Microtensile testing of collagen fibril for cardiovascular tissue engineering.
As a candidate scaffold material for cardiac tissue engineering, Type I collagen material shows different mechanical properties due to the differences in the structural features such as orientation of fibril alignment and the environmental factors such as ultraviolet (UV) irradiation. In this article one-dimensional tensile stress tests were performed with the use of a nanoscale tensile tester on four groups of Type I collagen samples that were differentiated in terms of fibril orientation and/or UV irradiation. The collagen surface structure was studied with the use of an atomic force microscope (AFM). Effects of fibril orientation and UV irradiation on their mechanical properties were investigated. The mechanical properties and deformation mechanisms are discussed in conjunction with collagen structure, fibril orientation, and dispersion of the generated crosslinking by UV irradiation.
Wang
Xinnan
X
Department of Mechanical Engineering, University of South Carolina, 300 Main Street, Columbia, SC 29208, USA.
Li
Xiaodong
X
Yost
Michael J
MJ
D001696:Biomechanical Phenomena; D002318:Cardiovascular Diseases / Q000628:therapy*; D003094:Collagen / Q000737:chemistry*; D005260:Female; D006801:Humans; D008297:Male; D018625:Microscopy, Atomic Force; D013718:Tensile Strength; D023822:Tissue Engineering; D014466:Ultraviolet Rays
D003094:Collagen