Kainate receptors and mossy fiber LTP.
There is considerable interest in understanding long-term potentiation (LTP) of glutamatergic synaptic transmission because the molecular mechanisms involved in its induction and expression are believed to be critical for learning and memory. There are two distinct forms of LTP. One type is triggered by synaptic activation of NMDA receptors and the other is NMDA receptor-independent. The latter type of LTP has been mostly studied at mossy fiber/CA3 synapses. Here we summarise some of our recent studies concerning the mechanisms of the induction of the NMDA receptor-independent form of LTP at these CA3 synapses. This form of LTP is triggered by the synaptic activation of kainate receptors. We also address the importance of Ca2+ availability in the extracellular environment and the release of Ca2+ from intracellular stores for this form of LTP.
Bortolotto
Zuner A
ZA
MRC Centre for Synaptic Plasticity, University of Bristol, Department of Anatomy, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK. Z.A.Bortolotto@bris.ac.uk
Nistico
Robert
R
More
Julia C
JC
Jane
David E
DE
Collingridge
Graham L
GL
D000818:Animals; D020013:Calcium Signaling / Q000187:drug effects; D005110:Extracellular Space / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D017774:Long-Term Potentiation / Q000187:drug effects*; D019599:Mossy Fibers, Hippocampal / Q000187:drug effects*; D018092:Kainic Acid Receptors / Q000187:drug effects*; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
D018092:Kainic Acid Receptors; D016194:Receptors, N-Methyl-D-Aspartate