title: Alkaloids of Aconitum laeve and their anti-inflammatory antioxidant and tyrosinase inhibition activities.
abstract: A lycoctonine-type norditerpenoid alkaloid, swatinine (1), along with four known norditerpenoid alkaloids, delphatine (3), lappaconitine (4), puberanine (5), and N-acetylsepaconitine (6), and were isolated from the aerial parts of Aconitum laeve Royle. Compound 2 has been isolated for the first time from a natural source. The structure of compound 1 was deduced on the basis of spectral data. The anti-inflammatory, antioxidant and tyrosinase inhibition studies on all six compounds have also been carried out.
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Pakistan. farzanailyas@yahoo.com
authors.forename: Farzana
authors.initials: F
authors.lastname: Shaheen
authors.forename: Manzoor
authors.initials: M
authors.lastname: Ahmad
authors.forename: Muhmud Tareq Hassan
authors.initials: MT
authors.lastname: Khan
authors.forename: Saima
authors.initials: S
authors.lastname: Jalil
authors.forename: Asma
authors.initials: A
authors.lastname: Ejaz
authors.forename: Mukhlis N
authors.initials: MN
authors.lastname: Sultankhodjaev
authors.forename: Muhammad
authors.initials: M
authors.lastname: Arfan
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.lastname: Atta-ur-Rahman
mesh_terms: D031841:Aconitum / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D005609:Free Radicals; D006801:Humans; D066298:In Vitro Techniques; D008958:Models, Molecular; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D035261:Plant Components, Aerial / Q000737:chemistry
chemical_list: D000470:Alkaloids; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D005609:Free Radicals; D014442:Monophenol Monooxygenase