Preoperative administration of chlormadinone acetate reduces blood loss associated with transurethral resection of the prostate: a prospective randomized study.
OBJECTIVE
To assess the effects of giving chlormadinone acetate (CMA) before surgery on blood loss associated with transurethral resection of the prostate (TURP), in a prospective randomized controlled study.


METHODS
Candidates for TURP among patients with benign prostatic hyperplasia were randomized to either treatment with CMA (CMA+) or not (CMA-). In principle, CMA was started at least 28 days before TURP and continued until just before surgery.


RESULTS
In all, 33 patients in the CMA+ (median duration of treatment 34.5 days) and 38 in the CMA- group were evaluable. The mean blood loss during TURP was less in the CMA+ (237.3 mL) than in the CMA- group (263.1 mL), but the difference was not significant. There was significantly less blood loss per gram of resected prostate tissue in the CMA+ (9.6 mL/g) than in the CMA- group (13.3 mL/g) (P < 0.05). Haematuria on the day of and the day after TURP was also significantly less severe in the CMA+ than in the CMA- group (P < 0.001 and P < 0.05, respectively). The mean microvessel density of resected prostate tissue was significantly less after CMA treatment (P < 0.001).


CONCLUSIONS
CMA given for 1 month before TURP could reduce blood loss to some extent during and after TURP, and this may be related to a decrease in microvessel density.
Ukimura
Osamu
O
Department of Urology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Kyoto 6028566, Japan. ukimuru@ccf.org
Kawauchi
Akihiro
A
Kanazawa
Motohiro
M
Miyashita
Hiroaki
H
Yoneda
Kimihiko
K
Kojima
Munekado
M
Nakanouchi
Tsuneyuki
T
Miki
Tsuneharu
T
D000368:Aged; D000726:Androgen Antagonists / Q000627:therapeutic use*; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D002715:Chlormadinone Acetate / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011300:Preoperative Care / Q000379:methods; D011446:Prospective Studies; D011470:Prostatic Hyperplasia / Q000601:surgery*; D012044:Regression Analysis; D018709:Statistics, Nonparametric; D020728:Transurethral Resection of Prostate / Q000379:methods*
D000726:Androgen Antagonists; D002715:Chlormadinone Acetate