Effect of oleanane triterpenoids from Terminalia arjuna--a cardioprotective drug on the process of respiratory oxyburst.
The oleanane triterpenes arjunic acid, arjungenin and their glucosides, arjunetin and arjunglucoside II, were isolated from the bark of Terminalia arjuna. Arjungenin and its glucoside exhibited a moderate free radical scavenging activity while all the compounds showed no effect on the superoxide release from PMN cells. Further arjungenin also exhibited greater inhibitory action on the hypochlorous acid production from human neutrophils.
Pawar
R S
RS
Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sect. 67, S.A.S. Nagar, Phase X, (Mohali), Punjab, India.
Bhutani
K K
KK
D001713:Biphenyl Compounds; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D009504:Neutrophils / Q000187:drug effects*; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D029766:Terminalia; D014315:Triterpenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
D001713:Biphenyl Compounds; D002316:Cardiotonic Agents; D016166:Free Radical Scavengers; D010851:Picrates; D010936:Plant Extracts; D014315:Triterpenes; C441431:arjunic acid; C004931:1,1-diphenyl-2-picrylhydrazyl