Ovarian transplantation between monozygotic twins discordant for premature ovarian failure.
Monozygotic 24-year-old twins presented with discordant ovarian function. One had had premature ovarian failure at the age of 14 years, whereas her sister had normal ovaries and three naturally conceived children. After unsuccessful egg-donation therapy, the sterile twin received a transplant of ovarian cortical tissue from her sister by means of a minilaparotomy. Within three months after transplantation, the recipient's cycles resumed and serum gonadotropin levels fell to the normal range. During the second cycle, she conceived, and her pregnancy progressed uneventfully. At 38 weeks' gestation, she delivered a healthy-appearing female infant.
Silber
Sherman J
SJ
Infertility Center of St. Louis, St. Luke's Hospital, St. Louis, MO 63017, USA. drsherm@aol.com
Lenahan
Kathleen M
KM
Levine
David J
DJ
Pineda
Jorge A
JA
Gorman
Kim S
KS
Friez
Michael J
MJ
Crawford
Eric C
EC
Gosden
Roger G
RG
D000328:Adult; D004200:Diseases in Twins / Q000601:surgery*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007247:Infertility, Female / Q000209:etiology / Q000601:surgery*; D010053:Ovary / Q000002:abnormalities / Q000166:cytology / Q000637:transplantation*; D011247:Pregnancy; D016649:Primary Ovarian Insufficiency / Q000150:complications / Q000601:surgery*; D014430:Twins, Monozygotic