Cyclosporine and sirolimus interaction in a kidney transplant patient.
Cyclosporin A and sirolimus are becoming commonly used in immunosuppressive treatment in organ transplant patients. The drugs are both metabolized by cytochrome P450 3A4 and are substrates of P-glycoprotein. Thus, interaction between these drugs is possible. The case reported here illustrated that clinicians should be aware of this important drug-drug interaction.
Dabrowska-Zamojcin
E
E
Department of Pharmacology, Transplantation and Internal Medicine, Academy of Medicine, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111 Szczecin, Poland.
Pawlik
A
A
Domański
L
L
Rózański
J
J
Droździk
M
M
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D000328:Adult; D001667:Binding, Competitive; D016572:Cyclosporine / Q000493:pharmacokinetics / Q000627:therapeutic use*; D051544:Cytochrome P-450 CYP3A; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000276:immunology*; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D020123:Sirolimus / Q000276:immunology / Q000627:therapeutic use*; D014184:Transplantation, Homologous
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003577:Cytochrome P-450 Enzyme System; C104464:CYP3A protein, human; D051544:Cytochrome P-450 CYP3A; D009173:Mycophenolic Acid; D020123:Sirolimus