title: Activated protein C for the treatment of fulminant meningococcal septicaemia.
abstract: We report two cases of meningococcal septic shock with multiple organ failure treated with prompt administration of activated protein C. This was associated with a rapid clinical improvement and early cessation of organ support. Both patients survived to hospital discharge with no long-term sequelae.
authors.affiliation: Intensive Care Unit, Westmead Hospital, Westmead, New South Wales.
authors.forename: G L
authors.initials: GL
authors.lastname: Thomas
authors.forename: T
authors.initials: T
authors.lastname: Wigmore
authors.forename: P
authors.initials: P
authors.lastname: Clark
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008589:Meningococcal Infections / Q000150:complications / Q000188:drug therapy*; D009102:Multiple Organ Failure / Q000209:etiology*; D011486:Protein C / Q000627:therapeutic use*; D012772:Shock, Septic / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000925:Anticoagulants; D011486:Protein C