title: Psychiatric side effects during methysergide treatment.
abstract: A patient is reported with psychological change characterised by impaired concentration and thought projection, followed by both severe anxiety and depression, starting after three weeks on high dose methysergide. The acute problem settled slowly after methysergide withdrawal and is likely to represent an unusual and serious side effect of that drug.
authors.affiliation: Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, UK.
authors.forename: E
authors.initials: E
authors.lastname: Cittadini
authors.forename: P J
authors.initials: PJ
authors.lastname: Goadsby
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000139:chemically induced / Q000175:diagnosis; D001288:Attention / Q000187:drug effects*; D003027:Cluster Headache / Q000517:prevention & control*; D003702:Delusions / Q000139:chemically induced / Q000175:diagnosis; D003866:Depressive Disorder / Q000139:chemically induced / Q000175:diagnosis; D003937:Diagnosis, Differential; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006212:Hallucinations / Q000139:chemically induced / Q000175:diagnosis; D006801:Humans; D008297:Male; D008784:Methysergide / Q000009:adverse effects* / Q000627:therapeutic use; D010469:Perceptual Distortion; D011605:Psychoses, Substance-Induced / Q000175:diagnosis / Q000209:etiology*
chemical_list: D008784:Methysergide