Isotretinoin does have an adverse effect on bone mineral density.
Milstone
Leonard M
LM
Insogna
Karl L
KL
Leachman
Sancy A
SA
D015519:Bone Density / Q000187:drug effects*; D003879:Dermatologic Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects*; D008297:Male
D003879:Dermatologic Agents; D015474:Isotretinoin