[Guillain-Barré syndrome and non-Hodgkin's lymphoma. Report of one case and review of literature].
Patients with lymphoma frequently develop neurologic abnormalities mainly due to nervous system infiltration but also direct drug toxicity. Moreover Guillain-Barré syndrome (GBS) remains a possible neuropathy, rarely described in non-Hodgkin's lymphoma. We describe a case of GBS in a patient with non-Hodgkin's high grade lymphoma. A 74-year old man with a newly diagnosed stage I high-grade lymphoma (precursor B-cell Burkitt like type according to the R.E.A.L. Classification) develop flaccid quadriparesis, 7 days after the end of the third course of CHOP treatment. The clinical course and neurological examination were consistent with GBS. The patient was in tumoral complete response. Despite appropriate treatment and a transfer in a reanimation unit, the patient died 3 days after the beginning of neurologic symptoms. The low number of cases described in the international literature doesn't permit to understand the association of this neurologic disease with non-Hodgkin's lymphoma. Collecting more data could lead interesting information to know the place of malignant hematological disease in the natural history of GBS.
Magné
N
N
Départment d'Oncologie médicale, Institut Jules Bordet, U.L.B., Bruxelles.
Foa
C
C
Castadot
P
P
Otto
J
J
Birtwisle-Peyrottes
I
I
Thyss
A
A
D000368:Aged; D002051:Burkitt Lymphoma / Q000150:complications*; D020275:Guillain-Barre Syndrome / Q000150:complications*; D006801:Humans; D008297:Male