title: Refining an Alzheimer's vaccine to avoid an inflammatory response.
abstract: The utility of vaccine strategies to treat neurodegenerative diseases such as Alzheimer's disease may still hold promise. Phase IIa clinical trials were halted due to a small but significant occurrence of meningoencephalitis. Knowledge gained from studies on amyloid-beta peptide (Abeta) immunotherapy will allow optimisation of new-generation vaccines, targeting highly specific epitopes while reducing undesired side effects. In harnessing and steering the immune system, an effective response can be generated against Abeta, one that might have attenuated immune responses with robust disease-altering activity.
authors.affiliation: Centre for Research in Neurodegenerative Diseases, University of Toronto, Tanz Neuroscience Building, 6 Queen's Park Crescent West, Toronto, Ontario, M5S 3H2, Canada.
authors.forename: Mary E
authors.initials: ME
authors.lastname: Brown
authors.forename: Kevin A
authors.initials: KA
authors.lastname: DaSilva
authors.forename: Joanne
authors.initials: J
authors.lastname: McLaurin
mesh_terms: D000544:Alzheimer Disease / Q000628:therapy*; D023582:Alzheimer Vaccines / Q000009:adverse effects / Q000276:immunology / Q000627:therapeutic use*; D016229:Amyloid beta-Peptides / Q000009:adverse effects / Q000276:immunology / Q000627:therapeutic use*; D000818:Animals; D002986:Clinical Trials as Topic; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007167:Immunotherapy / Q000639:trends*; D008590:Meningoencephalitis / Q000209:etiology; D010446:Peptide Fragments / Q000009:adverse effects / Q000276:immunology
chemical_list: C437846:AN-1792; D023582:Alzheimer Vaccines; D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42)