title: Preoperative chemoradiotherapy in locally advanced rectal cancer: Ramathibodi experience.
abstract: A retrospective study of the preoperative chemoradiotherapy in locally advanced rectal cancer performed at Ramathibodi Hospital. The median age of twelve patients was 52 years. The tumor locations (upper-, mid-, lower rectum) were 25%, 50% and 25%, respectively. Eleven patients had clinical stage 111 disease. All received concurrent 5-FU-based chemoradiotherapy followed by surgery (if resectable) and chemotherapy. The most common toxicity of preoperative treatment was gr. 1-2 diarrhea (58.3%). The response rate was 41.7%. Five patients (41.7%) underwent sphincter-sparing surgery. Four patients underwent AP resection. Twenty-five percent achieved pathological complete response. Pathological downstaging occurred in 33.3%. The remaining three patients had unresectable disease. With the median follow up of 13 months, five patients had progressive disease and one has expired. The local failure rate was 16.7%. The one-year recurrence-free survival was 75%. The authors conclude that preoperative chemoradiotherapy is an effective treatment with favorable outcome in locally advanced rectal cancer.
authors.affiliation: Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
authors.forename: Ekaphop
authors.initials: E
authors.lastname: Sirachainan
authors.forename: Kanit
authors.initials: K
authors.lastname: Sumboonnanonda
authors.forename: Somjai
authors.initials: S
authors.lastname: Dangprasert
authors.forename: Ravat
authors.initials: R
authors.lastname: Panvichian
authors.forename: Thitiya
authors.initials: T
authors.lastname: Sirisinha
authors.forename: Mantana
authors.initials: M
authors.lastname: Dhanachai
authors.forename: Virat
authors.initials: V
authors.lastname: Pairachvet
authors.forename: Puangtong
authors.initials: P
authors.lastname: Kraiphibul
authors.forename: Vorachai
authors.initials: V
authors.lastname: Ratanatharathorn
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003082:Colectomy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D011300:Preoperative Care; D018714:Radiotherapy, Adjuvant; D012004:Rectal Neoplasms / Q000473:pathology / Q000628:therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents