title: 1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: application in the synthesis of potent human melanocortin-4 receptor selective agonists.
abstract: The discovery of 1-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid analogs as potent human melanocortin-4 selective agonists is described.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065-0900, USA. Raman_bakshi@merck.com
authors.forename: Raman K
authors.initials: RK
authors.lastname: Bakshi
authors.forename: Qingmei
authors.initials: Q
authors.lastname: Hong
authors.forename: J T
authors.initials: JT
authors.lastname: Olson
authors.forename: Zhixiong
authors.initials: Z
authors.lastname: Ye
authors.forename: Iyassue K
authors.initials: IK
authors.lastname: Sebhat
authors.forename: David H
authors.initials: DH
authors.lastname: Weinberg
authors.forename: Tanya
authors.initials: T
authors.lastname: MacNeil
authors.forename: Rubana N
authors.initials: RN
authors.lastname: Kalyani
authors.forename: Rui
authors.initials: R
authors.lastname: Tang
authors.forename: William J
authors.initials: WJ
authors.lastname: Martin
authors.forename: Alison
authors.initials: A
authors.lastname: Strack
authors.forename: Erin
authors.initials: E
authors.lastname: McGowan
authors.forename: Constantin
authors.initials: C
authors.lastname: Tamvakopoulos
authors.forename: Randy R
authors.initials: RR
authors.lastname: Miller
authors.forename: Ralph A
authors.initials: RA
authors.lastname: Stearns
authors.forename: Wei
authors.initials: W
authors.lastname: Tang
authors.forename: D Euan
authors.initials: DE
authors.lastname: Maclntyre
authors.forename: Lex H T
authors.initials: LH
authors.lastname: van der Ploeg
authors.forename: Arthur A
authors.initials: AA
authors.lastname: Patchett
authors.forename: Ravi P
authors.initials: RP
authors.lastname: Nargund
mesh_terms: D002264:Carboxylic Acids / Q000494:pharmacology*; D006801:Humans; D008968:Molecular Conformation; D018716:Molecular Mimicry; D011485:Protein Binding / Q000187:drug effects; D044105:Receptor, Melanocortin, Type 4 / Q000819:agonists* / Q000378:metabolism; D013329:Structure-Activity Relationship; D044005:Tetrahydroisoquinolines / Q000737:chemistry*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
chemical_list: D002264:Carboxylic Acids; C470072:MC4R protein, human; D044105:Receptor, Melanocortin, Type 4; D044005:Tetrahydroisoquinolines; D013764:Tetrahydronaphthalenes; C078986:1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid