title: Evaluation of Ki-67 and p53 expression in primary and repeated liver metastases of GISTs.
abstract: There has been little research evaluating changes related to tumor cell proliferation between primary and metastatic tumors of gastrointestinal tumors in the same case. We herein report the case of a 50-year-old woman with a gastric gastrointestinal stromal tumor (GIST), who developed metastatic liver tumors three times in the 7 years after proximal gastrectomy for GIST. The primary and all the metastatic liver tumors, except the second, showed fascicular/storiform architecture and the short spindle cell type. The diffuse epithelioid cell proliferation was observed in the second metastatic liver tumor. Although the immunostaining pattern with respect to GIST differentiation markers had been preserved in the primary tumor as well as in all of the metastatic tumors, the latter showed weaker positivity of both Ki-67 and p53 than the primary GIST. The primary tumor showed diffuse positive p53, and the highest value of Ki-67 labeling index (LI) among them. The metastatic liver tumors showed focal, negative or sporadic positive appearances of p53, however, Ki-67 LI were scattering among them. Immunohistochemical assessment of Ki-67 LI and p53 might be useful for evaluating changes related to tumor cell proliferation between primary and metastatic tumors of GISTs.
authors.affiliation: Department of Frontier Surgery (M9), Graduate School of Medicine, Chiba University, Japan. gunjim9@faculty.chiba-u.jp
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Gunji
authors.forename: Takashi
authors.initials: T
authors.lastname: Nikaidou
authors.forename: Sinichi
authors.initials: S
authors.lastname: Okazumi
authors.forename: Hisahiro
authors.initials: H
authors.lastname: Matsubara
authors.forename: Hideaki
authors.initials: H
authors.lastname: Shimada
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Nabeya
authors.forename: Taito
authors.initials: T
authors.lastname: Aoki
authors.forename: Haruhumi
authors.initials: H
authors.lastname: Makino
authors.forename: Shinichi
authors.initials: S
authors.lastname: Miyazaki
authors.forename: Takenori
authors.initials: T
authors.lastname: Ochiai
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D002455:Cell Division; D005260:Female; D005500:Follow-Up Studies; D046152:Gastrointestinal Stromal Tumors / Q000235:genetics / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D019394:Ki-67 Antigen / Q000235:genetics*; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000235:genetics / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D008197:Lymph Node Excision; D008875:Middle Aged; D011379:Prognosis; D012086:Reoperation; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53