FoldIndex: a simple tool to predict whether a given protein sequence is intrinsically unfolded.
An easy-to-use, versatile and freely available graphic web server, FoldIndex is described: it predicts if a given protein sequence is intrinsically unfolded implementing the algorithm of Uversky and co-workers, which is based on the average residue hydrophobicity and net charge of the sequence. FoldIndex has an error rate comparable to that of more sophisticated fold prediction methods. Sliding windows permit identification of large regions within a protein that possess folding propensities different from those of the whole protein.
Prilusky
Jaime
J
Biological Services, Weizmann Institute of Science, Rehovot 76100, Israel.
Felder
Clifford E
CE
Zeev-Ben-Mordehai
Tzviya
T
Rydberg
Edwin H
EH
Man
Orna
O
Beckmann
Jacques S
JS
Silman
Israel
I
Sussman
Joel L
JL
D000465:Algorithms; D003196:Computer Graphics; D003198:Computer Simulation; D004735:Energy Transfer; D020407:Internet; D008956:Models, Chemical; D008958:Models, Molecular; D011487:Protein Conformation; D017510:Protein Folding; D011506:Proteins / Q000032:analysis / Q000737:chemistry*; D016415:Sequence Alignment / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*; D012984:Software; D013329:Structure-Activity Relationship; D014584:User-Computer Interface
D011506:Proteins