The D box asserts itself.
New findings (Burton et al., 2005; Kraft et al., 2005) demonstrate the direct recognition of D and KEN boxes, short sequence elements in substrates of the anaphase-promoting complex/cyclosome (APC/C), by APC/C coactivators and indicate a special role for the D box in the assembly of catalytically active APC/C.
Owens
Thomas J
TJ
Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA.
Hoyt
M Andrew
MA
D048868:Adaptor Proteins, Signal Transducing; D020816:Amino Acid Motifs; D064173:Anaphase-Promoting Complex-Cyclosome; D000071183:Autophagy-Related Proteins; D002352:Carrier Proteins / Q000378:metabolism; D064199:Cdc20 Proteins; D018797:Cell Cycle Proteins / Q000378:metabolism; D004926:Escherichia coli; D009154:Mutation; D013379:Substrate Specificity; D043743:Ubiquitin-Protein Ligase Complexes / Q000378:metabolism*
D048868:Adaptor Proteins, Signal Transducing; D000071183:Autophagy-Related Proteins; D002352:Carrier Proteins; D064199:Cdc20 Proteins; D018797:Cell Cycle Proteins; C107792:UBQLN1 protein, human; C577488:CDC20 protein, human; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome