Psychosocial, cultural and genetic influences on alcohol use in Asian American youth.
OBJECTIVE
Environmental and cultural factors, as well as a genetic variant of the aldehyde dehydrogenase gene (the ALDH2*2 allele) have been identified as correlates of alcohol use among Asian Americans. However, concurrent examination of these variables has been rare. The present study assessed parental alcohol use, acculturation and ALDH2 gene status in relation to lifetime, current and heavy episodic drinking among Chinese and Korean American undergraduates.


METHODS
Participants (N = 428, 51% women; 52% Chinese American, age 18-19 years) were first-year college students in a longitudinal study of substance use initiation and progression. Data were collected via structured interview and self-report, and participants provided a blood sample for genotyping at the ALDH2 locus.


RESULTS
Gender, parental alcohol use and acculturation significantly predicted drinking behavior. However, none of the hypothesized moderating relationships were significant. In contrast with previous studies, ALDH2 gene status was not associated with alcohol use.


CONCLUSIONS
Results indicate that although the variables examined influence alcohol use, moderating effects were not observed in the present sample of Asian American college students. Findings further suggest that the established association of ALDH2 status and drinking behavior in Asians may not be evident in late adolescence. It is possible that ALDH2 status is associated with alcohol consumption only following initiation and increased drinking experience.
Hendershot
Christian S
CS
Veterans Affairs San Diego Healthcare System, San Diego, California 92161, USA.
MacPherson
Laura
L
Myers
Mark G
MG
Carr
Lucinda G
LG
Wall
Tamara L
TL
D000069:Acculturation; D000293:Adolescent; D000437:Alcoholism / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D000444:Aldehyde Dehydrogenase / Q000235:genetics; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D001213:Asian / Q000706:statistics & numerical data*; D003469:Culture; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011584:Psychology; D014481:United States / Q000453:epidemiology
C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial