title: New insight into the pathophysiology of severe hypothyroidism in an infant with multiple hepatic hemangiomas.
abstract: We report on an infant with severe acquired hypothyroidism resulting from both increased activity of type 3 iodothyronine deiodinase and increased production of TSH-like hormone from hepatic hemangiomas. The combination of these two mechanisms in a patient with hepatic hemangiomas has not been reported previously.
authors.affiliation: Department of Pediatrics, Alberta Children's Hospital, Calgary, Alberta, Canada.
authors.forename: Josephine
authors.initials: J
authors.lastname: Ho
authors.forename: Victoria
authors.initials: V
authors.lastname: Kendrick
authors.forename: Deborah
authors.initials: D
authors.lastname: Dewey
authors.forename: Danièle
authors.initials: D
authors.lastname: Pacaud
mesh_terms: D005260:Female; D006391:Hemangioma / Q000150:complications*; D006801:Humans; D007037:Hypothyroidism / Q000209:etiology* / Q000503:physiopathology*; D007223:Infant; D007231:Infant, Newborn; D008113:Liver Neoplasms / Q000150:complications*; D012720:Severity of Illness Index; D014284:Triiodothyronine / Q000378:metabolism
chemical_list: D014284:Triiodothyronine