Anti-HIV bioactive stilbene dimers of Caragana rosea.
Bioassay-guided fractionation of the ethanol extract of the aerial parts of Caragana rosea Turcz. led to the isolation of two new (cararosinol C and cararosinol D) and four known [scirpusin A (1), cis-scirpusin A (2), maackin (3), scirpusin B (4)] stilbene dimers. This is the first identification of these compounds from this plant and the first time that compound 2 has been isolated as a natural compound. Their structures were established mainly by spectral means. An in vitro assay against HIV-1 (IIIB), demonstrated compounds 1 and 4 to be active against HIV, with EC50 values of 10 microg/mL and 7 microg/mL respectively.
Yang
Guo-xun
GX
School of Pharmacy, Fudan University, Shanghai, P. R. China.
Zhou
Jin-tao
JT
Li
Ya-zun
YZ
Hu
Chang-qi
CQ
D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D032602:Caragana; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D020128:Inhibitory Concentration 50; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013267:Stilbenes / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D019380:Anti-HIV Agents; D010936:Plant Extracts; D013267:Stilbenes