Flurothyl seizures susceptibility is increased in prenatally methamphetamine-exposed adult male and female rats.
The purpose of the present study was to examine the effect of prenatal methamphetamine (MA) exposure on flurothyl seizures. Adult prenatally MA-exposed male rats had decreased threshold of the first fasciculation and clonic seizure. In adult female rats, prenatal MA exposure decreased the threshold of the first fascicualtion in diestrous females, while there were no changes in proestrous or estrous females. The tonic-clonic seizure threshold was not altered by prenatal MA exposure.
Slamberová
R
R
Departments of Normal, Pathological and Clinical Physiology, 3rd Faculty of Medicine, Charles University, Ke Karlovu 4, 120 00 Praha 2, Prague, Czech Republic. rslamber@lf3.cuni.cz
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D030762:Estrous Cycle / Q000187:drug effects; D005260:Female; D005481:Flurothyl; D008297:Male; D008694:Methamphetamine / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology; D012737:Sex Factors
D008694:Methamphetamine; D005481:Flurothyl