Metabolic changes in rat striatum following convulsive seizures.
Generalized convulsive seizures increase glucose utilization within the brain but their impact on metabolism is not well known. The striatum receives excitatory input from widespread sources in the brain and could potentially reflect energy depletion in the brain resulting from generalized seizures. We utilized multiprobe microdialysis in freely moving rats subjected to maximal electroshock to simultaneously measure glucose, lactate, and pyruvate levels in the interstitial space within striatum and in peripheral subcutaneous tissue. A brief convulsive seizure was associated with marked changes in striatal and peripheral metabolism during the post-ictal state that lasted up to 1 h. There were significant central and peripheral elevations of glucose, pyruvate, and lactate, reflecting increased glucose metabolism. Interestingly, the lactate-to-pyruvate ratio increased significantly in the periphery but remained unchanged in the striatum. Thus, there appears to be brain mechanisms that maintain adequate energy sources and prevent anaerobic shift during the post-ictal state.
Darbin
Olivier
O
Department of Neurology, Southern Illinois University School of Medicine, PO Box 19637, Springfield, IL 62794-9637, USA.
Risso
Jean Jacque
JJ
Carre
Emily
E
Lonjon
Michel
M
Naritoku
Dean K
DK
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D004597:Electroshock; D004734:Energy Metabolism / Q000502:physiology*; D004827:Epilepsy / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D006019:Glycolysis / Q000502:physiology; D019344:Lactic Acid / Q000378:metabolism; D008297:Male; D017551:Microdialysis; D019289:Pyruvic Acid / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D019344:Lactic Acid; D019289:Pyruvic Acid; D005947:Glucose