title: Efficacy of tibolone and transdermal estrogen therapy on psychological symptoms in women following surgical menopause.
abstract: OBJECTIVE
  This study investigated the efficacy of tibolone and transdermal estradiol therapy on menopausal and psychological symptoms in women following surgical menopause.
  
  
  METHODS
  Seventy-five women who had undergone surgical menopause were randomized to a 6-month double-blind interventional study treatment with oral 2.5 mg/day tibolone, transdermal 3.9 mg/week estradiol or oral placebo. The patients were assessed using Kupperman's Scale, Hamilton Depression Rating Scale (HDRS) and Hamilton Anxiety Rating Scale (HARS) before and at the end of the 6 months of treatment.
  
  
  RESULTS
  Sixty-five subjects completed the study: 23 on tibolone, 21 on transdermal estradiol and 21 on placebo. At the end of the 6 months of therapy, highly significant improvements in menopausal symptoms, depression and anxiety scores were observed in both groups (tibolone and transdermal estradiol groups) as compared with baseline values (p<0.001). However, in the placebo group, there were no significant differences on changes from baseline to the end of treatment (p>0.05).
  
  
  CONCLUSIONS
  These results suggest that tibolone and transdermal estradiol therapy significantly improve menopausal and psychological symptoms in women following surgical menopause.
authors.affiliation: 1st Obstetrics and Gynecology Clinic, Sişli Etfal Training and Research Hospital, Istanbul, Turkey. alpbaksu@yahoo.com
authors.forename: A
authors.initials: A
authors.lastname: Baksu
authors.forename: B
authors.initials: B
authors.lastname: Ayas
authors.forename: S
authors.initials: S
authors.lastname: Citak
authors.forename: A
authors.initials: A
authors.lastname: Kalan
authors.forename: B
authors.initials: B
authors.lastname: Baksu
authors.forename: N
authors.initials: N
authors.lastname: Goker
mesh_terms: D000279:Administration, Cutaneous; D001007:Anxiety / Q000188:drug therapy; D003863:Depression / Q000188:drug therapy; D004311:Double-Blind Method; D045166:Estradiol Congeners / Q000008:administration & dosage / Q000627:therapeutic use*; D020847:Estrogen Receptor Modulators / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008593:Menopause / Q000187:drug effects* / Q000523:psychology*; D009652:Norpregnenes / Q000627:therapeutic use*; D011446:Prospective Studies
chemical_list: D045166:Estradiol Congeners; D020847:Estrogen Receptor Modulators; D009652:Norpregnenes; C027385:tibolone