title: The genomic island SGI1, containing the multiple antibiotic resistance region of Salmonella enterica serovar Typhimurium DT104 or variants of it, is widely distributed in other S. enterica serovars.
abstract: The global dissemination of the multiply-antibiotic-resistant Salmonella enterica serovar Typhimurium DT104 clone with the resistance genes located in a class 1 integron, here designated In104, within genomic island SGI1 is a significant public health issue. Here, we have shown that SGI1 and variants of it carrying different combinations of resistance genes are found in several Salmonella enterica serovars. These are serovars Cerro, Derby, Dusseldorf, Infantis, Kiambu, and Paratyphi B dT(+) isolated from human infections and serovar Emek from sewage effluent. Two new variants, SGI1-I and SGI1-J, both of which include the dfrA1-orfC cassette array, were identified.
authors.affiliation: New South Wales Department of Primary Industries, Private Mail Bag 8, Camden, New South Wales 2570, Australia.
authors.forename: Renee S
authors.initials: RS
authors.lastname: Levings
authors.forename: Diane
authors.initials: D
authors.lastname: Lightfoot
authors.forename: Sally R
authors.initials: SR
authors.lastname: Partridge
authors.forename: Ruth M
authors.initials: RM
authors.lastname: Hall
authors.forename: Steven P
authors.initials: SP
authors.lastname: Djordjevic
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001315:Australia; D018432:Drug Resistance, Multiple / Q000235:genetics; D044404:Genomic Islands / Q000187:drug effects*; D006801:Humans; D032023:Integrons; D008969:Molecular Sequence Data; D012480:Salmonella Infections / Q000382:microbiology; D012481:Salmonella Infections, Animal / Q000382:microbiology; D019779:Salmonella enterica / Q000235:genetics*; D012485:Salmonella typhi / Q000187:drug effects* / Q000235:genetics; D012722:Sewage / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D012722:Sewage