Tuberculosis due to resistant Haarlem strain, Tunisia.
Multidrug-resistant tuberculosis was diagnosed in 21 HIV-negative, nonhospitalized male patients residing in northern Tunisia. A detailed investigation showed accelerated transmission of a Mycobacterium tuberculosis clone of the Haarlem type in 90% of all patients. This finding highlights the epidemic potential of this prevalent genotype.
Mardassi
Helmi
H
Institut Pasteur de Tunis, Tunis-Belvédère, Tunisia. helmi.merdassi@pasteur.rns.tn
Namouchi
Amine
A
Haltiti
Raja
R
Zarrouk
Mourad
M
Mhenni
Besma
B
Karboul
Anis
A
Khabouchi
Neila
N
Gey van Pittius
Nico C
NC
Streicher
Elizabeth M
EM
Rauzier
Jean
J
Gicquel
Brigette
B
Dellagi
Koussay
K
D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000494:pharmacology*; D015373:Bacterial Typing Techniques; D004251:DNA Transposable Elements; D024881:Drug Resistance, Bacterial / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000187:drug effects* / Q000235:genetics; D009841:Oligonucleotides / Q000032:analysis; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D015995:Prevalence; D018088:Tuberculosis, Multidrug-Resistant / Q000453:epidemiology* / Q000382:microbiology / Q000635:transmission; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology* / Q000382:microbiology / Q000635:transmission; D014416:Tunisia / Q000453:epidemiology
D000995:Antitubercular Agents; D004251:DNA Transposable Elements; D009841:Oligonucleotides