Efficacy of desmopressin in patients with multiple sclerosis suffering from bladder dysfunction: a meta-analysis.
OBJECTIVE
The current review evaluates the safety and efficacy of desmopressin in patients with multiple sclerosis (MS) who suffer from both daytime and nocturnal voiding frequency and from incontinence.


METHODS
A literature search was carried out looking for studies published between 1990 and 2003 which evaluated desmopressin in MS patients with bladder dysfunction.


RESULTS
The grand total mean effect sizes show the following estimates of clinical relevant differences: desmopressin has a moderate effect on the number of voids during the day or during the night over a period of 6 h after taking the drug. A large effect associated with the use of desmopressin was detected by the mean difference in urine volume (ml) in 6 h. A small effect was detected in the mean 24-h urine volume. Serum sodium levels were combined with plasma osmolality in some studies and were found to be not significantly affected by desmopressin treatment.
Bosma
R
R
Department of Health Sciences, Faculty of Medical Sciences, University Medical Center Groningen, Groningen, The Netherlands.
Wynia
K
K
Havlíková
E
E
De Keyser
J
J
Middel
Berrie
B
D000328:Adult; D000368:Aged; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000503:physiopathology; D009994:Osmolar Concentration; D012076:Renal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D012964:Sodium / Q000097:blood; D016896:Treatment Outcome; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology; D014554:Urination / Q000187:drug effects / Q000502:physiology; D014882:Water-Electrolyte Balance / Q000187:drug effects / Q000502:physiology
D012076:Renal Agents; D012964:Sodium; D003894:Deamino Arginine Vasopressin