Malignant myoepithelioma arising from recurrent pleomorphic adenoma of the soft palate.
Malignant myoepithelioma is a rare salivary gland neoplasm that can arise either de novo or within a pre-existing pleomorphic adenoma. We report a case of malignant myoepithelioma arising from a pleomorphic adenoma of the soft palate. A 70-year-old woman presented in our department with a very large tumor of the soft palate. The patient had a history of a pleomorphic adenoma at the same location that was surgically removed 2 years ago. A second operation, with intraoral excision of the tumor was performed. Histological examination of the recurrence revealed a malignant spindle cell neoplasm with an infiltrative growth pattern and a high mitotic rate. Immunohistochemical investigation confirmed the diagnosis of a low-grade carcinoma of myoepithelial origin with free surgical margins. The patient remains free of disease for more than twelve months after the end of treatment.
Karatzanis
Alexandros D
AD
Department of Otorhinolaryngology, University of Crete School of Medicine, Heraklion, Crete, Greece.
Drivas
Emmanouil I
EI
Giannikaki
Elpida S
ES
Lachanas
Vasilios A
VA
Hatziioannou
John K
JK
Velegrakis
George A
GA
D008949:Adenoma, Pleomorphic / Q000473:pathology* / Q000601:surgery; D000368:Aged; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009208:Myoepithelioma / Q000473:pathology* / Q000601:surgery; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010160:Palate, Soft / Q000473:pathology* / Q000601:surgery; D010610:Pharyngeal Neoplasms / Q000473:pathology* / Q000601:surgery; D012468:Salivary Gland Neoplasms / Q000473:pathology* / Q000601:surgery