[Discovery of biomarkers in the serum from patients with hypertensive disorder complicating pregnancy].
OBJECTIVE
To distinguish patients with hypertensive disorder complicating pregnancy from healthy pregnant women by examining serum protein fingerprinting.


METHODS
Eight patients with hypertensive disorder complicating pregnancy and eight healthy pregnant women were tested by surface-enhanced laser desorption/ionization-time of flight-mass spectrometry (SELDI-TOF-MS).


RESULTS
At the molecular mass/charge (M/Z) value range from 1300-14,000, the content of three proteins with different M/Z values was obviously different. In spectrometry of patients with hypertensive disorder complicating pregnancy, proteins with M/Z 1325, 13,749 were significantly higher than that in healthy pregnant women (P < 0.05), that with M/Z 3245 was significantly lower than in healthy pregnant women (P < 0.05).


CONCLUSIONS
There is difference in serum protein fingerprinting between healthy pregnant women and patients with hypertensive disorder complicating pregnancy.
Lü
Ya-jie
YJ
Department of Obstetrics and Gynecology, Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China.
Li
Li
L
Yu
Li-li
LL
Xu
Yang
Y
D000328:Adult; D015415:Biomarkers / Q000097:blood* / Q000737:chemistry; D001774:Blood Chemical Analysis; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood* / Q000175:diagnosis*; D011247:Pregnancy; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D055815:Young Adult
D015415:Biomarkers