title: Design, synthesis, and evaluation of proline based melanocortin receptor ligands.
abstract: A series of proline based melanocortin ligands has been developed on the basis of initial piperazine leads by using a more conformationally rigid scaffold. A number of these novel ligands showed significant binding affinity for MC3 and MC4 receptors.
authors.affiliation: Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA. tian.x@pg.com
authors.forename: Xinrong
authors.initials: X
authors.lastname: Tian
authors.forename: Timothy
authors.initials: T
authors.lastname: Field
authors.forename: Adam W
authors.initials: AW
authors.lastname: Mazur
authors.forename: Frank H
authors.initials: FH
authors.lastname: Ebetino
authors.forename: John A
authors.initials: JA
authors.lastname: Wos
authors.forename: Doreen
authors.initials: D
authors.lastname: Crossdoersen
authors.forename: Beth B
authors.initials: BB
authors.lastname: Pinney
authors.forename: Russell J
authors.initials: RJ
authors.lastname: Sheldon
mesh_terms: D015195:Drug Design; D006801:Humans; D008024:Ligands; D011392:Proline / Q000737:chemistry* / Q000494:pharmacology; D044101:Receptors, Melanocortin / Q000187:drug effects* / Q000378:metabolism; D013237:Stereoisomerism
chemical_list: D008024:Ligands; D044101:Receptors, Melanocortin; D011392:Proline