Scrotal Ulcers Arising during Treatment with All-trans Retinoic Acid for Acute Promyelocytic Leukemia.
All-trans retinoic acid (ATRA) is effective in approximately 90% of the cases of acute promyelocytic leukemia (APL) with a low incidence of adverse effects. We report a patient with APL who developed skin ulcers of the scrotum concomitant with high fever during treatment that included ATRA. Severe fever was promptly alleviated with discontinuation of ATRA, while the ulcers improved gradually over 3 months. As the clinical features are similar to those of Sweet's syndrome, we should be aware of the possibility that this rare adverse effect may occur in the treatment with ATRA.
Shimizu
Daisuke
D
Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine, Japan.
Nomura
Kenichi
K
Matsuyama
Ryuzo
R
Matsumoto
Yosuke
Y
Ueda
Kyoji
K
Masuda
Koji
K
Taki
Tomohiko
T
Nishida
Kazuhiro
K
Horiike
Shigeo
S
Kishimoto
Saburo
S
Yanagisawa
Akio
A
Taniwaki
Masafumi
M
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001707:Biopsy, Needle; D001853:Bone Marrow / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D012611:Scrotum; D012883:Skin Ulcer / Q000139:chemically induced* / Q000473:pathology; D014212:Tretinoin / Q000009:adverse effects* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D014212:Tretinoin