Integrating Escherichia coli antimicrobial susceptibility data from multiple surveillance programs.
Collaboration between networks presents opportunities to increase analytical power and cross-validate findings. Multivariate analyses of 2 large, international datasets (MYSTIC and SENTRY) from the Global Advisory on Antibiotic Resistance Data program explored temporal, geographic, and demographic trends in Escherichia coli resistance from 1997 to 2001. Elevated rates of nonsusceptibility were seen in Latin America, southern Europe, and the western Pacific, and lower rates were seen in North America. For most antimicrobial drugs considered, nonsusceptibility was higher in isolates from men, older patients, and intensive care unit patients. Nonsusceptibility to ciprofloxacin was higher in younger patients, rose with time, and was not associated with intensive care unit status. In univariate analyses, estimates of nonsusceptibility from MYSTIC were consistently higher than those from SENTRY, but these differences disappeared in multivariate analyses, which supports the epidemiologic relevance of findings from the 2 programs, despite differences in surveillance strategies.
Stelling
John M
JM
Alliance for the Prudent Use of Antibiotics, Boston, Massachusetts 02115, USA. jstelling@rics.bwh.harvard.edu
Travers
Karin
K
Jones
Ronald N
RN
Turner
Philip J
PJ
O'Brien
Thomas F
TF
Levy
Stuart B
SB
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003627:Data Interpretation, Statistical; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects*; D004927:Escherichia coli Infections / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D007391:International Cooperation; D008826:Microbial Sensitivity Tests; D015999:Multivariate Analysis; D011159:Population Surveillance / Q000379:methods*
D000900:Anti-Bacterial Agents