title: Ultra-short metformin pretreatment for clomiphene citrate-resistant polycystic ovary syndrome.
abstract: OBJECTIVE
  To evaluate the effect of ultra-short (12 days) metformin pretreatment in clomiphene-citrate (CC) resistant polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Eighty women with CC-resistant PCOS were randomly allocated to metformin pretreatment or usual treatment. Forty women received 1500 mg metformin daily for 12 days, followed by clomiphene 150 mg daily for 5 days along with metformin. Forty women (control group) received the same dose of clomiphene but no metformin pretreatment.
  
  
  RESULTS
  In the metformin group, 17 (42.5%) women ovulated, and 6 (15%) conceived. In the control group, 5 (12.5%) women ovulated but none conceived. Compared with the control group, the metformin group had significantly higher ovulation (P = 0.03) and pregnancy rates (P = 0.026).
  
  
  CONCLUSIONS
  Twelve days of metformin pretreatment improves ovulation and pregnancy rates in women with CC-resistant PCOS.
authors.affiliation: Department of Obstetrics and Gynecology, Mackay Memorial Hospital, No.92, Section 2, Chung-Shan North Road, Taipei, Taiwan. hu4416@yahoo.com
authors.forename: Y M
authors.initials: YM
authors.lastname: Hwu
authors.forename: S Y
authors.initials: SY
authors.lastname: Lin
authors.forename: W Y
authors.initials: WY
authors.lastname: Huang
authors.forename: M H
authors.initials: MH
authors.lastname: Lin
authors.forename: R K K
authors.initials: RK
authors.lastname: Lee
mesh_terms: D000328:Adult; D002996:Clomiphene / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008687:Metformin / Q000008:administration & dosage / Q000627:therapeutic use*; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy* / Q000473:pathology; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D005300:Fertility Agents, Female; D002996:Clomiphene; D008687:Metformin