Soluble CD30 and HLA antibodies as potential risk factors for kidney transplant rejection.
Recent literary data suggest that high pre- and post-transplant serum levels of the soluble CD30 (sCD30) molecule may be a risk factor for acute rejection and worse prognosis of the transplanted kidney. The aim of our study was to correlate the concentrations of sCD30 and the presence of HLA antibodies as defined by flow cytometry and ELISA with the clinical course and graft prognosis after transplantation. One hundred and seventeen kidney transplant patients were included into the study. The incidence of rejection episodes, graft function and graft survival for up to 1 year post-transplant were evaluated. Soluble CD30 levels before transplantation were virtually the same in patients who experienced rejection and in non-rejecting patients. In both patient groups, a significant decrease of sCD30 was detected 2 weeks after transplantation (104.4 U/ml before vs. 37.0 U/ml post-transplant, P < 0.001). However, there was a substantial difference in the level of decrease of sCD30 between rejecting and non-rejecting patients. Patients without rejection had lower sCD30 values (31.2 U/ml post-transplant) compared to patients who experienced rejection episodes (62.9 U/ml), P < 0.04. Multifactorial analysis showed that antibodies to HLA class II antigens and elevated concentrations of sCD30 shortly after transplantation were associated with increased risk for acute rejection in the first post-transplant year. Measurement of soluble CD30 after transplantation, taken into consideration with the presence of HLA class II antibodies, might be helpful for evaluating the potential risk for acute rejection.
Slavcev
Antonij
A
Department of Immunogenetics, Institute for Clinical and Experimental Medicine (IKEM), Videnska 1958/9, Prague 140 21, Czech Republic. tosl@medicon.cz
Lácha
Jiri
J
Honsová
Eva
E
Sajdlová
Helena
H
Lodererová
Alena
A
Vitko
Stefan
S
Skibová
Jelena
J
Striz
Ilja
I
D000328:Adult; D000906:Antibodies / Q000097:blood* / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D005260:Female; D006084:Graft Rejection / Q000097:blood* / Q000276:immunology; D006680:HLA Antigens / Q000097:blood / Q000276:immunology*; D006801:Humans; D017730:Ki-1 Antigen / Q000097:blood / Q000276:immunology*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors
D000906:Antibodies; D015415:Biomarkers; D006680:HLA Antigens; D017730:Ki-1 Antigen