Lp-PLA2 inhibitory activities of fatty acid glycerols isolated from Saururus chinensis roots.
(R)-Glycerol-monolinoleate 4 and (R)-glycerol-monostearate 5 were isolated from the ethyl acetate extracts of Saururus chinensis roots and (R)- or (S)-fatty acid glycerols 4 and 5 were synthesized for confirming their structures and evaluating their inhibitory activities against Lp-PLA(2). The (R)-4 and (S)-4 exhibited Lp-PLA(2) inhibitory activities with IC(50) values of 45.0 and 52.0 microM, respectively.
Lee
Woo Song
WS
National Research Laboratory of Lipid Metabolism and Atherosclerosis, Korea Research Institute of Bioscience and Biotechnology, 52 Oun, Yusong, Daejeon 305-333, Republic of Korea.
Kim
Mi Jeong
MJ
Beck
Young-Il
YI
Park
Yong-Dae
YD
Jeong
Tae-Sook
TS
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D005989:Glycerides / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010741:Phospholipases A / Q000037:antagonists & inhibitors / Q000378:metabolism*; D054467:Phospholipases A2; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal; D032134:Saururaceae / Q000737:chemistry*
D005989:Glycerides; C048159:glyceryl monostearate; D010741:Phospholipases A; D054467:Phospholipases A2; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; C048627:monolinolein