title: AnovArray: a set of SAS macros for the analysis of variance of gene expression data.
abstract: BACKGROUND
  Analysis of variance is a powerful approach to identify differentially expressed genes in a complex experimental design for microarray and macroarray data. The advantage of the anova model is the possibility to evaluate multiple sources of variation in an experiment.
  
  
  RESULTS
  AnovArray is a package implementing ANOVA for gene expression data using SAS statistical software. The originality of the package is 1) to quantify the different sources of variation on all genes together, 2) to provide a quality control of the model, 3) to propose two models for a gene's variance estimation and to perform a correction for multiple comparisons.
  
  
  CONCLUSIONS
  AnovArray is freely available at http://www-mig.jouy.inra.fr/stat/AnovArray and requires only SAS statistical software.
authors.affiliation: Unité Mathématique, Informatique et Génome, INRA, 78352 Jouy-en-Josas, France. Christelle.Hennequet-Antier@jouy.inra.fr
authors.forename: Christelle
authors.initials: C
authors.lastname: Hennequet-Antier
authors.forename: Hélène
authors.initials: H
authors.lastname: Chiapello
authors.forename: Karine
authors.initials: K
authors.lastname: Piot
authors.forename: Séverine
authors.initials: S
authors.lastname: Degrelle
authors.forename: Isabelle
authors.initials: I
authors.lastname: Hue
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Renard
authors.forename: François
authors.initials: F
authors.lastname: Rodolphe
authors.forename: Stéphane
authors.initials: S
authors.lastname: Robin
mesh_terms: D000465:Algorithms; D000704:Analysis of Variance; D000818:Animals; D002417:Cattle; D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D015870:Gene Expression; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D015723:Gene Library; D020407:Internet; D015233:Models, Statistical; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D011381:Programming Languages; D011786:Quality Control; D015203:Reproducibility of Results; D018401:Sample Size; D012680:Sensitivity and Specificity; D017422:Sequence Analysis, DNA; D012984:Software; D014018:Tissue Distribution