title: Importance of extracolonic findings at IV contrast medium-enhanced CT colonography versus those at non-enhanced CT colonography.
abstract: To compare the clinical importance of extracolonic findings at intravenous (IV) contrast-enhanced CT colonography versus those at non-enhanced CT colonography. IV contrast medium-enhanced (n=72) and non-enhanced (n=30) multidetector CT colonography was performed in 102 symptomatic patients followed by conventional colonoscopy on the same day. The impact of extracolonic findings on further work up and treatment was assessed by a review of patient records. Extracolonic findings were divided into two groups: either leading to further work up respectively having an impact on therapy or not. A total of 303 extracolonic findings were detected. Of those, 71% (215/303) were found on IV contrast-enhanced CT, and 29% (88/303) were found on non-enhanced CT colonography. The extracolonic findings in 25% (26/102) of all patients led to further work up or had an impact on therapy. Twenty-two of these patients underwent CT colonography with IV contrast enhancement, and four without. The percentage of extracolonic findings leading to further work up or having an impact on therapy was higher for IV contrast-enhanced (31%; 22/72) than for non-enhanced (13%; 4/30) CT scans (P=0.12). IV contrast-enhanced CT colonography produced more extracolonic findings than non-enhanced CT colonography. A substantially greater proportion of findings on IV contrast-enhanced CT colonography led to further work up and treatment than did non-enhanced CT colonography.
authors.affiliation: Institute of Diagnostic Radiology, Inselspital, University of Bern, Freiburgstrasse 10, 3010, Bern, Switzerland.
authors.forename: Adrian
authors.initials: A
authors.lastname: Spreng
authors.forename: Peter
authors.initials: P
authors.lastname: Netzer
authors.forename: Joerg
authors.initials: J
authors.lastname: Mattich
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Dinkel
authors.forename: Peter
authors.initials: P
authors.lastname: Vock
authors.forename: Hanno
authors.initials: H
authors.lastname: Hoppe
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging; D003111:Colonic Polyps / Q000000981:diagnostic imaging; D023881:Colonography, Computed Tomographic / Q000379:methods; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging; D003287:Contrast Media / Q000008:administration & dosage*; D004938:Esophageal Neoplasms / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D017543:Iliac Aneurysm / Q000000981:diagnostic imaging; D007275:Injections, Intravenous; D008113:Liver Neoplasms / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011856:Radiographic Image Enhancement
chemical_list: D003287:Contrast Media