[Immunogenetic analysis of human leukocyte antigen DRB1, DQB1 locus among Han ethnic children with Helicobacter pylori infection in Kunming].
OBJECTIVE
To explore the immunogenetic features of human leukocyte antigen DRB1, DQB1 locus and children with Helicobacter pylori (H. pylori) infection in Han ethnic population in Kunming and its association with digestive diseases and H. pylori to better understand the immunogenetic features of the H. pylori infection.


METHODS
Polymerase chain reaction-sequence specific primer (PCR-SSP) method was used to study the HLA-DRB1, DQB1 allelic frequency distribution on 35 children with H. pylori infection and 37 healthy controls in Han ethnic population in Kunming.


RESULTS
Allelic frequencies of HLA-DRB1 * 0901, DQB1 * 03032 in the H. pylori infection group were lower than those of the healthy control group (7.14% vs. 31.08%, chi(2) = 13.16, Pc < 0.012; 5.71% vs. 25.68%, chi(2) = 10.68, Pc = 0.007) but the rest alleles' frequencies did not show significant differences.


CONCLUSIONS
These result suggested that HLA-DRB1 * 0901, DQB1 * 03032 might protect the H. pylori infection in Han ethnic population in Kunming.
Wen
Ge-sheng
GS
Department of Pediatrics, The first Affiliated Hospital of Kunming Medical College, Kunming 650032, China.
Huang
Yong-kun
YK
Hao
Ping
P
Li
Hai-lin
HL
Qi
Qin
Q
Zhou
Li-fang
LF
D000293:Adolescent; D000483:Alleles; D002648:Child; D002681:China / Q000453:epidemiology / Q000208:ethnology; D005260:Female; D006683:HLA-DQ Antigens / Q000235:genetics* / Q000276:immunology; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics* / Q000276:immunology; D059811:HLA-DRB1 Chains; D016481:Helicobacter Infections / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction
D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains