title: Deep vein thrombosis and pulmonary embolism reported in the Prescription Event Monitoring Study of Yasmin.
abstract: OBJECTIVE
  To evaluate cases of deep vein thrombosis (DVT) and pulmonary embolism (PE) reported in a prescription event monitoring study of Yasmin, an oral contraceptive.
  
  
  METHODS
  Reports of DVT/PE and events suggestive of DVT/PE were followed up by questionnaire.
  
  
  RESULTS
  Thirteen cases (DVT five; PE eight), each with possible risk factor(s), were identified in 15 645 females using Yasmin. Applying complete case analysis, the crude incidence rate was 13.7 cases per 10 000 woman-years (95% confidence interval 7.3, 23.4).
  
  
  CONCLUSIONS
  Yasmin is associated with venous thromboembolism. An incidence rate has been calculated, but this may be subject to bias and should be interpreted with caution.
authors.affiliation: Drug Safety Research Unit, Bursledon Hall, Blundell Lane, Southampton, UK.
authors.forename: Hilary M
authors.initials: HM
authors.lastname: Pearce
authors.forename: Deborah
authors.initials: D
authors.lastname: Layton
authors.forename: Lynda V
authors.initials: LV
authors.lastname: Wilton
authors.forename: Saad A W
authors.initials: SA
authors.lastname: Shakir
mesh_terms: D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects*; D011307:Drug Prescriptions; D005260:Female; D006801:Humans; D011655:Pulmonary Embolism / Q000139:chemically induced*; D012307:Risk Factors; D011795:Surveys and Questionnaires; D020246:Venous Thrombosis / Q000139:chemically induced*
chemical_list: D003277:Contraceptives, Oral, Combined