Erythromycin dose of 70 mg accelerates gastric emptying as effectively as 200 mg in the critically ill.
OBJECTIVE
To compare the effectiveness of 70-mg and 200-mg doses of intravenous erythromycin in improving gastric emptying in critically ill patients.


METHODS
Gastric emptying was measured on consecutive days; day 1 (pre-treatment), day 2 (post-treatment) after an intravenous infusion of either 70 or 200 mg erythromycin or saline placebo (0.9%), in a randomized double-blind fashion.


METHODS
Mixed medical/surgical intensive care unit, tertiary referral.


METHODS
Thirty-five randomly selected, mechanically ventilated, enterally fed critically ill patients (median APACHE II score 19 on admission).


METHODS
On day 2 either 70 or 200 mg erythromycin or saline was administered intravenously over 20 min.


RESULTS
Gastric emptying was measured using the [13C]octanoic acid breath test. The gastric emptying coefficient (GEC) and half-emptying time (t1/2) were calculated from the area under the 13CO2-recovery curve. Pre-treatment gastric emptying measurements were similar in all three patient groups. Treatment with both doses of erythromycin significantly reduced the gastric t1/2: 70 mg, 98 min (IQR 88-112); 200 mg, 86 min (75-104); vs. placebo, 122 min (102-190) (p<0.05). The GEC was higher with both doses of erythromycin: 70 mg, 3.8 (3.3-4.0); 200 mg, 4.0 (3.6-4.2); vs. placebo, 2.9 (2.5-3.7) (p<0.05). There was no difference in gastric emptying post-treatment between the two doses of erythromycin. The effect of erythromycin was greatest in patients with delayed gastric emptying.


CONCLUSIONS
Treatment with 70 and 200 mg intravenous erythromycin are equally effective in accelerating gastric emptying in the critically ill.
Ritz
Marc A
MA
Department of Gastrointestinal Medicine, Royal Adelaide Hospital, 5000, Adelaide, SA, Australia.
Chapman
Marianne J
MJ
Fraser
Robert J
RJ
Finnis
Mark E
ME
Butler
Ross N
RN
Cmielewski
Patricia
P
Davidson
Geoffrey P
GP
Rea
Deborah
D
D000328:Adult; D000368:Aged; D001944:Breath Tests; D003422:Critical Care; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004750:Enteral Nutrition; D004917:Erythromycin / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007262:Infusions, Intravenous; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged
D005765:Gastrointestinal Agents; D004917:Erythromycin