title: Stage-I osteochondritis dissecans versus normal variants of ossification in the knee in children.
abstract: BACKGROUND
  Juvenile osteochondritis dissecans (OCD) has a better prognosis than the adult type.
  
  
  OBJECTIVE
  We postulated that the excellent prognosis of juvenile OCD could be explained, at least in part, by the erroneous diagnosis of some developmental variants of ossification as stage-I OCD.
  
  
  METHODS
  Knee MRIs of 38 children, ages 7.5-17.7 years (mean and median age 13 years), were retrospectively reviewed to look for features that might separate normal variants of ossification from stage-I OCD. These included age, gender, site, configuration of the lesion, residual cartilaginous model and presence of edema.
  
  
  RESULTS
  Twenty-three patients (32 condyles) had ossification defects with intact articular cartilage suggestive of stage-I lesions. No stage-II lesions were seen in the posterior femoral condyles. Accessory ossification centers were seen in 11/16 posterior condyles and 3/16 central condyles. Spiculation of existing ossification was seen in 12/16 posterior condylar lesions and 1/16 central condyles. There was a predominance of accessory ossifications and spiculations in the patients with 10% or greater residual cartilaginous model. No edema signal greater than diaphyseal red-marrow signal was seen in the posterior condyles. Clinical follow-up ranged from 0.5 to 38 months, with clinical improvement in 22 out of 23 patients.
  
  
  CONCLUSIONS
  Inclusion of normal variants in the stage-I OCD category might explain, in part, the marked difference in published outcome between the juvenile and adult forms of OCD. Ossification defects in the posterior femoral condyles with intact overlying articular cartilage, accessory ossification centers, spiculation, residual cartilaginous model, and lack of bone-marrow edema are features of developmental variants rather than OCD.
authors.affiliation: C.S. Mott Children's Hospital/F3503, University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0252, USA. kgebarsk@umich.edu
authors.forename: Kathleen
authors.initials: K
authors.lastname: Gebarski
authors.forename: Ramiro J
authors.initials: RJ
authors.lastname: Hernandez
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009999:Ossification, Heterotopic / Q000473:pathology; D010008:Osteochondritis Dissecans / Q000473:pathology*; D010012:Osteogenesis / Q000502:physiology; D011379:Prognosis; D012189:Retrospective Studies