title: The effects of extracorporeal shock wave lithotripsy on antioxidant enzymes in erythrocytes.
abstract: The effects of extracorporeal shock wave lithotripsy (ESWL) on patients undergoing ESWL for renal stone treatment have been studied using activities of glucose-6-phosphate dehydrogenase (G6PDH), superoxide dismutase (SOD) and catalase (CAT), and levels of malondialdehyde (MDA) in the erythrocyte haemolysate. The study included 23 patients (eight women, 15 men with an age range of 23-57 years). Blood samples were taken 5 min before ESWL, in addition to 1 h and 5 days after termination of treatment. Enzyme activities and MDA levels in erythrocytes were measured spectrophotometrically. When compared with the values obtained before ESWL, erythrocyte G6PDH (p = 0.015), SOD (p = 0.036) and CAT (p = 0.01) activities were found to be significantly reduced at the first hour after ESWL. On the fifth day after ESWL, erythrocyte enzyme activities were normalized to the values obtained before ESWL. Although there was a significant difference between values before and 1 h after ESWL (p = 0.003), no difference was detected between 1 h after ESWL and 5 days after ESWL (p > 0.05) in terms of MDA values. The findings of the present study revealed that erythrocyte lipid peroxidation might be induced and antioxidative defence mechanism may be transiently impaired by ESWL.
authors.affiliation: Department of Urology, School of Medicine, Atatürk University, Erzurum, Turkey. aksoyyilmaz@yahoo.com
authors.forename: Yilmaz
authors.initials: Y
authors.lastname: Aksoy
authors.forename: Ismail
authors.initials: I
authors.lastname: Malkoc
authors.forename: Ali Fuat
authors.initials: AF
authors.lastname: Atmaca
authors.forename: Hülya
authors.initials: H
authors.lastname: Aksoy
authors.forename: Konca
authors.initials: K
authors.lastname: Altinkaynak
authors.forename: Fatih
authors.initials: F
authors.lastname: Akcay
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006801:Humans; D007669:Kidney Calculi / Q000097:blood / Q000628:therapy*; D015227:Lipid Peroxidation; D008096:Lithotripsy / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D005954:Glucosephosphate Dehydrogenase; D002374:Catalase; D013482:Superoxide Dismutase