Tag-team SUMO wrestling.
Structural and kinetic studies of a SUMORanGAP1-Ubc9-Nup358/RanBP2 complex (Reverter and Lima, 2005) provide the first high-resolution view of SUMO recognition by a SUMO binding motif and also reveal a novel mechanism for E3 ubiquitin-like protein ligases, with the Nup358/RanBP2 E3 teaming up with both SUMO and the E2 (Ubc9) to stimulate tagging.
Duda
David M
DM
Department of Structural Biology, St. Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA.
Schulman
Brenda A
BA
D018832:Molecular Chaperones; D046912:Multiprotein Complexes / Q000737:chemistry / Q000378:metabolism*; D028861:Nuclear Pore Complex Proteins; D011487:Protein Conformation; D025842:SUMO-1 Protein / Q000737:chemistry / Q000378:metabolism*; D025801:Ubiquitin / Q000737:chemistry / Q000378:metabolism*; D044763:Ubiquitin-Conjugating Enzymes
D018832:Molecular Chaperones; D046912:Multiprotein Complexes; D028861:Nuclear Pore Complex Proteins; D025842:SUMO-1 Protein; D025801:Ubiquitin; C094493:ran-binding protein 2; D044763:Ubiquitin-Conjugating Enzymes