Enhanced peptide beta-sheet affinity by metal to ligand coordination.
A histidine-coordinating metal complex substituted with methoxypyrrole amino acids (MOPAS) as a peptide beta-sheet binder shows high affinity for a H(2)N-His-Leu-Leu-Val-Phe-OMe pentapeptide in DMSO solution. Within the complex, a beta-sheet conformation is induced into the pentapeptide by weak intra-assembly interactions with the MOPAS units.
Kruppa
Michael
M
Institut für Organische Chemie, Universität Regensburg, Universitätsstrasse 31, D-93040 Regensburg, Germany.
Bonauer
Christoph
C
Michlová
Veronika
V
König
Burkhard
B
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry*; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D013237:Stereoisomerism
D000596:Amino Acids; C502154:H(2)N-His-Leu-Leu-Val-Phe-OMe; D008024:Ligands; D009842:Oligopeptides