Parenteral antioxidant treatment preserves temporal discrimination following intrahippocampal aggregated Abeta(1-42) injections.
There is evidence that oxidative stress may play a role in the neuropathology of Alzheimer's disease (AD). This study used an aggregated beta-amyloid (Abeta) injection model of AD in the rat, and a recycling conjunctive schedule of food reinforcement to examine the effects of bilateral intrahippocampal injections of aggregated Abeta(1-42) (5.0 microl/side) on temporal discrimination, and the efficacy of the antioxidant alpha-tocopherol (150 mg/kg daily p.o.) in alleviating these effects. The results indicated that bilateral intrahippocampal injections of aggregated Abeta(1-42) detrimentally affected temporal discrimination from five-day block 31-35 post-injections until the end of the study (90 days post-injections). Daily treatment with alpha-tocopherol improved temporal discrimination under the recycling conjunctive schedule following aggregated Abeta(1-42) injections from the five-day block 61-65 days until the end of the study.
McDaid
D G
DG
School of Psychology, University of Ulster, Newtownabbey, Co. Antrim, Northern Ireland.
Kim
E-M
EM
Reid
R E
RE
Leslie
J C
JC
Cleary
J
J
O'Hare
E
E
D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D004193:Discrimination Learning; D004192:Discrimination, Psychological / Q000187:drug effects*; D006624:Hippocampus / Q000502:physiology*; D007267:Injections; D008297:Male; D010446:Peptide Fragments / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013998:Time Perception / Q000187:drug effects; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology
D016229:Amyloid beta-Peptides; D000975:Antioxidants; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D014810:Vitamin E