title: Cytologic findings of spindle cell ductal carcinoma in situ of the breast: a case report.
abstract: BACKGROUND
  Ductal carcinoma in situ (DCIS), spindle cell type, is a rare and recently recognized entity in the breast. While the histologic features have been described in detail, no cytologic descriptions exist. We describe the cytologic and corresponding histologic findings in a case of spindle cell DCIS.
  
  
  METHODS
  A 35-year-old woman underwent fine needle aspiration (FNA) of a 1.5-cm, palpable mass. The aspirate showed predominantly clusters and a smaller population of single cells in a necrotic background. The cells were mostly spindled, The cells were mostly spindled, with a minor population of epithelioid cells. They had a high nuclear/cytoplasmic ratio, with hyperchromatic and pleomorphic nuclei that contained prominent nucleoli, altogether diagnostic of malignancy. Given the biphasic cell composition, a diagnosis of metaplastic carcinoma was favored and excision recommended; it showed spindle cell DCIS.
  
  
  CONCLUSIONS
  The cytologic features of spindle cell DCIS and metaplastic spindle cell carcinoma are similar and almost indistinguishable. Despite its rarity, spindle cell DCIS should be considered in the differential diagnosis of biphasic and spindle cell lesions in the breast.
authors.affiliation: Department of Pathology, Box 1194, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York 10029, usa. shabnam.jaffer@msnyuhealth.org
authors.forename: Shabnam
authors.initials: S
authors.lastname: jaffer
authors.forename: Patrick
authors.initials: P
authors.lastname: Emanuel
authors.forename: David
authors.initials: D
authors.lastname: Burstein
authors.forename: Alisan
authors.initials: A
authors.lastname: Goldfarb
mesh_terms: D000328:Adult; D044963:Biopsy, Fine-Needle; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology*; D002277:Carcinoma / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology*; D005260:Female; D006801:Humans