Aryl hydrocarbon exposure induces expression of MMP-9 in human prostate cancer cell lines.
Although aromatic hydrocarbons have been extensively studied with regard to tumor formation, there has been little investigation into effects of these environmental chemicals on regulation of genes involved in tumor invasion. We investigated effects of three arylhydrocarbons on expression of MMP-9 in PC-3 and DU145 human prostate cancer cells. TCDD exposure lead to dose and time dependent increases in MMP-9 expression. Benzo(a)pyrene and a PAH-containing soot (BDS) also induced this MMP. These hydrocarbons also stimulated MMP-9 protein secretion. Our data demonstrate that aryl hydrocarbons can stimulate the production of MMP-9 in human prostate cancer cells.
Haque
Masudul
M
Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.
Francis
Joseph
J
Sehgal
Inder
I
D001564:Benzo(a)pyrene / Q000494:pharmacology*; D002244:Carbon; D002471:Cell Transformation, Neoplastic; D004785:Environmental Pollutants / Q000494:pharmacology*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis*; D000072317:Polychlorinated Dibenzodioxins / Q000494:pharmacology*; D011084:Polycyclic Aromatic Hydrocarbons / Q000494:pharmacology; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology*; D014407:Tumor Cells, Cultured
D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins; D011084:Polycyclic Aromatic Hydrocarbons; D001564:Benzo(a)pyrene; D002244:Carbon; D020780:Matrix Metalloproteinase 9