[Preliminary clinical observation on effect of soduim ferulate in treating diabetic nephropathy].
OBJECTIVE
To investigate the effect of sodium ferulate (SF) on diabetic nephropathy (DN).


METHODS
Forty-eight DN patients of early stage and 54 DN patients of clinical stage were randomly divided into two groups, the conventional treatment group and the SF treatment group. Indexes, including urinary albumin excretion rate (UAER), serum endothelin (ET), blood urea nitrogen (BUN), serum creatinine (Scr) and fasting blood glucose (FBG) were observed.


RESULTS
The levels of UAER, BUN and ET were decreased in all DN patients, either early stage or clinical stage, after treated with SF for 4 weeks (P < 0.05, P < 0.01), but changed insignificantly in those treated with conventional treatment.


CONCLUSIONS
SF can decrease the levels of UAER and BUN in DN patients, the mechanism may relate with the decreasing of ET production and antagonizing to the binding of ET with its receptors.
Zheng
Feng-ming
FM
Department of Endocrinology, The Second Hospital Affiliated to Medical College of Zhejiang University, Hangzhou. ljjzfm0@sohu.com
Ren
Yue-zhong
YZ
Zhao
Tong-feng
TF
D000328:Adult; D000368:Aged; D003373:Coumaric Acids / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D003928:Diabetic Nephropathies / Q000188:drug therapy*; D065128:Endothelin Receptor Antagonists; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy
D003373:Coumaric Acids; D065128:Endothelin Receptor Antagonists; C004999:ferulic acid