[The role of stem and pluripotent cells in differentiation and the neoplastic transformation of pancreatic cells].
Certain differentiation-specific antigenic determinants are characteristic of pancreatic cells at each stage of embryonic development. Using immunohistochemical markers, we have demonstrated that the cells of several pancreatic tumors express some fetal proteins characteristic of embryonic cells of the pancreas. We propose that the presence of fetal antigens and proteins in the tumor is a sign of a lower tumor differentiation and a less favorable prognosis.
Gurevich
L E
LE
Kazantseva
I A
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Borodataia
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EV
D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic; D004622:Embryo, Mammalian / Q000166:cytology; D005326:Fetal Proteins / Q000032:analysis*; D006801:Humans; D010179:Pancreas / Q000166:cytology* / Q000196:embryology / Q000276:immunology; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000209:etiology* / Q000276:immunology; D039904:Pluripotent Stem Cells / Q000502:physiology*; D011379:Prognosis; D013234:Stem Cells / Q000502:physiology*
D005326:Fetal Proteins