Determinants of circulating adiponectin in women with polycystic ovary syndrome.
OBJECTIVE
Adiponectin is regarded as a possible link between adiposity and insulin resistance. Ghrelin and leptin are considered as signals of energy status. We evaluated the relationships between these peptides, androgens and insulin sensitivity in women affected by polycystic ovary syndrome.


METHODS
Thirty-six women with PCOS were examined with euglycemic hyperinsulinemic clamp (to determine M/I, index of insulin sensitivity). Leptin, ghrelin, adiponectin, androgens, and SHBG were determined. Statistics was done using correlation analysis and backward stepwise multiple regression.


RESULTS
The positive correlation of adiponectin with testosterone remains significant even after adjustment for BMI (p = 0.01), M/I (p = 0.009) and for both M/I and BMI (p = 0.02). In multiple regression with testosterone, M/I, leptin and ghrelin as independent variables, the model including testosterone (p = 0.03) and ghrelin (p = 0.002) explained 49% of the variability (p < 0.0012) of adiponectin.


CONCLUSIONS
Both adiponectin and ghrelin can be involved in the pathophysiology of PCOS but their relation must be delineated further.
Vrbíková
Jana
J
Institute of Endocrinology, Prague, Czech Republic. jvrbikova@endo.cz
Dvoráková
Katerina
K
Hill
Martin
M
Vcelák
Josef
J
Stanická
Sona
S
Vanková
Markéta
M
Srámková
Daniela
D
Vondra
Karel
K
Bendlová
Bela
B
Stárka
Luboslav
L
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000728:Androgens / Q000097:blood; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D005260:Female; D054439:Ghrelin; D015309:Glucose Clamp Technique; D006801:Humans; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood; D008875:Middle Aged; D036361:Peptide Hormones / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000453:epidemiology; D012044:Regression Analysis; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood
D052242:Adiponectin; D000728:Androgens; D015415:Biomarkers; D054439:Ghrelin; D020738:Leptin; D036361:Peptide Hormones; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone