Venous thrombosis in inflammatory bowel disease.
Patients with inflammatory bowel disease (IBD) have a threefold increased risk of venous thrombosis, a major cause of morbidity and mortality. Although the exact mechanism explaining the initiation of thrombosis remains unclear, it is likely to be a multifactorial process. Reported abnormalities include activation of markers of the coagulation cascade, disturbed fibrinolysis and the activation of platelets. The contribution of thrombophilic disorders such as factor V Leiden, prothrombin gene mutations and hyperhomocysteinaemia are discussed, but their role in thrombosis associated with IBD has remained unclear. Recent research has examined elevated CD40, P-selectin levels and tissue factor-bearing microvesicles in venous thrombosis, and the relevance of these observations to IBD is reviewed.
Srirajaskanthan
Rajaventhan
R
Department of Gastroenterology, the Kent and Canterbury Hospital, Canterbury, Kent CT1 3NG, UK.
Winter
Mark
M
Muller
Andrew F
AF
D001778:Blood Coagulation Disorders / Q000150:complications / Q000235:genetics; D003093:Colitis, Ulcerative / Q000150:complications / Q000235:genetics; D003424:Crohn Disease / Q000150:complications / Q000235:genetics; D005165:Factor V / Q000235:genetics; D006710:Homocysteine / Q000097:blood; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications* / Q000235:genetics; D009154:Mutation / Q000235:genetics; D011516:Prothrombin / Q000235:genetics; D012307:Risk Factors; D020246:Venous Thrombosis / Q000209:etiology* / Q000235:genetics
C095381:factor V Leiden; D006710:Homocysteine; D005165:Factor V; D011516:Prothrombin