Enantioselective total synthesis of a novel polyketide natural product (+)-integrasone, an HIV-1 integrase inhibitor.
Enantioselective total synthesis of the recently isolated, novel polyketide natural product (+)-integrasone has been accomplished from the readily available Diels-Alder adduct of cyclopentadiene and p-benzoquinone. An enzymatically desymmetrized epoxyquinone building block has been elaborated through a series of regio- , chemo- and stereocontrolled steps to the final bicyclic framework of the natural product.
Mehta
Goverdhan
G
Department of Organic Chemistry, Indian Institute of Science, Bangalore. gm@orgchem.iisc.ernet.in
Roy
Subhrangsu
S
D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000494:pharmacology; D003500:Cyclization; D005663:Furans / Q000138:chemical synthesis* / Q000494:pharmacology; D019428:HIV Integrase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D015497:HIV-1; D013237:Stereoisomerism
D019086:Bridged Bicyclo Compounds, Heterocyclic; D005663:Furans; D019428:HIV Integrase Inhibitors; C487245:integrasone