Expression and regulation of CCR1 in peritoneal macrophages from women with and without endometriosis.
CCR1 is a CC chemokine receptor with high affinity for RANTES (regulated upon activation, normal T cells expressed and secreted). CCR1 protein and mRNA concentrations in native peritoneal cells were twofold greater, in cultured peritoneal cells threefold greater, in patients with endometriosis compared to patients without endometriosis, as determined by Western blotting fluorescence activated cell sorting analysis, reverse transcription-polymerase chain reaction, and in situ hybridization.
Wieser
Fritz
F
Center for Reproductive Sciences, Department of Obstetrics and Gynecology, University of California, San Francisco, California, USA.
Dogan
Songül
S
Klingel
Karin
K
Diedrich
Klaus
K
Taylor
Robert N
RN
Hornung
Daniela
D
D000704:Analysis of Variance; D002478:Cells, Cultured; D004715:Endometriosis / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005434:Flow Cytometry; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D017403:In Situ Hybridization; D017737:Macrophages, Peritoneal / Q000378:metabolism*; D054389:Receptors, CCR1; D019707:Receptors, Chemokine / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D018709:Statistics, Nonparametric
C515300:CCR1 protein, human; D054389:Receptors, CCR1; D019707:Receptors, Chemokine