Deficient B lymphopoiesis in murine senescence: potential roles for dysregulation of E2A, Pax-5, and STAT5.
B lymphopoiesis in senescent mice is typically diminished and characterized by low pre-B cell numbers. The transcription factors E2A, Pax-5, and STAT5 have been implicated in the differentiation, proliferation, and survival of B cell precursors. In this review, we discuss the impairment of B lymphopoiesis during old age in the context of mechanisms at the molecular level responsible for the handling and turnover of these key transcriptional proteins. Alterations in the expression of E2A, Pax-5, and STAT5 may affect multiple stages of B cell development, contribute to reduced B lymphopoiesis, and preface changes in the "read-out" of the BCR repertoire during murine senescence.
Riley
Richard L
RL
Department of Microbiology and Immunology, University of Miami Leonard M. Miller School of Medicine, P.O. Box 016960 (R-138), Miami, FL 33101, USA. rriley@med.miami.edu
Van der Put
Elaine
E
King
Anne M
AM
Frasca
Daniela
D
Blomberg
Bonnie B
BB
D000375:Aging / Q000276:immunology*; D000818:Animals; D016175:B-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology*; D051792:Basic Helix-Loop-Helix Proteins / Q000502:physiology*; D016922:Cellular Senescence / Q000276:immunology*; D038041:Lymphopoiesis / Q000276:immunology*; D051379:Mice; D051757:PAX5 Transcription Factor / Q000502:physiology*; D050799:STAT5 Transcription Factor / Q000502:physiology*
D051792:Basic Helix-Loop-Helix Proteins; D051757:PAX5 Transcription Factor; D050799:STAT5 Transcription Factor; C497282:Pax5 protein, mouse; C075668:Tcf3 protein, mouse