Structure-activity relationships of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists.
SAR studies of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists resulted in potent compounds. The best compound from the series had a binding affinity of 2 nM.
Guo
Zhiqiang
Z
Department of Medicinal Chemistry, Neurocrine Biosciences, Inc., 12790 El Camino Real, San Diego, CA 92130, USA. zguo@neurocrine.com
Wu
Dongpei
D
Zhu
Yun-Fei
YF
Tucci
Fabio C
FC
Regan
Collin F
CF
Rowbottom
Martin W
MW
Struthers
R Scott
RS
Xie
Qiu
Q
Reijmers
Shelby
S
Sullivan
Susan K
SK
Sai
Yang
Y
Chen
Chen
C
D004353:Drug Evaluation, Preclinical; D006801:Humans; D015394:Molecular Structure; D011966:Receptors, LHRH / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D014227:Triazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D011966:Receptors, LHRH; D014227:Triazines