title: Churg-Strauss syndrome associated with hypersensitivity to acetaminophen.
abstract: Acetaminophen is a widely used antipyretic drug. We describe a 64-year-old Japanese woman who developed typical Churg-Strauss syndrome after frequent use of acetaminophen. Following the ingestion of acetaminophen, she exhibited various allergic reactions such as asthmatic attacks, pyrexia and petechiae on legs. In the lymphocyte transformation test, a positive reaction to acetaminophen was detected. A muscle biopsy revealed massive extravascular eosinophil infiltration and a necrotizing vasculitis. Hypersensitivity to acetaminophen may be implicated in the development of Churg-Strauss syndrome in this case.
authors.affiliation: Division of Integrated Medicine I, Omiya Medical Center, Jichi Medical School, Saitama, Japan.
authors.forename: Aki
authors.initials: A
authors.lastname: Masuzawa
authors.forename: Masato
authors.initials: M
authors.lastname: Moriguchi
authors.forename: Tokutaro
authors.initials: T
authors.lastname: Tsuda
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Sugawara
authors.forename: Mieko
authors.initials: M
authors.lastname: Otsuka
authors.forename: Shigeki
authors.initials: S
authors.lastname: Yamada
authors.forename: Kaoru
authors.initials: K
authors.lastname: Tabei
authors.forename: Masanobu
authors.initials: M
authors.lastname: Kawakami
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects* / Q000627:therapeutic use; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects* / Q000627:therapeutic use; D001158:Arteries / Q000473:pathology; D001706:Biopsy; D002908:Chronic Disease; D015267:Churg-Strauss Syndrome / Q000139:chemically induced* / Q000473:pathology; D004342:Drug Hypersensitivity; D005260:Female; D005500:Follow-Up Studies; D006261:Headache / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen