Polymer micelle with cross-linked ionic core.
This work reports the design of polymer micelles with cross-linked ionic cores that display high stability. Block ionomer complexes were utilized as a micellar template for the synthesis of the cross-linked micelles. Such micelles represent hydrophilic nanospheres of core-shell morphology. The core comprises a network of the cross-linked polyanions, which is surrounded by the shell of hydrophilic PEO chains.
Bronich
Tatiana K
TK
Department of Pharmaceutical Sciences and the Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 985830 Nebraska Medical Center, Omaha, NE 68198-5830, USA. tbronich@unmc.edu
Keifer
Paul A
PA
Shlyakhtenko
Luda S
LS
Kabanov
Alexander V
AV
D002118:Calcium / Q000737:chemistry; D002413:Cations, Divalent; D003432:Cross-Linking Reagents / Q000737:chemistry; D016503:Drug Delivery Systems; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry*; D019904:Polymethyl Methacrylate / Q000737:chemistry*
D002413:Cations, Divalent; D003432:Cross-Linking Reagents; D008823:Micelles; D011092:Polyethylene Glycols; D019904:Polymethyl Methacrylate; D002118:Calcium