title: Comparison of histidine-tryptophan ketoglutarate and University of Wisconsin solutions as primary preservation in renal allografts undergoing pulsatile perfusion.
abstract: BACKGROUND
  University of Wisconsin (UW) solution is the standard preservation solution for organ transplantation. Histidine-tryptophan ketogluatarate (HTK) solution has been used increasingly for kidney, pancreas, and liver transplantation. This study compared HTK and UW used during kidney procurement with subsequent pulsatile perfusion.
  
  
  METHODS
  Between January and October 2003, 91 deceased renal and simultaneous kidney pancreas transplants were performed (UW, n = 41, and HTK, n = 50). There were no differences with regard to donor and recipient demographics or cold ischemia.
  
  
  RESULTS
  Delayed graft function occurred in 3 (7%) of UW and 4 (8%) of HTK-preserved kidneys (P = NS). There were no significant differences between patient or graft survival. There was an anticipated difference between total preservative volumes used (HTK: 4.1 +/- 1.0 vs UW: 3.0 +/- 0.5; P < .005).
  
  
  CONCLUSIONS
  UW and HTK appear to have similar efficacy in kidney preservation with pulsatile perfusion. HTK preservation solution can be used safely in conjunction with pulsatile preservation for cold storage of renal allografts.
authors.affiliation: Department of Surgery, Indiana University School of Medicine, 550 N. University Boulevard #4258, Indianapolis, IN 46202, USA.
authors.forename: A
authors.initials: A
authors.lastname: Agarwal
authors.forename: W C
authors.initials: WC
authors.lastname: Goggins
authors.forename: M D
authors.initials: MD
authors.lastname: Pescovitz
authors.forename: M L
authors.initials: ML
authors.lastname: Milgrom
authors.forename: P
authors.initials: P
authors.lastname: Murdock
authors.forename: J A
authors.initials: JA
authors.lastname: Fridell
mesh_terms: D000241:Adenosine; D000328:Adult; D000493:Allopurinol; D005260:Female; D005947:Glucose; D005978:Glutathione; D006801:Humans; D007328:Insulin; D007668:Kidney; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D008353:Mannitol; D008875:Middle Aged; D019188:Organ Preservation Solutions; D016035:Pancreas Transplantation; D010477:Perfusion / Q000379:methods; D011189:Potassium Chloride; D011343:Procaine; D011887:Raffinose; D012449:Safety; D014019:Tissue Donors / Q000706:statistics & numerical data; D014184:Transplantation, Homologous
chemical_list: C039984:Bretschneider cardioplegic solution; D007328:Insulin; D019188:Organ Preservation Solutions; C055206:University of Wisconsin-lactobionate solution; D008353:Mannitol; D011343:Procaine; D000493:Allopurinol; D011189:Potassium Chloride; D005978:Glutathione; D005947:Glucose; D000241:Adenosine; D011887:Raffinose