title: Diabetes insipidus caused by isolated intracranial metatstases in patient with breast cancer.
abstract: We present a case of late recurrence of breast cancer manifested with diabetes insipidus caused by isolated intracranial metastases. A 57-year-old postmenopausal woman was diagnosed with breast cancer and underwent radical mastectomy, without any adjuvant therapy. Seventeen years later, she presented with polyuria, polydipsia, weight loss, weakness, diffuse bone pain, hoarseness and mild dyspnoea. Cranial CT revealed several dural masses in the frontal, parietal and occipital lobes and along the falx cerebri. The diagnosis of central diabetes insipidus without impairment of anterior pituitary function was based on the clinical symptoms, laboratory tests and imaging findings. The patient was successfully treated with desmopressin acetate and letrozole, and remained alive and ambulating 22 months after initial presentation with diabetes insipidus.
authors.affiliation: Department of Oncology, Soroka University Medical Center, P.O. Box 151, Beer Sheva, 84101, Israel.
authors.forename: Dmitri
authors.initials: D
authors.lastname: Bobilev
authors.forename: Ilan
authors.initials: I
authors.lastname: Shelef
authors.forename: Konstantin
authors.initials: K
authors.lastname: Lavrenkov
authors.forename: Margarita
authors.initials: M
authors.lastname: Tokar
authors.forename: Sofia
authors.initials: S
authors.lastname: Man
authors.forename: Amalia
authors.initials: A
authors.lastname: Baumgarten
authors.forename: Samuel
authors.initials: S
authors.lastname: Ariad
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D003919:Diabetes Insipidus / Q000188:drug therapy / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D000077289:Letrozole; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000150:complications / Q000188:drug therapy / Q000556:secondary*; D008875:Middle Aged; D009570:Nitriles / Q000627:therapeutic use; D010911:Pituitary Neoplasms / Q000150:complications / Q000188:drug therapy / Q000556:secondary*; D012076:Renal Agents / Q000627:therapeutic use; D014230:Triazoles / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D009570:Nitriles; D012076:Renal Agents; D014230:Triazoles; D000077289:Letrozole; D003894:Deamino Arginine Vasopressin