[Study of the relationship between cardiovascular risk factors and severity of coronary artery disease in patients underwent coronary angiography].
OBJECTIVE
To evaluate the correlation between multiple cardiovascular risk factors and the extent and severity of angiographic coronary artery disease (CAD) in patients underwent coronary angiography.


METHODS
Nine hundred and twenty consecutive patients underwent coronary angiography were selected according to inclusion criteria. The extent and severity of angiographic CAD was diagnosed by: (1) whether or not CAD was diagnosed by angiography; (2) the number of diseased vessels; (3) The CAD Gensini cumulative index. Cardiovascular risk factors included were age, gender, hypertension, smoking status, type 2 diabetes mellitus, dyslipidemia, and high uric acid level. Analyses were achieved by univariate and multivariate analysis.


RESULTS
(1) Logistic regression analysis showed that high low-density lipoprotein was a prominent predictor of the extent and severity of angiographic CAD (OR = 2.816, 95% CI 1.903 - 4.167, P = 0.001). (2) High low-density lipoprotein was the most important risk factor in men, whereas smoking and high uric acid were the most important risk factors in women.


CONCLUSIONS
(1) It is very important to control risk factors in the intervention and prevention of CAD. (2) Distribution of risk factors and their severities vary in different genders, therefore the treatment of risk factors should be done differently.
Guo
Yong-he
YH
Department of Cardiology, Beijing Anzhen Hospital, Capital University of Medical Science, Beijing 100029, China.
Zhang
Wei-jun
WJ
Zhou
Yu-jie
YJ
Zhao
Dong
D
Zhou
Zhi-ming
ZM
Zhang
Hong
H
D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000209:etiology*; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors