Probing secondary carbohydrate-protein interactions with highly dense cyclodextrin-centered heteroglycoclusters: the heterocluster effect.
Comparison of the lectin-binding properties for highly dense beta-cyclodextrin-centered homo- and heteroglycoclusters with defined architecture provides evidence for the existence of strong synergic effects (heterocluster effect) on carbohydrate-protein recognition events.
Gómez-García
Marta
M
Instituto de Investigaciones Químicas, CSIC, Américo Vespucio 49, Isla de la Cartuja, E-41092 Sevilla, Spain.
Benito
Juan M
JM
Rodríguez-Lucena
David
D
Yu
Jian-Xin
JX
Chmurski
Kazimierz
K
Ortiz Mellet
Carmen
C
Gutiérrez Gallego
Ricardo
R
Maestre
Alfredo
A
Defaye
Jacques
J
García Fernández
José M
JM
D002236:Carbohydrate Conformation; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000737:chemistry*; D003208:Concanavalin A / Q000737:chemistry / Q000378:metabolism; D005947:Glucose / Q000737:chemistry / Q000378:metabolism; D007785:Lactose / Q000737:chemistry / Q000378:metabolism; D008358:Mannose / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D013816:Thermodynamics; D047392:beta-Cyclodextrins / Q000737:chemistry* / Q000378:metabolism
D002241:Carbohydrates; D047392:beta-Cyclodextrins; D003208:Concanavalin A; D005947:Glucose; D007785:Lactose; C031215:betadex; D008358:Mannose