title: [2D imaging simulations of a small animal PET scanner with DOI measurement: jPET-RD.].
abstract: We present a preliminary study on the design of a high sensitivity small animal DOI-PET scanner: jPET-RD (for Rodents with DOI detectors), which will contribute to molecular imaging. The 4-layer DOI block detector for the jPET-RD that consists of scintillation crystals (1.4 mm x 1.4 mm x 4.5 mm) and a flat panel position-sensitive photomultiplier tube (52 mm x 52 mm) was previously proposed. In this paper, we investigate imaging performance of the jPET-RD through numerical simulations. The scanner has a hexagonal geometry with a small diameter and a large axial aperture. Therefore DOI information is expected to improve resolution uniformity in the whole field of view (FOV). We simulate the scanner for various parameters of the number of DOI channels and the crystal length. Simulated data are reconstructed using the maximum likelihood expectation maximization with accurate system modeling. The trade-off results between background noise and spatial resolution show that only shortening the length of crystal does not improve the trade-off at all, and that 4-layer DOI information improves uniformity of spatial resolution in the whole FOV. Excellent performance of the jPET-RD can be expected based on the numerical simulation results.
authors.affiliation: Department of Medical Physics, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba-shi, 263-8555, Japan. taiga@nirs.go.jp.
authors.forename: Taiga
authors.initials: T
authors.lastname: Yamaya
authors.forename: Keishi
authors.initials: K
authors.lastname: Kitamura
authors.forename: Naoki
authors.initials: N
authors.lastname: Hagiwara
authors.forename: Takashi
authors.initials: T
authors.lastname: Obi
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Eiji
authors.initials: E
authors.lastname: Yoshida
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Tsuda
authors.forename: Naoko
authors.initials: N
authors.lastname: Inadama
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Wada
authors.forename: Hideo
authors.initials: H
authors.lastname: Murayama
mesh_terms: D000818:Animals; D004867:Equipment Design; D049268:Positron-Emission Tomography