title: [Aging study of event-related potential on visual spatial attention precued by Chinese words].
abstract: OBJECTIVE
  Based on the visual experimental paradigm "precue-target", the search range should be affected by different Chinese characters and the dynamic mechanisms of aging in the brain on the visual attention were investigated.
  
  
  METHODS
  16 young and 16 old subjects participated the experiment. Cue was comprised of three Chinese words "Large", or "Median" or "Small." The letter "T" was designed as the target stimulus. When the cue was the "large", "T" may appear within 3 circles. When the cue was the "median", "T" may appear within either the median and small circles. When the cue was small, the target "T" may appear only within the small circle.
  
  
  RESULTS
  The reaction time (RT) of the two groups of subjects became quick with the reduction of the cue size, while amplitudes of the P1 and N1 component of ERPs increased with the decrease of the cue scale. Old subjects showed longer RT than younger subjects did. The posterior P1 was enhanced significantly and the N1 was inhibited obviously in the old group. The P2 was manifested as significantly inhibitory effect not only in the amplitude but also in the abnormal and unstable waveform.
  
  
  CONCLUSIONS
  The cognitive function of elderly subjects declined in the task of visual spatial attention. We demonstrated for the first time that the P2 was manifested as significantly inhibitory effect, which suggested that the age-related reduction could lead to dysfunction in the anterior scalp to visual spatial attention (voluntary attention).
authors.forename: Wei-qun
authors.initials: WQ
authors.lastname: Song
authors.forename: Wei-ming
authors.initials: WM
authors.lastname: Song
authors.forename: Yue-jia
authors.initials: YJ
authors.lastname: Luo
authors.forename: Feng
authors.initials: F
authors.lastname: Ling
authors.forename: Mao-bin
authors.initials: MB
authors.lastname: Wang
authors.forename: Yan-jing
authors.initials: YJ
authors.lastname: Qin
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D001288:Attention / Q000502:physiology*; D003463:Cues; D004569:Electroencephalography; D005074:Evoked Potentials, Visual / Q000502:physiology*; D006801:Humans; D011930:Reaction Time / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*