Photocontrolling peptide alpha helices.
Reversible optical control of protein structure and function offers the possibility of probing and manipulating individual proteins within the complex environment of a living cell. As a first step toward creating artificial photocontrolled proteins, we have designed and synthesized reversible, photocontrolled peptide alpha helices. Here, I attempt to summarize the lessons learned from that endeavor.
Woolley
G Andrew
GA
Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada. awoolley@chem.utoronto.ca
D000595:Amino Acid Sequence; D007536:Isomerism; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*; D010777:Photochemistry; D017433:Protein Structure, Secondary
D010455:Peptides