title: Does linezolid cause lactic acidosis by inhibiting mitochondrial protein synthesis?
abstract: Linezolid, an oxazolidinone antibiotic, inhibits bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA). We studied 3 patients who experienced lactic acidosis while receiving linezolid therapy. The toxicity may have been caused by linezolid binding to mitochondrial 16S rRNA. Genetic polymorphisms may have contributed to the toxicity in 2 patients.
authors.affiliation: Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA.
authors.forename: Lluis
authors.initials: L
authors.lastname: Palenzuela
authors.forename: Noah M
authors.initials: NM
authors.lastname: Hahn
authors.forename: Robert P
authors.initials: RP
authors.lastname: Nelson
authors.forename: Janet N
authors.initials: JN
authors.lastname: Arno
authors.forename: Carol
authors.initials: C
authors.lastname: Schobert
authors.forename: Robert
authors.initials: R
authors.lastname: Bethel
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Ostrowski
authors.forename: Manjuli R
authors.initials: MR
authors.lastname: Sharma
authors.forename: Partha P
authors.initials: PP
authors.lastname: Datta
authors.forename: Rajendra K
authors.initials: RK
authors.lastname: Agrawal
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Schwartz
authors.forename: Michio
authors.initials: M
authors.lastname: Hirano
mesh_terms: D000081:Acetamides / Q000009:adverse effects*; D000140:Acidosis, Lactic / Q000235:genetics / Q000378:metabolism*; D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D000069349:Linezolid; D008875:Middle Aged; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D023303:Oxazolidinones / Q000009:adverse effects*; D011110:Polymorphism, Genetic; D014176:Protein Biosynthesis / Q000187:drug effects*
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid