title: Catalytic enantioselective fluorination and amination of beta-keto phosphonates catalyzed by chiral palladium complexes.
abstract: [reaction: see text] The catalytic enantioselective fluorination and amination of beta-keto phosphonates catalyzed by chiral palladium complexes is described. Treatment of beta-keto phosphonates with N-fluorobenzenesulfonimide (NFSI) as electrophilic fluorinating reagent and diethyl azodicarboxylate (DEAD) as electrophilic amination reagent under mild reaction conditions afforded the corresponding alpha-substituted beta-keto phosphonates in moderate to excellent yields with excellent enantiomeric excesses.
authors.affiliation: Department of Chemistry, Division of Applied Science, Soonchunhyang University, 644 Eupnae-ri, Shinchang, Asan, Chungnam 336-745, Korea.
authors.forename: Sung Min
authors.initials: SM
authors.lastname: Kim
authors.forename: Hye Ran
authors.initials: HR
authors.lastname: Kim
authors.forename: Dae Young
authors.initials: DY
authors.lastname: Kim