title: The emergence of west nile virus during a large outbreak in Illinois in 2002.
abstract: In 2002, the world's largest outbreak of neuroinvasive West Nile virus (WNV) disease occurred. Illinois reported 21% of the total cases in the United States, the most among all states. The epidemiology of WNV in Illinois in 2002 was examined to determine factors associated with severe disease and death. A total of 884 cases were identified and there were 66 deaths. The overall attack rate of WNV infection was 7.1 per 100,000 population and this increased with age. The median ages of patients and patients who died were 56 and 78 years, respectively. Among patients who died, 91% were diagnosed with encephalitis and the case-fatality rate for patients with encephalitis was 18.6%. Patients more than 50 years old had a significantly higher risk of being reported with encephalitis (relative risk [RR] = 3.3, 95% confidence interval [CI] = 2.6-4.3%) and death (RR = 22.3, 95% CI = 5.5-90.4%). Clinicians evaluating elderly patients with WNV infection should assess patients closely for progression of disease.
authors.affiliation: Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. ghuhn@idph.state.il.us
authors.forename: Gregory D
authors.initials: GD
authors.lastname: Huhn
authors.forename: Connie
authors.initials: C
authors.lastname: Austin
authors.forename: Carl
authors.initials: C
authors.lastname: Langkop
authors.forename: Kate
authors.initials: K
authors.lastname: Kelly
authors.forename: Roland
authors.initials: R
authors.lastname: Lucht
authors.forename: Richard
authors.initials: R
authors.lastname: Lampman
authors.forename: Robert
authors.initials: R
authors.lastname: Novak
authors.forename: Linn
authors.initials: L
authors.lastname: Haramis
authors.forename: Rosemary
authors.initials: R
authors.lastname: Boker
authors.forename: Stephanie
authors.initials: S
authors.lastname: Smith
authors.forename: Maria
authors.initials: M
authors.lastname: Chudoba
authors.forename: Susan
authors.initials: S
authors.lastname: Gerber
authors.forename: Craig
authors.initials: C
authors.lastname: Conover
authors.forename: Mark S
authors.initials: MS
authors.lastname: Dworkin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001717:Birds / Q000821:virology; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007087:Illinois / Q000453:epidemiology; D007223:Infant; D008875:Middle Aged; D011159:Population Surveillance; D014901:West Nile Fever / Q000453:epidemiology*; D014902:West Nile virus / Q000302:isolation & purification