[Clinical research on relationship between angiogensis and TCM syndrome type of cyclomastopathy].
OBJECTIVE
To study the relationship between angiogensis and TCM Syndrome type of cyclomastopathy (CMP) to investigate the objective standardization of TCM Syndrome diagnosis of the disease.


METHODS
One hundred and forty patients with CMP were divided into three groups according to TCM syndrome typing. The pathological type, grade and expressions of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and microvascular density (MVD) in mammary biopsy were observed.


RESULTS
The expressions of VEGF, bFGF and MVD was different in CMP patients of different TCM types and pathological grades (P < 0.05). The proportion of atypical proliferation, the count of MVD and the expression of VEGF and bFGF were higher in patients of phlegm and stasis type than those in Gan stagnation caused Qistagnation type and Chong and Ren meridians disorder type.


CONCLUSIONS
TCM Syndrome type of CMP patients is related with vascular activity and grade of angiogensis. The pathological characteristics of mammary tissue and expression of VEGF, bFGF and MVD can be regarded as the objective indexes of TCM typing and clinical efficacy evaluation for CMP.
Song
Ai-li
AL
Department of Mastopathic Surgery, Hospital Affiliated to Shandong University of Traditional Chinese Medicine, Jinan. songaili218@sohu.com
Sun
Yi-an
YA
Yang
Yi
Y
D000328:Adult; D001940:Breast / Q000098:blood supply / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000096:biosynthesis; D005348:Fibrocystic Breast Disease / Q000145:classification* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008516:Medicine, Chinese Traditional; D009389:Neovascularization, Pathologic; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis
D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2