title: Scoring proteomes with proteotypic peptide probes.
abstract: Technologies for genome-wide analyses typically undergo a transition from a discovery phase to a scoring phase. In the discovery phase, the genomic universe is explored and all pertinent data are noted. In the scoring phase, relevant entities are screened to reveal groups of genes that are associated with specific biological processes or conditions. In this article, we propose that the transition from a discovery to a scoring phase is also essential, feasible and imminent for proteomics.
authors.affiliation: Department of Analytical Sciences and Informatics, Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany. bernhard.kuster@cellzome.com
authors.forename: Bernhard
authors.initials: B
authors.lastname: Kuster
authors.forename: Markus
authors.initials: M
authors.lastname: Schirle
authors.forename: Parag
authors.initials: P
authors.lastname: Mallick
authors.forename: Ruedi
authors.initials: R
authors.lastname: Aebersold
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D016678:Genome; D023281:Genomics; D006801:Humans; D008957:Models, Genetic; D008969:Molecular Sequence Data; D010455:Peptides; D011494:Protein Kinases / Q000737:chemistry / Q000378:metabolism; D011506:Proteins / Q000737:chemistry / Q000235:genetics; D020543:Proteome
chemical_list: D010455:Peptides; D011506:Proteins; D020543:Proteome; D011494:Protein Kinases