Matrix metalloproteinase-1 expression inhibitory compound from the whole plants of Viola ibukiana Makino.
Bioassay-guided fractionation has led to the isolation of two triterpenoid saponins 3-O-[O-beta-D-glucopyranosyl-(1 --> 3)-O-beta-D-glucopyranosyl] oleanolic acid (1), and 3-O-[O-beta-D-glucopyranosyl-(1 --> 2)-O-beta-D-glucopyranosyl] oleanolic acid (2) from the whole plants of Viola ibukiana Makino. Compound 2 showed matrix metalloproteinase-1 expression inhibition activities in a dose-dependent manner.
Moon
Hyung-In
HI
Department of Dermatology, Seoul National University College of Medicine and Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, Seoul, 110-744, Korea.
Kim
Mi-Ran
MR
Cho
Moon Kyun
MK
Park
Soojie
S
Chung
Jin-Ho
JH
D015153:Blotting, Western; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D006801:Humans; D007641:Keratolytic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D020781:Matrix Metalloproteinase 1 / Q000096:biosynthesis*; D061965:Matrix Metalloproteinase Inhibitors; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012867:Skin / Q000166:cytology; D014466:Ultraviolet Rays; D032413:Viola
D007641:Keratolytic Agents; D061965:Matrix Metalloproteinase Inhibitors; D010936:Plant Extracts; D020781:Matrix Metalloproteinase 1