title: SECISDesign: a server to design SECIS-elements within the coding sequence.
abstract: CONCLUSIONS
  SECISDesign is a server for the design of SECIS-elements and arbitrary RNA-elements within the coding sequence of an mRNA. The element has to satisfy both structure and sequence constraints. At the same time, a certain amino acid similarity to the original protein has to be kept. The designed sequence can be used for recombinant expression of selenoproteins in Escherichia coli.
  
  
  BACKGROUND
  The server is available at http://www.bio.inf.uni-jena.de/Software/SECISDesign/index.html.
authors.affiliation: Friedrich-Schiller-University Jena, Institute of Computer Science, Ernst-Abbe-Platz 2, 07743 Jena, Germany.
authors.forename: Anke
authors.initials: A
authors.lastname: Busch
authors.forename: Sebastian
authors.initials: S
authors.lastname: Will
authors.forename: Rolf
authors.initials: R
authors.lastname: Backofen
mesh_terms: D017076:Computer-Aided Design; D004251:DNA Transposable Elements / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D020407:Internet; D015202:Protein Engineering / Q000379:methods*; D011506:Proteins / Q000235:genetics* / Q000378:metabolism*; D011994:Recombinant Proteins / Q000096:biosynthesis; D051140:Selenoproteins; D020539:Sequence Analysis, Protein / Q000379:methods*; D017423:Sequence Analysis, RNA / Q000379:methods*; D012984:Software
chemical_list: D004251:DNA Transposable Elements; D011506:Proteins; D011994:Recombinant Proteins; D051140:Selenoproteins