title: Ovarian mucinous cystadenocarcinoma with mural nodule of anaplastic carcinoma and synchronous cervical squamous carcinoma.
abstract: Solid mural nodule within a mucinous cystic ovarian tumor occurs more often than generally presumed. One especially interesting case involving coincidental cervical carcinoma is presented. A 38-year-old woman underwent exploratory laparotomy for a right ovarian tumor. After ovarian malignancy had been diagnosed from frozen section, the bilateral salpingo-oophorectomy and hysterectomy was performed. The tumor had a unilocular cystic cavity and a mural nodule. The nodule showed undifferentiated carcinomatous features. The immunohistochemical examination revealed atypical cells in the nodule which were positive for cytokeratin, CEA, and vimentine, establishing its anaplastic nature. A synchronous cervical invasive squamous carcinoma was documented. The patient was treated with chemotherapy and radiotherapy. Currently, at 15 postoperative months, she is well and free of disease. The occurrence of ovarian mucinous cystadenocarcinoma with mural nodule of anaplastic carcinoma and cervical squamous cell carcinoma is evidently very uncommon, because we have not found a similar case in the literature.
authors.affiliation: Department of Cytology, General Hospital of Chania, Crete, Greece.
authors.forename: D
authors.initials: D
authors.lastname: Tamiolakis
authors.forename: I
authors.initials: I
authors.lastname: Venizelos
authors.forename: S
authors.initials: S
authors.lastname: Nikolaidou
authors.forename: M
authors.initials: M
authors.lastname: Lambropoulou
authors.forename: S
authors.initials: S
authors.lastname: Bolioti
authors.forename: N
authors.initials: N
authors.lastname: Papadopoulos
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D018282:Cystadenocarcinoma, Mucinous / Q000473:pathology*; D005260:Female; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000473:pathology*