title: Functional mapping of quantitative trait loci that interact with the hg mutation to regulate growth trajectories in mice.
abstract: The high growth (hg) mutation increases body size in mice by 30-50%. Given the complexity of the genetic regulation of animal growth, it is likely that the effect of this major locus is mediated by other quantitative trait loci (QTL) with smaller effects within a web of gene interactions. In this article, we extend our functional mapping model to characterize modifier QTL that interact with the hg locus during ontogenetic growth. Our model is derived within the maximum-likelihood context, incorporated by mathematical aspects of growth laws and implemented with the EM algorithm. In an F2 population founded by a congenic high growth (HG) line and non-HG line, a highly additive effect due to the hg gene was detected on growth trajectories. Three QTL located on chromosomes 2 and X were identified to trigger significant additive and/or dominant effects on the process of growth. The most significant finding made from our model is that these QTL interact with the hg locus to affect the shapes of the growth process. Our model provides a powerful means for understanding the genetic architecture and regulation of growth rate and body size in mammals.
authors.affiliation: Department of Statistics, University of Florida, Gainesville 32611, USA. rwu@stat.ufl.edu
authors.forename: Rongling
authors.initials: R
authors.lastname: Wu
authors.forename: Chang-Xing
authors.initials: CX
authors.lastname: Ma
authors.forename: Wei
authors.initials: W
authors.lastname: Hou
authors.forename: Pablo
authors.initials: P
authors.lastname: Corva
authors.forename: Juan F
authors.initials: JF
authors.lastname: Medrano
mesh_terms: D000367:Age Factors; D000465:Algorithms; D000818:Animals; D001835:Body Weight / Q000235:genetics / Q000502:physiology; D002874:Chromosome Mapping / Q000379:methods*; D004843:Epistasis, Genetic; D005260:Female; D005838:Genotype; D008297:Male; D051379:Mice / Q000235:genetics* / Q000254:growth & development; D020297:Mice, Congenic; D008810:Mice, Inbred C57BL; D008957:Models, Genetic; D009154:Mutation; D010641:Phenotype; D040641:Quantitative Trait Loci / Q000235:genetics*