title: 7-amino-3,5-dimethylisoxazole [5,4-e] [1,3,4]-triazepin-4-one- a potential new lead structure: its structure, physicochemical properties and biological activity.
abstract: Structural and biological investigations on a new 7-amino-3,5-dimethylisoxazole [5,4e][1,3,4]-triazepin-4-one were performed. The compound was shown to stimulate concanavalin A-induced mouse splenocyte proliferation and cytokine production by macrophage P388D1 cell line.
authors.affiliation: Wrocław Medical University, Faculty of Pharmacy, Department of Organic Chemistry, 9 Grodzka Str., 50-137 Wrocław, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Drozd-Szczygieł
authors.forename: Stanisław
authors.initials: S
authors.lastname: Ryng
authors.forename: Michał
authors.initials: M
authors.lastname: Zimecki
mesh_terms: D000818:Animals; D001381:Azepines / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D016207:Cytokines / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D007202:Indicators and Reagents; D007555:Isoxazoles / Q000138:chemical synthesis*; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000166:cytology / Q000187:drug effects
chemical_list: C501454:7-amino-3,5-dimethylisoxazole (5,4-e) (1,3,4)-triazepin-4-one; D001381:Azepines; D016207:Cytokines; D007202:Indicators and Reagents; D007555:Isoxazoles; D008070:Lipopolysaccharides