Restoring permeability barrier function to outer membrane.
A recent issue of Cell published two papers resulting from the collaboration between the Kahne and Silhavy laboratories [1,2]. These studies, possibly initiated as an effort to identify the target of action of vancomycin with lipophilic substitutions, resulted in the discovery of a protein complex involved in the assembly of outer membrane proteins.
Nikaido
Hiroshi
H
Department of Molecular and Cell Biology, University of California, Berkeley 94720-3202, USA.
D000900:Anti-Bacterial Agents / Q000378:metabolism; D001425:Bacterial Outer Membrane Proteins / Q000502:physiology*; D002463:Cell Membrane Permeability; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D009154:Mutation
D000900:Anti-Bacterial Agents; D001425:Bacterial Outer Membrane Proteins