High-resolution cDNA microarray-based comparative genomic hybridization analysis in neuroblastoma.
Neuroblastoma (NB) is one of the most common pediatric solid tumors and displays a broad variety of genomic alterations. Array-based comparative genomic hybridization (A-CGH) is a novel technology enabling the high-resolution detection of DNA copy number aberrations. In this article, we outline features of this new technology and approaches of data analysis. We focus on stage specific DNA copy number variations in neuroblastoma detected by cDNA array-based comparative genomic hybridization (A-CGH). We also discuss hypothetic evolutionary models of neuroblastoma progression that can be derived from A-CGH data.
Chen
Qing-Rong
QR
Oncogenomics Section, Pediatric Oncology Branch, Advanced Technology Center, National Cancer Institute, 8717 Government Circle, Gaithersburg, MD 20877, USA. chenqi@mail.nih.gov
Bilke
Sven
S
Khan
Javed
J
D018076:DNA, Complementary / Q000235:genetics*; D006801:Humans; D009447:Neuroblastoma / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D020411:Oligonucleotide Array Sequence Analysis; D011336:Probability
D018076:DNA, Complementary