Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task.
The effect of a sulbutiamine chronic treatment on memory was studied in rats with a spatial delayed-non-match-to-sample (DNMTS) task in a radial maze and a two trial object recognition task. After completion of training in the DNMTS task, animals were subjected for 9 weeks to daily injections of either saline or sulbutiamine (12.5 or 25 mg/kg). Sulbutiamine did not modify memory in the DNMTS task but improved it in the object recognition task. Dizocilpine, impaired both acquisition and retention of the DNMTS task in the saline-treated group, but not in the two sulbutiamine-treated groups, suggesting that sulbutiamine may counteract the amnesia induced by a blockade of the N-methyl-D-aspartate glutamate receptors. Taken together, these results are in favor of a beneficial effect of sulbutiamine on working and episodic memory.
Bizot
Jean-Charles
JC
Key-Obs S.A., Centre d'Innovation, 16 rue Léonard de Vinci, 45074 Orléans Cedex 2, France. jcbizot@key-obs.com
Herpin
Alexandre
A
Pothion
Stéphanie
S
Pirot
Sylvain
S
Trovero
Fabrice
F
Ollat
Hélène
H
D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy*; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D016291:Dizocilpine Maleate; D004305:Dose-Response Relationship, Drug; D018782:Maze Learning / Q000187:drug effects; D008570:Memory, Short-Term / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000187:drug effects*; D021641:Recognition, Psychology / Q000187:drug effects*; D013028:Space Perception / Q000187:drug effects*; D013831:Thiamine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D013997:Time Factors
C031331:sulbutiamine; D016291:Dizocilpine Maleate; D013831:Thiamine