Short stricture of the rectum regressing on discontinuation of hormone replacement therapy: endoscopic appearance, multiple biopsies and clinical improvement insufficient for diagnosis.
A short, benign-looking stricture of the rectum presented itself clinically as subileus in a middle-aged woman after 5 years on hormone replacement therapy (HRT) and 8 years after curative surgery for cancer of the ovaries. Radiological work-up and multiple, repeated biopsies supported the endoscopically appearing benign nature of the lesion, and the stricture subsided after discontinuation of HRT. Re-introduction of HRT again caused subileus. At surgery, there was no suspicion of malignant disease. Histological examination of the resection specimen did, however, show metastasis from the ovarian cancer.
Hoff
Geir
G
Telemark Hospital, Skien, Norway. hofg@online.no
Wiig
Johan
J
Reed
Wenche
W
Hole
Knut Håkon
KH
Scheistrøen
Marit
M
Henriksen
Halvor
H
D000328:Adult; D001706:Biopsy; D003113:Colonoscopy; D003251:Constriction, Pathologic; D003937:Diagnosis, Differential; D004958:Estradiol / Q000009:adverse effects*; D005260:Female; D020249:Hormone Replacement Therapy / Q000009:adverse effects*; D006801:Humans; D008279:Magnetic Resonance Imaging; D012002:Rectal Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed
D004958:Estradiol