title: Usefulness of relative lymphocyte count as an independent predictor of death/urgent transplant in heart failure.
abstract: The usefulness of low relative lymphocyte count as an independent predictor of death/urgent transplant in patients with heart failure (HF) and the association between low relative lymphocyte count and neurohormone and cytokine activation were investigated. Relative lymphocyte count, clinical variables, neurohormones, and cytokines were measured in 129 outpatients with HF. Follow-up extended to a mean of 3.0 +/- 1.2 years for death/urgent transplant. Low relative lymphocyte count was independently associated with a 3.4-fold increased risk of death/urgent transplant. Relative lymphocyte count was positively associated with hemoglobin and inversely associated with age, jugular venous pressure, creatinine, leukocyte count, and soluble tumor necrosis factor receptor-1. There was only a borderline inverse association with cortisol levels during evening hours.
authors.affiliation: Department of Internal Medicine, University of Washington, Seattle, Washington 98195, USA.
authors.forename: Kier V
authors.initials: KV
authors.lastname: Huehnergarth
authors.forename: Dariush
authors.initials: D
authors.lastname: Mozaffarian
authors.forename: Mark D
authors.initials: MD
authors.lastname: Sullivan
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Crane
authors.forename: Charles W
authors.initials: CW
authors.lastname: Wilkinson
authors.forename: Richard L
authors.initials: RL
authors.lastname: Lawler
authors.forename: George B
authors.initials: GB
authors.lastname: McDonald
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Fishbein
authors.forename: Wayne C
authors.initials: WC
authors.lastname: Levy
mesh_terms: D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood; D016757:Death, Sudden, Cardiac / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000097:blood* / Q000401:mortality; D016027:Heart Transplantation; D006801:Humans; D015994:Incidence; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D011863:Radioimmunoassay; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate
chemical_list: D015415:Biomarkers; D016207:Cytokines; D009638:Norepinephrine