Adhesion formation and interanimal variability in a laparoscopic mouse model varies with strains.
Adhesion formation after laparoscopic surgery was evaluated in mice of different strains. More adhesions were observed in Swiss, NMRI, and BALB/c mice, with less interanimal variability in BALB/c mice. These data point to genetics effects on adhesion formation, which open new insights in its pathogenesis and indicate the importance of a careful strain selection for animal studies.
Molinas
Carlos Roger
CR
Laboratory of Experimental Gynecology, Department of Obstetrics and Gynecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium. Roger.Molinas@uz.kuleuven.ac.be
Binda
Maria Mercedes
MM
Campo
Rudi
R
Koninckx
Philippe Robert
PR
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D010535:Laparoscopy / Q000009:adverse effects* / Q000706:statistics & numerical data; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D023421:Models, Animal; D011183:Postoperative Complications; D013045:Species Specificity; D000267:Tissue Adhesions / Q000235:genetics* / Q000503:physiopathology