title: Synthesis and evaluation of 6-hydroxy-7-methoxy-4-chromanone- and chroman-2-carboxamides as antioxidants.
abstract: A series of 6-hydroxy-7-methoxy-4-chromanone- (2a-e) and chroman-2-carboxamides (3a-e) were synthesized and their antioxidant activities were evaluated. While compounds 2a-e were less active, compounds 3a-e exhibited more potent inhibition of lipid peroxidation initiated by Fe(2+) and ascorbic acid in rat brain homogenates. Among them, N-arylsubstituted-chroman-2-carboxamides (3d and 3e) exhibited 25-40 times more potent inhibition than trolox (1). The DPPH radical scavenging activity of compound 3d was comparable to that of trolox.
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju, Republic of Korea. medchen@chungbuk.ac.kr
authors.forename: Heesoon
authors.initials: H
authors.lastname: Lee
authors.forename: Keumho
authors.initials: K
authors.lastname: Lee
authors.forename: Jae-Kyung
authors.initials: JK
authors.lastname: Jung
authors.forename: Jungsook
authors.initials: J
authors.lastname: Cho
authors.forename: Emmanuel A
authors.initials: EA
authors.lastname: Theodorakis
mesh_terms: D000880:Anthraquinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D002839:Chromans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002867:Chromones
chemical_list: D000880:Anthraquinones; D000975:Antioxidants; D002839:Chromans; D002867:Chromones; C469373:chaetomanone