title: A supramolecular approach to multivalent target-specific MRI contrast agents for angiogenesis.
abstract: The synthesis of a cyclic peptide-Gd(III)DTPA molecule equipped with biotin is presented, yielding a well-defined multivalent MRI contrast agent after its coupling to avidin.
authors.affiliation: Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, Eindhoven, The Netherlands.
authors.forename: Anouk
authors.initials: A
authors.lastname: Dirksen
authors.forename: Sander
authors.initials: S
authors.lastname: Langereis
authors.forename: Bas F M
authors.initials: BF
authors.lastname: de Waal
authors.forename: Marcel H P
authors.initials: MH
authors.lastname: van Genderen
authors.forename: Tilman M
authors.initials: TM
authors.lastname: Hackeng
authors.forename: E W
authors.initials: EW
authors.lastname: Meijer
mesh_terms: D001360:Avidin / Q000737:chemistry; D001710:Biotin / Q000737:chemistry; D003287:Contrast Media / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008958:Models, Molecular; D015394:Molecular Structure; D018919:Neovascularization, Physiologic; D017186:Titrimetry
chemical_list: D003287:Contrast Media; D001360:Avidin; D001710:Biotin