title: Thiourea-based non-nucleoside inhibitors of HIV reverse transcriptase as bifunctional organocatalysts in the asymmetric Strecker synthesis.
abstract: The potential of novel and known pyridyl thiourea derivatives (non-nucleoside inhibitors (NNI) of HIV reverse transcriptase) as bifunctional organic catalysts in the asymmetric Strecker synthesis was investigated. It was shown that incorporation of the imidazolyl moiety in place of a pyridyl group results in a new thiourea derivative that displays a much higher catalytic activity.
authors.affiliation: Institut für Organische und Biomolekulare Chemie der Georg-August-Universität Göttingen, Tammannstrasse 2, 37077 Göttingen, Germany. stsogoe@gwdg.de
authors.forename: Svetlana B
authors.initials: SB
authors.lastname: Tsogoeva
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Hateley
authors.forename: Denis A
authors.initials: DA
authors.lastname: Yalalov
authors.forename: Kathrin
authors.initials: K
authors.lastname: Meindl
authors.forename: Christoph
authors.initials: C
authors.lastname: Weckbecker
authors.forename: Klaus
authors.initials: K
authors.lastname: Huthmacher
mesh_terms: D002384:Catalysis; D018360:Crystallography, X-Ray; D006678:HIV / Q000201:enzymology*; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors*; D008958:Models, Molecular; D015394:Molecular Structure; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D018894:Reverse Transcriptase Inhibitors; D054303:HIV Reverse Transcriptase; D013890:Thiourea