AC biosusceptometry in the study of drug delivery.
Conventionally, pharmaceutical substances are administered orally because the gastrointestinal tract possesses the appropriate features for drug absorption. Nevertheless, the gastrointestinal tract physiology is complex and influenced by many factors. These factors must be completely understood for the optimization of oral drug delivery systems. Although in vitro tests provide information about release and drug absorption profiles, in vivo studies are essential, due to the biological variability. Several techniques have been employed in an attempt to conveniently characterize the behavior of solid dosage forms in vivo. The noninvasive biomagnetic technique of alternate current biosusceptometry (ACB) has been used in studies focusing on gastrointestinal motility and, more recently, to evaluate the performance of magnetic dosage forms. This article will discuss the main characteristics of AC biosusceptometry and its applicability for determination of the relationship between the human gastrointestinal tract and orally administered pharmaceutical dosage forms.
Corá
L A
LA
Departamento de Física e Biofísica, Instituto de Biociências, Botucatu-SP, Laboratório de Biomagnetismo, Universidade Estadual Paulista, UNESP, CXP 510, CEP 18618-000, Botucatu, São Paulo, Brazil.
Romeiro
F G
FG
Stelzer
M
M
Américo
M F
MF
Oliveira
R B
RB
Baffa
O
O
Miranda
J R A
JR
D016503:Drug Delivery Systems / Q000379:methods*; D041981:Gastrointestinal Tract / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption; D008280:Magnetics / Q000295:instrumentation*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D013607:Tablets / Q000008:administration & dosage / Q000493:pharmacokinetics; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods
D004364:Pharmaceutical Preparations; D013607:Tablets