title: Enhanced peptide beta-sheet affinity by metal to ligand coordination.
abstract: A histidine-coordinating metal complex substituted with methoxypyrrole amino acids (MOPAS) as a peptide beta-sheet binder shows high affinity for a H(2)N-His-Leu-Leu-Val-Phe-OMe pentapeptide in DMSO solution. Within the complex, a beta-sheet conformation is induced into the pentapeptide by weak intra-assembly interactions with the MOPAS units.
authors.affiliation: Institut für Organische Chemie, Universität Regensburg, Universitätsstrasse 31, D-93040 Regensburg, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Kruppa
authors.forename: Christoph
authors.initials: C
authors.lastname: Bonauer
authors.forename: Veronika
authors.initials: V
authors.lastname: Michlová
authors.forename: Burkhard
authors.initials: B
authors.lastname: König
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry*; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; C502154:H(2)N-His-Leu-Leu-Val-Phe-OMe; D008024:Ligands; D009842:Oligopeptides