The surgical treatment of Peyronie's disease: replacement of plaque by free autograft of buccal mucosa.
OBJECTIVE
The aim of this work was the evaluation of clinical results of the use of buccal mucosa for replacement of Peyronie's disease plaque.


METHODS
Twenty-six patients with Peyronie's disease were under observation. All the patients underwent the following investigations before and periodically within 3 years after the treatment: International Index of Erectile Function (IIEF-5), manual examination of plaque, autophotography of erect penis, conventional and power color Doppler sonography of penis, Peno-Brachial Index (PBI) before and its increase (IPBI) after the intracavernous injection of papaverin, Peak Systolic Velocity (PSV), end diastolic velocity (EDV), Resistance Index (RI), Sexual Encounter Profile questions (SEP-2 and SEP-3), measurements of penile length and curvature angle in the phase of rigidity. After stabilization in plaque's development (mean time 2.0+/-0.1 years) the patients underwent a surgery by means of excision of plaque and its replacement by free autograft of buccal mucosa.


RESULTS
After the surgical treatment (with mean follow up observation of 3.2+/-0.1 years) in 24 patients out of 26 (92.3%) the complete straightening of penis occurred, in two (7.7%) cases a residual curvature (<10 degrees) remained, in four patients (15.4%) the shortening of penis (by 1cm) and in two patients (7.7%) a partial reduction of erectile power were observed.


CONCLUSIONS
Buccal mucosa showed high properties of adaptation and revascularization, good anatomical and functional clinical results by replacement of indurative plaque, it kept a stable elasticity without shrinkage; the method is simple and can be recommended for wide use in clinics for surgical treatment of Peyronie's disease.
Shioshvili
Tamaz J
TJ
Department of Urology at State Medical Academy, I. Chavchavadze Ave. 33, 380079 Tbilisi, Georgia, Georgia. iva_shioshvili@yahoo.com
Kakonashvili
Alexander P
AP
D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000637:transplantation*; D010208:Papaverine / Q000008:administration & dosage; D010410:Penile Erection / Q000502:physiology; D010411:Penile Induration / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D019651:Plastic Surgery Procedures / Q000379:methods; D012189:Retrospective Studies; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D018615:Ultrasonography, Doppler, Color; D013521:Urologic Surgical Procedures, Male / Q000379:methods*; D014665:Vasodilator Agents / Q000008:administration & dosage
D014665:Vasodilator Agents; D010208:Papaverine