Development of activity standard for 90 Y microspheres.
(90)Y microspheres are important therapeutic radiopharmaceuticals used in the treatment of liver cancer through a process known as selective internal radiation therapy. SIR-spheres is a radiopharmaceutical product that is comprised of (90)Y microspheres suspended in sterile, pyrogen-free water for injection into patients. It is necessary to establish for the SIR-spheres production the capability of accurately measuring the activity of this product to a traceable national measurement standard. An activity standard for SIR-spheres was developed from a standard for (90)Y solution, employing a highly quantifiable chemical digestion process. Calibration factors for the manufacturer's ionisation chambers were determined for 1 and 5 ml of the SIR-spheres product placed in Wheaton vials, for both 34% and 44% of (90)Y microsphere concentration.
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Australian Nuclear Science and Technology Organisation, New Illawarra Road, Lucas Heights, NSW 2234, Australia. Imx@ansto.gov.au
Avci
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James
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Simpson
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Van Wyngaardt
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Cessna
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Baldock
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D001315:Australia; D002138:Calibration / Q000592:standards; D017408:Guidelines as Topic; D008422:Materials Testing / Q000379:methods / Q000592:standards; D008863:Microspheres; D011785:Quality Assurance, Health Care / Q000379:methods / Q000592:standards*; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods* / Q000592:standards*; D019275:Radiopharmaceuticals / Q000032:analysis* / Q000592:standards* / Q000627:therapeutic use; D012015:Reference Standards; D015021:Yttrium Radioisotopes / Q000032:analysis* / Q000592:standards* / Q000627:therapeutic use
D019275:Radiopharmaceuticals; D015021:Yttrium Radioisotopes