title: [Targeted adhesion of platelet receptor-specific microbubble agent to thrombus in vitro].
abstract: OBJECTIVE
  To examine the thrombus-targeting effect of platelet receptor-specific lipid microbubbles.
  
  
  METHODS
  The targeted microbubbles were prepared by coupling Arg-Gly-Asp-Ser (RGDS) with the lipid microbubbles, which were added to the microthrombus generated by platelet aggregation. The effects of the targeted microbubbles on the ultrasonic signal was observed in an artificial thrombus model.
  
  
  RESULTS
  The targeted microbubbles were adhesive to the microthrombus, while the non-targeted microbubbles did not possess this property. The ultrasonic signal of the thrombus border was enhanced significantly after the addition of the targeted microbubbles.
  
  
  CONCLUSIONS
  Platelet receptor-specific microbubbles possess significant adhesive property to the thrombus and can improve signal-to-noise ratio of the thrombus, suggesting the potential value of the targeted microbubbles for clinical application in the diagnosis and treatment of thrombus.
authors.affiliation: Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Wen-chao
authors.initials: WC
authors.lastname: Ou
authors.forename: Jian-cheng
authors.initials: JC
authors.lastname: Xiu
authors.forename: Jin-guo
authors.initials: JG
authors.lastname: Xie
authors.forename: Dao-gang
authors.initials: DG
authors.lastname: Zha
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.forename: Rui
authors.initials: R
authors.lastname: Hao
authors.forename: Jian-ping
authors.initials: JP
authors.lastname: Bin
authors.forename: Yi-Li
authors.initials: YL
authors.lastname: Liu
mesh_terms: D002448:Cell Adhesion; D016503:Drug Delivery Systems; D006801:Humans; D045423:Microbubbles; D009842:Oligopeptides; D010974:Platelet Aggregation / Q000187:drug effects*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000378:metabolism*; D013927:Thrombosis / Q000000981:diagnostic imaging*; D014463:Ultrasonography
chemical_list: D009842:Oligopeptides; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; C046617:arginyl-glycyl-aspartyl-serine