title: Intron position conservation across eukaryotic lineages in tubulin genes.
abstract: A compilation of intron positions obtained from a large number of eukaryotic genomes across orthologous tubulins is explored for molecular evolution. Comparison of intron positions for 41 alpha, 80 beta, and 30 gamma tubulin genomic sequences indicates that the putative ancestral tubulin gene contained at least 19, 33, and 52 intron positions distributed at different sites in the coding regions for alpha, beta, and gamma tubulins, respectively. Many intron positions are old and are conserved across different eukaryotic lineages and intron distribution patterns are consistent with 'introns-early' hypothesis.
authors.affiliation: NCSV, MAE, Nanyang Technological University, 639798, Singapore.
authors.forename: Bagavathi S
authors.initials: BS
authors.lastname: Perumal
authors.forename: Kishore R
authors.initials: KR
authors.lastname: Sakharkar
authors.forename: Vincent Tak Kwong
authors.initials: VT
authors.lastname: Chow
authors.forename: Kangueane
authors.initials: K
authors.lastname: Pandjassarame
authors.forename: Meena Kishore
authors.initials: MK
authors.lastname: Sakharkar
mesh_terms: D000818:Animals; D017124:Conserved Sequence; D005057:Eukaryotic Cells / Q000502:physiology*; D019143:Evolution, Molecular; D007438:Introns / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny; D012689:Sequence Homology, Nucleic Acid; D014404:Tubulin / Q000235:genetics*
chemical_list: D014404:Tubulin