Trial to evaluate the management of paroxysmal supraventricular tachycardia during an electrophysiology study with tecadenoson.
BACKGROUND
Tecadenoson is a potent selective A1-adenosine receptor agonist with a dose-dependent negative dromotropic effect on the AV node. Tecadenoson terminates induced paroxysmal supraventricular tachycardia (PSVT) without the clinically significant side effects caused by stimulation of other adenosine receptors. This trial was designed to determine a safe and effective tecadenoson bolus for termination of electrophysiologically induced PSVT.


RESULTS
Patients with a history of symptomatic PSVT and inducible PSVT at the time of a clinically indicated electrophysiology study were randomized into a multicenter, double-blind, placebo-controlled trial. Five 2-dose tecadenoson bolus regimens were evaluated versus placebo (75/150, 150/300, 300/600, 450/900, 900 microg/900 microg). The second bolus was administered only if PSVT persisted for 1 minute after the first bolus. Each tecadenoson regimen resulted in a significant therapeutic conversion rate compared with placebo (range, 50.0% to 90.3%, analysis of all patients dosed; n=181; P<0.0005). Conversion by the first bolus was dose related (range: placebo, 3.3% to 86.7% for 900 microg/900 microg). Time to conversion was dose dependent, with a median time of <1 minute for the 3 highest dose regimens. Postconversion arrhythmias were transient, requiring no additional treatment in 4 regimens (including placebo). Transient second- and third-degree heart block occurred at higher doses (300/600, 450/900, 900 microg/900 microg) and was supported with backup pacing when needed. No effect on blood pressure was observed. Ten patients with a history of asthma or chronic obstructive pulmonary disease tolerated tecadenoson without bronchospasm.


CONCLUSIONS
We identified an optimal tecadenoson regimen (300 microg/600 microg) that effectively and rapidly converted 90% (28 of 31) of PSVT patients to normal sinus rhythm with no significant adverse effects.
Ellenbogen
Kenneth A
KA
Medical College of Virginia, Richmond, VA 23298-0053, USA. kellenbogen@pol.net
O'Neill
Gearoid
G
Prystowsky
Eric N
EN
Camm
John A
JA
Meng
Lixin
L
Lieu
Hsiao Dee
HD
Jerling
Markus
M
Shreeniwas
Revati
R
Belardinelli
Luiz
L
Wolff
Andrew A
AA
D000241:Adenosine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D058907:Adenosine A1 Receptor Agonists; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D019468:Disease Management; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004594:Electrophysiology; D005260:Female; D005663:Furans / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006323:Heart Arrest / Q000139:chemically induced; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010490:Pericardial Effusion / Q000139:chemically induced; D013575:Syncope / Q000139:chemically induced; D013617:Tachycardia, Supraventricular / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000139:chemically induced
D058907:Adenosine A1 Receptor Agonists; D005663:Furans; C118601:tecadenoson; D000241:Adenosine