A simple and efficient copper-catalyzed procedure for the hydrosilylation of hindered and functionalized ketones.
The catalytic hydrosilylation of highly hindered and functionalized ketones is described. The combination of inexpensive catalyst precursors, CuCl and NHC.HX (NHC = N-heterocyclic carbene), leads to a highly efficient reduction mediator for the preparation of silyl ethers from unfunctionalized and functionalized alkyl, cyclic, bicyclic, aromatic, and heteroaromatic ketones. A series of catalyst precursors have been structurally characterized and a catalyst-structure activity relationship is discussed.
Díez-González
Silvia
S
Department of Chemistry, University of New Orleans, New Orleans, Louisiana 70148, USA.
Kaur
Harneet
H
Zinn
Fabiano Kauer
FK
Stevens
Edwin D
ED
Nolan
Steven P
SP