Hemopressin: a novel bioactive peptide derived from the alpha1-chain of hemoglobin.
Hemopressin (PVNFKFLSH), a novel bioactive peptide derived from the alpha1-chain of hemoglobin, was originally isolated from rat brain homogenates. Hemopressin causes hypotension in anesthetized rats and is metabolized in vivo and in vitro by endopeptidase 24.15 (EP24.15), neurolysin (EP24.16), and angiotensin-converting enzyme (ACE). Hemopressin also exerts an antinociceptive action in experimental inflammatory hyperalgesia induced by carrageenin or bradykinin via a mechanism that is independent of opioids. These findings suggest that this peptide may have important regulatory physiological actions in vivo.
Dale
Camila Squarzoni
CS
Laboratório de Fisiopatologia, Instituto Butantan, São Paulo, SP 05503-900, Brasil. camisdale@butantan.gov.br
Pagano
Rosana de Lima
Rde L
Rioli
Vanessa
V
D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D006454:Hemoglobins / Q000302:isolation & purification / Q000494:pharmacology*; D006930:Hyperalgesia / Q000188:drug therapy*; D007022:Hypotension / Q000139:chemically induced*; D008297:Male; D010446:Peptide Fragments / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats
D000700:Analgesics; D006454:Hemoglobins; D010446:Peptide Fragments; C473218:hemopressin