title: Comparison of a small volume of hypertonic saline solution and dextran 40 on hemodynamic alternations in conscious calves.
abstract: The hemodynamic effects of rapid intravenous (IV) administration of 10% dextran 40 in saline solution (D40) and 7.2% hypertonic saline solution (HSS) in calves were compared. Calves received isotonic saline solution (ISS), HSS or D40 (3 calves/group) and were monitored of blood pressure, and cardiac output (CO) for 180 min. HSS and D40 infusions induced a significant increase in relative plasma volume reaching 134.9+/-2.8 and 125.0+/-1.9%, respectively at the end of fluid infusion. In the HSS group, CO, cardiac index (CI) and stroke volume (SV) remained constant at low levels after 90 minutes despite the maximal values of CO, CI and SV at the end of infusion, reaching 21.0+/-6.3 l/min (p<0.05), 177.8+/-14.2 ml/min/kg (p<0.001) and 0.20+/-0.03 l/beat (at t=10 min, p<0.001), respectively. In contrast, CI and SV in the D40 group showed significant increases to 14.7+/-2.9 l/min and 153.5+/-17.2 ml/min/kg, respectively, at the end of fluid infusion. And those values remained constant at higher levels than those of the before infusions values throughout the experimental periods. Positive effects for hemodynamic alternations of D40 in calf practice were milder and longer than those of HSS. Therefore, the D40 infusion should be explored as a possible treatment for dehydrated calves, since rapid infusion of D40 may be safe and more beneficial for rehydrating more than HSS treatment.
authors.affiliation: Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa, Japan. kazuyuki@brs.nihon-u.ac.jp
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Suzuki
authors.forename: Tomoko
authors.initials: T
authors.lastname: Suzuki
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Miyahara
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Iwabuchi
authors.forename: Ryuji
authors.initials: R
authors.lastname: Asano
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D002712:Chlorides / Q000097:blood; D003911:Dextrans / Q000008:administration & dosage*; D006339:Heart Rate / Q000187:drug effects; D020896:Hypovolemia / Q000097:blood / Q000473:pathology / Q000503:physiopathology / Q000628:therapy* / Q000662:veterinary*; D007262:Infusions, Intravenous / Q000662:veterinary; D010952:Plasma Substitutes / Q000008:administration & dosage*; D010953:Plasma Volume / Q000662:veterinary; D011188:Potassium / Q000097:blood; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage*; D012964:Sodium / Q000097:blood
chemical_list: D002712:Chlorides; D003911:Dextrans; D010952:Plasma Substitutes; D012462:Saline Solution, Hypertonic; D012964:Sodium; D011188:Potassium