Body fat redistribution after weight gain in women with anorexia nervosa.
BACKGROUND
Body image distortions are a core feature of anorexia nervosa (AN). Increasing evidence suggests that the fat distribution immediately after weight restoration in patients with AN differs from the distribution typical of healthy adult women.


OBJECTIVE
The purpose of this study was to assess body fat distribution before and shortly after normalization of weight in women with AN.


METHODS
Body composition and fat distribution were assessed by anthropometry, dual-energy X-ray absorptiometry, and whole-body magnetic resonance imaging in 29 women with AN before and after weight normalization and at a single time point in 15 female control subjects. Hormone concentrations were also evaluated in patients and control subjects.


RESULTS
During approximately 10.1 +/- 2.9 wk (range: 4-17.3 wk) of treatment, patients with AN gained 12.2 +/- 3.6 kg, and refed weight (54.1 +/- 4.2 kg) did not differ significantly from that of control subjects (54.7 +/- 4.4 kg). Waist-to-hip circumference ratio (P < 0.006), total trunk fat (P < 0.003), visceral adipose tissue (P < 0.006), and intramuscular adipose tissue (P < 0.003) were significantly greater in the weight-recovered patients than in the control subjects. In contrast, after refeeding, total subcutaneous adipose tissue and skeletal muscle mass did not differ significantly between the patients and control subjects. In patients with AN, serum cortisol decreased and serum estradiol increased significantly with refeeding but not to control concentrations.


CONCLUSIONS
In women with AN, normalization of weight in the short term is associated with an abnormal distribution of body fat. The implications of these findings for the long-term psychological and physical health of women with AN are unknown.
Mayer
Laurel
L
Department of Psychiatry, Columbia University, New York, NY, USA. lsm16@columbia.edu
Walsh
B Timothy
BT
Pierson
Richard N
RN
Heymsfield
Steven B
SB
Gallagher
Dympna
D
Wang
Jack
J
Parides
Michael K
MK
Leibel
Rudolph L
RL
Warren
Michelle P
MP
Killory
Erin
E
Glasofer
Deborah
D
D015502:Absorptiometry, Photon; D000273:Adipose Tissue / Q000254:growth & development*; D000328:Adult; D000856:Anorexia Nervosa / Q000097:blood / Q000503:physiopathology* / Q000628:therapy; D000886:Anthropometry; D001823:Body Composition / Q000502:physiology*; D016022:Case-Control Studies; D004958:Estradiol / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D013997:Time Factors; D015430:Weight Gain / Q000502:physiology*
D004958:Estradiol; D006854:Hydrocortisone