Neuronal death induced by endogenous extracellular ATP in retinal cholinergic neuron density control.
The precise assembly of neuronal circuits requires that the correct number of pre- and postsynaptic neurons form synaptic connections. Neuronal cell number is thus tightly controlled by cell death during development. Investigating the regulation of cell number in the retina we found an ATP gated mechanism of neuronal death control. By degrading endogenous extracellular ATP or blocking the P2X(7) ATP receptors we found that endogenous extracellular ATP triggers the death of retinal cholinergic neurons during normal development. ATP-induced death eliminates cholinergic cells too close to one another, thereby controlling the total number, the local density and the regular spacing of these neurons.
Resta
Valentina
V
Istituto di Neuroscienze CNR-56100 Pisa, Italy.
Novelli
Elena
E
Di Virgilio
Francesco
F
Galli-Resta
Lucia
L
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D002452:Cell Count; D016923:Cell Death / Q000187:drug effects; D009474:Neurons / Q000166:cytology* / Q000187:drug effects*; D051381:Rats; D020318:Rats, Long-Evans; D018048:Receptors, Purinergic P2 / Q000378:metabolism; D058486:Receptors, Purinergic P2X7; D012160:Retina / Q000166:cytology* / Q000187:drug effects* / Q000196:embryology; D015398:Signal Transduction / Q000187:drug effects
D018048:Receptors, Purinergic P2; D058486:Receptors, Purinergic P2X7; D000255:Adenosine Triphosphate