title: An extract from teak (Tectona grandis) bark inhibited Listeria monocytogenes and methicillin resistant Staphylococcus aureus.
abstract: OBJECTIVE
  The aim of this study was to characterize the inhibitory mechanism in teak (Tectona grandis) bark and to determine its effectiveness against Listeria monocytogenes and methicillin resistant Staphylococcus aureus (MRSA).
  
  
  RESULTS
  Methanol extracts of teak bark were inhibitory to L. monocytogenes and MRSA by means of disc diffusion. Gas chromatography-mass spectrometry, and (1)H and (13)C nuclear mass resonance analyses revealed that the inhibitory compound had a molecular weight of 174, and a structure of 5-hydroxy-1,4-naphthalenedione (Juglone).
  
  
  CONCLUSIONS
  5-hydroxy-1,4-naphthalenedione (Juglone) inhibited L. monocytogenes and MRSA.
  
  
  CONCLUSIONS
  A compound in an extract of teak bark was inhibitory to L. monocytogenes and MRSA.
authors.affiliation: School of Life Sciences, Heriot-Watt University, Edinburgh, UK.
authors.forename: A
authors.initials: A
authors.lastname: Neamatallah
authors.forename: L
authors.initials: L
authors.lastname: Yan
authors.forename: S J
authors.initials: SJ
authors.lastname: Dewar
authors.forename: B
authors.initials: B
authors.lastname: Austin
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D008401:Gas Chromatography-Mass Spectrometry; D008089:Listeria monocytogenes / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol; D016106:Methicillin Resistance / Q000235:genetics; D008970:Molecular Weight; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification*; D010860:Pigments, Biological / Q000737:chemistry / Q000302:isolation & purification*; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics; D029648:Verbenaceae / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D009285:Naphthoquinones; D010860:Pigments, Biological; D010936:Plant Extracts; C005134:juglone; D000432:Methanol