title: Action of a novel pyrrolo[1,2-c][1.3]benzodiazepine on the viability of Jurkat and neuronal/glial cells.
abstract: We have designed and synthesized several structural isomers of anthramycin (heterocycles 2, 3, 5, 6, and 8) and found that, in particular, pyrrolobenzodiazepine 8 induces DNA cleavage and formation of small fragments of DNA. The cytotoxic effects of 8 were manifested with both non-transformed primary neuronal/glial cells and transformed Jurkat cells. The other compounds did not change the viability either of transformed or of non-transformed cells, and induced DNA cleavage to a lesser extent.
authors.affiliation: Department of Chemistry, University of Ioannina, GR-451 10 Ioannina, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Rotas
authors.forename: Ketevan
authors.initials: K
authors.lastname: Natchkebia
authors.forename: Nino
authors.initials: N
authors.lastname: Natsvlishvili
authors.forename: Merab
authors.initials: M
authors.lastname: Kekelidze
authors.forename: Athanasios
authors.initials: A
authors.lastname: Kimbaris
authors.forename: George
authors.initials: G
authors.lastname: Varvounis
authors.forename: David
authors.initials: D
authors.lastname: Mikeladze
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001569:Benzodiazepines / Q000138:chemical synthesis / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004247:DNA / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D019169:Jurkat Cells; D015458:Leukemia, T-Cell / Q000188:drug therapy* / Q000473:pathology; D009457:Neuroglia / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001569:Benzodiazepines; D004247:DNA