title: Italian clinical research in non-small-cell lung cancer.
abstract: Lung cancer is the most common cause of cancer deaths in both men and women worldwide and has a poor prognosis. Non-small-cell lung cancer (NSCLC) represents approximately 80% of all lung cancers. Surgery is the only curative treatment of NSCLC but only 15-20% of tumours can be radically resected with a survival of about 40% at 5 years. Considering these disappointing results NSCLC is one of the most frequent subjects of clinical research worldwide. Italy is playing an important role in the clinical research of NSCLC performing phase I, II and III trials, prevalently by cooperative groups, and achieving important results that contributed to define the standard treatment for NSCLC patients. In particular, Italy is leader in the clinical research of the treatment of advanced NSCLC elderly patients. Today, large controlled clinical trials are ongoing. In this paper we analyse and discuss the main trials performed by Italian groups in the fields of NSCLC.
authors.affiliation: Division of Medical Oncology, S.G. Moscati Hospital, Avellino, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Gridelli
authors.forename: A
authors.initials: A
authors.lastname: Rossi
authors.forename: D
authors.initials: D
authors.lastname: Galetta
authors.forename: P
authors.initials: P
authors.lastname: Maione
authors.forename: C
authors.initials: C
authors.lastname: Ferrara
authors.forename: C
authors.initials: C
authors.lastname: Guerriero
authors.forename: F
authors.initials: F
authors.lastname: Del Gaizo
authors.forename: D
authors.initials: D
authors.lastname: Nicolella
authors.forename: G
authors.initials: G
authors.lastname: Colantuoni
authors.forename: V
authors.initials: V
authors.lastname: Gebbia
authors.forename: G
authors.initials: G
authors.lastname: Colucci
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D002986:Clinical Trials as Topic / Q000379:methods; D005260:Female; D006801:Humans; D007558:Italy; D008175:Lung Neoplasms / Q000401:mortality / Q000628:therapy*; D008297:Male; D018714:Radiotherapy, Adjuvant; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D002945:Cisplatin