title: Patient online self-reporting of toxicity symptoms during chemotherapy.
abstract: OBJECTIVE
  Tracking symptoms related to treatment toxicity is standard practice in routine care and during clinical trials. Currently, clinicians collect symptom information via complex and often inefficient mechanisms, but there is growing interest in collecting outcome information directly from patients.
  
  
  METHODS
  The National Cancer Institute Common Terminology Criteria for Adverse Events schema for seven common symptoms was adapted into a Web-based patient-reporting system, accessible from desktop computers in outpatient clinics and from home computers. Eighty patients with gynecologic malignancies beginning standard chemotherapy regimens were enrolled between April and September 2004. During an 8-week observation period, participants were encouraged to log in and report symptoms at each follow-up visit, or alternatively, to access the system from home.
  
  
  RESULTS
  All patients completed an initial log in. At each subsequent appointment, most enrollees (80% to 85%) reported symptoms using the online system, with a mean of three follow-up visits per patient during the observation period (range, one to six). Sixty of 80 patients (75%) logged in at least once from home. Use was significantly associated with prior Internet experience. Forty-two severe toxicities (grade 3 to 4) entered from home prompted seven clinician interventions. Most patients (96%) found the system useful and would recommend it to others.
  
  
  CONCLUSIONS
  Patients are capable of reporting symptoms experienced during chemotherapy using a Web-based interface. Assessment in the clinical trial setting and comparison of direct patient- versus clinician-based approaches for reporting symptoms and their severity are warranted.
authors.affiliation: Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, 307 E 63rd St, New York, NY 10021, USA. basche@mskcc.org
authors.forename: Ethan
authors.initials: E
authors.lastname: Basch
authors.forename: David
authors.initials: D
authors.lastname: Artz
authors.forename: Dorothy
authors.initials: D
authors.lastname: Dulko
authors.forename: Kevin
authors.initials: K
authors.lastname: Scher
authors.forename: Paul
authors.initials: P
authors.lastname: Sabbatini
authors.forename: Martee
authors.initials: M
authors.lastname: Hensley
authors.forename: Nandita
authors.initials: N
authors.lastname: Mitra
authors.forename: John
authors.initials: J
authors.lastname: Speakman
authors.forename: Mary
authors.initials: M
authors.lastname: McCabe
authors.forename: Deborah
authors.initials: D
authors.lastname: Schrag
mesh_terms: D000293:Adolescent; D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use / Q000633:toxicity*; D015331:Cohort Studies; D064420:Drug-Related Side Effects and Adverse Reactions; D005240:Feasibility Studies; D005260:Female; D005833:Genital Neoplasms, Female / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D020407:Internet; D008875:Middle Aged; D009862:Online Systems; D010358:Patient Participation; D012680:Sensitivity and Specificity; D014481:United States