title: Comparison of gemeprost and vaginal misoprostol in first trimester mifepristone-induced abortion.
abstract: BACKGROUND
  The aim of this study was to compare efficacy and side effects of gemeprost and vaginal misoprostol in mifepristone-induced abortions in women up to 63 days of gestation.
  
  
  METHODS
  A retrospective study of 833 consecutive patients admitted for medical termination of first trimester pregnancy was conducted. Four-hundred ten patients received mifepristone 600 mg, followed 48 h later by gemeprost 1 mg (regimen I), and 423 patients received mifepristone 200 mg followed by vaginal misoprostol 800 microg (regimen II). Success rates were evaluated after 2 weeks and after 3 months. The severity of bleeding and side effects (pain, nausea, vomiting and diarrhea) was scored by the patients, and requests for supplementary analgesic treatment were recorded by the attending nurse.
  
  
  RESULTS
  Success rates were 99% in both groups after 2 weeks of follow-up. At 3 months of follow-up, success rates had declined to 94% for regimen I and 96% for regimen II. The frequency of severe pain was higher in regimen I compared to regimen II (72% vs. 60%, p < .001), but the severity of bleeding and gastrointestinal side effects was similar in the two regimens.
  
  
  CONCLUSIONS
  When combined with mifepristone, gemeprost and vaginal misoprostol are equally effective for termination of first trimester abortion, but may be associated with varying intensity of side effects.
authors.affiliation: Department of Obstetrics and Gynecology, Copenhagen University Hospital, 2650 Hvidovre, Copenhagen, Denmark. pernillefsvendsen@hotmail.com
authors.forename: Pernille Fog
authors.initials: PF
authors.lastname: Svendsen
authors.forename: Christina
authors.initials: C
authors.lastname: Rørbye
authors.forename: Thomas
authors.initials: T
authors.lastname: Vejborg
authors.forename: Lisbeth
authors.initials: L
authors.lastname: Nilas
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage* / Q000009:adverse effects; D000028:Abortion, Induced; D000328:Adult; D000527:Alprostadil / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D006063:Chorionic Gonadotropin / Q000097:blood; D005260:Female; D005865:Gestational Age; D006801:Humans; D016595:Misoprostol / Q000008:administration & dosage* / Q000009:adverse effects; D011247:Pregnancy; D012189:Retrospective Studies
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D006063:Chorionic Gonadotropin; D016595:Misoprostol; C021182:gemeprost; D000527:Alprostadil