title: Risk factors for spontaneous rupture of liver abscess caused by Klebsiella pneumoniae.
abstract: To identify risk factors for spontaneous rupture of liver abscess (SRLA), a retrospective study on patients with liver abscess caused by Klebsiella pneumoniae was performed. Of the 140 enrolled patients with liver abscess caused by K. pneumoniae, 8 (5.7%) experienced SRLA. In comparison to those with nonruptured liver abscess (NRLA), patients with SRLA were found to have significantly higher proportions of diabetic mellitus (100% versus 62.1%, P = 0.003), larger abscess size (mean of maximal diameter 7.8 versus 6.1 cm, P = 0.043), gas formation in abscess (87.5% versus 23.5%, P < 0.001), and left hepatic lobe involvement (50.0% versus 16.5%, P = 0.018). K. pneumoniae serotypes K1 and K2 were the predominant microorganisms isolated in both patients with NRLA and SRLA. Pulsed-field gel electrophoresis-generated fingerprinting of K. pneumoniae isolates from patients with SRLA revealed that these pathogens were nongenetically related.
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Taiwan 833, ROC.
authors.forename: Chen-Hsiang
authors.initials: CH
authors.lastname: Lee
authors.forename: Hsieh-Shong
authors.initials: HS
authors.lastname: Leu
authors.forename: Ting-Shu
authors.initials: TS
authors.lastname: Wu
authors.forename: Lin-Hui
authors.initials: LH
authors.lastname: Su
authors.forename: Jien-Wei
authors.initials: JW
authors.lastname: Liu
mesh_terms: D000368:Aged; D016172:DNA Fingerprinting; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D006801:Humans; D007710:Klebsiella Infections / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology*; D007711:Klebsiella pneumoniae / Q000235:genetics / Q000254:growth & development*; D008100:Liver Abscess / Q000175:diagnosis / Q000382:microbiology* / Q000473:pathology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012422:Rupture, Spontaneous / Q000175:diagnosis / Q000382:microbiology; D018709:Statistics, Nonparametric; D013624:Taiwan; D014057:Tomography, X-Ray Computed
chemical_list: D004269:DNA, Bacterial