Structure and immunological activity of disubstituted thiosemicarbazide isoxazole derivative.
As a part of the research program on isoxazole compounds of immunological activity, we synthesized a new derivative possessing thiosemicarbazide group between 5-amino-3-methylisoxazole-4-carbonyl and phenyl substituent. In the present study, we examined the effect of compound RM2 on the spontaneous proliferative response of splenocytes and mitogen-induced splenocyte proliferation. Synthesis and biological effect is reported.
Maczyński
Marcin
M
Wrocław Medical University, Faculty of Pharmacy, Department of Organic Chemistry, 9 Grodzka Str., 50-137 Wrocław, Poland. marcinm@bf.uni.wroc.pl
Zimecki
Michał
M
Ryng
Stanisław
S
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D049109:Cell Proliferation; D004305:Dose-Response Relationship, Drug; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008808:Mice, Inbred CBA; D012663:Semicarbazides / Q000138:chemical synthesis* / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D013329:Structure-Activity Relationship
D000276:Adjuvants, Immunologic; D007555:Isoxazoles; D012663:Semicarbazides