title: [Effect of triptolide on urinary monocyte chemottractant protein-1 in patients with diabetic nephropathy].
abstract: OBJECTIVE
  To observe the change of urinary monocyte chemottractant protein-1 (MCP-1) in patients with diabetic nephropathy (DN), and to explore the therapeutic effect and mechanism of triptolide (TL) in treating DN.
  
  
  METHODS
  Thirty-five patients in the treated group were treated with TL plus benazepril and thirty two patients in the control group were treated with benazepril alone for six months. The change of urinary MCP-1 was measured before and after treatment.
  
  
  RESULTS
  Level of urinary MCP-1 in DN patients was significantly higher than that in healthy subjects (P < 0.01), but it could be significantly decreased after TL treatment, showing significant difference as compared with that in the control group (P < 0.05).
  
  
  CONCLUSIONS
  Determination of urinary MCP-1 level is beneficial to know the degree of kidney inflammation in DN patients. TL can inhibit inflammatory reaction to decrease the level of urinary MCP-1, and thus improve the renal function.
authors.affiliation: Linyi Municipal Hospital of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Shandong.
authors.forename: Hai-xiang
authors.initials: HX
authors.lastname: Song
authors.forename: Jing
authors.initials: J
authors.lastname: Gong
authors.forename: Wen
authors.initials: W
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D018932:Chemokine CCL2 / Q000652:urine*; D003928:Diabetic Nephropathies / Q000188:drug therapy* / Q000652:urine; D004224:Diterpenes / Q000627:therapeutic use*; D004852:Epoxy Compounds; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010616:Phenanthrenes / Q000627:therapeutic use*; D008517:Phytotherapy; D011446:Prospective Studies
chemical_list: D018932:Chemokine CCL2; D004224:Diterpenes; D004852:Epoxy Compounds; D007166:Immunosuppressive Agents; D010616:Phenanthrenes; C001899:triptolide