Micelle-like nanoparticles of PLA-PEG-PLA triblock copolymer as chemotherapeutic carrier.
Triblock copolymer PLA-PEG-PLA were synthesized using ring opening polymerization with different LA/EG ratio. Micellar aggregates were prepared from these block copolymers and characterized. The degradation characteristics of selected copolymers were assessed in both micellar and film forms. Surface segregation of PEG was also quantified as a function of copolymer composition. Anti-cancer drugs 5-FU and paclitaxel were loaded into the micellar nanospheres with good efficiency. The drug release profile showed good control over the release of paclitaxel from these polymers.
Venkatraman
Subbu S
SS
School of Materials Science and Engineering, N4.1-1-30 Nanyang Avenue, Nanyang Technological University, Singapore 639798, Singapore.
Jie
Pan
P
Min
Feng
F
Freddy
Boey Yin Chiang
BY
Leong-Huat
Gan
G
D004337:Drug Carriers; D004355:Drug Stability; D007773:Lactates / Q000008:administration & dosage* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D049329:Nanostructures; D017239:Paclitaxel / Q000008:administration & dosage* / Q000737:chemistry; D010316:Particle Size; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility; D013499:Surface Properties
D004337:Drug Carriers; D007773:Lactates; D008823:Micelles; C088513:poly(lactic acid-ethylene glycol); D011092:Polyethylene Glycols; D017239:Paclitaxel