title: Paradigm shift in NMDA receptor drug development.
abstract: Low-affinity, uncompetitive antagonists with rapid 'off-rates', such as memantine offer protection from dementia and other neurological disorders, but break all the old rules of screening for new drugs by high-affinity binding.
authors.forename: Stuart A
authors.initials: SA
authors.lastname: Lipton
authors.forename: H-S Vincent
authors.initials: HS
authors.lastname: Chen
mesh_terms: D004353:Drug Evaluation, Preclinical; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*
chemical_list: D018696:Neuroprotective Agents; D016194:Receptors, N-Methyl-D-Aspartate