Anti-MuSK myasthenia gravis presenting with purely ocular findings.
BACKGROUND
Antibodies to a muscle-specific receptor tyrosine kinase (MuSK) have been found in approximately 40% of patients with generalized myasthenia gravis who are seronegative for the antiacetylcholine receptor antibody. Many of the patients with anti-MuSK antibodies have prominent oculobulbar symptoms or weakness of the neck and respiratory muscles, but patients with ocular myasthenia have not been described.


OBJECTIVE
To report a case of ocular myasthenia due to anti-MuSK antibodies.


METHODS
A young woman with ocular myasthenia and antibodies to MuSK.


RESULTS
Anti-MuSK antibody was detected by radioimmunoassay using highly purified MuSK recombinant antigen.


CONCLUSIONS
Ocular myasthenia gravis is a presentation of the anti-MuSK antibody syndrome.
Caress
James B
JB
Department of Neurology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. jcaress@wfubmc.edu
Hunt
Christopher H
CH
Batish
Sat Dev
SD
D000293:Adolescent; D001323:Autoantibodies / Q000097:blood*; D001763:Blepharoptosis / Q000175:diagnosis* / Q000276:immunology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D009157:Myasthenia Gravis / Q000175:diagnosis* / Q000276:immunology*; D020794:Receptor Protein-Tyrosine Kinases / Q000276:immunology*; D011950:Receptors, Cholinergic / Q000276:immunology*
D001323:Autoantibodies; D011950:Receptors, Cholinergic; C095714:MUSK protein, human; D020794:Receptor Protein-Tyrosine Kinases