Membrane targeting of endocytic adaptors: cargo and lipid do it together.
The adaptor complex AP-2 plays an important role in cargo selection and clathrin lattice formation during clathrin-mediated endocytosis. In a recent issue of Molecular Cell, Honing et al. demonstrate that high-affinity AP-2 membrane association is achieved through a combination of low-affinity interactions with membrane phosphoinositides and cargo proteins, regulated by phosphorylation.
Gaidarov
Ibragim
I
Arena Pharmaceuticals, San Diego, California 92121, USA.
Keen
James H
JH
D033962:Adaptor Protein Complex 2 / Q000502:physiology*; D000818:Animals; D002966:Clathrin / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology*; D050356:Lipid Metabolism; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D021381:Protein Transport
D033962:Adaptor Protein Complex 2; D002966:Clathrin; D010744:Phosphoric Monoester Hydrolases