[Paget's disease, workup and monitoring].
Paget's disease is a progressive bone disease, characterized by bone hypertrophy and increased bone resorption. The pain and deformity that characterize its clinical course are not simple to assess, but it has a characteristic radiographic appearance. In most cases, treatment can be monitored through biological markers of bone turnover. Total alkaline phosphatase is the best marker and measurement of collagen breakdown products is useful in difficult cases. The goal of treatment is the normalization of these biological markers, to prevent complications of the disease.
Roux
Christian
C
Institut de rhumatologie, Hôpital Cochin Université René Descartes, 27, rue du Faubourg St Jacques, Paris. christian.roux@cch.ap-hop-paris.fr
D000469:Alkaline Phosphatase / Q000097:blood / Q000378:metabolism; D015415:Biomarkers; D001862:Bone Resorption; D003937:Diagnosis, Differential; D018450:Disease Progression; D005500:Follow-Up Studies; D006801:Humans; D010001:Osteitis Deformans / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D015675:Osteocalcin / Q000378:metabolism; D011379:Prognosis; D011788:Quality of Life; D011859:Radiography; D011877:Radionuclide Imaging; D012008:Recurrence; D013997:Time Factors
D015415:Biomarkers; D015675:Osteocalcin; D000469:Alkaline Phosphatase