title: Nephrotic syndrome associated with administration of sulfadimethoxine/ormetoprim in a dobermann.
abstract: This case report describes sulphonamide-induced nephrotic syndrome in a young dobermann dog. The clinical signs and laboratory abnormalities resolved shortly after discontinuation of the sulphonamide antibiotic and with generalised supportive care. Since nephrotic syndrome typically carries a guarded prognosis in veterinary medicine and is poorly responsive to therapy, a thorough drug history should be an important part of the investigation of any animal with a protein-losing nephropathy.
authors.affiliation: Department of Clinical Sciences, Mississippi State University College of Veterinary Medicine, Starkville, Mississippi, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Vasilopulos
authors.forename: A
authors.initials: A
authors.lastname: Mackin
authors.forename: S N
authors.initials: SN
authors.lastname: Lavergne
authors.forename: L A
authors.initials: LA
authors.lastname: Trepanier
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004283:Dog Diseases / Q000139:chemically induced* / Q000628:therapy; D004285:Dogs; D004338:Drug Combinations; D008297:Male; D009404:Nephrotic Syndrome / Q000139:chemically induced / Q000628:therapy / Q000662:veterinary*; D011379:Prognosis; D011743:Pyrimidines / Q000009:adverse effects* / Q000627:therapeutic use; D013412:Sulfadimethoxine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D004338:Drug Combinations; D011743:Pyrimidines; D013412:Sulfadimethoxine; C100125:ormetoprim