Design and simulation of active biochip system.
To solve the problems existing in passive biochip systems, we designed a novel active biochip system. This system introduces negative pressure and controlling devices to adjust the antigen-antibody reaction on the nitrocellulose membrane. Computational simulation demonstrated that this system is a rapid, stable, robust and practical system that may enhance the efficiency of antigen-antibody reactions and improve the repeatability and accuracy of biochip analysis.
Zhu
Wenwei
W
Institute of Genetic Diagnosis, The Fourth Military Medical University, Xi'an 710032, PR China. zhuwenwei428@hotmail.com
Zhu
Wenbiao
W
Zhang
Wenhong
W
Han
Fengchan
F
Dong
Xiuzhen
X
Yan
Xiaojun
X
D000936:Antigen-Antibody Complex / Q000032:analysis*; D001681:Biological Assay / Q000295:instrumentation* / Q000379:methods; D003198:Computer Simulation; D017076:Computer-Aided Design; D004867:Equipment Design / Q000379:methods*; D019544:Equipment Failure Analysis / Q000379:methods; D017022:Flow Injection Analysis / Q000295:instrumentation* / Q000379:methods; D007118:Immunoassay / Q000295:instrumentation* / Q000379:methods; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods; D008962:Models, Theoretical; D040081:Protein Array Analysis / Q000295:instrumentation* / Q000379:methods
D000936:Antigen-Antibody Complex