title: Meningeal melanocytoma associated with ipsilateral nevus of Ota presenting as intracerebral hemorrhage: case report.
abstract: OBJECTIVE
  The authors report a rare case of meningeal melanocytoma presenting with unconsciousness, which was caused by an intracerebral hematoma and associated with a history of ipsilateral nevus of Ota.
  
  
  METHODS
  A 75-year-old woman developed nevus of Ota in the first and second divisions of the right trigeminal nerve territory, which had been treated with a skin graft 40 years earlier. She noticed right exophthalmos but left it untreated for 2 years and then became comatose owing to orbital and intracranial tumors, the latter manifesting with hemorrhage.
  
  
  METHODS
  She underwent craniotomy, during which the tumor was partially removed with intracerebral hematoma. Histopathologically, the tumor was diagnosed as meningeal melanocytoma. Western blot analysis demonstrated a retained protein expression of cell cycle inhibitor p16(INK4A) and a high level of antiapoptotic Bcl-2 in the resected tumor.
  
  
  CONCLUSIONS
  The combination of nevus of Ota and meningeal melanocytoma has been reported in only four cases in the literature, including the current case. This is the first case coinciding with intracerebral hemorrhage, suggesting the necessity for careful follow-up with radiological images.
authors.affiliation: Department of Neurosurgery, Kyorin University School of Medicine, Tokyo, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Hino
authors.forename: Motoo
authors.initials: M
authors.lastname: Nagane
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Fujioka
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Shiokawa
mesh_terms: D000368:Aged; D002543:Cerebral Hemorrhage / Q000209:etiology* / Q000601:surgery; D003390:Cranial Nerve Neoplasms / Q000150:complications* / Q000601:surgery; D003399:Craniotomy / Q000379:methods; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008545:Melanoma / Q000150:complications*; D009507:Nevus of Ota / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D020433:Trigeminal Nerve Diseases / Q000150:complications* / Q000601:surgery