IL-2 and TNF-alpha promoter polymorphisms in patients with acute kidney graft rejection.
BACKGROUND
Proinflammatory cytokines have been implicated in the pathogenesis of acute kidney allograft rejection. The aim of the study was to examine the association between interleukin (IL)-2 -330 and tumor necrosis factor (TNF)-alpha -308 promoter polymorphisms and acute kidney allograft rejection.


METHODS
The study included 72 patients with long-term stable graft function, and 57 diagnosed with acute kidney allograft rejection.


RESULTS
Patients with acute kidney allograft rejection showed a prevalence of subjects with TNF-alpha T2 allele (P < .05). The risk of acute kidney allograft rejection diagnosis was 2.5-fold greater among carriers of the T2 allele than those homozygous for T1T1 (OR 2.53, 95% CI 1.19 to 5.37, P < .05) There was no statistically significant difference in the distribution of IL-2 genotypes between patients with stable graft function and acute kidney allograft rejection.


CONCLUSIONS
The results suggest that TNF-alpha-308 promoter polymorphism is a risk factor for acute kidney allograft rejection.
Pawlik
A
A
Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, 70-111 Szczecin, Powst Wlkp 72, Poland. pawand@poczta.onet.pl
Domanski
L
L
Rozanski
J
J
Florczak
M
M
Dabrowska-Zamojcin
E
E
Dutkiewicz
G
G
Gawronska-Szklarz
B
B
D000208:Acute Disease; D006580:Genetic Carrier Screening; D005838:Genotype; D006084:Graft Rejection / Q000453:epidemiology* / Q000235:genetics*; D006085:Graft Survival / Q000235:genetics; D006720:Homozygote; D006801:Humans; D007376:Interleukin-2 / Q000235:genetics*; D016030:Kidney Transplantation / Q000276:immunology; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011401:Promoter Regions, Genetic; D017384:Sequence Deletion; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha