[Role of PAI-1 in gynaecological malignancies].
The plasminogen activator-plasmin cascade plays a central role in tumor cell invasion and metastasis of solid tumors. The type-1 plasminogen activator inhibitor (PAI-1) is the major physiologic regulator of the plasminogen activation. The PAI-1 is suggested to play a crucial role in tumor cell invasion and metastasis of different solid tumors. The aim of this article is to give an overview of the function, clinical and prognostic role of PAI-1 in gynaecological malignancies.
Könsgen
D
D
Klinik für Frauenheilkunde und Geburtshilfe, Campus Virchow-Klinikum, Charité Universitätsmedizin Berlin.
Mustea
A
A
Lichtenegger
W
W
Sehouli
J
J
D005260:Female; D005833:Genital Neoplasms, Female / Q000473:pathology*; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D017395:Plasminogen Activator Inhibitor 1 / Q000502:physiology*; D011379:Prognosis
D017395:Plasminogen Activator Inhibitor 1