Angioedema acute hypersensitivity reaction to injectable hyaluronic acid.
BACKGROUND
Injectable hyaluronic acid was introduced to European markets in 1996 and has demonstrated a high safety profile. We describe the first reported case of angioedema-type hypersensitivity following injection of the upper lip with non-animal-stabilized hyaluronic acid (NASHA) gel.


OBJECTIVE
To report a case and discuss a potential mechanism for and treatment of angioedema-type hypersensitivity following injection with NASHA gel into the upper lip.


METHODS
Not applicable.


RESULTS
Not applicable.


CONCLUSIONS
Although injectable hyaluronic acid has a high safety profile, this reaction is dramatic. Treatments and potential mechanisms are discussed.
Leonhardt
Janie M
JM
Center for Dermatologic Surgery, Cooper University Hospital, Marlton, New Jersey 08053, USA.
Lawrence
Naomi
N
Narins
Rhoda S
RS
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000009:adverse effects*; D000799:Angioedema / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D005260:Female; D005782:Gels; D006560:Herpes Labialis / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000009:adverse effects*; D015552:Injections, Intralesional; D008875:Middle Aged
D000276:Adjuvants, Immunologic; D005782:Gels; D006820:Hyaluronic Acid