[Primary malignant schwannoma of the uterine cervix: a malignant tumor with unusual behaviour. A case report].
Malignant tumors of peripheral nerves (MPNST) represent approximately 5-10% of all soft tissue sarcomas and usually are in relationship with a major nerve. Primary cervical malignant Schwannomas are very rare neural sheat tumors that, grossly and clinically, are misdiagnosed for other more frequent lesions of the uterine cervix. We report a case of primary cervical malignant Schwannoma in a 27 years old female with atypical bleeding. The lesion is characterized by densely packed spindle cells with nuclear atypia and high mitotic rate. Immuno-histochemical stains are positive for vimentin and S-100 but negative for HMB-45, keratins, desmin and actin. After 34 months the patient is disease free. To our knowledge, this is the seventh case described.
Di Giovannantonio
L
L
Istituto di Anatomia Patologica, P.O. "SS. Annunziata", Chieti, Dipartimento di Oncologia e Neuroscienze, Università "G. d'Annunzio", Chieti-Pescara.
Bellocci
R
R
Zappacosta
R
R
Zappacosta
B
B
Castrataro
A
A
Liberatore
M
M
Liberati
M
M
Angelucci
D
D
D000328:Adult; D005260:Female; D006801:Humans; D009442:Neurilemmoma / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000473:pathology*