Thiobarbituric acid reactive substances in the cerebrospinal fluid in schizophrenia.
Increased levels of lipid peroxidation products (thiobarbituric acid reactive substances [TBARS]) are reported in plasma/serum from patients with schizophrenia. CSF TBARS levels were assessed in 10 neuroleptic-free patients with schizophrenia and in 9 normal controls. Controlling for duration of storage, CSF TBARS content was significantly lower in patients with schizophrenia vs. controls (p<0.002). No significant correlations were found between CSF TBARS and patients' age, gender, or duration of illness. The likely source of reported elevated plasma/serum TBARS in schizophrenia is therefore in the periphery. Degeneration of central neuronal membranes in schizophrenia is not supported by the present study.
Skinner
Andrew O
AO
Department of Psychiatry and Behavioral Science University of Louisville School of Medicine, KY 40222, USA.
Mahadik
Sahebarao P
SP
Garver
David L
DL
D014150:Antipsychotic Agents / Q000627:therapeutic use; D003124:Colorimetry; D005228:Fatty Acids, Essential / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D005260:Female; D005609:Free Radicals / Q000134:cerebrospinal fluid*; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D012016:Reference Values; D012559:Schizophrenia / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000188:drug therapy; D013570:Synaptic Membranes / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism*
D014150:Antipsychotic Agents; D005228:Fatty Acids, Essential; D005231:Fatty Acids, Unsaturated; D005609:Free Radicals; D008563:Membrane Lipids; D017392:Thiobarbituric Acid Reactive Substances