Type I polyketide synthases may have evolved through horizontal gene transfer.
Type I polyketide synthases (PKSI) are modular multidomain enzymes involved in the biosynthesis of many natural products of industrial interest. PKSI modules are minimally organized in three domains: ketosynthase (KS), acyltransferase (AT), and acyl carrier protein. The KS domain phylogeny of 23 PKSI clusters was determined. The results obtained suggest that many horizontal transfers of PKSI genes have occurred between actinomycetales species. Such gene transfers may explain the homogeneity and the robustness of the actinomycetales group since gene transfers between closely related species could mimic patterns generated by vertical inheritance. We suggest that the linearity and instability of actinomycetales chromosomes associated with their large quantity of genetic mobile elements have favored such horizontal gene transfers.
Ginolhac
Aurélien
A
LibraGen S.A., Bâtiment Canal Biotech 1, 3 rue des Satellites, 31400, Toulouse, France. contact@libragen.com
Jarrin
Cyrille
C
Robe
Patrick
P
Perrière
Guy
G
Vogel
Timothy M
TM
Simonet
Pascal
P
Nalin
Renaud
R
D000217:Acyltransferases / Q000235:genetics; D000666:Amphotericin B / Q000494:pharmacology; D001426:Bacterial Proteins / Q000378:metabolism; D019143:Evolution, Molecular; D018014:Gene Transfer Techniques; D022761:Gene Transfer, Horizontal; D005798:Genes, Bacterial; D018942:Macrolides / Q000494:pharmacology; D008957:Models, Genetic; D005810:Multigene Family; D010866:Natamycin / Q000494:pharmacology; D009761:Nystatin / Q000494:pharmacology; D010802:Phylogeny; D048630:Polyketide Synthases / Q000737:chemistry* / Q000378:metabolism*; D017434:Protein Structure, Tertiary
D001426:Bacterial Proteins; D018942:Macrolides; C086151:soraphen A; D009761:Nystatin; D048630:Polyketide Synthases; D000666:Amphotericin B; D010866:Natamycin; D000217:Acyltransferases