Prevalence of strongyloides in Northern Thailand and treatment with ivermectin vs albendazole.
The stools of 697 cases were examined by agar plate technique at Tambon Makam Luang, Sun Pa Tong district, Chiang Mai; there were Strongyloides stercoralis 15.9%,Opisthorchis viverrini 5.1%, intestinal fluke 0.1%. Treatment with ivermectin 78 cases and albendazole 33 cases of strongyloidiasis gave cure rates at 98.7% and 78.7%, respectively. Alkaline phosphatase in some patients were increased at mild level after treatment. Side effects in ivermectin group were anorexia, nausia, diarrhea, diffuse itching and drowsiness; and in albendazole group were nausia and diarrhea. The efficacy of single dose and mild side effects suggest ivermectin as drug of choice for strongyloidiasis treatment.
Nontasut
Ponganant
P
Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Muennoo
Chatree
C
Sa-nguankiat
Surapol
S
Fongsri
Sutep
S
Vichit
Adulsak
A
D015766:Albendazole / Q000009:adverse effects / Q000627:therapeutic use*; D000818:Animals; D000871:Anthelmintics / Q000009:adverse effects / Q000627:therapeutic use*; D005243:Feces / Q000469:parasitology; D005260:Female; D006801:Humans; D007559:Ivermectin / Q000009:adverse effects / Q000627:therapeutic use*; D008111:Liver Function Tests; D008297:Male; D015995:Prevalence; D017678:Sex Distribution; D013321:Strongyloides / Q000187:drug effects* / Q000302:isolation & purification; D013322:Strongyloidiasis / Q000188:drug therapy* / Q000453:epidemiology; D013785:Thailand / Q000453:epidemiology
D000871:Anthelmintics; D007559:Ivermectin; D015766:Albendazole