Immune pre-activation exacerbates hemorrhagic brain injury in immature mouse brain.
Premature infants with placental infection and adult stroke patients with fever have worse outcomes following intracerebral hemorrhage (ICH). We hypothesized that immune pre-activation would aggravate brain injury in mouse brain following ICH. The immune system of 2-day, 10-day and 7-week young adult CD1 mice was stimulated by intraperitoneal injection of concanavalin A (ConA), lipopolysaccharide (LPS) or polyinosinic-polycytidilic acid (PolyI:C) 12 h prior to intracerebral injection of blood. Two days later, brain damage and inflammation were worse in 2-day mice that had received LPS. The other agents had less consistent effects in 2-day mice. Brain damage in young adults was aggravated less after immune stimulation. These data suggest that immune pre-activation modifies hemorrhagic brain injury in immature mouse brain.
Xue
Mengzhou
M
Department of Pathology, University of Manitoba and Manitoba Institute of Child Health, D212-770 Bannatyne Ave, Winnipeg, MB, Canada, R3E 0W3.
Del Bigio
Marc R
MR
D000375:Aging / Q000276:immunology / Q000473:pathology; D000818:Animals; D000831:Animals, Newborn; D001803:Blood Transfusion; D001921:Brain / Q000098:blood supply / Q000276:immunology* / Q000473:pathology*; D002543:Cerebral Hemorrhage / Q000276:immunology* / Q000401:mortality / Q000473:pathology*; D003208:Concanavalin A / Q000008:administration & dosage; D005260:Female; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D007371:Interferon-gamma / Q000172:deficiency / Q000235:genetics; D008070:Lipopolysaccharides / Q000008:administration & dosage; D008213:Lymphocyte Activation / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011070:Poly I-C / Q000008:administration & dosage
D008070:Lipopolysaccharides; D003208:Concanavalin A; D007371:Interferon-gamma; D011070:Poly I-C