Partial seizure provoked by hyperbaric oxygen therapy: possible mechanisms and implications.
Hyperbaric oxygen treatment (HBO2) is used commonly for treatment of bone and soft-tissue radiation necrosis. It may be a potential therapy for radiation necrosis seen after brain irradiation. HBO2 risks include generalized tonic-clonic convulsions. We report a patient after resection of anaplastic astrocytoma and 5,580 cGy of total external-beam radiation treatments with brain radiation necrosis who underwent HBO2 therapy and developed a partial seizure during treatment. Mechanisms and implications are discussed.
Doherty
Michael J
MJ
Swedish Epilepsy Center, Virginia Mason Medical Center, Seattle, Washington 98122, USA. michael.doherty@swedish.org
Hampson
Neil B
NB
D001254:Astrocytoma / Q000532:radiotherapy / Q000601:surgery; D001921:Brain / Q000473:pathology* / Q000528:radiation effects; D001932:Brain Neoplasms / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D004828:Epilepsies, Partial / Q000209:etiology*; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000209:etiology / Q000473:pathology / Q000628:therapy; D011832:Radiation Injuries / Q000209:etiology / Q000473:pathology* / Q000628:therapy*; D020266:Radiotherapy, Conformal / Q000009:adverse effects