[Peritoneal dialysis with allogenic hepatic cell suspension in treatment of hepatic insufficiency].
Increasing prevalence of patients with liver diseases results in growth of morbidity caused by liver insufficiency. The comparative analysis of the different methods (hemosorption, hemofiltration, plasmapheresis, liver cell transplantation) for the treatment of the hepatic failure showed that the mortality rate of such patients remains to be high. Ex vivo blood treatment can be divided into three categories: passive detoxification, liver perfusion and bioartificial or cell-based systems. A cellular dialyzing fluid was used in rats to evaluate efficacy of peritoneal dialysis in the treatment of hepatic insufficiency. The results of treatment of animals suffering from acute toxic disease of the liver indicate to the high therapeutic effectiveness of such dialysis. Cellular peritoneal dialysis did not induce anaphylactic reactions in animals. Favorable dynamics of changes in the biochemical, clinical and morphological induces were noted, which allows this method to be recommended for clinical approbation.
Kardava
I
I
Tbilisi State Medical Academy, Department of Clinical Anatomy, Georgia.
Chutkerashvili
K
K
D000208:Acute Disease; D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D017690:Cell Transplantation; D004195:Disease Models, Animal; D005260:Female; D048550:Hepatic Insufficiency / Q000139:chemically induced / Q000473:pathology / Q000628:therapy*; D022781:Hepatocytes / Q000637:transplantation*; D008099:Liver / Q000166:cytology*; D008297:Male; D010530:Peritoneal Dialysis / Q000379:methods*; D051381:Rats; D014182:Transplantation, Autologous; D016896:Treatment Outcome
D002251:Carbon Tetrachloride