title: Long-term outcomes using vascular grafts sealed with fragmented autologous adipose tissue for aortoiliac occlusive disease.
abstract: The aim of this study was to test the safety and efficacy of fragmented autologous adipose tissue (FAT) grafts for revascularization in aortoiliac occlusive disease. Twenty-seven patients with atherosclerotic aortoiliac occlusive disease underwent surgical treatment using FAT grafts. A piece of adipose connective tissue was obtained from the operative wound, cut into small pieces, and pressed into the wall of a fabric vascular prosthesis. Cumulative primary patency rates were 92% at 1 year, 92% at 3 years, and 86% at 6 years. Cumulative secondary patency rates were 96%, 96%, and 90% for the same intervals. In this clinical study, the FAT grafts demonstrated good long-term patency rates and no particular problems. This is the first clinical report of long-term outcomes using FAT grafts for aortofemoral or aortoiliac bypasses. FAT grafts are thus safe for revascularization in aortoiliac occlusive disease.
authors.affiliation: Department of Cardiovascular Surgery, Saiseikai Yokohama Nanbu Hospital, 3-2-10 Kounandai, Kounan-ku, Yokohama, 234-8503, Japan. pxc02607@nifty.ne.jp
authors.forename: Ichiya
authors.initials: I
authors.lastname: Yamazaki
authors.forename: Norihisa
authors.initials: N
authors.lastname: Karube
authors.forename: Tamitaro
authors.initials: T
authors.lastname: Soma
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Noishiki
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ichikawa
mesh_terms: D000273:Adipose Tissue; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001018:Aortic Diseases / Q000601:surgery*; D001157:Arterial Occlusive Diseases / Q000601:surgery*; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation; D005260:Female; D006801:Humans; D007083:Iliac Artery; D015993:Life Tables; D008297:Male; D008875:Middle Aged; D023822:Tissue Engineering; D016896:Treatment Outcome; D014654:Vascular Patency