[Expression of laminin and laminin receptor in gestational trophoblastic tumor and its significance].
OBJECTIVE
This study was conducted to detect the expression of laminin (LN) and laminin receptor (LN-R) in the specimens of hydatidiform mole (HM), invasive mole (IM) and choriocarcinoma(CC), respectively.


METHODS
The immunohistological staining method was used.


RESULTS
It was found that the level of the laminin expression was higher in the specimens of choriocarcinoma at more advanced stage.


CONCLUSIONS
The results suggest that there may be relations between the invasion and metastasis of choriocacinoma cell and the malignant degree of this disease, chemotherapy has some effect on the expression of LN and LN-R in gestational trophablastic tumor (GTT), and that LN and LN-R may be of potential value in GTT treatment. However, referring whether LN and LN-R could be used as clinical prognosticators, further studies will be needed.
An
Rui-fang
RF
Department of Obstetric and Gynecology, The First Hospital, Xi'an Jiao Tong Univeristy, China.
Wang
Shu
S
Zhang
Yong-ai
YA
Bai
Xiao-qin
XQ
D000328:Adult; D002822:Choriocarcinoma / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000378:metabolism / Q000473:pathology; D002820:Hydatidiform Mole, Invasive / Q000378:metabolism / Q000473:pathology; D007797:Laminin / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011247:Pregnancy; D017474:Receptors, Laminin / Q000096:biosynthesis* / Q000235:genetics; D014328:Trophoblastic Neoplasms / Q000378:metabolism* / Q000473:pathology; D014594:Uterine Neoplasms / Q000378:metabolism* / Q000473:pathology
D007797:Laminin; D017474:Receptors, Laminin