Developmental impact of leukemic fusion genes on stem cell fate.
Stem and progenitor cells present attractive targets for transformation by leukemia-associated fusion genes generated by chromosomal translocation. The mechanism by which these fusion genes corrupt the transcriptional programs of these cellular compartments remains largely unknown. We have sought to gain insight into these issues through expressing TEL-AML1 and TEL-TRKC fusion genes in murine stem cells and recording effects on cell behavior in a transplant setting.
Enver
Tariq
T
Molecular Haematology Unit, The Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK. tenver@gwmail.jr2.ox.ac.uk
Tsuzuki
Shinobu
S
Brown
John
J
Hong
Dengli
D
Gupta
Rajeev
R
Ford
Tony
T
Egucchi
Minenori-Ishimae
MI
Egucchi
Mariko
M
Greaves
Mel
M
D000818:Animals; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D007938:Leukemia / Q000209:etiology / Q000235:genetics / Q000473:pathology; D051379:Mice; D008954:Models, Biological; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D033581:Stem Cell Transplantation; D014178:Translocation, Genetic
D015514:Oncogene Proteins, Fusion