title: Essential tremor associated with focal nonnigral Lewy bodies: a clinicopathologic study.
abstract: BACKGROUND
  Essential tremor is one of the most common neurological diseases. Its links with Parkinson disease (PD) are often debated. There have been few published postmortem studies.
  
  
  OBJECTIVE
  To study our first case of essential tremor through the recently established Essential Tremor Centralized Brain Repository.
  
  
  METHODS
  Report of a case of a patient with a diagnosis of severe essential tremor for 46 years who exhibited no signs of parkinsonism.
  
  
  RESULTS
  On postmortem examination, gross brain sections showed no abnormalities. Results of microscopic examination of hematoxylin-eosin-stained sections revealed that the locus coeruleus contained multiple Lewy bodies (LBs), although none were found in the substantia nigra, dorsal vagal nuclei, thalamus, substantia innominata, inferior olivary nucleus, or cerebellum. Immunochemical staining using antibodies directed against alpha-synuclein confirmed the presence of many LBs in the locus ceruleus and showed rare LBs in the substantia innominata and dorsal vagal nuclei. There were no LBs in the substantia nigra.
  
  
  CONCLUSIONS
  Our patient had a very focal presence of LBs in the locus ceruleus, an anatomically restricted form of LB disease. This study provides support for the link between essential tremor and LB disease and raises the question as to what proportion of patients with essential tremor might have unusual forms of LB disease.
authors.affiliation: Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA. EDL2@columbia.edu
authors.forename: Elan D
authors.initials: ED
authors.lastname: Louis
authors.forename: Lawrence S
authors.initials: LS
authors.lastname: Honig
authors.forename: Jean Paul G
authors.initials: JP
authors.lastname: Vonsattel
authors.forename: Demetrius M
authors.initials: DM
authors.lastname: Maraganore
authors.forename: Sarah
authors.initials: S
authors.lastname: Borden
authors.forename: Carol B
authors.initials: CB
authors.lastname: Moskowitz
mesh_terms: D000368:Aged; D020329:Essential Tremor / Q000473:pathology*; D005260:Female; D006801:Humans; D016631:Lewy Bodies / Q000737:chemistry / Q000473:pathology*; D020961:Lewy Body Disease / Q000473:pathology*; D013378:Substantia Nigra / Q000737:chemistry / Q000473:pathology