Synthesis of polymeric thiazolidinediones and L-ascorbic acid towards the development of insulin-sensitizer.
Polymers, containing 5-(4-O-methylacryloylbenzyl)thiazolidine-2,4-dione [MABTZD]; poly (MABTZD), poly(MABTZD-co-AA) and poly(MABTZD-co-AMAA), were prepared, and identified by FT-IR, 1H- and 13C-NMR spectra. The MABTZD unit contents in poly(MABTZD-co-AA) and poly(MABZD-co-AMAA) were 11.3 and 27.7 mol %, respectively. The number average molecular weights of the polymers, as determined by GPC, ranged from 16,800 to 22,300, and with polydispersity indices of 1.2-1.4.
Lee
Sun Mi
SM
College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Korea.
Jeon
Raok
R
D000818:Animals; D001205:Ascorbic Acid / Q000737:chemistry*; D002460:Cell Line; D002522:Chlorocebus aethiops; D004355:Drug Stability; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D008970:Molecular Weight; D047495:PPAR gamma / Q000378:metabolism*; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045162:Thiazolidinediones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D007004:Hypoglycemic Agents; D047495:PPAR gamma; D011108:Polymers; D045162:Thiazolidinediones; D001205:Ascorbic Acid