[Prospective clinical study on serum immunity in IgG-antibodies positive patients convalescent from severe acute respiratory syndrome].
OBJECTIVE
To investigate the serum immunological characteristics in patients convalescent from severe acute respiratory syndrome (SARS).


METHODS
In the 1 st, 3 rd, 6 th month after their discharge, eg. SARS-IgG, T cell subsets, blood routine, and the blood biochemistry were systemically determined in SARS convalescent patients.


RESULTS
The SARS-antibodies could be used as the diagnostic evidence. During the 6 months after discharge, the titers of SARS-antibodies were high, but they lowered along with passage of time. At the first recheck, the CD4(+) lymphocyte count was lower than normal level in 55.9% of patients, the CD3(+) lymphocyte count was lower than normal level in 31.2% of patients, and the CD8(+) lymphocyte count was lower than normal level in 14.0% of patients. At the second recheck, the levels of T cell subsets recovered to normal level in the most patients.


CONCLUSIONS
T cell subsets, and the number of leukocyte are abnormal in some patients convalescent from SARS. All the indexes examined recover to normal levels half year after discharge. Therefore, it is necessary to follow up the changes in the levels of SARS-antibodies.
Yin
Cheng-hong
CH
Beijing Friendship Hospital Affiliated to Capital University of Medical Sciences, Beijing 100050, China.
Wang
Chao
C
Wen
Yan
Y
Jiang
Li
L
Liu
Ying
Y
Chen
Jiang-hong
JH
Tang
Shu-zhen
SZ
Yue
Mao-xing
MX
He
Zheng-yi
ZY
Zhang
Shu-wen
SW
Wang
Bao-en
BE
D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D045169:Severe Acute Respiratory Syndrome / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology; D055815:Young Adult
D000914:Antibodies, Viral; D007074:Immunoglobulin G