[Clinical pathology, diagnosis, and treatment of mixed growth hormone-and prolactin cell adenoma].
OBJECTIVE
To discuss the clinical pathology and management of mixed growth hormone- and prolactin (GH-PRL) cell adenoma.


METHODS
Eight patients (4 men and 4 women, with the mean age of 32.3 year old and duration of symptoms 12 months) underwent examination of serum endocrine and magnetic resonance imaging. Clinical manifestations included headache, physiognomy of acromegalic patient, large pudgy hands and foots, menstrual dysfunction, amenorrhea, galactorrhea, and descending vision. Patients underwent transsphenoidal microsurgery of mixed GH-PRL pituitary adenoma between 1986 and 2004.


RESULTS
The hypersecretion of GH and PRL was relieved after operation. Headache was obviously improved in all patients. In 5 cases the menstrual dysfunction and amenorrhea were recovered. In 4 cases the galactorrhea and descending vision disappeared.


CONCLUSIONS
The diagnosis of mixed GH-PRL pituitary adenoma can be made according to the results examination of serum endocrine, pathology and clinical manifestations. Its endocrine features are related to the invasion extent of the adenoma. The transsphenoidal approach is the preferred treatment for mixed GH-PRL pituitary adenoma.
Wang
Ming-dong
MD
Department of Neurosurgery, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Ma
Wen-bin
WB
Guo
Mei
M
Shi
Yan-fang
YF
Wang
Hong
H
Wang
Ren-zhi
RZ
Yang
Di
D
Fang
Chuan
C
D000236:Adenoma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D000293:Adolescent; D000328:Adult; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D008297:Male; D010911:Pituitary Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D011388:Prolactin / Q000378:metabolism*; D015175:Prolactinoma / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology
D011388:Prolactin; D013006:Growth Hormone