title: Development of Korean standard brain templates.
abstract: We developed age, gender and ethnic specific brain templates based on MR and Positron-Emission Tomography (PET) images of Korean normal volunteers. Seventy-eight normal right-handed volunteers (M/F=49/29) underwent 3D T1-weighted SPGR MR and F-18-FDG PET scans. For the generation of standard templates, an optimal target brain that has the average global hemispheric shape was selected for each gender. MR images were then spatially normalized by linear transformation to the target brains, and normalization parameters were reapplied to PET images. Subjects were subdivided into 2 groups for each gender: the young/midlife (<55 yr) and the elderly groups. Young and elderly MRI/PET templates were composed by averaging the spatially normalized images. Korean templates showed different shapes and sizes (mean length, width, and height of the brains were 16.5, 14.3 and 12.1 cm for man, and 15.6, 13.5 and 11.4 cm for woman) from the template based on Caucasian (18.3, 14.2, and 13.3 cm). MRI and PET templates developed in this study will provide the framework for more accurate stereotactic standardization and anatomical localization.
authors.affiliation: Korean Consortium for Brain Mapping, Department of Nuclear Medicine, Seoul National University College of Medicine.
authors.forename: Jae Sung
authors.initials: JS
authors.lastname: Lee
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Lee
authors.forename: Jinsu
authors.initials: J
authors.lastname: Kim
authors.forename: Yu Kyeong
authors.initials: YK
authors.lastname: Kim
authors.forename: Eunjoo
authors.initials: E
authors.lastname: Kang
authors.forename: Hyejin
authors.initials: H
authors.lastname: Kang
authors.forename: Keon Wook
authors.initials: KW
authors.lastname: Kang
authors.forename: Jong Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Jae-Jin
authors.initials: JJ
authors.lastname: Kim
authors.forename: Hae Jeong
authors.initials: HJ
authors.lastname: Park
authors.forename: Jun Soo
authors.initials: JS
authors.lastname: Kwon
authors.forename: Sun I
authors.initials: SI
authors.lastname: Kim
authors.forename: Tae Woo
authors.initials: TW
authors.lastname: Yoo
authors.forename: Kee Hyun
authors.initials: KH
authors.lastname: Chang
authors.forename: Myung Chul
authors.initials: MC
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007723:Korea; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods; D011859:Radiography; D012737:Sex Factors
chemical_list: D019788:Fluorodeoxyglucose F18