title: Older liver graft transplantation, cholestasis and synthetic graft function.
abstract: Older liver grafts are often discarded because of conservative selection criteria. We report on our clinical experience with graft-age related outcome. Patients transplanted with livers older than 70 years (70.2-80.2 years, n = 38) were compared with controls transplanted with livers younger than 70 years. Pairs were matched for age, gender, indication and cold ischemic time. Mean donor age was 73.4 +/- 2 vs. 39 +/- 16 years. Patient and graft survival did not differ between both groups after 1-year follow-up (P = 0.19 and P = 0.24 respectively). Retransplantation rate was 10.5% vs. 5.3% (P = 0.40). Initial poor function occurred in two patients in the study group versus four patients in the control group (P = 0.69). The incidence of rejection episodes was comparable. Parameters of cholestasis and protein synthesis showed no difference 1-year post-transplant. Mean age of donor organs in matched pairs group B was near by half of that in the older donor group A (39.0 vs. 73.4 years). Post-transplant outcome as indicated by patient and graft survival was comparable between both groups. Donor organ age had no impact on postoperative organ function. We recommend to accept liver grafts from organ donors older than 70 years to expand the donor pool.
authors.affiliation: Department of General, Visceral and Transplant Surgery, Charité, Campus Virchow Klinikum, Universitätsmedizin Berlin, Berlin, Germany. dietmar.borchert@doctors.org.uk
authors.forename: Dietmar
authors.initials: D
authors.lastname: Borchert
authors.forename: Matthias
authors.initials: M
authors.lastname: Glanemann
authors.forename: Martina
authors.initials: M
authors.lastname: Mogl
authors.forename: Jan M
authors.initials: JM
authors.lastname: Langrehr
authors.forename: Peter
authors.initials: P
authors.lastname: Neuhaus
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002779:Cholestasis / Q000150:complications*; D005260:Female; D006085:Graft Survival; D006801:Humans; D008115:Liver Regeneration; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D014176:Protein Biosynthesis; D012189:Retrospective Studies; D014019:Tissue Donors