title: Brachial artery flow-mediated dilation and myocardial perfusion in patients with cardiac syndrome X.
abstract: We assessed the relation between systemic endothelial dysfunction abnormalities (brachial artery flow-mediated dilation) and myocardial perfusion abnormalities (single-photon emission computed tomography) in 41 patients who had cardiac syndrome X. Eighteen patients had normal perfusion scans and 18 had transient perfusion defects. Reverse redistribution was found in 5 patients. Patients who had myocardial perfusion defects had significantly lower flow-mediated dilation values (1.8%) than patients who had normal single-photon emission computed tomograms (3.9%, p = 0.012). Preserved systemic endothelial function appears to rule out the occurrence of transient single-photon emission computed tomographic defects in patients who have cardiac syndrome X.
authors.affiliation: Cardiovascular Research Unit, Department of Cardiac and Vascular Sciences, St. George's Hospital Medical School, London, United Kingdom.
authors.forename: Pier Giorgio
authors.initials: PG
authors.lastname: Masci
authors.forename: Martin
authors.initials: M
authors.lastname: Laclaustra
authors.forename: Juan Garcia
authors.initials: JG
authors.lastname: Lara
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Kaski
mesh_terms: D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology*; D003326:Coronary Circulation / Q000187:drug effects / Q000502:physiology*; D004176:Dipyridamole; D004562:Electrocardiography; D004730:Endothelium, Vascular / Q000503:physiopathology; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D017566:Microvascular Angina / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008875:Middle Aged; D011237:Predictive Value of Tests; D013793:Thallium / Q000008:administration & dosage; D015899:Tomography, Emission-Computed, Single-Photon; D014463:Ultrasonography; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*; D014665:Vasodilator Agents
chemical_list: D014665:Vasodilator Agents; C027549:thallium chloride; D004176:Dipyridamole; D013793:Thallium