[Repairing segmental radial bone defect with poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/sol-gel bioactive glass composite porous scaffold].
OBJECTIVE
To investigate the capability of the bone regeneration of poly (3-hydroxybutyrate-co-3-hydroxyvalerate/sol-gel bioactive glass (PHBV/SGBG) composite porous scaffold.


METHODS
PHBV/ SGBG composite porous scaffold was implanted into the segmental radial bone defect of the New Zealand white rabbits, PHBV/hydroxylapatite (PHBV/HA) as experimental control. The degradability, biocompatibility, and bone regeneration capability of the implants were evaluated through radiological, histological, computerized graphic, and biomechanical analysis.


RESULTS
The new bone formation occurred as early as 4 weeks after implantation of PHBV/SGBG composite porous scaffold. The defect was filled with new bone 8 weeks after the implantation, and was completely repaired 12 weeks after operation. The new bone had normal bone structure and the medullar cavity regenerated. The biomechanical study showed that the anti-compression force of radial specimen in PHBV/SGBG groups was significantly higher than in PHBV/ HA groups (P < 0.05), but no significant difference existed between PHBV/SGBG group and autograft bone group (P>0.05). The PHBV/SGBG composite porous scaffold degraded no sooner than 4 weeks after the implantation and most of scaffold was absorbed after 12 weeks. The proportion of the scaffold to new bone decreased from 60% by week 4 to 8% by week 12.


CONCLUSIONS
PHBV/SGBG composite porous scaffold is a degradable bone substitute. It can achieve early bone generation and complete repair. It can be used as an ideal scaffold for tissue-engineering bone.
Yu
Sheng-ji
SJ
Department of Orthopaedic, Cancer Hospital, CAMS and PUMC, Beijing 100210, China. shengjiyu@126.com
Qiu
Gui-xing
GX
Xin
Da-jiang
DJ
Chen
Xiao-feng
XF
Zheng
Yu-dong
YD
Wang
Ying-jun
YJ
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use; D018786:Bone Substitutes / Q000627:therapeutic use*; D002478:Cells, Cultured; D005260:Female; D017102:Fracture Healing / Q000502:physiology; D008297:Male; D010006:Osteoblasts / Q000473:pathology; D011091:Polyesters / Q000627:therapeutic use*; D011817:Rabbits; D011884:Radius / Q000473:pathology / Q000601:surgery; D011885:Radius Fractures / Q000473:pathology / Q000601:surgery*; D000094122:Polyhydroxybutyrates
D001672:Biocompatible Materials; D018786:Bone Substitutes; D011091:Polyesters; C052620:poly(3-hydroxybutyrate)-co-(3-hydroxyvalerate); D000094122:Polyhydroxybutyrates