The genetics of muscle atrophy and growth: the impact and implications of polymorphisms in animals and humans.
Much of the vast diversity we see in animals and people is governed by genetic loci that have quantitative effects of phenotype (quantitative trait loci; QTLs). Here we review the current knowledge of the genetics of atrophy and hypertrophy in both animal husbandry (meat quantity and quality), and humans (muscle size and performance). The selective breeding of animals for meat has apparently led to a few genetic loci with strong effects, with different loci in different animals. In humans, muscle quantitative trait loci (QTLs) appear to be more complex, with few "major" loci identified to date, although this is likely to change in the near future. We describe how the same phenotypic traits we see as positive, greater lean muscle mass in cattle or a better exercise results in humans, can also have negative "side effects" given specific environmental challenges. We also discuss the strength and limitations of single nucleotide polymorphisms (SNP) association studies; what the reader should look for and expect in a published study. Lastly we discuss the ethical and societal implications of this genetic information. As more and more research into the genetic loci that dictate phenotypic traits become available, the ethical implications of testing for these loci become increasingly important. As a society, most accept testing for genetic diseases or susceptibility, but do we as easily accept testing to determine one's athletic potential to be an Olympic endurance runner, or quarterback on the high school football team.
Gordon
Erynn S
ES
Research Center for Genetic Medicine, Children's National Medical Center, 111 Michigan Ave NW, Washington, DC 20010, USA.
Gordish Dressman
Heather A
HA
Hoffman
Eric P
EP
D000822:Animal Husbandry; D000818:Animals; D002417:Cattle; D004992:Ethics, Medical; D005820:Genetic Testing; D014644:Genetic Variation; D006801:Humans; D006984:Hypertrophy / Q000235:genetics; D009132:Muscles / Q000473:pathology*; D009133:Muscular Atrophy / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics* / Q000502:physiology; D040641:Quantitative Trait Loci