Enantioseparation of the esters of alpha-N-acetyl amino acids by lipase in ionic liquid.
Chiral alpha-amino acids have been obtained via enzymatic resolution in ionic liquid medium. The acetyl esters of a series of amino acids were separated by enzyme porcine pancreas lipase (PPL) in an aqueous solution of N-ethyl pyridinium trifluoroacetate, [EtPy]+ [CF3OO]-. A comparative study with organic solvent acetonitrile shows that the ionic liquids provide a better medium for enzymatic resolution.
Malhotra
Sanjay V
SV
Department of Chemistry and Environmental Science, New Jersey Institute of Technology, University Heights, Newark, New Jersey, USA. malhotra@njit.edu
Zhao
Hua
H