title: [Advances in researches on the onset and duration of the action of sildenafil].
abstract: Sildenafil is an orally effective therapy for the treatment of men with erectile dysfunction (ED). It is a specific and selective inhibitor of phosphodiesterase type 5 (PDE5). This paper reviews the researches on the pharmacokinetics, the onset and duration of the action of Sildenafil.
authors.affiliation: Department of Urology, Guangdong Provincial People's Hospital, Guangzhou, Guangdong 510080, China. andrology@126.com
authors.forename: Huai-Peng
authors.initials: HP
authors.lastname: Wang
authors.forename: Xiao-Yong
authors.initials: XY
authors.lastname: Pu
mesh_terms: D000818:Animals; D007172:Erectile Dysfunction / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D010726:Phosphodiesterase Inhibitors / Q000493:pharmacokinetics* / Q000627:therapeutic use; D010879:Piperazines / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011687:Purines / Q000493:pharmacokinetics / Q000627:therapeutic use; D051381:Rats; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate