title: Electrostatic control of aromatic stacking interactions.
abstract: A supramolecular approach has been used to investigate the free energies of intermolecular aromatic stacking interactions. Chemical double mutant cycles have been used to measure the effect of a range of substituents on face-to-face stacking interactions with phenyl and pentafluorophenyl rings. Electrostatic effects dominate the trends in interaction energy.
authors.affiliation: Centre for Chemical Biology, Department of Chemistry, Krebs Institute for Biomolecular Science, University of Sheffield, Sheffield S3 7HF, U.K.
authors.forename: Scott L
authors.initials: SL
authors.lastname: Cockroft
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Hunter
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Lawson
authors.forename: Julie
authors.initials: J
authors.lastname: Perkins
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Urch
mesh_terms: D004247:DNA / Q000737:chemistry; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D006860:Hydrogen Bonding; D008958:Models, Molecular; D055672:Static Electricity; D013816:Thermodynamics
chemical_list: D006841:Hydrocarbons, Aromatic; D004247:DNA