title: Preparation of adsorbents for the removal of endotoxin.
abstract: By using the agar beads as the support, L-lysine as the ligand, three kinds of absorbents with different spacers for removal of endotoxin were prepared. The adsorption capacity of three adsorbents was compared. Among them, Ag3, with L-lysine ligand and hexamethylendiamine as the spacer, was the best in adsorption capacity and was selected for hemoperfusion on rabbits. The results showed the level of endotoxin in endotoxemia rabbit after hemoperfusion was near normal level. The clearance percentage of endotoxin was 73.6%
authors.affiliation: The State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Institute of Polymer Chemistry, Nankai University, Tianjin, China.
authors.forename: Guanghui
authors.initials: G
authors.lastname: Hou
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.forename: Huiyan
authors.initials: H
authors.lastname: Wang
authors.forename: Guoqi
authors.initials: G
authors.lastname: Fu
authors.forename: Zhi
authors.initials: Z
authors.lastname: Yuan
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Lanju
authors.initials: L
authors.lastname: Sun
authors.forename: Jie
authors.initials: J
authors.lastname: Fang
authors.forename: Donghua
authors.initials: D
authors.lastname: Li
authors.forename: Qi
authors.initials: Q
authors.lastname: Qiu
mesh_terms: D000327:Adsorption; D000818:Animals; D019446:Endotoxemia / Q000628:therapy*; D004731:Endotoxins / Q000302:isolation & purification*; D006464:Hemoperfusion / Q000379:methods*; D008024:Ligands; D008239:Lysine; D011817:Rabbits
chemical_list: D004731:Endotoxins; D008024:Ligands; D008239:Lysine