Antimitochondrial antibodies in patients with epilepsy.
Immune mechanisms have been implicated in the pathogenesis of epilepsy. An increased prevalence of autoantibodies, as well as changes in serum immunoglobulin concentrations, has been reported in patients with epilepsy. The presence of unspecific antimitochondrial antibodies (AMAs) and their possible associations with other immunological markers were evaluated in a cohort of 1386 adult patients with epilepsy and population-based reference subjects. Unspecific AMAs were more frequent in epilepsy patients than in the reference group. Thirty-seven epilepsy patients (3.9%) and eleven control subjects (1.9%) had unspecific AMAs (RR 2.1, CI 1.05-4.1, P=0.03). These antibodies were associated with long duration of epilepsy and old age at the onset of epilepsy among patients with epilepsy. Their presence was independent of other immunological markers, comorbidity, and epilepsy medications.
Ranua
Jouni
J
Department of Neurology, Seinäjoki Central Hospital, Hanneksenrinne 7, Seinäjoki, FIN-60220, Finland. jouni.ranua@ppl.inet.fi
Luoma
Katja
K
Auvinen
Anssi
A
Haapala
Anna-Maija
AM
Mäki
Markku
M
Peltola
Jukka
J
Raitanen
Jani
J
Isojärvi
Jouko I
JI
D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000378:metabolism; D001323:Autoantibodies / Q000276:immunology*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004827:Epilepsy / Q000453:epidemiology / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000276:immunology*; D016017:Odds Ratio; D015995:Prevalence; D012189:Retrospective Studies
D000974:Antibodies, Antinuclear; D001323:Autoantibodies