Inhibition of farnesyl protein transferase--a review of the recent patent literature.
The inhibition of farnesyl protein transferase (FPT) has been the subject of intense research over the last few years and offers a promising approach to non-cytotoxic, anticancer therapy. Several FPT inhibitors are currently in clinical trials for anticancer therapy. This paper reviews the patent applications that appeared from January to July 2001. A brief summary of the compounds in clinical evaluation is also given.
Doll
R J
RJ
Department of Chemical Research-Infectious Diseases and Tumor Biology, Schering-Plough Research Institute, 2015 Galloping Hill Rd, Kenilworth, NJ 07033-1300, USA. ronald.doll@spcorp.com