Muco-cutaneous candidiasis in two pigs with postweaning multisystemic wasting syndrome.
In two distinct commercial swine herds, poor weight gain and an increased number of animals showing wasting were observed among nursery and growing pigs. Cases of postweaning multisystemic wasting syndrome (PMWS) and infection with Haemophilus parasuis had been previously diagnosed in these herds. One growing wasted pig from each herd was necropsied and showed enlarged lymph nodes. Pseudomembranous material adhered to the dorsum of the tongue, soft and hard palate in case 1, and in case 2, fibrinous material was seen as whitish plaques on the oesophageal surface with hyperkeratosis of the non-glandular stomach. The main histological lesions in both cases were found in lymphoid tissues with a multifocal accentuated lymphohistiocytic infiltrate, areas of lymphoid depletion and intracytoplasmic inclusions in histiocytic cells in lymph nodes and Payer's patches. Focally, extensive ulceration was found in the stratified pavement epithelium of the tongue with necrosis and necrosuppurative infiltrate in case 1; in case 2, there was ulceration in the stomach with lymphohistiocytic infiltrate in the submucosa and ulceration in the mucosa of the oesophagus associated with yeast cells and pseudo-hyphae. Candida albicans was isolated from the oral cavity lesions. Immunohistochemistry of the lymph nodes was positive for porcine circovirus 2 (PCV2). The association between PMWS and mucocutaneous candidiasis reported here supports the potential immunosuppressive state of PMWS infected pigs.
Zlotowski
Priscila
P
Laboratory of Veterinary Pathology, College of Veterinary Medicine, Federal University of Rio Grande do Sul (UFRGS), Av. Bento Gonçalves 9090, 91540-000 Porto Alegre, RS, Brazil.
Rozza
Daniela B
DB
Pescador
Caroline A
CA
Barcellos
David E
DE
Ferreiro
Laerte
L
Sanches
Edna M C
EM
Driemeier
David
D
D000818:Animals; D002178:Candidiasis, Chronic Mucocutaneous / Q000209:etiology / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D018173:Circoviridae Infections / Q000150:complications / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D017925:Circovirus; D004198:Disease Susceptibility / Q000662:veterinary; D016867:Immunocompromised Host; D007150:Immunohistochemistry / Q000662:veterinary; D013552:Swine; D013553:Swine Diseases / Q000276:immunology* / Q000382:microbiology / Q000473:pathology / Q000821:virology; D019282:Wasting Syndrome / Q000150:complications / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D014886:Weaning