Lymphoepithelial carcinoma of the larynx.
Lymphoepithelial carcinoma (LEC) of the larynx is a rare neoplasm; with a review of the literature having disclosed only 34 documented cases. This neoplasm seems to behave in a fashion reminiscent of nasopharyngeal carcinoma. In contrast to nasopharyngeal carcinoma, most cases have not been associated with Epstein-Barr virus (EBV). The diagnosis often requires immunohistochemistry or electron microscopy for confirmation. We describe a case of this tumor involving the supraglottis. The patient was treated with supraglottic laryngectomy and bilateral modified neck dissection. The histopathological study of the surgical specimen revealed an undifferentiated carcinoma with aspects of lymphoeptihelioma. The patient underwent radiotherapy and his 2-year follow-up showed no evidence of local or distant metastasis.
Coskun
Berna Uslu
BU
Department of Otolaryngology, Sisli Etfal Training and Research Hospital, Adnan Saygun Cad. Kelaynak Sok., Kibele Sitesi 10/1 Ulus 34340, Istanbul, Turkey. bernauslu@tnn.net
Cinar
Ugur
U
Sener
Belit Merve
BM
Dadas
Burhan
B
D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000532:radiotherapy / Q000601:surgery; D004724:Endoscopy; D005931:Glottis; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy / Q000601:surgery; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D018714:Radiotherapy, Adjuvant; D013194:Staining and Labeling; D014057:Tomography, X-Ray Computed