Analysis of quantitative data obtained from toxicity studies showing non-normal distribution.
The data obtained from toxicity studies are examined for homogeneity of variance, but, usually, they are not examined for normal distribution. In this study I examined the measured items of a carcinogenicity/chronic toxicity study with rats for both homogeneity of variance and normal distribution. It was observed that a lot of hematology and biochemistry items showed non-normal distribution. For testing normal distribution of the data obtained from toxicity studies, the data of the concurrent control group may be examined, and for the data that show a non-normal distribution, non-parametric tests with robustness may be applied.
Kobayashi
Katsumi
K
An-Pyo Center, Shizuoka, Japan.
D000818:Animals; D008297:Male; D016011:Normal Distribution; D051381:Rats; D011916:Rats, Inbred F344; D018675:Toxicity Tests