title: Gamma-knife radiosurgery for the treatment of ovarian cancer metastatic to the brain.
abstract: BACKGROUND
  Central nervous system (CNS) metastases from an ovarian malignancy are uncommon. The long-term prognosis for these patients is poor, with studies reporting a mean survival of less than 12 months.
  
  
  METHODS
  We present three ovarian cancer patients who developed metastatic disease to the brain. All patients were heavily pre-treated prior to the development of CNS disease. Following detection of CNS disease, they all were treated with multi-modality therapy including gamma-knife radiosurgery (GKRS). At this time, one patient is alive at 26 months following treatment with GKRS. The second and third patients survived for 88 and 22 months respectively, before succumbing to their disease.
  
  
  CONCLUSIONS
  Local control of ovarian cancer metastatic to the brain can be achieved in some patients with GKRS. Additional investigation into GKRS is warranted.
authors.affiliation: Gynecologic Oncology Associates, Hoag Cancer Center, 351 Hospital Road, Suite 507, Newport Beach, CA 92663, USA. jebbrown@cox.net
authors.forename: John V
authors.initials: JV
authors.lastname: Brown
authors.forename: Bram H
authors.initials: BH
authors.lastname: Goldstein
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Duma
authors.forename: Mark A
authors.initials: MA
authors.lastname: Rettenmaier
authors.forename: John P
authors.initials: JP
authors.lastname: Micha
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000556:secondary* / Q000601:surgery*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D016634:Radiosurgery