Significance of cyclooxygenase 2 and MDR1/P-glycoprotein coexpression in ovarian cancers.
Immunohistochemical analysis of prognostic significance of COX-2 and P-gp expression in ovarian cancers was performed on samples originating from 73 tumors. COX-2-positive cases were shown to demonstrate higher expression of P-gp. The studies demonstrated also that, higher P-gp expression was typical for cases which responded poorly to chemotherapy and for cases with shorter progression-free time. Expression of COX-2 predisposed to a more rapid disease progression. The study documented a relationship between COX-2 and P-gp suggesting that COX-2 inhibitors might investigated in clinical trials as a treatment supplementary to chemotherapy of ovarian cancers.
Surowiak
Paweł
P
Institute of Pathology, Charité Campus Mitte, Humboldt University Berlin, Schumannstr. 20/21, D-10117 Berlin, Germany.
Materna
Verena
V
Denkert
Carsten
C
Kaplenko
Irina
I
Spaczyński
Marek
M
Dietel
Manfred
M
Zabel
Maciej
M
Lage
Hermann
H
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000032:analysis*; D051546:Cyclooxygenase 2 / Q000032:analysis* / Q000502:physiology; D052246:Cyclooxygenase 2 Inhibitors / Q000627:therapeutic use; D015232:Dinoprostone / Q000096:biosynthesis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010051:Ovarian Neoplasms / Q000737:chemistry* / Q000188:drug therapy / Q000401:mortality
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D052246:Cyclooxygenase 2 Inhibitors; D051546:Cyclooxygenase 2; D015232:Dinoprostone