A cross-reactive tick cement antigen is a candidate broad-spectrum tick vaccine.
Truncated constructs of 64P (64TRPs), a secreted cement protein from salivary glands of the tick Rhipicephalus appendiculatus, provided cross-protection against Rhipicephalus sanguineus and Ixodes ricinus, apparently by targeting antigens in the midgut and salivary glands of adults and nymphs, causing mortality. Tick feeding on 64TRP-immunised animals stimulated local inflammatory immune responses (involving basophils, eosinophils, lymphocytes, mast cells, macrophages and dendritic-like cells) that boosted the immune status of vaccinated animals. The vaccine trial results, and antigenic cross-reactivity of 64TRPs with R. sanguineus, I. ricinus, Amblyomma variegatum and Boophilus microplus, indicate the potential of 64TRPs as a broad-spectrum anti-tick vaccine.
Trimnell
Adama R
AR
Seattle Biomedical Research Institute, WA 98109-5219, USA.
Davies
Gillian M
GM
Lissina
Olga
O
Hails
Rosie S
RS
Nuttall
Patricia A
PA
D000818:Animals; D000941:Antigens / Q000276:immunology*; D006224:Cricetinae; D003429:Cross Reactions; D006168:Guinea Pigs; D007114:Immunization; D012867:Skin / Q000473:pathology; D013984:Tick Infestations / Q000473:pathology / Q000517:prevention & control*; D013987:Ticks / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology*
D000941:Antigens; D014614:Vaccines, Synthetic