Successful reduced-intensity stem cell transplantation (RIST) for a patient with malignant lymphoma and an ileostomy.
A 56-year-old man was admitted for treatment of non-Hodgkin's lymphoma (NHL). He had undergone a partial small bowel and colon resection and had ileostomy due to bowel perforation induced by chemotherapy. After the operation, his disease status was in partial remission (PR), and reduced-intensity allogeneic stem cell transplantation (RIST) was therefore performed for further improvement of disease status. The conditioning regimen consisted of fludarabine and busulfan. Graft-versus-host disease (GVHD) prophylaxis was performed using cyclosporin and short-term methotrexate. The occurrence of serious infection during the period of neutropenia was prevented by the administration of amphotericin B, fluconazole and acyclovir. This case report provides important information on the appropriate strategy for treating patients who have ileostomy.
Toubai
Tomomi
T
Department of Hematology and Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Tanaka
Junji
J
Ota
Shuichi
S
Mori
Akio
A
Ibata
Makoto
M
Shono
Yusuke
Y
Mashiko
Shinobu
S
Sugita
Junichi
J
Miura
Yoko
Y
Kato
Naoko
N
Umehara
Shintaro
S
Kahata
Kaoru
K
Toyoshima
Nobuyasu
N
Asaka
Masahiro
M
Imamura
Masahiro
M
D000970:Antineoplastic Agents / Q000009:adverse effects; D001706:Biopsy; D003106:Colon / Q000000981:diagnostic imaging / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D007081:Ileostomy; D007416:Intestinal Perforation / Q000139:chemically induced / Q000175:diagnosis / Q000601:surgery*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D008297:Male; D008482:Mediastinum / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D049268:Positron-Emission Tomography; D012422:Rupture, Spontaneous; D033581:Stem Cell Transplantation / Q000379:methods*; D014057:Tomography, X-Ray Computed
D000970:Antineoplastic Agents