title: [An autopsied case of metastatic endocrine carcinoma of the pancreas with primary site difficult to identify].
abstract: A 40-year-old man suffering from right cheek swelling was first diagnosed with ameloblastoma or anaplastic poorly-differentiated carcinoma of the head and neck region. He received 2 courses of CDDP/TXT chemotherapy (cisplatin 75 mg/m2, docetaxel 80 mg/m2) and achieved a partial response, but his carcinoma of the pancreas recurred. He also achieved a partial response with 2 courses of CBDCA/TXL regimen (carboplatin AUC=6, paclitaxel 200 mg/m2), but later died from his progressive disease. The autopsy revealed a pathological diagnosis of metastatic endocrine carcinoma of the pancreas. This case was close to a cancer with an unknown primary (CUP) site, and several favorable sub-sets of CUP have been identified, which are responsive to systemic chemotherapy. Poorly-differentiated neuroendocrine carcinomas like this case are highly sensitive to chemotherapy, and a careful pathological diagnosis may clarify its sensitivity to chemotherapy and the prognosis.
authors.affiliation: Dept. of Medical Oncology, Cancer Institute Hospital.
authors.forename: Hisakazu
authors.initials: H
authors.lastname: Nishimori
authors.forename: Shunji
authors.initials: S
authors.lastname: Takahashi
authors.forename: Eijiro
authors.initials: E
authors.lastname: Nagasaki
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yokoyama
authors.forename: Eiji
authors.initials: E
authors.lastname: Shinozaki
authors.forename: Yuko
authors.initials: Y
authors.lastname: Mishima
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Terui
authors.forename: Keisyo
authors.initials: K
authors.lastname: Chin
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Mizunuma
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Ito
authors.forename: Kentaro
authors.initials: K
authors.lastname: Inamura
authors.forename: Kiyohiko
authors.initials: K
authors.lastname: Hatake
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage; D002277:Carcinoma / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D002945:Cisplatin / Q000008:administration & dosage; D000077143:Docetaxel; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009362:Neoplasm Metastasis; D009382:Neoplasms, Unknown Primary / Q000473:pathology*; D017239:Paclitaxel / Q000008:administration & dosage; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D016190:Carboplatin; D017239:Paclitaxel; D002945:Cisplatin