title: Effect of the interaction between paranoxonase 1 and ATP-binding cassette transporter 1 gene polymorphism on serum lipid level.
abstract: OBJECTIVE
  To investigate the effect of interaction between paranoxonase 1 (PON1)gene polymorphism and ATP-binding cassette transporter 1 (ABCA1) genetic variation on serum lipid level.
  
  
  METHODS
  Polymerase chain reaction-restricted fragments length polymorphism was used to determine PON1 A/B192 and ABCA1R219K genotype of 1019 subjects, including 680 patients with strokes and 339 healthy individuals as controls.
  
  
  RESULTS
  No significant association between A/B192 genotype and any of the lipid measurements was detected. The levels of HDL-C in the subjects with RR, RK and KK genotypes showed a significant upward tendency respectively (P < 0.05); the levels of their triglyceride (TG) tended downward respectively, but there were no significant differences between them. The relationship between R219K genotype and serum lipid level was modified by A/B192 genotype. The levels of HDL-C in the subjects with AA/RR genotype and BB/KK genotype [(1.41 +/- 0.40) mmol/L, (1.41 +/- 0.39) mmol/L] were significantly different from that in the subjects with BB/RR genotype [(1.28 +/- 0.36) mmol/L] (P < 0.05).
  
  
  CONCLUSIONS
  The result exhibited an interaction of PON1 A/B192 and ABCA1 R219K on serum lipid level.
authors.affiliation: Department of Neurology, Xiangya Second Hospital, Central South University, Changsha, Hunan, 410011, PR China. xiaozhijie720@sina.com
authors.forename: Zhi-jie
authors.initials: ZJ
authors.lastname: Xiao
authors.forename: Shui-ping
authors.initials: SP
authors.lastname: Zhao
authors.forename: Sai
authors.initials: S
authors.lastname: Nie
authors.forename: Li-min
authors.initials: LM
authors.lastname: Tan
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000368:Aged; D043303:Aryldialkylphosphatase / Q000235:genetics*; D001483:Base Sequence; D005260:Female; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D017422:Sequence Analysis, DNA
chemical_list: D018528:ATP-Binding Cassette Transporters; D008055:Lipids; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human