[Effect of diltiazem on cholesterol and phospholipid content and intensity of free radical oxidation process in plasma membranes of cardiomyocytes and blood cells in experimental hypercholesterolemia].
Changes of lipid structure and function in membranes of cardiomyocytes and blood cells of rabbits were investigated under the effect of experimental hypercholesterolemia and calcium antagonist diltiazem influence. The activity of peroxide oxidizing of lipids (POL) and protein in membrane of sarcolemma, blood cells and serum, and activity of the same enzymes of antioxidant system--catalase (CAT) and superoxide dismutase (SOD) were studied as well. The research marks that diltiazem was manifested by activation of antioxidant system in cardiomyocytes and membrane sarcolemma, normalization of its lipid structure and by the decrease of the content of products POL and oxidizing of protein.
Vasilinchuk
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D000818:Animals; D001773:Blood Cells / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D004110:Diltiazem / Q000494:pharmacology*; D004195:Disease Models, Animal; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D005609:Free Radicals / Q000378:metabolism; D006937:Hypercholesterolemia / Q000097:blood / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008563:Membrane Lipids / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D010743:Phospholipids / Q000378:metabolism; D011817:Rabbits
D002121:Calcium Channel Blockers; D005609:Free Radicals; D008563:Membrane Lipids; D010743:Phospholipids; D002784:Cholesterol; D004110:Diltiazem