title: Chemokine and cytokine production in susceptible C3H/HeN mice and resistant BALB/c mice during Orientia tsutsugamushi infection.
abstract: To understand the pathogenesis of scrub typhus, we examined chemokine and cytokine production in susceptible (C3H/HeN) and resistant (BALB/c) mice after infection with O. tsutsugamushi Gilliam. C3H/HeN mice produced high levels of chemokines macrophage inflammatory proteins 1 alpha (MIP-1 alpha ), MIP-2, monocyte chemoattractant protein 1 (MCP-1), and cytokines gamma-interferon (IFN-gamma ), interleukin-12 (IL-12), IL-10, and tumor necrosis factor alpha (TNF-alpha ) in response to O. tsutsugamushi infection, compared to BALB/c mice. Chemokine profiles in infected mice correlated well with the kinetics of inflammatory cell infiltration. Hyperproduction of chemokines and cytokines was observed in another susceptible-infection model (BALB/c-Karp). These results suggest that hyperproduction of chemokines and cytokines are associated with susceptibility during O. tsutsugamushi infection.
authors.affiliation: Department of Microbiology, Cheju National University College of Medicine, Jeju, Republic of Korea.
authors.forename: Ji-Hyun
authors.initials: JH
authors.lastname: Yun
authors.forename: Young-Sang
authors.initials: YS
authors.lastname: Koh
authors.forename: Keun-Hwa
authors.initials: KH
authors.lastname: Lee
authors.forename: Jin-Won
authors.initials: JW
authors.lastname: Hyun
authors.forename: Yeon-Joo
authors.initials: YJ
authors.lastname: Choi
authors.forename: Won-Jong
authors.initials: WJ
authors.lastname: Jang
authors.forename: Kyung-Hee
authors.initials: KH
authors.lastname: Park
authors.forename: Nam-Hyuk
authors.initials: NH
authors.lastname: Cho
authors.forename: Seung-Yong
authors.initials: SY
authors.lastname: Seong
authors.forename: Myung-Sik
authors.initials: MS
authors.lastname: Choi
authors.forename: Ik-Sang
authors.initials: IS
authors.lastname: Kim
mesh_terms: D000818:Animals; D018925:Chemokines / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D016207:Cytokines / Q000096:biosynthesis* / Q000235:genetics; D016753:Interleukin-10 / Q000096:biosynthesis; D018664:Interleukin-12 / Q000096:biosynthesis; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D012285:Orientia tsutsugamushi; D012612:Scrub Typhus / Q000209:etiology / Q000235:genetics / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000235:genetics
chemical_list: D018925:Chemokines; D016207:Cytokines; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D018664:Interleukin-12