title: [Junctional epithelialization of dental implants in animals].
abstract: To detect the histological changes and the expression of proliferating cell nuclear antigen (PCNA) in junctional epithelialization of dental implants.
  
  
  
  The junctional epithelium was detected by HE staining and the PCNA expression was observed by immunohistochemical staining on the st, 3rd, 6th, 9th, 12th, 15th, 20th and 30th day after implantation in Beagle dogs.
  
  
  
  The junctional epithelium began to form and PCNA was expressed positively 12 days after implantation. The epithelial hyperplasia tended to stabilization and the expression of PCNA weakened drastically 15 days after implantation. The epithelial attachment showed to be similar to that of natural teeth 20 days later.
  
  
  
  The gingiva epithelium can attach to titanium implants forming junctional epithelium which is similar to the natural teeth.
authors.affiliation: The Affiliated Stomatology Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China. LL225@zju.edu.cn
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Li-ming
authors.initials: LM
authors.lastname: Zhang
authors.forename: Xiao-cong
authors.initials: XC
authors.lastname: Zhag
mesh_terms: D000818:Animals; D003757:Dental Implantation; D015921:Dental Implants; D004285:Dogs; D004846:Epithelial Attachment; D005260:Female; D008297:Male; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis*; D014025:Titanium
chemical_list: D015921:Dental Implants; D018809:Proliferating Cell Nuclear Antigen; D014025:Titanium