title: Epigenome programming by Polycomb and Trithorax proteins.
abstract: Polycomb group (PcG) and Trithorax group (TrxG) proteins work, respectively, to maintain repressed or active transcription states of developmentally regulated genes through cell division. Data accumulated in the recent years have increased our understanding of the mechanisms by which PcG and TrxG proteins regulate gene expression. The discovery that histone methylation can serve as a specific mark for PcG and TrxG complexes has provided new insight into the mechanistic function of this cell-memory system.
authors.affiliation: Dulbecco Telethon Institute, Naples, Italy.
authors.forename: Filippo M
authors.initials: FM
authors.lastname: Cernilogar
authors.forename: Valerio
authors.initials: V
authors.lastname: Orlando
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D002843:Chromatin / Q000737:chemistry; D004268:DNA-Binding Proteins / Q000235:genetics*; D004330:Drosophila; D029721:Drosophila Proteins / Q000235:genetics*; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D020868:Gene Silencing; D006657:Histones / Q000378:metabolism; D006801:Humans; D008745:Methylation; D008954:Models, Biological; D063150:Polycomb Repressive Complex 1; D012313:RNA / Q000737:chemistry; D014157:Transcription Factors / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D006657:Histones; C066770:Pc protein, Drosophila; D014157:Transcription Factors; C063460:Trl protein, Drosophila; D012313:RNA; D063150:Polycomb Repressive Complex 1