title: A solid-phase approach to novel purine and nucleoside analogs.
abstract: This paper describes a method for the preparation of purine analogs using the solid-phase approach. Nucleoside bases were constructed on Merrifield resin by sequential displacement of purine dichloride with amines, and after detachment, the purine analogs were condensed with d,l-ribofuranoside compounds by the Vorbrüggen method. Thereof, l-ribofuranoside was prepared from l-arabinose via the selective oxidation-reduction procedure of the 2-OH group. Some compounds exhibited moderate activity against HIV-1 in PBM cells.
authors.affiliation: Henan Key Laboratory of Fine Chemicals, Zhengzhou 450002, PR China. jbchang@public2.zz.ha.cn
authors.forename: Junbiao
authors.initials: J
authors.lastname: Chang
authors.forename: Chunhong
authors.initials: C
authors.lastname: Dong
authors.forename: Xiaohe
authors.initials: X
authors.lastname: Guo
authors.forename: Weidong
authors.initials: W
authors.lastname: Hu
authors.forename: Senxiang
authors.initials: S
authors.lastname: Cheng
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.forename: Rongfeng
authors.initials: R
authors.lastname: Chen
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D019380:Anti-HIV Agents; D009705:Nucleosides; D011687:Purines; C030985:purine