Analogues of the styrylquinoline and styrylquinazoline HIV-1 integrase inhibitors: design and synthetic problems.
In our work, leading to new styrylquinoline and styrylquinazoline inhibitors of HIV integrase, we analyzed virtual combinatorial library that includes these compounds. Using this method we were able to find interesting synthetic targets. We optimized synthetic procedure yielding such compounds and obtained a couple of new analogues. Their activity will be evaluated in the near future.
Polański
J
J
Department of Organic Chemistry, Institute of Chemistry, University of Silesia, PL 40-006 Katowice, Poland. polanski@us.edu.pl
Niedbała
H
H
Musioł
R
R
Tabak
D
D
Podeszwa
B
B
Gieleciak
R
R
Bak
A
A
Pałka
A
A
Magdziarz
T
T
D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D019428:HIV Integrase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D007202:Indicators and Reagents; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology*
D019428:HIV Integrase Inhibitors; D007202:Indicators and Reagents; D011799:Quinazolines; D011804:Quinolines; C501448:styrylquinazoline; C481600:styrylquinoline