A 13-week toxicity study of bismuth in rats by intratracheal intermittent administration.
Although bismuth is widely used as a lead substitute in the industrial field, the toxicity of bismuth by inhalation is little known. We performed a 13-wk intratracheal intermittent bismuth dose toxicity study. Bismuth was administered at dose levels of 0, 0.8, 4, 20 mg/kg to male Crj:CD(SD)IGS rats (SPF) by intratracheal intermittent administration once a week for thirteen weeks to investigate its potential toxic effects; especially for specific adverse effects and changes related to pre-neoplastic lesions. Our results showed foreign body inflammation in the lungs, which was caused by intratracheal administration of bismuth, and physical changes related to pulmonary lesions; however, there were no serious changes in other organs. We concluded that dose-dependent, but not specific adverse effects, were attributable to bismuth inhalation in the rat.
Sano
Yuri
Y
Department of Preventative Medicine and Public Health, School of Medicine, Keio University, Japan. sanoyuri@sc.itc.keio.ac.jp
Satoh
Hiroshi
H
Chiba
Momoko
M
Shinohara
Atsuko
A
Okamoto
Masahide
M
Serizawa
Koji
K
Nakashima
Hiroshi
H
Omae
Kazuyuki
K
D000280:Administration, Inhalation; D000818:Animals; D001729:Bismuth / Q000008:administration & dosage / Q000032:analysis / Q000633:toxicity*; D008168:Lung / Q000737:chemistry; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D001729:Bismuth