[Study on ultra-structural pathological changes of rats poisoned by tetramine].
OBJECTIVE
To observe ultra-structural pathological changes of materiality viscera of rats poisoned by different dose of tetramine and to study the toxic mechanism.


METHODS
Acute and subacute tetramine toxicity models were made by oral administration with different dose of tetramine. Brain, heart, liver, spleen and kidney were extracted and observed by electromicroscopic examination.


RESULTS
The injuries of brain cells, cardiocytes and liver cells were induced by different dose of tetramine. These were not obviously different of the injuries of the kindy cells and spleen cells of rats poisoned by different dose of tetramine. Ultra-structural pathological changes were abserved including mitochondria slight swelling and neurolemma's array turbulence in the brain cells, mitochondria swelling or abolish and rupture of muscle fiber in the heart cells, mitochondria swelling and the glycogen decreased in the liver cells.


CONCLUSIONS
The toxic target organs of tetramine are the heart, brain and liver.
Zhi
Chuan-hong
CH
Department of Medicolegal, Tongji Medical College, Huazhong Science and Technology University, Wuhan 430030, China.
Liu
Liang
L
Liu
Yan
Y
D000818:Animals; D001921:Brain / Q000473:pathology*; D001952:Bridged-Ring Compounds / Q000506:poisoning*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008099:Liver / Q000473:pathology*; D008297:Male; D046529:Microscopy, Electron, Transmission; D008929:Mitochondria, Heart / Q000473:pathology; D008930:Mitochondria, Liver / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D011041:Poisoning / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D001952:Bridged-Ring Compounds; C010349:tetramethylenedisulfotetramine