title: [Expression of Fas antigen and ligand, placental growth factor in placenta of pregnant women with pre-eclampsia].
abstract: OBJECTIVE
  To investigate the expression of Fas antigen (Fas) and ligand (FasL), placental growth factor (PlGF) in placenta of pregnant women with pre-eclampsia.
  
  
  METHODS
  Expressions of Fas, FasL and PlGF of placenta were determined by immunohistological streptavidin-peroxidase-biotin (SP) method and compared between normal late pregnancy (24 cases) and mild pre-eclampsia (24 cases) and severe pre-eclampsia (24 cases) groups.
  
  
  RESULTS
  Different expression of levels Fas, FasL and PlGF were observed in the trophoblasts of most placentae. Positive immunostain of Fas, FasL and PlGF was mainly located in the cytoplasm and membrane of syncytiotrophoblast. FasL and PlGF expressions (63 +/- 4, 81 +/- 6 and 42 +/- 6, 65 +/- 6) were significantly less (P < 0.01), and Fas expression (51 +/- 4, 67 +/- 6) significantly greater in the study subjects compared with controls (P < 0.01).
  
  
  CONCLUSIONS
  Altered expression of Fas and FasL in trophoblasts of placenta may influence pathogenesis or sequelate of pre-eclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Third Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
authors.forename: Xiu-yun
authors.initials: XY
authors.lastname: Yue
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
authors.forename: Shi-hong
authors.initials: SH
authors.lastname: Cui
authors.forename: Xiu-qin
authors.initials: XQ
authors.lastname: Wang
mesh_terms: D000328:Adult; D053222:Fas Ligand Protein / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D006801:Humans; D010920:Placenta / Q000378:metabolism; D000072483:Placenta Growth Factor; D011225:Pre-Eclampsia / Q000235:genetics* / Q000378:metabolism; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000235:genetics* / Q000378:metabolism; D014327:Trophoblasts / Q000378:metabolism; D019014:fas Receptor / Q000235:genetics* / Q000378:metabolism
chemical_list: D053222:Fas Ligand Protein; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D019014:fas Receptor; D000072483:Placenta Growth Factor