title: Lipiodol alters murine uterine dendritic cell populations: a potential mechanism for the fertility-enhancing effect of lipiodol.
abstract: OBJECTIVE
  To determine whether treatment with lipiodol alters the leukocyte population in the uterus.
  
  
  METHODS
  Randomized controlled animal study.
  
  
  METHODS
  University research laboratory.
  
  
  METHODS
  Sixty female Swiss white mice at proestrous.
  
  
  METHODS
  Infusion of the female reproductive tract with lipiodol versus infusion with saline versus sham treatment.
  
  
  METHODS
  Counts of uterine macrophages, dendritic cells, and total leukocytes assessed by immunohistochemistry.
  
  
  RESULTS
  No statistically significant differences were found in the mean number of total leukocytes or macrophages between the three treatment groups. The mean number of CD205+ dendritic cells showed a statistically significant decrease following lipiodol treatment compared with the sham treatment and saline treatment. The mean number of CD1+ dendritic cells showed a statistically significant increase following lipiodol treatment compared with the sham treatment.
  
  
  CONCLUSIONS
  Intrauterine lipiodol infusion is associated with a change in the uterine dendritic cell populations in mice. This change may alter the uterine immune response to the fetus, leading to improved fertility.
authors.affiliation: Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
authors.forename: Neil Phillip
authors.initials: NP
authors.lastname: Johnson
authors.forename: Santwona
authors.initials: S
authors.lastname: Bhattu
authors.forename: Angela
authors.initials: A
authors.lastname: Wagner
authors.forename: Deborah Adella
authors.initials: DA
authors.lastname: Blake
authors.forename: Lawrence William
authors.initials: LW
authors.lastname: Chamley
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000187:drug effects* / Q000502:physiology*; D005260:Female; D005299:Fertility Agents / Q000494:pharmacology; D007459:Iodized Oil / Q000494:pharmacology*; D051379:Mice; D014599:Uterus / Q000166:cytology / Q000187:drug effects* / Q000502:physiology*
chemical_list: D005299:Fertility Agents; D007459:Iodized Oil