title: The role of breast-feeding in the development of allergies and asthma.
abstract: Breast-feeding is the preferred method of infant nutrition for numerous reasons. However, its role in the prevention of allergic disease remains controversial. Reasons for this controversy include methodological differences and flaws in the studies performed to date, the immunologic complexity of breast milk itself and, possibly, genetic differences among patients that would affect whether breast-feeding is protective against the development of allergies or is in fact sensitizing. The preponderance of evidence does suggest, however, that there would be much to lose by not recommending breast-feeding. In general, studies reveal that infants fed formulas of intact cow's milk or soy protein compared with breast milk have a higher incidence of atopic dermatitis and wheezing illnesses in early childhood. Consistent with these findings, exclusive breast-feeding should be encouraged for at least 4 to 6 months in infants at both high and low risk of atopy and irrespective of a history of maternal asthma.
authors.affiliation: Southern California Permanente Medical Group, 7060 Clairemont Mesa Boulevard, San Diego, CA 92111, USA. noah.j.friedman@kp.org
authors.forename: Noah J
authors.initials: NJ
authors.lastname: Friedman
authors.forename: Robert S
authors.initials: RS
authors.lastname: Zeiger
mesh_terms: D000485:Allergens / Q000009:adverse effects / Q000276:immunology; D000818:Animals; D001249:Asthma / Q000209:etiology / Q000235:genetics / Q000517:prevention & control; D001942:Breast Feeding / Q000009:adverse effects; D004032:Diet; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology* / Q000235:genetics / Q000517:prevention & control*; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D007774:Lactation; D015201:Meta-Analysis as Topic; D016269:Milk Hypersensitivity / Q000209:etiology / Q000235:genetics / Q000517:prevention & control; D008894:Milk Proteins / Q000009:adverse effects; D008895:Milk, Human / Q000737:chemistry / Q000276:immunology*; D019936:Probiotics / Q000627:therapeutic use; D012307:Risk Factors; D030262:Soybean Proteins / Q000009:adverse effects
chemical_list: D000485:Allergens; D008894:Milk Proteins; D030262:Soybean Proteins