Soy protein influences the development of the metabolic syndrome in male obese ZDFxSHHF rats.
Previous investigations have demonstrated a marked effect of soy protein on the metabolic syndrome (MS). The purpose of this preliminary study was to identify the effects of soy-based diets on male obese ZDFxSHHF (fa/ fa-cp/?) rats. Animals were randomly assigned to one of four diets: control, casein (C); low-isoflavone (LIS) soy protein; high-isoflavone (HIS) soy protein; or casein + rosiglitazone (CR). Physiological, biochemical, and molecular parameters were determined at sacrifice. Body weight (p < 0.01) and food intake (p < 0.05) were lower in LIS-fed rodents. Rosiglitazone-treated animals had higher body weight and adiposity (p < 0.05). LIS and CR groups exhibited better glycemic control (p < 0.05), but with a limited effect in rosiglitazone-treated animals. HIS fed rats had higher glucose and triacylglyceride levels (p < 0.01), and lower plasma insulin (p < 0.01). Renal function parameters with the exception of an increase in systolic blood pressure (p < 0.05) were all suppressed in the LIS group (p < 0.01). The CR group had twofold PPARalpha and PPARgamma mRNA abundance (p < 0.01). LIS-fed animals also exhibited greater abundance of PPARgamma mRNA (p < 0.001), and nearly threefold FAS and CPT-1 mRNA levels (p < 0.05). HIS-fed rats also had higher abundance of CPT-1 mRNA, as well as a lower abundance of ACC mRNA (p < 0.05). Soy-based diets, influenced by isoflavone content and distinct from rosiglitazone, improved several metabolic parameters in obese ZDFxSHHF rats.
Davis
J
J
Department of Animal Science, Food & Nutrition, Southern Illinois University, Carbondale, IL 62901-4317, USA.
Iqbal
M J
MJ
Steinle
J
J
Oitker
J
J
Higginbotham
D A
DA
Peterson
R G
RG
Banz
W J
WJ
D000818:Animals; D008297:Male; D008659:Metabolic Diseases / Q000178:diet therapy / Q000209:etiology / Q000378:metabolism*; D009765:Obesity / Q000150:complications / Q000178:diet therapy / Q000378:metabolism*; D051381:Rats; D030262:Soybean Proteins / Q000008:administration & dosage*
D030262:Soybean Proteins