title: The effect of the CC chemokine receptor antagonist Met-RANTES on experimental autoimmune uveitis and oral tolerance.
abstract: Lymphocyte trafficking is controlled in part by the actions of chemokines. In rat experimental autoimmune uveitis (EAU) we observed differential therapeutic effects of Met-RANTES, a CCR1/CCR5 receptor antagonist, depending on the retinal antigen peptides inducing the disease and the time of application during the afferent or efferent immune response. CCR1 and/or CCR5 blockade may have inhibitory effects on different phases of the autoimmune response, depending on the antigen specificity of T cells in EAU. In contrast, Met-RANTES enhanced therapeutic oral tolerance independently of orally applied antigen.
authors.affiliation: Section of Immunobiology, Department of Ophthalmology, Ludwig-Maximilians-University, Mathildenstr. 8, 80336 Munich, Germany. Maria.Diedrichs-Moehring@med.uni-muenchen.de
authors.forename: Maria
authors.initials: M
authors.lastname: Diedrichs-Möhring
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Nelson
authors.forename: Amanda E I
authors.initials: AE
authors.lastname: Proudfoot
authors.forename: Stephan R
authors.initials: SR
authors.lastname: Thurau
authors.forename: Gerhild
authors.initials: G
authors.lastname: Wildner
mesh_terms: D000818:Animals; D019393:Arrestin / Q000737:chemistry / Q000633:toxicity; D001327:Autoimmune Diseases / Q000139:chemically induced / Q000188:drug therapy*; D018946:Chemokine CCL5 / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D019742:Chemokines, CC / Q000037:antagonists & inhibitors*; D016207:Cytokines / Q000378:metabolism; D004347:Drug Interactions; D053331:Ectodysplasins; D005123:Eye / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D005136:Eye Proteins / Q000737:chemistry / Q000633:toxicity; D007150:Immunohistochemistry / Q000379:methods; D008565:Membrane Proteins / Q000378:metabolism; D010455:Peptides / Q000633:toxicity; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D011917:Rats, Inbred Lew; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000378:metabolism; D012177:Retinol-Binding Proteins / Q000737:chemistry / Q000633:toxicity; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D012720:Severity of Illness Index; D013601:T-Lymphocytes / Q000187:drug effects; D013997:Time Factors; D014605:Uveitis / Q000139:chemically induced / Q000188:drug therapy*; D014611:Vaccination / Q000379:methods; D000099214:Retinol-Binding Proteins, Interstitial
chemical_list: D019393:Arrestin; D018946:Chemokine CCL5; D019742:Chemokines, CC; D016207:Cytokines; D053331:Ectodysplasins; D005136:Eye Proteins; D008565:Membrane Proteins; D010455:Peptides; D012333:RNA, Messenger; D016693:Receptors, Antigen, T-Cell, alpha-beta; D012177:Retinol-Binding Proteins; D000099214:Retinol-Binding Proteins, Interstitial; C108335:RANTES, Met-