title: A randomized, double-blind, placebo-controlled study on the clinical efficacy of oral treatment with DermaVite on ageing symptoms of the skin.
abstract: In this double-blind, placebo-controlled study, 40 women with ageing symptoms of the skin were randomized to receive DermaVite, a new preparation containing marine proteins, alpha-lipoic acid, pine bark extract, vitamins and minerals (n = 20), or placebo (n = 20) twice daily for 6 months. Objective measurements of skin thickness and elasticity, together with subjective clinical assessments of various parameters (fine wrinkles, coarse wrinkles, tactile roughness and teleangiectasia) were used to evaluate changes after 2, 4 and 6 months' treatment. Self-evaluations were also made by the study participants. There was a significant improvement in skin quality in both objective and subjective parameters after treatment with Dermavite compared with placebo. Participants' self-evaluations also showed a statistically significant difference in favour of the active treatment. The treatment was very well tolerated. Based on this efficacy and tolerability study, DermaVite can be considered a suitable therapy for ageing symptoms of the skin.
authors.affiliation: ETC Research, Oslo, Norway. erlingthom@etc.as
authors.forename: E
authors.initials: E
authors.lastname: Thom
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000375:Aging; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008875:Middle Aged; D028223:Pinus; D010919:Placebos; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage* / Q000494:pharmacology; D011506:Proteins / Q000008:administration & dosage* / Q000494:pharmacology; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D015595:Skin Aging / Q000187:drug effects*; D008063:Thioctic Acid / Q000008:administration & dosage* / Q000494:pharmacology; D013997:Time Factors
chemical_list: D010919:Placebos; D010936:Plant Extracts; D011506:Proteins; D008063:Thioctic Acid