title: Synthesis and biological evaluation of novel 1,4-naphthoquinone derivatives as antibacterial and antiviral agents.
abstract: A series of 1,4-naphthoquinone derivatives were synthesized and evaluated for antibacterial and antiviral activities. The structure-activity relationships of these compounds were also studied. The results suggest that compounds 9-22 showed in vitro marked antibacterial activity. Compounds 4c and 7a showed inhibitory effect against RNA dependent RNA polymerase induced poliovirus type 2 infected HeLa cells.
authors.affiliation: Department of Chemistry, Lucknow University, Lucknow 226007, India. vishnutandon@yahoo.co.in
authors.forename: Vishnu K
authors.initials: VK
authors.lastname: Tandon
authors.forename: Dharmendra B
authors.initials: DB
authors.lastname: Yadav
authors.forename: Ravindra V
authors.initials: RV
authors.lastname: Singh
authors.forename: Meenu
authors.initials: M
authors.lastname: Vaish
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Chaturvedi
authors.forename: Praveen K
authors.initials: PK
authors.lastname: Shukla
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009285:Naphthoquinones / Q000138:chemical synthesis / Q000494:pharmacology; D017955:Poliovirus / Q000187:drug effects; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D009285:Naphthoquinones; D012324:RNA-Dependent RNA Polymerase; C035342:1,4-naphthoquinone