HLA-DRB1 and anti-cyclic citrullinated peptide antibody production in rheumatoid arthritis.
Anti-cyclic citrullinated peptide antibodies (anti-CCP) are a new diagnostic marker for rheumatoid arthritis (RA), which shows a specificity of 97% and a sensitivity of 81% in the second generation assay. About 61% of RA patients express HLA-DRB1*0401. In a cohort of patients with RA we investigated whether the expression of anti-CCP correlates with the carriage of certain genes on the HLA-DRB1 locus. Our data reveal a highly significant association between anti-CCP and HLA-DR4, and a weaker but still significant association with HLA-DR1. HLA-DRB1*0401 is not a prerequisite for anti-CCP production, but if HLA-DRB1*0401 was present, 90% of our RA patients were anti-CCP positive.
Senkpiehl
Ilka
I
Department of Immunology, UKS-H Campus Kiel, Germany.
Marget
Matthias
M
Wedler
Martina
M
Jenisch
Stefan
S
Georgi
Joachim
J
Kabelitz
Dietrich
D
Steinmann
Jorg
J
D001172:Arthritis, Rheumatoid / Q000097:blood / Q000235:genetics / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics* / Q000276:immunology; D015804:HLA-DR4 Antigen / Q000235:genetics / Q000276:immunology; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D010456:Peptides, Cyclic / Q000097:blood / Q000276:immunology*
D001323:Autoantibodies; D015415:Biomarkers; D006684:HLA-DR Antigens; D015804:HLA-DR4 Antigen; D059811:HLA-DRB1 Chains; C553505:HLA-DRB1*04:01 antigen; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide