title: Immune competence and switched memory B cells in common variable immunodeficiency.
abstract: Common variable immunodeficiency (CVID) is presumed to be a heterogenous group of disorders with potentially separate etiologies. Memory B cell subsets, characterized by CD27 expression, have been suggested as a means to subclassify CVID patients. 53 patients were subdivided based on percentages of switched memory B cells (CD27+IgM-IgD-): 33 were placed in Group I (<0.4% CD27+IgM-IgD- cells/peripheral lymphocytes) and 20 in Group II (>0.4%). The median serum IgG for subjects in Group I was lower at 145 mg/dl vs. 329.5 mg/dl for Group II (P=0.038). Post-pneumococcal vaccine IgG response was tested; the median protective response was 0.5 serotypes for Group I and 3 serotypes for Group II (P=0.041). Autoimmune and granulomatous disease was found in higher rates in Group I. CVID patients with decreased percentages of switched memory B cells have lower levels of serum IgG, less effective pneumococcal vaccine antibody responses, and higher rates of autoimmune and granulomatous disease.
authors.affiliation: Division of Clinical Immunology, Department of Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1089, New York, NY 10029, USA. jimmy.ko@mssm.edu
authors.forename: Jimmy
authors.initials: J
authors.lastname: Ko
authors.forename: Lin
authors.initials: L
authors.lastname: Radigan
authors.forename: Charlotte
authors.initials: C
authors.lastname: Cunningham-Rundles
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001327:Autoimmune Diseases / Q000453:epidemiology; D001402:B-Lymphocytes / Q000276:immunology*; D001424:Bacterial Infections / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D017074:Common Variable Immunodeficiency / Q000097:blood / Q000276:immunology*; D005260:Female; D006099:Granuloma / Q000453:epidemiology; D006801:Humans; D007107:Immune System / Q000187:drug effects / Q000276:immunology; D017578:Immunoglobulin Class Switching / Q000276:immunology; D007136:Immunoglobulins / Q000097:blood / Q000276:immunology; D007156:Immunologic Memory / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D022242:Pneumococcal Vaccines / Q000276:immunology / Q000494:pharmacology; D015995:Prevalence
chemical_list: D007136:Immunoglobulins; D022242:Pneumococcal Vaccines