title: Immune pre-activation exacerbates hemorrhagic brain injury in immature mouse brain.
abstract: Premature infants with placental infection and adult stroke patients with fever have worse outcomes following intracerebral hemorrhage (ICH). We hypothesized that immune pre-activation would aggravate brain injury in mouse brain following ICH. The immune system of 2-day, 10-day and 7-week young adult CD1 mice was stimulated by intraperitoneal injection of concanavalin A (ConA), lipopolysaccharide (LPS) or polyinosinic-polycytidilic acid (PolyI:C) 12 h prior to intracerebral injection of blood. Two days later, brain damage and inflammation were worse in 2-day mice that had received LPS. The other agents had less consistent effects in 2-day mice. Brain damage in young adults was aggravated less after immune stimulation. These data suggest that immune pre-activation modifies hemorrhagic brain injury in immature mouse brain.
authors.affiliation: Department of Pathology, University of Manitoba and Manitoba Institute of Child Health, D212-770 Bannatyne Ave, Winnipeg, MB, Canada, R3E 0W3.
authors.forename: Mengzhou
authors.initials: M
authors.lastname: Xue
authors.forename: Marc R
authors.initials: MR
authors.lastname: Del Bigio
mesh_terms: D000375:Aging / Q000276:immunology / Q000473:pathology; D000818:Animals; D000831:Animals, Newborn; D001803:Blood Transfusion; D001921:Brain / Q000098:blood supply / Q000276:immunology* / Q000473:pathology*; D002543:Cerebral Hemorrhage / Q000276:immunology* / Q000401:mortality / Q000473:pathology*; D003208:Concanavalin A / Q000008:administration & dosage; D005260:Female; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D007371:Interferon-gamma / Q000172:deficiency / Q000235:genetics; D008070:Lipopolysaccharides / Q000008:administration & dosage; D008213:Lymphocyte Activation / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011070:Poly I-C / Q000008:administration & dosage
chemical_list: D008070:Lipopolysaccharides; D003208:Concanavalin A; D007371:Interferon-gamma; D011070:Poly I-C