title: [Observation on clinical efficacy of combined therapy of zinc supplement and jinye baidu granule in treating human cytomegalovirus infection].
abstract: OBJECTIVE
  To explore the clinical efficacy of the combined therapy of zinc supplement and Jinye Baidu granule (JBG) on human cytomegalovirus (HCMV) infection.
  
  
  METHODS
  One hundred and forty patients with positive HCMV-IgM were randomly divided into four groups, with 35 cases in each group, that is, the control group (only medicated with JBG), the high-, moderate- and low-dose zinc combined groups (treated with JBG combined with zinc gluconate tablet at dose of 30 mg, 20 mg, 10 mg every day respectively). The negative conversion rate of HCMV-IgM was observed.
  
  
  RESULTS
  Insignificant difference in the negative conversion rate was shown in comparison of the control group with the low dose group (P > 0.05), and in comparison of the high dose with the moderate dose group (P > 0.05); however, the rate was significantly lower in the control group than that in the moderate dose and high dose group (P < 0.05).
  
  
  CONCLUSIONS
  Combined therapy of zinc supplement and JBG can significantly increase the negative conversion rate of HCMV-IgM. The optimal dosage of zinc gluconate tablet was 20 mg once a day.
authors.affiliation: Department of Obstetrics and Gynecology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan.
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.forename: Liang-zhen
authors.initials: LZ
authors.lastname: Wen
authors.forename: Hui
authors.initials: H
authors.lastname: Y uan
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D000998:Antiviral Agents / Q000627:therapeutic use; D003587:Cytomegalovirus / Q000187:drug effects*; D003586:Cytomegalovirus Infections / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008517:Phytotherapy; D015032:Zinc / Q000627:therapeutic use*
chemical_list: D000914:Antibodies, Viral; D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D007075:Immunoglobulin M; D015032:Zinc