Isolated Rosai Dorfman disease of the central nervous system presenting as dural-based and intraparenchymal lesions.
OBJECTIVE
To report three patients with isolated Rosai Dorfman disease of the central nervous system.


METHODS
We report two patients with dural-based lesions diagnosed imageologically as meningiomas, and one patient with multiple intraparenchymal lesions diagnosed imageologically as lymphoma. Two patients were males and one was female. All were above 35 years of age with no nodal or other system involvement. The diagnosis was established on surgically excised masses during histopathology. One patient died due to unrelated causes 10 years later and the other two are symptom-free at 21.5- and 11.5-year-follow-up.


CONCLUSIONS
Awareness of the entity and consideration in the differential diagnosis of dural-based/intraparenchymal lesions is necessary for diagnosis and prognosis.
Sundaram
C
C
Department of Pathology, Nizam's Institute of Medical Sciences, Hyderabad, India. challa_sundaram@yahoo.com
Uppin
S G
SG
Prasad
B C M
BC
Sahu
B P
BP
Devi
M U
MU
Prasad
V S S V
VS
Purohit
A K
AK
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D003937:Diagnosis, Differential; D004388:Dura Mater / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006644:Histiocytes / Q000276:immunology / Q000473:pathology; D015618:Histiocytosis, Sinus / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D008223:Lymphoma / Q000175:diagnosis; D008264:Macrophages / Q000276:immunology / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008579:Meningioma / Q000175:diagnosis; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D011379:Prognosis; D009418:S100 Proteins / Q000378:metabolism; D014057:Tomography, X-Ray Computed
D009418:S100 Proteins