Improved solution- and solid-phase preparation of hydroxamic acids from esters.
The addition of small amounts of solid KCN to solution and solid-phase esters in THF/MeOH/50% aqueous NH2OH increases the efficiency of their transformation to the corresponding hydroxamic acids.
Ho
Chih Y
CY
Drug Discovery, Johnson & Johnson Pharmaceutical Research and Development, Spring House, Pennsylvania 19446-0776, USA. cho@prius.jnj.com
Strobel
Eric
E
Ralbovsky
Janet
J
Galemmo
Robert A
RA
D002384:Catalysis; D004952:Esters; D006877:Hydroxamic Acids / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D015394:Molecular Structure
D004952:Esters; D006877:Hydroxamic Acids; D007202:Indicators and Reagents