title: A case of encephalomyelopolyneuropathy in vitamin B12 deficiency.
abstract: A case of a 44-years-old patient with unusual clinical presentation of encephalomyelopolyneuropathy in vitamin B12 deficiency is presented. The disease manifested itself with gastrointestinal bleeding, which necessitated emergency hospitalisation in surgical clinic. Clinical examinations revealed atrophic gastritis, pernicious anemia, neurological and mental complications. The diagnosis was made according to the following criteria: physical examination--smooth tongue, atrophic gastritis, mild hepatosplenomegaly; laboratory findings--pernicious anemia, low vitamin B12 serum levels; neurological examination--syndrome of combined damage of the posterior and lateral columns of the spinal cord; magnetic resonance imaging--typical hyperintense areas on T2-weighted images in the posterior columns in the cervical regions of the spinal cord; transcranial magnetic stimulation--prolonged central motor conduction time of the motor evoked potentials bilaterally; psychological examination--cognitive decline. After treatment with vitamin B12 an improvement of the hematological findings, neurological deficit and cognitive impairments was found.
  
  
  CONCLUSIONS
  Neurological complications could be an early manifestation of vitamin B12 deficiency. In diagnostic aspect similar complaints require examination of the serum levels of vitamin B12. The delay in diagnosis and inadequate therapy bear the risk of incomplete recovery of the neurological deficit. The current problem of "cognitive decline" necessitates routine examination of the serum levels of vitamin Bl2 in all patients with initial cognitive impairments and their prompt and approapriate treatment.
authors.affiliation: Clinic of Neurology, University Hospital St George, Plovdiv, Bulgaria.
authors.forename: Penka A
authors.initials: PA
authors.lastname: Atanassova
authors.forename: Nedka T
authors.initials: NT
authors.lastname: Chalakova
authors.forename: Stefan E
authors.initials: SE
authors.lastname: Goranov
authors.forename: Elena M
authors.initials: EM
authors.lastname: Ilieva
authors.forename: Katjia N
authors.initials: KN
authors.lastname: Sotirova
authors.forename: Radka I
authors.initials: RI
authors.lastname: Massaldjieva
mesh_terms: D000328:Adult; D002493:Central Nervous System Diseases / Q000175:diagnosis / Q000209:etiology* / Q000523:psychology; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D008297:Male; D011115:Polyneuropathies / Q000175:diagnosis / Q000209:etiology* / Q000523:psychology; D014805:Vitamin B 12 / Q000097:blood; D014806:Vitamin B 12 Deficiency / Q000150:complications* / Q000175:diagnosis / Q000523:psychology
chemical_list: D014805:Vitamin B 12