title: Mining the posterior cingulate: segregation between memory and pain components.
abstract: We present a general method for automatic meta-analyses in neuroscience and apply it on text data from published functional imaging studies to extract main functions associated with a brain area-the posterior cingulate cortex (PCC). Abstracts from PubMed are downloaded, words extracted and converted to a bag-of-words matrix representation. The combined data are analyzed with hierarchical non-negative matrix factorization. We find that the prominent themes in the PCC corpus are episodic memory retrieval and pain. We further characterize the distribution in PCC of the Talairach coordinates available in some of the articles. This shows a tendency to functional segregation between memory and pain components where memory activations are predominantly in the caudal part and pain in the rostral part of PCC.
authors.affiliation: Department of Neurology, The Neuroscience Centre, Rigshospitalet, Building 9201, Neurobiology Research Unit, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. fn@imm.dtu.dk
authors.forename: Finn Arup
authors.initials: FA
authors.lastname: Nielsen
authors.forename: Daniela
authors.initials: D
authors.lastname: Balslev
authors.forename: Lars Kai
authors.initials: LK
authors.lastname: Hansen
mesh_terms: D000465:Algorithms; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000502:physiology*; D016208:Databases, Factual; D004644:Emotions / Q000502:physiology; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging / Q000502:physiology*; D006801:Humans; D008568:Memory / Q000502:physiology*; D010146:Pain / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000523:psychology*; D011877:Radionuclide Imaging; D013313:Stress Disorders, Post-Traumatic / Q000503:physiopathology