title: HA/TCP compounding of a porous CaP biomaterial improves bone formation and scaffold degradation--a long-term histological study.
abstract: In the present study, two biphasic calcium phosphate biomaterials (BCP) with HA/TCP ratios of 50/50 and 30/70 were obtained from a pure HA biomaterial. The biomaterials which showed the same three-dimensional geometry were implanted into corticocancellous costal defects of sheep. In the specimens of all three biomaterials, abundant bone formation, mineral dissolution from the biomaterial scaffolds, and active cellular resorption of the scaffolds was present after 6 and 12 months. Backscattered electron microscopy showed bone invasion into the pores of the scaffolds and micromechanical interlocking at the bone/biomaterial interface without intervening soft tissue. The pattern of bone formation and scaffold resorption was different for cortical and cancellous bone. No time-based effect, however, was observed. Overall, the BCP biomaterials had formed significantly more bone than the HA biomaterial. Also, scaffold resorption, which was followed by a replacement with newly formed bone, was significantly higher in the BCP biomaterials. Although no significant differences were observed between both BCP biomaterials, the present study had confirmed the assumption that HA/TCP compounding was suitable to improve bone formation and scaffold resorption in the investigated biomaterials and at the same time maintain the osteoconductive properties of the scaffolds.
authors.affiliation: Department of Cranio-Maxillofacial and Oral Surgery, Medical University of Vienna, Austria. christian.schopper@meduniwien.ac.at
authors.forename: Christian
authors.initials: C
authors.lastname: Schopper
authors.forename: Farzad
authors.initials: F
authors.lastname: Ziya-Ghazvini
authors.forename: Walter
authors.initials: W
authors.lastname: Goriwoda
authors.forename: Doris
authors.initials: D
authors.lastname: Moser
authors.forename: Felix
authors.initials: F
authors.lastname: Wanschitz
authors.forename: Else
authors.initials: E
authors.lastname: Spassova
authors.forename: Georgios
authors.initials: G
authors.lastname: Lagogiannis
authors.forename: Alexandra
authors.initials: A
authors.lastname: Auterith
authors.forename: Rolf
authors.initials: R
authors.lastname: Ewers
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001861:Bone Regeneration; D018786:Bone Substitutes; D001842:Bone and Bones / Q000378:metabolism; D002130:Calcium Phosphates / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D005260:Female; D008422:Materials Testing; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D010012:Osteogenesis; D012272:Ribs / Q000473:pathology; D012542:Scattering, Radiation; D012756:Sheep; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; D017886:Durapatite; C020243:calcium phosphate; C018392:tricalcium phosphate