title: Persistent pulmonary hypertension of newborn due to congenital capillary alveolar dysplasia.
abstract: Congenital alveolar capillary dysplasia is a rare and fatal cause of pulmonary hypertension in neonates. We report on a term baby with severe pulmonary hypertension unresponsive to high-frequency ventilation and nitric oxide. A diagnosis of alveolar capillary dysplasia was established on autopsy. We review the literature regarding pathophysiology, clinical presentations, associated malformations, and treatment trials.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada. amuchou@yahoo.com
authors.forename: Soraisham Amuchou
authors.initials: SA
authors.lastname: Singh
authors.forename: Thowfique
authors.initials: T
authors.lastname: Ibrahim
authors.forename: Deborah Jane
authors.initials: DJ
authors.lastname: Clark
authors.forename: Richard Scott
authors.initials: RS
authors.lastname: Taylor
authors.forename: David Hilles
authors.initials: DH
authors.lastname: George
mesh_terms: D002196:Capillaries / Q000002:abnormalities*; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology*; D007231:Infant, Newborn; D008168:Lung / Q000648:ultrastructure; D011650:Pulmonary Alveoli / Q000098:blood supply*