title: C77G mutation in protein tyrosine phosphatase CD45 gene and autoimmune hepatitis.
abstract: Autoimmune hepatitis (AIH) is a rare frequent, multiplex disorder with undefined etiology. Susceptibility to autoimmune hepatitis results from complex interactions between genetic and environmental factors. In this study, we investigated the involvement of C77G mutation in CD45 gene in patients with autoimmune hepatitis among Iranian population by genotyping this mutation in 70 patients and 140 healthy individuals.
  
  
  METHODS
  : After amplifying exon 4 by Polymerase chain reaction, we genotyped this mutation with MspI restriction endonuclease among the studied population.
  
  
  RESULTS
  : None of the cases with AIH was hetero or homozygote for C77G mutation. Controls had normal genotype except one of them who was heterozygote for C77G mutation.
  
  
  CONCLUSIONS
  : Our results do not confirm the genetic link between C77G mutation and autoimmune hepatitis in Iranian population.
authors.affiliation: Research Center for Gastroenterology and Liver Disease, 7th floor, Taleghani Hospital, Tabnak St., Evin, P.O. Box 19835-178, Tehran, Iran; Khatam University, Tehran, Iran.
authors.forename: Fatemehsadat
authors.initials: F
authors.lastname: Esteghamat
authors.forename: Babak
authors.initials: B
authors.lastname: Noorinayer
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Sanati
authors.forename: Azita
authors.initials: A
authors.lastname: Hekmatdoost
authors.forename: Maryam
authors.initials: M
authors.lastname: Zafarghandi
authors.forename: Hamid Mohaghegh
authors.initials: HM
authors.lastname: Shalmani
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Agah
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Zali