"Cracked-mud" ciprofloxacin precipitates on a corneal graft.
The authors describe an extreme case of ciprofloxacin deposition on the corneal graft of a 67-year-old man with a history of penetrating keratoplasty for corneal ulcer and perforation, who presented with dense, gray deposits on the anterior corneal surface after being treated with ciprofloxacin for an epithelial defect. The deposits resolved after ciprofloxacin was discontinued. The non-physiologic pH of the drug formulation is thought to trigger corneal precipitates, and it remains to be seen whether fourth-generation fluoroquinolones will have a lower incidence of ocular precipitates.
Tanhehco
Tasha Y
TY
Duke University Eye Center, Duke University Medical Center, Durham, North Carolina 27710, USA.
Chiavetta
Stephen V
SV
Lee
Paul P
PP
Fowler
Amy M
AM
Afshari
Natalie A
NA
D000368:Aged; D000890:Anti-Infective Agents / Q000009:adverse effects*; D011232:Chemical Precipitation; D002939:Ciprofloxacin / Q000009:adverse effects*; D003315:Cornea / Q000187:drug effects*; D003316:Corneal Diseases / Q000139:chemically induced*; D016039:Corneal Transplantation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D012008:Recurrence; D014786:Vision Disorders / Q000209:etiology
D000890:Anti-Infective Agents; D002939:Ciprofloxacin