title: [Primary amebic meningoencephalitis: 1st case observed in Madagascar].
abstract: The primary amebic meningoencephalitis is an acute suppurative infection that involves both the brain and the meninges. It is caused by Naegleria fowleri and is a very rare and fulminating condition, so far nearly always fatal. We report the first case in the area of Southern part of Indian Ocean that occured in a 7-year old French boy living in Madagascar. It is assumed that the disease was contracted by swimming in warm fresh water in a lake of the Madagascar east coast. Clinical signs began 10-12 days after exposure, associating headache, vomiting and pyrexia (39-40 degrees C). Upon admission in a Madagascar hospital, the patient was started on antibiotics, that did not control the disease and soon presented with a loss of consciousness and a delirium. He was transferred to Reunion island (Centre Hospitalier Départemental Félix-Guyon), where the diagnosis of primary amebic meningoencephalitis was confirmed. Therefore, he was started on high-dose of intraspinal amphotericin B, IV amphotericin B lipid complex and tetracycline. He developed myocarditis, diabetes insipidus, deep coma and subsequently died a week later. The diagnosis of amebic meningoencephalitis was based on: -- the cerebrospinal fluid examination that confirmed the diagnosis of purulent meningitis: 420 leucocytes (76% polynuclears, 14% lymphocytes), 90 red blood cells, and showed 50 ameboid trophozoites per 100 leucocytes, approximately 20 microm in size. -- the flagellate transformation test in distilled water showed two anterior flagellas that confirmed the genus Naegleria.
authors.affiliation: Laboratoire de biologie, Centre hospitalier départemental Félix-Guyon Saint-Denis, La Réunion, France. mcjaffar@chd-fguyon.fr
authors.forename: M C
authors.initials: MC
authors.lastname: Jaffar-Bandjee
authors.forename: J L
authors.initials: JL
authors.lastname: Alessandri
authors.forename: B
authors.initials: B
authors.lastname: Molet
authors.forename: J
authors.initials: J
authors.lastname: Clouzeau
authors.forename: L
authors.initials: L
authors.lastname: Jacquemot
authors.forename: S
authors.initials: S
authors.lastname: Sampériz
authors.forename: J C
authors.initials: JC
authors.lastname: Saly
mesh_terms: D000562:Amebiasis / Q000175:diagnosis; D000818:Animals; D002648:Child; D017809:Fatal Outcome; D006801:Humans; D008270:Madagascar; D008297:Male; D008590:Meningoencephalitis / Q000175:diagnosis / Q000469:parasitology*; D016848:Naegleria fowleri