[Determination of oxidation-reduction level in patients with rheumatoid arthritis].
OBJECTIVE
To examine the oxidation or reduction products in patients with rheumatism arthritis (RA), and investigate the relationship between oxidation or reduction products and occurrence and development of RA.


METHODS
The serum levels of total ascorbic acid (TAA), dehydroascorbic acid (DHAA)/TAA, vitamin E, advanced oxidation protein products (AOPP) and malondialdehyde (MDA) were detected by high-performance liquid chromatography with electrochemical detection in 83 RA patients and 30 healthy adults. Correlation analysis of AOPP, MDA and hs-CRP was performed.


RESULTS
Compared with normal control group, significantly higher serum MDA, DHAA/TAA, and AOPP levels were detected in RA patients (P<0.05), but vitamin E showed no significant difference (P<0.05). Linear regression analysis showed that MDA (P<0.01) was positively but AOPP (P>0.05) negatively correlated to hs-CRP.


CONCLUSIONS
Oxidation or reduction products in serum of RA patients increases significantly, which may be an important mechanism for the occurrence and development of RA. Serum AOPP and MDA levels can reflect the oxidation status in RA patients.
Cai
Wen-can
WC
Department of Clinical Laboratory, Yuebei People's Hospital, Shaoguan 512026, China.
Wang
Hai
H
Li
Rui-qing
RQ
Gao
Lin
L
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D001205:Ascorbic Acid / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D003683:Dehydroascorbic Acid / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D010084:Oxidation-Reduction; D014810:Vitamin E / Q000097:blood
D014810:Vitamin E; D008315:Malondialdehyde; D001205:Ascorbic Acid; D003683:Dehydroascorbic Acid