A study on the micelle-sensitized Ce(IV)-Na2S2O3-norfloxacin chemiluminescence system and its applications.
A new chemiluminescence (CL) flow-injection method was developed for the determination of norfloxacin. The method is based on the CL reaction of norfloxacin with sodium thiosulphate and Ce(IV) in sulphuric acid medium sensitized by sodium dodecylsulphate. Under optimum conditions, the CL intensity is proportional to the concentration of the norfloxacin in the range 3.89 x 10(-8)-7.18 x 10(-6) g/mL. The detection limit (3 s/k) was 2.21 x 10(-9) g/mL for norfloxacin. The method has been applied successfully to the determination of norfloxacin in pharmaceutical formulations and human urine. The mechanism for this chemiluminescence system is discussed.
Xie
Zenghong
Z
Department of Chemistry, Fuzhou University, Fuzhou 350002, People's Republic of China.
Liao
Sulan
S
Chen
Guonan
G
D002563:Cerium / Q000737:chemistry; D006801:Humans; D008163:Luminescent Measurements / Q000379:methods* / Q000592:standards; D008823:Micelles; D009643:Norfloxacin / Q000032:analysis* / Q000592:standards / Q000652:urine; D004364:Pharmaceutical Preparations / Q000032:analysis; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry; D013885:Thiosulfates / Q000737:chemistry
D008823:Micelles; D004364:Pharmaceutical Preparations; D013885:Thiosulfates; D002563:Cerium; D012967:Sodium Dodecyl Sulfate; C017717:sodium thiosulfate; D009643:Norfloxacin