Lipoxin agonists: turn right! to path of resolving neutrophil.
An impressive array of cellular and molecular adaptive responses achieves homeostasis. The inflammatory reaction is an adaptive response triggered by an insult to culminate into the overt cardinal signs of inflammation, eventually leading to resolution and returning the organism back to its original centered state. This article focuses on some aspects of the lipoxin A4 signaling pathway during the resolution phase, to better understand molecular mechanisms by which a neutrophil directs an inflammatory reaction to switch off and resume homeostasis. Defining the resolution state of a neutrophil at the molecular level will aid in treatments of diseases that are associated with an exaggerated and uncontrolled inflammation.
Devchand
Pallavi R
PR
Center for Excellence in Vascular Biology, Cardiovascular Division, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA. pdevchand@rics.bwh.harvard.edu
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology*; D044045:Lipoxins / Q000819:agonists* / Q000096:biosynthesis; D051379:Mice; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D015398:Signal Transduction; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D018836:Inflammation Mediators; D044045:Lipoxins; C040527:lipoxin A4; D001241:Aspirin