Therapeutic capacity of the synthetic peptide-based vaccine against Taenia solium cysticercosis in pigs.
The S3Pvac synthetic vaccine composed of three peptides (GK1, KETc1 and KETc12) effectively protect against pig cysticercosis. Preliminary results point to an additional cysticidal capacity induced by S3Pvac or GK1 immunization. Herein, clear evidences of the cysticidal effect of S3Pvac but not of GK1 are presented. S3Pvac immunization of already experimentally infected pigs induced a reduction in the parasite load, in the vesicular cysticerci and in their viability. It also substantially increases the percent of histological damaged cysticerci more importantly in muscles than in brains, with a concomitant reduction in the antibody levels. Thus, S3Pvac represents a powerful means of controlling cysticercosis infection in pigs.
de Aluja
Aline S
AS
Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, 04510 México, DF, México. aline@servidor.unam.mx
Villalobos
Nelly M
NM
Nava
Gabriela
G
Toledo
Andrea
A
Martínez
José Juan
JJ
Plancarte
Agustín
A
Rodarte
Luis Felipe
LF
Fragoso
Gladis
G
Sciutto
Edda
E
D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D006224:Cricetinae; D003551:Cysticercosis / Q000473:pathology / Q000517:prevention & control / Q000662:veterinary*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008297:Male; D009132:Muscles / Q000469:parasitology; D013552:Swine; D013553:Swine Diseases / Q000517:prevention & control*; D041201:Taenia solium / Q000276:immunology*; D022223:Vaccines, Subunit / Q000008:administration & dosage / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000276:immunology
D000909:Antibodies, Helminth; D022223:Vaccines, Subunit; D014614:Vaccines, Synthetic