Medium-sized peptides as built in carriers for biologically active compounds.
A growing number of oligopeptides of natural and/or synthetic origin have been described and considered as targeting structures for delivery bioactive compounds into various cell types. This review will outline the discovery of peptide sequences and the corresponding mid-sized oligopeptides with membrane translocating properties and also summarize de novo designed structures possessing similar features. Conjugates and chimera constructs derived from these sequences with covalently attached bioactive peptide, epitope, oligonucleotide, PNA, drug, reporter molecule will be reviewed. A brief note will refer to the present understanding on the uptake mechanism at the end of each section.
Hudecz
Ferenc
F
Research Group of Peptide Chemistry, Hungarian Academy of Sciences, Eötvös Loránd University, Budapest 112, POB 32, Hungary H-1518. hudecz@szerves,chem.elte.hu
Bánóczi
Zoltán
Z
Csík
Gabriella
G
D000595:Amino Acid Sequence; D051943:Antennapedia Homeodomain Protein / Q000008:administration & dosage; D004247:DNA / Q000008:administration & dosage; D004337:Drug Carriers / Q000138:chemical synthesis / Q000494:pharmacology; D015696:Gene Products, tat / Q000494:pharmacology; D015700:HIV Envelope Protein gp41 / Q000008:administration & dosage; D057927:Hydrophobic and Hydrophilic Interactions; D008081:Liposomes / Q000494:pharmacology; D008969:Molecular Sequence Data; D009479:Neuropeptides / Q000008:administration & dosage; D009842:Oligopeptides / Q000008:administration & dosage / Q000737:chemistry / Q000502:physiology*; D010446:Peptide Fragments / Q000008:administration & dosage; D020135:Peptide Nucleic Acids / Q000008:administration & dosage; D010748:Phosphopeptides / Q000008:administration & dosage; D021382:Protein Sorting Signals / Q000502:physiology; D011993:Recombinant Fusion Proteins / Q000494:pharmacology; D015678:Viral Structural Proteins / Q000008:administration & dosage
D051943:Antennapedia Homeodomain Protein; D004337:Drug Carriers; D015696:Gene Products, tat; D015700:HIV Envelope Protein gp41; C098314:HIV envelope glycoprotein gp41 (593-603); D008081:Liposomes; D009479:Neuropeptides; D009842:Oligopeptides; D010446:Peptide Fragments; D020135:Peptide Nucleic Acids; D010748:Phosphopeptides; D021382:Protein Sorting Signals; D011993:Recombinant Fusion Proteins; D015678:Viral Structural Proteins; C073413:herpes simplex virus type 1 protein VP22; D004247:DNA