Strategies for cytosolic delivery of liposomal macromolecules.
Potential approaches to achieve cytosolic delivery of liposomal macromolecules are presented. These approaches include: (1) the co-encapsulation of fusogenic peptides into targeted drug-containing liposomes (2) coupling of the HIV-1-derived cell-penetrating peptide TAT to the surface of liposomes and (3) photochemical internalization, based on photochemically inducible permeabilization of endocytic vesicles.
Fretz
Marjan M
MM
Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands. M.M.Fretz@Pharm.uu.nl
Mastrobattista
Enrico
E
Koning
Gerben A
GA
Jiskoot
Wim
W
Storm
Gert
G
D002626:Chemistry, Pharmaceutical; D003600:Cytosol; D004337:Drug Carriers; D016503:Drug Delivery Systems; D015696:Gene Products, tat / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D008081:Liposomes; D010455:Peptides / Q000008:administration & dosage / Q000737:chemistry; D010777:Photochemistry
D004337:Drug Carriers; D015696:Gene Products, tat; D008081:Liposomes; D010455:Peptides