Important bacterial gastrointestinal pathogens in children: a pathogenesis perspective.
This article focuses on the five most common bacterial enteropathogens of the developed world--Helicobacter pylori, Escherichia coli, Shigella, Salmonella, and Campylobacter--from the perspective of how they cause disease and how they relate to each other. Basic and recurring themes of bacterial pathogenesis, including mechanisms of entry, methods of adherence, sites of cellular injury, role of toxins, and how pathogens acquire particular virulence traits (and antimicrobial resistance), are discussed.
Amieva
Manuel R
MR
Department of Pediatrics, Division of Infectious Diseases, Stanford University School of Medicine, CA 94305-5208, USA. amieva@stanford.edu
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D002169:Campylobacter Infections / Q000382:microbiology; D002448:Cell Adhesion; D002648:Child; D002669:Child Welfare / Q000706:statistics & numerical data; D019049:Developed Countries; D024881:Drug Resistance, Bacterial; D004405:Dysentery, Bacillary / Q000382:microbiology; D004926:Escherichia coli / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000382:microbiology; D005759:Gastroenteritis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D016481:Helicobacter Infections / Q000382:microbiology; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D008826:Microbial Sensitivity Tests; D010372:Pediatrics / Q000379:methods*; D012480:Salmonella Infections / Q000382:microbiology
D000900:Anti-Bacterial Agents