title: Microwave-assisted synthesis of N,N'-diaryl cyanoguanidines.
abstract: [reaction: see text] A mild, efficient, and high-yielding method for the synthesis of N,N'-diaryl cyanoguanidines from their corresponding thioureas under microwave-assisted conditions is described. A series of cyanoguanidines were synthesized containing both electron-donating and electron-withdrawing substituents. The reactions were facilitated by the use of polar solvents along with moderate temperatures.
authors.affiliation: Department of Research, Guilford Pharmaceuticals, Inc., Baltimore, Maryland 21224, USA.
authors.forename: Sean K
authors.initials: SK
authors.lastname: Hamilton
authors.forename: Doug E
authors.initials: DE
authors.lastname: Wilkinson
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Hamilton
authors.forename: Yong-Qian
authors.initials: YQ
authors.lastname: Wu
mesh_terms: D002384:Catalysis; D006146:Guanidines / Q000138:chemical synthesis*; D008872:Microwaves; D015394:Molecular Structure; D013440:Sulfides / Q000138:chemical synthesis; D013696:Temperature
chemical_list: D006146:Guanidines; D013440:Sulfides; C004711:dicyandiamido