Age effects on atrophy rates of entorhinal cortex and hippocampus.
The effects of age, subcortical vascular disease, apolipoprotein E (APOE) epsilon4 allele and hypertension on entorhinal cortex (ERC) and hippocampal atrophy rates were explored in a longitudinal MRI study with 42 cognitively normal (CN) elderly subjects from 58 to 87 years old. The volumes of the ERC, hippocampus, and white matter hyperintensities (WMH) and the presence of lacunes were assessed on MR images. Age was significantly associated with increased atrophy rates of 0.04+/-0.02% per year for ERC and 0.05+/-0.02% per year for hippocampus. Atrophy rates of hippocampus, but not that of ERC increased with presence of lacunes, in addition to age. WMH, APOE epsilon4 and hypertension had no significant effect on atrophy rates. In conclusion, age and presence of lacunes should be taken into consideration in imaging studies of CN subjects and AD patients to predict AD progression and assess the response to treatment trials.
Du
An-Tao
AT
Magnetic Resonance Unit (114M), Department of Veterans Affairs Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA.
Schuff
Norbert
N
Chao
Linda L
LL
Kornak
John
J
Jagust
William J
WJ
Kramer
Joel H
JH
Reed
Bruce R
BR
Miller
Bruce L
BL
Norman
David
D
Chui
Helena C
HC
Weiner
Michael W
MW
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D001284:Atrophy; D001921:Brain / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000473:pathology; D018728:Entorhinal Cortex / Q000254:growth & development* / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000254:growth & development* / Q000473:pathology*; D006801:Humans; D006973:Hypertension / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male
D053327:Apolipoprotein E4; D001057:Apolipoproteins E