[Glottic laryngeal carcinoma. Tis, T1 and T2--long term results after laser resection].
BACKGROUND
Endoscopic laser resection is one treatment modality for early glottic carcinoma. Benefits are the preservation of laryngeal structure without tracheotomy, the short duration of treatment, low traumatisation and good functional results.


METHODS
From 1989 to 1999, 143 patients with an isolated and previously untreated glottic squamous cell carcinoma were treated by CO2 endoscopic laser resection. The tumors were classified as carcinoma in situ (Tis) in seven cases, T1 tumor (T1N0M0) in 91 patients and T2 tumor (T2N0M0) in 45 cases. Median follow-up was 5 years.


RESULTS
For the group of Tis and T1 carcinomas, 86 of 98 patients were free of recurrences. The 12 recurrences (12.2%) were treated by repeated laser surgery and laryngectomy (four patients). None of these patients died of tumor related causes. For patients with T2 carcinomas, the overall recurrence rate was 28.9% (13 patients). In six patients, a total laryngectomy had to be performed and one patient died because of tumor recurrence. The relapse free survival estimate using the Kaplan-Meier method was 87% for Tis and T1 carcinomas and 70% for T2 carcinomas. The overall laryngeal preservation rate was 95% for Tis and T1 carcinomas and 85% for T2 tumors. All recurrences occurred within 4 years of primary surgery.


CONCLUSIONS
The results suggest that the oncological outcome after endoscopic laser surgery is comparable to conventional open partial resections.
König
O
O
Klinik für Audiologie und Phoniatrie der Charité--Universitätsmedizin Berlin, Campus Benjamin Franklin. ovidiu.koenig@charite.de
Bockmühl
U
U
Haake
K
K
D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000601:surgery*; D004724:Endoscopy / Q000706:statistics & numerical data*; D005260:Female; D005858:Germany / Q000453:epidemiology; D005931:Glottis / Q000601:surgery*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000453:epidemiology* / Q000601:surgery*; D053685:Laser Therapy / Q000706:statistics & numerical data*; D008137:Longitudinal Studies; D008297:Male; D008866:Microsurgery / Q000706:statistics & numerical data; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome