6-Aryl-4-methylsulfanyl-2H-pyran-2-one-3-carbonitriles as PPAR-gamma activators.
Various 6-aryl-3-cyano/methoxycarbonyl-4-methylsulfanyl-2H-pyran-2-ones have been synthesized as a potential substitute of 2,4-thiazolidinedione head group to express potent PPAR-gamma transactivation response. Some of the screened compounds have shown promising PPAR-gamma agonistic activity.
Sharon
Ashoke
A
Molecular and Structural Biology Division, Central Drug Research Institute, Lucknow 226001, India.
Pratap
Ramendra
R
Vatsyayan
Rit
R
Maulik
Prakas R
PR
Roy
Uma
U
Goel
Atul
A
Ram
Vishnu Ji
VJ
D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D047495:PPAR gamma / Q000819:agonists / Q000187:drug effects*; D011714:Pyrans / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D008024:Ligands; D009570:Nitriles; D047495:PPAR gamma; D011714:Pyrans