title: A rot mutation restores parental virulence to an agr-null Staphylococcus aureus strain in a rabbit model of endocarditis.
abstract: Mutations in rot restore in vitro toxin production to agr-negative strains of Staphylococcus aureus. We show that a rot mutation returns wild-type virulence to an agr mutant, as measured in experimental endocarditis infections by target organ bacterial counts. Implications of our data are discussed in terms of agr antagonist strategies.
authors.affiliation: Department of Medical Microbiology & Immunology, 1300 University Avenue, University of Wisconsin, Biochemistry Building, Room 250, Madison, WI 53706, USA. pjmcnamara@facstaff.wisc.edu
authors.forename: Peter J
authors.initials: PJ
authors.lastname: McNamara
authors.forename: Arnold S
authors.initials: AS
authors.lastname: Bayer
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000502:physiology*; D004697:Endocarditis, Bacterial / Q000209:etiology*; D005260:Female; D009154:Mutation; D011817:Rabbits; D012097:Repressor Proteins / Q000502:physiology*; D013203:Staphylococcal Infections / Q000209:etiology*; D013211:Staphylococcus aureus / Q000472:pathogenicity*; D015534:Trans-Activators / Q000502:physiology*; D014774:Virulence
chemical_list: C095698:Agr protein, Staphylococcus aureus; D001426:Bacterial Proteins; D012097:Repressor Proteins; D015534:Trans-Activators; C408643:rot protein, Staphylococcus aureus