title: Comparative pathogenicity of bacteraemic isolates of Aeromonas hydrophila and Klebsiella pneumoniae.
abstract: Two bacteraemic isolates of Aeromonas hydrophila and Klebsiella pneumoniae, Ah-2743 and Kp-129, respectively, were studied for their relative pathogenicity in comparison with Escherichia coli ATCC 25922. Ah-2743 caused significantly higher serum levels of tumour necrosis factor-alpha, interleukin (IL)-1beta or IL-6 in human whole blood, and higher serum IL-1beta and IL-6 levels in infected mice, than did Kp-129 and E. coli ATCC 25922. In addition, in BALB/c mice infected by intraperitoneal inoculation, Ah-2743 caused a higher fatality rate (80%) than did Kp-129 (0%). With intramuscular inoculation, Ah-2743 caused more rapid and intense local accumulation of inflammatory cells than did Kp-129, and myonecrosis was present only in Ah-2743-infected mice. These data indicate that Ah-2743 is more pathogenic than Kp-129 or E. coli ATCC 25922 for BALB/c mice. The cellular components or extracellular factors associated with increased cytokine induction and pathogenicity of A. hydrophila in mice merit further investigation.
authors.affiliation: Department of Medicine, National Cheng Kung University Medical College, Tainan, Taiwan.
authors.forename: W-C
authors.initials: WC
authors.lastname: Ko
authors.forename: S-R
authors.initials: SR
authors.lastname: Chiang
authors.forename: J-J
authors.initials: JJ
authors.lastname: Yan
authors.forename: Y-C
authors.initials: YC
authors.lastname: Chuang
mesh_terms: D000328:Adult; D016980:Aeromonas hydrophila / Q000302:isolation & purification / Q000472:pathogenicity*; D000818:Animals; D016470:Bacteremia / Q000382:microbiology*; D004195:Disease Models, Animal; D004926:Escherichia coli / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000382:microbiology / Q000473:pathology; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007710:Klebsiella Infections / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D007711:Klebsiella pneumoniae / Q000302:isolation & purification / Q000472:pathogenicity*; D051379:Mice; D008807:Mice, Inbred BALB C; D010538:Peritonitis / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D012867:Skin / Q000473:pathology; D018461:Soft Tissue Infections / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D016019:Survival Analysis; D013624:Taiwan; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D014774:Virulence
chemical_list: D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha