title: Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid.
abstract: A novel series of non-nucleoside HCV NS5B polymerase inhibitors was prepared from a (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid template. Solution and solid phase analog synthesis focused on the northern region of the template combined with structure based design led to the discovery of several potent and orally bioavailable lead compounds.
authors.affiliation: Pfizer Global Research & Development, Michigan Laboratories, Ann Arbor, 48105, USA. jeffrey.a.pfefferkorn@pfizer.com
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Pfefferkorn
authors.forename: Richard
authors.initials: R
authors.lastname: Nugent
authors.forename: Rebecca J
authors.initials: RJ
authors.lastname: Gross
authors.forename: Meredith
authors.initials: M
authors.lastname: Greene
authors.forename: Mark A
authors.initials: MA
authors.lastname: Mitchell
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Reding
authors.forename: Lee A
authors.initials: LA
authors.lastname: Funk
authors.forename: Rebecca
authors.initials: R
authors.lastname: Anderson
authors.forename: Peter A
authors.initials: PA
authors.lastname: Wells
authors.forename: John A
authors.initials: JA
authors.lastname: Shelly
authors.forename: Robert
authors.initials: R
authors.lastname: Anstadt
authors.forename: Barry C
authors.initials: BC
authors.lastname: Finzel
authors.forename: Melissa S
authors.initials: MS
authors.lastname: Harris
authors.forename: Robert E
authors.initials: RE
authors.lastname: Kilkuskie
authors.forename: Laurice A
authors.initials: LA
authors.lastname: Kopta
authors.forename: Francis J
authors.initials: FJ
authors.lastname: Schwende
mesh_terms: D000179:Acrylates / Q000737:chemistry* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors*; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors*
chemical_list: C504932:(2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid; D000179:Acrylates; D004791:Enzyme Inhibitors; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase