Effects of caffeic acid phenethyl ester on lipopolysaccharide-induced lung injury in rats.
Extracts of propolis, a natural beehive product, have been known for centuries to have a variety of beneficial medical properties, among which their anti-inflammatory effect is a major one. Caffeic acid phenethyl ester (CAPE), an active propolis component, has antimicrobial, anti-inflammatory, antioxidant, carcinostatic and immunomodulatory properties. In this study, we aimed to investigate the efficacy of CAPE in endotoxin-induced lung injury in rats. Lung injury was induced by a footpad injection of lipopolysaccharide (LPS). In the treatment group, 10 micromol kg(-1) CAPE was injected intraperitoneally immediately after LPS injection. At 24 h after LPS and/or CAPE injection, blood and lung tissue specimens were collected. MDA levels and MPO activity in serum and lung tissue, serum total antioxidant levels, lung tissue Na(+)/K(+) ATP-ase activity and histopathological evaluation were determined to assess the efficacy of CAPE treatment. CAPE was found to be efficient in reducing inflammation and lung tissue damage induced by LPS in rats.
Koksel
Oguz
O
Department of Thoracic Surgery, Mersin University School of Medicine, Zeytinabahce Caddesi, Turkey. oguzkoksel@mersin.edu.tr
Ozdulger
Ali
A
Tamer
Lulufer
L
Cinel
Leyla
L
Ercil
Menderes
M
Degirmenci
Ulas
U
Unlu
Serdar
S
Kanik
Arzu
A
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000378:metabolism / Q000627:therapeutic use*; D002109:Caffeic Acids / Q000627:therapeutic use*; D008070:Lipopolysaccharides; D008168:Lung / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009195:Peroxidase / Q000096:biosynthesis; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D000254:Sodium-Potassium-Exchanging ATPase / Q000096:biosynthesis
D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D002109:Caffeic Acids; D008070:Lipopolysaccharides; D008315:Malondialdehyde; D009195:Peroxidase; D000254:Sodium-Potassium-Exchanging ATPase; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol