The use of a continuous flow-reactor employing a mixed hydrogen-liquid flow stream for the efficient reduction of imines to amines.
Imines have been reduced to amines in high yield, and with excellent chemoselectivity, by catalytic hydrogenation in a continuous flow-reactor, utilising an electrochemically-generated hydrogen source to produce a mixed hydrogen-liquid flow stream.
Saaby
Steen
S
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UKCB2 1EW.
Knudsen
Kristian Rahbek
KR
Ladlow
Mark
M
Ley
Steven V
SV
D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000295:instrumentation / Q000379:methods; D006859:Hydrogen / Q000737:chemistry*; D006865:Hydrogenation; D007097:Imines / Q000737:chemistry*; D010084:Oxidation-Reduction
D000588:Amines; D007097:Imines; D006859:Hydrogen