title: Fluoroquinolone-resistant Streptococcus agalactiae: epidemiology and mechanism of resistance.
abstract: Quinolone-resistant Streptococcus agalactiae bacteria were recovered from single-patient isolates and found to contain mutations in the gyrase and topoisomerase IV genes. Pulsed-field gel electrophoresis demonstrated that four isolates from the same long-term care facility were closely related; in seven cases, quinolone-resistant Haemophilus influenzae and S. agalactiae bacteria were isolated from the same patient.
authors.affiliation: Infectious Disease Section, Department of Medicine and Lang Research Center, New York Hospital Queens, 56-45 Main Street, Flushing, NY 11355, USA. WEW9004@nyp.org
authors.forename: Wehbeh
authors.initials: W
authors.lastname: Wehbeh
authors.forename: Roberto
authors.initials: R
authors.lastname: Rojas-Diaz
authors.forename: Xinying
authors.initials: X
authors.lastname: Li
authors.forename: Noriel
authors.initials: N
authors.lastname: Mariano
authors.forename: Louise
authors.initials: L
authors.lastname: Grenner
authors.forename: Sorana
authors.initials: S
authors.lastname: Segal-Maurer
authors.forename: Barbara
authors.initials: B
authors.lastname: Tommasulo
authors.forename: Karl
authors.initials: K
authors.lastname: Drlica
authors.forename: Carl
authors.initials: C
authors.lastname: Urban
authors.forename: James J
authors.initials: JJ
authors.lastname: Rahal
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000494:pharmacology*; D027081:DNA Gyrase / Q000235:genetics; D027101:DNA Topoisomerase IV / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D024841:Fluoroquinolones / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009154:Mutation; D013290:Streptococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D013292:Streptococcus agalactiae / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D027101:DNA Topoisomerase IV; D027081:DNA Gyrase