Novel PdII-mediated cascade carboxylative annulation to construct benzo[b]furan-3-carboxylic acids.
[reaction: see text] Benzo[b]furan-3-carboxylic acid (2) was generated from 1 by forming three new bonds in one step via a Pd(II)-mediated cascade carboxylative annulation. The proposed mechanism was supported by the observation of an unusual acetylation of 1 as a side reaction together with an (18)O-labeling study.
Liao
Yun
Y
VivoQuest, Inc., 711 Executive Blvd, Valley Cottage, New York 10989, USA. y.liao@vivoquest.com
Smith
Jennifer
J
Fathi
Reza
R
Yang
Zhen
Z