Comparison of 0.5-M Gd-DTPA with 1.0-M gadobutrol for magnetic resonance angiography of the supplying arteries of the spinal cord in thoracoabdominal aortic aneurysm patients.
OBJECTIVE
To prospectively compare 0.5-M gadopentetate dimeglumine (Gd-DTPA) with 1.0-M gadobutrol for contrast-enhanced magnetic resonance angiography (CE-MRA) of the blood supplying arteries of the spinal cord in patients referred for open surgical repair of a thoracoabdominal aortic aneurysm (TAAA).


METHODS
A total of 11 patients with a TAAA underwent two three-dimensional CE-MRA exams of the aorta, segmental arteries (SAs), artery of Adamkiewicz (AKA), and anterior spinal artery (ASA). Imaging was performed on two separate occasions using Gd-DTPA and gadobutrol as contrast agents at 0.3 mmol/kg. Images were evaluated by measuring signal-to-noise (SNR) and contrast-to-noise (CNR) ratios and were judged for different image quality criteria by two blinded observers.


RESULTS
In all patients both CE-MRA exams were of sufficient image quality to detect the AKA and ASA. No significant differences in SNR and CNR were observed between the two contrast agents. According to the observers, no significant differences in subjective image quality were found.


CONCLUSIONS
Using both contrast agents it was possible to visualize the ultrasmall spinal cord arteries in all cases. The use of the 1.0-M contrast agent did not improve image quality of CE-MRA images of the blood supplying arteries of the spinal cord compared to the 0.5-M contrast agent.
Nijenhuis
Robbert J
RJ
Department of Radiology, Cardiovascular Research Institute Maastricht, Maastricht University Hospital, Maastricht, The Netherlands. Nijenhuis@rad.unimaas.nl
Gerretsen
Suzanne
S
Leiner
Tim
T
Jacobs
Michael J
MJ
van Engelshoven
Jos M A
JM
Backes
Walter H
WH
D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000175:diagnosis* / Q000601:surgery; D017545:Aortic Aneurysm, Thoracic / Q000175:diagnosis* / Q000601:surgery; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D009942:Organometallic Compounds; D011446:Prospective Studies; D013116:Spinal Cord / Q000098:blood supply*
D003287:Contrast Media; D009942:Organometallic Compounds; C090600:gadobutrol; D019786:Gadolinium DTPA