GABA receptor 1 polymorphism (G1465A) and temporal lobe epilepsy.
OBJECTIVE
To reevaluate the genetic contribution of the polymorphism G1465A of the gene coding for gamma-aminobutyric acid (GABA)(B) receptor 1 subunit [GABA(B)(1)] in a sample of French patients with temporal lobe epilepsy (TLE) and to perform an exploratory analysis in other phenotypic subgroups.


METHODS
The 134 patients were genotyped for the polymorphism G1465A. This sample was divided in two groups. The first one had patients with nonlesional TLE, and the second one, with lesional TLE. Then these two groups were compared with a sample of 145 healthy individuals.


RESULTS
The genotype and allele distributions for the polymorphism G1465A showed no difference between patients and controls.


CONCLUSIONS
The association between the variant G1465A and the sample of patients could not be replicated, so these results exclude a major effect of this polymorphism in the susceptibility to nonlesional TLE. Larger samples should be tested to determine whether the G1465A in exon 7 of the GABA(B)(1) receptor gene is a susceptibility factor for nonlesional TLE.
Salzmann
Annick
A
Division of Neuropsychiatry, University Hospital of Geneva, Geneva, Switzerland.
Moulard
Bruno
B
Crespel
Arielle
A
Baldy-Moulinier
Michel
M
Buresi
Catherine
C
Malafosse
Alain
A
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D004833:Epilepsy, Temporal Lobe / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic; D018080:Receptors, GABA-B / Q000235:genetics; D015203:Reproducibility of Results
D005819:Genetic Markers; D018080:Receptors, GABA-B