[Effects of Naoyaojia on structural mechanical properties of femur in rats].
OBJECTIVE
To study the effect of long term Naoyaojia administration on the structural mechanical properties of rat femurs.


METHODS
Young wistar rats were treated orally with Naoyaojia at doses of 3, 6, and 12 mg/kg body weight every 2 weeks for 1 year. Beary's bending test was used for determining physical properties of the femur.


RESULTS
The thickness of the cortex and cross-sectional area of femur increased significantly in animals treated with 3 mg/kg dose of Naoyaojia (P<0.01), significant increase in maximum bending load was also found in this group compared with the control group (P<0.01). But an opposite change was found in animals treated with 12 mg/kg dose of Naoyaojia.


CONCLUSIONS
Stimulation on the thickness of the cortex along the axis as well as the maximum bending load of femurs are found in animals treated with 3 mg/kg dose of Naoyaojia, but negative effects were observed at higher dose level.
Shi
Xiao-chun
XC
Institute of Space Medico-Engineering, Beijing, China.
Wu
Zeng-yan
ZY
Teng
Xi-he
XH
Wan
Yu-min
YM
D000818:Animals; D001696:Biomechanical Phenomena; D001846:Bone Development / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005269:Femur / Q000033:anatomy & histology / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal