title: [A case of prostate cancer diagnosed pathologically by bone metastatic site biopsy].
abstract: A 61-year-old man consulted our hospital complaining of high prostate specific antigen (PSA) value and difficulty to urinate. Prostate biopsy had been performed at another hospital, but did not reveal cancer. PSA was 18.5 ng/ml. Transrectal ultrasound-guided prostate biopsy was performed, but cancer was not detected. Later, PSA rose rapidly, and findings suggesting bone metastasis at right pubic bone and left sacro-ilial joint were found on computed tomography (CT), bone scintigraphy and magnetic resonance imaging (MRI). A repeat prostate biopsy was performed, but cancer was not detected from the prostate. On right pubic bone biopsy, poorly to moderately differentiated adenocarcinoma was detected. PSA immunohistochemical staining was positive, and the diagnosis was bone metastasis from prostate cancer. After endocrine therapy was started, PSA declined and bone metastasis disappeared on bone scintigraphy.
authors.affiliation: Department of Urology, Ashikaga Red Cross Hospital.
authors.forename: Seiji
authors.initials: S
authors.lastname: Nakata
authors.forename: Katsuya
authors.initials: K
authors.lastname: Nakano
authors.forename: Hirotomo
authors.initials: H
authors.lastname: Takahashi
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Shimizu
authors.forename: Hiroomi
authors.initials: H
authors.lastname: Higashi
authors.forename: Kazunari
authors.initials: K
authors.lastname: Ohki
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000556:secondary; D014408:Biomarkers, Tumor / Q000097:blood; D001706:Biopsy; D001859:Bone Neoplasms / Q000556:secondary*; D001842:Bone and Bones / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology; D011630:Pubic Bone
chemical_list: D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen