title: Polymer micelle with cross-linked ionic core.
abstract: This work reports the design of polymer micelles with cross-linked ionic cores that display high stability. Block ionomer complexes were utilized as a micellar template for the synthesis of the cross-linked micelles. Such micelles represent hydrophilic nanospheres of core-shell morphology. The core comprises a network of the cross-linked polyanions, which is surrounded by the shell of hydrophilic PEO chains.
authors.affiliation: Department of Pharmaceutical Sciences and the Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 985830 Nebraska Medical Center, Omaha, NE 68198-5830, USA. tbronich@unmc.edu
authors.forename: Tatiana K
authors.initials: TK
authors.lastname: Bronich
authors.forename: Paul A
authors.initials: PA
authors.lastname: Keifer
authors.forename: Luda S
authors.initials: LS
authors.lastname: Shlyakhtenko
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Kabanov
mesh_terms: D002118:Calcium / Q000737:chemistry; D002413:Cations, Divalent; D003432:Cross-Linking Reagents / Q000737:chemistry; D016503:Drug Delivery Systems; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry*; D019904:Polymethyl Methacrylate / Q000737:chemistry*
chemical_list: D002413:Cations, Divalent; D003432:Cross-Linking Reagents; D008823:Micelles; D011092:Polyethylene Glycols; D019904:Polymethyl Methacrylate; D002118:Calcium