[Study on the dynamics of IgG antibody in 311 patients with severe acute respiratory syndrome].
OBJECTIVE
To detect the level and dynamic change of severe acute respiratory syndrome (SARS)-coronavirus-specific IgG antibody in conavalescent SARS patients, and to provide information for prevention and vaccine development.


METHODS
IgG antibody against coronavirus was detected by ELISA in the blood of 311 convalescent SARS patients for every 2 - 4 weeks. Stata 7.0 statistics software was used to analyse the results.


RESULTS
IgG antibody was detected positive on each testing of all the convalescent patients and its peak appeared 35 days after recovery. IgG antibody level showed a 35.8% decrease within one year.


CONCLUSIONS
Data showed that all the SARS convalescent patients had generated high level of specific IgG antibody against coronavirus in the early stage of recovery, but the antibody level declined along with the progress of convalescence, suggesting that the detection of the IgG antibody should go on until it disappeared.
Fan
Bao-xing
BX
Department of Respiratory Disease, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
Xie
Li-xin
LX
Chen
Liang-an
LA
Chen
Wei-jun
WJ
Wen
Jie
J
Liu
You-ning
YN
D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D003289:Convalescence; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D045473:Severe acute respiratory syndrome-related coronavirus / Q000276:immunology; D045169:Severe Acute Respiratory Syndrome / Q000276:immunology*
D000914:Antibodies, Viral; D007074:Immunoglobulin G