Translational control during mitosis.
Translation is now recognized as an important process in the regulation of gene expression. During the cell cycle, translation is tightly regulated. Protein synthesis is necessary for entry into and progression through mitosis and conversely, modifications of translational activity are observed during the cell cycle. This review focuses on translational control during mitosis (or M-phase) and the role of CDK1/cyclin B, the universal cell cycle regulator implicated in the G2/M transition, in protein synthesis regulation.
Le Breton
Magali
M
Equipe Cycle Cellulaire et Développement, UMR 7150 CNRS/UPMC, Station Biologique de Roscoff, BP 74, 29682 Roscoff cedex, France.
Cormier
Patrick
P
Bellé
Robert
R
Mulner-Lorillon
Odile
O
Morales
Julia
J
D016203:CDC2 Protein Kinase / Q000378:metabolism*; D002453:Cell Cycle / Q000235:genetics; D019926:Cyclin B / Q000378:metabolism*; D056744:Cyclin B1; D016195:G2 Phase / Q000235:genetics / Q000502:physiology; D005786:Gene Expression Regulation; D008938:Mitosis / Q000235:genetics* / Q000502:physiology; D010766:Phosphorylation; D026723:Polyadenylation; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism*
D019926:Cyclin B; D056744:Cyclin B1; D012333:RNA, Messenger; D016203:CDC2 Protein Kinase