Advanced paternal age associated with an elevated risk for schizophrenia in offspring in a Japanese population.
OBJECTIVE
Advanced paternal age at birth as a risk for schizophrenia in the adult offspring has been reported in previous studies exclusively conducted in Western countries and Israel. The question has arisen whether this finding could be replicated in countries with socially and culturally different attitudes toward marriage, including factors such as age at marriage. To address this question, we conducted a case-control study of a Japanese population.


METHODS
The subjects were representative inpatients with a DSM-IV diagnosis of schizophrenia. Unrelated healthy volunteers were recruited as control subjects. This study was conducted as one of a series of the projects by use of "The Mother and Child Health Handbooks (MCHHs)," from which information on parental characteristics around the time of birth, including parental ages at birth, had been extracted and recorded on computer.


RESULTS
Ninety-nine subjects with schizophrenia and 381 healthy control subjects enrolled for the study. Advanced paternal, but not maternal, age was associated with an elevated risk for schizophrenia. Reproducibility of the association across different cultures is suggestive of a causal link.
Tsuchiya
Kenji J
KJ
Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Takagai
Shu
S
Kawai
Masayoshi
M
Matsumoto
Hideo
H
Nakamura
Kazuhiko
K
Minabe
Yoshio
Y
Mori
Norio
N
Takei
Nori
N
D000328:Adult; D032721:Adult Children / Q000523:psychology*; D000367:Age Factors; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008423:Maternal Age; D010331:Paternal Age; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D012565:Schizophrenic Psychology