title: [Effect of vertebral body stiffness before and after vertebroplasty on intradiscal pressure].
abstract: Fractures of osteoporotic vertebral bodies are increasingly stabilized with bone cement. The effects of vertebral-body stiffness before and after augmentation with bone cement and of wedge-shaped vertebral body fractures on intradiscal pressure are insufficiently known. In a finite element model of the lumbar spine the elastic modulus of cancellous bone as well as the amount and the elastic modulus of bone cement were varied and the dependency of intradiscal pressure on these parameters was calculated. In addition, a wedge-shaped vertebral-body fracture was simulated. The bulge of the vertebral-body endplate and thus the intradiscal pressure depends strongly on the grade of osteoporosis in the vertebral body. The influence of amount and elastic modulus of bone cement on intradiscal pressure is small. A wedge-shaped vertebral-body fracture causes an anterior shift of upper-body centre of gravity. If this shift is not compensated, it leads to an increased flexion moment that has to be balanced by muscle forces. In addition, this shift leads to a stronger increase of intradiscal pressure than the augmentation of the vertebral body with bone cement.
authors.affiliation: Biomechanik-Labor, Charité- Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin. rohlmann@biomechanik.de
authors.forename: A
authors.initials: A
authors.lastname: Rohlmann
authors.forename: T
authors.initials: T
authors.lastname: Zander
authors.lastname: Jony
authors.forename: U
authors.initials: U
authors.lastname: Weber
authors.forename: G
authors.initials: G
authors.lastname: Bergmann
mesh_terms: D001843:Bone Cements / Q000627:therapeutic use*; D003198:Computer Simulation; D004548:Elasticity / Q000187:drug effects; D006801:Humans; D007403:Intervertebral Disc / Q000187:drug effects* / Q000503:physiopathology*; D007796:Laminectomy; D008159:Lumbar Vertebrae / Q000187:drug effects* / Q000503:physiopathology* / Q000601:surgery; D008954:Models, Biological; D011312:Pressure; D013314:Stress, Mechanical
chemical_list: D001843:Bone Cements