Do healthy potential kidney donors in india have an average glomerular filtration rate of 81.4 ml/min?
BACKGROUND
Until now, a normal reference range for glomerular filtration rate (GFR) in adult Indian potential kidney donors has not been determined and values from a western population are being used as reference.


OBJECTIVE
To determine the reference range of GFR in healthy adult Indian potential kidney donors.


METHODS
GFR was measured in 610 (250 male, 360 female, average age 35.16 years) healthy potential kidney donors using the 99mTc-DTPA (diethylenetriamine pentaacetic acid) two-plasma sample method of Russell.


RESULTS
The mean body surface area (BSA)-normalized GFR value of a young healthy Indian adult potential kidney donor was calculated as 81.4 +/- 19.4 ml/min/1.73 m2 BSA--for males it was 82.3 +/- 21.3 ml/min/1.73 m2 BSA and for females 80.8 +/- 18.1 ml/min/1.73 m2 BSA. There was no significant difference between derived mean GFR values in males and females with a p value of 0.37.


CONCLUSIONS
The normal GFR value for the healthy Indian adult potential kidney donor appears to be much lower than the accepted value for a western population. The mean GFR value of a young healthy Indian adult potential kidney donor is 81.4 +/- 19.4 ml/min/1.73 m2 BSA, which is significantly different from the normal value of 109-125 ml/min derived from a western population. These findings might be useful in deciding on a suitable kidney donor in an Indian context.
Barai
Sukanta
S
Department of Nuclear Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. danzig@rediffmail.com
Bandopadhayaya
G P
GP
Patel
C D
CD
Rathi
Manish
M
Kumar
R
R
Bhowmik
D
D
Gambhir
S
S
Singh
N Gopendro
NG
Malhotra
A
A
Gupta
K D
KD
D000328:Adult; D017677:Age Distribution; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007194:India / Q000453:epidemiology; D007668:Kidney / Q000000981:diagnostic imaging / Q000502:physiology*; D016030:Kidney Transplantation / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012016:Reference Values; D017678:Sex Distribution; D014019:Tissue Donors / Q000706:statistics & numerical data*