Possible novel index determined by the glucose clamp test for selection of a suitable therapy for each type 2 diabetic patient.
The hallmark of type 2 diabetes is insulin resistance and insufficient insulin secretion, and appropriate therapy should be selected for each patient. In this study, to establish some index to select suitable therapy for each patient, we evaluated insulin sensitivity and insulin secretion with euglycemic hyperinsulinemic clamp and hyperglycemic clamp tests, respectively, and found that specific GIR index (GIRxIRI (90)) could be a useful marker to select suitable therapy for each type 2 diabetic patient (GIR: glucose infusion rate in euglycemic hyperinsulinemic clamp test; IRI (90): plasma insulin level 90 min after starting the hyperglycemic clamp test).
Gorogawa
Shin-Ichi
S
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
Kaneto
Hideaki
H
Matsuhisa
Munehide
M
Ohtoshi
Kentaro
K
Kawamori
Dan
D
Hazama
Yoji
Y
Yoshiuchi
Kazutomi
K
Yamasaki
Yoshimitsu
Y
D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000145:classification / Q000628:therapy*; D005260:Female; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology; D015309:Glucose Clamp Technique / Q000379:methods*; D006801:Humans; D006943:Hyperglycemia; D006946:Hyperinsulinism; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007333:Insulin Resistance; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged
D001786:Blood Glucose; D007328:Insulin; D005947:Glucose