title: Controversies in off-pump coronary artery surgery.
abstract: Motivated by a desire to reduce the morbidity of a well-established and effective procedure for coronary artery disease, up to 25% of coronary artery bypass operations are being performed without the use of a heart-lung pump. Concerns remain about the quality of the coronary anastomoses and the completeness of revascularization. Randomized trials have not revealed the significant reduction in morbidity or mortality that the early enthusiasts had hoped for. Yet a number of non-randomized studies have shown clinical benefit from the avoidance of an extracorporeal circulation, but these have been criticized for potential bias in patient selection and management.A majority of surgeons have not yet adopted this technique and are waiting for the accumulation of more evidence.
authors.affiliation: Department of Surgery, Royal Brompton Hospital, Sydney Street, London SW3 6NP, United Kingdom. J.Pepper@rbh.nthames.nhs.uk
authors.forename: John
authors.initials: J
authors.lastname: Pepper
mesh_terms: D000367:Age Factors; D002986:Clinical Trials as Topic; D001026:Coronary Artery Bypass / Q000379:methods; D047549:Coronary Artery Bypass, Off-Pump / Q000379:methods*; D003324:Coronary Artery Disease / Q000401:mortality / Q000601:surgery; D003331:Coronary Vessels / Q000601:surgery*; D006801:Humans; D018919:Neovascularization, Physiologic; D011788:Quality of Life; D011897:Random Allocation; D012306:Risk; D012307:Risk Factors; D012923:Social Class; D016896:Treatment Outcome