Secondary transitional cell carcinoma and nitrogen mustard treatment.
Transitional cell carcinoma (TCC) of the bladder in children is a rare occurrence. Cyclophosphamide is a known risk factor for the development of TCC. Other alkylating agents, such as nitrogen mustard, have not been implicated in the development of secondary adult or pediatric TCC. The role of radiotherapy in the development of secondary malignancies of the bladder remains controversial. We report a case of childhood TCC in a patient in remission from Hodgkin's lymphoma previously treated with non-cyclophosphamide chemotherapy and low-dose nodal radiotherapy.
DeLair
Sean M
SM
Department of Urology, University of California, Davis Children's Hospital, Sacramento, California 95608, USA.
White
Ralph W de Vere
RW
Kurzrock
Eric A
EA
D000293:Adolescent; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects* / Q000627:therapeutic use; D002295:Carcinoma, Transitional Cell / Q000139:chemically induced*; D006689:Hodgkin Disease / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D015182:Lymphatic Irradiation; D008297:Male; D008466:Mechlorethamine / Q000009:adverse effects* / Q000627:therapeutic use; D016609:Neoplasms, Second Primary / Q000139:chemically induced*; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced*
D018906:Antineoplastic Agents, Alkylating; D008466:Mechlorethamine