title: Subcutaneous phaeohyphomycosis caused by Cladophialophora bantiana.
abstract: Primary subcutaneous phaeohyphomycosis can rarely be caused by Cladophialophora bantiana, and we present the histologic and culture findings of such a case. A 32-year-old African American woman with systemic lupus erythematosus presented with a 2-year history of multiple, recurrent, tender, and ulcerated skin nodules with purulent drainage on her upper back. Histologic sections of the excision demonstrated features of phaeohyphomycosis. Culture findings were characteristic of C bantiana. Of interest, at age 10 she had sustained traumatic implantation of wood splinters into this area during a tornado, yet clinical symptoms of a subcutaneous infection did not manifest until she developed lupus erythematosus at age 27. Our case highlights the role of trauma and immunosuppression in the pathogenesis of subcutaneous phaeohyphomycosis.
authors.affiliation: Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9073, USA.
authors.forename: Sean M
authors.initials: SM
authors.lastname: Hussey
authors.forename: Rita
authors.initials: R
authors.lastname: Gander
authors.forename: Paul
authors.initials: P
authors.lastname: Southern
authors.forename: Mai P
authors.initials: MP
authors.lastname: Hoang
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D001203:Ascomycota / Q000302:isolation & purification* / Q000502:physiology; D001706:Biopsy; D003881:Dermatomycoses / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D016867:Immunocompromised Host; D017964:Itraconazole / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D012008:Recurrence
chemical_list: D000935:Antifungal Agents; D005938:Glucocorticoids; D017964:Itraconazole; D015725:Fluconazole; D011239:Prednisolone