Thrombotic and bleeding complications in four subpopulations of patients with essential thrombocythemia defined by c-Mpl protein expression and PRV-1 mRNA levels.
C-Mpl and PRV-1 expression was measured in a cohort of 48 patients with essential thrombocythemia (ET). A retrospective analysis was conducted to asses whether the presence of one or both markers correlates with a higher risk of developing thromboembolic complications. In this cohort, PRV-1 overexpression was associated with a significantly increased risk of thrombosis, whereas decreased c-Mpl expression was not. The results of this retrospective analysis must now be corroborated in a large, prospective trial of newly diagnosed patients.
Goerttler
Philipp L
PL
März
Edith
E
Johansson
Peter L
PL
Andreasson
Björn
B
Kutti
Jack
J
Moliterno
Alison R
AR
Marchioli
Roberto
R
Spivak
Jerry L
JL
Pahl
Heike L
HL
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D058851:GPI-Linked Proteins; D006470:Hemorrhage / Q000150:complications / Q000378:metabolism*; D006801:Humans; D007519:Isoantigens / Q000096:biosynthesis*; D008297:Male; D008562:Membrane Glycoproteins / Q000096:biosynthesis*; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000096:biosynthesis*; D018121:Receptors, Cytokine / Q000096:biosynthesis*; D053628:Receptors, Thrombopoietin; D012189:Retrospective Studies; D012306:Risk; D013920:Thrombocythemia, Essential / Q000150:complications* / Q000378:metabolism*; D013927:Thrombosis / Q000150:complications / Q000378:metabolism*
C407242:CD177 protein, human; D058851:GPI-Linked Proteins; D007519:Isoantigens; D008562:Membrane Glycoproteins; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D018121:Receptors, Cytokine; D053628:Receptors, Thrombopoietin; C082218:MPL protein, human