What has senescence got to do with cancer?
Cancer therapeutics are primarily thought to work by inducing apoptosis in tumor cells. However, various tumor suppressors and oncogenes have been shown to regulate senescence in normal cells, and senescence bypass appears to be an important step in the development of cancer. Cellular senescence limits the replicative capacity of cells, thus preventing the proliferation of cells that are at different stages of malignancy. A recent body of evidence suggests that induction of senescence can be exploited as a basis for cancer therapy.
Dimri
Goberdhan P
GP
Division of Cancer Biology, Department of Medicine, ENH Research Institute, and Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 1001 University Place, Evanston, IL 60201, USA. gdimri@enh.org
D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016922:Cellular Senescence / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D009363:Neoplasm Proteins / Q000502:physiology; D009369:Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D009687:Nuclear Proteins / Q000502:physiology; D000071156:Promyelocytic Leukemia Protein; D016160:Retinoblastoma Protein / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D016615:Telomere / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology; D025803:Tumor Suppressor Protein p14ARF / Q000502:physiology; D016159:Tumor Suppressor Protein p53 / Q000502:physiology; D025521:Tumor Suppressor Proteins / Q000502:physiology
D000970:Antineoplastic Agents; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D000071156:Promyelocytic Leukemia Protein; D016160:Retinoblastoma Protein; D014157:Transcription Factors; D025803:Tumor Suppressor Protein p14ARF; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins; C070576:PML protein, human