Genetic lesions within the 3a gene of SARS-CoV.
A series of frameshift mutations within the 3a gene has been observed in culture-derived severe acute respiratory syndrome coronavirus (SARS-CoV). We report here that viral RNA from clinical samples obtained from SARS-CoV infected patients also contains a heterogeneous population of wild-type and mutant 3a transcripts.
Tan
Timothy H P
TH
Institute of Molecular and Cell Biology, 61 Biopolis Drive, 138673, Singapore. ttan@imcb.a-star.edu.sg
Barkham
Timothy
T
Fielding
Burtram C
BC
Chou
Chih-Fong
CF
Shen
Shuo
S
Lim
Seng Gee
SG
Hong
Wanjin
W
Tan
Yee-Joo
YJ
D016368:Frameshift Mutation; D006801:Humans; D012367:RNA, Viral / Q000235:genetics; D045473:Severe acute respiratory syndrome-related coronavirus / Q000235:genetics* / Q000302:isolation & purification*; D045169:Severe Acute Respiratory Syndrome / Q000821:virology*; D014759:Viral Envelope Proteins; D014764:Viral Proteins / Q000235:genetics*; D000086082:Viroporin Proteins
C487105:3a protein, SARS-CoV; D012367:RNA, Viral; D014759:Viral Envelope Proteins; D014764:Viral Proteins; D000086082:Viroporin Proteins