title: Histone modifications: from genome-wide maps to functional insights.
abstract: A large number of histone modifications has been implicated in the regulation of gene expression. Together, these modifications have the potential to form a complex combinatorial regulatory code. Genome-wide mapping approaches provide new opportunities to decipher this code, but they may suffer from systematic biases. Integration of datasets and improved technologies will provide the way forward.
authors.affiliation: Netherlands Cancer Institute, Plesmanlaan 121,1066 CX Amsterdam, The Netherlands.
authors.forename: Fred
authors.initials: F
authors.lastname: van Leeuwen
authors.forename: Bas
authors.initials: B
authors.lastname: van Steensel
mesh_terms: D000107:Acetylation; D000818:Animals; D005786:Gene Expression Regulation; D016678:Genome / Q000235:genetics*; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009707:Nucleosomes / Q000235:genetics / Q000378:metabolism
chemical_list: D006657:Histones; D009707:Nucleosomes