A simple in vivo atrial fibrillation model of rat induced by transesophageal atrial burst pacing.
A simple in vivo closed-chest atrial fibrillation (Af) model of rats was developed. Af was reproducibly induced by transesophageal atrial burst pacing for 30 s in each of the pentobarbital-anesthetized rats, whereas the cardiohemodynamic condition as well as the inducibility and duration of Af episode was stable over time. Moreover, the anti-Af effect of the class Ic drug pilsicainide was confirmed in this model, which was essentially the same as those reported previously in other Af animal models and clinical practice. Thus, this new model may become an alternative to current techniques.
Sugiyama
Atsushi
A
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Japan. atsushis@yamanashi.ac.jp
Takahara
Akira
A
Honsho
Sachiko
S
Nakamura
Yuji
Y
Hashimoto
Keitaro
K
D000818:Animals; D001281:Atrial Fibrillation / Q000209:etiology*; D002304:Cardiac Pacing, Artificial; D004195:Disease Models, Animal; D004562:Electrocardiography; D008012:Lidocaine / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D008012:Lidocaine; C042288:pilsicainide