Biological implications of cell fusion.
Until recently, cells were thought to be integral and discrete components of tissues, and their state was determined by cell differentiation. However, under some conditions, stem cells or their progeny can fuse with cells of other types, mixing cytoplasmic and even genetic material of different (heterotypic) origins. The fusion of heterotypic cells could be of central importance for development, repair of tissues and the pathogenesis of disease.
Ogle
Brenda M
BM
Transplantation Biology and the Department of Physiology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Cascalho
Marilia
M
Platt
Jeffrey L
JL
D000375:Aging / Q000502:physiology; D000818:Animals; D002454:Cell Differentiation; D002459:Cell Fusion; D006801:Humans; D008954:Models, Biological; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*