title: Whole body positron emission tomography/computed tomography (PET/CT) tumour staging with integrated PET/CT colonography: technical feasibility and first experiences in patients with colorectal cancer.
abstract: OBJECTIVE
  The aim of this study was to implement an imaging protocol for positron emission tomography/computed tomography (PET/CT) colonography and to combine this protocol with whole body PET/CT tumour staging for a single whole body examination for routine clinical use.
  
  
  METHODS
  A whole body PET/CT protocol for tumour staging and a protocol for PET/CT colonography were integrated into one examination. Fourteen prospective patients with suspected colorectal cancer underwent whole body PET/CT after aqueous bowel distension and pharmacological bowel relaxation. Colonoscopy and histopathology served as the standards of reference in all patients.
  
  
  RESULTS
  The modified PET/CT examination detected all but one lesion in the colon. One additional lesion was detected in a patient with incomplete colonoscopy due to high grade luminal stenosis. One polyp with malignant conversion was identified with the modified PET/CT protocol. PET/CT colonography proved accurate in local lymph node staging and staged nine out of 11 patients correctly. Six additional extracolonic tumour sites were detected based on the whole body staging approach.
  
  
  CONCLUSIONS
  Whole body PET/CT with integrated colonography is technically feasible for whole body staging in patients with colorectal cancer. Based on these initial diagnostic experiences, this integrated protocol may be of substantial benefit in staging patients with colorectal cancer, focusing on patients with incomplete colonoscopy and those with small synchronous bowel lesions.
authors.affiliation: Department of Diagnostic and Interventional Radiology, University Hospital of Essen, Hufelandstrasse 55, 45122 Essen, Germany. patrick.veit@uni-essen.de
authors.forename: P
authors.initials: P
authors.lastname: Veit
authors.forename: C
authors.initials: C
authors.lastname: Kühle
authors.forename: T
authors.initials: T
authors.lastname: Beyer
authors.forename: H
authors.initials: H
authors.lastname: Kuehl
authors.forename: C U
authors.initials: CU
authors.lastname: Herborn
authors.forename: G
authors.initials: G
authors.lastname: Börsch
authors.forename: H
authors.initials: H
authors.lastname: Stergar
authors.forename: J
authors.initials: J
authors.lastname: Barkhausen
authors.forename: A
authors.initials: A
authors.lastname: Bockisch
authors.forename: G
authors.initials: G
authors.lastname: Antoch
mesh_terms: D000368:Aged; D002985:Clinical Protocols; D023881:Colonography, Computed Tomographic / Q000379:methods*; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography / Q000379:methods*; D011446:Prospective Studies; D051598:Whole Body Imaging / Q000379:methods