title: [Primary generalized dystonia and deep brain stimulation: a randomized, placebo-controlled, double-blind, multicentre study].
abstract: Dystonia describes a group of movement disorders characterized by involuntary muscle contractions which cause twisting involuntary movements and/or abnormal postures. Primary generalized dystonia often begins in childhood and over a number of years leads to a serious and debilitating illness. The effects of medication and physiotherapy are often disappointing. In the Netherlands a randomized, placebo-controlled and double-blind study has been started to examine the effects and risks of long-term deep brain stimulation in patients with primary generalized dystonia.
authors.affiliation: Academisch Medisch Centrum/Universiteit van Amsterdam, afd. Neurologie, Postbus 22.660, 1100 DD Amsterdam. e.m.foncke@amc.uva.nl
authors.forename: E M J
authors.initials: EM
authors.lastname: Foncke
authors.forename: J D
authors.initials: JD
authors.lastname: Speelman
mesh_terms: D046690:Deep Brain Stimulation / Q000009:adverse effects; D004311:Double-Blind Method; D004421:Dystonia / Q000628:therapy*; D006801:Humans; D015337:Multicenter Studies as Topic; D009426:Netherlands; D016032:Randomized Controlled Trials as Topic