title: [Distribution and pharmacokinetics of 20S-ginsenoside Rg3 eyeointment in rabbit eye].
abstract: OBJECTIVE
  To determine 20S-ginsenoside Rg3 in various tissues of rabbit eye and evaluate pharmacokinetics following its topical application.
  
  
  METHODS
  45 rabbits were divided into 9 groups. Aqueous humor, cornea and iris-ciliary body were collected at 0.017, 0.033, 0.083, 0.167, 0.5, 1.0, 1.5, 2.0 and 3.0 h following topically applying 1% 20S-ginsenoside Rg3 eyeointment and the concentrations in eye tissues were measured by HPLC.
  
  
  RESULTS
  The pharmacokinetics of 20S-ginsenoside Rg3 in rabbit eye were described by one-compartment model. The peak times in aqueous humor, cornea and iris-ciliary body were 0.42, 0.16 and 0.19 h, and T(1/2) were 0.1, 0.9 and 0.8 h respectively.
  
  
  CONCLUSIONS
  The method of determining 20S-ginsenoside Rg3 in rabbit eyes was established. The pharmacokinetics parameters were determined.
authors.affiliation: Department of Natural Drug Chemistry, Pharmacy Academy of Jilin University, Changchun 130021, China.
authors.forename: Ji-hua
authors.initials: JH
authors.lastname: Liu
authors.forename: Dan
authors.initials: D
authors.lastname: Lu
authors.forename: Jin-ping
authors.initials: JP
authors.lastname: Liu
authors.forename: Ping-ya
authors.initials: PY
authors.lastname: Li
mesh_terms: D000287:Administration, Topical; D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D002924:Ciliary Body / Q000378:metabolism; D003315:Cornea / Q000378:metabolism; D005123:Eye / Q000378:metabolism*; D036145:Ginsenosides / Q000008:administration & dosage / Q000097:blood / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D007498:Iris / Q000378:metabolism; D009824:Ointments; D011817:Rabbits; D014018:Tissue Distribution
chemical_list: D036145:Ginsenosides; D009824:Ointments; C097367:ginsenoside Rg3