title: In vivo determination of the optical properties of infant brain using frequency-domain near-infrared spectroscopy.
abstract: We investigate the optical properties of the brain in 23 neonates in vivo using a frequency domain near-infrared spectroscopy (NIRS). In this study, a calibration procedure is employed to determine the absorption and reduced scattering coefficients with single source-detector separation. The absorption coefficients of the infant foreheads are lower than the values reported in adults. A large intersubject variation in the reduced scattering coefficients is also demonstrated. Furthermore, physiological parameters are derived from the absorption coefficients at two wavelengths (788 and 832 nm). The mean total hemoglobin concentration (THC) is 39.7+/-9.8 microM and the mean cerebral blood oxygen saturation (StO2) is 58.7+/-11.2%. Our preliminary results show that this bedside frequent domain NIRS could provide quantitative optical measurement of the infant brain.
authors.affiliation: Tsinghua University, Department of Biomedical Engineering, Beijing 100084, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.forename: Hai Shu
authors.initials: HS
authors.lastname: Ding
authors.forename: Xin Lin
authors.initials: XL
authors.lastname: Hou
authors.forename: Cong Le
authors.initials: CL
authors.lastname: Zhou
authors.forename: Britton
authors.initials: B
authors.lastname: Chance
mesh_terms: D000042:Absorption; D001921:Brain / Q000528:radiation effects*; D006801:Humans; D007231:Infant, Newborn; D008027:Light; D008954:Models, Biological; D015203:Reproducibility of Results; D019265:Spectroscopy, Near-Infrared