title: Integrated computed tomography-positron emission tomography in patients with potentially resectable malignant pleural mesothelioma: Staging implications.
abstract: BACKGROUND
  Integrated computed tomography-positron emission tomography imaging with coregistration of anatomic and functional imaging data may improve the accuracy of malignant pleural mesothelioma staging. We evaluate the use of integrated computed tomography-positron emission tomography in patients with malignant pleural mesothelioma who are being considered for extrapleural pneumonectomy.
  
  
  METHODS
  Twenty-nine patients with malignant pleural mesothelioma who were judged to be candidates for extrapleural pneumonectomy after clinical and conventional radiologic evaluation underwent whole-body integrated computed tomography-positron emission tomography and pathologic staging. Two reviewers blinded to the results of clinical and pathologic staging retrospectively evaluated computed tomography, positron emission tomography, and coregistered computed tomography-positron emission tomography images. Staging was performed according to the International Mesothelioma Interest Group TNM staging system. Histopathology and/or results of further radiologic evaluation or follow-up served as the reference standard.
  
  
  RESULTS
  Integrated computed tomography-positron emission tomography provided additional information in 11 of 29 patients that precluded extrapleural pneumonectomy. The overall tumor stage was correctly classified in 21 of 29 patients. The tumor stage was correctly determined in 15 of 24 patients, 6 of whom had T4 (nonresectable) disease. The node stage was accurately determined in 6 of 17 patients. Extrathoracic metastases not identified by routine clinical and conventional radiologic evaluation were detected in 7 of 29 patients and were found to be diffuse (n = 2) or solitary (n = 5).
  
  
  CONCLUSIONS
  Integrated computed tomography-positron emission tomography increases the accuracy of malignant pleural mesothelioma staging and is important in determining the appropriate therapy in patients being considered for extrapleural pneumonectomy.
authors.affiliation: Departments of Diagnostic Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, Tex, USA. jerasmus@di.mdacc.tmc.edu
authors.forename: Jeremy J
authors.initials: JJ
authors.lastname: Erasmus
authors.forename: Mylene T
authors.initials: MT
authors.lastname: Truong
authors.forename: W Roy
authors.initials: WR
authors.lastname: Smythe
authors.forename: Reginald F
authors.initials: RF
authors.lastname: Munden
authors.forename: Edith M
authors.initials: EM
authors.lastname: Marom
authors.forename: David C
authors.initials: DC
authors.lastname: Rice
authors.forename: Ara A
authors.initials: AA
authors.lastname: Vaporciyan
authors.forename: Garrett L
authors.initials: GL
authors.lastname: Walsh
authors.forename: Bradley S
authors.initials: BS
authors.lastname: Sabloff
authors.forename: Lyle D
authors.initials: LD
authors.lastname: Broemeling
authors.forename: Craig W
authors.initials: CW
authors.lastname: Stevens
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Pisters
authors.forename: Donald A
authors.initials: DA
authors.lastname: Podoloff
authors.forename: Homer A
authors.initials: HA
authors.lastname: Macapinlac
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000175:diagnosis* / Q000601:surgery; D008875:Middle Aged; D009367:Neoplasm Staging; D010997:Pleural Neoplasms / Q000175:diagnosis* / Q000601:surgery; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed