Combination of boron and gadolinium compounds for neutron capture therapy. An in vitro study.
In neutron capture therapy, the therapeutic effect of the boron compound is based on alpha particles produced by the B(n, alpha) reaction while with the gadolinium compound the main radiation effect is from gamma rays derived from the Gd(n, gamma) reaction. The uptake and distribution within the tumor may be different among these compounds. Thus, the combination of the boron and gadolinium compounds may be beneficial for enhancing the radiation dose to the tumor. Chinese hamster fibroblast V79 cells were used. For the neutron targeting compounds, 10B (BSH) at 0, 5, 10, and 15 ppm, and 157Gd (Gd-BOPTA) at 0, 800, 1600, 2400, 3200, and 4800 ppm, were combined. The neutron irradiation was performed with thermal neutrons for 30 min. (neutron flux: 0.84 x 10(8) n/cm2/s in free air). The combination of the boron and gadolinium compounds showed an additive effect when the gadolinium concentration was lower than 1600 ppm. This additive effect decreased as a function of gadolinium concentration at 2400 ppm and resulted in no additive effect at more than 3200 ppm of gadolinium. In conclusion, the combination of the boron and gadolinium compounds can enhance the therapeutic effect with an optimum concentration ratio. When the gadolinium concentration is too high, it may weaken the boron neutron capture reaction due to the high cross-section of gadolinium compound against neutrons.
Matsumura
A
A
Dept. of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Japan. matsumur@md.tsukuba.ac.jp
Zhang
T
T
Nakai
K
K
Endo
K
K
Kumada
H
H
Yamamoto
T
T
Yoshida
F
F
Sakurai
Y
Y
Yamamoto
K
K
Nose
T
T
D000818:Animals; D001895:Boron / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D006224:Cricetinae; D005347:Fibroblasts; D005682:Gadolinium / Q000494:pharmacology*; D017247:Neutron Capture Therapy / Q000295:instrumentation* / Q000379:methods*
D005682:Gadolinium; D001895:Boron