Aging and T cell development: interplay between progenitors and their environment.
Thymic involution is the hallmark of hematopoietic aging. Because T cell differentiation is a multistep process that occurs non-cell autonomously, aging defects can occur at multiple points along the developmental pathway, both in the T progenitors themselves and in the thymic stromal cells that support their development. Here we review the evidence for age-related thymopoiesis defects at key steps in the production of naïve mature T cells, highlighting the importance of the interaction between stromal aging and progenitor aging.
Zediak
Valerie P
VP
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, 264 John Morgan Building, Philadelphia, PA 19104, USA.
Bhandoola
Avinash
A
D000375:Aging / Q000276:immunology*; D000818:Animals; D002450:Cell Communication / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology*; D016922:Cellular Senescence / Q000276:immunology*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology*; D006801:Humans; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology*