title: Cervimycin A-D: a polyketide glycoside complex from a cave bacterium can defeat vancomycin resistance.
abstract: Cervimycins A-D are novel polyketide glycosides with significant activity against multi-drug-resistant staphylococci and vancomycin-resistant enterococci. They are produced by a strain of Streptomyces tendae, isolated from an ancient cave. The structures of the cervimycins were determined by performing extensive NMR and chemical degradation studies. All cervimycins have a common tetracyclic polyketide core that is substituted with unusual di- and tetrasaccharide chains, composed exclusively of trideoxysugars; however, they differ in the acetyl and carbamoyl ring substituent and in the highly unusual terminal methylmalonyl and dimethylmalonyl residues.
authors.affiliation: Leibniz Institute for Natural Products Research and Infection Biology, HKI, Beutenbergstrasse 11a, 07745 Jena, Germany.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Herold
authors.forename: Friedrich A
authors.initials: FA
authors.lastname: Gollmick
authors.forename: Ingrid
authors.initials: I
authors.lastname: Groth
authors.forename: Martin
authors.initials: M
authors.lastname: Roth
authors.forename: Klaus-Dieter
authors.initials: KD
authors.lastname: Menzel
authors.forename: Ute
authors.initials: U
authors.lastname: Möllmann
authors.forename: Udo
authors.initials: U
authors.lastname: Gräfe
authors.forename: Christian
authors.initials: C
authors.lastname: Hertweck
mesh_terms: D001419:Bacteria / Q000737:chemistry* / Q000145:classification / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D020713:Vancomycin Resistance / Q000187:drug effects*
chemical_list: D006027:Glycosides