Polymorphism of the untranslated regions of the F3/contactin mRNA in the rat nervous system.
F3/contactin is a neural adhesion molecule implicated in various physiological processes. In rat brain tissues, we cloned various mRNA with the same coding region but differing in 3' and 5'UTR. The 3'UTR presents two polyadenylation signals. At the 5' end, we identified two leader exons, multiple transcription initiation sites and splicing events, leading to at least 19 different 5'UTR. The F3/contactin rat gene differs from the mouse gene for two reasons: (1) it contains two additional untranslated exons that are alternatively spliced and (2) it lacks the homologue mouse untranslated exon 0.
Rome
Claire
C
INSERM U378, Institut François Magendie, Université Victor Segalen, Bordeaux, France.
Roullot
Valérie
V
Couillaud
Franck
F
D017398:Alternative Splicing; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000502:physiology*; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics*; D058966:Contactins; D005091:Exons; D051379:Mice; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D016415:Sequence Alignment; D024363:Transcription Initiation Site; D020506:Untranslated Regions / Q000235:genetics*
D015816:Cell Adhesion Molecules, Neuronal; D058966:Contactins; D012333:RNA, Messenger; D020506:Untranslated Regions