Silver growth on micropatterned DNA chips: effect of growth conditions and morphology on I-V behavior.
An approach to the design of DNA-based electronics is presented, in which standard microfabrication processes are integrated with lithographic patterning of single-stranded oligonucleotides followed by hybridization to gold-labeled, complementary oligonucleotides and subsequent silver enhancement for signal amplification. The resulting bioinorganic devices demonstrate micron-sized geometric features, very little non-specific silver growth, a distinct silver morphology in the patterned region, and a 10(9)-fold increase in conductivity across an electrode gap when compared with control devices. This approach may prove useful for the fabrication of high fidelity, high-density arrays for DNA-based biosensing applications.
Greninger
Daniel A
DA
Materials Chemistry, Sandia National Laboratories, 7011 East Avenue, Livermore, California 94550-0969, USA.
Pathak
Srikant
S
Talin
A A
AA
Dentinger
Paul M
PM
D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D020099:Coated Materials, Biocompatible / Q000032:analysis / Q000737:chemistry*; D003460:Crystallization / Q000379:methods*; D004563:Electrochemistry / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D017403:In Situ Hybridization / Q000295:instrumentation* / Q000379:methods; D008839:Microelectrodes; D036103:Nanotechnology / Q000295:instrumentation* / Q000379:methods; D020411:Oligonucleotide Array Sequence Analysis / Q000295:instrumentation* / Q000379:methods; D012834:Silver / Q000032:analysis / Q000737:chemistry*
D020099:Coated Materials, Biocompatible; D012834:Silver