title: Suppression of laser-induced choroidal neovascularization by posterior sub-tenon administration of triamcinolone acetonide.
abstract: OBJECTIVE
  To evaluate the inhibitory effect of triamcinolone acetonide (TA) on choroidal neovascularization (CNV) by posterior sub-Tenon administration using a laser-induced CNV model in the rat.
  
  
  METHODS
  Experimental CNV was induced by laser photocoagulation in Brown-Norway male rats. Experimental eyes received posterior sub-Tenon administration of either 2 mg (n = 10) or 0.5 mg (n = 8) of TA. Control eyes (n = 10) received posterior sub-Tenon administration of isotonic sodium chloride solution. Two weeks after treatment, CNV was evaluated by fluorescein angiography and histopathological examination. Concentrations of TA in the vitreous, retina, and choroid were determined by high-performance liquid chromatography at 3 and 7 days after posterior sub-Tenon administration.
  
  
  RESULTS
  The eyes treated with 2 mg of TA showed statistically significant inhibition of fluorescein leakage by fluorescein angiography, as compared with control eyes and eyes treated with 0.5 mg of TA (P < 0.01). The thickness of CNV membranes in eyes treated with 2 mg of TA also decreased statistically significantly, as compared with control eyes (P < 0.01). TA was detected in the vitreous, retina, and choroid 3 days after administration and in the choroid 7 days after administration.
  
  
  CONCLUSIONS
  Posterior sub-Tenon administration of TA may be useful to treat CNV.
authors.affiliation: Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Aki
authors.initials: A
authors.lastname: Kato
authors.forename: Hideya
authors.initials: H
authors.lastname: Kimura
authors.forename: Komei
authors.initials: K
authors.lastname: Okabe
authors.forename: Junko
authors.initials: J
authors.lastname: Okabe
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Kunou
authors.forename: Miho
authors.initials: M
authors.lastname: Nozaki
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Ogura
mesh_terms: D000818:Animals; D002199:Capillary Permeability; D020256:Choroidal Neovascularization / Q000188:drug therapy* / Q000209:etiology; D002851:Chromatography, High Pressure Liquid; D003238:Connective Tissue / Q000187:drug effects*; D004195:Disease Models, Animal; D005451:Fluorescein Angiography; D005938:Glucocorticoids / Q000008:administration & dosage*; D017075:Laser Coagulation / Q000009:adverse effects; D008297:Male; D051381:Rats; D011914:Rats, Inbred BN; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*
chemical_list: D005938:Glucocorticoids; D014222:Triamcinolone Acetonide