title: New horizons in orthopaedics: a rational discussion of biologics and bone graft substitutes.
abstract: Numerous inductive proteins, conductive substrates, and autogenous cellular concentration techniques have become clinically available as substitutes for autogenous bone graft. This review presents a critical analysis of their preclinical and clinical efficacy. In many instances, the widespread use of these materials must be questioned based on the limited clinical data available. A thorough knowledge of these materials is crucial for the surgeon to match the material to its defined indications.
authors.affiliation: Department of Orthopaedic Surgery, Division of Orthopaedic Traumatology, Saint Louis University School of Medicine, USA.
authors.forename: J Tracy
authors.initials: JT
authors.lastname: Watson
mesh_terms: D001672:Biocompatible Materials / Q000627:therapeutic use; D001688:Biological Products / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation / Q000379:methods; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods*; D017102:Fracture Healing / Q000187:drug effects*; D006801:Humans; D017713:Platelet Transfusion / Q000379:methods
chemical_list: D001672:Biocompatible Materials; D001688:Biological Products; D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes