GM-CSF gene-transduced tumor vaccines.
GVAX is a GM-CSF gene-transduced tumor vaccine. Expression of the GM-CSF gene within either autologous or allogeneic tumor cell populations has demonstrated evidence of immune stimulation in patients and evidence of antitumor activity particularly in prostate cancer and non-small-cell lung cancer. Results of preclinical studies justify clinical investigation. A summary of clinical results is presented.
Eager
Robert
R
Mary Crowley Medical Research Center/Texas Oncology PA, Dallas, TX 75201, USA.
Nemunaitis
John
J
D019496:Cancer Vaccines / Q000235:genetics*; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000378:metabolism; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006801:Humans; D008545:Melanoma; D014161:Transduction, Genetic; D014407:Tumor Cells, Cultured
D019496:Cancer Vaccines; D016207:Cytokines; D016178:Granulocyte-Macrophage Colony-Stimulating Factor