title: Synthesis and biological evaluation of novel angularly fused polycyclic coumarins.
abstract: In a three-step sequence, an array of angularly fused polycyclic heterocycles with coumarin, benzofuran and pyridine rings were synthesized from 4-bromomethylcoumarins and salicylonitrile. All the final compounds were fully characterized and screened for anti-microbial, anti-inflammatory and analgesic activities. Several compounds exhibited promising inflammation inhibiting and anti-microbial properties.
authors.affiliation: Department of Chemistry, Karnatak University, Dharwad-580003, India.
authors.forename: Imtyaz A
authors.initials: IA
authors.lastname: Khan
authors.forename: Manohar V
authors.initials: MV
authors.lastname: Kulkarni
authors.forename: M
authors.initials: M
authors.lastname: Gopal
authors.forename: M S
authors.initials: MS
authors.lastname: Shahabuddin
authors.forename: Chung-Ming
authors.initials: CM
authors.lastname: Sun
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001572:Benzofurans / Q000138:chemical synthesis / Q000494:pharmacology; D015169:Colony Count, Microbial; D003374:Coumarins / Q000138:chemical synthesis / Q000494:pharmacology*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis / Q000494:pharmacology; D010147:Pain Measurement / Q000187:drug effects*; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000700:Analgesics; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D001572:Benzofurans; D003374:Coumarins; D006576:Heterocyclic Compounds, 4 or More Rings; D011725:Pyridines; C030123:coumarin; C105430:benzofuran; C023666:pyridine