Synthesis of poly-O-sulfated glycosides of 2,5-anhydro-D-mannitol.
2,5-Anhydro-3-O-beta-D-glucopyranosyl-; -3-O-alpha-L-idopyranosyl-; -3-O-alpha-D-arabinopyranosyl-; -3-O-alpha-L-arabinopyranosyl-; -3-O-beta-D-maltopyranosyl-; -3-O-beta-D-gentiobiopyranosyl-; -1,6-di-O-beta-D-glucopyranosyl-; -1,6-di-O-alpha-L-idopyranosyl-; -1-O-beta-D-maltopyranosyl-; -1,3,6-tri-O-beta-D-glucopyranosyl-; -1,6-di-O-beta-maltopyranosyl- and -1,6-di-O-beta-D-gentiobiopyranosyl-2,5-anhydro-D-mannitol as well as their poly-O-sulfated derivatives were synthesized. The IP3-IC50 values of their sodium and/or potassium salts were determined for structure-activity studies aiming at the synthesis of new, orally active antiasthmatic compounds.
Kuszmann
János
J
IVAX Drug Research Institute, H-1325 Budapest, PO Box 82, Hungary. janos.kuszmann@idri.hu
Medgyes
Gábor
G
Boros
Sándor
S
D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry*; D008353:Mannitol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D013431:Sulfates / Q000737:chemistry*
D006027:Glycosides; D013431:Sulfates; D008353:Mannitol; C031765:2,5-anhydromannitol