title: [Fibrin-depolymerization activity and the antiplatelet effect of small cyclic and linear proline-containing peptides].
abstract: In our study of the effect of proline-containing linear di- and tri-peptides (Pro-Gly, Pro-Gly-Pro) and cyclic peptide cPro-Gly in vitro, we have found that they show depolymerizing activity towards the nonstabilized form of fibrin in the presence and in the absence of sigma-aminocapronic acid, an inhibitor of enzymatic fibrinolysis. The peptides have an inhibitory effect on platelet aggregation in platelet-enriched blood plasma, when the process is induced by ADP, they also diminish the activity of factor XIIIa in blood plasma.
authors.forename: V E
authors.initials: VE
authors.lastname: Pastorova
authors.forename: L A
authors.initials: LA
authors.lastname: Liapina
authors.forename: I P
authors.initials: IP
authors.lastname: Alshmarin
authors.forename: P U
authors.initials: PU
authors.lastname: Ostrovskaia
authors.forename: T A
authors.initials: TA
authors.lastname: Gudasheva
authors.forename: E V
authors.initials: EV
authors.lastname: Lugovskoĭ
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D004151:Dipeptides / Q000494:pharmacology*; D005337:Fibrin / Q000187:drug effects; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology*; D010456:Peptides, Cyclic / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011392:Proline / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051381:Rats
chemical_list: D004151:Dipeptides; D005343:Fibrinolytic Agents; D009842:Oligopeptides; D010456:Peptides, Cyclic; D010975:Platelet Aggregation Inhibitors; C113164:prolyl-glycyl-proline; C057749:prolylglycine; D005337:Fibrin; D011392:Proline