Process or perish: quality control in mRNA biogenesis.
Production of mature mRNAs that encode functional proteins consists of a highly complex pathway of synthesis, processing and export. Along this pathway, the mRNA transcript is scrutinized by quality control machinery at numerous steps. Such extensive RNA surveillance ensures that only correctly processed mature mRNAs are translated and precludes production of aberrant transcripts that could encode mutant or possibly deleterious proteins.
Fasken
Milo B
MB
Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Road, NE, Atlanta, Georgia 30322, USA.
Corbett
Anita H
AH
D000818:Animals; D002467:Cell Nucleus / Q000235:genetics / Q000502:physiology; D004175:Diptera; D007313:Insecta; D008322:Mammals; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics*; D014158:Transcription, Genetic
D012333:RNA, Messenger