title: Synthesis and antiplatelet activity of thioaryloxyacids analogues of clofibric acid.
abstract: The thiophene-, benzothiazole- and pyridine-thioaryloxyacids analogues of clofibric acid were synthesized and their antiplatelet activity was screened. Some compounds exhibited antiaggregating properties. The platelet-related haemostasis was measured on a PFA-100 analyzer using bull blood.
authors.affiliation: Dipartimento di Scienze del Farmaco, Università degli Studi G. D'Annunzio, via dei Vestini, 66100 Chieti, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Ammazzalorso
authors.forename: Rosa
authors.initials: R
authors.lastname: Amoroso
authors.forename: Mario
authors.initials: M
authors.lastname: Baraldi
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Bettoni
authors.forename: Daniela
authors.initials: D
authors.lastname: Braghiroli
authors.forename: Barbara
authors.initials: B
authors.lastname: De Filippis
authors.forename: Letizia
authors.initials: L
authors.lastname: Giampietro
authors.forename: Maria L
authors.initials: ML
authors.lastname: Tricca
authors.forename: Francesca
authors.initials: F
authors.lastname: Vezzalini
mesh_terms: D000818:Animals; D002417:Cattle; D002995:Clofibric Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D000960:Hypolipidemic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D013844:Thiazoles / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D000960:Hypolipidemic Agents; D013844:Thiazoles; D002995:Clofibric Acid