[Sarcoidosis: new therapeutic and pathogenic aspects for an "old" disease].
Sarcoidosis is a multisystemic disorder of unknown etiology characterized by non-caseating epithelioid granuloma. Clinical features are protean and the lack of a specific diagnostic test can make diagnosis difficult. The cause of this disease is still unknown but the diverse manifestations of this disorder help fuel the prevailing hypothesis that sarcoidosis has more than one cause each of which may promote a different pattern of illness. Recent progress, especially in immunology and molecular biology, has advanced our understanding of the pathogenesis of the disease and improved our ability to diagnose and treat this complex condition. This article gives an overview about current concepts in sarcoidosis and focus on immunopathogenic and therapeutic aspects.
Zuber
J P
JP
Service d'immunologie et d'allergie, Département de médecine, CHUV, 1011 Lausanne. jean-philippe.zuber@chuv.hospvd.ch
Spertini
F
F
Leimgruber
A
A
Bart
P A
PA
D003937:Diagnosis, Differential; D006801:Humans; D015994:Incidence; D012307:Risk Factors; D012507:Sarcoidosis / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy*