title: Membranous nephropathy associated with familial chronic ulcerative colitis in a 12-year-old girl.
abstract: Glomerulonephritis is a rare complication in patients with inflammatory bowel disease. We report a case of membranous nephropathy (MN) in a 12.6-year-old girl with chronic ulcerative colitis. The girl was referred to the hospital with bloody diarrhea and arthralgia. Routine urinalysis showed 1 g/m(2) protein excretion in 24 h. Serum ANCA titers were positive. The diagnoses were confirmed by coloscopy and kidney biopsy. The patient's mother had also suffered from ulcerative colitis in adolescence. Proteinuria normalized under treatment with prednisone (60 mg/m(2)/day) and azathioprine, which was initiated to treat the colitis. Chronic ulcerative colitis can be associated with glomerulonephritis.
authors.affiliation: Children's Hospital, University of Würzburg, Josef Schneider Str. 2, 97080 Würzburg, Germany.
authors.forename: Regina M
authors.initials: RM
authors.lastname: Ridder
authors.forename: Hans W
authors.initials: HW
authors.lastname: Kreth
authors.forename: Eva
authors.initials: E
authors.lastname: Kiss
authors.forename: Hermann J
authors.initials: HJ
authors.lastname: Gröne
authors.forename: Nader
authors.initials: N
authors.lastname: Gordjani
mesh_terms: D001379:Azathioprine / Q000627:therapeutic use; D002648:Child; D003093:Colitis, Ulcerative / Q000150:complications* / Q000188:drug therapy; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D007166:Immunosuppressive Agents; D001379:Azathioprine; D011241:Prednisone