title: Identification of aminopiperidine benzamides as MCHr1 antagonists.
abstract: The identification of a novel series of benzamide-containing MCHr1 antagonists is described. Compound 22 displayed moderate efficacy in a diet induced obesity mice model.
authors.affiliation: Metabolic Diseases Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA. anil.vasudevan@abbott.com
authors.forename: Anil
authors.initials: A
authors.lastname: Vasudevan
authors.forename: Mary K
authors.initials: MK
authors.lastname: Verzal
authors.forename: Derek
authors.initials: D
authors.lastname: Wodka
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Souers
authors.forename: Christopher
authors.initials: C
authors.lastname: Blackburn
authors.forename: Jennifer Lee
authors.initials: JL
authors.lastname: Che
authors.forename: Sujen
authors.initials: S
authors.lastname: Lai
authors.forename: Sevan
authors.initials: S
authors.lastname: Brodjian
authors.forename: Doug H
authors.initials: DH
authors.lastname: Falls
authors.forename: Brian D
authors.initials: BD
authors.lastname: Dayton
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Govek
authors.forename: Tom
authors.initials: T
authors.lastname: Daniels
authors.forename: Brad
authors.initials: B
authors.lastname: Geddes
authors.forename: Kennan C
authors.initials: KC
authors.lastname: Marsh
authors.forename: Lisa E
authors.initials: LE
authors.lastname: Hernandez
authors.forename: Christine A
authors.initials: CA
authors.lastname: Collins
authors.forename: Philip R
authors.initials: PR
authors.lastname: Kym
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019440:Anti-Obesity Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001549:Benzamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001667:Binding, Competitive; D004195:Disease Models, Animal; D004285:Dogs; D051379:Mice; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D017481:Receptors, Somatostatin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship; D013997:Time Factors
chemical_list: D019440:Anti-Obesity Agents; D001549:Benzamides; D010880:Piperidines; D017481:Receptors, Somatostatin