[Comparative study 1,25-dihydroxycholecalciferols and 24,25-dihydroxycholecalciferols effect on ionized calcium level in blood plasma of patients with osteoporosis].
Comparative study results of vitamin's D active metabolites 1,25-dihydroxycholecalciferol (1,25(OH)2D3) and 24,25-dihydroxycholecalciferol (24,25(OH)2D3) effect on ionised calcium level in blood plasma of patients with postmenopause osteoporosis are described. Administration of 24,25(OH)2D3 for patients with osteoporosis leads to gradual stepped increase of ionised calcium level in blood plasma. This level remains normal and does not change in 2 weeks after cancelling of drug administration. Prescription of 1,25(OH)2D3 rapidly increases ionised calcium level in blood plasma and it's cancelling leads to normalisation of ionized calcium concentration in blood plasma during 1 week. Combination of two medicines causes summation of their effects. Administration of 24,25(OH)2D3 (10 mcg per 24 hours) and 1,25(OH)2D3 (0.5 mcg per 24 hours) doesn't cause any of incidental and allergic reactions.
Khodyrev
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VN
Spirichev
V B
VB
D015650:24,25-Dihydroxyvitamin D 3 / Q000008:administration & dosage*; D000284:Administration, Oral; D000368:Aged; D002117:Calcitriol / Q000008:administration & dosage*; D002118:Calcium / Q000097:blood*; D002413:Cations, Divalent / Q000097:blood; D005260:Female; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000097:blood* / Q000188:drug therapy; D017698:Postmenopause / Q000097:blood / Q000187:drug effects
D002413:Cations, Divalent; D015650:24,25-Dihydroxyvitamin D 3; D002117:Calcitriol; D002118:Calcium