title: A 13-week toxicity study of bismuth in rats by intratracheal intermittent administration.
abstract: Although bismuth is widely used as a lead substitute in the industrial field, the toxicity of bismuth by inhalation is little known. We performed a 13-wk intratracheal intermittent bismuth dose toxicity study. Bismuth was administered at dose levels of 0, 0.8, 4, 20 mg/kg to male Crj:CD(SD)IGS rats (SPF) by intratracheal intermittent administration once a week for thirteen weeks to investigate its potential toxic effects; especially for specific adverse effects and changes related to pre-neoplastic lesions. Our results showed foreign body inflammation in the lungs, which was caused by intratracheal administration of bismuth, and physical changes related to pulmonary lesions; however, there were no serious changes in other organs. We concluded that dose-dependent, but not specific adverse effects, were attributable to bismuth inhalation in the rat.
authors.affiliation: Department of Preventative Medicine and Public Health, School of Medicine, Keio University, Japan. sanoyuri@sc.itc.keio.ac.jp
authors.forename: Yuri
authors.initials: Y
authors.lastname: Sano
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Satoh
authors.forename: Momoko
authors.initials: M
authors.lastname: Chiba
authors.forename: Atsuko
authors.initials: A
authors.lastname: Shinohara
authors.forename: Masahide
authors.initials: M
authors.lastname: Okamoto
authors.forename: Koji
authors.initials: K
authors.lastname: Serizawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakashima
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Omae
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D001729:Bismuth / Q000008:administration & dosage / Q000032:analysis / Q000633:toxicity*; D008168:Lung / Q000737:chemistry; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001729:Bismuth