title: The mechanism and regulation of fat mobilization from adipose tissue: desnutrin, a newly discovered lipolytic enzyme.
abstract: A new member of a family of proteins functioning in the regulation of lipolysis in adipose tissue has been discovered and named "desnutrin." Desnutrin is transiently induced by fasting and decreased by re-feeding. A close homolog, termed adiponutrin, has the opposite expression pattern, being induced by feeding and disappearing upon fasting. Desnutrin functions by acting as the first enzyme in lipolysis, hydrolyzing triglycerides to diglycerides, whereas the well-known hormone-sensitive lipase takes the diglycerides to monoglycerides and on to free fatty acids.
authors.affiliation: Department of Nutritional Sciences and Toxicology, University of California, Berkeley, USA.
authors.forename: George
authors.initials: G
authors.lastname: Wolf
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D006801:Humans; D008049:Lipase; D008053:Lipid Mobilization / Q000502:physiology*; D008066:Lipolysis / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D014280:Triglycerides / Q000378:metabolism; D000217:Acyltransferases
chemical_list: D002265:Carboxylic Ester Hydrolases; D005230:Fatty Acids, Nonesterified; D008049:Lipase; D008565:Membrane Proteins; D014280:Triglycerides; C436316:adiponutrin; C494445:PNPLA2 protein, mouse; D000217:Acyltransferases