title: Simultaneous bilateral breast carcinoma: Histopathological characteristics and CD44/catenin-cadherin profile.
abstract: Family history of breast carcinoma, multicentric tumor foci in one breast, and in situ lobular carcinoma increase the risk of bilateral breast cancer (BBC), synchronous or metachronous. Synchronous tumors are designated as simultaneous breast carcinoma if they appear at the same time. The CD44 family and cadherin/catenin immunophenotype of this group of BBCs has not yet been evaluated. The aim of this study was to compare clinicopathological characteristics and immunohistochemical profiles of simultaneous BBC and corresponding lymph node metastases in eight patients.
  
  
  
  In toto 15 primary and 9 metastatic tumors were evaluated. The expression of CD44 variant isoforms, beta-catenin, E, P and N-cadherin were evaluated by immunohistochemistry. Rare types of breast carcinoma were frequent in this group of patients. There were 6 pleomorphic lobular, 5 invasive ductal of usual type, 3 atypical medullary carcinomas, 2 mucinous and one invasive micropapillary carcinoma. The expression CD44v6 was most frequent, followed by CD44v3-10, CD44v5, and CD44v3. CD44v4 was generally not expressed. E-cadherin was expressed in 80% primary tumors, 40% expressed N-cadherin, and 66% expressed P-cadherin.
  
  
  
  Generally, simultaneous carcinomas had different morphology and different immunophenotype. Each primary tumor was more similar to its corresponding metastatic tumor than to the contralateral primary tumor.
authors.affiliation: Department of Pathology, Alexander University Hospital, Medical University, Sofia, Bulgaria. assia.bassarova@radiumhospitalet.no
authors.forename: A V
authors.initials: AV
authors.lastname: Bassarova
authors.forename: E
authors.initials: E
authors.lastname: Torlakovic
authors.forename: T
authors.initials: T
authors.lastname: Sedloev
authors.forename: S L
authors.initials: SL
authors.lastname: Hristova
authors.forename: D V
authors.initials: DV
authors.lastname: Trifonov
authors.forename: J M
authors.initials: JM
authors.lastname: Nesland
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D015820:Cadherins / Q000032:analysis; D003598:Cytoskeletal Proteins / Q000032:analysis; D005260:Female; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis; D007150:Immunohistochemistry; D008875:Middle Aged; D015534:Trans-Activators / Q000032:analysis; D051176:beta Catenin
chemical_list: D014408:Biomarkers, Tumor; C497483:CD44 protein, human; C121450:CD44V3,8-10; C113800:CD44v5 antigen; C112697:CD44v6 antigen; C495270:CTNNB1 protein, human; D015820:Cadherins; D003598:Cytoskeletal Proteins; D006023:Glycoproteins; D018960:Hyaluronan Receptors; D015534:Trans-Activators; D051176:beta Catenin