Quantitative changes in thyroid lymphoid cells as a marker of malignancy.
OBJECTIVE
To investigate the possibility of using morphometric changes in lymphoid cells in thyroid tissue as a marker of malignant tumors.


METHODS
Morphometry of biopsy material was performed with a semiautomated, computerized image analyzer.


RESULTS
Nine features were selected. These features formed the criteria for differentiation between malignant and benign disease. Equations for the calculation of a weighting coefficient for each feature and a diagnostic index were derived. The values for the diagnostic index for the groups with malignant and benign pathology differed significantly.


CONCLUSIONS
One can determine the presence of a malignant tumor in the thyroid gland from the diagnostic index value.
Kirillov
Vladimir A
VA
Laboratory for Electron Paramagnetic Resonance-Dosimetry and Cytology, Belarusian State Medical University, 23 Philimonova Street, Room 416, 220114 Minsk, Belarus. kirillov@msmi.minsk.by
Stebenyaeva
Elena E
EE
Paplevka
Andrey A
AA
Demidchik
Evgeny P
EP
D014408:Biomarkers, Tumor / Q000097:blood; D006801:Humans; D008214:Lymphocytes / Q000097:blood / Q000473:pathology*; D013961:Thyroid Gland / Q000473:pathology; D013964:Thyroid Neoplasms / Q000473:pathology*
D014408:Biomarkers, Tumor