Synthesis of cationic beta-vinyl substituted meso-tetraphenylporphyrins and their in vitro activity against herpes simplex virus type 1.
An easy route to cationic beta-vinyl substituted meso-tetraphenylporphyrin derivatives is described. Two novel compounds were tested in vitro for their antiviral photoactivity against herpes simplex virus type 1. One of these compounds exhibited a significant activity, reaching 99% of virus inactivation after 15 min of photoactivation.
Silva
Eduarda M P
EM
Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Giuntini
Francesca
F
Faustino
Maria A F
MA
Tomé
João P C
JP
Neves
Maria G P M S
MG
Tomé
Augusto C
AC
Silva
Artur M S
AM
Santana-Marques
Maria G
MG
Ferrer-Correia
António J
AJ
Cavaleiro
José A S
JA
Caeiro
Maria F
MF
Duarte
Ricardo R
RR
Tavares
Sabina A P
SA
Pegado
Inês N
IN
d'Almeida
Bruno
B
De Matos
António P A
AP
Valdeira
Maria L
ML
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000528:radiation effects; D002412:Cations / Q000737:chemistry; D049109:Cell Proliferation / Q000187:drug effects; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010777:Photochemistry; D011166:Porphyrins / Q000138:chemical synthesis / Q000494:pharmacology / Q000528:radiation effects; D013329:Structure-Activity Relationship; D014466:Ultraviolet Rays; D014709:Vero Cells; D014753:Vinyl Compounds / Q000138:chemical synthesis / Q000494:pharmacology / Q000528:radiation effects
D000998:Antiviral Agents; D002412:Cations; D011166:Porphyrins; D014753:Vinyl Compounds; C409084:tetraphenylporphyrin