Catalytic enantioselective fluorination and amination of beta-keto phosphonates catalyzed by chiral palladium complexes.
[reaction: see text] The catalytic enantioselective fluorination and amination of beta-keto phosphonates catalyzed by chiral palladium complexes is described. Treatment of beta-keto phosphonates with N-fluorobenzenesulfonimide (NFSI) as electrophilic fluorinating reagent and diethyl azodicarboxylate (DEAD) as electrophilic amination reagent under mild reaction conditions afforded the corresponding alpha-substituted beta-keto phosphonates in moderate to excellent yields with excellent enantiomeric excesses.
Kim
Sung Min
SM
Department of Chemistry, Division of Applied Science, Soonchunhyang University, 644 Eupnae-ri, Shinchang, Asan, Chungnam 336-745, Korea.
Kim
Hye Ran
HR
Kim
Dae Young
DY