title: Transient overexpression of the 5-HT1A receptor impairs water-maze but not hole-board performance.
abstract: Previously, we showed that mice that overexpress the 5-HT(1A) receptor transiently from embryonic to perinatal stages show reduced anxiety and changes in brain serotonin turnover as adults. Here, we investigated the long-term effects of the temporary overexpression of the 5-HT(1A) receptor during early embryonic and perinatal development on the performance in two memory tasks. In the hole-board test mice that were homozygous for the transgene showed similar behavioral habituation but increased locomotion compared to heterozygous mice. In contrast water-maze performance of homozygous mice was impaired compared to heterozygous mice. These results suggest that a transient overexpression of 5-HT(1A) receptor during embryonic and perinatal development has detrimental effects on water-maze performance at adult stages.
authors.affiliation: Institute of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universität Berlin, Koserstr. 20, 14195 Berlin, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Bert
authors.forename: E
authors.initials: E
authors.lastname: Dere
authors.forename: N
authors.initials: N
authors.lastname: Wilhelmi
authors.forename: H
authors.initials: H
authors.lastname: Kusserow
authors.forename: F
authors.initials: F
authors.lastname: Theuring
authors.forename: J P
authors.initials: JP
authors.lastname: Huston
authors.forename: H
authors.initials: H
authors.lastname: Fink
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D005106:Exploratory Behavior / Q000502:physiology*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006185:Habituation, Psychophysiologic / Q000502:physiology*; D006624:Hippocampus / Q000254:growth & development / Q000378:metabolism; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics / Q000502:physiology*; D012737:Sex Factors
chemical_list: D044282:Receptor, Serotonin, 5-HT1A