Associations between whole-blood serotonin and subjective mood in healthy male volunteers.
Little is known regarding the relationship between how mood is experienced and biochemical factors. This research has explored potential relationships between whole-blood serotonin (5-HT) and subjective mood, measured using the Positive and Negative Affect Schedule (PANAS), in healthy males (n=23). Univariate linear regression analysis indicated that 5-HT levels were positively related to positive affect (P=0.002) but not negative affect. Whole-blood 5-HT concentrations therefore appear to predict mood in healthy males. More research using larger samples and including females is needed to explore further associations between biomarkers and subjective measures of mood.
Williams
Emma
E
Northern Ireland Centre for Food and Health (NICHE), University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK.
Stewart-Knox
Barbara
B
Helander
Anders
A
McConville
Christopher
C
Bradbury
Ian
I
Rowland
Ian
I
D000339:Affect / Q000502:physiology*; D006801:Humans; D008297:Male; D012701:Serotonin / Q000097:blood*
D012701:Serotonin