Vascular distribution patterns in monochorionic twin placentas.
Several recent publications have focused on the association between the occurrence of twin-to-twin transfusion syndrome (TTTS) in diamniotic-monochorionic twins and the presence of a number of selected anatomic placental characteristics (distribution of vascular territory, cord insertion, type and number of inter-twin anastomoses). In contrast, the potential importance of the vascular distribution patterns of the individual twins remains to be elucidated. Based on its gross architectural distribution pattern, chorionic vasculature is traditionally described as disperse, magistral or mixed. The aim of this study was (1) to determine the relative prevalence of these vascular distribution patterns in monochorionic twin placentas, and (2) to correlate these patterns with the presence of TTTS and known anatomic placental features linked to TTTS. The placentas of 89 consecutive diamniotic-monochorionic twins (15 with TTTS, 74 without TTTS), examined at Women and Infants Hospital, were studied. Disperse vascular patterns were seen in 53% of twins, and magistral or mixed patterns in 47%. The prevalence of magistral/mixed vascular patterns was significantly higher in TTTS gestations than in non-TTTS gestations (60% versus 44%, P<0.05) and, in TTTS gestations, much higher in donor twins than in recipient twins (87% versus 33%, P<0.005). A strong association was found between the presence of magistral/mixed patterns and marginal/velamentous cord insertion, low number of inter-twin anastomoses, and uneven distribution of the vascular territories. These findings suggest that the magistral/mixed vascular distribution pattern may represent an important placental architectural feature contributing to the complex pathophysiology of TTTS.
De Paepe
M E
ME
Department of Pathology, Women and Infants Hospital and Brown Medical School, 101 Dudley Street, Providence, RI 02905, United States. mdepaepe@wihri.org
DeKoninck
P
P
Friedman
R M
RM
D000650:Amnion / Q000033:anatomy & histology / Q000098:blood supply*; D001163:Arteriovenous Anastomosis / Q000473:pathology; D002823:Chorion / Q000033:anatomy & histology / Q000098:blood supply*; D005260:Female; D005330:Fetofetal Transfusion / Q000473:pathology*; D006801:Humans; D010920:Placenta / Q000033:anatomy & histology / Q000098:blood supply*; D011247:Pregnancy; D011379:Prognosis; D014427:Twins; D014470:Umbilical Cord / Q000033:anatomy & histology / Q000098:blood supply