Haplotypes Eco47 III-Nsp I sites frequencies on the IDUA gene in Mexican native population.
BACKGROUND
The frequency of haplotypes of Nsp I-Eco47 III sites, at the IDUA (alpha-L iduronidase) gene, in Huichol, Tarahumara and Mestizo Mexican population is reported.


METHODS
Eco47 III and Nsp I intragenic polymorphisms in IDUA gene are studied in three (Mestizo, Huichol and Tarahumara populations) Mexican groups. Data from normal Australian [Hum. Genet. 90 (1992) 327] individuals were considered for comparative analyses.


RESULTS
The genotypes for IDUA Eco47 III and Nsp I sites in Mexicans were in agreement with Hardy-Weinberg equilibrium. Allele frequency distributions for individual sites differed (P < 0.05) except at site B1 in the Huichol group. Haplotype Eco47 III-Nsp I frequency distributions were different in the three Mexican normal groups, and it was also observed when to compared with the normal Australians.


CONCLUSIONS
This characteristic makes the two IDUA polymorphic sites useful for identification purposes, and these polymorphisms could be included in a PCR based battery of DNA markers.
Gallegos-Arreola
M P
MP
División de Medicina Molecular, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico. marthaga@foreigner.class.udg.mx
Sandoval-Ramírez
L
L
Figuera
L E
LE
Arnaud-López
L
L
Rivas
F
F
Mariaud-Schmidt
R P
RP
Zúñiga-González
G M
GM
D000328:Adult; D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics*; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D007068:Iduronidase / Q000235:genetics*; D008800:Mexico / Q000208:ethnology; D012150:Polymorphism, Restriction Fragment Length
C039257:AGCGCT-specific type II deoxyribonucleases; D015252:Deoxyribonucleases, Type II Site-Specific; D007068:Iduronidase