[Relationship between prognosis of nasal inverted papilloma and human papillomavirus types].
OBJECTIVE
To detected HPV human papillomavirus DNA and HPV types in NIP nasal inverted papilloma, to inquire into the infection of HPV in the pathogenesis of NIP, and the relationship of HPV with the prognosis of NIP.


METHODS
Twenty-eight cases of NIP were divided into 3 groups: no recurrence group (group 1), recurrence group (group 2), squamous cell carcinoma (SCC) arising in NIP group (malignancy group, group 3). Ten cases of benign nasal polyps were used as control group. HPV-DNA types of 6, 11, 16, 18 and general type were detected by polymerase chain reaction (PCR).


RESULTS
Total positive rate of HPV in NIP was 75% (21/28). The positive rate of group 1 was 42% (5/12), all with single and low risk HPV type infection (4 with HPV6 and 1 with HPV11). Thirteen cases of recurrence and 3 cases of malignancy were discovered to have HPV-DNA, in group 2, the majority were HPV6 and HPV11, 4 cases with double infection;in group 3, the majority were HPV16 and HPV18, and 2 cases with double infection.


CONCLUSIONS
The occurrence of NIP was related with HPV infection. To detected HPV and its subtypes can show the cases easily to have recurrence or malignant change. For the cases with HPV positive, double infection and infected with high risk types should be closely followed-up.
Lu
Shan-shan
SS
Department of Pathology, First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China. ss66ss33@sina.com.cn
Zou
Ren
R
Xu
Ji-wei
JW
D016022:Case-Control Studies; D006801:Humans; D009669:Nose Neoplasms / Q000175:diagnosis / Q000821:virology*; D018308:Papilloma, Inverted / Q000175:diagnosis / Q000821:virology*; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics*; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000821:virology*; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis / Q000821:virology*; D011379:Prognosis