title: Therapeutic perspectives of adipocytokines.
abstract: Various adipocyte-secreted factors have been described which profoundly affect insulin sensitivity and might potentially link obesity, insulin resistance and cardiovascular disease. Among those, adiponectin, visfatin and omentin appear as insulin-sensitising adipocytokines, whereas TNF-alpha, IL-6 and resistin induce insulin resistance. Moreover, leptin is a fat-derived key regulator of appetite and energy expenditure. Due to their profound effect on whole-body glucose and energy metabolism, adipocytokines have attracted interest as potential new therapeutics for diabetes mellitus and obesity. The current knowledge on function, regulation and therapeutic potential of various adipocytokines, as well as their clinical implications, are discussed in this review.
authors.affiliation: Department of Internal Medicine III, University of Leipzig, Ph.-Rosenthal-Str.27, 04103 Leipzig, Germany.
authors.forename: Susan
authors.initials: S
authors.lastname: Kralisch
authors.forename: Johannes
authors.initials: J
authors.lastname: Klein
authors.forename: Matthias
authors.initials: M
authors.lastname: Bluher
authors.forename: Ralf
authors.initials: R
authors.lastname: Paschke
authors.forename: Michael
authors.initials: M
authors.lastname: Stumvoll
authors.forename: Mathias
authors.initials: M
authors.lastname: Fasshauer
mesh_terms: D017667:Adipocytes / Q000378:metabolism*; D000818:Animals; D016207:Cytokines / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism; D036361:Peptide Hormones / Q000378:metabolism / Q000627:therapeutic use; D045162:Thiazolidinediones / Q000378:metabolism / Q000627:therapeutic use*
chemical_list: D016207:Cytokines; D036361:Peptide Hormones; D045162:Thiazolidinediones