title: Osteoblast cell adhesion on a laser modified zirconia based bioceramic.
abstract: Due to their attractive mechanical properties, bioinert zirconia bioceramics are frequently used in the high load-bearing sites such as orthopaedic and dental implants, but they are chemically inert and do not naturally form a direct bond with bone and thus do not provide osseointegration. A CO2 laser was used to modify the surface properties with the aim to achieve osseointegration between bioinert zirconia and bone. The surface characterisation revealed that the surface roughness decreased and solidified microstructure occurred after laser treatment. Higher wettability characteristics generated by the CO2 laser treatment was primarily due to the enhancement of the surface energy, particularly the polar component, determined by microstructural changes. An in vitro test using human fetal osteoblast cells (hFOB) revealed that osteoblast cells adhere better on the laser treated sample than the untreated sample. The change in the wettability characteristics could be the main mechanism governing the osteoblast cell adhesion on the YPSZ.
authors.affiliation: Wolfson School of Mechanical and Manufacturing Engineering, Rapid Manufacturing Research Group, Loughborough University, LE11 3TU, UK. haoliang@pmail.ntu.edu.sg
authors.forename: L
authors.initials: L
authors.lastname: Hao
authors.forename: J
authors.initials: J
authors.lastname: Lawrence
authors.forename: K S
authors.initials: KS
authors.lastname: Chian
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000528:radiation effects; D002448:Cell Adhesion / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology; D002478:Cells, Cultured; D003776:Dental Porcelain / Q000032:analysis / Q000737:chemistry* / Q000528:radiation effects; D006801:Humans; D007834:Lasers; D008422:Materials Testing; D016348:Osseointegration / Q000502:physiology*; D010006:Osteoblasts / Q000166:cytology* / Q000502:physiology*; D013499:Surface Properties; D015019:Yttrium / Q000032:analysis / Q000737:chemistry* / Q000528:radiation effects; D015040:Zirconium
chemical_list: D001672:Biocompatible Materials; C499362:yttria stabilized tetragonal zirconia; D003776:Dental Porcelain; D015019:Yttrium; D015040:Zirconium