[Assessment of metabolic impairments inducted by atypical antipsychotics among schizophrenic patients].
Conventional and atypical antipsychotics are known to induce weight gain, cause glucose and lipid impairments among schizophrenic patients. These impairments contribute to the intrinsic risk factors linked to the psychiatric pathology (sedentary state, nicotin addiction, diabetes) increasing numbers of cardiovascular complications. We propose to study ponderal modifications and presence of metabolic abnormalities in a population of schizophrenic patients treated by conventional or atypical antipsychotics, depending on the received treatment; 32 patients, whose schizophrenia diagnosis had been previously made, were consecutively included over a 4 months period. They were divided into three groups: patients treated by conventional antipsychotics (n = 6), by atypical antipsychotics (n = 16) or by a combination of both (n = 10); 6 patients (18%) display overweight problems, 4 patients (12.5%) got hypertriglyceridemia and 4 other patients (12.5%) have hypercholesterolemia. No particular drug could be directly targeted, partly because of the restricted size of our sample, but the patients presenting metabolism impairment were treated by atypical antipsychotic. The observance of these abnormalities is reflected in publications and lead to some antipsychotic treatments monitoring rules.
Gauthé
M
M
Service Hospitalo-Universitaire, CH Sainte-Anne, 7, rue Cabanis, 75014 Paris.
Goldberger
C
C
Olié
J P
JP
Lôo
H
H
Gury
C
C
Poirier
M F
MF
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood* / Q000139:chemically induced* / Q000453:epidemiology; D006949:Hyperlipidemias / Q000097:blood* / Q000139:chemically induced* / Q000453:epidemiology; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D009765:Obesity / Q000139:chemically induced* / Q000175:diagnosis* / Q000453:epidemiology; D012307:Risk Factors; D012559:Schizophrenia / Q000188:drug therapy*; D012720:Severity of Illness Index
D014150:Antipsychotic Agents; D002784:Cholesterol