title: Pregnancy following intracytoplasmic sperm injection and preimplantation genetic diagnosis after the conservative management of endometrial cancer.
abstract: A rare case of a patient with conservatively treated endometrial carcinoma who conceived and delivered a healthy baby after the transfer of embryos with intracytoplasmic sperm injection (ICSI) and preimplantation genetic diagnosis (PGD) is presented. A 41-year-old woman had an office hysteroscopy in the infertility work-up and stage I endometrial adenocarcinoma was diagnosed. After conservative treatment, the patient underwent ICSI and PGD. She achieved pregnancy with two normal embryos. Two gestational sacs were observed but one of them was blighted. The patient subsequently delivered a healthy female infant. Repeated office hysteroscopy and endometrial sampling was performed after delivery. The appearance of the endometrium was normal on hysteroscopy, and the histology report was normal. The principal concern with medical therapy is that the lesion cannot be fully evaluated until the hysterectomy is performed, the nodes palpated, and the uterus is sectioned. The patient was referred to a gynaecological oncologist for definitive surgery.
authors.affiliation: Women's Health Clinic, Infertility and IVF Centre, Cankaya, Ankara, Turkey. ademirol@gurganclinic.com
authors.forename: A
authors.initials: A
authors.lastname: Demirol
authors.forename: M
authors.initials: M
authors.lastname: Bahce
authors.forename: A
authors.initials: A
authors.lastname: Ayhan
authors.forename: T
authors.initials: T
authors.lastname: Gurgan
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D008297:Male; D008535:Megestrol / Q000627:therapeutic use; D011247:Pregnancy; D011256:Pregnancy Outcome; D019836:Preimplantation Diagnosis; D020554:Sperm Injections, Intracytoplasmic
chemical_list: D018931:Antineoplastic Agents, Hormonal; D008535:Megestrol