Role of galanin and galanin(1-15) on central cardiovascular control.
Galanin and the N-terminal fragment Galanin(1-15) are involved in central cardiovascular regulation. The present paper reviews the recent cardiovascular results obtained by intracisternal injections of Galanin and Galanin(1-15) showing that: (A) the Galanin antagonist M40 blocks the central cardiovascular responses induced by Galanin(1-15) but not those elicited by Galanin; (B) both Galanin and Galanin(1-15) induce the expression of c-Fos in cardiovascular nuclei of the medulla oblongata with different temporal and spatial profiles; (C) the cardiovascular action of Galanin(1-15), but not Galanin, is mediated by peripheral beta-receptor stimulation; (D) and it is demonstrated an antagonistic Galanin/alpha2-adrenoceptors interaction as well as a differential modulation of central cardiovascular responses of Angiotensin II by Galanin or Galanin(1-15). All these data strengthen the involvement of both Galanin molecules as neuromodulators on central cardiovascular regulation.
Díaz-Cabiale
Z
Z
Department of Physiology, Faculty of Medicine, University of Málaga, Campus de Teatinos s/n. 29080, Malaga, Spain.
Parrado
C
C
Vela
C
C
Razani
H
H
Coveñas
R
R
Fuxe
K
K
Narváez
J A
JA
D000818:Animals; D001933:Brain Stem / Q000187:drug effects*; D002319:Cardiovascular System / Q000187:drug effects*; D019004:Galanin / Q000494:pharmacology* / Q000502:physiology; D010446:Peptide Fragments / Q000494:pharmacology* / Q000502:physiology
D010446:Peptide Fragments; C086813:galanin (1-15); D019004:Galanin