title: Cyclophosphamide improves the function of post-infarct hearts by reducing old infarct area and accelerating the mobilization of CD34+ cells.
abstract: BACKGROUND
  Myelosuppressives such as cyclophosphamide (Cy) and 5-fluorouracil (5FU), which can increase circulating CD34+ cells, may have a beneficial effect in the post-infarct heart.
  
  
  RESULTS
  Twenty-four hours after 30-min ischemia-reperfusion, rabbits were intravenously treated with Cy (20 mg/kg), 5FU (15 mg/kg) or saline (S). Cy significantly improved cardiac function and remodeling and decreased the old infarct area 1 month after infarction, compared with those given S. The number of circulating CD34+ cells was higher and neovascularization and matrix metalloproteinase-1 was induced in the Cy group.
  
  
  CONCLUSIONS
  Cy has potential for post-infarct treatment.
authors.affiliation: Department of Cardiology, Regeneration Medicine and Bioethics, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Misao
authors.forename: Masazumi
authors.initials: M
authors.lastname: Arai
authors.forename: Takamasa
authors.initials: T
authors.lastname: Ohno
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ushikoshi
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Takahashi
authors.forename: Genzou
authors.initials: G
authors.lastname: Takemura
authors.forename: Shinya
authors.initials: S
authors.lastname: Minatoguchi
authors.forename: Takako
authors.initials: T
authors.lastname: Fujiwara
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Fujiwara
mesh_terms: D000818:Animals; D018952:Antigens, CD34 / Q000097:blood*; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage*; D003520:Cyclophosphamide / Q000008:administration & dosage*; D015428:Myocardial Reperfusion Injury / Q000097:blood / Q000188:drug therapy*; D011817:Rabbits; D020127:Recovery of Function / Q000187:drug effects*
chemical_list: D018952:Antigens, CD34; D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide