title: Pharmacokinetics and dosage regimen of ceftriaxone in E. coli lipopolysaccharide induced fever in buffalo calves.
abstract: The present study was planned to investigate the pharmacokinetics of ceftriaxone in experimentally induced febrile buffalo calves (n=5). The fever was induced by intravenous injection of E.coli lipopolysaccaride (1 microgram/kg). To study the pharmacokinetics, ceftriaxone was administered at the dose rate of 10 mg/kg body wt. in all animals. At 1 min, the peak concentration of ceftriaxone was 79.4+/-2.37 microgram/ml and the drug was detected up to 6 h. The elimination rate constant was 0.35+/-0.02 /h and elimination half-life was 2.04+/-0.14 h. The apparent volume of distribution (Vd(area)) and total body clearance (Cl(B)) were 1.21+/-0.15 l/kg and 0.41+/-0.03 l/kg/h, respectively. To maintain a minimum therapeutic concentration of 1 microgram/kg, a satisfactory dosage regimen of cefriaxone in febrile buffalo calves is 19 mg/kg followed by 18 mg/kg at 8 h intervals.
authors.affiliation: Department of Pharmacology and Toxicology, College of Veterinary Sciences, Punjab Agricultural University, Ludhiana-141004, India.
authors.forename: Manmohan Singh
authors.initials: MS
authors.lastname: Dardi
authors.forename: Suresh Kumar
authors.initials: SK
authors.lastname: Sharma
authors.forename: Anil Kumar
authors.initials: AK
authors.lastname: Srivastava
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002020:Buffaloes / Q000378:metabolism*; D002443:Ceftriaxone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004334:Drug Administration Schedule / Q000662:veterinary; D005334:Fever / Q000188:drug therapy / Q000378:metabolism* / Q000662:veterinary*; D006207:Half-Life; D008070:Lipopolysaccharides / Q000008:administration & dosage; D008297:Male; D008657:Metabolic Clearance Rate
chemical_list: D000900:Anti-Bacterial Agents; D008070:Lipopolysaccharides; D002443:Ceftriaxone