Antineoplastic activity of new lanthanide (cerium, lanthanum and neodymium) complex compounds.
Cerium (III), lanthanum (III) and neodymium (III) complexes with 3,3'-benzylidenebis[4-hydroxycoumarin] were synthesized in view of their application as cytotoxic agents. The complexes were characterized by different physicochemical methods: elemental analysis, mass spectrometry, 1H NMR, 13C NMR and IR spectroscopy. The spectra of the complexes were interpreted on the basis of comparison with the spectrum of the free ligand. The vibrational analysis showed that in the complexes the ligand coordinated to the metal ion through both deprotonated hydroxyl groups; however, participation of the carbonyl groups in the coordination to the metal ion was also suggested. The evaluation of the cytotoxic activity of the novel lanthanide complexes on HL-60 myeloid cells revealed that they are potent cytotoxic agents. The cerium complex was found to exhibit superior activity in comparison to the lanthanum and neodymium coordination compounds, the latter being the least active. Our data give us reason to conclude that the newly synthesized lanthanide complexes should be submitted to further more detailed pharmacological and toxicological evaluation.
Kostova
Irena
I
Department of Chemistry, Faculty of Pharmacy, Medical University, 2 Dunav St., Sofia 1000, Bulgaria. irenakostova@yahoo.com
Kostova
Raina
R
Momekov
Georgi
G
Trendafilova
Natasha
N
Karaivanova
Margarita
M
D015110:4-Hydroxycoumarins / Q000138:chemical synthesis / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002563:Cerium / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D028581:Lanthanoid Series Elements / Q000627:therapeutic use*; D007811:Lanthanum / Q000627:therapeutic use; D009682:Magnetic Resonance Spectroscopy; D009354:Neodymium / Q000627:therapeutic use; D013055:Spectrophotometry, Infrared
D015110:4-Hydroxycoumarins; D000970:Antineoplastic Agents; D028581:Lanthanoid Series Elements; D009354:Neodymium; D002563:Cerium; D007811:Lanthanum