title: Influence of the serotonin transporter promoter gene polymorphism on susceptibility to posttraumatic stress disorder.
abstract: Posttraumatic stress disorder (PTSD) is a prevalent anxiety disorder marked by behavioral, physiologic, and hormonal alterations. The etiology of PTSD is unknown, although exposure to a traumatic event constitutes a necessary, but not sufficient, factor. Serotonergic dysfunction has been implicated in PTSD. The present study examined the possible association between the serotonin-transporter-linked polymorphic region (SERTPR) and PTSD. The genotype and allele frequencies of the SERTPR were analyzed in 100 PTSD patients and 197 unrelated healthy controls using a case-control design. The frequency of the s/s genotype was significantly higher in PTSD patients than in normal controls. These findings suggest that the SERTPR s/s genotype is one of the genetic factors for the susceptibility to PTSD. Further investigations are required into the influence of gene polymorphisms on the biological mechanisms of PTSD, its clinical expression, and its response to treatment.
authors.affiliation: Department of Psychiatry and Depression Center, Korea University College of Medicine, Seoul, Korea.
authors.forename: Heon-Jeong
authors.initials: HJ
authors.lastname: Lee
authors.forename: Min-Soo
authors.initials: MS
authors.lastname: Lee
authors.forename: Rhee-Hun
authors.initials: RH
authors.lastname: Kang
authors.forename: Hyun
authors.initials: H
authors.lastname: Kim
authors.forename: Soon-Duck
authors.initials: SD
authors.lastname: Kim
authors.forename: Baik-Seok
authors.initials: BS
authors.lastname: Kee
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Kim
authors.forename: Yong-Ku
authors.initials: YK
authors.lastname: Kim
authors.forename: Jung Bum
authors.initials: JB
authors.lastname: Kim
authors.forename: Byung Kil
authors.initials: BK
authors.lastname: Yeon
authors.forename: Kang Seob
authors.initials: KS
authors.lastname: Oh
authors.forename: Byung-Hoon
authors.initials: BH
authors.lastname: Oh
authors.forename: Jin-Sang
authors.initials: JS
authors.lastname: Yoon
authors.forename: Chul
authors.initials: C
authors.lastname: Lee
authors.forename: Han Yong
authors.initials: HY
authors.lastname: Jung
authors.forename: Ik-Seung
authors.initials: IS
authors.lastname: Chee
authors.forename: In Ho
authors.initials: IH
authors.lastname: Paik
mesh_terms: D000328:Adult; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics* / Q000502:physiology; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics* / Q000502:physiology; D013313:Stress Disorders, Post-Traumatic / Q000235:genetics* / Q000503:physiopathology*
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins