title: Disinfection of immature teeth with a triple antibiotic paste.
abstract: This study assessed the efficacy of a triple antibiotic paste in the disinfection of immature dog teeth with apical periodontitis. The canals were sampled before (S1) and after (S2) irrigation with 1.25% NaOCL and after dressing with a triple antibiotic paste (S3), consisting of metronidazole, ciprofloxacin, and minocycline. At S1, 100% of the samples cultured positive for bacteria with a mean CFU count of 1.7 x 10. At S2, 10% of the samples cultured bacteria-free with a mean CFU count of 1.4 x 10. At S3, 70% of the samples cultured bacteria-free with a mean CFU count of only 26. Reductions in mean CFU counts between S1 and S2 (p < 0.0001) as well as between S2 and S3 (p < 0.0001) were statistically significant. These results indicate the effectiveness of a triple antibiotic paste in the disinfection of immature teeth with apical periodontitis.
authors.affiliation: Department of Endodontics, The University of North Carolina, Chapel Hill, NC 27599, USA.
authors.forename: William
authors.initials: W
authors.lastname: Windley
authors.forename: Fabricio
authors.initials: F
authors.lastname: Teixeira
authors.forename: Linda
authors.initials: L
authors.lastname: Levin
authors.forename: Asgeir
authors.initials: A
authors.lastname: Sigurdsson
authors.forename: Martin
authors.initials: M
authors.lastname: Trope
mesh_terms: D000818:Animals; D001421:Bacteria, Anaerobic / Q000187:drug effects; D002939:Ciprofloxacin / Q000494:pharmacology / Q000627:therapeutic use; D015169:Colony Count, Microbial; D003782:Dental Pulp / Q000098:blood supply; D004285:Dogs; D004359:Drug Therapy, Combination / Q000494:pharmacology / Q000627:therapeutic use*; D008795:Metronidazole / Q000494:pharmacology / Q000627:therapeutic use; D008911:Minocycline / Q000494:pharmacology / Q000627:therapeutic use; D018919:Neovascularization, Physiologic; D010485:Periapical Periodontitis / Q000188:drug therapy*; D012388:Root Canal Irrigants / Q000494:pharmacology / Q000627:therapeutic use*; D012973:Sodium Hypochlorite / Q000494:pharmacology / Q000627:therapeutic use; D019227:Tooth Apex / Q000254:growth & development
chemical_list: D012388:Root Canal Irrigants; D008795:Metronidazole; D002939:Ciprofloxacin; D012973:Sodium Hypochlorite; D008911:Minocycline