title: Rhodanine derivatives as inhibitors of JSP-1.
abstract: Dual-specificity phosphatases (DSPs) are a subclass within the protein tyrosine phosphatase family (PTPs). A series of rhodanine-based inhibitors was synthesized and shown to be novel, potent, and selective inhibitors against the DSP family member JNK-stimulating phosphatase-1 (JSP-1). Compounds of this class may be useful for the treatment of inflammatory and proliferative disorders.
authors.affiliation: Ceptyr Inc., 3830 Monte Villa Parkway, Suite 200, Bothell, WA 98021, USA. ncutshall@ceptyr.com
authors.forename: Neil S
authors.initials: NS
authors.lastname: Cutshall
authors.forename: Christine
authors.initials: C
authors.lastname: O'Day
authors.forename: Marina
authors.initials: M
authors.lastname: Prezhdo
mesh_terms: D015195:Drug Design; D054637:Dual-Specificity Phosphatases; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D054639:Mitogen-Activated Protein Kinase Phosphatases; D015394:Molecular Structure; D054645:Protein Phosphatase 1; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors*; D012236:Rhodanine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D012236:Rhodanine; D054639:Mitogen-Activated Protein Kinase Phosphatases; D054645:Protein Phosphatase 1; C442824:DUSP22 protein, human; D054637:Dual-Specificity Phosphatases; D017027:Protein Tyrosine Phosphatases