title: Endothelin-1 concentrations in cord blood of neonates with meconium-stained amniotic fluid.
abstract: BACKGROUND
  The effects of meconium-stained amniotic fluid (MSAF) on cord blood endothelin-1 (ET-1) concentrations have not been explored.
  
  
  OBJECTIVE
  The aim of this study was to verify whether MSAF influences ET-1 cord blood concentrations in healthy term neonates.
  
  
  METHODS
  Using an enzyme-linked immunosorbent assay, plasma ET-1 concentrations were determined in 30 healthy term neonates with MSAF, and in 15 healthy term neonates without MSAF. The two groups were of the same gestational age, weight, Apgar score, cord blood pH, base excess, and hematocrit values, as well as systolic and diastolic blood pressures.
  
  
  RESULTS
  ET-1 plasma concentrations were not significantly different between the two groups and did not correlate with cord blood pH or base excess values.
  
  
  CONCLUSIONS
  Our data demonstrate that meconium passage does not induce ET-1 secretion.
authors.affiliation: Department of Pediatric Sciences, University of Messina, Messina, Italy. marina.gemelli@unime.it
authors.forename: Marina
authors.initials: M
authors.lastname: Gemelli
authors.forename: Rosa
authors.initials: R
authors.lastname: Manganaro
authors.forename: Carmelo
authors.initials: C
authors.lastname: Mamì
authors.forename: Michele
authors.initials: M
authors.lastname: Buemi
authors.forename: Antonina
authors.initials: A
authors.lastname: Paolata
authors.forename: Teresa
authors.initials: T
authors.lastname: Marrone
authors.forename: Lucia
authors.initials: L
authors.lastname: Marseglia
mesh_terms: D000653:Amniotic Fluid; D001034:Apgar Score; D001794:Blood Pressure; D019332:Endothelin-1 / Q000097:blood*; D005312:Fetal Blood / Q000737:chemistry / Q000378:metabolism*; D005865:Gestational Age; D006400:Hematocrit; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D008470:Meconium
chemical_list: D019332:Endothelin-1