title: [Preliminary results of radiosurgery for uveal melanoma].
abstract: OBJECTIVE
  To evaluate the clinical value of stereotactic radiosurgery (SRS) for uveal melanoma.
  
  
  METHODS
  From Jan, 1996 to March, 2004, 16 patients with uveal melanoma were treated with SRS, two by one session (35 Gy, 25 Gy) and fourteen by fractionated SRS (30-55 Gy/2-4F/4-16D). The follow-up period ranged from 3 to 100 months (median: 66 months).
  
  
  RESULTS
  All 16 patients were still alive though all were blind in the diseased eye during recent follow-up. Local control rate was 93.4%, 5-year survival rate of 13 patients who have been followed for more than 5 years, was 100% (13/13). However, 7 patients received eyeball enucleation due to corneal ulcer (n = 2), suspicion for uncontrolled tumor (n = 2) and secondary glaucoma (n = 3). One patient developed distant metastasis, though still alive.
  
  
  CONCLUSIONS
  Fractionated radiosurgery is safe and effective for uveal melanoma. It is indicated for lesions of limited size (longest diameter < 20 mm, depth < 15 mm) located in the posterior pole or behind the equator at the back of the eyeball.
authors.affiliation: Department of Radiation Oncology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China.
authors.forename: Jian-ping
authors.initials: JP
authors.lastname: Xiao
authors.forename: Guo-zhen
authors.initials: GZ
authors.lastname: Xu
authors.forename: Yan-jun
authors.initials: YJ
authors.lastname: Miao
authors.forename: Wen-bin
authors.initials: WB
authors.lastname: Wei
authors.forename: Shi-min
authors.initials: SM
authors.lastname: Hu
authors.forename: Xin
authors.initials: X
authors.lastname: Tang
authors.forename: Jing-zhao
authors.initials: JZ
authors.lastname: Wang
authors.forename: Guang-lu
authors.initials: GL
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D015353:Eye Enucleation / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000601:surgery*; D008875:Middle Aged; D016634:Radiosurgery; D013238:Stereotaxic Techniques; D014604:Uveal Neoplasms / Q000601:surgery*