title: Hyperbaric oxygen as an adjunctive treatment for zygomycosis.
abstract: Zygomycosis is a rare but emerging mycosis. Because of the sub-optimal efficacy of the standard antifungal treatment for this disease, hyperbaric oxygen (HBO) has been used occasionally as an adjunctive therapeutic modality. A review of 28 published cases of zygomycosis indicates that adjunctive HBO may be beneficial in diabetic patients (94% survival), whereas its benefit in the small group of patients with haematological malignancies or bone marrow transplants is doubtful (33% survival; p 0.02). Prolonged courses of HBO were associated with a higher survival (100% survival; p 0.003). Additional studies are required to assess the optimal timing and dose for HBO treatment.
authors.forename: B V
authors.initials: BV
authors.lastname: John
authors.forename: G
authors.initials: G
authors.lastname: Chamilos
authors.forename: D P
authors.initials: DP
authors.lastname: Kontoyiannis
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D048909:Diabetes Complications / Q000628:therapy; D019337:Hematologic Neoplasms / Q000150:complications / Q000382:microbiology; D006801:Humans; D006931:Hyperbaric Oxygenation; D007223:Infant; D008297:Male; D008875:Middle Aged; D009090:Mucorales; D016896:Treatment Outcome; D020096:Zygomycosis / Q000150:complications / Q000628:therapy*