title: Pharmacokinetics of once-daily lopinavir/ritonavir and the influence of dose modifications.
abstract: We studied the pharmacokinetics of lopinavir/ritonavir dosed at 800/200 mg a day in 20 HIV-1-infected patients, and evaluated the effect of dose modifications in the case of trough concentration (Ctrough) levels less than 1.0 mg/l. Ctrough levels after the daily administration of lopinavir/ritonavir were lower than with twice daily administration. Dose modifications in four patients with Ctrough levels less than 1.0 mg/l succeeded in only one patient. Therapeutic drug monitoring can identify patients with lower-than-expected lopinavir exposure in a larger study.
authors.affiliation: Department of Clinical Pharmacy, Radboud University Medical Centre, Nijmegen, The Netherlands.
authors.forename: Charles J L
authors.initials: CJ
authors.lastname: la Porte
authors.forename: Emile F
authors.initials: EF
authors.lastname: Schippers
authors.forename: Marchina E
authors.initials: ME
authors.lastname: van der Ende
authors.forename: Peter P
authors.initials: PP
authors.lastname: Koopmans
authors.forename: Willem L
authors.initials: WL
authors.lastname: Blok
authors.forename: Robbert H
authors.initials: RH
authors.lastname: Kauffmann
authors.forename: Frank P
authors.initials: FP
authors.lastname: Kroon
authors.forename: David M
authors.initials: DM
authors.lastname: Burger
mesh_terms: D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000493:pharmacokinetics*; D006801:Humans; D061466:Lopinavir; D008297:Male; D011744:Pyrimidinones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019438:Ritonavir / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D004338:Drug Combinations; D017320:HIV Protease Inhibitors; D011744:Pyrimidinones; D061466:Lopinavir; D019438:Ritonavir