High titers of CA-125 may be associated with recurrent ischemic strokes in patients with cancer.
In addition to etiologies common in the general population, strokes in cancer patients may be caused by hypercoagulable states, hyperviscosity, cardiogenic embolism, and neoplastic vessel infiltration. Intravascular mucins were reported in patients with recurrent thromboembolism. The authors report four patients with metastatic cancer, brain infarcts, and other thromboembolic disease with markedly elevated levels of the tumor marker CA-125 and explore possible associations between this mucinous protein and strokes.
Jovin
T G
TG
Department of Neurology, Stroke Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213-2582, USA. jovintg@upmc.edu
Boosupalli
V
V
Zivkovic
S A
SA
Wechsler
L R
LR
Gebel
J M
JM
D000368:Aged; D001778:Blood Coagulation Disorders / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D002545:Brain Ischemia / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D018394:CA-125 Antigen / Q000097:blood*; D002277:Carcinoma / Q000097:blood / Q000150:complications* / Q000378:metabolism; D017809:Fatal Outcome; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009077:Mucins / Q000097:blood* / Q000378:metabolism; D009362:Neoplasm Metastasis / Q000503:physiopathology; D020521:Stroke / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D013923:Thromboembolism / Q000097:blood / Q000209:etiology* / Q000503:physiopathology
D018394:CA-125 Antigen; D005343:Fibrinolytic Agents; D009077:Mucins