The cochlear targets of cisplatin: an electrophysiological and morphological time-sequence study.
Cisplatin ototoxicity has at least three major targets in the cochlea: the stria vascularis, the organ of Corti, and the spiral ganglion. This study aims to differentiate between these three targets. In particular, we address the question of whether the effects at the level of the organ of Corti and spiral ganglion are mutually dependent or whether they develop in parallel. This question was approached by studying the ototoxic effects while they develop electrophysiologically and comparing these to earlier presented histological data [Van Ruijven et al., 2004. Hear. Res. 197, 44-54]. Guinea pigs were treated with intraperitoneal injections of cisplatin at a dose of 2 mg/kg/day for either 4, 6, or 8 consecutive days. This time sequence has not revealed any evidence of one ototoxic process triggering another. Therefore, we have to stay with the conclusion of Van Ruijven et al. (2004) that both processes run in parallel.
van Ruijven
Marjolein W M
MW
Hearing Research Laboratories, Department of Otorhinolaryngology, University Medical Center Utrecht, P.O. Box 85.500, 3508 GA Utrecht, The Netherlands. m.vanruijven@kmb.azu.nl
de Groot
John C M J
JC
Klis
Sjaak F L
SF
Smoorenburg
Guido F
GF
D000200:Action Potentials / Q000187:drug effects; D000704:Analysis of Variance; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000633:toxicity*; D001300:Audiometry, Evoked Response; D001309:Auditory Threshold; D002945:Cisplatin / Q000008:administration & dosage / Q000633:toxicity*; D003055:Cochlear Microphonic Potentials / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced* / Q000473:pathology; D007274:Injections, Intraperitoneal; D009925:Organ of Corti / Q000187:drug effects* / Q000503:physiopathology; D011897:Random Allocation; D013136:Spiral Ganglion / Q000187:drug effects* / Q000503:physiopathology; D013316:Stria Vascularis / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
D000970:Antineoplastic Agents; D002945:Cisplatin