title: Association of CTLA4 polymorphism with regulatory T cell frequency.
abstract: A common single nucleotide polymorphism in CTLA4 has been linked with susceptibility and outcome in autoimmune and infectious diseases, respectively. Here, we show that this polymorphism is associated with the frequency of CD4(+)CD25(+) regulatory T cells in healthy human volunteers. We further show that, on a per cell basis, such regulatory T cells appear to be functionally indistinguishable across CTLA4 genotypes. These data implicate CTLA4 in regulatory T cell development, and provide a mechanism to account for the link between polymorphisms at this locus and the biological outcome of adaptive immune responses to self and to pathogens.
authors.affiliation: Division of Molecular Immunology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
authors.forename: Sowsan F
authors.initials: SF
authors.lastname: Atabani
authors.forename: Chloe L
authors.initials: CL
authors.lastname: Thio
authors.forename: Senad
authors.initials: S
authors.lastname: Divanovic
authors.forename: Aurelien
authors.initials: A
authors.lastname: Trompette
authors.forename: Yasmine
authors.initials: Y
authors.lastname: Belkaid
authors.forename: David L
authors.initials: DL
authors.lastname: Thomas
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Karp
mesh_terms: D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000235:genetics*; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology* / Q000276:immunology*; D060908:CTLA-4 Antigen; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D016176:T-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology
chemical_list: D015703:Antigens, CD; D000943:Antigens, Differentiation; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human