title: Validation of simultaneous volumetric and spectrophotometric methods for the determination of captopril in pharmaceutical formulations.
abstract: Simple, sensitive and economical simultaneous volumetric and spectrophotometric methods for the determination of captopril have been developed. The methods were based on the reaction of captopril with potassium iodate in HCl medium. Amaranth was used as indicator to detect the end-point of the titration in aqueous layer. The iodine formed during the titration was extracted into CCl4 and subsequently determined spectrophotometrically at 510 nm. The Beer's law was obeyed in the concentration range of 120-520 microg ml-1. Rigorous statistical analyses were performed for the validation of the proposed methods. The proposed methods were successfully applied to the determination of captopril in dosage forms. Comparison of the means of the proposed procedures with those of reference methods using point and interval hypothesis tests showed no statistically significant difference.
authors.affiliation: Analytical Research Division, Department of Chemistry, Aligarh Muslim University, Aligarh 202 002, UP, India. cht17nr_amu@yahoo.com
authors.forename: Nafisur
authors.initials: N
authors.lastname: Rahman
authors.forename: Manisha
authors.initials: M
authors.lastname: Singh
authors.forename: Nasrul
authors.initials: N
authors.lastname: Hoda
mesh_terms: D002216:Captopril / Q000032:analysis* / Q000737:chemistry; D007452:Iodates / Q000737:chemistry; D017680:Potassium Compounds / Q000737:chemistry; D015203:Reproducibility of Results; D013053:Spectrophotometry / Q000379:methods; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods*; D017186:Titrimetry / Q000379:methods
chemical_list: D007452:Iodates; D017680:Potassium Compounds; D013607:Tablets; D002216:Captopril; C039693:potassium iodate