title: Assessment of cyclin D1 overexpression as a prognostic factor in soft tissue sarcomas: role of laparoscopy and core needle biopsy.
abstract: BACKGROUND
  This study was designed to test cyclin D1 as a prognostic marker in patients with soft tissue sarcomas (STS), and to evaluate the usefulness of laparoscopy for determining cyclin D1 overexpression.
  
  
  METHODS
  The records of 62 patients with STS were collected: 28 with retroperitoneal STS (RSTS) and 34 with extremity STS (ESTS). A total of 51 patients underwent surgical resection, whereas 11 did not undergo surgery because of advanced tumor stage. Preoperative-intraoperative laparoscopic staging was performed for patients judged to be resectable at preoperative imaging.
  
  
  RESULTS
  Cyclin D1 was overexpressed in 30 (58.8%) of 51 resected patients and in 10 (90.9%) of 11 nonresected patients. Laparoscopy avoided unnecessary laparotomy in 9 (32.1%) of 28 RSTS patients.
  
  
  CONCLUSIONS
  High tumor grade, positive surgical margins, local recurrence, distant metastases, and cyclin D1 overexpression were related to poor survival. Multivariate analysis demonstrated cyclin D1 to be the only independent factor. Laparoscopy was shown to be useful for avoiding useless laparotomies.
authors.affiliation: Department of General and Emergency Surgery, Federico II University Medical School, 80131 Naples, Italy. dimusell@unina.it
authors.forename: M
authors.initials: M
authors.lastname: Musella
authors.forename: F
authors.initials: F
authors.lastname: Fazioli
authors.forename: S
authors.initials: S
authors.lastname: Lombardi
authors.forename: C I
authors.initials: CI
authors.lastname: Servodio
authors.forename: C
authors.initials: C
authors.lastname: De Martino
authors.forename: V
authors.initials: V
authors.lastname: Iacono
authors.forename: F
authors.initials: F
authors.lastname: Cigala
authors.forename: R
authors.initials: R
authors.lastname: Jovino
mesh_terms: D001707:Biopsy, Needle; D019938:Cyclin D1 / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012509:Sarcoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D012983:Soft Tissue Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D015996:Survival Rate
chemical_list: D019938:Cyclin D1