Impurity analysis of retinoic acid samples.
The structure of an impurity contained in samples of all trans-retinoic acid was established by means of NMR and MS spectra, and confirmed by X-ray diffraction analysis. The chemical structure of the impurity 2 was found to be strictly correlated to the synthetic procedure employed for the preparation of the retinoic acid samples. Single crystal analysis allowed us to characterise the molecular conformation and the crystal structure of 2.
Allegrone
Gianna
G
Dip. Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Univ. Degli Studi del Piemonte Orientale A.Avogadro, Novara, Italy.
Brenna
Elisabetta
E
Fronza
Giovanni
G
Fuganti
Claudio
C
Giovenzana
Tommaso
T
Malpezzi
Luciana
L
Barlocchi
Enrico
E
Pellegatta
Cesare
C
D018360:Crystallography, X-Ray / Q000379:methods; D004340:Drug Contamination; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014212:Tretinoin / Q000032:analysis* / Q000737:chemistry
D014212:Tretinoin