title: Omission of serial arterial blood sampling in neuroreceptor imaging with independent component analysis.
abstract: We have previously proposed a statistical method for extracting a plasma time-activity curve (pTAC) from dynamic PET images, named EPICA, for kinetic analysis of cerebral glucose metabolism. We assumed that the dynamic PET images consist of a blood-related component and a tissue-related component which are spatially independent in a statistical sense. The aim of this study is to investigate the utility of EPICA in imaging total distribution volume (DVt) and binding potential (BP) with Logan plots in a neuroreceptor mapping study. We applied EPICA to dynamic [(11)C]MPDX PET images in 25 subjects, including healthy subjects and patients with brain diseases, and validated the estimated pTACs. [11C]MPDX is a newly developed radiopharmaceutical for mapping cerebral adenosine A1 receptors. EPICA successfully extracted pTAC for all 25 subjects. Parametric images of DVts were estimated by applying Logan plots with the EPICA-estimated pTAC and then used to define a reference region. The BPs estimated using EPICA were evaluated in 18 subjects by ROI-based comparison with those obtained using the nonlinear least squares method (NLSM). The calculated BPs were identical to the estimates using NLSM in each subject. We conclude that EPICA is a promising technique that generates parametric images of DVt and BP in neuroreceptor mapping without requiring arterial blood sampling.
authors.affiliation: Department of Information Processing, Graduate School of Information Science, Nara Institute of Science and Technology, Nara, Japan.
authors.forename: Mika
authors.initials: M
authors.lastname: Naganawa
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kimura
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nariai
authors.forename: Kenji
authors.initials: K
authors.lastname: Ishii
authors.forename: Keiichi
authors.initials: K
authors.lastname: Oda
authors.forename: Yoshitsugu
authors.initials: Y
authors.lastname: Manabe
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Chihara
authors.forename: Kiichi
authors.initials: K
authors.lastname: Ishiwata
mesh_terms: D000465:Algorithms; D001794:Blood Pressure / Q000502:physiology; D001800:Blood Specimen Collection; D001810:Blood Volume / Q000502:physiology; D001921:Brain / Q000033:anatomy & histology*; D001931:Brain Mapping; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D016018:Least-Squares Analysis; D017711:Nonlinear Dynamics; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D043682:Receptor, Adenosine A1 / Q000187:drug effects; D011984:Sensory Receptor Cells / Q000502:physiology*; D014970:Xanthines / Q000493:pharmacokinetics
chemical_list: C451639:1-methyl-8-dicyclopropylmethyl-1-methyl-3-propylxanthine; D019275:Radiopharmaceuticals; D043682:Receptor, Adenosine A1; D014970:Xanthines