[Antiviral activity of oral ultralow doses of antibodies to gamma-interferon: experimental study of influenza infection in mice].
Course intragastric administration of ultralow doses of human gamma-interferon antibodies (ULD anti-IFN-gamma) to intact mice resulted in an increase of endogenous IFN-gamma production by the animal lymphocytes. Oral prophylactic administration of ULD anti-IFN-gamma significantly lowered the influenza virus concentration in the animal lungs at the initial stage of the aerogenous infection: in 2 (p = 0.05) and 3 (p = 0.07) days after the contamination. The therapeutic antiviral effect of ULD anti-IFN-gamma in mice with influenza was evident from a significant decrease of the influenza virus concentration in the lungs of the animals on the 4th (p = 0.05) and 5th (p = 0.07) days after the contamination. The antiviral effect of ULD anti-IFN-gamma after the prophylactic and therapeutic use is likely provided by induction of endogenous IFN-gamma.
Sergeev
A N
AN
P'iankov
O V
OV
Shishkina
L N
LN
Duben'
L G
LG
Petrishchenko
V A
VA
Zhukov
V A
VA
P'iankova
O G
OG
Sviatchenko
L I
LI
Sherstoboev
E Iu
EIu
Karimova
T V
TV
Martiushev-Poklad
A V
AV
Sergeeva
S A
SA
Epshteĭn
O I
OI
Glotov
A G
AG
Glotova
T I
TI
D000818:Animals; D000906:Antibodies / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D009980:Influenza A virus / Q000302:isolation & purification; D007371:Interferon-gamma / Q000096:biosynthesis / Q000276:immunology*; D008168:Lung / Q000276:immunology / Q000821:virology; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000517:prevention & control* / Q000628:therapy / Q000821:virology; D013154:Spleen / Q000276:immunology; D013997:Time Factors
D000906:Antibodies; D000998:Antiviral Agents; D007371:Interferon-gamma