Alzheimer's lymphocytes are resistant to ultraviolet B-induced apoptosis.
In the present pilot investigation, the susceptibility of T-lymphocytes from Alzheimer's disease (AD) subjects (n=22) and aged-matched, non-demented controls (CNT) (n=12) was examined with ultraviolet (UV) B light-induced apoptosis in vitro. The basal apoptotic ratios were similar in both groups. However, the AD lymphocytes displayed significantly (p<0.0001) lower apoptotic levels than those of the CNT lymphocytes at all of the applied UVB exposure doses (100, 200 and 300 mJ/cm(2)). These observations indicate that AD lymphocytes are more resistant than CNT lymphocytes to UVB irradiation.
Zana
Marianna
M
Department of Psychiatry, Albert Szent-Györgyi Center for Medical and Pharmaceutical Sciences, University of Szeged, 6 Semmelweis Street, Szeged H-6725, Hungary. mzana@freemail.hu
Juhász
Anna
A
Rimanóczy
Agnes
A
Bjelik
Annamária
A
Baltás
Eszter
E
Ocsovszki
Imre
I
Boda
Krisztina
K
Penke
Botond
B
Dobozy
Attila
A
Kemény
Lajos
L
Janka
Zoltán
Z
Kálmán
János
J
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology*; D000704:Analysis of Variance; D017209:Apoptosis / Q000528:radiation effects*; D016022:Case-Control Studies; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D014466:Ultraviolet Rays / Q000009:adverse effects*