title: [31-year-old gravid woman of reversible posterior leukoencephalopathy syndrome associated with HELLP syndrome after labor].
abstract: We report on a 31-year-old gravid woman with reversible posterior leukoencephalopathy syndrome (RPLS) associated with HELLP syndrome. The patient was hospitalized and underwent an emergency cesarean section at the 34th week of pregnancy due to severe toxemia. After labor her blood pressure acutely increased to 180/100 mmHg and a generalized convulsion occurred. Laboratory data revealed hemolysis, elevated liver enzymes, and low platelets, consistent with HELLP syndrome. FLAIR and Apparent Diffusion Coefficient images on MRI showed hyperintense lesions bilaterally in the posterior white matter, however Diffusion-Weighted images revealed slightly hyperintense changes in the same locations. With the use of diltiazem for blood pressure control, and anticonvulsants, convulsions disappeared and consciousness level improved. Moreover the MRI abnormalities also improved after therapy. This case was diagnosed as RPLS associated with HELLP syndrome and is the first case of an investigation utilizing Diffusion-Weighted and Apparent Diffusion Coefficient images to establish this diagnosis. Based on these results, possible mechanisms of RPLS may be vasogenic edema mediated by a cerebrovascular endothelial disturbance of cerebral vessels and a rapid blood-pressure increase due to HELLP syndrome.
authors.affiliation: Department of Neurology, Yokohama Rosai Hospital.
authors.forename: Yu
authors.initials: Y
authors.lastname: Kono
authors.forename: Tomoki
authors.initials: T
authors.lastname: Nakamori
authors.forename: Ichiro
authors.initials: I
authors.lastname: Imafuku
authors.forename: Masanari
authors.initials: M
authors.lastname: Kunimoto
authors.forename: Miki
authors.initials: M
authors.lastname: Takei
authors.forename: Tokuo
authors.initials: T
authors.lastname: Kusaba
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D001929:Brain Edema / Q000150:complications / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D017359:HELLP Syndrome / Q000150:complications*; D006801:Humans; D020343:Hypertensive Encephalopathy / Q000150:complications* / Q000175:diagnosis; D049590:Postpartum Period; D011247:Pregnancy; D013577:Syndrome