title: Effect of basic fibroblast growth factor on fibrovascular ingrowth into porous polyethylene anophthalmic socket implants.
abstract: To investigate the effect of basic Fibroblast Growth Factor (bFGF) on fibrovascular ingrowth into porous polyethylene orbital implants (Medpor) and to investigate any differences according to the method of administration. For the treated groups, after evisceration and Medpor implantation, bFGF was administered by soaking Medpor in the bFGF solution, and/or by injecting bFGF into the Medpor 1 week after the operation. Implants were removed 4 weeks after the operation and examined for the degrees of fibrovascular ingrowth by light microscopy. The percentages of the cross-sectional area of the implant occupied by fibrovascular ingrowth and the numbers of proliferated vessels were significantly higher in the bFGF-treated groups (Mann Whitney test, p<0.05). Administration routes had no effect on the degree of fibrovascular ingrowth (Kruskal-Wallis test, p>0.05). bFGF promoted fibrovascular ingrowth into porous polyethylene orbital implants regardless of the route of administration. Therefore, bFGF might be helpful to prevent complications such as implant exposure.
authors.affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Won Chan
authors.initials: WC
authors.lastname: Park
authors.forename: Soo Kyung
authors.initials: SK
authors.lastname: Han
authors.forename: Nam Ju
authors.initials: NJ
authors.lastname: Kim
authors.forename: Tae Young
authors.initials: TY
authors.lastname: Chung
authors.forename: Sang In
authors.initials: SI
authors.lastname: Khwarg
mesh_terms: D000818:Animals; D017234:Eye Evisceration; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects*; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D020273:Orbital Implants; D020959:Polyethylene; D016062:Porosity; D019919:Prosthesis Implantation; D011817:Rabbits
chemical_list: D016222:Fibroblast Growth Factor 2; D020959:Polyethylene