title: A comparative study of the utility of two superdisintegrants in microcrystalline cellulose pellets prepared by extrusion-spheronization.
abstract: This study evaluated the utility of including superdisintegrants (croscarmellose sodium or sodium starch glycolate) in microcrystalline cellulose extrusion-spheronization pellets as a means of increasing the dissolution rate of poorly water-soluble drugs. The model drug was hydrochlorothiazide, with water or water/ethanol as wetting agent for pellet preparation. Neither disintegrant had significant effects on pellet morphology, flow properties or mechanical resistance. Neither disintegrant caused disintegration of the pellet in drug dissolution medium. Nevertheless, the disintegrants afforded a modest increase in drug dissolution rate, attributable to the observed increase in pellet micropore volume. Drug dissolution rate was slightly higher in pellets prepared with sodium starch glycolate, probably because of this disintegrant's higher swelling capacity.
authors.affiliation: Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain.
authors.forename: Consuelo
authors.initials: C
authors.lastname: Souto
authors.forename: Alberto
authors.initials: A
authors.lastname: Rodríguez
authors.forename: Silvia
authors.initials: S
authors.lastname: Parajes
authors.forename: Ramón
authors.initials: R
authors.lastname: Martínez-Pacheco
mesh_terms: D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry*; D003460:Crystallization; D004337:Drug Carriers / Q000737:chemistry*; D004343:Drug Implants; D010316:Particle Size; D016062:Porosity; D012995:Solubility; D013213:Starch / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D004343:Drug Implants; D002482:Cellulose; D013213:Starch; C048390:sodium starch glycolate; D002266:Carboxymethylcellulose Sodium