title: Does preloading with colloids prevent hemodynamic changes when neurosurgical patients are subsequently changed to the seated position?
abstract: OBJECTIVE
  This prospective, randomized, double-blind study was designed to determine and compare the usefulness of preloading colloids (Haemaccel) 10 ml/Kg before positioning whether it can prevent hemodynamic changes during seated positioning or not.
  
  
  METHODS
  The authors studied 20 patients by randomly dividing them into 2 groups. The control group was given crystalloid as maintenance and deposit replacement but the study group was given extra colloids 10 ml/Kg 30 minutes before starting general anesthesia. Both groups were monitored and given anesthesia, balanced technique. Systolic and diastolic blood pressures, heart rate, central venous pressure (CVP) at different time intervals in the sitting position for 30 minutes were recorded. Statistical analysis was done by Student t-test, Chi-square test and ANOVA (p-value < 0. 05 considered significant).
  
  
  RESULTS
  The results showed that systolic blood pressure at 15, 20, 30 minutes and CVP at 15, 25, 30 minutes after positioning in the study group was maintained significantly compared to the control group and there were no significant changes in diastolic blood pressure and heart rate. There were no other complications during the sitting period.
  
  
  CONCLUSIONS
  It is concluded that preloading colloid fluid prior to repositioning could prevent the decrease of systolic blood pressure and central venous pressure during sitting positioning without other complications.
authors.affiliation: Department of Anesthesiology, Prasat Neurological Institute, 312 Rajvithee Rd, Rajthevee, Bangkok 10400, Thailand. ppakvp@hotmail.com
authors.forename: Phuping
authors.initials: P
authors.lastname: Akavipat
authors.forename: Paungpaga
authors.initials: P
authors.lastname: Metta
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D005440:Fluid Therapy / Q000379:methods*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D010952:Plasma Substitutes / Q000008:administration & dosage*; D011097:Polygeline / Q000008:administration & dosage*; D011187:Posture / Q000502:physiology*; D011300:Preoperative Care; D011446:Prospective Studies
chemical_list: D010952:Plasma Substitutes; D011097:Polygeline