Pregnancy in postural orthostatic tachycardia syndrome.
BACKGROUND
Postural orthostatic tachycardia syndrome (POTS) is a rare disease characterized by syncope, sinus tachycardia, and orthostasis due to autonomic dysfunction.


RESULTS
Two women aged 26 and 24 years with severe POTS became pregnant. Both women experienced hyperemesis gravidarum with subsequent marked improvement in their POTS symptoms until 6 months gestation, when their syncope and sinus tachycardia caused clinical decompensation. Both patients delivered healthy babies at 37 weeks by elective cesarean section.


CONCLUSIONS
In long-term follow-up, both women reported improvement in their prepartum symptoms. We describe the first report, to our knowledge, of two successful pregnancy outcomes in severe POTS, including the first report of midodrine use in pregnant women.
Glatter
Kathryn A
KA
Department of Adult Cardiology, University of California-Davis, 4860 Y Street, Suite 2820, Sacramento, CA 95817, USA. k_glatter@yahoo.com
Tuteja
Dipika
D
Chiamvimonvat
Nipavan
N
Hamdan
Mohamed
M
Park
Jeanny K
JK
D000328:Adult; D004244:Dizziness / Q000628:therapy*; D005260:Female; D006801:Humans; D011187:Posture; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000628:therapy*; D011256:Pregnancy Outcome; D013575:Syncope / Q000628:therapy*; D013577:Syndrome; D013610:Tachycardia / Q000628:therapy*