Preparation of adsorbents for the removal of endotoxin.
By using the agar beads as the support, L-lysine as the ligand, three kinds of absorbents with different spacers for removal of endotoxin were prepared. The adsorption capacity of three adsorbents was compared. Among them, Ag3, with L-lysine ligand and hexamethylendiamine as the spacer, was the best in adsorption capacity and was selected for hemoperfusion on rabbits. The results showed the level of endotoxin in endotoxemia rabbit after hemoperfusion was near normal level. The clearance percentage of endotoxin was 73.6%
Hou
Guanghui
G
The State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Institute of Polymer Chemistry, Nankai University, Tianjin, China.
Liu
Tao
T
Wang
Huiyan
H
Fu
Guoqi
G
Yuan
Zhi
Z
Liu
Bin
B
Sun
Lanju
L
Fang
Jie
J
Li
Donghua
D
Qiu
Qi
Q
D000327:Adsorption; D000818:Animals; D019446:Endotoxemia / Q000628:therapy*; D004731:Endotoxins / Q000302:isolation & purification*; D006464:Hemoperfusion / Q000379:methods*; D008024:Ligands; D008239:Lysine; D011817:Rabbits
D004731:Endotoxins; D008024:Ligands; D008239:Lysine