title: An interventional magnetic resonance imaging technique for the molecular characterization of intraprostatic dynamic contrast enhancement.
abstract: The biological characterization of an individual patient's tumor by noninvasive imaging will have an important role in cancer care and clinical research if the molecular processes that underlie the image data are known. Spatial heterogeneity in the dynamics of magnetic resonance imaging contrast enhancement (DCE-MRI) is hypothesized to reflect variations in tumor angiogenesis. Here we demonstrate the feasibility of precisely colocalizing DCE-MRI data with the genomic and proteomic profiles of underlying biopsy tissue using a novel MRI-guided biopsy technique in a patients with prostate cancer.
authors.affiliation: National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Ménard
authors.forename: Robert C
authors.initials: RC
authors.lastname: Susil
authors.forename: Peter
authors.initials: P
authors.lastname: Choyke
authors.forename: Jonathan
authors.initials: J
authors.lastname: Coleman
authors.forename: Robert
authors.initials: R
authors.lastname: Grubb
authors.forename: Ahmed
authors.initials: A
authors.lastname: Gharib
authors.forename: Axel
authors.initials: A
authors.lastname: Krieger
authors.forename: Peter
authors.initials: P
authors.lastname: Guion
authors.forename: David
authors.initials: D
authors.lastname: Thomasson
authors.forename: Karen
authors.initials: K
authors.lastname: Ullman
authors.forename: Sandeep
authors.initials: S
authors.lastname: Gupta
authors.forename: Virginia
authors.initials: V
authors.lastname: Espina
authors.forename: Lance
authors.initials: L
authors.lastname: Liotta
authors.forename: Emanuel
authors.initials: E
authors.lastname: Petricoin
authors.forename: Gabor
authors.initials: G
authors.lastname: Fitchtinger
authors.forename: Louis L
authors.initials: LL
authors.lastname: Whitcomb
authors.forename: Ergin
authors.initials: E
authors.lastname: Atalar
authors.forename: C Norman
authors.initials: CN
authors.lastname: Coleman
authors.forename: Kevin
authors.initials: K
authors.lastname: Camphausen
mesh_terms: D001706:Biopsy; D003287:Contrast Media; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology*; D012334:RNA, Neoplasm / Q000302:isolation & purification
chemical_list: D003287:Contrast Media; D012334:RNA, Neoplasm