title: Increasing the generalizability of economic evaluations: recommendations for the design, analysis, and reporting of studies.
abstract: OBJECTIVE
  Health technology assessment (HTA) is increasingly an international activity, and HTA agencies collaborate to avoid unnecessary duplication of effort. However, the sharing of the results from HTAs raises questions about their generalizability; namely, are the results of an HTA undertaken in one country relevant to another?
  
  
  METHODS
  This study presents recommendations for increasing the generalizability of economic evaluations. They represent an important component of HTAs and are commonly thought to have limited generalizability.
  
  
  RESULTS
  Recommendations are given for studies using patient-level data (i.e., evaluations conducted alongside clinical trials) and for studies using decision analytic modeling.
  
  
  CONCLUSIONS
  If implemented, the recommendations would increase the value for investments in HTA.
authors.affiliation: University of York, North Yorkshire, UK. chedir@york.ac.uk
authors.forename: Michael
authors.initials: M
authors.lastname: Drummond
authors.forename: Andrea
authors.initials: A
authors.lastname: Manca
authors.forename: Mark
authors.initials: M
authors.lastname: Sculpher
mesh_terms: D003299:Cooperative Behavior; D003362:Cost-Benefit Analysis; D003469:Culture; D003657:Decision Making; D017408:Guidelines as Topic; D006801:Humans; D007391:International Cooperation; D038622:Internationality; D018803:Models, Economic; D015203:Reproducibility of Results; D013673:Technology Assessment, Biomedical / Q000191:economics* / Q000592:standards*