Synthesis and characterization of polyanhydride for local BCNU delivery carriers.
p-Carboxyphenoxy propane (CPP) prepolymer consisting of 4 units and sebacic acid (SA) prepolymer consisting of about 10 units were synthesized by reacting CPP and SA in the presence of excess acetic anhydride, respectively. Polyanhydride, poly(CPP-SA) copolymers were copolymerized by a melt polycondensation process with a mixture of CPP and SA prepolymer. Copolymers of average molecular weight up to 110,000 g/mol were achieved. The crystallinity of poly(CPP-SA) copolymers was decreased by the addition of the CPP homopolymer segment to SA homopolymer. Poly(CPP-SA) copolymers gradually degraded for period of 10 days. No large difference of weight loss observed according to molecular weight variation of poly(CPP-SA) copolymers. BCNU release from wafers fabricated by poly(CPP-SA) showed a sustained release pattern with no initial burst and delay of drug release.
Kim
Moon Suk
MS
Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology, PO Box 107, Yuseong, Daejeon 305-600, Korea.
Seo
Kwang Su
KS
Seong
Ha Soo
HS
Cho
Sun Hang
SH
Lee
Hai Bang
HB
Hong
Keum Duck
KD
Kim
Sun Kyung
SK
Khang
Gilson
G
D000812:Anhydrides; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage*; D001672:Biocompatible Materials / Q000737:chemistry*; D002330:Carmustine / Q000008:administration & dosage*; D003652:Decanoic Acids / Q000737:chemistry*; D003998:Dicarboxylic Acids / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D006358:Hot Temperature; D062425:Hydroxybenzoate Ethers; D062385:Hydroxybenzoates / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D049388:Polyanhydrides / Q000737:chemistry* / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry*; D013229:Stearic Acids / Q000737:chemistry*; D013696:Temperature; D013816:Thermodynamics; D013997:Time Factors
D000812:Anhydrides; D018906:Antineoplastic Agents, Alkylating; D001672:Biocompatible Materials; D003652:Decanoic Acids; D003998:Dicarboxylic Acids; D004337:Drug Carriers; D062425:Hydroxybenzoate Ethers; D062385:Hydroxybenzoates; D049388:Polyanhydrides; D011108:Polymers; D013229:Stearic Acids; C090873:stearic-sebacic acid polyanhydride copolymer; C078320:1,3-bis(4-carboxyphenoxy)propane; C011107:sebacic acid; D002330:Carmustine