title: Redox status of dogs with non-hodgkin lymphomas. An ESR study.
abstract: Free radical and antioxidant parameters in healthy dogs (n=10) and dogs with non-Hodgkin lymphomas (n=11) were measured in blood and lymph node tissue samples before chemotherapy. Enzymatic and other biochemical measurements were performed. We found that (i) free radical concentrations based on ESR spectra of tissues correlated with higher proliferative character; (ii) lymphoma cases showed an impaired antioxidant status; (iii) tumors with low oxidative burst capacity and higher reduced/oxidized glutathione ratio responded better to chemotherapy; and (iv) affected blood and lymph nodes were under strong oxidative stress.
authors.affiliation: Department of Internal Medicine and Clinics, Faculty of Veterinary Sciences, Szent István University, Budapest, Hungary. pvajdo@univet.hu
authors.forename: Péter
authors.initials: P
authors.lastname: Vajdovich
authors.forename: Tamás
authors.initials: T
authors.lastname: Kriska
authors.forename: Miklós
authors.initials: M
authors.lastname: Mézes
authors.forename: Piroska Ribiczey
authors.initials: PR
authors.lastname: Szabó
authors.forename: Nándor
authors.initials: N
authors.lastname: Balogh
authors.forename: András
authors.initials: A
authors.lastname: Bánfi
authors.forename: Attila
authors.initials: A
authors.lastname: Arany-Tóth
authors.forename: Tibor
authors.initials: T
authors.lastname: Gaál
authors.forename: Judit
authors.initials: J
authors.lastname: Jakus
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000032:analysis*; D049109:Cell Proliferation; D004283:Dog Diseases / Q000503:physiopathology*; D004285:Dogs; D005260:Female; D005609:Free Radicals / Q000097:blood*; D008228:Lymphoma, Non-Hodgkin / Q000503:physiopathology* / Q000662:veterinary*; D008297:Male; D018384:Oxidative Stress; D013057:Spectrum Analysis
chemical_list: D000975:Antioxidants; D005609:Free Radicals