title: [Comparison of value of free-to total prostate specific antigen, prostate specific antigen density and prostate specific antigen density of transition zone for diagnosis of prostate cancer in patients with a PSA level of 4.1-10 ng/ml].
abstract: OBJECTIVE
  We evaluated the utility of free-to total PSA (F/T PSA) ratio, PSA density (PSAD) and PSA density of the transition zone (PSATZ) in diagnosis of prostate cancer with intermediate PSA level (4.1-10 ng/ml).
  
  
  METHODS
  Between January 2000 and December 2003, systematic prostate biopsies were performed on 178 patients with intermediate PSA level. The clinical values of F/T PSA ratio, PSAD and PSATZ for the detection of prostate cancer were compared by using receiver operating characteristic (ROC) curves.
  
  
  RESULTS
  Overall, 57 of the 178 (32%) patients had prostate carcinoma. The ROC curve analysis showed PSAD and PSATZ were superior to F/T PSA ratio in patients with intermediate PSA level. In patients with total prostate volume greater than 30 cm3, the area under the ROC curve for F/T PSA ratio was greater than that for PSAD and PSATZ.
  
  
  CONCLUSIONS
  PSAD and PSATZ were more powerful predictors of prostate cancer than F/T PSA ratio in patients with intermediate PSA level. While F/T PSA ratio was effective for diagnosis of prostate cancer in prostate volume greater than 30 cm3.
authors.affiliation: Department of Urology, Kanagawa Cancer Center.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Fujinami
authors.forename: Takeshi
authors.initials: T
authors.lastname: Miura
authors.forename: Akitoshi
authors.initials: A
authors.lastname: Takizawa
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Osada
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kawakami
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology; D012372:ROC Curve
chemical_list: D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen