title: A new structural alternative in benzo[b]furans for antimicrobial activity.
abstract: Two series of 2-substituted and three new diacetyl benzofurans were synthesized through palladium-catalyzed reactions and their in vitro antimicrobial spectra were assessed. The compounds demonstrated mild to significant growth inhibition against antibiotic-susceptible standard and clinically isolated strains of Gram-positive and Gram-negative bacteria as well as human fungal pathogens. Ampicillin and kanamycin were used as references for antibacterial screening; nystatin and amphotericin B were used for antifungal screening. Varying substitution at the benzofuran moiety and subsequent antimicrobial screening identified the C-3-acetyl functionality as a new structural alternative for optimal antimicrobial property in the benzofuran class of compounds.
authors.affiliation: Department of Chemistry, Bangladesh University of Engineering and Technology, Dhaka 1000, Bangladesh.
authors.forename: M
authors.initials: M
authors.lastname: Wahab Khan
authors.forename: M
authors.initials: M
authors.lastname: Jahangir Alam
authors.forename: M A
authors.initials: MA
authors.lastname: Rashid
authors.forename: R
authors.initials: R
authors.lastname: Chowdhury
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001572:Benzofurans / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D001572:Benzofurans