title: Rhomboid-like proteins in Apicomplexa: phylogeny and nomenclature.
abstract: Rhomboids form a family of polytopic intramembrane serine proteases. In Toxoplasma gondii, an essential activity called microneme protein protease 1 (MPP1) cleaves secreted adhesive proteins within their transmembrane domains, at a site conserved in similar proteins of other Apicomplexa. Current evidence suggests that MPP1 is ubiquitous in the phylum and is encoded by a rhomboid gene. In this article, we present the current repertoire of rhomboid-like proteins in Apicomplexa using a nomenclature based on phylogenetic analyses.
authors.affiliation: Department of Biological Sciences, Sir Alexander Fleming Building, Imperial College London, UK, SW7 2AZ.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Dowse
authors.forename: Dominique
authors.initials: D
authors.lastname: Soldati
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D016782:Apicomplexa / Q000145:classification* / Q000201:enzymology / Q000235:genetics; D015815:Cell Adhesion Molecules / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D020869:Gene Expression Profiling; D017125:Genes, Protozoan; D006790:Host-Parasite Interactions; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D010802:Phylogeny; D015800:Protozoan Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D012697:Serine Endopeptidases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D015815:Cell Adhesion Molecules; C105877:MIC1 protein, Toxoplasma gondii; D008565:Membrane Proteins; D015800:Protozoan Proteins; D012697:Serine Endopeptidases