title: Placental site trophoblastic tumor of the mediastinum.
abstract: Choriocarcinoma has been described as the most frequent subtype of mediastinal germ cell tumors showing trophoblastic differentiation. We report a unique case of a placental site trophoblastic tumor, which developed in the mediastinum of a 14-year-old boy 2 years after the resection of a mature teratoma. The recurrent tumor was composed of a grossly hemorrhagic and necrotic mass. Histologically, diffusely infiltrating large polygonal cells with focal nodular growth and a teratomatous part containing mature intestinal, respiratory, and squamous epithelium with adjacent cutaneous adnexal structures were found. The typical morphologic features included vessel wall infiltration by the neoplastic cells with fibrinoid deposits and geographic necroses within the tumor masses. Characteristic diffuse positivity for melanoma cell adhesion molecule and human leucocyte antigen G was found on immunohistochemical investigation, confirming the diagnosis of placental site trophoblastic tumor. The patient died 1 year later after polychemotherapy. The outcome of this rare tumor is similar to the reported poor clinical outcome in patients with mediastinal choriocarcinomas.
authors.affiliation: Institute of Pathology, University Hospital of Basel, Switzerland.
authors.forename: Philip Th
authors.initials: PT
authors.lastname: Went
authors.forename: Stephan
authors.initials: S
authors.lastname: Dirnhofer
authors.forename: Thoman
authors.initials: T
authors.lastname: Stallmach
authors.forename: Christian
authors.initials: C
authors.lastname: Taverna
authors.forename: Gad
authors.initials: G
authors.lastname: Singer
mesh_terms: D000293:Adolescent; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008479:Mediastinal Neoplasms / Q000378:metabolism / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000473:pathology*; D011247:Pregnancy; D013724:Teratoma / Q000473:pathology; D018245:Trophoblastic Tumor, Placental Site / Q000378:metabolism / Q000473:pathology*; D014594:Uterine Neoplasms / Q000378:metabolism / Q000473:pathology*