title: One-year angiotensin-converting enzyme inhibition plus mycophenolate mofetil immunosuppression in the course of early IgA nephropathy: a multicenter, randomised, controlled study.
abstract: Angiotensin converting-enzyme inhibition (ACEI) is a widely accepted treatment during established renal diseases and beneficial effects have also been reported in IgA nephropathy (IgAN). Immunosuppression with myco-phenolate mofetil (MMF) has recently been introduced in the treatment of immune-mediated renal diseases showing promising results. Preliminary clinical reports are also suggestive that MMF is effective in severe forms of IgAN. We propose a randomised prospective trial aimed to compare long-term renal survival of early IgAN in the course of ACEI therapy with or without MMF immunosuppression.
authors.affiliation: Unit of Nephrology, Dialysis and Transplantation, IRCCS Policlinico San Matteo and University of Pavia, Pavia. dalcanton@mbox.medit.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Dal Canton
authors.forename: Amore
authors.initials: A
authors.lastname: Amore
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Barbano
authors.forename: Rosanna
authors.initials: R
authors.lastname: Coppo
authors.forename: Francesco
authors.initials: F
authors.lastname: Emma
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Grandaliano
authors.forename: Catherine
authors.initials: C
authors.lastname: Klersy
authors.forename: Francesco
authors.initials: F
authors.lastname: Perfumo
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Rizzoni
authors.forename: Francesco Paolo
authors.initials: FP
authors.lastname: Schena
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Sepe
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage*; D002648:Child; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005922:Glomerulonephritis, IGA / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009173:Mycophenolic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D013997:Time Factors
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid