title: Hemopressin: a novel bioactive peptide derived from the alpha1-chain of hemoglobin.
abstract: Hemopressin (PVNFKFLSH), a novel bioactive peptide derived from the alpha1-chain of hemoglobin, was originally isolated from rat brain homogenates. Hemopressin causes hypotension in anesthetized rats and is metabolized in vivo and in vitro by endopeptidase 24.15 (EP24.15), neurolysin (EP24.16), and angiotensin-converting enzyme (ACE). Hemopressin also exerts an antinociceptive action in experimental inflammatory hyperalgesia induced by carrageenin or bradykinin via a mechanism that is independent of opioids. These findings suggest that this peptide may have important regulatory physiological actions in vivo.
authors.affiliation: Laboratório de Fisiopatologia, Instituto Butantan, São Paulo, SP 05503-900, Brasil. camisdale@butantan.gov.br
authors.forename: Camila Squarzoni
authors.initials: CS
authors.lastname: Dale
authors.forename: Rosana de Lima
authors.initials: Rde L
authors.lastname: Pagano
authors.forename: Vanessa
authors.initials: V
authors.lastname: Rioli
mesh_terms: D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D006454:Hemoglobins / Q000302:isolation & purification / Q000494:pharmacology*; D006930:Hyperalgesia / Q000188:drug therapy*; D007022:Hypotension / Q000139:chemically induced*; D008297:Male; D010446:Peptide Fragments / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats
chemical_list: D000700:Analgesics; D006454:Hemoglobins; D010446:Peptide Fragments; C473218:hemopressin