title: RGD mounted on an L-proline scaffold.
abstract: The construction of an L-proline scaffold that enforces a defined beta-turn loop for RGD is reported. A key feature was the use of SASRIN (super acid sensitive resin) that allowed solid-phase synthesis of the tetrapeptide. A HATU-induced cyclization of the sequence was successful, followed by a single acid-promoted deprotection of the final product.
authors.affiliation: Department of Chemistry, University of Florida, Gainesville, FL 32611, USA. enholm@chem.ufl.edu
authors.forename: Eric
authors.initials: E
authors.lastname: Enholm
authors.forename: Ashwin
authors.initials: A
authors.lastname: Bharadwaj
mesh_terms: D003500:Cyclization; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D011392:Proline / Q000737:chemistry*
chemical_list: D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid; D011392:Proline