title: Reduction of right ventricular pacing in patients with sinus node dysfunction using an enhanced search AV algorithm.
abstract: BACKGROUND
  Dual chamber pacing typically results in a high percentage of ventricular pacing. A number of studies have been conducted suggesting detrimental effects of ventricular desynchronization produced by long-term RV pacing. Pacemaker algorithms that extend the AV interval to uncover intrinsic AV conduction have been utilized to reduce ventricular pacing. These algorithms are often limited to AV intervals below 250 ms limiting the ventricular pacing reduction. We hypothesized that by allowing AV intervals to extend beyond 300 ms, a marked reduction in RV pacing can be achieved.
  
  
  METHODS
  A total of 30 patients (17 men, mean age 71 +/- 9) with standard Brady indications, and implanted with a Medtronic Kappa 700 pacemaker, were randomized to 2-week treatments with default Search AV (KSAV) parameters or Enhanced Search AV (ESAV) parameters. The Enhanced Search AV algorithm included the capability for continuous adjustment of AV delays and the ability to auto disable in patients with persistent AV block.
  
  
  RESULTS
  Among patients with intact AV conduction, percent VP was greater in KSAV versus ESAV (70 +/- 40% vs 19 +/- 28%, P < 0.001). In patients with persistent AV block, the algorithm suspended appropriately and there was no significant change in the percent VP between both arms of the study. In 18/22 patients, percent VP was reduced below 40%.
  
  
  CONCLUSIONS
  Substantial reduction in ventricular pacing can be achieved by allowing the AV interval parameters to extend beyond 300 ms using the ESAV algorithm. In patients with AV block, ESAV suspended and patients were paced at their nominal settings.
authors.affiliation: Humboldt-Universität, Charité Hospital, Schumannstrasse 20/21, 10117 Berlin, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Melzer
authors.forename: Sameh
authors.initials: S
authors.lastname: Sowelam
authors.forename: Todd J
authors.initials: TJ
authors.lastname: Sheldon
authors.forename: H J
authors.initials: HJ
authors.lastname: Bondke
authors.forename: Gert
authors.initials: G
authors.lastname: Baumann
authors.forename: Bill
authors.initials: B
authors.lastname: Combs
authors.forename: Heinz
authors.initials: H
authors.lastname: Theres
mesh_terms: D000368:Aged; D000465:Algorithms; D002304:Cardiac Pacing, Artificial; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology; D006801:Humans; D008297:Male; D012804:Sick Sinus Syndrome / Q000503:physiopathology / Q000628:therapy*; D016278:Ventricular Function, Right