title: Epidermal growth factor A61G polymorphism and cardiac autonomic control in adults.
abstract: The authors examined the relationship between functional epidermal growth factor gene A61G polymorphism and cardiac autonomic control in a sample of 75 young adults. Heart rate, preejection period, and respiratory sinus arrhythmia were measured continuously during rest and a set of challenging tasks. The functional G allele of the epidermal growth factor gene was associated with lower heart rate F(5,32), 6.92, p = 0.014, eta2 = 0.19, and higher respiratory sinus arrhythmia F(5,32), 4.71, p = 0.038, eta2 = 0.14, among women during the rest, but was not related to with cardiovascular reactivity for challenges in women or in men. The present findings suggest that epidermal growth factor A61G polymorphism is associated with cardiac control in women.
authors.affiliation: Department of Psychology, University of Helsinki, P. O. Box 9, FIN-00014 University of Helsinki, Finland.
authors.forename: Sampsa
authors.initials: S
authors.lastname: Puttonen
authors.forename: Liisa
authors.initials: L
authors.lastname: Keltikangas-Järvinen
authors.forename: Marko
authors.initials: M
authors.lastname: Elovainio
authors.forename: Mika
authors.initials: M
authors.lastname: Kivimäki
authors.forename: Riikka
authors.initials: R
authors.lastname: Rontu
authors.forename: Terho
authors.initials: T
authors.lastname: Lehtimäki
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001341:Autonomic Nervous System / Q000502:physiology*; D004562:Electrocardiography; D004815:Epidermal Growth Factor / Q000235:genetics* / Q000502:physiology; D005260:Female; D005838:Genotype; D015438:Health Behavior; D006321:Heart / Q000502:physiology*; D006801:Humans; D008297:Male; D010275:Parasympathetic Nervous System / Q000502:physiology; D011110:Polymorphism, Genetic / Q000235:genetics; D011930:Reaction Time / Q000502:physiology; D013216:Reflex, Startle / Q000502:physiology; D012727:Sex Characteristics; D013315:Stress, Psychological / Q000503:physiopathology
chemical_list: D004815:Epidermal Growth Factor