title: Immune functions in crustaceans: lessons from flies.
abstract: In recent years insects, notably Drosophila, have emerged as a popular model for studying immune responses to bacterial and fungal pathogens. Due to the availability of the complete genome sequence, genome-wide scans of immune responses have been performed using microarray analyses. These analyses have revealed the presence of two major pathways: Toll and Imd. Each pathway consists of four steps: (i) recognition through pattern recognition receptors; (ii) modulation by serine proteases; (iii) signal transduction leading to translocation of transcription factors and (iv) humoral and cellular responses. We have compared the information from insects with those currently available in crustaceans, and have identified commonalities and differences. Remarkably, in both insects and crustaceans, little is known about their anti-viral responses. Future research will have to focus on these anti-viral immune responses ultimately to control viral diseases, which are at present a major threat to culturing penaeid shrimp.
authors.affiliation: Cell Biology and Immunology Group, Wageningen Institute of Animal Sciences, Wageningen University, Wageningen, The Netherlands. rene.stet@wur.nl
authors.forename: R J M
authors.initials: RJ
authors.lastname: Stet
authors.forename: J A J
authors.initials: JA
authors.lastname: Arts
mesh_terms: D000818:Animals; D003445:Crustacea / Q000235:genetics / Q000276:immunology*; D004330:Drosophila / Q000235:genetics / Q000276:immunology*; D029721:Drosophila Proteins / Q000276:immunology* / Q000378:metabolism; D023281:Genomics / Q000379:methods; D007109:Immunity / Q000276:immunology*; D046228:Microarray Analysis / Q000379:methods; D011956:Receptors, Cell Surface / Q000276:immunology* / Q000378:metabolism; D012697:Serine Endopeptidases / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology*; D051193:Toll-Like Receptors
chemical_list: D029721:Drosophila Proteins; D011956:Receptors, Cell Surface; C068721:Tl protein, Drosophila; D051193:Toll-Like Receptors; C439909:imd protein, Drosophila; D012697:Serine Endopeptidases