title: Do mice genetically selected for resistance to oral tolerance provide selective advantage for Schistosoma mansoni infection?
abstract: A highly evolved relationship exists between the parasitic flatworm Schistosoma mansoni and its vertebrate hosts that include the use of host immune signals by parasites. The S. mansoni infection was studied in two strains of mice genetically selected, over 18 generations of assortative mating, for extreme phenotypes of susceptibility (TS) and resistance (TR) to immunological tolerance. The objective was to observe whether the different host genetic backgrounds affected the outcome of experimental schistosomiasis. Fecal egg excretion, tissue egg count, worm recovery, and adult worm morphology and morphometry were monitored throughout the period of infection. TR mice presented total fecal egg excretion and thickness of tegument in adult male worms significantly higher than TS mice. Therefore, the comparative analysis of mice with extreme phenotypes of immunological response turns out to be useful in host-parasite relationship studies. Our results suggest that the TR mouse immunological profile provides a more favorable environment for the development of S. mansoni.
authors.affiliation: Cellular Biology and Genetics Department, Institute of Biology, Rio de Janeiro State University, Brazil.
authors.forename: José Roberto
authors.initials: JR
authors.lastname: Machado-Silva
authors.forename: Renata Heisler
authors.initials: RH
authors.lastname: Neves
authors.forename: Luciana Ormond
authors.initials: LO
authors.lastname: da Silva
authors.forename: Regina Maria Figueiredo
authors.initials: RM
authors.lastname: de Oliveira
authors.forename: Antonio Carlos
authors.initials: AC
authors.lastname: da Silva
mesh_terms: D000818:Animals; D001700:Biomphalaria; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D005243:Feces / Q000469:parasitology; D005260:Female; D006790:Host-Parasite Interactions; D007113:Immunity, Innate / Q000235:genetics*; D007422:Intestines / Q000469:parasitology; D008099:Liver / Q000469:parasitology; D008297:Male; D051379:Mice; D010270:Parasite Egg Count; D010641:Phenotype; D012550:Schistosoma mansoni / Q000033:anatomy & histology / Q000276:immunology / Q000302:isolation & purification; D012555:Schistosomiasis mansoni / Q000276:immunology*; D012641:Selection, Genetic