title: Fellowship of the rings: the replication of kinetoplast DNA.
abstract: Kinetoplastid protozoa such as trypanosomes and Leishmania are important because they cause human disease. These parasites are named after one of their most unusual features, a mitochondrial DNA known as kinetoplast DNA (kDNA). Unlike all other DNA in nature, kDNA comprises a giant network of interlocked DNA rings with a topology resembling that of medieval chain mail. The replication of the kDNA network is more complex than previously thought, and the discovery of new proteins involved in this process is currently the best approach for illuminating the replication mechanism.
authors.affiliation: Department of Biological Chemistry, Johns Hopkins Medical School, Baltimore, MD 21205, USA.
authors.forename: Beiyu
authors.initials: B
authors.lastname: Liu
authors.forename: Yanan
authors.initials: Y
authors.lastname: Liu
authors.forename: Shawn A
authors.initials: SA
authors.lastname: Motyka
authors.forename: Eddy E C
authors.initials: EE
authors.lastname: Agbo
authors.forename: Paul T
authors.initials: PT
authors.lastname: Englund
mesh_terms: D000818:Animals; D016831:Crithidia fasciculata / Q000235:genetics / Q000254:growth & development*; D004261:DNA Replication / Q000235:genetics / Q000502:physiology*; D018105:DNA, Kinetoplast / Q000096:biosynthesis* / Q000235:genetics; D008957:Models, Genetic; D015800:Protozoan Proteins / Q000235:genetics; D014345:Trypanosoma / Q000235:genetics* / Q000254:growth & development
chemical_list: D018105:DNA, Kinetoplast; D015800:Protozoan Proteins