title: Anti-MuSK myasthenia gravis presenting with purely ocular findings.
abstract: BACKGROUND
  Antibodies to a muscle-specific receptor tyrosine kinase (MuSK) have been found in approximately 40% of patients with generalized myasthenia gravis who are seronegative for the antiacetylcholine receptor antibody. Many of the patients with anti-MuSK antibodies have prominent oculobulbar symptoms or weakness of the neck and respiratory muscles, but patients with ocular myasthenia have not been described.
  
  
  OBJECTIVE
  To report a case of ocular myasthenia due to anti-MuSK antibodies.
  
  
  METHODS
  A young woman with ocular myasthenia and antibodies to MuSK.
  
  
  RESULTS
  Anti-MuSK antibody was detected by radioimmunoassay using highly purified MuSK recombinant antigen.
  
  
  CONCLUSIONS
  Ocular myasthenia gravis is a presentation of the anti-MuSK antibody syndrome.
authors.affiliation: Department of Neurology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. jcaress@wfubmc.edu
authors.forename: James B
authors.initials: JB
authors.lastname: Caress
authors.forename: Christopher H
authors.initials: CH
authors.lastname: Hunt
authors.forename: Sat Dev
authors.initials: SD
authors.lastname: Batish
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000097:blood*; D001763:Blepharoptosis / Q000175:diagnosis* / Q000276:immunology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D009157:Myasthenia Gravis / Q000175:diagnosis* / Q000276:immunology*; D020794:Receptor Protein-Tyrosine Kinases / Q000276:immunology*; D011950:Receptors, Cholinergic / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D011950:Receptors, Cholinergic; C095714:MUSK protein, human; D020794:Receptor Protein-Tyrosine Kinases