Cystic lesion of the parotid following drug-induced toxic epidermal necrolysis (Lyell's syndrome).
A 32-year-old woman developed a unilateral cyst of the duct of parotid gland 4 months after severe oral involvement of drug-induced toxic epidermal necrolysis (TEN). The pathomechanism leading to the TEN epidermal destruction had presumably involved the salivary epithelium as well, leading to the development of the cystic lesion. The patient had low serum lipase levels, but high serum amylase levels at the time of TEN. These serological markers could represent a clue for the risk of developing cystic lesions of the large salivary glands following TEN.
Paquet
P
P
Department of Dermatopathology University Hospital Sart Tilman, Liège, Belgium. P.Paquet@chu.ulg.ac.be
Jacob
E
E
Piérard
G E
GE
D000328:Adult; D000681:Amylases / Q000097:blood; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D003560:Cysts / Q000209:etiology* / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects; D008049:Lipase / Q000097:blood; D010305:Parotid Diseases / Q000209:etiology* / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000201:enzymology / Q000209:etiology*
D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D008049:Lipase; D000681:Amylases; D007052:Ibuprofen