title: Convergent synthesis of a complex oxime library using chemical domain shuffling.
abstract: [reaction: see text] The synthesis of a complex hybrid oxime library is reported utilizing convergent ligation of alkoxyamine and carbonyl monomers via "chemical domain shuffling". Initial biological screening of the library against human small cell lung carcinoma (A549) cells led to the identification of a novel hybrid dimer in contrast to the corresponding monomeric compounds which were found to be inactive.
authors.affiliation: Department of Chemistry and Center for Chemical Methodology and Library Development, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.
authors.forename: Shun
authors.initials: S
authors.lastname: Su
authors.forename: Dayle E
authors.initials: DE
authors.lastname: Acquilano
authors.forename: Jeevanandam
authors.initials: J
authors.lastname: Arumugasamy
authors.forename: Aaron B
authors.initials: AB
authors.lastname: Beeler
authors.forename: Erin L
authors.initials: EL
authors.lastname: Eastwood
authors.forename: Joshua R
authors.initials: JR
authors.lastname: Giguere
authors.forename: Ping
authors.initials: P
authors.lastname: Lan
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Lei
authors.forename: Geanna K
authors.initials: GK
authors.lastname: Min
authors.forename: Adam R
authors.initials: AR
authors.lastname: Yeager
authors.forename: Ya
authors.initials: Y
authors.lastname: Zhou
authors.forename: James S
authors.initials: JS
authors.lastname: Panek
authors.forename: John K
authors.initials: JK
authors.lastname: Snyder
authors.forename: Scott E
authors.initials: SE
authors.lastname: Schaus
authors.forename: John A
authors.initials: JA
authors.lastname: Porco
mesh_terms: D020650:Combinatorial Chemistry Techniques; D007202:Indicators and Reagents; D015394:Molecular Structure; D010091:Oximes / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D007202:Indicators and Reagents; D010091:Oximes