title: Four years experience in bladder preserving management for muscle invasive bladder cancer.
abstract: OBJECTIVE
  To evaluate the bladder preservation strategy in invasive bladder cancer particularly relapse, progression and complications.
  
  
  METHODS
  From January 2000 to May 2004 a total of 24 patients (mean age of 81 years; range 68-92) with muscle invasive bladder cancer who had refused or were not eligible for cystectomy were followed up for a period of up to four years.
  
  
  RESULTS
  24 (21 M/3 F) patients were followed up for a mean time of 680 (182-1253) days. All patients complained of frequency, urgency and severe nocturia. The second most frequent complication was bleeding which required a salvage cystectomy in 7 cases. Other major complications were intestinal occlusion in three cases, an enterovesical fistula, brain metastasis requiring neurosurgical intervention and radiation therapy of the brain, bone metastasis in the cervical spinal column and chronic renal failure. The mean re-admission rate was 8 per patient and the mean time spent at the hospital was 109 (range 13-253) days.
  
  
  CONCLUSIONS
  In our series the bladder preserving strategy does not confirm the optimistic results of other authors. The complications forced us to carry out a salvage cystectomy in nearly half of the cases. The other half of the patients complained of other severe complications reducing the quality of life of the remaining life span.
authors.affiliation: Department of Urology, General Hospital of Bolzano, Lorenz Böhler Street 5, 39100 Bolzano, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Lodde
authors.forename: Salvatore
authors.initials: S
authors.lastname: Palermo
authors.forename: Evi
authors.initials: E
authors.lastname: Comploj
authors.forename: Diego
authors.initials: D
authors.lastname: Signorello
authors.forename: Christine
authors.initials: C
authors.lastname: Mian
authors.forename: Lukas
authors.initials: L
authors.lastname: Lusuardi
authors.forename: Elena
authors.initials: E
authors.lastname: Longhi
authors.forename: Peter
authors.initials: P
authors.lastname: Zanon
authors.forename: Michael
authors.initials: M
authors.lastname: Mian
authors.forename: Armin
authors.initials: A
authors.lastname: Pycha
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D003131:Combined Modality Therapy; D015653:Cystectomy / Q000379:methods*; D003558:Cystoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D011446:Prospective Studies; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*