[Bone quality in fracture callus].
We reviewed the effect of agent for osteoporosis on fracture healing. Bisphosphonates increased the callus volume, while delaying remodeling of the callus woven bone into lamellar bone, which is structurally and mechanically superior to woven bone. Selective estrogrn receptor modulator mildly suppressed callus remodeling, which had no effect on fracture repair and intrinsic material properties. Intermittent treatment of parathyroid hormone accelerated the healing process as evidenced by earlier replacement of woven bone to lamellar bone, increased new cortical shell formation, and increased the ultimate load.
Komatsubara
Satoshi
S
Department of Orthopedic Surgery, Faculty of medicine, Kagawa University.
Mori
Satoshi
S
D000818:Animals; D001842:Bone and Bones / Q000502:physiology*; D004164:Diphosphonates / Q000494:pharmacology; D005260:Female; D017102:Fracture Healing / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D010281:Parathyroid Hormone / Q000494:pharmacology; D020845:Selective Estrogen Receptor Modulators / Q000494:pharmacology
D004164:Diphosphonates; D010281:Parathyroid Hormone; D020845:Selective Estrogen Receptor Modulators