title: The effects of intravenous lidocaine on pain during injection of medium- and long-chain triglyceride propofol emulsions.
abstract: Propofol formulated in medium- and long-chain triglycerides (MCT/LCT) is thought to cause less pain on injection. In this study we sought to determine if adding lidocaine to propofol-MCT/LCT is more effective in decreasing pain compared with propofol-MCT/LCT alone or conventional propofol-lidocaine mixtures. Seventy-five patients were randomized into three groups. Group A received conventional propofol-lidocaine mixtures with 20 mg lidocaine, group B received propofol-MCT/LCT with saline, and group C received propofol-MCT/LCT with 20 mg lidocaine. The incidence of pain was 24% in groups A and B and 4% in group C. The number needed to treat to prevent pain was 5. We conclude that propofol-MCT/LCT-lidocaine mixtures significantly reduce pain.
authors.affiliation: Department of Anaesthesia and Surgical Intensive Care, Singapore General Hospital, Singapore.
authors.forename: Woon Si
authors.initials: WS
authors.lastname: Yew
authors.forename: Shin Yuet
authors.initials: SY
authors.lastname: Chong
authors.forename: Kian Hian
authors.initials: KH
authors.lastname: Tan
authors.forename: Meng Huat
authors.initials: MH
authors.lastname: Goh
mesh_terms: D000293:Adolescent; D000328:Adult; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects*; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000627:therapeutic use*; D004311:Double-Blind Method; D004655:Emulsions; D005079:Excipients; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008012:Lidocaine / Q000008:administration & dosage* / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000139:chemically induced* / Q000188:drug therapy*; D010147:Pain Measurement / Q000187:drug effects; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects*; D014280:Triglycerides
chemical_list: D018686:Anesthetics, Intravenous; D000779:Anesthetics, Local; D004655:Emulsions; D005079:Excipients; D014280:Triglycerides; D008012:Lidocaine; D015742:Propofol