Soluble mesothelin-related protein--a blood test for mesothelioma.
Identification of tumor marker for mesothelioma (MM) might prove useful in diagnosis as well as for monitoring tumor in response to therapy and for screening at-risk individuals. We tested the hypothesis that soluble mesothelin-related protein (SMRP), a mesothelin family member, in the serum would be such a marker. Our data show that determination of SMRP in serum is a marker of MM with a sensitivity of sensitivity 83% and specificity 95% in the first 48 MM patients tested. Changes in serum SMRP levels parallel clinical course/tumor size and SMRP is elevated in 75% of patients at diagnosis. SMRP should also be useful for monitoring disease progression, and importantly, may prove useful for screening asbestos-exposed individuals for early MM.
Robinson
Bruce W S
BW
University Department of Medicine, University of Western Australia, Queen Elizabeth II Medical Centre, Perth, WA, Australia. bwsrobin@cyllene.uwa.edu.au
Creaney
Jenette
J
Lake
Richard
R
Nowak
Anna
A
Musk
Arthur William
AW
de Klerk
Nicholas
N
Winzell
Pernilla
P
Hellstrom
Karl Erik
KE
Hellstrom
Ingegerd
I
D000328:Adult; D001194:Asbestos / Q000009:adverse effects; D014408:Biomarkers, Tumor / Q000097:blood*; D058851:GPI-Linked Proteins; D006801:Humans; D008171:Lung Diseases / Q000209:etiology / Q000503:physiopathology; D008562:Membrane Glycoproteins / Q000097:blood*; D000090204:Mesothelin; D008654:Mesothelioma / Q000097:blood / Q000175:diagnosis*; D010997:Pleural Neoplasms / Q000097:blood / Q000175:diagnosis*
D014408:Biomarkers, Tumor; D058851:GPI-Linked Proteins; D008562:Membrane Glycoproteins; D001194:Asbestos; D000090204:Mesothelin