Striatal dopamine during sensorial stimulations: a [18F]FDOPA PET study in human and cats.
Sensory stimulations of the forelimb in cats are known to increase dopamine release in the ipsilateral striatum and to decrease it in the homologous contralateral structure. Using positron emission tomography in both humans and cats, the present study shows that such sensory stimulations greatly reduce [(18)F]FDOPA accumulation ipsilateral to the stimulation (by 40.4% and 26.4% in the human caudate and putamen, respectively, and by 33.3% in the cat striatum). This decrease in striatal [(18)F]FDOPA uptake suggests a reduced DA storage resulting from the increased amine release. No change was observed in the contralateral striatum in neither human or cat suggesting, in contrast, that [(18)F]FDOPA accumulation is not facilitated by decreased DA release. These results support the hypothesis that sensory stimulations activate a non-synaptic mode of dopamine release.
Hassoun
Wadad
W
Physiologie Integrative Cellulaire et Moléculaire, CNRS UMR5123, Villeurbanne, France.
Thobois
Stephane
S
Ginovart
Nathalie
N
Garcia-Larrea
Luis
L
Cavorsin
Marion Le
ML
Guillouet
Stephane
S
Bonnefoi
Frederic
F
Costes
Nicolas
N
Lavenne
Frank
F
Martin
Jean Pierre
JP
Broussolle
Emmanuel
E
Leviel
Vincent
V
D000328:Adult; D000818:Animals; D002415:Cats; D003342:Corpus Striatum / Q000000981:diagnostic imaging* / Q000378:metabolism*; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D008875:Middle Aged; D010812:Physical Stimulation / Q000379:methods; D049268:Positron-Emission Tomography
D005462:Fluorine Radioisotopes; C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine; D004298:Dopamine