title: The effect of weight history on glucose and lipids: the Atherosclerosis Risk in Communities Study.
abstract: Few studies have examined the impact of weight history. Extant data from the Atherosclerosis Risk in Communities Study were used to compare risk factors for normal-weight (body mass index: 18.5-24.9 kg/m(2)) adults with a history of weight loss (n = 775) with those for persons with a history of weight maintenance (n = 5,164). In this 1987-1998 US study, the authors also compared risk factors for pre-obese (body mass index: 25.0-29.9 kg/m(2)) adults with a history of weight gain (n = 1,296) versus weight maintenance (n = 6,721). They used mixed-models regression to adjust for ethnicity, gender, age, education, field center, smoking, alcohol consumption, follow-up time, and follow-up body mass index. Compared with adults with a history of weight maintenance, adults with a 3-year history of weight loss had more favorable total and low density lipoprotein cholesterol levels and similar glucose, high density lipoprotein cholesterol, and triglyceride levels. In contrast, pre-obese adults with a 3-year history of weight gain had equivalent glucose and lipid levels at follow-up compared with adults with a history of weight maintenance. These findings suggest that, in addition to current weight, weight history may impact glucose and lipid levels.
authors.affiliation: Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599, USA. Kim_Truesdale@unc.edu
authors.forename: Kimberly P
authors.initials: KP
authors.lastname: Truesdale
authors.forename: June
authors.initials: J
authors.lastname: Stevens
authors.forename: Jianwen
authors.initials: J
authors.lastname: Cai
mesh_terms: D000428:Alcohol Drinking / Q000453:epidemiology; D001161:Arteriosclerosis / Q000097:blood* / Q000453:epidemiology*; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D001835:Body Weight; D015984:Causality; D015897:Comorbidity; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008396:Maryland / Q000453:epidemiology; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D008922:Mississippi / Q000453:epidemiology; D009657:North Carolina / Q000453:epidemiology; D009765:Obesity / Q000453:epidemiology; D044469:Racial Groups / Q000706:statistics & numerical data; D012016:Reference Values; D012307:Risk Factors; D017678:Sex Distribution; D012907:Smoking / Q000453:epidemiology; D012959:Socioeconomic Factors
chemical_list: D001786:Blood Glucose; D008055:Lipids