title: Biomechanical comparison of human bone-patellar tendon-bone grafts after sterilization with peracetic acid ethanol.
abstract: Recent reports of disease transmission following ACL reconstruction with fresh-frozen non-sterilized allografts have highlighted the need for new sterilization techniques that do not impair the mechanical properties as it was shown for most of the current sterilization techniques. In this in-vitro biomechanical study, it was investigated if peracetic acid ethanol sterilization (PES) has any adverse effects on the mechanical properties of human bone-patellar tendon-bone grafts (BPTB). Paired human BPTB grafts either underwent PES or were used as fresh-frozen non-sterilized grafts. Viscoelastic properties (strain, creep) were analyzed during cyclic submaximal loading and mechanical properties were investigated during load-to-failure (LTF) testing. It was found that there were no differences in viscoelastic and mechanical properties between both groups. The findings of this study provide baseline data for future in vitro and in vivo analyses of this promising new sterilization technique for soft-tissue allografts.
authors.affiliation: Sports Traumatology and Arthroscopy Service, Center for Musculoskeletal Surgery, University Hospital Charité, Berlin, Germany. sven.scheffler@charite.de
authors.forename: S U
authors.initials: SU
authors.lastname: Scheffler
authors.forename: J
authors.initials: J
authors.lastname: Scherler
authors.forename: A
authors.initials: A
authors.lastname: Pruss
authors.forename: R
authors.initials: R
authors.lastname: von Versen
authors.forename: A
authors.initials: A
authors.lastname: Weiler
mesh_terms: D001696:Biomechanical Phenomena; D001842:Bone and Bones; D000431:Ethanol / Q000737:chemistry*; D006801:Humans; D010329:Patella; D010463:Peracetic Acid / Q000737:chemistry*; D013242:Sterilization; D013710:Tendons; D016378:Tissue Transplantation
chemical_list: D000431:Ethanol; D010463:Peracetic Acid