title: A gamut of loops: meandering DNA.
abstract: Nucleoprotein complexes comprising short DNA loops (150 base pairs or less) are involved in a wide variety of DNA transactions (e.g. transcription regulation, replication and recombination) in both prokaryotes and eukaryotes, and also can be useful in designing nanostructures. In these higher-order nucleoprotein complexes, proteins bound to spatially separated sites on a DNA interact with each other by looping out the relatively stiff intervening DNA. Recent technological developments have enabled determination of DNA trajectories in a few DNA-loop-containing regulatory complexes. Results show that, in a given system, a specific DNA trajectory is preferred over others.
authors.affiliation: Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 USA.
authors.forename: Szabolcs
authors.initials: S
authors.lastname: Semsey
authors.forename: Konstantin
authors.initials: K
authors.lastname: Virnik
authors.forename: Sankar
authors.initials: S
authors.lastname: Adhya
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism; D001665:Binding Sites; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000378:metabolism; D056968:Lac Repressors; D009690:Nucleic Acid Conformation; D009698:Nucleoproteins / Q000378:metabolism*; D020598:Proto-Oncogene Proteins c-myb / Q000235:genetics / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; D056968:Lac Repressors; D009698:Nucleoproteins; D020598:Proto-Oncogene Proteins c-myb; D012097:Repressor Proteins; C116822:hns protein, E coli; D004247:DNA