Human genome -- from pieces to patterns.
A profile of exon-intron lengths in genes shows a normal distribution. This observation suggests that different genes may have portions of their total exon and/or intron lengths in common. In order to explore the common exon-intron structural patterns that may arise due to common lengths across genes, we compared the exon-intron length patterns of annotated human genes. We discovered 1762278 conserved arrangements of exon-intron length across the otherwise unrelated and diverse genomic landscape. The existence of common exon-intron length patterns across unrelated genes suggests for their role of in gene assemblage and human genome design and architecture.
Sakharkar
Meena Kishore
MK
NCSV, MAE, Nanyang Technological University, 639798, Singapore. mmeena@ntu.edu.sg
Kangueane
Pandjassarame
P
Perumal
Bagavathi S
BS
Chow
Vincent Tak Kwong
VT
Sorscher
Eric
E
Sakharkar
Kishore R
KR
Hill
Aubrey
A
D001483:Base Sequence; D005091:Exons / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D007438:Introns / Q000235:genetics*; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA