The increase in serum uric acid concentration caused by diuretics might be beneficial in heart failure.
Patients with mild-moderate chronic heart failure (CHF) often have raised levels of serum uric acid (UA). This is due, amongst other factors, to reduced UA excretion by the kidneys, which is partly explained by restriction of sodium intake and treatment with diuretics. The decline in renal function that parallels worsening cardiac function also contributes to elevated serum UA in patients with advanced CHF. However, UA production also appears to be augmented in CHF. Because UA scavenges various reactive oxygen species, diuretic-induced elevations in serum UA could be beneficial in patients with CHF. This concept is supported by the superior performance of antihypertensive therapy with diuretics in preventing heart failure. The present hypothesis may be tested by examining the effects of add-on treatment with a thiazide-type diuretic on morbidity and mortality, or surrogate variables, in asymptomatic patients with left ventricular dysfunction but without fluid retention.
Reyes
Ariel J
AJ
Institute of Cardiovascular Theory, Sotelo 3908, 11700 Montevideo, Uruguay. ajreyes@internet.com.uy
D000493:Allopurinol / Q000494:pharmacology; D004232:Diuretics / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000494:pharmacology; D006333:Heart Failure / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D014527:Uric Acid / Q000097:blood*
D004232:Diuretics; D016166:Free Radical Scavengers; D014527:Uric Acid; D000493:Allopurinol