Nb-benzoyltryptamine derivatives with relaxant activity in guinea-pig ileum.
A series of derivatives analogous to Nb-benzoyltryptamine were synthesized by the Schotten-Bauman procedure. The products obtained were: Nb-4-methoxy-benzoyltryptamine, Nb-2,4-dimethoxy-benzoyltryptamine, Nb-3,4-dimethoxy-benzoyltryptamine, Nb-3,4-methylenedioxy-benzoyltryptamine and Nb-3,4,5-trimethoxy-benzoyltryptamine. They were characterized through the usual spectrometric methods (UV, IR, 1H and 13C NMR) and showed non-selective relaxant activity in guinea-pig ileum pre-contracted with acetylcholine, histamine and KCl.
Gutierrez
Stanley Juan C
SJ
Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, Cx. Postal 5009, 58051-970 João Pessoa, Paraíba, Brazil.
de S Claudino
Fladmir
F
Da Silva
Bagnólia A
BA
Câmara
Celso A
CA
de Almeida
Reinaldo N
RN
de Fátima V de Souza
Maria
M
Da Silva
Marcelo S
MS
Da-Cunha
Emídio V L
EV
Barbosa-Filho
José Maria
JM
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D004558:Electric Stimulation; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D006633:Histamine Antagonists / Q000494:pharmacology; D007082:Ileum / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D009126:Muscle Relaxation / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D011189:Potassium Chloride / Q000494:pharmacology; D013053:Spectrophotometry / Q000379:methods; D013329:Structure-Activity Relationship; D014363:Tryptamines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D006633:Histamine Antagonists; D014363:Tryptamines; D011189:Potassium Chloride; D006632:Histamine; D000109:Acetylcholine