Coeliac disease in children.
Although coeliac disease (CD) can present at any age, including the elderly, typical cases often manifest in early childhood. The clinical spectrum in children is wide and includes: (1) typical cases presenting early in life with signs of intestinal malabsorption (chronic diarrhea, weight loss, abdominal distention, etc); (2) atypical cases showing milder, often extra-intestinal, symptoms; (3) silent cases that are occasionally discovered because of serological screening; (4) potential/latent cases showing isolated positivity of coeliac serology at first testing and eventually the typical intestinal damage later in life. Many CD-associated problems, which were originally described mostly in adults, can indeed be observed in children or adolescents, e.g. reduced bone mineral density, neurological problems and associated autoimmune disorders. It is instrumental that both primary pediatricians and pediatric subspecialists have a high degree of awareness and embrace a 'liberal' use of serological CD tests in order to identify these cases in a timely fashion to prevent serious complications secondary to untreated CD.
Fasano
Alessio
A
School of Medicine, Mucosal Biology Research Center and Center for Celiac Research, University of Maryland, 22 S. Pine St HSFII Building, Room 345, Baltimore, MD 21201, USA. afasano@mbrc.umaryland.edu
Catassi
Carlo
C
D002446:Celiac Disease / Q000175:diagnosis* / Q000453:epidemiology; D002648:Child; D002986:Clinical Trials as Topic; D006801:Humans; D012698:Serologic Tests