Brachial artery flow-mediated dilation and myocardial perfusion in patients with cardiac syndrome X.
We assessed the relation between systemic endothelial dysfunction abnormalities (brachial artery flow-mediated dilation) and myocardial perfusion abnormalities (single-photon emission computed tomography) in 41 patients who had cardiac syndrome X. Eighteen patients had normal perfusion scans and 18 had transient perfusion defects. Reverse redistribution was found in 5 patients. Patients who had myocardial perfusion defects had significantly lower flow-mediated dilation values (1.8%) than patients who had normal single-photon emission computed tomograms (3.9%, p = 0.012). Preserved systemic endothelial function appears to rule out the occurrence of transient single-photon emission computed tomographic defects in patients who have cardiac syndrome X.
Masci
Pier Giorgio
PG
Cardiovascular Research Unit, Department of Cardiac and Vascular Sciences, St. George's Hospital Medical School, London, United Kingdom.
Laclaustra
Martin
M
Lara
Juan Garcia
JG
Kaski
Juan Carlos
JC
D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology*; D003326:Coronary Circulation / Q000187:drug effects / Q000502:physiology*; D004176:Dipyridamole; D004562:Electrocardiography; D004730:Endothelium, Vascular / Q000503:physiopathology; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D017566:Microvascular Angina / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008875:Middle Aged; D011237:Predictive Value of Tests; D013793:Thallium / Q000008:administration & dosage; D015899:Tomography, Emission-Computed, Single-Photon; D014463:Ultrasonography; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*; D014665:Vasodilator Agents
D014665:Vasodilator Agents; C027549:thallium chloride; D004176:Dipyridamole; D013793:Thallium