title: Polarity proteins in axon specification and synaptogenesis.
abstract: The neuron is a prime example of a highly polarized cell. It is becoming clear that conserved protein complexes, which have been shown to regulate polarity in such diverse systems as the C. elegans zygote and mammalian epithelia, are also required for neuronal polarization. This review considers the role of these polarity proteins in axon specification and synaptogenesis.
authors.affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.
authors.forename: Giselle R
authors.initials: GR
authors.lastname: Wiggin
authors.forename: James P
authors.initials: JP
authors.lastname: Fawcett
authors.forename: Tony
authors.initials: T
authors.lastname: Pawson
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism*; D019521:Body Patterning; D016764:Cell Polarity / Q000502:physiology*; D008959:Models, Neurological; D009474:Neurons / Q000378:metabolism; D011506:Proteins / Q000145:classification / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D013569:Synapses / Q000502:physiology*
chemical_list: D011506:Proteins