DNA break repair: refined rules of an already complicated game.
Of the many types of DNA-damage repair, this review concentrates on the aspects of DNA single- and double-strand break repair. Originally considered to represent separate routes based on distinct enzymatic machineries, it has recently been shown that these pathways converge and are interlinked at a number of points. Poly(ADP-ribose) polymerase-1 (PARP-1) is a central player in this complicated game. We present new data and our view on the mechanisms by which PARP-1 is guided to its respective interaction partners to coordinate or participate in repair or apoptosis.
Vidaković
Melita
M
Molecular Biology Laboratory, Institute for Biological Research, Belgrade, Serbia and Montenegro.
Poznanović
Goran
G
Bode
Juergen
J
D000818:Animals; D017209:Apoptosis; D002467:Cell Nucleus / Q000378:metabolism; D004247:DNA / Q000737:chemistry; D004249:DNA Damage; D011088:DNA Ligases / Q000737:chemistry; D004260:DNA Repair; D005720:Gamma Rays; D006801:Humans; D008954:Models, Biological; D010957:Plasmids / Q000378:metabolism; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases / Q000502:physiology*; D013997:Time Factors
D004247:DNA; C499320:PARP1 protein, human; C483041:PARP2 protein, human; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases; D011088:DNA Ligases