title: Strategies for targeting protein-protein interactions with synthetic agents.
abstract: The development of small-molecule modulators of protein-protein interactions is a formidable goal, albeit one that possesses significant potential for the discovery of novel therapeutics. Despite the daunting challenges, a variety of examples exists for the inhibition of two large protein partners with low-molecular-weight ligands. This review discusses the strategies for targeting protein-protein interactions and the state of the art in the rational design of molecules that mimic the structures and functions of their natural targets.
authors.affiliation: Yale University, New Haven, CT, USA.
authors.forename: Hang
authors.initials: H
authors.lastname: Yin
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Hamilton
mesh_terms: D000818:Animals; D030541:Databases, Genetic; D015195:Drug Design; D006801:Humans; D011485:Protein Binding / Q000187:drug effects; D011506:Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: D011506:Proteins