title: Thyroid function after assisted reproductive technology in women free of thyroid disease.
abstract: OBJECTIVE
  To evaluate thyroid function in women undergoing a first assisted reproductive technology (ART) procedure and to compare women with ongoing pregnancy or miscarriage.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Tertiary referral center.
  
  
  METHODS
  Seventy-seven women free of thyroid disease.
  
  
  METHODS
  Serum TSH and FT4 were determined before and 2, 4, and 6 weeks after ET. All women received the same ART protocol.
  
  
  METHODS
  Thyroid function.
  
  
  RESULTS
  Forty-five women had ongoing pregnancies, and 32 suffered a miscarriage after 6.7 weeks (range 5-11). Mean age and number of ET were similar in both groups. Compared with baseline values, TSH and FT4 increased significantly 2 weeks after ET (ongoing pregnancies group: TSH 2.5 +/- 1.3 vs. 1.6 +/- 0.8 mU/L and FT4 13.8 +/- 1.4 vs. 12.4 +/- 1.8 ng/L; miscarriage group: TSH 2.1 +/- 1.0 vs. 1.5 +/- 0.7 mU/L and FT4 14.2 +/- 2.0 vs. 12.4 +/- 1.9 ng/L). Pregnancy outcome did not affect thyroid function and its evolution over time.
  
  
  CONCLUSIONS
  In women free of thyroid diseases, thyroid function changed significantly after ART, but these changes were not different between women with ongoing pregnancy and miscarriage.
authors.affiliation: Department of Endocrinology, Vrije Universiteit Brussel, Brussels, Belgium. hemopek@az.vub.ac.be
authors.forename: Kris
authors.initials: K
authors.lastname: Poppe
authors.forename: Daniel
authors.initials: D
authors.lastname: Glinoer
authors.forename: Herman
authors.initials: H
authors.lastname: Tournaye
authors.forename: Johan
authors.initials: J
authors.lastname: Schiettecatte
authors.forename: Patrick
authors.initials: P
authors.lastname: Haentjens
authors.forename: Brigitte
authors.initials: B
authors.lastname: Velkeniers
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood / Q000453:epidemiology; D000328:Adult; D000704:Analysis of Variance; D005260:Female; D006801:Humans; D011247:Pregnancy; D011446:Prospective Studies; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects / Q000706:statistics & numerical data; D013959:Thyroid Diseases / Q000097:blood* / Q000453:epidemiology; D013960:Thyroid Function Tests / Q000706:statistics & numerical data; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D013997:Time Factors
chemical_list: D013972:Thyrotropin; D013974:Thyroxine