title: Intralesional injection of Tisseel fibrin glue for resection of lymphangiomas and other thin-walled orbital cysts.
abstract: OBJECTIVE
  Surgical removal of orbital lymphangiomas is often difficult because the capsule of these lesions is fragile, and, once violated, it tends to collapse, making identification of residual tumor difficult and dissection often incomplete. A surgical technique combining partial controlled decompression of the lesion with intralesional injection of Tisseel fibrin glue is evaluated to determine its effectiveness in resecting the lesion and preventing recurrences.
  
  
  METHODS
  This is a retrospective interventional case series. Three young patients, two with lymphangiomas and one with congenital hydrocystoma, underwent surgical resection of their thin-walled cystic lesions of the orbit with the use of intralesional injection of Tisseel fibrin glue. Resolution of the signs and symptoms, complications of the surgery, and recurrence of bleeding are the parameters studied.
  
  
  RESULTS
  All 3 patients had improvement of their signs and symptoms. None had complications related to the surgery, and no recurrence of bleeding occurred during the follow-up period.
  
  
  CONCLUSIONS
  Our study suggests that this surgical technique with intralesional injection of Tisseel fibrin glue is an effective treatment modality for the resection of lymphangiomas and other orbital thin-walled cystic lesions.
authors.affiliation: Sainte-Justine Hospital, Montréal, Québec, Canada.
authors.forename: Patrick R
authors.initials: PR
authors.lastname: Boulos
authors.forename: Mona
authors.initials: M
authors.lastname: Harissi-Dagher
authors.forename: Conrad
authors.initials: C
authors.lastname: Kavalec
authors.forename: Isabelle
authors.initials: I
authors.lastname: Hardy
authors.forename: François
authors.initials: F
authors.lastname: Codère
mesh_terms: D016063:Blood Loss, Surgical / Q000517:prevention & control; D002675:Child, Preschool; D003560:Cysts / Q000601:surgery*; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D015552:Injections, Intralesional; D007431:Intraoperative Complications / Q000517:prevention & control; D008202:Lymphangioma / Q000601:surgery*; D008297:Male; D009916:Orbital Diseases / Q000601:surgery*; D009918:Orbital Neoplasms / Q000601:surgery*; D012189:Retrospective Studies; D014014:Tissue Adhesives / Q000008:administration & dosage*
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives