title: Impurity analysis of retinoic acid samples.
abstract: The structure of an impurity contained in samples of all trans-retinoic acid was established by means of NMR and MS spectra, and confirmed by X-ray diffraction analysis. The chemical structure of the impurity 2 was found to be strictly correlated to the synthetic procedure employed for the preparation of the retinoic acid samples. Single crystal analysis allowed us to characterise the molecular conformation and the crystal structure of 2.
authors.affiliation: Dip. Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Univ. Degli Studi del Piemonte Orientale A.Avogadro, Novara, Italy.
authors.forename: Gianna
authors.initials: G
authors.lastname: Allegrone
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Brenna
authors.forename: Giovanni
authors.initials: G
authors.lastname: Fronza
authors.forename: Claudio
authors.initials: C
authors.lastname: Fuganti
authors.forename: Tommaso
authors.initials: T
authors.lastname: Giovenzana
authors.forename: Luciana
authors.initials: L
authors.lastname: Malpezzi
authors.forename: Enrico
authors.initials: E
authors.lastname: Barlocchi
authors.forename: Cesare
authors.initials: C
authors.lastname: Pellegatta
mesh_terms: D018360:Crystallography, X-Ray / Q000379:methods; D004340:Drug Contamination; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014212:Tretinoin / Q000032:analysis* / Q000737:chemistry
chemical_list: D014212:Tretinoin