title: Voltammetric determination of montelukast sodium in dosage forms and human plasma.
abstract: The voltammetric behaviour of montelukast (MKST) was studied using cyclic voltammetry, direct current (DCt), differential pulse polarography (DPP) and alternating current (ACt) polarography. MKST exhibited well-defined cathodic waves over the range pH range 1-5. No anodic waves were produced over the same pH range. At pH 1, the analytical pH; the diffusion current constant (Id) was 2.2+/-0.01 microA l mmol-1. The current concentration plot was rectilinear over the range 2-20 microg ml-1 with correlation coefficient (n=10) of 0.9943. The lower limit of detection (S/N=2) was 0.2 microg ml-1 (3.41x10(-7) M). The wave has been characterised as being diffusion-controlled, although adsorption phenomenon played a limited role in the electrode reaction. The proposed method was successfully applied to the determination of MKST in commercial tablets, and results were in agreement with those given with a reference HPLC method. The method was further extended to the in vitro determination of the drug in spiked human plasma. The mean % recovery (n=5) was 101.38+/-3.85. The number of electrons transferred in the reduction process could be accomplished and a proposal of the electrode reaction was proposed.
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
authors.forename: I
authors.initials: I
authors.lastname: Alsarra
authors.forename: M
authors.initials: M
authors.lastname: Al-Omar
authors.forename: E A
authors.initials: EA
authors.lastname: Gadkariem
authors.forename: F
authors.initials: F
authors.lastname: Belal
mesh_terms: D000085:Acetates / Q000097:blood* / Q000737:chemistry; D000465:Algorithms; D002138:Calibration; D003521:Cyclopropanes; D006801:Humans; D015394:Molecular Structure; D011048:Polarography / Q000295:instrumentation / Q000379:methods*; D011804:Quinolines / Q000097:blood* / Q000737:chemistry; D015203:Reproducibility of Results; D013440:Sulfides; D013607:Tablets
chemical_list: D000085:Acetates; D003521:Cyclopropanes; D011804:Quinolines; D013440:Sulfides; D013607:Tablets; C093875:montelukast