Laboratory diagnosis of acute myocardial injury.
Considerable effort by clinicians and scientists focuses on the utility of biomarkers to prevent, diagnose and manage adverse cardiac events as well as provide information on a specific patient's underlying pathology. Although troponins I and T (TnI and TnT) are cardiac specific markers that yield diagnostic and prognostic value in patients with myocardial injury, troponins cannot be utilized in all clinical settings. Troponins have limited utility for the diagnosis of early ischemia and preoperative myocardial infarction. Troponin T also lacks specificity in patients with renal failure. New markers, such as ischemia modified albumin (IMA) and CD40 ligand, and new technologies, such as proteomics, are under investigation to advance our knowledge of heart disease.
Melanson
Stacy Foran
SF
Division of Clinical Laboratories, Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA. semelanson@partners.org
Tanasijevic
Milenko J
MJ
D000418:Albumins / Q000032:analysis; D015415:Biomarkers / Q000097:blood*; D023201:CD40 Ligand / Q000097:blood; D002624:Chemistry, Clinical / Q000379:methods*; D006801:Humans; D007511:Ischemia / Q000097:blood / Q000175:diagnosis; D007755:Laboratories, Hospital; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis*; D019210:Troponin I / Q000097:blood; D020107:Troponin T / Q000097:blood
D000418:Albumins; D015415:Biomarkers; D019210:Troponin I; D020107:Troponin T; D023201:CD40 Ligand