Evaluation of urinary PrPSc as a diagnostic test for sporadic, variant, and familial CJD.
Previously collected urine specimens from 100 patients referred to the UK National CJD Surveillance Unit as suspected cases of Creutzfeldt-Jakob disease (CJD) were analyzed, testing for abnormal prion protein (PrP(Sc)). In this context, the test had a low sensitivity and was not completely specific for CJD. Additionally, the proteins detected by this assay were not PrP(Sc) but appeared to be immunoglobulins.
Head
M W
MW
National CJD Surveillance Unit, School of Molecular and Clinical Medicine, University of Edinburgh, UK. m.w.head@ed.ac.uk
Kouverianou
E
E
Taylor
L
L
Green
A
A
Knight
R
R
D000918:Antibody Specificity / Q000276:immunology; D015153:Blotting, Western / Q000379:methods / Q000592:standards; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis* / Q000276:immunology / Q000652:urine*; D003429:Cross Reactions / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology / Q000652:urine*; D018620:PrPSc Proteins / Q000276:immunology / Q000652:urine*; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D016482:Urinalysis / Q000379:methods / Q000592:standards; D014556:Urine / Q000737:chemistry*
D007136:Immunoglobulins; D018620:PrPSc Proteins