Synthesis and characterization of the monomer ruthenium complex of hypocrellin B.
We first synthesized and characterized a monomer ruthenium complex of hypocrellin B (HB) by chelation with Ru(bpy)2Cl2 (in which bpy=2,2'-bipyridine). It possesses the photosensitizing properties and can be applied in photodynamic therapy (PDT). The chemiluminescence assays indicated that the photodamage ability of the complex is stronger than that of HB.
Zhou
Jiahong
J
Analysis and Testing Center, Nanjing Normal University, Nanjing 210097, China. zhoujiahong72@hotmail.com
Liu
Jihua
J
Feng
Yuying
Y
Wei
Shaohua
S
Gu
Xiaotian
X
Wang
Xuesong
X
Zhang
Baowen
B
D000818:Animals; D002417:Cattle; D004247:DNA / Q000378:metabolism*; D015394:Molecular Structure; D010569:Perylene / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D011809:Quinones / Q000138:chemical synthesis* / Q000494:pharmacology*; D017975:Ruthenium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*
D017319:Photosensitizing Agents; D011809:Quinones; D017975:Ruthenium Compounds; D010569:Perylene; D004247:DNA; C064522:hypocrellin B