title: Acute renal failure in CF patients chronically infected by the Liverpool epidemic Pseudomonas aeruginosa strain (LES).
abstract: Although acute renal failure has been described in children with CF in relation to intravenous aminoglycoside use, there are no reports in the adult CF literature. We describe 8 cases of acute renal failure in adult CF patients, all occurring during the use of intravenous aminoglycosides for the treatment of pulmonary exacerbations with an epidemic multi-resistant Pseudomonas aeruginosa strain. Potential contributory factors are discussed. These cases demonstrate another complication of infection by epidemic Pseudomonas strains in CF, and confirm the need for effective segregation policies to prevent this.
authors.affiliation: The Cardiothoracic Centre, Liverpool, UK.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Al-Aloul
authors.forename: Helen
authors.initials: H
authors.lastname: Miller
authors.forename: Paul
authors.initials: P
authors.lastname: Stockton
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Ledson
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Walshaw
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000293:Adolescent; D000328:Adult; D000617:Aminoglycosides / Q000009:adverse effects* / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002908:Chronic Disease; D003550:Cystic Fibrosis / Q000188:drug therapy* / Q000382:microbiology; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification*; D012189:Retrospective Studies; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents