Collagenase inhibitory quinic acid esters from Ipomoea pes-caprae.
Two new quinic acid esters (1 and 2) were isolated from the extract of Ipomoea pes-caprae together with six known quinic acid esters (3-8). The structures of compounds 1 and 2 were elucidated by spectroscopic data interpretation. These new compounds exhibited collagenase inhibitory activity and showed almost no cytotoxicity.
Teramachi
Fumihiro
F
Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
Koyano
Takashi
T
Kowithayakorn
Thaworn
T
Hayashi
Masahiko
M
Komiyama
Kanki
K
Ishibashi
Masami
M
D000595:Amino Acid Sequence; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004952:Esters; D027741:Ipomoea / Q000737:chemistry*; D061965:Matrix Metalloproteinase Inhibitors; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011801:Quinic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013785:Thailand
C501808:3,5-di-O-caffeoyl-4-O-coumaroylquinic acid; C501809:4,5-di-O-caffeoyl-1,3-di-O-coumaroylquinic acid; D004791:Enzyme Inhibitors; D004952:Esters; D061965:Matrix Metalloproteinase Inhibitors; D011801:Quinic Acid