A case of osteoclast-like giant cell tumor of the pancreas with ductal adenocarcinoma: histopathological, immunohistochemical, ultrastructural and molecular biological studies.
Osteoclast-like giant cell tumor of the pancreas is a very rare neoplasm, of which the histiogenesis remains controversial. A 63-yr-old woman was hospitalized for evaluation of epigastric pain. An abdominal computerized tomography revealed the presence of a large cystic mass, arising from the tail of pancreas. A distal pancreatectomy with splenectomy was performed. Histologically, the tumor was composed of mononuclear stromal cells intermingled with osteclast-like giant cells. In addition, there was a small area of moderately to well differentiated ductal adenocarcinoma. The final pathologic diagnosis was osteoclast-like giant cell tumor of the pancreas with ductal adenocarcinoma. Here, we describe the histopathological, immunohistochemical, ultrastructural and molecular biological findings of this tumor with review of the literature pertaining to this condition.
Joo
Young-Eun
YE
Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea. mareejb@netian.com
Heo
Tag
T
Park
Chang-Hwan
CH
Lee
Wan-Sik
WS
Kim
Hyun-Soo
HS
Kim
Jung-Chul
JC
Koh
Yang-Seok
YS
Choi
Sung-Kyu
SK
Cho
Chol-Kyoon
CK
Rew
Jong-Sun
JS
Kim
Sei-Jong
SJ
D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D021441:Carcinoma, Pancreatic Ductal / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D003937:Diagnosis, Differential; D005260:Female; D005870:Giant Cell Tumors / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008854:Microscopy, Electron; D008875:Middle Aged; D018396:Mucin-1 / Q000032:analysis; D010010:Osteoclasts / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D014746:Vimentin / Q000032:analysis; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D007633:Keratins; D018396:Mucin-1; D018809:Proliferating Cell Nuclear Antigen; D014746:Vimentin; C067980:CD68 antigen, human; D000097382:CD68 Molecule