title: [A spontaneous haemarthros in a postpartal woman: a case of acquired haemophilia A].
abstract: A woman aged 35 years presented with a haemarthros of the left elbow 6 months after her first parturition due to acquired haemophilia A. The bleeding episodes were mild and treated with recombinant activated factor VII. Because of the mild bleeding tendency and the chance of spontaneous remission it was decided to withhold immunosuppressive treatment. During the course of one year, the factor VIII level and the activated partial thromboplastin time (APTT) normalized and the autoantibodies disappeared. Four years after her first parturition, she had an uncomplicated pregnancy and the postpartum period was uneventful. Up to fourteen months postpartum, there are no signs of recurrence of the acquired haemophilia A. Acquired haemophilia A post partum usually presents in the first 3 months post partum. Frequently presenting symptoms are haemorrhages post partum, menorrhagia, soft-tissue haemorrhages and haemorrhages during surgical procedures. As a rule, the haemorrhages are slight. The titers of blocking antibodies are low in comparison with the titers in congenital haemophilia A.
authors.affiliation: Máxima Medisch Centrum, locatie Eindhoven, afd. Inwendige Geneeskunde, Eindhoven.
authors.forename: J J
authors.initials: JJ
authors.lastname: Koeijers
authors.forename: L Th
authors.initials: LT
authors.lastname: Vlasveld
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000096:biosynthesis / Q000276:immunology; D015944:Factor VIIIa / Q000276:immunology / Q000627:therapeutic use*; D005260:Female; D006467:Hemophilia A / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011644:Puerperal Disorders / Q000188:drug therapy / Q000209:etiology*
chemical_list: D001323:Autoantibodies; D015944:Factor VIIIa