title: Screening for Down syndrome based on maternal age or fetal nuchal translucency: a randomized controlled trial in 39,572 pregnancies.
abstract: OBJECTIVE
  Nuchal translucency (NT) screening increases antenatal detection of Down syndrome (DS) compared to maternal age-based screening. We wanted to determine if a change in policy for prenatal diagnosis would result in fewer babies born with DS.
  
  
  METHODS
  A total of 39,572 pregnant women were randomized to a scan at 12-14 gestational weeks including NT screening for DS (12-week group) or to a scan at 15-20 weeks with screening for DS based on maternal age (18-week group). Fetal karyotyping was offered if risk according to NT was > or = 1:250 in the 12-week group and if maternal age was > or = 35 years in the 18-week group. Both policies included the offer of karyotyping in cases of fetal anomaly detected at any scan during pregnancy or when there was a history of fetal chromosomal anomaly. The number of babies born with DS and the number of invasive tests for fetal karyotyping were compared.
  
  
  RESULTS
  Ten babies with DS were born alive with the 12-week policy vs. 16 with the 18-week policy (P = 0.25). More fetuses with DS were spontaneously lost or terminated in the 12-week group (45/19,796) than in the 18-week group (27/19 776; P = 0.04). All women except one with an antenatal diagnosis of DS at < 22 weeks terminated the pregnancy. For each case of DS detected at < 22 weeks in a living fetus there were 16 invasive tests in the 12-week group vs. 89 in the 18-week group. NT screening detected 71% of cases of DS for a 3.5% test-positive rate whereas maternal age had the potential of detecting 58% for a test-positive rate of 18%.
  
  
  CONCLUSIONS
  The number of newborns with DS differed less than expected between pregnancies that had been screened at 12-14 weeks' gestation by NT compared with those screened at 15-20 weeks by maternal age. One explanation could be that NT screening--because it is performed early in pregnancy--results in the detection and termination of many pregnancies with a fetus with DS that would have resulted in miscarriage without intervention, and also by many cases of DS being detected because of a fetal anomaly seen on an 18-week scan. The major advantage of the 12-week scan policy is that many fewer invasive tests for fetal karyotyping are needed per antenatally detected case of DS.
authors.affiliation: Department of Obstetrics and Gynecology, South Stockholm General Hospital, Stockholm, Sweden. sissel.saltvedt@kids.ki.se
authors.forename: S
authors.initials: S
authors.lastname: Saltvedt
authors.forename: H
authors.initials: H
authors.lastname: Almström
authors.forename: M
authors.initials: M
authors.lastname: Kublickas
authors.forename: L
authors.initials: L
authors.lastname: Valentin
authors.forename: R
authors.initials: R
authors.lastname: Bottinga
authors.forename: T-H
authors.initials: TH
authors.lastname: Bui
authors.forename: M
authors.initials: M
authors.lastname: Cederholm
authors.forename: P
authors.initials: P
authors.lastname: Conner
authors.forename: B
authors.initials: B
authors.lastname: Dannberg
authors.forename: P
authors.initials: P
authors.lastname: Malcus
authors.forename: A
authors.initials: A
authors.lastname: Marsk
authors.forename: C
authors.initials: C
authors.lastname: Grunewald
mesh_terms: D000328:Adult; D004314:Down Syndrome / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007621:Karyotyping; D008403:Mass Screening / Q000379:methods; D008423:Maternal Age; D048208:Nuchal Translucency Measurement / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome