New synthetic route for the enantioselective total synthesis of salinosporamide A and biologically active analogues.
[reaction: see text] A total synthesis of the salinosporamide analogue 3 is described that starts with the novel cyclization 4 --> 5.
Reddy
Leleti Rajender
LR
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
Fournier
Jean-François
JF
Reddy
B V Subba
BV
Corey
E J
EJ
D002384:Catalysis; D003500:Cyclization; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism
D007783:Lactones; D011758:Pyrroles; C117645:omuralide; C475865:marizomib