title: Quantitating progression in ALS.
abstract: The authors prospectively studied the value of clinical and neurophysiologic measurements in assessing progression in ALS. Motor unit number estimation (MUNE) and the neurophysiologic index (NI) were significantly correlated with ADM strength (maximal voluntary isometric contraction force in the abductor digiti minimi muscle [MVIC-ADM]). MUNE and the NI were reliable, but the NI showed a lower variation. On assessing progression at 3, 6, and 12 months, MUNE, NI, and MVIC-ADM showed the highest rate of change. The NI is a potentially useful new neurophysiologic measurement.
authors.affiliation: Department of Neurology, Hospital de Santa Maria, Laboratory of Electromyography, Centro de Estudos Egas Moniz, Faculty of Medicine, Institute of Molecular Medicine, Lisbon, Portugal. mamedemg@mail.telepac.pt
authors.forename: Mamede
authors.initials: M
authors.lastname: de Carvalho
authors.forename: Manuel
authors.initials: M
authors.lastname: Scotto
authors.forename: Arminda
authors.initials: A
authors.lastname: Lopes
authors.forename: Michael
authors.initials: M
authors.lastname: Swash
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis* / Q000503:physiopathology*; D018450:Disease Progression; D004568:Electrodiagnosis / Q000379:methods* / Q000592:standards / Q000639:trends; D005260:Female; D006225:Hand / Q000294:innervation / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology*; D009119:Muscle Contraction / Q000502:physiology; D018908:Muscle Weakness / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D018482:Muscle, Skeletal / Q000294:innervation / Q000503:physiopathology*; D009460:Neurologic Examination / Q000379:methods / Q000592:standards / Q000639:trends; D009482:Neurophysiology / Q000379:methods / Q000592:standards / Q000639:trends; D011237:Predictive Value of Tests; D011446:Prospective Studies