title: In vitro activity and killing effect of citropin 1.1 against gram-positive pathogens causing skin and soft tissue infections.
abstract: The in vitro activity of citropin 1.1 against gram-positive cocci was measured by MIC, minimal bactericidal concentration, time-kill studies, and a checkerboard titration method. Streptococci and staphylococci were inhibited at concentrations between 1 and 16 mg/liter, respectively. Enterococci showed less susceptibility. Synergy was demonstrated when citropin 1.1 was combined with clarithromycin and doxycycline.
authors.affiliation: Institute of Infectious Diseases and Public Health, c/o Ospedale Regionale, via Conca, 71, Ancona, I-60020, Italy. anconacmi@interfree.it
authors.forename: Andrea
authors.initials: A
authors.lastname: Giacometti
authors.forename: Oscar
authors.initials: O
authors.lastname: Cirioni
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kamysz
authors.forename: Carmela
authors.initials: C
authors.lastname: Silvestri
authors.forename: Maria Simona
authors.initials: MS
authors.lastname: Del Prete
authors.forename: Alberto
authors.initials: A
authors.lastname: Licci
authors.forename: Giuseppina
authors.initials: G
authors.lastname: D'Amato
authors.forename: Jerzy
authors.initials: J
authors.lastname: Łukasiak
authors.forename: Giorgio
authors.initials: G
authors.lastname: Scalise
mesh_terms: D029845:Amphibian Proteins / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D015169:Colony Count, Microbial; D004347:Drug Interactions; D024881:Drug Resistance, Bacterial; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology; D006095:Gram-Positive Cocci / Q000187:drug effects* / Q000254:growth & development*; D006801:Humans; D008826:Microbial Sensitivity Tests; D017192:Skin Diseases, Bacterial / Q000382:microbiology*; D018461:Soft Tissue Infections / Q000382:microbiology*
chemical_list: D029845:Amphibian Proteins; D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; C121829:citropin 1.1 protein, Litoria