[Intraperitoneal placement of composite implants--polyester mesh coated with polyurethane in experimental study].
BACKGROUND
Polyester and polypropylene are currently the most frequently materials for repair of abdominal wall hernias. Most of the mesh materials used intraperitoneally in repair of hernias lead to considerable adhesion formation, as well as the resultant bowel obstruction and intestinal fistula formation. Some newer composite products can reduce risk of adhesion formation. The aim of this experimental study is testing properties of patch, composite structure, characterised by the association of a non-woven textile structure made from polyester multifilaments, and a fine coat of polyurethane on one side, placed intraperitoneally in rat.


METHODS
The experiment was carried out with 21 laboratory rats. Laboratory animals were divided into 3 groups - 7 animals in a group. In the first group the check-up laparotomy was realized the 7th day, in the second group the 14th day and in the third group the 28th day after the intraperitoneal implantation of a composite mesh. All animals were sacrificed and adhesion scoring and histological evaluation of tissue specimens with implanted mesh were done.


RESULTS
A macroporous polyester mesh component supported an early and huge fibrous proliferation with a good adhesion onto the abdomen wall. On the other hand, a microporous polyurethane layer led to the creation of a fibrous pocket. During the check-up laparotomy, the larger adhesion of omentum to the fibrous layer, covering the polyurethane side of implanted mesh, were located in most laboratory rats - in all the groups.


CONCLUSIONS
We can presume that the protective polyurethane layer does not eliminate risk of adhesion formation in rat.
Chobola
M
M
Chirurgická klinika FN a LF UK, Hradec Králové. chobolam@lfhk.cuni.cz
Voboril
Z
Z
Hadzi
Nikolov D
ND
D000818:Animals; D020099:Coated Materials, Biocompatible; D020007:Implants, Experimental; D008297:Male; D010529:Peritoneal Cavity / Q000473:pathology / Q000601:surgery; D011091:Polyesters; D011140:Polyurethanes; D051381:Rats; D017208:Rats, Wistar; D013526:Surgical Mesh; D000267:Tissue Adhesions
D020099:Coated Materials, Biocompatible; D011091:Polyesters; D011140:Polyurethanes