title: First description of DHA-1 ampCbeta-lactamase in Proteus mirabilis.
abstract: This report describes the first occurrence of the DHA-1 ampCbeta-lactamase gene in Proteus mirabilis. The organism was isolated from the vaginal flora of a pregnant woman in a French hospital. The DHA-1 beta-lactamase gene was identified on the basis of phenotypic characteristics, PCR amplification and sequencing. Antagonism between cefoxitin and the other cephalosporins suggested inducible production of the DHA-1 enzyme.
authors.affiliation: Laboratoire d'Etudes de Génétique Bactérienne dans les Infections de l'Enfant (EA 3105), Université Denis Diderot-Paris VII, Service de Microbiologie, Hôpital Robert Debré, Paris, France. philippe.bidet@rdb.ap-hop-paris.fr
authors.forename: P
authors.initials: P
authors.lastname: Bidet
authors.forename: C
authors.initials: C
authors.lastname: Verdet
authors.forename: V
authors.initials: V
authors.lastname: Gautier
authors.forename: E
authors.initials: E
authors.lastname: Bingen
authors.forename: G
authors.initials: G
authors.lastname: Arlet
mesh_terms: D000328:Adult; D001426:Bacterial Proteins / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism; D005260:Female; D005602:France; D006801:Humans; D008826:Microbial Sensitivity Tests; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011513:Proteus mirabilis / Q000187:drug effects / Q000201:enzymology* / Q000302:isolation & purification; D014621:Vagina / Q000382:microbiology; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism; D047090:beta-Lactams / Q000494:pharmacology
chemical_list: D001426:Bacterial Proteins; D047090:beta-Lactams; C048795:AmpC beta-lactamases; D001618:beta-Lactamases