title: [Oral controlled-release oxycodone for the treatment of chronic pain. Data from 4196 patients].
abstract: Oral controlled-release oxycodone has been available for the treatment of chronic pain in Germany since 1998. Controlled trials have shown good clinical efficacy and tolerability. This survey reports results from six open prospective multicenter trials. In these trials 4196 patients suffering from cancer pain and non-cancer-related pain with inadequate pain relief were treated with oral controlled-release oxycodone for 3-4 weeks. Only a few participating physicians were pain specialists. A total of 356 patients suffering from pain of the musculoskeletal system and receiving oxycodone therapy were monitored for 6 months. Exclusion from the studies was due mainly to inadequate analgesia, side effects, and noncompliance. The efficacy of oxycodone was rated to be better than moderate by most of the patients, quality of life parameters increased significantly, and patient satisfaction was high. The treatment with oral controlled-release oxycodone was a safe and effective option even when used by nonspecialized physicians.
authors.affiliation: Klinik für Anästhesiologie und operative Intensivmedizin, Klinikum der Universität zu Köln. jan.gaertner@medizin.uni-koeln.de
authors.forename: J
authors.initials: J
authors.lastname: Gaertner
authors.forename: M
authors.initials: M
authors.lastname: Frank
authors.forename: B
authors.initials: B
authors.lastname: Bosse
authors.forename: R
authors.initials: R
authors.lastname: Sabatowski
authors.forename: F
authors.initials: F
authors.lastname: Elsner
authors.forename: T
authors.initials: T
authors.lastname: Giesecke
authors.forename: L
authors.initials: L
authors.lastname: Radbruch
mesh_terms: D000284:Administration, Oral; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use*; D002908:Chronic Disease; D003692:Delayed-Action Preparations; D006801:Humans; D009140:Musculoskeletal Diseases / Q000503:physiopathology; D010098:Oxycodone / Q000008:administration & dosage / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy*; D012189:Retrospective Studies
chemical_list: D000701:Analgesics, Opioid; D003692:Delayed-Action Preparations; D010098:Oxycodone