Histone modifications: from genome-wide maps to functional insights.
A large number of histone modifications has been implicated in the regulation of gene expression. Together, these modifications have the potential to form a complex combinatorial regulatory code. Genome-wide mapping approaches provide new opportunities to decipher this code, but they may suffer from systematic biases. Integration of datasets and improved technologies will provide the way forward.
van Leeuwen
Fred
F
Netherlands Cancer Institute, Plesmanlaan 121,1066 CX Amsterdam, The Netherlands.
van Steensel
Bas
B
D000107:Acetylation; D000818:Animals; D005786:Gene Expression Regulation; D016678:Genome / Q000235:genetics*; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009707:Nucleosomes / Q000235:genetics / Q000378:metabolism
D006657:Histones; D009707:Nucleosomes