title: Simulations of motor unit number estimation techniques.
abstract: Motor unit number estimation (MUNE) is an electrodiagnostic procedure used to evaluate the number of motor axons connected to a muscle. All MUNE techniques rely on assumptions that must be fulfilled to produce a valid estimate. As there is no gold standard to compare the MUNE techniques against, we have developed a model of the relevant neuromuscular physiology and have used this model to simulate various MUNE techniques. The model allows for a quantitative analysis of candidate MUNE techniques that will hopefully contribute to consensus regarding a standard procedure for performing MUNE.
authors.affiliation: Department of Biomedical Engineering, University of Alberta, Edmonton, Canada.
authors.forename: Lora A
authors.initials: LA
authors.lastname: Major
authors.forename: Kelvin E
authors.initials: KE
authors.lastname: Jones
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000465:Algorithms; D001369:Axons / Q000502:physiology*; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D004056:Differential Threshold / Q000502:physiology; D004576:Electromyography / Q000379:methods*; D008959:Models, Neurological; D009046:Motor Neurons / Q000502:physiology*; D009119:Muscle Contraction / Q000502:physiology; D018485:Muscle Fibers, Skeletal / Q000502:physiology; D018482:Muscle, Skeletal / Q000294:innervation* / Q000502:physiology*