title: Long-term results of topical glyceryl trinitrate ointment in children with anal fissure.
abstract: OBJECTIVE
  Although topical glyceryl trinitrate ointment (GTN) has become a popular treatment for anal fissure in adults, its use in children is still limited. We aimed to determine the effectiveness and safety of topical GTN in the long-term management of anal fissure in children, which has not yet been reported.
  
  
  METHODS
  Thirty-one children with anal fissure who received topical 0.2% GTN treatment between 1997 and 1998 were evaluated in 2004.
  
  
  RESULTS
  Ten patients had one or more relapses after initial treatment with 0.2% GTN, all within 1 year of first onset of anal fissure. No further recurrences were diagnosed during the 4-year follow-up period.
  
  
  CONCLUSIONS
  Although early recurrence can occur, topical GTN ointment is effective in healing chronic anal fissures in children.
authors.affiliation: Department of Pediatric Surgery, Gülhane Military Medical Academy, Ankara, Turkey. sdemirbag@gata.edu.tr
authors.forename: S
authors.initials: S
authors.lastname: Demirbag
authors.forename: B
authors.initials: B
authors.lastname: Tander
authors.forename: C
authors.initials: C
authors.lastname: Atabek
authors.forename: I
authors.initials: I
authors.lastname: Surer
authors.forename: H
authors.initials: H
authors.lastname: Oztürk
authors.forename: S
authors.initials: S
authors.lastname: Cetinkursun
mesh_terms: D000287:Administration, Topical; D001003:Anal Canal; D002648:Child; D002908:Chronic Disease; D005260:Female; D005401:Fissure in Ano / Q000188:drug therapy*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D005996:Nitroglycerin / Q000008:administration & dosage* / Q000627:therapeutic use; D009824:Ointments; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D014945:Wound Healing
chemical_list: D009824:Ointments; D014665:Vasodilator Agents; D005996:Nitroglycerin