title: Electrochemical oxidation of 2-thiouracil at pyrolytic graphite electrode.
abstract: 2-Thiouracil has been studied in phosphate buffers of pH 1.95-11.08 using linear and cyclic sweep voltammetry, coulometry, controlled potential electrolysis and spectral studies. One well-defined oxidation peak I(a) in the pH range 1.95-11.08 was noticed. The number of electrons involved in peak I(a) was found to be four in a thin layer cell whereas under exhaustive electrolysis condition oxidation was found to involve six electrons. A reduction peak II(c) (2e, 2H(+)) is noticed in the reverse sweep. Spectral studies during oxidation were carried out at different pH. Kinetic studies indicated that the decay of the UV-absorbing intermediate is a first order reaction. The products of the electrooxidation have been characterized and a tentative EC mechanism has been suggested for the oxidation of 2-thiouracil.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Roorkeem, Roorkee 247 667, India. mgcyfcy@iitr.ernet.in
authors.forename: Rajendra N
authors.initials: RN
authors.lastname: Goyal
authors.forename: Udai P
authors.initials: UP
authors.lastname: Singh
authors.forename: Adil A
authors.initials: AA
authors.lastname: Abdullah
mesh_terms: D004563:Electrochemistry; D004566:Electrodes; D006108:Graphite / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D010084:Oxidation-Reduction; D013056:Spectrophotometry, Ultraviolet; D013889:Thiouracil / Q000737:chemistry*
chemical_list: D013889:Thiouracil; D006108:Graphite