title: Cytotoxic steroidal saponins from the rhizomes of Asparagus oligoclonos.
abstract: Two new steroidal saponins, aspaoligonins A (2) and B (3), were isolated from the methanolic extract of the rhizomes of Asparagus oligoclonos together with a known spirostanol saponin, asparanin A (1). Aspaoligonins A and B were characterized as (25S*)-5beta-spirostan-3beta,17alpha-diol 3-O-beta-D-glucopyranosyl (1-->2)-beta-D-glucopyranoside and (25S*)-5beta-spirostan-3beta,17alpha-diol 3-O-alpha-L-rhamnopyanosyl (1-->4)-[beta-D-xylopyranosyl-(1-->2)]-beta-D-glucopyranoside, respectively, by spectrometric analyses including HRFABMS and 2D NMR. Compounds 1-3 were cytotoxic against five human tumor cell lines with IC50 values of 2.05-2.84 microg/mL.
authors.affiliation: Ginseng & Medicinal Crops Division, National Institute of Crop Science (NICS), Rural Development Administration (RDA), Suwon 441-857, Korea.
authors.forename: Geum-Soog
authors.initials: GS
authors.lastname: Kim
authors.forename: Hyun-Tae
authors.initials: HT
authors.lastname: Kim
authors.forename: Jae-Duck
authors.initials: JD
authors.lastname: Seong
authors.forename: Sei-Ryang
authors.initials: SR
authors.lastname: Oh
authors.forename: Chong-Ock
authors.initials: CO
authors.lastname: Lee
authors.forename: Jin-Ki
authors.initials: JK
authors.lastname: Bang
authors.forename: Nak-Sul
authors.initials: NS
authors.lastname: Seong
authors.forename: Kyung-Sik
authors.initials: KS
authors.lastname: Song
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D027761:Asparagus Plant / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D007723:Korea; D010946:Plants, Medicinal / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013150:Spirostans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D013150:Spirostans; C501797:aspaoligonin A; C501798:aspaoligonin B