title: [Interaction of hypoxia and haemostasis--hypoxia as a prothrombotic factor at high altitude?].
abstract: For an extended period of time various research projects have been conducted on the relationship of hypoxia and haemostasis. The enclosed article contains the conclusion to which extent lack of oxygen can activate the coagulation system and induce a prothrombotic state. The majority of studies proved a shortening of coagulation times during acute exposure to hypoxia, whereas activated parameters of coagulation and fibrinolysis like prothrombin fragment F1+2 as well as thrombin-antithrombin III complexes and D-dimer remained mostly unmodified. It is suggested that a prolonged sojourn at high altitudes could lead to activation of the coagulation system through an increase of haematocrit and blood viscosity. Recently it was proven that people living at high altitudes show an enhanced risk of stroke incidents. The significance of the change in haemostasis on that outcome has not yet been part of the research. However, it has been proven that the activity of the coagulation system does not play a pathophysiological part in the development of acute mountain sickness and high altitude pulmonary edema. Recent studies also demonstrated that moderate hypoxia during long haul flights may not be the main trigger in inducing deep vein thrombosis in passengers.
authors.affiliation: Institut für Urlaubs-, Reise- und Höhenmedizin, Private Universität für Gesundheitswissenschaften, Medizinische Informatik und Technik, Tirol, Hall i. Tirol, Osterreich. Wolfgang.schobersberger@umit.at
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Schobersberger
authors.forename: Georg
authors.initials: G
authors.lastname: Hoffmann
authors.forename: Hanns-Christian
authors.initials: HC
authors.lastname: Gunga
mesh_terms: D000401:Aircraft; D000532:Altitude Sickness / Q000503:physiopathology*; D001777:Blood Coagulation / Q000502:physiology; D001809:Blood Viscosity / Q000502:physiology; D005342:Fibrinolysis / Q000502:physiology; D006400:Hematocrit; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D020766:Intracranial Embolism / Q000503:physiopathology; D012307:Risk Factors; D013927:Thrombosis / Q000503:physiopathology*; D014195:Travel