The contribution of new findings and ideas to the old principles of teratology.
Although the last generally accepted concept of principles of teratology was issued more than 30 years ago, the cause of less than 50% of all congenital anomalies is known and no substantial change in their incidence has been observed worldwide. In the meantime, powerful techniques of molecular biology as well as many sophisticated preventive measures have been introduced with marginal effects on the overall birth defects numbers. In this paper, we follow the history of basic concepts of teratology starting with Isidore Geoffroy Saint-Hilaire and Dareste, followed in the 20th century by James Wilson. Since that time no bright and completely new idea, which would deserve the name principle, has emerged. The advanced molecular studies support the long-existing principles and disclose the great variability of individuals and their responses to adverse exposures. In this way, the future of teratology counseling may be seen in a deep analysis of any individual case.
Jelínek
Richard
R
Department of Histology and Embryology, Charles University 3rd Faculty of Medicine, Ruská 87, 100 00 Praha 10, Prague, Czech Republic. richard.jelinek@lf3.cuni.cz
D000328:Adult; D000818:Animals; D000013:Congenital Abnormalities / Q000209:etiology* / Q000235:genetics; D005260:Female; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008967:Molecular Biology; D011247:Pregnancy; D018570:Risk Assessment; D018600:Teratology / Q000266:history / Q000379:methods