Antiproliferative activities of iron and platinum conjugates of salicylaldehyde semi-/thiosemicarbazones against C6 glioma cells.
The identification of novel therapeutic agents for the management of malignant gliomas represents an area of active research. Here, we show that among the iron and platinum complexes of 2-hydroxybenzaldehyde semi-/thiosemicarbazones the latter inhibits the growth of C6 glioma cells in vitro with an IC50 value of 45 microM. Structural characterization reveals iron complexes to be octahedral having intermediate S = 3/2 spin states while platinum complexes are found to be square planar moieties. Our findings suggest that the platinum compounds of 2-hydroxybenzaldehyde thiosemicarbazone are potential candidates for the treatment of malignant gliomas.
Patole
J
J
Department of Chemistry, University of Pune, Pune 411007, India.
Padhye
S
S
Moodbidri
M S
MS
Shirsat
N
N
D000447:Aldehydes / Q000737:chemistry*; D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005910:Glioma / Q000473:pathology*; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure; D010984:Platinum / Q000737:chemistry*; D051381:Rats; D013882:Thiosemicarbazones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
D000447:Aldehydes; D013882:Thiosemicarbazones; C013243:salicylaldehyde; D010984:Platinum; D007501:Iron