title: Childhood craniopharyngioma: Vancouver experience.
abstract: OBJECTIVE
  To present our institution's experience in the management of childhood craniopharyngioma since 1982.
  
  
  METHODS
  We retrospectively reviewed the records of all children diagnosed with craniopharyngioma at our children's hospital from its opening in 1982 through to 2003. One neuroradiologist systematically reviewed the neuroimaging. Kaplan-Meier curves were used to analyze the progression-free survival and the overall survival from the time of the first definitive intervention.
  
  
  CONCLUSIONS
  Most children diagnosed with craniopharyngioma are long-term survivors. Survivors suffer from multiple deficits in the long term. A conservative surgical and radiotherapeutic approach and avoiding interventions that are known to cause severe morbidity may minimize these. The use of intracystic bleomycin is a strategy that allows the delay of more aggressive therapies in select patients.
authors.affiliation: Division of Neurology and Oncology, British Columbia Children's Hospital, 4480 Oak St., Vancouver, V6H 3V4, Canada. jhukin@cw.bc.ca
authors.forename: Juliette
authors.initials: J
authors.lastname: Hukin
authors.forename: Johann
authors.initials: J
authors.lastname: Visser
authors.forename: Michael
authors.initials: M
authors.lastname: Sargent
authors.forename: Karen
authors.initials: K
authors.lastname: Goddard
authors.forename: Chris
authors.initials: C
authors.lastname: Fryer
authors.forename: Paul
authors.initials: P
authors.lastname: Steinbok
mesh_terms: D000293:Adolescent; D002170:Canada; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003397:Craniopharyngioma / Q000628:therapy*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007016:Hypophysectomy / Q000379:methods; D007223:Infant; D008297:Male; D010910:Pituitary Irradiation; D010911:Pituitary Neoplasms / Q000628:therapy*; D011183:Postoperative Complications; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome