title: Structural investigations of pyridin-4-yl indolizine modified beta-cyclodextrin derivatives as fluorescent chemosensors for organic guest molecules.
abstract: In order to investigate the substituent effects on their conformations and spectroscopic properties, a series of pyridin-4-ylindolizine modified beta-cyclodextrin derivatives were studied by 2D NMR (ROESY spectra) in D2O, circular dichroïsm, and fluorescence spectroscopy. It was found that the linked indolizin-beta-cyclodextrin compounds exhibited two types of conformations, as a function of the substituent, in which fluorescent moieties formed either an intramolecular complex or were not included in the hydrophobic cavity of the macrocycle. Under addition of organic guest species in a phosphate buffer at neutral pH, the variation of emission fluorescence intensity showed that these compounds are of significance for detection of volatile organic molecules and adamantane derivatives and might be used as molecular chemosensor.
authors.affiliation: Laboratoire de Synthèse Organique et Environnement, Université du Littoral Côte d'Opale, 145 avenue M. Schumann, F-59140 Dunkerque, France. delattre@univ-littoral.fr
authors.forename: François
authors.initials: F
authors.lastname: Delattre
authors.forename: Patrice
authors.initials: P
authors.lastname: Woisel
authors.forename: Marc
authors.initials: M
authors.lastname: Bria
authors.forename: Gheorghe
authors.initials: G
authors.lastname: Surpateanu
mesh_terms: D002942:Circular Dichroism; D005453:Fluorescence; D006863:Hydrogen-Ion Concentration; D007212:Indolizines / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013696:Temperature; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D007212:Indolizines; D011725:Pyridines; D047392:beta-Cyclodextrins