Convergent synthesis of a complex oxime library using chemical domain shuffling.
[reaction: see text] The synthesis of a complex hybrid oxime library is reported utilizing convergent ligation of alkoxyamine and carbonyl monomers via "chemical domain shuffling". Initial biological screening of the library against human small cell lung carcinoma (A549) cells led to the identification of a novel hybrid dimer in contrast to the corresponding monomeric compounds which were found to be inactive.
Su
Shun
S
Department of Chemistry and Center for Chemical Methodology and Library Development, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.
Acquilano
Dayle E
DE
Arumugasamy
Jeevanandam
J
Beeler
Aaron B
AB
Eastwood
Erin L
EL
Giguere
Joshua R
JR
Lan
Ping
P
Lei
Xiaoguang
X
Min
Geanna K
GK
Yeager
Adam R
AR
Zhou
Ya
Y
Panek
James S
JS
Snyder
John K
JK
Schaus
Scott E
SE
Porco
John A
JA
D020650:Combinatorial Chemistry Techniques; D007202:Indicators and Reagents; D015394:Molecular Structure; D010091:Oximes / Q000138:chemical synthesis* / Q000737:chemistry*
D007202:Indicators and Reagents; D010091:Oximes