Photodynamic activity of dibiotinylated aluminum sulfophthalocyanine in vitro and in vivo.
The photodynamic activity of dibiotinylated aluminum sulfophthalocyanine was studied in vitro and in vivo. Dibiotinylated aluminum sulfophthalocyanine provided enhanced phototoxic action on OAT-75 cell monolayers as compared with the parent drug. Photodynamic therapy of mice with Ehrlich carcinoma using dibiotinylated aluminum sulfophthalocyanine (0.25 mg/kg) resulted in enhanced inhibition of tumor growth, pronounced vascular damage (thrombosis and destruction of vascular walls) and eventual tumor necrosis.
Meerovich
Irina G
IG
Laboratory of Physical Biochemistry, A.N.Bach Institute of Biochemistry of Russian Academy of Sciences, Leninsky prospect, Moscow.
Jerdeva
Victoriav
V
Derkacheva
Valentina M
VM
Meerovich
Gennady A
GA
Lukyanets
Eugeny A
EA
Kogan
Eugenia A
EA
Savitsky
Alexander P
AP
D000535:Aluminum / Q000494:pharmacology* / Q000528:radiation effects*; D000818:Animals; D001710:Biotin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D019921:Biotinylation; D018288:Carcinoma, Small Cell; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D008027:Light; D008175:Lung Neoplasms; D051379:Mice; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000494:pharmacology*
D007211:Indoles; D017319:Photosensitizing Agents; C505721:dibiotinylated aluminum sulfophthalocyanine; D001710:Biotin; D000535:Aluminum