title: Lung volumes in infants who had mild to moderate bronchopulmonary dysplasia.
abstract: "New" bronchopulmonary dysplasia (BPD) has been suggested to be a maldevelopment sequence with reduced alveolarisation of the lungs; affected infants then would be predicted to have low lung volumes. The aim of this study was to test that hypothesis by comparing the lung volumes of infants who had had mild-moderate BPD with those without BPD of similar postmenstrual age. Lung volumes of 17 infants who had mild-moderate BPD (oxygen dependent beyond 28 days, but not past term) (BPD infants) were compared to those of 17 infants without BPD (non-BPD infants). All were born at less than 33 weeks of gestation and studied at postmenstrual ages of 33 to 39 weeks. Lung volume was assessed by measurement of functional residual capacity (FRC). The BPD infants had lower lung volumes (median 19.1 ml/kg) than the non-BPD infants (median 26.5 ml/kg) (p = 0.0001). The BPD compared to the non-BPD infants were of greater postnatal age (p = 0.0003), born at a lower gestational age (p = 0.0001) and of lighter birthweight (p = 0.0001). Regression analysis, however, demonstrated that lung volume was significantly related to BPD status (p = 0.005), independently of postnatal age, birthweight and gestational age. It is concluded that the lower lung volumes of the infants who had had mild-moderate BPD support the hypothesis that new BPD is associated with poor alveolarisation.
authors.affiliation: Division of Asthma, Allergy and Lung Biology, Guy's, King's and St Thomas' School of Medicine, King's College London, London, UK. anne.greenough@kcl.ac.uk
authors.forename: Anne
authors.initials: A
authors.lastname: Greenough
authors.forename: Gabriel
authors.initials: G
authors.lastname: Dimitriou
authors.forename: Ravindra Y
authors.initials: RY
authors.lastname: Bhat
authors.forename: Simon
authors.initials: S
authors.lastname: Broughton
authors.forename: Simon
authors.initials: S
authors.lastname: Hannam
authors.forename: Gerrard F
authors.initials: GF
authors.lastname: Rafferty
authors.forename: Jaana A
authors.initials: JA
authors.lastname: Leipälä
mesh_terms: D001724:Birth Weight; D001997:Bronchopulmonary Dysplasia / Q000503:physiopathology*; D016022:Case-Control Studies; D005260:Female; D005652:Functional Residual Capacity; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000503:physiopathology*; D008176:Lung Volume Measurements; D008297:Male; D011446:Prospective Studies; D012044:Regression Analysis; D012720:Severity of Illness Index