title: [Tumorous diseases in patients with the testicular feminization syndrome ("androgen insensitivity" syndrome)--description of two cases].
abstract: OBJECTIVE
  To describe tumors occurring in two cases of testicular feminization syndrome.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Dpt. of Special Diagnostics SPAU, University Hospital Plzen.
  
  
  METHODS
  Two cases of testicular feminization syndrome were selected from four cases in our registry. Patients were 45 and 84-year-old Caucasian "females". Resected material was fixed in formaldehyde, routinely processed and stained with hematoxiline-eosin, inhibin, cytokeratines 20, placentar alkaline phosphatase, CD 99, Melan A, hCG. Sertoli cell adenoma was diagnosed in both patients. Older patient had in addition unclassified sex cord tumor of Leydig cell type. The number of sex chromosomes was examined using FISH analysis in both patients.
  
  
  CONCLUSIONS
  Patients with testicular feminization syndrome are frequently affected by benign or malignant tumors in the cryptorchid testes. We documented two benign Sertoli cell adenomas and one sex cord tumor of uncertain biological behavior in our patients. The testes should be removed after puberty with subsequent estrogen therapy in patients with testicular feminization syndrome.
authors.affiliation: Oddelení speciální diagnostiky SPAU, FN Plzen. hes@medima.cz
authors.forename: O
authors.initials: O
authors.lastname: Hes
authors.forename: T
authors.initials: T
authors.lastname: Vanecek
authors.forename: R
authors.initials: R
authors.lastname: Síma
authors.forename: M
authors.initials: M
authors.lastname: Hora
authors.forename: H
authors.initials: H
authors.lastname: Velickinová
authors.forename: P
authors.initials: P
authors.lastname: Grossmann
authors.forename: J
authors.initials: J
authors.lastname: Kovár
authors.forename: M
authors.initials: M
authors.lastname: Michal
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D013734:Androgen-Insensitivity Syndrome / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012707:Sertoli Cell Tumor / Q000150:complications*; D013736:Testicular Neoplasms / Q000150:complications*