[Successful treatment of severe post-partum bleeding after caesarean section using recombinant activated factor VII].
OBJECTIVE
To present a case report of severe post-partum bleeding after caesarean section and successful using recombinant factor VIIa.


METHODS
Department Obstetrics and Gynecology, Regional Hospital, Kladno, Czech Republic.


METHODS
A 28-year old nullipara presented with major post-partum bleeding after caesarean section due to uterine atony. The patient developed hemorrhagic shock, associated with disseminated intravascular coagulation (DIC). Treatment with uterotonics drug, prostaglandins, hysterectomy and packing of the pelvis failed to control diffuse pelvic and vaginal bleeding. Recombinant factor VIIa (2.4 mg intravenous injection) was given as a final attempt to control the bleeding before relaparotomy and ligation hypogastric artery. The response to treatment was rapid, with control of the bleeding and resolution of the coagulopathy.


CONCLUSIONS
This case suggests a potential role of recombination factor VIIa in the treatment of severe post-partum bleeding associated with DIC.
Holub
Z
Z
Gynekologicko-porodnické oddelení, Nemocnice Kladno.
Feyereisl
J
J
Kabelík
L
L
Rittstein
T
T
D000328:Adult; D002585:Cesarean Section / Q000009:adverse effects*; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D005167:Factor VII / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006473:Postpartum Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D011247:Pregnancy; D011994:Recombinant Proteins / Q000627:therapeutic use; D012771:Shock, Hemorrhagic / Q000209:etiology
D011994:Recombinant Proteins; D005167:Factor VII