[Study of toxicity on male reproductive system of mice induced by SO2 inhalation].
OBJECTIVE
In this paper, toxicity of SO2 on male reproductive system of mice was studied.


METHODS
40 mice were divided to 4 groups (10/group): a group for control, the other 3 groups for SO2 inhalation (28, 56, 112mg/m3), 4h/d, 7d.


RESULTS
The activities of GST and G-6-PD, as well as the content of GSH decreased significantly with SO2 increased. The content of MDA increased evidently with SO2 increased.


CONCLUSIONS
SO2 can influence GSH oxidation-deoxidation system and cause DNA damage in male reproductive system of mice.
Zhang
Bo
B
The Biology Department of College of Arts and Sciences of Beijing Union Unversity, Beijing 100083, China.
Liu
Cheng-yun
CY
Meng
Zi-qiang
ZQ
D000818:Animals; D004249:DNA Damage / Q000187:drug effects*; D005854:Germ Cells / Q000187:drug effects*; D005978:Glutathione / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D019570:Inhalation Exposure; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010084:Oxidation-Reduction / Q000187:drug effects; D013458:Sulfur Dioxide / Q000633:toxicity*; D013737:Testis / Q000187:drug effects / Q000378:metabolism*
D013458:Sulfur Dioxide; D005982:Glutathione Transferase; D005978:Glutathione