title: Soluble adhesion molecules and marine n-3 fatty acids in patients referred for coronary angiography.
abstract: OBJECTIVE
  To investigate the relationship between soluble cellular adhesion molecules (sCAMs) and the extent of coronary artery disease (CAD) in patients with stable angina pectoris.
  
  
  RESULTS
  Two hundred and ninety-one subjects had fasting levels of circulating intercellular adhesion molecule-1(sICAM-1), vascular cellular adhesion molecule-1 (sVCAM-1), sP-selectin and contents of n-3 polyunsaturated fatty acids (n-3 PUFA) in granulocyte membranes and adipose tissue determined before undergoing elective coronary angiography. Levels of soluble VCAM-1 (983+/-216 versus 893+/-196 ng/l, p<0.001), ICAM-1 (318+/-140 versus 290+/-75 ng/l, p<0.05) and P-selectin (90+/-27 versus 80+/-23 ng/l, p<0.01) were significantly increased in subjects with significant CAD compared to subjects with no significant stenoses. In a linear regression analysis, both sVCAM-1 and sP-selectin, but not sICAM-1, correlated to the presence and the severity of CAD. Both sICAM-1 and sP-selectin were significantly correlated to current smoking status and a history of myocardial infarction. The content of total n-3 PUFA and docosahexaenoic acid in adipose tissue was marginally, but significant positively correlated to VCAM-1.
  
  
  CONCLUSIONS
  sVCAM-1 and sP-selectin may serve as markers of CAD in patients with stable angina pectoris. Only sVCAM-1 was weakly correlated to n-3 PUFA in adipose tissue.
authors.affiliation: Center for Cardiovascular Research, Department of Cardiology, Aalborg Sygehus, Aarhus University Hospital, Aalborg, Denmark. oe@dadlnet.dk
authors.forename: Ole
authors.initials: O
authors.lastname: Eschen
authors.forename: Jeppe Hagstrup
authors.initials: JH
authors.lastname: Christensen
authors.forename: Egon
authors.initials: E
authors.lastname: Toft
authors.forename: Erik Berg
authors.initials: EB
authors.lastname: Schmidt
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry; D000787:Angina Pectoris / Q000503:physiopathology*; D015415:Biomarkers / Q000032:analysis*; D015331:Cohort Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000473:pathology*; D005227:Fatty Acids / Q000032:analysis*; D005260:Female; D005395:Fish Oils; D006098:Granulocytes; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000032:analysis*; D012720:Severity of Illness Index; D019010:Vascular Cell Adhesion Molecule-1 / Q000032:analysis*
chemical_list: D015415:Biomarkers; D005227:Fatty Acids; D005395:Fish Oils; D019007:P-Selectin; D019010:Vascular Cell Adhesion Molecule-1