title: Risk factors associated with Coccidioides infection in dogs.
abstract: OBJECTIVE
  To evaluate potential risk factors for Coccidioides infection among dogs living in a region in which the organism is endemic (Pima and Maricopa counties, Arizona).
  
  
  METHODS
  Community-based longitudinal and cross-sectional studies.
  
  
  METHODS
  104 healthy 4- to 6-month-old puppies (longitudinal study) and 381 4- to 18-month-old dogs with unknown serostatus (cross-sectional study).
  
  
  METHODS
  Dogs in the longitudinal study were tested 3 times at 6-month intervals for anticoccidioidal antibodies; dogs in the cross-sectional study were tested only once. Owners of all dogs completed a questionnaire on potential environmental exposures.
  
  
  RESULTS
  In the longitudinal study, the relative risk of infection for dogs that were outdoors during the day was 4.9 times the risk for dogs that were kept indoors. Seropositive dogs in the cross-sectional study were 6.2 times as likely to have access to > 1 acre to roam as were seronegative dogs. Logistic regression analysis indicated that the odds of infection increased with age (odds ratio [OR], 1.1), amount of roaming space (OR, 2.4), and walking in the desert (OR, 2.2). Walking on sidewalks had a protective effect (OR, 0.4).
  
  
  CONCLUSIONS
  Results suggest that in regions in which the organism is endemic, dogs that spend more time outdoors or have more land in which to roam are at greater risk of infection with Coccidioides spp.
authors.affiliation: Department of Veterinary Science and Microbiology, University of Arizona, Tucson, AZ 85721, USA.
authors.forename: Christine D
authors.initials: CD
authors.lastname: Butkiewicz
authors.forename: Lisa E
authors.initials: LE
authors.lastname: Shubitz
authors.forename: Sharon M
authors.initials: SM
authors.lastname: Dial
mesh_terms: D000367:Age Factors; D000822:Animal Husbandry / Q000379:methods*; D000818:Animals; D000908:Antibodies, Fungal / Q000097:blood; D003045:Coccidioides / Q000276:immunology*; D003047:Coccidioidomycosis / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D004283:Dog Diseases / Q000453:epidemiology* / Q000473:pathology; D004285:Dogs; D005260:Female; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D016017:Odds Ratio; D012307:Risk Factors
chemical_list: D000908:Antibodies, Fungal