Biosynthesized tea polyphenols inactivate Chlamydia trachomatis in vitro.
Biosynthesized tea polyphenols showed antichlamydial activity against Chlamydia trachomatis D/UW-3/Cx and L2/434/Bu using cell culture. The most active compounds were (-)-epigallocatechin gallate and (-)-epicatechin gallate, followed by (-)-epicatechin (EC). (+)-Epicatechin and (-)-epigallocatechin were intermediate. EC was the least toxic. These results warrant evaluation of tea polyphenols as topical antichlamydial agents.
Yamazaki
Tsutomu
T
Department of Virology 1, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku, Tokyo, Japan 162-8640. tochaben@gray.plala.or.jp
Kishimoto
Toshio
T
Shiga
Sadashi
S
Sato
Kozue
K
Hagiwara
Toshikatsu
T
Inoue
Miyuki
M
Sasaki
Nozomu
N
Ouchi
Kazunobu
K
Hara
Yukihiko
Y
D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology*; D002392:Catechin / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology; D002692:Chlamydia trachomatis / Q000187:drug effects* / Q000254:growth & development; D005419:Flavonoids / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology*; D006367:HeLa Cells / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D059808:Polyphenols; D013662:Tea / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D013662:Tea; D002392:Catechin; C062669:epicatechin gallate; C045651:epigallocatechin gallate