title: [Dry eye syndrome in children with cystic fibrosis].
abstract: BACKGROUND
  Cystic fibrosis is a white Caucasian population specific disease, with autosomal recessive mode of inheritance. It is caused by mutations in the protein coding gene of chromosome 7, functioning as the cystic fibrosis transmembrane conductance regulator (CFTR), causing dysfunction of secretory glands in the alimentary tract, respiratory tract and in the eye.
  
  
  OBJECTIVE
  The aim of the study was to evaluate the tear film stability in cystic fibrosis patients.
  
  
  METHODS
  Fifteen patients with cystic fibrosis aged 8-23, mean age 13.05 +/- 3.45, and fifteen controls aged 8-21, mean age 13.56 +/- 3.45 were examined. The tests included slit-lamp biomacroscopy, tear film break-up time, fluorescein staining and lissamine green staining.
  
  
  RESULTS
  54% Cystic fibrosis patients showed a statistically significant abnormal break-up time results.
  
  
  CONCLUSIONS
  In cystic fibrosis patients we found low tear film stability. Fluorescine break-up time (FBUT) may be useful in the diagnosis of the dry eye in cystic fibrosis.
authors.affiliation: Klinika Okulistyki Dzieciecej, ul. Waszyngtona 17, 15-274 Białystok. mrugacz1@poczta.onet.pl
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Mrugacz
authors.forename: Alina
authors.initials: A
authors.lastname: Minorowska
authors.forename: Alina
authors.initials: A
authors.lastname: Bakunowicz-Lazarczyk
authors.forename: Nella
authors.initials: N
authors.lastname: Zywalewska
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D003550:Cystic Fibrosis / Q000150:complications*; D015352:Dry Eye Syndromes / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male