title: Development of a practical image-based scatter correction method for brain perfusion SPECT: comparison with the TEW method.
abstract: OBJECTIVE
  An image-based scatter correction (IBSC) method was developed to convert scatter-uncorrected into scatter-corrected SPECT images. The purpose of this study was to validate this method by means of phantom simulations and human studies with 99mTc-labeled tracers, based on comparison with the conventional triple energy window (TEW) method.
  
  
  METHODS
  The IBSC method corrects scatter on the reconstructed image I(mub)AC with Chang's attenuation correction factor. The scatter component image is estimated by convolving I(mub)AC with a scatter function followed by multiplication with an image-based scatter fraction function. The IBSC method was evaluated with Monte Carlo simulations and 99mTc-ethyl cysteinate dimer SPECT human brain perfusion studies obtained from five volunteers. The image counts and contrast of the scatter-corrected images obtained by the IBSC and TEW methods were compared.
  
  
  RESULTS
  Using data obtained from the simulations, the image counts and contrast of the scatter-corrected images obtained by the IBSC and TEW methods were found to be nearly identical for both gray and white matter. In human brain images, no significant differences in image contrast were observed between the IBSC and TEW methods.
  
  
  CONCLUSIONS
  The IBSC method is a simple scatter correction technique feasible for use in clinical routine.
authors.affiliation: Department of Brain Science and Molecular Imaging, National Center for Geriatrics and Gerontology Research Institute, 36-3, Gengo Morioka-cho, Obu, Aichi, 474-8522, Japan. sidahara@nils.go.jp
authors.forename: Miho
authors.initials: M
authors.lastname: Shidahara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Watabe
authors.forename: Kyeong Min
authors.initials: KM
authors.lastname: Kim
authors.forename: Takashi
authors.initials: T
authors.lastname: Kato
authors.forename: Shoji
authors.initials: S
authors.lastname: Kawatsu
authors.forename: Rikio
authors.initials: R
authors.lastname: Kato
authors.forename: Kumiko
authors.initials: K
authors.lastname: Yoshimura
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Iida
authors.forename: Kengo
authors.initials: K
authors.lastname: Ito
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation / Q000379:methods*