title: Gastric cytoprotective activity of ilicic aldehyde: structure-activity relationships.
abstract: A series of sesquiterpene compounds possessing both eudesmane and eremophilane skeletons were tested as gastric cytoprotective agents on male Wistar rats. The presence of an alpha,beta-unsaturated aldehyde on the C-7 side chain together with a hydroxyl group at C-4 is the requirement for the observed antiulcerogenic activity. In an attempt to establish new molecular structural requirements for this gastric cytoprotective activity, a structure-activity study was performed.
authors.affiliation: INTEQUI-CONICET, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, 5700 San Luis, Argentina. odonadel@unsl.edu.ar
authors.forename: Osvaldo J
authors.initials: OJ
authors.lastname: Donadel
authors.forename: Eduardo
authors.initials: E
authors.lastname: Guerreiro
authors.forename: Alejandra O
authors.initials: AO
authors.lastname: María
authors.forename: Graciela
authors.initials: G
authors.lastname: Wendel
authors.forename: Ricardo D
authors.initials: RD
authors.lastname: Enriz
authors.forename: Oscar S
authors.initials: OS
authors.lastname: Giordano
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Tonn
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000494:pharmacology*; D041981:Gastrointestinal Tract / Q000166:cytology / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology*; D013276:Stomach Ulcer / Q000188:drug therapy; D013329:Structure-Activity Relationship
chemical_list: D000897:Anti-Ulcer Agents; D012717:Sesquiterpenes; C456084:ilicic aldehyde