title: Antihyperlipidemic and antiperoxidative effect of Diasulin, a polyherbal formulation in alloxan induced hyperglycemic rats.
abstract: BACKGROUND
  This study was undertaken to investigation the effect of Diasulin, a poly herbal drug composed of ethanolic extract of ten medicinal plants on blood glucose, plasma insulin, tissue lipid profile, and lipidperoxidation in alloxan induced diabetes.
  
  
  METHODS
  Ethanolic extract of Diasulin a, poly herbal drug was administered orally (200 mg/kg body weight) for 30 days. The different doses of Diasulin on blood glucose and plasma insulin in diabetic rats were studied and the levels of lipid peroxides [TBARS, and hydroperoxide] and tissue lipids [cholesterol, triglyceride, phospholipides and free fatty acids] were also estimated in alloxan induced diabetic rats. The effects were compared with glibenclamide.
  
  
  RESULTS
  Treatment with Diasulin and glibenclamide resulted in a significant reduction of blood glucose and increase in plasma insulin. Diasulin also resulted in a significant decrease in tissue lipids and lipid peroxide formation. The effect produced by Diasulin was comparable with that of glibenclamide.
  
  
  CONCLUSIONS
  The decreased lipid peroxides and tissue lipids clearly showed the antihyperlipidemic and antiperoxidative effect of Diasulin apart from its antidiabetic effect.
authors.affiliation: Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu-608 002, India. saranbio@rediffmail.com
authors.forename: Ramalingam
authors.initials: R
authors.lastname: Saravanan
authors.forename: Leelavinothan
authors.initials: L
authors.lastname: Pari
mesh_terms: D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D002784:Cholesterol / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005905:Glyburide / Q000494:pharmacology; D007328:Insulin / Q000097:blood; D007668:Kidney / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects; D008054:Lipid Peroxides / Q000096:biosynthesis / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000378:metabolism
chemical_list: D001786:Blood Glucose; C507535:Diasulin; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D008054:Lipid Peroxides; D010743:Phospholipids; D010936:Plant Extracts; D014280:Triglycerides; D000496:Alloxan; D002784:Cholesterol; D005905:Glyburide