[Impaired endothelium-dependent vasodilation and arterial elasticity in patients with coronary artery disease].
OBJECTIVE
To investigate the change in endothelium-dependent vasodilation and arterial elasticity and the association between them in patients with coronary artery disease (CAD).


METHODS
Thirty patients with CAD and thirty control subjects were recruited for this study. Flow-mediated dilation (FMD) in the brachial artery was evaluated by ultrasound Doppler flow method. They also underwent a non-invasive assessment of C(1) large artery and C(2) small artery indices by using pulse wave analysis.


RESULTS
FMD was significantly reduced in CAD group compared with that in control group [(5.17 +/- 2.13)% vs (11.1 +/- 4.36)%, P < 0.05], C(1) large artery elasticity index was similar between the two groups [(11.59 +/- 4.56) ml/mm Hg x 10 vs (12.11 +/- 3.82) ml/mm Hg x 10, P > 0.05]. However, C(2) small artery elasticity index was significantly reduced in CAD group compared with that in control group [(4.20 +/- 1.80) ml/mm Hg x 100 vs (6.26 +/- 2.36) ml/mm Hg x 100, P < 0.05]. There was a positive association between reduced C(2) small artery elasticity index and impaired FMD (r = 0.53, P < 0.05).


CONCLUSIONS
There were impaired endothelium-dependent vasodilation and reduced C(2) small artery elasticity index in the patients with CAD, which were closely correlated with each other. The present study suggested that the measurement of C(2) small artery elasticity might be used as a novel index for the determination of endothelial function.
Tao
Jun
J
Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. taojungz@yahoo.com
Tu
Chang
C
Wang
Yan
Y
Yang
Zhen
Z
Liu
Dong-Hong
DH
Xu
Ming-Guo
MG
Wang
Hao-Mei
HM
Zhang
Yan
Y
Zeng
Qun-Ying
QY
Chen
Guo-Wei
GW
D000368:Aged; D001158:Arteries / Q000503:physiopathology*; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000503:physiopathology*; D004548:Elasticity; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014664:Vasodilation / Q000502:physiology