title: [Classification of Wilson's disease based on neurophysiological parameters].
abstract: In addition to hepatolenticular degeneration in Wilson's disease, sensory and extrapyramidal motoric systems are also disturbed. In this study a classification on the basis of neurophysiological parameters (EAEP, VEP, MSEP, TSEP and MEP) was established according to subclinical disturbances of these pathways in patients with Wilson's disease on long-term treatment. A cluster analysis of latencies of these evoked potentials was performed. The results of cluster analysis revealed three types of electrophysiological profiles: type I with normal latencies and types II and III showing different patterns of prolonged latencies. However, there was no correlation between clinical classification and the results of cluster analysis based on the electrophysiological data. The neurophysiological based classification provides additional information about central manifestations and aids in characterizing the progress of the disease.
authors.affiliation: Klinik und Poliklinik für Neurologie der Universität Leipzig. Wieland.Hermann@medizin.uni-leipzig.de
authors.forename: W
authors.initials: W
authors.lastname: Hermann
authors.forename: P
authors.initials: P
authors.lastname: Günther
authors.forename: A
authors.initials: A
authors.lastname: Wagner
authors.forename: T
authors.initials: T
authors.lastname: Villmann
mesh_terms: D000328:Adult; D000368:Aged; D016000:Cluster Analysis; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004569:Electroencephalography / Q000379:methods*; D005071:Evoked Potentials; D005260:Female; D006527:Hepatolenticular Degeneration / Q000145:classification* / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009482:Neurophysiology / Q000379:methods; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index