[Expressions of nuclear factor-kappaB and intercellular adhesion molecule-1 in endometriosis].
OBJECTIVE
To investigate the association of nuclear factor-kappaB (NF-kappaB) and intercellular adhesion molecule-1 (ICAM-1) with endometriosis.


METHODS
Immunohistochemistry was used to examine the NF-kappaB and VEGF protein expression in 35 specimens of normal endometrium, 48 eutopic endometrium of endometriosis and 76 ectopic endometrium, and the results were analyzed statistically.


RESULTS
The expressions of NF-kappaB and ICAM-1 were found mainly in the glandular epithelial cells of the three endometrium specimens, with the ectopic endometriotic tissues showing the highest and normal endometrium the lowest expressions (P<0.001). NF-kappaB and ICAM-1 expressions were positively correlated to normal, eutopic and ectopic endometrium (r=0.688, 0.773 and 0.777, respectively, P<0.01).


CONCLUSIONS
NF-kappaB and ICAM-1 may participate in the process of the pathogenesis in endometriosis.
Wang
Fang
F
Department of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. wangfang1973_8@hotmail.com
He
Yuan-li
YL
Peng
Dong-xian
DX
Liu
Mu-biao
MB
D004715:Endometriosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis* / Q000235:genetics; D016328:NF-kappa B / Q000096:biosynthesis* / Q000235:genetics; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis / Q000235:genetics
D016328:NF-kappa B; D042461:Vascular Endothelial Growth Factor A; D018799:Intercellular Adhesion Molecule-1