title: Behaviour and design considerations for continuous flow closed-open-closed liquid microchannels.
abstract: This paper introduces a method of combining open and closed microchannels in a single component in a novel way which couples the benefits of both open and closed microfluidic systems and introduces interesting on-chip microfluidic behaviour. Fluid behaviour in such a component, based on continuous pressure driven flow and surface tension, is discussed in terms of cross sectional flow behaviour, robustness, flow-pressure performance, and its application to microfluidic interfacing. The closed-open-closed microchannel possesses the versatility of upstream and downstream closed microfluidics along with open fluidic direct access. The device has the advantage of eliminating gas bubbles present upstream when these enter the open channel section. The unique behaviour of this device opens the door to applications including direct liquid sample interfacing without the need for additional and bulky sample tubing.
authors.affiliation: Royal Institute of Technology, Department of Signals, Sensors and Systems, Microsystem Technology, Osquldas vag 10, SE 100 44 Stockholm, Sweden.
authors.forename: Jessica
authors.initials: J
authors.lastname: Melin
authors.forename: Wouter
authors.initials: W
authors.lastname: van der Wijngaart
authors.forename: Göran
authors.initials: G
authors.lastname: Stemme
mesh_terms: D004867:Equipment Design; D044085:Microfluidics / Q000295:instrumentation* / Q000379:methods*; D011312:Pressure; D012680:Sensitivity and Specificity; D013499:Surface Properties