Granisetron attenuates exercise-induced conditioned taste aversion in the rat.
A conditioned taste aversion (CTA) paradigm was used in the present study to investigate whether CTA produced by exercise could be attenuated by the 5-HT(3) receptor antagonist granisetron. Male Sprague-Dawley rats were randomly allocated to one of four groups (Ns=6) and were exposed to salty (0.128 M sodium chloride) or sour (0.00138M citric acid) solutions. Subjects were injected with either saline solution (1.0 ml, 0.9%) or granisetron (0.5mg/kg, IP) and were exposed to 30 min of forced wheel running exercise (70 revolutions/30min) 10 min after injection. Exercise induced CTA to both the salty (3.7 ml intake) and sour-flaroured (3.1ml intake) solutions as compared with no exercise (intake 14.0 and 13.7 ml), and administration of granisetron significantly attenuated the exercise-induced CTA to the salty- and sour-flavoured solutions.
Eccles
S
S
School of Psychology, University of Ulster (Jordanstown), Shore Road, Newtownabbey, Co. Antrim BT37 OQB, Northern Ireland.
Kim
E-M
EM
O'Hare
E
E
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D017829:Granisetron / Q000494:pharmacology*; D008297:Male; D010805:Physical Conditioning, Animal; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013649:Taste / Q000187:drug effects*
D017829:Granisetron; D012702:Serotonin Antagonists