Association of CTLA4 polymorphism with regulatory T cell frequency.
A common single nucleotide polymorphism in CTLA4 has been linked with susceptibility and outcome in autoimmune and infectious diseases, respectively. Here, we show that this polymorphism is associated with the frequency of CD4(+)CD25(+) regulatory T cells in healthy human volunteers. We further show that, on a per cell basis, such regulatory T cells appear to be functionally indistinguishable across CTLA4 genotypes. These data implicate CTLA4 in regulatory T cell development, and provide a mechanism to account for the link between polymorphisms at this locus and the biological outcome of adaptive immune responses to self and to pathogens.
Atabani
Sowsan F
SF
Division of Molecular Immunology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Thio
Chloe L
CL
Divanovic
Senad
S
Trompette
Aurelien
A
Belkaid
Yasmine
Y
Thomas
David L
DL
Karp
Christopher L
CL
D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000235:genetics*; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology* / Q000276:immunology*; D060908:CTLA-4 Antigen; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D016176:T-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology
D015703:Antigens, CD; D000943:Antigens, Differentiation; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human