Cyclophosphamide improves the function of post-infarct hearts by reducing old infarct area and accelerating the mobilization of CD34+ cells.
BACKGROUND
Myelosuppressives such as cyclophosphamide (Cy) and 5-fluorouracil (5FU), which can increase circulating CD34+ cells, may have a beneficial effect in the post-infarct heart.


RESULTS
Twenty-four hours after 30-min ischemia-reperfusion, rabbits were intravenously treated with Cy (20 mg/kg), 5FU (15 mg/kg) or saline (S). Cy significantly improved cardiac function and remodeling and decreased the old infarct area 1 month after infarction, compared with those given S. The number of circulating CD34+ cells was higher and neovascularization and matrix metalloproteinase-1 was induced in the Cy group.


CONCLUSIONS
Cy has potential for post-infarct treatment.
Misao
Yu
Y
Department of Cardiology, Regeneration Medicine and Bioethics, Gifu University Graduate School of Medicine, Gifu, Japan.
Arai
Masazumi
M
Ohno
Takamasa
T
Ushikoshi
Hiroaki
H
Takahashi
Tomoyuki
T
Takemura
Genzou
G
Minatoguchi
Shinya
S
Fujiwara
Takako
T
Fujiwara
Hisayoshi
H
D000818:Animals; D018952:Antigens, CD34 / Q000097:blood*; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage*; D003520:Cyclophosphamide / Q000008:administration & dosage*; D015428:Myocardial Reperfusion Injury / Q000097:blood / Q000188:drug therapy*; D011817:Rabbits; D020127:Recovery of Function / Q000187:drug effects*
D018952:Antigens, CD34; D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide