title: Multicentre EORTC study 16997: feasibility and phase II trial of farnesyl transferase inhibitor & gemcitabine combination in salvage treatment of advanced urothelial tract cancers.
abstract: In this study, the feasibility and activity of combined chemotherapy of the farnesyl transferase inhibitor SCH66336 and gemcitabine was evaluated. This therapy was used as second-line treatment in patients with advanced urothelial tract cancer and the influence of SCH66336 exposure on the pharmacokinetics of gemcitabine was also determined. Patients who had received one previous chemotherapy regime for advanced urothelial cancer were treated with a combination of SCH66336 (150 mg in the morning and 100 mg in the evening) and Gemcitabine (1000 mg/m2 on day 1, 8 and 15 per 28-day cycle). Dosages of gemcitabine and its metabolite dFdU were performed on day one of cycle 1 before exposure to SCH66336 and day one of cycle 2. A total of 152 cycles were administered in 33 patients (median 3, range: 1-15). No patients had severe hematological toxicity, defined as Grade 4 thrombocytopenia or febrile neutropenia. Nine partial responses and one complete response were achieved in 31 assessable patients and corresponded to an overall response rate of 32.3% [95% CI:17%-51%]. There was no influence of exposure to SCH66336 on the level of gemcitabine or dFdU in 11 assessable patients. In conclusion, a combination of SCH66336 and gemcitabine is feasible in terms of toxicity and active as second-line treatment in patients with advanced urothelial tract cancer. SCH66336 had no effect on the pharmacokinetics of gemcitabine. Randomised trials should be undertaken to clarify the role of SCH66336 in combination with gemcitabine in cancer treatment.
authors.affiliation: Institut Gustave Roussy, Department of Medicine, 39, rue Camille Desmoulins 94805, Villejuif, France. theodore@igr.fr
authors.forename: C
authors.initials: C
authors.lastname: Theodore
authors.forename: L
authors.initials: L
authors.lastname: Geoffrois
authors.forename: J B
authors.initials: JB
authors.lastname: Vermorken
authors.forename: F
authors.initials: F
authors.lastname: Caponigro
authors.forename: W
authors.initials: W
authors.lastname: Fiedler
authors.forename: P
authors.initials: P
authors.lastname: Chollet
authors.forename: A
authors.initials: A
authors.lastname: Ravaud
authors.forename: G J
authors.initials: GJ
authors.lastname: Peters
authors.forename: C
authors.initials: C
authors.lastname: de Balincourt
authors.forename: D
authors.initials: D
authors.lastname: Lacombe
authors.forename: P
authors.initials: P
authors.lastname: Fumoleau
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D018450:Disease Progression; D051231:Farnesyltranstransferase; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D011725:Pyridines / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D016879:Salvage Therapy; D016019:Survival Analysis; D014571:Urologic Neoplasms / Q000188:drug therapy*; D000093542:Gemcitabine; D003986:Dibenzocycloheptenes
chemical_list: D019883:Alkyl and Aryl Transferases; D003841:Deoxycytidine; D051231:Farnesyltranstransferase; D010880:Piperidines; D011725:Pyridines; D000093542:Gemcitabine; C115354:lonafarnib; D003986:Dibenzocycloheptenes