Nucleophilic trifluoromethylation of imines using the CF3I/TDAE reagent.
The nucleophilic trifluoromethylation reagent derived from CF3I and tetrakis(dimethylamino)ethylene (TDAE) was found to be effective in addition to both N-tosyl aldimines and N-tolyl sulfinimines, the latter reaction exhibiting very good diastereoselectivity.
Xu
Wei
W
Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, USA.
Dolbier
William R
WR