title: Palestinian infantile visceral leishmaniasis caused by a genetic variant of Leishmania infantum belonging to a new zymodeme.
abstract: The parasites causing a Palestinian case of infantile visceral leishmaniasis (IVL) and those from four dogs from the Jenin District were identified serologically, biochemically and molecular biologically as Leishmania infantum, showing dogs act as a reservoir. The strain from the human case was distinct because of its unique 200-bp kDNA-polymerase chain reaction (PCR) component in its restriction fragment length polymorphism (RFLP) profile after digestion with the endonuclease RsaI, and by the electrophoretic mobility of its malate dehydrogenase (MDH(140)), designating it the reference strain of a new zymodeme of L. infantum, MON-281.
authors.affiliation: Department of Parasitology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
authors.forename: Khaldoun A
authors.initials: KA
authors.lastname: Bader
authors.forename: Lionel F
authors.initials: LF
authors.lastname: Schnur
authors.forename: Abedelmajeed
authors.initials: A
authors.lastname: Nasereddin
authors.forename: Francine
authors.initials: F
authors.lastname: Pratlong
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Dedet
authors.forename: Loay
authors.initials: L
authors.lastname: Shaheen
authors.forename: Obaida
authors.initials: O
authors.lastname: Yousef
authors.forename: Charles L
authors.initials: CL
authors.lastname: Greenblatt
mesh_terms: D000818:Animals; D002675:Child, Preschool; D016054:DNA, Protozoan / Q000032:analysis; D004197:Disease Reservoirs / Q000662:veterinary*; D004283:Dog Diseases / Q000469:parasitology*; D004285:Dogs; D006801:Humans; D018314:Leishmania infantum / Q000235:genetics*; D007898:Leishmaniasis, Visceral / Q000235:genetics / Q000469:parasitology*; D008297:Male; D016133:Polymerase Chain Reaction / Q000379:methods; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D016054:DNA, Protozoan