title: Complete genome sequence of simian adenovirus 1: an Old World monkey adenovirus with two fiber genes.
abstract: Simian adenovirus 1 (SAdV-1) is one of many adenovirus strains that were isolated from Old World monkey cells during poliomyelitis vaccine production several decades ago. Despite the availability of these viruses, knowledge of their genetic content and phylogeny is rudimentary. In the present study, the genome sequence of SAdV-1 (34,450 bp) was determined and analysed. In regions where genetic content varies between primate adenoviruses, SAdV-1 has a single virus-associated RNA gene, six genes in each of the E3 and E4 regions and two fiber genes. SAdV-1 clusters phylogenetically with HAdV-40, a member of human adenovirus species HAdV-F, which also has two fiber genes. However, based on phylogenetic distances and other taxonomic criteria, SAdV-1 is proposed to represent a novel adenovirus species.
authors.affiliation: Veterinary Medical Research Institute, Hungarian Academy of Sciences, PO Box 18, H-1581 Budapest, Hungary.
authors.forename: Gábor M
authors.initials: GM
authors.lastname: Kovács
authors.affiliation: Veterinary Medical Research Institute, Hungarian Academy of Sciences, PO Box 18, H-1581 Budapest, Hungary.
authors.forename: Balázs
authors.initials: B
authors.lastname: Harrach
authors.affiliation: Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E3.
authors.forename: Alexander N
authors.initials: AN
authors.lastname: Zakhartchouk
authors.affiliation: MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Davison
mesh_terms: D000261:Adenoviruses, Simian / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D000956:Antigens, Viral / Q000235:genetics*; D036022:Capsid Proteins / Q000235:genetics*; D002520:Cercopithecidae / Q000821:virology*; D016679:Genome, Viral; D008969:Molecular Sequence Data; D010802:Phylogeny; D016415:Sequence Alignment; D013045:Species Specificity
chemical_list: D000956:Antigens, Viral; D036022:Capsid Proteins; C018315:hexon capsid protein, Adenovirus