Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES-62.
Secretion of immunomodulatory molecules is a key strategy employed by pathogens to enable their survival in host organisms. For example, arthropod-transmitted filarial nematodes, which achieve longevity within the infected host by suppressing and modulating the host immune response, produce excretory-secretory (ES) products that have been demonstrated to possess immunomodulatory properties. In this review we discuss the immunomodulatory effects of the phosphorylcholine-containing filarial nematode-secreted glycoprotein ES-62 and describe the intracellular signal transduction pathways it targets to achieve these effects.
Goodridge
Helen S
HS
Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, UK.
Stepek
Gillian
G
Harnett
William
W
Harnett
Margaret M
MM
D000818:Animals; D000917:Antibody Formation / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D005368:Filariasis / Q000276:immunology; D005370:Filarioidea / Q000276:immunology*; D006023:Glycoproteins / Q000276:immunology; D015801:Helminth Proteins / Q000276:immunology*; D006801:Humans; D008264:Macrophages / Q000276:immunology; D010767:Phosphorylcholine / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
C435884:ES-62 protein, Acanthocheilonema viteae; D006023:Glycoproteins; D015801:Helminth Proteins; D010767:Phosphorylcholine