Neuronal regulation and function of natriuretic peptide receptor C.
The neuromodulatory effect of natriuretic peptides is probably the best example of a whole organ response mediated by natriuretic peptide C receptors (NPR-Cs). Both NPR-C specific agonists and ablation experiments utilizing NPR-C specific antibodies or antisense oligonucleotides demonstrated the essential signaling role of the NPR-C in these neuromodulatory responses. Our most recent studies utilize peptides representing the NPR-C intracellular region to elucidate the specific signaling region of the NPR-C. These studies have identified an inhibitory influence of NPR-C on adrenergic neurotransmission by a calcium-dependent process.
Trachte
George
G
Department of Pharmacology, University of Minnesota-Duluth, School of Medicine, 1036 University Drive, Duluth, MN 55812, USA. gtracht1@d.umn.edu
D000818:Animals; D002118:Calcium / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism*; D018377:Neurotransmitter Agents; D009841:Oligonucleotides / Q000737:chemistry; D016376:Oligonucleotides, Antisense / Q000494:pharmacology; D016716:PC12 Cells; D010455:Peptides / Q000737:chemistry; D051381:Rats; D017461:Receptors, Atrial Natriuretic Factor / Q000096:biosynthesis* / Q000235:genetics*; D015398:Signal Transduction
D018377:Neurotransmitter Agents; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense; D010455:Peptides; D017461:Receptors, Atrial Natriuretic Factor; C073616:atrial natriuretic factor receptor C; D002118:Calcium