Dapsone syndrome with acute renal failure during leprosy treatment: case report.
Dapsone syndrome is a rare hypersensitivity reaction to dapsone and is characterized by high fever, papular or exfoliative dermatitis, progressing to liver toxicity and generalized lymphadenopathy, resembling a mononucleosis infection. We report a patient who developed acute renal failure, as well as other complications characteristic of dapsone syndrome, during leprosy treatment. Renal involvement had not been previously described as a dapsone syndrome feature.
Alves-Rodrigues
Edson Nogueira
EN
Medical Clinics Department, Centre of Infectious Diseases and Tropical Diseases Research of Mato Grosso, Júlio Müller Hospital, Cuiabá, MT, Brazil.
Ribeiro
Luciano Correa
LC
Silva
Margareth Dióz
MD
Takiuchi
Arley
A
Fontes
Cor Jesus Fernandes
CJ
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D002991:Clofazimine / Q000008:administration & dosage; D003622:Dapsone / Q000008:administration & dosage / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000150:complications*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007917:Leprostatic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D007918:Leprosy / Q000188:drug therapy*; D012293:Rifampin / Q000008:administration & dosage; D013577:Syndrome
D007917:Leprostatic Agents; D003622:Dapsone; D002991:Clofazimine; D012293:Rifampin