Validity of plasma aldosterone-to-renin activity ratio in African American and white subjects with resistant hypertension.
BACKGROUND
Recent reports suggesting that primary aldosteronism (PA) is more common than historically thought have often relied on use of the plasma aldosterone concentration (PAC) to plasma renin activity (PRA) ratio (ARR) to identify patients with PA. Prior determinations of the validity of the ARR had been generally limited to subjects that could be withdrawn from antihypertensive therapy and to non-African American subjects.


RESULTS
The current study was designed to evaluate prospectively the diagnostic value of the ARR in treated African American and white subjects with resistant hypertension. Consecutive subjects referred to a university hypertension clinic for resistant hypertension were evaluated with an early morning ARR and a 24-h urinary aldosterone and sodium. The presence of PA was defined as a suppressed PRA (<1.0 ng/mL/h) and elevated urinary aldosterone excretion (>12 microg/24 h) during high dietary sodium ingestion (>200 mEq/24 h). In 58 subjects, PA was confirmed. The ARR was elevated (>20) in 45 of 58 subjects with PA and in 35 of the 207 patients without PA, resulting in a sensitivity of 78% and specificity of 83% with a corresponding positive predictive value of 56% and a negative predictive value of 93%. Among African American subjects, the ARR was less sensitive than in white subjects (75% v 80%), but it still had a high negative predictive value (92% v 94%).


CONCLUSIONS
These data indicate that the ARR is valid as a screening test for PA in African American and white patients on stable antihypertensive treatments, but a high percentage of false-positive results precludes using it for accurate diagnosis of PA.
Nishizaka
Mari K
MK
Vascular Biology and Hypertension Program, University of Alabama at Birmingham, Birmingham, Alabama, USA. marikn@uab.edu
Pratt-Ubunama
Monique
M
Zaman
Mohammad A
MA
Cofield
Stacey
S
Calhoun
David A
DA
D001741:Black or African American; D000407:Alabama / Q000208:ethnology; D000450:Aldosterone / Q000097:blood* / Q000652:urine; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001794:Blood Pressure; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood / Q000150:complications / Q000208:ethnology; D006973:Hypertension / Q000097:blood* / Q000208:ethnology / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011863:Radioimmunoassay; D012083:Renin / Q000097:blood*; D015203:Reproducibility of Results; D012307:Risk Factors; D012964:Sodium / Q000652:urine; D044465:White People
D015415:Biomarkers; D000450:Aldosterone; D012964:Sodium; D012083:Renin