title: Premature rupture of membranes with oligo- or anhydramnios before 24 weeks of gestation and the chances of fetal survival.
abstract: Rupture of the membranes before the fetus has achieved viability within the womb is an event of enormous importance for both mother and physician. The potential outcome ranges from fetal death, a frequent occurrence, to a severely disabled life or a happy (but rare) birth without any mental or physical retardation for the child. The aim of the present investigation was to provide the consulting physician with valid data, enabling him/her to make a realistic assessment of the risks and to inform the patient accordingly.
  
  
  METHODS
  In a retrospective analysis, we followed 36 cases with spontaneous rupture of the maternal membranes and development of oligo-/anhydramnios before 24 weeks of gestation. The patients had been treated between January 1994 and 2004. In a more detailed assessment, the patient cohort was divided into one group of women with rupture between 10 and 20 weeks of gestation and another group with a gestational age between start of week 21 and end of week 23.
  
  
  RESULTS
  Of the 36 children, seven (19.4%) survived initially, with two of the seven survivors dying subsequently. Among women with amniorrhexis before week 21 of gestation, only three of the 26 children survived, while four of 10 children survived among women with premature rupture of membranes between 21 and 23 weeks of gestation (p = 0.053) No case of mental retardation could be observed in the surviving children. Perinatal outcome was found to be significantly different in the presence of amnionitis (3/27) compared to the group without this event (4/9) (p = 0.028).
  
  
  CONCLUSIONS
  Because of the poor fetal outcome, termination of an ongoing pregnancy must also be considered in counseling the mother. If the mother decides to continue her pregnancy, amnionitis will be the most critical factor for ultimate termination of pregnancy.
authors.affiliation: Abteilung Geburtshilfe, Landesfrauenklinik Linz, Linz, Austria. Gernot.Tews@gespag.at
authors.forename: Gernot
authors.initials: G
authors.lastname: Tews
authors.forename: Omar
authors.initials: O
authors.lastname: Shebl
authors.forename: Thomas
authors.initials: T
authors.lastname: Ebner
authors.forename: Michael
authors.initials: M
authors.lastname: Sommergruber
authors.forename: Klaus
authors.initials: K
authors.lastname: Jesacher
mesh_terms: D001317:Austria; D002821:Chorioamnionitis / Q000175:diagnosis / Q000401:mortality; D015331:Cohort Studies; D005260:Female; D005313:Fetal Death / Q000209:etiology*; D005322:Premature Rupture of Fetal Membranes / Q000175:diagnosis* / Q000401:mortality; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D016104:Oligohydramnios / Q000175:diagnosis* / Q000401:mortality; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D012307:Risk Factors; D015996:Survival Rate