[Serum S100 protein and radiation-induced brain injury in astrocytoma patients].
OBJECTIVE
To study the value of serum S100 protein in the diagnosis of radiation-induced brain injury in astrocytoma patients.


METHODS
Serum S100 protein levels were detected by enzyme-linked immunosorbent assay in 86 astrocytoma patients in the course of radiotherapy.


RESULTS
The positivity rates of serum S100 protein before, in the middle of and after radiotherapy were 0, 9.3% (8/86) and 19.8% (17/86), respectively, showing significant differences (P<0.05) between these time points for measurement.


CONCLUSIONS
High levels of serum S100 protein are associated with radiation-induced brain injury in astrocytoma patients and may serve as the marker for early diagnosis of the injury.
Song
Wei-shu
WS
Department of Oncology, Second People's Hospital of Guangdong Province, Guangzhou 510317, China.
Guo
Li-bing
LB
Hong
Zhi-yong
ZY
Li
Jun-Jie
JJ
Wu
Jun
J
D000328:Adult; D001254:Astrocytoma / Q000097:blood / Q000532:radiotherapy*; D015415:Biomarkers / Q000097:blood; D001921:Brain / Q000528:radiation effects; D001932:Brain Neoplasms / Q000097:blood / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000097:blood*; D009418:S100 Proteins / Q000097:blood*
D015415:Biomarkers; D009418:S100 Proteins