RGD mounted on an L-proline scaffold.
The construction of an L-proline scaffold that enforces a defined beta-turn loop for RGD is reported. A key feature was the use of SASRIN (super acid sensitive resin) that allowed solid-phase synthesis of the tetrapeptide. A HATU-induced cyclization of the sequence was successful, followed by a single acid-promoted deprotection of the final product.
Enholm
Eric
E
Department of Chemistry, University of Florida, Gainesville, FL 32611, USA. enholm@chem.ufl.edu
Bharadwaj
Ashwin
A
D003500:Cyclization; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D011392:Proline / Q000737:chemistry*
D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid; D011392:Proline