Influence of doxorubicin and carnosine on the standard 12-lead electrocardiogram in rabbits.
Doxorubicin (DOX) is an anthracycline antibiotic with a potent anticancer activity used against human neoplasms. Doxorubicin causes numerous adverse effects i.e., toxic effect on the cardiovascular system of experimental animals and humans. DOX may provoke a few types of cardiomyopathies: an acute, subacute, chronic and late-onset one. Changes in ECG can be observed at any stage of cardiovascular abnormalities. Abnormal ECG findings may initially be transient in character, whereas continued use of anthracyclines may lead to their fixation. ECG has been suggested as one of the methods allowing to detect cardiotoxicity of anthracycline antibiotics. The usefulness of ECG in assessment of anthracycline cardiotoxicity in experimental animals has been indicated by various authors. In our experiments, we wanted to find out whether carnosine (CAR)--a naturally occurring antioxidant, a dipeptide commonly occurring in the human organism, can influence the potential changes in standard ECG of DOX-treated rabbits, which could indicate its cardioprotective effect.
Dzielska-Olczak
Małgorzata
M
Department of Pharmacology, Medical University of Lódź, 1 Muszyńskiego Str., PL 90-151 Lódź. goska1956@op.pl
Graczyk-Wojciechowska
Julita
J
Pakulska
Wanda
W
Zieba
Remigiusz
R
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002336:Carnosine / Q000494:pharmacology*; D004317:Doxorubicin / Q000494:pharmacology*; D004562:Electrocardiography / Q000187:drug effects*; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D011817:Rabbits
D000900:Anti-Bacterial Agents; D004317:Doxorubicin; D002336:Carnosine