Caffeic acid metabolites from Eritrichium sericeum cell cultures.
Eritrichium sericeum (Boraginaceae) callus and root cultures were established and analyzed for caffeic acid metabolite (CAM) production. Two substances, (-)-rabdosiin and rosmarinic acid, were identified as main CAMs produced by these cultures. The E. sericeum Er-1 root culture accumulated up to 1.5 % and 4.5 % DW of (-)-rabdosiin and rosmarinic acid, respectively. Rabdosiin in the Lithospermum erythrorhizon callus cultures was produced exclusively as the (+)-enantiomer while in both Eritrichium cultures it occurred as the (-)-enantiomer. The E. sericeum Er-1 culture accumulated 3-fold higher levels of CAMs than the L. erythrorhizon culture. A new compound, named eritrichin, was isolated from the cultured E. sericeum cells. The structure of this compound was established as (2R)-3-(3,4-dihydroxyphenyl)-2-[4-(3,4-dihydroxyphenyl)-6,7-dihydroxy-2-naphthoyloxy]propanoic acid on the basis of spectral data.
Fedoreyev
Sergey A
SA
Pacific Institute of Bioorganic Chemistry, Far East Branch of Russian Academy of Sciences, Vladivostok, Russian Federation. fedoreyev@mail.primorye.ru
Veselova
Marina V
MV
Krivoschekova
Olga E
OE
Mischenko
Natalia P
NP
Denisenko
Vladimir A
VA
Dmitrenok
Pavel S
PS
Glazunov
Valery P
VP
Bulgakov
Victor P
VP
Tchernoded
Galina K
GK
Zhuravlev
Yury N
YN
D028082:Boraginaceae / Q000737:chemistry / Q000378:metabolism*; D002109:Caffeic Acids / Q000737:chemistry / Q000378:metabolism*; D002478:Cells, Cultured; D006801:Humans; D008517:Phytotherapy; D018517:Plant Roots / Q000737:chemistry / Q000378:metabolism; D012639:Seeds / Q000737:chemistry / Q000378:metabolism
D002109:Caffeic Acids