title: N-Substituted acridone alkaloids from Toddaliopsis bremekampii (Rutaceae: Toddalioideae) of south-central Africa.
abstract: Toddaliopsins A-D, four novel 1,2,3-trioxygenated acridone alkaloids, have been isolated from the leaves of Toddaliopsis bremekampii. Toddaliopsins B-D are the first reported acridone alkaloids with substituted N-methyl groups, in the light of which the chemotaxonomic relationship of Toddaliopsis and Vepris is discussed. Toddaliopsin C possesses moderate anti-inflammatory activity, which may be related to the hydroxy group present at C-1.
authors.affiliation: School of Chemistry, University of KwaZulu-Natal, Howard College Campus, Durban 4041, South Africa.
authors.forename: Dashnie
authors.initials: D
authors.lastname: Naidoo
authors.forename: Philip H
authors.initials: PH
authors.lastname: Coombes
authors.forename: Dulcie A
authors.initials: DA
authors.lastname: Mulholland
authors.forename: Neil R
authors.initials: NR
authors.lastname: Crouch
authors.forename: Albert J J
authors.initials: AJ
authors.lastname: van den Bergh
mesh_terms: D000166:Acridines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D054831:Acridones; D000349:Africa; D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008163:Luminescent Measurements; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects; D018515:Plant Leaves / Q000737:chemistry; D027821:Rutaceae / Q000737:chemistry*
chemical_list: D000166:Acridines; D054831:Acridones; D000470:Alkaloids; C041300:acridone