title: Anaesthesia for electroconvulsive therapy: a comparison of sevoflurane with propofol.
abstract: This study was a prospective audit of patients receiving either intravenous induction of anaesthesia with propofol 2 mg/kg or inhalational induction using 8% sevoflurane for patients undergoing electroconvulsive therapy (ECT). All patients received inhaled 50% nitrous oxide. The anaesthetic agent was determined by psychiatrist preference. Each psychiatrist nominated only one induction technique for all his or her patients. Seventy treatments were studied in each group. Induction time was longer in the sevoflurane group. The time from commencing induction to loss of verbal contact was [mean (SD)] 64 (29.9) seconds for sevoflurane and 36 (33.6) seconds for propofol (P=0.001). Time to loss of eyelash reflex was 82 (32.6)s for sevoflurane and 44 (17.9)s for propofol (P<0.001). The duration of seizure activity was longer in sevoflurane patients, 35 (17.8)s, compared with 20 (9.8)s in the propofol group (P< 0.001). Discharge times were similar Minor adverse effects occurred in three patients, all in the sevoflurane group (one bradycardia and two episodes of post-procedural nausea). There were no major adverse events in either group. Propofol and sevoflurane both appear to be suitable agents for induction of anaesthesia for ECT.
authors.affiliation: Department of Anaesthesiology, University of Natal, Entabeni Hospital and Westville Hospital, Durban, South Africa.
authors.forename: R E
authors.initials: RE
authors.lastname: Hodgson
authors.forename: P
authors.initials: P
authors.lastname: Dawson
authors.forename: A R
authors.initials: AR
authors.lastname: Hold
authors.forename: C C
authors.initials: CC
authors.lastname: Rout
authors.forename: K
authors.initials: K
authors.lastname: Zuma
mesh_terms: D000328:Adult; D000758:Anesthesia; D018685:Anesthetics, Inhalation / Q000494:pharmacology; D018686:Anesthetics, Intravenous / Q000494:pharmacology; D016022:Case-Control Studies; D003866:Depressive Disorder / Q000628:therapy; D004565:Electroconvulsive Therapy; D005260:Female; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology; D009609:Nitrous Oxide; D015742:Propofol / Q000494:pharmacology; D011446:Prospective Studies; D012121:Respiration, Artificial; D012640:Seizures / Q000209:etiology; D000077149:Sevoflurane; D013997:Time Factors
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D000077149:Sevoflurane; D009609:Nitrous Oxide; D015742:Propofol