title: Compound changes and tooth mineralization effects of glass ionomer cements containing bioactive glass (S53P4), an in vivo study.
abstract: In this study, modifications of glass ionomer cements (GICs) were made by adding bioactive glass (BAG) to GIC to obtain bioactive restorative materials. This study used SEM, EDS and visual analysis to examine the bioactivity and the ability of the study materials to mineralize dentin. Conventional cure and resin-modified light-curing GIC were used. The materials consisted of powder and liquid. Three experimental materials were made by mixing 10-30 wt% of BAG powder with GIC powders. Commercially available GIC without BAG were used as controls. Class III restorations were made in altogether 62 intact beagle dog teeth, and the operation was performed under general anesthesia. The restorations were followed clinically for 1, 3 or 6 weeks. Resin-modified GIC containing BAG showed uniform CaP surface formation on the restorations. Mineral depositions in the close vicinity of the restoration-dentin interface and in deeper parts of dentin tubules were also noticed in resin-modified GIC containing BAG particles. It can be concluded that resin-modified GIC containing BAG have good potential in clinical applications where enhanced mineralization is expected.
authors.affiliation: Department of Prosthetic Dentistry and Biomaterials Research, Institute of Dentistry, University of Turku, Lemminkäisenkatu 2, 20520 Turku, Finland. helena.yli-urpo@utu.fi
authors.forename: Helena
authors.initials: H
authors.lastname: Yli-Urpo
authors.forename: Matti
authors.initials: M
authors.lastname: Närhi
authors.forename: Timo
authors.initials: T
authors.lastname: Närhi
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001672:Biocompatible Materials; D017610:Calcium Compounds / Q000737:chemistry; D003188:Composite Resins; D019245:Compressive Strength; D001840:Dental Bonding; D003738:Dental Cements / Q000737:chemistry; D003799:Dental Stress Analysis; D003804:Dentin / Q000737:chemistry; D017220:Dentin-Bonding Agents / Q000737:chemistry; D004285:Dogs; D005459:Fluorides / Q000737:chemistry; D005898:Glass / Q000737:chemistry*; D005899:Glass Ionomer Cements / Q000737:chemistry*; D006244:Hardness; D006863:Hydrogen-Ion Concentration; D008027:Light; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010087:Oxides / Q000737:chemistry; D017553:Phosphorus Compounds / Q000378:metabolism; D011208:Powders; D019279:Resin Cements / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D013499:Surface Properties; D013997:Time Factors; D014070:Tooth
chemical_list: D001672:Biocompatible Materials; D017610:Calcium Compounds; D003188:Composite Resins; D003738:Dental Cements; D017220:Dentin-Bonding Agents; D005899:Glass Ionomer Cements; D010087:Oxides; D017553:Phosphorus Compounds; D011208:Powders; D019279:Resin Cements; C403922:bioactive glass S53P4; C012500:phosphorus pentoxide; D012822:Silicon Dioxide; C016538:lime; D005459:Fluorides