Donor CD31 genotype and its association with acute graft-versus-host disease in HLA identical sibling stem cell transplantation.
CD31 gene polymorphisms are implicated in the pathogenesis of graft-versus-host disease (GvHD) following haematopoietic stem cell transplantation (HST). We investigated the influence of CD31 genotype on the incidence of GvHD following HST from an human leukocyte antigen (HLA)-identical sibling donor. Donor and recipient CD31 codons 125, 563 and 670 DNA polymorphisms were determined in 85 cases of HLA identical sibling HST from two transplant centres. A correlation between CD31 genotype and acute GvHD was considered significant if observed in patients from both transplant centres independently. A strong correlation was identified between donor CD31 codon 125 genotype and the incidence of acute GvHD. Acute GvHD grades II-IV occurred in 27 of 46 (59%) recipients with a CD31 codon 125 leucine / valine heterozygous donor compared to nine of 39 (23%) recipients with a CD31 codon 125 homozygous donor (P=0.0019, relative-risk 2.45, 95% confidence interval 1.3-4.5). This correlation was significant in patients from both transplant centres (P=0.015 and P=0.019). We suggest that CD31 genotype may influence the function of donor-derived leukocytes and may be informative when there is a choice of comparable donors.
Goodman
R S
RS
Tissue Typing Laboratory, Addenbrooke's Cambridge University Teaching Hospital Trust, Cambridge, UK. reyna.goodman@addenbrookes.nhs.uk
Ewing
J
J
Evans
P C
PC
Craig
J
J
Poulton
K
K
Dyer
P A
PA
Marcus
R E
RE
Taylor
C J
CJ
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D019943:Amino Acid Substitution / Q000235:genetics; D003062:Codon / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D006086:Graft vs Host Disease / Q000235:genetics*; D019337:Hematologic Neoplasms / Q000235:genetics / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D006579:Heterozygote; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000235:genetics*; D011110:Polymorphism, Genetic; D035781:Siblings
D003062:Codon; D019408:Platelet Endothelial Cell Adhesion Molecule-1