Mapping quantitative trait loci in humans: achievements and limitations.
Recent advances in statistical methods and genomic technologies have ushered in a new era in mapping clinically important quantitative traits. However, many refinements and novel statistical approaches are required to enable greater successes in this mapping. The possible impact of recent findings pertaining to the structure of the human genome on efforts to map quantitative traits is yet unclear.
Majumder
Partha P
PP
Human Genetics Unit, Indian Statistical Institute, Kolkata, India. ppm@isical.ac.in
Ghosh
Saurabh
S
D015894:Genome, Human; D006801:Humans; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D020161:Physical Chromosome Mapping; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable