title: Current controversies in oral lichen planus: report of an international consensus meeting. Part 1. Viral infections and etiopathogenesis.
abstract: Despite recent advances in understanding the immunopathogenesis of oral lichen planus (LP), the initial triggers of lesion formation and the essential pathogenic pathways are unknown. It is therefore not surprising that the clinical management of oral LP poses considerable difficulties to the dermatologist and the oral physician. A consensus meeting was held in France in March 2003 to discuss the most controversial aspects of oral LP. Part 1 of the meeting report focuses on (1) the relationship between oral LP and viral infection with special emphasis on hepatitis C virus (HCV), and (2) oral LP pathogenesis, in particular the immune mechanisms resulting in lymphocyte infiltration and keratinocyte apoptosis. Part 2 focuses on patient management and therapeutic approaches and includes discussion on malignant transformation of oral LP.
authors.affiliation: Department of Medicine, Surgery, and Dentistry, University of Milan, Italy. giovanni.lodi@unimi.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: Lodi
authors.forename: Crispian
authors.initials: C
authors.lastname: Scully
authors.forename: Marco
authors.initials: M
authors.lastname: Carrozzo
authors.forename: Mark
authors.initials: M
authors.lastname: Griffiths
authors.forename: Philip B
authors.initials: PB
authors.lastname: Sugerman
authors.forename: Kobkan
authors.initials: K
authors.lastname: Thongprasom
mesh_terms: D017209:Apoptosis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D018925:Chemokines / Q000096:biosynthesis; D006086:Graft vs Host Disease / Q000150:complications; D016174:Hepacivirus / Q000472:pathogenicity; D006564:Herpesviridae / Q000472:pathogenicity; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism; D017676:Lichen Planus, Oral / Q000276:immunology* / Q000821:virology*; D008407:Mast Cells / Q000276:immunology; D027383:Papillomaviridae / Q000472:pathogenicity; D014777:Virus Diseases / Q000150:complications
chemical_list: D018925:Chemokines