Lymphomatoid papulosis in a patient with atopic eczema on long-term ciclosporin therapy.
We report a 36-year-old man with atopic eczema who developed lymphomatoid papulosis while taking ciclosporin. Latent membrane protein 1 and in situ hybridization for Epstein-Barr virus were negative. There are only two reports in the literature of patients taking ciclosporin to control atopic eczema who developed primary cutaneous CD30+ T-cell lymphoproliferative disorders. The development of T-cell lymphoproliferative disorders including lymphomas is well described in patients with solid organ transplants who are taking ciclosporin. Also, it has been noted in patients taking ciclosporin for rheumatological conditions or psoriasis.
Laube
S
S
Department of Dermatology, University Hospital of North Staffordshire, Stoke-on-Trent ST4 7PA, UK. slaube@doctors.org.uk
Stephens
M
M
Smith
A G
AG
Whittaker
S J
SJ
Tan
B B
BB
D000328:Adult; D016572:Cyclosporine / Q000009:adverse effects* / Q000627:therapeutic use; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D017731:Lymphomatoid Papulosis / Q000139:chemically induced*; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D008727:Methotrexate