title: Regional left ventricular perfusion and function in patients presenting to the emergency department with chest pain and no ST-segment elevation.
abstract: OBJECTIVE
  We hypothesized that the assessment of left ventricular regional function (RF) and myocardial perfusion (MP) will provide incremental value over routine evaluation in patients who present to the emergency department (ED) with chest pain (CP) and no ST-segment elevation.
  
  
  RESULTS
  In addition to routine clinical evaluation, patients with suspected cardiac CP and no ST-segment elevation were evaluated in the ED for RF and MP using contrast echocardiography (CE). Cardiac-related death, acute myocardial infarction, unstable angina pectoris, congestive heart failure (CHF), and revascularization were considered as events within 48 h (early). Of the 1017 patients studied, 166 (16.3%) had early events. Adding RF increased the prognostic information of clinical and EKG variables significantly (Bonferroni corrected P<0.0001) for predicting these events. When MP was added, significant additional prognostic information was obtained (Bonferroni corrected P=0.0002). All patients were followed for a median of 7.7 months (25th-75th percentiles: 2.7-12.5) Of these, 292 (28.7%) had events. Adding RF increased the prognostic information of clinical and EKG variables for determining the risk of events significantly (Bonferroni corrected P<0.0001), which was further increased by adding MP (Bonferroni corrected P<0.0001).
  
  
  CONCLUSIONS
  Early assessment of RF on CE adds significant diagnostic and prognostic value to routine evaluation in patients presenting to the ED with suspected cardiac CP and no ST-segment elevation. MP provides additional significant value. CE could be a valuable tool in the early triage and management of CP patients presenting to the ED.
authors.affiliation: The Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia, Medical Center, Charlottesville, VA 22908-0158, USA.
authors.forename: Diana
authors.initials: D
authors.lastname: Rinkevich
authors.forename: Sanjiv
authors.initials: S
authors.lastname: Kaul
authors.forename: Xin-Qun
authors.initials: XQ
authors.lastname: Wang
authors.forename: Khim Leng
authors.initials: KL
authors.lastname: Tong
authors.forename: Todd
authors.initials: T
authors.lastname: Belcik
authors.forename: Saul
authors.initials: S
authors.lastname: Kalvaitis
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Lepper
authors.forename: John M
authors.initials: JM
authors.lastname: Dent
authors.forename: Kevin
authors.initials: K
authors.lastname: Wei
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000706:statistics & numerical data; D002637:Chest Pain / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001026:Coronary Artery Bypass / Q000706:statistics & numerical data; D003326:Coronary Circulation; D004562:Electrocardiography; D004636:Emergency Service, Hospital; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology / Q000628:therapy; D011379:Prognosis; D011446:Prospective Studies; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology