Identification of aminopiperidine benzamides as MCHr1 antagonists.
The identification of a novel series of benzamide-containing MCHr1 antagonists is described. Compound 22 displayed moderate efficacy in a diet induced obesity mice model.
Vasudevan
Anil
A
Metabolic Diseases Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA. anil.vasudevan@abbott.com
Verzal
Mary K
MK
Wodka
Derek
D
Souers
Andrew J
AJ
Blackburn
Christopher
C
Che
Jennifer Lee
JL
Lai
Sujen
S
Brodjian
Sevan
S
Falls
Doug H
DH
Dayton
Brian D
BD
Govek
Elizabeth
E
Daniels
Tom
T
Geddes
Brad
B
Marsh
Kennan C
KC
Hernandez
Lisa E
LE
Collins
Christine A
CA
Kym
Philip R
PR
D000284:Administration, Oral; D000818:Animals; D019440:Anti-Obesity Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001549:Benzamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001667:Binding, Competitive; D004195:Disease Models, Animal; D004285:Dogs; D051379:Mice; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D017481:Receptors, Somatostatin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship; D013997:Time Factors
D019440:Anti-Obesity Agents; D001549:Benzamides; D010880:Piperidines; D017481:Receptors, Somatostatin