title: [Effects of 2450 MHz microwave on long-term potentiation of hippocampus and lipofuscin contents in rat brain].
abstract: OBJECTIVE
  To study the mechanism of the effects of microwave on learning and memory.
  
  
  METHODS
  Long-term potentiation (LTP) of hippocampus induced potential and lipofuscin content in rat brain were studied. After irradiated by a 2450 MHz microwave, rats hippocampus induced potential in vivo was recorded and lipofuscin content in the brain was measured by fluorospectrophotometry.
  
  
  RESULTS
  Continuous microwave with 10-25 mW/cm2 intensity could inhibit the amplitude of the population spike (PS) of weak and strong stimuli induced LTP with an intensity-effect relationship. At 25 mW/cm2, lipofuscin content was significantly higher than control and 10 mW/cm2 group (P<0.05).
  
  
  CONCLUSIONS
  Continuous microwave with 10-25 mW/cm2 intensity impairs learning and memory by restraining hippocampus LTP and brain lipofuscin content.
authors.affiliation: Institute of Space Medico-Engineering, Beijing, China.
authors.forename: Ya-li
authors.initials: YL
authors.lastname: Zhao
authors.forename: Xiao-dong
authors.initials: XD
authors.lastname: Peng
authors.forename: Yu-hua
authors.initials: YH
authors.lastname: Yang
authors.forename: Hong-bo
authors.initials: HB
authors.lastname: Ma
authors.forename: Jin-ping
authors.initials: JP
authors.lastname: Song
authors.forename: Jing-sui
authors.initials: JS
authors.lastname: Pu
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D006624:Hippocampus / Q000502:physiology* / Q000528:radiation effects*; D007858:Learning / Q000528:radiation effects; D008062:Lipofuscin / Q000378:metabolism / Q000528:radiation effects*; D017774:Long-Term Potentiation / Q000502:physiology / Q000528:radiation effects*; D008568:Memory / Q000528:radiation effects; D008872:Microwaves; D051381:Rats; D017208:Rats, Wistar
chemical_list: D008062:Lipofuscin