[Aortic valve stenosis: persistence of infective agents or noninfective inflammatory process?].
The probable risk factors leading to aortic valve calcification are not clearly defined. The cross-sectional study of 85 patients with vascular and valvular calcification was performed. Correlations between the immune tests and aortic stenosis severity were investigated. The predictors of aortic valve calcification were probably C-reactive protein and interleukin-6. The predictors of aortic stenosis progression were interleukin-8, antibodies of Chlamydia pneumoniae and cytomegalovirus, and dysregulation of complement's components. Implication of immune reactivity could influence aortic valve calcification.
Andropova
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Polubentseva
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D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D001024:Aortic Valve Stenosis / Q000097:blood / Q000209:etiology* / Q000473:pathology; D002097:C-Reactive Protein / Q000032:analysis; D002114:Calcinosis / Q000097:blood / Q000209:etiology* / Q000473:pathology; D002690:Chlamydia Infections / Q000150:complications*; D016993:Chlamydophila pneumoniae / Q000276:immunology; D003430:Cross-Sectional Studies; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000150:complications; D018450:Disease Progression; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D012307:Risk Factors; D012426:Russia
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D015850:Interleukin-6; D016209:Interleukin-8; D002097:C-Reactive Protein