Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part II. Copolymers with positive and negative charges, polyelectrolyte complexes.
Crosslinked macroporous hydrogels based on 2-hydroxyethyl methacrylate (HEMA)-[2-(methacryloyloxy)ethyl]trimethylammonium chloride (MOETACl) copolymer, HEMA-MOETACl-methacrylic acid (MA) terpolymer, and on a polyelectrolyte complex of HEMA-MA copolymer with poly(MOETACl) were prepared. All the hydrogels were prepared in the presence of fractionated sodium chloride particles. The hydrogels were characterized by the number of pores and the total volume of all pores in unit volume, the average volume and the average diameter of single pore. Morphology of the hydrogels was investigated by confocal and scanning electron microscopy. The hydrogels based on polyelectrolyte complexes were also characterized by chemical composition. Homogeneous (non-porous) hydrogels with the same composition as macroporous hydrogels were prepared and characterized by their biocompatibility.
Prádný
M
M
Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, 162 06, Prague 6, Czech Republic. pradny@imc.cas.cz
Lesný
P
P
Smetana
K
K
Vacík
J
J
Slouf
M
M
Michálek
J
J
Syková
E
E
D000818:Animals; D001672:Biocompatible Materials / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology; D003238:Connective Tissue / Q000187:drug effects* / Q000648:ultrastructure*; D004573:Electrolytes / Q000032:analysis / Q000737:chemistry; D020100:Hydrogels / Q000032:analysis / Q000737:chemistry* / Q000494:pharmacology*; D046911:Macromolecular Substances / Q000032:analysis / Q000737:chemistry; D008297:Male; D008422:Materials Testing; D008689:Methacrylates / Q000032:analysis / Q000737:chemistry* / Q000494:pharmacology*; D011108:Polymers / Q000032:analysis / Q000737:chemistry; D016062:Porosity; D051381:Rats; D055672:Static Electricity; D013499:Surface Properties
D001672:Biocompatible Materials; D004573:Electrolytes; D020100:Hydrogels; D046911:Macromolecular Substances; D008689:Methacrylates; D011108:Polymers; C005044:hydroxyethyl methacrylate