An array of possibilities for the study of autoimmunity.
Since the completion of the sequencing of the human genome, scientific focus has shifted from studying genes to analysing the much larger number of proteins encoded by them. Several proteins can be generated from a single gene depending on how the genetic information is read (transcribed) and how the resultant protein is modified following translation (post-translational modification). Genomic and proteomic technologies are already providing useful information about autoimmune disease, and they are likely to lead to important discoveries within the next decade.
Fathman
C Garrison
CG
Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California 94305, USA. cfathman@stanford.edu
Soares
Luis
L
Chan
Steven M
SM
Utz
Paul J
PJ
D000906:Antibodies / Q000032:analysis / Q000276:immunology; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D015551:Autoimmunity / Q000235:genetics* / Q000276:immunology*; D005434:Flow Cytometry; D023281:Genomics / Q000379:methods*; D006801:Humans; D040901:Proteomics / Q000379:methods*
D000906:Antibodies