title: Nitric oxide (NO) production inhibitory constituents of Tabebuia avellanedae from Brazil.
abstract: From the water extract of Brazilian Tabebuia avellanedae, two new iridoids (1, 2) and a new phenylethanoid glycoside (3) have been isolated together with twelve known compounds (4-15). Their structures were determined based on the spectroscopic data. The isolated compounds inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. Compounds 1, 3, 10, 11, and 12 showed inhibitory activities more potent (IC50, 13.8-26.1 microg/ml) than a positive control N(G)-monomethyl-L-arginine (L-NMMA; IC50, 27.4 microg/ml).
authors.affiliation: Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Suresh
authors.initials: S
authors.lastname: Awale
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Kawakami
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Tezuka
authors.forename: Jun-Ya
authors.initials: JY
authors.lastname: Ueda
authors.forename: Ken
authors.initials: K
authors.lastname: Tanaka
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Kadota
mesh_terms: D001938:Brazil; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D029663:Tabebuia
chemical_list: D010936:Plant Extracts; D009569:Nitric Oxide