[Analysis of heart rate variability in assessment of baroreflex sensitivity in anesthetized rats].
Spectral analysis of the heart rate variability can be used as a measure of baroreflex sensitivity in ketamine anesthetized rats. Stimulation of delta1-receptors with phenylephrine (0.01 mg/kg, i.v.) results in a rise of the strength of heart rate regulation, principally in the low frequency band. Maximal deviations of spectral indexes from basal level were observed on 4-8 min for low (0.2-1 Hz) and high (1-3 Hz) frequencies bands and on 10-15 min for very low (0.08-0.2 Hz) frequency band after phenylephrine injection.
Khripachenko
I A
IA
Donetsk Medical University.
Savust'ianenko
A V
AV
Kedenko
L A
LA
Zinkovych
I I
II
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000704:Analysis of Variance; D000758:Anesthesia; D000818:Animals; D017704:Baroreflex / Q000187:drug effects / Q000502:physiology*; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats
D000316:Adrenergic alpha-Agonists; D010656:Phenylephrine