Getting downstream without a Raft.
The role of plasma-membrane microdomains in the organization of signaling proteins has been a controversial topic in T cell signaling. In this issue of Cell, use of single-molecule fluorescence suggests that protein-protein interactions, not detergent insolubility, regulate the assembly of signaling complexes in the plasma membrane.
Lin
Joseph
J
Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid, Box 8118, Saint Louis, Missouri 63110, USA.
Shaw
Andrey S
AS
D015415:Biomarkers; D049452:Green Fluorescent Proteins / Q000737:chemistry*; D006801:Humans; D019169:Jurkat Cells; D021962:Membrane Microdomains / Q000737:chemistry* / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013050:Spectrometry, Fluorescence / Q000379:methods
D015415:Biomarkers; D049452:Green Fluorescent Proteins