[Molecular-cellular effects of insulin and possible mechanisms of insulin resistance development in patients with ischemic heart disease (CAD)].
The data of modern experimental study of insulin receptors structure characteristics, the hormone effects on receptor and postreceptor molecular-cellular level, the ways hormone signal in cardiomiocites (CMC) as well as intercoupling possibility with other mediators and hormones from the point of view of probable mechanisms of hyperinsulinemia are analysed in the survey. On the basis of personal studies clinical conditions at which hyperinsulinemia manifests in patients with CAD are described. Conception is offered in accordance with which one of the reasons of "insulineresistance" at CAD can be a significant energetic CMC potential decrease as a result of myocardial metabolism remodeling in conditions of prolonged chronic ischemia, which forestalls significantly clinical manifestation of the disease.
Telkova
I L
IL
Research institute of Cardiology Tomsk scientific centre SD RAMS, Tomsk.
D000818:Animals; D005947:Glucose / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000378:metabolism; D006946:Hyperinsulinism / Q000209:etiology / Q000503:physiopathology; D007328:Insulin / Q000502:physiology*; D007333:Insulin Resistance / Q000502:physiology*; D017202:Myocardial Ischemia / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D032383:Myocytes, Cardiac / Q000378:metabolism; D011972:Receptor, Insulin / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction
D007328:Insulin; D011972:Receptor, Insulin; D005947:Glucose