A pheochromocytoma causing limited coagulopathy with hemoptysis.
We treated a 59-year-old woman presenting with hemoptysis, a rare symptom of pheochromocytoma. Multiple factors including hypertension caused by sudden catecholamine release may result in pulmonary edema. It should be noted that the increased activation of coagulation cascade, which was demonstrated by increased thrombin-antithrombin III complex (TAT) and prothrombin fragment factor 1 and 2 (F1 + 2), as well as endothelial or platelet stimulation evidenced by the increased plasma von Willebrand factor, may have contributed to hemoptysis. These abnormalities were normalized after adrenalectomy. Our case indicates the important role of catecholamine in coagulopathy and possibly in vasculopathy.
Kimura
Yoko
Y
Institute of Oriental Medicine, Tokyo Women's Medical University School of Medicine, 2-4-1 Nishishin juku, Shin juku-ku, Tokyo 163-0804, Japan. ykimura@iom.twmu.ac.jp
Ozawa
Hideki
H
Igarashi
Mihoko
M
Iwamoto
Tomooki
T
Nishiya
Kenzo
K
Urano
Tetsuya
T
Goto
Shinya
S
D019797:3-Iodobenzylguanidine; D001778:Blood Coagulation Disorders / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology*; D001779:Blood Coagulation Factors / Q000378:metabolism; D002395:Catecholamines / Q000652:urine; D005260:Female; D006469:Hemoptysis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D010673:Pheochromocytoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology*; D011859:Radiography; D015898:Tomography Scanners, X-Ray Computed
D001779:Blood Coagulation Factors; D002395:Catecholamines; D019797:3-Iodobenzylguanidine