N-Substituted acridone alkaloids from Toddaliopsis bremekampii (Rutaceae: Toddalioideae) of south-central Africa.
Toddaliopsins A-D, four novel 1,2,3-trioxygenated acridone alkaloids, have been isolated from the leaves of Toddaliopsis bremekampii. Toddaliopsins B-D are the first reported acridone alkaloids with substituted N-methyl groups, in the light of which the chemotaxonomic relationship of Toddaliopsis and Vepris is discussed. Toddaliopsin C possesses moderate anti-inflammatory activity, which may be related to the hydroxy group present at C-1.
Naidoo
Dashnie
D
School of Chemistry, University of KwaZulu-Natal, Howard College Campus, Durban 4041, South Africa.
Coombes
Philip H
PH
Mulholland
Dulcie A
DA
Crouch
Neil R
NR
van den Bergh
Albert J J
AJ
D000166:Acridines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D054831:Acridones; D000349:Africa; D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008163:Luminescent Measurements; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects; D018515:Plant Leaves / Q000737:chemistry; D027821:Rutaceae / Q000737:chemistry*
D000166:Acridines; D054831:Acridones; D000470:Alkaloids; C041300:acridone