title: TRP channels in mechanosensation.
abstract: Channels of the TRP superfamily have sensory roles in a wide variety of receptor cells, especially in mechanosensation. In some cases, the channels appear to be directly activated by mechanical force; in others, they appear to be downstream of a messenger pathway initiated by force on a non-channel sensor. A remaining challenge for most of these mechanosensory TRPs is to clarify the specific mechanism of activation.
authors.affiliation: Howard Hughes Medical Institute and Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
authors.forename: Shuh-Yow
authors.initials: SY
authors.lastname: Lin
authors.forename: David P
authors.initials: DP
authors.lastname: Corey
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D008465:Mechanoreceptors / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D050052:TRPC Cation Channels
chemical_list: D015220:Calcium Channels; D050052:TRPC Cation Channels