title: Alzheimer's lymphocytes are resistant to ultraviolet B-induced apoptosis.
abstract: In the present pilot investigation, the susceptibility of T-lymphocytes from Alzheimer's disease (AD) subjects (n=22) and aged-matched, non-demented controls (CNT) (n=12) was examined with ultraviolet (UV) B light-induced apoptosis in vitro. The basal apoptotic ratios were similar in both groups. However, the AD lymphocytes displayed significantly (p<0.0001) lower apoptotic levels than those of the CNT lymphocytes at all of the applied UVB exposure doses (100, 200 and 300 mJ/cm(2)). These observations indicate that AD lymphocytes are more resistant than CNT lymphocytes to UVB irradiation.
authors.affiliation: Department of Psychiatry, Albert Szent-Györgyi Center for Medical and Pharmaceutical Sciences, University of Szeged, 6 Semmelweis Street, Szeged H-6725, Hungary. mzana@freemail.hu
authors.forename: Marianna
authors.initials: M
authors.lastname: Zana
authors.forename: Anna
authors.initials: A
authors.lastname: Juhász
authors.forename: Agnes
authors.initials: A
authors.lastname: Rimanóczy
authors.forename: Annamária
authors.initials: A
authors.lastname: Bjelik
authors.forename: Eszter
authors.initials: E
authors.lastname: Baltás
authors.forename: Imre
authors.initials: I
authors.lastname: Ocsovszki
authors.forename: Krisztina
authors.initials: K
authors.lastname: Boda
authors.forename: Botond
authors.initials: B
authors.lastname: Penke
authors.forename: Attila
authors.initials: A
authors.lastname: Dobozy
authors.forename: Lajos
authors.initials: L
authors.lastname: Kemény
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Janka
authors.forename: János
authors.initials: J
authors.lastname: Kálmán
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology*; D000704:Analysis of Variance; D017209:Apoptosis / Q000528:radiation effects*; D016022:Case-Control Studies; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D014466:Ultraviolet Rays / Q000009:adverse effects*