title: Simultaneous type 1 diabetes onset in mother and son coincident with an enteroviral infection.
abstract: Enterovirus (EV) infections have been implicated in the development of type 1 diabetes. (T1D). They may cause beta-cell destruction either by cytolytic infection of the cells or indirectly by triggering the autoimmune response. Virus was isolated from a woman at diagnosis of T1D (Tuvemo 1) and in addition, virus was isolated from her son at diagnosis of T1D at the same day (Tuvemo 2). None of the isolates could initially be serotyped by conventional methods. The Tuvemo 1 virus was genotyped and after sub-cultivation it was also serotyped as Coxsackievirus B5. The mother revealed antibodies against GAD65. The boy and the father both revealed a significant increase in neutralization antibody titre against two strains of CBV-4, clearly indicating a recent or ongoing EV infection. In addition, the brother showed such a titre rise against another CBV-4 strain (E2) and against a CBV-5 strain (4429). These results show that the whole family had a proven EV infection at the time of T1D diagnosis of the mother and the 10-years-old boy, indicating that the infection might cause or accelerate the T1D.
authors.affiliation: Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Maria
authors.initials: M
authors.lastname: Hindersson
authors.forename: Hindersson
authors.initials: H
authors.lastname: Maria
authors.forename: Asma
authors.initials: A
authors.lastname: Elshebani
authors.forename: Anders
authors.initials: A
authors.lastname: Orn
authors.forename: Orn
authors.initials: O
authors.lastname: Anders
authors.forename: Torsten
authors.initials: T
authors.lastname: Tuvemo
authors.forename: Tuvemo
authors.initials: T
authors.lastname: Torsten
authors.forename: Gun
authors.initials: G
authors.lastname: Frisk
authors.forename: Frisk
authors.initials: F
authors.lastname: Gun
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D003384:Coxsackievirus Infections / Q000150:complications / Q000175:diagnosis / Q000821:virology; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000209:etiology*; D029822:Enterovirus B, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification / Q000502:physiology; D004769:Enterovirus Infections / Q000150:complications* / Q000175:diagnosis / Q000821:virology; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D009500:Neutralization Tests; D009679:Nuclear Family; D012367:RNA, Viral / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013548:Sweden
chemical_list: D000914:Antibodies, Viral; D012367:RNA, Viral