title: Capsaicin failed in suppressing cortical processing of CO2 laser pain in migraine patients.
abstract: The aim of this study was to compare the properties of the nociceptive system in eight migraine without aura patients in the pain-free phase with 10 healthy controls, by evaluating the topography and the source of the CO2 laser-evoked potentials (LEPs) obtained by the right supraorbital skin, during and after capsaicin topical application. In healthy subjects the acute cutaneous pain induced by capsaicin reduced the amplitude of the vertex LEPs and induced a posterior shifting of the P2 wave dipolar source within the anterior cingulate cortex. These functional changes seemed significantly reduced in migraine patients, for a disturbed pattern of pain modulation at the cortical level, which may subtend the onset and persistence of migraine.
authors.affiliation: Neuroscience Department, University of Bari, Bari, Italy. m.detommaso@neurol.uniba.it
authors.forename: Marina
authors.initials: M
authors.lastname: de Tommaso
authors.forename: Luciana
authors.initials: L
authors.lastname: Losito
authors.forename: Olimpia
authors.initials: O
authors.lastname: Difruscolo
authors.forename: Michele
authors.initials: M
authors.lastname: Sardaro
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Libro
authors.forename: Marco
authors.initials: M
authors.lastname: Guido
authors.forename: Paolo
authors.initials: P
authors.lastname: Lamberti
authors.forename: Paolo
authors.initials: P
authors.lastname: Livrea
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping; D002211:Capsaicin / Q000494:pharmacology*; D016022:Case-Control Studies; D004569:Electroencephalography / Q000379:methods; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008881:Migraine Disorders / Q000473:pathology / Q000503:physiopathology*; D010147:Pain Measurement / Q000379:methods; D017288:Pain Threshold / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012867:Skin / Q000294:innervation / Q000503:physiopathology
chemical_list: D002211:Capsaicin