A naturally occurring mutation near the C terminus of the beta-propeller of alpha(IIb) impair the transport of alpha(IIb)beta3 complexes from the endoplasmic reticulum to the Golgi apparatus.
Fu
B
B
Yuan
X
X
Chen
F
F
Xia
K
K
Fu
G
G
D002675:Child, Preschool; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism*; D006801:Humans; D008297:Male; D009154:Mutation; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000235:genetics* / Q000378:metabolism*; D021381:Protein Transport / Q000235:genetics; D013915:Thrombasthenia / Q000209:etiology / Q000235:genetics
D019039:Platelet Glycoprotein GPIIb-IIIa Complex