title: Presynaptic calcium stores and synaptic transmission.
abstract: Following the gradual recognition of the importance of intracellular calcium stores for somatodendritic signaling in the mammalian brain, recent reports have also indicated a significant role of presynaptic calcium stores. Ryanodine-sensitive stores generate local, random calcium signals that shape spontaneous transmitter release. They amplify spike-driven calcium signals in presynaptic terminals, and consequently enhance the efficacy of transmitter release. They appear to be recruited by an association with certain types of calcium-permeant ion channels, and they induce specific forms of synaptic plasticity. Recent research also indicates a role of inositoltrisphosphate-sensitive presynaptic calcium stores in synaptic plasticity.
authors.affiliation: CNRS UMR8118, Laboratoire de Physiologie Cérébrale, UFR Biomédicale, Université Paris 5, 45 rue des Saints Pères, 75006 Paris, France.
authors.forename: Thibault
authors.initials: T
authors.lastname: Collin
authors.forename: Alain
authors.initials: A
authors.lastname: Marty
authors.forename: Isabel
authors.initials: I
authors.lastname: Llano
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D017774:Long-Term Potentiation / Q000502:physiology; D008959:Models, Neurological; D018377:Neurotransmitter Agents / Q000378:metabolism; D017729:Presynaptic Terminals / Q000378:metabolism*; D012433:Ryanodine / Q000378:metabolism; D019837:Ryanodine Receptor Calcium Release Channel / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D018377:Neurotransmitter Agents; D019837:Ryanodine Receptor Calcium Release Channel; D012433:Ryanodine; D002118:Calcium