Persistent pulmonary hypertension of newborn due to congenital capillary alveolar dysplasia.
Congenital alveolar capillary dysplasia is a rare and fatal cause of pulmonary hypertension in neonates. We report on a term baby with severe pulmonary hypertension unresponsive to high-frequency ventilation and nitric oxide. A diagnosis of alveolar capillary dysplasia was established on autopsy. We review the literature regarding pathophysiology, clinical presentations, associated malformations, and treatment trials.
Singh
Soraisham Amuchou
SA
Division of Neonatology, Department of Pediatrics, Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada. amuchou@yahoo.com
Ibrahim
Thowfique
T
Clark
Deborah Jane
DJ
Taylor
Richard Scott
RS
George
David Hilles
DH
D002196:Capillaries / Q000002:abnormalities*; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology*; D007231:Infant, Newborn; D008168:Lung / Q000648:ultrastructure; D011650:Pulmonary Alveoli / Q000098:blood supply*