title: Isolated lower extremity metastases, 9 years after initial diagnosis of retinoblastoma.
abstract: We report the development of isolated lower extremity metastases, in a child, 9 years after her initial diagnosis and treatment of bilateral infantile retinoblastomas. The radiographic, scintigraphic, computed tomographic, and magnetic resonance imaging findings are discussed. The dominant metastatic focus was blastic, involving the medial cuneiform. Additional occult lesions were found in the base of the second metatarsal, middle cuneiform, navicular and tibial diaphysis. An open biopsy confirmed the diagnosis. The occurrence of late distant metastases is rare in the USA.
authors.affiliation: Department of Radiology, Medical School, University of Maryland, 22 South Greene Street, Baltimore, MD 21201, USA. mmulligan@umm.edu
authors.forename: M E
authors.initials: ME
authors.lastname: Mulligan
authors.forename: S E
authors.initials: SE
authors.lastname: Smith
authors.forename: E F
authors.initials: EF
authors.lastname: McCarthy
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000556:secondary*; D002648:Child; D003952:Diagnostic Imaging; D005260:Female; D006801:Humans; D035002:Lower Extremity; D019572:Retinal Neoplasms / Q000473:pathology*; D012175:Retinoblastoma / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents