Clinical evaluation of serum p53 antibodies in patients with upper urinary tract tumors.
OBJECTIVE
We retrospectively assessed the clinical significance of anti-p53 antibody (S-p53Ab) status in the serum of patients with upper urinary tract tumors.


METHODS
Enzyme-linked immunosorbent assay was used to analyze S-p53Abs in 63 upper urinary tract tumors. Its incidence and clinical or pathological background were analyzed in comparison with 80 bladder tumors.


RESULTS
The prevalence of S-p53Abs in patients with upper urinary tract tumors was higher than that in patients with bladder tumors (27.0% vs 17.5%). Especially, 34.8% of patients showed positive S-p53Abs in invasive upper urinary tract tumors (pT1 or more). In upper urinary tract tumors the prevalence of S-p53Abs significantly correlated with higher grade (p <0.01), higher stage (p = 0.02), positive lymph nodes (p = 0.03) and p53 nuclear accumulation (p <0.01). However, disease specific survival after nephroureterectomy did not differ between patients with negative and positive S-p53Abs.


CONCLUSIONS
Our data suggest the possibility of the clinical application of S-p53Abs, especially for the detection of high grade or high stage tumors in the upper urinary tract. However, the usefulness of S-p53Abs as prognostic marker seems to be extremely limited in patients with urothelial tumors.
Watanabe
Jun
J
Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Nishiyama
Hiroyuki
H
Kawanishi
Hiroaki
H
Ito
Masaaki
M
Kamoto
Toshiyuki
T
Ogawa
Osamu
O
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies / Q000276:immunology*; D002295:Carcinoma, Transitional Cell / Q000097:blood*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016159:Tumor Suppressor Protein p53 / Q000276:immunology*; D014516:Ureteral Neoplasms / Q000097:blood*; D001749:Urinary Bladder Neoplasms / Q000097:blood*
D000906:Antibodies; D016159:Tumor Suppressor Protein p53