title: Longitudinal study of dogs living in an area of Spain highly endemic for leishmaniasis by serologic analysis and the leishmanin skin test.
abstract: The literature contains few longitudinal studies that have assessed areas endemic for canine leishmaniasis and over the same time interval Leishmania-specific cellular and humoral immunity in healthy dogs. Fourteen dogs, three mixed breed and 11 Ibizian hounds, living in an area of Spain that was highly endemic for leishmaniasis were followed-up over a three-year period by serologic analysis and the leishmanin skin test (LST). All but one of these dogs remained clinically healthy during the study period. Seroconversion was observed in four dogs. The three mixed breed dogs had a negative reaction in the LST in the first and third years. The general trend in the Ibizian hounds was an increase in the diameter of the LST reaction at both the 48- and 72-hour readings in the third year. This study demonstrates that in addition to an increase in Leishmania-specific humoral immune response in Ibizian hounds, a parallel increase in cellular immune response was observed.
authors.affiliation: Departament de Farmacologia, Terapèutica i Toxicologia, i Departament de Medicina i Cirurgia Animal, Facultat de Veterinaria, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain.
authors.forename: Laia
authors.initials: L
authors.lastname: Solano-Gallego
authors.forename: Joan
authors.initials: J
authors.lastname: Llull
authors.forename: Antonio
authors.initials: A
authors.lastname: Ramis
authors.forename: Hugo
authors.initials: H
authors.lastname: Fernández-Bellon
authors.forename: Alhelí
authors.initials: A
authors.lastname: Rodríguez
authors.forename: Lluís
authors.initials: L
authors.lastname: Ferrer
authors.forename: Jordi
authors.initials: J
authors.lastname: Alberola
mesh_terms: D000818:Animals; D000953:Antigens, Protozoan / Q000032:analysis*; D004283:Dog Diseases / Q000453:epidemiology*; D004285:Dogs; D005260:Female; D007896:Leishmaniasis / Q000453:epidemiology / Q000662:veterinary*; D008137:Longitudinal Studies; D008297:Male; D012882:Skin Tests; D013030:Spain / Q000453:epidemiology
chemical_list: D000953:Antigens, Protozoan; C032127:leishmanin