Methyl pyropheophorbide-a analogues: potential fluorescent probes for the peripheral-type benzodiazepine receptor. Effect of central metal in photosensitizing efficacy.
Pyropheophorbides and their metal complexes were synthesized to investigate their applications as nonradioactive peripheral benzodiazepine receptor (PBR) binding probes and photosensitizers for use in photodynamic therapy. They were found to be localized in mitochondria and showed significant binding to PBR. In some cases, the PBR binding values were similar to that for 17 (PK11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide). However, no direct correlation between 17 displacement ability and photosensitizing efficacy of photosensitizers was observed.
Chen
Yihui
Y
PDT Center, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
Zheng
Xiang
X
Dobhal
Mahabeer P
MP
Gryshuk
Amy
A
Morgan
Janet
J
Dougherty
Thomas J
TJ
Oseroff
Allan
A
Pandey
Ravindra K
RK
D000818:Animals; D007204:Indium; D007546:Isoquinolines / Q000494:pharmacology; D008024:Ligands; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D009532:Nickel; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011166:Porphyrins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured; D023041:Xenograft Model Antitumor Assays; D015032:Zinc
D007546:Isoquinolines; D008024:Ligands; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; D011166:Porphyrins; D011963:Receptors, GABA-A; C452939:pyropheophorbide-a methylester; D007204:Indium; D009532:Nickel; D015032:Zinc; C037850:PK 11195