title: A critical function for type I interferons in cancer immunoediting.
abstract: 'Cancer immunoediting' is a process wherein the immune system protects hosts against tumor development and facilitates outgrowth of tumors with reduced immunogenicity. Although interferon-gamma (IFN-gamma) is known to be involved in this process, the involvement of type I interferons (IFN-alpha/beta) has not been elucidated. We now show that, like IFN-gamma, endogenously produced IFN-alpha/beta was required for the prevention of the growth of primary carcinogen-induced and transplantable tumors. Although tumor cells are important IFN-gamma targets, they are not functionally relevant sites of the actions of the type I interferons. Instead, host hematopoietic cells are critical IFN-alpha/beta targets during development of protective antitumor responses. Therefore, type I interferons are important components of the cancer immunoediting process and function in a way that does not completely overlap the functions of IFN-gamma.
authors.affiliation: Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
authors.forename: Gavin P
authors.initials: GP
authors.lastname: Dunn
authors.forename: Allen T
authors.initials: AT
authors.lastname: Bruce
authors.forename: Kathleen C F
authors.initials: KC
authors.lastname: Sheehan
authors.forename: Vijay
authors.initials: V
authors.lastname: Shankaran
authors.forename: Ravindra
authors.initials: R
authors.lastname: Uppaluri
authors.forename: Jack D
authors.initials: JD
authors.lastname: Bui
authors.forename: Mark S
authors.initials: MS
authors.lastname: Diamond
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Koebel
authors.forename: Cora
authors.initials: C
authors.lastname: Arthur
authors.forename: J Michael
authors.initials: JM
authors.lastname: White
authors.forename: Robert D
authors.initials: RD
authors.lastname: Schreiber
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000276:immunology; D006410:Hematopoiesis / Q000276:immunology; D016898:Interferon-alpha / Q000276:immunology*; D008565:Membrane Proteins / Q000276:immunology*; D008748:Methylcholanthrene; D051379:Mice; D018345:Mice, Knockout; D009374:Neoplasms, Experimental / Q000276:immunology*; D011828:Radiation Chimera; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon / Q000276:immunology*; D012509:Sarcoma / Q000276:immunology*; D019139:Tumor Escape / Q000276:immunology*
chemical_list: D004268:DNA-Binding Proteins; D016898:Interferon-alpha; D008565:Membrane Proteins; C499308:Rag2 protein, mouse; D017471:Receptors, Interferon; C064655:V(D)J recombination activating protein 2; D053633:Receptor, Interferon alpha-beta; D008748:Methylcholanthrene