title: A novel, adenylate cyclase, signaling mechanism of relaxin H2 action.
abstract: For the first time, the adenylate cyclase signaling mechanism (ACSM) of the action of relaxin H2 was revealed and deciphered in human and rat muscle tissues. The comparative study of signaling blocks forming the ACSM of relaxin and insulin (discovered earlier) showed that the postreceptor signaling chain of relaxin coincides with that of insulin. However, the type of relaxin receptor involved in ACSM remains obscure. Currently, the ACSM of relaxin may be represented as a signaling cascade: receptor --> Gi protein (betagamma-dimer) --> phosphatidylinositol 3-kinase (PI3K) --> protein kinase Czeta (PKCzeta) --> Gs protein --> adenylate cyclase.
authors.affiliation: Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia. alex_shpakov@list.ru
authors.forename: Alexander
authors.initials: A
authors.lastname: Shpakov
authors.forename: Marianna
authors.initials: M
authors.lastname: Pertseva
authors.forename: Ludmila
authors.initials: L
authors.lastname: Kuznetsova
authors.forename: Svetlana
authors.initials: S
authors.lastname: Plesneva
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D005260:Female; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D009215:Myometrium / Q000187:drug effects / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism; D051381:Rats; D012065:Relaxin / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects*; D000099221:Protein Kinase C zeta
chemical_list: D000262:Adenylyl Cyclases; D007328:Insulin; D011493:Protein Kinase C; D012065:Relaxin; D000099221:Protein Kinase C zeta