Genetic polymorphism in the sulfotransferase SULT1A1 gene in cancer.
Cytosolic sulfotransferases are enzymes that catalyze the conjugation of sulfate groups to a variety of xenobiotic and endogenous substrates. A mutation in the SULT1A1 gene has been associated with decreased sulfotransferase activity. We studied 125 cancer patients and 100 healthy controls from Brazil matched by age and gender. The objective of this study was to assess the impact of the SULT1A1 polymorphism on sulfotransferase activity in a population of cancer patients. Both heterozygous and homozygous individuals for the mutant allele had significantly decreased sulfotransferase enzymatic activity. This decrease was more significant in cancer patients. The frequency of the SULT1A1( *)2 allele was increased in the myeloma group (odds ratio=0.53). These data suggest a functional role for the SULT1A1 gene polymorphism in cancer.
Pereira
Wogelsanger O
WO
Departamento de Bioquímica, Universidade Federal de São Paulo, São Paulo, Brazil.
Paiva
Aldair S
AS
Queiroz
José W
JW
Toma
Leny
L
Dietrich
Carl P
CP
Nader
Helena B
HB
Jerônimo
Selma M B
SM
D000328:Adult; D000368:Aged; D015239:Arylsulfotransferase / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics*; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA
D015239:Arylsulfotransferase; C117544:SULT1A1 protein, human