title: Smoking, apolipoprotein E genotype, and early onset of coronary heart disease.
abstract: BACKGROUND
  We examined the association between smoking, apolipoprotein E (ApoE) genotype, and early onset of coronary heart disease (CHD).
  
  
  METHODS
  Smoking behaviour and ApoE genotype of 904 patients with CHD aged 30-70 years were assessed with respect to age at onset of CHD.
  
  
  RESULTS
  The adjusted odds ratio for early onset of CHD (< or =55 years) was 1.86 (95% confidence interval, 1.31-2.62) for smokers compared to non-smokers. The ApoE genotype had no significant influence and there was no significant interaction between ApoE genotype and smoking.
  
  
  CONCLUSIONS
  We found smoking but not ApoE genotype to be an independent risk factor for early onset of CHD.
authors.affiliation: Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany. loew@dzfa.uni-heidelberg.de
authors.forename: Michael
authors.initials: M
authors.lastname: Loew
authors.forename: Michael M
authors.initials: MM
authors.lastname: Hoffmann
authors.forename: Harry
authors.initials: H
authors.lastname: Hahmann
authors.forename: Winfried
authors.initials: W
authors.lastname: März
authors.forename: Dietrich
authors.initials: D
authors.lastname: Rothenbacher
authors.forename: Hermann
authors.initials: H
authors.lastname: Brenner
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics*; D015331:Cohort Studies; D003327:Coronary Disease / Q000209:etiology* / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*
chemical_list: D001057:Apolipoproteins E