title: Expression of BLT1 leukotriene B4 receptor on the dorsal root ganglion neurons in mice.
abstract: We investigated using mice whether dorsal root ganglion (DRG) neurons express leukotriene B4 receptors. BLT1, but not BLT2, receptor mRNA was expressed in the DRG. Leukotriene B4 increased intracellular Ca2+ concentration in cultured DRG neurons, which was inhibited by leukotriene B4 antagonist. Many BLT1-immunoreactive neurons were small in size and positive for TRPV1. BLT1-immunoreactive fibers are present in the skin. The results suggest the expression of functional BLT1 receptors in the sensory neurons.
authors.affiliation: Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Tsugunobu
authors.initials: T
authors.lastname: Andoh
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kuraishi
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling / Q000502:physiology; D048429:Cell Size; D002478:Cells, Cultured; D005727:Ganglia, Spinal / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D007424:Intracellular Fluid / Q000378:metabolism; D007473:Ion Channels / Q000378:metabolism; D007975:Leukotriene B4 / Q000378:metabolism* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009475:Neurons, Afferent / Q000187:drug effects / Q000378:metabolism*; D012333:RNA, Messenger / Q000187:drug effects / Q000378:metabolism; D018102:Receptors, Leukotriene B4 / Q000235:genetics* / Q000378:metabolism*; D011984:Sensory Receptor Cells / Q000378:metabolism; D012867:Skin / Q000294:innervation; D050916:TRPV Cation Channels
chemical_list: D007473:Ion Channels; C503704:Ltb4r1 protein, mouse; D012333:RNA, Messenger; D018102:Receptors, Leukotriene B4; D050916:TRPV Cation Channels; C493921:TRPV1 protein, mouse; D007975:Leukotriene B4; D002118:Calcium