title: Daptomycin: a novel cyclic lipopeptide antimicrobial.
abstract: OBJECTIVE
  The development, activity, pharmacokinetics, pharmacodynamics, clinical efficacy, adverse effects, and dosage and administration of daptomycin are reviewed.
  
  
  CONCLUSIONS
  Daptomycin, a novel cyclic lipopeptide antimicrobial, is bactericidal against a range of gram-positive bacteria, including many multiple-drug-resistant isolates. It has only minimal activity against anaerobic bacteria and no activity against gram-negative bacteria. Daptomycin exhibits linear pharmacokinetics, and the plasma concentration-versus-time relationship is best described by a two-compartment model with first-order elimination. The initial bactericidal activity is rapid, extensive, and concentration related. In clinical trials, daptomycin has shown efficacy in treating complicated skin and skin-structure infections (CSSSIs); the drug carries FDA-approved labeling for same. The adverse effects of daptomycin appear comparable to those of vancomycin and semisynthetic penicillins. The dosage for CSSSIs is 4 mg/kg by i.v. infusion every 24 hours.
  
  
  CONCLUSIONS
  Daptomycin is bactericidal against gram-positive organisms and offers an option in the treatment of CSSSIs.
authors.affiliation: Loyal University Medical Center, Maywood, IL, USA.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Schriever
authors.forename: Cristina
authors.initials: C
authors.lastname: Fernández
authors.forename: Keith A
authors.initials: KA
authors.lastname: Rodvold
authors.forename: Larry H
authors.initials: LH
authors.lastname: Danziger
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D019540:Area Under Curve; D002986:Clinical Trials as Topic; D017576:Daptomycin / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D004347:Drug Interactions; D024881:Drug Resistance, Bacterial; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin