[Comparative study of the long-term behavioral effects of noopept and piracetam in adult male rats and female rats in postnatal period].
Adult male and female rats were treated with the peptide nootrope drug noopept (daily dose, 0.1 mg/kg) and piracetam (200 mg/kg). In the period from 8th to 20th day, both drugs (cognitive enhancers) suppressed the horizontal and vertical activity and the anxiety in test animals as compared to the control group treated with 0.9 % aqueous NaCl solution. Early postnatal injections of the nootropes influenced neither the morphology development nor the behavior of adult female rats in the plus maze, extrapolational escape, passive avoidance, and pain sensitivity threshold tests. Animals in the "intact" group (having received neither drugs not physiological solution, that is, developing in a poor sensor environment), showed less pronounced habituation in the open field test as compared to the control and drug treated groups.
Voronina
T A
TA
Guzevatykh
L S
LS
Trofimov
S S
SS
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004151:Dipeptides / Q000008:administration & dosage*; D005260:Female; D008137:Longitudinal Studies; D008297:Male; D018697:Nootropic Agents / Q000008:administration & dosage*; D010889:Piracetam / Q000008:administration & dosage*; D051381:Rats
D004151:Dipeptides; D018697:Nootropic Agents; C103871:ethyl phenylacetyl-Pro-Gly; D010889:Piracetam