A new botulinum toxin type A free of complexing proteins for treatment of cervical dystonia.
A new botulinum toxin type A free of complexing proteins (NT 201) was compared with BOTOX in patients with cervical dystonia by means of a double-blind noninferiority trial. Four hundred sixty-three patients received IM injections of 70 to 300 U of NT 201 or BOTOX and were followed up over 16 weeks. The study clearly shows that NT 201 is at least as effective and safe as BOTOX.
Benecke
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R
Department of Neurology, University of Rostock, Gehlsheimer Strasse 20 D-18147, Rostock, Germany. reiner.benecke@med.uni-rostock.de
Jost
W H
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Kanovsky
P
P
Ruzicka
E
E
Comes
G
G
Grafe
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S
D000906:Antibodies / Q000187:drug effects / Q000276:immunology; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry; D004185:Disability Evaluation; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004351:Drug Resistance / Q000276:immunology; D006801:Humans; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009334:Neck Muscles / Q000187:drug effects / Q000503:physiopathology; D014103:Torticollis / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome
D000906:Antibodies; D019274:Botulinum Toxins, Type A; C545476:incobotulinumtoxinA