Mapping postnatal mouse brain development with diffusion tensor microimaging.
While mouse brain development has been extensively studied using histology, quantitative characterization of morphological changes is still a challenging task. This paper presents how developing brain structures can be quantitatively characterized with magnetic resonance diffusion tensor microimaging coupled with techniques of computational anatomy. High resolution diffusion tensor images of ex vivo postnatal mouse brains provide excellent contrasts to reveal the evolutions of mouse forebrain structures. Using anatomical landmarks defined on diffusion tensor images, tissue level growth patterns of mouse brains were quantified. The results demonstrate the use of these techniques to three-dimensionally and quantitatively characterize brain growth.
Zhang
Jiangyang
J
Johns Hopkins University, School of Medicine, Department of Radiology, Division of NMR Research, 720 Rutland Avenue, Baltimore, MD 21205, USA.
Miller
Michael I
MI
Plachez
Celine
C
Richards
Linda J
LJ
Yarowsky
Paul
P
van Zijl
Peter
P
Mori
Susumu
S
D000465:Algorithms; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001921:Brain / Q000254:growth & development / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D003337:Corpus Callosum / Q000033:anatomy & histology / Q000254:growth & development / Q000502:physiology; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006624:Hippocampus / Q000033:anatomy & histology / Q000254:growth & development / Q000502:physiology; D007090:Image Interpretation, Computer-Assisted; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D019579:Neocortex / Q000033:anatomy & histology / Q000254:growth & development / Q000502:physiology