Association between dopamine receptor D3 gene BalI polymorphism and cognitive impulsiveness in alcohol-dependent men.
The gene coding for the dopamine receptor D3 (DRD3) is considered as a major candidate gene in various addictive disorders. Association studies in alcohol-dependence for this gene are nevertheless controversial. We made the hypothesis that phenotypical heterogeneity of alcohol-dependence (i.e. the DRD3 gene is a vulnerability gene in a specific subgroup of patients only) could explain these spurious findings, focusing on a core dimension of addictive disorders, namely impulsiveness. In our sample of 108 French alcohol-dependent patients, patients above the median value for cognitive impulsiveness (one of the three dimensions of the Barratt scale) were more frequently heterozygous than both alcohol-dependent patients with lower impulsiveness (OR = 2.51, P = 0.019) and than 71 healthy controls (OR = 2.32, P = 0.025). Age at interview, antisocial personality disorder, other comorbid addictive disorder, age at onset of alcohol-dependence, and lifetime mood disorders did not constitute confusing intermediate factors.
Limosin
F
F
Service de Psychiatrie Adulte, Faculty of medicine Bichat-Claude Bernard, Louis Mourier hospital (AP-HP), 178, rue des Renouillers, 92701 Colombes cedex, France.
Romo
L
L
Batel
P
P
Adès
J
J
Boni
C
C
Gorwood
Ph
P
D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000437:Alcoholism / Q000453:epidemiology* / Q000235:genetics*; D000987:Antisocial Personality Disorder / Q000175:diagnosis / Q000453:epidemiology; D003071:Cognition; D015897:Comorbidity; D005787:Gene Frequency; D018740:Genetic Heterogeneity; D006801:Humans; D007175:Impulsive Behavior / Q000453:epidemiology* / Q000235:genetics*; D007406:Interview, Psychological; D008297:Male; D019964:Mood Disorders / Q000175:diagnosis / Q000453:epidemiology; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050637:Receptors, Dopamine D3; D011795:Surveys and Questionnaires; D013694:Temperament
C493593:DRD3 protein, human; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3