Glaciapyrroles A, B, and C, pyrrolosesquiterpenes from a Streptomyces sp. isolated from an Alaskan marine sediment.
A Streptomyces sp. (NPS008187) isolated from a marine sediment collected in Alaska was found to produce three new pyrrolosesquiterpenes, glyciapyrroles A (1), B (2), and C (3), along with the known diketopiperazines cyclo(leucyl-prolyl) (4), cyclo(isoleucyl-prolyl) (5), and cyclo(phenylalanyl-prolyl) (6). The structures of 1, 2, and 3 were established using spectroscopic methods.
Macherla
Venkat R
VR
Nereus Pharmaceuticals, Inc., 10480 Wateridge Circle, San Diego, California 92121, USA.
Liu
Jehnan
J
Bellows
Christopher
C
Teisan
Sy
S
Nicholson
Benjamin
B
Lam
Kin S
KS
Potts
Barbara C M
BC
D000413:Alaska; D019015:Geologic Sediments; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D013302:Streptomyces / Q000737:chemistry*
D010456:Peptides, Cyclic; D011758:Pyrroles; D012717:Sesquiterpenes; C501803:glaciapyrrole A; C501804:glaciapyrrole B; C501805:glaciapyrrole C