Synthesis and biological evaluation of novel angularly fused polycyclic coumarins.
In a three-step sequence, an array of angularly fused polycyclic heterocycles with coumarin, benzofuran and pyridine rings were synthesized from 4-bromomethylcoumarins and salicylonitrile. All the final compounds were fully characterized and screened for anti-microbial, anti-inflammatory and analgesic activities. Several compounds exhibited promising inflammation inhibiting and anti-microbial properties.
Khan
Imtyaz A
IA
Department of Chemistry, Karnatak University, Dharwad-580003, India.
Kulkarni
Manohar V
MV
Gopal
M
M
Shahabuddin
M S
MS
Sun
Chung-Ming
CM
D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001572:Benzofurans / Q000138:chemical synthesis / Q000494:pharmacology; D015169:Colony Count, Microbial; D003374:Coumarins / Q000138:chemical synthesis / Q000494:pharmacology*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis / Q000494:pharmacology; D010147:Pain Measurement / Q000187:drug effects*; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000700:Analgesics; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D001572:Benzofurans; D003374:Coumarins; D006576:Heterocyclic Compounds, 4 or More Rings; D011725:Pyridines; C030123:coumarin; C105430:benzofuran; C023666:pyridine