Hox clusters as models for vertebrate genome evolution.
The surprising variation in the number of Hox clusters and the genomic architecture within vertebrate lineages, especially within the ray-finned fish, reflects a history of duplications and subsequent lineage-specific gene loss. Recent research on the evolution of conserved non-coding sequences (CNS) in Hox clusters promises to reveal interesting results for functional and phenotypic diversification.
Hoegg
Simone
S
Lehrstuhl für Zoologie und Evolutionsbiologie, Department of Biology, University of Konstanz, 78457 Konstanz, Germany.
Meyer
Axel
A
D000818:Animals; D001483:Base Sequence; D017124:Conserved Sequence; D004247:DNA / Q000235:genetics; D019143:Evolution, Molecular; D005399:Fishes / Q000235:genetics; D020440:Gene Duplication; D005801:Genes, Homeobox; D016678:Genome; D006801:Humans; D008957:Models, Genetic; D005810:Multigene Family; D012689:Sequence Homology, Nucleic Acid; D014714:Vertebrates / Q000235:genetics
D004247:DNA