[Expression of Fas antigen and ligand, placental growth factor in placenta of pregnant women with pre-eclampsia].
OBJECTIVE
To investigate the expression of Fas antigen (Fas) and ligand (FasL), placental growth factor (PlGF) in placenta of pregnant women with pre-eclampsia.


METHODS
Expressions of Fas, FasL and PlGF of placenta were determined by immunohistological streptavidin-peroxidase-biotin (SP) method and compared between normal late pregnancy (24 cases) and mild pre-eclampsia (24 cases) and severe pre-eclampsia (24 cases) groups.


RESULTS
Different expression of levels Fas, FasL and PlGF were observed in the trophoblasts of most placentae. Positive immunostain of Fas, FasL and PlGF was mainly located in the cytoplasm and membrane of syncytiotrophoblast. FasL and PlGF expressions (63 +/- 4, 81 +/- 6 and 42 +/- 6, 65 +/- 6) were significantly less (P < 0.01), and Fas expression (51 +/- 4, 67 +/- 6) significantly greater in the study subjects compared with controls (P < 0.01).


CONCLUSIONS
Altered expression of Fas and FasL in trophoblasts of placenta may influence pathogenesis or sequelate of pre-eclampsia.
Yue
Xiu-yun
XY
Department of Obstetrics and Gynecology, Third Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
Zhang
Xi
X
Cui
Shi-hong
SH
Wang
Xiu-qin
XQ
D000328:Adult; D053222:Fas Ligand Protein / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D006801:Humans; D010920:Placenta / Q000378:metabolism; D000072483:Placenta Growth Factor; D011225:Pre-Eclampsia / Q000235:genetics* / Q000378:metabolism; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000235:genetics* / Q000378:metabolism; D014327:Trophoblasts / Q000378:metabolism; D019014:fas Receptor / Q000235:genetics* / Q000378:metabolism
D053222:Fas Ligand Protein; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D019014:fas Receptor; D000072483:Placenta Growth Factor