Carbanion-mediated photocages: rapid and efficient photorelease with aqueous compatibility.
A new photocage is proposed, based on ketoprofen-derived compounds and mediated by carbanions. The new photocage has significant advantages over the widely used o-nitrobenzyl derivatives, including aqueous compatibility, faster photorelease, higher quantum yield, and innocuous byproducts. The photorelease of ibuprofen illustrates the properties of the new photocage.
Lukeman
Matthew
M
Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario K1N 6N5, Canada.
Scaiano
Juan C
JC
D001577:Benzophenones / Q000737:chemistry*; D007660:Ketoprofen / Q000031:analogs & derivatives* / Q000737:chemistry; D010777:Photochemistry; D014867:Water / Q000737:chemistry
D001577:Benzophenones; D014867:Water; D007660:Ketoprofen