title: Cyclin degradation: don't mes(s) with meiosis.
abstract: Cyclin degradation is required for exit from mitosis and enables a new round of DNA replication in the subsequent S phase. A recent study in fission yeast shows that, during exit from meiosis I, the Mes1 protein partially inhibits cyclin degradation and thereby allows entry into meiosis II without an intervening S phase.
authors.affiliation: Research Institute of Molecular Pathology (IMP), A-1030 Vienna, Austria.
authors.forename: Jan-Michael
authors.initials: JM
authors.lastname: Peters
mesh_terms: D064173:Anaphase-Promoting Complex-Cyclosome; D064199:Cdc20 Proteins; D018797:Cell Cycle Proteins / Q000378:metabolism; D016213:Cyclins / Q000378:metabolism*; D008540:Meiosis; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D029702:Schizosaccharomyces pombe Proteins / Q000235:genetics / Q000378:metabolism*; D043743:Ubiquitin-Protein Ligase Complexes / Q000235:genetics / Q000378:metabolism
chemical_list: C577495:CDC20 protein, S cerevisiae; D064199:Cdc20 Proteins; D018797:Cell Cycle Proteins; D016213:Cyclins; C432695:Mes1 protein, S pombe; D029701:Saccharomyces cerevisiae Proteins; D029702:Schizosaccharomyces pombe Proteins; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome