Gabapentin-induced myopathy in 2 patients on short daily hemodialysis.
Gabapentin is an antiepileptic medication that also has been used for restless legs syndrome. The mechanism of action is unknown. The most commonly reported adverse effects of this medication include somnolence, dizziness, ataxia, fatigue, nystagmus, and tremor. Myalgia has been reported in 2% of gabapentin users compared with 1.9% of patients in placebo-controlled add-on trials. Two patients on short daily hemodialysis therapy developed neuromuscular symptoms and an elevation in creatine kinase levels after starting gabapentin therapy. To our knowledge, this is the first case report of an increase in creatine kinase level after the administration of gabapentin.
Lipson
Jennifer
J
Ottawa Hospital, Department of Medicine, Kidney Research Centre, University of Ottawa, Ontario, Canada.
Lavoie
Susan
S
Zimmerman
Deborah
D
D000328:Adult; D000588:Amines / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D000927:Anticonvulsants / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D000069059:Atorvastatin; D015220:Calcium Channels / Q000187:drug effects; D015897:Comorbidity; D003509:Cyclohexanecarboxylic Acids / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D000077206:Gabapentin; D005921:Glomerulonephritis / Q000150:complications / Q000628:therapy; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications / Q000601:surgery; D006538:Heptanoic Acids / Q000009:adverse effects; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects; D007676:Kidney Failure, Chronic / Q000150:complications / Q000209:etiology / Q000628:therapy; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009468:Neuromuscular Diseases / Q000139:chemically induced*; D010530:Peritoneal Dialysis; D005082:Physical Exertion; D011183:Postoperative Complications / Q000139:chemically induced; D011758:Pyrroles / Q000009:adverse effects; D012008:Recurrence; D006435:Renal Dialysis; D012148:Restless Legs Syndrome / Q000188:drug therapy* / Q000209:etiology; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use
D000588:Amines; D000927:Anticonvulsants; D015220:Calcium Channels; D003509:Cyclohexanecarboxylic Acids; D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D000069059:Atorvastatin