title: Topographically induced direct cell mechanotransduction.
abstract: This review is designed to introduce the cytoskeleton and then discuss how mechanical forces may be transduced to the cell nucleus. In addition to this, it also tries to explain current thinking as to how the nucleus turns these mechanical cues into gene changes and is especially interested in mechanotransduction arising from topographically induced morphological changes, specifically nanotopography. Thus, this review also describes cell responses to topography.
authors.affiliation: Centre for Cell Engineering, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK. m.dalby@bio.gla.ac.uk
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Dalby
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D002467:Cell Nucleus / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D008954:Models, Biological