title: From Poisson distribution to interleukins.
abstract: Abstract In the mid-1970s, Ivan Lefkovits and co-workers introduced limiting dilution analysis of T and B cells as a method to quantify antigen-specific T and B cells. In this study, I describe how my co-operation with Ivan on the subject led not only to heated discussions on the validity of the approach but also to the identification of interleukin-2 as T-cell-derived factor, capable of replacing T-cell help required for the activation of B cells.
authors.affiliation: Sanquin Research Department of Autoimmune Diseases, Amsterdam, the Netherlands. l.aarden@sanquin.nl
authors.forename: L
authors.initials: L
authors.lastname: Aarden
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques / Q000266:history* / Q000706:statistics & numerical data; D003604:Czechoslovakia; D049673:History, 20th Century; D006801:Humans; D007376:Interleukin-2 / Q000266:history*; D016012:Poisson Distribution
chemical_list: D007376:Interleukin-2