title: Accuracy of diagnostic imaging techniques in the diagnosis of aseptic loosening of the femoral component of a hip prosthesis: a meta-analysis.
abstract: In this meta-analysis we included 32 English-language articles published between January 1975 and June 2004 on the diagnostic performance of plain radiography, subtraction arthrography, nuclear arthrography and bone scintigraphy in detecting aseptic loosening of the femoral component, using criteria based on the Cochrane systematic review of screening and diagnostic tests. The mean sensitivity and specificity were, respectively, 82% (95% confidence interval (CI) 76 to 87) and 81% (95% CI 73 to 87) for plain radiography and 85% (95% CI 75 to 91) and 83% (95% CI 75 to 89) for nuclear arthrography. Pooled sensitivity and specificity were, respectively, 86% (95% CI 74 to 93) and 85% (95% CI 77 to 91) for subtraction arthrography and 85% (95% CI 79 to 89) and 72% (95% CI 64 to 79) for bone scintigraphy. Although the diagnostic performance of the imaging techniques was not significantly different, plain radiography and bone scintigraphy are preferred for the assessment of a femoral component because of their efficacy and lower risk of patient morbidity.
authors.affiliation: Department of Clinical Epidemiology and Biostatistics, VU University Medical Centre, Boelalaan 1117, 1007 MB Amsterdam, The Netherlands. opp.temmerman@vumc.nl
authors.forename: O P P
authors.initials: OP
authors.lastname: Temmerman
authors.forename: P G H M
authors.initials: PG
authors.lastname: Raijmakers
authors.forename: J
authors.initials: J
authors.lastname: Berkhof
authors.forename: O S
authors.initials: OS
authors.lastname: Hoekstra
authors.forename: G J J
authors.initials: GJ
authors.lastname: Teule
authors.forename: I C
authors.initials: IC
authors.lastname: Heyligers
mesh_terms: D001175:Arthrography / Q000379:methods; D019644:Arthroplasty, Replacement, Hip; D006621:Hip Joint / Q000000981:diagnostic imaging*; D006801:Humans; D011475:Prosthesis Failure; D012372:ROC Curve; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity