title: The type of carbon dioxide absorbent has no relation to the concentration of carbon monoxide in the breathing circuit during low-flow isoflurane anaesthesia in smoking and non-smoking subjects.
abstract: The present study was designed to investigate the concentrations of carbon monoxide (CO) in the anaesthetic circuit and of arterial carboxyhaemoglobin (COHb) during low-flow isoflurane anaesthesia in smoking and non-smoking subjects using three kinds of cardon dioxide (CO2) absorbent. Thirty smoking and 30 non-smoking subjects were selected for this study, and these two groups were each divided into three groups according to the type of CO2 absorbent used (Wakolime A, Drägersorb Free, and Amsorb). Anaesthesia was maintained with 1.0% isoflurane and nitrous oxide (1. 0 l min(-1))/oxygen (1.0 l min(-1)). Concentrations of CO in the inspired breathing circuit and concentrations of arterial COHb were measured at 0, 1, 2, 3, and 4 hours after exposure to isoflurane. In the smoking groups there were no significant differences in CO concentrations in the circuit between the groups and the CO concentrations did not change significantly during the study period. There were also no significant differences in the arterial COHb values between the groups and the COHb concentrations remained constant. There was a significant linear correlation between the concentrations of CO and COHb (r=0.86, n =30, P<0.001). In the non-smoking groups all of the parameters remained constant at low levels that were independent of the type of CO2 absorbents tested. The major source for increased intraoperative CO exposure is related to the patient's smoking status, and the type of CO2 absorbent used has no relation to an increase in CO concentration in the breathing circuit.
authors.affiliation: Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yamakage
authors.forename: S I
authors.initials: SI
authors.lastname: Yoshida
authors.forename: S
authors.initials: S
authors.lastname: Iwasaki
authors.forename: M
authors.initials: M
authors.lastname: Mizu-Uchi
authors.forename: A
authors.initials: A
authors.lastname: Namiki
mesh_terms: D000042:Absorption; D000368:Aged; D000764:Anesthesia, Closed-Circuit / Q000295:instrumentation; D000768:Anesthesia, General / Q000295:instrumentation; D018685:Anesthetics, Inhalation; D002245:Carbon Dioxide; D002248:Carbon Monoxide / Q000032:analysis*; D002263:Carboxyhemoglobin / Q000032:analysis; D005260:Female; D006801:Humans; D007530:Isoflurane; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000378:metabolism*; D013997:Time Factors
chemical_list: D018685:Anesthetics, Inhalation; D002245:Carbon Dioxide; D002248:Carbon Monoxide; D002263:Carboxyhemoglobin; D007530:Isoflurane