title: New synthetic route for the enantioselective total synthesis of salinosporamide A and biologically active analogues.
abstract: [reaction: see text] A total synthesis of the salinosporamide analogue 3 is described that starts with the novel cyclization 4 --> 5.
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
authors.forename: Leleti Rajender
authors.initials: LR
authors.lastname: Reddy
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Fournier
authors.forename: B V Subba
authors.initials: BV
authors.lastname: Reddy
authors.forename: E J
authors.initials: EJ
authors.lastname: Corey
mesh_terms: D002384:Catalysis; D003500:Cyclization; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D007783:Lactones; D011758:Pyrroles; C117645:omuralide; C475865:marizomib