title: Immortalized human microglial cell line: phenotypic expression.
abstract: Microglia are a major neuroglial component of the CNS, playing an important role as resident immunocompetent and phagocytic cells in the CNS in the event of injury and disease. To understand the role of microglia in the CNS in health and diseases, we have recently established an immortalized clonal cell line of human microglia, HMO6, from human embryonic telencephalon tissue by using a retroviral vector encoding v-myc. This immortalized microglia HMO6 cell line exhibits cell-type-specific antigens for microglia, including CD11b (Mac-1), CD68, CD86 (B7-2), HLA-ABC, HLA-DR, and RCA-1 lectin, and actively phagocytoses latex beads.
authors.affiliation: Department of Neurology, Shimane University School of Medicine, Izumo, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nagai
authors.forename: Seiji
authors.initials: S
authors.lastname: Mishima
authors.forename: Yuri
authors.initials: Y
authors.lastname: Ishida
authors.forename: Hiroto
authors.initials: H
authors.lastname: Ishikura
authors.forename: Takayuki
authors.initials: T
authors.lastname: Harada
authors.forename: Shotai
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Seung U
authors.initials: SU
authors.lastname: Kim
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000378:metabolism; D002460:Cell Line; D017690:Cell Transplantation; D018925:Chemokines / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D051379:Mice; D017628:Microglia / Q000166:cytology* / Q000502:physiology; D010641:Phenotype
chemical_list: D018925:Chemokines; D016207:Cytokines