Electroanalysis of tetracycline using nickel-implanted boron-doped diamond thin film electrode applied to flow injection system.
The electrochemical analysis of tetracycline was investigated using nickel-implanted boron-doped diamond thin film electrode by cyclic voltammetry and amperometry with a flow injection system. Cyclic voltammetry was used to study the electrochemical oxidation of tetracycline. Comparison experiments were carried out using as-deposited boron-doped diamond thin film electrode (BDD). Nickel-implanted boron-doped diamond thin film electrode (Ni-DIA) provided well-resolved oxidation irreversible cyclic voltammograms. The current signals were higher than those obtained using the as-deposited BDD electrode. Results using nickel-implanted boron-doped diamond thin film electrode in flow injection system coupled with amperometric detection are presented. The optimum potential for tetracycline was 1.55 V versus Ag/AgCl. The linear range of 1.0 to 100 microM and the detection limit of 10 nM were obtained. In addition, the application for drug formulation was also investigated.
Treetepvijit
Surudee
S
Department of Chemistry, Faculty of Science, Chulalongkorn University, Patumwan, Bangkok 10330, Thailand.
Chuanuwatanakul
Suchada
S
Einaga
Yasuaki
Y
Sato
Rika
R
Chailapakult
Orawon
O
D000900:Anti-Bacterial Agents / Q000032:analysis*; D001895:Boron / Q000737:chemistry*; D002214:Capsules / Q000032:analysis; D004563:Electrochemistry; D004566:Electrodes; D017022:Flow Injection Analysis; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D009532:Nickel / Q000737:chemistry*; D013752:Tetracycline / Q000032:analysis*
D000900:Anti-Bacterial Agents; D002214:Capsules; D007202:Indicators and Reagents; D009532:Nickel; D013752:Tetracycline; D001895:Boron