Infection, autoimmunity, and glycolipids: T cells detect microbes through self-recognition.
De Libero et al. (2005) demonstrate in this issue of Immunity that bacterial infection leads to increased synthesis of autologous glycolipids that are recognized by CD1-restricted human T cells, indicating that recognition of inducible self-glycolipids could be a mechanism for microbial detection. This mechanism also may provide a connection between infection and autoimmunity.
Kronenberg
Mitchell
M
La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA.
Kinjo
Yuki
Y
D018949:Antigens, CD1 / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D015551:Autoimmunity / Q000276:immunology*; D001424:Bacterial Infections / Q000276:immunology*; D006017:Glycolipids / Q000276:immunology*; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology*
D018949:Antigens, CD1; D001324:Autoantigens; D006017:Glycolipids