title: The factor V Leiden and the G20210A prothrombin gene mutations are rare in women with fetal death.
abstract: OBJECTIVE
  To determine if there is an association between two commonly inherited thrombophilias, the factor V Leiden and the G20210A prothrombin mutations, and fetal death.
  
  
  METHODS
  We used a case-control study design to compare the frequencies of these mutations in women with fetal death and controls. Fetal death was the intrauterine death of the conceptus > or =10 weeks gestation. Controls had one live birth, no miscarriages, and no fetal death. Results were compared using chi square analysis.
  
  
  RESULTS
  One hundred and seventy-five cases and controls were identified. There were 4.6% of cases and 3.8% of controls heterozygous for the factor V Leiden mutation (NS), and 1.3% of cases and 1.7% of controls heterozygous for the prothrombin mutation (NS).
  
  
  CONCLUSIONS
  In our population, neither the factor V Leiden nor the G20210A prothrombin mutations are associated with fetal death. Further evidence is required before routine screening for these mutations can be recommended.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA. amy.sullivan@hsc.utah.edu
authors.forename: Amy E
authors.initials: AE
authors.lastname: Sullivan
authors.forename: Lesa
authors.initials: L
authors.lastname: Nelson
authors.forename: Juhree A
authors.initials: JA
authors.lastname: Rice
authors.forename: T Flint
authors.initials: TF
authors.lastname: Porter
authors.forename: D Ware
authors.initials: DW
authors.lastname: Branch
authors.forename: Robert M
authors.initials: RM
authors.lastname: Silver
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D005165:Factor V / Q000235:genetics*; D005260:Female; D005313:Fetal Death / Q000235:genetics*; D005998:Glycine / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D009154:Mutation / Q000235:genetics*; D011247:Pregnancy; D011516:Prothrombin / Q000235:genetics*
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D005998:Glycine