Nonhuman primate models of asthma.
Asthma is a complex human disease that does not have an accurate counterpart in any common model organism. Most of our understanding of the immune mechanisms underlying asthma comes from studies in man and mouse. However, there are fundamental differences between the spontaneous disease in man and the experimentally induced counterparts in mice. We advocate more extensive use of nonhuman primate asthma models to reconcile these differences between man and mouse.
Coffman
Robert L
RL
Dynavax Technologies, Berkeley, CA 94710, USA. rcoffman@dvax.com
Hessel
Edith M
EM
D000818:Animals; D000906:Antibodies / Q000276:immunology; D001249:Asthma / Q000276:immunology* / Q000503:physiopathology*; D004195:Disease Models, Animal; D000882:Haplorhini; D008168:Lung / Q000502:physiology; D051379:Mice; D013045:Species Specificity
D000906:Antibodies