title: The effect of HMG and recombinant human FSH on oocyte quality: a randomized single-blind clinical trial.
abstract: OBJECTIVE
  To compare the effect of HMG and rhFSH on oocyte quality in ICSI cycle.
  
  
  METHODS
  Vali-e-Asr university teaching hospital.
  
  
  METHODS
  Prospective single-blind randomized clinical trial.
  
  
  METHODS
  Sixty women undergoing ovarian stimulation for ICSI were randomized to receive a standard protocol of either HMG or rhFSH in down-regulation cycles.
  
  
  METHODS
  Prior to microinjection, each oocyte was assessed regarding the nuclear maturity, morphology of zona plucida, cytoplasmic appearance and polar body morphology. Fertilization rate was followed.
  
  
  RESULTS
  The percentage of metaphase II oocytes in HMG and rhFSH groups.
  
  
  METHODS
  Statistical analyses were carried out by the Mann-Whitney, Fisher's exact, chi2 tests and Student's t-test.
  
  
  RESULTS
  No significant differences were found between two groups in regard to the demographic data, the ovarian response and pregnancy/implantation rates (P>0.05). The percentage of metaphase II oocytes in HMG and rhFSH groups were 81.3% versus 80.6%, respectively.
  
  
  CONCLUSIONS
  There were no significant differences between parameters such as, oocyte quality and percentage of metaphase II oocytes between these two groups.
authors.affiliation: Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Imam Khomeini Hospital Complex, Keshavarz Blvd., Tehran 14194, Iran.
authors.forename: Batool Hossein
authors.initials: BH
authors.lastname: Rashidi
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Sarvi
authors.forename: Ensieh Shahrokh
authors.initials: ES
authors.lastname: Tehrani
authors.forename: Farid
authors.initials: F
authors.lastname: Zayeri
authors.forename: Mansoureh
authors.initials: M
authors.lastname: Movahedin
authors.forename: Navid
authors.initials: N
authors.lastname: Khanafshar
mesh_terms: D000328:Adult; D010064:Embryo Implantation; D004624:Embryo Transfer; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage*; D006801:Humans; D008596:Menotropins / Q000008:administration & dosage*; D008845:Microinjections; D009865:Oocytes / Q000187:drug effects*; D010062:Ovulation Induction; D011247:Pregnancy; D011446:Prospective Studies; D011994:Recombinant Proteins
chemical_list: D011994:Recombinant Proteins; D008596:Menotropins; D005640:Follicle Stimulating Hormone