Cytokines as potential therapeutic targets for inflammatory skin diseases.
A network of pro-inflammatory cytokines is a central feature in the pathophysiology of cutaneous inflammatory diseases. Thus, the delineation of precise roles for particular cytokines and the development of cytokine-directed therapeutics have become areas of intense investigation. While anti-TNF therapeutics have proven to be effective for the treatment of psoriasis, clinical investigations have now begun with other cytokine-directed therapies, such as those targeting IFN-g, IL-12p40, and IL-18. In addition to therapeutics that target cytokines directly, strategies that target cytokine signaling pathways are in development too. In this short review, we summarize key findings from a recent workshop on cytokines as potential therapeutic targets for inflammatory skin diseases.
Numerof
Robert P
RP
RBA Dermatology USA, Berlex Biosciences, 2600 Hilltop Drive, PO Box 4099, Richmond, CA 94804-0099, USA. robert_numerof@berlex.com
Dinarello
Charles A
CA
Asadullah
Khusru
K
D002986:Clinical Trials as Topic; D016207:Cytokines / Q000502:physiology*; D003713:Dendritic Cells / Q000276:immunology; D003872:Dermatitis / Q000145:classification / Q000276:immunology / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology
D016207:Cytokines