Chiral quantification of D-, L-phenylglycine mixture using mass spectrometric kinetic method.
A novel mass spectrometric method is applied to rapid, accurate, quantitative analysis of chiral phenylglycine. Transition-metal-bound complex ions containing the chiral phenylglycine are generated by electrospray ionization mass spectrometry and subjected to collision-induced dissociation. The ratio of the two competitive dissociation rates is related to the enantiomeric composition of the mixture, allowing the determination of enantiomeric contamination in the intermediates.
Ming
Li
L
College of Chemistry, Institute of Miniature Analytical Instrumentation, Jilin Province Research Center for Engineering and Technology of Spectral Instruments, Jilin University, Changchun 130021, China.
Zhiqiang
Liu
L
Huanwen
Chen
C
Shuying
Liu
L
Qinhan
Jin
J
D005998:Glycine / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry; D007700:Kinetics; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D013237:Stereoisomerism
C027797:phenylglycine chloride; D005998:Glycine