Plocoralides A-C, polyhalogenated monoterpenes from the marine alga Plocamium corallorhiza.
Three new polyhalogenated monoterpenes, plocoralides A-C (1-3) along with three known compounds (4-6) have been isolated from the organic extract of the red alga P. corallorhiza. Structures of the new compounds were characterized as 4,8-dibromo-1,1-dichloro-3,7-dimethyl-2E,6E-octadiene (1), 4,6-dibromo-1,1-dichloro-3,7-dimethyl-2E,7-octadiene (2) and 4,8-dibromo-1,1,7-trichloro-3,7-dimethyl-2E,5Z-octadiene (3) on the basis of one- and two-dimensional NMR spectroscopic data and MS analyses. Compounds 2-6 show moderate cytotoxicity toward esophageal cancer cells.
Knott
Michael G
MG
Faculty of Pharmacy, Rhodes University, Artillery Road, Grahamstown, 6140, South Africa.
Mkwananzi
Henry
H
Arendse
Catherine E
CE
Hendricks
Denver T
DT
Bolton
John J
JJ
Beukes
Denzil R
DR
D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D006846:Hydrocarbons, Halogenated / Q000302:isolation & purification; D015394:Molecular Structure; D039821:Monoterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D044725:Plocamium / Q000737:chemistry*
C502877:4,6-dibromo-1,1-dichloro-3,7-dimethyl-2E,7-octadiene; C502878:4,8-dibromo-1,1,7-trichloro-3,7-dimethyl-2E,5Z-octadiene; C502876:4,8-dibromo-1,1-dichloro-3,7-dimethyl-2E,6E-octadiene; D000970:Antineoplastic Agents; D006846:Hydrocarbons, Halogenated; D039821:Monoterpenes