title: Maxillary sinus augmentation using a peptide-modified graft material in three mixtures: a prospective human case series of histologic and histomorphometric results.
abstract: This prospective study assessed vital bone quality and quantity after grafting maxillary sinuses with anorganic bone mineral containing a cell binding peptide (ABM/P-15) in combination with DFDBA (Mix I), hydrogel/ABM/P-15 (Mix II), or PRP (Mix III). Fifteen maxillary sinuses in 12 patients were grafted with the ABM/P-15 mixtures and after 4 to 5 months, cores were taken and analyzed histologically and histomorphometrically. Fifty-nine screw-type implants were placed. Mixes containing a spacer material (Mix I and II) produced greater average vital bone, more mature bone, and more interconnected bone bridges from the cortical (oral) end to the most apical portion, compared to a mix that lacked a spacer material (Mix III). None of the 59 implants failed with any graft material up to 5 months following implant placement. The study demonstrates that new trabecular bone is formed after grafting ABM/P-15 in the sinus floor; that more vital bone is formed when ABM/P-15 is mixed with a spacer material than without; and that implants can be successfully placed.
authors.affiliation: drgelbart@hotmail.com
authors.forename: Michael
authors.initials: M
authors.lastname: Gelbart
authors.forename: Robert
authors.initials: R
authors.lastname: Friedman
authors.forename: Vasile
authors.initials: V
authors.lastname: Burlui
authors.forename: Michael
authors.initials: M
authors.lastname: Rohrer
authors.forename: Brent
authors.initials: B
authors.lastname: Atkinson
mesh_terms: D000328:Adult; D000368:Aged; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D015519:Bone Density / Q000502:physiology; D018786:Bone Substitutes / Q000008:administration & dosage / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000473:pathology; D003238:Connective Tissue / Q000473:pathology; D015921:Dental Implants; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000627:therapeutic use; D008297:Male; D008437:Maxilla / Q000473:pathology / Q000601:surgery*; D008443:Maxillary Sinus / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D010012:Osteogenesis / Q000502:physiology; D017713:Platelet Transfusion; D011446:Prospective Studies
chemical_list: D018786:Bone Substitutes; D015921:Dental Implants; C403137:PepGen P-15; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate