Phylogenetic heterogeneity of new HTLV type 1 isolates from southern India in subgroup A.
Seven isolates of human T cell leukemia virus type 1 (HTLV-1) were taken in southern India and phylogenetically analyzed to gain new insights into the origin and dissemination of HTLV-1 in the subcontinent. The new Indian HTLV-1s were found to be members of subgroup A (Transcontinental subgroup) of the Cosmopolitan group. They formed three different clusters (South African/Caribbean, Middle Eastern, and East Asian clusters). These results demonstrate that Indian HTLV-1s are genetically heterogeneous and include the most divergent strain of subgroup A. On the basis of these results, we speculate that subgroup A HTLV- 1s may have been present for thousands of years in India.
Ohkura
Sadayuki
S
Laboratory of Primate Model, Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan.
Yamashita
Masahiro
M
Ishida
Takafumi
T
Babu
Palla-George
PG
Koyanagi
Yoshio
Y
Yamamoto
Naoki
N
Miura
Tomoyuki
T
Hayami
Masanori
M
D000328:Adult; D002648:Child; D004279:DNA, Viral / Q000737:chemistry; D005260:Female; D015490:HTLV-I Infections / Q000821:virology*; D015368:Human T-lymphotropic virus 1 / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010802:Phylogeny; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA; D020079:Terminal Repeat Sequences / Q000235:genetics
D004279:DNA, Viral