A benzoisofuranone derivative and carbazole alkaloids from Murraya koenigii and their antimicrobial activity.
A benzoisofuranone derivative, 3xi-(1xi-hydroxyethyl)-7-hydroxy-1-isobenzofuranone, and a dimeric carbazole alkaloid, 3,3'-[oxybis(methylene)]bis(9-methoxy-9H-carbazole), along with six known carbazole alkaloids and three known steroids were isolated from the stem bark of Murraya koenigii. The structures of these compounds were established unambiguously by UV, IR, MS and a series of 1D and 2D NMR analyses. The minimum inhibitory concentrations (MIC) of these compounds were found to be in the range 3.13-100 microg/ml.
Rahman
M Mukhlesur
MM
Phytochemistry Research Laboratories, Department of Pharmaceutical Sciences, University of Strathclyde, SIBS Building, 27 Taylor Street, Glasgow G4 ONR, Scotland, UK. mukhlesurrah@yahoo.co.uk
Gray
Alexander I
AI
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002227:Carbazoles / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D032101:Murraya / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry
D000470:Alkaloids; D000890:Anti-Infective Agents; D001572:Benzofurans; D002227:Carbazoles; C105430:benzofuran