Recombination at collapsed replication forks: the payoff for survival.
Recombination is believed to assist replication when forks collapse. By using an elegant system, Lambert et al. (2005) address the consequences of recombination at blocked forks. They show that chromosomal rearrangements are the price to pay for cell viability when forks collapse.
Pellicioli
Achille
A
Istituto FIRC di Oncologia Molecolare, Milano, Italy.
Foiani
Marco
M
D004261:DNA Replication; D004277:DNA, Single-Stranded; D004926:Escherichia coli; D015321:Gene Rearrangement; D011995:Recombination, Genetic; D012568:Schizosaccharomyces
D004277:DNA, Single-Stranded