title: Dietary conjugated linoleic acid increases endurance capacity and fat oxidation in mice during exercise.
abstract: Ingestion of CLA activates beta-oxidation and causes loss of body fat in rodents. We investigated the effects of dietary CLA on endurance capacity and energy metabolism during exercise in mice. Five-week-old male BALB/c mice were fed a control diet containing 1.0% linoleic acid or a diet containing 0.5% CLA that replaced an equivalent amount of linoleic acid for 1 wk. The maximum swimming time until fatigue was significantly higher in the CLA-fed group than in the control group. During treadmill running, the respiratory exchange ratio was significantly lower in the CLA-fed group, but oxygen consumption did not differ significantly between groups, suggesting that FA contributed more as an energy substrate in the CLA-fed mice. The muscle lipoprotein lipase activity was significantly higher in the CLA-fed group than in the control group. These results suggest that CLA ingestion increases endurance exercise capacity by promoting fat oxidation during exercise.
authors.affiliation: Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Mizunoya
authors.forename: Satoshi
authors.initials: S
authors.lastname: Haramizu
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Shibakusa
authors.forename: Yuki
authors.initials: Y
authors.lastname: Okabe
authors.forename: Tohru
authors.initials: T
authors.lastname: Fushiki
mesh_terms: D000818:Animals; D004041:Dietary Fats; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D023421:Models, Animal; D018763:Muscle Fatigue / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects*; D010805:Physical Conditioning, Animal; D010807:Physical Endurance / Q000187:drug effects / Q000502:physiology*; D013550:Swimming
chemical_list: D004041:Dietary Fats; D044243:Linoleic Acids, Conjugated