title: [Comparison between the distraction and grafting methods in the treatment of peripheral neural defects: an experimental study in rabbits].
abstract: OBJECTIVE
  We compared the electrophysiologic and histopathologic results of grafting and distraction methods in the treatment of defective peripheral neural injuries.
  
  
  METHODS
  Thirty male white rabbits (age 6 months) were divided into three groups and a circular external fixator (CEF) was applied to the right tibias. In group I (primary repair), the right deep peroneal nerve was cut without inducing any defect and a tibial osteotomy was performed. The remaining groups underwent bone and nerve excision of about 1 cm in the middle third of the tibia. In group II, the defect area was closed acutely with the CEF and the continuity of the nerve was restored. In group III, a nerve graft obtained from the left side was placed in the defect area and an epiperineural repair was made. Group II underwent distraction 21 days after surgery for 10 days with a rate of 0.25 mm four times a day. Electrophysiological studies were performed in the 12th and 24th weeks and nerve biopsies were obtained in the 32nd week for histopathologic examination.
  
  
  RESULTS
  Electrophysiological studies in the 12th week did not show any significant differences in nerve conduction between the three groups; however, in the 24th week, amplitude and latency values of the graft group were 50% lower than those of the primary repair and distraction groups (p<0.05). On histological examination, the results were good in group I and II, but poor in group III with respect to nerve fiber density, thickness of the myelin sheath, degenerative changes in the myelin sheath, and average axon number.
  
  
  CONCLUSIONS
  Our data demonstrate that treatment of neural defects by the distraction method results in much better results than the grafting method.
authors.affiliation: Department of Orthopedics and Traumatology (Ortopedi ve Travmatoloji Anabilim Dali), Gülhane Military School of Medicine, Ankara, Turkey. mkurklu@hotmail.com
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kürklü
authors.forename: Bahtiyar
authors.initials: B
authors.lastname: Demiralp
authors.forename: Vecihi
authors.initials: V
authors.lastname: Kirdemir
authors.forename: Mahmut
authors.initials: M
authors.lastname: Kömürcü
authors.forename: Umit Hidir
authors.initials: UH
authors.lastname: Ulaş
authors.forename: Emin
authors.initials: E
authors.lastname: Oztaş
authors.forename: A Sabri
authors.initials: AS
authors.lastname: Ateşalp
authors.forename: Mustafa
authors.initials: M
authors.lastname: Başbozkurt
mesh_terms: D000818:Animals; D001852:Bone Lengthening; D016267:External Fixators; D008297:Male; D009408:Nerve Compression Syndromes / Q000473:pathology / Q000601:surgery*; D019635:Neurosurgical Procedures; D010525:Peripheral Nerves / Q000473:pathology / Q000601:surgery*; D011817:Rabbits; D013977:Tibia / Q000601:surgery*