title: Making sense of nonsense: the evolution of selenocysteine usage in proteins.
abstract: A recent analysis of sequences derived from organisms in the Sargasso Sea has revealed a surprisingly different set of selenium-containing proteins than that previously found in sequenced genomes and suggests that selenocysteine utilization has been lost by many groups of organisms during evolution.
authors.affiliation: Department of Molecular Genetics, Microbiology and Immunology, UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA. paul.copeland@umdnj.edu
authors.forename: Paul R
authors.initials: PR
authors.lastname: Copeland
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry* / Q000378:metabolism*; D030562:Databases, Protein; D019143:Evolution, Molecular; D005798:Genes, Bacterial / Q000235:genetics; D017279:Selenocysteine / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D017279:Selenocysteine