Serum paraoxonase (a high-density lipoprotein-associated lipophilic antioxidant) activity and lipid profile in experimental acute pancreatitis.
OBJECTIVE
This study was designed to determine the serum lipid profile and the activity of paraoxonase (PON1, the lipophilic antioxidant component of high-density lipoprotein [HDL]-cholesterol) in acute pancreatitis.


METHODS
Acute pancreatitis was induced by injection of ethyl alcohol into the common biliary duct. Oxidative stress marker (malonyldialdehyde), lipid profile, and PON1 activity were determined in the serum.


RESULTS
In the acute pancreatitis group, whereas the mean levels of total cholesterol, low-density lipoproteins, and malonyldialdehyde were significantly higher (P < 0.001 for each), HDL level and PON1 activity were found to be significantly lower (P < 0.001 for each).


CONCLUSIONS
Our results suggest that an abnormal lipid profile and decreased PON1 activity may have a role in the pathogenesis of acute pancreatitis in which HDL-associated antioxidant defense is impaired.
Unal
Ethem
E
Department of Surgery, Haydarpasa Numune Research and Training Hospital, Haydarpasa, Istanbul, Turkey. ethemunal@hotmail.com
Uzun
Hafize
H
Kusaslan
Ramazan
R
Dogan
Mustafa
M
Genc
Habibe
H
Gunes
Pembegul
P
Titiz
Izzet
I
D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000032:analysis*; D043303:Aryldialkylphosphatase / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D018384:Oxidative Stress; D010195:Pancreatitis / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D008055:Lipids; D043303:Aryldialkylphosphatase