title: Hydrophobic and electronic factors in the design of dialkylglycine decarboxylase mimics.
abstract: The first functional catalytic mimic of the enzyme dialkylglycine decarboxylase is described. This system utilizes a hydrophobically modified polyethylenimine polymer, a pyridoxamine cofactor, and a 2-aryl-2-alkylglycine sacrificial amine source to convert alpha-keto acids to alpha-amino acids at biologically relevant temperatures with multiple turnovers of the pyridoxamine catalyst. The effects of hydrophobic and electronic factors in the 2,2-disubstituted sacrificial amine source and the pyridoxamine catalyst on turnover frequency and turnover number are explored.
authors.affiliation: Columbia University, Department of Chemistry, 3000 Broadway, New York, NY 10027, USA.
authors.forename: Jason J
authors.initials: JJ
authors.lastname: Chruma
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.forename: Wenjun
authors.initials: W
authors.lastname: Zhou
authors.forename: Ronald
authors.initials: R
authors.lastname: Breslow
mesh_terms: D002384:Catalysis; D050841:Glycine Dehydrogenase (Decarboxylating) / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D018716:Molecular Mimicry
chemical_list: D050841:Glycine Dehydrogenase (Decarboxylating)