Synthesis of 2,5- and 3,5-diphenylpyridine derivatives for DNA recognition and cytotoxicity.
A series of 2,5- and 3,5-diphenylpyridine derivatives was synthetised in high yields. A versatile chemical strategy allows the design of diphenylpyridines differently substituted with cationic or neutral side chains. The interaction of the molecules with DNA was investigated by biophysical and biochemical methods and an AT-binder (20) was characterised. A few cytotoxic molecules were identified but their antiproliferative activity does not correlate with DNA binding. Two compounds 18 and 22 showed significant antiproliferative activity and provide a novel route to potential anticancer agents.
Jacquemard
Ulrich
U
Institut de Chimie Organique et Analytique, UMR 6005, Université d'Orléans, B.P. 6759, 45067 Orléans cedex 2, France.
Routier
Sylvain
S
Dias
Nathalie
N
Lansiaux
Amélie
A
Goossens
Jean-François
JF
Bailly
Christian
C
Mérour
Jean-Yves
JY
D004247:DNA / Q000378:metabolism*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007364:Intercalating Agents / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D007364:Intercalating Agents; D011725:Pyridines; D004247:DNA