title: Time-resolved resonance Raman observation of the 2-fluorenylnitrenium ion reaction with guanosine to form a C8 intermediate.
abstract: Time-resolved resonance Raman spectroscopy was used to directly observe the reaction of the 2-fluorenylnitrenium ion with guanosine to produce a C8 intermediate species. Comparison of the Raman spectra with results of density functional theory calculations indicates the C8 intermediate forms two C=N conjugated bonds in ring 1 of the guanosine moiety.
authors.affiliation: Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong.
authors.forename: Pik Ying
authors.initials: PY
authors.lastname: Chan
authors.forename: Wai Ming
authors.initials: WM
authors.lastname: Kwok
authors.forename: Sze Kui
authors.initials: SK
authors.lastname: Lam
authors.forename: Pauline
authors.initials: P
authors.lastname: Chiu
authors.forename: David Lee
authors.initials: DL
authors.lastname: Phillips
mesh_terms: D015073:2-Acetylaminofluorene / Q000737:chemistry*; D002273:Carcinogens / Q000737:chemistry; D018736:DNA Adducts / Q000737:chemistry; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives*; D006151:Guanosine / Q000737:chemistry*; D007477:Ions; D013059:Spectrum Analysis, Raman
chemical_list: D002273:Carcinogens; D018736:DNA Adducts; D007477:Ions; D006151:Guanosine; D015073:2-Acetylaminofluorene; D003849:Deoxyguanosine