Antiobesity evaluation of histamine H3 receptor (H3R) antagonist analogs of A-331440 with improved safety and efficacy.
Hancock
A A
AA
Department R4MN, AP9A-3, Abbott Laboratories, Global Pharmaceutical Research and Development, 100 Abbott Park Road, Abbott Park, IL 60064-6125, USA. Art.A.Hancock@Abbott.com
Diehl
M S
MS
Fey
T A
TA
Bush
E N
EN
Faghih
R
R
Miller
T R
TR
Krueger
K M
KM
Pratt
J K
JK
Cowart
M D
MD
Dickinson
R W
RW
Shapiro
R
R
Knourek-Segel
V E
VE
Droz
B A
BA
McDowell
C A
CA
Krishna
G
G
Brune
M E
ME
Esbenshade
T A
TA
Jacobson
P B
PB
D000818:Animals; D001713:Biphenyl Compounds / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology; D017442:Histamine Agonists / Q000737:chemistry / Q000494:pharmacology; D006633:Histamine Antagonists / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D015394:Molecular Structure; D009570:Nitriles / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D009765:Obesity / Q000139:chemically induced / Q000378:metabolism* / Q000517:prevention & control*; D011759:Pyrrolidines / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D018100:Receptors, Histamine H3 / Q000378:metabolism*
C493218:4'-(3-(3(R)-(dimethylamino)-pyrrolidin-1-yl)-propoxy)-biphenyl-4-carbonitrile; D001713:Biphenyl Compounds; D004041:Dietary Fats; D017442:Histamine Agonists; D006633:Histamine Antagonists; D009570:Nitriles; D011759:Pyrrolidines; D018100:Receptors, Histamine H3