[Effects of Accupro on structural and hemodynamic changes in patients with chronic heart failure].
The efficacy of angiotensin converting-enzyme inhibitors in the therapy of chronic heart failure are well documented and is mainly explained by a decrease of afterload via reduction of angiotensin II formation in the vascular system and myocardium. The aim of our study was to study the effectiveness of ACCUPRO on structural and hemodynamic indices in patients with heart failure. 37 patients aged 61-84 years with postinfarction cardiosclerosis and mild or moderate hypertension, class I-III heart failure received Accupro (13,7+/-0,97 mg/day) for 3 months in combination with furosemide (40-80 mg 1-3 times a week). The treatment with Accupro and diuretics was associated with corrective effect on left ventricular and diastolic dimension, increases of left ventricular ejection fraction and cardiac index. Left ventricular diastolic function improved in more than two thirds of patients. Positive dynamics of structural-functional state of the heart was accompanied with lowering of total peripheral resistance. Our results indicates that Accupro has positive effects in treatment of chronic heart failure.
Tabidze
G
G
Insitute of Cardiology, Tbilisi, Georgia.
Iakobashvili
M
M
Kobaladze
N
N
Bagaturia
D
D
Tsibadze
T
T
D000368:Aged; D000369:Aged, 80 and over; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D004232:Diuretics / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D015150:Echocardiography, Doppler; D005260:Female; D005500:Follow-Up Studies; D005665:Furosemide / Q000627:therapeutic use; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology; D016896:Treatment Outcome; D016277:Ventricular Function, Left / Q000187:drug effects* / Q000502:physiology
D000806:Angiotensin-Converting Enzyme Inhibitors; D004232:Diuretics; D005665:Furosemide