Cervimycin A-D: a polyketide glycoside complex from a cave bacterium can defeat vancomycin resistance.
Cervimycins A-D are novel polyketide glycosides with significant activity against multi-drug-resistant staphylococci and vancomycin-resistant enterococci. They are produced by a strain of Streptomyces tendae, isolated from an ancient cave. The structures of the cervimycins were determined by performing extensive NMR and chemical degradation studies. All cervimycins have a common tetracyclic polyketide core that is substituted with unusual di- and tetrasaccharide chains, composed exclusively of trideoxysugars; however, they differ in the acetyl and carbamoyl ring substituent and in the highly unusual terminal methylmalonyl and dimethylmalonyl residues.
Herold
Kerstin
K
Leibniz Institute for Natural Products Research and Infection Biology, HKI, Beutenbergstrasse 11a, 07745 Jena, Germany.
Gollmick
Friedrich A
FA
Groth
Ingrid
I
Roth
Martin
M
Menzel
Klaus-Dieter
KD
Möllmann
Ute
U
Gräfe
Udo
U
Hertweck
Christian
C
D001419:Bacteria / Q000737:chemistry* / Q000145:classification / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D020713:Vancomycin Resistance / Q000187:drug effects*
D006027:Glycosides