title: Nonhuman primate models of asthma.
abstract: Asthma is a complex human disease that does not have an accurate counterpart in any common model organism. Most of our understanding of the immune mechanisms underlying asthma comes from studies in man and mouse. However, there are fundamental differences between the spontaneous disease in man and the experimentally induced counterparts in mice. We advocate more extensive use of nonhuman primate asthma models to reconcile these differences between man and mouse.
authors.affiliation: Dynavax Technologies, Berkeley, CA 94710, USA. rcoffman@dvax.com
authors.forename: Robert L
authors.initials: RL
authors.lastname: Coffman
authors.forename: Edith M
authors.initials: EM
authors.lastname: Hessel
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology; D001249:Asthma / Q000276:immunology* / Q000503:physiopathology*; D004195:Disease Models, Animal; D000882:Haplorhini; D008168:Lung / Q000502:physiology; D051379:Mice; D013045:Species Specificity
chemical_list: D000906:Antibodies