[Preparation and surface modification of the magnetic fluid as a targeted drug carrier].
Magnetic fluid containing Fe(3)O(4) as mother nucleus was prepared by chemical coprecipitation and treated with dextran-70 for surface modification. The dextran-70-modified magnetic fluid was reacted with 6-bromohexanoic acid and their chemical stability was studied, with the structure characterized by using laser granulometer, X-ray diffraction, Fourier-transform infrared analysis and transmission electron microscopy. The results showed that the magnetic fluid with surface modification by dextran-70 exhibited high stability in the presence strong alkali or acid. No chemical changes occurred in the magnetic Fe(3)O(4) nucleus surrounded by alkali-treated dextran-70 and the organic chain linked to the surface dextran rendered the reaction to the anti-cancer drug such as mitomycin C possible, suggesting the potential of the preparation as a drug carrier.
Yan
Xi-qing
XQ
Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. yxqdoctor@163.com
Chen
Jian-hai
JH
Jiang
Qing-feng
QF
Liu
Wei
W
Xi
Na
N
Wu
Zhi-shen
ZS
D000977:Antiparasitic Agents / Q000008:administration & dosage; D003911:Dextrans / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis*; D016503:Drug Delivery Systems; D004355:Drug Stability; D005290:Ferric Compounds / Q000737:chemistry; D008280:Magnetics; D016685:Mitomycin / Q000008:administration & dosage / Q000737:chemistry; D013499:Surface Properties
D000977:Antiparasitic Agents; D003911:Dextrans; D004337:Drug Carriers; D005290:Ferric Compounds; D016685:Mitomycin