Treatment of non-albicans Candida vaginitis with amphotericin B vaginal suppositories.
OBJECTIVE
This study was undertaken to investigate whether amphotericin B vaginal suppositories would be effective in the treatment of non- albicans Candida vaginitis in women who failed conventional therapy.


METHODS
Thirty-two patients were identified with non- albicans Candida vaginitis. These patients were treated with conventional antifungal agents. Ten patients had persistence of the non- albicans Candida infection after treatment. Amphotericin B 50-mg vaginal suppositories were given nightly for 14 days to this subgroup of treatment failures.


RESULTS
Of 10 women, 8 (80%) who were treated with amphotericin B vaginally initially showed no further infection. One of the treatment successes had 2 recurrences and responded to a second course of amphotericin B but failed a third course. If this patient is considered a treatment failure, then amphotericin B vaginal suppositories were successful in 70% of patients. The medication was well tolerated and local side effects were minimal.


CONCLUSIONS
Amphotericin B vaginal suppositories are a viable treatment option for refractory vaginitis caused by non- albicans Candida .
Phillips
Albert John
AJ
Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, USA. ajphillips@pol.net
D000282:Administration, Intravaginal; D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D002175:Candida / Q000145:classification; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D016896:Treatment Outcome
D000935:Antifungal Agents; D000666:Amphotericin B