title: Design and simulation of active biochip system.
abstract: To solve the problems existing in passive biochip systems, we designed a novel active biochip system. This system introduces negative pressure and controlling devices to adjust the antigen-antibody reaction on the nitrocellulose membrane. Computational simulation demonstrated that this system is a rapid, stable, robust and practical system that may enhance the efficiency of antigen-antibody reactions and improve the repeatability and accuracy of biochip analysis.
authors.affiliation: Institute of Genetic Diagnosis, The Fourth Military Medical University, Xi'an 710032, PR China. zhuwenwei428@hotmail.com
authors.forename: Wenwei
authors.initials: W
authors.lastname: Zhu
authors.forename: Wenbiao
authors.initials: W
authors.lastname: Zhu
authors.forename: Wenhong
authors.initials: W
authors.lastname: Zhang
authors.forename: Fengchan
authors.initials: F
authors.lastname: Han
authors.forename: Xiuzhen
authors.initials: X
authors.lastname: Dong
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Yan
mesh_terms: D000936:Antigen-Antibody Complex / Q000032:analysis*; D001681:Biological Assay / Q000295:instrumentation* / Q000379:methods; D003198:Computer Simulation; D017076:Computer-Aided Design; D004867:Equipment Design / Q000379:methods*; D019544:Equipment Failure Analysis / Q000379:methods; D017022:Flow Injection Analysis / Q000295:instrumentation* / Q000379:methods; D007118:Immunoassay / Q000295:instrumentation* / Q000379:methods; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods; D008962:Models, Theoretical; D040081:Protein Array Analysis / Q000295:instrumentation* / Q000379:methods
chemical_list: D000936:Antigen-Antibody Complex