[A study of action of subinhibiting concentrations of antibiotics on the expression of genes regulating production of pathogenicity factors in Burkholderia cepacia and Pseudomonas aeruginosa].
Described in the paper are the results of a study of differential expression of pathogenicity of B. cepacia and P. aeruginosa in subinhibiting concentrations (SIC) of cyprofloxacyne. While identifying genes expressing differentially in the antibiotic SIC, genes cepR B. cepacia and P. aeruginosa expressing without cyprofloxacyne in the cultivation medium and not expressing in the antibiotic SIC were detected. Finally, involvement of cepR B. cepacia in regulating the pathogenicity expression factors according to "quorum sensing" is under discussion.
Chernukha
M Iu
MIu
Zigangirova
N A
NA
Shaginian
I A
IA
Gintsburg
A L
AL
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016956:Burkholderia cepacia / Q000187:drug effects* / Q000235:genetics / Q000472:pathogenicity; D002939:Ciprofloxacin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000235:genetics / Q000472:pathogenicity; D014774:Virulence / Q000235:genetics
D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin