[Effect of triptolide on urinary monocyte chemottractant protein-1 in patients with diabetic nephropathy].
OBJECTIVE
To observe the change of urinary monocyte chemottractant protein-1 (MCP-1) in patients with diabetic nephropathy (DN), and to explore the therapeutic effect and mechanism of triptolide (TL) in treating DN.


METHODS
Thirty-five patients in the treated group were treated with TL plus benazepril and thirty two patients in the control group were treated with benazepril alone for six months. The change of urinary MCP-1 was measured before and after treatment.


RESULTS
Level of urinary MCP-1 in DN patients was significantly higher than that in healthy subjects (P < 0.01), but it could be significantly decreased after TL treatment, showing significant difference as compared with that in the control group (P < 0.05).


CONCLUSIONS
Determination of urinary MCP-1 level is beneficial to know the degree of kidney inflammation in DN patients. TL can inhibit inflammatory reaction to decrease the level of urinary MCP-1, and thus improve the renal function.
Song
Hai-xiang
HX
Linyi Municipal Hospital of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Shandong.
Gong
Jing
J
Chen
Wen
W
D000328:Adult; D000368:Aged; D018932:Chemokine CCL2 / Q000652:urine*; D003928:Diabetic Nephropathies / Q000188:drug therapy* / Q000652:urine; D004224:Diterpenes / Q000627:therapeutic use*; D004852:Epoxy Compounds; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010616:Phenanthrenes / Q000627:therapeutic use*; D008517:Phytotherapy; D011446:Prospective Studies
D018932:Chemokine CCL2; D004224:Diterpenes; D004852:Epoxy Compounds; D007166:Immunosuppressive Agents; D010616:Phenanthrenes; C001899:triptolide