title: Highly prevalent putative quadruplex sequence motifs in human DNA.
abstract: We report here the results of a systematic search for the existence and prevalence of potential intramolecular G-quadruplex forming sequences in the human genome. We have also examined the tendency for particular sequences of 'loop' regions to occur in particular positions with respect to the G-tracts in a quadruplex. Using arithmetic ratio and probability techniques we have discovered frequent and systematic occurrence of certain sequence types, the most prominent being a potential quadruplex containing CCTGT in the first 'loop' position. Being able to highlight types of potential quadruplex sequences in G-rich regions is an important step in searching for biologically relevant sequences and finding their function.
authors.affiliation: CRUK Biomolecular Structure Group, The School of Pharmacy, University of London 29-39 Brunswick Square, London WC1N 1AX, UK.
authors.forename: Alan K
authors.initials: AK
authors.lastname: Todd
authors.forename: Matthew
authors.initials: M
authors.lastname: Johnston
authors.forename: Stephen
authors.initials: S
authors.lastname: Neidle
mesh_terms: D001483:Base Sequence; D019295:Computational Biology; D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D015894:Genome, Human; D006147:Guanine / Q000032:analysis*; D006801:Humans; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D017422:Sequence Analysis, DNA
chemical_list: D006147:Guanine; D004247:DNA