[Regulation of cell adhesion by the cadherin cytoplasmic domain].
Juxtacrine cell interactions associated to cadherin-mediated cell-cell adhesion play a major role in the organization and homeostasis of tissues. Here, we review the intracellular molecules and regulations controlling the formation of cell-cell contacts initiated by homophilic interactions of cadherin ectodomain. These regulations involve proteins associated to cadherin cytoplasmic tail, named catenins, their association to the actin cytoskeleton and the stability of these complexes at the cell membrane. The underlying molecular mechanisms, which participate in the formation of dynamic cell-cell contacts, are intensively investigated.
Gavard
Julie
J
INSERM U440/UPMC, Signalisation et Différenciation dans les Systèmes Nerveux et Musculaire, Institut du Fer-à-Moulin, Paris, France.
Marthiens
Véronique
V
Monnet
Céline
C
Boscher
Cécile
C
Lambert
Mireille
M
Mège
René-Marc
RM
D000199:Actins / Q000502:physiology; D000818:Animals; D015820:Cadherins / Q000737:chemistry / Q000502:physiology*; D002448:Cell Adhesion / Q000502:physiology*; D002450:Cell Communication / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology; D006706:Homeostasis; D006801:Humans
D000199:Actins; D015820:Cadherins