A novel, adenylate cyclase, signaling mechanism of relaxin H2 action.
For the first time, the adenylate cyclase signaling mechanism (ACSM) of the action of relaxin H2 was revealed and deciphered in human and rat muscle tissues. The comparative study of signaling blocks forming the ACSM of relaxin and insulin (discovered earlier) showed that the postreceptor signaling chain of relaxin coincides with that of insulin. However, the type of relaxin receptor involved in ACSM remains obscure. Currently, the ACSM of relaxin may be represented as a signaling cascade: receptor --> Gi protein (betagamma-dimer) --> phosphatidylinositol 3-kinase (PI3K) --> protein kinase Czeta (PKCzeta) --> Gs protein --> adenylate cyclase.
Shpakov
Alexander
A
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia. alex_shpakov@list.ru
Pertseva
Marianna
M
Kuznetsova
Ludmila
L
Plesneva
Svetlana
S
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D005260:Female; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D009215:Myometrium / Q000187:drug effects / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism; D051381:Rats; D012065:Relaxin / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects*; D000099221:Protein Kinase C zeta
D000262:Adenylyl Cyclases; D007328:Insulin; D011493:Protein Kinase C; D012065:Relaxin; D000099221:Protein Kinase C zeta