Highly enantioselective copper(I)-phosphoramidite-catalysed additions of organoaluminium reagents to enones.
Simple phosphoramidite ligands afford good to excellent levels of enantioselectivity in 1,4-additions of AlR3 species to enones; sequential carboalumination-ACA cascades are possible.
Alexakis
Alexandre
A
Department of Organic Chemistry, University of Geneva, Geneva, Switzerland. alexandre.alexakis@chiorg.unige.ch
Albrow
Victoria
V
Biswas
Kallolmay
K
d'Augustin
Magali
M
Prieto
Oscar
O
Woodward
Simon
S