A long-term survival case of small cell lung cancer in an HIV-infected patient.
We report a case of small cell lung cancer in a patient with human immunodeficiency virus (HIV) infection. The patient was a 51-year-old man diagnosed 8 years previously as seropositive for HIV, who was admitted to our hospital for re-evaluation of antiretroviral medications due to multidrug resistance. Chest radiograph revealed an abnormal hilar shadow subsequently confirmed to be small cell lung cancer. He received chemotherapy concurrently with highly active antiretroviral therapy (HAART), and lived for 14 months after the diagnosis. The prognosis of lung cancer in HIV-seropositive patients is very poor, and adverse effects of chemotherapy occur more frequently than in other patients. However, the simultaneous antiretroviral agents and combination chemotherapy was successful. Such treatment may be effective despite an otherwise poor prognosis, including HIV infection.
Kato
Tetsuro
T
Division of Respiratory Disease, Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22, Hon-Komagome, Bunkyo-ku, Tokyo, 113-8677 Japan. katetsu@av5.mopera.ne.jp
Ieki
Ryuji
R
Saito
Erika
E
Ota
Tomohiro
T
Yuasa
Kazumi
K
Iguchi
Mari
M
Okamura
Tatsuru
T
Shibuya
Masahiko
M
D000480:Alkynes; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D048588:Benzoxazines; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002219:Carbamates; D016190:Carboplatin / Q000008:administration & dosage; D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D002945:Cisplatin / Q000008:administration & dosage; D003521:Cyclopropanes; D016049:Didanosine / Q000008:administration & dosage; D015224:Dideoxynucleosides / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005663:Furans; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D020276:HIV Long-Term Survivors; D006801:Humans; D000077146:Irinotecan; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010078:Oxazines / Q000008:administration & dosage; D019438:Ritonavir / Q000008:administration & dosage; D013449:Sulfonamides / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed; D000099227:Abacavir
D000480:Alkynes; D019380:Anti-HIV Agents; D048588:Benzoxazines; D002166:Camptothecin; D002219:Carbamates; D016190:Carboplatin; D002945:Cisplatin; D003521:Cyclopropanes; D016049:Didanosine; D015224:Dideoxynucleosides; D005663:Furans; D000077146:Irinotecan; D010078:Oxazines; D019438:Ritonavir; D013449:Sulfonamides; D000099227:Abacavir; C095108:amprenavir; C098320:efavirenz