Homo- and heteromeric assembly of TRP channel subunits.
Mammalian homologues of the Drosophila melanogaster transient receptor potential (TRP) channels are the second largest cation channel family within the superfamily of hexahelical cation channels. Most mammalian TRP channels function as homooligomers and mediate mono- or divalent cation entry upon activation by a variety of stimuli. Because native TRP channels may be multimeric proteins of possibly complex composition, it is difficult to compare cation conductances in native tissues to those of clearly defined homomeric TRP channel complexes in living cells. Therefore, the possibility of heteromeric TRP channel assembly has been investigated in recent years by several groups. As a major conclusion of these studies, most heteromeric TRP channel complexes appear to consist of subunit combinations only within relatively narrow confines of phylogenetic subfamilies. Although the general capability of heteromer formation between closely related TRP channel subunits is now clearly established, we are only beginning to understand whether these heteromeric complexes are of physiological significance. This review summarizes the current knowledge on the promiscuity and specificity of the assembly of channel complexes composed of TRPC-, TRPV- and TRPM-subunits of mammalian TRP channels.
Schaefer
Michael
M
Institut für Pharmakologie, Charité, Universitätsmedizin Berlin, Campus Benjamin Franklin, Thielallee 67-73, 14195 Berlin, Germany. m.schaefer@charite.de
D000818:Animals; D004331:Drosophila melanogaster; D031541:Fluorescence Resonance Energy Transfer; D006801:Humans; D010802:Phylogeny; D020836:Protein Structure, Quaternary; D050052:TRPC Cation Channels / Q000737:chemistry; D050053:TRPM Cation Channels / Q000737:chemistry; D050916:TRPV Cation Channels / Q000737:chemistry; D050051:Transient Receptor Potential Channels / Q000737:chemistry* / Q000378:metabolism*
D050052:TRPC Cation Channels; D050053:TRPM Cation Channels; D050916:TRPV Cation Channels; D050051:Transient Receptor Potential Channels