title: Hemophagocytic syndrome after living-donor liver transplantation for fulminant liver failure: a case report.
abstract: Hemophagocytic syndrome (HPS) is a hypercytokinemia caused by activated T lymphocytes and macrophages in immunologically compromised patients. We report a 37-year-old female who was diagnosed with HPS after undergoing living-donor liver transplantation (LDLT) for fulminant liver failure of unknown etiology. After liver transplantation, recipients with pancytopenia should be tested for serum ferritin. When the serum ferritin is abnormal, the bone marrow should be biopsied to screen for HPS as soon as possible. If the condition is caught early and promptly treated, the outcome of this devastating condition might be improved. In addition, HPS should be ruled out in LDLT candidates with acute liver failure before their operations.
authors.affiliation: First Department of Surgery, Nippon Medical School, Tokyo, Japan. Taniain@nms.ac.jp
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Taniai
authors.forename: Koho
authors.initials: K
authors.lastname: Akimaru
authors.forename: Youichi
authors.initials: Y
authors.lastname: Kawano
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Mizuguchi
authors.forename: Tetuya
authors.initials: T
authors.lastname: Shimizu
authors.forename: Tsubasa
authors.initials: T
authors.lastname: Takahashi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Mamada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Takashi
authors.initials: T
authors.lastname: Tajiri
mesh_terms: D000328:Adult; D001706:Biopsy; D001707:Biopsy, Needle; D001853:Bone Marrow / Q000473:pathology; D016207:Cytokines / Q000097:blood; D003937:Diagnosis, Differential; D005260:Female; D005293:Ferritins / Q000097:blood; D006084:Graft Rejection / Q000175:diagnosis / Q000473:pathology; D006498:Hepatectomy; D006801:Humans; D008099:Liver / Q000473:pathology; D017114:Liver Failure, Acute / Q000601:surgery*; D008111:Liver Function Tests; D016031:Liver Transplantation; D019520:Living Donors; D008213:Lymphocyte Activation / Q000276:immunology; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis* / Q000276:immunology; D010976:Platelet Count; D011183:Postoperative Complications / Q000175:diagnosis* / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000097:blood; D012307:Risk Factors; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D016207:Cytokines; D015375:Receptors, Interleukin-2; D005293:Ferritins