title: Prevalence of erythromycin and clindamycin resistance among Streptococcus agalactiae isolates in Germany.
abstract: The antimicrobial susceptibilities of 338 clinical Streptococcus agalactiae isolates from two geographical regions in Germany were determined by agar dilution. All isolates were susceptible to penicillin, cefotaxime and vancomycin. The overall frequencies of erythromycin and clindamycin resistance were 11% and 4.7%, respectively. Determination of resistance phenotypes among the 37 erythromycin-resistant isolates revealed constitutive and inducible MLS(B) resistance in 40.6% and 37.8% of isolates, respectively, and susceptibility to clindamycin in 21.6% of isolates. Only 14.3% of isolates with inducible MLS(B) resistance were identified as clindamycin-resistant by determination of clindamycin MICs. Pulsed-field gel electrophoresis suggested a clonal distribution pattern among the erythromycin-resistant isolates.
authors.affiliation: Hygiene-Institut, Universität Heidelberg, Heidelberg, Germany.
authors.forename: T E
authors.initials: TE
authors.lastname: Schoening
authors.forename: J
authors.initials: J
authors.lastname: Wagner
authors.forename: M
authors.initials: M
authors.lastname: Arvand
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology*; D016172:DNA Fingerprinting; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D004917:Erythromycin / Q000494:pharmacology*; D005260:Female; D005858:Germany; D006801:Humans; D008826:Microbial Sensitivity Tests; D017720:Molecular Epidemiology; D011247:Pregnancy; D013290:Streptococcal Infections / Q000382:microbiology; D013292:Streptococcus agalactiae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D002981:Clindamycin; D004917:Erythromycin