocos racemosa resulted in the isolation of a new ethyl substituted glycoside, 1-ethyl brachiose-3'-acetate (1) along with four known compounds ketochaulmoogric acid (2), nonaeicosanol (3), triacontyl palmitate (4) and methyl triacontanoate (5). The substitution of ethyl group on 1 was natural because during the course of extraction and purification ethanol was not used. The structural elucidation of the isolated compounds was based primarily on 1D- and 2D-NMR analysis, including COSY, HMQC, and HMBC correlations. The glycoside 1 and triacontyl palmitate (4) displayed the inhibitory potential against lipoxygenase and urease enzyme, respectively.
authors.affiliation: HEJ Research Institute of Chemistry, International Center for Chemical Sciences University of Karachi, Karachi 75270, Pakistan. atrabbasi@yahoo.com
authors.forename: Muhammad Athar
authors.initials: MA
authors.lastname: Abbasi
authors.forename: Viqar Uddin
authors.initials: VU
authors.lastname: Ahmad
authors.forename: Muhammad
authors.initials: M
authors.lastname: Zubair
authors.forename: Sarfraz A
authors.initials: SA
authors.lastname: Nawaz
authors.forename: Muhammad Arif
authors.initials: MA
authors.lastname: Lodhi
authors.forename: Umar
authors.initials: U
authors.lastname: Farooq
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology; D016859:Lipoxygenase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: C503477:1-ethyl brachiose-3'-acetate; D006027:Glycosides; D016859:Lipoxygenase Inhibitors