[Biotransformation of mexidol in inbred BALB/C and C57BL/6 mice].
The pharmacokinetics and biotransformation of mexidol was studied in BALB/C and C57BL/6 mice. The blood plasma contains dealkylated metabolites, and the urine contains glucuronoconjugated derivatives of the drug. The process of glucuronoconjugation more intensively proceeds in C57BL/6 mice than in BALB/C mice.
Seredenin
S B
SB
Kravtsova
O Iu
OIu
Sarieva
A K
AK
Zherdev
V P
VP
Kolyvanova
G B
GB
Voronina
T A
TA
D000818:Animals; D001711:Biotransformation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010847:Picolines / Q000493:pharmacokinetics*; D011619:Psychotropic Drugs / Q000493:pharmacokinetics*; D013045:Species Specificity; D014018:Tissue Distribution
D010847:Picolines; D011619:Psychotropic Drugs; C070020:emoxypine succinate