Cost-effectiveness of universal childhood hepatitis A vaccination in Chile.
Hepatitis A is an important public health problem in Chile. Childhood vaccination has reduced hepatitis A rates in several countries, prompting this evaluation of its cost-effectiveness in Chile. Using a Markov model, we project mass vaccination would reduce hepatitis A cases among birth cohort members and their personal contacts >80%. Vaccination costs of US dollars 5.3-6.4 million would be offset by US dollars 9.2-9.4 million reductions in disease costs. Further, approximately 70 fatal infections would be averted and >4600 quality-adjusted life years would be saved. This analysis supports the cost-effectiveness of universal childhood hepatitis A vaccination in Chile.
Valenzuela
M Teresa
MT
School of Public Health, Faculty of Medicine, University of Chile, Santiago, Chile.
Jacobs
R Jake
RJ
Arteaga
Oscar
O
Navarrete
Maria S
MS
Meyerhoff
Allen S
AS
Innis
Bruce L
BL
D002675:Child, Preschool; D002677:Chile / Q000453:epidemiology; D003362:Cost-Benefit Analysis; D017048:Health Care Costs; D006506:Hepatitis A / Q000191:economics / Q000453:epidemiology / Q000517:prevention & control*; D022362:Hepatitis A Vaccines / Q000008:administration & dosage / Q000191:economics*; D017957:Hepatitis A Virus, Human / Q000276:immunology*; D006801:Humans; D017589:Immunization Programs / Q000191:economics*; D007115:Immunization Schedule; D007223:Infant; D014611:Vaccination / Q000191:economics / Q000379:methods
D022362:Hepatitis A Vaccines