title: No association of the brain-derived neurotrophic factor (BDNF) gene C-270T polymorphism with schizophrenia.
abstract: Brain-derived neurotrophic factor (BDNF) regulates a variety of neuromodulatory processes during development, as well as in adulthood. It has been proposed as a risk factor for schizophrenia. We have investigated a possible association between schizophrenia and the C-270T polymorphism in the brain-derived neurotrophic factor (BDNF) gene in 397 schizophrenic patients and 380 control subjects. The diagnosis of schizophrenia was made for each patient by at least two psychiatrists, using DSM-IV and ICD-10 criteria in structured clinical interviews for DSM-IV Axis I disorders (SCID). No association was found between schizophrenia and the analyzed polymorphism, for either genotype or allele distribution (for genotype: p=0.513, for alleles: p=0.812). Differences were not statistically significant when analyzed separately by sex. For males, the differences for genotype distribution and allele frequency were p=0.078 and p=0.162 respectively and for females: p=0.441 and p=0.315. Thus, our data indicate that variations in the BDNF gene are unlikely to be an important factor in susceptibility to schizophrenia.
authors.affiliation: Laboratory of Psychiatric Genetics, University of Medical Sciences, ul. Szpitalna 27/33, 60-572 Poznan, Poland. alszczep@amp.edu.pl
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Szczepankiewicz
authors.forename: Maria
authors.initials: M
authors.lastname: Skibinska
authors.forename: Piotr M
authors.initials: PM
authors.lastname: Czerski
authors.forename: Paweł
authors.initials: P
authors.lastname: Kapelski
authors.forename: Anna
authors.initials: A
authors.lastname: Leszczynska-Rodziewicz
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Słopien
authors.forename: Monika
authors.initials: M
authors.lastname: Dmitrzak-Weglarz
authors.forename: Filip
authors.initials: F
authors.lastname: Rybakowski
authors.forename: Janusz
authors.initials: J
authors.lastname: Rybakowski
authors.forename: Joanna
authors.initials: J
authors.lastname: Hauser
mesh_terms: D000328:Adult; D000483:Alleles; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D019208:Brain-Derived Neurotrophic Factor