Tyramine-immunoreactive neuronal structures in the rat brain: abundance in the median eminence of the mediobasal hypothalamus.
Immunoreactivity to p-tyramine, one of the natural trace amines, was studied in the rat brain by an anti-p-tyramine antibody. Immunoreactivity to this amine is very weak in the nigrostriatal dopaminergic neurons and terminals, and weak in the locus coeruleus noradrenergic ones. It was intensified in these structures after monoamine oxidase inhibition. On the other hand, this amine was highly concentrated in the median eminence of the mediobasal hypothalamus, in which its physiological function on prolactin release has been demonstrated.
Kitahama
K
K
CNRS UMR5123, Laboratoire de Physiologie Intégrative Cellulaire et Moléculaire, Université Claude Bernard, Villeurbanne, France. kitahama@sommeil-univ-lyon1.fr
Araneda
S
S
Geffard
M
M
Sei
H
H
Okamura
H
H
D000818:Animals; D001142:Aromatic-L-Amino-Acid Decarboxylases / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008473:Median Eminence / Q000187:drug effects / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D051381:Rats; D013378:Substantia Nigra / Q000378:metabolism; D014439:Tyramine / Q000378:metabolism*
D008996:Monoamine Oxidase Inhibitors; D001142:Aromatic-L-Amino-Acid Decarboxylases; D004298:Dopamine; D014439:Tyramine