title: Oxidative and hydrolytic stability of a novel acrylic terpolymer for biomedical applications.
abstract: Oxidative and hydrolytic biostability assessment was carried out on a novel acrylic material made of hexamethyl methacrylate (HMA), methyl methacrylate (MMA), and methacrylic acid (MAA). To simulate the in vivo microenvironment, solutions of H2O2/CoCl2 and buffered solutions of cholesterol esterase (CE) and phospholipase A2 (PLA) were used. As controls, film specimens were incubated in deionized water. Samples were incubated in these solutions at 37 degrees C for 10 weeks before physical and mechanical properties were evaluated by size exclusion chromatography (SEC), 1H- nuclear magnetic resonance (1H-NMR), acid-base titration, and Instron tensile testing. The results from this study indicate excellent biostability of HMA-MMA-MAA terpolymers and thus their potential for use in biomedical devices for long-term implantation.
authors.affiliation: Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA. anveleva@unity.ncsu.edu
authors.forename: Anka N
authors.initials: AN
authors.lastname: Veleva
authors.forename: Saad A
authors.initials: SA
authors.lastname: Khan
authors.forename: Stuart L
authors.initials: SL
authors.lastname: Cooper
mesh_terms: D000180:Acrylic Resins / Q000138:chemical synthesis / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D002021:Buffers; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002850:Chromatography, Gel; D003035:Cobalt / Q000737:chemistry; D020724:Elastomers; D006861:Hydrogen Peroxide / Q000737:chemistry; D006868:Hydrolysis; D008247:Lysosomes / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry; D020366:Methylmethacrylate / Q000737:chemistry; D010084:Oxidation-Reduction; D010741:Phospholipases A / Q000737:chemistry; D054467:Phospholipases A2; D019904:Polymethyl Methacrylate / Q000138:chemical synthesis / Q000737:chemistry; D002787:Sterol Esterase / Q000737:chemistry; D013718:Tensile Strength
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials; D002021:Buffers; D020724:Elastomers; D008689:Methacrylates; D020366:Methylmethacrylate; C008384:methacrylic acid; D003035:Cobalt; D019904:Polymethyl Methacrylate; D006861:Hydrogen Peroxide; D002787:Sterol Esterase; D010741:Phospholipases A; D054467:Phospholipases A2; C018021:cobaltous chloride