Preterm birth and low birth weight after assisted reproductive technology-related pregnancy in Australia between 1996 and 2000.
OBJECTIVE
To describe patterns of preterm birth and low birth weight (LBW) for infants born after assisted reproductive technology (ART) and determine whether these were associated with maternal or treatment characteristics.


METHODS
Retrospective cohort study of national population data of infants conceived through ART.


METHODS
Australian birth records from 1996 to 2000.


METHODS
Eighteen thousand, four hundred twenty-nine liveborn and stillborn infants conceived through ART.


METHODS
In vitro fertilization, intracytoplasmic sperm injection, and gamete intrafallopian transfer.


METHODS
Preterm birth and LBW.


RESULTS
Preterm birth and LBW were more common among singletons and twins conceived with IVF and born to nulliparous mothers. Preterm birth and LBW were, respectively, 1.3 times and 1.5 times more likely to occur among singletons conceived by transfer of fresh embryos, compared with transfer of frozen embryos. Preterm birth and LBW was more common among couples who had female-factor infertility compared with male-factor infertility.


CONCLUSIONS
The transfer of fresh embryos and female-factor infertility were independently associated with preterm birth and LBW for both singletons and twins after ART.
Wang
Yueping Alex
YA
School of Women's and Children's Health, University of New South Wales, Sydney, New South Wales, Australia.
Sullivan
Elizabeth A
EA
Black
Deborah
D
Dean
Jishan
J
Bryant
Joanne
J
Chapman
Michael
M
D000328:Adult; D001315:Australia / Q000453:epidemiology; D004624:Embryo Transfer / Q000706:statistics & numerical data / Q000639:trends; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight / Q000502:physiology; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D047928:Premature Birth / Q000453:epidemiology*; D027724:Reproductive Techniques, Assisted / Q000706:statistics & numerical data / Q000639:trends*; D012189:Retrospective Studies