title: Outcomes and pathological review of a cohort of children with melanoma.
abstract: BACKGROUND
  Prepubertal malignant melanoma is rare, pathological criteria are difficult and follow-up data on patients are lacking in the literature.
  
  
  OBJECTIVE
  To review prepubertal cases of melanoma diagnosed in the West of Scotland 1979-2002.
  
  
  METHODS
  Twenty cases were identified in whom melanoma was diagnosed before the age of 15. Pathological review was possible for 13 of 20 cases, and current follow-up information is available for all 20. Three pathologists not responsible for the original diagnosis reviewed the slides independently, in every case without knowledge of the outcome.
  
  
  RESULTS
  Of the 13 cases reviewed, there was concordance of diagnosis between the three pathologists in 12 cases. Eight of the 13 cases reviewed were considered to be unusual naevi rather than melanoma. One child has died of melanoma and all three pathologists agreed with the original pathological diagnosis. One patient has experienced nodal metastases but is alive and disease-free 12 years later. The remaining 18 cases have had no recurrence since primary surgery 2-21 years ago.
  
  
  CONCLUSIONS
  There may be a tendency to overdiagnose prepubertal melanoma. Good communication between clinician and pathologist and the use of an expert pathology panel is recommended before making the diagnosis.
authors.affiliation: Department of Dermatology, Stirling Royal Infirmary, Stirling FK8 2AU, UK. joyce.leman@fvah.scot.nhs.uk
authors.forename: J A
authors.initials: JA
authors.lastname: Leman
authors.forename: A
authors.initials: A
authors.lastname: Evans
authors.forename: W
authors.initials: W
authors.lastname: Mooi
authors.forename: R M
authors.initials: RM
authors.lastname: MacKie
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000473:pathology* / Q000601:surgery; D009506:Nevus / Q000473:pathology; D012606:Scotland; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery