Enantioselective syn-selective scandium-catalyzed ene reactions.
An enantio- and diastereoselective carbonyl-ene reaction catalyzed by chiral scandium pyridyl bis(oxazoline) (pybox) complexes has been developed. Uniformly high enantiomeric excesses and good yields were observed. Use of trisubstituted olefins generated the syn product in high enantio- and diastereoselectivity.
Evans
David A
DA
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA. evans@chemistry.harvard.edu
Wu
Jimmy
J
D000475:Alkenes / Q000737:chemistry*; D000577:Amides / Q000737:chemistry; D002384:Catalysis; D006038:Glyoxylates / Q000737:chemistry*; D012538:Scandium / Q000737:chemistry*; D013237:Stereoisomerism; D013453:Sulfonylurea Compounds / Q000737:chemistry
D000475:Alkenes; D000577:Amides; D006038:Glyoxylates; D013453:Sulfonylurea Compounds; C032160:glyoxamide; D012538:Scandium