title: Photodynamic activity of dibiotinylated aluminum sulfophthalocyanine in vitro and in vivo.
abstract: The photodynamic activity of dibiotinylated aluminum sulfophthalocyanine was studied in vitro and in vivo. Dibiotinylated aluminum sulfophthalocyanine provided enhanced phototoxic action on OAT-75 cell monolayers as compared with the parent drug. Photodynamic therapy of mice with Ehrlich carcinoma using dibiotinylated aluminum sulfophthalocyanine (0.25 mg/kg) resulted in enhanced inhibition of tumor growth, pronounced vascular damage (thrombosis and destruction of vascular walls) and eventual tumor necrosis.
authors.affiliation: Laboratory of Physical Biochemistry, A.N.Bach Institute of Biochemistry of Russian Academy of Sciences, Leninsky prospect, Moscow.
authors.forename: Irina G
authors.initials: IG
authors.lastname: Meerovich
authors.forename: Victoriav
authors.initials: V
authors.lastname: Jerdeva
authors.forename: Valentina M
authors.initials: VM
authors.lastname: Derkacheva
authors.forename: Gennady A
authors.initials: GA
authors.lastname: Meerovich
authors.forename: Eugeny A
authors.initials: EA
authors.lastname: Lukyanets
authors.forename: Eugenia A
authors.initials: EA
authors.lastname: Kogan
authors.forename: Alexander P
authors.initials: AP
authors.lastname: Savitsky
mesh_terms: D000535:Aluminum / Q000494:pharmacology* / Q000528:radiation effects*; D000818:Animals; D001710:Biotin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D019921:Biotinylation; D018288:Carcinoma, Small Cell; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D008027:Light; D008175:Lung Neoplasms; D051379:Mice; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D007211:Indoles; D017319:Photosensitizing Agents; C505721:dibiotinylated aluminum sulfophthalocyanine; D001710:Biotin; D000535:Aluminum