title: Caspofungin in combination with amphotericin B against Candida glabrata.
abstract: The effects of caspofungin combined with amphotericin B were investigated with Candida glabrata. Although in vitro experiments showed an indifferent interaction, the combination regimen was the only therapeutic approach yielding organ sterilization in a murine candidemia model.
authors.affiliation: Istituto di Malattie Infettive e Medicina Pubblica, Università Politecnica delle Marche, Azienda Ospedaliera-Universitaria, Ospedali Riuniti, Umberto I-G.M. Lancisi-G. Salesi, Ancona, Italy. l.infettive@ao-umbertoprimo.marche.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Barchiesi
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Spreghini
authors.forename: Annette W
authors.initials: AW
authors.lastname: Fothergill
authors.forename: Daniela
authors.initials: D
authors.lastname: Arzeni
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Greganti
authors.forename: Daniele
authors.initials: D
authors.lastname: Giannini
authors.forename: Michael G
authors.initials: MG
authors.lastname: Rinaldi
authors.forename: Giorgio
authors.initials: G
authors.lastname: Scalise
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D041221:Candida glabrata / Q000187:drug effects* / Q000254:growth & development; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology; D000077336:Caspofungin; D015169:Colony Count, Microbial; D004359:Drug Therapy, Combination; D054714:Echinocandins; D016469:Fungemia / Q000188:drug therapy* / Q000382:microbiology; D055666:Lipopeptides; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests / Q000379:methods; D010456:Peptides, Cyclic / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; D000666:Amphotericin B; D000077336:Caspofungin