[A pig model of myocardial infarction by intracoronary embolization with gelatin sponge].
OBJECTIVE
We produced a large-animal model of myocardial infarction induced by transcatheter embolization of the left coronary artery using a gelatin sponge.


METHODS
Seven pigs underwent transcatheter embolization of the left anterior descending artery (LAD) using gelatin sponge to produce anteroapical myocardial infarction (MI). 4 weeks later, Echocardiography, Coronary angiography and Pathology was performed, and the data were compared with those of the control group (n = 6).


RESULTS
The procedure mortality was 1 of 7. In the MI group, the LV end-diastolic dimension increased (control versus MI: 37.0 mm +/- 3.4 mm and 50.8 mm +/- 6.1 mm, P < 0.01), the ejection fraction (EF) decreased (control versus MI: 62.3% +/- 2.9% and 36.6% +/- 2.1%, P < 0.001). Coronary angiography revealed the LAD remained occluded. The postmortem specimen showed a transmural MI scar in the anteroseptal and apical regions in the MI group and the LV volumes at 30 mm Hg were 81.4 ml +/- 4.3 ml, the scar areas were 18.4% +/- 1.6% of total left ventricular free wall and the scar thickness was 3.5 mm +/- 0.8 mm. Histologic samples in the MI group stained with Masson's trichrome showed massive fibrosis in the border zone and patchy fibrosis in the remote region in the LV free wall, whereas the control group showed no fibrosis.


CONCLUSIONS
This pig model of myocardial infarction is reliable, reproducible, and similar to the human condition, amenable to investigate other investigation.
Li
Hou-huai
HH
Department of Cardiovascular Surgery, the First Affiliated Hospital, Soochow University, Suzhou 215006, China.
Shen
Zhen-ya
ZY
Hui
Jie
J
Li
Ke
K
Zheng
Lin
L
Jiao
Peng
P
Teng
Xiao-mei
XM
Zhu
Jian-zhong
JZ
Gao
Wei-dong
WD
Yang
Jun-hua
JH
Zhou
Bing-yuan
BY
D000818:Animals; D003331:Coronary Vessels; D004195:Disease Models, Animal; D005780:Gelatin; D009203:Myocardial Infarction / Q000209:etiology; D011161:Porifera; D013552:Swine
D005780:Gelatin