Congenital aganglionosis in a 3-day-old Holstein calf.
Necropsy of a 3-day-old Holstein heifer revealed proximal megacolon and distal colorectal hypoplasia. Histologically, the hypoplastic distal colon and rectum lacked submucosal and myenteric ganglia. Clinical history, physical examination, and pathologic findings were consistent with intestinal aganglionosis, a congenital anomaly well documented in humans and foals but not previously reported in cattle.
Forzán
Maria J
MJ
Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island. mariaforzan@hotmail.com
McClure
J T
JT
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000151:congenital / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006627:Hirschsprung Disease / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary