title: Correlation between strand asymmetry and phylogeny in mitochondrial DNA.
abstract: An evolutionary distance is introduced in order to propose an efficient and feasible procedure for phylogeny studies. Our analysis are based on the strand asymmetry property of mitochondrial DNA, but can be applied to other genomes. Comparison of our results with those reported in conventional phylogenetic trees, gives confidence about our approximation. Our findings support the hypotheses about the origin of the skew and its dependence upon evolutionary pressures, and improves previous efforts on using the strand asymmetry property of genomes for phylogeny inference. For the evolutionary distance introduced here, we observe that the more adequate technique for tree reconstructions correspond to an average link method which employs a sequential clustering algorithm.
authors.affiliation: Centro Nacional de Secuenciación y Análisis de Acidos Nucleicos CeSAAN, IVIC, Apartado Postal 21827, Caracas 1020A, Venezuela.
authors.forename: J
authors.initials: J
authors.lastname: Barral P
authors.forename: L
authors.initials: L
authors.lastname: Cantini
authors.forename: A
authors.initials: A
authors.lastname: Hasmy
authors.forename: J
authors.initials: J
authors.lastname: Jiménez
authors.forename: A
authors.initials: A
authors.lastname: Marcano
mesh_terms: D000465:Algorithms; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D016000:Cluster Analysis; D004272:DNA, Mitochondrial; D019143:Evolution, Molecular; D020869:Gene Expression Profiling; D006801:Humans; D008957:Models, Genetic; D008969:Molecular Sequence Data; D010363:Pattern Recognition, Automated / Q000379:methods; D010802:Phylogeny; D011687:Purines
chemical_list: D004272:DNA, Mitochondrial; D011687:Purines; C030985:purine