MTP1 mops up excess zinc in Arabidopsis cells.
The MTP1 protein of Arabidopsis thaliana belongs to a ubiquitous family of transition metal transporters that extrude metal ions from the cytoplasm. In a recent publication, Yoshihiro Kobae and colleagues show that AtMTP1 localizes to the vacuolar membrane in Arabidopsis roots and suspension-cultured cells. They demonstrate that the mtp1-1 mutant is hypersensitive to zinc and complement the mutant by transforming it with the MTP1 coding sequence downstream of a constitutive (35S) promoter.
Krämer
Ute
U
Max Planck Institute of Molecular Plant Physiology, Am Mühlenberg 1, D-14476 Golm, Germany. kraemer@mpimp-golm.mpg.de
D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D027682:Cation Transport Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D008658:Inactivation, Metabolic; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D015032:Zinc / Q000493:pharmacokinetics*
D029681:Arabidopsis Proteins; D027682:Cation Transport Proteins; D015032:Zinc; C500829:ZAT protein, Arabidopsis