title: Generation of landomycin D-producing strain Streptomyces globisporus LD3.
abstract: Rhodinosyl transferase gene lndGT4, governing the conversion of the disaccharide oligoketide ('polyketide') landomycin D into a trisaccharide derivative landomycin E, was deleted in Streptomyces globisporus 1912 genome. Possible resistance mechanisms that protect the resulting landomycin D-producing mutant strain S. globisporus LD3 against the toxic action of landomycins were determined.
authors.affiliation: Department of Genetics and Biotechnology, Ivan Franko National University of Lviv, 79005 Lviv, Ukraine.
authors.forename: B
authors.initials: B
authors.lastname: Ostash
authors.forename: I
authors.initials: I
authors.lastname: Kozarevska
authors.forename: V
authors.initials: V
authors.lastname: Fedorenko
mesh_terms: D000617:Aminoglycosides / Q000096:biosynthesis* / Q000235:genetics / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D017353:Gene Deletion; D005798:Genes, Bacterial; D005816:Genetic Complementation Test; D006031:Glycosylation; D013302:Streptomyces / Q000235:genetics* / Q000378:metabolism*; D014166:Transferases / Q000235:genetics
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C493499:landomycin D; C113593:landomycin E; D014166:Transferases