Kikuchi-Fujimoto disease is a rare cause of lymphadenopathy and fever of unknown origin in children: report of two cases and review of the literature.
Kikuchi-Fujimoto disease, a benign and unusual self-limiting histiocytic necrotizing lymphadenitis of unknown origin, should be included in the differential diagnosis of lymphadenopathy and fever of unknown origin. This disease mostly affects young Asian women and has rarely been reported in children, thus remaining a poorly recognized entity that is frequently confused with malignant lymphoma. The authors describe two children with Kikuchi-Fujimoto disease, with particular attention to diagnostic approach and clinical and histologic features of the disease.
Scagni
Paola
P
Department of Pediatrics, Children's Hospital Regina Margherita, Piazza Polonia 94, 10126 Turin, Italy. scagni@hotmail.com
Peisino
Maria Grazia
MG
Bianchi
Maurizio
M
Morello
Maura
M
Sardi
Nicola
N
Linari
Alessandra
A
Mastrodicasa
Luana
L
Madon
Enrico
E
Pecco
Paola
P
D000293:Adolescent; D001706:Biopsy; D002648:Child; D005335:Fever of Unknown Origin / Q000209:etiology*; D020042:Histiocytic Necrotizing Lymphadenitis / Q000150:complications* / Q000473:pathology; D006801:Humans; D008206:Lymphatic Diseases / Q000209:etiology* / Q000473:pathology; D008297:Male