Biotransformation of chrysin and apigenin by Cunninghamella elegans.
Biotransformation of chrysin by Cunninghamella elegans NRRL 1392 produced apigenin, apigenin 7-sulfate, apigenin 7,4'-disulfate, and a new metabolite identified as chrysin 7-sulfate. On the other hand, fermentation of apigenin, using the same microorganism, yielded apigenin 7-sulfate and apigenin 7,4'-disulfate. The structures of the metabolites were established by spectral analysis, and acid and enzyme hydrolyses in addition to comparison with reference samples.
Ibrahim
Abdel-Rahim Sayed
AR
Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta 8130, Egypt. arsib16@hotmail.com
D047310:Apigenin / Q000737:chemistry / Q000378:metabolism*; D001711:Biotransformation; D020093:Cunninghamella / Q000378:metabolism*; D005419:Flavonoids / Q000737:chemistry / Q000378:metabolism*
D005419:Flavonoids; C043561:chrysin; D047310:Apigenin