title: [Pulmonary tuberculosis with cerebellar lesion in a patient after anti-TNF-alpha (infliximab) treatment for rheumatoid arthritis].
abstract: We report a case of pulmonary tuberculosis in a 51-year-old Japanese woman, who received treatment with infliximab for active rheumatoid arthritis. She had cough and sputum after the second infusion of the drug, small nodular lesions of right lung field and left lower lobe on her chest CT and a small nodular lesion of right cerebellar lobe on her cranial MRI were identified. Mycobacterium tuberculosis was cultured from her sputum. Therefore, we diagnosed her illness as pulmonary tuberculosis with a cerebellar lesion. The patient was treated with anti-tuberculosis drugs and showed marked improvement in lesions of the lung and brain. We considered this case a tuberculosis reactivation after infliximab treatment because of the short interval between the administration of infliximab and the occurrence of tuberculosis, and the complication of extrapulmonary lesion that suggested brain tuberculoma.
authors.affiliation: Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center.
authors.forename: Mikio
authors.initials: M
authors.lastname: Ubukata
authors.forename: Noboru
authors.initials: N
authors.lastname: Takayanagi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yanagisawa
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Miyahara
authors.forename: Motoko
authors.initials: M
authors.lastname: Kubota
authors.forename: Kenichirou
authors.initials: K
authors.lastname: Hara
authors.forename: Hiroo
authors.initials: H
authors.lastname: Saitoh
authors.forename: Daidou
authors.initials: D
authors.lastname: Tokunaga
authors.forename: Kazuki
authors.initials: K
authors.lastname: Kurashima
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sugita
mesh_terms: D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D018501:Antirheumatic Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000069285:Infliximab; D008875:Middle Aged; D016862:Tuberculoma, Intracranial / Q000209:etiology*; D014397:Tuberculosis, Pulmonary / Q000209:etiology*
chemical_list: D000911:Antibodies, Monoclonal; D018501:Antirheumatic Agents; D000069285:Infliximab