title: Ability of a new oral nicotine substitute to reduce smoking urge in moderate smokers.
abstract: The aim of this study was to assess the effectiveness of a new nicotine lozenge ( Nicopass 1.5 mg) in reducing smoking urge after an overnight abstinence. Twenty-four moderate smokers participated in a randomized, double-blind, placebo-controlled, 2-period crossover trial. The results showed that 1.5 mg-nicotine lozenge is superior to placebo in reducing smoking urge (p = 0.0001). In addition, nicotine lozenge, but not placebo, significantly improved vigilance and psychomotor performances (p < 0.05) and displayed a cardiac chronotropic effect. Thus, the 1.5-mg nicotine lozenge appears as an effective aid to alleviate acute tobacco withdrawal symptoms in moderate smokers.
authors.affiliation: FORENAP Research Institute for Neuroscience, Pharmacology and Psychiatry, 27 rue du 4eme RSM, 68250 Rouffach, France. agnes.demazieres@forenap.asso.fr
authors.forename: A
authors.initials: A
authors.lastname: Demazières
authors.forename: R
authors.initials: R
authors.lastname: Luthringer
authors.forename: E
authors.initials: E
authors.lastname: Coppel
authors.forename: C
authors.initials: C
authors.lastname: Gilles
authors.forename: C
authors.initials: C
authors.lastname: Fleury
authors.forename: J C
authors.initials: JC
authors.lastname: Roegel
authors.forename: A
authors.initials: A
authors.lastname: Delarue
authors.forename: C
authors.initials: C
authors.lastname: Laur
authors.forename: G
authors.initials: G
authors.lastname: Lagrue
mesh_terms: D000284:Administration, Oral; D000328:Adult; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D009538:Nicotine / Q000627:therapeutic use*; D018722:Nicotinic Agonists / Q000627:therapeutic use*; D011597:Psychomotor Performance / Q000187:drug effects; D012907:Smoking / Q000009:adverse effects / Q000188:drug therapy* / Q000523:psychology; D016540:Smoking Cessation / Q000379:methods*; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy* / Q000209:etiology
chemical_list: D018722:Nicotinic Agonists; D009538:Nicotine