A tuneable method for N-debenzylation of benzylamino alcohols.
[reactions: see text] N-Iodosuccinimide provides a mild, convenient, and tuneable reagent for the selective mono- or didebenzylation in representative, multifunctionalized carbohydrate and amino acid derived N-dibenzylamines with neighboring O-functionality.
Grayson
Elizabeth J
EJ
Department of Chemistry, University of Oxford, Chemistry Research Laboratory, South Parks Road, Oxford OX1 3TA, UK.
Davis
Benjamin G
BG
D000596:Amino Acids / Q000737:chemistry*; D000605:Amino Alcohols / Q000737:chemistry*; D001555:Benzene Derivatives / Q000737:chemistry*; D002241:Carbohydrates / Q000737:chemistry*; D002625:Chemistry, Organic / Q000379:methods*; D015394:Molecular Structure; D013388:Succinimides / Q000737:chemistry*
D000596:Amino Acids; D000605:Amino Alcohols; D001555:Benzene Derivatives; D002241:Carbohydrates; D013388:Succinimides; C032620:succinimide