[Application of Danshen injection on early stage of renal transplantation].
OBJECTIVE
To investigate the effect of Danshen injection (DSI) on early stage of renal transplantation.


METHODS
One hundred and twelve patients in early stage after renal transplantation were allocated in the treated group, they were treated by conventional treatment with DSI 60 ml given additionally once a day for 10 days. And 109 patients who received conventional treatment alone after renal transplantation at the corresponding period were allocated in the control group. Indexes in the two groups, including volume of urine, serum creatinine (SCr), endogenous creatinine clearance rate, incidence of delayed graft function and acute rejection reaction, blood viscosity (BV), platelet aggregation rate (PAR) as well as the blood flow resistance in graft measured by color Doppler ultrasonography.


RESULTS
The urinary volume and endogenous creatinine clearance rate in the treated group were significantly higher, but levels of SCr, incidence of renal function recovery retardation, BV, PAR and blood flow resistance in graft were significantly lower than those in the control group (P < 0.05). The difference of incidence of acute rejection reaction between the two groups was insignificant (P > 0.05).


CONCLUSIONS
DSI can improve blood microcirculation, decrease the incidence of renal function recovery retardation, these effects are helpful for recovery of renal function after renal transplantation.
Tian
Xiao-hui
XH
Center of Renal Transplantation, The First Hospital Affiliated to Xi'an Jiaotong University, Xi'an.
Xue
Wu-jun
WJ
Ding
Xiao-ming
XM
D000293:Adolescent; D000328:Adult; D000368:Aged; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011184:Postoperative Period; D027561:Salvia miltiorrhiza; D014184:Transplantation, Homologous
D004365:Drugs, Chinese Herbal