title: Essential oils of commonly used plants as inhibitors of peroxynitrite-induced tyrosine nitration.
abstract: The essential oils obtained from fifteen relevant and commonly used plants belonging to Cruciferae, Lamiaceae, Lauraceae, Apiaceae, and Zingiberaceae were screened using an in vitro model of peroxynitrite-induced tyrosine nitration. Almost complete inhibition of 3-nitrotyrosine formation (91% at 300 microg/ml) was achieved only with the essential oil obtained from the leaves of Laurus nobilis. 1,8-Cineol, accounting for a 50% of this essential oil, which resulted as inactive in this model, thus evidencing a major role for the minor volatile compounds present in the leaves.
authors.affiliation: Dipartimento di Chimica Bioorganica e Biofarmacia, Università di Pisa, via Bonanno 33, 56126 Pisa, Italy. chersil@farm.unipi.it
authors.forename: Silvio
authors.initials: S
authors.lastname: Chericoni
authors.forename: Josè M
authors.initials: JM
authors.lastname: Prieto
authors.forename: Patrizia
authors.initials: P
authors.lastname: Iacopini
authors.forename: Ivano
authors.initials: I
authors.lastname: Morelli
mesh_terms: D006801:Humans; D027442:Laurus; D009566:Nitrates / Q000737:chemistry; D030421:Peroxynitrous Acid / Q000737:chemistry; D008517:Phytotherapy; D018515:Plant Leaves; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D014443:Tyrosine / Q000737:chemistry*
chemical_list: D009566:Nitrates; D010938:Plant Oils; D030421:Peroxynitrous Acid; D014443:Tyrosine