alpha-MSH enhances activity-based anorexia.
Activity-based anorexia (ABA) is considered an animal model of anorexia nervosa (AN). In ABA, scheduled feeding in combination with voluntary access to running wheels, results in hyperactivity, hypophagia, body weight loss and activation of the HPA axis. Since stimulation of the melanocortin (MC) system has similar effects, this system is a candidate system involved in ABA. Here it is shown that chronic alpha-MSH treatment enhances ABA by increasing running wheel activity (RWA), decreasing food intake and increasing HPA axis activation.
Hillebrand
Jacquelien J G
JJ
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3594 CG Utrecht, The Netherlands.
Kas
Martien J H
MJ
Adan
Roger A H
RA
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D000855:Anorexia / Q000378:metabolism* / Q000503:physiopathology*; D000856:Anorexia Nervosa / Q000378:metabolism / Q000503:physiopathology; D001835:Body Weight / Q000502:physiology; D004195:Disease Models, Animal; D004435:Eating / Q000502:physiology; D005260:Female; D005082:Physical Exertion / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D000521:alpha-MSH / Q000502:physiology*
D000521:alpha-MSH; D000324:Adrenocorticotropic Hormone