title: Paecilosetin, a new bioactive fungal metabolite from a New Zealand isolate of Paecilomyces farinosus.
abstract: A new tetramic acid derivative, paecilosetin (1), along with a recently characterized N-hydroxypyridone, farinosone B (2), was isolated from the fungus Paecilomyces farinosus. Each compound showed activity against the P388 cell line with IC50 values of 3.1 and 1.1 microg/mL, respectively. Paecilosetin was also active against the microorganisms Bacillus subtilis, Trichophyton mentagrophytes, and Cladosporium resinae.
authors.affiliation: Department of Chemistry and School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, New Zealand.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Lang
authors.forename: John W
authors.initials: JW
authors.lastname: Blunt
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Cummings
authors.forename: Anthony L J
authors.initials: AL
authors.lastname: Cole
authors.forename: Murray H G
authors.initials: MH
authors.lastname: Munro
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D002963:Cladosporium / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D020128:Inhibitory Concentration 50; D007941:Leukemia P388; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009520:New Zealand; D010143:Paecilomyces / Q000737:chemistry*; D011728:Pyridones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011760:Pyrrolidinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D011728:Pyridones; D011760:Pyrrolidinones; C495161:farinosone B; C501796:paecilosetin