Design, synthesis, and evaluation of proline based melanocortin receptor ligands.
A series of proline based melanocortin ligands has been developed on the basis of initial piperazine leads by using a more conformationally rigid scaffold. A number of these novel ligands showed significant binding affinity for MC3 and MC4 receptors.
Tian
Xinrong
X
Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA. tian.x@pg.com
Field
Timothy
T
Mazur
Adam W
AW
Ebetino
Frank H
FH
Wos
John A
JA
Crossdoersen
Doreen
D
Pinney
Beth B
BB
Sheldon
Russell J
RJ
D015195:Drug Design; D006801:Humans; D008024:Ligands; D011392:Proline / Q000737:chemistry* / Q000494:pharmacology; D044101:Receptors, Melanocortin / Q000187:drug effects* / Q000378:metabolism; D013237:Stereoisomerism
D008024:Ligands; D044101:Receptors, Melanocortin; D011392:Proline