Demonstration of a high level of parasite population homology by quantification of Plasmodium falciparum alleles in matched peripheral, placental, and umbilical cord blood samples.
Plasmodium falciparum msp-1 and msp-2 genes were quantified by fragment analysis in matched placental, peripheral, and cord blood samples. In the three compartments, the multiplicity of infection values were similar, and parasite populations only partially overlapped, as reported. However, identical alleles represented 80 to 95% of the overall parasite populations of each compartment, demonstrating much more homogenous parasite populations than previously thought.
Jafari-Guemouri
Sayeh
S
Faculté de Phamacie, UR 010, Mother and child Health in the Tropics, Institut de Recherche pour le Développement, 75006 Paris, France.
Ndam
Nicaise Tuikue
NT
Bertin
Gwladys
G
Renart
Emily
E
Sow
Sokhna
S
Le Hesran
Jean-Yves
JY
Deloron
Philippe
P
D000483:Alleles; D000818:Animals; D000953:Antigens, Protozoan / Q000235:genetics; D001769:Blood / Q000469:parasitology*; D005260:Female; D005312:Fetal Blood / Q000469:parasitology*; D006801:Humans; D007231:Infant, Newborn; D016778:Malaria, Falciparum / Q000469:parasitology*; D020066:Merozoite Surface Protein 1 / Q000235:genetics; D010920:Placenta / Q000469:parasitology*; D010963:Plasmodium falciparum / Q000235:genetics* / Q000302:isolation & purification; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000469:parasitology; D015800:Protozoan Proteins / Q000235:genetics
D000953:Antigens, Protozoan; D020066:Merozoite Surface Protein 1; D015800:Protozoan Proteins; C065974:merozoite surface protein 2, Plasmodium