Confocal microscopy of posterior polymorphous endothelial dystrophy.
OBJECTIVE
To report the in vivo confocal microscopic findings of posterior polymorphous endothelial dystrophy (PPED).


METHODS
Four patients with PPED from 2 unrelated families and 2 asymptomatic children of an index patient were included in this observational case series. The eyes of the 6 subjects were examined by confocal light microscopy.


RESULTS
Confocal microscopy demonstrated craters, streaks, and cracks over the corneal endothelium surface. Pleomorphism and polymegathism were present in eyes with PPED. Guttae and clusters of abnormal endothelial cells were also identified in corneas of these PPED patients. These findings were absent in eyes without clinical manifestations of PPED.


CONCLUSIONS
In vivo confocal microscopy is potentially useful for excluding suspected cases of subclinical PPED. Abnormalities in the Descemet membrane and endothelium were observed.
Cheng
Lulu L
LL
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong.
Young
Alvin L
AL
Wong
Angus K K
AK
Law
Ricky W K
RW
Lam
Dennis S C
DS
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003317:Corneal Dystrophies, Hereditary / Q000473:pathology*; D003886:Descemet Membrane / Q000473:pathology*; D004728:Endothelium, Corneal / Q000473:pathology*; D005260:Female; D006801:Humans; D018613:Microscopy, Confocal