title: Steryl epoxide, secobutanolide and butanolides from the stem wood of Machilus zuihoensis.
abstract: A steryl epoxide, machillene (1), a secobutanolide, secomahubanolide (2), and two butanolides, zuihoenalide (3), and 3-(1-methoxyoctadecyl)-5-methylene-5H-furan-2-one (4), together with 12 known compounds, were isolated from stem wood of Machilus zuihoensis. Their structures were determined by means of spectroscopic analyses. Machillene (1) showed cytotoxic activity against NUGC-3 and HONE-1 cancer cell lines in vitro.
authors.affiliation: Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Republic of China.
authors.forename: Ming-Jen
authors.initials: MJ
authors.lastname: Cheng
authors.forename: Ian-Lih
authors.initials: IL
authors.lastname: Tsai
authors.forename: Shoiw-Ju
authors.initials: SJ
authors.lastname: Lee
authors.forename: Bolleddula
authors.initials: B
authors.lastname: Jayaprakasam
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology; D002073:Butanes / Q000737:chemistry; D045744:Cell Line, Tumor; D004852:Epoxy Compounds / Q000737:chemistry*; D005663:Furans / Q000737:chemistry*; D006801:Humans; D019770:Lauraceae / Q000737:chemistry*; D015394:Molecular Structure; D014934:Wood
chemical_list: C502886:3-(1-methoxyoctadecyl)-5-methylene-5H-furan-2-one; D000972:Antineoplastic Agents, Phytogenic; D002073:Butanes; D004852:Epoxy Compounds; D005663:Furans