[The expression of TRAIL, TRAIL-R (DR4, DcR1) and Fas-L in patients with ovarian cancer].
OBJECTIVE
To investigate the apoptosis induced by TRAIL, TRAIL-R and Fas-L in patients


METHODS
The expression of TRAIL, TRAIL-R (DR4,DcR1) and Fas-L in ovarian cancer was detected with immunohistochemistry.


RESULTS
The levels of DR4 and DcR1 expression in ovarian carcinoma with ovarian carcinoma were lower than that of normal tissues. The positive rate of DR4 in well-differentiated ovarian carcinoma was significantly higher than that in poorly differentiated ovarian carcinoma (92.31% vs 54.55%, P < 0.05). The expression of TRAIL was significantly correlated with that of Fas-L (r = 0.777).


CONCLUSIONS
The expressions of DR4 and DcR1 are lower than that of normal tissues, and the expression of DR4 might be a prognostic factor in ovarian cancer.
Li
Chun-mei
CM
Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Peng
Zhi-lan
ZL
Yang
Kai-xuan
KX
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D051017:Apoptosis Regulatory Proteins / Q000096:biosynthesis* / Q000235:genetics; D053222:Fas Ligand Protein; D005260:Female; D006801:Humans; D008562:Membrane Glycoproteins / Q000096:biosynthesis* / Q000235:genetics; D051379:Mice; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D018124:Receptors, Tumor Necrosis Factor / Q000096:biosynthesis* / Q000235:genetics; D053221:TNF-Related Apoptosis-Inducing Ligand; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis* / Q000235:genetics; D048069:Tumor Necrosis Factors / Q000096:biosynthesis* / Q000235:genetics
D051017:Apoptosis Regulatory Proteins; C505661:FASLG protein, human; D053222:Fas Ligand Protein; C505658:Fasl protein, mouse; D008562:Membrane Glycoproteins; D012333:RNA, Messenger; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D018124:Receptors, Tumor Necrosis Factor; D053221:TNF-Related Apoptosis-Inducing Ligand; C105190:TNFRSF10A protein, human; C505653:TNFSF10 protein, human; C505654:Tnfsf10 protein, mouse; D014409:Tumor Necrosis Factor-alpha; D048069:Tumor Necrosis Factors