Microbial transformation of prednisone.
The microbial transformation of prednisone (17alpha,21-dihydroxy-pregna-1,4-diene-3,11,20-trione) (1) by Cunninghamella elegans afforded two metabolites, 17alpha,21-dihydroxy-5alpha-pregn-1-ene-3,11,20-trione (2) and 17alpha,20S,21-trihydroxy-5alpha-pregn-1-ene-3,11-dione (3), while the fermentation of 1 with Fusarium lini, Rhizopus stolonifer and Curvularia lunata afforded a metabolite 1,4-pregnadiene-17alpha,20S,21-triol-3,11-dione (4). Compound 3 was found to be a new metabolite. Their structures were elucidated on the basis of spectroscopic techniques. Compound 3 showed inhibitory activity against lipoxygenase enzyme.
Choudhary
M Iqbal
MI
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. hej@cyber.net.pk
Siddiqui
Zafar Ali
ZA
Musharraf
S Ghulam
SG
Nawaz
Sarfraz A
SA
Atta-Ur-Rahman
D001203:Ascomycota / Q000378:metabolism; D020093:Cunninghamella / Q000378:metabolism; D005285:Fermentation; D005658:Fungi / Q000378:metabolism*; D005670:Fusarium / Q000378:metabolism; D015394:Molecular Structure; D011241:Prednisone / Q000737:chemistry / Q000378:metabolism*; D012233:Rhizopus / Q000378:metabolism
D011241:Prednisone