Rifampin-resistant meningococcal disease.
Rifampin-resistant meningococcal disease occurred in a child who had completed rifampin chemoprophylaxis for exposure to a sibling with meningococcemia. Susceptibility testing of 331 case isolates found only 1 other case of rifampin-resistant disease in Minnesota, USA, during 11 years of statewide surveillance. Point mutations in the RNA polymerase Beta subunit (rpoB) gene were found in isolates from each rifampin-resistant case-patient.
Rainbow
Jean
J
Minnesota Department of Health, Minneapolis, Minnesota 55414, USA. jean.rainbow@health.state.mn.us
Cebelinski
Elizabeth
E
Bartkus
Joanne
J
Glennen
Anita
A
Boxrud
Dave
D
Lynfield
Ruth
R
D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology*; D002648:Child; D012321:DNA-Directed RNA Polymerases / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008589:Meningococcal Infections / Q000188:drug therapy / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D008910:Minnesota; D009345:Neisseria meningitidis / Q000187:drug effects* / Q000302:isolation & purification; D017354:Point Mutation; D011159:Population Surveillance; D012293:Rifampin / Q000494:pharmacology* / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D012321:DNA-Directed RNA Polymerases; C105078:RNA polymerase beta subunit; D012293:Rifampin