Severe hemolytic anemia due to auto anti-N.
Auto anti-N is infrequently encountered and, in most reported cases, does not cause clinical hemolysis. This case reports an auto anti-N associated with severe hemolytic anemia (Hb=2.7 g/dL) in a 6-year-old Caucasian girl with a history of vomiting, fever, and abdominal pain. Upon admission, she was found to have a metabolic acidosis, secondary to her severe anemia, with abnormal liver function tests. As in three other case reports, the autoimmune hemolytic anemia resolved, with disappearance of the auto anti-N, after corticosteroid therapy.
Immel
C C
CC
Transfusion Medicine Service, UNC Hospitals, 1021 East Wing, 101 Manning Drive, Chapel Hill, NC 27514, USA.
McPherson
M
M
Hay
S N
SN
Braddy
L R
LR
Brecher
M E
ME
D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood* / Q000188:drug therapy / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D001788:Blood Grouping and Crossmatching; D002648:Child; D005260:Female; D006461:Hemolysis; D006801:Humans; D008951:MNSs Blood-Group System
D000305:Adrenal Cortex Hormones; D001323:Autoantibodies; D008951:MNSs Blood-Group System