title: Immunomodulation after allogeneic bone marrow transplantation by CD4+CD25+ regulatory T cells.
abstract: Graft-versus-host disease is a major complication after allogeneic bone marrow transplantation (BMT) caused by donor T cells. Immunosuppression mediated by CD4(+)CD25(+) regulatory T cells has been shown to ameliorate such pathogenic immune responses in animal models. Here, we summarize recent findings from experimental and clinical studies and propose a model for peripheral tolerance induction after BMT.
authors.affiliation: Institute of Immunology, University Hospital Regensburg, University of Regensburg, Germany.
authors.forename: Petra
authors.initials: P
authors.lastname: Hoffmann
authors.forename: Tina J
authors.initials: TJ
authors.lastname: Boeld
authors.forename: Biserka
authors.initials: B
authors.lastname: Piseshka
authors.forename: Matthias
authors.initials: M
authors.lastname: Edinger
mesh_terms: D000818:Animals; D016026:Bone Marrow Transplantation / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology*; D006086:Graft vs Host Disease / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D015375:Receptors, Interleukin-2 / Q000502:physiology*
chemical_list: D015375:Receptors, Interleukin-2