New two-amino acid insertion near codon 70 of the HIV type 1 protease gene.
A two-amino acid insertion near codon 70 of the HIV-1 protease gene was found in an individual failing protease inhibitor therapy. Susceptibility of this strain to protease inhibitors was similar to that of non-insert-containing strains with comparable resistance mutations and one or more other major PI mutations.
Winters
Mark A
MA
Division of Infectious Diseases, Stanford University Medical Center, Stanford, California 94305, USA. mark.winters@stanford.edu
Kagan
Ron M
RM
Heseltine
Peter N R
PN
Merigan
Thomas C
TC
D000596:Amino Acids / Q000235:genetics*; D003062:Codon; D024882:Drug Resistance, Viral / Q000235:genetics*; D005814:Genes, Viral; D015658:HIV Infections / Q000821:virology*; D016333:HIV Protease / Q000235:genetics*; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA
D000596:Amino Acids; D003062:Codon; D016333:HIV Protease