[Aminoguanidin improves learning process in neonatal rats exposed to hypoxia-ischemia].
Seven-day-old rats (n = 40) were divided into five groups (8 pups in each of them). They were exposed to unilateral common carotid artery ligation, 2-3 h later followed by 2,5 h hypoxia (8% oxygen in 92% nitrogen) at 37 degrees C and immediately after insult once a day during three days received i/p injection of aminoguanidin (150 mg/kg) (group 1). Group 2 underwent procedures similar to the first group but received i/p injection of 300 mg/kg aminoguanidin. Group 3 instead of aminoguanidin received the same amount of saline. Group 4 composed by false-operated pups and Group 5--by intact pups. 22 days after hypoxic-ischemic exposure pups underwent 12 day learning test in multi-way maze. Process of learning in hypoxia-ischemic pups (group 3) were essentially deteriorated in comparison with false-operated and intact pups, but in groups were animals received aminoguanidin process of learning was close to control rats.
Khurtsia
M
M
I. Beritashvili Institute of Physiology, Georgian Academy of Sciences.
Zananian
I
I
Pavlenishvili
I
I
Bekaia
G
G
D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal; D004195:Disease Models, Animal; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D006146:Guanidines / Q000008:administration & dosage / Q000627:therapeutic use*; D020925:Hypoxia-Ischemia, Brain / Q000188:drug therapy* / Q000523:psychology; D007274:Injections, Intraperitoneal; D018782:Maze Learning / Q000187:drug effects*; D051381:Rats
D004791:Enzyme Inhibitors; D006146:Guanidines; C004479:pimagedine