Toxic hepatitis associated with paroxetine.
Hepatotoxicity is a rare complication of paroxetine, a selective serotonin reuptake inhibitor. Regarded as safe in therapeutic use, there have been reports of cases of severe hepatic dysfunction with gross elevations of transaminase levels that may be related to this drug. We report here severe adverse cholestatic and hepatocellular injury in a patient taking paroxetine probably due to an immune-mediated hypersensitivity reaction.
Colakoglu
O
O
Gastroenterology Clinics, Ataturk Training and Research Hospital, Izmir, Turkey. ondercl@superonline.com
Tankurt
E
E
Unsal
B
B
Ugur
F
F
Kupelioglu
A
A
Buyrac
Z
Z
Akpinar
Z
Z
D000928:Antidepressive Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000276:immunology; D003866:Depressive Disorder / Q000188:drug therapy; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000150:complications; D008297:Male; D008875:Middle Aged; D017374:Paroxetine / Q000009:adverse effects*
D000928:Antidepressive Agents; D017374:Paroxetine