title: Tyrosinase inhibition studies of diterpenoid alkaloids and their derivatives: structure-activity relationships.
abstract: In the present article, tyrosinase inhibition studies on fifteen diterpenoid alkaloids, with lycoctonine skeleton, and their semisynthetic derivatives 1-15 and six napelline-type compounds 16-21 are discussed. Their structure-activity relationship for tyrosinase inhibition is also discussed. These activities were compared with two referenced tyrosinase inhibitors, kojic acid and L-mimosine. The study showed that lappaconitine HBr (1) is the most potent member of the series (IC50 = 13.30 microM).
authors.affiliation: S. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences Republic of Uzbekistan, Tashkent, Uzbekistan.
authors.forename: Mukhlis N
authors.initials: MN
authors.lastname: Sultankhodzhaev
authors.forename: Mahmud Tareq Hassan
authors.initials: MT
authors.lastname: Khan
authors.forename: Mahera
authors.initials: M
authors.lastname: Moin
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.lastname: Atta-ur-Rahman
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D000470:Alkaloids; D004224:Diterpenes; D014442:Monophenol Monooxygenase