Small hepatocellular carcinoma associated with Wilson's disease.
We report a 66-year-old male patient with hepatocellular carcinoma (HCC) associated with Wilson's disease. The patient presented with unresolving abnormal liver function test, decreased serum ceruloplasmin levels and increased 24-hour urine copper excretion. Liver biopsy specimen revealed the presence of increased levels of copper and features suggestive of Wilson's disease. Abdominal imaging showed the existence of a small HCC. Three years after chemoembolization and microwave coagulation therapy for HCC, he died of hepatic failure, which apparently resulted from chemoembolization. Patients with Wilson's disease should be screened for HCC. We should elude therapies such as chemoembolization in these patients.
Kumagi
Teru
T
Third Department of Internal Medicine, Ehime University School of Medicine, Japan.
Horiike
Norio
N
Abe
Masanori
M
Kurose
Kiyotaka
K
Iuchi
Hideto
H
Masumoto
Toshikazu
T
Joko
Koji
K
Akbar
Sk Fazle
SF
Michitaka
Kojiro
K
Onji
Morikazu
M
D001706:Biopsy; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D002570:Ceruloplasmin / Q000378:metabolism; D016461:Chemoembolization, Therapeutic; D003300:Copper / Q000652:urine; D003937:Diagnosis, Differential; D003972:Diathermy / Q000379:methods; D017809:Fatal Outcome; D006527:Hepatolenticular Degeneration / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008113:Liver Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D008297:Male; D008872:Microwaves; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
D003300:Copper; D002570:Ceruloplasmin