Ophiocerins A-D and ophioceric acid: tetrahydropyran derivatives and an africane sesquiterpenoid from the freshwater aquatic fungus Ophioceras venezuelense.
Four new tetrahydropyran derivatives called ophiocerins A-D (1-4) and a new africane sesquiterpenoid (ophioceric acid; 5) have been isolated from cultures of the aquatic fungus Ophioceras venezuelense, together with the known compound regiolone. The structures and relative stereochemistry of these compounds were determined by analysis of 1D and 2D NMR data, while absolute stereochemical assignments for 1-4 were proposed by application of the exciton chirality CD method.
Reátegui
Ricardo F
RF
Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
Gloer
James B
JB
Campbell
Jinx
J
Shearer
Carol A
CA
D002942:Circular Dichroism; D003364:Costa Rica; D005618:Fresh Water; D020082:Magnaporthe / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
D011714:Pyrans; D012717:Sesquiterpenes; C501713:ophioceric acid