title: Association of fatty acids in serum phospholipids with hay fever, specific and total immunoglobulin E.
abstract: The dietary intake of certain fatty acids might contribute to the development of allergic diseases such as hay fever and asthma. We investigated the association between the concentrations of fifteen fatty acids in serum phospholipids, as a marker of dietary intake and metabolism, and hay fever, allergic sensitisation and total IgE in adults. Data from a population-based cross-sectional study on respiratory health, including the measurement of fatty acids in the serum phospholipids of 740 adults between 20 and 64 years of age, were analysed. Positive associations were found between hay fever and arachidonic acid, and allergic sensitisation and oleic acid. No other fatty acids showed any association with hay fever or allergic sensitisation. Elevated levels of total IgE were not related to fatty acids. Concentrations of long-chain n-3 fatty acids, trans fatty acids or saturated fatty acids in serum phospholipids were not associated with allergic diseases in adults in this study. The present result on the association between hay fever and arachidonic acid is consistent with current hypotheses but warrants further research.
authors.affiliation: GSF-National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany.
authors.forename: Iris
authors.initials: I
authors.lastname: Kompauer
authors.forename: Hans
authors.initials: H
authors.lastname: Demmelmair
authors.forename: Berthold
authors.initials: B
authors.lastname: Koletzko
authors.forename: Gabriele
authors.initials: G
authors.lastname: Bolte
authors.forename: Jakob
authors.initials: J
authors.lastname: Linseisen
authors.forename: Joachim
authors.initials: J
authors.lastname: Heinrich
mesh_terms: D000328:Adult; D016718:Arachidonic Acid / Q000032:analysis; D016001:Confidence Intervals; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D005060:Europe; D005227:Fatty Acids / Q000032:analysis*; D015525:Fatty Acids, Omega-3 / Q000097:blood; D005260:Female; D006306:Health Surveys; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010743:Phospholipids / Q000097:blood / Q000737:chemistry*; D006255:Rhinitis, Allergic, Seasonal / Q000097:blood* / Q000276:immunology; D017678:Sex Distribution
chemical_list: D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D010743:Phospholipids; D016718:Arachidonic Acid; D007073:Immunoglobulin E