title: [Differential pressure as an independent factor of cardiovascular risk].
abstract: OBJECTIVE
  To confirm that high differential pressure (DP) supposes greater risk of ischaemic cardiopathy and to assess whether it is also an independent risk factor of suffering a cerebrovascular accident.
  
  
  METHODS
  An analytical, observational, retrospective and longitudinal study with historic cohorts.
  
  
  METHODS
  Urban population of about 18 000 inhabitants.
  
  
  METHODS
  300 patients aged between 15 and 75 with hypertension of > or =2 years evolution, who have had their blood pressure taken by nurses 4 or more times (excluding casualty) and have not suffered a cardiovascular event (CVE), whether coronary accident, cerebrovascular accident or peripheral vasculopathy.
  
  
  METHODS
  The history relating to cardiovascular risk was recorded: lipaemia, obesity, tobacco dependency, diabetes mellitus, left ventricular hypertrophy (LVH). These factors were considered present if their diagnosis preceded the CVE diagnosis. They were placed in 2 groups, depending on the degree of differential pressure: "high" if >60 mm Hg and "not high" if (3/4)60 mm Hg. They were analysed for intention to treat over 10 years, with the appearance or not of a CVE as a response variable.
  
  
  RESULTS
  300 participants (73.3% women), 150 exposed to risk and 150 not exposed. The initial analysis showed significant differences between the 2 groups for age (P<.0001), diabetes (P<.0001), and LVH (P<.001). After logistic regression, the OR of suffering LVH was 2.38 (95% CI, 1.19-4.74) in the group with high DP; the OR of ischaemic cardiopathy, 2.84 (95% CI, 1.16-6.96); and of cerebrovascular accident, 2.70 (95% CI, 1.09-6.68). There were no significant differences for peripheral arteriopathy.
  
  
  CONCLUSIONS
  DP was confirmed as an independent factor of cardiovascular risk and, despite the limitations of the study, it was pointed to as a possible independent factor of cerebrovascular risk.
authors.affiliation: Médico de familia. CAP. La Pau Barcelona, Barcelona, Spain. jignacio@aoiz.net
authors.forename: J I
authors.initials: JI
authors.lastname: Aoiz Linares
authors.forename: J M
authors.initials: JM
authors.lastname: Bonet Simó
authors.forename: F
authors.initials: F
authors.lastname: Solé Sancho
authors.forename: S
authors.initials: S
authors.lastname: Rodríguez Martínez
authors.forename: M C
authors.initials: MC
authors.lastname: Yuste Marco
authors.forename: M
authors.initials: M
authors.lastname: Montasell Pérez
mesh_terms: D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors