title: Patupilone (epothilone B, EPO906) inhibits growth and metastasis of experimental prostate tumors in vivo.
abstract: BACKGROUND
  Microtubule agents appear promising for the treatment of prostate cancer. Patupilone (epothilone B), a highly potent non-taxane microtubule stabilizing agent, was evaluated in models of androgen-independent prostate cancer.
  
  
  METHODS
  Patupilone was administered to athymic mice bearing human prostate cancer xenografts (subcutaneous DU 145 and PC-3M, orthotopic PC-3M).
  
  
  RESULTS
  One 4 mg/kg patupilone administration produced transient regression of DU 145 tumors, while two weekly administrations of 2.5 mg/kg produced stable disease followed by protracted regression, however with more pronounced body weight loss. Taxol (15 mg/kg every other day) weakly inhibited tumor growth, but with less body weight loss. Patupilone (5 mg/kg) produced protracted growth inhibition of subcutaneous PC-3M tumors, with transient body weight loss. In mice with orthotopic PC-3M tumors, 4 or 5 mg/kg/week patupilone impaired primary tumor growth, abrogated metastases and enhanced survival, with only transient body weight loss.
  
  
  CONCLUSIONS
  These data suggest that patupilone holds promise for prostate cancer treatment.
authors.affiliation: Novartis Institutes for BioMedical Research, Oncology Research, Basel, Switzerland.
authors.forename: Terence
authors.initials: T
authors.lastname: O'Reilly
authors.forename: Paul Michael John
authors.initials: PM
authors.lastname: McSheehy
authors.forename: Fritz
authors.initials: F
authors.lastname: Wenger
authors.forename: Marc
authors.initials: M
authors.lastname: Hattenberger
authors.forename: Melanie
authors.initials: M
authors.lastname: Muller
authors.forename: Juliane
authors.initials: J
authors.lastname: Vaxelaire
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Altmann
authors.forename: Markus
authors.initials: M
authors.lastname: Wartmann
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D045744:Cell Line, Tumor; D034261:Epothilones / Q000494:pharmacology*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D017239:Paclitaxel / Q000494:pharmacology; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D034261:Epothilones; D017239:Paclitaxel; C093788:epothilone B