[Experimental study on the effect of low molecular DNA from salmon milt in pseudotuberculosis infection].
The effect of low molecular DNA from salmon milt (nDNA) in experimental pseudotuberculosis in mice was studied. When nDNA was admiministered orally, dissemination of the organs by Yersinia pseudotuberculosis lowered and the survival of the animals infected with 100-percent lethal dose of the bacteria increased. nDNA decreased contamination of the epithelial cells by the microbe in vitro and prevented the lethal effect of the Y. pseudotuberculosis toxins on the mice.
Pavlinich
S N
SN
Logvinenko
A A
AA
Epshteĭn
L M
LM
Pokrovskiĭ
V K
VK
Kalenik
T K
TK
Timchenko
N F
NF
D000818:Animals; D002460:Cell Line; D015169:Colony Count, Microbial; D004247:DNA / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004847:Epithelial Cells / Q000187:drug effects / Q000382:microbiology; D008099:Liver / Q000382:microbiology; D051379:Mice; D008970:Molecular Weight; D012474:Salmon; D013154:Spleen / Q000382:microbiology; D015011:Yersinia pseudotuberculosis / Q000187:drug effects; D015012:Yersinia pseudotuberculosis Infections / Q000382:microbiology / Q000517:prevention & control*
D004247:DNA