Differential action of domperidone to modify emesis and behaviour induced by apomorphine in the ferret.
The action of domperidone (1 mg/kg, i.p.) on spontaneous behaviour and the emesis and behavioural change induced by apomorphine (0.25 mg/kg, s.c.) were studied in the ferret. Domperidone was inactive to modify spontaneous behaviour but apomorphine-induced emesis and increased locomotor activity (distance travelled and velocity of movement; P<0.05); the emesis, but not the modification of locomotor activity was antagonized significantly (P<0.01) by domperidone. However, apomorphine did not modify significantly other behavioural measures (i.e. lip licking, rearing, burrowing, backward walking, curling-up activity, or defecatory frequency; P>0.05). The action of apomorphine to modify behaviour and its interaction with domperidone in this species is discussed in relation to animal models of nausea.
Lau
Angie H Y
AH
Emesis Research Group, Department of Pharmacology and Department of Anatomy, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, PR China.
Ngan
Man-P
MP
Rudd
John A
JA
Yew
David T W
DT
D000818:Animals; D000932:Antiemetics / Q000494:pharmacology*; D000978:Antiparkinson Agents / Q000494:pharmacology / Q000633:toxicity; D001058:Apomorphine / Q000494:pharmacology* / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects*; D004294:Domperidone / Q000494:pharmacology*; D005289:Ferrets; D006185:Habituation, Psychophysiologic; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control*
D000932:Antiemetics; D000978:Antiparkinson Agents; D004294:Domperidone; D001058:Apomorphine