title: Linezolid-induced optic neuropathy.
abstract: OBJECTIVE
  To report a case of optic neuropathy associated with prolonged use of a new antibiotic, linezolid.
  
  
  METHODS
  Interventional case report.
  
  
  METHODS
  Optic and peripheral neuropathy occurred in a 27-year-old woman who was undergoing prolonged linezolid therapy for osteomyelitis. The use of corticosteroid exacerbated visual loss. Discontinuation of the linezolid therapy resulted in marked improvement of optic neuropathy.
  
  
  RESULTS
  Linezolid-induced optic neuropathy was diagnosed in this case, because prolonged linezolid therapy was performed at a higher dose than usual and because the patient recovered after linezolid therapy was discontinued.
  
  
  CONCLUSIONS
  With prolonged linezolid therapy, ophthalmologists should be aware that bilateral optic neuropathy can occur and that corticosteroids are not indicated for this neuropathy.
authors.affiliation: Department of Ophthalmology, Tokyo University School of Medicine, and Kawakita General Hospital, 1-7-3 Asagayakita, Suginami, Tokyo 166-8658, Japan. paul@d4.dion.ne.jp
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Saijo
authors.forename: Keiko
authors.initials: K
authors.lastname: Hayashi
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Yamada
authors.forename: Masato
authors.initials: M
authors.lastname: Wakakura
mesh_terms: D000081:Acetamides / Q000009:adverse effects*; D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D000069349:Linezolid; D009901:Optic Nerve Diseases / Q000139:chemically induced*; D023303:Oxazolidinones / Q000009:adverse effects*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid