Cancer preventive agents, Part 2: Synthesis and evaluation of 2-phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives as novel antitumor promoters.
2-Phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives were synthesized and screened as potential antitumor promoters by examining the ability of the compounds to inhibit Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. Interestingly, compounds 14, 15, and 17 showed similar inhibitory effects (89-92%, 66-69%, and 24-29% at 1000, 500, and 100 mol ratio to TPA, respectively) against EBV-EA with potencies comparable to those of glycyrrhetic acid, a known natural antitumor-promoter.
Nakamura
Seikou
S
Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.
Kozuka
Mutsuo
M
Bastow
Kenneth F
KF
Tokuda
Harukuni
H
Nishino
Hoyoku
H
Suzuki
Madoka
M
Tatsuzaki
Jin
J
Morris Natschke
Susan L
SL
Kuo
Sheng-Chu
SC
Lee
Kuo-Hsiung
KH
D000166:Acridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016588:Anticarcinogenic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
C504397:9-oxo-9,10-dihydroacridine; D000166:Acridines; D016588:Anticarcinogenic Agents; D015363:Quinolones; C084179:2-phenyl-4-oxohydroquinoline; D013755:Tetradecanoylphorbol Acetate