title: Association between platelet activation and fibrinolysis in acute stroke patients.
abstract: We aimed to evaluate platelet activation and fibrinolyis in acute atherosclerotic ischemic stroke patients to clarify the relationship between them. Plasma P-selectin antigen, tissue plasminogen activator (tPA) antigen and activity, and plasminogen activator inhibitor-1 (PAI-1) activity were determined in 60 acute atherosclerotic stroke patients and matched control subjects. All patients were examined within 72 h after stroke onset. The levels of P-selectin, tPA antigen, and PAI-1 activity were all significantly higher in stroke patients compared with controls (all p < 0.0001); the level of tPA activity was significantly lower in patients than that in controls (p < 0.0001). These markers did not change much at different time points within 72 h. In stroke group, P-selectin concentration was highly correlated to PAI-1 activity (r = 0.8433, p < 0.001), but not to tPA antigen (r = -0.1752, p > 0.05), and tPA activity (r = 0.2465, p>0.05), which was further confirmed in the multiple linear regression analysis (F = 47.052, p < 0.0001). Our results indicate increased platelet activation and decreased fibrinolysis in patients with acute atherosclerotic ischemic stroke. Increased platelet activation may be correlated with decreased fibrinolysis.
authors.affiliation: Department of Neurology, The Second Affiliated Hospital, Zhengzhou University, Zhengzhou 450003, PR China. jwang79@jhmi.edu
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Jianzhang
authors.initials: J
authors.lastname: Li
authors.forename: Qiqiang
authors.initials: Q
authors.lastname: Liu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000150:complications / Q000276:immunology*; D005260:Female; D005342:Fibrinolysis / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000276:immunology*; D017395:Plasminogen Activator Inhibitor 1 / Q000276:immunology*; D015539:Platelet Activation / Q000276:immunology*; D013223:Statistics as Topic; D020521:Stroke / Q000209:etiology / Q000276:immunology*; D019396:Tissue Polypeptide Antigen / Q000276:immunology*
chemical_list: D019007:P-Selectin; D017395:Plasminogen Activator Inhibitor 1; D019396:Tissue Polypeptide Antigen