Mast cell changes in experimental diabetes: focus on attenuation of allergic events.
The prevalence of atopic diseases and diabetes is increasing worldwide though the concurrence of these pathologies in individual patients is found less frequent than it would be predicted. Moreover, co-existence of diabetes and allergy is generally marked by attenuation of their respective symptoms, and effective treatment of one disease exacerbates the other. This review gives an update of the state-of-the-art concerning the intercurrence of allergy and diabetes, particularly focusing on the consequences to the allergen-evoked vascular and cellular changes. It is proposed that the reduction in mast cell numbers and reactivity may be a pivotal mechanism behind the mutual exclusion phenomenon.
Carvalho
Vinicius F
VF
Laboratório de Inflamação, Departamento de Fisiologia e Farmacodinâmica, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ 21040-900, Brasil.
Barreto
Emiliano O
EO
Cordeiro
Renato S B
RS
Lagente
Vincent
V
Martins
Marco A
MA
e Silva
Patrícia M R
PM
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000276:immunology*; D005938:Glucocorticoids / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology / Q000276:immunology*; D007328:Insulin / Q000494:pharmacology; D007329:Insulin Antagonists / Q000494:pharmacology; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology*; D051381:Rats
D005938:Glucocorticoids; D007328:Insulin; D007329:Insulin Antagonists