An interventional magnetic resonance imaging technique for the molecular characterization of intraprostatic dynamic contrast enhancement.
The biological characterization of an individual patient's tumor by noninvasive imaging will have an important role in cancer care and clinical research if the molecular processes that underlie the image data are known. Spatial heterogeneity in the dynamics of magnetic resonance imaging contrast enhancement (DCE-MRI) is hypothesized to reflect variations in tumor angiogenesis. Here we demonstrate the feasibility of precisely colocalizing DCE-MRI data with the genomic and proteomic profiles of underlying biopsy tissue using a novel MRI-guided biopsy technique in a patients with prostate cancer.
Ménard
Cynthia
C
National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.
Susil
Robert C
RC
Choyke
Peter
P
Coleman
Jonathan
J
Grubb
Robert
R
Gharib
Ahmed
A
Krieger
Axel
A
Guion
Peter
P
Thomasson
David
D
Ullman
Karen
K
Gupta
Sandeep
S
Espina
Virginia
V
Liotta
Lance
L
Petricoin
Emanuel
E
Fitchtinger
Gabor
G
Whitcomb
Louis L
LL
Atalar
Ergin
E
Coleman
C Norman
CN
Camphausen
Kevin
K
D001706:Biopsy; D003287:Contrast Media; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology*; D012334:RNA, Neoplasm / Q000302:isolation & purification
D003287:Contrast Media; D012334:RNA, Neoplasm