Achievement of behavioral efficacy and improved potency in new heterocyclic analogs of benzofuran H3 antagonists.
Cowart
M
M
Department R4MN, AP9A-216, Abbott Laboratories, Global Pharmaceutical Research and Development, 100 Abbott Park Road, Abbott Park, IL 60064-6123, USA. marlon.d.cowart@abbott.com
Faghih
R
R
Gfesser
G
G
Curtis
M
M
Sun
M
M
Zhao
C
C
Bennani
Y
Y
Wetter
J
J
Marsh
K
K
Miller
T R
TR
Krueger
K
K
Pan
J B
JB
Drescher
K
K
Fox
G B
GB
Esbenshade
T A
TA
Hancock
A A
AA
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001572:Benzofurans / Q000737:chemistry* / Q000494:pharmacology*; D003500:Cyclization; D006633:Histamine Antagonists / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D051381:Rats; D018100:Receptors, Histamine H3 / Q000378:metabolism*
D001572:Benzofurans; D006633:Histamine Antagonists; D018100:Receptors, Histamine H3; C105430:benzofuran