title: Toxicokinetics and biotransformation of p-nitrophenol in white sturgeon (Acipenser transmontanus).
abstract: White sturgeon (Acipencer transmontanus) were exposed to 7.2 microM (1.0 ppm) 14C-labeled p-nitrophenol (PNP) in brackish water for 24 h and then allowed to depurate in clean brackish water for another 24h. Absorption, conditional uptake clearance, and conditional elimination rate constants were 0.08+/-0.04 h(-1), 8.1+/-3.6 mL g(-1) h(-1), and 0.46+/-0.21 h(-1), respectively. A whole-organism total concentration factor of 18.7+/-2.6 was determined from equilibrium tissue and water concentrations. Sturgeon depurated 89.4% of absorbed PNP within 24h, of which 53.0+/-8.3% was unmetabolized parent compound, 9.6+/-3.6% was p-nitrophenyl-beta-d-glucuronide, and 39.1+/-8.3% was p-nitrophenylsulfate.
authors.affiliation: Department of Environmental Toxicology, College of Agricultural and Environmental Sciences, University of California, Davis, CA 95616, USA. ptenbroo@pacbell.net
authors.forename: P L
authors.initials: PL
authors.lastname: TenBrook
authors.forename: S M
authors.initials: SM
authors.lastname: Kendall
authors.forename: R S
authors.initials: RS
authors.lastname: Tjeerdema
mesh_terms: D000818:Animals; D001711:Biotransformation; D005399:Fishes / Q000378:metabolism*; D009043:Motor Activity / Q000187:drug effects; D009596:Nitrophenols / Q000032:analysis / Q000493:pharmacokinetics* / Q000633:toxicity*; D018675:Toxicity Tests; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000493:pharmacokinetics* / Q000633:toxicity*
chemical_list: D009596:Nitrophenols; D014874:Water Pollutants, Chemical; C024836:4-nitrophenol