title: Immunosuppressive sesquiterpenes from Tripterygium wilfordii.
abstract: Five new sesquiterpenes, 1beta-furanoyl-2beta,3alpha,7alpha,8beta,11-pentaacetoxy-4alpha,5alpha-dihydroxy-dihydroagarofuran (1), 1beta,2beta,3alpha,5alpha,7beta,8beta,11-heptaacetoxy-dihydroagarofuran (2), 1beta-furanoyl-2beta,3alpha,7alpha,8beta,11-pentaacetoxy-5alpha-hydroxy-dihydroagarofuran (3), 1beta,7beta,8alpha-triacetoxy-2beta-furanoyl-4alpha-hydroxy-11-isobutyryloxy-dihydroagarofuran (4), and 1beta-nicotinoyl-2beta,5alpha,7beta-triacetoxy-4alpha-hydroxy-11-isobutyryloxy-8alpha-furanoyl-dihydroagarofuran (5), were isolated from the xylem of Tripterygium wilfordii, together with a known compound (6). Their structures were elucidated on the basis of spectroscopic studies. Compounds 2-5 showed significant immunosuppressive activities.
authors.affiliation: The College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin 300072, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Wang
authors.forename: Wenyuan
authors.initials: W
authors.lastname: Gao
authors.forename: Zhi
authors.initials: Z
authors.lastname: Yao
authors.forename: Shaoyu
authors.initials: S
authors.lastname: Zhang
authors.forename: Yanwen
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Takaishi
authors.forename: Hongquan
authors.initials: H
authors.lastname: Duan
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D027343:Rhizome; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D029757:Tripterygium
chemical_list: D004365:Drugs, Chinese Herbal; D007166:Immunosuppressive Agents; D012717:Sesquiterpenes