Brain-behavior relations during motor processing in chronic tic and habit disorder.
OBJECTIVE
This study examined electrophysiological indices of preparation (readiness potential, RP) and execution (movement-associated potential, MAP) during automated and controlled reaction time (RT) in 13 chronic tic disorder, 17 habit disorder, and 14 control participants.


BACKGROUND
Both tic and habit disorders are hypothesized to involve states of heightened activation, which could impede initiation and the control of complex motor actions.


METHODS
The electrophysiological signal was recorded from 4 electrodes (Fz, C3, C4, Pz) during a fixed 4-second foreperiod reaction time task.


RESULTS
During automated responses, controls showed a shorter RP peak onset, and during controlled responses a longer MAP peak onset, compared with both clinical groups. The controls were the only group who showed a consistent linear relationship between RP and RT.


CONCLUSIONS
Patients with chronic tic as well as habit disorder may not modulate cortical activation optimally in planning and executing both automated and controlled responses.
O'Connor
Kieron P
KP
Hôpital Louis-H Lafontaine and Centre de Recherche Fernand-Seguin, Département de Psychiatrie, Université de Montréal, Montréal, Québec, Canada. kieron.oconnor@crfs.umontreal.ca
Lavoie
Marc E
ME
Robert
Manon
M
Stip
Emmanuel
E
Borgeat
François
F
D000328:Adult; D001921:Brain / Q000502:physiology*; D016022:Case-Control Studies; D004594:Electrophysiology; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology*; D011930:Reaction Time; D013981:Tic Disorders / Q000503:physiopathology*