title: Increased risk of breast cancer development after diagnosis of salivary gland tumour.
abstract: The aim of this study was to evaluate whether patients with salivary gland tumours are at increased risk of developing breast cancer. A retrospective cohort study was performed. Female patients (n = 439) with a salivary gland tumour (major and minor) were included. The diagnosis was confirmed histologically. The median follow-up was 5.4 years. Fifteen patients out of 439 with a salivary gland tumour subsequently developed breast cancer, with a mean time interval of 64 months. On the basis of incidence rates in the general population 5.93 breast cancers would be expected. The standardised incidence ratio (SIR) was 2.5 (95% confidence interval: 1.4-4.2; P = 0.003). Increased SIRs were also observed for other solid malignancies, but the numbers were small (n < 5). It is concluded that female patients with a salivary gland tumour have a 2.5 times increased risk of developing breast cancer. Breast screening of these patients is therefore recommended.
authors.affiliation: Department of Head and Neck Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, Amsterdam 1066, The Netherlands.
authors.forename: Caroline D
authors.initials: CD
authors.lastname: In der Maur
authors.forename: Willem J
authors.initials: WJ
authors.lastname: Klokman
authors.forename: Floor E
authors.initials: FE
authors.lastname: van Leeuwen
authors.forename: I Bing
authors.initials: IB
authors.lastname: Tan
authors.forename: Emiel J Th
authors.initials: EJ
authors.lastname: Rutgers
authors.forename: Alfons J M
authors.initials: AJ
authors.lastname: Balm
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000453:epidemiology*; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000453:epidemiology*; D009426:Netherlands / Q000453:epidemiology; D012468:Salivary Gland Neoplasms / Q000453:epidemiology*