Activated protein C for the treatment of fulminant meningococcal septicaemia.
We report two cases of meningococcal septic shock with multiple organ failure treated with prompt administration of activated protein C. This was associated with a rapid clinical improvement and early cessation of organ support. Both patients survived to hospital discharge with no long-term sequelae.
Thomas
G L
GL
Intensive Care Unit, Westmead Hospital, Westmead, New South Wales.
Wigmore
T
T
Clark
P
P
D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008589:Meningococcal Infections / Q000150:complications / Q000188:drug therapy*; D009102:Multiple Organ Failure / Q000209:etiology*; D011486:Protein C / Q000627:therapeutic use*; D012772:Shock, Septic / Q000188:drug therapy* / Q000382:microbiology
D000925:Anticoagulants; D011486:Protein C