Influence of the serotonin transporter promoter gene polymorphism on susceptibility to posttraumatic stress disorder.
Posttraumatic stress disorder (PTSD) is a prevalent anxiety disorder marked by behavioral, physiologic, and hormonal alterations. The etiology of PTSD is unknown, although exposure to a traumatic event constitutes a necessary, but not sufficient, factor. Serotonergic dysfunction has been implicated in PTSD. The present study examined the possible association between the serotonin-transporter-linked polymorphic region (SERTPR) and PTSD. The genotype and allele frequencies of the SERTPR were analyzed in 100 PTSD patients and 197 unrelated healthy controls using a case-control design. The frequency of the s/s genotype was significantly higher in PTSD patients than in normal controls. These findings suggest that the SERTPR s/s genotype is one of the genetic factors for the susceptibility to PTSD. Further investigations are required into the influence of gene polymorphisms on the biological mechanisms of PTSD, its clinical expression, and its response to treatment.
Lee
Heon-Jeong
HJ
Department of Psychiatry and Depression Center, Korea University College of Medicine, Seoul, Korea.
Lee
Min-Soo
MS
Kang
Rhee-Hun
RH
Kim
Hyun
H
Kim
Soon-Duck
SD
Kee
Baik-Seok
BS
Kim
Young Hoon
YH
Kim
Yong-Ku
YK
Kim
Jung Bum
JB
Yeon
Byung Kil
BK
Oh
Kang Seob
KS
Oh
Byung-Hoon
BH
Yoon
Jin-Sang
JS
Lee
Chul
C
Jung
Han Yong
HY
Chee
Ik-Seung
IS
Paik
In Ho
IH
D000328:Adult; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics* / Q000502:physiology; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics* / Q000502:physiology; D013313:Stress Disorders, Post-Traumatic / Q000235:genetics* / Q000503:physiopathology*
D050486:Serotonin Plasma Membrane Transport Proteins