The effects of intravenous lidocaine on pain during injection of medium- and long-chain triglyceride propofol emulsions.
Propofol formulated in medium- and long-chain triglycerides (MCT/LCT) is thought to cause less pain on injection. In this study we sought to determine if adding lidocaine to propofol-MCT/LCT is more effective in decreasing pain compared with propofol-MCT/LCT alone or conventional propofol-lidocaine mixtures. Seventy-five patients were randomized into three groups. Group A received conventional propofol-lidocaine mixtures with 20 mg lidocaine, group B received propofol-MCT/LCT with saline, and group C received propofol-MCT/LCT with 20 mg lidocaine. The incidence of pain was 24% in groups A and B and 4% in group C. The number needed to treat to prevent pain was 5. We conclude that propofol-MCT/LCT-lidocaine mixtures significantly reduce pain.
Yew
Woon Si
WS
Department of Anaesthesia and Surgical Intensive Care, Singapore General Hospital, Singapore.
Chong
Shin Yuet
SY
Tan
Kian Hian
KH
Goh
Meng Huat
MH
D000293:Adolescent; D000328:Adult; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects*; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000627:therapeutic use*; D004311:Double-Blind Method; D004655:Emulsions; D005079:Excipients; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008012:Lidocaine / Q000008:administration & dosage* / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000139:chemically induced* / Q000188:drug therapy*; D010147:Pain Measurement / Q000187:drug effects; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects*; D014280:Triglycerides
D018686:Anesthetics, Intravenous; D000779:Anesthetics, Local; D004655:Emulsions; D005079:Excipients; D014280:Triglycerides; D008012:Lidocaine; D015742:Propofol