title: Model systems for flavoenzyme activity: site-isolated redox behavior in flavin-functionalized random polystyrene copolymers.
abstract: [reaction: see text] A model system has been developed to study the redox behaviors of flavin derivatives appended onto random polystyrene copolymers through "click" chemistry strategies. The results demonstrate that flavin units attached onto polymers exhibit site-isolated redox behaviors, yielding new materials with electrochemically tunable associations (K(a)(ox) = 450 M(-)(1), K(a)(red) = 18,200 M(-)(1)) to complementary diamidopyridine (DAP) functionality.
authors.affiliation: Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA.
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Carroll
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Jordan
authors.forename: Hao
authors.initials: H
authors.lastname: Xu
authors.forename: Belma
authors.initials: B
authors.lastname: Erdogan
authors.forename: Lisa
authors.initials: L
authors.lastname: Lee
authors.forename: Lily
authors.initials: L
authors.lastname: Cheng
authors.forename: Christopher
authors.initials: C
authors.lastname: Tiernan
authors.forename: Graeme
authors.initials: G
authors.lastname: Cooke
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello
mesh_terms: D004563:Electrochemistry / Q000379:methods*; D005415:Flavins / Q000737:chemistry* / Q000378:metabolism; D007700:Kinetics; D008958:Models, Molecular; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011137:Polystyrenes / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry / Q000378:metabolism; D013816:Thermodynamics
chemical_list: D005415:Flavins; D011137:Polystyrenes; D011725:Pyridines