title: [Acute cerebral circulation problems].
abstract: Acute stroke is the third most common cause of death and also the most common cause of permanent disability in industrialized countries. Ischemic stroke is caused by occlusion of a cerebral artery leading to a critical reduction in brain perfusion in the respective brain area (penumbra). Most acute stroke treatment strategies are based on the penumbra concept: attaining rapid and persistent reperfusion is followed by the protection of critically ischemic and not yet infarcted (penumbral) tissue by, e.g., neuroprotection. Examination of the acute stroke patient includes a brief history, neurostatus and imaging (CT or MRI) for the exclusion of intracerebral hemorrhage. The diagnostic standard is CT; modern stroke MRI protocols provide an improved selection in later time windows. Intravenous thrombolysis with rt-PA within 3 h of symptom onset is the only approved therapy with a proven significant benefit for the patient. The effect is smaller but still significant if treatment occurs up to 4.5 h, and may still be present in MRI selected patients up to 9 h. More aggressive forms of therapy include interventional reperfusion techniques and therapy of malignant MCA infarction such as hemicraniectomy and hypothermia, which at present, however, are not routine and are only performed in specialized centers.
authors.affiliation: Neurologische Klinik, Universitätsklinikum Heidelberg. Peter_Schellinger@med.uni-heidelberg.de
authors.forename: P D
authors.initials: PD
authors.lastname: Schellinger
authors.forename: R
authors.initials: R
authors.lastname: Kollmar
authors.forename: U K
authors.initials: UK
authors.lastname: Meyding-Lamadé
authors.forename: J B
authors.initials: JB
authors.lastname: Fiebach
authors.forename: W
authors.initials: W
authors.lastname: Hacke
mesh_terms: D000208:Acute Disease; D002561:Cerebrovascular Disorders / Q000175:diagnosis* / Q000628:therapy*; D003422:Critical Care / Q000379:methods; D003937:Diagnosis, Differential; D004635:Emergency Medicine / Q000379:methods; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D011379:Prognosis; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D015912:Thrombolytic Therapy / Q000379:methods; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator