title: Pseudomonas aeruginosa infection: an uncommon cause of post-renal obstruction following induction therapy for acute lymphoblastic leukemia.
abstract: A 14-month-old infant presented with gastroenteritis with febrile pancytopenia and was diagnosed with acute lymphocytic leukemia (ALL). Ten days post induction therapy, the patient developed hypertension that was ascribed to steroid therapy and treated with metoprolol and amlodipine. As leukocyte numbers began to recover the asymptomatic patient became anuric. Ultrasound showed echoic floating structures in the bladder. Following cystoscopy and retrograde pyelography examination, purulent debris was irrigated from the bladder and grew Pseudomonas aeruginosa. Ciprofloxacin therapy was initiated and renal function was restored within 2 days. The case highlights the potential for renal obstruction after neutropenia recovery in children undergoing induction therapy for ALL.
authors.affiliation: Faculty of Medicine, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada.
authors.forename: Karolina M
authors.initials: KM
authors.lastname: Burghardt
authors.forename: Michael
authors.initials: M
authors.lastname: Leonard
authors.forename: Janusz
authors.initials: J
authors.lastname: Feber
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Halton
authors.forename: Guido
authors.initials: G
authors.lastname: Filler
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001002:Anuria / Q000209:etiology; D002939:Ciprofloxacin / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007223:Infant; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000188:drug therapy*; D011552:Pseudomonas Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification; D016896:Treatment Outcome; D014517:Ureteral Obstruction / Q000150:complications / Q000382:microbiology / Q000601:surgery*; D014552:Urinary Tract Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology
chemical_list: D002939:Ciprofloxacin