Three brothers with a very-late-onset writer's cramp.
Writer's cramp (WC) is a form of focal task-specific dystonia, which is brought on by writing. Although most cases are sporadic, a positive family history is present in 5% to 20% of cases. To date, WC has been reported in several families with primary torsion dystonia, including DYT7, a pure focal dystonia, and in the mixed dystonias, DYT1, DYT6, and DYT13. We describe a family of Bulgarian descent with three brothers presenting with a very-late-onset dystonic WC, compatible with linkage to chromosome 18p.
Bhidayasiri
Roongroj
R
Department of Neurology, UCLA Medical Center, Geffen School of Medicine, University of California, Los Angeles, California 90095, USA. rbh@ucla.edu
Jen
Joanna C
JC
Baloh
Robert W
RW
D000367:Age Factors; D000368:Aged; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D004247:DNA / Q000032:analysis; D004422:Dystonia Musculorum Deformans / Q000235:genetics / Q000503:physiopathology; D020821:Dystonic Disorders / Q000235:genetics* / Q000503:physiopathology*; D005819:Genetic Markers; D006801:Humans; D008297:Male; D018832:Molecular Chaperones / Q000235:genetics; D012720:Severity of Illness Index
D005819:Genetic Markers; D018832:Molecular Chaperones; C108175:TOR1A protein, human; D004247:DNA