title: Cytotoxic arylnaphthalene lignans from a Vietnamese acanthaceae, Justicia patentiflora.
abstract: One new norlignan (1) and five new lignans (2-6) were isolated from the leaves and stems of Justicia patentiflora by a bioassay-guided purification. Five known compounds, carinatone, diphyllin, justicidin A, taiwanin E, and tuberculatin, were also found in J. patentiflora. Most of the new compounds display significant activity in in vitro cytotoxic assays against KB, HCT116, and MCF-7 cancer cell lines and arrest the cell cycle in the G0/G1 phase.
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Susplugas
authors.forename: Nguyen Van
authors.initials: NV
authors.lastname: Hung
authors.forename: Jérôme
authors.initials: J
authors.lastname: Bignon
authors.forename: Odile
authors.initials: O
authors.lastname: Thoison
authors.forename: Anna
authors.initials: A
authors.lastname: Kruczynski
authors.forename: Thierry
authors.initials: T
authors.lastname: Sévenet
authors.forename: Françoise
authors.initials: F
authors.lastname: Guéritte
mesh_terms: D027901:Acanthaceae / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D016193:G1 Phase / Q000187:drug effects; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D016192:Resting Phase, Cell Cycle / Q000187:drug effects; D014407:Tumor Cells, Cultured; D014744:Vietnam
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; C501783:justicinol; C501782:justiflorinol; C501784:patentiflorin A