title: Enantioselective synthesis of 2-aryl-4-piperidones via rhodium/phosphoramidite-catalyzed conjugate addition of arylboroxines.
abstract: [reaction: see text] The highly enantioselective synthesis of 2-aryl-4-piperidones by rhodium/phosphoramidite-catalyzed conjugate addition of arylboroxines to 2,3-dihydro-4-pyridones is described. Both enantiomers of a variety of products with sterically and electronically different R substituents were obtained in high isolated yield and with excellent enantioselectivity up to 99%.
authors.affiliation: Department of Organic and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
authors.forename: Richard B C
authors.initials: RB
authors.lastname: Jagt
authors.forename: Johannes G
authors.initials: JG
authors.lastname: de Vries
authors.forename: Ben L
authors.initials: BL
authors.lastname: Feringa
authors.forename: Adriaan J
authors.initials: AJ
authors.lastname: Minnaard