Mx scripts library: structural equation modeling scripts for twin and family data.
Structural equation modeling (SEM) provides a flexible tool to carry out genetic analyses of family and twin data. The basic model which decomposes the variance between and within families for a particular trait into genetic and non-genetic components can be generalized to multivariate and/or longitudinal data, incorporate sex differences in parameter estimates, and model the effects of measured environment, candidate genes or DNA marker data. We introduce a web-based library (http://www.psy.vu.nl/mxbib) of scripts for uni- and multivariate genetic epidemiological analyses, as well as for linkage and genetic association tests. The scripts are written to be used with the freely available software package Mx and provide a flexible and uniform approach to the analysis of data from relatives.
Posthuma
D
D
Department of Biological Psychology, Vrije Universiteit, Van der Boechorststraat 1, 1081, BT, Amsterdam, The Netherlands.
Boomsma
D I
DI
D004247:DNA; D005819:Genetic Markers; D006801:Humans; D040582:Inheritance Patterns; D008137:Longitudinal Studies; D015233:Models, Statistical; D015999:Multivariate Analysis; D012737:Sex Factors; D012984:Software; D018433:Twin Studies as Topic
D005819:Genetic Markers; D004247:DNA