Increased cerebral serotonin-2A receptor binding in depressed patients with myocardial infarction.
Serotonin (5-HT) has been implicated in the pathophysiology of depression. It is not known whether depression in post-myocardial infarction (MI) patients is also serotonin-mediated. In somatically healthy depressed persons, increased brain 5-HT(2A) receptor binding has been reported in some studies. In animal studies, decreased serotonin activity was found after induction of MI. In the present study, it was hypothesized that depressed post-MI patients would exhibit increased brain 5-HT(2A) receptor binding compared with non-depressed post-MI patients. Single photon emission computed tomography (SPECT) with the radioligand 123I-5-I-R91150, a 5-HT(2A) receptor antagonist, was used to study 5-HT(2A) receptor binding. SPECT scans were performed in nine depressed post-MI patients, 10 non-depressed post-MI patients and 10 healthy control subjects. Results were analysed using statistical parametric mapping. Depressed post-MI patients showed increased 5-HT(2A) receptor binding compared with non-depressed post-MI patients, and MI patients showed decreased 5-HT(2A) receptor binding compared with control persons. Both post-MI depression and MI seem to be associated with changes in 5-HT(2A) receptor binding.
Schins
Annique
A
Department of Psychiatry, University Hospital Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.
Van Kroonenburgh
Marinus
M
Van Laere
Koen
K
D'haenen
Hugo
H
Lousberg
Richel
R
Crijns
Harry
H
Eersels
Jos
J
Honig
Adriaan
A
D001667:Binding, Competitive / Q000502:physiology*; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology*; D003866:Depressive Disorder / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000523:psychology*; D044402:Receptor, Serotonin, 5-HT2A / Q000378:metabolism*; D015899:Tomography, Emission-Computed, Single-Photon
D044402:Receptor, Serotonin, 5-HT2A