title: Small hepatocellular carcinoma associated with Wilson's disease.
abstract: We report a 66-year-old male patient with hepatocellular carcinoma (HCC) associated with Wilson's disease. The patient presented with unresolving abnormal liver function test, decreased serum ceruloplasmin levels and increased 24-hour urine copper excretion. Liver biopsy specimen revealed the presence of increased levels of copper and features suggestive of Wilson's disease. Abdominal imaging showed the existence of a small HCC. Three years after chemoembolization and microwave coagulation therapy for HCC, he died of hepatic failure, which apparently resulted from chemoembolization. Patients with Wilson's disease should be screened for HCC. We should elude therapies such as chemoembolization in these patients.
authors.affiliation: Third Department of Internal Medicine, Ehime University School of Medicine, Japan.
authors.forename: Teru
authors.initials: T
authors.lastname: Kumagi
authors.forename: Norio
authors.initials: N
authors.lastname: Horiike
authors.forename: Masanori
authors.initials: M
authors.lastname: Abe
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Kurose
authors.forename: Hideto
authors.initials: H
authors.lastname: Iuchi
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Masumoto
authors.forename: Koji
authors.initials: K
authors.lastname: Joko
authors.forename: Sk Fazle
authors.initials: SF
authors.lastname: Akbar
authors.forename: Kojiro
authors.initials: K
authors.lastname: Michitaka
authors.forename: Morikazu
authors.initials: M
authors.lastname: Onji
mesh_terms: D001706:Biopsy; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D002570:Ceruloplasmin / Q000378:metabolism; D016461:Chemoembolization, Therapeutic; D003300:Copper / Q000652:urine; D003937:Diagnosis, Differential; D003972:Diathermy / Q000379:methods; D017809:Fatal Outcome; D006527:Hepatolenticular Degeneration / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008113:Liver Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D008297:Male; D008872:Microwaves; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D003300:Copper; D002570:Ceruloplasmin