Primate adult brain cell autotransplantation, a new tool for brain repair?
If successful, autologous brain cell transplantation is an attractive approach to repair lesions and restore function of the central nervous system. We demonstrate that monkey adult brain cells obtained from cortical biopsy and kept in culture for 4 weeks exhibit neural progenitor characteristics. After reimplantation into a lesion area of the donor cerebral cortex, these cells can successfully survive and acquire neuronal characteristics over time. These results open new perspectives in the field of brain repair and may lead to future clinical applications.
Brunet
Jean-François
JF
Department of Neurosurgery, Lausanne University Hospital, Bugnon 46, 1011 Lausanne, Switzerland. Jean-Francois.Brunet@chuv.hospvd.ch
Rouiller
Eric
E
Wannier
Thierry
T
Villemure
Jean-Guy
JG
Bloch
Jocelyne
J
D000818:Animals; D001930:Brain Injuries / Q000628:therapy*; D016380:Brain Tissue Transplantation / Q000379:methods*; D018929:Cell Culture Techniques; D002478:Cells, Cultured; D004195:Disease Models, Animal; D007150:Immunohistochemistry; D018613:Microscopy, Confocal; D009474:Neurons / Q000166:cytology* / Q000637:transplantation*; D011323:Primates; D014182:Transplantation, Autologous