title: Antimicrobial activity and a comparison of published pharmacodynamics of gemifloxacin and eight fluoroquinolones against Streptococcus pneumoniae.
abstract: Gemifloxacin was evaluated for its in vitro activity and was compared with eight fluoroquinolones. Pharmacodynamic comparisons were made based on published pharmacokinetic information. Gemifloxacin demonstrated excellent in vitro activity (minimum inhibitory concentration necessary to inhibit 90% of the strains tested, MIC90 = 0.03 mg/L (range 0.0019-0.03 mg/L)) against 199 strains of Streptococcus pneumoniae. Its activity was not influenced by penicillin or ciprofloxacin non-susceptibility. Gemifloxacin demonstrated excellent pharmacodynamic parameters, with a Cmax/MIC90 of 67 (where Cmax is the peak serum level) and an AUC/MIC90 of 297 (where AUC is the area under the curve). Compared with the other eight fluoroquinolones tested, gemifloxacin demonstrated the best in vitro activity and Cmax/MIC90.
authors.affiliation: Department of Medicine Research Laboratory, St John's Hospital & Medical Center and Wayne State University School of Medicine, 22201 Moross, Suite 80, Detroit, MI 48236, USA. louis.saravolatz@stjohn.org
authors.forename: Louis
authors.initials: L
authors.lastname: Saravolatz
authors.forename: Odette
authors.initials: O
authors.lastname: Manzor
authors.forename: Joan
authors.initials: J
authors.lastname: Pawlak
authors.forename: Bradley
authors.initials: B
authors.lastname: Belian
mesh_terms: D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D019540:Area Under Curve; D024841:Fluoroquinolones / Q000493:pharmacokinetics / Q000494:pharmacology*; D000077735:Gemifloxacin; D006801:Humans; D008826:Microbial Sensitivity Tests; D009287:Naphthyridines / Q000493:pharmacokinetics / Q000494:pharmacology*; D013296:Streptococcus pneumoniae / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; D000077735:Gemifloxacin