Synthesis and antiplatelet activity of thioaryloxyacids analogues of clofibric acid.
The thiophene-, benzothiazole- and pyridine-thioaryloxyacids analogues of clofibric acid were synthesized and their antiplatelet activity was screened. Some compounds exhibited antiaggregating properties. The platelet-related haemostasis was measured on a PFA-100 analyzer using bull blood.
Ammazzalorso
Alessandra
A
Dipartimento di Scienze del Farmaco, Università degli Studi G. D'Annunzio, via dei Vestini, 66100 Chieti, Italy.
Amoroso
Rosa
R
Baraldi
Mario
M
Bettoni
Giancarlo
G
Braghiroli
Daniela
D
De Filippis
Barbara
B
Giampietro
Letizia
L
Tricca
Maria L
ML
Vezzalini
Francesca
F
D000818:Animals; D002417:Cattle; D002995:Clofibric Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D000960:Hypolipidemic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D013844:Thiazoles / Q000138:chemical synthesis / Q000494:pharmacology*
D000960:Hypolipidemic Agents; D013844:Thiazoles; D002995:Clofibric Acid