[Kidney and glitazones].
PPARgamma nuclear receptors are mainly expressed in adipose tissue. However, they are also expressed in renal glomerular tissue and in vascular walls, thus participating through various and complex mechanisms, to glomerular and vascular sclerosis and to nephropathy development and progression. Studies carried out with glitazones, pharmacological agonists of nuclear receptor PPARgamma, in experimental models, either in vitro, or in vivo in animal models, have demonstrated their favourable effects on arterial blood pressure and on prevention and/or progression of diabetic nephropathy. The few clinical studies conducted in type 2 diabetic patients to assess these effects, are also in favor of a beneficial effect of glitazones on blood pressure and nephropathy in these patients. Thus, it appears extremely important and fully justified to conduct specific studies in patients with type 2 diabetes, with the aim to establish and to better characterize these effects in various clinical conditions (antihypertensive effect in treated hypertensive patients according to the class of antihypertensive agents used, prevention of diabetic nephropathy and/or effect on its progression, renal protection, etc.). Some adverse events, although with a low incidence, may be associated with glitazone use (weight gain, peripheral oedema, fluid retention, etc.), and may limit their use in some patients. It is clearly important to better understand the pathophysiological mechanisms of these effects and their possible long term consequences. Finally, it is important to emphasize the easiness to use glitazones in patients with renal insufficiency, without the need to adjust the drug regimen.
Deray
G
G
Service de Néphrologie, Groupe Hospitalier Pitié-Salpêtrière, F-75651 Paris Cedex 13, France. gilbert.deray@psl.ap-hop-paris.fr
Izzedine
H
H
Launay-Vacher
V
V
Bagnis
C
C
D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000517:prevention & control*; D004195:Disease Models, Animal; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D047495:PPAR gamma / Q000819:agonists; D045162:Thiazolidinediones / Q000494:pharmacology* / Q000627:therapeutic use
D047495:PPAR gamma; D045162:Thiazolidinediones