Treatment of human disseminated strongyloidiasis with a parenteral veterinary formulation of ivermectin.
There are no parenteral antihelminthic drugs licensed for use in humans. We report the successful treatment of disseminated strongyloidiasis with a parenteral veterinary formulation of ivermectin in a patient presenting with severe malabsorption and paralytic ileus. To our knowledge, ivermectin levels are reported for the first time in this situation.
Marty
Francisco M
FM
Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA. fmarty@partners.org
Lowry
Colleen M
CM
Rodriguez
Martin
M
Milner
Danny A
DA
Pieciak
Walter S
WS
Sinha
Anushua
A
Fleckenstein
Lawrence
L
Baden
Lindsey R
LR
D000818:Animals; D000977:Antiparasitic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001706:Biopsy; D004386:Duodenum / Q000469:parasitology / Q000473:pathology; D005243:Feces / Q000469:parasitology; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D007559:Ivermectin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D017171:Strongyloides stercoralis / Q000187:drug effects* / Q000302:isolation & purification; D013322:Strongyloidiasis / Q000188:drug therapy* / Q000469:parasitology / Q000473:pathology; D016896:Treatment Outcome; D014730:Veterinary Medicine / Q000379:methods
D000977:Antiparasitic Agents; D007559:Ivermectin