Chemokines in tumor progression and metastasis.
Although chemokines have been thought of primarily as leukocyte attractants, a growing body of evidence indicates that they also contribute to a number of tumor-related processes, such as tumor cell growth, angiogenesis/angiostasis, local invasion, and metastasis. The current knowledge of the possible involvement of chemokines and their receptors in these cellular events are reviewed here. The operating mechanism of chemokines in relation to metastatic processes in vivo are also discussed.
Tanaka
Toshiyuki
T
Laboratory of Immunodynamics, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, 2-2, Suita, 565-0871, Japan.
Bai
Zhongbin
Z
Srinoulprasert
Yuttana
Y
Yang
Bo-Gie
BG
Yang
Bogi
B
Hayasaka
Haruko
H
Miyasaka
Masayuki
M
D002470:Cell Survival; D018925:Chemokines / Q000502:physiology*; D018450:Disease Progression; D006801:Humans; D009362:Neoplasm Metastasis / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology* / Q000503:physiopathology*; D009389:Neovascularization, Pathologic; D019707:Receptors, Chemokine / Q000502:physiology*
D018925:Chemokines; D019707:Receptors, Chemokine