title: Animal models of premature and retarded ejaculation.
abstract: Most of our current understanding of the neurobiology of sexual behavior and ejaculatory function has been derived from animal studies using rats with normal sexual behaviour. However, none of these proposed models adequately represents human ejaculatory disorders. Based on the "ejaculation distribution theory", which postulates that the intravaginal ejaculation latency time in men is represented by a biological continuum, we have developed an animal model for the research of premature and delayed ejaculation. In this model, a large number of male Wistar rats are investigated during 4-6 weekly sexual behavioural tests. Based on the number of ejaculations during 30 min tests, rapid and sluggish ejaculating rats are distinguished, each representing approximately 10% at both ends of a Gaussian distribution. Together with other parameters, such as ejaculation latency time, these rats at either side of the spectrum resemble men with premature and delayed ejaculation, respectively. Comparable to the human situation, in a normal population of rats, endophenotypes exist with regard to basal sexual (ejaculatory) performance.
authors.affiliation: Department of Psychiatry and Neurosexology, Leyenburg Haga Hospital, Leyweg 275, 2545 CH The Hague, The Netherlands. md@waldinger.demon.nl
authors.forename: Marcel D
authors.initials: MD
authors.lastname: Waldinger
authors.forename: Berend
authors.initials: B
authors.lastname: Olivier
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004542:Ejaculation; D008297:Male; D012701:Serotonin / Q000378:metabolism; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D012726:Sexual Behavior, Animal / Q000502:physiology*; D012735:Sexual Dysfunction, Physiological / Q000378:metabolism / Q000503:physiopathology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
chemical_list: D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors