Neural stem cells in inflammatory CNS diseases: mechanisms and therapy.
Autoimmune inflammatory diseases of the central nervous system (CNS) are highly complex in their interaction of different cell populations. The main therapy focus in the last years has been the inhibition of the immune system. Recent progress has shown that endogenous as well as transplanted neural stem cells might positively influence the outcome of such diseases. In this review, we discuss the current concept of the underlying pathogenesis with a specific focus on local CNS cells and potential treatment options.
Magnus
T
T
Laboratory of Neurosciences, National Institute on Aging, Baltimore, Maryland, 21224, USA. magnust@mail.nih.gov
Rao
M S
MS
D002454:Cell Differentiation / Q000502:physiology; D020278:Demyelinating Autoimmune Diseases, CNS / Q000209:etiology / Q000276:immunology / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D007107:Immune System / Q000187:drug effects; D007155:Immunologic Factors / Q000627:therapeutic use; D008954:Models, Biological; D009186:Myelin Sheath / Q000276:immunology / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology; D009457:Neuroglia / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*
D007155:Immunologic Factors