title: HESA-A: new treatment for breast cancer and choroidal metastasis.
abstract: BACKGROUND
  Breast cancer is one of the main causes of mortality among women worldwide. This type of cancer metastasizes to different body tissues, giving rise to many problems. The effect of HESA-A, a drug of herbal-marine origin, on vision, quality of life, and survival of end-stage breast cancer patients was investigated in this study.
  
  
  METHODS
  In a double-blind study, 24 breast cancer patients with choroidal metastasis, aged between 41 and 49 years, were divided into case and control groups, treated with 50 mg/kg/day of HESA-A and placebo, respectively. The patients were evaluated in respect to the intensity of experienced pain, by assessing their rate of narcotic analgesic use. The patients' vision scale was also evaluated.
  
  
  RESULTS
  Notable improvement was seen in the vision of patients treated with HESA-A. Patients receiving HESA-A used narcotics at lower doses, owing to reduced experience of pain. No changes were observed in the vision of control group patients, or their pain experience.
  
  
  CONCLUSIONS
  The effects of natural compounds with antioxidant and anticancer properties have been emphasized by different studies. HESA-A is a compound of natural origin, consisting of rare elements and organic materials, which in several animal and cellular studies has shown powerful anticancer effects and less toxicity on normal cells. The results of this study showed considerable improvement in the vision of breast cancer patients treated with HESA-A.
authors.affiliation: Cancer Institute Research Center, Tehran University of Medical Sciences, Tehran, Iran. ahmadi@isfahan.ir
authors.forename: Amrollah
authors.initials: A
authors.lastname: Ahmadi
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Mohagheghi
authors.forename: Mohammad Sadegh
authors.initials: MS
authors.lastname: Fazeli
authors.forename: Bijan
authors.initials: B
authors.lastname: Nahavandian
authors.forename: Nasrollah
authors.initials: N
authors.lastname: Bashardoost
authors.forename: Alireza
authors.initials: A
authors.lastname: Musavi Jarahi
authors.forename: Marjan
authors.initials: M
authors.lastname: Gharipoor
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000473:pathology / Q000556:secondary; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology*; D002830:Choroid Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000503:physiopathology / Q000556:secondary*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008875:Middle Aged; D010146:Pain / Q000517:prevention & control; D018579:Patient Selection; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*; D016019:Survival Analysis; D014786:Vision Disorders / Q000209:etiology; D014785:Vision, Ocular / Q000502:physiology
chemical_list: C502848:HESA-A preparation; D028321:Plant Preparations