title: Identification of bis-quindolines as new antiinfective agents.
abstract: Several N-substituted quindolines were made to further evaluate the role of N-alkylation on the activity of indoloquinolines as antifungal agents. While N-5 substitution is required for these activities, N-10 alkylation alone leads to inactive products but is tolerated in the presence of N-5 alkyl groups. It was also discovered that bis-quindolines appear to have a more expanded antimicrobial spectrum and lower cytotoxicity than their monomeric counterparts.
authors.affiliation: College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32307, USA.
authors.forename: Leroy G
authors.initials: LG
authors.lastname: Mardenborough
authors.forename: Xue Y
authors.initials: XY
authors.lastname: Zhu
authors.forename: Pincheng
authors.initials: P
authors.lastname: Fan
authors.forename: Melissa R
authors.initials: MR
authors.lastname: Jacob
authors.forename: Shabana I
authors.initials: SI
authors.lastname: Khan
authors.forename: Larry A
authors.initials: LA
authors.lastname: Walker
authors.forename: Seth Y
authors.initials: SY
authors.lastname: Ablordeppey
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects; D020128:Inhibitory Concentration 50; D003904:Mitosporic Fungi / Q000187:drug effects; D010963:Plasmodium falciparum / Q000187:drug effects; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D011804:Quinolines