[Synergistic antioxidative effect of vitamins E and C on low density lipoproteins from smokers and non-smokers subjects].
LDL-lipids peroxidation is an important step in LDL atherogenicity. Tobacco smoke, promotes oxidative stress and reduces LDL-alfa tocoferol content and plasmatic vitamin C concentration. The objective of this double-blind randomized study was to assess the effect of vitamins E and C combined administration, on oxidative susceptibility of LDL isolated from 20 smokers and 10 non-smokers healthy volunteers who received placebo for 15 days and then concomitantly received 400 mg/d vitamin E and 1000 mg/d vitamin C for 30 days. At the end of placebo administration of and vitamins E and C combination; plasma total cholesterol, LDL-C and HDL-C values did not change significantly (p>0.05), plasma triglycerides increased significantly within a normal accepted range (p<0.05) and LDL oxidation susceptibility in smokers decreased by 41,3% and in non-smokers by 54,4% (p<0.05 vs placebo). In conclusion, simultaneous administration of vitamins E and C exerts an important antioxidant effect on LDL-lipids peroxidation. This effect could operate as an attenuating factor of the increased atherogenesis commonly observed in smoker subjects.
Barón
Luz
L
Escuela de Medicina JMVargas, Cátedra de Bioquimica, Laboratorio de Lipoproteinas, Universidad Central de Venezuela (UCV), Caracas, Venezuela.
Romero-Vecchione
Eduardo
E
López
Flor
F
Apitz
Rafael
R
D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage* / Q000494:pharmacology; D001205:Ascorbic Acid / Q000008:administration & dosage* / Q000494:pharmacology; D016022:Case-Control Studies; D004311:Double-Blind Method; D004357:Drug Synergism; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008077:Lipoproteins, LDL / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000097:blood*; D024502:alpha-Tocopherol / Q000008:administration & dosage* / Q000494:pharmacology
D000975:Antioxidants; D008055:Lipids; D008077:Lipoproteins, LDL; D024502:alpha-Tocopherol; D001205:Ascorbic Acid