title: [Antiviral activity of oral ultralow doses of antibodies to gamma-interferon: experimental study of influenza infection in mice].
abstract: Course intragastric administration of ultralow doses of human gamma-interferon antibodies (ULD anti-IFN-gamma) to intact mice resulted in an increase of endogenous IFN-gamma production by the animal lymphocytes. Oral prophylactic administration of ULD anti-IFN-gamma significantly lowered the influenza virus concentration in the animal lungs at the initial stage of the aerogenous infection: in 2 (p = 0.05) and 3 (p = 0.07) days after the contamination. The therapeutic antiviral effect of ULD anti-IFN-gamma in mice with influenza was evident from a significant decrease of the influenza virus concentration in the lungs of the animals on the 4th (p = 0.05) and 5th (p = 0.07) days after the contamination. The antiviral effect of ULD anti-IFN-gamma after the prophylactic and therapeutic use is likely provided by induction of endogenous IFN-gamma.
authors.forename: A N
authors.initials: AN
authors.lastname: Sergeev
authors.forename: O V
authors.initials: OV
authors.lastname: P'iankov
authors.forename: L N
authors.initials: LN
authors.lastname: Shishkina
authors.forename: L G
authors.initials: LG
authors.lastname: Duben'
authors.forename: V A
authors.initials: VA
authors.lastname: Petrishchenko
authors.forename: V A
authors.initials: VA
authors.lastname: Zhukov
authors.forename: O G
authors.initials: OG
authors.lastname: P'iankova
authors.forename: L I
authors.initials: LI
authors.lastname: Sviatchenko
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Sherstoboev
authors.forename: T V
authors.initials: TV
authors.lastname: Karimova
authors.forename: A V
authors.initials: AV
authors.lastname: Martiushev-Poklad
authors.forename: S A
authors.initials: SA
authors.lastname: Sergeeva
authors.forename: O I
authors.initials: OI
authors.lastname: Epshteĭn
authors.forename: A G
authors.initials: AG
authors.lastname: Glotov
authors.forename: T I
authors.initials: TI
authors.lastname: Glotova
mesh_terms: D000818:Animals; D000906:Antibodies / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D009980:Influenza A virus / Q000302:isolation & purification; D007371:Interferon-gamma / Q000096:biosynthesis / Q000276:immunology*; D008168:Lung / Q000276:immunology / Q000821:virology; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000517:prevention & control* / Q000628:therapy / Q000821:virology; D013154:Spleen / Q000276:immunology; D013997:Time Factors
chemical_list: D000906:Antibodies; D000998:Antiviral Agents; D007371:Interferon-gamma