title: Preoperative fasting: an outdated concept?
abstract: Recent studies have shown that fasting during the preoperative period for elective surgery induces a metabolic state that seems unfavorable for patients. Results from animal studies indicate that rapid depletion of liver glycogen before surgery leads to mobilization of muscle glycogen after surgery, in turn leading to reduced muscle strength. Depletion of liver glycogen also influences the function of the mononuclear phagocytic system (MPS), which is located predominantly in the liver. The MPS is essential in restricting endotoxin, which may translocate from the gut. In addition, surgery per se puts a substantial physical strain on the patient, and fasting may adversely affect the metabolic response to surgery. This paper presents experimental and clinical data that, when combined together, prove that fasting before surgery has adverse consequences for the patient.
authors.affiliation: Department of Surgery, VU Medisch Centrum (Free University Medical Centre), Amsterdam, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Diks
authors.forename: D E C
authors.initials: DE
authors.lastname: van Hoorn
authors.forename: R J
authors.initials: RJ
authors.lastname: Nijveldt
authors.forename: P G
authors.initials: PG
authors.lastname: Boelens
authors.forename: Z
authors.initials: Z
authors.lastname: Hofman
authors.forename: H
authors.initials: H
authors.lastname: Bouritius
authors.forename: Klaske
authors.initials: K
authors.lastname: van Norren
authors.forename: P A M
authors.initials: PA
authors.lastname: van Leeuwen
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005215:Fasting / Q000009:adverse effects* / Q000378:metabolism / Q000502:physiology*; D006003:Glycogen / Q000378:metabolism*; D006801:Humans; D008112:Liver Glycogen / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism; D010587:Phagocytosis; D011300:Preoperative Care / Q000379:methods*
chemical_list: D008112:Liver Glycogen; D006003:Glycogen