title: Dapsone syndrome with acute renal failure during leprosy treatment: case report.
abstract: Dapsone syndrome is a rare hypersensitivity reaction to dapsone and is characterized by high fever, papular or exfoliative dermatitis, progressing to liver toxicity and generalized lymphadenopathy, resembling a mononucleosis infection. We report a patient who developed acute renal failure, as well as other complications characteristic of dapsone syndrome, during leprosy treatment. Renal involvement had not been previously described as a dapsone syndrome feature.
authors.affiliation: Medical Clinics Department, Centre of Infectious Diseases and Tropical Diseases Research of Mato Grosso, Júlio Müller Hospital, Cuiabá, MT, Brazil.
authors.forename: Edson Nogueira
authors.initials: EN
authors.lastname: Alves-Rodrigues
authors.forename: Luciano Correa
authors.initials: LC
authors.lastname: Ribeiro
authors.forename: Margareth Dióz
authors.initials: MD
authors.lastname: Silva
authors.forename: Arley
authors.initials: A
authors.lastname: Takiuchi
authors.forename: Cor Jesus Fernandes
authors.initials: CJ
authors.lastname: Fontes
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D002991:Clofazimine / Q000008:administration & dosage; D003622:Dapsone / Q000008:administration & dosage / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000150:complications*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007917:Leprostatic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D007918:Leprosy / Q000188:drug therapy*; D012293:Rifampin / Q000008:administration & dosage; D013577:Syndrome
chemical_list: D007917:Leprostatic Agents; D003622:Dapsone; D002991:Clofazimine; D012293:Rifampin