A modular design of ruthenium catalysts with diamine and BINOL-derived phosphinite ligands that are enantiomerically-matched for the effective asymmetric transfer hydrogenation of simple ketones.
A method is reported for making a potentially very wide series of ruthenium hydrido chloro complexes with diamine and readily-prepared diphosphinite ligand modules as precatalysts for the asymmetric transfer hydrogenation of simple ketones to give chiral alcohols in good yield and enantioselectivity.
Guo
Rongwei
R
Department of Chemistry, University of Toronto, Ontario, Canada.
Elpelt
Christian
C
Chen
Xuanhua
X
Song
Datong
D
Morris
Robert H
RH
D000438:Alcohols / Q000138:chemical synthesis; D002384:Catalysis; D003959:Diamines / Q000737:chemistry*; D006865:Hydrogenation; D007659:Ketones / Q000737:chemistry*; D008024:Ligands; D010720:Phosphines / Q000737:chemistry*; D012428:Ruthenium; D013237:Stereoisomerism
D000438:Alcohols; D003959:Diamines; D007659:Ketones; D008024:Ligands; D010720:Phosphines; D012428:Ruthenium