title: [The electrophysiological study and implantable cardioverter defibrillator therapy for the patients with Brugada syndrome].
abstract: OBJECTIVE
  Clinical observation of electrophysiological study and implantable cardioverter defibrillator (ICD) therapy in patients with Brugada syndrome.
  
  
  METHODS
  Ten patients (all male) with Brugada wave (spontaneous or propafenone test positive in ECG) underwent electrophysiological study (EPS). The mean age was (41 +/- 10) years. They had no structural heart disease with echocardiogram and the angiogram work-up. The ICD implanted in the patients with EPS-induced ventricular fibrillation in those who were available.
  
  
  RESULTS
  Three patients had the history of familial sudden cardiac death (SCD). Four patients had repeated syncope episodes, two of them had documented ventricular fibrillation during syncope episodes. The AH and HV intervals were 50 - 124 (86 +/- 21) ms and 41 - 84 (58 +/- 15) ms. The ventricular fibrillation was induced in four patients with syncope and atrioventricular reentry tachycardia in one patient with palpitation. Three patients had spontaneous or inducible atrial fibrillation. The ICD implanted in three patients with inducible ventricular fibrillation. Due to economic issue, one patient without ICD implantation had got SCD during follow-up. The patient with atrioventricular reentry tachycardia underwent a successful left atrioventricular accessory pathway ablation.
  
  
  CONCLUSIONS
  The Brugada patients with syncope and high rate of inducible ventricular fibrillation in EPS are the high risk population for SCD, in whom ICD should implant promptly to prevent SCD.
authors.affiliation: Department of Cardiology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Qi-jun
authors.initials: QJ
authors.lastname: Shan
authors.forename: Bing
authors.initials: B
authors.lastname: Yang
authors.forename: Ming-long
authors.initials: ML
authors.lastname: Chen
authors.forename: Jian-gang
authors.initials: JG
authors.lastname: Zou
authors.forename: Dong-jie
authors.initials: DJ
authors.lastname: Xu
authors.forename: Chun
authors.initials: C
authors.lastname: Chen
authors.forename: Ku-lin
authors.initials: KL
authors.lastname: Li
authors.forename: Pin-jun
authors.initials: PJ
authors.lastname: Zhu
authors.forename: Xiao-bing
authors.initials: XB
authors.lastname: Wang
authors.forename: Ke-jiang
authors.initials: KJ
authors.lastname: Cao
mesh_terms: D000328:Adult; D053840:Brugada Syndrome / Q000503:physiopathology* / Q000628:therapy*; D016757:Death, Sudden, Cardiac / Q000517:prevention & control; D017147:Defibrillators, Implantable; D004594:Electrophysiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D014693:Ventricular Fibrillation / Q000628:therapy