title: Synthesis and characterization of polyanhydride for local BCNU delivery carriers.
abstract: p-Carboxyphenoxy propane (CPP) prepolymer consisting of 4 units and sebacic acid (SA) prepolymer consisting of about 10 units were synthesized by reacting CPP and SA in the presence of excess acetic anhydride, respectively. Polyanhydride, poly(CPP-SA) copolymers were copolymerized by a melt polycondensation process with a mixture of CPP and SA prepolymer. Copolymers of average molecular weight up to 110,000 g/mol were achieved. The crystallinity of poly(CPP-SA) copolymers was decreased by the addition of the CPP homopolymer segment to SA homopolymer. Poly(CPP-SA) copolymers gradually degraded for period of 10 days. No large difference of weight loss observed according to molecular weight variation of poly(CPP-SA) copolymers. BCNU release from wafers fabricated by poly(CPP-SA) showed a sustained release pattern with no initial burst and delay of drug release.
authors.affiliation: Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology, PO Box 107, Yuseong, Daejeon 305-600, Korea.
authors.forename: Moon Suk
authors.initials: MS
authors.lastname: Kim
authors.forename: Kwang Su
authors.initials: KS
authors.lastname: Seo
authors.forename: Ha Soo
authors.initials: HS
authors.lastname: Seong
authors.forename: Sun Hang
authors.initials: SH
authors.lastname: Cho
authors.forename: Hai Bang
authors.initials: HB
authors.lastname: Lee
authors.forename: Keum Duck
authors.initials: KD
authors.lastname: Hong
authors.forename: Sun Kyung
authors.initials: SK
authors.lastname: Kim
authors.forename: Gilson
authors.initials: G
authors.lastname: Khang
mesh_terms: D000812:Anhydrides; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage*; D001672:Biocompatible Materials / Q000737:chemistry*; D002330:Carmustine / Q000008:administration & dosage*; D003652:Decanoic Acids / Q000737:chemistry*; D003998:Dicarboxylic Acids / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D006358:Hot Temperature; D062425:Hydroxybenzoate Ethers; D062385:Hydroxybenzoates / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D049388:Polyanhydrides / Q000737:chemistry* / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry*; D013229:Stearic Acids / Q000737:chemistry*; D013696:Temperature; D013816:Thermodynamics; D013997:Time Factors
chemical_list: D000812:Anhydrides; D018906:Antineoplastic Agents, Alkylating; D001672:Biocompatible Materials; D003652:Decanoic Acids; D003998:Dicarboxylic Acids; D004337:Drug Carriers; D062425:Hydroxybenzoate Ethers; D062385:Hydroxybenzoates; D049388:Polyanhydrides; D011108:Polymers; D013229:Stearic Acids; C090873:stearic-sebacic acid polyanhydride copolymer; C078320:1,3-bis(4-carboxyphenoxy)propane; C011107:sebacic acid; D002330:Carmustine