title: Rare trisubstituted sesquiterpenes daucanes from the wild Daucus carota.
abstract: Phytochemical and biological investigation of the roots of the wild Daucus carota ssp. carota afforded three new and four known compounds, including four sesquiterpenes daucane esters (1-3 [new], and 4), one polyacetylene (5), one sesquiterpene coumarin (6), and sitosterol glucoside. The structures of the new compounds were determined by comprehensive NMR studies, including DEPT, COSY, NOESY, HMQC and HMBC analyses. Based on an agar diffusion assay, 1, 2 and 4-6 were screened and found to contain a range of low antibacterial activities against four gram positive (Staphylococcus aureus, Streptomyces scabies, Bacillus subtilus, Bacillus cereus) and two gram negative species (Pseudomonas aeruginosa, Escherichia coli) as well as antifungal against Fusarium oxysporum and Aspergillus niger using cup agar diffusion assay.
authors.affiliation: Department of Chemistry, Faculty of Science, El-Minia University, El-Minia 61519, Egypt. abdellaahmed@yahoo.com
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Ahmed
authors.forename: Mohktar M
authors.initials: MM
authors.lastname: Bishr
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: El-Shanawany
authors.forename: Eman Z
authors.initials: EZ
authors.lastname: Attia
authors.forename: Samir A
authors.initials: SA
authors.lastname: Ross
authors.forename: Paul W
authors.initials: PW
authors.lastname: Paré
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018552:Daucus carota / Q000737:chemistry*; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D012717:Sesquiterpenes