title: Proteomics-on-a-chip: the challenge to couple lab-on-a-chip unit operations.
abstract: This review describes a vision of a proteomics-on-a-chip device to separate, detect and identify the proteome. It guides the reader towards a development strategy, avoiding some of the pitfalls. It also describes the current state-of-the-art developments in proteomic analysis including available technologies, current market issues, the elements of an envisaged proteomics-on-a-chip device, the required microfabrication processes and the integration of the elements into one device. Address-flow microfluidics is a tool for connecting separation and detection platforms. The final section contains an expert opinion on the recommended development strategies, benefits of proteomics-on-a-chip in the life sciences and the anticipated market.
authors.affiliation: Biochip Group, Faculty of Science and Technology, University of Twente, PO Box 217, 7500 AE Enschede, The Netherlands. r.b.m.schasfoort@utwente.nl
authors.forename: Richard B M
authors.initials: RB
authors.lastname: Schasfoort
mesh_terms: D015195:Drug Design; D006801:Humans; D046208:Microchip Analytical Procedures / Q000379:methods* / Q000639:trends; D044085:Microfluidics; D011506:Proteins / Q000032:analysis / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D040901:Proteomics / Q000379:methods* / Q000639:trends; D049490:Systems Biology
chemical_list: D011506:Proteins