title: Novel molecular drug carrier: encapsulation of oxaliplatin in cucurbit[7]uril and its effects on stability and reactivity of the drug.
abstract: Oxaliplatin forms a stable 1:1 inclusion complex with cucurbit[7]uril as indicated by NMR, mass spectrometry, isothermal titration calorimetry and X-ray crystallography. The encapsulation of the drug results in a large enhancement in stability, a moderate decrease in reactivity toward guanosine but a much larger decrease in reactivity toward L-methionine, which suggests the encapsulation not only increases the stability of the drug but also may reduce unwanted side effects caused by protein binding of the platinum drug. A preliminary in vitro assay using various tumor cell lines reveals that the encapsulation results in a decrease in the antitumor activity of oxaliplatin.
authors.affiliation: National Creative Research Initiative Center for Smart Supramolecules, Division of Molecular and Life Sciences, Pohang University of Science and Technology San 31 Hyojadong, Pohang 790-784, Republic of Korea.
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Jeon
authors.forename: Soo-Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Ko
authors.forename: Shigeru
authors.initials: S
authors.lastname: Sakamoto
authors.forename: Kentaro
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Kimoon
authors.initials: K
authors.lastname: Kim
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D001952:Bridged-Ring Compounds / Q000737:chemistry*; D002151:Calorimetry; D018360:Crystallography, X-Ray; D004337:Drug Carriers; D004355:Drug Stability; D006151:Guanosine / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008715:Methionine / Q000737:chemistry; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000494:pharmacology; D000077150:Oxaliplatin; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
chemical_list: D000970:Antineoplastic Agents; D001952:Bridged-Ring Compounds; D004337:Drug Carriers; D006151:Guanosine; D007093:Imidazoles; D008715:Methionine; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; C456276:cucurbit(7)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils