Gastric cytoprotective activity of ilicic aldehyde: structure-activity relationships.
A series of sesquiterpene compounds possessing both eudesmane and eremophilane skeletons were tested as gastric cytoprotective agents on male Wistar rats. The presence of an alpha,beta-unsaturated aldehyde on the C-7 side chain together with a hydroxyl group at C-4 is the requirement for the observed antiulcerogenic activity. In an attempt to establish new molecular structural requirements for this gastric cytoprotective activity, a structure-activity study was performed.
Donadel
Osvaldo J
OJ
INTEQUI-CONICET, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, 5700 San Luis, Argentina. odonadel@unsl.edu.ar
Guerreiro
Eduardo
E
María
Alejandra O
AO
Wendel
Graciela
G
Enriz
Ricardo D
RD
Giordano
Oscar S
OS
Tonn
Carlos E
CE
D000818:Animals; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000494:pharmacology*; D041981:Gastrointestinal Tract / Q000166:cytology / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology*; D013276:Stomach Ulcer / Q000188:drug therapy; D013329:Structure-Activity Relationship
D000897:Anti-Ulcer Agents; D012717:Sesquiterpenes; C456084:ilicic aldehyde