UV-induced skin cancer: similarities--variations.
Skin cancer, the most common cancer world wide, encompasses different tumor entities, the keratinocyte-derived basal cell carcinoma (BCC), and squamous cell carcinoma (SCC) as well as the neuroectodermal malignant melanoma (MM) and the neuroendocrine Merkel cell carcinomas (MCC). While knowledge is significantly increasing about genetic changes contributing to BCCs and MMs, our understanding for the development and progression of SCCs and MCCs is still fragmentary. This review, thus, aims, on the one hand to summarize the present knowledge without claiming completeness and, on the other hand, to provide information on the HaCaT in vitro skin carcinogenesis model that is used to evaluate the functional consequence of genetic aberrations believed to play a role in skin cancer development and progression.
Boukamp
Petra
P
Division of Genetics of Skin Carcinogenesis, German Cancer Research Center Heidelberg, Germany. P.Boukamp@DKFZ-Heidelberg.de
D002280:Basal Cell Carcinoma / Q000235:genetics; D015266:Carcinoma, Merkel Cell / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics; D045744:Cell Line, Tumor; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002869:Chromosome Aberrations / Q000528:radiation effects; D018450:Disease Progression; D006801:Humans; D008545:Melanoma / Q000235:genetics; D009381:Neoplasms, Radiation-Induced / Q000235:genetics*; D012867:Skin / Q000528:radiation effects; D012878:Skin Neoplasms / Q000235:genetics*; D014466:Ultraviolet Rays / Q000009:adverse effects*