Reduced plasma levels of NGF and BDNF in patients with acute coronary syndromes.
To test the hypothesis that neurotrophins might undergo significant changes in acute coronary syndrome (ACS), NGF and BDNF levels in sera of patients suffering of ACS and in control subjects were measured by enzyme-linked immunosorbent assay (ELISA). Plasma concentrations of glucose, total cholesterol, triglycerides, LDL, HDL, creatin kinase (CK), MB isoenzyme CK (CK-MB) were also measured with routine laboratory methods. We found reduced plasma levels of both NGF and BDNF in patients with ACS. These observations supports the hypothesis that one or both of these neurotrophins may be implicated in the pathogenesis of human coronary atherosclerosis.
Manni
Luigi
L
Nikolova
Vesselka
V
Vyagova
Diana
D
Chaldakov
George N
GN
Aloe
Luigi
L
D000208:Acute Disease; D015415:Biomarkers / Q000097:blood; D019208:Brain-Derived Neurotrophic Factor / Q000172:deficiency*; D003327:Coronary Disease / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008297:Male; D020932:Nerve Growth Factor / Q000172:deficiency*; D011379:Prognosis; D012720:Severity of Illness Index
D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; D020932:Nerve Growth Factor