Study of electrochemical oxidation and determination of albendazole using a glassy carbon-rotating disk electrode.
In this work, electrochemical oxidation of albendazole (ABZ) was carried out using a glassy carbon-rotating disk electrode. Development of electroanalytical methodology for ABZ quantification in pharmaceutical formulations was also proposed by using linear sweep voltammetric technique. Electrochemical oxidation is observed for ABZ at E(1/2)=0.99 V vs. Ag/AgCl(sat), when an anodic wave is observed. Kinetic parameters obtained for ABZ oxidation exhibited a standard heterogeneous rate constant for the electrodic process equal to (1.51+/-0.07) x 10(-5) cm s(-1), with a alphan(a) value equal to 0.76. Limiting current dependence against ABZ concentration exhibited linearity on 5.0 x 10(-5) to 1.0 x 10(-2) mol l(-1) range, being obtained a detection limit of 2.4 x 10(-5) mol l(-1). Proposed methodology was applied to ABZ quantification in pharmaceutical formulations.
Santos
André L
AL
Departamento de Química Analítica, Instituto de Química, UNESP, Av. Prof. Francisco Degni s/n, CEP 14800-900 Araraquara, SP, Brazil.
Takeuchi
Regina M
RM
Mariotti
Marcela P
MP
De Oliveira
Marcelo F
MF
Zanoni
Maria V B
MV
Stradiotto
Nelson R
NR
D015766:Albendazole / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D004563:Electrochemistry; D004566:Electrodes; D005898:Glass; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000737:chemistry; D012399:Rotation
D004364:Pharmaceutical Preparations; D002244:Carbon; D015766:Albendazole