title: Investigation and management of an epidemic of Hydroview intraocular lens opacification.
abstract: BACKGROUND
  Opacification of Hydroview posterior chamber intraocular lenses had been prescribed, but many aspects of this complication remain unknown, including its aetiology, clinical features, pathogenesis, prognosis and treatment. This paper describes an epidemic of Hydroview intraocular lens (IOL) opacification.
  
  
  METHODS
  Subjects in whom the Hydroview IOL was implanted were recalled for evaluation of its transparency, assessment of contrast sensitivity (CS) [VCTS (Vistech CO, Dayton, Ohio, USA)] and visual acuity (LogMAR), and analysis of medical and surgical data. The results of IOL exchange in 69 eyes of 67 patients are also presented.
  
  
  RESULTS
  Of 103 patients recalled, 46 (44.6%) and 3 (2.9%) exhibited opacification of the implanted IOL in one and both eyes, respectively. CS was significantly worse in the presence of an opacified IOL (P<0.050), even when Snellen acuity was unaffected. Where the viscoelastic employed during the primary cataract surgery was reliably documented, VISCOAT was used in 100% of cases (43/43), whereas Healonid had not been used in any (0/57) (P<0.0001). Following IOL exchange, visual acuity improved from a mean (+/-SD) of 0.75 (0.41) to 0.4 (0.34) LogMAR.
  
  
  CONCLUSIONS
  The prevalence of Hydroview IOL opacification is associated with the use of VISCOAT in the primary cataract surgery, and there is a biochemically plausible rationale to account for this. Visual acuity and contrast sensitivity are adversely affected by opacification of the Hydroview IOL, but CS to a greater extent. Exchange of opaque IOLs is a visually rewarding procedure.
authors.affiliation: Department of Ophthalmology, Waterford Regional Hospital, Dunmore Road, Waterford, Ireland. raltaie2003@yahoo.com
authors.forename: R W
authors.initials: RW
authors.lastname: Altaie
authors.forename: T
authors.initials: T
authors.lastname: Costigan
authors.forename: S
authors.initials: S
authors.lastname: Donegan
authors.forename: P
authors.initials: P
authors.lastname: O'brien
authors.forename: U
authors.initials: U
authors.lastname: Mahmood
authors.forename: A J
authors.initials: AJ
authors.lastname: Bogdan
authors.forename: S
authors.initials: S
authors.lastname: Beatty
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015350:Contrast Sensitivity / Q000502:physiology; D016021:Epidemiologic Studies; D005260:Female; D006801:Humans; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011475:Prosthesis Failure; D012086:Reoperation; D012307:Risk Factors; D014792:Visual Acuity / Q000502:physiology