title: Determinants of circulating adiponectin in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  Adiponectin is regarded as a possible link between adiposity and insulin resistance. Ghrelin and leptin are considered as signals of energy status. We evaluated the relationships between these peptides, androgens and insulin sensitivity in women affected by polycystic ovary syndrome.
  
  
  METHODS
  Thirty-six women with PCOS were examined with euglycemic hyperinsulinemic clamp (to determine M/I, index of insulin sensitivity). Leptin, ghrelin, adiponectin, androgens, and SHBG were determined. Statistics was done using correlation analysis and backward stepwise multiple regression.
  
  
  RESULTS
  The positive correlation of adiponectin with testosterone remains significant even after adjustment for BMI (p = 0.01), M/I (p = 0.009) and for both M/I and BMI (p = 0.02). In multiple regression with testosterone, M/I, leptin and ghrelin as independent variables, the model including testosterone (p = 0.03) and ghrelin (p = 0.002) explained 49% of the variability (p < 0.0012) of adiponectin.
  
  
  CONCLUSIONS
  Both adiponectin and ghrelin can be involved in the pathophysiology of PCOS but their relation must be delineated further.
authors.affiliation: Institute of Endocrinology, Prague, Czech Republic. jvrbikova@endo.cz
authors.forename: Jana
authors.initials: J
authors.lastname: Vrbíková
authors.forename: Katerina
authors.initials: K
authors.lastname: Dvoráková
authors.forename: Martin
authors.initials: M
authors.lastname: Hill
authors.forename: Josef
authors.initials: J
authors.lastname: Vcelák
authors.forename: Sona
authors.initials: S
authors.lastname: Stanická
authors.forename: Markéta
authors.initials: M
authors.lastname: Vanková
authors.forename: Daniela
authors.initials: D
authors.lastname: Srámková
authors.forename: Karel
authors.initials: K
authors.lastname: Vondra
authors.forename: Bela
authors.initials: B
authors.lastname: Bendlová
authors.forename: Luboslav
authors.initials: L
authors.lastname: Stárka
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000728:Androgens / Q000097:blood; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D005260:Female; D054439:Ghrelin; D015309:Glucose Clamp Technique; D006801:Humans; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood; D008875:Middle Aged; D036361:Peptide Hormones / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000453:epidemiology; D012044:Regression Analysis; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood
chemical_list: D052242:Adiponectin; D000728:Androgens; D015415:Biomarkers; D054439:Ghrelin; D020738:Leptin; D036361:Peptide Hormones; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone