Androgen metabolic genes in prostate cancer predisposition and progression.
Significant evidence implicates androgens in prostate cancer etiology. We review recent data with regard to the association between several allelic variants of specific androgen-metabolic genes and the predisposition to prostate cancer. We also review the emerging evidence regarding the role of genetic variants of these genes as well as the androgen receptor in prostate cancer progression. Based on the prostate cancer paradigm, we propose that a multidisciplinary attack on the problem--involving biochemistry, genetics, pharmacogenetics, endocrinology and molecular epidemiology--may be important for the understanding and successful treatment of complex (in terms of etiology) human diseases.
Makridakis
Nick M
NM
Department of Biochemistry and Molecular Biology, Institute for Genetic Medicine, USC Keck School of Medicine, 2250 Alcazar Street, Los Angeles, CA 90089-9075, USA.
Buchanan
Grant
G
Tilley
Wayne
W
Reichardt
Juergen K V
JK
D000728:Androgens / Q000235:genetics*; D018450:Disease Progression; D020022:Genetic Predisposition to Disease; D006801:Humans; D006913:Hydroxysteroid Dehydrogenases / Q000235:genetics; D008297:Male; D006899:Mixed Function Oxygenases / Q000235:genetics; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology; D011944:Receptors, Androgen / Q000235:genetics; D013254:Steroid 17-alpha-Hydroxylase / Q000235:genetics
D000728:Androgens; D011944:Receptors, Androgen; D006899:Mixed Function Oxygenases; D006913:Hydroxysteroid Dehydrogenases; D013254:Steroid 17-alpha-Hydroxylase