Cephalosporin resistance among animal-associated Enterobacteria: a current perspective.
Beta-lactam antimicrobials are an important class of drugs used for the treatment of infection. Resistance can arise by several mechanisms, including the acquisition of genes encoding beta-lactamases from other bacteria, alterations in cell membrane permeability and over expression of endogenous beta-lactamases. The acquisition of beta-lactamase resistance genes by both Salmonella and Escherichia coli appears to be on the rise, which may pose potential problems for the treatment of infections in both human and animal medicine. The prudent use of clinically important antimicrobials is therefore critical to maintain their effectiveness. Where possible, the use of newer generation cephalosporins should be limited in veterinary medicine.
Batchelor
Miranda
M
Food and Environmental Safety Department, Veterinary Laboratories Agency, Woodham lane, Addlestone, Surrey, KT15 3NB, UK. m.batchelor@VLA.DEFRA.gsi.gov.uk
Threlfall
E John
EJ
Liebana
Ernesto
E
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018550:Cephalosporin Resistance; D002511:Cephalosporins / Q000494:pharmacology*; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification; D005516:Food Microbiology; D006801:Humans
D000900:Anti-Bacterial Agents; D002511:Cephalosporins