title: Usefulness of serum adiponectin level as a diagnostic marker of metabolic syndrome in obese Japanese children.
abstract: This study aimed 1) to investigate the relationship between serum adiponectin levels and metabolic disorders and 2) to clarify the usefulness of serum adiponectin level as a diagnostic marker of metabolic syndrome in obese Japanese children. One hundred obese boys aged 8 to 13 years were examined. Serum adiponectin levels were measured by radioimmunoassay using a commercial kit. Abdominal fat thickness (maximum preperitoneal fat thickness: P(max); minimum subcutaneous fat thickness: S(min)) was measured by ultrasonography. The relationships between adiponectin and clinical characteristics were analyzed by simple regression. The relationships between anthropometric measurements and metabolic disorders were analyzed among three groups divided according to adiponectin percentile. The prevalence of metabolic syndrome was also analyzed, with metabolic syndrome defined as the presence of three or more complications of obesity. The criteria for metabolic syndrome by adiponectin were subjected to a receiver operating characteristic (ROC) analysis. Body weight, waist circumference, P(max), alanine aminotransferase and fasting serum insulin were all inversely correlated with adiponectin. There were significant differences in the prevalence of severe obesity, the accumulation of visceral adipose tissue, hyperinsulinemia, high serum low density lipoprotein-cholesterol, the number of complications of obesity and the prevalence of metabolic syndrome among the three groups. The area under the ROC curve for adiponectin was 0.672 +/- 0.055 and the cut-off value was 6.65 microg/ml. Hypoadiponectinemia was associated with visceral fat accumulation and metabolic syndrome in obese Japanese boys. Evaluation of adiponectin might contribute to an early intervention for obese children with metabolic syndrome.
authors.affiliation: Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medicine and Dental Sciences, Niigata, Japan. yohei_oga@yahoo.co.jp
authors.forename: Yohei
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Toru
authors.initials: T
authors.lastname: Kikuchi
authors.forename: Keisuke
authors.initials: K
authors.lastname: Nagasaki
authors.forename: Makoto
authors.initials: M
authors.lastname: Hiura
authors.forename: Yukie
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Makoto
authors.initials: M
authors.lastname: Uchiyama
mesh_terms: D052242:Adiponectin; D000273:Adipose Tissue; D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002648:Child; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D006949:Hyperlipidemias / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D006973:Hypertension / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D007564:Japan; D008107:Liver Diseases / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D009765:Obesity / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D015995:Prevalence; D012372:ROC Curve; D012044:Regression Analysis
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D036341:Intercellular Signaling Peptides and Proteins