Neural-cardiac coupling in threat-evoked anxiety.
Anxiety is a debilitating symptom of many psychiatric disorders including generalized anxiety disorder, mood disorders, schizophrenia, and autism. Anxiety involves changes in both central and peripheral biology, yet extant functional imaging studies have focused exclusively on the brain. Here we show, using functional brain and cardiac imaging in sequential brain and cardiac magnetic resonance imaging (MRI) sessions in response to cues that predict either threat (a possible shock) or safety (no possibility of shock), that MR signal change in the amygdala and the prefrontal and insula cortices predicts cardiac contractility to the threat of shock. Participants with greater MR signal change in these regions show increased cardiac contractility to the threat versus safety condition, a measure of the sympathetic nervous system contribution to the myocardium. These findings demonstrate robust neural-cardiac coupling during induced anxiety and indicate that individuals with greater activation in brain regions identified with aversive emotion show larger magnitude cardiac contractility increases to threat.
Dalton
Kim M
KM
W. M Keck Laboratory for Functional Brain Imaging and Behavior at the Waisman Center, University of Wisconsin, Madison, 53705, USA. kmdalton@facstaff.wisc.edu
Kalin
Ned H
NH
Grist
Thomas M
TM
Davidson
Richard J
RJ
D000222:Adaptation, Physiological / Q000502:physiology; D000293:Adolescent; D000328:Adult; D000679:Amygdala / Q000502:physiology* / Q000503:physiopathology; D001007:Anxiety / Q000503:physiopathology* / Q000523:psychology; D002540:Cerebral Cortex / Q000502:physiology* / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology; D012016:Reference Values