title: Compliance with and effectiveness of adaptive servoventilation versus continuous positive airway pressure in the treatment of Cheyne-Stokes respiration in heart failure over a six month period.
abstract: OBJECTIVE
  To compare compliance with and effectiveness of adaptive servoventilation (ASV) versus continuous positive airway pressure (CPAP) in patients with the central sleep apnoea syndrome (CSA) with Cheyne-Stokes respiration (CSR) and with congestive heart failure in terms of the apnoea-hypopnoea index (AHI), quality of life, and left ventricular ejection fraction (LVEF) over six months.
  
  
  METHODS
  25 patients (age 28-80 years, New York Heart Association (NYHA) class II-IV) with stable congestive heart failure and CSA-CSR were randomly assigned to either CPAP or ASV. At inclusion, both groups were comparable for NYHA class, LVEF, medical treatment, body mass index, and CSA-CSR.
  
  
  RESULTS
  Both ASV and CPAP decreased the AHI but, noticeably, only ASV completely corrected CSA-CSR, with AHI below 10/h. At three months, compliance was comparable between ASV and CPAP; however, at six months compliance with CPAP was significantly less than with ASV. At six months, the improvement in quality of life was higher with ASV and only ASV induced a significant increase in LVEF.
  
  
  CONCLUSIONS
  These results suggest that patients with CSA-CSR may receive greater benefit from treatment with ASV than with CPAP.
authors.affiliation: Service de Physiologie-Explorations Fonctionnelles, Hôpital Tenon, AP-HP, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Philippe
authors.forename: M
authors.initials: M
authors.lastname: Stoïca-Herman
authors.forename: X
authors.initials: X
authors.lastname: Drouot
authors.forename: B
authors.initials: B
authors.lastname: Raffestin
authors.forename: P
authors.initials: P
authors.lastname: Escourrou
authors.forename: L
authors.initials: L
authors.lastname: Hittinger
authors.forename: P-L
authors.initials: PL
authors.lastname: Michel
authors.forename: S
authors.initials: S
authors.lastname: Rouault
authors.forename: M-P
authors.initials: MP
authors.lastname: d'Ortho
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002639:Cheyne-Stokes Respiration / Q000150:complications / Q000628:therapy*; D045422:Continuous Positive Airway Pressure / Q000379:methods; D005260:Female; D006333:Heart Failure / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D011788:Quality of Life; D012121:Respiration, Artificial / Q000379:methods*; D016896:Treatment Outcome