title: Electrochemically induced and controlled one-step covalent coupling reaction on self-assembled monolayers.
abstract: We report on a novel covalent coupling method using electrochemical activation of hydroquinone monoester self-assembled monolayers. The reaction generates benzoquinone as a good leaving group, followed by nucleophilic acyl substitution with a primary amine to form an amide in high yield. The method allows the site-selective and the reaction-controlled positioning of biotin on the individually addressable microelectrode array and, subsequently, density-differentiated patterning of streptavidin on the biotin surfaces. Because the electrochemical coupling method provides a very rapid, mild, and quantitatively controllable reaction pathway for covalent bond formation on organic surfaces, it will be used as a versatile molecular anchoring tool in fields such as molecular electronics and biochip technology.
authors.forename: Kyuwon
authors.initials: K
authors.lastname: Kim
authors.forename: Minchul
authors.initials: M
authors.lastname: Jang
authors.forename: Haesik
authors.initials: H
authors.lastname: Yang
authors.forename: Eunkyung
authors.initials: E
authors.lastname: Kim
authors.forename: Youn Tae
authors.initials: YT
authors.lastname: Kim
authors.forename: Juhyoun
authors.initials: J
authors.lastname: Kwak