The first hetero-bifunctionalization of the secondary face of beta-cyclodextrin: selective and efficient conversion of the A-ring of a 2A,2B-disulfonate to 2A,3A-epoxymannoside.
The A-ring of 2(A),2(B)-O,O-di(mesitylenesulfonyl)-beta-cyclodextrin was converted to 2(A),3(A)-epoxymannoside without affecting the other sulfonylated residue, which affords the first approach to hetero-bifunctionalization at the secondary hydroxyl side of cyclodextrins.
Fukudome
Makoto
M
Department of Molecular Medicinal Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Bunkyo-machi 1-14, Nagasaki 852-8521, Japan. fujita@net.nagasaki-u.ac.jp.
Sugimoto
Yuji
Y
Yuan
De-Qi
DQ
Fujita
Kahee
K
D008362:Mannosides / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D013451:Sulfonic Acids / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
D008362:Mannosides; D013451:Sulfonic Acids; D047392:beta-Cyclodextrins; C031215:betadex