Genetic deletion of CB1 receptors improves non-associative learning.
Habituation (a form of non-associative learning) was measured by assessing locomotion in novel activity monitors in CB1 receptor knockout mice and juxtaposed to habituation measured in muscarinic M2, M4, and double M2/M4 receptor knockout mice. M2 and M2/M4, but not M4, receptor knockout mice appeared to have an impaired ability to habituate, whereas CB1 receptor knockout mice showed enhanced habituation compared to wild-type animals. We conclude that CB1 receptor gene invalidation improves habituation tentatively through an increase in cholinergic neurotransmission.
Degroot
Aldemar
A
Eli Lilly and Company, Lilly Corporate Center, Neuroscience Discovery Research, Indianapolis, IN 46285-0510, USA.
Salhoff
Craig
C
Davis
Richard J
RJ
Nomikos
George G
GG
D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal; D005260:Female; D017353:Gene Deletion; D006185:Habituation, Psychophysiologic / Q000502:physiology*; D008124:Locomotion / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D043884:Receptor, Cannabinoid, CB1 / Q000172:deficiency* / Q000235:genetics / Q000502:physiology; D011976:Receptors, Muscarinic / Q000145:classification / Q000172:deficiency / Q000235:genetics; D013997:Time Factors
D043884:Receptor, Cannabinoid, CB1; D011976:Receptors, Muscarinic