title: Radiofrequency thermal ablation of hepatocellular carcinoma: our five year experience.
abstract: OBJECTIVE
  We describe our experience in the multimodal treatment of HCC patients both using the PRFTA and IRFTA treatment associated or not with hepatic resection, valuating the feasibility, the complication, length of hospital stay and survival rate of selected HCC patients.
  
  
  METHODS
  Between March 1998 and January 2004, 53 HCC patients undergoing PRFTA and IRFTA treatment. We describe 41 patients with monofocal disease and 12 patients with multifocal disease: in this last group 7 patients had unilobar involvement while 5 patients had multilobar tumour.
  
  
  RESULTS
  We reported patients underwent RFTA because not candidates to surgical procedures and patients underwent liver resection and open radiofrequency treatment associated. We successfully used percutaneous and intraoperative approach being the last one significantly advantageous in lesions greater than 5 cm, multiple bilobar tumours and tumours close to the hilum and major vessels: the laparotomic approach permitted the temporary occlusion of the vascular inflow allowing Pringle manoeuvre.
  
  
  CONCLUSIONS
  Hepatocarcinoma still represent one of the major causes of cancer related death worldwide. Systemic therapeutic agents and locoregional agents are rarely correlated to complete response and usually associated to high toxicities: the potentially curative or palliative benefit of RFTA in non surgical candidates improve overall patients survival significally better then the chemotherapy regimens.
  
  
  CONCLUSIONS
  RFTA appears to have several advantages, which also include a reducing in morbidity, a shortening of the hospital stay and good response to patients requirement in term of enduring pain.
authors.affiliation: II Division of General Surgery, Department of Surgery, Santa Corona Hospital, Pietra Ligure-Savona, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Percivale
authors.forename: M
authors.initials: M
authors.lastname: Stella
authors.forename: G
authors.initials: G
authors.lastname: Barabino
authors.forename: M
authors.initials: M
authors.lastname: Pasqualini
authors.forename: R
authors.initials: R
authors.lastname: Pellicci
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000601:surgery*; D017115:Catheter Ablation / Q000009:adverse effects; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors