Plasma concentrations of retinol, carotene, and vitamin E and mortality in subjects with asbestosis in a cohort exposed to crocidolite in Wittenoom, Western Australia.
OBJECTIVE
We sought to examine the relationships between plasma concentrations of retinol, carotene, and vitamin E and mortality associated with asbestosis in people previously exposed to crocidolite.


METHODS
Cox regression modeling was applied to examine these relationships at the first measurement of each vitamin, at the measurement at each visit, and with the rate of change of each vitamin during the follow-up.


RESULTS
There were 76 deaths of people with asbestosis during the follow-up period and 1885 subjects censored. Mortality in subjects with asbestosis was inversely related to plasma levels of retinol and Vitamin E concentrations and to their rate of increase during the follow-up. Carotene concentrations at first visit were associated with lower mortality but not during the follow up period.


CONCLUSIONS
Chronically low levels of these vitamins are associated with an increased risk of dying with asbestosis.
Alfonso
Helman S
HS
School of Population Health, University of Western Australia, Perth, Western Australia. h.alfonso@curtin.edu.au
Fritschi
Lin
L
de Klerk
Nicholas H
NH
Ambrosini
Gina
G
Beilby
John
J
Olsen
Nola
N
Musk
A William
AW
D000368:Aged; D017638:Asbestos, Crocidolite / Q000633:toxicity*; D001195:Asbestosis / Q000097:blood / Q000401:mortality*; D002338:Carotenoids / Q000097:blood*; D015331:Cohort Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D016016:Proportional Hazards Models; D014801:Vitamin A / Q000097:blood*; D014810:Vitamin E / Q000097:blood*; D014904:Western Australia / Q000453:epidemiology
D014801:Vitamin A; D017638:Asbestos, Crocidolite; D014810:Vitamin E; D002338:Carotenoids