Scoring proteomes with proteotypic peptide probes.
Technologies for genome-wide analyses typically undergo a transition from a discovery phase to a scoring phase. In the discovery phase, the genomic universe is explored and all pertinent data are noted. In the scoring phase, relevant entities are screened to reveal groups of genes that are associated with specific biological processes or conditions. In this article, we propose that the transition from a discovery to a scoring phase is also essential, feasible and imminent for proteomics.
Kuster
Bernhard
B
Department of Analytical Sciences and Informatics, Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany. bernhard.kuster@cellzome.com
Schirle
Markus
M
Mallick
Parag
P
Aebersold
Ruedi
R
D000595:Amino Acid Sequence; D000818:Animals; D016678:Genome; D023281:Genomics; D006801:Humans; D008957:Models, Genetic; D008969:Molecular Sequence Data; D010455:Peptides; D011494:Protein Kinases / Q000737:chemistry / Q000378:metabolism; D011506:Proteins / Q000737:chemistry / Q000235:genetics; D020543:Proteome
D010455:Peptides; D011506:Proteins; D020543:Proteome; D011494:Protein Kinases