title: Genome-wide analysis on inbreeding effects on gene expression in Drosophila melanogaster.
abstract: The deleterious consequences of inbreeding, especially in the form of inbreeding depression, are well known. However, little is known about how inbreeding affects genome-wide gene expression. Here, we show that inbreeding changes transcription levels for a number of genes. Gene expression profiles of Drosophila melanogaster lines inbred to F approximately = 0.67 at different rates changed relative to those of noninbred lines, but the rate of inbreeding did not significantly affect gene expression patterns. Genes being differentially expressed with inbreeding are disproportionately involved in metabolism and stress responses, suggesting that inbreeding acts like an environmental stress factor.
authors.affiliation: Aarhus Centre for Environmental Stress Research, Department of Ecology and Genetics, University of Aarhus, Denmark. torsten.nygaard@agrsci.dk
authors.forename: Torsten Nygaard
authors.initials: TN
authors.lastname: Kristensen
authors.forename: Peter
authors.initials: P
authors.lastname: Sørensen
authors.forename: Mogens
authors.initials: M
authors.lastname: Kruhøffer
authors.forename: Kamilla Sofie
authors.initials: KS
authors.lastname: Pedersen
authors.forename: Volker
authors.initials: V
authors.lastname: Loeschcke
mesh_terms: D000818:Animals; D016000:Cluster Analysis; D015536:Down-Regulation / Q000235:genetics; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D020869:Gene Expression Profiling; D017344:Genes, Insect / Q000235:genetics; D016678:Genome; D007178:Inbreeding; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015854:Up-Regulation / Q000235:genetics