Mitochondrial DNA, aconitase 'wraps' it up.
Mitochondria are the sites of many essential biochemical reactions, an important subset of which require proteins encoded in the mitochondrial DNA (mtDNA). How mtDNA is regulated in response to changing cellular demands is largely unknown. A recent study documents that the mitochondrial TCA-cycle enzyme aconitase is associated with protein-mtDNA complexes called nucleoids. In this novel context, aconitase functions to stabilize mtDNA, perhaps by reversibly remodeling nucleoids to directly influence mitochondrial gene expression in response to changing cellular metabolism.
Shadel
Gerald S
GS
Department of Pathology, Yale University School of Medicine, P.O. Box 208023, New Haven, CT 06520-8023, USA. gerald.shadel@yale.edu
D000154:Aconitate Hydratase / Q000378:metabolism*; D002952:Citric Acid Cycle / Q000502:physiology; D004272:DNA, Mitochondrial / Q000737:chemistry / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D004798:Enzymes / Q000378:metabolism; D018384:Oxidative Stress; D040901:Proteomics / Q000379:methods; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
C072843:ABF2 protein, S cerevisiae; D004272:DNA, Mitochondrial; D004268:DNA-Binding Proteins; D004798:Enzymes; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D000154:Aconitate Hydratase