title: Association of multiple DRD2 polymorphisms with anorexia nervosa.
abstract: To investigate whether the dopaminergic system plays a role in the etiology of anorexia nervosa (AN) via the dopamine D2 receptor, we investigated association and transmission disequilibrium at seven single-nucleotide polymorphisms (SNPs) spanning about 75 kbp of the gene DRD2. We studied 191 probands with a DSM-IV diagnosis of AN, 457 parents and affected relatives with a DSM-IV eating disorder diagnosis, and 98 unrelated, female, normal weight controls. The -141 C/- insertion/deletion (-141 Indel), previously shown to affect DRD2 transcription efficiency, and multiple exon seven polymorphisms, one of which has previously been shown to affect DRD2 transcript stability, exhibited statistically significant association with diagnosis in haplotype transmission disequilibrium and in haplotype case : control analyses. Significant linkage disequilibrium between the -141 Indel and two exon seven SNPs (939Y and 957Y) was observed over a distance of >50 kbp in the AN probands but not in the controls. Genetically transmitted variation in D2 dopamine receptor expression mediated by functional polymorphisms affecting transcription and translation efficiency may play a role in vulnerability to AN.
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7236, USA. bergena@mail.nih.gov
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Bergen
authors.forename: Meredith
authors.initials: M
authors.lastname: Yeager
authors.forename: Robert A
authors.initials: RA
authors.lastname: Welch
authors.forename: Kashif
authors.initials: K
authors.lastname: Haque
authors.forename: J Kelly
authors.initials: JK
authors.lastname: Ganjei
authors.forename: Marianne B M
authors.initials: MB
authors.lastname: van den Bree
authors.forename: Chiara
authors.initials: C
authors.lastname: Mazzanti
authors.forename: Irma
authors.initials: I
authors.lastname: Nardi
authors.forename: Manfred M
authors.initials: MM
authors.lastname: Fichter
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Halmi
authors.forename: Allan S
authors.initials: AS
authors.lastname: Kaplan
authors.forename: Michael
authors.initials: M
authors.lastname: Strober
authors.forename: Janet
authors.initials: J
authors.lastname: Treasure
authors.forename: D Blake
authors.initials: DB
authors.lastname: Woodside
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Bulik
authors.forename: Silviu-Alin
authors.initials: SA
authors.lastname: Bacanu
authors.forename: Bernie
authors.initials: B
authors.lastname: Devlin
authors.forename: Wade H
authors.initials: WH
authors.lastname: Berrettini
authors.forename: David
authors.initials: D
authors.lastname: Goldman
authors.forename: Walter H
authors.initials: WH
authors.lastname: Kaye
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000856:Anorexia Nervosa / Q000235:genetics*; D016009:Chi-Square Distribution; D005091:Exons; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics*
chemical_list: D017448:Receptors, Dopamine D2