Best evidence topic report. Terlipressin or somatostatin for the treatment of bleeding oesophageal varices.
A short cut review was carried out to establish whether terlipressin or somatostatin is more effective at reducing acute bleeding in adults with known oesophageal varices. Altogether 170 papers were found using the reported search, of which four presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results, and study weaknesses of these best papers are tabulated. A clinical bottom line is stated.
Boyd
Russel
R
Butler
John
J
D000208:Acute Disease; D004932:Esophageal and Gastric Varices / Q000150:complications / Q000188:drug therapy*; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D006728:Hormones / Q000627:therapeutic use*; D006801:Humans; D008236:Lypressin / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D013004:Somatostatin / Q000627:therapeutic use*; D000077585:Terlipressin; D016896:Treatment Outcome; D014662:Vasoconstrictor Agents / Q000627:therapeutic use*
D006728:Hormones; D014662:Vasoconstrictor Agents; D008236:Lypressin; D013004:Somatostatin; D000077585:Terlipressin