5-HT 1A polymorphism and self-transcendence in mood disorders.
Recently, an association between serotonin 1A receptor binding potential and self-transcendence scores at the temperament and character inventory (TCI) has been reported. We tested involvement of 5-HT(1A) gene in this trait, in a sample of 40 remitted mood disorder patients. Subjects with the 5-HT(1A)*C/C genotype showed significantly lower scores at the total self-transcendence and at the sub-scales of transpersonal identification and spiritual acceptance. Our preliminary results further support the involvement of the serotoninergic pattern in the self-transcendence character trait.
Lorenzi
Cristina
C
Department of Psychiatry P. Ottonello Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Serretti
Alessandro
A
Mandelli
Laura
L
Tubazio
Viviana
V
Ploia
Cristina
C
Smeraldi
Enrico
E
D000328:Adult; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000235:genetics* / Q000523:psychology; D011110:Polymorphism, Genetic; D011569:Psychiatric Status Rating Scales; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics*; D012649:Self Concept
D044282:Receptor, Serotonin, 5-HT1A