title: [Clinical value of esophageal mucosal iodine stain during esophagoscopy for patients without swallowing symptoms].
abstract: OBJECTIVE
  To investigate the clinical value of esophageal mucosal iodine stain during esophagoscopy for patients with early esophageal carcinoma or precancerous lesions without swallowing symptoms, through analyzing the correlation between endoscopic findings and pathological results of biopsy on the suspicious spots.
  
  
  METHODS
  For 366 patients examined by iodine stain during esophagoscopy, the position, size, shape and boundary of all visible unstained lesions were recorded and multiple biopsies were taken on the unstained spots.
  
  
  RESULTS
  Before iodine stain, 462 lesions had been discovered in 366 patients. However, 478 abnormal lesions stained in 341 patients were detected after iodine stain, the remaining 25 gave no abnormal findings. More than 1/3 of patients were found to have more than 2 abnormally stained lesions. 28.4% of them (104 cases) had moderate or severe dysplasia or early esophageal cancer. The sensitivity of iodine stain in this series was 89.8%.
  
  
  CONCLUSIONS
  Iodine stain is very useful in detecting occult early esophageal carcinoma and precancerous lesions. The degree of coloration and the margin of suspicious spots are closely correlated with the pathological results.
authors.affiliation: Department of Endoscopy, Fourth Hospital, Hebei Medical University, Shijiazhuang 050011, China. guocarol@inhe.net
authors.forename: Xiao-qing
authors.initials: XQ
authors.lastname: Guo
authors.forename: Shi-jie
authors.initials: SJ
authors.lastname: Wang
authors.forename: Li-wei
authors.initials: LW
authors.lastname: Zhang
authors.forename: Ming-li
authors.initials: ML
authors.lastname: Wu
authors.forename: Yan-feng
authors.initials: YF
authors.lastname: Liu
authors.forename: Yang
authors.initials: Y
authors.lastname: Gao
authors.forename: Shun-ping
authors.initials: SP
authors.lastname: Wang
authors.forename: Ying-sai
authors.initials: YS
authors.lastname: Li
authors.forename: Li-mian
authors.initials: LM
authors.lastname: Er
authors.forename: Qing-wen
authors.initials: QW
authors.lastname: Cong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis; D004938:Esophageal Neoplasms / Q000175:diagnosis*; D004945:Esophagoscopy / Q000379:methods*; D004947:Esophagus / Q000473:pathology*; D005260:Female; D006801:Humans; D007455:Iodine; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology*; D011230:Precancerous Conditions / Q000175:diagnosis; D013194:Staining and Labeling
chemical_list: D007455:Iodine