Cytotoxic lignans from the stems of Styrax camporum (Styracaceae).
An ethanolic extract from the stems of Styrax camporum Pohl (Styracaceae), a plant traditionally used for gastrointestinal diseases, was fractionated and subjected to flash chromatography and afforded two benzofuran lignans, egonol and homoegonol, and one furofuran lignan, (+/-)syringaresinol, which were identified by spectral data interpretation. Their cytotoxic activities against Hep-2 (larynx epidermoid carcinoma), HeLa (human cervix carcinoma) and C6 (rat glioma) cell lines were evaluated using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) assay at several concentrations for 24h. Activities could be observed for egonol against C6 (IC50 = 3.2 microg/mL) and Hep-2 (IC50 = 3.6 microg/mL) cell lines, and for homoegonol against C6 (IC50 = 4.9 microg/mL) and HeLa (IC50 = 5.3 microg/mL) cells.
Teles
Helder L
HL
Instituto de Química - UNESP, Araraquara, C.P. 355, 14800-900.
Hemerly
Jefferson P
JP
Paulettit
Patrícia M
PM
Pandolfi
José R C
JR
Araujot
Angela R
AR
Valentini
Sandro R
SR
Young
M Claudia M
MC
Bolzani
Vanderlan S
VS
Silva
Dulce H S
DH
D000818:Animals; D000840:Anisoles / Q000737:chemistry* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D001572:Benzofurans / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D032362:Styrax / Q000737:chemistry*
D000840:Anisoles; D000972:Antineoplastic Agents, Phytogenic; D001572:Benzofurans; D017705:Lignans; C000597557:homoegonol