Linkage disequilibrium maps and association mapping.
The causal chain between a gene and its effect on disease susceptibility cannot be understood until the effect has been localized in the DNA sequence. Recently, polymorphisms incorporated in the HapMap Project have made linkage disequilibrium (LD) the most powerful tool for localization. The genetics of LD, the maps and databases that it provides, and their use for association mapping, as well as alternative methods for gene localization, are briefly described.
Morton
Newton E
NE
Human Genetics Division, Southampton General Hospital, Southampton, United Kingdom. nem@soton.ac.uk
D030541:Databases, Genetic; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D015810:Linkage Disequilibrium; D020161:Physical Chromosome Mapping / Q000379:methods; D020641:Polymorphism, Single Nucleotide