Anti-microbial activity and film characterization of thiazolidinone derivatives of chitosan.
Thiazolidinone derivatives (TDCs) were prepared by converting chitosan into chitosan's Schiff's bases (CSBs), followed by treatment with mercaptoacetic acid. Both CSBs and TDCs were tested for antimicrobial activity against four different bacteria. All TDCs showed comparatively better anti-microbial activity without much affecting basic physical properties of chitosan such as film-forming capacity, tensile strength, etc. This indicates that chitosan derivatives with a thiazolidinone moiety might be a better material for wound dressing.
Kulkarni
Anandrao R
AR
KLE'S College of Pharmacy, Hubli 580 031, India.
Kulkarni
Venktrao H
VH
Keshavayya
Jathi
J
Hukkeri
Vijaykumar I
VI
Sung
Hsing-Wen
HW
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D048271:Chitosan / Q000031:analogs & derivatives* / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D013844:Thiazoles; D048271:Chitosan