The prenatal multiplier method for prediction of limb length discrepancy.
OBJECTIVE
The purpose of this study was to produce a method of predicting limb length discrepancy in utero.


METHODS
Using available databases, we divided the femoral and tibial lengths at term by the femoral and tibial lengths at each week of gestation for each percentile. The quotients represent coefficients (multipliers) of limb segment growth at each prenatal age.


RESULTS
We found the prenatal multipliers to be independent of race, percentile, and gender from as early as 12 weeks' gestation. The prenatal multipliers are alike for femur and tibia.


CONCLUSIONS
The prenatal multiplier method allows for quick prediction of limb length discrepancy at term and at skeletal maturity from as early as 12 weeks' gestation. Future study is needed to validate this method clinically.
Paley
Jonathan
J
Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, Baltimore, Maryland 21215, USA.
Gelman
Amanda
A
Paley
Dror
D
Herzenberg
John E
JE
D000365:Age Determination by Skeleton; D005260:Female; D005269:Femur / Q000196:embryology; D005865:Gestational Age; D006801:Humans; D017880:Limb Deformities, Congenital / Q000175:diagnosis*; D008433:Mathematics; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D013977:Tibia / Q000196:embryology