title: GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer.
abstract: Little is known about genetic risk factors for colorectal cancer. We assessed the association between polymorphisms in two genes involved in DNA repair of oxidative stress, GPX and OGG1, and risk of colorectal carcinoma or adenomas. We studied 166 cases with adenocarcinoma, 974 with adenomas and 397 controls recruited from the Norwegian cohort NORCCAP. No associations were found between the polymorphism GPX Pro198Leu and risk of colorectal adenomas or carcinomas. Carriers of the variant allele OGG1 Ser326Cys polymorphism had a lowered risk of colorectal cancer, OR=0.56 (95% confidence interval 0.33-0.95), while no association were found with risk of adenomas. This indicates that a low repair capacity of oxidative DNA damage may not be a risk factor for development of colorectal adenomas or carcinoma.
authors.affiliation: National Institute of Occupational Health, Copenhagen, Denmark.
authors.forename: Rikke
authors.initials: R
authors.lastname: Hansen
authors.forename: Mona
authors.initials: M
authors.lastname: Saebø
authors.forename: Camilla Furu
authors.initials: CF
authors.lastname: Skjelbred
authors.forename: Bjørn Andersen
authors.initials: BA
authors.lastname: Nexø
authors.forename: Per Christian
authors.initials: PC
authors.lastname: Hagen
authors.forename: Günther
authors.initials: G
authors.lastname: Bock
authors.forename: Inger Marie
authors.initials: IM
authors.lastname: Bowitz Lothe
authors.forename: Egil
authors.initials: E
authors.lastname: Johnson
authors.forename: Steinar
authors.initials: S
authors.lastname: Aase
authors.forename: Inger-Lise
authors.initials: IL
authors.lastname: Hansteen
authors.forename: Ulla
authors.initials: U
authors.lastname: Vogel
authors.forename: Elin H
authors.initials: EH
authors.lastname: Kure
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology* / Q000235:genetics*; D000236:Adenoma / Q000209:etiology / Q000235:genetics*; D000368:Aged; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000209:etiology / Q000235:genetics*; D004249:DNA Damage; D045647:DNA Glycosylases / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005979:Glutathione Peroxidase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009664:Norway; D018384:Oxidative Stress; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D005979:Glutathione Peroxidase; D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human