[Oxidative stress and control of catalase activity in Escherichia coli].
Oxidative stress is a disbalanse between ROS generation and detoxification resulting in their increased level. It is commonly recognized that E. coli is the most suitable model system for the investigation of cell response to oxidative stress. E. coli is an enterobacteria which has specialized regulatory system for defence against ROS. Catalase is the key enzyme of the adaptive response. E. coli produces two forms of catalase--bifunctional catalase-peroxidase HPI and monofuctional catalase HPII. They are different in structure, kinetics, physico-chemical properties etc. HPI and HPII forms are members of various regulons which are regulated by different environmental factors. In this review we have summarized the present knowledge on two catalase forms and control of regulons responsible for antioxidant defence in E. coli.
Semchyshyn
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HM
Lushchak
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D002374:Catalase / Q000378:metabolism*; D004926:Escherichia coli / Q000201:enzymology / Q000378:metabolism*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism
D017382:Reactive Oxygen Species; D002374:Catalase