Pathophysiological roles of ectopic tachygastria induced with antral electrical stimulation.
OBJECTIVE
To investigate the pathophysiological roles of tachygastria using antral electrical stimulation (AES).


METHODS
The study was performed on 13 healthy female hound-type dogs chronically implanted with three pairs of serosal electrodes and a gastric cannula (n = 7). In the first experiment (n = 7), the antral motility was measured for three 30-min periods right after a solid meal. AES was performed during the second 30-min period at a tachygastric frequency. In the second experiment (n = 6), gastric slow waves and animal behavior were monitored in the fasting state at baseline and with various parameters of AES.


RESULTS
(1) AES at tachygastric frequencies (7-14 cpm) significantly reduced the percentage of normal 4- to 6-cpm slow waves and induced tachygastria; (2) AES significantly and substantially inhibited the antral motility in the fed state; (3) AES in the fasting state energy dependently induced symptoms, and the symptom score was linearly correlated with the stimulation frequency, and (4) there was a significant negative correlation between percentage of tachygastria and index of antral motility.


CONCLUSIONS
AES induces tachygastria and inhibits the antral motility. Tachygastria is correlated with antral motility.
Zhu
Hongbing
H
Veterans Administration Research Foundation, Oklahoma City, OK, USA.
Ouyang
Hui
H
Chen
J D Z
JD
D000818:Animals; D004285:Dogs; D004558:Electric Stimulation; D004594:Electrophysiology; D005215:Fasting / Q000502:physiology; D005260:Female; D016065:Myoelectric Complex, Migrating / Q000502:physiology*; D019518:Postprandial Period / Q000502:physiology; D011706:Pyloric Antrum / Q000503:physiopathology*