New water soluble pyrroloquinoline derivatives as new potential anticancer agents.
A new class of water soluble 3H-pyrrolo[3,2-f]quinoline derivatives has been synthesized and investigated as potential anticancer drugs. Water solubility profiles have been used to select the most promising derivatives. The novel compound 10, having two (2-diethylamino-ethyl) side chains linked through positions 3N and 9O, presents a suitable water solubility profile, and it was shown to exhibit cell growth inhibitory properties when tested against the in-house panel of cell lines, in particular those obtained from melanoma.
Ferlin
Maria Grazia
MG
Molecular Modeling Section, Department of Pharmaceutical Sciences, University of Padova, Via Marzolo, 5-35100 Padova, Italy.
Marzano
Christine
C
Dalla Via
Lisa
L
Chilin
Adriana
A
Zagotto
Giuseppe
G
Guiotto
Adriano
A
Moro
Stefano
S
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D012995:Solubility; D014867:Water / Q000737:chemistry*
D000970:Antineoplastic Agents; D011758:Pyrroles; D011804:Quinolines; C410406:pyrroloquinoline; D014867:Water