Unzipped and loaded: the role of DNA helicases and RFC clamp-loading complexes in sister chromatid cohesion.
It is well known that the products of chromosome replication are paired to ensure that the sisters segregate away from each other during mitosis. A key issue is how cells pair sister chromatids but preclude the catastrophic pairing of nonsister chromatids. The identification of both replication factor C and DNA helicases as critical for sister chromatid pairing has brought new insights into this fundamental process.
Skibbens
Robert V
RV
Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA. rvs3@lehigh.edu
D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics; D002868:Chromosomal Proteins, Non-Histone; D023902:Chromosome Pairing / Q000235:genetics*; D020090:Chromosome Segregation / Q000235:genetics*; D004265:DNA Helicases / Q000235:genetics*; D004261:DNA Replication / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D005656:Fungal Proteins / Q000235:genetics; D006801:Humans; D008938:Mitosis / Q000235:genetics*; D008957:Models, Genetic; D009687:Nuclear Proteins / Q000235:genetics; D051818:Replication Protein C; D000097722:Cohesins
D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D004265:DNA Helicases; D004268:DNA-Binding Proteins; D005656:Fungal Proteins; D009687:Nuclear Proteins; D051818:Replication Protein C; D000097722:Cohesins