title: [Features of regional spread of supraglottic larynx cancer].
abstract: Development of adequate methods for surgical regional control in supraglottic cancer is one of the most important issues in the management of this disease. The retrospective analysis of 863 patients with supraglottic cancer was conducted. The main clinical and pathological factors influencing the metastatic process were studied. According to the study results the supraglottic cancer most frequently had metastasis in the group I-III lymph nodes. The frequency of regional involvement was high in the period of 6 months after the tumor occurrence and especially increased after 12 months, which indicates to tumor aggressiveness. The possibility of regional metastases increases with the raising of T criteria. The endophytic and mixed growth pattern tumors had metastases with higher frequency compared to egsophytic tumors. The tumor ulceration and low differentiation correlated with high frequency of regional metastases.
authors.affiliation: National Center of Oncology, Tbilisi, Georgia.
authors.forename: L
authors.initials: L
authors.lastname: Kalmakhelidze
authors.forename: K
authors.initials: K
authors.lastname: Mardaleishvili
mesh_terms: D002454:Cell Differentiation; D018450:Disease Progression; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D009333:Neck; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D012189:Retrospective Studies