title: Demonstration of a high level of parasite population homology by quantification of Plasmodium falciparum alleles in matched peripheral, placental, and umbilical cord blood samples.
abstract: Plasmodium falciparum msp-1 and msp-2 genes were quantified by fragment analysis in matched placental, peripheral, and cord blood samples. In the three compartments, the multiplicity of infection values were similar, and parasite populations only partially overlapped, as reported. However, identical alleles represented 80 to 95% of the overall parasite populations of each compartment, demonstrating much more homogenous parasite populations than previously thought.
authors.affiliation: Faculté de Phamacie, UR 010, Mother and child Health in the Tropics, Institut de Recherche pour le Développement, 75006 Paris, France.
authors.forename: Sayeh
authors.initials: S
authors.lastname: Jafari-Guemouri
authors.forename: Nicaise Tuikue
authors.initials: NT
authors.lastname: Ndam
authors.forename: Gwladys
authors.initials: G
authors.lastname: Bertin
authors.forename: Emily
authors.initials: E
authors.lastname: Renart
authors.forename: Sokhna
authors.initials: S
authors.lastname: Sow
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Le Hesran
authors.forename: Philippe
authors.initials: P
authors.lastname: Deloron
mesh_terms: D000483:Alleles; D000818:Animals; D000953:Antigens, Protozoan / Q000235:genetics; D001769:Blood / Q000469:parasitology*; D005260:Female; D005312:Fetal Blood / Q000469:parasitology*; D006801:Humans; D007231:Infant, Newborn; D016778:Malaria, Falciparum / Q000469:parasitology*; D020066:Merozoite Surface Protein 1 / Q000235:genetics; D010920:Placenta / Q000469:parasitology*; D010963:Plasmodium falciparum / Q000235:genetics* / Q000302:isolation & purification; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000469:parasitology; D015800:Protozoan Proteins / Q000235:genetics
chemical_list: D000953:Antigens, Protozoan; D020066:Merozoite Surface Protein 1; D015800:Protozoan Proteins; C065974:merozoite surface protein 2, Plasmodium