Direct injection of (188)Re-microspheres in the treatment of hepatocellular carcinoma: compared with traditional percutaneous ethanol injection: an animal study.
The AIM of this study was to compare the therapeutic efficacies of direct intratumoural injection of (188)Re microspheres (DIRM) and direct intratumoural injection of ethanol (DIE) in rabbits bearing liver tumours.


METHODS
Fifteen rabbits bearing liver tumours were divided into three groups: group 1 received DIE, group 2 received DIRM, and group 3 (control) received saline. Tumour size was measured by liver sonography before injection, as well as 2, 4, 8, and 12 weeks after injection. Survival time was calculated from the day of treatment to three months after treatment by Kaplan-Meier survival analysis.


RESULTS
The mean survival time was 68 +/- 9.8 days for the rabbits in the DIRM group, 55.8 +/- 11.8 days for the DIE group, and 38.8 +/- 6.2 days for the control group.


CONCLUSIONS
The rabbits survived longer in the DIRM group than in the DIE group although there is no statistical significance. We believe the DIRM method has a good potential to be an alternative to DIE for the treatment of liver tumours.
Lin
Y-Ch
YC
Department of Nuclear Medicine, Taichung Veterans General Hospital, 160, Sec. 3, Taichung Harbor Road, Taichung 407, Taiwan. wylin@vghtc.gov.tw
Tsai
S-Ch
SC
Hung
G-U
GU
Lee
J-Ch
JC
Huang
Y-S
YS
Lin
W-Y
WY
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D004195:Disease Models, Animal; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D008863:Microspheres; D011817:Rabbits; D011877:Radionuclide Imaging; D012211:Rhenium / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
D012211:Rhenium