title: Biosynthesized tea polyphenols inactivate Chlamydia trachomatis in vitro.
abstract: Biosynthesized tea polyphenols showed antichlamydial activity against Chlamydia trachomatis D/UW-3/Cx and L2/434/Bu using cell culture. The most active compounds were (-)-epigallocatechin gallate and (-)-epicatechin gallate, followed by (-)-epicatechin (EC). (+)-Epicatechin and (-)-epigallocatechin were intermediate. EC was the least toxic. These results warrant evaluation of tea polyphenols as topical antichlamydial agents.
authors.affiliation: Department of Virology 1, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku, Tokyo, Japan 162-8640. tochaben@gray.plala.or.jp
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yamazaki
authors.forename: Toshio
authors.initials: T
authors.lastname: Kishimoto
authors.forename: Sadashi
authors.initials: S
authors.lastname: Shiga
authors.forename: Kozue
authors.initials: K
authors.lastname: Sato
authors.forename: Toshikatsu
authors.initials: T
authors.lastname: Hagiwara
authors.forename: Miyuki
authors.initials: M
authors.lastname: Inoue
authors.forename: Nozomu
authors.initials: N
authors.lastname: Sasaki
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Ouchi
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Hara
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology*; D002392:Catechin / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology; D002692:Chlamydia trachomatis / Q000187:drug effects* / Q000254:growth & development; D005419:Flavonoids / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology*; D006367:HeLa Cells / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D059808:Polyphenols; D013662:Tea / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D013662:Tea; D002392:Catechin; C062669:epicatechin gallate; C045651:epigallocatechin gallate