[Therapeutic effect of L-ornithine-L-aspartate on liver cirrhosis complicated by hepatic encephalopathy].
OBJECTIVE
To observe the therapeutic effects of L-ornithine-L-aspartate on liver cirrhosis complicated by hepatic encephalopathy.


METHODS
Eighty-five patient with liver cirrhosis complicated by hepatic encephalopathy were divided into therapy group (n=45) and control group (n=40). Patients in the control group were treated with routine comprehensive therapy, and those in the therapy group received additional intravenous administration with 40 ml L-ornithine-L-aspartate in 250 ml 10% glucose and saline (once daily, 7 days for a treatment course).


RESULTS
L-ornithine-L-aspartase significantly decreased blood ammonia and improved hepatic function (P<0.05 or 0.01). The therapeutic effects of therapy group was better than that of the control group (P<0.05), and no significant side effect was observed in L-ornithine-L-aspartate treatment.


CONCLUSIONS
L-ornithine-L-aspartate is effective for hepatic encephalopathy and has not obvious side effect.
Chen
Ming-fei
MF
Department of Infectious Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China. xiaotian151@yahoo.com.cn
Li
Ru-cheng
RC
Chen
Chang-hong
CH
Gao
Xiao-ci
XC
D004151:Dipeptides / Q000627:therapeutic use*; D005260:Female; D006501:Hepatic Encephalopathy / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007262:Infusions, Intravenous; D008103:Liver Cirrhosis / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
D004151:Dipeptides; C002939:ornithylaspartate