Malaria parasite transporters as a drug-delivery strategy.
The recent characterization of the choline carrier of the malaria parasite and its role in the selective delivery of novel antimalarial drugs has reignited interest in parasite transporters as a drug-delivery strategy. In this article, we discuss these findings in relation to the wider context of developing a sustainable antimalarial-drug-development portfolio.
Biagini
Giancarlo A
GA
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK, L35 QA. biagini@liv.ac.uk
Ward
Stephen A
SA
Bray
Patrick G
PG
D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002462:Cell Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism / Q000469:parasitology*; D000882:Haplorhini; D006801:Humans; D008288:Malaria / Q000097:blood / Q000188:drug therapy*; D026901:Membrane Transport Proteins / Q000378:metabolism*; D010961:Plasmodium / Q000378:metabolism*
D000962:Antimalarials; D026901:Membrane Transport Proteins; C065637:choline transporter