title: [Lung dysfunction in patients with severe chronic obstructive bronchitis].
abstract: VC, FVC, FEV1, FEV1/VC%, PEF, MEF25, MEF50, MEF75, TCL, TGV, RV, Raw, Rin, Rex, DLCO-SS, PaO2, and PaCO2 were determined in 36 patients with severe chronic obstructive lung disease (FEV1 < 50% of the normal value). All the patients were found to have impaired bronchial patency and changes in lung volumes and capacities; 83.3% of the patients had pulmonary gas exchange dysfunction. Impaired bronchial patency mainly appeared as decreased FEV1, FEV1/VC%, PEF, MEF25, MEF50, MEF75, Raw, Rin, Rex; altered lung volumes and capacities manifested by increased RV, TGV, and TLC, and by decreased VC and FVC; pulmonary gas exchange dysfunction showed up as lowered PaO2 and DLCO-SS, as decreased or increased PaCO2. The observed bronchial patency disorders varied from significant to severe; functional changes in lung volumes and capacities were mild to severe.
authors.forename: V B
authors.initials: VB
authors.lastname: Nefedov
authors.forename: L A
authors.initials: LA
authors.lastname: Popova
authors.forename: E A
authors.initials: EA
authors.lastname: Shergina
mesh_terms: D000328:Adult; D000368:Aged; D000402:Airway Obstruction / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology*; D001991:Bronchitis / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology*; D002908:Chronic Disease; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index