title: Benzophenones from Hypericum carinatum.
abstract: Two new benzophenones were isolated from the leaves of Hypericum carinatum. Their structures were established on the basis of 2D NMR spectroscopic analyses and mass spectrometry as cariphenone A (6-benzoyl-5,7-dihydroxy-2,2,8-trimethyl-2H-chromene) (1) and cariphenone B (8-benzoyl-5,7-dihydroxy-2,2,6-trimethyl-2H-chromene) (2). Five known compounds, the phloroglucinol derivative uliginosin B (3), 1-eicosanol, sitosterol, stigmasterol, and campesterol, were also characterized. Compounds 1-3 were evaluated for their total antioxidant capacity through a total radical-trapping parameter assay. Only compound 1 showed moderate antioxidant activity, exhibiting inhibition of chemiluminescence similar to that of quercetin at the same concentration.
authors.affiliation: Programa de Pós Graduação em Ciências Farmacêuticas, UFRGS, Avenida Ipiranga, 2752, 90610-000 Porto Alegre, RS, Brazil.
authors.forename: Ana Paula M
authors.initials: AP
authors.lastname: Bernardi
authors.forename: Alexandre B F
authors.initials: AB
authors.lastname: Ferraz
authors.forename: Daniela V
authors.initials: DV
authors.lastname: Albring
authors.forename: Sérgio A L
authors.initials: SA
authors.lastname: Bordignon
authors.forename: Jan
authors.initials: J
authors.lastname: Schripsema
authors.forename: Raquel
authors.initials: R
authors.lastname: Bridi
authors.forename: Carlos Severo
authors.initials: CS
authors.lastname: Dutra-Filho
authors.forename: Amélia T
authors.initials: AT
authors.lastname: Henriques
authors.forename: Gilsane Lino
authors.initials: GL
authors.lastname: von Poser
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001577:Benzophenones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001938:Brazil; D004305:Dose-Response Relationship, Drug; D020902:Hypericum / Q000737:chemistry*; D008163:Luminescent Measurements; D015394:Molecular Structure; D010696:Phloroglucinol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011794:Quercetin / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D001577:Benzophenones; C501806:cariphenone A; C501807:cariphenone B; D011794:Quercetin; D010696:Phloroglucinol