[Study of period and area factors of manganese exposure on the postnatal development of brain in rats].
OBJECTIVE
To investigate the effects of period and area factors of manganese exposure on the postnatal development of brain in rats.


METHODS
A combination of GFAP cytoimmunochemistry and imaging analysis was used to determine the morphological changes of glial cells and the average proportional densities of GFAP-immunochemistry positive products of different brain areas in different Mn-exposured period.


RESULTS
(1) In both one month's and two month's groups, no differences were found in the GFAP-immunochemistry extensities and the average proportional densities of GFAP reaction positive products between the Mn-exposured group and the control group in the somatic motor and sensory cortexes, but in the expyramid nuclei or areas, that were increased significantly than the the control group. (2) In three month's Mn-exposured groups, the GFAP-immunochemistry extensities and the average proportional densities of GFAP reaction positive products in all related areas of three groups were previously increased than that of the control group.


CONCLUSIONS
In the interferential factors of manganese exposure on the postnatal brain development, both the Mn-exposure period and the areas were the important ones.
He
Xin-hong
XH
Basic College of Guangdong College of Pharmacy, Guangzhou 510224, China.
Zhang
De-xing
DX
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000254:growth & development* / Q000378:metabolism; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D007120:Immunochemistry; D020149:Manganese Poisoning / Q000378:metabolism; D009457:Neuroglia / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D005904:Glial Fibrillary Acidic Protein