Achiral ligands dramatically enhance rate and enantioselectivity in the Rh/phosphoramidite-catalyzed hydrogenation of alpha,beta-disubstituted unsaturated acids.
Hoen
Rob
R
Department of Organic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Boogers
Jeroen A F
JA
Bernsmann
Heiko
H
Minnaard
Adriaan J
AJ
Meetsma
Auke
A
Tiemersma-Wegman
Theodora D
TD
de Vries
André H M
AH
de Vries
Johannes G
JG
Feringa
Ben L
BL
D000143:Acids / Q000737:chemistry*; D000179:Acrylates / Q000737:chemistry; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry*; D008024:Ligands; D008689:Methacrylates / Q000737:chemistry; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000737:chemistry*; D010666:Phenylpropionates / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
D000143:Acids; D000179:Acrylates; D008024:Ligands; D008689:Methacrylates; D009943:Organophosphorus Compounds; D010666:Phenylpropionates; C510582:alpha-methylcinnamic acid; C434331:phosphoramidite; D006859:Hydrogen; D012238:Rhodium; C036658:acrylic acid