[Antioxidant properties of statins].
Statins block expression of protein subunits of Gi-proteins (p22phox and gp91phox) which determine oxidase activity of NADPH oxidases and expression of GTP-ase (NADPH activator). This leads to suppression of activity of prooxidant enzyme systems (NADPH oxidase, xanthine oxidase, oxidase activity of endothelial NO-synthase) and diminishment of production of most aggressive free radicals -- superoxide anion and peroxinitrite. Hyperproduction of these radicals is associated with lowering of nitric oxide (NO) level and augmented NO destruction, the state of oxidative stress and endothelial dysfunction. Statins increase expression of enzymes with antioxidant properties (catalases, paroxonases), augment resistance of low density lipoproteins to oxidation, decrease take up of oxidized low density lipoproteins by monocytes and differentiation of monocytes into macrophages at the account of suppression of cellular scavenger receptor CD36 gene expression. Thus statins are powerful antioxidants.
Drinitsina
S V
SV
Zateĭshchikov
D A
DA
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism*; D020558:GTP Phosphohydrolases / Q000096:biosynthesis; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D008562:Membrane Glycoproteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D026901:Membrane Transport Proteins / Q000096:biosynthesis; D000074662:NADPH Oxidase 2; D019255:NADPH Oxidases / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D010750:Phosphoproteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis
D000975:Antioxidants; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D010750:Phosphoproteins; C056558:CYBB protein, human; D000074662:NADPH Oxidase 2; D019255:NADPH Oxidases; C086986:CYBA protein, human; D020558:GTP Phosphohydrolases