title: Angioedema acute hypersensitivity reaction to injectable hyaluronic acid.
abstract: BACKGROUND
  Injectable hyaluronic acid was introduced to European markets in 1996 and has demonstrated a high safety profile. We describe the first reported case of angioedema-type hypersensitivity following injection of the upper lip with non-animal-stabilized hyaluronic acid (NASHA) gel.
  
  
  OBJECTIVE
  To report a case and discuss a potential mechanism for and treatment of angioedema-type hypersensitivity following injection with NASHA gel into the upper lip.
  
  
  METHODS
  Not applicable.
  
  
  RESULTS
  Not applicable.
  
  
  CONCLUSIONS
  Although injectable hyaluronic acid has a high safety profile, this reaction is dramatic. Treatments and potential mechanisms are discussed.
authors.affiliation: Center for Dermatologic Surgery, Cooper University Hospital, Marlton, New Jersey 08053, USA.
authors.forename: Janie M
authors.initials: JM
authors.lastname: Leonhardt
authors.forename: Naomi
authors.initials: N
authors.lastname: Lawrence
authors.forename: Rhoda S
authors.initials: RS
authors.lastname: Narins
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000009:adverse effects*; D000799:Angioedema / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D005260:Female; D005782:Gels; D006560:Herpes Labialis / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000009:adverse effects*; D015552:Injections, Intralesional; D008875:Middle Aged
chemical_list: D000276:Adjuvants, Immunologic; D005782:Gels; D006820:Hyaluronic Acid