title: [Relationships between circulating matrix metalloproteinase-1, -2 and metalloproteinase-1 levels and bone biochemical markers and bone mineral density in Chinese postmenopausal women].
abstract: OBJECTIVE
  To study the serum matrix metalloproteinase-1 (MMP-1), matrix metalloproteinase-2 (MMP-2), and tissue inhibitor of metalloproteinase-1 (TIMP-1) levels, and the correlations of MMP-1, MMP-2, and TIMP-1 with bone turn-over markers and bone mineral density (BMD) in aged postmenopausal Chinese women.
  
  
  METHODS
  The serum MMP-1, MMP-2, TIMP-1, serum bone alkaline phosphatase (BAP), serum osteocalcin (OC), serum cross-linked N-telopeptides of type I collagen (NTX) of 297 Chinese female volunteers aged 48 - 89 were measured using ELISA. BMD were measured using dual energy X-ray absorptiometry in aged postmenopausal Chinese women.
  
  
  RESULTS
  (1) There were no significant negative relationships between MMP-1, TIMP-1 and BMD and bone biochemical markers. (2) A weak negative relationships were found between MMP-2 and BMD. Adjusted by age and body weight, the correlation of MMP-2 with BMD of neck of femur and hip disappeared. (3) Positive correlations between MMP-2 and BAP, OC, NTX was found (all r = 0.193, 0.231, 0.249, P < 0.01) (4) Serum MMP-2 concentrations were significantly higher in postmenopausal women with osteoporosis (1466 microg/L +/- 313 microg/L) than in age-matched normal controls (1222 microg/L +/- 243 microg/L) and osteopenia subjects (1282 microg/L +/- 220 microg/L).
  
  
  CONCLUSIONS
  There are significant correlations between serum MMP-2 and bone metabolism, and MMP-2 may increase with increases in bone-turnover. The increases of serum MMP-2 appear possibly as a concomitant event in high bone turnover state, such as postmenopausal osteoporosis.
authors.affiliation: Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Li-juan
authors.initials: LJ
authors.lastname: Guo
authors.forename: Xiang-hang
authors.initials: XH
authors.lastname: Luo
authors.forename: Xian-ping
authors.initials: XP
authors.lastname: Wu
authors.forename: Hui
authors.initials: H
authors.lastname: Xie
authors.forename: Hou-de
authors.initials: HD
authors.lastname: Zhou
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Xing-zhi
authors.initials: XZ
authors.lastname: Cao
authors.forename: Er-yuan
authors.initials: EY
authors.lastname: Liao
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000378:metabolism; D015519:Bone Density; D016723:Bone Remodeling; D003094:Collagen / Q000097:blood; D024042:Collagen Type I; D005260:Female; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000097:blood*; D020778:Matrix Metalloproteinase 2 / Q000097:blood*; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D015663:Osteoporosis, Postmenopausal / Q000097:blood*; D010455:Peptides / Q000097:blood; D017698:Postmenopause; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood*
chemical_list: D024042:Collagen Type I; D010455:Peptides; D019715:Tissue Inhibitor of Metalloproteinase-1; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D003094:Collagen; D000469:Alkaline Phosphatase; D020778:Matrix Metalloproteinase 2; D020781:Matrix Metalloproteinase 1