title: [The AREA IN-CHF trial (antiremodeling effect of aldosterone receptors blockade with canrenone in mild chronic heart failure): rationale and design].
abstract: The RALES study has shown that spironolactone reduces the risk of morbidity and mortality both from progressive heart failure and sudden death in patients with NYHA class III or IV heart failure. This favorable effect was clearly independent of a diuretic effect. EPHESUS extended these results to eplerenone in patients with acute myocardial infarction complicated by left ventricular dysfunction and signs of heart failure. Antialdosterone drugs may be effective because they oppose the effects of aldosterone to sodium retention, loss of magnesium and potassium, sympathetic activation, baroreceptor function and vascular compliance. Antialdosterone treatment may also antagonize the effect of aldosterone in promoting cardiac fibrosis. In a RALES substudy baseline serum PIIINP, a marker of extracellular matrix turnover, showed an independent negative correlation with survival and chronic heart failure hospitalizations in the placebo group. Therefore it seems interesting to evaluate the effect of canrenone, an aldosterone receptor blocker, on the progression of left ventricular dysfunction in patients with mild heart failure assuming standard therapy.
authors.affiliation: U.O.C. di Cardiologia, Azienda Ospedaliera San Giovanni-Addolorata, Roma. gcacciatore@iol.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cacciatore
authors.forename: Alessandro
authors.initials: A
authors.lastname: Boccanelli
authors.forename: Gian Francesco
authors.initials: GF
authors.lastname: Mureddu
authors.forename: Aldo Pietro
authors.initials: AP
authors.lastname: Maggioni
authors.forename: Roberto
authors.initials: R
authors.lastname: Latini
authors.forename: Serge
authors.initials: S
authors.lastname: Masson
authors.forename: Giovanni
authors.initials: G
authors.lastname: de Simone
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002986:Clinical Trials as Topic / Q000379:methods; D006333:Heart Failure / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D000451:Mineralocorticoid Receptor Antagonists; D020257:Ventricular Remodeling / Q000187:drug effects*
chemical_list: D000451:Mineralocorticoid Receptor Antagonists