title: Invasive and non-invasive diagnosis of Helicobacter pylori-associated atrophic gastritis: a comparative study.
abstract: OBJECTIVE
  Helicobacter pylori-associated atrophic gastritis is known to be a significant risk factor for gastric cancer. Among the well-known parameters of atrophic gastritis are the levels of serum gastrin-17 (G-17) and pepsinogen I (PG1), which are biomarkers of gastric antral and corpus mucosal activity, respectively. The aim of study was to compare the production of G-17 and PG1 in patients with or without stomach mucosal atrophy and to investigate the utility of serum PG1 and/or G-17 concentrations for the objective evaluation of atrophic gastritis.
  
  
  METHODS
  A total of 178 dyspeptic Helicobacter pylori-positive patients underwent diagnostic upper gastrointestinal endoscopy with biopsy. The degree of histologic gastric mucosal atrophy was compared with the fasting levels of PG1, and to the postprandial levels of G-17 detected by enzyme immunoassay.
  
  
  RESULTS
  A decrease in serum G-17 levels along with worsening of the antral atrophy was observed; the serum levels of PG1 were reduced during progression of the corpus atrophy. In the multifocal atrophic gastritis, values for PG1 and G-17 serum concentrations were significantly lower than the respective cut-off values. Statistical analysis revealed statistically significant differences between the serum levels of PG1 and G-17 measured at different stages of stomach mucosal atrophy.
  
  
  CONCLUSIONS
  A strong reverse correlation was found between histologic/ endoscopic antral atrophy and serum G-17 levels, and between corpus atrophy and serum PG1 levels.
authors.affiliation: Department of Therapy, Stavropol Medical Academy, Stavropol, Russia. passetchnikov@mail.ru
authors.forename: Victor D
authors.initials: VD
authors.lastname: Pasechnikov
authors.forename: Sergey Z
authors.initials: SZ
authors.lastname: Chukov
authors.forename: Sergey M
authors.initials: SM
authors.lastname: Kotelevets
authors.forename: Alexander N
authors.initials: AN
authors.lastname: Mostovov
authors.forename: Varvara P
authors.initials: VP
authors.lastname: Mernova
authors.forename: Maria B
authors.initials: MB
authors.lastname: Polyakova
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001706:Biopsy / Q000379:methods; D016145:Endoscopy, Digestive System; D005753:Gastric Mucosa / Q000473:pathology; D005755:Gastrins / Q000097:blood; D005757:Gastritis, Atrophic / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D016481:Helicobacter Infections / Q000150:complications* / Q000175:diagnosis / Q000382:microbiology; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D020116:Pepsinogen A / Q000097:blood; D011706:Pyloric Antrum / Q000473:pathology*; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
chemical_list: D000907:Antibodies, Bacterial; D015415:Biomarkers; D005755:Gastrins; C013550:gastrin 17; D020116:Pepsinogen A