Biological evaluation of Tyr6 and Ser7 modified drosocin analogues.
An array of analogues of the cationic antimicrobial peptide drosocin was synthesized containing substitutions of Tyr6 and Ser7 in order to increase the proteolytic stability. Stabilizing the N-terminus with unnatural amino acids increased the serum stability of analogues by almost a factor 30 over an 8 h period.
de Visser
Peter C
PC
TNO Defense, Security and Safety, AA Rijswijk, The Netherlands.
van Hooft
Peter A V
PA
de Vries
Anne-Marij
AM
de Jong
Ad
A
van der Marel
Gijsbert A
GA
Overkleeft
Herman S
HS
Noort
Daan
D
D000595:Amino Acid Sequence; D006020:Glycopeptides / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D012694:Serine / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014443:Tyrosine / Q000737:chemistry*
D006020:Glycopeptides; C082117:drosocin; D014443:Tyrosine; D012694:Serine