Expression of Fgf and Tgfbeta signaling related genes during embryonic endochondral ossification.
Disturbed fibroblast growth factor (Fgf) and transforming growth factor beta (Tgfbeta) signaling lead to a variety of human skeletal disorders. To reveal the possible function and interaction of these signaling systems we have started to analyze the expression patterns of signaling factors, antagonists, receptors and transducers of these pathways in forelimbs of mouse embryos and compared them to the expression of established markers including Ihh. In addition to defining their expression domains in the developing bone, our study identified new subpopulations of chondrocytes characterized by the expression of distinct combinations of markers.
Minina
Eleonora
E
Otto Warburg-Laboratory, Max-Planck-Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany.
Schneider
Sabine
S
Rosowski
Mark
M
Lauster
Roland
R
Vortkamp
Andrea
A
D000818:Animals; D052004:Bone Morphogenetic Protein Receptors / Q000032:analysis / Q000235:genetics; D019485:Bone Morphogenetic Proteins / Q000032:analysis / Q000235:genetics; D019902:Chondrocytes / Q000737:chemistry / Q000378:metabolism; D004622:Embryo, Mammalian / Q000737:chemistry / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D005552:Forelimb / Q000737:chemistry / Q000196:embryology / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D007265:Inhibins / Q000032:analysis / Q000235:genetics; D051379:Mice; D010006:Osteoblasts / Q000737:chemistry / Q000378:metabolism; D010012:Osteogenesis / Q000235:genetics*; D017468:Receptors, Fibroblast Growth Factor / Q000032:analysis / Q000235:genetics; D018125:Receptors, Transforming Growth Factor beta / Q000032:analysis / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics; D016212:Transforming Growth Factor beta / Q000032:analysis / Q000235:genetics / Q000378:metabolism*
D019485:Bone Morphogenetic Proteins; D017468:Receptors, Fibroblast Growth Factor; D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta; D007265:Inhibins; D005346:Fibroblast Growth Factors; D052004:Bone Morphogenetic Protein Receptors