title: An unusual quinolinone alkaloid from Waltheria douradinha.
abstract: The chemical investigation of the methanolic extract of the root bark of Waltheria douradinha (Sterculiaceae) afforded an unusual quinolinone alkaloid named waltherione-A (1). Its structure was determined mainly by NMR spectroscopic methods. The antibacterial activity of waltherione-A (1) and the corresponding O-methylated derivative (2) was tested against three gram-negative and three gram-positive bacteria, with only (2) having moderate activity.
authors.affiliation: Departamento de Química (NPPN), Universidade Federal de Santa Maria, CEP: 97105-900 Santa Maria, RS, Brazil.
authors.forename: Solange C S M
authors.initials: SC
authors.lastname: Hoelzel
authors.forename: Eleno R
authors.initials: ER
authors.lastname: Vieira
authors.forename: Sandro R
authors.initials: SR
authors.lastname: Giacomelli
authors.forename: Ionara I
authors.initials: II
authors.lastname: Dalcol
authors.forename: Nilo
authors.initials: N
authors.lastname: Zanatta
authors.forename: Ademir F
authors.initials: AF
authors.lastname: Morel
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D019660:Malvaceae / Q000737:chemistry*; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D011804:Quinolines / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; C502882:O-methylwaltherione A; D011804:Quinolines; C502881:waltherione-A