title: New cytotoxic isoflavone from the root bark of Brosimum utile.
abstract: A new isoflavone 5,7,4'-trihydroxy-3'-(3-hydroxy-3-methylbutyl)isoflavone (isowigtheone hydrate) (1), together with six known isoflavones 2-7 and (-)epicatechin, were isolated from the root barks of Brosimum utile. Their structures were established on the basis of spectroscopic evidence. The in vitro cytotoxic activity of the new compound 1 was evaluated against cell lines MCF7 (human breast carcinoma), PC3 (human prostate carcinoma), HT29 (human colon cancer) and human dermis fibroblasts.
authors.affiliation: Istituto di Chimica del Riconoscimento Molecolare CNR, Università Cattolica del Sacro Cuore, Largo F. Vito 1, Rome, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Ferrari
authors.forename: Franco
authors.initials: F
authors.lastname: Delle Monache
authors.forename: Alírica I
authors.initials: AI
authors.lastname: Suárez
authors.forename: Francisco
authors.initials: F
authors.lastname: Arvelo
authors.forename: Reinaldo S
authors.initials: RS
authors.lastname: Compagnone
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007529:Isoflavones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D029586:Moraceae / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*
chemical_list: C503379:5,7,4'-trihydroxy-3'-(3-hydroxy-3-methylbutyl)isoflavone; D000972:Antineoplastic Agents, Phytogenic; D007529:Isoflavones