ADAM9, ADAM10, and ADAM15 mRNA levels in the rat brain after kainic acid-induced status epilepticus.
ADAM metalloprotease-disintegrins mediate cell adhesion, proteolytic processing, and signal transduction. In the present study, the mRNA levels of ADAM9, ADAM10, and ADAM15 were examined in rat brain after kainic acid (KA)-induced status epilepticus. ADAM9 and ADAM10 expression was induced in dentate gyrus of hippocampus. ADAM15 expression remained unchanged. The spatiotemporal expression of ADAM9 and ADAM10 suggests that their regulation after the KA-induced status epilepticus could be related to neuroprotection.
Ortiz
R M
RM
Cell Signaling Laboratory, Institute of Medical Technology, FIN-33014, University of Tampere and Tampere University Hospital, Finland. rebekka.ortiz@uta.fi
Kärkkäinen
I
I
Huovila
A-P J
AP
Honkaniemi
J
J
D051722:ADAM Proteins; D053829:Amyloid Precursor Protein Secretases; D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000235:genetics*; D003292:Convulsants; D018891:Dentate Gyrus / Q000378:metabolism* / Q000503:physiopathology; D004195:Disease Models, Animal; D019483:Disintegrins / Q000235:genetics*; D010450:Endopeptidases; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D007608:Kainic Acid; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008666:Metalloendopeptidases / Q000235:genetics*; D045726:Metalloproteases / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013226:Status Epilepticus / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D015854:Up-Regulation / Q000187:drug effects / Q000502:physiology
D003292:Convulsants; D019483:Disintegrins; D018690:Excitatory Amino Acid Agonists; D008565:Membrane Proteins; D012333:RNA, Messenger; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D045726:Metalloproteases; D016282:Aspartic Acid Endopeptidases; D051722:ADAM Proteins; C490901:Adam15 protein, rat; C503705:Adam9 protein, rat; D008666:Metalloendopeptidases; D007608:Kainic Acid