Electrostatic control of aromatic stacking interactions.
A supramolecular approach has been used to investigate the free energies of intermolecular aromatic stacking interactions. Chemical double mutant cycles have been used to measure the effect of a range of substituents on face-to-face stacking interactions with phenyl and pentafluorophenyl rings. Electrostatic effects dominate the trends in interaction energy.
Cockroft
Scott L
SL
Centre for Chemical Biology, Department of Chemistry, Krebs Institute for Biomolecular Science, University of Sheffield, Sheffield S3 7HF, U.K.
Hunter
Christopher A
CA
Lawson
Kevin R
KR
Perkins
Julie
J
Urch
Christopher J
CJ
D004247:DNA / Q000737:chemistry; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D006860:Hydrogen Bonding; D008958:Models, Molecular; D055672:Static Electricity; D013816:Thermodynamics
D006841:Hydrocarbons, Aromatic; D004247:DNA