Expression of IL-31 gene transcripts in NC/Nga mice with atopic dermatitis.
To search for the pruritogen of atopic dermatitis, a characteristic symptom in atopic dermatitis patients, we examined interleukin-31 (IL-31) mRNA expression in NC/Nga mice as an animal model of atopic dermatitis. The expression of IL-31 mRNA in the skin of NC/Nga mice with scratching behavior was significantly higher than that in NC/Nga mice without scratching behavior. Our findings suggest that IL-31 may participate in the cause of itch sensation and promote scratching behavior in NC/Nga mice with atopic dermatitis.
Takaoka
Akiko
A
Department of Medicinal Pharmacology, Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan. a.takaoka@po.rd.taisho.co.jp
Arai
Iwao
I
Sugimoto
Masanori
M
Yamaguchi
Akie
A
Tanaka
Makoto
M
Nakaike
Shiro
S
D000818:Animals; D003876:Dermatitis, Atopic / Q000235:genetics*; D015870:Gene Expression / Q000235:genetics*; D007378:Interleukins / Q000235:genetics*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011537:Pruritus / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012867:Skin / Q000378:metabolism / Q000473:pathology; D013047:Specific Pathogen-Free Organisms; D014158:Transcription, Genetic / Q000235:genetics
D007378:Interleukins; D012333:RNA, Messenger; C502588:interleukin-31, mouse