[The significance and expression of EGF and its receptor in nasal inverted papillomas and the correlation with malignant phenotype].
OBJECTIVE
To determine the expression of epidermal growth factor (EGF) and its receptor in nasal inverted papillomas (NIP) and to clarify the function of EGF in the establishment of NIPs and the correlation with malignant phenotype.


METHODS
The expression of EGF and its receptor EGFR were examined by immunohistochemistry using LSAB method in sections of NIP from 24 patients and squamous carcinoma from 4 patients.


RESULTS
Showed that all the epithelium in NIPs together with vascular and stroma adjacent to the epithelium, expressed different degree of EGF. The EGF, EGFR expression in epithelium was significantly stronger in severe atypical hyperplasia of NIP than that in mild atypical hyperplasia of NIP (P < 0.01).


CONCLUSIONS
The results suggest that EGF, EGFR participate in the growth of NIPs, part of which shows the characteristics of containing plenty of blood vessels and being bloody in operation. The enhanted EGF, EGFR in the epithelium may be identified as one of the parameters of judging the propensity of NIPs malignant transformation.
Kong
Hui
H
Department of Otorhinolaryngology, the Second Affiliated Hospital of Dalian Medical University, Dalian, 116023, China. konghui6905@163.com
Sun
Xiuzhen
X
Wu
Xu
X
Guan
Qingjie
Q
Zou
Chunxia
C
D000368:Aged; D004815:Epidermal Growth Factor / Q000096:biosynthesis*; D066246:ErbB Receptors / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000378:metabolism / Q000473:pathology*; D018308:Papilloma, Inverted / Q000378:metabolism / Q000473:pathology*
D004815:Epidermal Growth Factor; D066246:ErbB Receptors