title: A case of reactive plasmacytosis mimicking multiple myeloma in a patient with primary Sjogren's syndrome.
abstract: Primary Sjogren's syndrome (pSS) is a chronic autoimmune disease with well-documented association of lymphoid malignancies during the progress of the disease. Although several types of malignancy and pseudomalignancy have been reported in pSS, low-grade non-Hodgkin's lymphomas are the most frequently observed. Reactive plasmacytosis mimicking myeloma is a very rare condition in association with pSS. We describe a 72-yr-old woman with pSS who presented with hypergammaglobulinemia, and extensive bone marrow and lymph node plasmacytosis, which mimicked multiple myeloma. In this patient, there was an abnormal differentiation of memory B cells to plasma cells in the peripheral blood suggesting underlying pathogenetic mechanism for this condition.
authors.affiliation: Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea. leejisoo@ewha.ac.kr
authors.forename: Jisoo
authors.initials: J
authors.lastname: Lee
authors.forename: Ji-Eun
authors.initials: JE
authors.lastname: Chang
authors.forename: Young-Joo
authors.initials: YJ
authors.lastname: Cho
authors.forename: Woon Seop
authors.initials: WS
authors.lastname: Han
mesh_terms: D000368:Aged; D018941:Antigens, CD19 / Q000032:analysis; D001856:Bone Marrow Examination; D003937:Diagnosis, Differential; D005260:Female; D005455:Fluorescent Antibody Technique / Q000379:methods; D006801:Humans; D009101:Multiple Myeloma / Q000473:pathology*; D010950:Plasma Cells / Q000737:chemistry / Q000473:pathology*; D012859:Sjogren's Syndrome / Q000473:pathology*; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000032:analysis
chemical_list: D018941:Antigens, CD19; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7