title: Compatibility testing problems associated with bovine thrombin-treated plasma.
abstract: Plasma converted to serum by the addition of bovine thrombin prior to compatibility testing agglutinated all donor red cells. This finding prompted an investigation of bovine thrombin- associated incompatibility that showed that (1) thrombin derived from bovine plasma contains IgG antibodies directed against all human red cells, and (2) excess (> 50 units/mL) bovine thrombin used for conversion of plasma to serum may cause hemagglutination and erroneous serologic test results because of the presence of heteroagglutinins.
authors.affiliation: Blood Bank, The Johns Hopkins Hospital, Carnegie Building, Room 667, 600 N. Wolfe Street, Baltimore, MD 21287-6667, USA.
authors.forename: R S
authors.initials: RS
authors.lastname: Shirey
authors.forename: A B
authors.initials: AB
authors.lastname: Ciappi
authors.forename: T S
authors.initials: TS
authors.lastname: Kickler
authors.forename: D
authors.initials: D
authors.lastname: Triulzi
authors.forename: P M
authors.initials: PM
authors.lastname: Ness