Microwave-enhanced synthesis of N-shifted buflavine analogues via a Suzuki-ring-closing metathesis protocol.
[reaction: see text] A novel, microwave-enhanced six-step synthesis was devised for the synthesis of N-shifted buflavine analogues. Microwave-enhanced Suzuki-Miyaura cross-coupling and ring-closing metathesis reactions were used as the key steps. Microwave irradiation was found to enhance the ring-closing metathesis reaction to generate the otherwise difficultly obtainable medium-sized ring system of the target molecules.
Appukkuttan
Prasad
P
Department of Chemistry, University of Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.
Dehaen
Wim
W
Van der Eycken
Erik
E
D047151:Amaryllidaceae Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry*; D001392:Azocines / Q000138:chemical synthesis* / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D008872:Microwaves; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry
D047151:Amaryllidaceae Alkaloids; D001392:Azocines; C465299:buflavine