Low intracerebroventricular doses of cholinotoxin AF64A do not affect the morphology of gonadotropin hormone-releasing hormone (GnRH)-immunoreactive fibers in the rat septum.
Ethylcholine aziridinium (AF64A) induces cholinergic lesion in animal models of AD. Although higher concentrations of AF64A are known to induce nonspecific, cholinergic, and non-cholinergic lesions, low concentrations are believed to be selectively cholinotoxic. However, morphological evidence of this phenomenon has not been demonstrated yet. The present study demonstrates that while AF64A damaged septal cholinergic fibers, periventricular GnRH-immunoreactive fibers remained intact, confirming the highly selective cholinotoxicity of AF64A at appropriate concentrations.
Semeniken
K
K
Laboratory of Neuroendocrine Organization (NEO), Lake Erie College of Osteopathic Medicine, Erie, PA 16509-1025, USA.
Hanin
I
I
Dudas
B
B
D000818:Animals; D001388:Aziridines / Q000494:pharmacology*; D048429:Cell Size / Q000187:drug effects*; D002794:Choline / Q000031:analogs & derivatives* / Q000494:pharmacology; D007276:Injections, Intraventricular / Q000379:methods; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D012688:Septum Pellucidum / Q000166:cytology / Q000187:drug effects*; D014118:Toxins, Biological / Q000494:pharmacology*
D001388:Aziridines; D014118:Toxins, Biological; C044894:ethylcholine aziridinium; D002794:Choline