title: [Neurotoxic encephalopathy caused by neuroleptics and lithium].
abstract: Treatment of psychiatric patients often necessitates overlapping neuroleptic medication. We report a 60-year-old woman suffering from a schizoaffective disorder who received temporarily three neuroleptics, together with lithium. She developed neurotoxic encephalopathy with symptoms of a malignant neuroleptic syndrome. It is unclear if irreversible brain damage will remain. We recommend frequent electroencephalographic controls for early detection of neurotoxicity.
authors.affiliation: Abteilung Psychosoziale Medizin, Universitätsspital Zürich, Schweiz. evelina.lambreva@usz.ch
authors.forename: E
authors.initials: E
authors.lastname: Lambreva
authors.forename: M
authors.initials: M
authors.lastname: Vecellio
authors.forename: H G
authors.initials: HG
authors.lastname: Wieser
authors.forename: C
authors.initials: C
authors.lastname: Buddeberg
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D004338:Drug Combinations; D004569:Electroencephalography / Q000379:methods; D005260:Female; D006801:Humans; D008094:Lithium / Q000009:adverse effects* / Q000627:therapeutic use*; D008875:Middle Aged; D020258:Neurotoxicity Syndromes / Q000175:diagnosis* / Q000209:etiology* / Q000517:prevention & control; D011379:Prognosis; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents; D004338:Drug Combinations; D008094:Lithium