title: Evaluation of a semiautomatic software tool for left ventricular function analysis with 16-slice computed tomography.
abstract: The purpose of the study was to evaluate a semiautomatic analysis tool for assessing global left ventricular myocardial function with multislice computed tomography (MSCT). We examined 33 patients with MSCT using 16x0.5 mm detector collimation and magnetic resonance imaging (MRI) on a 1.5-T scanner. MSCT data were analyzed using semiautomatic volumetric analysis software (ANET, CSCF-001A, Toshiba). This software tool automatically creates endo- and epicardial contours that can be manually corrected on all short-axis slices at all reconstructed time points within the cardiac cycle, based on a contour-detection and density-threshold algorithm. All global left ventricular function parameters assessed with the semiautomatic MSCT software were highly correlated with the results of MRI. Bland-Altman analysis showed minor systematic overestimation of end-diastolic (10.7 ml) and end-systolic volumes (5.6 ml) and underestimation of ejection fraction (2.1%) with MSCT as compared with MRI. The post-processing time was moderately but significantly longer with the MSCT software (15.9+/-2.8 min) than necessary for MRI (14.0+/-2.5 min, P<0.01), mainly as a result of the longer time required for uploading of the MSCT datasets, which were on average 54 times larger (1.3 GByte). In conclusion, it appears feasible to accurately assess global left ventricular function with MSCT in a reasonable post-processing time using a semiautomatic software tool.
authors.affiliation: Department of Radiology, Charité, Medical School, Humboldt-Universität zu Berlin, Schumannstr. 20/21, 10117, Berlin, Germany. marc.dewey@charite.de
authors.forename: Marc
authors.initials: M
authors.lastname: Dewey
authors.forename: Mira
authors.initials: M
authors.lastname: Müller
authors.forename: Florian
authors.initials: F
authors.lastname: Teige
authors.forename: Bernd
authors.initials: B
authors.lastname: Hamm
mesh_terms: D003287:Contrast Media / Q000008:administration & dosage; D003327:Coronary Disease / Q000175:diagnosis*; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D011856:Radiographic Image Enhancement / Q000379:methods; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014283:Triiodobenzoic Acids; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; C044834:iodixanol