title: Malignant hypertension secondary to cortisol-secreting adrenal tumour.
abstract: Adrenal cortical tumour-induced malignant hypertension is rare, except for some documented aldosterone-producing adenomas. Hypertension is a common feature of Cushing's syndrome, whereas malignant hypertension is rarely seen. This case in Taiwan is only the second reported case with malignant hypertension secondary to a cortisol-secreting adrenal tumour. The immunohistochemical study of the excised tumour showed strong positive staining of interleukin (IL)-6. IL-6 can trigger inflammatory vascular damage, which is typical in the malignant phase of hypertension. We hypothesise that IL-6 may have played an important role in this case.
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
authors.forename: Shao-Wen
authors.initials: SW
authors.lastname: Weng
authors.forename: Cheng-Hsu
authors.initials: CH
authors.lastname: Yang
authors.forename: Wan-Ting
authors.initials: WT
authors.lastname: Huang
authors.forename: Mien-Cheng
authors.initials: MC
authors.lastname: Chen
authors.forename: Pei-Wen
authors.initials: PW
authors.lastname: Wang
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D000315:Adrenalectomy; D018246:Adrenocortical Adenoma / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism*; D006974:Hypertension, Malignant / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D006854:Hydrocortisone