[Effects of surface modification of intraocular lenses on foreign body reaction ].
OBJECTIVE
In order to improve biocompatibility, we investigated the effects of surface modification by 2-methacryloyloxyethyl phosphorylcholine (MPC) on the foreign body reaction of intraocular lens (IOLs).


METHODS
Materials of the IOLs were polymethylmethacrylate, hydrophobic acryl, and MPC surface-modified hydrophobic IOLs (MPC modified acryl). In an in vitro study, cultured macrophages sampled from mouse intra-abdominal exudate were cultured on a plate for each IOL material. The cell density and morphology of attached cells on the IOL materials were investigated. In an in vivo study, each IOL material was implanted in the peritoneal space of mice and foreign body reaction was investigated with a light microscope and a scanning electron microscope.


RESULTS
In the in vitro study, the cells on the MPC modified acryl IOL material were remarkably fewer than those on the plates of the other two IOL materials. Regarding the implanted IOL matrevials, MPC modified acryl IOL material showed more polynuclear giant foreign body cells in the early period than the other two IOL materials.


CONCLUSIONS
MPC surface modification can reduce the foreign body reaction of IOLs and has the potential to improve biocompatibility of IOL materials.
Okajima
Yasuhiko
Y
Department of Ophthalmology, Nihon University School of Medicine, Japan.
Saika
Shizuya
S
Sawa
Mitsuru
M
D000818:Animals; D002448:Cell Adhesion; D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible; D005549:Foreign-Body Reaction; D007910:Lenses, Intraocular; D017737:Macrophages, Peritoneal / Q000276:immunology* / Q000473:pathology; D008297:Male; D008689:Methacrylates; D051379:Mice; D008810:Mice, Inbred C57BL; D010767:Phosphorylcholine / Q000031:analogs & derivatives*
D020099:Coated Materials, Biocompatible; D008689:Methacrylates; D010767:Phosphorylcholine; C070638:2-methacryloyloxyethyl phosphorylcholine