title: Individual differences in childhood neurobehavior disinhibition predict decision to desist substance use during adolescence and substance use disorder in young adulthood: a prospective study.
abstract: Genetic, physiological and psychological investigations have demonstrated that deficient inhibitory regulation amplifies the risk for substance use disorder (SUD). This study extends this line of research by determining the association between childhood neurobehavior disinhibition and decision to desist substance use following prevention intervention during adolescence. The sample consisted of 302 boys who were evaluated at ages 10-12, 12-14, 16, and 19. Results indicated that childhood neurobehavior disinhibition negatively covaried with decision to desist substance use during adolescence. These two variables predicted acceleration of drug consumption frequency during adolescence and DSM-IV diagnosis of SUD by age 19. Decision to desist drug use did not mediate the association between neurobehavior disinhibition and substance use/SUD. The findings indicate that substance abuse prevention would be potentiated by ameliorating childhood neurobehavior disinhibition.
authors.affiliation: Center for Education and Drug Abuse Research, University of Pittsburgh, PA 15261, USA. levent@pitt.edu
authors.forename: Levent
authors.initials: L
authors.lastname: Kirisci
authors.forename: Ralph E
authors.initials: RE
authors.lastname: Tarter
authors.forename: Maureen
authors.initials: M
authors.lastname: Reynolds
authors.forename: Michael
authors.initials: M
authors.lastname: Vanyukov
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior / Q000523:psychology*; D000328:Adult; D000367:Age Factors; D000428:Alcohol Drinking / Q000523:psychology; D002648:Child; D002652:Child Behavior / Q000523:psychology*; D003657:Decision Making; D005220:Fathers / Q000523:psychology; D006801:Humans; D013287:Illicit Drugs; D007206:Individuality; D007266:Inhibition, Psychological; D033182:Intention; D008297:Male; D008960:Models, Psychological; D009042:Motivation; D011446:Prospective Studies; D000297:Psychology, Adolescent; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000517:prevention & control / Q000523:psychology*
chemical_list: D013287:Illicit Drugs