Novel molecular drug carrier: encapsulation of oxaliplatin in cucurbit[7]uril and its effects on stability and reactivity of the drug.
Oxaliplatin forms a stable 1:1 inclusion complex with cucurbit[7]uril as indicated by NMR, mass spectrometry, isothermal titration calorimetry and X-ray crystallography. The encapsulation of the drug results in a large enhancement in stability, a moderate decrease in reactivity toward guanosine but a much larger decrease in reactivity toward L-methionine, which suggests the encapsulation not only increases the stability of the drug but also may reduce unwanted side effects caused by protein binding of the platinum drug. A preliminary in vitro assay using various tumor cell lines reveals that the encapsulation results in a decrease in the antitumor activity of oxaliplatin.
Jeon
Young Jin
YJ
National Creative Research Initiative Center for Smart Supramolecules, Division of Molecular and Life Sciences, Pohang University of Science and Technology San 31 Hyojadong, Pohang 790-784, Republic of Korea.
Kim
Soo-Young
SY
Ko
Young Ho
YH
Sakamoto
Shigeru
S
Yamaguchi
Kentaro
K
Kim
Kimoon
K
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D001952:Bridged-Ring Compounds / Q000737:chemistry*; D002151:Calorimetry; D018360:Crystallography, X-Ray; D004337:Drug Carriers; D004355:Drug Stability; D006151:Guanosine / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008715:Methionine / Q000737:chemistry; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000494:pharmacology; D000077150:Oxaliplatin; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
D000970:Antineoplastic Agents; D001952:Bridged-Ring Compounds; D004337:Drug Carriers; D006151:Guanosine; D007093:Imidazoles; D008715:Methionine; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; C456276:cucurbit(7)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils