A novel, mouse mammary tumor virus encoded protein with Rev-like properties.
We have identified a novel, multiple spliced, subgenomic mRNA species in MMTV producing cells of different origin containing an open reading frame encoding a 39-kDa Rev-like protein, Rem (regulator of expression of MMTV). An EGFP-Rem fusion protein is shown to be predominantly in the nucleolus. Further leptomycin B inhibits the nuclear export of nonspliced MMTV transcripts, implicating Rem in nuclear export by the Crm1 pathway in MMTV. Rem is thus reminiscent of the Rec protein from the related endogenous human retrovirus, HERV-K.
Indik
Stanislav
S
Research Institute for Virology and Biomedicine, University of Veterinary Medicine, Austria.
Günzburg
Walter H
WH
Salmons
Brian
B
Rouault
Francoise
F
D000818:Animals; D002460:Cell Line; D015967:Gene Expression Regulation, Viral; D015694:Gene Products, rev / Q000235:genetics / Q000378:metabolism*; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D012326:RNA Splicing; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism*
D015694:Gene Products, rev; D014764:Viral Proteins