title: MTI of white matter hyperintensities.
abstract: The severity of tissue changes associated with incidental white matter hyperintensities (WMH) in the elderly cannot be sufficiently determined by conventional MRI. We, therefore, performed a regional analysis of the magnetization transfer ratio (MTR) maps obtained on a 1.5 T scanner from 198 neurologically asymptomatic participants of the Austrian Stroke Prevention Study (mean age 70, age range 52-87 years) in regard to WMH and predefined areas of normal appearing brain tissue. Fluid attenuated inversion recovery MRI was used to grade lesion severity and for lesion volume measurements. The MTR of WMH was always significantly lower than that of normal appearing white matter (NAWM) with an overall relative reduction of approximately 10% and decreased significantly with increasing scores of WMH severity (P = 0.02) and WMH volume (r = -0.24, P = 0.0016). NAWM MTR was not different between subjects with very few and extensive WMH and the WMH volume was associated with NAWM MTR of the frontal lobes only. Concerning a possible impact on cerebral functioning the MTR of the frontal NAWM was significantly associated with fine motor dexterity (P = 0.04) but not with cognitive performance. A significant decline of the MTR with aging was seen in both NAWM and cortex but not in WMH. We conclude that MTR measurements can serve to quantify WMH associated tissue damage. It is predominantly focal, relatively mild, increases with lesion size and may have remote effects on the frontal white matter.
authors.affiliation: Department of Neurology, Medical University Graz, Auenbruggerplatz 22, A-8036 Graz, Austria. franz.fazekas@meduni-graz.at
authors.forename: Franz
authors.initials: F
authors.lastname: Fazekas
authors.forename: Stefan
authors.initials: S
authors.lastname: Ropele
authors.forename: Christian
authors.initials: C
authors.lastname: Enzinger
authors.forename: Faton
authors.initials: F
authors.lastname: Gorani
authors.forename: Alexandra
authors.initials: A
authors.lastname: Seewann
authors.forename: Katja
authors.initials: K
authors.lastname: Petrovic
authors.forename: Reinhold
authors.initials: R
authors.lastname: Schmidt
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D001921:Brain / Q000473:pathology*; D003071:Cognition; D005500:Follow-Up Studies; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D009483:Neuropsychological Tests; D011446:Prospective Studies; D012307:Risk Factors; D020521:Stroke / Q000517:prevention & control