title: Improved solution- and solid-phase preparation of hydroxamic acids from esters.
abstract: The addition of small amounts of solid KCN to solution and solid-phase esters in THF/MeOH/50% aqueous NH2OH increases the efficiency of their transformation to the corresponding hydroxamic acids.
authors.affiliation: Drug Discovery, Johnson & Johnson Pharmaceutical Research and Development, Spring House, Pennsylvania 19446-0776, USA. cho@prius.jnj.com
authors.forename: Chih Y
authors.initials: CY
authors.lastname: Ho
authors.forename: Eric
authors.initials: E
authors.lastname: Strobel
authors.forename: Janet
authors.initials: J
authors.lastname: Ralbovsky
authors.forename: Robert A
authors.initials: RA
authors.lastname: Galemmo
mesh_terms: D002384:Catalysis; D004952:Esters; D006877:Hydroxamic Acids / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D015394:Molecular Structure
chemical_list: D004952:Esters; D006877:Hydroxamic Acids; D007202:Indicators and Reagents