[Hepatoprotectors prevent the toxic action of cyclophosphamide on the liver of rats with CCl4-induced hepatitis model].
The results of experiments on white rats with CCl4-induced hepatitis showed that the combined introduction of cyclophosphamide and hepatoprotectors of the plant origin (lochein, maksar, silimarin) leads to a decrease in acute toxicity and to less pronounced manifestations of hepatotoxicity of cyclophosphamide. Hepatoprotectors decrease the activity of aminotransferases, reduce the level of bilirubin, normalize the content of protein andpipids in the blood serum, and suppress the development of morphological disorders in the liver.
Rat'kin
A V
AV
Saratikov
A S
AS
Chuchalin
V S
VS
Burkova
V N
VN
Frolov
V N
VN
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000503:physiopathology; D003520:Cyclophosphamide / Q000633:toxicity*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats
D010936:Plant Extracts; D003520:Cyclophosphamide; D002251:Carbon Tetrachloride