title: A glycosidic isoflavonoid from Viola hondoensis W. BECKER et H. BOISSIEU (Violaceae), and its effect on the expression of matrix metalloproteinase-1 caused by ultraviolet irradiation in cultured human skin fibroblasts.
abstract: Isolation of the ethyl acetate soluble fraction from aerial parts of Viola hondoensis W. BECKER et H. BOISSIEU yielded one major isoflavonoid glycoside, tectoridin-4'-O-beta-D-glucoside. The structure of the compound was certainly determined by chemical analyses, as well as 1D- and 2D-NMR spectroscopy. The compound exhibited potent inhibitory activity against the expression of matrix metalloproteinase-1 caused by UV-irradiation in cultured human skin fibroblasts.
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, and Clinical Research Institute, Seoul National University Hospital, Korea. himun@snu.ac.kr
authors.forename: Hyung In
authors.initials: HI
authors.lastname: Moon
authors.forename: Joongku
authors.initials: J
authors.lastname: Lee
authors.forename: Ok Pyo
authors.initials: OP
authors.lastname: Zee
authors.forename: Jin Ho
authors.initials: JH
authors.lastname: Chung
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D005347:Fibroblasts / Q000187:drug effects* / Q000201:enzymology / Q000528:radiation effects*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects / Q000502:physiology; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007529:Isoflavones / Q000302:isolation & purification / Q000494:pharmacology*; D020781:Matrix Metalloproteinase 1 / Q000096:biosynthesis* / Q000528:radiation effects; D061965:Matrix Metalloproteinase Inhibitors; D051379:Mice; D041681:NIH 3T3 Cells; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D014466:Ultraviolet Rays / Q000009:adverse effects*; D032413:Viola
chemical_list: D006027:Glycosides; D007529:Isoflavones; D061965:Matrix Metalloproteinase Inhibitors; D010936:Plant Extracts; D020781:Matrix Metalloproteinase 1