title: mPer1 and mPer2 mutant mice show regular spatial and contextual learning in standardized tests for hippocampus-dependent learning.
abstract: Learning and memory, like most physiological processes, seem to be under the control of circadian rhythm. The recently cloned mPer1 and mPer2 genes play an important role in the regulation of the circadian rhythm. In this study, we tested mPer1 and mPer2 mutant mice in two different learning and memory paradigms, a water-maze place navigation task and contextual fear conditioning. In both learning tests, the hippocampus is critically involved. None of these learning types were affected by the mutations, suggesting that mPer1 and mPer2 do not play a major role in the regulation of hippocampus-dependent learning and memory.
authors.affiliation: Central Institute of Mental Health Mannheim (ZI), University of Heidelberg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Zueger
authors.forename: A
authors.initials: A
authors.lastname: Urani
authors.forename: S
authors.initials: S
authors.lastname: Chourbaji
authors.forename: C
authors.initials: C
authors.lastname: Zacher
authors.forename: H P
authors.initials: HP
authors.lastname: Lipp
authors.forename: U
authors.initials: U
authors.lastname: Albrecht
authors.forename: R
authors.initials: R
authors.lastname: Spanagel
authors.forename: D P
authors.initials: DP
authors.lastname: Wolfer
authors.forename: P
authors.initials: P
authors.lastname: Gass
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D018797:Cell Cycle Proteins; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D007858:Learning / Q000502:physiology*; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008568:Memory / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009483:Neuropsychological Tests; D009687:Nuclear Proteins / Q000235:genetics*; D056950:Period Circadian Proteins; D013028:Space Perception / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D018797:Cell Cycle Proteins; D009687:Nuclear Proteins; C539023:Per1 protein, mouse; C513312:Per2 protein, mouse; D056950:Period Circadian Proteins; D014157:Transcription Factors