[Early impairment of renal function in chronic heart failure and its clinical significance].
OBJECTIVE
To observe the changes of the microproteinuria (MA) and the relationship in patients with chronic heart failure (CHF).


METHODS
Routine urine protein, blood creatinine and urea nitrogen and MA, immunoglobulin G (UIgG), retinal-binding protein (URbp) and beta-2-microglobulin (Ubeta(2)-MG) were measured and analyzed in 25 patients with CHF, 22 patients with cardiovascular diseases but compensated heart function s and 20 normal volunteers.


RESULTS
The levels of Ualb and UIgG in the CHF group were significantly higher than those in the normal group and compensated heart function group [(7.49 +/- 10.47) mg/mmolCr vs (1.19 +/- 0.85) mg/mmolCr and (1.63 +/- 1.62) mg/mmolCr; (0.82 +/- 1.47) mg/mmolCr vs (0.27 +/- 0.15) mg/mmolCr and (0.40 +/- 0.49) mg/mmolCr; P < 0.01; P < 0.05; respectively] and they were negatively correlated with left ventricular ejection fraction (r = -0.31, r = -0.40, P < 0.01). There were no significant difference of URbp and Ubeta(2)-MG among the above three groups.


CONCLUSIONS
There is early abnormality of renal function in CHF patients without primary renal disorder and the abnormality was featured by impaired glomerular filtration function. The more severe the heart failure, the more significant the renal function impairment.
Jin
Zheng-ming
ZM
Department of Cardiology, the First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310003, China. Jzm57@163.com
Hu
Xiao-sheng
XS
Chen
Jun-zhu
JZ
Hu
Shen-jiang
SJ
Zhang
Fu-rong
FR
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D005260:Female; D005919:Glomerular Filtration Rate; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000503:physiopathology*; D051437:Renal Insufficiency / Q000503:physiopathology*