title: FoldIndex: a simple tool to predict whether a given protein sequence is intrinsically unfolded.
abstract: An easy-to-use, versatile and freely available graphic web server, FoldIndex is described: it predicts if a given protein sequence is intrinsically unfolded implementing the algorithm of Uversky and co-workers, which is based on the average residue hydrophobicity and net charge of the sequence. FoldIndex has an error rate comparable to that of more sophisticated fold prediction methods. Sliding windows permit identification of large regions within a protein that possess folding propensities different from those of the whole protein.
authors.affiliation: Biological Services, Weizmann Institute of Science, Rehovot 76100, Israel.
authors.forename: Jaime
authors.initials: J
authors.lastname: Prilusky
authors.forename: Clifford E
authors.initials: CE
authors.lastname: Felder
authors.forename: Tzviya
authors.initials: T
authors.lastname: Zeev-Ben-Mordehai
authors.forename: Edwin H
authors.initials: EH
authors.lastname: Rydberg
authors.forename: Orna
authors.initials: O
authors.lastname: Man
authors.forename: Jacques S
authors.initials: JS
authors.lastname: Beckmann
authors.forename: Israel
authors.initials: I
authors.lastname: Silman
authors.forename: Joel L
authors.initials: JL
authors.lastname: Sussman
mesh_terms: D000465:Algorithms; D003196:Computer Graphics; D003198:Computer Simulation; D004735:Energy Transfer; D020407:Internet; D008956:Models, Chemical; D008958:Models, Molecular; D011487:Protein Conformation; D017510:Protein Folding; D011506:Proteins / Q000032:analysis / Q000737:chemistry*; D016415:Sequence Alignment / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*; D012984:Software; D013329:Structure-Activity Relationship; D014584:User-Computer Interface
chemical_list: D011506:Proteins