Genetic variability of principal neutralizing determinants on HIV-1 gp41 and its correlation with subtypes.
Several neutralizing determinants have been identified on HIV-1 envelope glycoprotein gp41: LGIWGCSGKLIC (HXB2: aa593-604), ELDKWA (aa662-667), NWFDIT (aa671-676), and ERDRDR (aa739-744). Restricted mutations were observed on these epitopes. In this study, the genetic variability of these neutralizing determinants in 3799 isolates from different M-group subtypes (A, B, C, D, F, G, H, CRF01_AE and CRF02_AG) and O group was analyzed. Many variants were found to be closely correlated with certain subtypes. These subtype-related variants could be recruited into the subtype identification and subtype-specific vaccine development.
Dong
Xiao-Nan
XN
Laboratory of Immunology, Department of Biology, Tsinghua University, Protein Science Laboratory of MOE, Beijing 100084, PR China. xndong00@mails.tsinghua.edu.cn
Ying
Jian
J
Wu
Yi
Y
Chen
Ying-Hua
YH
D020816:Amino Acid Motifs; D014644:Genetic Variation; D015700:HIV Envelope Protein gp41 / Q000032:analysis / Q000235:genetics / Q000276:immunology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics / Q000276:immunology*; D006801:Humans; D016056:Immunodominant Epitopes / Q000032:analysis / Q000235:genetics / Q000276:immunology*; D009154:Mutation; D012703:Serotyping
D015700:HIV Envelope Protein gp41; D016056:Immunodominant Epitopes