Dysfunction of retinal neurons and glia during diabetes.
Diabetic retinopathy is the leading cause of blindness in those of working age. It is well known that the retinal vasculature is altered during diabetes. More recently, it has emerged that neuronal and glial dysfunction occurs in those with diabetes. Current research is directed at understanding these neuronal and glial changes because they may be an early manifestation of disease processes that ultimately lead to vascular abnormality. This review will highlight the recent advances in our understanding of the neuronal and glial changes that occur during diabetes.
Fletcher
Erica L
EL
Department of Anatomy and Cell Biology, The University of Melbourne, Grattan Street, Parkville, VIC 3010, Australia.
Phipps
Joanna A
JA
Wilkinson-Berka
Jennifer L
JL
D000818:Animals; D003930:Diabetic Retinopathy / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D009457:Neuroglia; D009474:Neurons; D012160:Retina / Q000503:physiopathology*