title: Two new non-glycosidic iridoids from the leaves of Campsis grandiflora.
abstract: Two new non-glycosidic iridoids, which were named cachinol (1) and 1-O-methyl cachinol (2), were isolated from the methanol extract of the leaves of Campsis grandiflora together with a known iridoid cachineside I (3). The structures of compounds 1 and 2 were determined on the basis of spectroscopic methods including two dimensional NMR and high resolution mass spectrometry. All of the isolated compounds showed mild inhibitory activities on rat platelet aggregation. Compounds 1 and 3 (IC50 : 246 and 219 microM, respectively) showed about 2-fold higher inhibitory effects than acetylsalicylic acid (ASA, IC50: 412 microM) on collagen-induced aggregation. Compounds 1 and 2 (IC50: 43.2 and 38.4 microM, respectively) were about 2-fold more inhibitory than ASA (IC50: 75.2 microM), and about 4-fold more effective than their glycoside 3 (IC50: 189 microM) on AA-induced aggregation.
authors.affiliation: Natural Products Research Institute, Seoul National University, Seoul, Korea.
authors.forename: Jing Ling
authors.initials: JL
authors.lastname: Jin
authors.forename: Sanghyun
authors.initials: S
authors.lastname: Lee
authors.forename: Yong Yook
authors.initials: YY
authors.lastname: Lee
authors.forename: Jung Eun
authors.initials: JE
authors.lastname: Heo
authors.forename: Jeong Mi
authors.initials: JM
authors.lastname: Kim
authors.forename: Hye Sook
authors.initials: HS
authors.lastname: Yun-Choi
mesh_terms: D000818:Animals; D029402:Bignoniaceae; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D039823:Iridoids / Q000737:chemistry / Q000494:pharmacology; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
chemical_list: D006027:Glycosides; D039823:Iridoids; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors