Thyroid function after assisted reproductive technology in women free of thyroid disease.
OBJECTIVE
To evaluate thyroid function in women undergoing a first assisted reproductive technology (ART) procedure and to compare women with ongoing pregnancy or miscarriage.


METHODS
Prospective cohort study.


METHODS
Tertiary referral center.


METHODS
Seventy-seven women free of thyroid disease.


METHODS
Serum TSH and FT4 were determined before and 2, 4, and 6 weeks after ET. All women received the same ART protocol.


METHODS
Thyroid function.


RESULTS
Forty-five women had ongoing pregnancies, and 32 suffered a miscarriage after 6.7 weeks (range 5-11). Mean age and number of ET were similar in both groups. Compared with baseline values, TSH and FT4 increased significantly 2 weeks after ET (ongoing pregnancies group: TSH 2.5 +/- 1.3 vs. 1.6 +/- 0.8 mU/L and FT4 13.8 +/- 1.4 vs. 12.4 +/- 1.8 ng/L; miscarriage group: TSH 2.1 +/- 1.0 vs. 1.5 +/- 0.7 mU/L and FT4 14.2 +/- 2.0 vs. 12.4 +/- 1.9 ng/L). Pregnancy outcome did not affect thyroid function and its evolution over time.


CONCLUSIONS
In women free of thyroid diseases, thyroid function changed significantly after ART, but these changes were not different between women with ongoing pregnancy and miscarriage.
Poppe
Kris
K
Department of Endocrinology, Vrije Universiteit Brussel, Brussels, Belgium. hemopek@az.vub.ac.be
Glinoer
Daniel
D
Tournaye
Herman
H
Schiettecatte
Johan
J
Haentjens
Patrick
P
Velkeniers
Brigitte
B
D000022:Abortion, Spontaneous / Q000097:blood / Q000453:epidemiology; D000328:Adult; D000704:Analysis of Variance; D005260:Female; D006801:Humans; D011247:Pregnancy; D011446:Prospective Studies; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects / Q000706:statistics & numerical data; D013959:Thyroid Diseases / Q000097:blood* / Q000453:epidemiology; D013960:Thyroid Function Tests / Q000706:statistics & numerical data; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D013997:Time Factors
D013972:Thyrotropin; D013974:Thyroxine