GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer.
Little is known about genetic risk factors for colorectal cancer. We assessed the association between polymorphisms in two genes involved in DNA repair of oxidative stress, GPX and OGG1, and risk of colorectal carcinoma or adenomas. We studied 166 cases with adenocarcinoma, 974 with adenomas and 397 controls recruited from the Norwegian cohort NORCCAP. No associations were found between the polymorphism GPX Pro198Leu and risk of colorectal adenomas or carcinomas. Carriers of the variant allele OGG1 Ser326Cys polymorphism had a lowered risk of colorectal cancer, OR=0.56 (95% confidence interval 0.33-0.95), while no association were found with risk of adenomas. This indicates that a low repair capacity of oxidative DNA damage may not be a risk factor for development of colorectal adenomas or carcinoma.
Hansen
Rikke
R
National Institute of Occupational Health, Copenhagen, Denmark.
Saebø
Mona
M
Skjelbred
Camilla Furu
CF
Nexø
Bjørn Andersen
BA
Hagen
Per Christian
PC
Bock
Günther
G
Bowitz Lothe
Inger Marie
IM
Johnson
Egil
E
Aase
Steinar
S
Hansteen
Inger-Lise
IL
Vogel
Ulla
U
Kure
Elin H
EH
D000230:Adenocarcinoma / Q000209:etiology* / Q000235:genetics*; D000236:Adenoma / Q000209:etiology / Q000235:genetics*; D000368:Aged; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000209:etiology / Q000235:genetics*; D004249:DNA Damage; D045647:DNA Glycosylases / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005979:Glutathione Peroxidase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009664:Norway; D018384:Oxidative Stress; D011110:Polymorphism, Genetic; D012307:Risk Factors
D005979:Glutathione Peroxidase; D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human