Cell biology: master regulators of sealing and healing.
The protective layer of the epidermis in Drosophila (cuticle) and mice (stratum corneum) are structurally unrelated. Yet new evidence suggests a conserved transcription factor, Grainyhead, controls both their development and the means by which both structures repair themselves.
Stramer
Brian
B
Department of Physiology and Biochemistry, University of Bristol, UK.
Martin
Paul
P
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004296:Dopa Decarboxylase / Q000378:metabolism; D004330:Drosophila / Q000235:genetics / Q000502:physiology*; D029721:Drosophila Proteins; D004817:Epidermis / Q000254:growth & development*; D005786:Gene Expression Regulation; D051379:Mice / Q000235:genetics / Q000502:physiology*; D009687:Nuclear Proteins; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism; D014945:Wound Healing / Q000235:genetics / Q000502:physiology*
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; C512897:ELF1 protein, human; C512896:Elf1 protein, mouse; D009687:Nuclear Proteins; D014157:Transcription Factors; C062330:grh protein, Drosophila; D014446:Tyrosine 3-Monooxygenase; D004296:Dopa Decarboxylase