Naip5/Birc1e and susceptibility to Legionella pneumophila.
Genetic analysis in mice is a powerful approach for the identification of genes and proteins that have a key role at the interface of the host-pathogen interaction. The Lgn1 locus has been found to control the intracellular replication of Legionella pneumophila in murine macrophages. Using functional complementation in transgenic mice, the Naip5/Birc1e gene has been identified as responsible for the Lgn1 effect. The classification of Naip5/Birc1e as a member of the NLR protein family suggests that Naip5/Birc1e acts as an intracellular sensor of L. pneumophila. The nature of the signal transduced by Naip5/Birc1e in response to Legionella products is of great interest but is currently unknown. Here, several possible scenarios are presented.
Fortier
Anne
A
Department of Biochemistry and Center for the Study of Host Resistance, McGill University, 3655 Sir William Osler Promenade, Montreal, Quebec, Canada, H3G 1Y6.
Diez
Eduardo
E
Gros
Philippe
P
D000818:Animals; D004198:Disease Susceptibility; D016952:Legionella pneumophila / Q000254:growth & development* / Q000276:immunology; D007877:Legionnaires' Disease / Q000235:genetics / Q000276:immunology* / Q000382:microbiology*; D008264:Macrophages / Q000276:immunology / Q000382:microbiology*; D051379:Mice; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology*; D051616:Neuronal Apoptosis-Inhibitory Protein
C496806:Naip5 protein, mouse; D009419:Nerve Tissue Proteins; D051616:Neuronal Apoptosis-Inhibitory Protein