title: Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica.
abstract: [structure: see text] Analysis of the fermentation broth of a strain of the marine actinomycete Salinispora tropica has led to the isolation of two unprecedented macrolides, sporolides A (1) and B (2). The structures and absolute stereochemistries of both metabolites were elucidated using a combination of NMR spectroscopy and X-ray crystallography.
authors.affiliation: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92093-0204, USA.
authors.forename: Greg O
authors.initials: GO
authors.lastname: Buchanan
authors.forename: Philip G
authors.initials: PG
authors.lastname: Williams
authors.forename: Robert H
authors.initials: RH
authors.lastname: Feling
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Kauffman
authors.forename: Paul R
authors.initials: PR
authors.lastname: Jensen
authors.forename: William
authors.initials: W
authors.lastname: Fenical
mesh_terms: D039903:Actinobacteria / Q000737:chemistry*; D018360:Crystallography, X-Ray; D016984:Enterococcus faecium / Q000187:drug effects; D006801:Humans; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D008386:Marine Biology; D016106:Methicillin Resistance / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013211:Staphylococcus aureus / Q000187:drug effects; D014407:Tumor Cells, Cultured; D020713:Vancomycin Resistance / Q000187:drug effects
chemical_list: D018942:Macrolides; C509191:sporolide A