Synthesis and biological evaluation of novel 1,4-naphthoquinone derivatives as antibacterial and antiviral agents.
A series of 1,4-naphthoquinone derivatives were synthesized and evaluated for antibacterial and antiviral activities. The structure-activity relationships of these compounds were also studied. The results suggest that compounds 9-22 showed in vitro marked antibacterial activity. Compounds 4c and 7a showed inhibitory effect against RNA dependent RNA polymerase induced poliovirus type 2 infected HeLa cells.
Tandon
Vishnu K
VK
Department of Chemistry, Lucknow University, Lucknow 226007, India. vishnutandon@yahoo.co.in
Yadav
Dharmendra B
DB
Singh
Ravindra V
RV
Vaish
Meenu
M
Chaturvedi
Ashok K
AK
Shukla
Praveen K
PK
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009285:Naphthoquinones / Q000138:chemical synthesis / Q000494:pharmacology; D017955:Poliovirus / Q000187:drug effects; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D009285:Naphthoquinones; D012324:RNA-Dependent RNA Polymerase; C035342:1,4-naphthoquinone