Endoglin gene insertion polymorphism not associated with aneurysmal subarachnoid hemorrhage.
OBJECTIVE
Data concerning an association between the ENG gene intronic insertion polymorphism and intracrahial aneurysms (IAs) remain inconsistent. In this study the authors investigated whether this polymorphism is associated with a subarachnoid hemorrhage (SAH) caused by a ruptured IA in a Polish population.


METHODS
One hundred nineteen patients with aneurysmal SAH and 119 sex-matched healthy volunteers were studied. The insertion ENG gene polymorphism in intron 7 was identified using polymerase chain reaction-single-strand chain polymorphism method. The distribution of the insertion allele did not differ between the SAH (13%) and control (16%) cases (p = 0.36). The homozygous insertion/insertion genotype frequencies in these cases were 3.4 and 0.8%, respectively (p = 0.18).


CONCLUSIONS
The authors failed to find an association between the intronic insertion polymorphism of the ENG gene and aneurysmal SAH in a Polish population.
Pera
Joanna
J
Department of Neurology, Jagiellonian University, Krakow, Poland. pera@su.krakow.pl
Slowik
Agnieszka
A
Dziedzic
Tomasz
T
Borratynska
Anna
A
Rog
Teresa M
TM
Betlej
Marek
M
Czepko
Ryszard
R
Szczudlik
Andrzej
A
D015703:Antigens, CD; D000071063:Endoglin; D005260:Female; D006801:Humans; D007438:Introns / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011044:Poland; D011110:Polymorphism, Genetic; D011956:Receptors, Cell Surface; D013345:Subarachnoid Hemorrhage / Q000235:genetics*; D019010:Vascular Cell Adhesion Molecule-1 / Q000235:genetics*; D044465:White People / Q000235:genetics
D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface; D019010:Vascular Cell Adhesion Molecule-1