title: Merosesquiterpenes from two sponges of the genus Dysidea.
abstract: The chemical study of two sponges of the genus Dysidea collected in the Gulf of California has led to the isolation of the new merosesquiterpenes 20-O-acetyl-21-hydroxy-ent-isozonarol (2), 20-O-acetylneoavarol (3), ent-yahazunol (4), and dysienone (5), together with the known compounds 1 and 6-9. The structures of the new metabolites have been established by spectroscopic techniques. The absolute configuration of compounds 5 and 6 has been investigated by application of a procedure developed by Riguera et al. Compounds 2 and 5 showed cytotoxic activity against three human tumor cell lines.
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias del Mar y Ambientales, Universidad de Cádiz, Apartado 40, 11510-Puerto Real (Cádiz), Spain.
authors.forename: Esteban
authors.initials: E
authors.lastname: Pérez-García
authors.forename: Eva
authors.initials: E
authors.lastname: Zubía
authors.forename: María J
authors.initials: MJ
authors.lastname: Ortega
authors.forename: J Luis
authors.initials: JL
authors.lastname: Carballo
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002140:California; D004354:Drug Screening Assays, Antitumor; D047088:Dysidea / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D012717:Sesquiterpenes