title: Impaired and repaired inhibitory circuits in the epileptic human hippocampus.
abstract: This review focuses on the epileptic human temporal lobe, primarily on recent findings related to changes in hippocampal GABAergic interneuron circuits that have a central role in epileptogenesis. Relying on correlations to animal studies, we provide a functional interpretation of the different changes in perisomatic inhibition (controlling output synchrony) and dendritic inhibition (controlling input plasticity), and the potential consequences of the loss of interneuron-selective interneurons. The highly heterogeneous, but specific, alterations of GABAergic interneuron circuits have important implications for the pharmacotherapy of epilepsy.
authors.affiliation: Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, POB 67, H-1450, Hungary.
authors.forename: Zsófia
authors.initials: Z
authors.lastname: Maglóczky
authors.forename: Tamás F
authors.initials: TF
authors.lastname: Freund
mesh_terms: D000818:Animals; D064026:Calbindins; D004827:Epilepsy / Q000503:physiopathology*; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology* / Q000648:ultrastructure; D006801:Humans; D007395:Interneurons / Q000473:pathology / Q000648:ultrastructure; D009415:Nerve Net / Q000503:physiopathology*; D009433:Neural Inhibition / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D010320:Parvalbumins / Q000378:metabolism; D020127:Recovery of Function / Q000502:physiology*; D064030:S100 Calcium Binding Protein G / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D064026:Calbindins; D010320:Parvalbumins; D064030:S100 Calcium Binding Protein G; D005680:gamma-Aminobutyric Acid