Infertility-related stress in men and women predicts treatment outcome 1 year later.
OBJECTIVE
To examine the separate and joint effects of male and female fertility problem (FP) stress and the source of stress (e.g., personal, social, marital) on treatment outcome.


METHODS
Prospective, epidemiological cohort design.


METHODS
Fertility clinics in Denmark.


METHODS
Eight hundred eighteen couples who were about to begin a new course of treatment.


METHODS
An FP stress inventory was administered at the start of treatment, and the treatment outcome was evaluated 12 months later.


METHODS
Number of treatment cycles in 12-month study period and treatment outcome (i.e., success, no success).


RESULTS
Fertility problem stress was associated with a poorer treatment outcome in women (pooled within-groups [WGr] correlation,WGr = .517) and men (WGr = .392) with the effect significantly more pronounced for women (z = 3.19, P<.001). Fertility problem stress arising in the personal and marital domain showed greater associations with treatment outcome than did FP stress from the social domain. Logistic regression indicated that women who reported more marital distress required more treatment cycles to conceive (median 3) than women reporting less marital distress (median 2) (odds ratio [OR] = 1.20: Model chi2(3) = 77.21, P<.001).


CONCLUSIONS
The findings provide evidence that infertility-related stress has direct and indirect effects on treatment outcome.
Boivin
Jacky
J
School of Psychology, Cardiff University, Cardiff, Wales, United Kingdom. boivin@cardiff.ac.uk
Schmidt
Lone
L
D000328:Adult; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000453:epidemiology / Q000523:psychology* / Q000628:therapy*; D007248:Infertility, Male / Q000453:epidemiology / Q000523:psychology* / Q000628:therapy*; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011446:Prospective Studies; D013315:Stress, Psychological / Q000453:epidemiology / Q000523:psychology*; D017211:Treatment Failure; D016896:Treatment Outcome