title: Relationship between the clinical heterogeneity of neurocysticercosis and the immune-inflammatory profiles.
abstract: Human neurocysticercosis is caused by the establishment of Taenia solium cysticerci in the central nervous system. Neurocysticercosis may be asymptomatic or manifested by non-specific mild to severe neurological symptoms. Host factors may be involved in this heterogeneous clinical picture. An immune-inflammatory profile that underlies neurocysticercosis presentation was determined in 45 cerebral spinal fluid (CSF), from clinical and radiologically characterized neurocysticercosis patients, measuring specific IgG subclasses and cytokines. Severity related with increased cellularity in the CSF which was characterized by increased levels of IgG subclasses, IL6/IL5/IL10, proteins, and eosinophils. Multiple neurocysticercosis showed higher levels of IL5/IL6 than single neurocysticercosis. Women presented increased IL6/IL5/IL10 levels pointing out immunological differences due to gender. Severe symptomatology was found when cysticerci were located intraventricular or in the subarachnoid space of the base, inducing an exacerbated response in the CSF. These results constitute an integrative insight to understand the immune-inflammatory response that underlies symptomatic neurocysticercosis.
authors.affiliation: Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, UNAM, AP70228, México D.F. 04510, México.
authors.forename: Anahí
authors.initials: A
authors.lastname: Chavarría
authors.forename: Agnes
authors.initials: A
authors.lastname: Fleury
authors.forename: Esperanza
authors.initials: E
authors.lastname: García
authors.forename: Carlos
authors.initials: C
authors.lastname: Márquez
authors.forename: Gladis
authors.initials: G
authors.lastname: Fragoso
authors.forename: Edda
authors.initials: E
authors.lastname: Sciutto
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000909:Antibodies, Helminth / Q000134:cerebrospinal fluid; D001921:Brain / Q000469:parasitology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid / Q000145:classification; D018836:Inflammation Mediators / Q000134:cerebrospinal fluid; D016753:Interleukin-10 / Q000134:cerebrospinal fluid; D015848:Interleukin-5 / Q000134:cerebrospinal fluid; D015850:Interleukin-6 / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D020019:Neurocysticercosis / Q000276:immunology* / Q000469:parasitology / Q000503:physiopathology; D012727:Sex Characteristics; D041201:Taenia solium / Q000276:immunology / Q000472:pathogenicity
chemical_list: D000909:Antibodies, Helminth; D007074:Immunoglobulin G; D018836:Inflammation Mediators; D015848:Interleukin-5; D015850:Interleukin-6; D016753:Interleukin-10