title: Cerebellar abnormalities on proton MR spectroscopy in gluten ataxia.
abstract: Gluten sensitivity can manifest with ataxia. The metabolic status of the cerebellum was investigated in 15 patients with gluten ataxia and 10 controls using proton MR spectroscopy. Significant differences were present in mean N-acetyl aspartate levels at short echo time and N-acetyl aspartate/choline ratios at long echo time between the patient and control groups. These data support the hypothesis that cerebellar neuronal physiology differs between patients with gluten ataxia and healthy controls.
authors.affiliation: Academic Unit of Radiology, University of Sheffield, Sheffield, England. i.d.wilkinson@shef.ac.uk
authors.forename: I D
authors.initials: ID
authors.lastname: Wilkinson
authors.forename: M
authors.initials: M
authors.lastname: Hadjivassiliou
authors.forename: J M
authors.initials: JM
authors.lastname: Dickson
authors.forename: L
authors.initials: L
authors.lastname: Wallis
authors.forename: R A
authors.initials: RA
authors.lastname: Grünewald
authors.forename: S C
authors.initials: SC
authors.lastname: Coley
authors.forename: E
authors.initials: E
authors.lastname: Widjaja
authors.forename: P D
authors.initials: PD
authors.lastname: Griffiths
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000032:analysis; D002446:Celiac Disease / Q000175:diagnosis* / Q000503:physiopathology; D002524:Cerebellar Ataxia / Q000175:diagnosis* / Q000503:physiopathology; D002529:Cerebellar Nuclei / Q000473:pathology / Q000503:physiopathology; D002531:Cerebellum / Q000473:pathology / Q000503:physiopathology*; D002794:Choline / Q000032:analysis; D003401:Creatine / Q000032:analysis; D004292:Dominance, Cerebral / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D007294:Inositol / Q000032:analysis; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009457:Neuroglia / Q000473:pathology / Q000502:physiology; D009474:Neurons / Q000473:pathology / Q000502:physiology; D012016:Reference Values
chemical_list: D001224:Aspartic Acid; D007294:Inositol; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline