Differential mRNA expression of neurotrophic factors GDNF, BDNF, and NT-3 in experimental herpes simplex virus encephalitis.
Glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) mRNA levels were studied in the course of murine herpes simplex virus encephalitis. Induction of GNDF and NT-3 (both P < 0.05) was found during acute encephalitis. Despite absence of clinical impairment, both neurotrophic factors were overexpressed 2 months (NT-3) and 6 months (GDNF) following infection (both P < 0.05). Neurotrophic factors play an important role in neuronal survival and recovery after acute injury to the central nervous system (CNS) and may represent an additional therapeutic target for treatment of viral encephalitis.
Sellner
Johann
J
Department of Neurology, Ruprecht-Karls-University Heidelberg, D-69120 Heidelberg, Germany. johann.sellner@ifik.unibe.ch
Lenhard
Thorsten
T
Haas
Jürgen
J
Einsiedel
Regina von
Rv
Meyding-Lamadé
Uta
U
D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology / Q000821:virology*; D001925:Brain Damage, Chronic / Q000503:physiopathology / Q000517:prevention & control / Q000821:virology; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics; D002470:Cell Survival / Q000235:genetics; D004195:Disease Models, Animal; D020803:Encephalitis, Herpes Simplex / Q000235:genetics* / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D015870:Gene Expression / Q000502:physiology; D051100:Glial Cell Line-Derived Neurotrophic Factor; D051379:Mice; D009410:Nerve Degeneration / Q000503:physiopathology / Q000517:prevention & control / Q000821:virology; D009414:Nerve Growth Factors / Q000235:genetics*; D020933:Neurotrophin 3 / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism*; D020127:Recovery of Function / Q000235:genetics
D019208:Brain-Derived Neurotrophic Factor; C495040:Gdnf protein, mouse; D051100:Glial Cell Line-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D020933:Neurotrophin 3; D012333:RNA, Messenger