title: Systemic B-cell chronic lymphocytic leukemia first presenting as a cutaneous infiltrate arising at the site of a herpes simplex scar.
abstract: Cutaneous infection by Herpes virus (simplex or zoster) is a common non-specific skin manifestation in patients affected by B-cell chronic lymphocytic leukemia (B-CLL) or other malignant lymphomas and is attributed to the patients' immunodeficiency. Persistent or shortly recurrent lesions, however, may represent specific cutaneous infiltrates of systemic B-CLL of several months' duration. The occurrence of these lesions as first manifestation of B-CLL is rare and previously reported only on herpes zoster scars. A case of a 63-year-old male patient with cutaneous B-CLL infiltrate of the right oral commissure at the site of herpes simplex scar as first sign of the disease is herein reported.
authors.affiliation: Department of Surgery, Thraki Medical Center, Alexandroupolis, Greece.
authors.forename: D
authors.initials: D
authors.lastname: Kakagia
authors.forename: D
authors.initials: D
authors.lastname: Tamiolakis
authors.forename: M
authors.initials: M
authors.lastname: Lambropoulou
authors.forename: A
authors.initials: A
authors.lastname: Kakagia
authors.forename: A
authors.initials: A
authors.lastname: Grekou
authors.forename: N
authors.initials: N
authors.lastname: Papadopoulos
mesh_terms: D018951:Antigens, CD20 / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D018956:CD5 Antigens / Q000032:analysis; D002921:Cicatrix / Q000150:complications / Q000473:pathology*; D006560:Herpes Labialis / Q000150:complications*; D006801:Humans; D016130:Immunophenotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D017254:Leukemic Infiltration / Q000473:pathology*; D051917:Leukosialin / Q000032:analysis; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology*
chemical_list: D018951:Antigens, CD20; D000951:Antigens, Neoplasm; D018956:CD5 Antigens; D051917:Leukosialin