Adrenomedullin: a new target for the design of small molecule modulators with promising pharmacological activities.
Adrenomedullin (AM) is a 52-amino acid peptide with a pluripotential activity. AM is expressed in many tissues throughout the body, and plays a critical role in several diseases such as cancer, diabetes, cardiovascular and renal disorders, among others. While AM is a protective agent against cardiovascular disorders, it behaves as a stimulating factor in other pathologies such as cancer and diabetes. Therefore, AM is a new and promising target for the development of molecules which, through their ability to regulate AM levels, could be used in the treatment of these pathologies.
Julián
Miguel
M
Departamento de Química, Facultad de Farmacia, Universidad San Pablo CEU, Urbanización Montepríncipe, 28668 Boadilla del Monte, Madrid, Spain. m.julian@ceu.es
Cacho
Mónica
M
García
Mario A
MA
Martín-Santamaría
Sonsoles
S
de Pascual-Teresa
Beatriz
B
Ramos
Ana
A
Martínez
Alfredo
A
Cuttitta
Frank
F
D053607:Adrenomedullin; D000595:Amino Acid Sequence; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D003920:Diabetes Mellitus / Q000188:drug therapy*; D015195:Drug Design; D006801:Humans; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000188:drug therapy*; D010455:Peptides / Q000187:drug effects* / Q000502:physiology; D016415:Sequence Alignment
D000959:Antihypertensive Agents; D010455:Peptides; D053607:Adrenomedullin