[Influence of the stress induced by partial hepatectomy in the circadian liver regeneration].
Regeneration induced by partial hepetectomy is synchronized by the circadian variation of corticosterone that inhibits periodically the DNA synthesis. But, the amplitude and the postoperative delay of the first regenerating wave vary according to the nycthemeral time of the surgery that induces a powerful stress corticosterone release. Partial hepatectomy performed in the morning inhibits the subsequent corticosterone wave and the first DNA synthesis wave occurs early with a low amplitude. The same operation performed in the evening does not change the subsequent corticosterone wave and the first DNA synthesis wave is delayed but amplified. These results disprove the methodology used by many investigators: they sacrifice all the animals at the same nycthemeral time and perform operations at various delays before sacrifices in order to avoid the circadian synchronization.
Barbason
H
H
Université de Liège, cancérologie expérimentale, rue Belle-Maison no 7, 4877 OLNE, Belgique. Herve.Barbason@ulg.ac.be
D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D003345:Corticosterone / Q000097:blood; D006498:Hepatectomy; D008115:Liver Regeneration / Q000502:physiology*; D023421:Models, Animal; D013312:Stress, Physiological / Q000503:physiopathology
D003345:Corticosterone