[Possibility probe on glucocorticoid treating primary child epistaxis].
OBJECTIVE
To probe the curative effect of glucocorticoid (GCD) on primary child epistaxis (PCE).


METHODS
(1) Make rabbit model with nasal allergic reaction and nasal septum mucosa erosion, by dropping nose with toluene diisocyanate then curettaging front-middle-part of nasal septum mucosa. Divide them into two groups dexamethasone group and antibiotics group. (2) Questioning investigate the relationship between PCE and nasal allergic reaction to 1000 school children. (3) Two hundred cases of nasal bleeding children were divided into two groups dexamethasone-therapy-group and control-group.


RESULTS
(1) The healing period of rabbit nasal septum mucosa is much shorter in dexamethasone group than in another group. (2) The genesis rate of school-children nasal bleeding is significantly higher in those with allergic rhinitis than in those without it. (3) The curative effect of therapy-group is much higher than that of control-group, there is significant difference.


CONCLUSIONS
There is close relationship between PCE and nasal allergic reaction. Nasal allergic reaction is one of the most important reasons for child epistaxis. Through inhibiting the allergic reaction, GCD can promote the erosive nasal septum mucosa healing. GCD has great curative effect on PCE.
Xu
Xinmao
X
Department of Otolaryngology, Tengzhou Central People's Hospital, Shandong Province, Tengzhou, 277500, China. xinmaoxu@163.com
Ma
Yalin
Y
Zhang
Xindong
X
Chai
Maowen
M
D000818:Animals; D002648:Child; D002675:Child, Preschool; D003907:Dexamethasone / Q000627:therapeutic use*; D004844:Epistaxis / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011817:Rabbits; D012221:Rhinitis, Allergic, Perennial / Q000150:complications / Q000188:drug therapy
D005938:Glucocorticoids; D003907:Dexamethasone