Neutropenic enterocolitis in lung cancer: a report of two cases and a review of the literature.
The first patient, a 68-year-old woman, presented neutropenic fever and hemorrhagic diarrhea on the sixth day of a combination chemotherapy of carboplatin and paclitaxel. The second patient, a 30-year-old man, presented neutropenia and diarrhea on the tenth day of the second cycle of a combination chemotherapy of cisplatin and vinorelbine. In both patients, abdominal computed tomography scan showed thickening of the colon wall and pericolic edema, and the ultrasonography revealed echogenic thickening of the colon walls. These findings confirmed the diagnosis of neutropenic enterocolitis. After the treatments, we changed the anticancer drug regimen; and successfully achieved partial responses.
Furonaka
Makoto
M
Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Japan.
Miyazaki
Mitsuru
M
Nakajima
Masamistu
M
Hirata
Shintaro
S
Fujitaka
Kazunori
K
Kondo
Keiichi
K
Yokoyama
Akihito
A
Maeda
Hiroyuki
H
Kohno
Nobuoki
N
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003106:Colon / Q000000981:diagnostic imaging; D044504:Enterocolitis, Neutropenic / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents