Recollection of vivid memories after perirhinal region stimulations: synchronization in the theta range of spatially distributed brain areas.
Electrical stimulation of the temporal cortex in patients with epilepsy sometimes elicits experiential phenomena such as recollection of vivid memories. The neurophysiological substrate of such phenomena is poorly understood. Furthermore, the relation between the site of stimulation and the type of memory elicited has only recently started to be investigated. We investigated these issues in patient FGA who had intracerebral electrodes stereotaxically implanted in the right temporal lobe for investigation of drug-resistant epilepsy. We report the results of electrical stimulations of the perirhinal region. Two stimulations elicited experiential phenomena consisting of visual memories that belonged to FGA's past, but which were not related to any particular episode. These visual memories consisted of objects or of details of objects. These two stimulations were contrasted with other stimulations in the same subhippocampal region. Cross-correlation analysis of the depth-EEG signals filtered in frequency sub-bands revealed that experiential phenomena occurred only when the various brain structures involved in the after-discharge were synchronized in the theta range. These structures included the perirhinal region, the hippocampus, other limbic structures as well as a primary visual area. Our results suggest that recollection of vivid memory after electric stimulation of the cortex may rely on wide networks of brain areas that transiently synchronize. These results also highlight the role of the perirhinal region in human memory. Experiential phenomena are rarely obtained after brain stimulation. Replication of these results is thus required due to the small number of observations reported.
Barbeau
Emmanuel
E
Laboratoire de Neurophysiologie et de Neuropsychologie, INSERM EMI-U 9926, Faculté de Médecine, 27 Boulevard Jean Moulin, 13385 Marseille, France. emmanuel.barbeau@medecine.univ.mrs.fr
Wendling
Fabrice
F
Régis
Jean
J
Duncan
Roderick
R
Poncet
Michel
M
Chauvel
Patrick
P
Bartolomei
Fabrice
F
D000328:Adult; D001931:Brain Mapping; D016022:Case-Control Studies; D004558:Electric Stimulation / Q000379:methods*; D004569:Electroencephalography / Q000379:methods / Q000528:radiation effects; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology* / Q000628:therapy*; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008568:Memory / Q000528:radiation effects*; D009483:Neuropsychological Tests; D010775:Photic Stimulation / Q000379:methods; D013238:Stereotaxic Techniques; D013702:Temporal Lobe / Q000528:radiation effects*