title: Scrotal Ulcers Arising during Treatment with All-trans Retinoic Acid for Acute Promyelocytic Leukemia.
abstract: All-trans retinoic acid (ATRA) is effective in approximately 90% of the cases of acute promyelocytic leukemia (APL) with a low incidence of adverse effects. We report a patient with APL who developed skin ulcers of the scrotum concomitant with high fever during treatment that included ATRA. Severe fever was promptly alleviated with discontinuation of ATRA, while the ulcers improved gradually over 3 months. As the clinical features are similar to those of Sweet's syndrome, we should be aware of the possibility that this rare adverse effect may occur in the treatment with ATRA.
authors.affiliation: Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Shimizu
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nomura
authors.forename: Ryuzo
authors.initials: R
authors.lastname: Matsuyama
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Kyoji
authors.initials: K
authors.lastname: Ueda
authors.forename: Koji
authors.initials: K
authors.lastname: Masuda
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Taki
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nishida
authors.forename: Shigeo
authors.initials: S
authors.lastname: Horiike
authors.forename: Saburo
authors.initials: S
authors.lastname: Kishimoto
authors.forename: Akio
authors.initials: A
authors.lastname: Yanagisawa
authors.forename: Masafumi
authors.initials: M
authors.lastname: Taniwaki
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001707:Biopsy, Needle; D001853:Bone Marrow / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D012611:Scrotum; D012883:Skin Ulcer / Q000139:chemically induced* / Q000473:pathology; D014212:Tretinoin / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D014212:Tretinoin