title: Impact of pretransplant dialysis on early graft function in pediatric kidney recipients.
abstract: Delayed graft function (DGF) is a frequent complication of kidney transplantation (KT) that may affect both short- and long-term graft outcome. It has been reported that pretransplantation peritoneal dialysis was correlated with a better recovery of graft function than hemodialysis in adult kidney recipients. However, the effect of pretransplantation dialysis mode (PDM) seemed to be unclear on the early outcome of KT in pediatric recipients. In this study, the potential impact of PDM on early graft function was evaluated in 174 pediatric patients who underwent KT by using cadaveric donors. The primary outcome parameter was the time to reach a serum creatinine (SCr) level 50% of the pretransplantation value [T(1/2(SCr))], while DGF was defined as a T(1/2(SCr)) >3 days after KT (n = 40). By stratifying kidney recipients for normal function graft or DGF, this latter group showed a significantly higher body weight (BW) on the day of KT (P = 0.014), body surface area (BSA) (P = 0.005), warm ischemia time (WIT) (P = 0.022), early SCr on the day 1 after KT (P < 0.001), and T(1/2(SCr)) (P < 0.001), whereas lower urine volume (UV) collected in the first 24 h after KT (P < 0.001) and fluid load (P < 0.001) occurred. Univariate exponential correlation that was carried out between T(1/2(SCr)) and all the other variables had shown a better value than the linear correlation for BW (R(2) = 0.28 vs. R(2) = 0.04), BSA (R(2) = 0.29 vs. R(2) = 0.03), and SCr (R(2) = 0.51 vs. R(2) = 0.28). In a multivariate regression analysis performed by entering T(1/2(SCr)) as dependent variable and following a forward stepwise method, cold ischemia time (CIT) (P = 0.027) but not PDM (P = 0.195) reached significance. In a Cox regression analysis carried out with T(1/2(SCr)) as dependent variable, neither CIT nor PDM gained significance. This study suggests that PDM does not affect early graft function in pediatric kidney recipients.
authors.affiliation: Department of Transplantation, S. Martino University Hospital, Genoa, Italy.
authors.forename: Iris
authors.initials: I
authors.lastname: Fontana
authors.forename: Gregorio
authors.initials: G
authors.lastname: Santori
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Ginevri
authors.forename: Marco
authors.initials: M
authors.lastname: Beatini
authors.forename: Massimo
authors.initials: M
authors.lastname: Bertocchi
authors.forename: Laura
authors.initials: L
authors.lastname: Bonifazio
authors.forename: Luca
authors.initials: L
authors.lastname: Saltalamacchia
authors.forename: Davide
authors.initials: D
authors.lastname: Ghinolfi
authors.forename: Francesco
authors.initials: F
authors.lastname: Perfumo
authors.forename: Umberto
authors.initials: U
authors.lastname: Valente
mesh_terms: D000293:Adolescent; D002648:Child; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood; D015925:Cryopreservation; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D016030:Kidney Transplantation; D015999:Multivariate Analysis; D010530:Peritoneal Dialysis; D011184:Postoperative Period; D011300:Preoperative Care; D016016:Proportional Hazards Models; D006435:Renal Dialysis; D013997:Time Factors
chemical_list: D003404:Creatinine