Tissue migration by parasitic helminths - an immunoevasive strategy?
Migration through host tissues has major costs for parasitic helminths in terms of energy expenditure, risks of attrition and the need to adapt to varying physicochemical environments. Nevertheless, such migratory phases seem to confer a specific survival advantage. One reason for this might be the avoidance of specific host immune-defence mechanisms designed to protect against threats at mucosal surfaces.
Mulcahy
Grace
G
Department of Veterinary Microbiology and Parasitology, Faculty of Veterinary Medicine and Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland. grace.mulcahy@ucd.ie
O'Neill
Sandra
S
Fanning
June
J
McCarthy
Elaine
E
Sekiya
Mary
M
D000222:Adaptation, Physiological; D000818:Animals; D006373:Helminthiasis / Q000276:immunology* / Q000469:parasitology*; D006376:Helminths / Q000276:immunology / Q000502:physiology*; D006790:Host-Parasite Interactions; D006801:Humans; D007113:Immunity, Innate; D018928:Immunity, Mucosal; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology