Novel cytotoxic monotetrahydrofuranic Annonaceous acetogenins from Annona montana.
Four new monotetrahydrofuranic Annonaceous acetogenins, montalicins G (1) and H (2) and monlicins A (3) and B (4), and two new linear acetogenins, (+)-monhexocin (5) and (-)-monhexocin (6), as well as three known compounds, murisolin (7), 4-deoxyannomontacin (8), and muricatacin (9), were isolated from the seeds of Annona montana by high performance liquid chromatographic (HPLC) method. The absolute stereochemical structures of new isolates were elucidated and characterized by spectral and chemical methods. Interestingly, these compounds show special cytotoxicity against human hepatoma cells, Hep G2.
Liaw
Chih-Chuang
CC
Graduate Institute of Natural Products, Kaohsiung Medical University, 100, Shih-Chuan 1st Road, Kaohsiung, Taiwan.
Chang
Fang-Rong
FR
Chen
Shu-Li
SL
Wu
Chin-Chung
CC
Lee
Kuo-Hsiung
KH
Wu
Yang-Chang
YC
D054378:Acetogenins; D031041:Annona / Q000737:chemistry*; D045744:Cell Line, Tumor; D005233:Fatty Alcohols / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000633:toxicity*; D005663:Furans / Q000737:chemistry*; D006801:Humans; D006859:Hydrogen / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000633:toxicity*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
D054378:Acetogenins; D005233:Fatty Alcohols; D005663:Furans; D007783:Lactones; D006859:Hydrogen