title: Italian survey in postoperative radiation therapy for prostate carcinoma by the AIRO National Working Group on Prostate Radiotherapy: definitive results.
abstract: OBJECTIVE
  The National Working Group on Prostate Radiotherapy of AIRO (Associazione Italiana Radioterapia Oncologica, Italian Association of Radiotherapeutic Oncology) was established in March 2001. A retrospective multi-center survey was performed to analyze the patterns of care for prostate cancer patients treated with postoperative radiotherapy following radical prostatectomy in Italy with regard to the year 2000.
  
  
  METHODS
  A structured questionnaire was mailed to 47 Italian radiotherapy centers to assess patient accrual in the postoperative setting in the interval comprised between period January-December 2000. Numbers of patients treated for different stages, specific prognostic factors indicating the need for adjuvant radiotherapy, fractionation schedules and prescription doses were acquired as well as other clinically important factors such as radiotherapy timing and the use of hormone therapy. More technical features of the treatment, such as patient positioning, mode of simulation, typical field setup and dose prescription criteria were also included in the questionnaire.
  
  
  RESULTS
  The questionnaire was returned by 24 radiotherapy Institutions (51%) with a total number of 470 patients treated postoperatively in the year 2000. An average of about 20 patients were enrolled by each radiotherapy center. The age range was 45-81 years. Radiotherapy was delivered within 6 months of radical prostatectomy in 297 patients (65.4%) (mean, 3.4 months). In 157 (34.6%), the treatment was delivered as a salvage approach for biochemical or micro-macroscopic recurrence. Most of patients had locally advanced stage disease (pT3-pT4) (76%). Unfavorable prognostic factors, such as positive margins, capsular invasion, Gleason pattern score > 7 were present in about 50% of patients.
  
  
  CONCLUSIONS
  The study confirmed that important risk factors for recurrences are present in a significant percentage of patients treated by radical prostatectomy. The number of patients that would benefit from adjuvant radiotherapy is therefore potentially very large. Future prospective studies should be conducted to assess and to clarify the respective roles of adjuvant and salvage radiotherapy in prostate cancer patients.
authors.affiliation: AIRO (Associazione Italiana Radioterapia Oncologica) National Working Group on Prostate Radiotherapy, IRCC, Institute for Cancer Research and Treatment, Candiolo (Turin), Italy. gmalinverni@libero.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Malinverni
authors.forename: Carlo
authors.initials: C
authors.lastname: Greco
authors.forename: Pieromaria
authors.initials: P
authors.lastname: Bianchi
authors.forename: Luciano
authors.initials: L
authors.lastname: Busutti
authors.forename: Emanuela
authors.initials: E
authors.lastname: Cagna
authors.forename: Cesare
authors.initials: C
authors.lastname: Cozzarini
authors.forename: Massimo
authors.initials: M
authors.lastname: Del Duca
authors.forename: Paola
authors.initials: P
authors.lastname: Franzone
authors.forename: Giovanni
authors.initials: G
authors.lastname: Frezza
authors.forename: Pietro
authors.initials: P
authors.lastname: Gabriele
authors.forename: Domenico
authors.initials: D
authors.lastname: Genovesi
authors.forename: Giuseppe Franco
authors.initials: GF
authors.lastname: Girelli
authors.forename: Corrado
authors.initials: C
authors.lastname: Italia
authors.forename: Giovanni
authors.initials: G
authors.lastname: Mandoliti
authors.forename: Floranna
authors.initials: F
authors.lastname: Mauro
authors.forename: Simonetta
authors.initials: S
authors.lastname: Nava
authors.forename: Silvia
authors.initials: S
authors.lastname: Pratissoli
authors.forename: Maria Bianca
authors.initials: MB
authors.lastname: Saracino
authors.forename: Luigi
authors.initials: L
authors.lastname: Squillace
authors.forename: Marco
authors.initials: M
authors.lastname: Signor
authors.forename: Angiolo
authors.initials: A
authors.lastname: Tagliagambe
authors.forename: Vittorio
authors.initials: V
authors.lastname: Vavassori
authors.forename: Sergio
authors.initials: S
authors.lastname: Villa
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Zini
authors.forename: Riccardo
authors.initials: R
authors.lastname: Valdagni
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006306:Health Surveys; D006728:Hormones / Q000627:therapeutic use; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy*; D012189:Retrospective Studies; D012955:Societies, Medical; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D006728:Hormones