The antiphospholipid antibody syndrome research in patients with retinal venous occlusion.
BACKGROUND
The antiphospholipid antibody syndrome (APAS) is a condition associated with abnormal thrombosis and the presence of anticardiolipin antibodies (aCL).


METHODS
Thirty-two patients (20 male and 12 female) aged between 29 and 75 years (mean +/- SD: 56.4 +/- 12.34) with retinal venous occlusive disease were studied. All patients with a history of venous occlusive disease within the previous 8 months were included in the study. Diagnoses were made by fundus examination and fundus fluorescein angiography (FFA). Anticardiolipin IgM and IgG antibodies, antinuclear antibodies (ANA), and IL-1beta were investigated in all patients.


RESULTS
Neither aCL-IgM nor aCL-IgG was observed as positive in this group. Only four patients were found to be ANA positive. However, serum levels of IL-1beta were higher than those of controls (p <0.001). Mean IL-1beta was found to be 18.06 +/- 3.39 pg/mL (mean +/- SE), respectively. IL-1beta levels were found to be significantly different from those of controls (2.7 +/- 0.68 pg/mL) (p <0.001). In this study, antiphospholipid antibody positivity was not determined in any patients.


CONCLUSIONS
As a result, IL-1beta level appears higher in retinal venous occlusive disease. This cytokine measurement might be used as a diagnostic indicator for venous occlusive disease.
Ilhan
Fulya
F
Immunology Department, Firat University Medical School, Elazig, Turkey. fulhan23@yahoo.com
Celiker
Ulku
U
Godekmerdan
Ahmet
A
Kan
Emrah
E
D000328:Adult; D000368:Aged; D000792:Angiography; D017153:Antibodies, Anticardiolipin / Q000276:immunology; D016736:Antiphospholipid Syndrome / Q000150:complications*; D002308:Cardiolipins / Q000737:chemistry / Q000276:immunology; D016207:Cytokines / Q000378:metabolism; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000737:chemistry; D007075:Immunoglobulin M / Q000737:chemistry; D007249:Inflammation; D007375:Interleukin-1 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012170:Retinal Vein Occlusion / Q000150:complications*; D013927:Thrombosis; D014652:Vascular Diseases / Q000150:complications
D017153:Antibodies, Anticardiolipin; D002308:Cardiolipins; D016207:Cytokines; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007375:Interleukin-1