The other transmissible spongiform encephalopathies.
Murine leukemia viruses may produce encephalopathies that have the same characteristics as those induced by infectious proteins or prions: neuronal loss, astrocytosis, and absence of inflammatory response. The pathogenic mechanism is still poorly understood but it seems that it involves the envelope proteins (Env), which may be misprocessed in the cell, giving rise to pathogenic isoforms that trigger oxidative damage. Env may also affect the cytokine pattern in the central nervous system and thus, induce encephalopathy.
Gomez-Lucia
Esperanza
E
Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain. duato@vet.ucm.es
D000818:Animals; D007562:Creutzfeldt-Jakob Syndrome / Q000635:transmission* / Q000821:virology; D016207:Cytokines / Q000378:metabolism; D015686:Gene Products, env / Q000235:genetics / Q000378:metabolism; D006801:Humans; D009052:Leukemia Virus, Murine / Q000235:genetics / Q000472:pathogenicity*; D008954:Models, Biological; D017096:Prion Diseases / Q000175:diagnosis / Q000635:transmission*; D012307:Risk Factors; D014777:Virus Diseases / Q000473:pathology / Q000635:transmission
D016207:Cytokines; D015686:Gene Products, env