title: Decreasing prevalence of beta-lactamase production among respiratory tract isolates of Haemophilus influenzae in the United States.
abstract: A total of 986 isolates of Haemophilus influenzae from patients with respiratory tract infections in 45 United States medical centers were characterized during the winter of 2002-2003. beta-Lactamase production was noted with 26.2% of isolates; 14.6% were resistant to trimethoprim-sulfamethoxazole. Resistance to other relevant antimicrobial agents was extremely uncommon. In comparison to the results of four previous national surveys conducted since 1994, the prevalence of beta-lactamase production with this pathogen appears to be decreasing.
authors.affiliation: Division of Medical Microbiology, Department of Pathology, Roy J. and Lucille A. Carver University of Iowa College of Medicine, Iowa City, IA 52242, USA.
authors.forename: Kris P
authors.initials: KP
authors.lastname: Heilmann
authors.forename: Cassie L
authors.initials: CL
authors.lastname: Rice
authors.forename: Ashley L
authors.initials: AL
authors.lastname: Miller
authors.forename: Norma J
authors.initials: NJ
authors.lastname: Miller
authors.forename: Susan E
authors.initials: SE
authors.lastname: Beekmann
authors.forename: Michael A
authors.initials: MA
authors.lastname: Pfaller
authors.forename: Sandra S
authors.initials: SS
authors.lastname: Richter
authors.forename: Gary V
authors.initials: GV
authors.lastname: Doern
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D005260:Female; D006192:Haemophilus Infections / Q000453:epidemiology / Q000382:microbiology; D006193:Haemophilus influenzae / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D015995:Prevalence; D012137:Respiratory System / Q000382:microbiology; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000382:microbiology; D014481:United States / Q000453:epidemiology; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases