Polycystic ovaries and ovarian hyperstimulation syndrome: a systematic review*.
OBJECTIVE
To assess and quantify the relationship between polycystic ovaries (PCOs) and ovarian hyperstimulation syndrome (OHSS).


METHODS
Published studies, any language, identified through MEDLINE, EMBASE, BIOSIS, Web of Science, and bibliographies. Studies were selected if exposure (ultrasound findings of PCO before treatment) and outcome (OHSS) could be abstracted to two-by-two tables.


RESULTS
Ten studies, meeting inclusion and exclusion criteria, were analyzed. When PCO were present, the combined odds ratio for OHSS was 6.8 (95% confidence interval 4.9-9.6).


CONCLUSIONS
There is a significant and consistent relationship between PCO and OHSS. When PCO are present before treatment with assisted reproduction, deliberate policies to moderate treatment appear justified.
Tummon
Ian
I
Mayo Clinic, Rochester, Minnesota, USA. tummon.ian@mayo.edu
Gavrilova-Jordan
Larisa
L
Allemand
Michael C
MC
Session
Donna
D
D005260:Female; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D012307:Risk Factors