title: In vitro inhibitory effects of hinokitiol on proliferation of Chlamydia trachomatis.
abstract: The inhibitory effects of hinokitiol (beta-thujaplicin) on Chlamydia trachomatis D/UW-3/Cx were shown by MIC, minimum lethal concentration (MLC), and preinoculation minimal microbicidal concentration assays using HeLa 229 cells. The MIC and the MLC were both 32 microg/ml. Further evaluation of hinokitiol as a topical agent against C. trachomatis is warranted.
authors.affiliation: Department of Virology 1, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo, Japan 162-8640.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Yamano
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yamazaki
authors.forename: Kozue
authors.initials: K
authors.lastname: Sato
authors.forename: Sadashi
authors.initials: S
authors.lastname: Shiga
authors.forename: Toshikatsu
authors.initials: T
authors.lastname: Hagiwara
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Ouchi
authors.forename: Toshio
authors.initials: T
authors.lastname: Kishimoto
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000633:toxicity; D002692:Chlamydia trachomatis / Q000187:drug effects* / Q000254:growth & development*; D004305:Dose-Response Relationship, Drug; D006367:HeLa Cells / Q000187:drug effects / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D039821:Monoterpenes / Q000494:pharmacology* / Q000633:toxicity; D014334:Tropolone / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D000890:Anti-Infective Agents; D039821:Monoterpenes; D014334:Tropolone; C009479:beta-thujaplicin