title: A homochiral porous metal-organic framework for highly enantioselective heterogeneous asymmetric catalysis.
abstract: A homochiral porous noninterpenetrating metal-organic framework (MOF), 1, was constructed by linking infinite 1D [Cd(mu-Cl)2]n zigzag chains with axially chiral bipyridine bridging ligands containing orthogonal secondary functional groups. The secondary chiral dihydroxy groups accessible via the large open channels in 1 were utilized to generate a heterogeneous asymmetric catalyst for the addition of diethyzinc to aromatic aldehydes to afford chiral secondary alcohols at up to 93% enantiomeric excess (ee). Control experiments with dendritic aromatic aldehydes of different sizes indicate that the heterogeneous asymmetric catalyst derived from 1 is both highly active and enantioselective as a result of the creation of readily accessible, uniform active catalyst sites inside the porous MOF.
authors.affiliation: Department of Chemistry, CB#3290, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
authors.forename: Chuan-De
authors.initials: CD
authors.lastname: Wu
authors.forename: Aiguo
authors.initials: A
authors.lastname: Hu
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Wenbin
authors.initials: W
authors.lastname: Lin
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D016062:Porosity; D013237:Stereoisomerism; D014025:Titanium / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D008024:Ligands; D009942:Organometallic Compounds; D014025:Titanium