title: Maternal treatment with MCI-186 does not improve delayed deterioration of cellular bioenergetic state and mitochondrial activity following transient intrauterine ischemia in the fetal rat brain.
abstract: The mitochondrial respiratory activities and energy metabolism in the fetal rat brain were measured at the end of 30 minutes of intrauterine ischemia and after 2 and 4 hours of recirculation. The transient ischemia was associated with a delayed deterioration of cellular bioenergetic state and mitochondrial activities. The deterioration was not prevented by a free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), given immediately after recirculation.
authors.affiliation: Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan.
authors.forename: Akishige
authors.initials: A
authors.lastname: Yokota
authors.forename: Akihito
authors.initials: A
authors.lastname: Nakai
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Taniuchi
authors.forename: Naotaka
authors.initials: N
authors.lastname: Okuda
authors.forename: Masako
authors.initials: M
authors.lastname: Nakai
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Takeshita
mesh_terms: D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism; D002545:Brain Ischemia / Q000378:metabolism*; D000077553:Edaravone; D004734:Energy Metabolism / Q000187:drug effects*; D005260:Female; D005311:Fetal Hypoxia / Q000378:metabolism*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D008928:Mitochondria / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000378:metabolism
chemical_list: D016166:Free Radical Scavengers; D000077553:Edaravone; D000983:Antipyrine