[Effects of acetylsalicylic acid and diquertin on platelet aggregation and hemorheological parameters in rats with cerebral ischemia].
Rats with model cerebral ischemia were treated over 5 days with acetylsalicylic acid (in a single daily dose of 50 mg/kg via a gastric tube). This treatment decreased the level of platelet aggregation, while producing no statistically significant effect upon hemorheogical indices. The combined treatment with a complex of acetylsalicylic acid and diquertin (50 and 10 mg/kg via a gastric tube, respectively) also produced the antiaggregant effect, but additionally reduced the blood viscosity, erythrocyte aggregation, and fibrinogen content in the blood plasma.
Plotnikova
M B
MB
Iamkin
a V
aV
Aliev
O I
OI
Tiukavkina
N A
NA
D000818:Animals; D001241:Aspirin / Q000008:administration & dosage*; D001809:Blood Viscosity / Q000187:drug effects; D002545:Brain Ischemia / Q000097:blood* / Q000188:drug therapy; D004338:Drug Combinations; D004903:Erythrocyte Aggregation / Q000187:drug effects; D005337:Fibrin / Q000032:analysis; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D011794:Quercetin / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D051381:Rats; D017208:Rats, Wistar
D004338:Drug Combinations; D010975:Platelet Aggregation Inhibitors; C473100:diquertin; D005337:Fibrin; D011794:Quercetin; D001241:Aspirin