Evaluation of SLC2A10 (GLUT10) as a candidate gene for type 2 diabetes and related traits in Finns.
The SLC2A10 gene encodes a glucose transporter and is located on chromosome 20q13, where evidence has been found for linkage to type 2 diabetes (T2D) in multiple studies. We investigated SLC2A10 as a T2D candidate gene in Finns. We did not confirm the previously reported association between Ala206Thr and fasting insulin and we observed no statistically significant evidence for T2D association with any single marker. We tested haplotypes for association with diabetes-related traits and observed no excess of significant results.
Mohlke
Karen L
KL
Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD, USA. mohlke@med.unc.edu
Skol
Andrew D
AD
Scott
Laura J
LJ
Valle
Timo T
TT
Bergman
Richard N
RN
Tuomilehto
Jaakko
J
Boehnke
Michael
M
Collins
Francis S
FS
D002890:Chromosomes, Human, Pair 20; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000378:metabolism; D005387:Finland; D005838:Genotype; D051246:Glucose Transport Proteins, Facilitative; D006801:Humans; D009004:Monosaccharide Transport Proteins / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D035781:Siblings
D051246:Glucose Transport Proteins, Facilitative; D009004:Monosaccharide Transport Proteins; C430746:SLC2A10 protein, human