title: Evaluation of advanced glycation end products and carbonyl compounds in patients with different conditions of oxidative stress.
abstract: Advanced glycation end products (AGE) and dicarbonyl compounds accumulate in serum and tissues of patients with diabetes and chronic renal failure. Pentosidine, free pentosidine, glyoxal and methylglyoxal have been evaluated in plasma of diabetic patients with poor metabolic control at baseline and after the improvement of glycemic levels, and in plasma and peritoneal dialysate of patients with renal failure before and after 12 h of peritoneal dialysis. In diabetic patients, acceptable metabolic control was unable to normalize levels of pentosidine (after 2 and 10 months), glyoxal and methylglyoxal (after 2 months). In patients with end-stage renal disease, mean values of pentosidine, free pentosidine, glyoxal and methylglyoxal decreased in plasma after dialysis. No pentosidine or free pentosidine were present in the peritoneal dialysate at time 0, but were found after 12 h of peritoneal dialysis; glyoxal and methylglyoxal decreased after 12 h of dialysis. So, glyoxal and methylglyoxal, already present in the dialysis fluid, can react with the peritoneal matrix protein, giving a reason for the gradual loss of peritoneal membrane function often observed in patients undergoing long-term peritoneal dialysis.
authors.affiliation: Dipartimento di Scienze Mediche e Chirurgiche - Cattedra di Malattie del Metabolismo, Università di Padova, Padova, Italy. annunziata.lapolla@unipd.it
authors.forename: Annunziata
authors.initials: A
authors.lastname: Lapolla
authors.forename: Rachele
authors.initials: R
authors.lastname: Reitano
authors.forename: Roberta
authors.initials: R
authors.lastname: Seraglia
authors.forename: Giovanni
authors.initials: G
authors.lastname: Sartore
authors.forename: Eugenio
authors.initials: E
authors.lastname: Ragazzi
authors.forename: Pietro
authors.initials: P
authors.lastname: Traldi
mesh_terms: D000368:Aged; D001120:Arginine / Q000031:analogs & derivatives / Q000032:analysis / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D015314:Dialysis Solutions / Q000032:analysis; D006442:Glycated Hemoglobin / Q000032:analysis; D017127:Glycation End Products, Advanced / Q000032:analysis / Q000097:blood*; D006037:Glyoxal / Q000032:analysis / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000378:metabolism; D008239:Lysine / Q000031:analogs & derivatives / Q000032:analysis / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D010530:Peritoneal Dialysis; D011765:Pyruvaldehyde / Q000032:analysis / Q000097:blood
chemical_list: D001120:Arginine; D001786:Blood Glucose; D015314:Dialysis Solutions; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D006037:Glyoxal; D008239:Lysine; D011765:Pyruvaldehyde; C062187:pentosidine