title: Lp-PLA2 inhibitory activities of fatty acid glycerols isolated from Saururus chinensis roots.
abstract: (R)-Glycerol-monolinoleate 4 and (R)-glycerol-monostearate 5 were isolated from the ethyl acetate extracts of Saururus chinensis roots and (R)- or (S)-fatty acid glycerols 4 and 5 were synthesized for confirming their structures and evaluating their inhibitory activities against Lp-PLA(2). The (R)-4 and (S)-4 exhibited Lp-PLA(2) inhibitory activities with IC(50) values of 45.0 and 52.0 microM, respectively.
authors.affiliation: National Research Laboratory of Lipid Metabolism and Atherosclerosis, Korea Research Institute of Bioscience and Biotechnology, 52 Oun, Yusong, Daejeon 305-333, Republic of Korea.
authors.forename: Woo Song
authors.initials: WS
authors.lastname: Lee
authors.forename: Mi Jeong
authors.initials: MJ
authors.lastname: Kim
authors.forename: Young-Il
authors.initials: YI
authors.lastname: Beck
authors.forename: Yong-Dae
authors.initials: YD
authors.lastname: Park
authors.forename: Tae-Sook
authors.initials: TS
authors.lastname: Jeong
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D005989:Glycerides / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010741:Phospholipases A / Q000037:antagonists & inhibitors / Q000378:metabolism*; D054467:Phospholipases A2; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal; D032134:Saururaceae / Q000737:chemistry*
chemical_list: D005989:Glycerides; C048159:glyceryl monostearate; D010741:Phospholipases A; D054467:Phospholipases A2; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; C048627:monolinolein