title: Anti-babesial activity of some central kalimantan plant extracts and active oligostilbenoids from Shorea balangeran.
abstract: Bark extracts from a total of 22 species of Central Kalimantan plants were evaluated for their anti-babesial activity against Babesia gibsoni in vitro. Of these plant species, extracts of Calophyllum tetrapterum, Garcinia rigida, Lithocarpus sp., Sandoricum emarginatum, and Shorea balangeran showed more than 90% inhibition of the parasite growth at a test concentration of 1000 microg/mL. Activity-guided fractionation of the bark of S. balangeran (Dipterocarpaceae) led to the reisolation of oligostilbenoids, vaticanol A(1), B(2), and G(3). The structures were determined on the basis of spectral evidence. Compounds 1 and 3 showed complete inhibition on the growth of Babesia gibsoni in vitro at a concentration of 25 microg/mL, and compound 2 at concentration of 50 microg/mL.
authors.affiliation: Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan.
authors.lastname: Subeki
authors.forename: Shinkichi
authors.initials: S
authors.lastname: Nomura
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Matsuura
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yamasaki
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamato
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Maede
authors.forename: Ken
authors.initials: K
authors.lastname: Katakura
authors.forename: Mamoru
authors.initials: M
authors.lastname: Suzuki
authors.lastname: Trimurningsih
authors.lastname: Chairul
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Yoshihara
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001403:Babesia / Q000187:drug effects*; D001404:Babesiosis / Q000188:drug therapy; D020448:Ericales; D006801:Humans; D007214:Indonesia; D008519:Medicine, Traditional; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal; D013267:Stilbenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000981:Antiprotozoal Agents; D010936:Plant Extracts; D013267:Stilbenes