title: Antioxidant activity of DHC-1, an herbal formulation, in experimentally-induced cardiac and renal damage.
abstract: DHC-1, an herbal formulation derived from the popular plants Bacopa monniera, Emblica officinalis, Glycyrrhiza glabra, Mangifera indica and Syzygium aromaticum was studied for its antioxidant activity. The protective effect of DHC-1 in isoproterenol-induced myocardial infarction and cisplatin-induced renal damage were studied. A significant reduction in the serum markers of heart and kidney damage and the extent of lipid peroxidation with a concomitant increase in the enzymatic (SOD and CAT) and non-enzymatic antioxidants (reduced glutathione) were observed in DHC-1 pretreated animals compared with the isoproterenol or cisplatin alone treated animals. Thus it can be concluded that DHC-1 possesses a protective effect against both damaged heart and kidneys in rats. This beneficial effect may be attributed, at least in part, to its antioxidant activity.
authors.affiliation: Pharmacy Department, Faculty of Technology and Engineering, The M.S. University of Baroda, Baroda -390 001, Gujarat, India.
authors.forename: P A
authors.initials: PA
authors.lastname: Bafna
authors.forename: R
authors.initials: R
authors.lastname: Balaraman
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D034681:Bacopa; D002945:Cisplatin; D005260:Female; D006035:Glycyrrhiza; D007545:Isoproterenol; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D031022:Mangifera; D009203:Myocardial Infarction / Q000139:chemically induced / Q000517:prevention & control*; D029842:Phyllanthus emblica; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal; D020011:Protective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D027842:Syzygium
chemical_list: D000975:Antioxidants; C496347:DHC-1, herbal formulation; D010936:Plant Extracts; D020011:Protective Agents; D007545:Isoproterenol; D002945:Cisplatin