title: Synthesis and antibacterial activity of novel (un)substituted benzotriazolyl oxazolidinone derivatives.
abstract: A series of novel (un)substituted benzotriazolyl oxazolidinone derivatives has been synthesized and tested for in vitro antibacterial activities by MIC determination against a panel of susceptible and resistant Gram-positive and Gram-negative microorganisms, some of which are resistant to methicillin and vancomycin. Compounds 20, 21, 24, 29 and 30 from this series were found to be equipotent or more potent than linezolid in vitro.
authors.affiliation: Medicinal Chemistry Division, New Chemical Entity Research, Lupin Research Park, 46/47A, Village Nande, Taluka Mulshi, Pune 411 042, Maharashtra, India.
authors.forename: Prasad P
authors.initials: PP
authors.lastname: Dixit
authors.forename: Prathap S
authors.initials: PS
authors.lastname: Nair
authors.forename: Vijaykumar J
authors.initials: VJ
authors.lastname: Patil
authors.forename: Sanjay
authors.initials: S
authors.lastname: Jain
authors.forename: Sudershan K
authors.initials: SK
authors.lastname: Arora
authors.forename: Neelima
authors.initials: N
authors.lastname: Sinha
mesh_terms: D000081:Acetamides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D066298:In Vitro Techniques; D000069349:Linezolid; D008712:Methicillin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D023303:Oxazolidinones / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D010080:Oxazoles; D023303:Oxazolidinones; D014640:Vancomycin; D000069349:Linezolid; D008712:Methicillin