title: Tuberculosis due to resistant Haarlem strain, Tunisia.
abstract: Multidrug-resistant tuberculosis was diagnosed in 21 HIV-negative, nonhospitalized male patients residing in northern Tunisia. A detailed investigation showed accelerated transmission of a Mycobacterium tuberculosis clone of the Haarlem type in 90% of all patients. This finding highlights the epidemic potential of this prevalent genotype.
authors.affiliation: Institut Pasteur de Tunis, Tunis-Belvédère, Tunisia. helmi.merdassi@pasteur.rns.tn
authors.forename: Helmi
authors.initials: H
authors.lastname: Mardassi
authors.forename: Amine
authors.initials: A
authors.lastname: Namouchi
authors.forename: Raja
authors.initials: R
authors.lastname: Haltiti
authors.forename: Mourad
authors.initials: M
authors.lastname: Zarrouk
authors.forename: Besma
authors.initials: B
authors.lastname: Mhenni
authors.forename: Anis
authors.initials: A
authors.lastname: Karboul
authors.forename: Neila
authors.initials: N
authors.lastname: Khabouchi
authors.forename: Nico C
authors.initials: NC
authors.lastname: Gey van Pittius
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Streicher
authors.forename: Jean
authors.initials: J
authors.lastname: Rauzier
authors.forename: Brigette
authors.initials: B
authors.lastname: Gicquel
authors.forename: Koussay
authors.initials: K
authors.lastname: Dellagi
mesh_terms: D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000494:pharmacology*; D015373:Bacterial Typing Techniques; D004251:DNA Transposable Elements; D024881:Drug Resistance, Bacterial / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000187:drug effects* / Q000235:genetics; D009841:Oligonucleotides / Q000032:analysis; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D015995:Prevalence; D018088:Tuberculosis, Multidrug-Resistant / Q000453:epidemiology* / Q000382:microbiology / Q000635:transmission; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology* / Q000382:microbiology / Q000635:transmission; D014416:Tunisia / Q000453:epidemiology
chemical_list: D000995:Antitubercular Agents; D004251:DNA Transposable Elements; D009841:Oligonucleotides