Phenytoin may increase the efficacy of temozolomide by methylating DNA-repair enzyme, O6-methylguanine-DNA methyltransferase in patients with glioblastoma.
Altundag
Ozden
O
Altundag
Kadri
K
Boruban
Cem
C
Altundag
Muzaffer B
MB
Turen
Selahattin
S
D004260:DNA Repair; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use; D005909:Glioblastoma / Q000188:drug therapy*; D006801:Humans; D008745:Methylation; D019853:O(6)-Methylguanine-DNA Methyltransferase / Q000378:metabolism*; D010672:Phenytoin / Q000378:metabolism*; D000077204:Temozolomide
D010672:Phenytoin; D003606:Dacarbazine; D019853:O(6)-Methylguanine-DNA Methyltransferase; D000077204:Temozolomide