title: Anxiety reduction through detachment: subjective, physiological, and neural effects.
abstract: The ability to volitionally regulate emotions helps to adapt behavior to changing environmental demands and can alleviate subjective distress. We show that a cognitive strategy of detachment attenuates subjective and physiological measures of anticipatory anxiety for pain and reduces reactivity to receipt of pain itself. Using functional magnetic resonance imaging, we locate the potential site and source of this modulation of anticipatory anxiety in the medial prefrontal/anterior cingulate and anterolateral prefrontal cortex, respectively.
authors.affiliation: University College London, UK. rkalisch@fil.ion.ucl.ac.uk
authors.forename: Raffael
authors.initials: R
authors.lastname: Kalisch
authors.forename: Katja
authors.initials: K
authors.lastname: Wiech
authors.forename: Hugo D
authors.initials: HD
authors.lastname: Critchley
authors.forename: Ben
authors.initials: B
authors.lastname: Seymour
authors.forename: John P
authors.initials: JP
authors.lastname: O'Doherty
authors.forename: David A
authors.initials: DA
authors.lastname: Oakley
authors.forename: Philip
authors.initials: P
authors.lastname: Allen
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Dolan
mesh_terms: D000223:Adaptation, Psychological / Q000502:physiology*; D000328:Adult; D001007:Anxiety / Q000523:psychology*; D001931:Brain Mapping; D003717:Denial, Psychological; D004644:Emotions / Q000502:physiology; D005260:Female; D006179:Gyrus Cinguli / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010146:Pain / Q000523:psychology; D017397:Prefrontal Cortex / Q000502:physiology*; D012016:Reference Values; D014836:Volition / Q000502:physiology