Black cohosh: just another phytoestrogen?
Most clinical trials on phytoestrogens detected no significant effects on classic menopausal symptoms. Soy-rich diets positively influence certain aspects (e.g. sleep disturbances and mood swings), but the level of relief is low. Duration of the specific diet before menopause onset predicts the extent of the benefit. Isoflavones exert competitive effects at the estrogen receptor and might interfere with anti-proliferative properties of endocrine anti-cancer therapies. Clinical trials on effects of Actaea racemosa (black cohosh) extracts on menopausal symptoms have yielded more positive results. Two recent studies showed excellent efficacy against classic menopausal complaints and osteoprotective properties, and extracts were deemed safe even when the dosage was increased threefold. Furthermore, several studies suggest that A. racemosa extracts might help control psychic problems typically found during menopausal transition.
Viereck
Volker
V
Department of Obstetrics and Gynecology, Georg-August-University of Göttingen, Robert-Koch-Strasse 40, D-37075 Göttingen, Germany.
Emons
Günter
G
Wuttke
Wolfgang
W
D001842:Bone and Bones / Q000187:drug effects; D031885:Cimicifuga / Q000737:chemistry*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008593:Menopause / Q000187:drug effects; D008875:Middle Aged; D048789:Phytoestrogens / Q000737:chemistry / Q000494:pharmacology*; D017698:Postmenopause / Q000187:drug effects
D048789:Phytoestrogens