New insight into the pathophysiology of severe hypothyroidism in an infant with multiple hepatic hemangiomas.
We report on an infant with severe acquired hypothyroidism resulting from both increased activity of type 3 iodothyronine deiodinase and increased production of TSH-like hormone from hepatic hemangiomas. The combination of these two mechanisms in a patient with hepatic hemangiomas has not been reported previously.
Ho
Josephine
J
Department of Pediatrics, Alberta Children's Hospital, Calgary, Alberta, Canada.
Kendrick
Victoria
V
Dewey
Deborah
D
Pacaud
Danièle
D
D005260:Female; D006391:Hemangioma / Q000150:complications*; D006801:Humans; D007037:Hypothyroidism / Q000209:etiology* / Q000503:physiopathology*; D007223:Infant; D007231:Infant, Newborn; D008113:Liver Neoplasms / Q000150:complications*; D012720:Severity of Illness Index; D014284:Triiodothyronine / Q000378:metabolism
D014284:Triiodothyronine