title: Frequency dependent effects of subthalamic nucleus stimulation in Parkinson's disease.
abstract: Excessive synchronisation of basal ganglia activity at frequencies < 30 Hz is a hallmark of the parkinsonian state, and may contribute to bradykinesia. Accordingly, we electrically stimulated chronically implanted subthalamic macroelectrodes in 10 Parkinson's disease patients, after overnight withdrawal of anti-parkinsonian medication. We compared the effects of stimulation at 0, 5, 10, 15, 20, 25, 30, and ca. 130 Hz by measuring kinesia time (KT) in a tapping task. Although the effects of direct stimulation were small, frequency-response curves demonstrated local peaks at 5-10 Hz and at 20-25 Hz, superimposed upon an overall tendency for KT to reduce with increasing stimulation frequency. This is consistent with the hypothesis that spontaneous activities in these bands might promote bradykinesia.
authors.affiliation: Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WCIN 3BG, UK.
authors.forename: Noa
authors.initials: N
authors.lastname: Fogelson
authors.forename: Andrea A
authors.initials: AA
authors.lastname: Kühn
authors.forename: Paul
authors.initials: P
authors.lastname: Silberstein
authors.forename: Patricia Dowsey
authors.initials: PD
authors.lastname: Limousin
authors.forename: Marwan
authors.initials: M
authors.lastname: Hariz
authors.forename: Thomas
authors.initials: T
authors.lastname: Trottenberg
authors.forename: Andreas
authors.initials: A
authors.lastname: Kupsch
authors.forename: Peter
authors.initials: P
authors.lastname: Brown
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use; D001611:Beta Rhythm; D046690:Deep Brain Stimulation; D004567:Electrodes, Implanted; D005260:Female; D006801:Humans; D018476:Hypokinesia / Q000503:physiopathology / Q000628:therapy; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D017711:Nonlinear Dynamics; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D011597:Psychomotor Performance / Q000502:physiology; D020531:Subthalamic Nucleus / Q000502:physiology*
chemical_list: D000978:Antiparkinson Agents