Modified diagnostic criteria of drug-induced liver injury proposed by the international consensus meeting.
OBJECTIVE
The usefulness of the diagnostic criteria of the International Consensus Meeting (criteria A) has been previously reported. However, these criteria are not clinically adaptable in Japan where allergic reaction is one of the major etiologies of drug-induced liver injury and thus it was revised and reported in the Digestive Disease Week-Japan of 2002 as DDW-J criteria (criteria B). It remains controversial whether the revised criteria can exclude drugs not causing liver injury.


METHODS
Two new diagnostic criteria (criteria C and D) were designed to supplement the DDW-J criteria. Usefulness and limitations of the four criteria were retrospectively examined using cases of drug-induced liver injury experienced in 8 hospitals.


RESULTS
It was confirmed that the sensitivity of criteria B is excellent for diagnosis of drug-induced liver injury. However, diagnostic criteria B were found to be disadvantageous in relation to specificity, while diagnostic criteria D were disadvantageous in relation to sensitivity. Sensitivity of diagnostic criteria C was a little superior to that of diagnostic criteria A.


CONCLUSIONS
On the basis, the significant sensitivity of criteria B was confirmed again, however, modification should be done for increasing specificity. Criteria C appear to be the best for their sensitivity and specificity.
Iwasa
Motoh
M
Department of Internal Medicine, Division of Gastroenterology and Hepatology Mie University School of Medicine, Tsu, Japan. motoh@clin.medic.mie-u.ac.jp
Zeniya
Mikio
M
Kumagi
Teru
T
Hisamochi
Akiko
A
Yasuda
Hiroshi
H
Nishiuchi
Meiko
M
Akisawa
Naoaki
N
Mantani
Naoki
N
Watanabe
Masaaki
M
Ito
Tadashi
T
Nakamura
Atsushi
A
Takikawa
Hajime
H
Adachi
Yukihiko
Y
D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000209:etiology; D003937:Diagnosis, Differential; D004347:Drug Interactions; D006525:Hepatitis, Viral, Human / Q000175:diagnosis; D006801:Humans; D007564:Japan; D008111:Liver Function Tests; D012189:Retrospective Studies; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis / Q000209:etiology