title: Childhood growth and future development of psychotic disorder among Helsinki high-risk children.
abstract: BACKGROUND
  The Helsinki High-Risk (HR) Study is a follow-up study of offspring (born between 1960 and 1964) of all females treated for schizophrenia spectrum disorders in mental hospitals in Helsinki before 1975, and controls.
  
  
  OBJECTIVE
  To compare childhood growth among HR and control children, and to determine if any patterns in childhood growth predict later development of psychotic disorders within the HR group.
  
  
  METHODS
  We accessed growth information from childhood health cards, which we obtained for 114 HR and 53 control offspring. The growth of HR children was compared with that of control children. Within the HR group, we investigated whether any association existed between childhood growth patterns and morbidity from psychotic disorders using logistic regression models.
  
  
  RESULTS
  The HR girls were shorter than controls at birth (p=0.030), but this disparity vanished by age 7. In contrast, HR boys were only slightly shorter at birth than controls, but the height difference increased with age, being statistically significant at 10 years (p=0.020). Among HR children, the combination of being in the lowest tertile for ponderal index at birth but in the highest tertile for BMI at 7 years predicted later development of schizophrenia (OR 22.8, 95% CI 2.0, >100, p=0.040).
  
  
  CONCLUSIONS
  Catch-up growth increases the risk of schizophrenia among offspring of mothers with psychotic disorder. Whether this is an independent risk factor or merely a reflection of some other risk factors needs further research.
authors.affiliation: Department of Mental Health and Alcohol Research, KTL, National Public Health Institute, Mannerheimintie, Helsinki, Finland. laura.niemi@ktl.fi
authors.forename: Laura T
authors.initials: LT
authors.lastname: Niemi
authors.forename: Jaana M
authors.initials: JM
authors.lastname: Suvisaari
authors.forename: Jari K
authors.initials: JK
authors.lastname: Haukka
authors.forename: Jouko K
authors.initials: JK
authors.lastname: Lönnqvist
mesh_terms: D000293:Adolescent; D000328:Adult; D001724:Birth Weight; D001827:Body Height / Q000235:genetics*; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D005260:Female; D005387:Finland; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D012016:Reference Values; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*; D012569:Schizotypal Personality Disorder / Q000175:diagnosis / Q000235:genetics*; D012737:Sex Factors; D013223:Statistics as Topic