title: Concomitant Ewing sarcoma and acute lymphoblastic leukemia in a 5-year-old girl.
abstract: Malignancies from the Ewing family of tumors and acute lymphoblastic leukemia (ALL) are not known to be associated with each other. A 5-year-old girl was incidentally found to suffer from acute lymphoblastic leukemia during bone marrow staging for Ewing sarcoma of the radius. The simultaneous presence of two distinct neoplasms was confirmed by RT-PCR, with EWS/FLI1 type 1 rearrangement in the bone tumor and TEL/AML1 rearrangement in the marrow. She was treated with chemotherapy, radiotherapy, and surgery and was in remission of both diseases 31 months after diagnosis.
authors.affiliation: Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany.
authors.forename: Katja
authors.initials: K
authors.lastname: Masjosthusmann
authors.forename: Stefan S
authors.initials: SS
authors.lastname: Bielack
authors.forename: Gabriele
authors.initials: G
authors.lastname: Köhler
authors.forename: Annekathrein
authors.initials: A
authors.lastname: Florax
authors.forename: Manfred
authors.initials: M
authors.lastname: Schiborr
authors.forename: Jochen
authors.initials: J
authors.lastname: Bruch
authors.forename: Dirk
authors.initials: D
authors.lastname: Reinhardt
authors.forename: Nanna
authors.initials: N
authors.lastname: Kuhn
authors.forename: Michael
authors.initials: M
authors.lastname: Paulussen
authors.forename: Herbert
authors.initials: H
authors.lastname: Jürgens
mesh_terms: D002675:Child, Preschool; D003131:Combined Modality Therapy; D050676:Core Binding Factor Alpha 2 Subunit; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015514:Oncogene Proteins, Fusion; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D051789:Proto-Oncogene Protein c-fli-1; D034802:RNA-Binding Protein EWS; D012512:Sarcoma, Ewing / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D014178:Translocation, Genetic; D000097764:ETS Translocation Variant 6 Protein
chemical_list: D050676:Core Binding Factor Alpha 2 Subunit; D015514:Oncogene Proteins, Fusion; D051789:Proto-Oncogene Protein c-fli-1; D034802:RNA-Binding Protein EWS; C106031:EWS-FLI fusion protein; C102421:TEL-AML1 fusion protein; D000097764:ETS Translocation Variant 6 Protein