title: Hyperbaric oxygen therapy in the treatment of complications of irradiation in head and neck area.
abstract: OBJECTIVE
  We have investigated the treatment results of hyperbaric oxygen (HBO2) to patients with radiation-induced tissue complications.
  
  
  METHODS
  Eight patients (1.4%) from 548 with head and neck cancers treated surgically with post- or preoperative radiotherapy or radiotherapy alone in standard doses who developed postradiation complications (6 patients with laryngeal chondroradionecrosis, 1 patient with osteoradionecrosis of the temporal bone, and 1 patient with soft tissue radionecrosis) are presented. To evaluate radiation reactions occuring in the head and neck region, we used the Chandler grading system for classification of postradiation larynx injuries and SOMA/LENT score for classification of postradiation injuries of mucosa of upper aerodigestive tract. Grades I and II in those grading systems are expected side effects of radiation therapy, thus our cases were all in grades III and IV. The HBO2 was performed after failure of the conventional treatment (antibiotics, steroids, topical therapy). The number of HBO2 expositions was from 8 to 39 and the delay to therapy from 2 to 22 months.
  
  
  RESULTS
  Symptoms resolved in all treated patients. Six patients with laryngeal chondroradionecrosis had no symptoms after therapy and in three of them after partial laryngectomy the decannulation was performed. In one patient with mucosal radionecrosis after total laryngectomy, the esophageal fistula was closed and in one patient with osteoradionecrosis of the temporal bone, wound debridement followed.
  
  
  CONCLUSIONS
  The authors' experience supports the increasing clinical evidence that HBO2 is an effective adjunct therapy for treatment of complications of irradiation in head and neck area.
authors.affiliation: ENT Department Medical University of Gdansk, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Narozny
authors.forename: Z
authors.initials: Z
authors.lastname: Sicko
authors.forename: J
authors.initials: J
authors.lastname: Kot
authors.forename: C
authors.initials: C
authors.lastname: Stankiewicz
authors.forename: T
authors.initials: T
authors.lastname: Przewozny
authors.forename: J
authors.initials: J
authors.lastname: Kuczkowski
mesh_terms: D000328:Adult; D005260:Female; D005402:Fistula / Q000628:therapy; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000379:methods*; D007818:Laryngeal Diseases / Q000628:therapy; D007822:Laryngeal Neoplasms / Q000532:radiotherapy*; D007830:Larynx / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D010025:Osteoradionecrosis / Q000628:therapy; D010608:Pharyngeal Diseases / Q000628:therapy; D011832:Radiation Injuries / Q000628:therapy*; D012189:Retrospective Studies; D012888:Skull Neoplasms / Q000532:radiotherapy*; D013701:Temporal Bone / Q000528:radiation effects; D014067:Tonsillar Neoplasms / Q000532:radiotherapy