title: Cerebral glucose metabolism associated with a fear network in panic disorder.
abstract: The present study was performed to assess cerebral glucose metabolism in patients with panic disorder using positron emission tomography. F-fluorodeoxyglucose positron emission tomography with voxel-based analysis was used to compare regional brain glucose utilization in 12 nonmedicated panic disorder patients, without their experiencing panic attacks during positron emission tomography acquisition, with that in 22 healthy controls. Panic disorder patients showed appreciably high state anxiety before scanning, and exhibited significantly higher levels of glucose uptake in the bilateral amygdala, hippocampus, and thalamus, and in the midbrain, caudal pons, medulla, and cerebellum than controls. These results provided the first functional neuroimaging support in human patients for the neuroanatomical hypothesis of panic disorder focusing on the amygdala-based fear network.
authors.affiliation: Department of Psychosomatic Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655. yosakai-tky@umin.ac.jp
authors.forename: Yojiro
authors.initials: Y
authors.lastname: Sakai
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kumano
authors.forename: Masami
authors.initials: M
authors.lastname: Nishikawa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Sakano
authors.forename: Hisanobu
authors.initials: H
authors.lastname: Kaiya
authors.forename: Etsuko
authors.initials: E
authors.lastname: Imabayashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Ohnishi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsuda
authors.forename: Asako
authors.initials: A
authors.lastname: Yasuda
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sato
authors.forename: Mirko
authors.initials: M
authors.lastname: Diksic
authors.forename: Tomifusa
authors.initials: T
authors.lastname: Kuboki
mesh_terms: D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000378:metabolism*; D002560:Cerebrovascular Circulation; D005239:Fear; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D009415:Nerve Net / Q000000981:diagnostic imaging / Q000378:metabolism*; D016584:Panic Disorder / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000523:psychology; D049268:Positron-Emission Tomography / Q000379:methods
chemical_list: D019788:Fluorodeoxyglucose F18; D005947:Glucose