title: Safety of one-stage restorative proctocolectomy for ulcerative colitis.
abstract: OBJECTIVE
  The aim of this study was to compare clinical outcomes in patients with ulcerative colitis who underwent restorative proctocolectomy with and without diverting ileostomy.
  
  
  METHODS
  A series of 245 consecutive patients who underwent ileal pouch anal anastomosis with mucosectomy with an ultrasonically activated scalpel (harmonic scalpel) was studied. Of these patients, 92 patients had a diverting ileostomy and 150 selected patients did not. The decision for or against an ileostomy was made at the end of the operation.
  
  
  RESULTS
  Twelve patients (8 percent) in the group without ileostomy had pouch-related complications, which necessitated secondary ileostomy in five patients (3.3 percent). Intestinal obstruction developed in 17 patients (11.3 percent) who had no ileostomy and in 12 patients (13.0 percent) who underwent ileostomy. Two of 17 patients who had no ileostomy and 1 of 12 patients with ileostomy required laparotomy with division of adhesions, whereas the remaining patients responded to conservative measures. There were no significant differences in the incidence of postoperative complications after the initial operation between the two groups. In the group with ileostomy, the morbidity rate for ileostomy was 12.1 percent, and that for ileostomy closure was 18.7 percent. The total postoperative complication rate for the group with ileostomy was significant higher than that for the group without ileostomy.
  
  
  CONCLUSIONS
  We conclude that restorative proctocolectomy with mucosectomy by use of an ultrasonically activated scalpel and without diversion is a superior therapeutic choice for selected patients.
authors.affiliation: Second Department of Surgery, Hyogo College of Medicine, Hyogo, Japan. ikeuci2s@hyo-med.ac.jp
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ikeuchi
authors.forename: Hiroki
authors.initials: H
authors.lastname: Nakano
authors.forename: Motoi
authors.initials: M
authors.lastname: Uchino
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Nakamura
authors.forename: Masafumi
authors.initials: M
authors.lastname: Noda
authors.forename: Hidenori
authors.initials: H
authors.lastname: Yanagi
authors.forename: Takehira
authors.initials: T
authors.lastname: Yamamura
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000714:Anastomosis, Surgical; D003093:Colitis, Ulcerative / Q000601:surgery*; D039021:Colonic Pouches; D005260:Female; D006801:Humans; D007081:Ileostomy / Q000009:adverse effects; D007413:Intestinal Mucosa / Q000601:surgery; D007415:Intestinal Obstruction / Q000209:etiology; D007813:Laparotomy; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D016737:Proctocolectomy, Restorative; D012086:Reoperation; D012449:Safety; D013530:Surgical Wound Infection / Q000209:etiology; D000267:Tissue Adhesions / Q000209:etiology; D016896:Treatment Outcome; D014464:Ultrasonic Therapy / Q000295:instrumentation