[Control of the survival/apoptosis balance by E-cadherin: role in enterocyte anoikis].
Cadherins are transmembrane glycoproteins involved in cell-cell adherence. Recent developments indicate that classical cadherins may act as adherence-activated signaling receptors. Here, we review recent data from the literature concerning the role of classical cadherins in the control of cell survival and the signaling pathways involved. We focus on the fate and the role of E-cadherin, the main classical cadherin expressed in epithelial cells, in the cell death program triggered in enterocytes by loss of anchorage from the extracellular matrix (anoikis). These data open new perspectives on the key role of this protein, which is dysregulated in most carcinoma and is considered as a tumour-suppressor.
Fouquet
Stéphane
S
UMR 505 INSERM-UPMC, Laboratoire de Pharmacologie Cellulaire et Moléculaire de l'Ecole Pratique des Hautes Etudes, 15, rue de l'Ecole de Médecine, 75006 Paris, France.
Lugo-Martínez
Verónica-Haydée
VH
Chambaz
Jean
J
Cardot
Philippe
P
Pinçon-Raymond
Martine
M
Thenet
Sophie
S
D000818:Animals; D023102:Anoikis / Q000502:physiology*; D017209:Apoptosis / Q000502:physiology*; D015820:Cadherins / Q000502:physiology*; D002448:Cell Adhesion; D002470:Cell Survival / Q000502:physiology*; D020895:Enterocytes / Q000166:cytology* / Q000502:physiology*; D006706:Homeostasis; D006801:Humans
D015820:Cadherins