title: [Preoperative concurrent chemotherapy and radiation therapy in cervix cancer: preliminary results].
abstract: This is a retrospective study of patients treated for cervix cancer staged IB2, IIA or IIB with bulky tumor (> 4cm). Treatment was concurrent radiotherapy (45Gy with 1,8Gy daily fraction) and chemotherapy (5 cycles of Platinum 40mg/m2/week). All patients underwent Brachytherapy (15Gy on the reference isodose according to Paris system) followed by surgery (radical abdominal hysterectomy and bilateral pelvic lymphadenectomy: Piver 3) Between October 1999 and December 2002, forty five patients were treated in this protocol. Median age was 46 years (21- 68). Histology was squamous cell carcinoma in 93% and glandular carcinoma in 7%. Average external radiation dose was 44Gy (20-50). Ninety three percent of patients had at least 3 cycles of chemotherapy and 46,5% received the planned 5 cycles. On the operative specimens, there was 62,5% complete response and only 7 pelvic node involvement (17,5%). Four postoperative complications were noted (one vascular injury, one urinary fistula, one phlebitis and one lymph collection). Preoperative combined radiotherapy and chemotherapy in the early bulky stages of uterine cervix cancer is well tolerated and "gives" a high rate of sterilisation. There was no increase in surgical morbidity.
authors.affiliation: Institut Salah Azaiz, Tunis.
authors.forename: Lotfi
authors.initials: L
authors.lastname: Kochbati
authors.forename: Chiraz Nasr
authors.initials: CN
authors.lastname: Ben Ammar
authors.forename: Farouk
authors.initials: F
authors.lastname: Benna
authors.forename: Monia
authors.initials: M
authors.lastname: Hechiche
authors.forename: Hamouda
authors.initials: H
authors.lastname: Boussen
authors.forename: Mounir
authors.initials: M
authors.lastname: Besbes
authors.forename: Mansour
authors.initials: M
authors.lastname: Ben Abdallah
authors.forename: Khaled
authors.initials: K
authors.lastname: Rahal
authors.forename: Farhat
authors.initials: F
authors.lastname: Ben Ayed
authors.forename: Khaked
authors.initials: K
authors.lastname: Ben Romdhane
authors.forename: Mongi
authors.initials: M
authors.lastname: Maalej
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001918:Brachytherapy; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D002584:Cervix Uteri / Q000473:pathology; D002945:Cisplatin / Q000627:therapeutic use; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008197:Lymph Node Excision; D008875:Middle Aged; D009367:Neoplasm Staging; D011300:Preoperative Care; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents; D003037:Cobalt Radioisotopes; D002945:Cisplatin