Advancing chemistry and biology through diversity-oriented synthesis of natural product-like libraries.
Natural products provide the inspiration for a variety of strategies used in the diversity-oriented synthesis of novel small-molecule libraries. These libraries can be based on core scaffolds from individual natural products, specific substructures found across a class of natural products, or general structural characteristics of natural products. An increasing body of evidence supports the effectiveness of these strategies for identifying new biologically active molecules. Moreover, these efforts have led to significant advances in synthetic organic chemistry. Larger-scale evaluation of these approaches is on the horizon, using screening data that will be made publicly available in the new PubChem database.
Shang
Shiying
S
Pharmacology Program, Weill Graduate School of Medical Sciences of Cornell University, Ithaca, New York, USA.
Tan
Derek S
DS
D001685:Biological Factors / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D030562:Databases, Protein; D015195:Drug Design; D015394:Molecular Structure; D011487:Protein Conformation
D001685:Biological Factors