title: Spinal-induced hypotension in elderly patients with hip fracture. A comparison of glucose-free bupivacaine with glucose-free bupivacaine and fentanyl.
abstract: Intraoperative hypotension is a common and potentially deleterious event in elderly patients undergoing spinal anaesthesia for repair of hip fractures. The synergism between intrathecal opioids and local anaesthetics may allow a reduction in the dose of local anaesthetic and cause less sympathetic block and hypotension, while still maintaining adequate anaesthesia. We studied 40 elderly patients having either an insertion of a dynamic hip screw or a hemiarthroplasty and compared 9.0 mg glucose-free bupivacaine with added fentanyl 20 microg (group BF) with 11.0 m glucose-free bupivacaine alone (group B). Hypotension was defined as a fall in systolic blood pressure to less than 75% baseline or less than 90 mmHg. The incidence and frequency of hypotension in group BF were less than in group B. Similarly, falls in systolic, diastolic and mean blood pressures were all less in group BF than in group B. However, there were four failed blocks in group BF and one in group B.
authors.affiliation: Department of Anaesthesia, Royal Perth Hospital, Perth, Western Australia.
authors.forename: J W
authors.initials: JW
authors.lastname: Martyr
authors.forename: K J D
authors.initials: KJ
authors.lastname: Stannard
authors.forename: G
authors.initials: G
authors.lastname: Gillespie
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000775:Anesthesia, Spinal; D000779:Anesthetics, Local / Q000009:adverse effects; D001794:Blood Pressure / Q000187:drug effects; D002045:Bupivacaine / Q000009:adverse effects; D004347:Drug Interactions; D005260:Female; D005283:Fentanyl / Q000009:adverse effects; D005947:Glucose / Q000009:adverse effects*; D006620:Hip Fractures / Q000601:surgery*; D006801:Humans; D007022:Hypotension / Q000139:chemically induced*; D007431:Intraoperative Complications / Q000139:chemically induced*; D008297:Male; D020250:Postoperative Nausea and Vomiting / Q000139:chemically induced
chemical_list: D000779:Anesthetics, Local; D005947:Glucose; D005283:Fentanyl; D002045:Bupivacaine