Evaluation of computational models for hemolysis estimation.
The potential for mechanical erythrocyte damage, or hemolysis, in heart valves and blood pumps has been estimated using computational fluid dynamics (CFD) analysis, combined with mathematical models of red cell damage mechanisms. To date, these prediction approaches have not been compared with each other in common benchmark cases, nor have they been evaluated in radically different flow geometries. In this study, four test devices, including a hemoresistometer, a spinning disk, a capillary tube, and a concentric cylinder viscometer were hemolysis tested and computationally simulated. A number of existing models were used to predict blood damage and these models were compared with each other and with actual measurement of hemolysis. The study indicates that the effectiveness of blood damage prediction from the existing models is similar and can potentially be improved with the consideration of a proposed repeated flow passage effect. It also indicates that the improved models can be used to more effectively predict blood damage in widely different situations.
Gu
Lei
L
Department of Biomedical Engineering, Cleveland Clinic Lerner College of Medicine-CWRU, Cleveland, Ohio, USA.
Smith
William A
WA
D000818:Animals; D002417:Cattle; D003198:Computer Simulation; D006461:Hemolysis; D008954:Models, Biological