title: [A clinicopathological study of 96 cases of lymphoblastic lymphoma].
abstract: OBJECTIVE
  To investigate the clinicopathological and immunohistochemical features of lymphoblastic lymphoma (LBL).
  
  
  METHODS
  A retrospective clinicopathological study of 96 cases LBL was carried out. Immunohistochemical staining was used for the characterization and immunophenotyping.
  
  
  RESULTS
  The patients age ranged from 4 to 72 years, with a median of 16 years, 69 patients were male and 27 female. Seventy-three cases had superficial or multi-lymphoadenopathy and 31 of them had mediastinal masses. Bone marrow was involved in 15 cases. Seventy-three cases were in clinical stages III and IV. The median survival of the followed-up patients was 5.5 (2 approximately 120) months. TdT and CD99 positive reactions were 75.0% and 92.7%, respectively. Of the 96 cases, 78 displayed T-cell marker positivity and 18 B-cell markers. 82.1% of the patients younger than 30 years of age had significantly higher incidences of T-LBL (64 patients), and 93.6% of the patients with mediastinal masses expressed T-cell markers. The poor prognostic factors were T-cell tumors, clinical stages III and IV, Ki-67 PI < 80% and no chemotherapy (P < 0.01).
  
  
  CONCLUSIONS
  In children and young males, mediastinal masses with superficial or multi-lymphoadenopathy favors the diagnosis of LBL, but negative TdT reaction can not exclude this diagnosis. T-LBL is more common than B-LBL. Clinical stages, immunophenotypes and the level of Ki-67 expression were closely related with prognosis of LBL.
authors.affiliation: West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Pan
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Liu
authors.forename: Jin-Fan
authors.initials: JF
authors.lastname: Li
authors.forename: Wen-Yan
authors.initials: WY
authors.lastname: Zhang
authors.forename: Feng-Yuan
authors.initials: FY
authors.lastname: Li
authors.forename: Xiao-Xi
authors.initials: XX
authors.lastname: Lu
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.forename: Gan-di
authors.initials: GD
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018951:Antigens, CD20 / Q000032:analysis; D051925:CD79 Antigens / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D017493:Leukocyte Common Antigens / Q000032:analysis; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism* / Q000473:pathology*; D011379:Prognosis; D016019:Survival Analysis; D055815:Young Adult
chemical_list: D018951:Antigens, CD20; D051925:CD79 Antigens; D019394:Ki-67 Antigen; D017493:Leukocyte Common Antigens