title: Identification of protogenin, a novel immunoglobulin superfamily gene expressed during early chick embryogenesis.
abstract: We have identified a chick cDNA encoding the novel membrane protein, Protogenin. It has structural features of four immunoglobulin domains and five fibronectin type III domains and is closely related to the DCC/neogenin subclass of the Ig superfamily. protogenin gene is conserved among human, mouse and chick genome, and mapped on the same chromosome as other related members of the gene family such as neogenin, punc and nope. Expression of protogenin mRNA is most prominent in E1-E3 chick embryos and subsequently its expression level declines. The transcripts are found in early mesodermal cells, the neuroepithelial cell layer of the brain and the trunk neural tube, the neural layer of the retina and in the epithelial somite and dermomyotome.
authors.affiliation: Department of Molecular Neurobiology, Graduate School of Life Sciences, Tohoku University, Sendai 980-8575, Japan.
authors.forename: Reiko
authors.initials: R
authors.lastname: Toyoda
authors.forename: Harukazu
authors.initials: H
authors.lastname: Nakamura
authors.forename: Yuji
authors.initials: Y
authors.lastname: Watanabe
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002642:Chick Embryo / Q000196:embryology; D002874:Chromosome Mapping; D018076:DNA, Complementary / Q000235:genetics; D004625:Embryo, Nonmammalian / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D008565:Membrane Proteins / Q000235:genetics*; D008636:Mesencephalon / Q000502:physiology; D008969:Molecular Sequence Data; D009024:Morphogenesis; D010802:Phylogeny; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D018076:DNA, Complementary; D008565:Membrane Proteins; D012333:RNA, Messenger