title: Synthetic approaches towards structurally diverse gamma-butyrolactone natural-product-like compounds.
abstract: Natural products containing a gamma-butyrolactone ring are abundant in nature; however, few general synthetic approaches to their stereoselective synthesis with broad structural variety are known. In this article, recent developments towards mono- and polycyclic gamma-butyrolactone natural products and analogs are discussed. A special focus is given to asymmetric methods applying transition metal or organocatalysts that allow not only the efficient introduction of a broad variety of functional groups but ideally also the flexible construction of various natural-product-like, polycyclic scaffolds from common precursors.
authors.affiliation: Institut für Organische Chemie, Universität Regensburg, Universitätsstr. 31, 93053 Regensburg, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Seitz
authors.forename: Oliver
authors.initials: O
authors.lastname: Reiser
mesh_terms: D015107:4-Butyrolactone / Q000138:chemical synthesis* / Q000737:chemistry; D001685:Biological Factors / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D015195:Drug Design; D015394:Molecular Structure
chemical_list: D001685:Biological Factors; D015107:4-Butyrolactone