Role of medullary excitatory amino acid receptors in mediating the 10-Hz rhythm in sympathetic nerve discharge of cats.
We tested the hypothesis that excitatory amino acid (EAA)-mediated transmission plays a role in generating the 10-Hz rhythm in sympathetic nerve discharge (SND) of baroreceptor-denervated, urethane-anesthetized cats. Microinjection of either an N-methyl-d-aspartate (NMDA) or non-NMDA receptor antagonist into any one of three medullary regions (lateral tegmental field, rostral, or caudal ventrolateral medulla) essentially eliminated the 10-Hz rhythm in inferior cardiac SND. We conclude that EAA receptors in the medulla are critical for generation of the 10-Hz rhythm.
Barman
Susan M
SM
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA. barman@msu.ed
Orer
Hakan S
HS
Gebber
Gerard L
GL
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D007839:Functional Laterality; D006339:Heart Rate / Q000187:drug effects; D008526:Medulla Oblongata / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D008845:Microinjections / Q000379:methods; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D011806:Quinolinium Compounds / Q000494:pharmacology; D017470:Receptors, Glutamate / Q000378:metabolism*; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology*
D018691:Excitatory Amino Acid Antagonists; D011806:Quinolinium Compounds; D017470:Receptors, Glutamate; D015763:2-Amino-5-phosphonovalerate; C038668:3-nitrobenzothiazolo(3,2-a)quinolinium