title: High-dose cyclophosphamide as an effective therapy for a patient with refractory multiple myeloma relapsing after autologous stem cell transplantation.
abstract: Alkylating agents are often used to treat patients with multiple myeloma (MM). However, it is not common for high-dose cyclophosphamide (CPM) therapy to be used as a treatment for MM. Herein, we report a case of refractory MM associated with hypercalcemia. We decided to give her high-dose CPM. After this treatment, the serum calcium level decreased and the tumor mass in the iliac bone was reduced. This therapy is potentially useful for patients with refractory MM.
authors.affiliation: Hematology Division, Niigata University Postgraduate School of Medical and Dental Sciences, Japan.
authors.forename: Kumiko
authors.initials: K
authors.lastname: Yagisawa
authors.forename: Akiko
authors.initials: A
authors.lastname: Aiba
authors.forename: Akihito
authors.initials: A
authors.lastname: Momoi
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Tsukada
authors.forename: Koji
authors.initials: K
authors.lastname: Nikkuni
authors.forename: Sadao
authors.initials: S
authors.lastname: Aoki
authors.forename: Yoshifusa
authors.initials: Y
authors.lastname: Aizawa
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage*; D001853:Bone Marrow / Q000473:pathology; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007085:Ilium / Q000000981:diagnostic imaging; D008875:Middle Aged; D009101:Multiple Myeloma / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D012886:Skull / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D014182:Transplantation, Autologous
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide