title: Expecting the unexpected: modeling of neuromodulation.
abstract: An important aspect of decision-making is the need to make interpretations and predictions in the face of uncertain information. In this issue of Neuron, Yu and Dayan describe a model of the role of acetylcholine and norepinephrine in balancing top-down expectation and bottom-up sensory input in guiding behavior. The model builds from data on physiological effects of modulators regulating the balance of cortical feedback and thalamic input.
authors.affiliation: Department of Psychology, Center for Memory and Brain and Program in Neuroscience, Boston University, Massachusetts 02215, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Hasselmo
mesh_terms: D000109:Acetylcholine; D000818:Animals; D005246:Feedback / Q000502:physiology*; D006801:Humans; D007257:Information Theory; D008959:Models, Neurological; D009638:Norepinephrine; D013788:Thalamus / Q000502:physiology
chemical_list: D000109:Acetylcholine; D009638:Norepinephrine