Efficacy of benzimidazole carbamate on an intestinal fluke co-infected with nematodes.
The efficacy of a single dose of benzimidazole, drugs commonly used for the treatment of Ascaris and hookworm, was evaluated against one of the tiny-sized intestinal flukes, Haplorchis sp in the endemic area where mixed infections of roundworms and flatworms existed. At day 7 after treatment, albendazole (400 mg) induced 42.5% cure rate, mebendazole (500 mg) a cure rate of 32.4%, on the other hand, praziquantel (40 mg/kg) gave 94.6% cure rate and the placebo at 15.9%. At the single dose, benzimidazole could not completely expelled the haplorchid; but could reduce one third to two fifth of the infection, similar to the drugs efficacy against Trichuris infection.
Waikagul
Jitra
J
Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
Watthanakulpanich
Dorn
D
Muennoo
Chatree
C
Maipanich
Wanna
W
Sa-nguankiat
Surapol
S
Phubampen
Somchit
S
D015766:Albendazole / Q000627:therapeutic use; D000871:Anthelmintics / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D006373:Helminthiasis / Q000188:drug therapy*; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy*; D008463:Mebendazole / Q000627:therapeutic use; D011223:Praziquantel / Q000627:therapeutic use; D013785:Thailand; D016896:Treatment Outcome
D000871:Anthelmintics; D001562:Benzimidazoles; D011223:Praziquantel; D008463:Mebendazole; C031000:benzimidazole; D015766:Albendazole