title: Randomized clinical trial comparing regional and general anaesthesia in minimally invasive video-assisted parathyroidectomy.
abstract: BACKGROUND
  This randomized clinical trial was performed in a single institution to compare the results of minimally invasive video-assisted parathyroidectomy (MIVAP) conducted under regional anaesthesia (RA) or general anaesthesia (GA).
  
  
  METHODS
  Fifty-one patients undergoing MIVAP for primary hyperparathyroidism were assigned randomly to either RA (26 patients) or GA (25). RA involved a bilateral deep cervical block, and local infiltration of the incision site with a mixture of 0.25 per cent lignocaine and 0.15 per cent bupivacaine. GA was induced by intravenous administration of propofol, remifentanil and rocuronium bromide.
  
  
  RESULTS
  The two groups were matched for age, sex, adenoma size, and preoperative serum calcium and parathyroid hormone levels. The interval from skin incision to closure was similar in the two groups (27.6 and 25.8 min for RA and GA respectively), whereas the total operating time (from induction of anaesthesia to return to the ward) was significantly lower with RA (72.1 versus 90.2 min; P = 0.001). The postoperative requirement for pain medication, measured in terms of amount of ketorolac administered at the request of the patient, was significantly lower in the RA group (28.5 versus 80 mg/day; P < 0.001).
  
  
  CONCLUSIONS
  MIVAP performed under RA was associated with a shorter overall operating time and a reduced need for postoperative pain relief.
authors.affiliation: Department of Surgery, Ospedale Santa Chiara, University of Pisa, Italy. p.miccoli@dc.med.unipi.it
authors.forename: P
authors.initials: P
authors.lastname: Miccoli
authors.forename: L
authors.initials: L
authors.lastname: Barellini
authors.forename: J M
authors.initials: JM
authors.lastname: Monchik
authors.forename: R
authors.initials: R
authors.lastname: Rago
authors.forename: P F
authors.initials: PF
authors.lastname: Berti
mesh_terms: D000328:Adult; D000368:Aged; D000765:Anesthesia, Conduction / Q000379:methods*; D000768:Anesthesia, General / Q000379:methods*; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood / Q000601:surgery*; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures / Q000379:methods; D010281:Parathyroid Hormone / Q000097:blood; D016105:Parathyroidectomy / Q000379:methods*; D020535:Video-Assisted Surgery / Q000379:methods*
chemical_list: D010281:Parathyroid Hormone