Stereolabile chiral compounds: analysis by dynamic chromatography and stopped-flow methods.
Enantiomerization and diastereomerization reactions of chiral compounds play a major role in all aspects of chemistry spanning a wide bridge from drug development to supramolecular chemistry. Traditionally, these reactions are studied by variable-temperature NMR spectroscopy and chiroptical methods such as polarimetry. However, powerful complimentary methods based on chromatography and electrophoresis have been developed and applied to a variety of stereolabile chiral compounds. This tutorial review explains the principles, applications, and limitations of dynamic chromatography and chromatographic and electrophoretic stopped-flow analysis for the investigation of isomerization reactions of chiral compounds.
Wolf
Christian
C
Department of Chemistry, Georgetown University, Washington DC 20057, USA. cw27@georgetown.edu
D002614:Chelating Agents / Q000737:chemistry*; D002845:Chromatography / Q000379:methods*; D003198:Computer Simulation; D008968:Molecular Conformation; D011083:Polycyclic Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature; D013816:Thermodynamics
D002614:Chelating Agents; D011083:Polycyclic Compounds