Therapeutic perspectives of adipocytokines.
Various adipocyte-secreted factors have been described which profoundly affect insulin sensitivity and might potentially link obesity, insulin resistance and cardiovascular disease. Among those, adiponectin, visfatin and omentin appear as insulin-sensitising adipocytokines, whereas TNF-alpha, IL-6 and resistin induce insulin resistance. Moreover, leptin is a fat-derived key regulator of appetite and energy expenditure. Due to their profound effect on whole-body glucose and energy metabolism, adipocytokines have attracted interest as potential new therapeutics for diabetes mellitus and obesity. The current knowledge on function, regulation and therapeutic potential of various adipocytokines, as well as their clinical implications, are discussed in this review.
Kralisch
Susan
S
Department of Internal Medicine III, University of Leipzig, Ph.-Rosenthal-Str.27, 04103 Leipzig, Germany.
Klein
Johannes
J
Bluher
Matthias
M
Paschke
Ralf
R
Stumvoll
Michael
M
Fasshauer
Mathias
M
D017667:Adipocytes / Q000378:metabolism*; D000818:Animals; D016207:Cytokines / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism; D036361:Peptide Hormones / Q000378:metabolism / Q000627:therapeutic use; D045162:Thiazolidinediones / Q000378:metabolism / Q000627:therapeutic use*
D016207:Cytokines; D036361:Peptide Hormones; D045162:Thiazolidinediones