title: Speech-induced aphasic seizures in epilepsy caused by LGI1 mutation.
abstract: OBJECTIVE
  Patients with autosomal dominant lateral temporal lobe epilepsy (ADTLE) may have seizures precipitated by sound or speech. We have examined a patient with speech-induced seizures caused by an LGI1 mutation (C46R).
  
  
  METHODS
  A clinical study and a video-EEG recording using interrogative speech as the activation procedure was performed in a 23-year-old man.
  
  
  RESULTS
  He had experienced short episodes of sensory aphasia in situations in which he was suddenly verbally addressed. Voices became distorted, and he could not comprehend despite hearing words. The day after a late party, his girlfriend unexpectedly spoke to him. Her speech became unintelligible to him. He did not reply and had a generalized tonic-clonic (GTC) seizure. During an EEG, he was suddenly asked for the names of his siblings. He answered, but lost understanding of the further conversation and described how syllables floated together with an echoing character. With a versive movement to the right, another GTC occurred. In the EEG, rhythmic 6-Hz activity built up in the frontotemporal areas starting on the left side with bilateral and posterior spreading. Postictal slowing was symmetrical, and no aphasia was noted on awakening.
  
  
  CONCLUSIONS
  To our knowledge, this is the first video-EEG recorded seizure in LGI1-caused ADTLE. This peculiar seizure semiology and precipitating effect of speech may serve as a marker for identifying further individuals with this particular phenotype and genotype and may indicate that the LGI1 gene may have a physiologic function connected to the human capacity for speech and language.
authors.affiliation: Department of Neurology, St. Olav's Hospital, University Hospital, Trondheim, Norway. eylert.brodtkorb@medisin.ntnu.no
authors.forename: Eylert
authors.initials: E
authors.lastname: Brodtkorb
authors.forename: Ralf P
authors.initials: RP
authors.lastname: Michler
authors.forename: Wenli
authors.initials: W
authors.lastname: Gu
authors.forename: Ortrud K
authors.initials: OK
authors.lastname: Steinlein
mesh_terms: D000161:Acoustic Stimulation / Q000009:adverse effects; D000328:Adult; D001037:Aphasia / Q000175:diagnosis / Q000235:genetics*; D004569:Electroencephalography / Q000706:statistics & numerical data*; D020195:Epilepsy, Reflex / Q000175:diagnosis / Q000235:genetics*; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis / Q000235:genetics*; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D009154:Mutation; D010641:Phenotype; D011506:Proteins / Q000235:genetics*; D012640:Seizures / Q000175:diagnosis / Q000235:genetics; D013060:Speech / Q000502:physiology; D014743:Videotape Recording / Q000706:statistics & numerical data
chemical_list: D005819:Genetic Markers; D047908:Intracellular Signaling Peptides and Proteins; C116499:LGI1 protein, human; D011506:Proteins