Multiple roles of arginine/serine-rich splicing factors in RNA processing.
SR proteins (serine- and arginine-rich proteins) are an evolutionarily conserved family consisting of essential pre-mRNA splicing factors. Since their discovery and initial characterization, roles of SR proteins in pre-mRNA splicing and in subsequent steps of post-transcriptional gene expression have expanded significantly. The current hypotheses suggest that SR proteins are multifunctional adaptor molecules that may couple distinct steps of RNA metabolism. In the present study, we will provide an overview of the roles of SR proteins in different steps of post-transcriptional gene expression.
Sanford
J R
JR
MRC Human Genetics Unit, Edinburgh EH4 2XU, Scotland, U.K.
Ellis
J
J
Cáceres
J F
JF
D001120:Arginine / Q000378:metabolism*; D006801:Humans; D012326:RNA Splicing; D016601:RNA-Binding Proteins / Q000737:chemistry* / Q000145:classification / Q000378:metabolism*; D012694:Serine / Q000378:metabolism*; D017381:Spliceosomes / Q000235:genetics / Q000378:metabolism
D016601:RNA-Binding Proteins; D012694:Serine; D001120:Arginine