Design and synthesis of new bis-pyridinium oxime reactivators for acetylcholinesterase inhibited by organophosphorous nerve agents.
New bis-pyridinium oxime reactivators connected with a CH(2)CH(2)OCH(2)CH(2) linker between two pyridinium rings were designed and synthesized. In the test of their potency to reactivate AChE inhibited by cyclosarin, the bis-pyridinium oxime 6b achieved reactivation potency higher than 10% at the lower concentration 10(-4)M.
Kim
Tae-Hyuk
TH
Medicinal Science Division, Korea Research Institute of Chemical Technology, Yusong, Taejon.
Kuca
Kamil
K
Jun
Daniel
D
Jung
Young-Sik
YS
D000110:Acetylcholinesterase / Q000187:drug effects / Q000378:metabolism*; D002801:Cholinesterase Reactivators / Q000138:chemical synthesis* / Q000494:pharmacology; D010755:Organophosphates / Q000494:pharmacology*; D011726:Pyridinium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*
D002801:Cholinesterase Reactivators; D010755:Organophosphates; D011726:Pyridinium Compounds; D000110:Acetylcholinesterase