title: Changes of gastrointestinal myoelectric activity and bile acid pool size after cholecystectomy in guinea pigs.
abstract: OBJECTIVE
  To investigate the bile acid pool size after cholecystectomy whether or not correlated to the gastrointestinal migrating myoelectric complex (MMC) in guinea pigs.
  
  
  METHODS
  Gallbladder motilities were assessed before cholecystectomy. Furthermore, we continuously monitored interdigestive gastrointestinal motilities using bipolar electrodes in conscious guinea pigs before and after surgery at 4 wk in standard diet group and high cholesterol diet (cholesterol gallstone) group. Total bile acid pool sizes were measured by isotope dilution method at meantime.
  
  
  RESULTS
  After cholecystectomy, there were parallel falls in duration of phase I, II, III and MMC cycle duration but increase in amplitude in the guinea pigs with normal gallbladder function, and in the guinea pigs with cholesterol stones. However, There were not significantly differences. On the other hand, the bile acid pool was definitely small in the GS guinea pigs compared to normal guinea pigs and became slightly smaller after cholecystectomy. Similarly, bile acid in gallbladder bile, fecal bile acid was slightly increased in GS guinea pigs after cholecystectomy, to the same degree as normal. These differences, however, were not significant.
  
  
  CONCLUSIONS
  It is concluded that in the guinea pigs with normal gallbladder function, and in the guinea pigs with cholesterol stones: (1) Cholecystectomy produce a similar but less marked trend in bile acid pool; and (2) MMC are linked to enterohepatic circulation of bile acids, rather than surgery, which is consistent with changes of the bile acid pool size. As a result, gastrointestinal dyskinesia is not involved in occurrence of postcholecystectomy syndrome.
authors.affiliation: Department of Gastroenterology, Second Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Dong
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Liu
authors.forename: Bi-Xia
authors.initials: BX
authors.lastname: Chang
authors.forename: Qian
authors.initials: Q
authors.lastname: He
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D002763:Cholecystectomy; D004576:Electromyography; D005260:Female; D005704:Gallbladder / Q000502:physiology; D042882:Gallstones / Q000378:metabolism / Q000503:physiopathology* / Q000601:surgery*; D006168:Guinea Pigs; D016065:Myoelectric Complex, Migrating / Q000502:physiology*; D011183:Postoperative Complications / Q000209:etiology / Q000503:physiopathology
chemical_list: D001647:Bile Acids and Salts