title: Tourette's syndrome and deep brain stimulation.
abstract: In this prospective double blind randomised "N of 1" study, a patient with a severe form of Tourette's syndrome was treated with bilateral high frequency stimulation of the centromedian-parafascicular complex (Ce-Pf) of the thalamus, the internal part of the globus pallidus (GPi), or both. Stimulation of either target improved tic severity by 70%, markedly ameliorated coprolalia, and eliminated self injuries. Severe forms of Tourette's syndrome may benefit from stimulation of neuronal circuits within the basal ganglia, thus confirming the role of the dysfunction of limbic striato-pallido-thalamo-cortical systems in this disorder.
authors.affiliation: Centre d'Investigation Clinique, Hôpital de la Salpêtrière, 47 boulevard de l'Hôpital, 75013 Paris, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Houeto
authors.forename: C
authors.initials: C
authors.lastname: Karachi
authors.forename: L
authors.initials: L
authors.lastname: Mallet
authors.forename: B
authors.initials: B
authors.lastname: Pillon
authors.forename: J
authors.initials: J
authors.lastname: Yelnik
authors.forename: V
authors.initials: V
authors.lastname: Mesnage
authors.forename: M L
authors.initials: ML
authors.lastname: Welter
authors.forename: S
authors.initials: S
authors.lastname: Navarro
authors.forename: A
authors.initials: A
authors.lastname: Pelissolo
authors.forename: P
authors.initials: P
authors.lastname: Damier
authors.forename: B
authors.initials: B
authors.lastname: Pidoux
authors.forename: D
authors.initials: D
authors.lastname: Dormont
authors.forename: P
authors.initials: P
authors.lastname: Cornu
authors.forename: Y
authors.initials: Y
authors.lastname: Agid
mesh_terms: D000328:Adult; D004292:Dominance, Cerebral / Q000502:physiology; D004599:Electric Stimulation Therapy; D004567:Electrodes, Implanted; D005260:Female; D005500:Follow-Up Studies; D005917:Globus Pallidus / Q000503:physiopathology*; D006801:Humans; D020646:Intralaminar Thalamic Nuclei / Q000503:physiopathology*; D009460:Neurologic Examination; D011446:Prospective Studies; D016728:Self-Injurious Behavior / Q000503:physiopathology / Q000628:therapy; D012920:Social Behavior Disorders / Q000503:physiopathology / Q000628:therapy; D005879:Tourette Syndrome / Q000503:physiopathology / Q000628:therapy*