Discovery of genetic difference between asthmatic children with high IgE level and normal IgE level by whole genome linkage disequilibrium mapping using 763 autosomal STR markers.
The genome-wide linkage disequilibrium screen for loci associated with genetic difference between allergic and nonallergic asthma was conducted with 763 autosomal STR markers and included 190 asthmatic children. Evidence for association with differences between the two forms of asthma was observed for 36 STR markers. Marker-to-marker synergetic effect and by simulation resampling tests revealed D5S2011, D6S305, and D9S286 were important loci in allergic asthma while D6S1574, D8S1769, and D19S226 were important in nonallergic asthma. Our results show strong genetic evidence that these markers play an important role in defining allergic and nonallergic asthma and provides important candidates of susceptible genes in these two categories of asthma. This study further shows that asthma is, indeed, a heterogeneous group of underlying diseases and, although with similar clinical phenotypes, may have different clinical severities, outcomes, and need more tailor-made management.
Wang
Jiu-Yao
JY
Department of Pediatrics, Institute of Molecular Medicine, College of Medicine, National Cheng-Kung University, Tainan, Taiwan.
Lin
Cherry Guan-Ju
CG
Research Development Division, Vita Genomics Inc., 7Fl., No. 6, Sec. 1, Jungshing Rd., Taipei County, Wugu Shiang, 248, Taiwan.
Bey
Monica Shian-Jy
MS
Research Development Division, Vita Genomics Inc., 7Fl., No. 6, Sec. 1, Jungshing Rd., Taipei County, Wugu Shiang, 248, Taiwan.
Wang
Lingmei
L
Research Development Division, Vita Genomics Inc., 7Fl., No. 6, Sec. 1, Jungshing Rd., Taipei County, Wugu Shiang, 248, Taiwan.|Division of Molecular and Genomic Medicine, National Health Research Institutes, Taipei, Taiwan.
Lin
Felicia Yi-Fang
FY
Research Development Division, Vita Genomics Inc., 7Fl., No. 6, Sec. 1, Jungshing Rd., Taipei County, Wugu Shiang, 248, Taiwan.
Huang
Lichih
L
Research Development Division, Vita Genomics Inc., 7Fl., No. 6, Sec. 1, Jungshing Rd., Taipei County, Wugu Shiang, 248, Taiwan.
Wu
Lawrence Shih-Hsin
LS
Research Development Division, Vita Genomics Inc., 7Fl., No. 6, Sec. 1, Jungshing Rd., Taipei County, Wugu Shiang, 248, Taiwan. lawrence.wu@vitagenomics.com.
D001249:Asthma / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism; D002648:Child; D002874:Chromosome Mapping; D003198:Computer Simulation; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000235:genetics*; D007073:Immunoglobulin E / Q000378:metabolism*; D015810:Linkage Disequilibrium; D018895:Microsatellite Repeats; D020080:Tandem Repeat Sequences
D005819:Genetic Markers; D007073:Immunoglobulin E