[High dose fibrinogen administration for acute therapy of coagulopathy during massive perioperative transfusion].
During acute and severe perioperative bleeding a coagulopathy due to depletion, consumption and dilution of clotting factors and thrombocytes may occur. Diagnosis and therapy of such a coagulopathy should take place immediately. We report two cases of acute coagulopathy during perioperative bleeding and massive transfusion, which were treated successfully by administration of high dose fibrinogen concentrate. Diagnosis and treatment control were performed by thrombelastography.
Heindl
B
B
Klinik für Anaesthesiologie, Ludwig Maximilians Universität, München. Bernhard.Heindl@med.uni-muenchen.de
Delorenzo
C
C
Spannagl
M
M
D000368:Aged; D001778:Blood Coagulation Disorders / Q000188:drug therapy* / Q000209:etiology; D016063:Blood Loss, Surgical; D005340:Fibrinogen / Q000008:administration & dosage* / Q000627:therapeutic use*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007431:Intraoperative Complications / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000150:complications / Q000601:surgery; D013916:Thrombelastography; D065227:Transfusion Reaction
D005340:Fibrinogen