title: A novel simian immunodeficiency virus from black mangabey (Lophocebus aterrimus) in the Democratic Republic of Congo.
abstract: In order to understand primate lentivirus evolution, characterization of additional simian immunodeficiency virus (SIV) strains is essential. Here, an SIV from a black mangabey (Lophocebus aterrimus) originating from the Democratic Republic of Congo was analysed phylogenetically. The monkey had cross-reactive antibodies against human immunodeficiency virus type 1 (HIV-1) and HIV-2. The viral pol region sequence was amplified by nested PCR and sequence analysis confirmed that it was related to known SIV sequences. This is the first report to characterize genetically an SIV from the monkey genus Lophocebus. Phylogenetic analysis of the pol region revealed that this novel SIV, designated SIVbkm, fell into the SIVsyk and SIVgsn virus group, containing viruses isolated from the genus Cercopithecus, and suggests that cross-species transmission has occurred between species of the genera Lophocebus and Cercopithecus.
authors.affiliation: Institute for Virus Research, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
authors.forename: Taichiro
authors.initials: T
authors.lastname: Takemura
authors.affiliation: National Institute of Biomedical Research, Kinshasa, Democratic Republic of Congo.
authors.forename: Michel
authors.initials: M
authors.lastname: Ekwalanga
authors.affiliation: Cite Louis Pasteur-Laboratoire National de Sante Publique, Brazzaville 120, Republic of Congo.
authors.forename: Blaise
authors.initials: B
authors.lastname: Bikandou
authors.affiliation: Institute for Virus Research, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Ido
authors.affiliation: Biological Information Research Center, National Institute of Advanced Industrial Science and Technology, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Yamaguchi-Kabata
authors.affiliation: Institute for Virus Research, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
authors.forename: Sadayuki
authors.initials: S
authors.lastname: Ohkura
authors.affiliation: Institute for Virus Research, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
authors.forename: Hirotada
authors.initials: H
authors.lastname: Harada
authors.affiliation: Department of Viral Infection and International Health, Graduate School of Medical Science, Kanazawa University, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Takehisa
authors.affiliation: Department of Viral Infection and International Health, Graduate School of Medical Science, Kanazawa University, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ichimura
authors.affiliation: Cite Louis Pasteur-Laboratoire National de Sante Publique, Brazzaville 120, Republic of Congo.
authors.forename: Henri-Joseph
authors.initials: HJ
authors.lastname: Parra
authors.affiliation: Kinshasa Zoo, Kinshasa, Democratic Republic of Congo.
authors.forename: Monique
authors.initials: M
authors.lastname: Nende
authors.affiliation: Kinshasa Zoo, Kinshasa, Democratic Republic of Congo.
authors.forename: Eric
authors.initials: E
authors.lastname: Mubwo
authors.affiliation: Kinshasa Zoo, Kinshasa, Democratic Republic of Congo.
authors.forename: Midingi
authors.initials: M
authors.lastname: Sepole
authors.affiliation: Institute for Virus Research, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Hayami
authors.affiliation: Institute for Virus Research, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Miura
mesh_terms: D000818:Animals; D016664:Cercocebus / Q000821:virology*; D002521:Cercopithecus / Q000821:virology; D015023:Democratic Republic of the Congo; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D016097:Simian Acquired Immunodeficiency Syndrome / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification