Manipulating dendritic cells to induce regulatory T cells.
Dendritic cells (DCs) induce and regulate T-cell responses, and tolerogenic DCs can promote the development of regulatory T cells with suppressive activity. The possibility of manipulating DCs using different pharmacological or biological agents, enabling them to exert tolerogenic activities, could be exploited to better control a variety of chronic inflammatory conditions, from autoimmune diseases to allograft rejection.
Penna
G
G
BioXell, Milan, Italy.
Giarratana
N
N
Amuchastegui
S
S
Mariani
R
R
Daniel
K C
KC
Adorini
L
L
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D003713:Dendritic Cells / Q000187:drug effects / Q000502:physiology*; D006084:Graft Rejection / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008213:Lymphocyte Activation; D018167:Receptors, Calcitriol / Q000819:agonists; D011956:Receptors, Cell Surface / Q000378:metabolism; D013601:T-Lymphocytes / Q000502:physiology*
D007166:Immunosuppressive Agents; D018167:Receptors, Calcitriol; D011956:Receptors, Cell Surface