title: [Effect of glycine and strychnine on Cl(-)-activated Mg2+-ATPase from bream brain microsomes (Abamis brama L.)].
abstract: The effect of glycine and strychnine on Mg2+-ATPase from the microsomal fraction of the bream (Abramis brama L.) brain was studied. The glycine in the concentration range 10(-7)-10(-4) M activates the enzyme. The effect of glycine on Mg2+-ATPase is obviated by 100 microM strychnine. The strychnine in the concentration range 5-90 microM activates the basal Mg2+-ATPase but decreases the effect of the enzyme activation by 10(-4) M glycine. The effect of Cl- on Mg2+-ATPase depends on the substrate concentration (Mg2+-ATP) and is not observed in the presence of 100 microM strychnine. A receptor-dependent pathway of glycine and strychnine action on Cl(-)-activated Mg2+-ATPase from bream brain microsomes is proposed.
authors.forename: S A
authors.initials: SA
authors.lastname: Menzikov
authors.forename: O V
authors.initials: OV
authors.lastname: Menzikova
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D027321:Anion Transport Proteins; D001921:Brain / Q000166:cytology; D005399:Fishes / Q000378:metabolism*; D005998:Glycine / Q000494:pharmacology*; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology*; D013331:Strychnine / Q000494:pharmacology*
chemical_list: D027321:Anion Transport Proteins; D000251:Adenosine Triphosphatases; C031652:anion-sensitive ATPases; D013331:Strychnine; D005998:Glycine