Identification of bis-quindolines as new antiinfective agents.
Several N-substituted quindolines were made to further evaluate the role of N-alkylation on the activity of indoloquinolines as antifungal agents. While N-5 substitution is required for these activities, N-10 alkylation alone leads to inactive products but is tolerated in the presence of N-5 alkyl groups. It was also discovered that bis-quindolines appear to have a more expanded antimicrobial spectrum and lower cytotoxicity than their monomeric counterparts.
Mardenborough
Leroy G
LG
College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32307, USA.
Zhu
Xue Y
XY
Fan
Pincheng
P
Jacob
Melissa R
MR
Khan
Shabana I
SI
Walker
Larry A
LA
Ablordeppey
Seth Y
SY
D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects; D020128:Inhibitory Concentration 50; D003904:Mitosporic Fungi / Q000187:drug effects; D010963:Plasmodium falciparum / Q000187:drug effects; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000890:Anti-Infective Agents; D011804:Quinolines