Is there any difference in anesthetic management of biliary atresia and glycogen storage disease patients undergoing liver transplantation?
BACKGROUND
The purpose of the study was to compare the intraoperative blood glucose changes and the dosage of glucose infused between biliary atresia and glycogen storage disease (GSD) patients undergoing living donor liver transplantation (LDLT).


METHODS
The anesthesia records of biliary atresia and GSD patients undergoing LDLT were reviewed retrospectively. The levels of intraoperative blood glucose before operation, after induction of anesthesia, in the dissection, anhepatic, 10 min after reperfusion, and at the end of operation, as well as the dosage glucose infused, were compared between groups. The Mann-Whitney U test was used for statistical analysis; P < 0.05 was regarded as significant.


RESULTS
Seventy-two biliary atresia patients were grouped into group I (GI) and 8 GSD patients into group II (GII). The blood glucose levels of both groups increased after operation and remained hyperglycemic, around 100-300 mg/dl, until the end of the operation. The mean glucose amounts infused were 2.7 +/- 1.9 and 2.5 +/- 1.15 mg/kg/min for GI and GII, respectively.


CONCLUSIONS
No significant difference was found in the anesthetic management between groups. The only difference was that the GSD patients required continuous glucose supply the night before the operation, while biliary atresia patients did not.
Jawan
Bruno
B
Department of Anesthesiology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University, Taipei, Taiwan, Republic of China.
Tseng
Chia-Chih
CC
Chen
Yaw-Sen
YS
Wang
Chih-Chi
CC
Cheng
Yu-Fan
YF
Huang
Tung-Liang
TL
Eng
Hock-Liew
HL
Chiu
King-Wah
KW
Wang
Shir-Hor
SH
Lin
Chih-Che
CC
Lin
Tsan-Shiun
TS
Liu
Yueh-Wei
YW
Chen
Chao-Long
CL
D000293:Adolescent; D000758:Anesthesia / Q000379:methods*; D001656:Biliary Atresia / Q000097:blood / Q000601:surgery*; D001786:Blood Glucose / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005440:Fluid Therapy; D006008:Glycogen Storage Disease / Q000097:blood / Q000601:surgery*; D006801:Humans; D007223:Infant; D016031:Liver Transplantation; D016343:Monitoring, Intraoperative; D012189:Retrospective Studies
D001786:Blood Glucose