(1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: a novel class of potent MSK-1-inhibitors.
A novel series of imidazo[4,5-c]pyridines bearing a 1,2,5-oxadiazol-3-ylamine functionality has been developed. These are potent inhibitors of mitogen and stress-activated protein kinase-1.
Bamford
Mark J
MJ
GlaxoSmithKline Pharmaceuticals, Neurology and GI Centre of Excellence for Drug Discovery, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK. Mark_J_Bamford@GSK.com
Alberti
Michael J
MJ
Bailey
Nicholas
N
Davies
Susannah
S
Dean
David K
DK
Gaiba
Alessandra
A
Garland
Stephen
S
Harling
John D
JD
Jung
David K
DK
Panchal
Terence A
TA
Parr
Christopher A
CA
Steadman
Jon G
JG
Takle
Andrew K
AK
Townsend
James T
JT
Wilson
David M
DM
Witherington
Jason
J
D000588:Amines / Q000138:chemical synthesis / Q000145:classification / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000145:classification / Q000494:pharmacology*; D007093:Imidazoles / Q000138:chemical synthesis / Q000145:classification / Q000494:pharmacology*; D015394:Molecular Structure; D010069:Oxadiazoles / Q000138:chemical synthesis / Q000145:classification / Q000494:pharmacology*; D011725:Pyridines / Q000138:chemical synthesis / Q000145:classification / Q000494:pharmacology*; D038744:Ribosomal Protein S6 Kinases, 90-kDa / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D000588:Amines; D004791:Enzyme Inhibitors; D007093:Imidazoles; D010069:Oxadiazoles; D011725:Pyridines; D038744:Ribosomal Protein S6 Kinases, 90-kDa; C116919:mitogen and stress-activated protein kinase 1