title: Endometrial effects, bleeding control, and compliance with a new postmenopausal hormone therapy regimen based on transdermal estradiol gel and every-other-day vaginal progesterone in capsules: a 3-year pilot study.
abstract: In a 3-year prospective study, 30 postmenopausal women received transdermal E2 gel and every-other-day vaginal P in capsules. At study completion, endometrial thickness was significantly reduced as compared with baseline (2.7 +/- 0.5 vs. 3.4 +/- 0.9 mm), endometrial biopsy showed endometrial atrophy in all cases, and amenorrhea was achieved in 92.6% of cycles, while excellent patient satisfaction was achieved.
authors.affiliation: 1st Institute of Gynecology and Obstetrics, University of Bari, Policlinico, Piazza Giulio Cesare, Bari, Italy. cicinelli@gynecology1.uniba.it
authors.forename: Ettore
authors.initials: E
authors.lastname: Cicinelli
authors.forename: Dominique
authors.initials: D
authors.lastname: de Ziegler
authors.forename: Raffaello
authors.initials: R
authors.lastname: Alfonso
authors.forename: Roberto
authors.initials: R
authors.lastname: Nicoletti
authors.forename: Marina
authors.initials: M
authors.lastname: Bellavia
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Colafiglio
mesh_terms: D000279:Administration, Cutaneous; D000282:Administration, Intravaginal; D002214:Capsules; D004334:Drug Administration Schedule; D004717:Endometrium / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D004958:Estradiol / Q000008:administration & dosage*; D015914:Estrogen Replacement Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010349:Patient Compliance / Q000706:statistics & numerical data; D010865:Pilot Projects; D011374:Progesterone / Q000008:administration & dosage*; D011446:Prospective Studies; D014592:Uterine Hemorrhage / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D002214:Capsules; D011374:Progesterone; D004958:Estradiol