Chromosome segregation: Aurora B gets Tousled.
Aurora B kinases play important roles during mitosis in eukaryotic cells; new work in Caenorhabditis elegans has identified the Tousled kinase TLK-1 as a substrate activator of the model nematode's Aurora B kinase AIR-2 which acts to ensure proper chromosome segregation during cell division.
Richie
Christopher T
CT
Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
Golden
Andy
A
D000818:Animals; D064107:Aurora Kinase B; D017173:Caenorhabditis elegans / Q000235:genetics / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D020090:Chromosome Segregation / Q000235:genetics*; D004789:Enzyme Activation / Q000502:physiology; D006657:Histones / Q000378:metabolism; D008938:Mitosis / Q000502:physiology*; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*
D029742:Caenorhabditis elegans Proteins; D006657:Histones; C498928:TLK-1 protein, C elegans; D064107:Aurora Kinase B; D017346:Protein Serine-Threonine Kinases; C491506:air-2 protein, C elegans