title: Delayed visual decline in patients with "stable" optic neuropathy.
abstract: BACKGROUND
  Histological studies on the human optic nerve have documented decreasing axonal nerve fiber counts with age. In patients with optic atrophy, a nonpathological dropout of ganglion cell axons as part of the normal aging process may become clinically significant.
  
  
  OBJECTIVE
  To describe the occurrence of delayed visual loss in patients with presumably "stable" optic neuropathy.
  
  
  METHODS
  We reviewed the medical records of 3 patients who experienced slowly progressive visual loss in adulthood after suffering childhood optic nerve injury.
  
  
  RESULTS
  All 3 patients had a monophasic illness in childhood that caused bilateral optic atrophy and visual impairment. Following decades of stability, each suffered a gradual, symptomatic visual decline that extended over years. No new ophthalmologic, systemic, or neurologic disorder was found that explained the visual decline in any of these patients.
  
  
  CONCLUSIONS
  We hypothesize that the late visual decline in these 3 patients resulted from deleterious effects of age-related axonal loss on an already depleted population of neurons.
authors.affiliation: The Massachusetts Eye and Ear Infirmary and the Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
authors.forename: Jonathan W
authors.initials: JW
authors.lastname: Kim
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Rizzo
authors.forename: Simmons
authors.initials: S
authors.lastname: Lessell
mesh_terms: D017668:Age of Onset; D000368:Aged; D000375:Aging / Q000502:physiology; D001369:Axons / Q000473:pathology; D002452:Cell Count; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000150:complications* / Q000503:physiopathology; D012165:Retinal Ganglion Cells / Q000473:pathology; D014786:Vision Disorders / Q000150:complications* / Q000503:physiopathology; D014792:Visual Acuity