[Differential genetic pathway of duct and acinar carcinomas of the pancreas].
Genetic pathways of various types of pancreatic carcinoma are described. There are many differences in the genetic pathway between duct carcinogenesis and acinar carcinogensis. K-ras mutation is a key event in the early stage of pancreatic duct carcinogenesis and various gene alterations accumulate from precancerous ductal lesions until the development of carcinomas. Therefore, inhibition of K-ras gene mutation might be important for the prevention, and the combination of therapeutic agents against some target genes might be needed for therapy of ductal carcinomas.
Tsutsumi
Masahiro
M
Department of Pathology, Saiseikai Chuwa Hospital, Nara, Japan.
D000818:Animals; D018267:Carcinoma, Acinar Cell / Q000209:etiology / Q000235:genetics*; D021441:Carcinoma, Pancreatic Ductal / Q000209:etiology / Q000235:genetics*; D006224:Cricetinae; D019942:Genes, p16; D016158:Genes, p53 / Q000235:genetics; D011905:Genes, ras / Q000235:genetics; D006801:Humans; D019656:Loss of Heterozygosity; D009154:Mutation; D010190:Pancreatic Neoplasms / Q000209:etiology / Q000235:genetics*; D051381:Rats