title: [Relation between the expression of sIL-2R and the relapse in patients with acute lymphoblastic leukemia].
abstract: OBJECTIVE
  To explore the relation of the serum level of sIL-2R in relapse patients with acute lymphoblastic leukemia (ALL).
  
  
  METHODS
  With ELISA, we determined the levels of sIL-2R of 48 patients with ALL after their first diagnoses, complete remission 1 and relapse. The levels of sIL-2R of 30 patients from complete remission 1 to relapse were monitored.
  
  
  RESULTS
  The levels of sIL-2R were higher in the relapse group and first diagnosed group than in the control. The levels of sIL-2R were higher in the relapse group and first diagnosed group than in the complete remission 1 group. However, the difference between the complete remission 1 and the control had no statistical significance. When we determined the levels of sIL-2R dynamically, we found that after complete remission, the levels of sIL-2R decreased, however, before one month of hematological relapse, the levels of sIL-2R increased.
  
  
  CONCLUSIONS
  Monitor of the level of sIL-2R can predict impending relapse of patients with ALL and is helpful to early diagnosis of relapse.
authors.affiliation: Department of Hematology, Peking University Shenzhen Hospital, Shenzhen 518036, China. liubs6666@tom.com
authors.forename: Jin
authors.initials: J
authors.lastname: Liu
authors.forename: Deng-shu
authors.initials: DS
authors.lastname: Wu
authors.forename: Shen
authors.initials: S
authors.lastname: Zhang
authors.forename: Chen-hua
authors.initials: CH
authors.lastname: Yan
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhou
authors.forename: Yong-ding
authors.initials: YD
authors.lastname: Zhang
authors.forename: Zhen-hua
authors.initials: ZH
authors.lastname: Qi
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism* / Q000473:pathology; D015375:Receptors, Interleukin-2 / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D015375:Receptors, Interleukin-2