title: Synthesis of cationic beta-vinyl substituted meso-tetraphenylporphyrins and their in vitro activity against herpes simplex virus type 1.
abstract: An easy route to cationic beta-vinyl substituted meso-tetraphenylporphyrin derivatives is described. Two novel compounds were tested in vitro for their antiviral photoactivity against herpes simplex virus type 1. One of these compounds exhibited a significant activity, reaching 99% of virus inactivation after 15 min of photoactivation.
authors.affiliation: Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
authors.forename: Eduarda M P
authors.initials: EM
authors.lastname: Silva
authors.forename: Francesca
authors.initials: F
authors.lastname: Giuntini
authors.forename: Maria A F
authors.initials: MA
authors.lastname: Faustino
authors.forename: João P C
authors.initials: JP
authors.lastname: Tomé
authors.forename: Maria G P M S
authors.initials: MG
authors.lastname: Neves
authors.forename: Augusto C
authors.initials: AC
authors.lastname: Tomé
authors.forename: Artur M S
authors.initials: AM
authors.lastname: Silva
authors.forename: Maria G
authors.initials: MG
authors.lastname: Santana-Marques
authors.forename: António J
authors.initials: AJ
authors.lastname: Ferrer-Correia
authors.forename: José A S
authors.initials: JA
authors.lastname: Cavaleiro
authors.forename: Maria F
authors.initials: MF
authors.lastname: Caeiro
authors.forename: Ricardo R
authors.initials: RR
authors.lastname: Duarte
authors.forename: Sabina A P
authors.initials: SA
authors.lastname: Tavares
authors.forename: Inês N
authors.initials: IN
authors.lastname: Pegado
authors.forename: Bruno
authors.initials: B
authors.lastname: d'Almeida
authors.forename: António P A
authors.initials: AP
authors.lastname: De Matos
authors.forename: Maria L
authors.initials: ML
authors.lastname: Valdeira
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000528:radiation effects; D002412:Cations / Q000737:chemistry; D049109:Cell Proliferation / Q000187:drug effects; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010777:Photochemistry; D011166:Porphyrins / Q000138:chemical synthesis / Q000494:pharmacology / Q000528:radiation effects; D013329:Structure-Activity Relationship; D014466:Ultraviolet Rays; D014709:Vero Cells; D014753:Vinyl Compounds / Q000138:chemical synthesis / Q000494:pharmacology / Q000528:radiation effects
chemical_list: D000998:Antiviral Agents; D002412:Cations; D011166:Porphyrins; D014753:Vinyl Compounds; C409084:tetraphenylporphyrin