title: CLIPs and CLASPs and cellular dynamics.
abstract: The dynamic properties of microtubules are regulated by plus-end tracking proteins (+TIPs), which associate with the distal ends of microtubules. Among the +TIPs are cytoplasmic linker proteins (CLIPs), which promote microtubule growth and regulate dynein-dynactin localization, and CLIP-associating proteins (CLASPs), which stabilize specific subsets of microtubules on reception of signalling cues. CLIPs and CLASPs interact and cooperate to direct the microtubule network, thereby regulating cellular asymmetry.
authors.affiliation: Department of Cell Biology and Genetics, Erasmus Medical Centre, P.O. Box 1738, 3000 DR, Rotterdam, The Netherlands. n.galjart@erasmusmc.nl
authors.forename: Niels
authors.initials: N
authors.lastname: Galjart
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D016764:Cell Polarity; D003599:Cytoskeleton / Q000378:metabolism*; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008870:Microtubules / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D016415:Sequence Alignment
chemical_list: C497850:CLASP1 protein, human; C405804:EB1 microtubule binding proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; C076744:cytoplasmic linker protein 170