[Albumin dialysis in complex intensive therapy].
After cardiac surgery, acute hepatic failure (AHF) is a most common component of the multiple organ dysfunction syndrome (MODS) and associated with high mortality. In the past year, A. N. Bakulev Research Center of Cardiovascular Surgery, Russian Academy of Medical Sciences, has performed 10 postoperative MARS therapy sessions in patients with MODS caused by the development of low cardiac output. The results of the study suggest that MARS therapy has no negative impact on circulatory parameters under adequate thermoregulation monitoring. During albumin dialysis, there is a reduction in bilirubin levels by the end of a session, a significant decrease in the parameters of uremic intoxication: urea and creatinine. The studies of the values of albumin in different constituents of an extracorporeal contour have indicated the preservation of a significant gradient of the protein concentrations between the patient's blood and a dialyzing solution, which is indicative of the absence of laboratory significant permeability of a MARS filter for these molecules. Thus, the first experience in using MARD therapy suggests that it may be successfully used in patients with MODS after cardiacsurgery.
Bokeriia
L A
LA
Iarustovskiĭ
M B
MB
Geptner
R A
RA
Grigor'iants
R G
RG
Tomarovskiĭ
O V
OV
D000293:Adolescent; D000328:Adult; D000368:Aged; D018376:Cardiovascular Abnormalities / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D003422:Critical Care; D006801:Humans; D007223:Infant; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000628:therapy*; D011184:Postoperative Period; D006435:Renal Dialysis / Q000295:instrumentation*; D012709:Serum Albumin / Q000378:metabolism*; D016060:Sorption Detoxification / Q000379:methods*
D012709:Serum Albumin