[Features of operated nerve regeneration under decompensated form of diabetes].
Work is devoted to a problem of the influence of diabetes on nervous system function, in particular, the regeneration of peripheral nerves. Chronic experiment were carried out on 8 mini-pigs (weight 35-40 kg) in two stages. Absolute insulin insufficiency was formed by total pancreatomy (the first stage); on the same day the sciatic nerve of an animal was severed 5-6 sm above its branching and sewed by perineural seam (the second stage). 60 days after neurorrhaphy a seam zone with the adjacent tissues was dissected for the investigation of morphological macro- and microscopic features of proximal and distal stump in the operated sciatic nerve, regenerative neuroma, micro-circulating channel of a nerve, a connecting tissue of neural anastomosis and a nerve trunk as well as a level of synaptogenesis and a condition of separate muscles innervated by the operated nerve. The blood level of glucose and other biochemical parameters were assessed every three days. Macro- and microscopic examination testifies that the restoration of the operated nerve by sewing together of its ends under the decompensated diabetes, is considerably attenuated and is practically impossible during the late stages.
Honcharuk
O O
OO
A. P. Romodanov Institute Neurosurgery AMS of Ukraine, Kyiv.
D000818:Animals; D003714:Denervation; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology* / Q000601:surgery; D009416:Nerve Regeneration / Q000502:physiology*; D010180:Pancreatectomy; D012584:Sciatic Nerve / Q000502:physiology / Q000601:surgery*; D013552:Swine; D013556:Swine, Miniature