title: [A study of the properties of compacts from a mixed dry binder on the base of alpha-lactose monohydrate and microcrystalline cellulose].
abstract: The paper studies the tensile strength and disintegration time of compacts from the mixed dry binder MicroceLac 100. Tensile strength and disintegration time of tablets were tested in connection with the following factors: compression force, compression rate, addition of magnesium stearate, addition of ascorbic acid, the model active principle. The compression forces employed were 5, 6, and 7 kN, compression rates, 20 and 40 mm/min, stearate concentration 0, 0.4, and 0.8%, ascorbic acid concentration, 25 and 50%. With increasing addition of the stearate, the strength of compacts from MicroceLacu 100 was decreased for both compression rates, but with a higher rate, in a concentration of 0.4%, the decrease in strength was more marked. Disintegration time was increased with compression force and the addition of the stearate, but in all cases it was very short. Increased addition of ascorbic acid further intensified the decrease in the strength of compacts and decreased the disintegration time and the effect of the stearate on it. Disintegration time of compacts with ascorbic acid in a concentration of 50% did not increase with compression force.
authors.affiliation: Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové, Katedra farmaceutické technologie. muzikova@faf.cuni.cz
authors.forename: J
authors.initials: J
authors.lastname: Muzíková
authors.forename: L
authors.initials: L
authors.lastname: Páleník
mesh_terms: D002482:Cellulose; D019245:Compressive Strength; D007785:Lactose; D010592:Pharmaceutic Aids; D013229:Stearic Acids; D013607:Tablets; D013718:Tensile Strength
chemical_list: D010592:Pharmaceutic Aids; D013229:Stearic Acids; D013607:Tablets; C031183:stearic acid; D002482:Cellulose; D007785:Lactose