title: Preparation and electrophilic cyclization of multisubstituted dienamides leading to cyclic iminoethers.
abstract: Stereodefined multisubstituted dienamides could be concisely prepared in high yields by direct addition of 1-lithiobutadiene derivatives to both N-aryl and N-alkyl isocyanates. Electrophilic cyclization of these dienamides was achieved to generate substituted cyclic iminoethers in excellent yields with perfect selectivity. When treated with 12 N aqueous HCl, dienamides underwent efficient and selective electrophilic cyclization to afford cyclic imidate derivatives. When treated with NBS, monobrominated or double-brominated cyclic iminoethers were formed.
authors.affiliation: Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China.
authors.forename: Congyang
authors.initials: C
authors.lastname: Wang
authors.forename: Jiang
authors.initials: J
authors.lastname: Lu
authors.forename: Guoliang
authors.initials: G
authors.lastname: Mao
authors.forename: Zhenfeng
authors.initials: Z
authors.lastname: Xi