title: Ultrahigh-resolution optical coherence tomography with a fiber laser source at 1 microm.
abstract: We report a compact, high-power, fiber-based source for ultrahigh-resolution optical coherence tomography (OCT) near 1 microm. The practical source is based on a short-pulse, ytterbium-doped fiber laser and on generation of a continuum spectrum in a photonic crystal fiber. The broadband emission has an average power of 140 mW and offers an axial resolution of 2.1 microm in air (<1.6 microm in biological tissue). The generation of a broad bandwidth is robust and efficient. We demonstrate ultrahigh-resolution, time-domain OCT imaging of in vitro and in vivo biological tissues.
authors.affiliation: Beckman Laser Institute and Department of Biomedical Engineering, University of California, Irvine, Irvine, California 92612, USA.
authors.forename: Hyungsik
authors.initials: H
authors.lastname: Lim
authors.forename: Yi
authors.initials: Y
authors.lastname: Jiang
authors.forename: Yimin
authors.initials: Y
authors.lastname: Wang
authors.forename: Yu-Chih
authors.initials: YC
authors.lastname: Huang
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Chen
authors.forename: Frank W
authors.initials: FW
authors.lastname: Wise
mesh_terms: D004867:Equipment Design; D019544:Equipment Failure Analysis; D005240:Feasibility Studies; D005336:Fiber Optic Technology / Q000295:instrumentation* / Q000379:methods; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D007834:Lasers; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods