Cross talk of signaling and apoptotic cascades in the CNS: target for virus modulation.
Signaling cascades that regulate proliferation, differentiation and apoptosis determine cell life and death decisions. All are targets of virus modulation. These cascades are briefly described in this review, underscoring cross talk and the integration of distinct signals that contribute to central nervous system (CNS) disease.
Aurelian
Laure
L
Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA. laurelia@umaryland.edu
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002470:Cell Survival; D002490:Central Nervous System / Q000473:pathology* / Q000821:virology*; D007426:Genes, Intracisternal A-Particle; D006801:Humans; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D014780:Viruses / Q000378:metabolism*
D019253:Proto-Oncogene Proteins c-bcl-2