title: Clinical significance of Ki-67 labeling index in pituitary macroadenoma.
abstract: The aim of our study was to investigate the correlation of the proliferative activity of pituitary neoplasms with clinical characteristics and recurrences. Tumor specimens were obtained from 44 consecutive patients with pituitary macroadenomas who underwent surgery between July 1998 and August 2003. Specimens were immediately fixed in 10% buffered formalin and then embedded in paraffin. The Ki-67 antigen was assessed by immumohistochemical analysis using the monoclonal antibody. We investigated the correlation of the Ki-67 labeling index with the following clinical and radiological characteristics: sex, age, presence or absence visual field defect, tumor classification, maximal tumor diameter, Hardy's classification, type of tumor, invasiveness, and recurrence. Our study suggests that the clinical characteristics such as visual field defect and recurrence are correlated with the high Ki-67 labeling index. No statistical differences were observed in the Ki-67 labeling index in relation to the following characteristics: sex, age, tumor classification, maximal tumor diameter, Hardy's classification, type of tumor, and invasiveness into the sphenoid sinus or cavernous sinus.
authors.affiliation: Department of Neurosurgery, College of Medicine, Chungnam National University, Daejeon, Korea.
authors.forename: Kyung-Il
authors.initials: KI
authors.lastname: Paek
authors.forename: Seon-Hwan
authors.initials: SH
authors.lastname: Kim
authors.forename: Shi-Hun
authors.initials: SH
authors.lastname: Song
authors.forename: Seung-Won
authors.initials: SW
authors.lastname: Choi
authors.forename: Hyeon-Song
authors.initials: HS
authors.lastname: Koh
authors.forename: Jin-Young
authors.initials: JY
authors.lastname: Youm
authors.forename: Youn
authors.initials: Y
authors.lastname: Kim
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010911:Pituitary Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D011859:Radiography
chemical_list: D019394:Ki-67 Antigen