title: Platypnea-orthodeoxia syndrome combined with multiple congenital heart anomalies.
abstract: A 71-year-old woman was admitted for paralysis on the left side of her body. She developed dyspnea and hypoxemia after admission. Although pulmonary embolism was suspected, hypoxemia and dyspnea occurred repeatedly in spite of anticoagulation therapy. Transesophageal echocardiography revealed a patent foramen ovale (PFO), an atrial septal aneurysm (ASA), and a right-to-left shunt that appeared in an upright position. She was diagnosed with platypnea-orthodeoxia syndrome. Moreover, cardiac catheterization showed congenital anomalies, such as unroofed coronary sinus, partial anomalous pulmonary venous return and persistent left superior vena cava. Simple surgical closure of the ASA and PFO improved all of her symptoms.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Nagayoshi
authors.forename: Kensuke
authors.initials: K
authors.lastname: Toyama
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kawano
authors.forename: Ikuo
authors.initials: I
authors.lastname: Misumi
authors.forename: Shinzo
authors.initials: S
authors.lastname: Miyamoto
authors.forename: Sunao
authors.initials: S
authors.lastname: Kojima
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Michihiro
authors.initials: M
authors.lastname: Yoshimura
authors.forename: Hisao
authors.initials: H
authors.lastname: Ogawa
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis / Q000601:surgery; D000368:Aged; D006328:Cardiac Catheterization; D006348:Cardiac Surgical Procedures; D017023:Coronary Angiography; D003330:Coronary Vessel Anomalies / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D004417:Dyspnea / Q000175:diagnosis / Q000209:etiology*; D018618:Echocardiography, Doppler, Color; D017548:Echocardiography, Transesophageal; D005260:Female; D006322:Heart Aneurysm / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D006344:Heart Septal Defects, Atrial / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D000860:Hypoxia / Q000175:diagnosis / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D011187:Posture; D013577:Syndrome