title: Genetic lesions within the 3a gene of SARS-CoV.
abstract: A series of frameshift mutations within the 3a gene has been observed in culture-derived severe acute respiratory syndrome coronavirus (SARS-CoV). We report here that viral RNA from clinical samples obtained from SARS-CoV infected patients also contains a heterogeneous population of wild-type and mutant 3a transcripts.
authors.affiliation: Institute of Molecular and Cell Biology, 61 Biopolis Drive, 138673, Singapore. ttan@imcb.a-star.edu.sg
authors.forename: Timothy H P
authors.initials: TH
authors.lastname: Tan
authors.forename: Timothy
authors.initials: T
authors.lastname: Barkham
authors.forename: Burtram C
authors.initials: BC
authors.lastname: Fielding
authors.forename: Chih-Fong
authors.initials: CF
authors.lastname: Chou
authors.forename: Shuo
authors.initials: S
authors.lastname: Shen
authors.forename: Seng Gee
authors.initials: SG
authors.lastname: Lim
authors.forename: Wanjin
authors.initials: W
authors.lastname: Hong
authors.forename: Yee-Joo
authors.initials: YJ
authors.lastname: Tan
mesh_terms: D016368:Frameshift Mutation; D006801:Humans; D012367:RNA, Viral / Q000235:genetics; D045473:Severe acute respiratory syndrome-related coronavirus / Q000235:genetics* / Q000302:isolation & purification*; D045169:Severe Acute Respiratory Syndrome / Q000821:virology*; D014759:Viral Envelope Proteins; D014764:Viral Proteins / Q000235:genetics*; D000086082:Viroporin Proteins
chemical_list: C487105:3a protein, SARS-CoV; D012367:RNA, Viral; D014759:Viral Envelope Proteins; D014764:Viral Proteins; D000086082:Viroporin Proteins