title: [A case of renal pelvic squamous cell carcinoma accompanied with humoral hypercalcemia of malignancy (HHM)].
abstract: A 78-year-old male was urgently admitted to our hospital because of consciousness disturbance. Laboratory data showed marked hypercalcemia (17.0 mg/dl), hypophosphatemia, low intact PTH level, high PTH relating peptide (PTHrP) level, normal osteocalcin and normal 1-25(OH)2D level. Computed tomography revealed a right renal tumor with extracapsular extension. Bone scintigram appeared normal. We performed right nephrectomy under the diagnosis of right renal tumor. Pathological diagnosis was poorly differentiated squamous cell carcinoma (SCC) of the right pelvis. Immunohistochemical study of the resected specimen for PTHrP was positive. Therefore, we diagnosed it as renal pelvic SCC with humoral hypercalcemia of malignancy (HHM). After nephrectomy, serum calcium returned to normal, but 5 months after nephrectomy, local recurrence appeared and serum calcium was re-elevated. She died 7 months after nephrectomy.
authors.affiliation: The Department of Urology, Sasebo City General Hospital.
authors.forename: Masataka
authors.initials: M
authors.lastname: Furukawa
authors.forename: Shohei
authors.initials: S
authors.lastname: Tohbu
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Matsuo
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Hayashida
authors.forename: Kohsuke
authors.initials: K
authors.lastname: Takehara
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tsuda
authors.forename: Kanenori
authors.initials: K
authors.lastname: Maeda
authors.forename: Shotaro
authors.initials: S
authors.lastname: Iwasaki
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Saito
authors.forename: Keisuke
authors.initials: K
authors.lastname: Iwasaki
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nakashima
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000150:complications*; D006801:Humans; D006934:Hypercalcemia / Q000150:complications*; D007680:Kidney Neoplasms / Q000150:complications*; D007682:Kidney Pelvis; D008297:Male; D044162:Parathyroid Hormone-Related Protein / Q000097:blood
chemical_list: C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein