Elevated levels of CRP in ovarian hyperstimulation syndrome: an unrecognised potential hazard?
OBJECTIVE
Elevated levels of C-reactive protein (CRP) were found recently to be a crucial marker for cardiovascular disease. This protein might have a role in endothelial cell activation, vascular damage and a thrombotic tendency. We sought to determine whether concentrations of CRP are altered in women with controlled ovarian hyperstimulation (COH) or hyperstimulation syndrome (OHSS).


METHODS
A prospective cohort study.


METHODS
The gynecology department and IVF unit of the Lis maternity hospital.


METHODS
Twenty women with OHSS, 20 women undergoing COH and 20 women who participated as controls were included in the study.


METHODS
Venous blood was withdrawn for analysis of high sensitive C-reactive protein (hs-CRP) using the Boering BN-II nephelometer.


METHODS
hs-CRP levels were determined.


RESULTS
There was a significant (P < 0.05) difference in the hs-CRP concentrations in women with OHSS compared with women with COH and controls. The respective values for hs-CRP were 19.0 [4.0], 7.0 [1.7] and 4.6 [1.1] mg/L.


CONCLUSIONS
Women with OHSS have elevated concentrations of hs-CRP. This finding, previously believed to merely represent an acute phase response, may actually represent a yet unrecognised pathophysiological factor of this syndrome and pave the way for new investigational directions of this potentially hazardous condition.
Levin
Ishai
I
Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel.
Gamzu
Ronni
R
Pauzner
David
D
Rogowski
Ori
O
Shapira
Itzhak
I
Maslovitz
Sharon
S
Almog
Benny
B
D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000378:metabolism*; D011446:Prospective Studies; D018709:Statistics, Nonparametric
D015415:Biomarkers; D002097:C-Reactive Protein