LGR7-truncate is a splice variant of the relaxin receptor LGR7 and is a relaxin antagonist in vitro.
The relaxin receptor (LGR7) and the insulin-like peptide 3 (INSL3) receptor (LGR8) are unique LGR family members in possessing a single, functionally important amino terminal LDL-A module.1 Mouse and rat cDNA was screened for LGR7 and LGR7 splice variant expression. A uterus-specific exon 4 deleted variant was identified and named LGR7-Truncate. Deletion of exon 4 results in a premature stop codon and a transcript that putatively encodes a secreted protein containing LGR7's LDL-A module. Expression of LGR7-Truncate with LGR7 in HEK-293T cells resulted in decreased relaxin-induced signaling of LGR7. LGR7-Truncate is potentially an endogenous regulator of LGR7 signaling.
Scott
D J
DJ
Howard Florey Institute, University of Melbourne, Victoria 3010, Australia.
Tregear
G W
GW
Bathgate
R A D
RA
D017398:Alternative Splicing / Q000235:genetics*; D000818:Animals; D002460:Cell Line; D000242:Cyclic AMP / Q000378:metabolism; D005260:Female; D006801:Humans; D051379:Mice; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D043562:Receptors, G-Protein-Coupled / Q000235:genetics* / Q000378:metabolism*; D018000:Receptors, Peptide / Q000235:genetics* / Q000378:metabolism*; D012065:Relaxin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014599:Uterus / Q000378:metabolism
D012333:RNA, Messenger; C478103:RXFP1 protein, mouse; D043562:Receptors, G-Protein-Coupled; D018000:Receptors, Peptide; C504789:Rxfp1 protein, rat; D012065:Relaxin; D000242:Cyclic AMP