title: Fractionated stereotactic radiotherapy of optic pathway gliomas: tolerance and long-term outcome.
abstract: OBJECTIVE
  To evaluate the effectiveness and toxicity of fractionated stereotactically guided radiotherapy (FSRT) in the management of optic glioma.
  
  
  METHODS
  Fifteen patients with optic pathway gliomas were treated with FSRT at our institution between 1990 and 2003. A median target dose of 52.2 Gy (range, 45.2-57.6 Gy) was applied using a median fractionation of 5 fractions of 1.8 Gy weekly using a linear accelerator.
  
  
  RESULTS
  The median follow-up time was 97 months (range, 8-151 months). Of the 15 patients, 1 died of tumor progression during the follow-up period. The progression-free survival rate at 3 and 5 years was 92% and 72%, respectively. The median overall survival after FSRT was 90 months (range, 8-151 months). The 5-year survival rate after FSRT was 90%. We did not observe secondary malignancies.
  
  
  CONCLUSIONS
  Fractionated stereotactic radiotherapy was safe and well tolerated in all patients. The good tumor control and the potential of sparing normal brain tissue, especially the pituitary gland in lesions involving the optic chiasm, permit effective treatment of patients with optic nerve gliomas. Longer follow-up is needed to assess the incidence of late effects fully.
authors.affiliation: Department of Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Stephanie.Combs@med.uni-heidelberg.de
authors.forename: Stephanie E
authors.initials: SE
authors.lastname: Combs
authors.forename: Daniela
authors.initials: D
authors.lastname: Schulz-Ertner
authors.forename: Dimos
authors.initials: D
authors.lastname: Moschos
authors.forename: Christoph
authors.initials: C
authors.lastname: Thilmann
authors.forename: Peter E
authors.initials: PE
authors.lastname: Huber
authors.forename: Jürgen
authors.initials: J
authors.lastname: Debus
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D020339:Optic Nerve Glioma / Q000601:surgery*; D011836:Radiation Tolerance; D016634:Radiosurgery / Q000379:methods*; D013238:Stereotaxic Techniques