A pilot study on the use of a perfluorohexyloctane/silicone oil solution as a heavier than water internal tamponade agent.
OBJECTIVE
To report a prospective two centred non-comparative interventional pilot study of a solution of perfluorohexyloctane and silicone oil (Densiron-68) as a heavier than water internal tamponade.


METHODS
42 consecutive patients were recruited. The indications include proliferative vitreoretinopathy, retinal detachments arising from inferior retinal breaks, and inability to posture.


RESULTS
The success rate with one operation using Densiron was 81% and with further surgery 93%. At the end of the study all tamponade agents were removed in 90% of patients. Visual acuity improved from mean logMAR of 1.41 (SD 0.64) to 0.94 (SD 0.57), p = 0.001. There was little evidence of dispersion and excessive inflammation.


CONCLUSIONS
This new tamponade agent is being compared to conventional silicone oil in a prospective international randomised trial.
Wong
D
D
St Paul's Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK. shdwong@liv.ac.uk
Van Meurs
J C
JC
Stappler
T
T
Groenewald
C
C
Pearce
I A
IA
McGalliard
J N
JN
Manousakis
E
E
Herbert
E N
EN
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004338:Drug Combinations; D005260:Female; D005466:Fluorocarbons / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000209:etiology; D010865:Pilot Projects; D011182:Postoperative Care / Q000379:methods; D011183:Postoperative Complications; D011187:Posture; D011446:Prospective Studies; D012008:Recurrence; D012163:Retinal Detachment / Q000503:physiopathology / Q000601:surgery*; D012827:Silicone Oils / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D013046:Specific Gravity; D016896:Treatment Outcome; D014792:Visual Acuity; D014821:Vitrectomy / Q000379:methods; D018630:Vitreoretinopathy, Proliferative / Q000503:physiopathology / Q000601:surgery
D004338:Drug Combinations; D005466:Fluorocarbons; D012827:Silicone Oils; C118616:perfluorohexyl-octan