title: Phylogenetic heterogeneity of new HTLV type 1 isolates from southern India in subgroup A.
abstract: Seven isolates of human T cell leukemia virus type 1 (HTLV-1) were taken in southern India and phylogenetically analyzed to gain new insights into the origin and dissemination of HTLV-1 in the subcontinent. The new Indian HTLV-1s were found to be members of subgroup A (Transcontinental subgroup) of the Cosmopolitan group. They formed three different clusters (South African/Caribbean, Middle Eastern, and East Asian clusters). These results demonstrate that Indian HTLV-1s are genetically heterogeneous and include the most divergent strain of subgroup A. On the basis of these results, we speculate that subgroup A HTLV- 1s may have been present for thousands of years in India.
authors.affiliation: Laboratory of Primate Model, Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan.
authors.forename: Sadayuki
authors.initials: S
authors.lastname: Ohkura
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yamashita
authors.forename: Takafumi
authors.initials: T
authors.lastname: Ishida
authors.forename: Palla-George
authors.initials: PG
authors.lastname: Babu
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Koyanagi
authors.forename: Naoki
authors.initials: N
authors.lastname: Yamamoto
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Miura
authors.forename: Masanori
authors.initials: M
authors.lastname: Hayami
mesh_terms: D000328:Adult; D002648:Child; D004279:DNA, Viral / Q000737:chemistry; D005260:Female; D015490:HTLV-I Infections / Q000821:virology*; D015368:Human T-lymphotropic virus 1 / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010802:Phylogeny; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA; D020079:Terminal Repeat Sequences / Q000235:genetics
chemical_list: D004279:DNA, Viral