Numerical modeling and dosimetry of the 35 mm Petri dish under 46 GHz millimeter wave exposure.
Experimental studies on effects of millimeter wave (MMW) exposure on cells cultured in Petri dishes have attracted interest in recent decades. To improve the quantification of the biological responses toward the MMW energy, an accurate and precise MMW dosimetry is to be provided. By using the finite difference time domain (FDTD) method, the numerical dosimetry is performed for a typical 35 mm Petri dish under 46 GHz continuous MMW exposure from an irradiator of a specified power pattern. With the aim of building a precise model, the meniscus at the interface between the culture solution and the Petri dish sidewall is taken into account, followed by the modeling of smooth edges of the Petri dish. The trilinear interpolation is introduced to assist the FDTD method to obtain a more precise dosimetric assessment. The specific absorption rate (SAR) distributions in the cornea cells covered by culture solution in the Petri dish are calculated and compared to display the effects of using Petri dish models of various precision and the trilinear interpolation on dosimetry results. In addition, the SAR distribution in the cells is analyzed to study its homogeneity. The results indicate that the precise Petri dish model and the application of the trilinear interpolation are helpful in improving the precision of numerical dosimetry. It is also revealed that the inhomogeneity of the SAR distribution is well beyond neglect, which deserves cautious consideration in experiments investigating MMW effects on cells in vitro.
Zhao
Jianxun
J
Department of Biomedical Engineering, School of Electronic Engineering, Xidian University, Xi'an 710071, China. jxzhao@xidian.edu.cn
Wei
Zhenggang
Z
D000042:Absorption; D002478:Cells, Cultured; D003198:Computer Simulation; D003315:Cornea / Q000166:cytology / Q000528:radiation effects; D003470:Culture Media; D046508:Culture Techniques / Q000295:instrumentation*; D004574:Electromagnetic Fields; D006801:Humans; D008954:Models, Biological; D011829:Radiation Dosage; D011874:Radiometry; D013499:Surface Properties; D013997:Time Factors
D003470:Culture Media