title: Successful hormone treatment of orbital leiomyoma.
abstract: OBJECTIVE
  To describe the successful hormone treatment of noncircumscribed orbital leiomyoma.
  
  
  METHODS
  Case report.
  
  
  METHODS
  A 66-year-old woman with histologically proven orbital leiomyoma.
  
  
  METHODS
  Because surgical excision of the tumor was impossible, therapy with the gonadotropin-releasing hormone (GnRH) analog goserelin was performed.
  
  
  RESULTS
  Hormone treatment was well tolerated and no side effects were noted. The tumor regressed significantly during treatment. No recurrence occurred during a 5-year follow-up period.
  
  
  CONCLUSIONS
  This report describes for the first time successful hormone treatment of a noncircumscribed orbital leiomyoma. Goserelin may have an antiproliferative effect on leiomyoma cells via membrane receptors for GnRH.
authors.affiliation: Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Wrede
authors.forename: Burkhard
authors.initials: B
authors.lastname: Helmke
authors.forename: Marius
authors.initials: M
authors.lastname: Hartmann
authors.forename: Hans E
authors.initials: HE
authors.lastname: Voelcker
authors.forename: Stefan
authors.initials: S
authors.lastname: Dithmar
mesh_terms: D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D017273:Goserelin / Q000627:therapeutic use*; D006801:Humans; D007889:Leiomyoma / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D009918:Orbital Neoplasms / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology
chemical_list: D018931:Antineoplastic Agents, Hormonal; D014408:Biomarkers, Tumor; D017273:Goserelin