Prodrug activation gated by a molecular "OR" logic trigger.
Amir
Roey J
RJ
Department of Organic Chemistry, School of Chemistry, Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Popkov
Mikhail
M
Lerner
Richard A
RA
Barbas
Carlos F
CF
Shabat
Doron
D
D000903:Antibiotics, Antineoplastic / Q000737:chemistry; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004317:Doxorubicin / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005634:Fructose-Bisphosphate Aldolase / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000737:chemistry / Q000494:pharmacology; D008128:Logic; D008954:Models, Biological; D010399:Penicillin Amidase / Q000737:chemistry / Q000494:pharmacology; D011355:Prodrugs / Q000737:chemistry* / Q000494:pharmacology*
D000903:Antibiotics, Antineoplastic; D007140:Immunoglobulin Fab Fragments; D011355:Prodrugs; D004317:Doxorubicin; D010399:Penicillin Amidase; C109536:antibody aldolase; D005634:Fructose-Bisphosphate Aldolase