title: [Preparation and surface modification of the magnetic fluid as a targeted drug carrier].
abstract: Magnetic fluid containing Fe(3)O(4) as mother nucleus was prepared by chemical coprecipitation and treated with dextran-70 for surface modification. The dextran-70-modified magnetic fluid was reacted with 6-bromohexanoic acid and their chemical stability was studied, with the structure characterized by using laser granulometer, X-ray diffraction, Fourier-transform infrared analysis and transmission electron microscopy. The results showed that the magnetic fluid with surface modification by dextran-70 exhibited high stability in the presence strong alkali or acid. No chemical changes occurred in the magnetic Fe(3)O(4) nucleus surrounded by alkali-treated dextran-70 and the organic chain linked to the surface dextran rendered the reaction to the anti-cancer drug such as mitomycin C possible, suggesting the potential of the preparation as a drug carrier.
authors.affiliation: Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. yxqdoctor@163.com
authors.forename: Xi-qing
authors.initials: XQ
authors.lastname: Yan
authors.forename: Jian-hai
authors.initials: JH
authors.lastname: Chen
authors.forename: Qing-feng
authors.initials: QF
authors.lastname: Jiang
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Na
authors.initials: N
authors.lastname: Xi
authors.forename: Zhi-shen
authors.initials: ZS
authors.lastname: Wu
mesh_terms: D000977:Antiparasitic Agents / Q000008:administration & dosage; D003911:Dextrans / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis*; D016503:Drug Delivery Systems; D004355:Drug Stability; D005290:Ferric Compounds / Q000737:chemistry; D008280:Magnetics; D016685:Mitomycin / Q000008:administration & dosage / Q000737:chemistry; D013499:Surface Properties
chemical_list: D000977:Antiparasitic Agents; D003911:Dextrans; D004337:Drug Carriers; D005290:Ferric Compounds; D016685:Mitomycin