title: Optimizing PRESS localized citrate detection at 3 Tesla.
abstract: Analytical methods are used to characterize the response of the strongly coupled two-spin system of citrate to point-resolved spectroscopy (PRESS)-based sequences at 3 T. The signal output is analyzed line by line, as well as in the Cartesian product operator basis. Patterns with a periodicity of 80.9 ms are identified. Furthermore, it is shown that at TE = n . 80.9 ms (n in {0,1,2,...}), the spin evolution can be described without direct reference to strong coupling terms. The theoretical results are found to be in good agreement with in vivo experiments. These results can be used to design protocols for prostate MRS and MRSI at 3 T, and give guidelines for optimizing spin-echo-based acquisition schemes for detecting two-spin systems at arbitrary field strengths.
authors.affiliation: Institute for Biomedical Engineering, ETH Zurich and University of Zurich, Zurich, Switzerland.
authors.forename: Andreas H
authors.initials: AH
authors.lastname: Trabesinger
authors.forename: Dieter
authors.initials: D
authors.lastname: Meier
authors.forename: Ulrike
authors.initials: U
authors.lastname: Dydak
authors.forename: Rolf
authors.initials: R
authors.lastname: Lamerichs
authors.forename: Peter
authors.initials: P
authors.lastname: Boesiger
mesh_terms: D000328:Adult; D000465:Algorithms; D015415:Biomarkers / Q000378:metabolism; D019343:Citric Acid / Q000032:analysis* / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000378:metabolism*; D011522:Protons; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D011522:Protons; D019343:Citric Acid