title: Dog factor differences in Can f 1 allergen production.
abstract: BACKGROUND
  The clinical importance of dog allergy is well known, but it is unknown if all types of dogs represent the same risk for allergic patients. The purpose of this work was to evaluate among 288 healthy dogs if the levels of Can f 1 on fur vary between breeds (German Shepherd, Pyrenean Shepherd, Poodle, Cocker spaniel, Spaniel, Griffon, Labrador retriever and Yorkshire terrier), gender, hormonal status, hair length, and according to the presence of seborrhea.
  
  
  METHODS
  Each dog was shaved in a limited area and Can f 1 concentrations were measured in mug/g fur by ELISA. The results (geometric mean values and 95% confidence intervals) were analyzed using analysis of variance and with nonparametric tests.
  
  
  RESULTS
  A wide variability in Can f 1 levels was found between dog breeds, from Labradors [1.99 (0.03-129.91)] to Yorkshires [16.72 (3.67-76.16)] and Poodles [17.04 (2.79-103.94)] but only the Labrador levels were significantly different from each other breed. Males produced more Can f 1 than females, 11.75 (1.27-108.40) vs 8.89 (0.91-86.39). No difference was found according to hair length or hormonal status. The seborrheic status highly (P = 0.0019) influenced the presence of Can f 1 on hair: 16.66 (1.59-173.96) vs 9.40 (1.03-85.70).
  
  
  CONCLUSIONS
  Breeds (Labrador retriever), sex and seborrhea seem to influence the levels of Can f 1 on fur.
authors.affiliation: UPRES 3287, Hôpital Sainte Marguerite, Université de la Méditerranée, Marseille, France.
authors.forename: M
authors.initials: M
authors.lastname: Ramadour
authors.forename: M
authors.initials: M
authors.lastname: Guetat
authors.forename: J
authors.initials: J
authors.lastname: Guetat
authors.forename: M
authors.initials: M
authors.lastname: El Biaze
authors.forename: A
authors.initials: A
authors.lastname: Magnan
authors.forename: D
authors.initials: D
authors.lastname: Vervloet
mesh_terms: D000485:Allergens / Q000032:analysis / Q000096:biosynthesis*; D000818:Animals; D052179:Antigens, Plant; D002369:Castration; D012628:Dermatitis, Seborrheic / Q000662:veterinary; D004283:Dog Diseases / Q000276:immunology; D004285:Dogs / Q000276:immunology*; D005260:Female; D006197:Hair / Q000033:anatomy & histology / Q000276:immunology; D006728:Hormones / Q000097:blood; D006801:Humans; D008297:Male; D012737:Sex Factors; D013045:Species Specificity
chemical_list: D000485:Allergens; D052179:Antigens, Plant; D006728:Hormones; C091462:allergen Can f I