Coevolution of cancer and stromal cellular responses.
It is now becoming apparent that multiple types of stromal cells, including macrophages, mast cells, adipocytes, and fibroblasts make pivotal contributions to carcinogenesis. In the May 6 issue of Cell, Orimo and colleagues (Orimo et al., 2005) show that carcinoma-associated fibroblasts can promote epithelial tumorigenesis by secreting the chemokine SDF-1alpha (CXCL12). SDF-1alpha stimulates carcinoma cell proliferation and recruitment of endothelial precursor cells.
Littlepage
Laurie E
LE
Department of Anatomy, University of California, San Francisco, CA 94143, USA.
Egeblad
Mikala
M
Werb
Zena
Z
D000818:Animals; D002135:Calcium-Binding Proteins / Q000378:metabolism; D002465:Cell Movement; D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000378:metabolism; D042783:Endothelial Cells / Q000166:cytology; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D059630:Mesenchymal Stem Cells / Q000166:cytology; D008954:Models, Biological; D009369:Neoplasms / Q000209:etiology / Q000378:metabolism*; D009389:Neovascularization, Pathologic / Q000209:etiology / Q000378:metabolism; D000071999:S100 Calcium-Binding Protein A4; D009418:S100 Proteins; D017154:Stromal Cells / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism / Q000502:physiology
C515255:CXCL12 protein, human; D002135:Calcium-Binding Proteins; D054377:Chemokine CXCL12; D019743:Chemokines, CXC; C515256:Cxcl12 protein, mouse; D000071999:S100 Calcium-Binding Protein A4; D009418:S100 Proteins; C470944:S100a4 protein, mouse; D016212:Transforming Growth Factor beta; D020780:Matrix Metalloproteinase 9