title: SHP1 expression in bone marrow biopsies of myelodysplastic syndrome patients: a new prognostic factor.
abstract: Myelodysplastic syndrome (MDS) progresses into acute leukaemia with a variable time course. We analysed 45 newly diagnosed patients and found that the expression of the Src homology 2 domain-containing tyrosine phosphatase 1 (SHP1) had a significant impact on disease severity, progression and overall prognosis. Global or lineage-specific loss of SHP1 was observed by immunohistochemistry in bone marrow biopsies of MDS patients who progressed rapidly (P = 0.0021) and had shorter survival (P < 0.001). Cox regression analysis demonstrated that SHP1 expression in megakaryocytes had prognostic relevance for time to progression (P = 0.009) and overall survival (P = 0.001).
authors.affiliation: Inflammatory and Infectious Disease Center, The Burnham Institute, La Jolla, CA 92037, USA.
authors.forename: Armando V
authors.initials: AV
authors.lastname: Mena-Duran
authors.forename: Summanuna H
authors.initials: SH
authors.lastname: Togo
authors.forename: Lyudmila
authors.initials: L
authors.lastname: Bazhenova
authors.forename: Jose
authors.initials: J
authors.lastname: Cervera
authors.forename: Kelly
authors.initials: K
authors.lastname: Bethel
authors.forename: Maria L
authors.initials: ML
authors.lastname: Senent
authors.forename: Jorge
authors.initials: J
authors.lastname: Nieva
authors.forename: Guillermo F
authors.initials: GF
authors.lastname: Sanz
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Sanz
authors.forename: Alan
authors.initials: A
authors.lastname: Saven
authors.forename: Tomas
authors.initials: T
authors.lastname: Mustelin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D001853:Bone Marrow / Q000201:enzymology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000201:enzymology*; D011379:Prognosis; D054645:Protein Phosphatase 1; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism*; D016019:Survival Analysis
chemical_list: D015415:Biomarkers; D047908:Intracellular Signaling Peptides and Proteins; D054645:Protein Phosphatase 1; C509249:PTPN6 protein, human; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D017027:Protein Tyrosine Phosphatases