[The electrophysiological study and implantable cardioverter defibrillator therapy for the patients with Brugada syndrome].
OBJECTIVE
Clinical observation of electrophysiological study and implantable cardioverter defibrillator (ICD) therapy in patients with Brugada syndrome.


METHODS
Ten patients (all male) with Brugada wave (spontaneous or propafenone test positive in ECG) underwent electrophysiological study (EPS). The mean age was (41 +/- 10) years. They had no structural heart disease with echocardiogram and the angiogram work-up. The ICD implanted in the patients with EPS-induced ventricular fibrillation in those who were available.


RESULTS
Three patients had the history of familial sudden cardiac death (SCD). Four patients had repeated syncope episodes, two of them had documented ventricular fibrillation during syncope episodes. The AH and HV intervals were 50 - 124 (86 +/- 21) ms and 41 - 84 (58 +/- 15) ms. The ventricular fibrillation was induced in four patients with syncope and atrioventricular reentry tachycardia in one patient with palpitation. Three patients had spontaneous or inducible atrial fibrillation. The ICD implanted in three patients with inducible ventricular fibrillation. Due to economic issue, one patient without ICD implantation had got SCD during follow-up. The patient with atrioventricular reentry tachycardia underwent a successful left atrioventricular accessory pathway ablation.


CONCLUSIONS
The Brugada patients with syncope and high rate of inducible ventricular fibrillation in EPS are the high risk population for SCD, in whom ICD should implant promptly to prevent SCD.
Shan
Qi-jun
QJ
Department of Cardiology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Yang
Bing
B
Chen
Ming-long
ML
Zou
Jian-gang
JG
Xu
Dong-jie
DJ
Chen
Chun
C
Li
Ku-lin
KL
Zhu
Pin-jun
PJ
Wang
Xiao-bing
XB
Cao
Ke-jiang
KJ
D000328:Adult; D053840:Brugada Syndrome / Q000503:physiopathology* / Q000628:therapy*; D016757:Death, Sudden, Cardiac / Q000517:prevention & control; D017147:Defibrillators, Implantable; D004594:Electrophysiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D014693:Ventricular Fibrillation / Q000628:therapy