title: Effects of Ibuprofen and High-Voltage Electric Stimulation on Acute Edema Formation After Blunt Trauma to Limbs of Rats.
abstract: Context: Ibuprofen is widely used to manage pain and inflammation after orthopaedic trauma, but its effect on acute swelling has not been investigated. Cathodal high-voltage pulsed current (CHVPC) at 120 pulses per second and 90% of visible motor threshold is known to curb edema formation after blunt trauma to the hind limbs of rats.Objective: To examine the effects of ibuprofen, continuous CHVPC, and simultaneous ibuprofen and CHVPC on acute edema formation after blunt trauma to the hind limbs of rats.Design: Randomized, parallel-group, repeated-measures design.Setting: Laboratory animal facility.Participants: A total of 21 3-month-old Zucker Lean rats (mass = 288 +/- 55 g) were studied.Intervention(s): We assessed the effects of ibuprofen, continuous CHVPC, and simultaneous ibuprofen and CHVPC on acute edema formation after blunt trauma to the hind limbs of rats.Main Outcome Measure(s): Limb volumes were measured immediately before and after trauma and every 30 minutes over the 4 hours of the experiment.Results: Volumes of treated limbs of all 3 experimental groups were smaller (P < .05) than those of untreated limbs, but no treatment was more effective than another.Conclusions: Ibuprofen, CHVPC, and simultaneous ibuprofen and CHVPC effectively curbed edema after blunt injury by roughly 50% relative to untreated but similarly injured control limbs of rats.
authors.affiliation: * Canisius College, Buffalo, NY.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Dolan
authors.forename: Paul
authors.initials: P
authors.lastname: Graves
authors.forename: Chika
authors.initials: C
authors.lastname: Nakazawa
authors.forename: Teresa
authors.initials: T
authors.lastname: Delano
authors.forename: Alan
authors.initials: A
authors.lastname: Hutson
authors.forename: Frank C
authors.initials: FC
authors.lastname: Mendel