Epithelial cell signaling responses to enterohemorrhagic Escherichia coli infection.
Enterohemorrhagic Escherichia coli, including the serotype O157:H7 that is most commonly identified with human disease, cause both sporadic cases and outbreaks of non-bloody diarrhea and hemorrhagic colitis. In about 10% of infected subjects, the hemolytic uremic syndrome (hemolytic anemic, thrombocytopenia, and acute renal failure) develops, likely as a consequence of systemic spread of bacterial-derived toxins variously referred to as Shiga-like toxin, Shiga toxin, and Verotoxin. Increasing evidence points to a complex interplay between bacterial products--for example, adhesins and toxins--and host signal transduction pathways in mediating responses to infection. Identification of critical signaling pathways could result in the development of novel strategies for intervention to both prevent and treat this microbial infection in humans.
Ceponis
Peter J M
PJ
Research Institute, Hospital for Sick Children, Deparment of Laboratory Medicine, University of Toronto, Ontario M5G 1X8, Canada.
Riff
Jason D
JD
Sherman
Philip M
PM
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D004847:Epithelial Cells / Q000382:microbiology* / Q000502:physiology; D004927:Escherichia coli Infections / Q000382:microbiology*; D019453:Escherichia coli O157 / Q000472:pathogenicity*; D006471:Gastrointestinal Hemorrhage / Q000382:microbiology*; D006801:Humans; D050794:STAT1 Transcription Factor / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
D050794:STAT1 Transcription Factor; C494079:STAT1 protein, human