title: Platelet function disorder in Gardner-Diamond syndrome: a case report and review of the literature.
abstract: The Gardner-Diamond syndrome is a disorder characterized by recurrent spontaneous painful bruising in patients with underlying psychosis and neurosis. Despite the presence of other symptoms suggestive of an underlying disorder of primary hemostasis in a large percentage of reported patients, results of testing for von Willebrand disease or platelet function disorders are lacking. The authors describe a case of Gardner-Diamond syndrome in an adolescent girl who had abnormal platelet responses during platelet aggregation studies. A review of the literature revealed only three additional patients with Gardner-Diamond syndrome who have had platelet aggregation studies reported. To date, all patients with Gardner-Diamond syndrome reported to have undergone platelet aggregation studies have had abnormal results.
authors.affiliation: Division of Hemostasis, Department of Pediatrics, St. Louis University Health Sciences Center, Cardinal Glennon Children's Hospital, 1465 S. Grand, St. Louis, MO, USA. puetzjj@slu.edu
authors.forename: John
authors.initials: J
authors.lastname: Puetz
authors.forename: Timothy
authors.initials: T
authors.lastname: Fete
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000293:Adolescent; D016718:Arachidonic Acid / Q000494:pharmacology; D001778:Blood Coagulation Disorders / Q000097:blood*; D001791:Blood Platelet Disorders / Q000097:blood*; D003288:Contusions; D005260:Female; D005736:Gardner Syndrome / Q000097:blood*; D006801:Humans; D001523:Mental Disorders; D010974:Platelet Aggregation / Q000187:drug effects; D011618:Psychotic Disorders; D013577:Syndrome
chemical_list: D016718:Arachidonic Acid; D000244:Adenosine Diphosphate