title: Optimal size of a monocusp patch for reconstruction of a hypoplastic pulmonary root: an experimental study in pigs.
abstract: BACKGROUND
  Transannular patching is often performed to relieve congenital pulmonary stenosis, especially in tetralogy of Fallot. Theoretically, a monocusp patch can reduce patch-related pulmonary regurgitation, but the optimal size relation between the implant and the native hypoplastic pulmonary root is not well defined.
  
  
  METHODS
  In 11 pigs, peak pressure gradient and regurgitation fraction across the pulmonary root were measured. During cardiopulmonary bypass, two cusps including the pulmonary artery wall were resected and the midpoint of the free margin of the remaining cusp was sutured to the sinus wall to imitate a hypoplastic pulmonary root. Transannular patching was performed using a noncoronary segment of a porcine aortic root. After discontinuation of cardiopulmonary bypass, all measurements were repeated. Thereafter, the cusp of the patch was resected, and all measurements again repeated. Anatomic dimensions were determined after the pigs had been sacrificed.
  
  
  RESULTS
  Regurgitation fraction increased from 0.2% +/- 3.4% at baseline to 15.5% +/- 6.2% after reconstruction with a monocusp patch and to 60.0 +/- 18.6% after the cusp of the monocusp patch had been resected (p < 0.001). The median peak pressure gradient increased from 0 to 1 to 6 mm Hg (p = 0.013), respectively. The regurgitation fraction negatively correlated with the ratio of the length of the monocusp patch to that of the hypoplastic pulmonary root (r = -0.63, p = 0.037).
  
  
  CONCLUSIONS
  A monocusp patch for reconstruction of a hypoplastic pulmonary root results in significantly less regurgitation than a nonvalved patch of the same size, while the peak pressure gradient remains normal. The lowest regurgitation fraction was observed with a monocusp patch two-times the length of the circumference of the hypoplastic pulmonary root.
authors.affiliation: Department of Cardiac Surgery, University of Luebeck, Luebeck, Germany.
authors.forename: J F Matthias
authors.initials: JF
authors.lastname: Bechtel
authors.forename: Peter E
authors.initials: PE
authors.lastname: Lange
authors.forename: Hans H
authors.initials: HH
authors.lastname: Sievers
mesh_terms: D000818:Animals; D002315:Cardiopulmonary Bypass; D004195:Disease Models, Animal; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D011651:Pulmonary Artery / Q000601:surgery*; D011664:Pulmonary Valve / Q000033:anatomy & histology / Q000637:transplantation*; D011665:Pulmonary Valve Insufficiency / Q000209:etiology / Q000517:prevention & control*; D011666:Pulmonary Valve Stenosis / Q000601:surgery*; D013536:Suture Techniques; D013552:Swine; D013771:Tetralogy of Fallot / Q000601:surgery