title: Pyrrolizidine alkaloids from Anchusa strigosa and their antifeedant activity.
abstract: The pyrrolizidine alkaloid (PA) content of flowers, leaves, and roots of Anchusa strigosa (Boraginaceae) was analysed by ESI-LC-MS. Six PAs, including two new natural compounds, were detected, characterized by NMR spectroscopy, and quantified in each plant organ. The results indicated that the highest total concentration of PAs was in the leaves (23.63 mg/g of dried part), followed by the flowers (19.77 mg/g), and finally by the roots (1.80 mg/g). All PAs isolated were subjected to Spodoptera exigua and Pieris brassicae larvae. Feeding activity by both herbivore species using a bioassay was inhibited up to circa 75% depending on PA and applied concentration.
authors.affiliation: Dipartimento di Chimica Bioorganica e Biofarmacia, Università di Pisa, Via Bonanno 33, 56126 Pisa, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Siciliano
authors.forename: Marinella De
authors.initials: MD
authors.lastname: Leo
authors.forename: Ammar
authors.initials: A
authors.lastname: Bader
authors.forename: Nunziatina De
authors.initials: ND
authors.lastname: Tommasi
authors.forename: Klaas
authors.initials: K
authors.lastname: Vrieling
authors.forename: Alessandra
authors.initials: A
authors.lastname: Braca
authors.forename: Ivano
authors.initials: I
authors.lastname: Morelli
mesh_terms: D000818:Animals; D001067:Appetite Depressants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D028082:Boraginaceae / Q000737:chemistry*; D005247:Feeding Behavior / Q000187:drug effects; D035264:Flowers / Q000737:chemistry; D007814:Larva; D007915:Lepidoptera / Q000254:growth & development; D009682:Magnetic Resonance Spectroscopy; D009904:Optical Rotation; D018515:Plant Leaves / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D011763:Pyrrolizidine Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D001067:Appetite Depressants; D011763:Pyrrolizidine Alkaloids