title: [Histomorphological study of experimentally induced canalolithiasis].
abstract: Free otoconia in the posterior semicircular canal (pSCC) are regarded as the main reason for benign paroxysmal positional vertigo. We investigated the distribution of otoconia in the membranous labyrinth of guinea pigs (n = 34) after a defined rotatory/angular kinetic acceleration. The angular kinetic energy of the rotatory experiment produced a dislocation of the otoconia and sometimes of the complete gelatinous otolithic membrane of the utricular and saccular macula. The otoconia could be observed in all three semicircular canals but predominated in the dark cell areas of the utricular side of the lateral SCC. A total obstruction of the semicircular canal could never be seen. Close to the lateral crista, perilymphatic hemorrhage could frequently be observed. The saccular otoconia were located in the amalgamation between endolymphatic membrane and saccule. The results of this histological study can form the basis for different theories about the genesis of canalolithiasis and cupulolithiasis and the vertigo which accompanies them.
authors.affiliation: Hals-Nasen-Ohrenklinik, Universitätsklinikum Hamburg-Eppendorf. sanchez@uke.uni-hamburg.de
authors.forename: M
authors.initials: M
authors.lastname: Sanchez-Hanke
authors.forename: B
authors.initials: B
authors.lastname: Tolsdorff
authors.forename: R
authors.initials: R
authors.lastname: Leuwer
mesh_terms: D000054:Acceleration / Q000009:adverse effects*; D000818:Animals; D004195:Disease Models, Animal; D006168:Guinea Pigs; D020347:Lithiasis / Q000209:etiology* / Q000473:pathology*; D010812:Physical Stimulation / Q000009:adverse effects* / Q000379:methods; D015837:Vestibular Diseases / Q000209:etiology* / Q000473:pathology*