title: Benzothieno[3,2-b]indole derivatives as potent selective estrogen receptor modulators.
abstract: A series of estrogen receptor ligands based on benzothieno[3,2-b]indole were synthesized and their binding affinity for estrogen receptor subtypes (ERalpha and ERbeta) and effects on mouse uterus and bone were evaluated. Some of these compounds showed strong binding affinity to ER and significantly increased the bone mineral density of ovariectomized mice.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences.
authors.forename: Qinggang
authors.initials: Q
authors.lastname: Ji
authors.forename: Jie
authors.initials: J
authors.lastname: Gao
authors.forename: Junbo
authors.initials: J
authors.lastname: Wang
authors.forename: Chunhao
authors.initials: C
authors.lastname: Yang
authors.forename: Xin
authors.initials: X
authors.lastname: Hui
authors.forename: Xueming
authors.initials: X
authors.lastname: Yan
authors.forename: Xihan
authors.initials: X
authors.lastname: Wu
authors.forename: Yuyuan
authors.initials: Y
authors.lastname: Xie
authors.forename: Ming-Wei
authors.initials: MW
authors.lastname: Wang
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D051379:Mice; D020845:Selective Estrogen Receptor Modulators / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D007211:Indoles; D020845:Selective Estrogen Receptor Modulators