No audible wheezing: nuggets and conundrums from mouse asthma models.
Mouse models of T helper type 2 (Th2) cell-biased pulmonary inflammation have elucidated mechanisms of sensitization, cell traffic, and induced airway hyperresponsiveness (AHR). Nonetheless, most mice lack intrinsic AHR, a central property of human asthma, and disparities persist regarding the contributions of eosinophils and mast cells and the sensitivity to induced AHR in the commonly used mouse strains. We suggest that these discordances, reflecting methodological and genetic differences, may be informative for understanding heterogeneity of human asthma.
Boyce
Joshua A
JA
Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. jboyce@rics.bwh.harvard.edu
Austen
K Frank
KF
D000818:Animals; D001249:Asthma / Q000276:immunology / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000276:immunology / Q000503:physiopathology*; D004195:Disease Models, Animal; D004804:Eosinophils / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology; D008407:Mast Cells / Q000276:immunology; D051379:Mice; D008817:Mice, Mutant Strains; D011014:Pneumonia / Q000276:immunology / Q000503:physiopathology*; D019948:Receptors, Interleukin-4 / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
D019948:Receptors, Interleukin-4; D007073:Immunoglobulin E