[Antiviral action of membranotropic compounds modified by adamantane and norbornene pharmacophores exerted on different HIV-1 strains].
The anti-HIV activity of new membranotropic compounds, i.e. of the polycarboxylate matrix and of its derivatives modified by adamantane and norbonene, was studied in respect of HIV-1 strains, whose tropicity to coreceptors CCR5 and CXCR4 was different, as well as in respect of HIV-1 variants resistant to azidothymidine (AZT) in a continuous culture of human lymphoid cells (MT-4) and in mononuclear cells of peripheral blood from healthy donors. Testing of complex compounds in a culture of infected MT-4 human lymphoid cells showed an effective inhibition of viral reproduction of LAV.04 (CXCR4-tropic variant) and of HIV11(EVK) as well as AZT-resistant variants. The studied pharmacophores-modified compounds displayed, in infection of the primary culture of human mononuclear cells of the HIV-1 R5 and X4 strains, a notable antiviral activity with their HIV efficiency significantly exceeding the one of the original matrix.
Kiseleva
Ia Iu
IaIu
Perminova
N G
NG
liasunova
O A
OA
Timofeev
D I
DI
Serbin
A V
AV
Kas'ian
L I
LI
Egorov
Iu A
IuA
Grebinik
T S
TS
Timofeev
I V
IV
D000218:Adamantane / Q000737:chemistry*; D000812:Anhydrides / Q000737:chemistry*; D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D024882:Drug Resistance, Viral; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D009636:Norbornanes / Q000737:chemistry*
D000812:Anhydrides; D019380:Anti-HIV Agents; D009636:Norbornanes; C085227:norbornene anhydride; D000218:Adamantane