Concomitant Ewing sarcoma and acute lymphoblastic leukemia in a 5-year-old girl.
Malignancies from the Ewing family of tumors and acute lymphoblastic leukemia (ALL) are not known to be associated with each other. A 5-year-old girl was incidentally found to suffer from acute lymphoblastic leukemia during bone marrow staging for Ewing sarcoma of the radius. The simultaneous presence of two distinct neoplasms was confirmed by RT-PCR, with EWS/FLI1 type 1 rearrangement in the bone tumor and TEL/AML1 rearrangement in the marrow. She was treated with chemotherapy, radiotherapy, and surgery and was in remission of both diseases 31 months after diagnosis.
Masjosthusmann
Katja
K
Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany.
Bielack
Stefan S
SS
Köhler
Gabriele
G
Florax
Annekathrein
A
Schiborr
Manfred
M
Bruch
Jochen
J
Reinhardt
Dirk
D
Kuhn
Nanna
N
Paulussen
Michael
M
Jürgens
Herbert
H
D002675:Child, Preschool; D003131:Combined Modality Therapy; D050676:Core Binding Factor Alpha 2 Subunit; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015514:Oncogene Proteins, Fusion; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D051789:Proto-Oncogene Protein c-fli-1; D034802:RNA-Binding Protein EWS; D012512:Sarcoma, Ewing / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D014178:Translocation, Genetic; D000097764:ETS Translocation Variant 6 Protein
D050676:Core Binding Factor Alpha 2 Subunit; D015514:Oncogene Proteins, Fusion; D051789:Proto-Oncogene Protein c-fli-1; D034802:RNA-Binding Protein EWS; C106031:EWS-FLI fusion protein; C102421:TEL-AML1 fusion protein; D000097764:ETS Translocation Variant 6 Protein