title: [Embryonic sources of definitive hemopoietic stem cells].
abstract: A review of one of the key problems of experimental hematology: the origin of hemopoietic stem cells in the development of vertebrates (amphibians, birds, and mammals). The appearance and functioning of two independent sources of hemopoietic stem cells (extra- and intraembryonic) were considered in amphibians, birds, and mammals. The contribution of each source to the formation of definitive hemopoietic tissue was analyzed. It was shown for amphibians and birds that intraembryonic organs such as the dorsolateral plate and the mesenchyme of dorsal aorta are involved in the formation of adult hemopoietic tissue, while the extraembryonic organs such as ventral islets and the yolk sac are devoid of true stem cells and provide only for the primary, transient hemopoiesis. New data have been considered concerning the previously unknown intraembryonic hemopoietic organ in mammals, a region of aorta-gonad-mesonephros arising in embryogenesis simultaneously with the yolk sac. Two extreme views on the involvement of stem cells of all these organs in the formation of definitive hemopoiesis have been considered. The data are provided on the interaction of the embryonic hemopoietic stem cells and the hemopoietic microenvironment of adult recipients.
authors.forename: E I
authors.initials: EI
authors.lastname: Domaratskaia
authors.forename: V I
authors.initials: VI
authors.lastname: Starostin
authors.forename: N N
authors.initials: NN
authors.lastname: Butorina
mesh_terms: D000663:Amphibians / Q000196:embryology; D000818:Animals; D001717:Birds / Q000196:embryology; D004622:Embryo, Mammalian / Q000166:cytology*; D004625:Embryo, Nonmammalian; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D008322:Mammals / Q000196:embryology