title: IMRT versus conventional 3DCRT on prostate and normal tissue dosimetry using an endorectal balloon for prostate immobilization.
abstract: This study was undertaken to compare prostate and normal tissue dosimetry in prostate cancer patients treated with intensity-modulated radiation therapy (IMRT) and conventional 3-dimensional conformal radiotherapy (3DCRT) using an endorectal balloon for prostate immobilization. Ten prostate cancer patients were studied using both IMRT and conventional 3DCRT at Houston Veterans Affairs Medical Center. For IMRT, the prescription was 70 Gy at 2 Gy/fraction at the 83.4% isodose line, allowing no more than 15% of the rectum and 33% of the bladder to receive above 68 and 65 Gy, respectively. For conventional 3DCRT, a 6-field arrangement with lateral and oblique fields was used to deliver 76 Gy at 2Gy/fraction, ensuring complete tumor coverage by the 72-Gy isodose line. Mean doses for prostate and seminal vesicles were 75.10 and 75.11 Gy, respectively, for IMRT and 75.40 and 75.02 Gy, respectively, for 3DCRT (p > 0.218). 3DCRT delivered significantly higher doses to 33%, 50%, and 66% volumes of rectum by 3.55, 6.64, and 10.18 Gy, respectively (p < 0.002), and upper rectum by 7.26, 9.86, and 9.16 Gy, respectively (p < 0.007). 3DCRT also delivered higher doses to femur volumes of 33% and 50% by 9.38 and 10.19 Gy, respectively, (p < 0.001). Insignificant differences in tumor control probability (TCP) values between IMRT and 3DCRT were calculated for prostate (p = 0.320) and seminal vesicles (p = 0.289). Compared to 3DCRT, IMRT resulted in significantly reduced normal tissue complication probability (NTCP) only for upper rectum (p = 0.025) and femurs (p = 0.021). This study demonstrates that IMRT achieves superior normal tissue avoidance, especially for rectum and femurs compared to 3DCRT, with comparable target dose escalation.
authors.affiliation: Department of Veterans Affairs Medical Center, Houston, TX, USA. vlachaki@med.nyu.edu
authors.forename: Maria T
authors.initials: MT
authors.lastname: Vlachaki
authors.forename: Terrance N
authors.initials: TN
authors.lastname: Teslow
authors.forename: Chad
authors.initials: C
authors.lastname: Amosson
authors.forename: Nathan W
authors.initials: NW
authors.lastname: Uy
authors.forename: Salahuddin
authors.initials: S
authors.lastname: Ahmad
mesh_terms: D000328:Adult; D002404:Catheterization; D005269:Femur; D006801:Humans; D007103:Immobilization / Q000295:instrumentation*; D008297:Male; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D020266:Radiotherapy, Conformal; D012007:Rectum; D012669:Seminal Vesicles; D001743:Urinary Bladder