title: First-trimester screening for fetal triploidy at 11 to 14 weeks: a role for fetal biometry.
abstract: OBJECTIVE
  Intrauterine growth restriction in triploidy has been reported as early as in the first trimester. This study was undertaken to evaluate the ability of first-trimester crown rump length (CRL)-based charts to detect triploid fetuses.
  
  
  METHODS
  Analysis of fetal biometry in cases of triploidy diagnosed in the first trimester over the last three years. Biometry for abdominal circumference (AC), head circumference (HC) and biparietal diameter (BPD) was analyzed in relation to both gestational age (GA)-based charts and to CRL-based charts.
  
  
  RESULTS
  Five cases of fetal triploidy were diagnosed at 11 to 14 weeks. Screening based on nuchal translucency (NT) and maternal age showed a risk > 1/300 in only one of the 5 cases of triploid fetus. In all of these five cases, CRL-based biometry was grossly abnormal, although it was abnormal in only two of these five cases in relation to GA-based charts.
  
  
  CONCLUSIONS
  First-trimester CRL-based biometry charts seem to reflect early asymmetrical growth delay in triploidy more accurately than GA-based charts. CRL-based biometry is likely to improve the early detection of triploid pregnancies without leading to dating error.
authors.affiliation: Service de Gynécologie-Obstétrique, Centre Hospitalier Intercommunal de Poissy-St Germain, 10 rue Champ Gaillard, Poissy, France.
authors.forename: L J
authors.initials: LJ
authors.lastname: Salomon
authors.forename: J P
authors.initials: JP
authors.lastname: Bernard
authors.forename: J
authors.initials: J
authors.lastname: Nizard
authors.forename: Y
authors.initials: Y
authors.lastname: Ville
mesh_terms: D000005:Abdomen / Q000196:embryology; D000328:Adult; D001699:Biometry; D015193:Chorionic Villi Sampling; D018568:Crown-Rump Length; D005260:Female; D005865:Gestational Age; D006257:Head / Q000196:embryology; D006801:Humans; D008423:Maternal Age; D048208:Nuchal Translucency Measurement; D010296:Parietal Lobe / Q000196:embryology; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D014314:Trisomy / Q000175:diagnosis*; D016216:Ultrasonography, Prenatal