title: Exploiting synthetic chemistry with mesoionic rings: improvements achieved with thioisomünchnones.
abstract: The chemistry of mesoionic rings, especially their use as masked dipoles, has been a fruitful area of research since the late 1950s. With recent advances in the control of regio- and stereochemistry, the dipolar cycloaddition led to widespread application. In this Account, we illustrate our contribution employing thioisomünchnones, a class of mesoionics that has found use in creating a series of heterocyclic systems hitherto inaccessible by conventional 1,3-dipolar cycloaddition. We also provide some rationalizations from computations and comment on future directions.
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Extremadura, E-06071 Badajoz, Spain.
authors.forename: Martín
authors.initials: M
authors.lastname: Avalos
authors.forename: Reyes
authors.initials: R
authors.lastname: Babiano
authors.forename: Pedro
authors.initials: P
authors.lastname: Cintas
authors.forename: José L
authors.initials: JL
authors.lastname: Jiménez
authors.forename: Juan C
authors.initials: JC
authors.lastname: Palacios