title: [The place of cardiac glycosides in the treatment of chronic heart failure].
abstract: In a series of papers the authors analyze literature data on the use of cardiac glycosides for long term treatment of chronic heart failure. Part 1 is devoted to clinical pharmacology of glycosides with special emphasis on digoxin. In low doses digoxin produces no substantial effect on contractility of left ventricular myocardium but can cause worsening of its diastolic function. Favorable action of digoxin on clinical course and outcomes of chronic heart failure is most probably related to modulation of neuro-humoral systems. Data on factors influencing sensitivity to glycosides in various categories of patients with heart failure, their interaction with other drugs, and contraindications for digoxin are also presented.
authors.forename: B A
authors.initials: BA
authors.lastname: Sidorenko
authors.forename: D V
authors.initials: DV
authors.lastname: Preobrazhenskiĭ
authors.forename: I A
authors.initials: IA
authors.lastname: Sharoshina
authors.forename: S A
authors.initials: SA
authors.lastname: Makhmutodzhaev
authors.forename: T A
authors.initials: TA
authors.lastname: Batyraliev
authors.forename: I V
authors.initials: IV
authors.lastname: Pershukov
mesh_terms: D002301:Cardiac Glycosides / Q000627:therapeutic use*; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D004077:Digoxin / Q000627:therapeutic use; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D016896:Treatment Outcome
chemical_list: D002301:Cardiac Glycosides; D002316:Cardiotonic Agents; D004077:Digoxin