title: Antiviral T cell responses: phalanx or multipronged attack?
abstract: Around 700 BCE, a new military formation called the phalanx was established in ancient Greece: a tight column of heavy infantry carrying long spears, or pikes, used in a single prong of attack. Later, in the battle of Marathon described by Herodotus, the Greeks learned the advantages of multipronged attacks, a strategy still used in modern warfare. Is the immune system similar in its approach to combatting pathogens or tumors?
authors.affiliation: Department of Medicine, Division of Hematology-Oncology, Weill Medical College, Cornell University, New York, NY 10021, USA. dposnett@mail.med.cornell.edu
authors.forename: David N
authors.initials: DN
authors.lastname: Posnett
authors.forename: Manuel E
authors.initials: ME
authors.lastname: Engelhorn
authors.forename: Alan N
authors.initials: AN
authors.lastname: Houghton
mesh_terms: D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D060908:CTLA-4 Antigen; D003586:Cytomegalovirus Infections / Q000276:immunology*; D006801:Humans; D017874:Immediate-Early Proteins / Q000276:immunology; D007111:Immunity, Cellular; D009369:Neoplasms / Q000276:immunology*; D010750:Phosphoproteins / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D014763:Viral Matrix Proteins / Q000276:immunology; D014764:Viral Proteins / Q000276:immunology
chemical_list: D015703:Antigens, CD; D000943:Antigens, Differentiation; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; C088645:IE1 protein, cytomegalovirus; D017874:Immediate-Early Proteins; D010750:Phosphoproteins; D011948:Receptors, Antigen, T-Cell; D014763:Viral Matrix Proteins; D014764:Viral Proteins; C065418:cytomegalovirus matrix protein 65kDa