Mast cell-derived mediators of enhanced microvascular permeability, vascular permeability factor/vascular endothelial growth factor, histamine, and serotonin, cause leakage of macromolecules through a new endothelial cell permeability organelle, the vesiculo-vacuolar organelle.
Dvorak
Ann M
AM
Department of Pathology - East Campus, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. advorak@bidmc.harvard.edu
D000818:Animals; D002199:Capillary Permeability; D042783:Endothelial Cells / Q000378:metabolism*; D006632:Histamine / Q000378:metabolism*; D006801:Humans; D008407:Mast Cells / Q000378:metabolism* / Q000648:ultrastructure*; D009369:Neoplasms / Q000098:blood supply; D015388:Organelles / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D022161:Transport Vesicles / Q000378:metabolism*; D014617:Vacuoles / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000032:analysis
D042461:Vascular Endothelial Growth Factor A; D012701:Serotonin; D006632:Histamine; D040301:Vascular Endothelial Growth Factor Receptor-2