title: In vitro and in vivo activities of DA-7867, a new oxazolidinone, against aerobic gram-positive bacteria.
abstract: In vitro and in vivo activities of DA-7867 were assessed against methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and penicillin-resistant Streptococcus pneumoniae. All isolates were inhibited by DA-7867 at <or=0.78 microg/ml, a four-times-lower concentration than that of inhibition by linezolid. For murine infection models, DA-7867 also exhibited greater efficacy than linezolid against all isolates tested.
authors.affiliation: Department of Microbiology, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, San 56-1, Shillim-9 dong, Kwanak-gu, Seoul 151-742, Korea.
authors.forename: Eun Jeong
authors.initials: EJ
authors.lastname: Yoon
authors.forename: Yeong Woo
authors.initials: YW
authors.lastname: Jo
authors.forename: Sung Hak
authors.initials: SH
authors.lastname: Choi
authors.forename: Tae Ho
authors.initials: TH
authors.lastname: Lee
authors.forename: Jae Keol
authors.initials: JK
authors.lastname: Rhee
authors.forename: Moohi
authors.initials: M
authors.lastname: Yoo
authors.forename: Mi Ja
authors.initials: MJ
authors.lastname: Shim
authors.forename: Eung Chil
authors.initials: EC
authors.lastname: Choi
mesh_terms: D000081:Acetamides / Q000494:pharmacology / Q000627:therapeutic use; D000332:Aerobiosis; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D024881:Drug Resistance, Bacterial; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D006095:Gram-Positive Cocci / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D000069349:Linezolid; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; C480487:DA-7867; D023303:Oxazolidinones; D000069349:Linezolid