[Impact of Ph-SA on the expression of delta-toxin in Staphylococcus aureus].
OBJECTIVE
We carried out this pilot study in an attempt to observe the effect of Ph-SA on the secretion of delta-toxin in S. aureus ATCC29213.


METHODS
When A595 reaching about 0. 2, the bacteria were divided into three groups and were treated by PBS, penicillin and Ph-SA respectively. The amount of delta-toxin from different groups and growth phases was analyzed by high performance liquid chromatography.


RESULTS
It was observed that the secretion of delta-toxin in Ph-SA group was less than that in the other two groups at the same time (P < 0.05).


CONCLUSIONS
We postulate that Ph-SA has the negative effect on the activity of agr system, acting as a pseudo-ligand.
Guo
Li
L
Laboratory of Transplant Engineering and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.
Zhang
Jie
J
Tang
Xiao-yan
XY
Qiu
Xiao-qing
XQ
D001426:Bacterial Proteins / Q000235:genetics* / Q000494:pharmacology*; D001427:Bacterial Toxins / Q000096:biosynthesis*; D006801:Humans; D010675:Pheromones / Q000235:genetics / Q000494:pharmacology*; D010865:Pilot Projects; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000378:metabolism; D015534:Trans-Activators / Q000235:genetics* / Q000494:pharmacology*
C095698:Agr protein, Staphylococcus aureus; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D010675:Pheromones; D015534:Trans-Activators; C025971:staphylococcal delta toxin