title: Synthesis and biological studies of yohimbine derivatives on human alpha2C-adrenergic receptors.
abstract: A series of yohimbine derivatives was synthesized and evaluated for binding affinity at the human alpha(2C)-adrenergic receptors expressed in Chinese hamster ovary cells. It has been found that compound 5 shows a higher affinity for alpha(2C)-AR than the parent compound yohimbine 1, thereby illustrating that the nature of the linkers affect binding potencies on these receptors.
authors.affiliation: Department of Pharmaceutical Sciences, University of Tennessee, Health Science Center, Memphis, 38163, USA.
authors.forename: Suni M
authors.initials: SM
authors.lastname: Mustafa
authors.forename: Supriya A
authors.initials: SA
authors.lastname: Bavadekar
authors.forename: Guoyi
authors.initials: G
authors.lastname: Ma
authors.forename: Bob M
authors.initials: BM
authors.lastname: Moore
authors.forename: Dennis R
authors.initials: DR
authors.lastname: Feller
authors.forename: Duane D
authors.initials: DD
authors.lastname: Miller
mesh_terms: D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D006801:Humans; D051379:Mice; D011485:Protein Binding; D018341:Receptors, Adrenergic, alpha-2 / Q000187:drug effects* / Q000378:metabolism; D015016:Yohimbine / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D018341:Receptors, Adrenergic, alpha-2; D015016:Yohimbine