1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: application in the synthesis of potent human melanocortin-4 receptor selective agonists.
The discovery of 1-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid analogs as potent human melanocortin-4 selective agonists is described.
Bakshi
Raman K
RK
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065-0900, USA. Raman_bakshi@merck.com
Hong
Qingmei
Q
Olson
J T
JT
Ye
Zhixiong
Z
Sebhat
Iyassue K
IK
Weinberg
David H
DH
MacNeil
Tanya
T
Kalyani
Rubana N
RN
Tang
Rui
R
Martin
William J
WJ
Strack
Alison
A
McGowan
Erin
E
Tamvakopoulos
Constantin
C
Miller
Randy R
RR
Stearns
Ralph A
RA
Tang
Wei
W
Maclntyre
D Euan
DE
van der Ploeg
Lex H T
LH
Patchett
Arthur A
AA
Nargund
Ravi P
RP
D002264:Carboxylic Acids / Q000494:pharmacology*; D006801:Humans; D008968:Molecular Conformation; D018716:Molecular Mimicry; D011485:Protein Binding / Q000187:drug effects; D044105:Receptor, Melanocortin, Type 4 / Q000819:agonists* / Q000378:metabolism; D013329:Structure-Activity Relationship; D044005:Tetrahydroisoquinolines / Q000737:chemistry*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D002264:Carboxylic Acids; C470072:MC4R protein, human; D044105:Receptor, Melanocortin, Type 4; D044005:Tetrahydroisoquinolines; D013764:Tetrahydronaphthalenes; C078986:1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid