title: A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer.
abstract: We examined the coding sequence of 518 protein kinases, approximately 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.
authors.affiliation: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
authors.forename: Philip
authors.initials: P
authors.lastname: Stephens
authors.forename: Sarah
authors.initials: S
authors.lastname: Edkins
authors.forename: Helen
authors.initials: H
authors.lastname: Davies
authors.forename: Chris
authors.initials: C
authors.lastname: Greenman
authors.forename: Charles
authors.initials: C
authors.lastname: Cox
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authors.lastname: Hunter
authors.forename: Graham
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authors.lastname: Bignell
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authors.lastname: Teague
authors.forename: Raffaella
authors.initials: R
authors.lastname: Smith
authors.forename: Claire
authors.initials: C
authors.lastname: Stevens
authors.forename: Sarah
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authors.lastname: O'Meara
authors.forename: Adrian
authors.initials: A
authors.lastname: Parker
authors.forename: Patrick
authors.initials: P
authors.lastname: Tarpey
authors.forename: Tim
authors.initials: T
authors.lastname: Avis
authors.forename: Andy
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authors.lastname: Barthorpe
authors.forename: Lisa
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authors.lastname: Brackenbury
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authors.lastname: Buck
authors.forename: Adam
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authors.lastname: Butler
authors.forename: Jody
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authors.lastname: Clements
authors.forename: Jennifer
authors.initials: J
authors.lastname: Cole
authors.forename: Ed
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authors.lastname: Dicks
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authors.lastname: Edwards
authors.forename: Simon
authors.initials: S
authors.lastname: Forbes
authors.forename: Matthew
authors.initials: M
authors.lastname: Gorton
authors.forename: Kristian
authors.initials: K
authors.lastname: Gray
authors.forename: Kelly
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authors.lastname: Halliday
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authors.lastname: Harrison
authors.forename: Katy
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authors.lastname: Hills
authors.forename: Jonathon
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authors.lastname: Hinton
authors.forename: David
authors.initials: D
authors.lastname: Jones
authors.forename: Vivienne
authors.initials: V
authors.lastname: Kosmidou
authors.forename: Ross
authors.initials: R
authors.lastname: Laman
authors.forename: Richard
authors.initials: R
authors.lastname: Lugg
authors.forename: Andrew
authors.initials: A
authors.lastname: Menzies
authors.forename: Janet
authors.initials: J
authors.lastname: Perry
authors.forename: Robert
authors.initials: R
authors.lastname: Petty
authors.forename: Keiran
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authors.lastname: Raine
authors.forename: Rebecca
authors.initials: R
authors.lastname: Shepherd
authors.forename: Alexandra
authors.initials: A
authors.lastname: Small
authors.forename: Helen
authors.initials: H
authors.lastname: Solomon
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Stephens
authors.forename: Calli
authors.initials: C
authors.lastname: Tofts
authors.forename: Jennifer
authors.initials: J
authors.lastname: Varian
authors.forename: Anthony
authors.initials: A
authors.lastname: Webb
authors.forename: Sofie
authors.initials: S
authors.lastname: West
authors.forename: Sara
authors.initials: S
authors.lastname: Widaa
authors.forename: Andrew
authors.initials: A
authors.lastname: Yates
authors.forename: Francis
authors.initials: F
authors.lastname: Brasseur
authors.forename: Colin S
authors.initials: CS
authors.lastname: Cooper
authors.forename: Adrienne M
authors.initials: AM
authors.lastname: Flanagan
authors.forename: Anthony
authors.initials: A
authors.lastname: Green
authors.forename: Maggie
authors.initials: M
authors.lastname: Knowles
authors.forename: Suet Y
authors.initials: SY
authors.lastname: Leung
authors.forename: Leendert H J
authors.initials: LH
authors.lastname: Looijenga
authors.forename: Bruce
authors.initials: B
authors.lastname: Malkowicz
authors.forename: Marco A
authors.initials: MA
authors.lastname: Pierotti
authors.forename: Bin
authors.initials: B
authors.lastname: Teh
authors.forename: Siu T
authors.initials: ST
authors.lastname: Yuen
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Nicholson
authors.forename: Sunil
authors.initials: S
authors.lastname: Lakhani
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Easton
authors.forename: Barbara L
authors.initials: BL
authors.lastname: Weber
authors.forename: Michael R
authors.initials: MR
authors.lastname: Stratton
authors.forename: P Andrew
authors.initials: PA
authors.lastname: Futreal
authors.forename: Richard
authors.initials: R
authors.lastname: Wooster
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics*; D018270:Carcinoma, Ductal, Breast / Q000235:genetics*; D004252:DNA Mutational Analysis; D005260:Female; D006801:Humans; D005810:Multigene Family; D009154:Mutation; D011494:Protein Kinases / Q000235:genetics*
chemical_list: D011494:Protein Kinases