[The place of routine immediate non-invasive ventilation following pulmonary resection in preventing pulmonary complications in patients with COPD (POPVNI Trial)].
BACKGROUND
Respiratory complications are common following pulmonary resection and cause a significant mortality. The use of non-invasive ventilation (NIV) in acute respiratory insufficiency (ARI) is now well recognised. The prophylactic use of NIV in the absence of ARI and/or hypercapnia may be equally justified for the physiological benefits expected in the post-operative period following pulmonary surgery. The aim of our study therefore is to evaluate the effectiveness of NIV in the prevention of pulmonary complications in the immediate post-operative care of patients with moderate and severe COPD.


METHODS
It will be a multicentre, prospective, randomised, parallel, open ended study of patients with moderate and severe COPD admitted to hospital for pulmonary resection.


RESULTS
To determine whether the setting up of NIV immediately post-operatively reduces the incidence of acute respiratory events (acute respiratory insufficiency) and to identify any sub-groups who receive greater benefit from NIV. This study should establish the place of NIV in the immediate post operative care following pulmonary resection.
Lorut
C
C
Service de pneumologie et reanimation, Hôpital Hôtel Dieu, Paris, France. christine.lorut@htd.ap-hop-paris.fr
Rabbat
A
A
Chatelier
G
G
Lefevre
A
A
Roche
N
N
Regnard
J F
JF
Huchon
G
G
D000328:Adult; D006801:Humans; D008171:Lung Diseases / Q000209:etiology / Q000517:prevention & control*; D011013:Pneumonectomy / Q000009:adverse effects*; D011182:Postoperative Care; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000628:therapy*; D012121:Respiration, Artificial; D012720:Severity of Illness Index; D013997:Time Factors