title: [Therapeutic effect of L-ornithine-L-aspartate on liver cirrhosis complicated by hepatic encephalopathy].
abstract: OBJECTIVE
  To observe the therapeutic effects of L-ornithine-L-aspartate on liver cirrhosis complicated by hepatic encephalopathy.
  
  
  METHODS
  Eighty-five patient with liver cirrhosis complicated by hepatic encephalopathy were divided into therapy group (n=45) and control group (n=40). Patients in the control group were treated with routine comprehensive therapy, and those in the therapy group received additional intravenous administration with 40 ml L-ornithine-L-aspartate in 250 ml 10% glucose and saline (once daily, 7 days for a treatment course).
  
  
  RESULTS
  L-ornithine-L-aspartase significantly decreased blood ammonia and improved hepatic function (P<0.05 or 0.01). The therapeutic effects of therapy group was better than that of the control group (P<0.05), and no significant side effect was observed in L-ornithine-L-aspartate treatment.
  
  
  CONCLUSIONS
  L-ornithine-L-aspartate is effective for hepatic encephalopathy and has not obvious side effect.
authors.affiliation: Department of Infectious Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China. xiaotian151@yahoo.com.cn
authors.forename: Ming-fei
authors.initials: MF
authors.lastname: Chen
authors.forename: Ru-cheng
authors.initials: RC
authors.lastname: Li
authors.forename: Chang-hong
authors.initials: CH
authors.lastname: Chen
authors.forename: Xiao-ci
authors.initials: XC
authors.lastname: Gao
mesh_terms: D004151:Dipeptides / Q000627:therapeutic use*; D005260:Female; D006501:Hepatic Encephalopathy / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007262:Infusions, Intravenous; D008103:Liver Cirrhosis / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
chemical_list: D004151:Dipeptides; C002939:ornithylaspartate