Ultrastructural studies of human basophils and mast cells.
Ultrastructural studies of human mast cells (HMCs) and basophils (HBs) are reviewed. Sources of HMCs include biopsies of tissue sites and in situ study of excised diseased organs; isolated, partially purified samples from excised organs; and growth-factor-stimulated mast cells that develop de novo in cultures of cord blood cells. Sources of HBs for study include partially purified peripheral blood basophils, basophils in tissue biopsies, and specific growth factor-stimulated basophils arising de novo from cord blood cells. The ultrastructural studies reviewed deal with identity, secretion, vesicles, recovery, and synthesis issues related to the biology of these similar cells.
Dvorak
Ann M
AM
Department of Pathology/East Campus, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA. advorak@bidmc.harvard.edu
D000818:Animals; D001491:Basophils / Q000378:metabolism / Q000648:ultrastructure*; D006801:Humans; D008407:Mast Cells / Q000378:metabolism / Q000648:ultrastructure*