title: Molecular characterization of virulent Newcastle disease virus isolates from chickens during the 1998 NDV outbreak in Kazakhstan.
abstract: Newcastle disease virus (NDV) infects domesticated and wild birds throughout the world and has the possibility to cause outbreaks in chicken flocks in future. To assess the evolutionary characteristics of 10 NDV strains isolated from chickens in Kazakhstan during 1998 we investigated the phylogenetic relationships among these viruses and viruses described previously. For genotyping, fusion (F) gene phylogenetic analysis (nucleotide number 47-421) was performed using sequences of Kazakhstanian isolates as compared to sequences of selected NDV strains from GenBank. Phylogenetic analysis showed that all newly characterized strains belonged to the genetic group designated as VIIb. All strains possessed a virulent fusion cleavage site (RRQRR/F) belonging to velogenic or mesogenic pathotypes with intracerebral pathogenicity indexes (ICPI) varying from 1.05 to 1.87.
authors.affiliation: Institute of Microbiology & Virology, Bogenbay batyr Street, 103, 480100, Almaty, Kazakhstan.
authors.forename: Andrey
authors.initials: A
authors.lastname: Bogoyavlenskiy
authors.forename: Vladimir
authors.initials: V
authors.lastname: Berezin
authors.forename: Alexey
authors.initials: A
authors.lastname: Prilipov
authors.forename: Eugeniy
authors.initials: E
authors.lastname: Usachev
authors.forename: Olga
authors.initials: O
authors.lastname: Lyapina
authors.forename: Svetlana
authors.initials: S
authors.lastname: Levandovskaya
authors.forename: Ilya
authors.initials: I
authors.lastname: Korotetskiy
authors.forename: Valentina
authors.initials: V
authors.lastname: Tolmacheva
authors.forename: Nailya
authors.initials: N
authors.lastname: Makhmudova
authors.forename: Svetlana
authors.initials: S
authors.lastname: Khudyakova
authors.forename: Gulnur
authors.initials: G
authors.lastname: Tustikbaeva
authors.forename: Irina
authors.initials: I
authors.lastname: Zaitseva
authors.forename: Elmira
authors.initials: E
authors.lastname: Omirtaeva
authors.forename: Olga
authors.initials: O
authors.lastname: Ermakova
authors.forename: Klara
authors.initials: K
authors.lastname: Daulbaeva
authors.forename: Saule
authors.initials: S
authors.lastname: Asanova
authors.forename: Aydyn
authors.initials: A
authors.lastname: Kydyrmanov
authors.forename: Marat
authors.initials: M
authors.lastname: Sayatov
authors.forename: Daniel
authors.initials: D
authors.lastname: King
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002645:Chickens; D004196:Disease Outbreaks / Q000662:veterinary*; D005838:Genotype; D007623:Kazakhstan / Q000453:epidemiology; D008969:Molecular Sequence Data; D009521:Newcastle Disease / Q000453:epidemiology / Q000821:virology*; D009522:Newcastle disease virus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification* / Q000472:pathogenicity; D010802:Phylogeny; D011201:Poultry Diseases / Q000453:epidemiology / Q000821:virology*; D016415:Sequence Alignment; D014760:Viral Fusion Proteins / Q000235:genetics; D014774:Virulence
chemical_list: D014760:Viral Fusion Proteins