title: [Effects of fluvastatin on blood levels of inflammatory cytokines in patients with unstable angina undergoing percutaneous coronary intervention].
abstract: OBJECTIVE
  To investigate the effect of fluvastatin on blood levels of c-reactive protein (CRP), tumor necrosis factor alpha (TNFalpha) and cardiac troponin I (cTnI) in patients with unstable angina undergoing percutaneous coronary intervention (PCI).
  
  
  METHODS
  Sixty patients who underwent PCI from July 2002 to April 2004 in our hospital were randomized into two groups: control group; fluvastatin group (40 mg/d). Serum levels of CRP, TNFalpha and cTnI were measured before and after two weeks treatment (in the early morning of the procedure) and at 24 hours after the procedure.
  
  
  RESULTS
  The serum levels of CRP, TNFalpha and cTnI in fluvastatin group were distinctly lower than those in control group before (P < 0.01) and after the procedure (P < 0.01), respectively.
  
  
  CONCLUSIONS
  The result suggested that PCI could lead to a detectable increase in serum levels of CRP, TNFalpha and cTnI in patients with coronary heart disease; Fluvastatin could significantly decrease the serum levels of CRP, TNFalpha and cTnI in patients with coronary heart disease; Fluvastatin could also decrease the serum levels of CRP, TNFalpha and cTnI in patients with PCI.
authors.affiliation: Department of Cardiology, Xiangfan Central Hospital, Xiangfan, Hubei 441021, China. qshan12@hotmail
authors.forename: Qing-shan
authors.initials: QS
authors.lastname: Shen
authors.forename: Yong-sheng
authors.initials: YS
authors.lastname: Liu
authors.forename: Rui
authors.initials: R
authors.lastname: Zhu
authors.forename: Du-guan
authors.initials: DG
authors.lastname: Fu
authors.forename: Yong-qian
authors.initials: YQ
authors.lastname: Tang
authors.forename: Hong
authors.initials: H
authors.lastname: Tao
authors.forename: Su-zhen
authors.initials: SZ
authors.lastname: Li
authors.forename: Jian-wen
authors.initials: JW
authors.lastname: Ye
mesh_terms: D000789:Angina, Unstable / Q000097:blood* / Q000188:drug therapy*; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D002097:C-Reactive Protein / Q000378:metabolism; D005229:Fatty Acids, Monounsaturated / Q000627:therapeutic use*; D000077340:Fluvastatin; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D019210:Troponin I / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000924:Anticholesteremic Agents; D005229:Fatty Acids, Monounsaturated; D007211:Indoles; D019210:Troponin I; D014409:Tumor Necrosis Factor-alpha; D000077340:Fluvastatin; D002097:C-Reactive Protein