title: Effects of short-term propofol administration on pancreatic enzymes and triglyceride levels in children.
abstract: This prospective, clinical trial evaluated the effects of short-term propofol administration on triglyceride levels and serum pancreatic enzymes in children undergoing sedation for magnetic resonance imaging. Laboratory parameters of 40 children, mean age (SD; range) 67 (66; 4-178) months undergoing short-term sedation were assessed before and 4 h after having received propofol. Mean (SD) propofol loading dose was 2.2 (1.1) mg.kg(-1) followed by continuous propofol infusion of 6.9 (0.9) mg.kg(-1).h(-1). Serum lipase levels (p = 0.035) and serum triglyceride levels (p = 0.003) were raised significantly after propofol administration but remained within normal limits. No significant changes in serum pancreatic-amylase levels were seen (p = 0.127). In two (5%) children, pancreatic enzymes and in four (10%) children triglyceride levels were raised above normal limits; however, no child showed clinical symptoms of pancreatitis. We conclude that even short-term propofol administration with standard doses of propofol may have a significant effect on serum triglyceride and pancreatic enzyme levels in children.
authors.affiliation: Department of Paediatric Haematology and Oncology, University Children's Hospital, Kirrbergerstrasse, 66421 Homburg/Saar, Germany. kisgot@uniklinik-saarland.de
authors.forename: S
authors.initials: S
authors.lastname: Gottschling
authors.forename: S
authors.initials: S
authors.lastname: Meyer
authors.forename: T
authors.initials: T
authors.lastname: Krenn
authors.forename: S
authors.initials: S
authors.lastname: Kleinschmidt
authors.forename: H
authors.initials: H
authors.lastname: Reinhard
authors.forename: N
authors.initials: N
authors.lastname: Graf
authors.forename: G M
authors.initials: GM
authors.lastname: Shamdeen
mesh_terms: D000293:Adolescent; D000681:Amylases / Q000097:blood; D018686:Anesthetics, Intravenous / Q000494:pharmacology; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D016292:Procedural Sedation / Q000379:methods; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D007223:Infant; D008049:Lipase / Q000097:blood; D008279:Magnetic Resonance Imaging; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000201:enzymology*; D015742:Propofol / Q000494:pharmacology*; D011446:Prospective Studies; D014280:Triglycerides / Q000097:blood*
chemical_list: D018686:Anesthetics, Intravenous; D006993:Hypnotics and Sedatives; D014280:Triglycerides; D008049:Lipase; D000681:Amylases; D015742:Propofol