Coevolution of the relaxin-like peptides and their receptors.
Currently, four relaxin peptide family receptors are known: LGR7 is the relaxin receptor, although it also interacts specifically with relaxin-3; LGR8 is the insulin-like factor 3 (INSL3) receptor; and GPCR135 or the somatostatin- and angiotensin-like peptide receptor (SALPR) and GPCR142 are both specific relaxin-3 receptors. Because these receptors coevolved together with their relaxin ligands, phylogenetic analysis of these sequences can provide insight into peptide-receptor interactions and even predict interacting partners for INSL4, INSL5, and INSL6, the receptors for which are unknown.
Wilkinson
Tracey N
TN
Howard Florey Institute, The University of Melbourne, Victoria 3010, Australia.
Speed
Terence P
TP
Tregear
Geoffrey W
GW
Bathgate
Ross A D
RA
D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D007328:Insulin / Q000235:genetics* / Q000378:metabolism*; D010802:Phylogeny; D011506:Proteins / Q000235:genetics* / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled; D018000:Receptors, Peptide / Q000235:genetics* / Q000378:metabolism*
D007328:Insulin; C084797:Leydig insulin-like protein; D011506:Proteins; D043562:Receptors, G-Protein-Coupled; D018000:Receptors, Peptide; C033395:relaxin receptors