Cell motility as persistent random motion: theories from experiments.
Experimental time series for trajectories of motile cells may contain so much information that a systematic analysis will yield cell-type-specific motility models. Here we demonstrate how, using human keratinocytes and fibroblasts as examples. The two resulting models reflect the cells' different roles in the organism, it seems, and show that a cell has a memory of past velocities. They also suggest how to distinguish quantitatively between various surfaces' compatibility with the two cell types.
Selmeczi
David
D
Danish Polymer Centre, and Biosystems Department, Risø National Laboratory, Roskilde, Denmark.
Mosler
Stephan
S
Hagedorn
Peter H
PH
Larsen
Niels B
NB
Flyvbjerg
Henrik
H
D002460:Cell Line; D002465:Cell Movement / Q000502:physiology*; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D015603:Keratinocytes / Q000166:cytology / Q000502:physiology*; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D008954:Models, Biological; D015233:Models, Statistical; D013269:Stochastic Processes