Modulation of recognition and temporal order memory retrieval by dopamine D1 receptor in rats.
The present study examines the effects of SKF 81297, a selective D1 agonist, on information retrieval in recognition and temporal order memory for objects, using three different tasks. Separate groups of rats were trained in each task and then given an intraperitoneal injection of saline or the D1 agonist (0.03, 0.3 mg/kg), before the memory testing trial in an object recognition, object location, and object temporal order memory tasks. We show that SKF 81297, at high dose (0.3 mg/kg), facilitates information retrieval after a long delay (4 h) in the three memory tasks whereas both high and low doses of D1 agonist impair recognition memory after a short delay (15 min). These results indicate a significant role of dopamine D1 receptors in recognition memory for both familiarity and place of objects in addition to object temporal order memory.
Hotte
Maïté
M
INSERM E0117-Paris V, Bât. P Broca, 2ter rue d'Alésia, 75014 Paris, France.
Naudon
Laurent
L
Jay
Thérèse M
TM
D000704:Analysis of Variance; D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D018491:Dopamine Agonists / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000187:drug effects / Q000378:metabolism*; D021641:Recognition, Psychology / Q000502:physiology*; D012691:Serial Learning / Q000502:physiology*; D013028:Space Perception / Q000502:physiology; D013998:Time Perception / Q000502:physiology*
D001552:Benzazepines; D018491:Dopamine Agonists; D017447:Receptors, Dopamine D1; C067113:SK&F 81297