[Advances in the research of human defensins].
Human defensin is a family of cationic antimicrobial peptides in human being. During the last two decades a series of endogenous alpha-and beta-human defensins have been discovered. They are important components of the first barrier in human's body against the invasion of various microorganisms, and they are thought to play an important role in linking the innate and adaptive defense system of human being. The recent advances in the research of human defensins were reviewed, including their discovery, molecular and genetic properties, expression regulation, and mechanisms of antimicrobial activity. The possibility to produce human defensins via genetic engineering was also discussed. And the application outlook of human defensins in medicine and curing patients infected with antibiotics-resistant microbials was presented.
Peng
Li
L
Institute of Bioengineering, Zhejiang University, Hangzhou 310027, China.
Xu
Zhi-Nan
ZN
Fang
Xiang-Ming
XM
Qu
Jin-Min
JM
Cen
Pei-Lin
PL
D000595:Amino Acid Sequence; D023082:Defensins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D005818:Genetic Engineering; D006801:Humans; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid
D023082:Defensins