Reye's syndrome developing in an infant on treatment of Kawasaki syndrome.
Aspirin is commonly used as an anti-inflammatory therapy for Kawasaki syndrome. Early initiation with high dose aspirin (80 to > 100 mg/kg per day), followed by low-dose therapy at the afebrile stage, has been often used to reduce morbidity and mortality in coronary complications. We report a 10-month-old infant who was diagnosed with Kawasaki syndrome. Sudden onset of poor activity, poor appetite, lethargy, tachycardia, tachypnea, hepatomegaly, increased AST/ALT, coagulopathy and hyperammonemia developed 3 days after the high-dose aspirin therapy. His histopathological and ultrastructural findings from the liver biopsy were compatible with Reye's syndrome. He recovered completely, and there was no recurrence.
Wei
Chih-Ming
CM
Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
Chen
Huey-Ling
HL
Lee
Ping-Ing
PI
Chen
Chong-Ming
CM
Ma
Chun-Yi
CY
Hwu
Wuh-Liang
WL
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications / Q000188:drug therapy*; D012202:Reye Syndrome / Q000209:etiology* / Q000503:physiopathology; D013624:Taiwan
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin