Effects of cochlear implant use on the electrically evoked middle latency response in children.
The electrically evoked middle latency response (eMLR) reflects central auditory activity in cochlear implant users. This response was recorded repeatedly in 50 children over the first year of cochlear implant use and in 31 children with 5.3+/-2.9 years of implant experience. The eMLR was rarely detected at the time of implantation in anaesthetized or sedated children and was detected in only 35% of awake children at initial device stimulation. The detectability of the eMLR increased over the first year of implant use becoming 100% detectable in children after at least one year. Acutely evoked responses were more likely to be present in older children despite longer periods of auditory deprivation. Within six months of implant use, most children had detectable eMLRs. At early stages of device use, eMLR amplitudes were lower in children implanted below the age of 5 years compared to children implanted at older ages; amplitudes increased over time in both groups. Latencies after six months of implant use were prolonged in the younger group and decreased with implant use. EMLR changes with chronic cochlear implant use suggest an activity-dependent plasticity of the central auditory system. Results suggest that the pattern of electrically evoked activity and development in the auditory thalamocortical pathways will be dependent upon the duration of auditory deprivation occurring in early childhood.
Gordon
Karen A
KA
Department of Otolaryngology, The Hospital for Sick Children, University of Toronto, Toronto, Ont., Canada M5G 1X8. karen.gordon@utoronto.ca
Papsin
Blake C
BC
Harrison
Robert V
RV
D000293:Adolescent; D000704:Analysis of Variance; D001303:Auditory Cortex / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D003054:Cochlear Implants; D003430:Cross-Sectional Studies; D003638:Deafness / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D004558:Electric Stimulation; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D013788:Thalamus / Q000502:physiology