title: Diffusion-weighted magnetic resonance imaging in Marchiafava-Bignami disease: follow-up studies.
abstract: Marchiafava-Bignami disease (MBD), an acute toxic demyelination of the corpus callosum in alcoholics, is associated with poor evolution in the majority of patients. We report here the early and late diffusion magnetic resonance imaging (MRI) and apparent diffusion coefficient (ADC) studies of two patients suffering from MBD with favourable outcome. Diffusion and anatomical MRI changes were parallel to the clinical evolution, suggesting that MRI studies can be helpful for diagnosis and follow-up. Unlike in stroke, restricted diffusion on ADC maps does not seem to be a sign of irreversibility.
authors.affiliation: Department of Radiology, Lyon Sud Hospital, Pierre-Benite, France. chadi.hlaihel@chu-lyon.fr
authors.forename: C
authors.initials: C
authors.lastname: Hlaihel
authors.forename: P-M
authors.initials: PM
authors.lastname: Gonnaud
authors.forename: S
authors.initials: S
authors.lastname: Champin
authors.forename: H
authors.initials: H
authors.lastname: Rousset
authors.forename: V-A
authors.initials: VA
authors.lastname: Tran-Minh
authors.forename: F
authors.initials: F
authors.lastname: Cotton
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000150:complications*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003711:Demyelinating Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D038524:Diffusion Magnetic Resonance Imaging; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013831:Thiamine / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D007328:Insulin; D013831:Thiamine