title: Cost-effectiveness of universal childhood hepatitis A vaccination in Chile.
abstract: Hepatitis A is an important public health problem in Chile. Childhood vaccination has reduced hepatitis A rates in several countries, prompting this evaluation of its cost-effectiveness in Chile. Using a Markov model, we project mass vaccination would reduce hepatitis A cases among birth cohort members and their personal contacts >80%. Vaccination costs of US dollars 5.3-6.4 million would be offset by US dollars 9.2-9.4 million reductions in disease costs. Further, approximately 70 fatal infections would be averted and >4600 quality-adjusted life years would be saved. This analysis supports the cost-effectiveness of universal childhood hepatitis A vaccination in Chile.
authors.affiliation: School of Public Health, Faculty of Medicine, University of Chile, Santiago, Chile.
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Valenzuela
authors.forename: R Jake
authors.initials: RJ
authors.lastname: Jacobs
authors.forename: Oscar
authors.initials: O
authors.lastname: Arteaga
authors.forename: Maria S
authors.initials: MS
authors.lastname: Navarrete
authors.forename: Allen S
authors.initials: AS
authors.lastname: Meyerhoff
authors.forename: Bruce L
authors.initials: BL
authors.lastname: Innis
mesh_terms: D002675:Child, Preschool; D002677:Chile / Q000453:epidemiology; D003362:Cost-Benefit Analysis; D017048:Health Care Costs; D006506:Hepatitis A / Q000191:economics / Q000453:epidemiology / Q000517:prevention & control*; D022362:Hepatitis A Vaccines / Q000008:administration & dosage / Q000191:economics*; D017957:Hepatitis A Virus, Human / Q000276:immunology*; D006801:Humans; D017589:Immunization Programs / Q000191:economics*; D007115:Immunization Schedule; D007223:Infant; D014611:Vaccination / Q000191:economics / Q000379:methods
chemical_list: D022362:Hepatitis A Vaccines