title: Fundoplication eliminates chronic cough due to non-acid reflux identified by impedance pH monitoring.
abstract: The symptoms of extra-oesophageal gastro-oesophageal reflux disease (GORD) (such as chronic cough and hoarseness) are traditionally more difficult to treat than typical GORD symptoms (heartburn and regurgitation). Patients with extra-oesophageal manifestations may require longer and higher doses of acid suppressive therapy. In patients not responding to acid suppressive therapy the physician faces a dilemma as to whether the symptoms are due to ongoing acid reflux, non-acid reflux, or not associated with reflux. We report the case of a 45 year old woman with a history of a chronic cough referred for fundoplication after documenting her symptoms were associated with non-acid reflux using multichannel intraluminal impedance and pH (MII-pH).
authors.affiliation: Division of Gastroenterology and Hepatology, Medical University South Carolina, 96 Jonathan Lucas Street, 210 Clinical Science Building, P O Box 250327 Charleston, SC 29425, USA. mainie@musc.edu
authors.forename: I
authors.initials: I
authors.lastname: Mainie
authors.forename: R
authors.initials: R
authors.lastname: Tutuian
authors.forename: A
authors.initials: A
authors.lastname: Agrawal
authors.forename: A
authors.initials: A
authors.lastname: Hila
authors.forename: K B
authors.initials: KB
authors.lastname: Highland
authors.forename: D B
authors.initials: DB
authors.lastname: Adams
authors.forename: D O
authors.initials: DO
authors.lastname: Castell
mesh_terms: D002908:Chronic Disease; D003371:Cough / Q000209:etiology / Q000628:therapy*; D017097:Electric Impedance; D005260:Female; D018662:Fundoplication / Q000379:methods*; D005764:Gastroesophageal Reflux / Q000150:complications / Q000628:therapy*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008875:Middle Aged