title: Altitude decompression sickness susceptibility: influence of anthropometric and physiologic variables.
abstract: BACKGROUND
  There is considerable variability in individual susceptibility to altitude decompression sickness (DCS). The Air Force Research Laboratory Altitude DCS Research Database consists of extensive information on 2980 altitude exposures conducted with consistent procedures and endpoint criteria. We used this database to quantify the variation in susceptibility and determine if anthropometric and/or physiologic variables could be used to predict DCS risk.
  
  
  METHODS
  There were 240 subjects who participated in at least 4 of 70 exposure profiles in which between 5 and 95% of all subjects tested developed DCS symptoms. A subject/study ratio (SSR) was calculated by dividing the DCS experienced by a subject during all their exposures by the DCS incidence for all subjects who participated in the identical exposures. The SSR was used to identify the relative susceptibility of subjects for use in analyzing possible relationships between DCS susceptibility and the variables of height, weight, body mass index, age, percent body fat, and aerobic capacity.
  
  
  RESULTS
  The DCS incidence was 46.5% during 1879 subject-exposures by subjects exposed at least 4 times. A significant relationship existed between higher DCS susceptibility and the combination of lower aerobic capacity and greater weight (p < 0.05).
  
  
  CONCLUSIONS
  Despite a correlation, less than 13% of the variation in DCS susceptibility was accounted for by the best combination of variables, weight and VO2max.
  
  
  CONCLUSIONS
  Differences in DCS susceptibility cover a wide range and appear to be related to some anthropometric and physiologic variables. However, there was insufficient correlation to allow prediction of an individual's susceptibility.
authors.affiliation: Biosciences and Protection Division, Air Force Research Laboratory, Brooks City-Base, TX, USA. james.webb.ctr@brooks.af.mil
authors.forename: James T
authors.initials: JT
authors.lastname: Webb
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Pilmanis
authors.forename: Ulf I
authors.initials: UI
authors.lastname: Balldin
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Fischer
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D000337:Aerospace Medicine; D000531:Altitude; D000886:Anthropometry; D015992:Body Mass Index; D019992:Databases as Topic; D003665:Decompression Sickness / Q000209:etiology*; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008297:Male; D008887:Military Medicine; D012307:Risk Factors