Anticancer activity of some isothiazolo[5,4-b]pyridine derivatives.
Two small series of derivatives of isothiazolopyridine with the tertiary amine base center bridged through a methylene or 2-hydroxypropylene chain were tested in vitro for anticancer activity. The results of the preliminary studies showed that the compounds, especially those with a 2-hydroxypropylene spacer, exhibited a broad spectrum of anticancer action observed at a concentration of approximately 20 mM/L at the GI50 level.
Swiatek
Piotr
P
Department of Chemistry of Drugs, Wrocław Medical University, 1 Tamka Str., 50-137 Wrocław.
Malinka
Wiesław
W
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
D000970:Antineoplastic Agents; D011725:Pyridines; D013844:Thiazoles