title: Drug-induced QT interval prolongation after ciprofloxacin administration in a patient receiving olanzapine.
abstract: Several non-antiarrhythmic drugs including antibiotic and antipsychotic agents have been shown to prolong cardiac repolarization predisposing to torsade de pointes ventricular tachycardia. Blockade of the delayed rectifier (repolarising) potassium current and drug interactions with inhibitors of the CYP-mediated metabolism are the most common underlying mechanisms. In the present case report, an elderly woman receiving a long-term medication with azathioprine, olanzapine and valsartan developed a marked QT interval prolongation after intravenous administration of ciprofloxacin.
authors.forename: Konstantinos P
authors.initials: KP
authors.lastname: Letsas
authors.forename: Antonios
authors.initials: A
authors.lastname: Sideris
authors.forename: Stavros P
authors.initials: SP
authors.lastname: Kounas
authors.forename: Michalis
authors.initials: M
authors.lastname: Efremidis
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Korantzopoulos
authors.forename: Fotios
authors.initials: F
authors.lastname: Kardaras
mesh_terms: D000368:Aged; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000009:adverse effects*; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001569:Benzodiazepines / Q000009:adverse effects; D002037:Bundle-Branch Block / Q000139:chemically induced; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000009:adverse effects*; D004357:Drug Synergism; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced*; D000077152:Olanzapine
chemical_list: D000890:Anti-Infective Agents; D014150:Antipsychotic Agents; D001569:Benzodiazepines; D002939:Ciprofloxacin; D000077152:Olanzapine