Glycine transporters: crucial roles of pharmacological interest revealed by gene deletion.
The functions of the high-affinity glycine transporters (GLYTs) in vivo have been revealed recently using gene-deletion studies. Results from studies of homozygous knockout mice have reinforced the idea that GLYTs might be specific clinical targets to modulate inhibitory glycine-mediated neurotransmission. In addition, molecular and behavioural analysis of heterozygous mice has confirmed the therapeutic potential of GLYT1 inhibitors in the treatment of several neurological and psychiatric disorders.
Aragón
Carmen
C
Centro de Biología Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autónoma de Madrid, Consejo Superior de Investigaciones Científicas, 28049 Madrid, Spain. caragon@cbm.uam.es
López-Corcuera
Beatriz
B
D026921:Amino Acid Transport Systems, Neutral / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000378:metabolism; D050487:Glycine Plasma Membrane Transport Proteins; D006801:Humans; D051379:Mice; D018345:Mice, Knockout
D026921:Amino Acid Transport Systems, Neutral; D050487:Glycine Plasma Membrane Transport Proteins; C493268:SLC6A9 protein, human; C493267:Slc6a9 protein, mouse