Antioxidant and detoxifying enzymes in the liver of rats after subchronic inhalation of the mixture of cyclic hydrocarbons.
The activity of antioxidant and detoxifying enzymes, superoxide dismutase (SOD), glutathione peroxidase (GSHPx), glutathione-S-transferase (GST), the SOD isoenzyme patterns and the contents of thiobarbituric acid reactive substances (TBARS), were determined in the livers of male and female rats after subchronic inhalation of mixtures of benzene, cyclohexanone and cyclohexane. Except for decreased GSHPx (with substrate cumene hydroperoxide) and GST activities in female rats, no differences in the activities of antioxidant and detoxifying enzymes and TBARS content occurred. Between the activities of GSHPx and GST was observed an indirect relationship. The activities of GSHPx-cum and GST were influenced by sex.
Holovská
Katarína
K
University of Veterinary Medicine, Komenskeho 73, 041 81 Kosice, Slovakia. holovska@hotmail.com
Sobeková
Anna
A
Holovská
Katarína
K
Lenártová
Viera
V
Javorskỳ
Peter
P
Legáth
Jaroslav
J
Legáth
L'ubomír
L
Maretta
Milan
M
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001554:Benzene / Q000633:toxicity; D001555:Benzene Derivatives / Q000378:metabolism; D003510:Cyclohexanes / Q000633:toxicity; D003512:Cyclohexanones / Q000633:toxicity; D004338:Drug Combinations; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006844:Hydrocarbons, Cyclic / Q000633:toxicity*; D008658:Inactivation, Metabolic; D019570:Inhalation Exposure; D007527:Isoenzymes; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D000975:Antioxidants; D001555:Benzene Derivatives; D003510:Cyclohexanes; D003512:Cyclohexanones; D004338:Drug Combinations; D006844:Hydrocarbons, Cyclic; D007527:Isoenzymes; D017392:Thiobarbituric Acid Reactive Substances; C036468:cyclohexanone; D010088:Oxidoreductases; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; D001554:Benzene; C007164:cumene hydroperoxide