title: Novel cytotoxic monotetrahydrofuranic Annonaceous acetogenins from Annona montana.
abstract: Four new monotetrahydrofuranic Annonaceous acetogenins, montalicins G (1) and H (2) and monlicins A (3) and B (4), and two new linear acetogenins, (+)-monhexocin (5) and (-)-monhexocin (6), as well as three known compounds, murisolin (7), 4-deoxyannomontacin (8), and muricatacin (9), were isolated from the seeds of Annona montana by high performance liquid chromatographic (HPLC) method. The absolute stereochemical structures of new isolates were elucidated and characterized by spectral and chemical methods. Interestingly, these compounds show special cytotoxicity against human hepatoma cells, Hep G2.
authors.affiliation: Graduate Institute of Natural Products, Kaohsiung Medical University, 100, Shih-Chuan 1st Road, Kaohsiung, Taiwan.
authors.forename: Chih-Chuang
authors.initials: CC
authors.lastname: Liaw
authors.forename: Fang-Rong
authors.initials: FR
authors.lastname: Chang
authors.forename: Shu-Li
authors.initials: SL
authors.lastname: Chen
authors.forename: Chin-Chung
authors.initials: CC
authors.lastname: Wu
authors.forename: Kuo-Hsiung
authors.initials: KH
authors.lastname: Lee
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
mesh_terms: D054378:Acetogenins; D031041:Annona / Q000737:chemistry*; D045744:Cell Line, Tumor; D005233:Fatty Alcohols / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000633:toxicity*; D005663:Furans / Q000737:chemistry*; D006801:Humans; D006859:Hydrogen / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000633:toxicity*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: D054378:Acetogenins; D005233:Fatty Alcohols; D005663:Furans; D007783:Lactones; D006859:Hydrogen