title: Hyponatremia associated with repeated use of levetiracetam.
abstract: Levetiracetam (LEV) is increasingly used as adjunctive anticonvulsant therapy because of apparent low toxicity. Somnolence, asthenia, headache, dizziness, and nervousness are the most frequently reported side effects (1). We describe a patient, predisposed to the development of the syndrome of inappropriate antidiuretic hormone secretion (SIADH), in whom hyponatremia developed after two challenges of LEV.
authors.affiliation: Department of Neurology, Henry Ford Hospital, Detroit, Michigan 48202, USA. khalilnass@hotmail.com
authors.forename: Khalil
authors.initials: K
authors.lastname: Nasrallah
authors.forename: Brian
authors.initials: B
authors.lastname: Silver
mesh_terms: D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002220:Carbamazepine / Q000009:adverse effects / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000097:blood / Q000139:chemically induced*; D007177:Inappropriate ADH Syndrome / Q000097:blood / Q000139:chemically induced; D000077287:Levetiracetam; D010889:Piracetam / Q000009:adverse effects* / Q000031:analogs & derivatives*; D012964:Sodium / Q000097:blood
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine; D000077287:Levetiracetam; D012964:Sodium; D010889:Piracetam