title: Hardy-Weinberg testing of a single homozygous genotype.
abstract: No proper statistical test is available for the evaluation of deviation of a single homozygous genotype from Hardy-Weinberg equilibrium (HWE) proportion. We propose a 1-d.f. chi2-test. The power of the proposed test is favorable compared to existing HWE testing procedures. The applications of this test are discussed.
authors.affiliation: Department of Preventive Medicine, State University of New York, Stony Brook, New York 11794, USA. john.chen@stonybrook.edu
authors.forename: John J
authors.initials: JJ
authors.lastname: Chen
authors.forename: Tao
authors.initials: T
authors.lastname: Duan
authors.forename: Richard
authors.initials: R
authors.lastname: Single
authors.forename: Kristie
authors.initials: K
authors.lastname: Mather
authors.forename: Glenys
authors.initials: G
authors.lastname: Thomson
mesh_terms: D005787:Gene Frequency; D005828:Genetics, Population; D005838:Genotype; D008957:Models, Genetic; D013223:Statistics as Topic / Q000379:methods*