title: A case of hypothyroidism and type 2 diabetes associated with type V hyperlipoproteinemia and eruptive xanthomas.
abstract: Primary hypothyroidism and type 2 diabetes are both typically associated with the increased level of triglycerides. To date, there have been only a few case reports of type 2 diabetes patients with both type V hyperlipoproteinemia and eruptive xanthomas, but there have been no reports of hypothyroidism patients associated with eruptive xanthomas. We report here on a case of a 48-yr old female patient who was diagnosed with type 2 diabetes and primary hypothyroidism associated with both type V hyperlipoproteinemia and eruptive xanthomas. We found rouleaux formation of RBCs in peripheral blood smear, elevated TSH, and low free T4 level, and dyslipidemia (total cholesterol 18.1 mM/L, triglyceride 61.64 mM/L, HDL 3.0 mM/L, and LDL 2.54 mM/L). She has taken fenofibrate, levothyroxine, and oral hypoglycemic agent for 4 months. After treatment, both TSH level and lipid concentration returned to normal range, and her yellowish skin nodules have also disappeared.
authors.affiliation: Department of Internal Medicine, College of Medicine, Gyeongsang National University, Jinju, Korea.
authors.forename: Jeong Rang
authors.initials: JR
authors.lastname: Park
authors.forename: Tae Sik
authors.initials: TS
authors.lastname: Jung
authors.forename: Jung Hwa
authors.initials: JH
authors.lastname: Jung
authors.forename: Gyeong-Won
authors.initials: GW
authors.lastname: Lee
authors.forename: Me Ae
authors.initials: MA
authors.lastname: Kim
authors.forename: Ki-Jong
authors.initials: KJ
authors.lastname: Park
authors.forename: Deok Ryong
authors.initials: DR
authors.lastname: Kim
authors.forename: Se-Ho
authors.initials: SH
authors.lastname: Chang
authors.forename: Soon Il
authors.initials: SI
authors.lastname: Chung
authors.forename: Jong Ryeal
authors.initials: JR
authors.lastname: Hahm
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D004903:Erythrocyte Aggregation; D005260:Female; D011345:Fenofibrate / Q000627:therapeutic use; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood; D006954:Hyperlipoproteinemia Type V / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D007037:Hypothyroidism / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D008875:Middle Aged; D012871:Skin Diseases / Q000097:blood / Q000150:complications / Q000188:drug therapy; D013972:Thyrotropin / Q000097:blood / Q000627:therapeutic use; D013974:Thyroxine / Q000097:blood; D016896:Treatment Outcome; D014973:Xanthomatosis / Q000097:blood / Q000150:complications* / Q000188:drug therapy
chemical_list: D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D013972:Thyrotropin; D013974:Thyroxine; D011345:Fenofibrate