Quantitative analysis of bucillamine and its pharmaceutical formulation using FT-IR spectroscopy.
A Fourier transform infrared (FT-IR) spectrometric method was developed for the rapid, direct measurement of bucillamine. Conventional KBr-spectra and DRIFTS spectra were compared for best determination of active substance in its tablet formulation. Two chemometric approaches, partial least squares (PLS) and principal component regression (PCR+) methods were used in data processing. Similar results were obtained with both chemometric methods.
Bunaciu
Andrei A
AA
ROMSPECTRA IMPEX SRL, Analytical Research Department, 25 Street Maguricea, PO Box 52-3, Bucharest, Romania.
Aboul-Enein
Hassan Y
HY
Fleschin
Serban
S
D003545:Cysteine / Q000031:analogs & derivatives* / Q000032:analysis; D016018:Least-Squares Analysis; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D025341:Principal Component Analysis; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013607:Tablets / Q000737:chemistry
D004364:Pharmaceutical Preparations; D013607:Tablets; D003545:Cysteine; C026535:bucillamine