title: Short and novel stereospecific synthesis of trisubstituted 2,5-diketopiperazines.
abstract: Novel syntheses of chiral trisubstituted 2,5-diketopiperazines using multicomponent Ugi reactions were developed.
authors.affiliation: Department of Medicinal Chemistry, Cardiovascular and Urogenital CEDD, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts SG1 2NY, United Kingdom. Steve.L.Sollis@gsk.com
authors.forename: Steven L
authors.initials: SL
authors.lastname: Sollis
mesh_terms: D020650:Combinatorial Chemistry Techniques; D054659:Diketopiperazines; D015394:Molecular Structure; D010879:Piperazines / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D054659:Diketopiperazines; D010879:Piperazines