title: Transient increase of plasma ghrelin after laparoscopic adjustable gastric banding in morbid obesity.
abstract: Ghrelin is a peptide hormone with orexigenic properties that is produced by the stomach. Ghrelin and leptin are thought to be the main regulators of appetite and body weight. The present study was aimed at evaluating the effect of weight reduction after laparoscopic adjustable gastric banding (LAGB) on metabolic parameters and energy balance regulatory peptides. Patients were evaluated before and 6, 12, 24 or 36 months after the procedure, and a blood sample was obtained. Ghrelin rose 6 and 12 months after LABG, and then returned to near-baseline levels. In our study, the correlation between ghrelin and BMI was weak, but a strong significant correlation was maintained between leptin and BMI. We conclude that ghrelin is mainly stimulated by the negative caloric balance, and hypothesize that ghrelin is involved in maintaining a stable body weight, while leptin signals the body energy store; both hormones together are part of a more complex feedback mechanism.
authors.affiliation: Department of Internal Medicine, Tor Vergata University of Rome, Italy.
authors.forename: L M
authors.initials: LM
authors.lastname: Mariani
authors.forename: A
authors.initials: A
authors.lastname: Fusco
authors.forename: M
authors.initials: M
authors.lastname: Turriziani
authors.forename: A
authors.initials: A
authors.lastname: Veneziani
authors.forename: M A
authors.initials: MA
authors.lastname: Marini
authors.forename: A
authors.initials: A
authors.lastname: de Lorenzo
authors.forename: A
authors.initials: A
authors.lastname: Bertoli
mesh_terms: D000328:Adult; D001066:Appetite / Q000502:physiology; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D015391:Gastroplasty; D054439:Ghrelin; D006728:Hormones / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D010535:Laparoscopy; D020738:Leptin / Q000097:blood; D008297:Male; D009767:Obesity, Morbid / Q000097:blood*; D036361:Peptide Hormones / Q000097:blood*; D013997:Time Factors
chemical_list: D054439:Ghrelin; D006728:Hormones; D007328:Insulin; D020738:Leptin; D036361:Peptide Hormones; D007334:Insulin-Like Growth Factor I