Mobile classification in microarray experiments.
In a homogeneous group of samples, there are genes whose expression variations can be attributed to factors other than experimental errors. These factors can include natural biological oscillations or metabolic processes. These genes are rarely classified as 'interesting' based on their variability profile. However, their dynamic behaviour can tease out important clues about naturally occurring biological processes in the organism under study and can be used for group classification. Dynamical discriminate function analysis was developed on the concept that stable classification parameters (roots) can be derived from highly variable gene-expression data. Stability of these combinations implies a strongly compensatory relationship that may divulge functional interconnections.
Dozmorov
I M
IM
Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA. igor-dozmorov@omrf.ouhsc.edu
Centola
M
M
Knowlton
N
N
Tang
Y
Y
D003093:Colitis, Ulcerative / Q000235:genetics / Q000276:immunology; D022801:Complementarity Determining Regions; D003424:Crohn Disease / Q000235:genetics / Q000276:immunology; D016002:Discriminant Analysis; D020869:Gene Expression Profiling / Q000145:classification; D049673:History, 20th Century; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000145:classification / Q000378:metabolism*; D009504:Neutrophils / Q000145:classification / Q000378:metabolism*; D020411:Oligonucleotide Array Sequence Analysis / Q000145:classification
D022801:Complementarity Determining Regions