title: Brief communication: morphoproteomic analysis of osteolytic Langerhans cell histiocytosis with therapeutic implications.
abstract: Morphoproteomics utilizes immunohistochemistry to identify protein analytes in tumor cells in order to uncover or confirm potential molecular pathways that may be essential to their proliferation, integrity, and histogenesis and that may serve as therapeutic targets. This communication illustrates the application of such an approach to osteolytic Langerhans cell histiocytosis and considers such molecular targets in the context of currently available therapies.
authors.affiliation: Division of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822-0131, USA. rebrown@geisinger.edu
authors.forename: Robert E
authors.initials: RE
authors.lastname: Brown
mesh_terms: D006644:Histiocytes / Q000378:metabolism / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D010010:Osteoclasts / Q000378:metabolism / Q000473:pathology; D010014:Osteolysis / Q000378:metabolism / Q000473:pathology*; D020543:Proteome / Q000378:metabolism*
chemical_list: D020543:Proteome