Effects of famotidine, mosapride and tandospirone for treatment of functional dyspepsia.
BACKGROUND
An effective therapeutic strategy for functional dyspepsia (FD) has not been well-established.


OBJECTIVE
We investigated and compared the therapeutic effects of famotidine, mosapride and tandospirone for the control of dyspeptic symptoms.


METHODS
Fully examined FD patients of outpatient clinics at seven different medical centres were enrolled in the study. They were randomly assigned to three groups based on the type of drug administered: famotidine, mosapride and tandospirone. The effects of treatment over 4 weeks were assessed by visual analogue scales.


RESULTS
All of the drugs showed beneficial effects, although famotidine was the most effective for symptom relief, which was significantly greater than tandospirone, while the effect of mosapride was similar to that of famotidine. No subtype of FD showed a better response to a particular type of drug.


CONCLUSIONS
For the treatment of FD, famotidine demonstrated the best therapeutic effect, followed by mosapride, while that of tandospirone was significantly lower.
Kinoshita
Y
Y
Department of Gastroenterology and Hepatology, Shimane University School of Medicine, Izumo-shi, Shimane, Japan. kinosita@med.shimane-u.ac.jp
Hashimoto
T
T
Kawamura
A
A
Yuki
M
M
Amano
K
K
Sato
H
H
Adachi
K
K
Sato
S
S
Oshima
N
N
Takashima
T
T
Kitajima
N
N
Abe
K
K
Suetsugu
H
H
D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001549:Benzamides / Q000627:therapeutic use*; D004415:Dyspepsia / Q000188:drug therapy*; D015738:Famotidine / Q000627:therapeutic use*; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D054833:Isoindoles; D008297:Male; D008875:Middle Aged; D009025:Morpholines / Q000627:therapeutic use*; D010879:Piperazines / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D016896:Treatment Outcome
D014151:Anti-Anxiety Agents; D000897:Anti-Ulcer Agents; D001549:Benzamides; D005765:Gastrointestinal Agents; D006635:Histamine H2 Antagonists; D054833:Isoindoles; D009025:Morpholines; D010879:Piperazines; D011743:Pyrimidines; C055267:tandospirone; D015738:Famotidine; C062720:mosapride