title: Ovarian response and follicular development for single-dose and multiple-dose protocols for gonadotropin-releasing hormone antagonist administration.
abstract: OBJECTIVE
  To determine the efficiency of a single-dose and a multiple-dose protocol for GnRH antagonist administration.
  
  
  METHODS
  Randomized clinical trial.
  
  
  METHODS
  University hospital, tertiary medical center.
  
  
  METHODS
  Sixty-one patients undergoing controlled ovarian stimulation (COS) and IVF/ICSI.
  
  
  METHODS
  COS with either a multiple-dose (MD) or a single-dose (SD) protocol for GnRH antagonist (cetrorelix) administration, or with a long protocol (LP) for GnRH agonist (buserelin) administration, followed by oocyte retrieval, IVF/ICSI, and embryo transfer.
  
  
  METHODS
  Follicular development and serum levels of E2 and LH.
  
  
  RESULTS
  The SD protocol for cetrorelix was associated with a more reduced level of follicular development, lower levels of serum estradiol on the day of HCG administration, and a more reduced number of zygotes than the LP for buserelin. The pregnancy and implantation rates did not differ significantly for the three study groups.
  
  
  CONCLUSIONS
  The MD and SD GnRH antagonist protocols were effective for preventing LH surge and appear to elicit an equivalent pregnancy rate to that corresponding to a LP GnRH agonist. In terms of follicular development, the SD protocol requires further modification, including flexible scheduling or possibly a small reduction of the dosage of the administered cetrorelix.
authors.affiliation: Department of Obstetrics and Gynecology, College of Medicine and National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.
authors.forename: Tsung-Hsien
authors.initials: TH
authors.lastname: Lee
authors.forename: Ming-Yih
authors.initials: MY
authors.lastname: Wu
authors.forename: Hsin-Fu
authors.initials: HF
authors.lastname: Chen
authors.forename: Mei-Jou
authors.initials: MJ
authors.lastname: Chen
authors.forename: Hong-Nerng
authors.initials: HN
authors.lastname: Ho
authors.forename: Yu-Shih
authors.initials: YS
authors.lastname: Yang
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D004334:Drug Administration Schedule; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods / Q000706:statistics & numerical data; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors*; D006727:Hormone Antagonists / Q000008:administration & dosage*; D006801:Humans; D006080:Ovarian Follicle / Q000187:drug effects* / Q000254:growth & development; D010062:Ovulation Induction / Q000379:methods* / Q000706:statistics & numerical data; D011247:Pregnancy; D018873:Pregnancy Rate
chemical_list: D006727:Hormone Antagonists; D007987:Gonadotropin-Releasing Hormone; C062876:cetrorelix