title: Amikacin and colistin for treatment of Acinetobacter baumannii meningitis.
abstract: We report a case of a 52-year-old man with post-surgical meningitis due to a multi-drug resistant Acinetobacter baumannii. Despite therapy with intravenous amikacin and imipenem the meningitis progressed. Upon institution of combination therapy with amikacin by the intravenous and intrathecal (IT) routes, and intravenous colistin the patient experienced successful clinical and microbiological outcomes.
authors.affiliation: Section of Infectious Diseases, Washington Hospital Center, 110 Irving Street, Washington, DC 20010, USA.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Fulnecky
authors.forename: Donald
authors.initials: D
authors.lastname: Wright
authors.forename: W Michael
authors.initials: WM
authors.lastname: Scheld
authors.forename: Lama
authors.initials: L
authors.lastname: Kanawati
authors.forename: Shmuel
authors.initials: S
authors.lastname: Shoham
mesh_terms: D000151:Acinetobacter Infections / Q000188:drug therapy*; D040981:Acinetobacter baumannii; D000583:Amikacin / Q000008:administration & dosage*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D003091:Colistin / Q000008:administration & dosage*; D024901:Drug Resistance, Multiple, Bacterial; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D006801:Humans; D007262:Infusions, Intravenous; D007278:Injections, Spinal; D008297:Male; D016920:Meningitis, Bacterial / Q000188:drug therapy*; D008875:Middle Aged; D017211:Treatment Failure
chemical_list: D000900:Anti-Bacterial Agents; D000583:Amikacin; D003091:Colistin