Familial hypertensive intracerebral hemorrhage and autosomal dominant polycystic kidney disease.
Autosomal dominant polycystic kidney disease (ADPKD) is a generalized disease known to be associated with intracranial aneurysms. Non-aneurysmal intracerebral hemorrhage (ICH) has also been reported in ADPKD. We report a familial clustering of ICH and symptomatic ADPKD. This pedigree had at least six affected family members who suffered from ADPKD, hypertension and non-aneurysmal ICH. The proband demonstrated ADPKD, hypertension and cerebral hemorrhage. To our knowledge, this is the first report of familial ICH in ADPKD, which may have underlying genetic and environmental etiologies.
Lin
Tien-Jen
TJ
Division of Neurosurgery, Department of Surgery, Municipal Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Hwang
Fu-Chao
FC
Chen
Chien-Jen
CJ
Chiu
Wen-Ta
WT
Chang
Cheng-Kuei
CK
D000328:Adult; D005192:Family Health; D005260:Female; D006801:Humans; D020299:Intracranial Hemorrhage, Hypertensive / Q000150:complications* / Q000235:genetics / Q000473:pathology; D007668:Kidney / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications* / Q000235:genetics / Q000473:pathology; D014463:Ultrasonography / Q000379:methods