title: Enhanced relaxation of nanoparticle-bound supercoiled DNA in X-ray radiation.
abstract: A therapeutic methodology was developed based on the large X-ray absorption cross-section of gold nanoparticles at high photon energies (>81 keV). Experimental results showed that the amounts of the relaxed circular supercoiled DNA (scDNA) for gold nanoparticle-bound scDNA were more than doubled compared to that for free scDNA under otherwise identical radiation conditions.
authors.affiliation: Chemistry Department, University of California, Davis, 95616, USA.
authors.forename: Erika A
authors.initials: EA
authors.lastname: Foley
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Carter
authors.forename: Fang
authors.initials: F
authors.lastname: Shan
authors.forename: Ting
authors.initials: T
authors.lastname: Guo
mesh_terms: D004278:DNA, Superhelical / Q000737:chemistry*; D053758:Nanoparticles; D014965:X-Rays
chemical_list: D004278:DNA, Superhelical