title: Comparison of measurements of phase velocity in human calcaneus to Biot theory.
abstract: Biot's theory for elastic propagation in porous media has previously been shown to be useful for modeling the dependence of phase velocity on porosity in bovine cancellous bone in vitro. In the present study, Biot's theory is applied to measurements of porosity-dependent phase velocity in 53 human calcanea in vitro. Porosity was measured using microcomputed tomography for some samples (n = 23) and estimated based on bone mineral densitometry for the remaining samples (n = 30). The phase velocity at 500 kHz was measured in a water tank using a through-transmission technique. Biot's theory performed well for the prediction of the dependence of sound speed on porosity. The trend was quasilinear, but both the theory and experiment show similar slight curvature. The root mean square error (RMSE) of predicted versus measured sound speed was 15.8 m/s.
authors.affiliation: U.S. Food and Drug Administration, Center for Devices and Radiological Health, HFZ-140, 12720 Twinbrook Parkway, Rockville, Maryland 20852, USA. Kaw@cdrh.fda.gov
authors.forename: Keith A
authors.initials: KA
authors.lastname: Wear
authors.forename: Andres
authors.initials: A
authors.lastname: Laib
authors.forename: Angela P
authors.initials: AP
authors.lastname: Stuber
authors.forename: James C
authors.initials: JC
authors.lastname: Reynolds
mesh_terms: D001696:Biomechanical Phenomena; D002111:Calcaneus / Q000166:cytology*; D003720:Densitometry; D006801:Humans; D066298:In Vitro Techniques; D008954:Models, Biological; D016062:Porosity