title: Micelle-like nanoparticles of PLA-PEG-PLA triblock copolymer as chemotherapeutic carrier.
abstract: Triblock copolymer PLA-PEG-PLA were synthesized using ring opening polymerization with different LA/EG ratio. Micellar aggregates were prepared from these block copolymers and characterized. The degradation characteristics of selected copolymers were assessed in both micellar and film forms. Surface segregation of PEG was also quantified as a function of copolymer composition. Anti-cancer drugs 5-FU and paclitaxel were loaded into the micellar nanospheres with good efficiency. The drug release profile showed good control over the release of paclitaxel from these polymers.
authors.affiliation: School of Materials Science and Engineering, N4.1-1-30 Nanyang Avenue, Nanyang Technological University, Singapore 639798, Singapore.
authors.forename: Subbu S
authors.initials: SS
authors.lastname: Venkatraman
authors.forename: Pan
authors.initials: P
authors.lastname: Jie
authors.forename: Feng
authors.initials: F
authors.lastname: Min
authors.forename: Boey Yin Chiang
authors.initials: BY
authors.lastname: Freddy
authors.forename: Gan
authors.initials: G
authors.lastname: Leong-Huat
mesh_terms: D004337:Drug Carriers; D004355:Drug Stability; D007773:Lactates / Q000008:administration & dosage* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D049329:Nanostructures; D017239:Paclitaxel / Q000008:administration & dosage* / Q000737:chemistry; D010316:Particle Size; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility; D013499:Surface Properties
chemical_list: D004337:Drug Carriers; D007773:Lactates; D008823:Micelles; C088513:poly(lactic acid-ethylene glycol); D011092:Polyethylene Glycols; D017239:Paclitaxel