Levels of complexity in pathogen recognition by C-type lectins.
In pathogen recognition by C-type lectins, several levels of complexity can be distinguished; these might modulate the immune response in different ways. Firstly, the pathogen-associated molecular pattern repertoire expressed at the microbial surface determines the interactions with specific receptors. Secondly, each immune cell type possesses a specific set of pathogen-recognition receptors. Thirdly, changes in the cell-surface distribution of C-type lectins regulate carbohydrate binding by modulating receptor affinity for different ligands. Crosstalk between these receptors results in a network of multimolecular complexes, adding a further level of complexity in pathogen recognition.
Cambi
Alessandra
A
Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Figdor
Carl G
CG
D000818:Animals; D000941:Antigens / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D037181:Lectins, C-Type / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism
D000941:Antigens; D002241:Carbohydrates; D037181:Lectins, C-Type