title: Synthesis of poly-O-sulfated glycosides of 2,5-anhydro-D-mannitol.
abstract: 2,5-Anhydro-3-O-beta-D-glucopyranosyl-; -3-O-alpha-L-idopyranosyl-; -3-O-alpha-D-arabinopyranosyl-; -3-O-alpha-L-arabinopyranosyl-; -3-O-beta-D-maltopyranosyl-; -3-O-beta-D-gentiobiopyranosyl-; -1,6-di-O-beta-D-glucopyranosyl-; -1,6-di-O-alpha-L-idopyranosyl-; -1-O-beta-D-maltopyranosyl-; -1,3,6-tri-O-beta-D-glucopyranosyl-; -1,6-di-O-beta-maltopyranosyl- and -1,6-di-O-beta-D-gentiobiopyranosyl-2,5-anhydro-D-mannitol as well as their poly-O-sulfated derivatives were synthesized. The IP3-IC50 values of their sodium and/or potassium salts were determined for structure-activity studies aiming at the synthesis of new, orally active antiasthmatic compounds.
authors.affiliation: IVAX Drug Research Institute, H-1325 Budapest, PO Box 82, Hungary. janos.kuszmann@idri.hu
authors.forename: János
authors.initials: J
authors.lastname: Kuszmann
authors.forename: Gábor
authors.initials: G
authors.lastname: Medgyes
authors.forename: Sándor
authors.initials: S
authors.lastname: Boros
mesh_terms: D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry*; D008353:Mannitol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D013431:Sulfates / Q000737:chemistry*
chemical_list: D006027:Glycosides; D013431:Sulfates; D008353:Mannitol; C031765:2,5-anhydromannitol