title: Inhibin A and activin A may be used to predict pregnancy outcome in women with recurrent miscarriage.
abstract: OBJECTIVE
  To look at the role of inhibin and activin in predicting pregnancy outcome in patients with history of recurrent miscarriage.
  
  
  METHODS
  Observational clinical study.
  
  
  METHODS
  Recurrent miscarriage clinic of a tertiary care teaching hospital.
  
  
  METHODS
  Patients with history of recurrent miscarriage.
  
  
  METHODS
  Serial serum inhibin A and activin A concentrations were measured in weeks 5 though 8 of pregnancy.
  
  
  METHODS
  Serum concentrations of inhibin A and activin A levels.
  
  
  RESULTS
  Mean inhibin A concentration at 5 to 6 weeks for women who miscarried and those who had live births was 33 and 51 pg/mL, respectively; activin A at same gestation for the two groups was 534 and 643 pg/mL, respectively. After 2 weeks, mean inhibin A concentration for women who miscarried and those who had live births was 66 and 145 pg/mL, respectively, and activin A was 747 and 1,123 pg/mL, respectively.
  
  
  CONCLUSIONS
  It is possible that inhibin A and activin A may be used as markers to predict pregnancies that are likely to miscarry.
authors.affiliation: Academic Unit of Reproductive and Developmental Medicine, University of Sheffield, Jessop Wing, Sheffield, United Kingdom. a.prakash@sheffield.ac.uk
authors.forename: Alka
authors.initials: A
authors.lastname: Prakash
authors.forename: Susan
authors.initials: S
authors.lastname: Laird
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Tuckerman
authors.forename: Tin C
authors.initials: TC
authors.lastname: Li
authors.forename: William L
authors.initials: WL
authors.lastname: Ledger
mesh_terms: D000026:Abortion, Habitual / Q000097:blood* / Q000453:epidemiology*; D028341:Activins / Q000097:blood*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D028322:Inhibin-beta Subunits / Q000097:blood*; D007265:Inhibins / Q000097:blood*; D050498:Live Birth / Q000453:epidemiology*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; C422405:activin A; C422362:inhibin A; D028341:Activins; D007265:Inhibins; D028322:Inhibin-beta Subunits