Live attenuated mutants of Mycobacterium tuberculosis as candidate vaccines against tuberculosis.
The recent advances in genetic tools to manipulate Mycobacterium tuberculosis have led to the construction of defined mutants and to the study of their role in the virulence and pathogenesis of tuberculosis. The safety and vaccine potential of a few of these M. tuberculosis mutants as candidate vaccines against tuberculosis are discussed.
Sambandamurthy
Vasan K
VK
Department of Microbiology and Immunology, Howard Hughes Medical Institute, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Jacobs
William R
WR
D000818:Animals; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000276:immunology; D014376:Tuberculosis / Q000517:prevention & control; D032581:Tuberculosis Vaccines / Q000276:immunology / Q000633:toxicity; D014613:Vaccines, Attenuated / Q000276:immunology / Q000633:toxicity
D032581:Tuberculosis Vaccines; D014613:Vaccines, Attenuated