Maternal treatment with MCI-186 does not improve delayed deterioration of cellular bioenergetic state and mitochondrial activity following transient intrauterine ischemia in the fetal rat brain.
The mitochondrial respiratory activities and energy metabolism in the fetal rat brain were measured at the end of 30 minutes of intrauterine ischemia and after 2 and 4 hours of recirculation. The transient ischemia was associated with a delayed deterioration of cellular bioenergetic state and mitochondrial activities. The deterioration was not prevented by a free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), given immediately after recirculation.
Yokota
Akishige
A
Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan.
Nakai
Akihito
A
Taniuchi
Yoshinari
Y
Okuda
Naotaka
N
Nakai
Masako
M
Takeshita
Toshiyuki
T
D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism; D002545:Brain Ischemia / Q000378:metabolism*; D000077553:Edaravone; D004734:Energy Metabolism / Q000187:drug effects*; D005260:Female; D005311:Fetal Hypoxia / Q000378:metabolism*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D008928:Mitochondria / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000378:metabolism
D016166:Free Radical Scavengers; D000077553:Edaravone; D000983:Antipyrine