title: [The metabolic syndrome: effects of a pronounced weight loss induced by bariatric surgery].
abstract: The prevalence of obesity is rising worldwide dramatically, affecting up to 50 percent of the population. The epidemic of obesity leads to a marked increase in the metabolic syndrome, a cluster of cardiovascular risk factors characterized by visceral obesity, insulin resistance, low HDL-Cholesterol, hypertriglyceridemia, and a subclinical proinflammatory state. In the last years, the NCEP and the WHO highlighted and defined the key features of the metabolic syndrome to facilitate the clinical diagnosis and preventive interventions. The conservative therapy of obesity and the metabolic syndrome by life style intervention and pharmacological interventions leads only to moderate weight loss with inconstant long-term success. Intervention by bariatric surgery can serve as a model for the metabolic effects of permanent weight loss. In several studies the pronounced weight loss induced a reduction of almost all components of the metabolic syndrome, including glucose and lipid status and is followed by an improvement in the quality of life. Recent research suggested a decrease in mortality rate in addition to cost effectiveness of bariatric surgery.
authors.affiliation: Klinische Abteilung für Allgemeine Innere Medizin, Universitätsklinik für Innere Medizin, Medizinische Universität Innsbruck, Innsbruck, Osterreich.
authors.forename: Julia
authors.initials: J
authors.lastname: Engl
authors.forename: Ursula
authors.initials: U
authors.lastname: Hanusch-Enserer
authors.forename: Rudolf
authors.initials: R
authors.lastname: Prager
authors.forename: Josef R
authors.initials: JR
authors.lastname: Patsch
authors.forename: Christoph
authors.initials: C
authors.lastname: Ebenbichler
mesh_terms: D049088:Bariatrics; D015904:Biliopancreatic Diversion; D015992:Body Mass Index; D002986:Clinical Trials as Topic; D003362:Cost-Benefit Analysis; D004730:Endothelium, Vascular / Q000503:physiopathology; D005260:Female; D005544:Forecasting; D015390:Gastric Bypass; D015391:Gastroplasty; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D008019:Life Style; D015187:Lipectomy; D008279:Magnetic Resonance Imaging; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000191:economics / Q000453:epidemiology / Q000378:metabolism / Q000401:mortality / Q000517:prevention & control; D009765:Obesity / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000378:metabolism / Q000601:surgery*; D015995:Prevalence; D011788:Quality of Life; D012307:Risk Factors; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D015431:Weight Loss; D014944:World Health Organization
chemical_list: D005947:Glucose