Cell transformation by light charged particles: review of available data.
Data reported in the literature on neoplastic transformation induced in cultured cells by light charged particles are compared and analyzed as a function of LET and dose protraction. Light charged particles RBE for transformation is maximum between 75 and 120 keV/microm. The majority of the data suggest that RBE values for survival and transformation are of similar magnitude. Dose protraction effects on transformation induction depend on dose, dose rate and on radiation quality.
Bettega
Daniela
D
Dipartimento di Fisica, Università di Milano and INFN, Via Celoria 16, 20133 Milano, Italy. bettega@mi.infn.it
D000512:Alpha Particles; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000528:radiation effects*; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D018499:Linear Energy Transfer; D051379:Mice; D008809:Mice, Inbred C3H; D011522:Protons; D012062:Relative Biological Effectiveness
D011522:Protons