Protective effect of the HLA-Bw4I80 epitope and the killer cell immunoglobulin-like receptor 3DS1 gene against the development of hepatocellular carcinoma in patients with hepatitis C virus infection.
The aim of the present study was to investigate, in 152 Spanish patients infected with hepatitis C virus (HCV), the possibility that killer cell immunoglobulin-like receptors (KIRs) influence progression to hepatocellular carcinoma. KIRs are related to the activation and inhibition of natural killer cells and may play an important role in the innate response against infection with such viruses as HCV. We found that the human leukocyte antigen-Bw4I80 epitope and the KIR3DS1 gene were more frequent in HCV carriers than in patients with hepatocellular carcinoma. Moreover, these associations were not independent of each other--the KIR3DS1/Bw4I80 genotype clearly was also more frequent in HCV carriers (odds ratio, 24.22).
López-Vázquez
Antonio
A
Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain.
Rodrigo
Luis
L
Martínez-Borra
Jesus
J
Pérez
Ramón
R
Rodríguez
Manuel
M
Fdez-Morera
Juan L
JL
Fuentes
Dolores
D
Rodríguez-Rodero
Sandra
S
Gonzáez
Segundo
S
López-Larrea
Carlos
C
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000276:immunology*; D018450:Disease Progression; D000939:Epitopes / Q000235:genetics; D005260:Female; D005838:Genotype; D015235:HLA-B Antigens / Q000235:genetics*; D006526:Hepatitis C / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008103:Liver Cirrhosis / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011971:Receptors, Immunologic / Q000235:genetics*; D054340:Receptors, KIR; D054349:Receptors, KIR3DS1
D000939:Epitopes; D015235:HLA-B Antigens; C042388:HLA-Bw4 antigen; D011971:Receptors, Immunologic; D054340:Receptors, KIR; D054349:Receptors, KIR3DS1