Towards a quantitative understanding of horizontal gene transfer: a kinetic model.
In this work, we present a simple kinetic model of horizontal gene transfer. It describes the processes of gene duplication, mutation, gene transfer and the regulation of the total size of the genome for genetically homogeneous prokaryotic species or strains. The emerging nonlinear system of first-order differential equations can be linearized at the stationary point. For selected models, we give an analytical solution for the number of foreign and native genes within a species. We identify a regime characterized by a fast gene transfer rate and species with a mixed genome, a slow gene transfer regime with pure organisms, and a crossover region. The data are compared to experiments, and the biological implications of our model are discussed.
Koslowski
Thorsten
T
Institut für Physikalische Chemie, Universität Freiburg, Albertstrasse 23a, D-79104 Freiburg im Breisgau, Germany. thorsten.koslowski@physchem.uni-freiburg.de
Zehender
Fabian
F
D000818:Animals; D001105:Archaea / Q000235:genetics; D002463:Cell Membrane Permeability; D000458:Cyanobacteria / Q000235:genetics; D005057:Eukaryotic Cells / Q000502:physiology; D020440:Gene Duplication; D022761:Gene Transfer, Horizontal; D016680:Genome, Bacterial; D008957:Models, Genetic; D009154:Mutation; D013559:Symbiosis