title: Inclusion complexes of azadirachtin with native and methylated cyclodextrins: solubilization and binding ability.
abstract: The inclusion complexation behavior of azadirachtin with several cyclodextrins and their methylated derivatives has been investigated in both solution and the solid state by means of XRD, TG-DTA, DSC, NMR, and UV-vis spectroscopy. The results show that the water solubility of azadirachtin was obviously increased after resulting inclusion complex with cyclodextrins. Typically, beta-cyclodextrin (beta-CD), dimethyl-beta-cyclodextrin (DMbetaCD), permethyl-beta-cyclodextrin (TMbetaCD), and hydroxypropyl-beta-cyclodextrin (HPbetaCD) are found to be able to solubilize azadirachtin to high levels up to 2.7, 1.3, 3.5, and 1.6 mg/mL (calculated as azadirachtin), respectively. This satisfactory water solubility and high thermal stability of the cyclodextrin-azadirachtin complexes, will be potentially useful for their application as herbal medicine or healthcare products.
authors.affiliation: Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, PR China. yuliu@public.tpt.tj.cn
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.forename: Guo-Song
authors.initials: GS
authors.lastname: Chen
authors.forename: Yong
authors.initials: Y
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D004355:Drug Stability; D006358:Hot Temperature; D036701:Limonins / Q000737:chemistry*; D012995:Solubility; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship
chemical_list: D003505:Cyclodextrins; D004337:Drug Carriers; D036701:Limonins; C010329:azadirachtin