title: Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication.
abstract: BACKGROUND
  Little is known about the general population prevalence or severity of DSM-IV mental disorders.
  
  
  OBJECTIVE
  To estimate 12-month prevalence, severity, and comorbidity of DSM-IV anxiety, mood, impulse control, and substance disorders in the recently completed US National Comorbidity Survey Replication.
  
  
  METHODS
  Nationally representative face-to-face household survey conducted between February 2001 and April 2003 using a fully structured diagnostic interview, the World Health Organization World Mental Health Survey Initiative version of the Composite International Diagnostic Interview.
  
  
  METHODS
  Nine thousand two hundred eighty-two English-speaking respondents 18 years and older.
  
  
  METHODS
  Twelve-month DSM-IV disorders.
  
  
  RESULTS
  Twelve-month prevalence estimates were anxiety, 18.1%; mood, 9.5%; impulse control, 8.9%; substance, 3.8%; and any disorder, 26.2%. Of 12-month cases, 22.3% were classified as serious; 37.3%, moderate; and 40.4%, mild. Fifty-five percent carried only a single diagnosis; 22%, 2 diagnoses; and 23%, 3 or more diagnoses. Latent class analysis detected 7 multivariate disorder classes, including 3 highly comorbid classes representing 7% of the population.
  
  
  CONCLUSIONS
  Although mental disorders are widespread, serious cases are concentrated among a relatively small proportion of cases with high comorbidity.
authors.affiliation: Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA. ncs@hcp.med.harvard.edu
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Kessler
authors.forename: Wai Tat
authors.initials: WT
authors.lastname: Chiu
authors.forename: Olga
authors.initials: O
authors.lastname: Demler
authors.forename: Kathleen R
authors.initials: KR
authors.lastname: Merikangas
authors.forename: Ellen E
authors.initials: EE
authors.lastname: Walters
mesh_terms: D000293:Adolescent; D000328:Adult; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000453:epidemiology*; D008875:Middle Aged; D019964:Mood Disorders / Q000175:diagnosis / Q000453:epidemiology; D010698:Phobic Disorders / Q000175:diagnosis / Q000453:epidemiology; D015995:Prevalence; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D012720:Severity of Illness Index; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000453:epidemiology; D014481:United States / Q000453:epidemiology