[Thalidomide: new indications for an old drug].
Thalidomide has several mechanisms of action: a hypnosedative effect, several immuno-modulatory properties and an anti-angiogenic action. Thalidomide has been used in several cutaneous inflammatory disorders (such as erythema nodosum leprosum in lepromatous leprosy, cutaneous lupus erythematosus, severe aphtosis), cancers (relapsed/refractory multiple myeloma) and inflammatory conditions. Several side effects are associated with thalidomide: teratogenicity, peripheral neuropathy and deep venous thrombosis; some are minor, such as somnolence or abdominal pain and endocrinologic disturbances. Use of thalidomide is strictly controlled with close adherence to a birth control program and close monitoring for early development of peripheral neuropathy.
Laffitte
Emmanuel
E
Service de dermatologie et vénérologie, CHUV, 1011 Lausanne. emmanuel.laffitte@hospvd.ch
D006801:Humans; D012871:Skin Diseases / Q000188:drug therapy; D013792:Thalidomide / Q000627:therapeutic use*
D013792:Thalidomide