title: Evaluation of the clinical efficacy of prokinetic drugs in the management of post-operative ileus: can retrospective data help us?
abstract: The objectives of the study were to determine whether retrospective data can be used to answer questions about the efficacy of prokinetic agents when used to treat horses with post-operative ileus (POI). We describe prevalence and mortality of POI with reference to treatment with four prokinetic agents. By combining data from two Hospitals a study population of 55 horses with POI following pedunculated lipoma obstruction (PLO) was established. Univariable and multivariable associations were determined between short term survival and potential explanatory variables. With death as outcome in multivariable models, breed and hospital were significantly associated with outcome but the use of prokinetic agents was not (P=0.15). However, sample size estimates indicate the low power of this study to detect differences in outcome. It was not possible definitively to evaluate the efficacy of prokinetics as treatment for POI following PLO using retrospective data. The data were suggestive of limited efficacy of prokinetics as treatment for POI. It is postulated that the identified association between hospital and survival reflects differences in clinician decision making. The study highlights the need for further prospective studies using randomised clinical trials to evaluate accurately the efficacy of prokinetic agents. This report illustrates difficulties with performing retrospective analysis of clinical data to determine the efficacy of treatment regimes.
authors.affiliation: Equine Division, Department of Veterinary Clinical Science and Animal Husbandry, University of Liverpool, Leahurst, Neston, Wirral, Liverpool CH64 7TE, UK. m.a.smith@liv.ac.uk
authors.forename: M A
authors.initials: MA
authors.lastname: Smith
authors.forename: G B
authors.initials: GB
authors.lastname: Edwards
authors.forename: B L
authors.initials: BL
authors.lastname: Dallap
authors.forename: P J
authors.initials: PJ
authors.lastname: Cripps
authors.forename: C J
authors.initials: CJ
authors.lastname: Proudman
mesh_terms: D000818:Animals; D020117:Cisapride / Q000627:therapeutic use; D013505:Digestive System Surgical Procedures / Q000009:adverse effects*; D004917:Erythromycin / Q000627:therapeutic use; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006734:Horse Diseases / Q000188:drug therapy* / Q000209:etiology; D006736:Horses; D045823:Ileus / Q000150:complications / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D008012:Lidocaine / Q000627:therapeutic use; D008787:Metoclopramide / Q000627:therapeutic use; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D005765:Gastrointestinal Agents; D004917:Erythromycin; D008012:Lidocaine; D008787:Metoclopramide; D020117:Cisapride