title: [Relationship between serum vWF and PAF in type 2 diabetic patients and diabetic nephropathy].
abstract: OBJECTIVE
  To observe the changes in urine albumin (UALB), von Willebrand factor (vWF) and platelet-activating factor (PAF) in different courses of type 2 diabetes.
  
  
  METHODS
  Levels of UALB, vWF and PAF were determined in 30 type 2 diabetic nephropathy patients(group A), type 2 diabetic patients without DNP(group B, n=30), patients with impaired glucose tolerance (group C, n=30), the first-degree relatives of type 2 diabetic patients with normal glucose tolerance(group D, n=30) and 30 normal glucose tolerance subjects without family history of type 2 diabetes(group E).
  
  
  RESULTS
  UALB and PAF contents were significantly higher in group A than in the other groups (P<0.01), while between the latter 4 groups, the contents showed no significant differences (P>0.05). Serum vWF level was significantly higher in group A than those in the other groups (P<0.05).
  
  
  CONCLUSIONS
  Renal dysfunction and platelet activation are present in type 2 diabetes with microvascular complications, and the synchronized changes between renal dysfunction and platelet activation indicate the involvement of elevated PAF in vascular injury.
authors.affiliation: Second People's Hospital of Foshan City, Foshan 528000, China.
authors.forename: Yong-hong
authors.initials: YH
authors.lastname: Fang
authors.forename: Ji-ping
authors.initials: JP
authors.lastname: Zhang
authors.forename: Shao-xiong
authors.initials: SX
authors.lastname: Zhou
authors.forename: Ju-fen
authors.initials: JF
authors.lastname: Zheng
authors.forename: Yong-wei
authors.initials: YW
authors.lastname: Yu
authors.forename: Shi-gang
authors.initials: SG
authors.lastname: Yan
authors.forename: Wen-kui
authors.initials: WK
authors.lastname: Fan
authors.forename: Yue-song
authors.initials: YS
authors.lastname: Cheng
mesh_terms: D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003928:Diabetic Nephropathies / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010972:Platelet Activating Factor / Q000378:metabolism*; D014841:von Willebrand Factor / Q000378:metabolism*
chemical_list: D010972:Platelet Activating Factor; D014841:von Willebrand Factor