Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica.
[structure: see text] Analysis of the fermentation broth of a strain of the marine actinomycete Salinispora tropica has led to the isolation of two unprecedented macrolides, sporolides A (1) and B (2). The structures and absolute stereochemistries of both metabolites were elucidated using a combination of NMR spectroscopy and X-ray crystallography.
Buchanan
Greg O
GO
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92093-0204, USA.
Williams
Philip G
PG
Feling
Robert H
RH
Kauffman
Christopher A
CA
Jensen
Paul R
PR
Fenical
William
W
D039903:Actinobacteria / Q000737:chemistry*; D018360:Crystallography, X-Ray; D016984:Enterococcus faecium / Q000187:drug effects; D006801:Humans; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D008386:Marine Biology; D016106:Methicillin Resistance / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013211:Staphylococcus aureus / Q000187:drug effects; D014407:Tumor Cells, Cultured; D020713:Vancomycin Resistance / Q000187:drug effects
D018942:Macrolides; C509191:sporolide A