title: Galanin and galanin receptors in human cancers.
abstract: The increasing interest in peptides and peptide receptors in cancer is based on the possibility of receptor targeting, because peptide receptors are often expressed in different human tumors. The neuropeptide galanin has also been suggested to be involved in the development of neuroendocrine tumors based on the development of estrogen-induced tumors in estrogen-sensitive rats. This study summarizes our current knowledge on the expression of galanin peptide and galanin receptors in different human neuroendocrine tumors. The expression of both, peptide and corresponding receptor, seems to be a common feature of human gliomas, pheochromocytomas, pituitary and neuroblastic tumors. The co-expression of galanin and its receptors supports a role for galanin in tumor cell pathology via autocrine/paracrine mechanisms.
authors.affiliation: Department of Pediatrics, Paracelsus Private Medical University, Salzburg, Muellner-Hauptstrasse 48, A-5020 Salzburg, Austria.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Berger
authors.forename: Radmila
authors.initials: R
authors.lastname: Santic
authors.forename: Cornelia
authors.initials: C
authors.lastname: Hauser-Kronberger
authors.forename: Freimut H
authors.initials: FH
authors.lastname: Schilling
authors.forename: Per
authors.initials: P
authors.lastname: Kogner
authors.forename: Manfred
authors.initials: M
authors.lastname: Ratschek
authors.forename: Agnes
authors.initials: A
authors.lastname: Gamper
authors.forename: Neil
authors.initials: N
authors.lastname: Jones
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Sperl
authors.forename: Barbara
authors.initials: B
authors.lastname: Kofler
mesh_terms: D019004:Galanin / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology*; D044088:Receptors, Galanin / Q000502:physiology*
chemical_list: D044088:Receptors, Galanin; D019004:Galanin