Electrochemical study of breast cancer cells MCF-7 and its application in evaluating the effect of diosgenin.
The electrochemical behavior of breast cancer cells was studied on a graphite electrode by cyclic voltammetry (CV) and potentiometric stripping analysis (PSA). In both cases, only one oxidative peak at approximately +0.75 V was observed. The peak area in PSA was used to study the growth of the cells and the effect of diosgenin on MCF-7 cells. The results showed that diosgenin can effectively inhibit the viability and proliferation of the breast cancer cells.
Li
Jia
J
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P R. China.
Liu
Xuanmin
X
Guo
Manli
M
Liu
Yingju
Y
Liu
Shanchao
S
Yao
Shouzhuo
S
D000970:Antineoplastic Agents / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000737:chemistry* / Q000188:drug therapy*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D004144:Diosgenin / Q000494:pharmacology*; D004563:Electrochemistry; D005260:Female; D006801:Humans; D007202:Indicators and Reagents; D011199:Potentiometry; D014343:Trypan Blue
D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D014343:Trypan Blue; D004144:Diosgenin