Exercise training in mitochondrial myopathy: a randomized controlled trial.
Patients with mitochondrial myopathies (MM) usually suffer from exercise intolerance due to their impaired oxidative capacity and physical deconditioning. We evaluated the effects of a 12-week supervised randomized rehabilitation program involving endurance training in patients with MM. Twenty MM patients were assigned to a training or control group. For three nonconsecutive days each week, patients combined cycle exercise at 70% of their peak work rate with three upper-body weight-lifting exercises performed at 50% of maximum capacity. Training increased maximal oxygen uptake (28.5%), work output (15.5%), and minute ventilation (40%), endurance performance (62%), walking distance in shuttle walking test (+95 m), and peripheral muscle strength (32%-62%), and improved Nottingham Health Profile scores (21.47%) and clinical symptoms. Control MM patients did not change from baseline. Results show that our exercise program is an adequate training strategy for patients with mitochondrial myopathy.
Cejudo
Pilar
P
Chest Department, Hospital Universitario Virgen del Rocío, 41013 Seville, Spain. pilarcejudo@terra.es
Bautista
Juan
J
Montemayor
Teodoro
T
Villagómez
Rafael
R
Jiménez
Luis
L
Ortega
Francisco
F
Campos
Yolanda
Y
Sánchez
Hildegard
H
Arenas
Joaquín
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy / Q000379:methods*; D017079:Exercise Tolerance / Q000502:physiology*; D005260:Female; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D008297:Male; D008451:Maximal Voluntary Ventilation / Q000502:physiology; D008875:Middle Aged; D017240:Mitochondrial Myopathies / Q000503:physiopathology / Q000628:therapy*; D018908:Muscle Weakness / Q000503:physiopathology / Q000628:therapy*; D018482:Muscle, Skeletal / Q000502:physiology; D010101:Oxygen Consumption / Q000502:physiology; D010809:Physical Fitness / Q000502:physiology*; D011788:Quality of Life; D020127:Recovery of Function / Q000502:physiology; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
D019344:Lactic Acid