title: [A patient with pleural thickening of sarcoidosis].
abstract: We report a 51-year-old woman with characteristic pleural involvement of sarcoidosis. Video-assisted thoracoscopic examination identified diffuse pleural thickening in the right lung, which coincided in distribution with parenchymal reticular shadows demonstrated with high-resolution thoracic CT scan. Biopsied specimens revealed epithelioid cell granuloma with noncaseating necrosis and multi-nucleated giant cells in the parenchymal lung tissue. Infiltration of inflammatory cells was demonstrated in the thickened pleural tissue, but no typical sarcoid lesion. This pleural lesion was considered as pleural involvement of sarcoidosis, since deterioration of the pleural thickening was accompanied with progression of a parenchymal sarcoid lesion during the period of two months after biopsy. Video-assisted thoracoscopy and high-resolution CT scan both supported the diagnosis of sarcoidosis with pleural involvement.
authors.affiliation: Department of Respiratory Medicine, Juntendo Tokyo Koto Geriatric Medical Center.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Miyaji
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Konno
authors.forename: Mariko
authors.initials: M
authors.lastname: Yamazaki
authors.forename: Akihiko
authors.initials: A
authors.lastname: Ohwada
mesh_terms: D001706:Biopsy; D005260:Female; D006801:Humans; D007249:Inflammation / Q000473:pathology; D008875:Middle Aged; D010994:Pleura / Q000000981:diagnostic imaging / Q000473:pathology*; D017565:Sarcoidosis, Pulmonary / Q000000981:diagnostic imaging / Q000473:pathology*; D020775:Thoracic Surgery, Video-Assisted; D014057:Tomography, X-Ray Computed / Q000379:methods