title: Bilateral upper eyelid edema in Melkersson-Rosenthal syndrome.
abstract: Melkersson-Rosenthal syndrome is an uncommon disorder characterized by a triad of facial nerve palsy, orofacial edema, and fissured tongue. A 42-year-old woman with Melkersson-Rosenthal syndrome presented with painless, nonpitting, bilateral asymmetric upper eyelid edema. The left eyelid was a bit larger than the right eyelid. CT and MRI demonstrated periorbital soft tissue thickening compatible with the microscopic findings of infiltration of lymphocytes, edema, and cystic dilatation of lymphatic vessels. After treatment by systemic doxycycline and corticosteroid, she showed some improvement of the eyelid edema. Isolated bilateral eyelids swelling may be observed in Melkersson-Rosenthal syndrome. In the case of unexplained nonpitting eyelid edema, biopsy should be performed.
authors.affiliation: Department of Ophthalmology, University of Kirikkale, Kirikkale, Turkey. cengizakarsu@hotmail.com
authors.forename: Cengiz
authors.initials: C
authors.lastname: Akarsu
authors.forename: Pinar
authors.initials: P
authors.lastname: Atasoy
authors.forename: Sibel
authors.initials: S
authors.lastname: Erdoğan
authors.forename: Mukadder
authors.initials: M
authors.lastname: Koçak
mesh_terms: D000328:Adult; D004318:Doxycycline / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004487:Edema / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005141:Eyelid Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D008556:Melkersson-Rosenthal Syndrome / Q000150:complications*; D014057:Tomography, X-Ray Computed
chemical_list: D005938:Glucocorticoids; D004318:Doxycycline