[Effects of gastric bypass on weight, blood glucose, serum lipid levels and arterial blood pressure in obese patients].
BACKGROUND
Type 2 diabetes, hypertension and serum lipid abnormalities are common among obese people and they should improve with weight reduction.


OBJECTIVE
To study the outcome of these abnormalities after bariatric surgery in morbid obesity patients.


METHODS
Two hundred thirty two morbid obese patients subjected to gastric bypass, were evaluated in the preoperative period and every three months after surgery, during a minimum of 12 months. Clinical evolution, blood glucose, serum insulin, insulin resistance measured with the homeostasis model assessment (HOMA) and serum lipid levels were analyzed.


RESULTS
In the preoperative period, 17% had type 2 diabetes, 49% had abnormal serum lipid levels and 25% had high blood pressure. Sixty six percent had at least one of these abnormalities and 20% had more than one. During follow up, body mass index decreased from 44 to 29.3 kg/m2. Total and HDL cholesterol, blood glucose and insulin resistance significantly decreased from the third month after surgery. Diabetes disappeared in 97% of diabetic subjects, blood pressure normalized in 53% of subjects with hypertension and serum lipid levels returned to normal in 88% of subjects with dyslipidemia.


CONCLUSIONS
Gastric bypass in morbid obese patients achieves a significant and important weight reduction that results in significant reductions in the frequency of diabetes, dyslipidemia and hypertension among operated obese subjects.
Papapietro
Karin
K
Departamento de Cirugía, Unidad de Nutrición, Hospital Clínico, Universidad de Chile, Santiago, Chile.
Díaz
Emma
E
Csendes
Attila
A
Díaz
Juan Carlos
JC
Braghetto
Italo
I
Burdiles
Patricio
P
Maluenda
Fernando
F
Rojas
Jorge
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose; D001794:Blood Pressure; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000601:surgery; D050171:Dyslipidemias / Q000378:metabolism* / Q000601:surgery; D005260:Female; D015390:Gastric Bypass; D006801:Humans; D006973:Hypertension / Q000378:metabolism* / Q000601:surgery; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000378:metabolism* / Q000601:surgery; D011446:Prospective Studies; D015431:Weight Loss
D001786:Blood Glucose; D008055:Lipids