Defects in ankyrin-based cellular pathways in metazoan physiology.
Ankyrins are a ubiquitously expressed family of membrane-adaptor proteins found in most vertebrate tissues. Since the first ankyrin polypeptide was identified over 25 years ago, studies in humans, mice, and lower organisms have implicated critical roles for ankyrins in normal metazoan physiology. This review will provide an overview of the ankyrin family and highlight seminal findings in the field which have linked dysfunction in ankyrin-based pathways with defects in metazoan physiology and human disease.
Mohler
Peter J
PJ
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. peter.j.mohler@vanderbilt.edu
Bennett
Vann
V
D000818:Animals; D017487:Ankyrins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D000013:Congenital Abnormalities; D005057:Eukaryotic Cells / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D017434:Protein Structure, Tertiary
D017487:Ankyrins