title: [Study on the relations between serum insulin-like growth factor-1, insulin-like growth factor binding protein-3 and colorectal cancer: a meta-analysis].
abstract: OBJECTIVE
  To evaluate the relationship between circulating levels of insulin-like growth factor-1 (IGF-1), IGF-binding protein-3 (IGFBP-3) and colorectal cancer.
  
  
  METHODS
  A meta-analysis of 6 epidemiological studies on insulin-like growth factors and risk of colorectal cancer were performed.
  
  
  RESULTS
  The pooled odds ratio (OR) of IGF-1 and IGFBP-3 were 1.56 (95% CI: 1.14-2.13) and 0.78 (95% CI: 0.43-1.44) respectively. According to the results from different measurements (enzyme-linked immunoabsorbent assay and immunoradiometric assay), the pooled OR were 1.92 and 1.23 for IGF-1, 0.46 and 1.44 for IGFBP-3 respectively.
  
  
  CONCLUSIONS
  High serum levels of IGF-1 were independent risk factors of colorectal cancer but the OR of IGFBP-3 was not statistically significant. The heterogeneity between studies on IGFBP-3 and colorectal cancer was caused by different measurements used, but there was still a need to conduct simultaneous large size study under 2 different measurements for further conclusion.
authors.affiliation: The Department of Epidemiology, Tongji Medical College, Huazhong University of Science and Thenology, Wuhan 430030, China.
authors.forename: Qiong-hong
authors.initials: QH
authors.lastname: Duan
authors.forename: Zhi-gang
authors.initials: ZG
authors.lastname: Wang
authors.forename: Gui-bao
authors.initials: GB
authors.lastname: Zhu
authors.forename: Zu-xun
authors.initials: ZX
authors.lastname: Lu
authors.forename: Lv-yuan
authors.initials: LY
authors.lastname: Shi
authors.forename: Shao-fa
authors.initials: SF
authors.lastname: Nie
mesh_terms: D002681:China / Q000453:epidemiology; D015179:Colorectal Neoplasms / Q000097:blood / Q000453:epidemiology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D011863:Radioimmunoassay; D012307:Risk Factors
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I