title: Biological evaluation of Tyr6 and Ser7 modified drosocin analogues.
abstract: An array of analogues of the cationic antimicrobial peptide drosocin was synthesized containing substitutions of Tyr6 and Ser7 in order to increase the proteolytic stability. Stabilizing the N-terminus with unnatural amino acids increased the serum stability of analogues by almost a factor 30 over an 8 h period.
authors.affiliation: TNO Defense, Security and Safety, AA Rijswijk, The Netherlands.
authors.forename: Peter C
authors.initials: PC
authors.lastname: de Visser
authors.forename: Peter A V
authors.initials: PA
authors.lastname: van Hooft
authors.forename: Anne-Marij
authors.initials: AM
authors.lastname: de Vries
authors.forename: Ad
authors.initials: A
authors.lastname: de Jong
authors.forename: Gijsbert A
authors.initials: GA
authors.lastname: van der Marel
authors.forename: Herman S
authors.initials: HS
authors.lastname: Overkleeft
authors.forename: Daan
authors.initials: D
authors.lastname: Noort
mesh_terms: D000595:Amino Acid Sequence; D006020:Glycopeptides / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D012694:Serine / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014443:Tyrosine / Q000737:chemistry*
chemical_list: D006020:Glycopeptides; C082117:drosocin; D014443:Tyrosine; D012694:Serine