CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis.
The comprehension of the pathogenesis of Trypanosoma cruzi-elicited myocarditis is crucial to delineate new therapeutic strategies aiming to ameliorate the inflammation that leads to heart dysfunction, without hampering parasite control. The augmented expression of CCL5/RANTES and CCL3/MIP-1alpha, and their receptor CCR5, in the heart of T. cruzi-infected mice suggests a role for CC-chemokines and their receptors in the pathogenesis of T. cruzi-elicited myocarditis. Herein, we discuss our recent results using a CC-chemokine receptor inhibitor (Met-RANTES), showing the participation of CC-chemokines in T. cruzi infection and unraveling CC-chemokine receptors as an attractive therapeutic target for further evaluation in Chagas disease.
Marino
A P M P
AP
Laboratório de Autoimunidade e Imuno-regulação, Departamento de Imunologia, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, 21040-900, Brasil.
Silva
A A
AA
Santos
P V A
PV
Pinto
L M O
LM
Gazinelli
R T
RT
Teixeira
M M
MM
Lannes-Vieira
J
J
D000818:Animals; D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002598:Chagas Cardiomyopathy / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D018946:Chemokine CCL5 / Q000031:analogs & derivatives* / Q000627:therapeutic use; D019742:Chemokines, CC / Q000378:metabolism*; D002634:Chemotaxis, Leukocyte / Q000276:immunology; D051379:Mice; D008809:Mice, Inbred C3H; D009205:Myocarditis / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism / Q000469:parasitology; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors*; D014349:Trypanosoma cruzi / Q000276:immunology
D018946:Chemokine CCL5; D019742:Chemokines, CC; C108335:RANTES, Met-; D019707:Receptors, Chemokine