title: 6-Aryl-4-methylsulfanyl-2H-pyran-2-one-3-carbonitriles as PPAR-gamma activators.
abstract: Various 6-aryl-3-cyano/methoxycarbonyl-4-methylsulfanyl-2H-pyran-2-ones have been synthesized as a potential substitute of 2,4-thiazolidinedione head group to express potent PPAR-gamma transactivation response. Some of the screened compounds have shown promising PPAR-gamma agonistic activity.
authors.affiliation: Molecular and Structural Biology Division, Central Drug Research Institute, Lucknow 226001, India.
authors.forename: Ashoke
authors.initials: A
authors.lastname: Sharon
authors.forename: Ramendra
authors.initials: R
authors.lastname: Pratap
authors.forename: Rit
authors.initials: R
authors.lastname: Vatsyayan
authors.forename: Prakas R
authors.initials: PR
authors.lastname: Maulik
authors.forename: Uma
authors.initials: U
authors.lastname: Roy
authors.forename: Atul
authors.initials: A
authors.lastname: Goel
authors.forename: Vishnu Ji
authors.initials: VJ
authors.lastname: Ram
mesh_terms: D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D047495:PPAR gamma / Q000819:agonists / Q000187:drug effects*; D011714:Pyrans / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D008024:Ligands; D009570:Nitriles; D047495:PPAR gamma; D011714:Pyrans