Axis formation: redundancy rules.
The role of BMP antagonists in the Spemann-Mangold organizer of vertebrate embryos is a controversial issue. A study using combined knock down of multiple antagonists finally reveals dramatic effects.
Niehrs
Christof
C
Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany. niehrs@dkfz-heidelberg.de
D000818:Animals; D019521:Body Patterning; D019485:Bone Morphogenetic Proteins / Q000037:antagonists & inhibitors*; D008954:Models, Biological; D020897:Organizers, Embryonic / Q000196:embryology / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D014714:Vertebrates / Q000196:embryology*
D019485:Bone Morphogenetic Proteins