The herpes simplex virus ICP27 protein: a multifunctional post-transcriptional regulator of gene expression.
The herpes simplex virus 1 ICP27 is an essential, highly conserved protein involved in various steps of herpes simplex virus 1 gene regulation as well as in the shut-off of host gene expression during infection. It functions primarily at the post-transcriptional level in inhibiting precursor mRNA splicing and in promoting nuclear export of viral transcripts. These activities are discussed.
Smith
R W P
RW
Division of Virology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G11 5JR, Scotland, UK.
Malik
P
P
Clements
J B
JB
D000818:Animals; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D017874:Immediate-Early Proteins / Q000737:chemistry / Q000378:metabolism*; D021381:Protein Transport; D012326:RNA Splicing / Q000235:genetics; D034443:RNA Transport; D014158:Transcription, Genetic / Q000235:genetics
C057120:ICP27 protein, human herpesvirus 1; D017874:Immediate-Early Proteins