title: Quantification of L-type fatty acid binding protein in the urine of preterm neonates.
abstract: We measured urinary excretion of L-type fatty acid binding protein (L-FABP) in preterm neonates on days 1, 5-10, and 25-30 of life. Urinary L-FABP levels (expressed as the ratio to creatinine) in preterm neonates were considerably higher than those of healthy adults. They did not change significantly during the study period. Urinary L-FABP levels showed significant positive correlation with those of urinary N-acetyl-beta-D-glucosaminidase activity on day 1, and with those of 8-hydroxy-2'-deoxyguanosine on days 25-30. These results suggest that L-FABP is expressed in the neonatal kidney. Our results may also point to potential effects of proximal tubular damage and oxidative stress on urinary excretion of L-FABP.
authors.affiliation: Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Yoshida-gun, Fukui 910-1193, Japan. htsuka@fmsrsa.fukui-med.ac.jp
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Tsukahara
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sugaya
authors.forename: Kazuyo
authors.initials: K
authors.lastname: Hayakawa
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Mori
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hiraoka
authors.forename: Atsuko
authors.initials: A
authors.lastname: Hata
authors.forename: Mitsufumi
authors.initials: M
authors.lastname: Mayumi
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000118:Acetylglucosaminidase / Q000652:urine; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000652:urine*; D007668:Kidney / Q000378:metabolism
chemical_list: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000118:Acetylglucosaminidase; D003849:Deoxyguanosine