title: Squamous and adenosquamous cell carcinomas of the gallbladder.
abstract: Squamous and adenosquamous cell carcinomas (ASC and SCC) are rare subtypes of gallbladder cancer, traditionally considered more aggressive and with a poorer prognosis than adenocarcinoma. We report about two patients affected by an advanced squamous cell carcinoma of the gallbladder. Both had a large tumour in the gallbladder fossa region with infiltration of the liver. Surgical resection was radical in one, but palliative in the other. pTNM was T3 N0 M0, G3, R0 in the former and T3 N0 M0, G2 R1 in the latter. Patients died for local recurrence after 12 and 5 months, respectively. Natural history, clinical findings, prognosis and outcome of this rare gallbladder tumour are discussed on the basis of a review of the English literature. In conclusion, an aggressive and radical surgical treatment of advanced squamous and adenosquamous cell gallbladder carcinomas seems to be indicated for their low proclivity to distant spreading.
authors.affiliation: Dept. of Surgery Pietro Valdoni, University of Rome La Sapienza, Policlinico Umberto I, Rome, Italy. andrea.mingoli@uniroma1.it
authors.forename: A
authors.initials: A
authors.lastname: Mingoli
authors.forename: G
authors.initials: G
authors.lastname: Brachini
authors.forename: R
authors.initials: R
authors.lastname: Petroni
authors.forename: A
authors.initials: A
authors.lastname: Antoniozzi
authors.forename: F
authors.initials: F
authors.lastname: Cavaliere
authors.forename: L
authors.initials: L
authors.lastname: Simonelli
authors.forename: P
authors.initials: P
authors.lastname: Chirletti
authors.forename: C
authors.initials: C
authors.lastname: Modini
mesh_terms: D000368:Aged; D018196:Carcinoma, Adenosquamous / Q000000981:diagnostic imaging / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D005706:Gallbladder Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D009367:Neoplasm Staging; D011859:Radiography; D015996:Survival Rate; D015898:Tomography Scanners, X-Ray Computed