title: A case of osteoclast-like giant cell tumor of the pancreas with ductal adenocarcinoma: histopathological, immunohistochemical, ultrastructural and molecular biological studies.
abstract: Osteoclast-like giant cell tumor of the pancreas is a very rare neoplasm, of which the histiogenesis remains controversial. A 63-yr-old woman was hospitalized for evaluation of epigastric pain. An abdominal computerized tomography revealed the presence of a large cystic mass, arising from the tail of pancreas. A distal pancreatectomy with splenectomy was performed. Histologically, the tumor was composed of mononuclear stromal cells intermingled with osteclast-like giant cells. In addition, there was a small area of moderately to well differentiated ductal adenocarcinoma. The final pathologic diagnosis was osteoclast-like giant cell tumor of the pancreas with ductal adenocarcinoma. Here, we describe the histopathological, immunohistochemical, ultrastructural and molecular biological findings of this tumor with review of the literature pertaining to this condition.
authors.affiliation: Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea. mareejb@netian.com
authors.forename: Young-Eun
authors.initials: YE
authors.lastname: Joo
authors.forename: Tag
authors.initials: T
authors.lastname: Heo
authors.forename: Chang-Hwan
authors.initials: CH
authors.lastname: Park
authors.forename: Wan-Sik
authors.initials: WS
authors.lastname: Lee
authors.forename: Hyun-Soo
authors.initials: HS
authors.lastname: Kim
authors.forename: Jung-Chul
authors.initials: JC
authors.lastname: Kim
authors.forename: Yang-Seok
authors.initials: YS
authors.lastname: Koh
authors.forename: Sung-Kyu
authors.initials: SK
authors.lastname: Choi
authors.forename: Chol-Kyoon
authors.initials: CK
authors.lastname: Cho
authors.forename: Jong-Sun
authors.initials: JS
authors.lastname: Rew
authors.forename: Sei-Jong
authors.initials: SJ
authors.lastname: Kim
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D021441:Carcinoma, Pancreatic Ductal / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D003937:Diagnosis, Differential; D005260:Female; D005870:Giant Cell Tumors / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008854:Microscopy, Electron; D008875:Middle Aged; D018396:Mucin-1 / Q000032:analysis; D010010:Osteoclasts / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D014746:Vimentin / Q000032:analysis; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D007633:Keratins; D018396:Mucin-1; D018809:Proliferating Cell Nuclear Antigen; D014746:Vimentin; C067980:CD68 antigen, human; D000097382:CD68 Molecule