Correlation between blood flow velocity in the middle cerebral artery and EEG during cognitive effort.
Cognitive effort modifies blood flow velocity (BFV) in the middle cerebral artery (MCA) which can be recorded by transcranial Doppler sonography (TCD). EEG parameters can be used as indicators of cortical activation. To find temporal and spatial relation between circulatory and bioelectric phenomena, we used combined EEG and TCD measurements during cognitive experiments. Bilateral BFV in the MCAs and 16-channel scalp EEG were recorded during mental arithmetic (MA) and verbal fluency (VF) tests in 12 healthy volunteers. Temporal profile of BFV, heart rate (HR), EEG central frequency (CF), relative alpha power (ralphap), and laterality index (Li) for BFV and CF were statistically analysed. During mental effort, BFV changes showed a reproducible pattern, which was different in MA and VF tests. The Li(BFV) correlated with handedness in 9/12 subjects (75%) in the VF, and in 6/12 subjects (50%) in the MA test. Significant correlation was found between Li(BFV) and Li(CF) during VF (r(2) = 0.69). Li was more indicative for the hemispheric dominance in the VF than in the MA test. During VF test, correlation between HR and BFV was significant in 7/12 subjects. CF and ralphap provide real time assessment of the functional state of the brain tissue during cognition. The correlation between CF and BFV during mental activity suggests a short latency neurogenic and a long latency, supposedly chemical regulation of regional blood flow. Parallel analysis of EEG and flow parameters increases the confidence of determining hemispheric dominance and provides an alternative to study physiological consequences of cognitive processes.
Szirmai
Imre
I
Department of Neurology, Semmelweis University Budapest, 1083 Budapest, Balassa u. 6. Hungary. szirmai@neur.sote.hu
Amrein
Ilona
I
Pálvölgyi
László
L
Debreczeni
Róbert
R
Kamondi
Anita
A
D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D004569:Electroencephalography; D005260:Female; D007839:Functional Laterality; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D020768:Middle Cerebral Artery / Q000502:physiology*; D009483:Neuropsychological Tests; D010775:Photic Stimulation / Q000379:methods; D013223:Statistics as Topic; D018709:Statistics, Nonparametric; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods; D014705:Verbal Behavior / Q000502:physiology