Quantification of L-type fatty acid binding protein in the urine of preterm neonates.
We measured urinary excretion of L-type fatty acid binding protein (L-FABP) in preterm neonates on days 1, 5-10, and 25-30 of life. Urinary L-FABP levels (expressed as the ratio to creatinine) in preterm neonates were considerably higher than those of healthy adults. They did not change significantly during the study period. Urinary L-FABP levels showed significant positive correlation with those of urinary N-acetyl-beta-D-glucosaminidase activity on day 1, and with those of 8-hydroxy-2'-deoxyguanosine on days 25-30. These results suggest that L-FABP is expressed in the neonatal kidney. Our results may also point to potential effects of proximal tubular damage and oxidative stress on urinary excretion of L-FABP.
Tsukahara
Hirokazu
H
Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Yoshida-gun, Fukui 910-1193, Japan. htsuka@fmsrsa.fukui-med.ac.jp
Sugaya
Takeshi
T
Hayakawa
Kazuyo
K
Mori
Yukiko
Y
Hiraoka
Masahiro
M
Hata
Atsuko
A
Mayumi
Mitsufumi
M
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000118:Acetylglucosaminidase / Q000652:urine; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000652:urine*; D007668:Kidney / Q000378:metabolism
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000118:Acetylglucosaminidase; D003849:Deoxyguanosine