Benzothieno[3,2-b]indole derivatives as potent selective estrogen receptor modulators.
A series of estrogen receptor ligands based on benzothieno[3,2-b]indole were synthesized and their binding affinity for estrogen receptor subtypes (ERalpha and ERbeta) and effects on mouse uterus and bone were evaluated. Some of these compounds showed strong binding affinity to ER and significantly increased the bone mineral density of ovariectomized mice.
Ji
Qinggang
Q
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences.
Gao
Jie
J
Wang
Junbo
J
Yang
Chunhao
C
Hui
Xin
X
Yan
Xueming
X
Wu
Xihan
X
Xie
Yuyuan
Y
Wang
Ming-Wei
MW
D000818:Animals; D005260:Female; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D051379:Mice; D020845:Selective Estrogen Receptor Modulators / Q000737:chemistry / Q000494:pharmacology*
D007211:Indoles; D020845:Selective Estrogen Receptor Modulators