title: Asymmetric synthesis of [7]helicene-like molecules.
abstract: [reaction: see text] A new approach to nonracemic [7]helicene-like molecules has been developed. Stereoselective Co(I)-mediated [2 + 2 + 2] cycloisomerization of aromatic triynes containing an asymmetric carbon atom produces [7]helicene-like scaffolds in diastereomeric ratios up to 100:0. This central-to-helical chirality transfer can be controlled by the absolute configuration at the asymmetric center and by the presence of carbon substituents.
authors.affiliation: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic. stara@uochb.cas.cz
authors.forename: Irena G
authors.initials: IG
authors.lastname: Stará
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Alexandrová
authors.forename: Filip
authors.initials: F
authors.lastname: Teplý
authors.forename: Petr
authors.initials: P
authors.lastname: Sehnal
authors.forename: Ivo
authors.initials: I
authors.lastname: Starý
authors.forename: David
authors.initials: D
authors.lastname: Saman
authors.forename: Milos
authors.initials: M
authors.lastname: Budesínský
authors.forename: Josef
authors.initials: J
authors.lastname: Cvacka