[The role of drug metabolizing enzymes in the effect and side-effect of the drugs].
The authors give an overview on the role of drug metabolizing enzymes in the effect and side-effect of drugs. They describe the properties of cytochrome P450 and other phase I enzymes (hydrolases, flavin-monooxygenases), as well as of phase II. enzymes (glucuronyl-, sulfate-, glutathione-, acetyl-, methyltranferases), their polymorphism, inductive and inhibition properties. The possible drug-drug interactions are discussed in detail.
Vereczkey
László
L
Magyar Tudományos Akadémia, Kémiai Kutatóközpont, Farmakobiokémiai Osztály, Budapest. vela@chemres.hu
Jemnitz
Katalin
K
Monostory
Katalin
K
Veres
Zsuzsa
Z
Kóbori
László
L
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000378:metabolism*; D004347:Drug Interactions; D004790:Enzyme Induction; D047309:Flavones / Q000378:metabolism; D006801:Humans; D006867:Hydrolases / Q000378:metabolism; D008780:Methyltransferases / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011110:Polymorphism, Genetic
D047309:Flavones; D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D008780:Methyltransferases; D006867:Hydrolases