title: Resolution of nocturnal enuresis in snoring children after treatment with nasal budesonide.
abstract: Nocturnal enuresis has been associated with obstructive sleep apnea-hypopnea and may resolve after adenotonsillectomy. Nasal corticosteroids have improved symptoms and polysomnography findings in children with snoring. Two children with primary nocturnal enuresis, chronic nasal obstruction, and loud snoring underwent polysomnography. The apnea-hypopnea index was 4.9 and 7.3 episodes/hr, and the oxygen desaturation of hemoglobin index was 4.6 and 5.2 episodes/hr. After administration of budesonide, the frequency of snoring decreased, the polysomnography findings improved, and the enuresis resolved completely. Six months after treatment, both children were still dry at night. Administration of nasal corticosteroids is associated with resolution of enuresis in children with mild obstructive sleep-disordered breathing.
authors.affiliation: Department of Pediatrics, University of Thessaly School of Medicine and Larissa University Hospital, Larissa, Greece. ealexop@yahoo.com
authors.forename: Emmanouel I
authors.initials: EI
authors.lastname: Alexopoulos
authors.forename: Athanasios G
authors.initials: AG
authors.lastname: Kaditis
authors.forename: Eleni
authors.initials: E
authors.lastname: Kostadima
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Gourgoulianis
mesh_terms: D000281:Administration, Intranasal; D019819:Budesonide / Q000008:administration & dosage*; D002648:Child; D004775:Enuresis / Q000150:complications* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D015508:Nasal Obstruction / Q000150:complications / Q000188:drug therapy; D012074:Remission Induction; D012913:Snoring / Q000150:complications* / Q000188:drug therapy*
chemical_list: D019819:Budesonide