Effects of acupuncture at GV01 on experimentally induced colitis in rats: possible involvement of the opioid system.
Oriental medicine uses acupuncture at the GV01 acupoint with great success to treat diarrhea. It significantly reduced the colonic motility and inflammation in colitic rats. Naloxone pretreatment blocked these effects. The therapeutic effects of acupuncture at GV01 in colitis may involve endogenous opioid pathways.
Kim
Hee-Young
HY
Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung Hee University, Kyunggi-do 449-701, South Korea.
Hahm
Dae-Hyun
DH
Pyun
Kwang-Ho
KH
Lee
Seung-Ki
SK
Lee
Hye-Jung
HJ
Nam
Tchi-Chou
TC
Shim
Insop
I
D015669:Acupuncture Points; D015670:Acupuncture Therapy; D000818:Animals; D003092:Colitis / Q000139:chemically induced / Q000473:pathology / Q000628:therapy*; D003106:Colon / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D004195:Disease Models, Animal; D005769:Gastrointestinal Motility / Q000187:drug effects; D007279:Injections, Subcutaneous; D008297:Male; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014302:Trinitrobenzenesulfonic Acid
D009292:Narcotic Antagonists; D009270:Naloxone; D014302:Trinitrobenzenesulfonic Acid; D009195:Peroxidase