Histological assessment of ovaries and uterus of rats subjected to nandrolone decanoate treatment.
This study aimed to analyze the effects of nandrolone decanoate on the ovaries and uterus of adult females rats. This drug was administered intraperitoneally, at one, two and three doses of 3 mg nandrolone decanoate/kg of body weight, respectively, in the first, second and third week of treatment. The females of the control group received a physiological solution. The rats treated with nandrolone decanoate showed estral acyclicity and there was destruction of follicular units and an absence of corpus luteum in the ovaries. In the uterus, the drug promoted morphological alterations, characterized by vacuolated epithelium and endometrial stroma fibrosis. Ovary, uterus and pituitary weights were not affected by the steroid treatment. Nandrolone decanoate affects the sexual cycle and promotes histological alterations in the ovaries and uterus of adult female rats.
Gerez
Juliana Rubira
JR
Department of Biological Sciences, Faculty of Sciences and Letters, UNESP, Assis, Brazil.
Frei
Fernando
F
Camargo
Isabel Cristina Cherici
IC
D045930:Anabolic Agents / Q000009:adverse effects*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003338:Corpus Luteum / Q000187:drug effects; D030762:Estrous Cycle / Q000187:drug effects; D005260:Female; D008099:Liver / Q000033:anatomy & histology; D009277:Nandrolone / Q000009:adverse effects / Q000031:analogs & derivatives*; D000077603:Nandrolone Decanoate; D009929:Organ Size / Q000187:drug effects; D006080:Ovarian Follicle / Q000187:drug effects; D010053:Ovary / Q000033:anatomy & histology / Q000187:drug effects*; D010902:Pituitary Gland / Q000033:anatomy & histology; D051381:Rats; D017208:Rats, Wistar; D014599:Uterus / Q000033:anatomy & histology / Q000187:drug effects*
D045930:Anabolic Agents; D009277:Nandrolone; D000077603:Nandrolone Decanoate