title: Versatile use of ytterbium(III) triflate and acid washed molecular sieves in the activation of glycosyl trifluoroacetimidate donors. Assemblage of a biologically relevant tetrasaccharide sequence of Globo H.
abstract: The nonreducing tetrasaccharide terminus of Globo H has been assembled in good yield and excellent stereocontrol exclusively by using mild and moisture stable agents such as Yb(OTf)(3) and acid washed molecular sieves for the activation of glycosyltrifluoroacetimidate donors in the glycosylation steps.
authors.affiliation: Dipartimento di Chimica Organica e Biochimica, Via Cynthia 4, I-80126 Naples, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Adinolfi
authors.forename: Alfonso
authors.initials: A
authors.lastname: Iadonisi
authors.forename: Alessandra
authors.initials: A
authors.lastname: Ravidà
authors.forename: Marialuisa
authors.initials: M
authors.lastname: Schiattarella
mesh_terms: D015295:Antigens, Tumor-Associated, Carbohydrate / Q000737:chemistry*; D002240:Carbohydrate Sequence; D002384:Catalysis; D006031:Glycosylation; D009844:Oligosaccharides / Q000737:chemistry*; D015018:Ytterbium / Q000737:chemistry*
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; C472765:Globo-H; D009844:Oligosaccharides; D015018:Ytterbium