title: [Clinical pathology, diagnosis, and treatment of mixed growth hormone-and prolactin cell adenoma].
abstract: OBJECTIVE
  To discuss the clinical pathology and management of mixed growth hormone- and prolactin (GH-PRL) cell adenoma.
  
  
  METHODS
  Eight patients (4 men and 4 women, with the mean age of 32.3 year old and duration of symptoms 12 months) underwent examination of serum endocrine and magnetic resonance imaging. Clinical manifestations included headache, physiognomy of acromegalic patient, large pudgy hands and foots, menstrual dysfunction, amenorrhea, galactorrhea, and descending vision. Patients underwent transsphenoidal microsurgery of mixed GH-PRL pituitary adenoma between 1986 and 2004.
  
  
  RESULTS
  The hypersecretion of GH and PRL was relieved after operation. Headache was obviously improved in all patients. In 5 cases the menstrual dysfunction and amenorrhea were recovered. In 4 cases the galactorrhea and descending vision disappeared.
  
  
  CONCLUSIONS
  The diagnosis of mixed GH-PRL pituitary adenoma can be made according to the results examination of serum endocrine, pathology and clinical manifestations. Its endocrine features are related to the invasion extent of the adenoma. The transsphenoidal approach is the preferred treatment for mixed GH-PRL pituitary adenoma.
authors.affiliation: Department of Neurosurgery, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors.forename: Ming-dong
authors.initials: MD
authors.lastname: Wang
authors.forename: Wen-bin
authors.initials: WB
authors.lastname: Ma
authors.forename: Mei
authors.initials: M
authors.lastname: Guo
authors.forename: Yan-fang
authors.initials: YF
authors.lastname: Shi
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.forename: Ren-zhi
authors.initials: RZ
authors.lastname: Wang
authors.forename: Di
authors.initials: D
authors.lastname: Yang
authors.forename: Chuan
authors.initials: C
authors.lastname: Fang
mesh_terms: D000236:Adenoma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D000293:Adolescent; D000328:Adult; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D008297:Male; D010911:Pituitary Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D011388:Prolactin / Q000378:metabolism*; D015175:Prolactinoma / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology
chemical_list: D011388:Prolactin; D013006:Growth Hormone