The role of nitric oxide on glutaminergic modulation of dopaminergic activation.
Biochemical studies have been demonstrated that N-methyl-D-aspartate (NMDA)-evoked dopaminergic (DAergic) activation can be modulated by nitric oxide (NO) systems. Therefore, behavioral study was performed to characterize the role of NO on NMDA modulation of DAergic activation. It is well known that apomorphine induces climbing behaviors in mice by the activation of DAergic receptors. Our previous studies showed that NMDA receptor antagonists reduced apomorphine-induced climbing behaviors. It was reported that nitric oxide synthase (NOS) inhibitors reduced the apomorphine-induced climbing behaviors. In this experiment, NO donor restored the apomorphine-induced climbing behavior, which was inhibited by NMDA receptor antagonist. NOS inhibitor inhibited the apomorphine-induced climbing behavior, which was enhanced by NMDA receptor agonist. These results suggest that DAergic activation is regulated by both NMDA receptors and NO systems, and NO in the down-stream of NMDA receptors play an important role on the glutaminergic NMDA modulation of DAergic function.
Hong
Jin-Tae
JT
Department of Pharmacy, College of Pharmacy, Chungbuk National University, Cheongju 371-763, South Korea.
Kim
Hyoung-Chun
HC
Kim
Hack-Seang
HS
Lee
Yong-Moon
YM
Oh
Ki-Wan
KW
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D018491:Dopamine Agonists / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects*; D016202:N-Methylaspartate / Q000494:pharmacology; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000378:metabolism*; D020030:Nitric Oxide Donors / Q000494:pharmacology; D010396:Penicillamine / Q000031:analogs & derivatives / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology
D018491:Dopamine Agonists; D004791:Enzyme Inhibitors; D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D020030:Nitric Oxide Donors; D010879:Piperazines; C110881:S-nitro-N-acetylpenicillamine; D009569:Nitric Oxide; D016202:N-Methylaspartate; C050592:3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid; D010396:Penicillamine; D001058:Apomorphine; D019331:NG-Nitroarginine Methyl Ester