Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?
Relative to other neutral amino acid transporters, the expression levels of ASCT2 and LAT1, are coordinately elevated in a wide spectrum of primary human cancers, suggesting that they are frequently co-opted to support the "tumor metabolome". Each has recently been shown to play important roles in the growth and survival of cancer cell lines, making them potential targets for cancer therapy. The properties and putative relationship of these two amino acid exchangers are discussed in the context of their demonstrated utility in cancer biology, including cellular growth and survival signaling and integrated links to the mammalian target-of-rapamycin (mTOR) kinase.
Fuchs
Bryan C
BC
Department of Biology, Saint Louis University, MW128, 3507 Laclede Avenue, St. Louis, MO 63103-2010, USA.
Bode
Barrie P
BP
D026962:Amino Acid Transport System ASC / Q000378:metabolism*; D001692:Biological Transport; D006801:Humans; D027283:Large Neutral Amino Acid-Transporter 1 / Q000378:metabolism*; D015778:Minor Histocompatibility Antigens; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D011494:Protein Kinases / Q000378:metabolism; D058570:TOR Serine-Threonine Kinases
D026962:Amino Acid Transport System ASC; D027283:Large Neutral Amino Acid-Transporter 1; D015778:Minor Histocompatibility Antigens; C420506:SLC1A5 protein, human; D011494:Protein Kinases; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases