Long-term effects of acute and of chronic hypoxia on behavior and on hippocampal histology in the developing brain.
Ten-day-old rat pups (P10) subjected to acute hypoxia (down to 4% O2) had as adults increased aggression (handling test), memory impairment (water maze test), and decreased CA1 cell counts. Pups subjected to chronic hypoxia (10% O2 from P0 to P21) had increased aggression, hyperactivity (open-field test), and decreased CA1 cell counts. Chronic hypoxia with superimposed acute hypoxia resulted in consequences that were not different from those of chronic hypoxia.
Mikati
Mohamad A
MA
Adult and Pediatric Epilepsy Program, Department of Pediatrics, PO Box 11-0236/B52 Riad el Solh, American University of Beirut, Beirut 1107-2020, Lebanon. mamikati@aub.edu.lb
Zeinieh
Michele P
MP
Kurdi
Rana M
RM
Harb
Samer A
SA
El Hokayem
Jimmy A
JA
Daderian
Rita H
RH
Shamseddine
Alhan
A
Obeid
Makram
M
Bitar
Fadi F
FF
El Sabban
Marwan
M
D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000502:physiology*; D002452:Cell Count / Q000379:methods; D016923:Cell Death / Q000502:physiology; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D004921:Erythropoietin / Q000097:blood; D005106:Exploratory Behavior / Q000502:physiology; D006624:Hippocampus / Q000254:growth & development / Q000473:pathology / Q000503:physiopathology; D000860:Hypoxia / Q000097:blood / Q000473:pathology* / Q000503:physiopathology*; D020287:In Situ Nick-End Labeling / Q000379:methods; D018782:Maze Learning / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013995:Time; D013997:Time Factors
D004921:Erythropoietin