Ethyl alpha-D-glucoside increases urine volume and causes renal morphologic changes in rats.
Ethyl alpha-D-glucoside (alpha-EG) is a peculiar component in sake, a traditional Japanese alcoholic beverage. In this study, morphological changes in kidney and effects on urine excretion by alpha-EG ingestion were investigated. After the rats were fed with pellet diets containing 100% or 20% alpha-EG dietary level, alpha-EG was detected in urine and urine volume showed significant increase (p<0.05). Kidney weights were increased (p<0.05) and renal tubules were dilated in the rats by alpha-EG ingestion, whereas there was no detectable histopathological damage to renal cells. Plasma uric acid and urea levels were not affected. In conclusion, ingested alpha-EG was excreted in urine, increasing urine volume. Increase in kidney weight related to renal tubule dilation was observed with alpha-EG ingestion without deteriorate changes in the renal cells or functions.
Mishima
Tomoyuki
T
The United Graduate School of Agricultural Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan. h6103007@guedu.cc.gifu-u.ac.jp
Katayama
Yumiko
Y
Takagi
Yoshie
Y
Ozeki
Kenji
K
Hayakawa
Takashi
T
Tsuge
Haruhito
H
D000434:Alcoholic Beverages / Q000032:analysis; D000818:Animals; D004108:Dilatation, Pathologic / Q000139:chemically induced; D005960:Glucosides / Q000009:adverse effects* / Q000494:pharmacology / Q000652:urine; D007668:Kidney / Q000033:anatomy & histology* / Q000187:drug effects*; D007684:Kidney Tubules / Q000187:drug effects / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D014556:Urine
D005960:Glucosides; C108400:ethyl glucoside