title: Conservative surgical approach for thyroid and lymph-node involvement in papillary thyroid carcinoma of childhood and adolescence.
abstract: BACKGROUND
  Prior to 1990s, papillary thyroid carcinomas (PTCs) in childhood/adolescence underwent a standard therapeutic approach (total thyroidectomy plus elective neck dissection, followed by radioactive iodine (RAI) ablation), with an overall survival of about 100%. The aim of this study is to outline the possibility of a conservative approach (hemithyroidectomy plus selective neck dissection of clinically involved nodes, followed by TSH-suppressive therapy) in a selected group of patients.
  
  
  METHODS
  From 1968 to 2001, 42 pediatric PTC patients were treated at our institution. Absence of distant metastases and a tumor clinically limited to one lobe were both present in 28 cases that underwent a radical (20 cases) or a conservative (8 cases) surgical approach at the thyroid level. At cervical node level, 10 patients underwent a radical and 32 a conservative surgical approach. Clinicopathologic features at onset, type of therapy (radical vs. conservative), post-operative complications, and outcome till May 31, 2004 were recorded. The impact of the type of surgery on outcome was evaluated.
  
  
  RESULTS
  Overall and progression-free survival (PFS) curves were found to be independent of the type of therapy (radical vs. conservative) in subgroups of patients matched for extent of disease at onset. Post-operative complications occurred only with radical surgical approaches.
  
  
  CONCLUSIONS
  Childhood and adolescence PTCs show a high rate of spread but an excellent outcome independent of the type of therapy (radical vs. conservative). Taking into account the marked responsiveness to TSH-suppression and the complications after radical therapy, in selected cases, a conservative approach should be considered, reserving more aggressive therapies in case of metastases or relapse.
authors.affiliation: Unit of Pediatrics, Istituto Nazionale Tumori, Milan, Italy. maura.massimino@istitutotumori.mi.it
authors.forename: Maura
authors.initials: M
authors.lastname: Massimino
authors.forename: Paola
authors.initials: P
authors.lastname: Collini
authors.forename: Silvia Fagundes
authors.initials: SF
authors.lastname: Leite
authors.forename: Filippo
authors.initials: F
authors.lastname: Spreafico
authors.forename: Nicola
authors.initials: N
authors.lastname: Zucchini
authors.forename: Andrea
authors.initials: A
authors.lastname: Ferrari
authors.forename: Franco
authors.initials: F
authors.lastname: Mattavelli
authors.forename: Ettore
authors.initials: E
authors.lastname: Seregni
authors.forename: Maria Rita
authors.initials: MR
authors.lastname: Castellani
authors.forename: Giulio
authors.initials: G
authors.lastname: Cantù
authors.forename: Franca
authors.initials: F
authors.lastname: Fossati-Bellani
authors.forename: Juan
authors.initials: J
authors.lastname: Rosai
mesh_terms: D000293:Adolescent; D002291:Carcinoma, Papillary / Q000145:classification / Q000401:mortality / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000145:classification / Q000401:mortality / Q000601:surgery*; D013965:Thyroidectomy / Q000009:adverse effects / Q000379:methods