title: Crescentic post-streptococcal glomerulonephritis with nephrotic syndrome in the adult: is aggressive therapy warranted?
abstract: The prognosis for adults with acute post-streptococcal glomerulonephritis (PSGN) who present with crescentic glomerulonephritis and nephrotic proteinuria is not known. We report a patient with rapidly progressive glomerulonephritis and nephrotic-range proteinuria following acute pharyngitis, in whom serologic and kidney biopsy findings led to a diagnosis of PSGN. The patient was treated with corticosteroids and anti-hypertensive medications resulting in improvement in renal function and decrease in proteinuria. These results suggest that aggressive treatment of crescentic PSGN with nephrotic syndrome can result in a favorable outcome.
authors.affiliation: Renal Division, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA.
authors.forename: A
authors.initials: A
authors.lastname: Raff
authors.forename: T
authors.initials: T
authors.lastname: Hebert
authors.forename: J
authors.initials: J
authors.lastname: Pullman
authors.forename: M
authors.initials: M
authors.lastname: Coco
mesh_terms: D000284:Administration, Oral; D001707:Biopsy, Needle; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D005921:Glomerulonephritis / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007262:Infusions, Intravenous; D007677:Kidney Function Tests; D008775:Methylprednisolone / Q000008:administration & dosage*; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D011241:Prednisone / Q000008:administration & dosage; D020551:Pulse Therapy, Drug; D018570:Risk Assessment; D012720:Severity of Illness Index; D013290:Streptococcal Infections / Q000150:complications* / Q000175:diagnosis; D016896:Treatment Outcome
chemical_list: D011241:Prednisone; D008775:Methylprednisolone