Chronic hyperprolinemia provokes a memory deficit in the Morris water maze task.
In the present study we investigated the effect of chronic proline (Pro) administration on rat performance in the Morris water maze task. Rats received s.c. injections of Pro twice a day at 8 h intervals from the 6th to the 28th days of age and equivalent volume of 0.9% saline solution (control). On the 60th day of life, rats were subjected to the water maze task. Results showed that chronic Pro administration provokes impairment on spatial learning, as shown by the increase of latency in acquisition and retention and by a reduced efficiency to find the platform position in the working memory test. Present results suggest that hyperprolininemia causes cognitive dysfunction and might be relevant to explain, at least in part, the neurological dysfunction associated with hyperprolinemia.
Bavaresco
Caren Serra
CS
Department of Biochemistry, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Streck
Emilio Luíz
EL
Netto
Carlos Alexandre
CA
Wyse
Angela Terezinha de Souza
AT
D000592:Amino Acid Metabolism, Inborn Errors / Q000378:metabolism / Q000503:physiopathology*; D000818:Animals; D020739:Brain Diseases, Metabolic, Inborn / Q000378:metabolism / Q000503:physiopathology*; D002908:Chronic Disease; D004195:Disease Models, Animal; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology*; D008569:Memory Disorders / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*; D008570:Memory, Short-Term / Q000187:drug effects / Q000502:physiology; D011392:Proline / Q000008:administration & dosage / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology
D011392:Proline