title: RNA interference libraries prove their worth in hunt for tumor suppressor genes.
abstract: RNA interference has been promoted as an ideal tool for functional genomics, but to date the success stories have principally been in model organisms. Two papers in this issue of Cell change all that: use of RNA interference libraries targeting large proportions of the human genome to uncover two novel tumor suppressor genes. REST is a transcriptional repressor that silences neuron-specific gene expression, and PITX1 is a homeodomain transcription factor that promotes the expression of a negative regulator of Ras.
authors.affiliation: Signal Transduction Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, United Kingdom.
authors.forename: Julian
authors.initials: J
authors.lastname: Downward
mesh_terms: D015723:Gene Library; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D023281:Genomics; D018398:Homeodomain Proteins / Q000235:genetics / Q000502:physiology; D006801:Humans; D051761:Paired Box Transcription Factors; D011401:Promoter Regions, Genetic; D034622:RNA Interference / Q000502:physiology*; D012097:Repressor Proteins / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology; D000099229:RE1-Silencing Transcription Factor
chemical_list: D018398:Homeodomain Proteins; D051761:Paired Box Transcription Factors; D012097:Repressor Proteins; D014157:Transcription Factors; D000099229:RE1-Silencing Transcription Factor; C101485:homeobox protein PITX1