Tumor suppressor activities of the Fbw7 E3 ubiquitin ligase receptor.
The F-box protein Fbw7/Sel-10/hCdc4/Ago, which is known to regulate ubiquitination and degradation of numerous important regulators of cell division and death including Notch, cyclin E, c-Jun and c-Myc, has been recently rediscovered as a p53-dependent tumor suppressor. Delineation of the mechanisms of Fbw7 anti-oncogenic activities and of its inactivation in human cancers is expected to gain an important insight into tumorigenesis.
Fuchs
Serge Y
SY
Department of Animal Biology, University of Pennsylvania, Philadelphia, PA 19104-6046, USA. syfuchs@vet.upenn.edu
D000818:Animals; D044783:F-Box Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D051379:Mice; D016755:Proto-Oncogene Proteins c-jun / Q000235:genetics / Q000378:metabolism; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics / Q000378:metabolism; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000235:genetics / Q000378:metabolism*
D044783:F-Box Proteins; D016755:Proto-Oncogene Proteins c-jun; D016271:Proto-Oncogene Proteins c-myc; D051880:Receptors, Notch; D025521:Tumor Suppressor Proteins; D044767:Ubiquitin-Protein Ligases