Synthesis of tertiary benzamides via Pd-catalyzed coupling of arylboronic esters and carbamoyl chlorides.
Ortho-substituted arylboronic esters are efficiently coupled with carbamoyl chlorides under Pd-catalysis to give tertiary benzamides.
Lysén
Morten
M
Department of Medicinal Chemistry, Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
Kelleher
Susan
S
Begtrup
Mikael
M
Kristensen
Jesper Langgaard
JL
D001549:Benzamides / Q000138:chemical synthesis*; D002219:Carbamates / Q000737:chemistry; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry; D004952:Esters / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
D001549:Benzamides; D002219:Carbamates; D002712:Chlorides; D004952:Esters; D010165:Palladium