Hyponatremia associated with repeated use of levetiracetam.
Levetiracetam (LEV) is increasingly used as adjunctive anticonvulsant therapy because of apparent low toxicity. Somnolence, asthenia, headache, dizziness, and nervousness are the most frequently reported side effects (1). We describe a patient, predisposed to the development of the syndrome of inappropriate antidiuretic hormone secretion (SIADH), in whom hyponatremia developed after two challenges of LEV.
Nasrallah
Khalil
K
Department of Neurology, Henry Ford Hospital, Detroit, Michigan 48202, USA. khalilnass@hotmail.com
Silver
Brian
B
D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002220:Carbamazepine / Q000009:adverse effects / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000097:blood / Q000139:chemically induced*; D007177:Inappropriate ADH Syndrome / Q000097:blood / Q000139:chemically induced; D000077287:Levetiracetam; D010889:Piracetam / Q000009:adverse effects* / Q000031:analogs & derivatives*; D012964:Sodium / Q000097:blood
D000927:Anticonvulsants; D002220:Carbamazepine; D000077287:Levetiracetam; D012964:Sodium; D010889:Piracetam