Evolution of antifungal-drug resistance: mechanisms and pathogen fitness.
Like other microorganisms, fungi exist in populations that are adaptable. Under the selection imposed by antifungal drugs, drug-sensitive fungal pathogens frequently evolve resistance. Although the molecular mechanisms of resistance are well-characterized, there are few measurements of the impact of these mechanisms on pathogen fitness in different environments. To predict resistance before a new drug is prescribed in the clinic, the full spectrum of potential resistance mutations and the interactions among combinations of divergent mechanisms can be determined in evolution experiments. In the search for new strategies to manage drug resistance, measuring the limits of adaptation might reveal methods for trapping fungal pathogens in evolutionary dead ends.
Anderson
James B
JB
Department of Botany, 3359 Mississauga Road North, University of Toronto, Mississauga, Ontario, Canada L5L 1C6. janderso@utm.utoronto.ca
D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D005075:Biological Evolution; D002176:Candida albicans / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity / Q000502:physiology; D025141:Drug Resistance, Fungal; D004843:Epistasis, Genetic; D005544:Forecasting; D005658:Fungi / Q000187:drug effects* / Q000472:pathogenicity / Q000502:physiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D009154:Mutation / Q000187:drug effects; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity / Q000502:physiology; D014774:Virulence / Q000187:drug effects
D000935:Antifungal Agents