Calcitonin gene-related peptide during sweating in young healthy women.
Calcitonin gene-related peptide (CGRP) concentrations are increased in postmenopausal women and castrated men with symptomatic flushing. We wanted to determine if a CGRP increase exists in the plasma of healthy fertile-age women during sweating. Plasma concentrations of CGRP were measured by radioimmunoassay at maximal sweating during a sauna session and during bicycle exercise both at maximal and 70% of maximal work capacity in 8 healthy women of fertile age. Plasma concentrations of CGRP were unaffected (>90% statistical power) during both experimental sessions. We suggest that sweating itself does not explain the rise in CGRP concentrations observed in flushing postmenopausal women.
Spetz
Anna-Clara E
AC
Division of Obstetrics and Gynecology, Faculty of Health Sciences, University Hospital, Linkoping, Sweden. Anna-Clara.Spetz@LiO.se
Ellefsen
Katrine
K
Theodorsson
Elvar
E
Lassvik
Claes T
CT
Hammar
Mats L
ML
D000328:Adult; D015415:Biomarkers / Q000097:blood; D001831:Body Temperature; D015740:Calcitonin Gene-Related Peptide / Q000097:blood*; D015444:Exercise; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D010060:Ovulation; D011388:Prolactin / Q000097:blood; D012016:Reference Values; D013546:Sweating / Q000502:physiology
D015415:Biomarkers; D011388:Prolactin; D015740:Calcitonin Gene-Related Peptide; D006854:Hydrocortisone