Thymoma and multiple malignancies: a case of five synchronous neoplasms and literature review.
The presence of five discrete synchronous or metachronous primary neoplasms in a single patient is an extremely rare event. This is a report of a patient with a malignant (invasive) thymoma and four other independent primary neoplasms including: gliosarcoma, papillary thyroid cancer, meningioma and metastatic adenocarcinoma of the colon, found synchronously at autopsy. Thymoma patients appear to have an inherent predisposition towards developing additional neoplasms. Other than the thymoma, the presented patient had no obvious risk factors for neoplasia. This case provides evidence for an unusual syndrome of thymoma and multiple primary neoplasms. Further research is required to elucidate the mechanism of this association. Meanwhile, heightened awareness of this association may allow earlier detection and treatment of additional cancers in patients with a history of thymoma.
Welsh
James S
JS
Department of Human Oncology, University of Wisconsin School of Medicine, Madison, Wisconsin 53792, USA. welsh@humonc.wisc.edu
Thurman
Sarah A
SA
Howard
Steven P
SP
D000230:Adenocarcinoma / Q000150:complications / Q000556:secondary; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000150:complications / Q000473:pathology; D002291:Carcinoma, Papillary / Q000150:complications / Q000473:pathology; D003110:Colonic Neoplasms / Q000150:complications / Q000473:pathology; D005260:Female; D018316:Gliosarcoma / Q000150:complications / Q000473:pathology; D006801:Humans; D008577:Meningeal Neoplasms / Q000150:complications / Q000473:pathology; D008579:Meningioma / Q000150:complications / Q000473:pathology; D009378:Neoplasms, Multiple Primary; D013945:Thymoma / Q000150:complications* / Q000473:pathology; D013953:Thymus Neoplasms / Q000150:complications* / Q000473:pathology; D013964:Thyroid Neoplasms / Q000150:complications / Q000473:pathology