[Regulation of E-cadherin by the Akt protein kinase B].
E-cadherin is a cell adhesion molecule that is present in most normal epithelial cells. During malignant transformation, the expression of E-cadherin is frequently repressed. This protein is considered as a tumor-suppressor. The oncogenic form of Akt, a serine-threonine kinase, is multifunctionnal. One of its function is to induce the transcriptional repression of E-cadherin. This transcriptional repression induces cellular responses, epithelial cells becoming mesenchymal and invasive. At the molecular level, cells expressing a constitutive active form of Akt express also a transcription factor, Snail, known to repress the expression of E-cadherin.
Grille
Sylvia
S
Developmental Genetics of Melanocytes, UMR 146 CNRS-Institut Curie, Bat. 110, 91405 Orsay Cedex, France.
Bellacosa
Alfonso
A
Larue
Lionel
L
D000818:Animals; D015820:Cadherins / Q000235:genetics / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt; D014746:Vimentin / Q000502:physiology
D015820:Cadherins; D011518:Proto-Oncogene Proteins; D014746:Vimentin; C494918:AKT1 protein, human; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt