title: Histologic study of furcation perforations treated with MTA or Super EBA in dogs' teeth.
abstract: OBJECTIVE
  The aim of this study was to investigate the histologic response to MTA or Super EBA when used for the repair of furcation perforations in dogs' teeth.
  
  
  METHODS
  Ninety mandibular premolar and molar teeth of 9 mongrel dogs were used in this study. The teeth were divided into 3 groups. Seventy-two teeth were repaired with either MTA or Super EBA (36 each), and 18 teeth were not repaired and used as negative controls. All groups were histologically examined at 1 month, 3 months, and 6 months after treatment. Histologic evaluation was done with regard to inflammation and type of healing.
  
  
  RESULTS
  The Super EBA group showed moderate inflammation in 1 month; the inflammation decreased over time, but most of specimens showed inflammatory reaction from mild to severe at the end of 6 months. The perforation area was filled by connective tissue in specimens in which no inflammation was seen. In the MTA group, mild inflammation was seen in 1 month, it decreased in 3 months, and no inflammation was detected in 6 months. New cementum formation was taken in place in 4 specimens in 1 month, in 8 specimens in 3 months, and in all specimens in 6 months.
  
  
  CONCLUSIONS
  MTA showed less inflammation than Super EBA. MTA specimens showed healing with new cementum formation in the perforation area, whereas Super EBA specimens in which no inflammation was seen showed connective tissue healing.
authors.affiliation: Department of Endodontics, Faculty of Dentistry, Marmara University, Istanbul, Turkey.
authors.forename: Tahsin
authors.initials: T
authors.lastname: Yildirim
authors.forename: Nimet
authors.initials: N
authors.lastname: Gençoğlu
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Firat
authors.forename: Cem
authors.initials: C
authors.lastname: Perk
authors.forename: Ozlem
authors.initials: O
authors.lastname: Guzel
mesh_terms: D017607:Aluminum Compounds / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D017610:Calcium Compounds / Q000627:therapeutic use / Q000633:toxicity; D017220:Dentin-Bonding Agents / Q000627:therapeutic use / Q000633:toxicity; D004285:Dogs; D004338:Drug Combinations; D007249:Inflammation / Q000139:chemically induced; D010087:Oxides / Q000627:therapeutic use / Q000633:toxicity; D010486:Periapical Tissue / Q000187:drug effects; D012387:Root Canal Filling Materials / Q000627:therapeutic use* / Q000633:toxicity; D018915:Root Canal Preparation / Q000009:adverse effects; D017640:Silicates / Q000627:therapeutic use / Q000633:toxicity; D018677:Tooth Injuries / Q000209:etiology / Q000628:therapy*; D014092:Tooth Root / Q000293:injuries*
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D017220:Dentin-Bonding Agents; D004338:Drug Combinations; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate; C084074:Super EBA