title: Short stricture of the rectum regressing on discontinuation of hormone replacement therapy: endoscopic appearance, multiple biopsies and clinical improvement insufficient for diagnosis.
abstract: A short, benign-looking stricture of the rectum presented itself clinically as subileus in a middle-aged woman after 5 years on hormone replacement therapy (HRT) and 8 years after curative surgery for cancer of the ovaries. Radiological work-up and multiple, repeated biopsies supported the endoscopically appearing benign nature of the lesion, and the stricture subsided after discontinuation of HRT. Re-introduction of HRT again caused subileus. At surgery, there was no suspicion of malignant disease. Histological examination of the resection specimen did, however, show metastasis from the ovarian cancer.
authors.affiliation: Telemark Hospital, Skien, Norway. hofg@online.no
authors.forename: Geir
authors.initials: G
authors.lastname: Hoff
authors.forename: Johan
authors.initials: J
authors.lastname: Wiig
authors.forename: Wenche
authors.initials: W
authors.lastname: Reed
authors.forename: Knut Håkon
authors.initials: KH
authors.lastname: Hole
authors.forename: Marit
authors.initials: M
authors.lastname: Scheistrøen
authors.forename: Halvor
authors.initials: H
authors.lastname: Henriksen
mesh_terms: D000328:Adult; D001706:Biopsy; D003113:Colonoscopy; D003251:Constriction, Pathologic; D003937:Diagnosis, Differential; D004958:Estradiol / Q000009:adverse effects*; D005260:Female; D020249:Hormone Replacement Therapy / Q000009:adverse effects*; D006801:Humans; D008279:Magnetic Resonance Imaging; D012002:Rectal Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D004958:Estradiol