title: Neutropenic enterocolitis in lung cancer: a report of two cases and a review of the literature.
abstract: The first patient, a 68-year-old woman, presented neutropenic fever and hemorrhagic diarrhea on the sixth day of a combination chemotherapy of carboplatin and paclitaxel. The second patient, a 30-year-old man, presented neutropenia and diarrhea on the tenth day of the second cycle of a combination chemotherapy of cisplatin and vinorelbine. In both patients, abdominal computed tomography scan showed thickening of the colon wall and pericolic edema, and the ultrasonography revealed echogenic thickening of the colon walls. These findings confirmed the diagnosis of neutropenic enterocolitis. After the treatments, we changed the anticancer drug regimen; and successfully achieved partial responses.
authors.affiliation: Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Furonaka
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Masamistu
authors.initials: M
authors.lastname: Nakajima
authors.forename: Shintaro
authors.initials: S
authors.lastname: Hirata
authors.forename: Kazunori
authors.initials: K
authors.lastname: Fujitaka
authors.forename: Keiichi
authors.initials: K
authors.lastname: Kondo
authors.forename: Akihito
authors.initials: A
authors.lastname: Yokoyama
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Maeda
authors.forename: Nobuoki
authors.initials: N
authors.lastname: Kohno
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003106:Colon / Q000000981:diagnostic imaging; D044504:Enterocolitis, Neutropenic / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents