BCG modulation of anaphylactic antibody response, airway inflammation and lung hyperreactivity in genetically selected mouse strains (Selection IV-A).
The effect of Bacillus Calmette-Guérin (BCG) treatment in allergic pulmonary reaction was studied in mice genetically selected accordingly to a High (H-IVA) or Low (L-IVA) antibody responsiveness. Mice were immunized with ovalbumin (OVA) or OVA plus BCG. Two days after nasal antigenic challenge, seric IgE and IgG1 anti-OVA, eosinophils in pulmonary tissue, inflammatory cells in bronchoalveolar lavage and the compliance and conductance of respiratory system were evaluated. H-IVA mice were found more susceptible than L-IVA, and BCG was able to inhibit simultaneously the production of IgE, the bronchopulmonary inflammation and bronchial hyperresponsiveness in these genetically selected mice.
Barros
Myrthes Toledo
MT
Division of Clinical Immunology and Allergy, Heart Institute (InCor), Division of General Internal Medicine, Department of Medicine, University São Paulo, Av. Dr. Arnaldo, 455, Cerqueira César, 01246-903, São Paulo, Brazil. myrtb@uol.com.br
Acencio
Milena Marques Pagliarelli
MM
Garcia
Maria Lúcia Bueno
ML
Macedo Soares
Maria Fernanda
MF
Ibañez
Olga M
OM
Martins
Milton Arruda
MA
Ribeiro
Orlando Garcia
OG
Kalil
Jorge
J
Perini
Adenir
A
D000818:Animals; D001500:BCG Vaccine / Q000276:immunology*; D016535:Bronchial Hyperreactivity / Q000517:prevention & control*; D004797:Enzyme-Linked Immunosorbent Assay; D006967:Hypersensitivity / Q000517:prevention & control*; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007249:Inflammation / Q000517:prevention & control*; D007371:Interferon-gamma / Q000096:biosynthesis; D007962:Leukocytes / Q000502:physiology; D008168:Lung / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis / Q000276:immunology*; D051381:Rats; D011920:Rats, Inbred WF
D001500:BCG Vaccine; D007074:Immunoglobulin G; D007073:Immunoglobulin E; D007371:Interferon-gamma; D010047:Ovalbumin