title: Nonlinear control for algae growth models in the chemostat.
abstract: This paper deals with output feedback control of phytoplanktonic algae growth models in the chemostat. The considered class of model is of variable yield type, meaning that the ratio between the environmental nutrient absorption rate and the cells' growth rate varies, which is different from classical bioprocesses assumptions. On the basis of weak qualitative hypotheses on the analytical expressions of the involved biological phenomena (which guarantee robustness of the procedure toward modeling uncertainties) we propose a nonlinear controller and prove its ability to globally stabilize such processes. Finally, we illustrate our approach with numerical simulations and show its benefits for biological laboratory experiments, especially for ensuring persistence of the culture facing classical experimental problems.
authors.affiliation: Comore, Inria, BP93, 06902 Sophia-Antipolis cedex, France. ludovic.mailleret@inria.fr
authors.forename: L
authors.initials: L
authors.lastname: Mailleret
authors.forename: J-L
authors.initials: JL
authors.lastname: Gouzé
authors.forename: O
authors.initials: O
authors.lastname: Bernard
mesh_terms: D000465:Algorithms; D019149:Bioreactors / Q000382:microbiology*; D018929:Cell Culture Techniques / Q000379:methods*; D049109:Cell Proliferation; D003198:Computer Simulation; D056890:Eukaryota / Q000254:growth & development*; D005246:Feedback / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology; D007700:Kinetics; D008954:Models, Biological; D009584:Nitrogen / Q000378:metabolism; D017711:Nonlinear Dynamics; D009716:Numerical Analysis, Computer-Assisted; D010100:Oxygen / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D049490:Systems Biology / Q000379:methods
chemical_list: D009584:Nitrogen; D010100:Oxygen