Inhibition of platelet aggregation with eptifibatide, bivalirudin, and heparin in patients undergoing percutaneous coronary intervention receiving clopidogrel pretreatment (The PharmacoDynamic Evaluation of Angiomax, Clopidogrel with or without INtegrilin [DEACON] study).
The present study assessed the magnitude of inhibition of platelet aggregation induced by adenosine diphosphate and thrombin receptor activating peptide achieved with unfractionated heparin, the direct thrombin inhibitor bivalirudin, and the glycoprotein IIb/IIIa inhibitor eptifibatide in patients who underwent percutaneous coronary intervention and and were treated with concomitant aspirin and clopidogrel.
Saucedo
Jorge F
JF
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA. jorge-saucedo@ouhsc.edu
Aude
Wady
W
Pacheco
Rebecca
R
Thorn
Brett
B
Matin
Zakaria
Z
Husain
Khawaja
K
Garza
Luis
L
D015906:Angioplasty, Balloon, Coronary; D000925:Anticoagulants / Q000493:pharmacokinetics / Q000627:therapeutic use; D000077144:Clopidogrel; D004359:Drug Therapy, Combination; D000077542:Eptifibatide; D005260:Female; D005500:Follow-Up Studies; D006493:Heparin / Q000627:therapeutic use*; D006629:Hirudins / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000628:therapy*; D010446:Peptide Fragments / Q000493:pharmacokinetics* / Q000627:therapeutic use; D010455:Peptides / Q000493:pharmacokinetics* / Q000627:therapeutic use; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000493:pharmacokinetics / Q000627:therapeutic use; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors; D011300:Preoperative Care / Q000379:methods; D011994:Recombinant Proteins / Q000493:pharmacokinetics / Q000627:therapeutic use; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D016896:Treatment Outcome
D000925:Anticoagulants; D006629:Hirudins; D010446:Peptide Fragments; D010455:Peptides; D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D011994:Recombinant Proteins; D006493:Heparin; D000077144:Clopidogrel; D000077542:Eptifibatide; D013988:Ticlopidine; C074619:bivalirudin