title: Optical biosensor with dispersion compensation.
abstract: Dispersion limits performance in many optical systems. In surface plasmon resonance (SPR) biosensors, the sensing area is an optical element in which the dispersion depends on the effective refractive index of the biochemical compounds to be measured. We report a method of compensating for wavelength dispersion in SPR biosensors employing two integrated diffractive optical coupling elements in a polymer substrate. The dispersion compensation is achieved over the whole dynamic measurement range and provides a biosensor more robust to wavelength fluctuations than prism-coupler SPR systems. The concept can readily be employed in other types of sensor measuring refractive-index changes.
authors.affiliation: Vir Biosensor, Vir A/S, Kuldyssen 10, DK-2630 Taastrup, Denmark.
authors.forename: W
authors.initials: W
authors.lastname: Zong
authors.forename: C
authors.initials: C
authors.lastname: Thirstrup
authors.forename: M H
authors.initials: MH
authors.lastname: Sørensen
authors.forename: H C
authors.initials: HC
authors.lastname: Pedersen
mesh_terms: D000465:Algorithms; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008027:Light; D055095:Optics and Photonics / Q000295:instrumentation; D012031:Refractometry / Q000295:instrumentation* / Q000379:methods*; D012542:Scattering, Radiation; D020349:Surface Plasmon Resonance / Q000295:instrumentation* / Q000379:methods*