Modeling the Parkinson's tremor and its treatments.
In this paper, we discuss modeling issues of the Parkinson's tremor. Through the work we have employed physiological structure as well as functioning of the parts in brain that are involved in the disease. To obtain more practical similarity, random behaviors of the connection paths are also considered. Medication or treatment of the disease both by drug prescription and electrical signal stimulation are modeled based on the same model introduced for the disease itself. Two new medication strategies are proposed based on the model to reduce the side effects caused by the present drug prescription.
Haeri
Mohammad
M
Advanced Control Systems Lab, Electrical Engineering Department, Sharif University of Technology, Azadi Ave. PO. Box 11365-9363, Tehran, Iran. haeri@sina.sharif.edu
Sarbaz
Yashar
Y
Gharibzadeh
Shahriar
S
D000978:Antiparkinson Agents / Q000627:therapeutic use*; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D046690:Deep Brain Stimulation; D004298:Dopamine / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D004567:Electrodes, Implanted; D004576:Electromyography; D006225:Hand; D006801:Humans; D008954:Models, Biological; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology* / Q000628:therapy; D016896:Treatment Outcome; D014202:Tremor / Q000188:drug therapy / Q000503:physiopathology* / Q000628:therapy
D000978:Antiparkinson Agents; D004298:Dopamine