Evaluation of clinical and serological data from Taenia solium cysticercosis patients in eastern Inner Mongolia Autonomous Region, China.
Neurocysticercosis (NCC) is one of the major causes of neurological disease in China. ELISA and immunoblotting using glycoproteins purified by preparative isoelectric focusing were used to detect human cysticercosis in Tongliao area, Inner Mongolia, China in 1998. Approximately 89% (39 of 44 inpatients and outpatients with suspected NCC at Tongliao City Hospital) were residents of Inner Mongolia. About 53% were male and 77% were of working age (18-59 years), and 32% were farmers. Immunoblotting and ELISA showed a high correlation. Of the 44 patients, 31 positive by cerebral computed tomography (CT) scan were confirmed serologically to have cysticercosis. In the ELISA, patients with no lesions by CT scan had lower OD values, similar to those of normal serum. These findings confirm that both ELISA and immunoblotting assays are sufficiently sensitive to detect asymptomatic or symptomatic cysticercosis patients.
Ikejima
T
T
China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang 110016, China. ikejimat@vip.sina.com
Piao
Z-X
ZX
Sako
Y
Y
Sato
M O
MO
Bao
S
S
Si
R
R
Yu
F
F
Zhang
C-L
CL
Nakao
M
M
Yamasaki
H
H
Nakaya
K
K
Kanazawa
T
T
Ito
A
A
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D002681:China / Q000453:epidemiology; D003551:Cysticercosis / Q000175:diagnosis* / Q000453:epidemiology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015151:Immunoblotting; D008297:Male; D008875:Middle Aged; D020019:Neurocysticercosis / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D041201:Taenia solium / Q000276:immunology*
D000909:Antibodies, Helminth