title: Iberis amara L. and Iberogast--results of a systematic review concerning functional dyspepsia.
abstract: A systematic review referring to efficacy and tolerability of the herbal combination Iberogast (Iberis amara planta totalis, Chelidonii herba, Cardui mariae fructus, Melissae folium, Carvi fructus, Liquiritiae radix, Angelicae radix, Matricariae flos, Menthae piperitae folium) was performed in patients with functional dyspepsia. Three placebo-controlled trials and a reference-controlled trial showed a statistical significant and therapeutical relevant reduction of the gastrointestinal symptom-scores in 595 patients. The therapeutic efficacy was also found in one observational study (2267 patients). In accordance with the available evidence Iberogast seems to be an effective phytotherapeutic preparation to reduce the symptoms of dyspepsia yet, without central nervous side effects.
authors.affiliation: Department of Internal Medicine, Complementary Medicine, University Hospital, Rämistr. 100, 8091 Zurich, Switzerland. joerg.melzer@usz.ch
authors.forename: J
authors.initials: J
authors.lastname: Melzer
authors.forename: F
authors.initials: F
authors.lastname: Iten
authors.forename: J
authors.initials: J
authors.lastname: Reichling
authors.forename: R
authors.initials: R
authors.lastname: Saller
mesh_terms: D004415:Dyspepsia / Q000188:drug therapy*; D006801:Humans; D015337:Multicenter Studies as Topic; D017060:Patient Satisfaction; D008517:Phytotherapy; D010936:Plant Extracts; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D012449:Safety; D016896:Treatment Outcome
chemical_list: D010936:Plant Extracts; C039964:iberogast