title: Familial Mediterranean fever and mesangial proliferative glomerulonephritis: report of a case and review of the literature.
abstract: In familial Mediterranean fever (FMF), a genetically inherited disease characterized by fever and serositis, renal involvement is mainly AA amyloidosis. We report a patient with FMF who developed mesangial proliferative glomerulonephritis; presumably in response to colchicine treatment, the activity of the disease decreased and renal function tests and urinary findings normalized. This report emphasizes the concurrent existence of mesangial proliferative glomerulonephritis with FMF in the absence of renal amyloidosis. Due to increased inflammatory response observed in FMF, immunologic glomerular injury, a common cause of glomerulonephritis, may occur more frequently in patients with FMF.
authors.affiliation: Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: Deniz N
authors.initials: DN
authors.lastname: Cagdas
authors.forename: Safak
authors.initials: S
authors.lastname: Gucer
authors.forename: Gülsev
authors.initials: G
authors.lastname: Kale
authors.forename: Ali
authors.initials: A
authors.lastname: Duzova
authors.forename: Seza
authors.initials: S
authors.lastname: Ozen
mesh_terms: D000293:Adolescent; D003078:Colchicine / Q000627:therapeutic use; D010505:Familial Mediterranean Fever / Q000150:complications*; D015432:Glomerulonephritis, Membranoproliferative / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D008297:Male; D012076:Renal Agents / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D012076:Renal Agents; D003078:Colchicine