title: Mediastinal Castleman disease associated with pulmonary carcinoma, mimicking N2 stage lung cancer.
abstract: A 67-year-old man presented at our hospital with suspected right lung cancer with mediastinal and hilar lymphadenopathy. Although swollen lymph nodes had first been noted 8 years previously, only minimal enlargement had occurred over the intervening period. Video-assisted thoracoscopic biopsy of the pulmonary lesion and the mediastinal and hilar lymph nodes was performed. Final histopathological diagnosis was a poorly differentiated adenocarcinoma of the lung staged as T1NOMO and a coexistent localized hyaline-vascular type of Castleman disease. Right upper lobectomy was performed and postoperative histological findings suggested that this was likely to be curative. This is a rare case of coexistence of lung cancer and Castleman disease, illustrating the difficulties in distinguishing lymph node metastasis from other pulmonary diseases.
authors.affiliation: Department of Thoracic Surgery, Tokyo Metropolitan Komagome Hospital, Japan.
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Horio
authors.forename: Tsunekazu
authors.initials: T
authors.lastname: Hijima
authors.forename: Koji
authors.initials: K
authors.lastname: Sakaguchi
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Kuwabara
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology*; D000368:Aged; D005871:Castleman Disease / Q000453:epidemiology*; D015897:Comorbidity; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology*; D008207:Lymphatic Metastasis; D008297:Male; D008477:Mediastinal Diseases / Q000453:epidemiology*; D020775:Thoracic Surgery, Video-Assisted