[Misinterpretation of measured bicarbonates during the administration of high doses of propofol].
A patient, admitted to intensive care unit and sedated with propofol (Diprivan), had repeatedly presented severe decreased of measured bicarbonates without metabolic acidosis and with physiologic values of calculated bicarbonates. Consecutively to the administration of high doses of propofol, an important lactescence of samples had been observed and the tests realised showed that lactescence play a key role in the interference with the measurement of bicarbonates (as described in the literature). So, in the course of propofol administration, it would be advised to interpret with caution the results of measured bicarbonates to not conclude too quickly on a case of "propofol syndrome".
Grare
M
M
Laboratoire de biochimie et biologie moléculaire, Hôpital central, CHU Nancy. p.franck@chu-nancy.fr
Welfringer
P
P
Olivier
J L
JL
Franck
P
P
D000368:Aged; D001639:Bicarbonates / Q000097:blood*; D003951:Diagnostic Errors; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D008297:Male; D015742:Propofol / Q000008:administration & dosage*; D015203:Reproducibility of Results
D001639:Bicarbonates; D006993:Hypnotics and Sedatives; D015742:Propofol