title: Mu opiate active substances trefentanil and naloxonazine: tritiation at high specific activity.
abstract: Methods are presented to synthesize and characterize [propyl-(3)H] trefentanil 3 and [propenyl-(3)H] naloxonazine 6.
authors.affiliation: PerkinElmer Life and Analytical Sciences, Inc., 549 Albany St., Boston, MA 02118, USA.
authors.forename: David G
authors.initials: DG
authors.lastname: Ahern
authors.forename: Judith A
authors.initials: JA
authors.lastname: Egan
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Seguin
authors.forename: Crist N
authors.initials: CN
authors.lastname: Filer
mesh_terms: D007553:Isotope Labeling / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009270:Naloxone / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry; D010880:Piperidines / Q000032:analysis / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000032:analysis / Q000138:chemical synthesis; D017450:Receptors, Opioid, mu / Q000032:analysis* / Q000737:chemistry*; D013777:Tetrazoles / Q000032:analysis / Q000737:chemistry*; D014316:Tritium / Q000032:analysis / Q000737:chemistry*
chemical_list: D010880:Piperidines; D019275:Radiopharmaceuticals; D017450:Receptors, Opioid, mu; D013777:Tetrazoles; D014316:Tritium; D009270:Naloxone; C080498:trefentanil; C034643:naloxonazine