[Modulation of electrical and contractile responses of the isolated abdominal aorta in hyperholesterinemia and after treatment with calcium antagonists].
Membrane potential of aorta's endothelium, contractile responses of isolated preparation of the abdominal aorta and their modulation with calcium antagonists were studied at hypercholesterinemia (HHS). Membrane potential has been observed to be slightly depolarized at HHS, and acetylcholine-induced electric and contractile responses were shown to be depressed. Calcium antagonists had positive effect on MP, electric and contractile responses of the preparations of the abdominal aorta of rats with HHS. The most pronounced protective effect of membrane potential and contractile responses at HHS was observed in rats after asparcam using.
Liashenko
V P
VP
Dnipropetrovsk National University.
Pasichnichenko
O M
OM
D000818:Animals; D001012:Aorta, Abdominal / Q000187:drug effects / Q000502:physiology*; D002121:Calcium Channel Blockers / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology; D006937:Hypercholesterolemia / Q000188:drug therapy / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D051381:Rats; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*; D014665:Vasodilator Agents / Q000494:pharmacology
D002121:Calcium Channel Blockers; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents