title: Effects of weight loss after gastric bypass on right and left ventricular function assessed by tissue Doppler imaging.
abstract: To evaluate the effects of substantial weight loss on tissue Doppler imaging parameters of right ventricular (RV) and left ventricular (LV) systolic and diastolic function, we performed standard echocardiography and tissue Doppler imaging in 17 patients with severe obesity before and after gastric bypass. Patients lost 39 +/- 10 kg over 7.6 +/- 3.6 months. Adjusted LV mass decreased (134 +/- 41 to 119 +/- 31 kg/m, p = 0.031). After weight loss, the ratios of early-to-late diastolic mitral and tricuspid inflow velocities increased (1.3 +/- 0.2 to 1.6 +/- 0.5, p = 0.02; 1.0 +/- 0.1 to 1.6 +/- 0.3, p = 0.003). Early diastolic tissue Doppler velocities increased at both the lateral and septal mitral annulus (7.6 +/- 1.5 to 9.3 +/- 2.5 cm/s, p = 0.009; and 6.6 +/- 1.4 to 7.7 +/- 1.7 cm/s; p = 0.028, respectively) and for their 2-site average (7.2 +/- 1.0 to 8.5 +/- 1.7 cm/s, p = 0.007). Early diastolic tricuspid annular velocity increased (7.2 +/- 2.8 to 10.6 +/- 2.3 cm/s, p <0.001) as did the ratio of early-to-late tricuspid annular diastolic velocity (0.9 +/- 0.4 to 1.1 +/- 0.2, p = 0.038). Tricuspid annular systolic velocity increased (8.6 +/- 2.5 to 10.3 +/- 2.7 cm/s, p = 0.037). In patients with severe obesity, significant weight loss results in an increase in tricuspid annular systolic and early diastolic velocities and mitral annular early diastolic velocities.
authors.affiliation: Department of Medicine, Division of Cardiology, University of Miami School of Medicine, Miami, Florida 33021-8437, USA. hjwillens@msn.com
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Willens
authors.forename: Simon C
authors.initials: SC
authors.lastname: Chakko
authors.forename: Patricia
authors.initials: P
authors.lastname: Byers
authors.forename: Julio A
authors.initials: JA
authors.lastname: Chirinos
authors.forename: Eugenio
authors.initials: E
authors.lastname: Labrador
authors.forename: Juan C
authors.initials: JC
authors.lastname: Castrillon
authors.forename: Maureen H
authors.initials: MH
authors.lastname: Lowery
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D018618:Echocardiography, Doppler, Color; D005260:Female; D005500:Follow-Up Studies; D015390:Gastric Bypass; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008943:Mitral Valve / Q000000981:diagnostic imaging; D009200:Myocardial Contraction / Q000502:physiology; D009767:Obesity, Morbid / Q000601:surgery*; D011184:Postoperative Period; D014261:Tricuspid Valve / Q000000981:diagnostic imaging; D016276:Ventricular Function; D016277:Ventricular Function, Left / Q000502:physiology*; D016278:Ventricular Function, Right / Q000502:physiology*; D015431:Weight Loss / Q000502:physiology*