title: Seizure worsening caused by decreased serum valproate during meropenem therapy.
abstract: Serum concentrations of valproate were reduced and seizures were exacerbated by concomitant meropenem therapy in a child with a neurodegenerative disorder and epilepsy. In this patient, a rapid decline of valproate serum concentrations was observed on two occasions with meropenem antibiotic therapy. This event was the most likely cause of observed seizure exacerbation. Meropenem should be used with caution in patients treated with valproate owing to the drastic lowering of serum valproate concentration and the consequent risk of seizure worsening.
authors.affiliation: Department of Neurological Sciences, University of Bologna, Italy. margherita.santucci@unibo.it
authors.forename: Margherita
authors.initials: M
authors.lastname: Santucci
authors.forename: Antonia
authors.initials: A
authors.lastname: Parmeggiani
authors.forename: Roberta
authors.initials: R
authors.lastname: Riva
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000927:Anticonvulsants / Q000097:blood* / Q000494:pharmacology / Q000627:therapeutic use; D002648:Child; D004347:Drug Interactions; D004827:Epilepsy / Q000097:blood* / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000077731:Meropenem; D019150:Neuroaxonal Dystrophies / Q000150:complications; D013845:Thienamycins / Q000009:adverse effects*; D014635:Valproic Acid / Q000097:blood* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000927:Anticonvulsants; D013845:Thienamycins; D014635:Valproic Acid; D000077731:Meropenem