Chromenes from the brown alga Sargassum siliquastrum.
Sargachromanols A-P (1-16), sixteen new meroterpenoids of the chromene class, were isolated from the brown alga Sargassum siliquastrum collected from Jaeju Island, Korea. On the basis of the combined results of spectral and chemical analyses, the structures of the polyprenyl portions of these chromanol-containing compounds were determined to be linear triprenyls (1 and 2) and tetraprenyls (3-11), while others were the corresponding rearranged (12-15) and cyclized (16) tetraprenyls, respectively. The new compounds exhibited significant antioxidant activity in the DPPH assay. Compounds 7 and 15 also showed inhibitory activity toward butylcholine esterase.
Jang
Kyoung Hwa
KH
Natural Products Research Institute, College of Pharmacy, Seoul National University, #28 Yungun, Jongro, Seoul 110-460, Korea.
Lee
Bong Ho
BH
Choi
Byoung Wook
BW
Lee
Hyi-Seung
HS
Shin
Jongheon
J
D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001713:Biphenyl Compounds; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007723:Korea; D015394:Molecular Structure; D000459:Phaeophyceae / Q000737:chemistry*; D010851:Picrates / Q000494:pharmacology; D013729:Terpenes / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification* / Q000494:pharmacology
D000975:Antioxidants; D001578:Benzopyrans; D001713:Biphenyl Compounds; D002800:Cholinesterase Inhibitors; D010851:Picrates; D013729:Terpenes; C004931:1,1-diphenyl-2-picrylhydrazyl