[Salmonella of Indian origin: pseudo-susceptibility to fluoroquinolones].
We report the case of a patient presenting with typhoid fever after returning from a stay in India. This infection was not cured with a course of ciprofloxacin, due to a reduced susceptibility of the bacteria to the drug. This decreased susceptibility to fluoroquinolones was not detected by the antibiogram, but the MIC for nalidixic acid was greater than 32 mg/l. This case suggests using a third generation cephalosporin instead of a quinolone, for people coming from a high-risk zone. It also suggests that the MIC for nalidixic acid and for norfloxacin can be used as the first clue for a reduced susceptibility to fluoroquinolones.
Denes
E
E
Service des maladies infectieuses et tropicales, CHU Dupuytren, 2, avenue Martin-Luther-King, 87042 Limoges cedex, France. eric.denes@unilim.fr
Gondran
G
G
Bezanahary
H
H
Genet
C
C
Rogez
J P
JP
Weinbreck
P
P
Martin
C
C
D000328:Adult; D024841:Fluoroquinolones / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007194:India; D008297:Male; D008826:Microbial Sensitivity Tests; D012480:Salmonella Infections / Q000175:diagnosis / Q000188:drug therapy*; D012485:Salmonella typhi / Q000187:drug effects*; D014195:Travel; D014435:Typhoid Fever / Q000175:diagnosis / Q000188:drug therapy*
D024841:Fluoroquinolones