title: Trading places: how do DNA polymerases switch during translesion DNA synthesis?
abstract: The replicative bypass of base damage in DNA (translesion DNA synthesis [TLS]) is a ubiquitous mechanism for relieving arrested DNA replication. The process requires multiple polymerase switching events during which the high-fidelity DNA polymerase in the replication machinery arrested at the primer terminus is replaced by one or more polymerases that are specialized for TLS. When replicative bypass is fully completed, the primer terminus is once again occupied by high-fidelity polymerases in the replicative machinery. This review addresses recent advances in our understanding of DNA polymerase switching during TLS in bacteria such as E. coli and in lower and higher eukaryotes.
authors.affiliation: Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. friedberg.errol@pathology.swmed.edu
authors.forename: Errol C
authors.initials: EC
authors.lastname: Friedberg
authors.forename: Alan R
authors.initials: AR
authors.lastname: Lehmann
authors.forename: Robert P P
authors.initials: RP
authors.lastname: Fuchs
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D004247:DNA / Q000378:metabolism / Q000528:radiation effects; D004249:DNA Damage; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008957:Models, Genetic; D009687:Nuclear Proteins; D009713:Nucleotidyltransferases / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D000099270:Y-Family DNA Polymerases
chemical_list: D001426:Bacterial Proteins; D004247:DNA; D004259:DNA-Directed DNA Polymerase; D009687:Nuclear Proteins; D009713:Nucleotidyltransferases; C429004:REV1 protein, human; D000099270:Y-Family DNA Polymerases