title: Primordial proteins and HIV-Part II.
abstract: Nanobacteria are suspected to be responsible for a number of diseases, i.e., kidney stones, heart disease, ovarian cancer, peripheral neuropathy, and reduced bone mineral density. Being protected by a mineral shell consisting of apatite, the nanovesicles can enter eukaryotic cells. Depending on the host's stress level, nanobacteria may carry a substantial layer of a protein based slime, instrumental in collecting calcium phosphate from the environment. Calcium phosphate is known to mediate the uptake of nucleic acids by eukaryotic cells. Surprisingly, a pathogenic effect of nanobacteria in HIV can be derived primarily from the trafficking of calcium phosphate in HIV infected cells, performed by primordial proteins. The inescapable conclusion is that nanobacteria could promote genetic diversity in HIV.
authors.affiliation: Central Institute of Biomedical Engineering, University of Ulm, 89081 Ulm, Germany. samoan@gmx.net
authors.forename: Andrei P
authors.initials: AP
authors.lastname: Sommer
mesh_terms: D001426:Bacterial Proteins / Q000502:physiology; D001692:Biological Transport; D002130:Calcium Phosphates; D014644:Genetic Variation; D006678:HIV / Q000235:genetics; D015658:HIV Infections / Q000382:microbiology*; D006801:Humans; D046588:Nanoarchaeota / Q000737:chemistry* / Q000472:pathogenicity
chemical_list: D001426:Bacterial Proteins; D002130:Calcium Phosphates; C020243:calcium phosphate