Germinal centers still hold secrets.
There has been recent progress in understanding the mechanism of somatic hypermutation in germinal centers. By contrast, there is more theory than certainty about the way those cells that acquire heightened affinity for antigen are subsequently selected. Wang and Carter (2005) highlight this in the current issue of Immunity in a study of germinal center development in mice with impaired CD19 signaling.
MacLennan
Ian C M
IC
MRC Centre for Immune Regulation, University of Birmingham, United Kingdom.
D000818:Animals; D018941:Antigens, CD19 / Q000276:immunology / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology*; D018858:Germinal Center / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D027041:Somatic Hypermutation, Immunoglobulin / Q000276:immunology
D018941:Antigens, CD19