title: Does Helicobacter pylori play a role in upper respiratory tract inflammation? A case report.
abstract: Persistent isolated inflammation of the sphenoid sinus, an entity that is not diagnosed very often, poses a challenge to clinicians and researchers alike. Its features tend to suggest that its etiopathogenesis is different from that of more common forms of chronic rhinosinusitis. We report the case of a 54-year-old woman who had a history of distressing chronic postnasal drip and a globus sensation with opacification of the sphenoid sinus. She was diagnosed with gastroesophageal reflux, and Helicobacter pylori was detected in her gastric contents and in the inflamed mucosa of the sphenoid sinus, as well. Complete symptom relief was achieved only after she had undergone surgical sphenoidotomy and treatment with anti-H pylori medication. We discuss the potential for this ubiquitous gastric bacterium to play a role in at least some forms of chronic sinonasal inflammation.
authors.affiliation: Department of Otorhinolaryngology, Hospital de Pulido Valente, Lisbon. borges.dinis@netc.pt
authors.forename: Paulo Borges
authors.initials: PB
authors.lastname: Dinis
authors.forename: Maria Luz
authors.initials: ML
authors.lastname: Martins
authors.forename: João
authors.initials: J
authors.lastname: Subtil
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use; D005260:Female; D016481:Helicobacter Infections / Q000150:complications* / Q000188:drug therapy; D016480:Helicobacter pylori; D006801:Humans; D008875:Middle Aged; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000382:microbiology*; D015524:Sphenoid Sinusitis / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery
chemical_list: D000890:Anti-Infective Agents