[Clinical analysis of 91 cases of hereditary breast and ovarian cancer].
OBJECTIVE
To explore the clinical characteristics of ovarian cancer in hereditary breast/ovarian cancer.


METHODS
Ninety-one cases of hereditary breast/ovarian cancer were analyzed in terms of age, histological features, stage, familial history, survival time and prognostic factors by SPSS statistical software.


RESULTS
The overall median survival time of the patients was 47 months, and the 2-and 5-year survival rates were 71.2% and 33.5%, respectively. The median age at diagnosis of ovarian cancer was 52 years with the majority of patients (60.4%) diagnosed before 55. Among 39 cases with double primary cancers, there are 20 cases (51.3%) with interval no less than 60 months. The most frequent histological types of ovarian cancer is serous adeno-carcinoma (59.3%). Most patients were in stage III or IV (76.9%) with poor differentiation (59.3%).


CONCLUSIONS
The age of diagnosis in ovarian cancer in patients with hereditary breast/ovarian cancer is earlier than that of sporadic ones. Most of the cases were advanced with poor differentiation. Stage and differentiation are the prognostic factors. In patients with double primary cancers, the clinical pathological characteristics of ovarian cancer had the main effect on their prognosis. The survival of hereditary ovarian cancer is similar to that of sporadic ones.
Li
Ning
N
Department of Medical Oncology, Cancer Institute (hospital), Chinese Academy of Medical Sciences, Peking Union Medical Collage, Beijing 100021, China.
Wu
Ling-ying
LY
Zhang
Rong
R
Zhang
Xin
X
Liu
Li-ying
LY
D001943:Breast Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D018284:Cystadenocarcinoma, Serous / Q000235:genetics / Q000401:mortality; D005192:Family Health; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D015996:Survival Rate