title: Duodenal gangliocytic paraganglioma: a radiological-pathological correlation.
abstract: Duodenal gangliocytic paraganglioma is a rare tumor that characteristically occurs in the second portion of the duodenum and typically presents with gastrointestinal bleeding. Gangliocytic paragangliomas have a characteristic triphasic microscopic appearance with epithelioid cells, spindle cells, and ganglion cells, resulting in a complex histology with features of paraganglioma, carcinoid, and ganglioneuroma. Duodenal gangliocytic paragangliomas have an excellent prognosis after surgical resection but metastatic spread to regional lymph nodes and recurrence may rarely occur. We report a case of duodenal gangliocytic paraganglioma and discuss the radiological and pathological differential diagnosis of this rare entity.
authors.affiliation: Department of Pathology, The Ohio State University Medical Center, Columbus, OH 43210, USA.
authors.forename: Jose Antonio
authors.initials: JA
authors.lastname: Plaza
authors.forename: Kenneth
authors.initials: K
authors.lastname: Vitellas
authors.forename: William L
authors.initials: WL
authors.lastname: Marsh
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002276:Carcinoid Tumor / Q000175:diagnosis; D003937:Diagnosis, Differential; D018572:Disease-Free Survival; D004379:Duodenal Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D005260:Female; D005729:Ganglioneuroma / Q000175:diagnosis; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D018317:Nerve Sheath Neoplasms / Q000175:diagnosis; D010235:Paraganglioma / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D009418:S100 Proteins / Q000378:metabolism; D018235:Smooth Muscle Tumor / Q000175:diagnosis; D017154:Stromal Cells / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D009418:S100 Proteins