title: Solution- and solid-phase synthesis of radicicol (monorden) and pochonin C.
abstract: A modular synthesis for pochonin C and radicicol is reported. The two natural products were prepared in seven and eight steps, respectively, from three readily available fragments. Alternative syntheses of these compounds were achieved using a combination of polymer-bound reagents and solid phase reactions. The conformation of the two natural products was studied and compared by using 2D NMR spectroscopy.
authors.affiliation: Organic and Bioorganic Chemistry Laboratory, Institut de Science et Ingénierie Supramoléculaires, Université Louis Pasteur, 8 allée Gaspard Monge, 67000 Strasbourg, France.
authors.forename: Sofia
authors.initials: S
authors.lastname: Barluenga
authors.forename: Emilie
authors.initials: E
authors.lastname: Moulin
authors.forename: Pilar
authors.initials: P
authors.lastname: Lopez
authors.forename: Nicolas
authors.initials: N
authors.lastname: Winssinger
mesh_terms: D007783:Lactones / Q000138:chemical synthesis*; D018942:Macrolides / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D007783:Lactones; D018942:Macrolides; C499498:pochonin C; C035359:monorden