title: A functional MRI comparison of patients with obsessive-compulsive disorder and normal controls during a Chinese character Stroop task.
abstract: Recent functional neuroimaging and neuropsychological studies have suggested that abnormal activity in the anterior cingulate cortex (ACC) might cause an action-monitoring dysfunction in obsessive-compulsive disorder (OCD). To identify the relationship between brain dysfunction and cognitive dysfunction, we examined regional brain changes in OCD with functional magnetic resonance imaging (fMRI) during the performance of a cognitive task. Participants comprised 24 patients with OCD and 14 normal controls. First, we compared the cognitive function in the two groups as assessed by several neuropsychological tests. Then we used fMRI to explore brain correlates of their performance during the Chinese character version of the Stroop test, a task that is strongly related to action-monitoring function. The two groups did not differ on the neuropsychological tests. Both groups also showed similar activation pattern on fMRI. The patients, however, showed weaker activation than the normal controls in the ACC and the right caudate nucleus.
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nakao
authors.forename: Akiko
authors.initials: A
authors.lastname: Nakagawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshiura
authors.forename: Eriko
authors.initials: E
authors.lastname: Nakatani
authors.forename: Maiko
authors.initials: M
authors.lastname: Nabeyama
authors.forename: Chika
authors.initials: C
authors.lastname: Yoshizato
authors.forename: Akiko
authors.initials: A
authors.lastname: Kudoh
authors.forename: Kyoko
authors.initials: K
authors.lastname: Tada
authors.forename: Kazuko
authors.initials: K
authors.lastname: Yoshioka
authors.forename: Midori
authors.initials: M
authors.lastname: Kawamoto
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology*; D002421:Caudate Nucleus / Q000378:metabolism / Q000503:physiopathology; D002531:Cerebellum / Q000378:metabolism / Q000503:physiopathology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D006179:Gyrus Cinguli / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000453:epidemiology* / Q000503:physiopathology*; D010296:Parietal Lobe / Q000378:metabolism / Q000503:physiopathology; D017397:Prefrontal Cortex / Q000378:metabolism / Q000503:physiopathology; D012720:Severity of Illness Index; D013788:Thalamus / Q000378:metabolism / Q000503:physiopathology