Relation between estradiol and negative symptoms in men with schizophrenia.
The authors tested the hypothesis that estradiol would be associated with negative symptoms in 30 male schizophrenia inpatients. Medications were switched from typical to atypical antipsychotics. Estradiol concentrations were inversely correlated with negative symptoms significantly before the switch and at a trend level of significance after the switch. Changes in negative symptoms were positively correlated with those in estradiol concentrations at a trend level of significance. Estradiol could be a biological marker for negative symptoms even in male schizophrenia patients.
Kaneda
Y
Y
Department of Psychiatry, Tokushima University Hospital, Japan. kaneday-tsh@umin.ac.jp
Ohmori
T
T
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D015415:Biomarkers; D004958:Estradiol / Q000097:blood; D006801:Humans; D007297:Inpatients; D008297:Male; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy; D012565:Schizophrenic Psychology
D014150:Antipsychotic Agents; D015415:Biomarkers; D004958:Estradiol