Mechanism of the eosinophilic differentiation of HL-60 clone 15 cells induced by n-butyrate.
n-Butyrate is one of the most powerful chemical inducers of the differentiation of human eosinophilic leukemia HL-60 clone 15 cells into mature eosinophils. We have recently reported that the mechanism by which HL-60 clone 15 cells differentiate into eosinophils by n-butyrate is that n-butyrate continuously inhibits histone deacetylase activity as a histone deacetylase inhibitor, resulting in continuous acetylation of histones. In this review, we discuss roles of histone acetyltransferase, histone deacetylase and histone deacetylase inhibitors in the differentiation of HL-60 clone 15 cells into eosinophils.
Ishihara
Kenji
K
Laboratory of Pathophysiological Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Miyagi, Japan.
Hong
Jangja
J
Zee
Okpyo
O
Ohuchi
Kazuo
K
D000107:Acetylation / Q000187:drug effects; D000123:Acetyltransferases / Q000378:metabolism; D002087:Butyrates / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects* / Q000276:immunology; D002999:Clone Cells; D004804:Eosinophils / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D018922:HL-60 Cells; D051548:Histone Acetyltransferases; D056572:Histone Deacetylase Inhibitors; D006655:Histone Deacetylases / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D006801:Humans
D002087:Butyrates; D056572:Histone Deacetylase Inhibitors; D006657:Histones; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; D006655:Histone Deacetylases