title: Voriconazole: review of a broad spectrum triazole antifungal agent.
abstract: Voriconazole is a second-generation triazole antifungal agent, structurally derived from fluconazole with an extended spectrum of activity against a wide variety of yeasts and moulds. Developed for the treatment of life-threatening fungal infections, it appears to be an effective therapy option for invasive aspergillosis, fluconazole-resistant candidiasis and refractory or less-common invasive fungal infections. It is available for both oral and intravenous administration and is characterised by an acceptable safety and tolerability spectrum.
authors.affiliation: Division of Oncology-Hematology, Department of Medicine 2, Humboldt University Berlin, Charité Campus Mitte, Berlin, Germany.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Kofla
authors.forename: Markus
authors.initials: M
authors.lastname: Ruhnke
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy; D002177:Candidiasis / Q000188:drug therapy; D000077336:Caspofungin; D003453:Cryptococcosis / Q000188:drug therapy; D003497:Cyclic N-Oxides / Q000378:metabolism; D004195:Disease Models, Animal; D025141:Drug Resistance, Fungal; D004359:Drug Therapy, Combination; D054714:Echinocandins; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D055666:Lipopeptides; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000188:drug therapy*; D010456:Peptides, Cyclic / Q000627:therapeutic use; D011743:Pyrimidines / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D014230:Triazoles / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D003497:Cyclic N-Oxides; D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; D011743:Pyrimidines; D014230:Triazoles; C479414:UK 121265; D015725:Fluconazole; D000077336:Caspofungin; D065819:Voriconazole