Antibacterial activity of dipropofol and related compounds.
Phenolic compounds, in general, exhibit antioxidant and antibacterial activities. We studied antimicrobial activity of the phenolic antioxidants, propofol (2,6-diisopropylphenol), tocopherol, eugenol, butylated hydroxyanisole (BHA), and several of their dimer compounds. Dipropofol (dimer of 2,6-diisopropylphenol) showed strong antibacterial activity against gram-positive strains including methicillin resistant Staphylococcus aureus (MRSA) and vancomycin resistant Enterococci (VRE), while propofol and other monomeric and dimeric phenols having methyl or tert-butyl groups showed no remarkable activity. The results indicated that the dimeric structure of 2,6-diisopropylphenol moiety may play an important role in the antibacterial activity.
Ogata
Masahiro
M
Kyoritsu University of Pharmacy, Tokyo, Japan. ogata-ms@aomori-u..ac.jp
Tutumimoto Sato
Kanae
K
Kunikane
Takao
T
Oka
Kentaro
K
Seki
Masako
M
Urano
Shiro
S
Hiramatsu
Keiichi
K
Endo
Toyoshige
T
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods; D015742:Propofol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development
D000900:Anti-Bacterial Agents; D015742:Propofol