title: Is metoclopramide an alternative to tramadol in management of post-operative pain? An experimental study.
abstract: In this study, metoclopramide was compared with other pharmacological agents for preventing post-operative pain. Sixty Sprague-Dawley male rats, weighing 310-345 g were included in the study; 1 cm surgical incision, including skin, facia, and muscle was made to the plantar surface of rear foot of all anaesthetized rats. Rats were randomized into four groups. In group 1 (group S) 2 cm3 saline, in group 2 (group M) 2 cm3 metoclopramide (5 mg/kg) in group 3 (group T) 2 cm3 tramadol (45 mg/kg), in group 4 (group M+T) half doses of group M and group T was given intraperitoneally. Post-operative pain was assessed after 2 h, first and second days of incision. Post-operative pain scores were found to be significantly lower in group M, group T and group M+T when compared with the control group. But there was no significant difference between these groups. We concluded that metoclopramide, with low cost, fewer side-effects and being significantly effective for preventing post-operative pain, can be an alternative to tramadol.
authors.affiliation: First Anaesthesiology Clinic, Ankara Training and Research Hospital, Ministry of Health, Ankara, Turkey. aysegulceyhan@yahoo.com
authors.forename: A
authors.initials: A
authors.lastname: Ceyhan
authors.forename: H
authors.initials: H
authors.lastname: Ustun
authors.forename: K
authors.initials: K
authors.lastname: Altunatmaz
authors.forename: T
authors.initials: T
authors.lastname: Ide
authors.forename: N
authors.initials: N
authors.lastname: Unal
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use; D000818:Animals; D018492:Dopamine Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage / Q000627:therapeutic use*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014147:Tramadol / Q000008:administration & dosage / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000701:Analgesics, Opioid; D018492:Dopamine Antagonists; D014147:Tramadol; D008787:Metoclopramide