[Dry eye syndrome in children with cystic fibrosis].
BACKGROUND
Cystic fibrosis is a white Caucasian population specific disease, with autosomal recessive mode of inheritance. It is caused by mutations in the protein coding gene of chromosome 7, functioning as the cystic fibrosis transmembrane conductance regulator (CFTR), causing dysfunction of secretory glands in the alimentary tract, respiratory tract and in the eye.


OBJECTIVE
The aim of the study was to evaluate the tear film stability in cystic fibrosis patients.


METHODS
Fifteen patients with cystic fibrosis aged 8-23, mean age 13.05 +/- 3.45, and fifteen controls aged 8-21, mean age 13.56 +/- 3.45 were examined. The tests included slit-lamp biomacroscopy, tear film break-up time, fluorescein staining and lissamine green staining.


RESULTS
54% Cystic fibrosis patients showed a statistically significant abnormal break-up time results.


CONCLUSIONS
In cystic fibrosis patients we found low tear film stability. Fluorescine break-up time (FBUT) may be useful in the diagnosis of the dry eye in cystic fibrosis.
Mrugacz
Małgorzata
M
Klinika Okulistyki Dzieciecej, ul. Waszyngtona 17, 15-274 Białystok. mrugacz1@poczta.onet.pl
Minorowska
Alina
A
Bakunowicz-Lazarczyk
Alina
A
Zywalewska
Nella
N
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D003550:Cystic Fibrosis / Q000150:complications*; D015352:Dry Eye Syndromes / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male