title: N,N'-Bis(3-aminopropyl)-2,7-diamino-1,8-naphthyridine stabilized a single pyrimidine bulge in duplex DNA.
abstract: We here show the first identified ligand 2,7-diamino-1,8-naphthyridine (DANP) that strongly and specifically binds to the single cytosine and thymine bulges with exclusively 1:1 stoichiometry.
authors.affiliation: Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Kyoto 615-8510, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Suda
authors.forename: Akio
authors.initials: A
authors.lastname: Kobori
authors.forename: Jinhua
authors.initials: J
authors.lastname: Zhang
authors.forename: Gosuke
authors.initials: G
authors.lastname: Hayashi
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakatani
mesh_terms: D004247:DNA / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009287:Naphthyridines / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D009287:Naphthyridines; D011743:Pyrimidines; D004247:DNA; C030986:pyrimidine