Regular use of aspirin or acetaminophen and risk of non-Hodgkin lymphoma.
Regular use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been hypothesized to be associated with reduced risk of non-Hodgkin lymphoma (NHL), although previous results have been inconsistent. The current study investigated the effects of regular aspirin or acetaminophen use on non-Hodgkin lymphoma risk among 625 individuals with primary, incident NHL and 2512 age and sex matched hospital controls with non-neoplastic conditions who completed a comprehensive epidemiologic questionnaire. Results indicate that regular aspirin use may be associated with decreased NHL risk among men [adjusted odds ratio (aOR) 0.82, 95% confidence interval (CI), 0.65--1.04], but not among women (aOR 0.93, 95% CI, 0.71--1.23). In contrast, regular acetaminophen use was associated with elevated NHL risk among women (aOR 1.71, 95% CI, 1.18--2.50) but not among men (aOR 0.75, 95% CI, 0.48--1.17). Other studies have demonstrated that acetaminophen is associated with transient decreases in DNA repair, and lymphocytes may be particularly susceptible to DNA damage, suggesting a mechanism for the elevated NHL risk observed.
Baker
Julie A
JA
Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. kirsten.moysich@roswellpark.org
Weiss
Joli R
JR
Czuczman
Myron S
MS
Menezes
Ravi J
RJ
Ambrosone
Christine B
CB
Moysich
Kirsten B
KB
D000082:Acetaminophen / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use*; D016022:Case-Control Studies; D004249:DNA Damage; D004260:DNA Repair; D005260:Female; D006801:Humans; D015994:Incidence; D008214:Lymphocytes; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012737:Sex Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen; D001241:Aspirin