Clinico-laboratory findings in male lupus patients from a tertiary care hospital, Pakistan.
This study was conducted to delineate the clinical pattern of a cohort of Pakistani male patients with systemic lupus erythematosus (SLE). Clinical and laboratory data were collected of 24 male patients who were diagnosed with SLE and admitted to a tertiary care hospital between 1986 and 2001. Imaging and invasive studies (including aspirations and biopsies) were also recorded. Fourteen patients (58%) had renal involvement, with WHO class 4 and 5 comprising 89% of the cases. Eight patients (33%) had neurological involvement. Out of these 8 patients, 3 presented with psychosis (12.5%) and 4 (17%) with seizures. Twenty three patients (96%) had hematological involvement, 6 (25%) had serosal and 10 (41%) had articular involvement. Cutaneous lesions were noted in 10 (41%) patients. A majority of the patients were noncompliant and were lost to follow-up; therefore, ultimate outcome could not be clearly delineated. A high index of suspicion for SLE in males may permit early diagnosis and dictate the need for more aggressive therapy.
Rabbani
Malik Anas
MA
Department of Medicine, Aga Khan University Hospital, Karachi.
Ahmad
Bushra
B
Shah
Syed Mansoor Ahmed
SM
Mekan
Sabeen Fatima
SF
Ali
Syed Sohail
SS
Ahmed
Aasim
A
D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D000974:Antibodies, Antinuclear / Q000097:blood; D017152:Antibodies, Antiphospholipid / Q000097:blood; D001772:Blood Cell Count; D001799:Blood Sedimentation; D002490:Central Nervous System / Q000473:pathology; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood; D004573:Electrolytes / Q000097:blood; D005500:Follow-Up Studies; D006761:Hospitals; D006801:Humans; D007668:Kidney / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology / Q000473:pathology*; D008297:Male; D010154:Pakistan
D019268:Antibodies, Antineutrophil Cytoplasmic; D000974:Antibodies, Antinuclear; D017152:Antibodies, Antiphospholipid; D004573:Electrolytes; D003404:Creatinine