[Advances on study of organophosphate poisoning prevented by Huperzine A].
Currently, it is a concerned project in medicine to study the effective methods for treatment of organophosphate (OP) poisoning. Huperzine A is a potent, reversible red cells acetylcholinesterases (AChE) inhibitor, which shows high specificity for AChE preserving scavenger capacity of plasma butyrylcholinesterase (BuChE) for OP agents, and cross the blood-brain barrier smoothly preventing the AChE in CNS, so the CNS damages induced by the acute OP poisoning were prevented. These review summarizes the results of experimental in animals, prevention mechanism, and prevention value of HupA against OP poison.
Liu
Li
L
National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Sun
Jin-xiu
JX
D000110:Acetylcholinesterase / Q000097:blood; D000470:Alkaloids; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D006168:Guinea Pigs; D008253:Macaca mulatta; D051379:Mice; D062025:Organophosphate Poisoning; D011041:Poisoning / Q000517:prevention & control; D051381:Rats; D012717:Sesquiterpenes / Q000494:pharmacology*
D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D012717:Sesquiterpenes; C050426:huperzine A; D000110:Acetylcholinesterase