title: Infarctive purpura hemorrhagica in five horses.
abstract: Five horses were examined because of signs of muscle stiffness, colic, or both. All 5 had been exposed to Streptococcus equi within 3 weeks prior to examination or had high serum titers of antibodies against the M protein of S equi. Horses had signs of unrelenting colic-like pain and focal areas of muscle swelling. Four horses were euthanatized. The fifth responded to treatment with penicillin and dexamethasone; after 3 weeks of treatment with dexamethasone, prednisolone was administered for an additional 10 weeks. Common hematologic and serum biochemical abnormalities included neutrophilia with a left shift and toxic changes, hyperproteinemia, hypoalbuminemia, and high serum creatine kinase and aspartate transferase activities. Necropsy revealed extensive infarction of the skeletal musculature, skin, gastrointestinal tract, pancreas, and lungs. Histologic lesions included leukocytoclastic vasculitis in numerous tissues and acute coagulative necrosis resembling infarction. These horses appeared to have a severe form of purpura hemorrhagica resembling Henoch-Schönlein purpura in humans and characterized by infarction of skeletal muscles. Early recognition of focal muscle swelling, abdominal discomfort, neutrophilia, hypoalbuminemia, and high serum creatine kinase activity combined with antimicrobial and corticosteroid treatment may enhance the likelihood of a successful outcome.
authors.affiliation: Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA.
authors.forename: Heather J
authors.initials: HJ
authors.lastname: Kaese
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Valberg
authors.forename: David W
authors.initials: DW
authors.lastname: Hayden
authors.forename: Julia H
authors.initials: JH
authors.lastname: Wilson
authors.forename: Patricia
authors.initials: P
authors.lastname: Charlton
authors.forename: Trevor R
authors.initials: TR
authors.lastname: Ames
authors.forename: Ghanem M
authors.initials: GM
authors.lastname: Al-Ghamdi
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000097:blood; D017809:Fatal Outcome; D005260:Female; D006734:Horse Diseases / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006736:Horses; D011695:IgA Vasculitis / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008297:Male; D013290:Streptococcal Infections / Q000150:complications / Q000662:veterinary; D018502:Streptococcus equi / Q000276:immunology / Q000472:pathogenicity
chemical_list: D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial