Immunomodulation after allogeneic bone marrow transplantation by CD4+CD25+ regulatory T cells.
Graft-versus-host disease is a major complication after allogeneic bone marrow transplantation (BMT) caused by donor T cells. Immunosuppression mediated by CD4(+)CD25(+) regulatory T cells has been shown to ameliorate such pathogenic immune responses in animal models. Here, we summarize recent findings from experimental and clinical studies and propose a model for peripheral tolerance induction after BMT.
Hoffmann
Petra
P
Institute of Immunology, University Hospital Regensburg, University of Regensburg, Germany.
Boeld
Tina J
TJ
Piseshka
Biserka
B
Edinger
Matthias
M
D000818:Animals; D016026:Bone Marrow Transplantation / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology*; D006086:Graft vs Host Disease / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D015375:Receptors, Interleukin-2 / Q000502:physiology*
D015375:Receptors, Interleukin-2