Effect of the interaction between paranoxonase 1 and ATP-binding cassette transporter 1 gene polymorphism on serum lipid level.
OBJECTIVE
To investigate the effect of interaction between paranoxonase 1 (PON1)gene polymorphism and ATP-binding cassette transporter 1 (ABCA1) genetic variation on serum lipid level.


METHODS
Polymerase chain reaction-restricted fragments length polymorphism was used to determine PON1 A/B192 and ABCA1R219K genotype of 1019 subjects, including 680 patients with strokes and 339 healthy individuals as controls.


RESULTS
No significant association between A/B192 genotype and any of the lipid measurements was detected. The levels of HDL-C in the subjects with RR, RK and KK genotypes showed a significant upward tendency respectively (P < 0.05); the levels of their triglyceride (TG) tended downward respectively, but there were no significant differences between them. The relationship between R219K genotype and serum lipid level was modified by A/B192 genotype. The levels of HDL-C in the subjects with AA/RR genotype and BB/KK genotype [(1.41 +/- 0.40) mmol/L, (1.41 +/- 0.39) mmol/L] were significantly different from that in the subjects with BB/RR genotype [(1.28 +/- 0.36) mmol/L] (P < 0.05).


CONCLUSIONS
The result exhibited an interaction of PON1 A/B192 and ABCA1 R219K on serum lipid level.
Xiao
Zhi-jie
ZJ
Department of Neurology, Xiangya Second Hospital, Central South University, Changsha, Hunan, 410011, PR China. xiaozhijie720@sina.com
Zhao
Shui-ping
SP
Nie
Sai
S
Tan
Li-min
LM
Wu
Jun
J
Jiang
Bo
B
Lu
Wei
W
D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000368:Aged; D043303:Aryldialkylphosphatase / Q000235:genetics*; D001483:Base Sequence; D005260:Female; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D017422:Sequence Analysis, DNA
D018528:ATP-Binding Cassette Transporters; D008055:Lipids; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human