title: Use of autologous platelet-rich plasma (PRP) in periodontal defect treatment after extraction of impacted mandibular third molars.
abstract: OBJECTIVE
  The extraction of mesioangular impacted third molars may cause multiple periodontal defects at the distal root of the second molar. Platelet-rich plasma (PRP) is a material containing many autologous growth factors that may be used in repairing and preventing periodontal complications at the distal root of the second molar adjacent to the extracted third molar.
  
  
  METHODS
  We analyzed the effects of autologous PRP on periodontal tissues after extraction of the third molar in 18 young patients (age, 21-26 years). Inclusion criteria were the presence of a pocket distal to the mandibular second molar with a probing depth>or=7.5 mm and a probing attachment level>or=6 mm.
  
  
  RESULTS
  We observed, at 12 weeks after surgery, a notable reduction in the probing depth and an improvement in the probing attachment level in those cases treated with PRP compared with the controls, as well as formation of new bone tissue in the bone defect.
  
  
  CONCLUSIONS
  We showed that PRP is effective in inducing and accelerating bone regeneration for the treatment of periodontal defects at the distal root of the mandibular second molar after surgical extraction of a mesioangular, deeply impacted mandibular third molar.
authors.affiliation: Dipartimento di Scienze Odontostomatologiche e Maxillofacciali, Universita' di Napoli Federico II, Italy.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Sammartino
authors.forename: Mariano
authors.initials: M
authors.lastname: Tia
authors.forename: Gaetano
authors.initials: G
authors.lastname: Marenzi
authors.forename: Alessandro Espedito
authors.initials: AE
authors.lastname: di Lauro
authors.forename: Elio
authors.initials: E
authors.lastname: D'Agostino
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Claudio
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000188:drug therapy* / Q000209:etiology; D001792:Blood Platelets; D001861:Bone Regeneration / Q000187:drug effects*; D005260:Female; D006133:Growth Substances / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008334:Mandible / Q000601:surgery; D008964:Molar, Third / Q000601:surgery*; D010514:Periodontal Pocket / Q000150:complications / Q000209:etiology; D010956:Plasmapheresis; D014081:Tooth Extraction / Q000009:adverse effects*; D014095:Tooth, Impacted / Q000601:surgery
chemical_list: D006133:Growth Substances