Fluoroquinolone-resistant Streptococcus agalactiae: epidemiology and mechanism of resistance.
Quinolone-resistant Streptococcus agalactiae bacteria were recovered from single-patient isolates and found to contain mutations in the gyrase and topoisomerase IV genes. Pulsed-field gel electrophoresis demonstrated that four isolates from the same long-term care facility were closely related; in seven cases, quinolone-resistant Haemophilus influenzae and S. agalactiae bacteria were isolated from the same patient.
Wehbeh
Wehbeh
W
Infectious Disease Section, Department of Medicine and Lang Research Center, New York Hospital Queens, 56-45 Main Street, Flushing, NY 11355, USA. WEW9004@nyp.org
Rojas-Diaz
Roberto
R
Li
Xinying
X
Mariano
Noriel
N
Grenner
Louise
L
Segal-Maurer
Sorana
S
Tommasulo
Barbara
B
Drlica
Karl
K
Urban
Carl
C
Rahal
James J
JJ
D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000494:pharmacology*; D027081:DNA Gyrase / Q000235:genetics; D027101:DNA Topoisomerase IV / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D024841:Fluoroquinolones / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009154:Mutation; D013290:Streptococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D013292:Streptococcus agalactiae / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D027101:DNA Topoisomerase IV; D027081:DNA Gyrase