title: Phase II metabolites of etofesalamide in filamentous fungi.
abstract: OBJECTIVE
  To study phase II metabolites of etofesalamide in filamentous fungi.
  
  
  METHODS
  Seven fungi were screened to transform etofesalamide. The metabolites of etofesalamide were assayed using liquid chromatography coupled to mass spectrometry. The major metabolite was subject to enzymatic hydrolysis to confirm its structure.
  
  
  RESULTS
  Etofesalamide was converted into two phase II metabolites: glucoside and riboside conjugates. Glucoside conjugate was the major product with a yield greater than 90%; no phase I metabolites were detected.
  
  
  CONCLUSIONS
  Glucoside and riboside conjugations of etofesalamide in filamentous fungi differ from the phase II metabolism of glucuronidation in mammals.
authors.affiliation: Department of Pharmaceutical Microbiology, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Hai-Hua
authors.initials: HH
authors.lastname: Huang
authors.forename: Gui-Lei
authors.initials: GL
authors.lastname: Ma
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Sun
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.forename: Da-Fang
authors.initials: DF
authors.lastname: Zhong
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000378:metabolism*; D001230:Aspergillus / Q000378:metabolism; D001549:Benzamides / Q000378:metabolism*; D001711:Biotransformation; D002853:Chromatography, Liquid; D020093:Cunninghamella / Q000145:classification / Q000378:metabolism*; D005960:Glucosides / Q000378:metabolism; D013058:Mass Spectrometry; D009089:Mucor / Q000378:metabolism; D010407:Penicillium / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001549:Benzamides; D005960:Glucosides; C512377:etofesalamide