title: Tetracycline fibers as an adjunct in the treatment of nifedipine-induced gingival enlargement.
abstract: BACKGROUND
  The hypothesis that nifedipine-induced gingival enlargement in periodontitis patients can be treated with the adjunctive use of tetracycline (TCN) fibers was tested in this study.
  
  
  METHODS
  Ten patients (mean age 66 +/- 4 years) with chronic periodontitis combined with nifedipine-induced gingival enlargement participated. Full mouth recordings of clinical parameters (probing depth, clinical attachment level, bleeding on probing, presence or absence of plaque) were assessed at baseline and gingival enlargement was estimated from casts. Participants were instructed in proper oral hygiene and received supragingival scaling before being reassessed 1 month later. They subsequently received full-mouth scaling and root planing followed by the immediate placement of TCN fibers in all pockets >5 mm. Clinical parameters were reassessed at 3, 6, and 12 months after completion of treatment.
  
  
  RESULTS
  TCN fiber placement was well tolerated by patients. All clinical parameters recorded displayed significant improvements after treatment, and they were preserved for the 12-month experimental period. A significant reduction of the percentage of pockets >5 mm was noticed after treatment. The reduction of enlargement was still observed at 12 months despite patients not achieving optimal oral hygiene.
  
  
  CONCLUSIONS
  Placement of tetracycline fibers as an adjunct to mechanical treatment is an option for the non-invasive therapy of nifedipine-induced gingival enlargement in periodontitis patients whose general medical condition and concomitant ailments do not favor a surgical approach.
authors.affiliation: Department of Preventive Dentistry, Periodontology and Implant Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece. dimisak@med.auth.gr
authors.forename: Dimitra
authors.initials: D
authors.lastname: Sakellari
authors.forename: Ioannis D
authors.initials: ID
authors.lastname: Vouros
authors.forename: Elena
authors.initials: E
authors.lastname: Aristodemou
authors.forename: Antonis B
authors.initials: AB
authors.lastname: Konstantinidis
authors.forename: Sigmund
authors.initials: S
authors.lastname: Socransky
authors.forename: Max
authors.initials: M
authors.lastname: Goodson
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000009:adverse effects; D019214:Gingival Overgrowth / Q000139:chemically induced / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009543:Nifedipine / Q000009:adverse effects; D010518:Periodontitis / Q000188:drug therapy*; D013752:Tetracycline / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D002121:Calcium Channel Blockers; D013752:Tetracycline; D009543:Nifedipine