title: Is the size of an abdominal aortic aneurysm associated with coagulopathy?
abstract: Abdominal aortic aneurysm (AAA) volume and intraluminal thrombi were analyzed with respect to the number and function of platelets, blood cells, and coagulation factors. A group of 43 patients who underwent repair of an AAA were enrolled in this study. The maximum diameter and volume of the AAA, and the volume of intraluminal thrombi and lumen were measured by computed tomography with planimetry. The platelet count and platelet function, prothrombin time, activated partial thromboplastin time, fibrinogen, plasminogen, antithrombin 3, fibrin degradation products (FDP), D-dimer, and blood cell counts were measured. Spontaneous platelet aggregation and the FDP, and D-dimer levels were elevated; all other factors remained within the normal range. Intraluminal thrombus volume was strongly correlated with the volume and diameter of the AAA. However, no correlation was observed between the size of the AAA and coagulating factors, including the number and aggregation value of platelets. AAAs are frequently associated with a coagulating disorder. However, its size and thrombus volume are not correlated with coagulation changes. Although an intraluminal thrombus increases along with fee enlargement of the AAA, the clinical manifestation of bleeding is rarely associated with an AAA. Therefore coagulopathy in patients with an AAA is not fully explained by its morphology.
authors.affiliation: Second Department of Surgery, Faculty of Medicine, University of Yamanashi, Tamaho-cho, Nakakoma-gun, Yamanashi, Japan. sshindo@vamanashi.ac.jp
authors.forename: Shunya
authors.initials: S
authors.lastname: Shindo
authors.forename: Harunobu
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Kenji
authors.initials: K
authors.lastname: Kubota
authors.forename: Atsuo
authors.initials: A
authors.lastname: Kojima
authors.forename: Masahiko
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Kaneo
authors.initials: K
authors.lastname: Satoh
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ozaki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000150:complications / Q000503:physiopathology*; D001779:Blood Coagulation Factors / Q000032:analysis; D001837:Body Weights and Measures; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D001779:Blood Coagulation Factors