CD4(+) CD25(+) T cells prevent arthritis associated with Borrelia vaccination and infection.
CD4(+) CD25(+) T cells are a population of regulatory T cells associated with control of arthritis in anti-interleukin-17 antibody-treated Borrelia-vaccinated and challenged gamma interferon-deficient mice. Here, we present direct evidence that adoptive transfer of enriched CD4(+) CD25(+) T cells from these mice can prevent the development of arthritis in Borrelia-vaccinated and challenged mice. These findings establish a major role for CD4(+) CD25(+) T cells in the prevention of arthritis in Borrelia-vaccinated and challenged animals.
Nardelli
Dean T
DT
University of Wisconsin, Wisconsin State Laboratory of Hygiene, 465 Henry Mall, Madison, WI 53706, USA.
Cloute
Joseph P
JP
Luk
K H Kevin
KH
Torrealba
Jose
J
Warner
Thomas F
TF
Callister
Steven M
SM
Schell
Ronald F
RF
D000818:Animals; D000906:Antibodies / Q000008:administration & dosage; D001169:Arthritis, Experimental / Q000276:immunology* / Q000382:microbiology / Q000517:prevention & control*; D025065:Borrelia burgdorferi / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D004487:Edema; D007371:Interferon-gamma / Q000172:deficiency / Q000235:genetics; D020381:Interleukin-17 / Q000276:immunology; D007596:Joints / Q000473:pathology; D008193:Lyme Disease / Q000150:complications / Q000276:immunology* / Q000473:pathology; D022123:Lyme Disease Vaccines / Q000008:administration & dosage / Q000276:immunology; D051379:Mice; D018345:Mice, Knockout; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014611:Vaccination
D000906:Antibodies; D020381:Interleukin-17; D022123:Lyme Disease Vaccines; D007371:Interferon-gamma