Particulate delivery systems for biodefense subunit vaccines.
Expanding identification of potentially protective subunit antigens and correlates of protection has provided a basis for the introduction of safer vaccines. Despite encouraging results in animal models, the significant potential of particulate delivery systems in vaccine design has not yet translated into effective vaccines available for use in humans. This review article will focus on the current status of the development of particulate vaccines, mainly liposomes and bio-degradable polymers, against potential agents for biowarfare: plague, anthrax, botulinum, and smallpox; and filoviruses: Marburg and Ebola.
Bramwell
Vincent W
VW
School of Pharmacy, University of London, 29-39 Brunswick Square, London, WC1N 1AX, UK.
Eyles
Jim E
JE
Oya Alpar
H
H
D000818:Animals; D000881:Anthrax / Q000517:prevention & control*; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D001672:Biocompatible Materials; D001694:Biological Warfare; D001906:Botulism / Q000517:prevention & control*; D002619:Chemical Warfare Agents / Q000506:poisoning; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D019344:Lactic Acid; D008081:Liposomes; D010930:Plague / Q000517:prevention & control*; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers; D012276:Ricin / Q000506:poisoning; D012899:Smallpox / Q000517:prevention & control*; D014765:Viral Vaccines / Q000008:administration & dosage*
D001428:Bacterial Vaccines; D001672:Biocompatible Materials; D002619:Chemical Warfare Agents; D008081:Liposomes; D011108:Polymers; D014765:Viral Vaccines; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D012276:Ricin