title: Canalicular adenoma arising in the upper lip: review of the pathological findings.
abstract: This case report describes a rare case of canalicular adenoma arising in the upper lip of a 61-year-old male patient. Macroscopic examination of the tumor revealed a well-defined, smooth, firm, elastic hard, round nodule with a diameter of 1.0 cm. The cut surface was white. Histopathology showed that the tumor was an encapsulated mass with a complex cellular pattern of anastomosing duct-like or trabecular structures lined by a single layer of tall columnar epithelial cells, which were embedded in a loose, fibrous, and highly vascular connective tissue stroma. The tumor cells were immunoreactive to AE1/AE3, CK19 and S-100, were partially positive for CK7, CK8, GFAP and PCNA, but were negative for SMA, CK13, CK14 and vimentin.
authors.affiliation: Department of Clinical Pathophysiology, Oral Health Science Center; Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba 261-8502, Japan. matsuzak@tdc.ac.jp
authors.forename: Kenichi
authors.initials: K
authors.lastname: Matsuzaka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Murakami
authors.forename: Masaki
authors.initials: M
authors.lastname: Shimono
authors.forename: Takashi
authors.initials: T
authors.lastname: Inoue
mesh_terms: D000236:Adenoma / Q000473:pathology*; D003238:Connective Tissue / Q000473:pathology; D004847:Epithelial Cells / Q000473:pathology; D006801:Humans; D008048:Lip Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000473:pathology*