[Comparative study between cystoscopy, urinary cytology, NMP-22 and a new method, bladder chek, in the follow-up of superficial bladder cell carcinoma].
OBJECTIVE
The goal of this work tries to evaluate the utility of the qualitative determination of NMP-22 in the evaluation of the superficial bladder carcinoma in asymptomatic patients, comparing it with its quantitative determination, the cytology and the cystoscopy.


METHODS
A simple of urine just voided was taken in 88 asymptomatic patient follow-up for superficial bladder cell carcinoma. This dose was distributed in 3 parts, for performed cytology, for determination of NMP-22, and 4 drops of the third part are added to device bladder chek. Later, we performed cystoscopy and transurethral resection in patients with a suspicion of bladder cancer.


RESULTS
26 patients had tumor relapse and 62 patients were free of disease. The sensitivity for the bladder chek was of 28%, 34.62% for NMP-22, 34.62% for cytology and 100% for cystoscopy. The specificity was of 93.55%, 80.33%, 87.10% and 87.10% respectively. The sensitivity by degree was 25 in G1, 28.57 in G2 and 50 in G3 for Bladder chek; 29.41, 42.86 and 50 for NMP-22; 23.53, 71.43 and 0 for cytology. The sensitivity by stages was 27.7 in Ta-1 and 50 in T2 for Bladder chek; 34.78 and 50 for NMP-22; 39.13 and 0 for the cytology.


CONCLUSIONS
The low sensitivity of bladder chek invalidates it like alternative method to the cystoscopy in the follow-up of the superficial asymptomatic bladder cell carcinoma.
Aguilera Tubet
C
C
Servicio de Urologia, Hospital Universitario Marqués de Valdecilla, Santander.
Gutiérrez Baños
J L
JL
Antolín Juárez
F
F
Rebollo Rodrigo
Maria H
MH
Portillo Martín
J A
JA
Ruiz Izquierdo
F
F
Ballestero Diego
R
R
Martín García
B
B
D002295:Carcinoma, Transitional Cell / Q000175:diagnosis*; D003558:Cystoscopy; D005260:Female; D006801:Humans; D007159:Immunologic Tests; D008297:Male; D009687:Nuclear Proteins / Q000032:analysis*; D012680:Sensitivity and Specificity; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis*; D014556:Urine / Q000166:cytology*
D009687:Nuclear Proteins; C100379:nuclear matrix protein 22