title: Effect of vitamin E-bonded dialyzer on eosinophilia in haemodialysis patients.
abstract: BACKGROUND
  Eosinophilia in haemodialysis patients probably results from allergy to haemodialysis-related materials, including dialyzer membranes. We examined the effects of vitamin E-bonded dialyzers on eosinophil counts in haemodialysis patients.
  
  
  METHODS
  We enrolled seven patients who were on regular haemodialysis and had sustained eosinophilia. White blood cell, eosinophil, CD4- and CD8-positive lymphocyte counts, and serum interleukin-5 (IL-5) and IgE levels were determined before, 2 and 4 weeks after switching to vitamin E-bonded dialyzers.
  
  
  RESULTS
  Eosinophil and CD4-positive lymphocyte counts and serum IL-5 were significantly (P = 0.003, 0.003 and 0.031, respectively) decreased after switching to vitamin E-bonded dialyzers. CD8-positive lymphocyte counts and serum IgE levels were unaltered. Crossover tests in two cases reproduced the higher eosinophilia within 4 weeks after returning to the original non-vitamin E-bonded dialyzer.
  
  
  CONCLUSIONS
  Vitamin E-bonded dialyzers may ameliorate eosinophilia through a mechanism mediated by a decrease in IL-5 secretion by CD4-positive lymphocytes.
authors.affiliation: Department of Internal Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan. kojima@med.teikyo-u.ac.jp
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Kojima
authors.forename: Kuniyoshi
authors.initials: K
authors.lastname: Oda
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Homma
authors.forename: Kazushi
authors.initials: K
authors.lastname: Takahashi
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Kanda
authors.forename: Taketoshi
authors.initials: T
authors.lastname: Inokami
authors.forename: Shunya
authors.initials: S
authors.lastname: Uchida
mesh_terms: D000704:Analysis of Variance; D015703:Antigens, CD / Q000097:blood; D018592:Cross-Over Studies; D015314:Dialysis Solutions; D004802:Eosinophilia / Q000209:etiology / Q000517:prevention & control*; D004804:Eosinophils; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D015848:Interleukin-5 / Q000097:blood; D007674:Kidney Diseases / Q000097:blood / Q000145:classification / Q000628:therapy; D007958:Leukocyte Count; D018655:Lymphocyte Count; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects / Q000379:methods*; D014807:Vitamin D / Q000494:pharmacology*
chemical_list: D015703:Antigens, CD; D015314:Dialysis Solutions; D015848:Interleukin-5; D014807:Vitamin D; D007073:Immunoglobulin E