Growth hormone secretion and insulin-like growth factor-1 are related to hyperandrogenism in nonobese patients with polycystic ovary syndrome.
Women of normal weight with polycystic ovary syndrome (PCOS) and hyperinsulinemia presented high growth hormone (GH) levels in response to the l-dopa test, suggesting that the action of GH and insulin-like growth factor-1 (IGF-1) might be responsible for the elevation in LH and the consequent hyperandrogenic anovulation observed in normal weight women with PCOS. Insulin resistance and obesity are related to a reduction in GH secretion in obese women with PCOS.
Premoli
Ana Cristina
AC
Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
Santana
Laura Ferreira
LF
Ferriani
Rui Alberto
RA
Moura
Marcos Dias de
MD
De Sá
Marcos Felipe Silva
MF
Reis
Rosana Maria dos
RM
D000328:Adult; D005260:Female; D019382:Human Growth Hormone / Q000097:blood* / Q000378:metabolism*; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D009765:Obesity / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D011446:Prospective Studies
D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I