title: Complexation of fluoxetine hydrochloride with beta-cyclodextrin. A proton magnetic resonance study in aqueous solution.
abstract: A proton magnetic resonance spectroscopic study in D2O of mixtures of fluoxetine hydrochloride (guest) with beta-cyclodextrin (host) revealed the existence of two different equilibria for 1:1 inclusion complexes in which -CF3 substituted ring of the guest is more tightly held by the host cavity. The structures of the two complexes have been proposed which are supported by 2DROESY spectral data. The dissociation constant was also determined.
authors.affiliation: Department of Chemistry, Aligarh Muslim University, Aligarh 202002, UP, India. smashhoodali@yahoo.com
authors.forename: Syed Mashhood
authors.initials: SM
authors.lastname: Ali
authors.forename: Fahmeena
authors.initials: F
authors.lastname: Asmat
authors.forename: Arti
authors.initials: A
authors.lastname: Maheshwari
authors.forename: Mamoru
authors.initials: M
authors.lastname: Koketsu
mesh_terms: D002614:Chelating Agents / Q000032:analysis* / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D005473:Fluoxetine / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D012996:Solutions / Q000032:analysis / Q000737:chemistry; D014867:Water / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D002614:Chelating Agents; D012996:Solutions; D047392:beta-Cyclodextrins; D005473:Fluoxetine; D014867:Water