Recombinant LH in ovarian stimulation.
The advent of recombinant gonadotrophins brought significant changes in fertility therapy. Treatment options with recombinant gonadotrophins add more to knowledge on folliculogenesis and ovarian steroidogenesis. Over a decade, recombinant LH (rLH) has been used for clinical trials, and the amount of peripheral LH that is necessary for optimal follicular growth, oocyte maturation, subsequent embryo development and assisted reproduction outcome during ovulation induction can now be better evaluated. This review evaluates the effect of rLH supplementation on ovarian stimulation and assisted reproduction outcome. The studies conducted with rLH supplementation in ovarian stimulation in different groups of patients and in cases of controlled ovarian stimulation are clearly discussed in this review.
Caglar
Gamze Sinem
GS
Department of Obstetrics and Gynecology, Medical University, Lubeck, Germany.
Asimakopoulos
Byron
B
Nikolettos
Nikos
N
Diedrich
Klaus
K
Al-Hasani
Safaa
S
D005260:Female; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists / Q000037:antagonists & inhibitors; D006062:Gonadotropins / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology; D007986:Luteinizing Hormone / Q000494:pharmacology / Q000627:therapeutic use*; D008423:Maternal Age; D006080:Ovarian Follicle / Q000187:drug effects / Q000502:physiology; D010062:Ovulation Induction / Q000379:methods*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000188:drug therapy; D011247:Pregnancy; D011994:Recombinant Proteins / Q000494:pharmacology / Q000627:therapeutic use; D027724:Reproductive Techniques, Assisted
D006062:Gonadotropins; D011994:Recombinant Proteins; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone