Mycobacterium marinum with different responses to second-generation tetracyclines.
BACKGROUND
Persistent cutaneous infections with Mycobacterium marinum can follow exposure of injured skin to contaminated water or fish, and can be treated with second-generation tetracyclines in addition to other antimicrobials. Due to the rarity of this infection, there are few data comparing the different treatment alternatives.


METHODS
We report a patient with culture-proven M. marinum who was treated with two different second-generation tetracyclines.


RESULTS
Our patient failed a 4-week trial of doxycycline, but responded rapidly to minocycline.


CONCLUSIONS
This case suggests that, despite a similar mechanism, pharmacokinetics, and even sensitivity, these two agents may differ in their effectiveness against strains of M. marinum.
Cummins
Deborah L
DL
Department of Dermatology, Johns Hopkins, Baltimore, Maryland 21287-0900, USA.
Delacerda
Davi
D
Tausk
Francisco A
FA
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004318:Doxycycline / Q000627:therapeutic use*; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D008297:Male; D008911:Minocycline / Q000627:therapeutic use*; D009165:Mycobacterium Infections, Nontuberculous / Q000175:diagnosis / Q000188:drug therapy*; D019910:Mycobacterium marinum / Q000302:isolation & purification*; D012867:Skin / Q000473:pathology
D000900:Anti-Bacterial Agents; D008911:Minocycline; D004318:Doxycycline