Identification of antitumor activity of pyrazole oxime ethers.
A series of pyrazole oxime ether derivatives were prepared and examined as cytotoxic agents. In particular, 5-phenoxypyrazole was comparable to doxorubicin, while exhibiting very potent cytotoxicity against XF 498 and HCT15.
Park
Hyun-Ja
HJ
Bio-Organic Science Division, Korea Research Institute of Chemical Technology, PO Box 107, Yusong, Taejon 305-600, Republic of Korea.
Lee
Kyung
K
Park
Su-Jin
SJ
Ahn
Bangle
B
Lee
Jong-Cheol
JC
Cho
Heeyeong
H
Lee
Kee-In
KI
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004987:Ethers; D006801:Humans; D020128:Inhibitory Concentration 50; D010091:Oximes; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D004987:Ethers; D010091:Oximes; D011720:Pyrazoles