[Increasing oxidative stress in aging].
The balance between reactive oxigen species (ROS) production and degradation is important in defining oxidative stress. In aging process, ROS production increases and degradation is impaired and thus oxidative stress is accumulated. Oxidative stress damages organs both directly and indirectly. Protein, lipid, as well as DNA are directly react with ROS, more over, ROS interact with intracellular signaling system. It is reported that several transcription factors such as NF-kappaB, AP-1 and ASK-1 and also it interferes MAPK activity. Besides these signaling, we recently showed that insulin resistance is induced by accumulated oxidative stress in aged mice. Adrenomedullin deficient mice accumulate higher oxidative stress and insulin resistance developed in aging. Oxidative stress in aging relates not only direct organ damage but also induce risk factors for vascular damage such as metabolic syndrome.
Shimosawa
Tatsuo
T
Department of Clinical Laboratory Medicine, The University of Tokyo.
D053607:Adrenomedullin; D000375:Aging / Q000502:physiology*; D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000209:etiology; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects / Q000235:genetics; D010455:Peptides / Q000494:pharmacology / Q000502:physiology / Q000627:therapeutic use; D017382:Reactive Oxygen Species / Q000378:metabolism; D012307:Risk Factors; D015398:Signal Transduction / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism
D010455:Peptides; D017382:Reactive Oxygen Species; D014157:Transcription Factors; D053607:Adrenomedullin; D020928:Mitogen-Activated Protein Kinases