title: Distribution of cysteinyl leukotriene receptor 2 in human traumatic brain injury and brain tumors.
abstract: OBJECTIVE
  To determine the distribution of cysteinyl leukotriene receptor 2 (CysLT2), one of the cysteinyl leukotriene receptors, in human brains with traumatic injury and tumors.
  
  
  METHODS
  Brain specimens were obtained from patients who underwent brain surgery. CysLT2 in brain tissues was examined using immunohistochemical analysis.
  
  
  RESULTS
  CysLT2 was expressed in the smooth muscle cells (not in the endothelial cells) of arteries and veins. CysLT2 was also expressed in the granulocytes in both vessels and in the brain parenchyma. In addition, CysLT2 was detected in neuron- and glial-appearing cells in either the late stages of traumatic injury or in the area surrounding the tumors. Microvessels regenerated 8 d after trauma and CysLT2 expression was recorded in their endothelial cells.
  
  
  CONCLUSIONS
  CysLT2 is distributed in vascular smooth muscle cells and granulocytes, and brain trauma and tumor can induce its expression in vascular endothelial cells and in a number of other cells.
authors.affiliation: Department of Neurosurgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Hu
authors.forename: Gao
authors.initials: G
authors.lastname: Chen
authors.forename: Jian-min
authors.initials: JM
authors.lastname: Zhang
authors.forename: Wei-ping
authors.initials: WP
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Qiu-fu
authors.initials: QF
authors.lastname: Ge
authors.forename: Hong-tian
authors.initials: HT
authors.lastname: Yao
authors.forename: Wei
authors.initials: W
authors.lastname: Ding
authors.forename: Zhong
authors.initials: Z
authors.lastname: Chen
authors.forename: Er-qing
authors.initials: EQ
authors.lastname: Wei
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001254:Astrocytoma / Q000378:metabolism / Q000473:pathology; D001921:Brain / Q000098:blood supply / Q000378:metabolism; D001930:Brain Injuries / Q000378:metabolism* / Q000473:pathology; D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology; D042783:Endothelial Cells / Q000378:metabolism*; D005260:Female; D018303:Ganglioglioma / Q000378:metabolism / Q000473:pathology; D006098:Granulocytes / Q000378:metabolism; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D008833:Microcirculation / Q000473:pathology; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D032389:Myocytes, Smooth Muscle / Q000378:metabolism*; D018077:Receptors, Leukotriene / Q000378:metabolism*
chemical_list: D008565:Membrane Proteins; D018077:Receptors, Leukotriene; C412375:cysteinyl leukotriene receptor 2