title: Synthesis of bioactive PMMA bone cement via modification with methacryloxypropyltri-methoxysilane and calcium acetate.
abstract: Bone cement consisting of polymethylmethacrylate (PMMA) powder and methylmethacrylate (MMA) liquid is clinically used for fixation of implants such as artificial hip joints. However, it does not show bone-bonding ability, i.e., bioactivity. The lack of bioactivity would be one of factors which cause loosening between the cement and the implant. The present authors recently showed the potential of bioactive PMMA-based bone cement through modification with gamma-methacryloxypropyltrimethoxysilane (MPS) and calcium acetate. In this study, the effects of the kinds of PMMA powder on setting time, apatite formation and compressive strength were investigated in a simulated body fluid (Kokubo solution). The cement modified with calcium acetate calcined at 220 degrees C could set within 15 min when the PMMA powder had an average molecular weight of 100,000 or less. The addition of calcium acetate calcined at 120 degrees C in the PMMA powder required a much longer period for setting. The modified cements formed an apatite layer after soaking in the Kokubo solution within 1 day for cement starting from PMMA powder with a molecular weight of 100,000 or less. Compressive strengths of the modified cements were more than 70 MPa for cements starting from 100,000 and 56,000 in molecular weight. After soaking in Kokubo solution for 7 days, the modified cement consisting of PMMA powder of 100,000 in molecular weight showed a smaller decrease in compressive strength than that consisting of 56,000 in molecular weight. These results indicate that bioactive PMMA cement can be produced with appropriate setting time and mechanical strength when PMMA powders with a suitable molecular weight are used. Such a type of design of bioactive PMMA bone cement leads to a novel development of bioactive material for bone substitutes.
authors.affiliation: Nakashima Medical Division, Nakashima Propeller Co., Ltd., 688-1, Jodo-Kitagata, Okayama, 700-8691, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Mori
authors.forename: C
authors.initials: C
authors.lastname: Ohtsuki
authors.forename: T
authors.initials: T
authors.lastname: Miyazaki
authors.forename: A
authors.initials: A
authors.lastname: Sugino
authors.forename: M
authors.initials: M
authors.lastname: Tanihara
authors.forename: K
authors.initials: K
authors.lastname: Kuramoto
authors.forename: A
authors.initials: A
authors.lastname: Osaka
mesh_terms: D000085:Acetates / Q000032:analysis / Q000737:chemistry*; D000268:Adhesiveness; D001031:Apatites / Q000737:chemistry*; D001826:Body Fluids / Q000737:chemistry*; D001843:Bone Cements / Q000737:chemistry*; D018786:Bone Substitutes / Q000032:analysis / Q000737:chemistry*; D017610:Calcium Compounds; D019245:Compressive Strength; D004548:Elasticity; D006244:Hardness; D008422:Materials Testing; D008689:Methacrylates / Q000032:analysis / Q000737:chemistry*; D008970:Molecular Weight; D010316:Particle Size; D019904:Polymethyl Methacrylate / Q000032:analysis / Q000737:chemistry*; D011208:Powders; D012821:Silanes / Q000032:analysis / Q000737:chemistry*; D044366:Transition Temperature
chemical_list: D000085:Acetates; D001031:Apatites; D001843:Bone Cements; D018786:Bone Substitutes; D017610:Calcium Compounds; D008689:Methacrylates; D011208:Powders; D012821:Silanes; C017492:methacryloxypropyltrimethoxysilane; D019904:Polymethyl Methacrylate; C120662:calcium acetate