Smoking, apolipoprotein E genotype, and early onset of coronary heart disease.
BACKGROUND
We examined the association between smoking, apolipoprotein E (ApoE) genotype, and early onset of coronary heart disease (CHD).


METHODS
Smoking behaviour and ApoE genotype of 904 patients with CHD aged 30-70 years were assessed with respect to age at onset of CHD.


RESULTS
The adjusted odds ratio for early onset of CHD (< or =55 years) was 1.86 (95% confidence interval, 1.31-2.62) for smokers compared to non-smokers. The ApoE genotype had no significant influence and there was no significant interaction between ApoE genotype and smoking.


CONCLUSIONS
We found smoking but not ApoE genotype to be an independent risk factor for early onset of CHD.
Loew
Michael
M
Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany. loew@dzfa.uni-heidelberg.de
Hoffmann
Michael M
MM
Hahmann
Harry
H
März
Winfried
W
Rothenbacher
Dietrich
D
Brenner
Hermann
H
D000328:Adult; D017668:Age of Onset; D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics*; D015331:Cohort Studies; D003327:Coronary Disease / Q000209:etiology* / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*
D001057:Apolipoproteins E