title: [Neurolymphomatosis, a case report].
abstract: Neurolymphomatosis (NL) is characterized by lymphomatous infiltration of the peripheral nervous system. We report a case of neurolymphomatosis (NL) which was confirmed by sural nerve biopsy. Sural nerve specimen from a 49-year-old female patient with weakness of limbs was examined with routine histochemical and immunohistochemistry staining, in which the first antibodies against CD3, CD20, CD45, CD45RO and CD68 were used. Numerous T-lymphoma cells invaded in the adipose tissue of epineurium of sural nerve. The nerve biopsy showed marked axonal degeneration of myelinated fibers. The clinical and histopathologic findings confirmed the diagnosis of neurolymphomatosis.
authors.affiliation: Department of Neurology, Peking University First Hospital, Beijing 100034, China.
authors.forename: Hong-yan
authors.initials: HY
authors.lastname: Bi
authors.forename: Jia
authors.initials: J
authors.lastname: Na
authors.forename: Gui-ming
authors.initials: GM
authors.lastname: Zang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Yun
authors.initials: Y
authors.lastname: Yuan
mesh_terms: D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D008875:Middle Aged; D010524:Peripheral Nervous System Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology