Carbohydrates in peptide and protein design.
Monosaccharides and amino acids are fundamental building blocks in the assembly of nature's polymers. They have different structural aspects and, to a significant extent, different functional groups. Oligomerization gives rise to oligosaccharides and peptides, respectively. While carbohydrates and peptides can be found conjoined in nature, e.g., in glycopeptides, the aim of this review is the radical redesign of peptide structures using carbohydrates, particularly monosaccharides and cyclic oligosaccharides, to produce novel peptides, peptidomimetics, and abiotic proteins. These hybrid molecules, chimeras, have properties arising largely from the combination of structural characteristics of carbohydrates with the functional group diversity of peptides. This field includes de novo designed synthetic glycopeptides, sugar (carbohydrate) amino acids, carbohydrate scaffolds for nonpeptidal peptidomimetics of cyclic peptides, cyclodextrin functionalized peptides, and carboproteins, i.e., carbohydrate-based proteinmimetics. These successful applications demonstrate the general utility of carbohydrates in peptide and protein architecture.
Jensen
Knud J
KJ
Department of Natural Sciences, Section for Bioorganic Chemistry, KVL, 1871 Frederiksberg C, Denmark. kjj@kvl.dk
Brask
Jesper
J
D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry; D002240:Carbohydrate Sequence; D002241:Carbohydrates / Q000737:chemistry*; D015195:Drug Design; D006020:Glycopeptides / Q000138:chemical synthesis / Q000737:chemistry; D008968:Molecular Conformation; D018716:Molecular Mimicry; D015394:Molecular Structure; D009844:Oligosaccharides / Q000138:chemical synthesis / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry; D011506:Proteins / Q000737:chemistry* / Q000235:genetics; D011994:Recombinant Proteins / Q000737:chemistry; D013004:Somatostatin / Q000138:chemical synthesis / Q000737:chemistry; D013400:Sugar Acids / Q000138:chemical synthesis / Q000737:chemistry; D013698:Templates, Genetic
D000596:Amino Acids; D002241:Carbohydrates; D006020:Glycopeptides; D009844:Oligosaccharides; D010455:Peptides; D010456:Peptides, Cyclic; D011506:Proteins; D011994:Recombinant Proteins; D013400:Sugar Acids; D013004:Somatostatin