Dosage compensation in flies: mechanism, models, mystery.
Dosage compensation involves fine-tuning of gene expression at the level of entire chromosomes. The principles that assure selective targeting of the male X chromosome in Drosophila and the mechanism by which transcription levels are adjusted in a twofold range are still mysterious. We discuss the prevalent models in the context of recent experimental observations.
Straub
Tobias
T
Adolf-Butenandt-Institut, Molekularbiologie, Schillerstrasse 44, 80336 München, Germany.
Dahlsveen
Ina K
IK
Becker
Peter B
PB
D000818:Animals; D004303:Dosage Compensation, Genetic; D004330:Drosophila / Q000235:genetics*; D008957:Models, Genetic; D014960:X Chromosome / Q000235:genetics