A perspective on regulation of cell-cell adhesion and epithelial-mesenchymal transition: known and novel.
A number of recent reviews in the field have described many of the known growth factors and signalling pathways that may be involved in regulating epithelial-mesenchymal transitions. This perspective will focus on some aspects of posttranslational regulation of cell-cell adhesion that are less well understood and their potential role in initiating epithelial-mesenchymal transitions. In addition, a potential novel intermediate in the signalling pathway of epithelial-mesenchymal transition will also be described.
Khew-Goodall
Yeesim
Y
Division of Human Immunology, Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, Australia. yeesim.khew-goodall@imvs.sa.gov.au
Wadham
Carol
C
D022005:Adherens Junctions; D000818:Animals; D015820:Cadherins / Q000378:metabolism; D002448:Cell Adhesion; D002450:Cell Communication; D002460:Cell Line; D004285:Dogs; D015536:Down-Regulation; D004847:Epithelial Cells / Q000166:cytology*; D004848:Epithelium / Q000196:embryology*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008648:Mesoderm / Q000378:metabolism*; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D015398:Signal Transduction; D014158:Transcription, Genetic; D014945:Wound Healing
D015820:Cadherins; D017027:Protein Tyrosine Phosphatases