[Recent TDI derivation of dioxin based on the reproductive and developmental toxicity].
In 1998, WHO-IPCS re-assessed the TDI of dioxin, which was derived from the body burdens of TCDD exposed to the experimental animals. Then, the international assessment agencies and governmental assessment agencies have conducted the dioxin fs health assessment using the similar method to the WHO-IPCS approach. The key endpoints were reproductive and developmental toxicity caused by in utero and lactational exposure. Each assessment agencies used the similar data set of the toxicity studies, however, there are some differences about the TDI derivation method and the selection of adverse endpoints. This report reviewed the recent reproductive and developmental toxicity studies of the dioxins and summarized the health assessment in the international or governmental agencies, and discussed the appropriate TDI derivation.
Hirose
Akihiko
A
Division of Risk Assessment.
Ema
Makoto
M
D000818:Animals; D001822:Body Burden; D004147:Dioxins / Q000633:toxicity*; D005260:Female; D005333:Fetus / Q000187:drug effects*; D048788:Growth and Development / Q000187:drug effects*; D006801:Humans; D007774:Lactation; D008297:Male; D008431:Maternal-Fetal Exchange; D008452:Maximum Allowable Concentration; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012098:Reproduction / Q000187:drug effects*
D004147:Dioxins