Preparation and characterization of a novel pH-sensitive ion exchange resin.
Methylacrylic acid/styrene cross-linked with divinylbenzene is a novel pH-sensitive ion exchange resin. Microspheres of this resin were characterized by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The microspheres showed a pulsatile swelling behavior when the pH of the media changed. The pH-sensitive microspheres were loaded with salbutamol sulfate and the drug-release characteristics were studied under both simulated gastric and intestinal pH conditions. The results obtained showed that the drug release also depended on the pH of the release media.
Liu
Hongfei
H
Department of Pharmaceutics, Shen yang Pharmaceutical University, Shen yang 110016, People's Republic of China. liuhongfei1979@sohu.com
Zhang
Shu
S
Nie
Shufang
S
Zhao
Xin
X
Sun
Xiyang
X
Yang
Xingang
X
Pan
Weisan
W
D006863:Hydrogen-Ion Concentration; D007474:Ion Exchange; D007475:Ion Exchange Resins / Q000032:analysis* / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D010316:Particle Size
D007475:Ion Exchange Resins