title: Cardiovascular stent design and vessel stresses: a finite element analysis.
abstract: Intravascular stents of various designs are currently in use to restore patency in atherosclerotic coronary arteries and it has been found that different stents have different in-stent restenosis rates. It has been hypothesized that the level of vascular injury caused to a vessel by a stent determines the level of restenosis. Computational studies may be used to investigate the mechanical behaviour of stents and to determine the biomechanical interaction between the stent and the artery in a stenting procedure. In this paper, we test the hypothesis that two different stent designs will provoke different levels of stress within an atherosclerotic artery and hence cause different levels of vascular injury. The stents analysed using the finite-element method were the S7 (Medtronic AVE) and the NIR (Boston Scientific) stent designs. An analysis of the arterial wall stresses in the stented arteries indicates that the modular S7 stent design causes lower stress to an atherosclerotic vessel with a localized stenotic lesion compared to the slotted tube NIR design. These results correlate with observed clinical restenosis rates, which have found higher restenosis rates in the NIR compared with the S7 stent design. Therefore, the testing methodology outlined here is proposed as a pre-clinical testing tool, which could be used to compare and contrast existing stent designs and to develop novel stent designs.
authors.affiliation: Centre for Bioengineering, Department of Mechanical Engineering, Trinity College, Dublin 2, Ireland.
authors.forename: C
authors.initials: C
authors.lastname: Lally
authors.forename: F
authors.initials: F
authors.lastname: Dolan
authors.forename: P J
authors.initials: PJ
authors.lastname: Prendergast
mesh_terms: D001807:Blood Vessel Prosthesis; D003198:Computer Simulation; D017076:Computer-Aided Design; D003324:Coronary Artery Disease / Q000503:physiopathology* / Q000601:surgery*; D003331:Coronary Vessels / Q000503:physiopathology / Q000601:surgery; D019544:Equipment Failure Analysis / Q000379:methods; D020342:Finite Element Analysis; D006801:Humans; D008955:Models, Cardiovascular; D011474:Prosthesis Design / Q000379:methods; D015607:Stents; D013314:Stress, Mechanical