Long-term parathyroid- and c-cell function after radioiodine for benign thyroid diseases.
The study examined static and dynamic parathyroid hormone and calcitonin secretion after radioiodine, and was a retrospective study of patients having received radioiodine for benign conditions 8-12 years earlier. In one group of patients parathyroid hormone and calcium were measured as single blood tests, in a second group of patients parathyroid hormone and calcitonin secretion capacity were measured during a hypocalcaemic citrate-clamp and a hypercalcaemic stimulation test. Baseline calcium and parathyroid hormone were normal within expected ranges 8-12 years after radioiodine. Stimulated parathyroid hormone or calcitonin secretion did not differ from an age- and gender-matched control group. Radioiodine in doses used for benign thyroid diseases appears safe with regard to parathyroid hormone and calcitonin secretion.
Mortensen
Lene S
LS
Viborg County Hospital, Department of Internal Medicine, Viborg, Denmark.
Smidt
Kamille
K
Jørgensen
Anette
A
Nielsen
Jørn Theil
JT
Laurberg
Peter
P
Søndergaard
Liselotte
L
Rungby
Jørgen
J
D000368:Aged; D002116:Calcitonin / Q000097:blood; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010280:Parathyroid Glands / Q000503:physiopathology / Q000528:radiation effects*; D010281:Parathyroid Hormone / Q000097:blood; D012189:Retrospective Studies; D013959:Thyroid Diseases / Q000503:physiopathology / Q000532:radiotherapy*; D013961:Thyroid Gland / Q000503:physiopathology / Q000528:radiation effects*
D007457:Iodine Radioisotopes; D010281:Parathyroid Hormone; D002116:Calcitonin; D002118:Calcium