Selective H3 receptor (H3R) blockade: broad efficacy in cognition and schizophrenia.
Fox
G B
GB
Neuroscience Research, Abbott Laboratories, AP9A, Global Pharmaceutical Research and Development, Abbott Park, Illinois 60064, USA. gerard.b.fox@abbott.com
Esbenshade
T A
TA
Pan
J B
JB
Browman
K E
KE
Zhang
M
M
Ballard
M E
ME
Radek
R J
RJ
Miner
H
H
Bitner
R S
RS
Krueger
K M
KM
Yao
B B
BB
Faghih
R
R
Rueter
L E
LE
Komater
V A
VA
Drescher
K U
KU
Buckley
M J
MJ
Sullivan
J P
JP
Cowart
M D
MD
Decker
M W
MW
Hancock
A A
AA
D000818:Animals; D001572:Benzofurans / Q000494:pharmacology* / Q000627:therapeutic use; D003071:Cognition / Q000187:drug effects* / Q000502:physiology; D006633:Histamine Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D008568:Memory / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008811:Mice, Inbred DBA; D023421:Models, Animal; D011759:Pyrrolidines / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D018100:Receptors, Histamine H3 / Q000378:metabolism*; D012559:Schizophrenia / Q000188:drug therapy* / Q000378:metabolism*
D001572:Benzofurans; D006633:Histamine Antagonists; D011759:Pyrrolidines; D018100:Receptors, Histamine H3; C496397:benzonitrile, 4-(2-(2-((2r)-2-methyl-1-pyrrolidinyl)ethyl)-5-benzofuranyl)-