title: Inflammation-dependent thrombosis.
abstract: Vessel wall endothelial damage initiates a local inflammatory response, which promotes a prothrombotic state driven by tissue factor, adhesion molecules, and pro-inflammatory cytokines. Understanding how natural inflammatory mechanisms promote a procoagulant state, may lead to the development of new pharmacological interventions targeted at thrombosis.
authors.affiliation: Jobst Vascular Research Laboratories, University of Michigan, Ann Arbor, MI 48109-0654, USA. ddmyers@med.umich.edu
authors.forename: Daniel D
authors.initials: DD
authors.lastname: Myers
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Wakefield
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000150:complications*; D018836:Inflammation Mediators / Q000502:physiology*; D013925:Thromboplastin / Q000502:physiology*; D013927:Thrombosis / Q000453:epidemiology* / Q000209:etiology
chemical_list: D015815:Cell Adhesion Molecules; D018836:Inflammation Mediators; D013925:Thromboplastin