Alkaloids of Aconitum laeve and their anti-inflammatory antioxidant and tyrosinase inhibition activities.
A lycoctonine-type norditerpenoid alkaloid, swatinine (1), along with four known norditerpenoid alkaloids, delphatine (3), lappaconitine (4), puberanine (5), and N-acetylsepaconitine (6), and were isolated from the aerial parts of Aconitum laeve Royle. Compound 2 has been isolated for the first time from a natural source. The structure of compound 1 was deduced on the basis of spectral data. The anti-inflammatory, antioxidant and tyrosinase inhibition studies on all six compounds have also been carried out.
Shaheen
Farzana
F
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Pakistan. farzanailyas@yahoo.com
Ahmad
Manzoor
M
Khan
Muhmud Tareq Hassan
MT
Jalil
Saima
S
Ejaz
Asma
A
Sultankhodjaev
Mukhlis N
MN
Arfan
Muhammad
M
Choudhary
Muhammad Iqbal
MI
Atta-ur-Rahman
D031841:Aconitum / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D005609:Free Radicals; D006801:Humans; D066298:In Vitro Techniques; D008958:Models, Molecular; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D035261:Plant Components, Aerial / Q000737:chemistry
D000470:Alkaloids; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D005609:Free Radicals; D014442:Monophenol Monooxygenase