Chromatin in need of a fix: phosphorylation of H2AX connects chromatin to DNA repair.
A bevy of recent reports have firmly established a mechanistic link between a histone posttranslational modification associated with DNA double-strand breaks and recruitment of chromatin-modifying activities. These papers show that in addition to providing signals for transcriptional regulation, specific histone "codes" can coordinate and target multiple activities involved in DNA repair.
Thiriet
Christophe
C
Department of Biochemistry and Biophysics, University of Rochester Medical Center, New York 14642, USA.
Hayes
Jeffrey J
JJ
D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D004249:DNA Damage; D004260:DNA Repair; D006657:Histones / Q000235:genetics; D006801:Humans; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D014158:Transcription, Genetic
D002843:Chromatin; D006657:Histones