title: A simple in vivo atrial fibrillation model of rat induced by transesophageal atrial burst pacing.
abstract: A simple in vivo closed-chest atrial fibrillation (Af) model of rats was developed. Af was reproducibly induced by transesophageal atrial burst pacing for 30 s in each of the pentobarbital-anesthetized rats, whereas the cardiohemodynamic condition as well as the inducibility and duration of Af episode was stable over time. Moreover, the anti-Af effect of the class Ic drug pilsicainide was confirmed in this model, which was essentially the same as those reported previously in other Af animal models and clinical practice. Thus, this new model may become an alternative to current techniques.
authors.affiliation: Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Japan. atsushis@yamanashi.ac.jp
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sugiyama
authors.forename: Akira
authors.initials: A
authors.lastname: Takahara
authors.forename: Sachiko
authors.initials: S
authors.lastname: Honsho
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Keitaro
authors.initials: K
authors.lastname: Hashimoto
mesh_terms: D000818:Animals; D001281:Atrial Fibrillation / Q000209:etiology*; D002304:Cardiac Pacing, Artificial; D004195:Disease Models, Animal; D004562:Electrocardiography; D008012:Lidocaine / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D008012:Lidocaine; C042288:pilsicainide