Getting RIP'd Stunts Your Growth.
The p75 neurotrophin receptor (p75NTR) collaborates with the Nogo receptor (NgR) and LINGO-1 to activate RhoA in response to myelin-based growth inhibitors such as myelin-associated glycoprotein (MAG). In this issue of Neuron, Domeniconi et al., in a surprising turn, show that MAG induces intramembrane proteolysis (RIP) of p75NTR and find that p75NTR cleavage is required for MAG-induced RhoA activation and growth inhibition.
Ceni
Claire
C
Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Quebec, Canada.
Barker
Philip A
PA
D000818:Animals; D008954:Models, Biological; D018992:Myelin-Associated Glycoprotein / Q000494:pharmacology*; D016501:Neurites / Q000187:drug effects* / Q000378:metabolism; D009474:Neurons / Q000166:cytology*; D017434:Protein Structure, Tertiary / Q000502:physiology; D020742:rhoA GTP-Binding Protein / Q000378:metabolism
D018992:Myelin-Associated Glycoprotein; D020742:rhoA GTP-Binding Protein