Suppression of laser-induced choroidal neovascularization by posterior sub-tenon administration of triamcinolone acetonide.
OBJECTIVE
To evaluate the inhibitory effect of triamcinolone acetonide (TA) on choroidal neovascularization (CNV) by posterior sub-Tenon administration using a laser-induced CNV model in the rat.


METHODS
Experimental CNV was induced by laser photocoagulation in Brown-Norway male rats. Experimental eyes received posterior sub-Tenon administration of either 2 mg (n = 10) or 0.5 mg (n = 8) of TA. Control eyes (n = 10) received posterior sub-Tenon administration of isotonic sodium chloride solution. Two weeks after treatment, CNV was evaluated by fluorescein angiography and histopathological examination. Concentrations of TA in the vitreous, retina, and choroid were determined by high-performance liquid chromatography at 3 and 7 days after posterior sub-Tenon administration.


RESULTS
The eyes treated with 2 mg of TA showed statistically significant inhibition of fluorescein leakage by fluorescein angiography, as compared with control eyes and eyes treated with 0.5 mg of TA (P < 0.01). The thickness of CNV membranes in eyes treated with 2 mg of TA also decreased statistically significantly, as compared with control eyes (P < 0.01). TA was detected in the vitreous, retina, and choroid 3 days after administration and in the choroid 7 days after administration.


CONCLUSIONS
Posterior sub-Tenon administration of TA may be useful to treat CNV.
Kato
Aki
A
Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Kimura
Hideya
H
Okabe
Komei
K
Okabe
Junko
J
Kunou
Noriyuki
N
Nozaki
Miho
M
Ogura
Yuichiro
Y
D000818:Animals; D002199:Capillary Permeability; D020256:Choroidal Neovascularization / Q000188:drug therapy* / Q000209:etiology; D002851:Chromatography, High Pressure Liquid; D003238:Connective Tissue / Q000187:drug effects*; D004195:Disease Models, Animal; D005451:Fluorescein Angiography; D005938:Glucocorticoids / Q000008:administration & dosage*; D017075:Laser Coagulation / Q000009:adverse effects; D008297:Male; D051381:Rats; D011914:Rats, Inbred BN; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*
D005938:Glucocorticoids; D014222:Triamcinolone Acetonide