Inhibin A and activin A may be used to predict pregnancy outcome in women with recurrent miscarriage.
OBJECTIVE
To look at the role of inhibin and activin in predicting pregnancy outcome in patients with history of recurrent miscarriage.


METHODS
Observational clinical study.


METHODS
Recurrent miscarriage clinic of a tertiary care teaching hospital.


METHODS
Patients with history of recurrent miscarriage.


METHODS
Serial serum inhibin A and activin A concentrations were measured in weeks 5 though 8 of pregnancy.


METHODS
Serum concentrations of inhibin A and activin A levels.


RESULTS
Mean inhibin A concentration at 5 to 6 weeks for women who miscarried and those who had live births was 33 and 51 pg/mL, respectively; activin A at same gestation for the two groups was 534 and 643 pg/mL, respectively. After 2 weeks, mean inhibin A concentration for women who miscarried and those who had live births was 66 and 145 pg/mL, respectively, and activin A was 747 and 1,123 pg/mL, respectively.


CONCLUSIONS
It is possible that inhibin A and activin A may be used as markers to predict pregnancies that are likely to miscarry.
Prakash
Alka
A
Academic Unit of Reproductive and Developmental Medicine, University of Sheffield, Jessop Wing, Sheffield, United Kingdom. a.prakash@sheffield.ac.uk
Laird
Susan
S
Tuckerman
Elizabeth
E
Li
Tin C
TC
Ledger
William L
WL
D000026:Abortion, Habitual / Q000097:blood* / Q000453:epidemiology*; D028341:Activins / Q000097:blood*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D028322:Inhibin-beta Subunits / Q000097:blood*; D007265:Inhibins / Q000097:blood*; D050498:Live Birth / Q000453:epidemiology*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D018709:Statistics, Nonparametric
D015415:Biomarkers; C422405:activin A; C422362:inhibin A; D028341:Activins; D007265:Inhibins; D028322:Inhibin-beta Subunits