title: [The role of drug metabolizing enzymes in the effect and side-effect of the drugs].
abstract: The authors give an overview on the role of drug metabolizing enzymes in the effect and side-effect of drugs. They describe the properties of cytochrome P450 and other phase I enzymes (hydrolases, flavin-monooxygenases), as well as of phase II. enzymes (glucuronyl-, sulfate-, glutathione-, acetyl-, methyltranferases), their polymorphism, inductive and inhibition properties. The possible drug-drug interactions are discussed in detail.
authors.affiliation: Magyar Tudományos Akadémia, Kémiai Kutatóközpont, Farmakobiokémiai Osztály, Budapest. vela@chemres.hu
authors.forename: László
authors.initials: L
authors.lastname: Vereczkey
authors.forename: Katalin
authors.initials: K
authors.lastname: Jemnitz
authors.forename: Katalin
authors.initials: K
authors.lastname: Monostory
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Veres
authors.forename: László
authors.initials: L
authors.lastname: Kóbori
mesh_terms: D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000378:metabolism*; D004347:Drug Interactions; D004790:Enzyme Induction; D047309:Flavones / Q000378:metabolism; D006801:Humans; D006867:Hydrolases / Q000378:metabolism; D008780:Methyltransferases / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011110:Polymorphism, Genetic
chemical_list: D047309:Flavones; D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D008780:Methyltransferases; D006867:Hydrolases