Oxidative stress during treatment with first- and second-generation antipsychotics.
Neurotoxicity of first-generation antipsychotics (FGAs) may be involved in lipid peroxidation, which is the pathogenesis of extrapyramidal symptoms, including tardive dyskinesia (TD). Blood samples at day 0, 7, and 21 drawn from patients taking antipsychotics were analyzed for malondialdehyde (MDA) in plasma, a marker of lipid peroxidation, by high-performance liquid chromatography. Of 115 patients enrolled, 92 patients completed the study. Most MDA levels were within normal ranges (<1.0 micromol/liter). Malondialdehyde levels in patients receiving clozapine (p = 0.002), quetiapine (p = 0.003), amisulpride (p = 0.008), and risperidone (p = 0.008) were significantly lower than within the first generation antipsychotic group. The authors conclude that lipid peroxidation is significantly higher in treatment with FGAs.
Kropp
Stefan
S
Klinische Psychiatrie und Psychotherapie, Medizinische Hochschule Hannover, Germany. kropp.stefan@mh-hannover.de
Kern
Veronika
V
Lange
Kirsten
K
Degner
Detlef
D
Hajak
Göran
G
Kornhuber
Johannes
J
Rüther
Eckart
E
Emrich
Hinderk M
HM
Schneider
Udo
U
Bleich
Stefan
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001480:Basal Ganglia Diseases / Q000378:metabolism / Q000503:physiopathology; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects*; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000188:drug therapy / Q000378:metabolism
D014150:Antipsychotic Agents; D008315:Malondialdehyde