Role of the isoprenoid pathway in ras transforming activity, cytoskeleton organization, cell proliferation and apoptosis.
The isoprenoid pathway, by its end-products lipids, has an important role in the control of ras transforming activity, cytoskeleton organization, cell proliferation and apoptosis. In particular, prenylation, a post-translational addition of farnesol and geranylgeraniol, is an important event for the biological activity of many proteins that play critical roles in signal transduction and cytoskeletal regulation, as well as in cell proliferation and apoptosis. We have been interested in studying the: (a) regulation of the isoprenoid pathway in the processing of cellular transformation induced by the K-ras oncogene, (b) role of the isoprenoid pathway in the control of cell proliferation and apoptosis, (c) role of the isoprenoid pathway in the control of cytoskeleton organization and (d) control of Rab expression by the isoprenoid pathway.
Bifulco
Maurizio
M
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, via Ponte Don Melillo 84084, Fisciano, Salerno, Italy. maubiful@unina.it
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D003599:Cytoskeleton / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology; D011905:Genes, ras / Q000502:physiology*; D008954:Models, Biological; D051381:Rats; D015398:Signal Transduction / Q000502:physiology*; D013729:Terpenes / Q000378:metabolism*; D020691:rab GTP-Binding Proteins / Q000378:metabolism
D013729:Terpenes; D020691:rab GTP-Binding Proteins