title: Improvement of occipital alpha activity by repetitive hyperbaric oxygen therapy in patients with carbon monoxide poisoning: a possible indicator for treatment efficacy.
abstract: OBJECTIVE
  The main aim of this study was to evaluate the efficacy of repetitive hyperbaric oxygen (HBO) treatments with monitoring of quantitative electroencephalography (qEEG) for symptoms of acute carbon monoxide (CO) poisoning and prevention of delayed neuropsychiatric sequelae.
  
  
  METHODS
  Eight patients with acute CO poisoning received repetitive HBO treatments five times a week and qEEG was recorded once a week. Peak alpha frequency, peak alpha power, and absolute and relative alpha power in the occipital region were evaluated. The repetitive HBO treatments were discontinued when the peak alpha frequency increased to and maintained a maximum in each patient.
  
  
  RESULTS
  The mean number of HBO treatments was 20.3. The peak alpha frequency and the relative alpha power significantly increased after repetitive HBO treatments. The absolute alpha power and the peak alpha power insignificantly improved. Total numbers of HBO treatments were not correlated with age, duration of CO exposure, initial level of COHb, or interval to the first HBO treatment. After the completion of repetitive HBO treatments, no patient developed delayed neuropsychiatric sequelae.
  
  
  CONCLUSIONS
  These results suggest that repetitive HBO treatments may prevent the delayed neuropsychiatric sequelae of CO poisoning when applied individually with monitoring of the peak alpha frequency as an indicator of efficacy.
authors.affiliation: Department of Neuropsychiatry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Murata
authors.forename: Michio
authors.initials: M
authors.lastname: Suzuki
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Shigeru
authors.initials: S
authors.lastname: Nohara
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kurachi
mesh_terms: D000328:Adult; D000513:Alpha Rhythm / Q000379:methods; D002249:Carbon Monoxide Poisoning / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D003952:Diagnostic Imaging / Q000145:classification / Q000379:methods; D005260:Female; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009778:Occipital Lobe / Q000473:pathology / Q000503:physiopathology*; D016896:Treatment Outcome