Optimization of gas chromatographic method for the enantioseparation of arylpropionic non-steroidal anti-inflammatory drug methyl esters.
The gas chromatography (GC) method for enantioseparation of well-known non-steroidal anti-inflammatory drugs ibuprofen, fenoprofen and ketoprofen methyl esters mixture was developed. Best enantioseparation was performed on capillary column with heptakis-(2,3-di-O-methyl-6-O-t-butyldimethyl-silyl)-beta-cyclodextrin stationary phase and hydrogen used as a carrier gas. Initial temperature, program rate and carrier pressure were optimized to obtain best resolution between enantiomers.
Petrović
Marinko
M
PLIVA-Research and Development Ltd., Prilaz baruna Filipovića 29, 10 000 Zagreb, Croatia. mpetrovi@pliva.hr
Debeljak
Zeljko
Z
Blazević
Nikola
N
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000494:pharmacology*; D002384:Catalysis; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002845:Chromatography; D002849:Chromatography, Gas / Q000379:methods*; D003505:Cyclodextrins / Q000032:analysis; D004345:Drug Industry / Q000379:methods*; D004952:Esters / Q000737:chemistry; D005279:Fenoprofen / Q000032:analysis / Q000494:pharmacology; D007052:Ibuprofen / Q000032:analysis / Q000494:pharmacology; D007660:Ketoprofen / Q000032:analysis / Q000494:pharmacology; D011312:Pressure; D013237:Stereoisomerism; D013696:Temperature; D047392:beta-Cyclodextrins / Q000737:chemistry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003505:Cyclodextrins; D004952:Esters; D047392:beta-Cyclodextrins; D007660:Ketoprofen; C031215:betadex; D005279:Fenoprofen; D007052:Ibuprofen