title: [Expression of laminin and laminin receptor in gestational trophoblastic tumor and its significance].
abstract: OBJECTIVE
  This study was conducted to detect the expression of laminin (LN) and laminin receptor (LN-R) in the specimens of hydatidiform mole (HM), invasive mole (IM) and choriocarcinoma(CC), respectively.
  
  
  METHODS
  The immunohistological staining method was used.
  
  
  RESULTS
  It was found that the level of the laminin expression was higher in the specimens of choriocarcinoma at more advanced stage.
  
  
  CONCLUSIONS
  The results suggest that there may be relations between the invasion and metastasis of choriocacinoma cell and the malignant degree of this disease, chemotherapy has some effect on the expression of LN and LN-R in gestational trophablastic tumor (GTT), and that LN and LN-R may be of potential value in GTT treatment. However, referring whether LN and LN-R could be used as clinical prognosticators, further studies will be needed.
authors.affiliation: Department of Obstetric and Gynecology, The First Hospital, Xi'an Jiao Tong Univeristy, China.
authors.forename: Rui-fang
authors.initials: RF
authors.lastname: An
authors.forename: Shu
authors.initials: S
authors.lastname: Wang
authors.forename: Yong-ai
authors.initials: YA
authors.lastname: Zhang
authors.forename: Xiao-qin
authors.initials: XQ
authors.lastname: Bai
mesh_terms: D000328:Adult; D002822:Choriocarcinoma / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000378:metabolism / Q000473:pathology; D002820:Hydatidiform Mole, Invasive / Q000378:metabolism / Q000473:pathology; D007797:Laminin / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011247:Pregnancy; D017474:Receptors, Laminin / Q000096:biosynthesis* / Q000235:genetics; D014328:Trophoblastic Neoplasms / Q000378:metabolism* / Q000473:pathology; D014594:Uterine Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D007797:Laminin; D017474:Receptors, Laminin