title: Lack of association between polymorphism of the human cyclic GMP-dependent protein kinase gene and obesity.
abstract: OBJECTIVE
  To investigate whether genetic variation in the cyclic GMP-dependent protein kinase gene (PRKG1) is associated with obesity.
  
  
  METHODS
  The study included 143 individuals from New York City area, NY, USA. The subjects were sampled on the basis of body mass index (BMI): obese (BMI ranging from 33.8 to 89.5 kg/m(2)), and nonobese (BMI ranging from 16.0 to 29.4 kg/m(2)). The association between C2276T polymorphism in PRKG1 gene and obesity was tested using linear regression analysis.
  
  
  RESULTS
  BMI levels were predicted by linear regression models adjusted for demographic factors. An analysis was performed twice: in individuals of all ethnic backgrounds and in European-Americans only. In both cases, genotype did not have a significant effect.
  
  
  CONCLUSIONS
  We found no evidence that the C2276T polymorphism in the PKRG1 gene is associated with obesity.
authors.affiliation: Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
authors.forename: S O
authors.initials: SO
authors.lastname: Zakharkin
authors.forename: A T
authors.initials: AT
authors.lastname: Belay
authors.forename: J R
authors.initials: JR
authors.lastname: Fernandez
authors.forename: V
authors.initials: V
authors.lastname: De Luca
authors.forename: J L
authors.initials: JL
authors.lastname: Kennedy
authors.forename: M B
authors.initials: MB
authors.lastname: Sokolowski
authors.forename: D B
authors.initials: DB
authors.lastname: Allison
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D017869:Cyclic GMP-Dependent Protein Kinases / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000201:enzymology / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic
chemical_list: D017869:Cyclic GMP-Dependent Protein Kinases