title: Primary lymphoma of the skull base.
abstract: This case demonstrates the rare finding of a primary malignant lymphoma of the frontobasis and ethmoidal cells in a patient presenting with progressive loss of vision. Computed tomography and MRI demonstrated a homogenously enhancing tumour with extensive bony destructions of the skull base. After transsphenoidal biopsy, histology revealed a highly malignant primary B-cell lymphoma. The patient was further treated with immunochemotherapy. Tissue diagnosis is, therefore, crucial before a definitive therapy is instituted.
authors.affiliation: Department of Neurosurgery, University Hospital of the University of Technology, Aachen, Germany.
authors.forename: F J
authors.initials: FJ
authors.lastname: Hans
authors.forename: M H T
authors.initials: MH
authors.lastname: Reinges
authors.forename: K
authors.initials: K
authors.lastname: Nolte
authors.forename: P
authors.initials: P
authors.lastname: Reipke
authors.forename: T
authors.initials: T
authors.lastname: Krings
mesh_terms: D001706:Biopsy; D004358:Drug Therapy; D005260:Female; D006801:Humans; D007167:Immunotherapy; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D018714:Radiotherapy, Adjuvant; D019292:Skull Base Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D014057:Tomography, X-Ray Computed