title: Coating of a surface with 2-methacryloyloxyethyl phosphorylcholine (MPC) co-polymer significantly reduces retention of human pathogenic microorganisms.
abstract: The present study compares the retention of four species that are often isolated in association with biomedical device-related infections - Staphylococcus aureus, Streptococcus mutans, Pseudomonas aeruginosa, and Candida albicans - to three different surfaces. All four bacterial species were found to bind significantly less well to MPC-coated surfaces than to non-coated surfaces. We attribute this effect to the "superhydrophilicity" of MPC-coated surfaces, whereas hydrophobic surfaces are well known to reduce bacterial retention and thus to inhibit a crucial step in the formation of bacterial biofilms that lead to biomedical device-related infections and complications.
authors.affiliation: Department of Microbiology, Institute of Health Biosciences, Tokushima University Graduate School, Tokushima 770-8504, Japan.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Hirota
authors.forename: Keiji
authors.initials: K
authors.lastname: Murakami
authors.forename: Ken
authors.initials: K
authors.lastname: Nemoto
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Miyake
mesh_terms: D001422:Bacterial Adhesion / Q000187:drug effects* / Q000502:physiology; D001697:Biomedical and Dental Materials; D020099:Coated Materials, Biocompatible / Q000494:pharmacology; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008422:Materials Testing / Q000379:methods*; D008689:Methacrylates / Q000494:pharmacology*; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013499:Surface Properties
chemical_list: D001697:Biomedical and Dental Materials; D020099:Coated Materials, Biocompatible; D008689:Methacrylates; D010767:Phosphorylcholine; C070638:2-methacryloyloxyethyl phosphorylcholine