TRAIL: at the center of drugable anti-tumor pathways.
Molecular analysis, in vivo and in vitro has identified TRAIL as a central component of anti-cancer networks in the cell. More recently, TRAIL has been shown to be involved in the selective apoptosis of AML cells by histone deacetylase inhibitors (HDACi). Here we summarize findings that the TRAIL pathway is a key factor in the apoptotic action of HDACi, as well as, retinoids and retinoid-combinations.
Clarke
Nicole
N
Department of Cell Biology and Signal Transduction, Institut de Génétique et de Biologie Moléculaire et Cellulaire/CNRS/INSERM/ULP, Illkirch Cedex, C. U. de Strasbourg, France.
Nebbioso
Angela
A
Altucci
Lucia
L
Gronemeyer
Hinrich
H
D051017:Apoptosis Regulatory Proteins / Q000378:metabolism*; D016923:Cell Death / Q000187:drug effects; D044127:Epigenesis, Genetic; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism*; D012176:Retinoids / Q000494:pharmacology; D053221:TNF-Related Apoptosis-Inducing Ligand; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D051017:Apoptosis Regulatory Proteins; D008562:Membrane Glycoproteins; D012176:Retinoids; D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human; D014409:Tumor Necrosis Factor-alpha; D006655:Histone Deacetylases