title: The benefit of participating to clinical research.
abstract: We assessed the impact of participating to clinical research among 1727 women with localized breast cancer. Using as referent individuals not treated according to guidelines for systemic therapy, the adjusted hazard ratio of death was 0.70 (95% confidence interval (CI): 0.54,0.90, p-value: 0.006) in those treated according to current guidelines and 0.45 (95% CI: 0.27,0.73, p-value: 0.001) in participants to research. Participation to clinical trials results in a substantial gain in survival.
authors.affiliation: Direction des Systèmes de Soins et Services, Institut National de Santé Publique du Québec, 4835 ave. Christophe-Colomb, Qc, Montréal H2J 3G8, Canada. Nocole.Hebert-Croteau@Ins-pq.qc.ca
authors.forename: N
authors.initials: N
authors.lastname: Hébert-Croteau
authors.forename: J
authors.initials: J
authors.lastname: Brisson
authors.forename: J
authors.initials: J
authors.lastname: Lemaire
authors.forename: J
authors.initials: J
authors.lastname: Latreille
mesh_terms: D035843:Biomedical Research / Q000706:statistics & numerical data*; D001943:Breast Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000628:therapy; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D015996:Survival Rate; D016896:Treatment Outcome