Flow-through chloroquine sensor and its applications in pharmaceutical analysis.
Poly (vinyl chloride) membrane electrodes that responded selectively towards the antimalarial drug chloroquine are described. The electrodes were based on the use of the lipophilic potassium tetrakis(4-chlorophenyl)borate as ion-exchanger and bis(2-ethylhexyl)adipate (BEHA), or trioctylphosphate (TOP) or dioctylphenylphosphonate (DOPP) as plasticizing solvent mediator. All electrodes produced good quality characteristics such as Nernstian- and rapid responses, and are minimally interfered with by the alkali and alkaline earth metal ions tested. The membranes were next applied to a flow-through device, enabling it to function as flow-injection analysis (FIA) detector. The performance of the sensor after undergoing the FIA optimization was further evaluated for its selectivity characteristics and lifetime. Results for the determination of chloroquine in synthetic samples that contained common tablet excipients such as glucose, starch, and cellulose, and other foreign species such as cations, citric acid or lactic acid were generally satisfactory. The sensor was also successfully used for the determination of the active ingredients in mock tablets, synthetic fluids and biological fluids. The sensor was applied for the determination of active ingredients and the dissolution profile of commercial tablets was also established.
Saad
Bahruddin
B
School of Chemical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia. bahrud@usm.my
Zin
Zainiharyati Mohd
ZM
Jab
Md Sariff
MS
Rahman
Ismail Ab
IA
Saleh
Muhammad Idiris
MI
Mahsufi
Shariff
S
D000962:Antimalarials / Q000032:analysis*; D002738:Chloroquine / Q000032:analysis*; D004566:Electrodes; D017022:Flow Injection Analysis; D007202:Indicators and Reagents; D010968:Plasticizers; D011786:Quality Control; D012995:Solubility; D012996:Solutions; D013607:Tablets
D000962:Antimalarials; D007202:Indicators and Reagents; D010968:Plasticizers; D012996:Solutions; D013607:Tablets; D002738:Chloroquine