title: Successful reduced-intensity stem cell transplantation (RIST) for a patient with malignant lymphoma and an ileostomy.
abstract: A 56-year-old man was admitted for treatment of non-Hodgkin's lymphoma (NHL). He had undergone a partial small bowel and colon resection and had ileostomy due to bowel perforation induced by chemotherapy. After the operation, his disease status was in partial remission (PR), and reduced-intensity allogeneic stem cell transplantation (RIST) was therefore performed for further improvement of disease status. The conditioning regimen consisted of fludarabine and busulfan. Graft-versus-host disease (GVHD) prophylaxis was performed using cyclosporin and short-term methotrexate. The occurrence of serious infection during the period of neutropenia was prevented by the administration of amphotericin B, fluconazole and acyclovir. This case report provides important information on the appropriate strategy for treating patients who have ileostomy.
authors.affiliation: Department of Hematology and Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Toubai
authors.forename: Junji
authors.initials: J
authors.lastname: Tanaka
authors.forename: Shuichi
authors.initials: S
authors.lastname: Ota
authors.forename: Akio
authors.initials: A
authors.lastname: Mori
authors.forename: Makoto
authors.initials: M
authors.lastname: Ibata
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Shono
authors.forename: Shinobu
authors.initials: S
authors.lastname: Mashiko
authors.forename: Junichi
authors.initials: J
authors.lastname: Sugita
authors.forename: Yoko
authors.initials: Y
authors.lastname: Miura
authors.forename: Naoko
authors.initials: N
authors.lastname: Kato
authors.forename: Shintaro
authors.initials: S
authors.lastname: Umehara
authors.forename: Kaoru
authors.initials: K
authors.lastname: Kahata
authors.forename: Nobuyasu
authors.initials: N
authors.lastname: Toyoshima
authors.forename: Masahiro
authors.initials: M
authors.lastname: Asaka
authors.forename: Masahiro
authors.initials: M
authors.lastname: Imamura
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects; D001706:Biopsy; D003106:Colon / Q000000981:diagnostic imaging / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D007081:Ileostomy; D007416:Intestinal Perforation / Q000139:chemically induced / Q000175:diagnosis / Q000601:surgery*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D008297:Male; D008482:Mediastinum / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D049268:Positron-Emission Tomography; D012422:Rupture, Spontaneous; D033581:Stem Cell Transplantation / Q000379:methods*; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents