Sexual development in a 21 month-old boy caused by testosterone contamination of a topical hydrocortisone cream.
Sexual development, including enlargement of the penis, growth acceleration, and growth of pubic hair without an increase in the size of his testes, occurred in a 21 month-old boy over a period of several months. The sexual development was caused by dermal exposure to a hydrocortisone cream, prescribed for eczema, which was contaminated by testosterone. After use of the cream was discontinued, sexual development ceased.
Svoren
Britta M
BM
Division of Endocrinology, Department of Medicine, Children 's Hospital Boston, Harvard Medical School, Boston, MA 02215, USA. britta.svoren@childrens.harvard.edu
Wolfsdorf
Joseph I
JI
D000287:Administration, Topical; D000728:Androgens / Q000009:adverse effects* / Q000097:blood; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D003663:Decision Trees; D004340:Drug Contamination; D004485:Eczema / Q000188:drug therapy*; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage*; D007223:Infant; D008297:Male; D011629:Puberty, Precocious / Q000139:chemically induced* / Q000175:diagnosis; D013739:Testosterone / Q000009:adverse effects* / Q000097:blood
D000728:Androgens; D000893:Anti-Inflammatory Agents; D013739:Testosterone; D006854:Hydrocortisone