The use of relaxin improves healing in injured muscle.
To improve the functional recovery of injured skeletal muscle, we have focused our efforts on both enhancement of muscle regeneration and prevention of fibrosis. The polypeptide cytokine/growth factor relaxin can inhibit fibrous tissue formation in many tissues. As a member of the insulin-like growth factor family, relaxin also is a potential stimulator of muscle regeneration. In the current experiment, we examined the antifibrotic effect of relaxin in injured skeletal muscle. We also investigated if the injection of relaxin would influence muscle regeneration after injury. Our results demonstrate that relaxin treatment improved histologic and physiologic healing of muscles subjected to traumatic injury.
Li
Y
Y
Growth and Development Laboratory, Children's Hospital of Pittsburgh, Pittsburgh, PA 15213, USA.
Negishi
S
S
Sakamoto
M
M
Usas
A
A
Huard
J
J
D000818:Animals; D051379:Mice; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000293:injuries* / Q000473:pathology; D012065:Relaxin / Q000494:pharmacology* / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects*
D012065:Relaxin