title: Overview of BioCreAtIvE: critical assessment of information extraction for biology.
abstract: BACKGROUND
  The goal of the first BioCreAtIvE challenge (Critical Assessment of Information Extraction in Biology) was to provide a set of common evaluation tasks to assess the state of the art for text mining applied to biological problems. The results were presented in a workshop held in Granada, Spain March 28-31, 2004. The articles collected in this BMC Bioinformatics supplement entitled "A critical assessment of text mining methods in molecular biology" describe the BioCreAtIvE tasks, systems, results and their independent evaluation.
  
  
  RESULTS
  BioCreAtIvE focused on two tasks. The first dealt with extraction of gene or protein names from text, and their mapping into standardized gene identifiers for three model organism databases (fly, mouse, yeast). The second task addressed issues of functional annotation, requiring systems to identify specific text passages that supported Gene Ontology annotations for specific proteins, given full text articles.
  
  
  CONCLUSIONS
  The first BioCreAtIvE assessment achieved a high level of international participation (27 groups from 10 countries). The assessment provided state-of-the-art performance results for a basic task (gene name finding and normalization), where the best systems achieved a balanced 80% precision / recall or better, which potentially makes them suitable for real applications in biology. The results for the advanced task (functional annotation from free text) were significantly lower, demonstrating the current limitations of text-mining approaches where knowledge extrapolation and interpretation are required. In addition, an important contribution of BioCreAtIvE has been the creation and release of training and test data sets for both tasks. There are 22 articles in this special issue, including six that provide analyses of results or data quality for the data sets, including a novel inter-annotator consistency assessment for the test set used in task 2.
authors.affiliation: The MITRE Corporation, 202 Burlington Road, Bedford, MA 01730, USA. lynette@mitre.org
authors.forename: Lynette
authors.initials: L
authors.lastname: Hirschman
authors.forename: Alexander
authors.initials: A
authors.lastname: Yeh
authors.forename: Christian
authors.initials: C
authors.lastname: Blaschke
authors.forename: Alfonso
authors.initials: A
authors.lastname: Valencia
mesh_terms: D019295:Computational Biology / Q000379:methods*; D003625:Data Collection / Q000379:methods; D003628:Database Management Systems; D016208:Databases, Factual; D019451:Information Management / Q000379:methods; D038622:Internationality; D009626:Terminology as Topic