Sequence analysis of near full-length HIV type 1 subtype D primary strains isolated in Cape Town, South Africa, from 1984 to 1986.
South Africa has one of the fastest growing HIV-1 epidemics worldwide, consisting mostly of subtype C. However, HIV-1 subtype B and subtype D viruses were isolated in the beginning of the epidemic in the early 1980s. This study describes the amplification, cloning, and near full-length genome sequencing of four HIV-1 subtype D primary strains, isolated from 1984 to 1986 in Cape Town, in what seems to have been a small restricted subtype D epidemic in the country.
Loxton
André G
AG
Department of Medical Virology, National Health Laboratory Service (NHLS) and University of Stellenbosch, Tygerberg Academic Hospital, Tygerberg, 7505, South Africa.
Treurnicht
Florette
F
Laten
Annette
A
van Rensburg
Estrelita Janse
EJ
Engelbrecht
Susan
S
D004196:Disease Outbreaks; D016679:Genome, Viral; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology; D015497:HIV-1 / Q000145:classification* / Q000235:genetics; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D013019:South Africa / Q000453:epidemiology