title: [Rhythm of protein synthesis in cultures of hepatocytes from rats of different ages. Norm and effect of the peptide livagen].
abstract: The circumhoralian rhythm of protein synthesis was determined in a monolayer culture of hepatocytes from rats at the age of 1 to 24 months and weighing from 45 to 480 g, respectively. The peptide lyvagen (Lys-Glu-Asp-Ala) obtained by directed chemical synthesis on the basis of amino acid analysis of the liver polypeptide preparations increased the level of protein synthesis in the hepatocytes from rats of different ages; the highest effect was observed in the cells of old animals. In old rats, lyvagen increased the amplitude of protein synthesis fluctuations. The peptide epitalon (Ala-Glu-Asp-Gly) constructed on the basis of analysis of the epiphysis peptides did not change the intensity of protein synthesis in the cultured hepatocytes.
authors.forename: V Ia
authors.initials: VIa
authors.lastname: Brodskiĭ
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Zolotarev
authors.forename: N V
authors.initials: NV
authors.lastname: Nechaeva
authors.forename: V V
authors.initials: VV
authors.lastname: Malinin
authors.forename: T E
authors.initials: TE
authors.lastname: Novikova
authors.forename: I G
authors.initials: IG
authors.lastname: Gvazava
authors.forename: V I
authors.initials: VI
authors.lastname: Fateeva
mesh_terms: D000367:Age Factors; D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D002478:Cells, Cultured; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism*; D009841:Oligonucleotides / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology; D014176:Protein Biosynthesis / Q000187:drug effects*; D051381:Rats
chemical_list: C473185:Livagen; D009841:Oligonucleotides; D009842:Oligopeptides; C421253:alanyl-glutamyl-aspartyl-glycine