Model systems for flavoenzyme activity: site-isolated redox behavior in flavin-functionalized random polystyrene copolymers.
[reaction: see text] A model system has been developed to study the redox behaviors of flavin derivatives appended onto random polystyrene copolymers through "click" chemistry strategies. The results demonstrate that flavin units attached onto polymers exhibit site-isolated redox behaviors, yielding new materials with electrochemically tunable associations (K(a)(ox) = 450 M(-)(1), K(a)(red) = 18,200 M(-)(1)) to complementary diamidopyridine (DAP) functionality.
Carroll
Joseph B
JB
Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA.
Jordan
Brian J
BJ
Xu
Hao
H
Erdogan
Belma
B
Lee
Lisa
L
Cheng
Lily
L
Tiernan
Christopher
C
Cooke
Graeme
G
Rotello
Vincent M
VM
D004563:Electrochemistry / Q000379:methods*; D005415:Flavins / Q000737:chemistry* / Q000378:metabolism; D007700:Kinetics; D008958:Models, Molecular; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011137:Polystyrenes / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry / Q000378:metabolism; D013816:Thermodynamics
D005415:Flavins; D011137:Polystyrenes; D011725:Pyridines