title: Selenium deficiency: report of a case.
abstract: We report an 18-month-old Japanese boy with selenium deficiency. He had dry skin with irregularly shaped, erythematous changes on the cheeks, groin, hip, and extremities, erosions on the external urethral and anal orifices, and sparse, short, thin, light-coloured hair. He had received parenteral nutrition for 5 months because of juvenile polyposis. At presentation, his serum selenium level was less than 2.0 microg/dL (normal range, 10.6-17.4 microg/dL). His skin lesions responded well to supplementary treatment with sodium selenite. His skin symptoms were similar to those attributable to a deficiency of zinc which, like selenium, is an essential trace element. According to the literature, selenium deficiency is responsible for cardiomyopathy, which was diagnosed in our patient. The clinical similarity to zinc deficiency and the literature yielded important clues for a diagnosis of selenium deficiency in this patient.
authors.affiliation: Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Japan. takurok@m2.kufm.kagoshima-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Kanekura
authors.forename: S
authors.initials: S
authors.lastname: Yotsumoto
authors.forename: N
authors.initials: N
authors.lastname: Maeno
authors.forename: A
authors.initials: A
authors.lastname: Kamenosono
authors.forename: H
authors.initials: H
authors.lastname: Saruwatari
authors.forename: Y
authors.initials: Y
authors.lastname: Uchino
authors.forename: Y
authors.initials: Y
authors.lastname: Mera
authors.forename: T
authors.initials: T
authors.lastname: Kanzaki
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D007039:Hypotrichosis / Q000209:etiology; D007223:Infant; D008297:Male; D010288:Parenteral Nutrition / Q000009:adverse effects; D012643:Selenium / Q000172:deficiency*; D012871:Skin Diseases / Q000209:etiology* / Q000473:pathology; D018038:Sodium Selenite / Q000627:therapeutic use; D015032:Zinc / Q000172:deficiency
chemical_list: D012643:Selenium; D018038:Sodium Selenite; D015032:Zinc