title: Learning and memory in aging combat veterans with PTSD.
abstract: The California Verbal Learning Test (CVLT) was administered to examine learning and memory performance in aging combat veterans with (n = 30) and without PTSD (n = 20), and veterans unexposed to combat (n = 15). Combat veterans with PTSD (PTSD+) showed many impairments compared to non-exposed veterans, but only long-delay free recall consistently discriminated the PTSD+ group from combat-exposed subjects without PTSD (PTSD-), when data were corrected for subscale scores on the WAIS (Vocabulary, Block Design). Alterations in total learning were associated with PTSD when controlling for substance abuse and depression. Two contrast measures, proactive interference and recognition hits, distinguished combat from noncombat veterans, and may be related to trauma exposure. Impairments in total learning are similar to what has been observed in Holocaust survivors. However, increased severity of rapid forgetting may be a specific alteration in older combat veterans, likely reflecting aspects of both combat exposure and aging.
authors.affiliation: Traumatic Stress Studies Program, Psychiatry Department, Mount Sinai School of MedicineNew York, NY, USA. Rachel.Yehuda@med.va.gov
authors.forename: Rachel
authors.initials: R
authors.lastname: Yehuda
authors.forename: Julia A
authors.initials: JA
authors.lastname: Golier
authors.forename: Lisa
authors.initials: L
authors.lastname: Tischler
authors.forename: Karina
authors.initials: K
authors.lastname: Stavitsky
authors.forename: Philip D
authors.initials: PD
authors.lastname: Harvey
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D001288:Attention / Q000502:physiology; D003710:Demography; D006801:Humans; D007807:Language Tests / Q000706:statistics & numerical data; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D013313:Stress Disorders, Post-Traumatic / Q000503:physiopathology*; D019966:Substance-Related Disorders / Q000503:physiopathology; D014706:Verbal Learning / Q000502:physiology*; D014728:Veterans