Polymorphisms of high-affinity IgE receptor and histamine-related genes in patients with ASA-induced urticaria/angioedema.
The pathogenic mechanism of ASA-induced urticaria/angioedema (AIU) is still poorly understood, but it has been known that histamine releasing by cutaneous mast cell activation is considered to be an important role. Considering the importance of histamine in AIU, we speculated that a genetic abnormality of histamine-related genes such as a high-affinity IgE receptor, a metabolic enzyme of histamines and histamine receptors, may be involved in the development of AIU. Enrolled in the study were 110 patients with AIU, 53 patients without ASA hypersensitivity who had various drug allergies presenting as exanthematous skin symptoms, and 99 normal healthy controls (NC). Eleven single nucleotide polymorphisms (SNPs) of the beta chain of the high-affinity IgE receptor (FCER1B) and three histamine-related genes-histamine N-methyltransferase (HNMT), histamine H1 receptor (HRH1), histamine H2 receptor (HRH2)-were screened using the SNP-IT assay based on a single base extension method. No significant differences were observed in allele and genotype frequencies, and haplotype frequencies of all the SNPs of FCER1B, HNMT, HRH1, and HRH2 among the three groups (p>0.05, respectively). These results suggest that the polymorphisms of FCER1B and the three histamine-related genes may not contribute to the development of AIU phenotype in the Korean population.
Choi
Jeong-Hee
JH
Department of Pulmonology and Allergy, Bundang Jesaeng General Hospital, Seongnam, Korea.
Kim
Seung-Hyun
SH
Suh
Chang-Hee
CH
Nahm
Dong-Ho
DH
Park
Hae Sim
HS
D000328:Adult; D000483:Alleles; D000799:Angioedema / Q000139:chemically induced / Q000235:genetics* / Q000378:metabolism; D001241:Aspirin; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006632:Histamine / Q000378:metabolism*; D006636:Histamine Release / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017455:Receptors, IgE / Q000235:genetics*; D014581:Urticaria / Q000139:chemically induced / Q000235:genetics* / Q000378:metabolism
D017455:Receptors, IgE; D006632:Histamine; D001241:Aspirin