[Correlation between expression of matrix metalloproteinase-2 and angiogenesis in esophageal carcinoma].
OBJECTIVE
To study expression of MMP-2 in relation to microvessel density (MVD) in esophageal carcinoma.


METHODS
Forty-eight specimens of esophageal carcinoma (Ec) and 17 specimens of grade II + III epithelial dysplasia (Dy) close to the tumor and 12 specimens of normal tissue (Nt) along the incisional margin were examined by S-P immunohistochemical staining with anti-MMP-2 monoclonal antibody. An anti-CD34 monoclonal antibody was used to show MVD.


RESULTS
MMP-2 expression in Ec was remarkably higher than that in Dy, which was higher than that in Nt. MMP-2 expression in Ec and Dy was significantly correlated with MVD in the tumor and nearby tissue. MMP-2 expression and MVD in Ec significantly associated with lymph node metastasis.


CONCLUSIONS
Expression of MMP-2 plays an important role in angiogenesis and lymph node metastasis of esophageal cancer.
Li
Jie-ru
JR
Department of Pathology, Heibei Medical Collage, Shijiazhuang 050017, China.
Qi
Feng-ying
FY
Li
Li
L
D002294:Carcinoma, Squamous Cell / Q000098:blood supply / Q000201:enzymology* / Q000556:secondary; D004938:Esophageal Neoplasms / Q000098:blood supply / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D008833:Microcirculation / Q000201:enzymology / Q000473:pathology; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000201:enzymology / Q000473:pathology*
D020778:Matrix Metalloproteinase 2