title: Helicobacter pylori prevalence in diabetic patients and its relationship with dyspepsia and autonomic neuropathy.
abstract: OBJECTIVE
  We evaluated the prevalence of Helicobacter pylori (HP) in Type 2 diabetic patients and its relationship with dyspeptic symptoms and complications of diabetes.
  
  
  METHODS
  Seventy-eight Type 2 diabetic patients (54 females, 24 males, mean age: 51.9 +/- 10.6 yr) and 71 non-diabetic control subjects were involved in the study. Patients were questioned for dyspeptic symptoms. Cardiovascular autonomic neuropathy, nephropathy and retinopathy were investigated in diabetic patients. Upper gastrointestinal tract endoscopy was performed for all patients and gastric biopsies were obtained and searched for HP.
  
  
  RESULTS
  Helicobacter pylori prevalence was significantly higher in diabetic patients than in control subjects (75.6 vs 46%, p < 0.05). No differences were found between women and men with regard to HP infection status in diabetic patients. There was no relation between HP and diabetic complications, nephropathy and retinopathy. Helicobacter pylori prevalence was significantly higher in diabetic patients with cardiovascular autonomic neuropathy than in diabetic patients without cardiovascular autonomic neuropathy (90.6 vs 44.0%, p < 0.02). Forty-seven subjects with diabetes had symptoms of dyspepsia (60.3%) and the prevalence of HP was higher in these patients (p < 0.002).
  
  
  CONCLUSIONS
  There is a high prevalence of HP infection in diabetic patients and it is correlated with dyspeptic symptoms. Diabetic subjects complicated with cardiovascular autonomic neuropathy and dyspepsia are at high risk of HP infection and should be carefully investigated and considered for eradication therapy.
authors.affiliation: Department of Endocrinology and Metabolism, Ankara Training Hospital, Ankara, Turkey. neseersoz@hotmail.com
authors.forename: N E
authors.initials: NE
authors.lastname: Gulcelik
authors.forename: E
authors.initials: E
authors.lastname: Kaya
authors.forename: B
authors.initials: B
authors.lastname: Demirbas
authors.forename: C
authors.initials: C
authors.lastname: Culha
authors.forename: G
authors.initials: G
authors.lastname: Koc
authors.forename: M
authors.initials: M
authors.lastname: Ozkaya
authors.forename: E
authors.initials: E
authors.lastname: Cakal
authors.forename: R
authors.initials: R
authors.lastname: Serter
authors.forename: Y
authors.initials: Y
authors.lastname: Aral
mesh_terms: D001342:Autonomic Nervous System Diseases / Q000453:epidemiology* / Q000209:etiology; D001786:Blood Glucose / Q000378:metabolism; D048909:Diabetes Complications / Q000453:epidemiology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003928:Diabetic Nephropathies / Q000453:epidemiology*; D003930:Diabetic Retinopathy / Q000453:epidemiology; D004415:Dyspepsia / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005773:Gastroscopy; D006442:Glycated Hemoglobin / Q000032:analysis; D016481:Helicobacter Infections / Q000453:epidemiology*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period / Q000502:physiology; D011446:Prospective Studies
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin