title: [Effects of delayed opening of infarct-related artery on late left ventricular remodeling in patients with acute anterior myocardial infarction].
abstract: OBJECTIVE
  To assess the effect of delayed opening of the infarct-related artery (IRA) by percutaneous coronary intervention (PCI) on the late left ventricular remodeling after acute anterior myocardial infarction (AAMI).
  
  
  METHODS
  Sixty four patients with initial Q-wave AAMI and with the total occluded IRA conformed by angiogram at 9.1 +/- 2.3 (2 - 14) days after the onset were divided into successful PCI group and control group (not receiving PCI or the IRA not re-opened). Two-D echocardiogram was performed at acute phase (about 3 weeks), 2 and 6 months after onset of AAMI respectively to detect the left ventricular function and left ventricular wall motion abnormality (VWMA). The total congestive heart failure events were recorded during 6 months follow-up.
  
  
  RESULTS
  VWMA scores, left ventricular ejection fraction (LVEF), left ventricular end-diastolic and end-systolic volume indexes (LVEDVI and LVESVI) were similar in 2 groups at acute phase and 2 months after the onset of AAMI. There were no differences between the parameters above at acute phase and 2 months in each group too. VWMA scores and LVEF did not changed significantly at 6 months in each group compared with those at acute phase and 2 months (P > 0.05). But LVEDVI and LVESVI were significantly smaller in the successful PCI group than those in the control group (P < 0.01, P < 0.05). The rate of congestive heart failure events was 19% in control group and 2.0% in successful PCI group (P > 0.05) respectively.
  
  
  CONCLUSIONS
  Delayed opening of IRA in AAMI could prevent the late phase but not the early phase of left ventricular remodeling after AMI.
authors.affiliation: Department of Cardiology, Anhui Provincial Hospital, Hefei 230001, China. Malk2002cn@yahoo.com.cn
authors.forename: Li-kun
authors.initials: LK
authors.lastname: Ma
authors.forename: Hua
authors.initials: H
authors.lastname: Yu
authors.forename: Xiang-yang
authors.initials: XY
authors.lastname: Huang
authors.forename: Jun
authors.initials: J
authors.lastname: Zhu
authors.forename: Ke-fu
authors.initials: KF
authors.lastname: Feng
authors.forename: Shi-guang
authors.initials: SG
authors.lastname: Li
authors.forename: Xiao-hong
authors.initials: XH
authors.lastname: Zhang
authors.forename: Zheng-bin
authors.initials: ZB
authors.lastname: Shao
authors.forename: Xiao-mei
authors.initials: XM
authors.lastname: Ding
authors.forename: Ji
authors.initials: J
authors.lastname: Yan
authors.forename: Tong-yuan
authors.initials: TY
authors.lastname: Gu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D015425:Myocardial Reperfusion; D020257:Ventricular Remodeling