Interleukin-18 does not modulate the acute-phase response.
IL-18 is a pro-inflammatory cytokine of the IL-1 family and it induces IL-1, TNF, and IL-6, all of which are endogenous pyrogens. The pyrogenic properties of recombinant IL-18 were studied in a rabbit model of fever. rIL-18 did not cause fever when injected intravenously into rabbits. Furthermore, the ability of rIL-18 to modulate other components of the acute-phase response was assessed. rIL-18 did not induce leukocytosis, or changes of circulating concentrations of lipoproteins and corticosterone in mice. In conclusion, rIL-18 is not able to induce a febrile response in rabbits and does not modulate the acute-phase response in mice.
Stuyt
Rogier J L
RJ
Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Netea
Mihai G
MG
Verschueren
Ineke
I
Dinarello
Charles A
CA
Kullberg
Bart Jan
BJ
van der Meer
Jos W M
JW
D000210:Acute-Phase Reaction / Q000097:blood / Q000503:physiopathology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D003345:Corticosterone / Q000097:blood; D005334:Fever / Q000097:blood / Q000503:physiopathology; D005938:Glucocorticoids / Q000096:biosynthesis; D006801:Humans; D020382:Interleukin-18 / Q000494:pharmacology / Q000502:physiology*; D007958:Leukocyte Count; D007964:Leukocytosis / Q000503:physiopathology; D008055:Lipids / Q000097:blood; D051379:Mice; D008810:Mice, Inbred C57BL; D011817:Rabbits; D011994:Recombinant Proteins / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood
D005938:Glucocorticoids; D020382:Interleukin-18; D008055:Lipids; D011994:Recombinant Proteins; D014280:Triglycerides; D002784:Cholesterol; D003345:Corticosterone