title: Intermediate mutation frequencies favor evolution of multidrug resistance in Escherichia coli.
abstract: In studying the interplay between mutation frequencies and antibiotic resistance among Escherichia coli natural isolates, we observed that modest modifications of mutation frequency may significantly influence the evolution of antibiotic resistance. The strains having intermediate mutation frequencies have significantly more antibiotic resistances than strains having low and high mutation frequencies.
authors.affiliation: INSERM U571 and Université Paris 5, France.
authors.forename: Erick
authors.initials: E
authors.lastname: Denamur
authors.forename: Olivier
authors.initials: O
authors.lastname: Tenaillon
authors.forename: Catherine
authors.initials: C
authors.lastname: Deschamps
authors.forename: David
authors.initials: D
authors.lastname: Skurnik
authors.forename: Esthel
authors.initials: E
authors.lastname: Ronco
authors.forename: Jean Louis
authors.initials: JL
authors.lastname: Gaillard
authors.forename: Bertrand
authors.initials: B
authors.lastname: Picard
authors.forename: Catherine
authors.initials: C
authors.lastname: Branger
authors.forename: Ivan
authors.initials: I
authors.lastname: Matic
mesh_terms: D000900:Anti-Bacterial Agents / Q000633:toxicity; D018432:Drug Resistance, Multiple / Q000235:genetics*; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D019143:Evolution, Molecular; D006801:Humans; D009154:Mutation / Q000235:genetics*; D014556:Urine / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents