Protective effect of a 50% hydroalcoholic fruit extract of Emblica officinalis against anti-tuberculosis drugs induced liver toxicity.
The present report showed the hepatoprotective property of a 50% hydroalcoholic extract of the fruits of Emblica officinalis (fruit) (EO-50) against antituberculosis (anti-TB) drugs-induced hepatic injury. The biochemical manifestations of hepatotoxicity induced by rifampicin (RIF), isoniazid (INH) and pyrazinamide (PZA), either given alone or in combination were evaluated. In vitro studies were done on suspension cultures of rat hepatocytes while sub-acute studies were carried out in rats. The hepatoprotective activity of EO-50 was found to be due to its membrane stabilizing, antioxidative and CYP 2E1 inhibitory effects.
Tasduq
S A
SA
Division of Pharmacology, Regional Research Laboratory, Jammu-Tawi 180001 India.
Kaisar
P
P
Gupta
D K
DK
Kapahi
B K
BK
Maheshwari
H S
HS
Jyotsna
S
S
Johri
R K
RK
D000818:Animals; D000995:Antitubercular Agents / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D005638:Fruit; D022781:Hepatocytes / Q000187:drug effects; D006801:Humans; D007538:Isoniazid / Q000633:toxicity; D008297:Male; D029842:Phyllanthus emblica; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D020011:Protective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011718:Pyrazinamide / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D012293:Rifampin / Q000633:toxicity; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy
D000995:Antitubercular Agents; D010936:Plant Extracts; D020011:Protective Agents; D011718:Pyrazinamide; D007538:Isoniazid; D012293:Rifampin