[The significance of circulating microparticles in physiology, inflammatory and thrombotic diseases].
BACKGROUND
In multicellular organisms, apoptosis and subsequent microparticle shedding play a key role in homeostasis. Having long been considered as << cellular dust >>, microparticles released in biological fluids upon cell activation or apoptosis appear as multifunctional bioeffectors involved in the modulation of key functions including immunity, inflammation, hemostasis and thrombosis, angiogenesis. MP constitute reliable markers of vascular damage, accessible to biological detection whilst the cells they originate from remain sequestered in tissues or are promptly submitted to phagocytosis.


RESULTS
MP modulate biological functions of target cells through the transfer of cytoplasmic content, lipids and membrane receptors. The pharmacological modulation of circulating levels of microparticles could be of particular interest in thrombotic or inflammatory diseases, cancer or hemophilia.


CONCLUSIONS
MP can now be viewed not only as a hallmark of cell damage but also as a true biological tool.
Morel
O
O
Fédération de cardiologie des hôpitaux universitaires de Strasbourg, France. Olivier.Morel@chru-strasbourg.fr
Morel
N
N
Hugel
B
B
Jesel
L
L
Vinzio
S
S
Goichot
B
B
Bakouboula
B
B
Grunebaum
L
L
Freyssinet
J M
JM
Toti
F
F
D000328:Adult; D017209:Apoptosis / Q000502:physiology*; D015415:Biomarkers; D002450:Cell Communication / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology; D005260:Female; D006487:Hemostasis; D006706:Homeostasis; D006801:Humans; D007109:Immunity / Q000502:physiology; D007249:Inflammation / Q000503:physiopathology*; D008297:Male; D008830:Microbodies / Q000502:physiology; D010316:Particle Size; D010587:Phagocytosis; D010641:Phenotype; D011247:Pregnancy; D019087:Selectins / Q000502:physiology; D013925:Thromboplastin / Q000502:physiology*; D013927:Thrombosis / Q000503:physiopathology*
D015415:Biomarkers; D019087:Selectins; D013925:Thromboplastin