Dynamic kinetic resolution of N-Boc-2-lithiopyrrolidine.
Asymmetric substitution of the organolithium derived either from N-Boc-2-tributylstannylpyrrolidine by tin-lithium exchange or from N-Boc-pyrrolidine by deprotonation occurs in the presence of a commercially available chiral diamine ligand with high levels of enantioselectivity by a dynamic kinetic resolution pathway.
Coldham
Iain
I
Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, UKS3 7HF. i.coldham@sheffield.ac.uk
Patel
Jignesh J
JJ
Sanchez-Jimenez
Graciela
G