Nucleic acid aptamers in therapeutic anticoagulation. Technology, development and clinical application.
The evolution of anticoagulant therapy for the prevention and treatment of thrombotic disorders has progressed at a relatively modest pace considering the scope of the problem and our current understanding of platelet biology, coagulation proteases, and vascular science as they apply to protective haemostasis and pathologic thrombosis. Recent observations, dedicated to cellular-based models of coagulation, provide fundamental constructs, mechanistic clarity, and potentially unparalleled opportunity for accelerating the development and wide-scale clinical use of safe, effective, regulatable and patient-specific therapies. The following review introduces a novel domain of anticoagulant therapy referred to as aptamers (derived from the Latin aptus - to fit), considering their history, development, and potential application in patient care arenas.
Becker
Richard C
RC
Cardiovascular Thrombosis Research Center, Duke Clinical Research Institute, 2400 Pratt Street, Room 0311 Terrace Level, Durham, North Carolina 27715, USA. Becke021@mc.duke.edu
Rusconi
Christopher
C
Sullenger
Bruce
B
D000925:Anticoagulants / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D001483:Base Sequence; D001709:Biotechnology; D001777:Blood Coagulation / Q000187:drug effects; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D015949:Factor IXa / Q000037:antagonists & inhibitors / Q000378:metabolism; D015942:Factor VIIa / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008954:Models, Biological; D009841:Oligonucleotides / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D011485:Protein Binding; D013917:Thrombin / Q000037:antagonists & inhibitors / Q000378:metabolism; D013927:Thrombosis / Q000188:drug therapy / Q000517:prevention & control
D000925:Anticoagulants; D009841:Oligonucleotides; D015942:Factor VIIa; D015949:Factor IXa; D013917:Thrombin