title: Total synthesis of the potent antitumor polyketide (-)-callystatin A.
abstract: A highly convergent and efficient total synthesis of the potent antitumor polyketide (-)-callystatin A is described. The synthesis required 19 steps from N-propionyl oxazolidinone 23 and produced the desired product in 3.5% overall yield.
authors.affiliation: Instituto de Química, Universidade Estadual de Campinas, UNICAMP, C. P. 6154, CEP 13084-971, Campinas, SP, Brazil. ldias@iqm.unicamp.br
authors.forename: Luiz C
authors.initials: LC
authors.lastname: Dias
authors.forename: Paulo R R
authors.initials: PR
authors.lastname: Meira
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D020650:Combinatorial Chemistry Techniques; D005231:Fatty Acids, Unsaturated / Q000138:chemical synthesis*; D018942:Macrolides / Q000138:chemical synthesis*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D005231:Fatty Acids, Unsaturated; D018942:Macrolides; C421091:callystatin A