title: [HLA-DRB1 alleles and rheumatoid arthritis in northern Italy: lack of correlation with disease severity and extra-articular manifestations].
abstract: We studied HLA-DRB1 alleles in 101 patients with rheumatoid arthritis (RA) and 229 normal subjects by polymerase chain reaction and sequence-specific oligonuclotide hybridization. We observed a statistically significant association between HLA-DR4 and RA (p = 0,0088). This association was not observed for the DR1 status. No particular DR4 suballeles were preferentially expressed in patients. Allele *0102 was more frequent in RA patients (p = 0.0084), while *0103 in controls (p = 0.000047). No difference was observed for the presence of early erosions and extra-articular features in patients with no, one or two RA associated alleles and among share epitope positive and negative patients.
authors.affiliation: Sezione di Medicina Interna, Dipartimento di Medicina Clinica e Sperimentale, Policlinico G.B. Rossi, Universita di Verona.
authors.forename: Ruggero
authors.initials: R
authors.lastname: Beri
authors.forename: Dimitri
authors.initials: D
authors.lastname: Peterlana
authors.forename: Antonio
authors.initials: A
authors.lastname: Puccetti
authors.forename: Sara
authors.initials: S
authors.lastname: Simeoni
authors.forename: Paolo
authors.initials: P
authors.lastname: Garzotti
authors.forename: Domenico
authors.initials: D
authors.lastname: Biasi
authors.forename: Paola
authors.initials: P
authors.lastname: Caramaschi
authors.forename: Elisa
authors.initials: E
authors.lastname: Tinazzi
authors.forename: Claudio
authors.initials: C
authors.lastname: Lunardi
mesh_terms: D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000235:genetics*; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains