title: Antitrypanosomal activity of a novel norlignan purified from Nectandra lineata.
abstract: Bioactivity-guided fractionation of a MeOH-EtOAc extract from the young leaves of Nectandra lineata (Lauraceae), using a Trypanosoma cruzi bioassay resulted in the isolation of a novel norlignan 3'-methoxy-3,4-methylenedioxy-4',7-epoxy-9-nor-8,5'-neolignan-9'-acetoxy (1), together with the known compound, 3'-methoxy-3,4-methylenedioxy-4'-7-epoxy-9-nor-8,5'-neolignan-7,8'-diene (2). Compounds 1 and 2 were shown to inhibit the growth of T. cruzi epimastigotes in axenic culture.
authors.affiliation: Laboratory of Natural Products, Faculty of Natural and Exact Sciences and Technology Apdo. 0824, University of Panama, Panama City, Republic of Panama.
authors.forename: Lilia
authors.initials: L
authors.lastname: Chérigo
authors.forename: Venancio
authors.initials: V
authors.lastname: Polanco
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ortega-Barria
authors.forename: Maria V
authors.initials: MV
authors.lastname: Heller
authors.forename: Todd L
authors.initials: TL
authors.lastname: Capson
authors.forename: Luis Cubilla
authors.initials: LC
authors.lastname: Rios
mesh_terms: D000475:Alkenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D019770:Lauraceae / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D014344:Trypanocidal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects
chemical_list: C503450:3'-methoxy-3,4-methylenedioxy-4',7-epoxy-9-nor-8,5'-neolignan-9'-acetoxy; C503449:3'-methoxy-3,4-methylenedioxy-4'-7-epoxy-9-nor-8,5'-neolignan-7,8'-diene; D000475:Alkenes; D017705:Lignans; D014344:Trypanocidal Agents