title: BCG modulation of anaphylactic antibody response, airway inflammation and lung hyperreactivity in genetically selected mouse strains (Selection IV-A).
abstract: The effect of Bacillus Calmette-Guérin (BCG) treatment in allergic pulmonary reaction was studied in mice genetically selected accordingly to a High (H-IVA) or Low (L-IVA) antibody responsiveness. Mice were immunized with ovalbumin (OVA) or OVA plus BCG. Two days after nasal antigenic challenge, seric IgE and IgG1 anti-OVA, eosinophils in pulmonary tissue, inflammatory cells in bronchoalveolar lavage and the compliance and conductance of respiratory system were evaluated. H-IVA mice were found more susceptible than L-IVA, and BCG was able to inhibit simultaneously the production of IgE, the bronchopulmonary inflammation and bronchial hyperresponsiveness in these genetically selected mice.
authors.affiliation: Division of Clinical Immunology and Allergy, Heart Institute (InCor), Division of General Internal Medicine, Department of Medicine, University São Paulo, Av. Dr. Arnaldo, 455, Cerqueira César, 01246-903, São Paulo, Brazil. myrtb@uol.com.br
authors.forename: Myrthes Toledo
authors.initials: MT
authors.lastname: Barros
authors.forename: Milena Marques Pagliarelli
authors.initials: MM
authors.lastname: Acencio
authors.forename: Maria Lúcia Bueno
authors.initials: ML
authors.lastname: Garcia
authors.forename: Maria Fernanda
authors.initials: MF
authors.lastname: Macedo Soares
authors.forename: Olga M
authors.initials: OM
authors.lastname: Ibañez
authors.forename: Milton Arruda
authors.initials: MA
authors.lastname: Martins
authors.forename: Orlando Garcia
authors.initials: OG
authors.lastname: Ribeiro
authors.forename: Jorge
authors.initials: J
authors.lastname: Kalil
authors.forename: Adenir
authors.initials: A
authors.lastname: Perini
mesh_terms: D000818:Animals; D001500:BCG Vaccine / Q000276:immunology*; D016535:Bronchial Hyperreactivity / Q000517:prevention & control*; D004797:Enzyme-Linked Immunosorbent Assay; D006967:Hypersensitivity / Q000517:prevention & control*; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007249:Inflammation / Q000517:prevention & control*; D007371:Interferon-gamma / Q000096:biosynthesis; D007962:Leukocytes / Q000502:physiology; D008168:Lung / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis / Q000276:immunology*; D051381:Rats; D011920:Rats, Inbred WF
chemical_list: D001500:BCG Vaccine; D007074:Immunoglobulin G; D007073:Immunoglobulin E; D007371:Interferon-gamma; D010047:Ovalbumin