The total synthesis of spectinabilin and its biomimetic conversion to SNF4435C and SNF4435D.
[reaction: see text] A short synthesis of (+/-)-spectinabilin via a trans-selective Suzuki coupling and subsequent Negishi-type methylation, and its biomimetic conversion to (+/-)-SNF4435C and (+/-)-SNF4435D is described.
Jacobsen
Mikkel F
MF
Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, United Kingdom.
Moses
John E
JE
Adlington
Robert M
RM
Baldwin
Jack E
JE
D018716:Molecular Mimicry; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*; D011753:Pyrones / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
D009574:Nitro Compounds; D011753:Pyrones; C435067:SNF 4435C; C435066:SNF 4435D; C508401:spectinabilin