title: Pathophysiological roles of ectopic tachygastria induced with antral electrical stimulation.
abstract: OBJECTIVE
  To investigate the pathophysiological roles of tachygastria using antral electrical stimulation (AES).
  
  
  METHODS
  The study was performed on 13 healthy female hound-type dogs chronically implanted with three pairs of serosal electrodes and a gastric cannula (n = 7). In the first experiment (n = 7), the antral motility was measured for three 30-min periods right after a solid meal. AES was performed during the second 30-min period at a tachygastric frequency. In the second experiment (n = 6), gastric slow waves and animal behavior were monitored in the fasting state at baseline and with various parameters of AES.
  
  
  RESULTS
  (1) AES at tachygastric frequencies (7-14 cpm) significantly reduced the percentage of normal 4- to 6-cpm slow waves and induced tachygastria; (2) AES significantly and substantially inhibited the antral motility in the fed state; (3) AES in the fasting state energy dependently induced symptoms, and the symptom score was linearly correlated with the stimulation frequency, and (4) there was a significant negative correlation between percentage of tachygastria and index of antral motility.
  
  
  CONCLUSIONS
  AES induces tachygastria and inhibits the antral motility. Tachygastria is correlated with antral motility.
authors.affiliation: Veterans Administration Research Foundation, Oklahoma City, OK, USA.
authors.forename: Hongbing
authors.initials: H
authors.lastname: Zhu
authors.forename: Hui
authors.initials: H
authors.lastname: Ouyang
authors.forename: J D Z
authors.initials: JD
authors.lastname: Chen
mesh_terms: D000818:Animals; D004285:Dogs; D004558:Electric Stimulation; D004594:Electrophysiology; D005215:Fasting / Q000502:physiology; D005260:Female; D016065:Myoelectric Complex, Migrating / Q000502:physiology*; D019518:Postprandial Period / Q000502:physiology; D011706:Pyloric Antrum / Q000503:physiopathology*