[Efficiency of treatment of Candida-induced lower respiratory tract lesions in patients with pulmonary tuberculosis].
The paper describes the results of a clinical trial of itraconasole as suspension in the treatment of Candida-induced lower respiratory tract lesions in patients with pulmonary tuberculosis. The first course of the therapy stopped the growth of fungal culture in 34 (68%) patients; after its repeated course, there were 42 (84%) recovered patients out of 50. After the first course of orangul therapy, there was a decrease in the titer of fungal growth in 15 (30%) patients. The repeated course of the therapy resulted in fungal eradication in 8 of the 15 patients, a further decrease in the baseline titer of the fungi was observed in 4 patients. The treatment was ineffective only in 1 (2%) patient, which was associated with the progression of disseminated pulmonary tuberculosisand with the presence of the dose-dependent fungal strain C. glabrata.
Lovacheva
O V
OV
Kornienko
I I
II
Kul'ko
A B
AB
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage*; D000995:Antitubercular Agents / Q000627:therapeutic use; D001980:Bronchi / Q000382:microbiology; D001991:Bronchitis / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D002175:Candida / Q000302:isolation & purification*; D002177:Candidiasis / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D015169:Colony Count, Microbial; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage*; D008875:Middle Aged; D013183:Sputum / Q000382:microbiology; D013535:Suspensions; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000150:complications* / Q000188:drug therapy
D000935:Antifungal Agents; D000995:Antitubercular Agents; D013535:Suspensions; D017964:Itraconazole