Duodenal gangliocytic paraganglioma: a radiological-pathological correlation.
Duodenal gangliocytic paraganglioma is a rare tumor that characteristically occurs in the second portion of the duodenum and typically presents with gastrointestinal bleeding. Gangliocytic paragangliomas have a characteristic triphasic microscopic appearance with epithelioid cells, spindle cells, and ganglion cells, resulting in a complex histology with features of paraganglioma, carcinoid, and ganglioneuroma. Duodenal gangliocytic paragangliomas have an excellent prognosis after surgical resection but metastatic spread to regional lymph nodes and recurrence may rarely occur. We report a case of duodenal gangliocytic paraganglioma and discuss the radiological and pathological differential diagnosis of this rare entity.
Plaza
Jose Antonio
JA
Department of Pathology, The Ohio State University Medical Center, Columbus, OH 43210, USA.
Vitellas
Kenneth
K
Marsh
William L
WL
D014408:Biomarkers, Tumor / Q000378:metabolism; D002276:Carcinoid Tumor / Q000175:diagnosis; D003937:Diagnosis, Differential; D018572:Disease-Free Survival; D004379:Duodenal Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D005260:Female; D005729:Ganglioneuroma / Q000175:diagnosis; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D018317:Nerve Sheath Neoplasms / Q000175:diagnosis; D010235:Paraganglioma / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D009418:S100 Proteins / Q000378:metabolism; D018235:Smooth Muscle Tumor / Q000175:diagnosis; D017154:Stromal Cells / Q000473:pathology; D014057:Tomography, X-Ray Computed
D014408:Biomarkers, Tumor; D009418:S100 Proteins