HEGESMA: genome search meta-analysis and heterogeneity testing.
CONCLUSIONS
Heterogeneity and genome search meta-analysis (HEGESMA) is a comprehensive software for performing genome scan meta-analysis, a quantitative method to identify genetic regions (bins) with consistently increased linkage score across multiple genome scans, and for testing the heterogeneity of the results of each bin across scans. The program provides as an output the average of ranks and three heterogeneity statistics, as well as corresponding significance levels. Statistical inferences are based on Monte Carlo permutation tests. The program allows both unweighted and weighted analysis, with the weights for each study as specified by the user. Furthermore, the program performs heterogeneity analyses restricted to the bins with similar average ranks.


BACKGROUND
http://biomath.med.uth.gr.
Zintzaras
Elias
E
Department of Biomathematics, University of Thessaly School of Medicine, Larissa 41222, Greece. zintza@med.uth.gr
Ioannidis
John P A
JP
D002874:Chromosome Mapping; D019295:Computational Biology / Q000295:instrumentation* / Q000379:methods*; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D016678:Genome; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008126:Lod Score; D015201:Meta-Analysis as Topic; D009010:Monte Carlo Method; D010375:Pedigree; D012984:Software
D005819:Genetic Markers