title: Local delivery of antineoplastic agents by controlled-release polymers for the treatment of malignant brain tumours.
abstract: Recent advances in the treatment of malignant brain tumours have focused on the development of targeted local delivery of therapeutic agents, which combine various antineoplastic strategies that include cytotoxic, anti-angiogenic and immunomodulatory mechanisms, among others. The introduction of local delivery devices for sustained administration of antineoplastic agents represents a new opportunity to effectively treat these malignancies by facilitating the intracranial administration of safe and clinically efficacious doses for prolonged periods of time in a controlled fashion. This technology circumvents the need for high systemic doses with potentially harmful toxicities, bypasses the blood-brain barrier and can be tailored to deliver new agents with complex pharmacological properties. Based on local delivery strategies, new delivery systems, including convection-enhanced delivery and microchips, have been developed. As a result, recent advances in tumour biology have been adopted as potentially translatable treatments and are undergoing preclinical and clinical evaluation at present. These novel approaches could improve the prognosis of patients with these tumours.
authors.affiliation: Department of Neurological Surgery, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Meyer 7-113, Baltimore, MD 21287, USA.
authors.forename: Shaan M
authors.initials: SM
authors.lastname: Raza
authors.forename: Gustavo
authors.initials: G
authors.lastname: Pradilla
authors.forename: Federico G
authors.initials: FG
authors.lastname: Legnani
authors.forename: Quoc Anh
authors.initials: QA
authors.lastname: Thai
authors.forename: Alessandro
authors.initials: A
authors.lastname: Olivi
authors.forename: Jon D
authors.initials: JD
authors.lastname: Weingart
authors.forename: Henry
authors.initials: H
authors.lastname: Brem
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D003692:Delayed-Action Preparations / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D011108:Polymers / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D011108:Polymers