title: DNA damaging activities of methanol extract of Ajuga postii and iridoid glucoside reptoside.
abstract: An iridoid glucoside reptoside (1) has been isolated as a DNA damaging active agent by bioassay-guided fractionation of the methanol extract of Ajuga postii. Furthermore, from the acetone extract of A. postii two known triterpenic compounds ursolic acid, alpha-amyrin and two steroidal compounds (24S)-24-ethylcholesta-5,25-dien-3beta-ol and beta-sitosterol were isolated. Their structures were elucidated based on 1D and 2D NMR techniques and mass data.
authors.affiliation: TUBITAK, Ulusal Metroloji Enstitüsü, Group of Chemistry, PO Box 54, 41470, Gebze-Kocaeli, Turkey. ahmet.goren@ume.tubitak.gov.tr
authors.forename: Ahmet C
authors.initials: AC
authors.lastname: Gören
authors.forename: Bing-Nan
authors.initials: BN
authors.lastname: Zhou
authors.forename: Gülaçti
authors.initials: G
authors.lastname: Topçu
authors.forename: Gamze
authors.initials: G
authors.lastname: Kökdil
authors.forename: David G I
authors.initials: DG
authors.lastname: Kingston
mesh_terms: D031328:Ajuga / Q000737:chemistry*; D004249:DNA Damage; D039823:Iridoids / Q000737:chemistry* / Q000633:toxicity; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000737:chemistry; D010936:Plant Extracts / Q000633:toxicity; D012855:Sitosterols / Q000737:chemistry; D013261:Sterols / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry; D000097245:Ursolic Acid
chemical_list: D039823:Iridoids; D009828:Oleanolic Acid; D010936:Plant Extracts; D012855:Sitosterols; D013261:Sterols; D014315:Triterpenes; D000097245:Ursolic Acid; C503474:(24S)-24-ethylcholesta-5,25-dien-3beta-ol; C503473:reptoside; C025473:gamma-sitosterol; C036380:beta-amyrin