Primary study on the application of Serum Pharmacology in Chinese traditional medicine.
In the paper, two main methods, which are Serum Pharmacology and Traditional Pharmacology, were adopted to study Chinese traditional medicine, such as Ginkgo biloba extract (GBE), ginsenosides (GS) and compound GG (GBE+GS), pharmacology in vitro. The results showed that there were evident difference between the results of Serum Pharmacology and that of Traditional Pharmacology. There was no significant difference between the drug effect of crude GS on nitric oxide (NO) production in ECV304 and that of crude GBE, and the drug effect of GG was superior to that of GS and GBE, respectively. But, compared with GBE serum, the GS serum up-regulation of NO production in ECV304 increased significantly, and the GG serum up-regulation of the NO production in ECV304 was inferior to that of GS serum and GBE serum significantly. The results suggested that Serum Pharmacological study should be adopted in the pharmacological investigation on the Chinese traditional medicine and the drug screening of the Chinese traditional medicine.
Bochu
Wang
W
Key Laboratory for Biomechanics & Tissue Engineering under the State Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, PR China. wangbc2000@yahoo.com.cn
Liancai
Zhu
Z
Qi
Chen
C
D000818:Animals; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism; D020441:Ginkgo biloba / Q000737:chemistry; D036145:Ginsenosides / Q000097:blood*; D006801:Humans; D007202:Indicators and Reagents; D015227:Lipid Peroxidation / Q000187:drug effects; D008516:Medicine, Chinese Traditional; D009569:Nitric Oxide / Q000096:biosynthesis; D005894:Panax / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011817:Rabbits
D036145:Ginsenosides; D007202:Indicators and Reagents; D010936:Plant Extracts; D009569:Nitric Oxide