Oxidants and antioxidants in tonsillar and adenoidal tissue in chronic adenotonsillitis and adenotonsillar hypertrophy in children.
OBJECTIVE
The aim of the study is to determine the possible role of oxidants and antioxidants in the pathogenesis of chronic adenotonsillitis and adenotonsillar hypertrophy in children.


METHODS
The children were divided into infection and hypertrophy groups, which were comparable according to age and gender distribution. The infection group was consisted of 20 children with the diagnosis of chronic adenotonsillitis and the hypertrophy group was made up of 19 children with adenotonsillar hypertrophy to whom adenotonsillectomy was performed. Preoperative blood levels of erythrocyte MDA, serum MDA, erythrocyte catalase and serum catalase, and adenoidal and tonsillar tissue levels of MDA and catalase were studied.


RESULTS
There were significant increase in tonsil MDA, adenoid MDA, tonsil catalase and adenoid catalase levels in infection group (p<0.05).


CONCLUSIONS
Oxidants and antioxidants are found to have an important role in the pathogenesis of adenotonsillar hypertrophy and chronic adenotonsillitis. These findings strengthen the hypothesis that indicates adenotonsillar hypertrophy and chronic adenotonsillitis are different diseases of the same tissues.
Kiroglu
A Faruk
AF
Yüzüncü Yil University, School of Medicine, Department of Otolaryngology, Van, Turkey. fkiroglu@email.com
Noyan
Tevfik
T
Oger
Muzaffer
M
Kara
Tolga
T
D000234:Adenoids / Q000378:metabolism / Q000473:pathology*; D000293:Adolescent; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000097:blood / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006801:Humans; D006984:Hypertrophy / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D016877:Oxidants / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D014066:Palatine Tonsil / Q000378:metabolism / Q000473:pathology*; D014069:Tonsillitis / Q000378:metabolism / Q000473:pathology*
D000975:Antioxidants; D016877:Oxidants; D008315:Malondialdehyde; D002374:Catalase