title: Chemokines in tumor progression and metastasis.
abstract: Although chemokines have been thought of primarily as leukocyte attractants, a growing body of evidence indicates that they also contribute to a number of tumor-related processes, such as tumor cell growth, angiogenesis/angiostasis, local invasion, and metastasis. The current knowledge of the possible involvement of chemokines and their receptors in these cellular events are reviewed here. The operating mechanism of chemokines in relation to metastatic processes in vivo are also discussed.
authors.affiliation: Laboratory of Immunodynamics, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, 2-2, Suita, 565-0871, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Tanaka
authors.forename: Zhongbin
authors.initials: Z
authors.lastname: Bai
authors.forename: Yuttana
authors.initials: Y
authors.lastname: Srinoulprasert
authors.forename: Bo-Gie
authors.initials: BG
authors.lastname: Yang
authors.forename: Bogi
authors.initials: B
authors.lastname: Yang
authors.forename: Haruko
authors.initials: H
authors.lastname: Hayasaka
authors.forename: Masayuki
authors.initials: M
authors.lastname: Miyasaka
mesh_terms: D002470:Cell Survival; D018925:Chemokines / Q000502:physiology*; D018450:Disease Progression; D006801:Humans; D009362:Neoplasm Metastasis / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology* / Q000503:physiopathology*; D009389:Neovascularization, Pathologic; D019707:Receptors, Chemokine / Q000502:physiology*
chemical_list: D018925:Chemokines; D019707:Receptors, Chemokine