Validation of predictors of intraprocedural stent thrombosis in the drug-eluting stent era.
Although predictors of acute intraprocedural stent thrombosis (IPST) in the drug-eluting stent era have been proposed, external validation is lacking. We thus analyzed the occurrence of IPST in the RECIPE study and found that, among 1,320 patients who underwent drug-eluting stent implantation, IPST occurred in 6 (0.5%), with in-hospital major adverse events in 4 (67%). IPST was predicted by number and total length of implanted stents, baseline minimal lumen diameter, and, in a pooled analysis that incorporated values from the present study and a previous study, use of elective glycoprotein IIb/IIIa inhibitors. Such results may provide useful information to guide prevention of this complication.
Biondi-Zoccai
Giuseppe G L
GG
St. Raffaele Hospital, Milan, Italy.
Sangiorgi
Giuseppe M
GM
Chieffo
Alaide
A
Vittori
Guido
G
Falchetti
Elena
E
Margheri
Massimo
M
Barbagallo
Rossella
R
Tamburino
Corrado
C
Remigi
Enrico
E
Briguori
Carlo
C
Iakovou
Ioannis
I
Agostoni
Pierfrancesco
P
Tsagalou
Elephteria
E
Melzi
Gloria
G
Michev
Iassen
I
Airoldi
Flavio
F
Montorfano
Matteo
M
Carlino
Mauro
M
Colombo
Antonio
A
D000208:Acute Disease; D000925:Anticoagulants / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D019917:Blood Vessel Prosthesis Implantation / Q000295:instrumentation*; D000077144:Clopidogrel; D020099:Coated Materials, Biocompatible; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000601:surgery; D003328:Coronary Thrombosis / Q000175:diagnosis* / Q000517:prevention & control; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007431:Intraoperative Complications; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011237:Predictive Value of Tests; D011725:Pyridines / Q000627:therapeutic use; D012189:Retrospective Studies; D015607:Stents; D015912:Thrombolytic Therapy; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D016896:Treatment Outcome
D000925:Anticoagulants; D000972:Antineoplastic Agents, Phytogenic; D020099:Coated Materials, Biocompatible; D010975:Platelet Aggregation Inhibitors; D011725:Pyridines; C446540:thienopyridine; D006493:Heparin; D000077144:Clopidogrel; D013988:Ticlopidine; D017239:Paclitaxel