title: Evaluation of serum sandwich enzyme-linked immunosorbent assay for circulating galactomannan during caspofungin therapy: results from the caspofungin invasive aspergillosis study.
abstract: There has been minimal clinical experience with the use of the Aspergillus galactomannan enzyme-linked immunosorbent assay (ELISA) for patients receiving echinocandin therapy. We reviewed the experience with the galactomannan ELISA for 17 patients in a study of caspofungin treatment for invasive aspergillosis. The rate of successful outcomes for these patients was similar to that overall for participants in the study. Trends in antigenemia levels correlated with clinical and radiographic findings.
authors.affiliation: University Hospital Gasthuisberg, Leuven, Belgium.
authors.forename: Johan
authors.initials: J
authors.lastname: Maertens
authors.forename: Axel
authors.initials: A
authors.lastname: Glasmacher
authors.forename: Dominik
authors.initials: D
authors.lastname: Selleslag
authors.forename: Angela
authors.initials: A
authors.lastname: Ngai
authors.forename: Desmond
authors.initials: D
authors.lastname: Ryan
authors.forename: Melissa
authors.initials: M
authors.lastname: Layton
authors.forename: Arlene
authors.initials: A
authors.lastname: Taylor
authors.forename: Carole
authors.initials: C
authors.lastname: Sable
authors.forename: Nicholas
authors.initials: N
authors.lastname: Kartsonis
mesh_terms: D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D000946:Antigens, Fungal / Q000097:blood*; D001228:Aspergillosis / Q000188:drug therapy* / Q000382:microbiology; D000077336:Caspofungin; D054714:Echinocandins; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005690:Galactose / Q000031:analogs & derivatives; D006801:Humans; D055666:Lipopeptides; D008172:Lung Diseases, Fungal / Q000188:drug therapy* / Q000382:microbiology; D008351:Mannans / Q000097:blood*; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D000946:Antigens, Fungal; D054714:Echinocandins; D055666:Lipopeptides; D008351:Mannans; D010456:Peptides, Cyclic; C012990:galactomannan; D000077336:Caspofungin; D005690:Galactose