title: Anemia due to losartan in hypertensive renal transplant recipients without posttransplant erythrocytosis.
abstract: Losartan is a safe, effective long-term treatment for hypertension or posttransplant erythrocytosis (PTE) in renal transplant recipients. There were only a few studies in patients without PTE and their results were different. Starting from week 6 and continuing to the week 12 we observed a decrease in hemoglobin (Hb) and hematocrit (Hct) levels in patients without PTE. Anemia developed in 42.8% of the patients, and Hb levels increased after the withdrawal of losartan treatment. There was a significant decrease in Hct levels beginning from week 3 when compared with the control group. Our study suggests that losartan therapy can decrease Hb beyond its antihypertensive efficacy. Based on the capacity of losartan to decrease Hb and Hct, this drug should be carefully used in patients with preexistent anemia or low Hb levels.
authors.affiliation: Department of Nephrology, Uludağ University Medical School, 16059 Gorukle/Bursa, Turkey. alpersoy@uludag.edu.tr
authors.forename: A
authors.initials: A
authors.lastname: Ersoy
authors.forename: S
authors.initials: S
authors.lastname: Kahvecioglu
authors.forename: C
authors.initials: C
authors.lastname: Ersoy
authors.forename: A
authors.initials: A
authors.lastname: Cift
authors.forename: K
authors.initials: K
authors.lastname: Dilek
mesh_terms: D000328:Adult; D000740:Anemia / Q000139:chemically induced*; D000959:Antihypertensive Agents / Q000009:adverse effects; D015992:Body Mass Index; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D004906:Erythrocyte Count; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D016030:Kidney Transplantation / Q000009:adverse effects*; D019808:Losartan / Q000009:adverse effects*; D008297:Male; D011086:Polycythemia
chemical_list: D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D006454:Hemoglobins; D003404:Creatinine; D019808:Losartan