title: Blood lipid peroxides and muscle damage increased following intensive resistance training of female weightlifters.
abstract: The aim of this study was to examine changes in muscle cell injury and antioxidant capacity of weightlifters following a 1-week intensive resistance-training regimen. Thirty-six female subjects participated in this study, and their ages ranged from 18 to 25 years. The sample group included 19 elite weightlifters with more than 3 years of weightlifting training experience, while the control group comprised 17 non-athletic individuals. Compared with non-athletes, weightlifters had significantly lower glutathione peroxidase activity and plasma vitamin C concentrations. Weightlifters also had significantly higher malondialdehyde + 4-hydroxy 2-(E)-nonenal (MDA+4-HNE) and thiobarbituric acid-reactive substance (TBARS) levels and creatine kinase (CK) activity. For weightlifters, the plasma vitamin E level and the activity of superoxide dismutase (SOD) decreased, and CK activity increased significantly (P < 0.05) after a 1-week intensive resistance-training regimen. Both the TBARS levels and CK activity returned to values of pre-intensive training after a 2-day rest. The MDA+4-HNE level strongly correlated with CK activity in weightlifters (P < 0.05). In conclusion, both long-term exercise training and 1 week of intensive resistance training resulted in increased oxidative stress and cell injury in female weightlifters. Furthermore, proper rest after intensive training was found to be important for recovery.
authors.affiliation: Graduate Institute of Nutrition and Health Science, Taipei Medical University, Taiwan, ROC.
authors.forename: Jen-Fang
authors.initials: JF
authors.lastname: Liu
authors.forename: Wei-Yin
authors.initials: WY
authors.lastname: Chang
authors.forename: Kuei-Hui
authors.initials: KH
authors.lastname: Chan
authors.forename: Wen-Yee
authors.initials: WY
authors.lastname: Tsai
authors.forename: Chen-Li
authors.initials: CL
authors.lastname: Lin
authors.forename: Mei-Chieh
authors.initials: MC
authors.lastname: Hsu
mesh_terms: D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D003402:Creatine Kinase / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D018482:Muscle, Skeletal / Q000293:injuries* / Q000378:metabolism / Q000473:pathology; D014891:Weight Lifting / Q000502:physiology*
chemical_list: D000975:Antioxidants; D008054:Lipid Peroxides; D003402:Creatine Kinase