title: Localized hand-foot syndrome after intra-arterial hepatic chemotherapy with floxuridine: a clinical case.
abstract: Hand-foot syndrome is a toxic effect of some chemotherapy agents such as 5-fluorouracil (5-FU), capecitabine and liposomal doxorubicin. The symptoms and signs are localized erythema and paresthesia. Floxuridine (FUDR) is an analogue of 5-FU, used for arterial hepatic infusion in patients affected by liver metastases from colorectal cancer. A patient who was treated for colorectal cancer with liver metastases underwent locoregional chemotherapy with FUDR and systemic chemotherapy with FOLFOX4. After three cycles he developed severe painful dermatitis of the right leg. Abdominal X-ray showed displacement of the catheter to the right common iliac artery. Treatment was discontinued and the patient had a rapid recovery.
authors.affiliation: Medical Oncology Department, Igea Hospital, Milan, Italy. regina.claudia@libero.it
authors.forename: Claudia
authors.initials: C
authors.lastname: Bareggi
authors.forename: Daniela
authors.initials: D
authors.lastname: Paleari
authors.forename: Marina Chiara
authors.initials: MC
authors.lastname: Garassino
authors.forename: Monica
authors.initials: M
authors.lastname: Mora
authors.forename: Silvia
authors.initials: S
authors.lastname: Salamina
authors.forename: Monica
authors.initials: M
authors.lastname: Senecione
authors.forename: Antonio
authors.initials: A
authors.lastname: Ghidini
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Pancera
mesh_terms: D000328:Adult; D002404:Catheterization; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology; D003872:Dermatitis / Q000209:etiology* / Q000473:pathology*; D005467:Floxuridine / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives / Q000627:therapeutic use*; D005528:Foot / Q000473:pathology*; D006225:Hand / Q000473:pathology*; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D013577:Syndrome; D014962:X-Ray Film
chemical_list: D005467:Floxuridine