title: [Treatment of chronic copper poisoning in dairy sheep with oral ammonium molybdate and sodium sulphate ].
abstract: Four weeks after the introduction of a new ration, a herd of sheep in the Swiss midland area was affected by depression, anorexia, decreased milk production, anemia, hemoglobinuria and frequent recumbency. Seventeen ewes died within a few days. A diagnosis of chronic copper poisoning was based on the results of feed analysis, histopathological findings and the toxicological examination of liver tissue. The remaining sheep were treated with oral ammonium molybdate and sodium sulfate, which together provide an inexpensive alternative to the chelator D-penicillamine.This combination not only prevents further copper intake, but also supports its elimination from the hepatocellular storage compartments. Serum copper levels have been determined to monitor the mobilization of copper following this antidote therapy.
authors.affiliation: Institut für Veterinärpharmakologie und -toxikologie der Universität Zürich. jacqueline.kupper@vetpharm.unizh.ch
authors.forename: J
authors.initials: J
authors.lastname: Kupper
authors.forename: A
authors.initials: A
authors.lastname: Bidaut
authors.forename: A
authors.initials: A
authors.lastname: Waldvogel
authors.forename: B
authors.initials: B
authors.lastname: Emmenegger
authors.forename: H
authors.initials: H
authors.lastname: Naegeli
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002400:Cathartics / Q000627:therapeutic use*; D003300:Copper / Q000097:blood / Q000506:poisoning*; D005260:Female; D008982:Molybdenum / Q000627:therapeutic use*; D011041:Poisoning / Q000188:drug therapy / Q000662:veterinary; D012756:Sheep; D012757:Sheep Diseases / Q000139:chemically induced* / Q000188:drug therapy; D013431:Sulfates / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D002400:Cathartics; D013431:Sulfates; C012036:sodium sulfate; D003300:Copper; D008982:Molybdenum; C022175:ammonium molybdate