title: [Therapeutic strategy for morning blood pressure elevation in elderly hypertensives].
abstract: Although the cardiovascular events such as stroke, angina pectoris and myocardial infarction can occur at any time of day, it has been known that the peak incidence of the cardiovascular events increases during the morning period. In elderly hypertensives, a greater morning blood pressure surge is associated with an advanced silent cerebrovascular disease as well as a higher incidence of stroke. Thus, the blood pressure control of the early morning period may become an important therapeutic strategy for preventing the cardiovascular events. In this review, we focused on the recent strategy for morning blood pressure rising in the elderly hypertensives.
authors.affiliation: Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus, School of Medicine.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sakima
authors.forename: Shuichi
authors.initials: S
authors.lastname: Takishita
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage; D000368:Aged; D047228:Angiotensin II Type 1 Receptor Blockers / Q000008:administration & dosage; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm; D002986:Clinical Trials as Topic; D017292:Doxazosin / Q000008:administration & dosage; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D012084:Renin-Angiotensin System / Q000502:physiology; D012307:Risk Factors; D020521:Stroke / Q000209:etiology* / Q000517:prevention & control*; D013564:Sympathetic Nervous System / Q000502:physiology
chemical_list: D000317:Adrenergic alpha-Antagonists; D047228:Angiotensin II Type 1 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors; D017292:Doxazosin