[Extranodal Rosai-Dorfman disease].
OBJECTIVE
To investigate the diagnosis and differential diagnosis of extranodal Rosai-Dorfman disease.


METHODS
Two cases of extranodal Rosai-Dorfman disease were studied using hematoxylin-eosin, and immunohistochemical staining, along with a literature review.


RESULTS
The lesions of RDD were characterized by the presence of large histiocytes with emperipolesis, accompanied by infiltration of lymphocytes, plasma cells and other inflammatory cells. The large histiocytes had an abundant cytoplasm, pale to eosinophilic in appearance, positive for S-100 protein staining, with a vesicular nucleus and a small basophilic nucleolus in each cell.


CONCLUSIONS
Extranodal Rosai-Dorfman disease is known as an idiopathic proliferative disease of histiocytes with a distinct morphologic feature and is very rare. Differential diagnosis from other types of fibrohistiocytic proliferation lesions is recommended.
Gan
Mei-fu
MF
Department of pathology, Taizhou Hospital of Zhejiang Province, Linhai 317000, China. gmeifu@sohu.com
Zhou
Tao
T
Yu
Xin-ru
XR
Yu
Chun-kai
CK
Zheng
Hai-hong
HH
Cai
Ju-fang
JF
D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D001921:Brain / Q000473:pathology / Q000601:surgery; D001927:Brain Diseases / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D062109:Dermatologic Surgical Procedures; D003937:Diagnosis, Differential; D015618:Histiocytosis, Sinus / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009418:S100 Proteins / Q000378:metabolism; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D009418:S100 Proteins; C067980:CD68 antigen, human; D000097382:CD68 Molecule