Techniques for carotid artery stenting under cerebral protection.
Carotid angioplasty and stenting is an alternative to carotid endarterectomy in the treatment of carotid artery stenosis. During the stenting process, however, distal embolization usually occurs, and the particles released may cause neurologic problems or death. Thus, the safety of carotid stenting depends partly on use of a cerebral protection device during the procedure. Three principal types of protection mechanisms have been developed: distal balloon occlusion, distal filtration, and proximal occlusion with or without reversal of flow. Products using these mechanisms have been manufactured by a variety of companies, and many are used routinely outside the United States (US). One distal filter, the RX Accunet, has been approved by the US Food and Drug Administration for clinical use. Large clinical trials of most of the newest carotid stents and cerebral protection devices are under way, and some initial results have been reported. Several clinical series in which cerebral protection was employed have also been described. Each type of protection device has advantages and disadvantages, which are discussed in this review.
Schönholz
C J
CJ
Heart and Vascular Center, Medical University of South Carolina, Charleston, SC 29425, USA. schonhol@musc.edu
Uflacker
R
R
Mendaro
E
E
Parodi
J C
JC
Guimaraes
M
M
Hannegan
C
C
Selby
B
B
D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects* / Q000295:instrumentation; D016893:Carotid Stenosis / Q000601:surgery*; D004867:Equipment Design; D006801:Humans; D020766:Intracranial Embolism / Q000209:etiology / Q000517:prevention & control*; D015607:Stents; D020521:Stroke / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome