title: Comparative in vitro activities of investigational peptide deformylase inhibitor NVP LBM-415 and other agents against human mycoplasmas and ureaplasmas.
abstract: Peptide deformylase inhibitor LBM-415 and seven other drugs were tested against Mycoplasma pneumoniae (100 isolates), Mycoplasma hominis (20 isolates), Mycoplasma fermentans (10 isolates), and Ureaplasma species (50 isolates). LBM-415 was active against M. pneumoniae (MICs, <or=0.008 microg/ml). It showed no activity against M. hominis and M. fermentans and modest activity against Ureaplasma spp.
authors.affiliation: Department of Pathology, WP 230, 619 19th Street South, Birmingham, AL 35249, USA. waites@path.uab.edu
authors.forename: Ken B
authors.initials: KB
authors.lastname: Waites
authors.forename: Nipun B
authors.initials: NB
authors.lastname: Reddy
authors.forename: Donna M
authors.initials: DM
authors.lastname: Crabb
authors.forename: Lynn B
authors.initials: LB
authors.lastname: Duffy
mesh_terms: D000581:Amidohydrolases / Q000037:antagonists & inhibitors*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009174:Mycoplasma / Q000145:classification / Q000187:drug effects*; D016858:Mycoplasma fermentans / Q000187:drug effects; D019535:Mycoplasma hominis / Q000187:drug effects; D009177:Mycoplasma pneumoniae / Q000187:drug effects; D011480:Protease Inhibitors / Q000494:pharmacology*; D014509:Ureaplasma / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D011480:Protease Inhibitors; D000581:Amidohydrolases; C084507:peptide deformylase