[The biochemical changes of hippocampus in patients before and after denture restoration: a preliminary 1H-magnetic resonance spectroscopy study].
OBJECTIVE
To study the effects of reconstruction of lost occlusal support on the biochemical changes of nervous system.


METHODS
The changes of central nervous system metabolic compounds within hippocampus body were measured with proton magnetic resonance spectroscopy ((1)HMRS) before and after denture restoration (six weeks) in seven patients with prolonged loss of occlusal support.


RESULTS
(1)HMRS indicated that Cho/Cr decreased by 11.9% (P < 0.05) six weeks after denture restoration, MI/Cr decreased by 28.8% (P < 0.05), and NAA/CR increased by 4.8% (P > 0.05) within hippocampus body.


CONCLUSIONS
Recovery of occlusal support facilitates improvement of neuron functions in patients' hippocampus, which may help improve the functions of nervous system.
Jiang
Qing-song
QS
Department of Stomatology, Beijing Anzhen Hospital, Capital University of Medical Sciences, Beijing 100029, China.
Jiang
Ting
T
Jin
Zhen
Z
Feng
Hai-lan
HL
Zeng
Ya-wei
YW
Li
Jian
J
D000368:Aged; D000369:Aged, 80 and over; D003832:Denture, Partial, Removable; D005260:Female; D006624:Hippocampus / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D016388:Tooth Loss / Q000378:metabolism* / Q000628:therapy