Residues of the lampricides 3-trifluoromethyl-4-nitrophenol and niclosamide in muscle tissue of rainbow trout.
Rainbow trout (Oncorhyncus mykiss) were exposed to the (14)C-labeled lampricide 3-trifluoromethyl-4-nitrophenol (TFM) (2.1 mg/L) or niclosamide (0.055 mg/L) in an aerated static water bath for 24 h. Fish were sacrificed immediately after exposure. Subsamples of skin-on muscle tissue were analyzed for residues of the lampricides. The primary residues in muscle tissue from fish exposed to TFM were parent TFM (1.08 +/- 0.82 nmol/g) and TFM-glucuronide (0.44 +/- 0.24 nmol/g). Muscle tissue from fish exposed to niclosamide contained niclosamide (1.42 +/- 0.51 nmol/g), niclosamide-glucuronide (0.0644 +/- 0.0276 nmol/g), and a metabolite not previously reported, niclosamide sulfate ester (1.12 +/- 0.33 nmol/g).
Hubert
Terrance D
TD
Biological Resources Division, Upper Midwest Environmental Sciences Center, US Geological Survey, La Crosse, Wisconsin 54603, USA. thubert@usgs.gov
Bernardy
Jeffry A
JA
Vue
Chue
C
Dawson
Verdel K
VK
Boogaard
Michael A
MA
Schreier
Theresa M
TM
Gingerich
William H
WH
D000818:Animals; D007798:Lampreys; D009132:Muscles / Q000737:chemistry*; D009534:Niclosamide / Q000032:analysis*; D009596:Nitrophenols / Q000032:analysis*; D017686:Oncorhynchus mykiss; D010573:Pesticide Residues / Q000032:analysis*
D009596:Nitrophenols; D010573:Pesticide Residues; D009534:Niclosamide; C003687:3-trifluoromethyl-4-nitrophenol