title: Spread of novel expanded-spectrum beta-lactamases in Enterobacteriaceae in a university hospital in the Paris area, France.
abstract: In 2002, 28 non-duplicate enterobacterial isolates producing extended-spectrum beta-lactamases (ESBLs) were collected from infected patients at the Bicêtre Hospital in Paris, France. Escherichia coli was the predominant ESBL-positive enterobacterial species, comprising ten (36%) of the isolates. CTX-M enzymes (CTX-M-3, CTX-M-10, CTX-M-14 and CTX-M-15) were produced by 11 (39%) of the isolates (six E. coli, two Enterobacter cloacae, one Enterobacter aerogenes, one Proteus mirabilis and one Citrobacter freundii). Other ESBLs, such as VEB-1 and PER-1, were also detected, but less frequently.
authors.affiliation: Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, K.-Bicêtre, France.
authors.forename: M-F
authors.initials: MF
authors.lastname: Lartigue
authors.forename: N
authors.initials: N
authors.lastname: Fortineau
authors.forename: P
authors.initials: P
authors.lastname: Nordmann
mesh_terms: D016971:Citrobacter freundii / Q000187:drug effects / Q000201:enzymology / Q000302:isolation & purification; D021902:Enterobacter aerogenes / Q000187:drug effects / Q000201:enzymology / Q000302:isolation & purification; D016972:Enterobacter cloacae / Q000187:drug effects / Q000201:enzymology / Q000302:isolation & purification; D004755:Enterobacteriaceae / Q000187:drug effects / Q000201:enzymology* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000382:microbiology*; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000382:microbiology*; D005602:France; D006785:Hospitals, University; D006801:Humans; D008826:Microbial Sensitivity Tests; D010297:Paris; D011513:Proteus mirabilis / Q000187:drug effects / Q000201:enzymology / Q000302:isolation & purification; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000032:analysis*; D047090:beta-Lactams / Q000494:pharmacology*
chemical_list: D047090:beta-Lactams; D001618:beta-Lactamases