title: Long-term course of post-transplant mesangial IgA deposition: clinicopathologic study of nine cases.
abstract: We conducted the present study to elucidate the fate of post-transplant mesangial IgA deposit under the long-term observation. Out of a total of 45 cases with post-transplant mesangial IgA deposition, nine cases with more than 4 yr of follow-up term were enrolled in this study, and clinicopathologic characteristics were described. The study included three men and six women with a mean age of 34.2 yr. The average observation time from the detection of mesangial IgA deposition was 6.1 yr. Three cases were categorized as recurrent IgA nephropathy, while six cases were classified into latent mesangial IgA deposition. One case with hypertension developed end-stage renal disease. The significant improvement in microscopic hematuria was observed in one recurrent IgA nephropathy case. Microscopic findings included mild mesangial stalk thickening in all but one case. IgA deposition demonstrated a significant decrease in three latent mesangial IgA deposition cases. No apparent reduction in dense deposit quantity was observed on electron microscopy. There was no association between clinicopathologic findings and the regimen of anti-immunosuppressive agents. This study showed the improvement of the disease activity did occur in both recurrent IgA nephropathy and latent mesangial IgA deposition. Further investigation of latent mesangial IgA deposition may present the important clue to the pathogenesis of IgA nephropathy.
authors.affiliation: Department of Pathology, Toranomon Hospital, Tokyo, Japan. Shigeohara@aol.com
authors.forename: Shigeo
authors.initials: S
authors.lastname: Hara
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Shigeko
authors.initials: S
authors.lastname: Hara
authors.forename: Akihide
authors.initials: A
authors.lastname: Tanimoto
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Seki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsushita
authors.forename: Shinji
authors.initials: S
authors.lastname: Tomikawa
authors.forename: Keihachiro
authors.initials: K
authors.lastname: Kuzuhara
mesh_terms: D000328:Adult; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D005920:Glomerular Mesangium / Q000378:metabolism* / Q000473:pathology*; D005922:Glomerulonephritis, IGA / Q000209:etiology / Q000473:pathology; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism*; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012008:Recurrence; D012307:Risk Factors; D013997:Time Factors
chemical_list: D007070:Immunoglobulin A