An unusual quinolinone alkaloid from Waltheria douradinha.
The chemical investigation of the methanolic extract of the root bark of Waltheria douradinha (Sterculiaceae) afforded an unusual quinolinone alkaloid named waltherione-A (1). Its structure was determined mainly by NMR spectroscopic methods. The antibacterial activity of waltherione-A (1) and the corresponding O-methylated derivative (2) was tested against three gram-negative and three gram-positive bacteria, with only (2) having moderate activity.
Hoelzel
Solange C S M
SC
Departamento de Química (NPPN), Universidade Federal de Santa Maria, CEP: 97105-900 Santa Maria, RS, Brazil.
Vieira
Eleno R
ER
Giacomelli
Sandro R
SR
Dalcol
Ionara I
II
Zanatta
Nilo
N
Morel
Ademir F
AF
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D019660:Malvaceae / Q000737:chemistry*; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D011804:Quinolines / Q000737:chemistry* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; C502882:O-methylwaltherione A; D011804:Quinolines; C502881:waltherione-A