title: [Vitamin D and bone quality].
abstract: Active vitamin D analogs such as alfacalcidol have been shown to reduce fracture risk in clinical trials in spite of its moderate effects on bone mass. It has been reported that active vitamin D analogs may improve bone quality, by amelioration of bone microarchitecture, by specific effect on cortical bones, by acceleration of calcification, and by effect on nature of bone matrix proteins. The bone quality assessments that clarify the effect on bone mechanical properties will become important for the positioning of osteoporosis drugs.
authors.affiliation: Product Research Department, Chugai Pharmaceutical Co., Ltd.
authors.forename: Ayako
authors.initials: A
authors.lastname: Shiraishi
authors.forename: Naoki
authors.initials: N
authors.lastname: Kubota
authors.forename: Noboru
authors.initials: N
authors.lastname: Kubodera
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000187:drug effects*; D006801:Humans; D014807:Vitamin D / Q000494:pharmacology*
chemical_list: D014807:Vitamin D