[The role of gastroesophageal reflux in malignization of post-burn and peptic esophageal strictures].
The subjects of the study were 221 patients with cicatrical esophageal strictures. 62 (28.5%) patients had peptic strictures, and 159 (71.9%)--post-burn strictures. 67 (30.3%) patients underwent esophageal resection with one-stage intrapleural esophagoplasty with the stomach, 152 (68.8%) patients--gullet bougienage in combination with surgical intervention or as an only treatment. The study revealed 8 cases of squamous cell carcinoma in patients with post-burn strictures, and 3 cases of squamous cell carcinoma in patients with peptic strictures. In 2 cases the researchers found early stage of esophageal cancer (verrucose carcinoma)--in 1 patient with post-burn stricture and 1 patient with peptic stricture. The results suggest an important role of chronic gastroesophageal reflux in the oncogenesis of esophageal squamous cell carcinoma in patients with post-burn and peptic strictures.
Allakhverdian
A S
AS
Mazurin
V S
VS
Kazantseva
I A
IA
Isakov
V A
VA
Titov
A G
AG
Morozov
S V
SV
Zafirov
A G
AG
D000328:Adult; D001706:Biopsy; D002057:Burns, Chemical / Q000150:complications* / Q000473:pathology; D018289:Carcinoma, Verrucous / Q000209:etiology / Q000473:pathology; D002908:Chronic Disease; D002921:Cicatrix; D018450:Disease Progression; D004938:Esophageal Neoplasms / Q000209:etiology* / Q000473:pathology; D004940:Esophageal Stenosis / Q000150:complications* / Q000473:pathology; D004942:Esophagitis, Peptic / Q000150:complications* / Q000473:pathology; D004947:Esophagus / Q000293:injuries*; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D012189:Retrospective Studies