Nitric oxide synthase activity and endogenous inhibitors in rats recovered from allergic encephalomyelitis.
We have previously reported that in comparison with normal rats, the presence of experimental allergic encephalomyelitis (EAE) leads to decreased endogenous inhibitory activity (EIA) of Ca2+-dependent nitric oxide synthase (NOS) in both brain and serum, and increased expression of protein 3-nitrotyrosine (NT) in brain. In this work we show that animals recovered from the clinical signs of EAE are not different from controls in terms of either brain NOS activity, EIA of NOS, or NT expression. These results suggest that parallel to the reversal of the disease symptoms, a normalization of the production of nitric oxide and related species occurs.
Teixeira
S A
SA
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP 05508-900, Brasil.
Varriano
A A
AA
Dias
A A
AA
Martins Porto
R
R
Muscará
M N
MN
D000818:Animals; D001921:Brain / Q000201:enzymology*; D056445:Cytoplasmic Dyneins; D004398:Dyneins / Q000378:metabolism; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000097:blood / Q000201:enzymology*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D052250:Nitric Oxide Synthase Type III / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051381:Rats; D011917:Rats, Inbred Lew
D009569:Nitric Oxide; D052250:Nitric Oxide Synthase Type III; C486069:Dynll1 protein, rat; D056445:Cytoplasmic Dyneins; D004398:Dyneins