Diffuse vascular damage in a transplanted kidney: an indication for nuclear magnetic resonance?
Vascular lesions are an increasing challenge after renal transplantation due to the wider indications for recipients and acceptance criteria for donors. Diagnostic approach and prognostic interpretation are still matter of controversy. The case reported herein may summarize some of the issues in this regard. A 54-year-old woman, on renal replacement therapy since 1974, and a kidney graft recipient from 1975 to 1999, received a second graft in 2001. The donor age was 65 years (cold ischemia 22 hours; two mismatches). The early posttransplant follow-up was characterized by delayed graft function, hypertension, and diabetes. During the initial hypertension workup, renal graft ultrasound (US) Doppler demonstrated increased vascular resistances, stable over time (resistance index 0.74 to 0.77); renal scintiscan displayed homogeneously parenchymoa and angio-magnetic resonance imaging (MRI), an homogeneous parenchymal vascularization. Initial immunosuppression with tacrolimus and steroids was modulated by adding mycophenolate mofetil to taper tacrolimus (to reduce nephrotoxicity and hypertension). Despite this, kidney function slowly deteriorated; serum creatinine reached 3 to 3.5 mg/dL by the second year. After a severe hypertensive crisis with unchanged scintiscan and US doppler examinations, angio-MRI revealed the almost complete disappearance of parenchymal enhancement beyond the lobar arteries. A renal biopsy confirmed the severe vascular damage. The patient was switched to rapamycine and a low-dose of an angiotension converting enzyme (ACE) inhibitor. She did relatively well (serum creatinine 2.2 to 3 mg/dL) for 6 months, when rapid functional impairment forced her to restart hemodialysis. This case, almost paradigmatic of the problems occurring when the rigid vasculature of long-term dialysis patients is matched with "marginal kidneys," suggests that MRI may be a sensible good to define vascular damage in the grafted kidney.
Burdese
M
M
Department of Internal Medicine, University of Turin, Bramante 88, 10126 Turin, Italy.
Consiglio
V
V
Mezza
E
E
Savio
D
D
Guarena
C
C
Rossetti
M
M
Messina
M
M
Soragna
G
G
Suriani
C
C
Rabbia
C
C
Segoloni
G P
GP
Piccoli
G B
GB
D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000473:pathology*; D018810:Magnetic Resonance Angiography; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged; D012077:Renal Artery / Q000473:pathology*; D012079:Renal Circulation; D012086:Reoperation