title: An entry to a chiral dihydropyrazole scaffold: enantioselective [3 + 2] cycloaddition of nitrile imines.
abstract: We have developed a versatile strategy to access dihydropyrazoles in highly enantioenriched form. Dipolar cycloaddition of electron-deficient acceptors and in situ-generated nitrile imines proceeds with high regio- and enantioselectivity using 10 mol % chiral Lewis acid catalyst. A variety of dihydropyrazoles that incorporate functionality for further manipulation have been prepared.
authors.affiliation: Department of Chemistry, North Dakota State University, Fargo, ND 58105, USA.
authors.forename: Mukund P
authors.initials: MP
authors.lastname: Sibi
authors.forename: Levi M
authors.initials: LM
authors.lastname: Stanley
authors.forename: Craig P
authors.initials: CP
authors.lastname: Jasperse