title: Role of cell-cycle regulators in lung cancer.
abstract: Lung cancer is the leading cause of cancer death worldwide. Histologically, 80% of lung cancers are classified as non-small-cell lung cancer (NSCLC), and the remaining 20% as small-cell lung cancer (SCLC). Lung carcinoma is the result of molecular changes in the cell, resulting in the deregulation of pathways controlling normal cellular growth, differentiation, and apoptosis. This review summarizes some of the most recent findings about the role of cell-cycle proteins in lung cancer pathogenesis and progression.
authors.affiliation: Department of Cardio-Thoracic Sciences, II University of Naples, Naples, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Caputi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Russo
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Esposito
authors.forename: Alessandro
authors.initials: A
authors.lastname: Mancini
authors.forename: Antonio
authors.initials: A
authors.lastname: Giordano
mesh_terms: D018797:Cell Cycle Proteins / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology* / Q000503:physiopathology*
chemical_list: D018797:Cell Cycle Proteins