Disordered RNA chaperone proteins: from functions to disease.
RNA chaperones are ubiquitous proteins that play pivotal roles in cellular RNA metabolism and RNA virus replication. Here we propose that they act by organizing complex and highly dynamic networks of RNA-RNA, RNA-protein and protein-protein interactions. How this is achieved and how their malfunction may lead to disease will be discussed through the examples of human immunodeficiency virus type 1 nucleocapsid protein (NCp7), the fragile X mental retardation protein and the prion protein.
Ivanyi-Nagy
R
R
Unité de Virologie Humaine (412), Ecole Normale Supérieure de Lyon et Institut National de la Santé et de la Recherche Médicale, IFR 128, 46 allée d'Italie, 69 364 Lyon, France.
Davidovic
L
L
Khandjian
E W
EW
Darlix
J-L
JL
D000818:Animals; D036022:Capsid Proteins / Q000378:metabolism; D051860:Fragile X Messenger Ribonucleoprotein 1; D005600:Fragile X Syndrome / Q000378:metabolism; D015683:Gene Products, gag / Q000378:metabolism; D015658:HIV Infections / Q000378:metabolism; D015497:HIV-1; D006801:Humans; D008607:Intellectual Disability / Q000378:metabolism; D018832:Molecular Chaperones / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D017096:Prion Diseases / Q000378:metabolism; D011328:Prions / Q000378:metabolism; D011487:Protein Conformation; D012313:RNA / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism; D013329:Structure-Activity Relationship; D014764:Viral Proteins / Q000378:metabolism; D054301:gag Gene Products, Human Immunodeficiency Virus
D036022:Capsid Proteins; D051860:Fragile X Messenger Ribonucleoprotein 1; D015683:Gene Products, gag; D018832:Molecular Chaperones; D009419:Nerve Tissue Proteins; D011328:Prions; D012313:RNA; D016601:RNA-Binding Proteins; D014764:Viral Proteins; D054301:gag Gene Products, Human Immunodeficiency Virus; C497683:FMR1 protein, human; C071884:NCP7 protein, Human immunodeficiency virus 1