title: Cross-section measurement of the 169 Tm p,n reaction for the production of the therapeutic radionuclide 169 Yb and comparison with its reactor-based generation.
abstract: The radionuclide (169)Yb (T(1/2)=32.0 d) is potentially important for internal radiotherapy. It is generally produced using a nuclear reactor. In this work the possibility of its production at a cyclotron was investigated. A detailed determination of the excitation function of the (169)Tm(p,n)(169)Yb reaction was done over the proton energy range up to 45 MeV using the stacked-foil technique and high-resolution gamma-ray spectrometry. The integral yield of (169)Yb was calculated. Over the optimum energy range E(P)=16-->7 MeV the yield amounts to 1.5 MBq/micro Ah and is thus rather low. A comparison of this production route with the established (168)Yb(n,gamma)(169)Yb reaction at a nuclear reactor is given. The (169)Yb yield via the reactor route is by several orders of magnitude higher than by the cyclotron method. The latter procedure, however, leads to "no-carrier-added" product.
authors.affiliation: Institut für Nuklearchemie, Forschungszentrum Jülich Gmb H, D-52425 Jülich, Germany.
authors.forename: I
authors.initials: I
authors.lastname: Spahn
authors.forename: S
authors.initials: S
authors.lastname: Takács
authors.forename: Yu N
authors.initials: YN
authors.lastname: Shubin
authors.forename: F
authors.initials: F
authors.lastname: Tárkányi
authors.forename: H H
authors.initials: HH
authors.lastname: Coenen
authors.forename: S M
authors.initials: SM
authors.lastname: Qaim
mesh_terms: D007553:Isotope Labeling / Q000379:methods*; D009688:Nuclear Reactors; D011829:Radiation Dosage; D011868:Radioisotopes / Q000737:chemistry* / Q000627:therapeutic use*; D011874:Radiometry / Q000379:methods*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D013932:Thulium / Q000737:chemistry*; D015018:Ytterbium / Q000737:chemistry* / Q000627:therapeutic use*
chemical_list: D011868:Radioisotopes; D019275:Radiopharmaceuticals; D013932:Thulium; D015018:Ytterbium