title: Effect of orally administered omeprazole on abomasal luminal pH in dairy calves fed milk replacer.
abstract: The objective of this study was to determine whether oral administration of omeprazole, a proton-pump inhibitor, increased abomasal luminal pH in calves fed milk replacer. Four male dairy calves with cannulae in the abomasal body suckled milk replacer (60 ml/kg body weight every 12 h) and were administered a non-enteric-coated omeprazole (4 mg/kg body weight every 24 h) in a paste formulation for five successive days. Abomasal luminal pH was continuously measured using miniature glass pH electrodes. On the first day of omeprazole administration, there was a significant (P<0.05) increase in mean 24-h pH from 2.89 to 4.17. The mean 24-h pH on days 2, 3, 4 and 5 of omeprazole administration were 3.85, 4.02, 3.97 and 3.39 respectively. We conclude that oral administration of non-enteric-coated omeprazole increased abomasal luminal pH in calves fed milk replacer, but that the effect may decrease over time.
authors.affiliation: Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt.
authors.forename: A F
authors.initials: AF
authors.lastname: Ahmed
authors.forename: P D
authors.initials: PD
authors.lastname: Constable
authors.forename: N A
authors.initials: NA
authors.lastname: Misk
mesh_terms: D000018:Abomasum / Q000187:drug effects* / Q000502:physiology; D000284:Administration, Oral; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000831:Animals, Newborn; D000833:Animals, Suckling; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006863:Hydrogen-Ion Concentration; D008297:Male; D009853:Omeprazole / Q000008:administration & dosage / Q000494:pharmacology*; D013276:Stomach Ulcer / Q000517:prevention & control / Q000662:veterinary*
chemical_list: D000897:Anti-Ulcer Agents; D004791:Enzyme Inhibitors; D009853:Omeprazole