Transglutaminase and diseases of the central nervous system.
Alzheimer's disease, Parkinson's disease and diseases of expanded polyglutamine are associated with insoluble protein aggregates and neuronal death. A role for transglutaminase in the stabilization of these aggregates has been proposed. Diseases of polyglutamine expansion have been the most thoroughly investigated and a large body of studies supports the causative role of transglutaminase in aggregation of expanded polyglutamine. However none of the evidence is conclusive. Indisputable evidence of cross-linking by transglutaminase will be required in order to provide firm support for therapeutic measures based on the role of transglutaminase.
Hoffner
Guylaine
G
UPR 2228 CNRS, Institut Interdisciplinaire des Sciences du Vivant, Université René Descartes, 45, rue des Saints-Pères, 75270 Paris Cedex 06, France.
Djian
Philippe
P
D000544:Alzheimer Disease / Q000201:enzymology / Q000378:metabolism; D006801:Humans; D006816:Huntington Disease / Q000201:enzymology / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000201:enzymology / Q000378:metabolism*; D010300:Parkinson Disease / Q000201:enzymology / Q000378:metabolism; D010455:Peptides / Q000378:metabolism / Q000502:physiology*; D011503:Transglutaminases / Q000378:metabolism*
D010455:Peptides; C097188:polyglutamine; D011503:Transglutaminases