Familial Mediterranean fever and mesangial proliferative glomerulonephritis: report of a case and review of the literature.
In familial Mediterranean fever (FMF), a genetically inherited disease characterized by fever and serositis, renal involvement is mainly AA amyloidosis. We report a patient with FMF who developed mesangial proliferative glomerulonephritis; presumably in response to colchicine treatment, the activity of the disease decreased and renal function tests and urinary findings normalized. This report emphasizes the concurrent existence of mesangial proliferative glomerulonephritis with FMF in the absence of renal amyloidosis. Due to increased inflammatory response observed in FMF, immunologic glomerular injury, a common cause of glomerulonephritis, may occur more frequently in patients with FMF.
Cagdas
Deniz N
DN
Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Gucer
Safak
S
Kale
Gülsev
G
Duzova
Ali
A
Ozen
Seza
S
D000293:Adolescent; D003078:Colchicine / Q000627:therapeutic use; D010505:Familial Mediterranean Fever / Q000150:complications*; D015432:Glomerulonephritis, Membranoproliferative / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D008297:Male; D012076:Renal Agents / Q000627:therapeutic use; D016896:Treatment Outcome
D012076:Renal Agents; D003078:Colchicine