A fabrication platform for electrically mediated optically active biofunctionalized sites in BioMEMS.
We report a new approach for microfluidic optical bioanalysis that is based on the electrically driven assembly of bio-components on a transparent sidewall and the optical detection of the assembled components using planar waveguides. This allows localized electrical signals for bio-assembly and optical signals for bio-detection that can easily be applied in MEMS systems. We demonstrate a BioMEMS design incorporating this scheme and its output signal when using fluorescent detection.
Powers
Michael A
MA
Department of Electrical and Computer Engineering, College Park, MD 20742, USA.
Koev
Stephan T
ST
Schleunitz
Arne
A
Yi
Hyunmin
H
Hodzic
Vildana
V
Bentley
William E
WE
Payne
Gregory F
GF
Rubloff
Gary W
GW
Ghodssi
Reza
R
D032701:Biomimetics / Q000295:instrumentation* / Q000379:methods; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D044085:Microfluidics / Q000295:instrumentation* / Q000379:methods; D008856:Microscopy, Fluorescence / Q000295:instrumentation* / Q000379:methods; D055095:Optics and Photonics; D012680:Sensitivity and Specificity