title: One-year cyclophosphamide treatment combined with methylprednisolone improves cognitive dysfunction in progressive forms of multiple sclerosis.
abstract: We conducted an evaluation of changes in cognition in progressive multiple sclerosis (MS) patients receiving monthly intravenously pulse of cyclophosphamide (700 mg/m2) with methylprednisolone (1g). Twenty-eight consecutive progressive MS patients (10 primary progressive, 18 secondary progressive MS) were evaluated before and after six and 12 months of treatment. The WAIS-R score, memory and executive functions were evaluated. Under treatment we found a significant improvement in global cognitive efficiency, encoding abilities, planning abilities and inhibition after six and 12 months. However, mechanisms of action of the positive effect of these anti-inflammatory and immunosuppressive treatments on cognition remain unclear.
authors.affiliation: Department of Neurology, Hôpital Roger Salengro, University of Lille II and CHR, 59047 Lille, France. helenez@nomade.fr
authors.forename: H
authors.initials: H
authors.lastname: Zéphir
authors.forename: J
authors.initials: J
authors.lastname: de Seze
authors.forename: K
authors.initials: K
authors.lastname: Dujardin
authors.forename: G
authors.initials: G
authors.lastname: Dubois
authors.forename: M
authors.initials: M
authors.lastname: Cabaret
authors.forename: S
authors.initials: S
authors.lastname: Bouillaguet
authors.forename: D
authors.initials: D
authors.lastname: Ferriby
authors.forename: T
authors.initials: T
authors.lastname: Stojkovic
authors.forename: P
authors.initials: P
authors.lastname: Vermersch
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D003071:Cognition / Q000187:drug effects; D003072:Cognition Disorders / Q000188:drug therapy* / Q000209:etiology; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008775:Methylprednisolone / Q000008:administration & dosage*; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000150:complications / Q000188:drug therapy*; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D008775:Methylprednisolone