title: Antitumor activity of crude extract and fractions from root tuber of Cynanchum auriculatum Royle ex Wight.
abstract: Antitumor activity of the ethanol extract from the root tuber of Cynanchum auriculatum Royle ex Wight and four fractions of the ethanol extract were investigated, both in vitro and in vivo. The five samples exhibited cytotoxic activity on human tumor cell lines K562, SHG44, HCT-8, A549, PC3, in vitro and inhibition in mouse implanted sarcoma S180, in vivo. Among the five samples, fraction E was noted to be of the highest antitumor activity.
authors.affiliation: School of Pharmacy, Second Military Medical University, Shanghai 200433, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Shan
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
authors.forename: Chuan
authors.initials: C
authors.lastname: Zhang
authors.forename: Run-Hui
authors.initials: RH
authors.lastname: Liu
authors.forename: Juan
authors.initials: J
authors.lastname: Su
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D031105:Cynanchum; D004305:Dose-Response Relationship, Drug; D006801:Humans; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D012510:Sarcoma 180 / Q000473:pathology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts