Immediate withdrawal from chronic "binge" cocaine administration increases mu-opioid receptor mRNA levels in rat frontal cortex.
An increase in preprodynorphin (ppdyn) mRNA was detected in the caudate putamen of chronically cocaine-treated and 3-h withdrawn rats. An increase in mu-opioid receptor (MOP) mRNA levels was observed in the frontal cortex of 3-h withdrawn rats. Naloxone had no effect on the increase of MOP or ppdyn mRNA levels. The results indicate that the opioid system is altered during early withdrawal from chronic cocaine administration.
Bailey
Alexis
A
Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA. baileya@rockefeller.edu
Yuferov
Vadim
V
Bendor
Jacob
J
Schlussman
Stefan D
SD
Zhou
Yan
Y
Ho
Ann
A
Kreek
Mary Jeanne
MJ
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects* / Q000502:physiology; D003042:Cocaine / Q000494:pharmacology*; D019970:Cocaine-Related Disorders / Q000378:metabolism* / Q000503:physiopathology; D004195:Disease Models, Animal; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology; D015536:Down-Regulation / Q000187:drug effects / Q000235:genetics; D004334:Drug Administration Schedule; D004745:Enkephalins / Q000235:genetics; D005625:Frontal Lobe / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D009292:Narcotic Antagonists / Q000494:pharmacology; D011498:Protein Precursors / Q000235:genetics; D012333:RNA, Messenger / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344; D017450:Receptors, Opioid, mu / Q000235:genetics*; D013375:Substance Withdrawal Syndrome / Q000378:metabolism* / Q000503:physiopathology; D013997:Time Factors
D018765:Dopamine Uptake Inhibitors; D004745:Enkephalins; D009292:Narcotic Antagonists; D011498:Protein Precursors; D012333:RNA, Messenger; D017450:Receptors, Opioid, mu; C033660:preproenkephalin; D003042:Cocaine