title: [Macrophage activation syndrome after treatment with infliximab for fistulated Crohn's disease].
abstract: BACKGROUND
  Macrophage activation syndrome has never been reported as an adverse effect of infliximab.
  
  
  METHODS
  Treatment with infliximab was prescribed for a 37-year-old man with fistulated Crohn's disease unresponsive to azathioprine. Three months after the last injection, he developed macrophagic activation syndrome, with febrile pancytopenia, hyperferritinemia, hypertriglyceridemia and an activated cephalin time twice the control level.
  
  
  CONCLUSIONS
  Elimination of the known causes of macrophage activation syndrome suggests it is related to the infliximab treatment, but its pathogenesis remains a mystery.
authors.affiliation: Service des maladies digestives et tropicales, Hôpital d'Instruction des Armées Robert Picqué 33998 Bordeaux Armées.
authors.forename: Eric
authors.initials: E
authors.lastname: Chauveau
authors.forename: François
authors.initials: F
authors.lastname: Terrier
authors.forename: Didier
authors.initials: D
authors.lastname: Casassus-Buihle
authors.forename: Xavier
authors.initials: X
authors.lastname: Moncoucy
authors.forename: Bernard
authors.initials: B
authors.lastname: Oddes
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D001778:Blood Coagulation Disorders / Q000139:chemically induced; D003424:Crohn Disease / Q000188:drug therapy*; D005293:Ferritins / Q000097:blood; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D015228:Hypertriglyceridemia / Q000139:chemically induced; D000069285:Infliximab; D008262:Macrophage Activation / Q000187:drug effects*; D008297:Male; D010198:Pancytopenia / Q000139:chemically induced; D010587:Phagocytosis; D013577:Syndrome
chemical_list: D000911:Antibodies, Monoclonal; D005765:Gastrointestinal Agents; D005293:Ferritins; D000069285:Infliximab