title: Sevoflurane versus propofol for induction of anaesthesia for electroconvulsive therapy: a randomized crossover trial.
abstract: Propofol is often used to induce anaesthesia for electroconvulsive therapy. Some patients who receive propofol have fits of poor quality or inadequate duration despite increasing electroconvulsive therapy doses. Sevoflurane has been reported to exhibit pro-convulsant properties in some "at-risk" patients during anaesthesia for other procedures. The purpose of this study was to perform a randomized crossover trial in patients undergoing electroconvulsive therapy, comparing the effects on seizure parameters of propofol versus sevoflurane induction. Patients were randomly allocated to receive either sevoflurane or propofol for their first treatment. In the subsequent treatment the alternative agent was used. Patients in both treatment groups exhibited equally good fits, with those in the sevoflurane group having slightly better morphology, which is the most subjective of the parameters measured. The sevoflurane administrations were associated with slightly higher pulse rates and blood pressures. Sevoflurane provides a suitable alternative to propofol for anaesthesia in patients undergoing electroconvulsive therapy, although the slightly greater pulse rate rise and blood pressure rise should be considered in patients with ischaemic heart disease.
authors.affiliation: Department of Anaesthesia, Frankston Hospital, Melbourne, Victoria.
authors.forename: T
authors.initials: T
authors.lastname: Loughnan
authors.forename: G
authors.initials: G
authors.lastname: McKenzie
authors.forename: S
authors.initials: S
authors.lastname: Leong
mesh_terms: D000758:Anesthesia; D000777:Anesthetics / Q000494:pharmacology; D018685:Anesthetics, Inhalation / Q000494:pharmacology; D018592:Cross-Over Studies; D004565:Electroconvulsive Therapy; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology; D008875:Middle Aged; D015742:Propofol / Q000494:pharmacology; D012640:Seizures / Q000209:etiology; D000077149:Sevoflurane; D013997:Time Factors
chemical_list: D000777:Anesthetics; D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D015742:Propofol