title: Nodule detection in digital chest radiography: summary of the RADIUS chest trial.
abstract: As a part of the Europe-wide research project 'Unification of physical and clinical requirements for medical X-ray imaging'-governed by the Radiological Imaging Unification Strategies (RADIUS) Group-a major image quality trial was conducted by members of the group. The RADIUS chest trial aimed at thoroughly examining various aspects of nodule detection in digital chest radiography, such as the effects of nodule location, system noise, anatomical noise, and anatomical background. The main findings of the RADIUS chest trial concerning the detection of a lung nodule with a size in the order of 10 mm can be summarised as: (1) the detectability of the nodule is largely dependent on its location in the chest, (2) the system noise has a minor impact on the detectability at the dose levels used today, (3) the disturbance of the anatomical noise is larger than that of the system noise but smaller than that of the anatomical background and (4) the anatomical background acts as noise to a large extent and is the major image component affecting the detectability of the nodule.
authors.affiliation: Department of Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden. markus.hakansson@vgregion.se
authors.forename: Markus
authors.initials: M
authors.lastname: Håkansson
authors.forename: Magnus
authors.initials: M
authors.lastname: Båth
authors.forename: Sara
authors.initials: S
authors.lastname: Börjesson
authors.forename: Susanne
authors.initials: S
authors.lastname: Kheddache
authors.forename: Anna
authors.initials: A
authors.lastname: Grahn
authors.forename: Mark
authors.initials: M
authors.lastname: Ruschin
authors.forename: Anders
authors.initials: A
authors.lastname: Tingberg
authors.forename: Sören
authors.initials: S
authors.lastname: Mattsson
authors.forename: Lars Gunnar
authors.initials: LG
authors.lastname: Månsson
mesh_terms: D016477:Artifacts; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008168:Lung / Q000000981:diagnostic imaging* / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D008953:Models, Anatomic; D009010:Monte Carlo Method; D015588:Observer Variation; D012372:ROC Curve; D011856:Radiographic Image Enhancement / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D011859:Radiography / Q000379:methods*; D013902:Radiography, Thoracic / Q000379:methods*; D012542:Scattering, Radiation; D012984:Software; D014965:X-Rays