Opsonization effects on Mycobacterium avium subsp. paratuberculosis--macrophage interactions.
High antibody titers in ruminants infected with Mycobacterium avium subsp. paratuberculosis correlates with disease progression. Effects of humoral responses during mycobacterial infection are not completely understood. This study suggests that activation status may be an important factor in determining macrophage ability to limit proliferation of opsonized M. avium subsp. paratuberculosis.
Hostetter
J
J
Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA. jesseh@iastate.edu
Kagan
R
R
Steadham
E
E
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood*; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology* / Q000382:microbiology; D002478:Cells, Cultured; D015169:Colony Count, Microbial; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology* / Q000382:microbiology; D008856:Microscopy, Fluorescence; D009162:Mycobacterium avium / Q000254:growth & development / Q000276:immunology* / Q000472:pathogenicity; D014380:Tuberculosis, Bovine / Q000276:immunology*
D000907:Antibodies, Bacterial