New horizons in orthopaedics: a rational discussion of biologics and bone graft substitutes.
Numerous inductive proteins, conductive substrates, and autogenous cellular concentration techniques have become clinically available as substitutes for autogenous bone graft. This review presents a critical analysis of their preclinical and clinical efficacy. In many instances, the widespread use of these materials must be questioned based on the limited clinical data available. A thorough knowledge of these materials is crucial for the surgeon to match the material to its defined indications.
Watson
J Tracy
JT
Department of Orthopaedic Surgery, Division of Orthopaedic Traumatology, Saint Louis University School of Medicine, USA.
D001672:Biocompatible Materials / Q000627:therapeutic use; D001688:Biological Products / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation / Q000379:methods; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods*; D017102:Fracture Healing / Q000187:drug effects*; D006801:Humans; D017713:Platelet Transfusion / Q000379:methods
D001672:Biocompatible Materials; D001688:Biological Products; D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes