Enhanced relaxation of nanoparticle-bound supercoiled DNA in X-ray radiation.
A therapeutic methodology was developed based on the large X-ray absorption cross-section of gold nanoparticles at high photon energies (>81 keV). Experimental results showed that the amounts of the relaxed circular supercoiled DNA (scDNA) for gold nanoparticle-bound scDNA were more than doubled compared to that for free scDNA under otherwise identical radiation conditions.
Foley
Erika A
EA
Chemistry Department, University of California, Davis, 95616, USA.
Carter
Joshua D
JD
Shan
Fang
F
Guo
Ting
T
D004278:DNA, Superhelical / Q000737:chemistry*; D053758:Nanoparticles; D014965:X-Rays
D004278:DNA, Superhelical