Effect of 1-butanol on the microstructure of lecithin/water/tripalmitin system.
Warm microemulsions based on lipids characterized by a melting point over 50 degrees C have been successfully used as starting matrix in a quenching process to obtain solid lipid nanoparticles (SLN). In this work, we have investigated the effect of 1-butanol (B) on the phase behavior of the lecithin (LCT)/water (W)/tripalmitin (TP) system at 70 degrees C. The study has been carried out at LCT/B=1 (weight ratio). Emulsion and liquid crystalline phase regions have been observed in the ternary phase diagram, while the presence of 1-butanol in the LCT/W/B/TP system allows the formation of a wide area of liquid isotropic phase from the whole (LCT+B)/TP binary axis up to 37 wt% of water. The microstructure of this isotropic phase has been investigated by means of 1H NMR PGSE technique. The self-diffusion coefficients of the different components along oil and water dilution lines indicate a microstructural organization characterized by a highly connected water in oil domains.
Caboi
Francesca
F
Dipartimento Scienze Chimiche, CSGI Università di Cagliari, S.S. 554 Bivio Sestu, 09042 Monserrato, CA, Italy.
Lazzari
Paolo
P
Pani
Luca
L
Monduzzi
Maura
M
D020001:1-Butanol / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D004655:Emulsions / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D049329:Nanostructures; D044367:Phase Transition; D010713:Phosphatidylcholines / Q000737:chemistry*; D013696:Temperature; D014280:Triglycerides / Q000737:chemistry*; D014867:Water
D004337:Drug Carriers; D004655:Emulsions; D010713:Phosphatidylcholines; D014280:Triglycerides; D014867:Water; D020001:1-Butanol; C005859:tripalmitin