title: Changes in platelet aggregation during cardiopulmonary bypass: comparison of poly-2-methoxyethylacrylate and heparin as a circuit coating material.
abstract: At present, there are various biomaterials that have high biocompatibility. In particular, there are many types of coated circuits in cardiopulmonary bypass (CPB) systems. However, only a few clinical studies have investigated platelet aggregation caused by these coated circuits. In this study, a CPB system coated with poly-2-methoxyethylacrylate (X coating) was used to ascertain whether platelet aggregation could be suppressed during CPB, and a comparison was made between X coating and ordinary (covalently bonded) heparin coating. The subjects were 19 adult patients who were scheduled to undergo valve replacement or valvuloplasty. They were divided into two groups: group X (X coating) and group H (heparin coating). The platelet aggregation threshold index (PATI, grading curve) and beta-thromboglobulin and plalelet factor IV levels were assessed preoperatively (control), 5 min after heparin administration, 10 and 60 min after the start of CPB, and 0 and 2 h after the end of CPB. The results indicated that platelet aggregation was reduced during CPB and that platelets were activated. The changes in platelet aggregation associated with the X coating were shown to be similar to those associated with heparin coating.
authors.affiliation: Division of Surgery, Fukushima Medical University Hospital, 1-Hikarigaoka, Fukushima, 960-1295, Japan. h-izuha@fmu.ac.jp
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Izuha
authors.forename: Momoe
authors.initials: M
authors.lastname: Hattori
authors.forename: Tsuguo
authors.initials: T
authors.lastname: Igari
authors.forename: Daiki
authors.initials: D
authors.lastname: Wakamatsu
authors.forename: Mdtoshiki
authors.initials: M
authors.lastname: Watanabe
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yokoyama
mesh_terms: D000179:Acrylates; D000328:Adult; D000368:Aged; D002315:Cardiopulmonary Bypass; D020099:Coated Materials, Biocompatible; D005260:Female; D006493:Heparin; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D010978:Platelet Factor 4 / Q000032:analysis; D011108:Polymers; D001620:beta-Thromboglobulin / Q000032:analysis
chemical_list: D000179:Acrylates; D020099:Coated Materials, Biocompatible; D011108:Polymers; D001620:beta-Thromboglobulin; C413485:poly(2-methoxyethylacrylate); D010978:Platelet Factor 4; D006493:Heparin