title: Human genome -- from pieces to patterns.
abstract: A profile of exon-intron lengths in genes shows a normal distribution. This observation suggests that different genes may have portions of their total exon and/or intron lengths in common. In order to explore the common exon-intron structural patterns that may arise due to common lengths across genes, we compared the exon-intron length patterns of annotated human genes. We discovered 1762278 conserved arrangements of exon-intron length across the otherwise unrelated and diverse genomic landscape. The existence of common exon-intron length patterns across unrelated genes suggests for their role of in gene assemblage and human genome design and architecture.
authors.affiliation: NCSV, MAE, Nanyang Technological University, 639798, Singapore. mmeena@ntu.edu.sg
authors.forename: Meena Kishore
authors.initials: MK
authors.lastname: Sakharkar
authors.forename: Pandjassarame
authors.initials: P
authors.lastname: Kangueane
authors.forename: Bagavathi S
authors.initials: BS
authors.lastname: Perumal
authors.forename: Vincent Tak Kwong
authors.initials: VT
authors.lastname: Chow
authors.forename: Eric
authors.initials: E
authors.lastname: Sorscher
authors.forename: Kishore R
authors.initials: KR
authors.lastname: Sakharkar
authors.forename: Aubrey
authors.initials: A
authors.lastname: Hill
mesh_terms: D001483:Base Sequence; D005091:Exons / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D007438:Introns / Q000235:genetics*; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA