title: Issues in the epidemiological investigation of dry mouth.
abstract: Despite decades of research, much remains unanswered about the epidemiology of dry mouth. This review aims to provide an overview of the condition's epidemiology and the issues to consider when planning an epidemiological study of dry mouth. The latter can be broadly grouped into: study design; sampling and statistical power considerations; the measurement of dry mouth; and the selection, nature and measurement of relevant exposure measures, including medications and potential confounding variables. Each of these is discussed, in order to provide guidance for prospective researchers based on experience with past research. Finally, an agenda for further epidemiological research into dry mouth is proposed.
authors.affiliation: Department of Oral Sciences, School of Dentistry, The University of Otago, Dunedin, New Zealand. murray.thomson@stonebow.otago.ac.nz
authors.forename: W Murray
authors.initials: WM
authors.lastname: Thomson
mesh_terms: D000368:Aged; D015986:Confounding Factors, Epidemiologic; D003627:Data Interpretation, Statistical; D003753:Dental Health Surveys; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D015995:Prevalence; D012107:Research Design; D012307:Risk Factors; D012463:Saliva / Q000378:metabolism; D012494:Sampling Studies; D012636:Secretory Rate; D014987:Xerostomia / Q000139:chemically induced / Q000175:diagnosis / Q000453:epidemiology*