New amides of 5-acylamino-3-methyl-4-isothiazolecarboxylic acid and their immunotropic activity.
Several new amides 4 of 5-substituted 3-methyl-4-isothiazolecarboxylic acid were obtained. These compounds have acetylamino or benzoylamino groups in position 5 of the isothiazole ring. In position 4, the carboxylic group was transformed in the amides using amino-acid esters. Activities of the obtained derivatives were checked in the humoral immune response and delayed type hypersensitivity reaction to sheep red blood cells (SRBCs) in vivo.
Lipnicka
Urszula
U
Wrocław Medical University, Faculty of Pharmacy, Department of Organic Chemistry, Wrocław, Poland. urszula.lipnicka@mars.bf.uni.wroc.pl
Regiec
Andrzej
A
Sułkowski
Emil
E
Zimecki
Michał
M
D000577:Amides / Q000138:chemical synthesis* / Q000276:immunology / Q000494:pharmacology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects / Q000276:immunology; D049109:Cell Proliferation / Q000187:drug effects; D002626:Chemistry, Pharmaceutical / Q000379:methods / Q000639:trends; D004912:Erythrocytes / Q000187:drug effects / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000188:drug therapy / Q000276:immunology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D012756:Sheep; D013154:Spleen / Q000166:cytology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000276:immunology / Q000494:pharmacology
D000577:Amides; D013844:Thiazoles