[Role of intracellular signalling pathways in the development of type 1 diabetes].
Type I diabetes develops following an attack of the immune system that destroys the cells secreting insulin. Death of these cells however requires many intracellular mechanisms that are dependent of the insulin-secreting cells themselves. The pivotal role that the insulin-secreting cells play in their own destruction starts to be uncovered, and these new mechanisms are the target for a whole battery of future drugs.
Bonny
Christophe
C
Unité de génétique moléculaire, Service de génétique médicale, CHUV, 1011 Lausanne. christophe.bonny@chuv.hospvd.ch
D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*