title: Mechanism of bone incorporation of beta-TCP bone substitute in open wedge tibial osteotomy in patients.
abstract: A histological study was performed of bone biopsies from 16 patients (17 biopsies) treated with open wedge high tibial osteotomies for medial knee osteoarthritis. The open wedge osteotomies were filled with a wedge of osteoconductive beta tricalcium phosphate (beta-TCP) ceramic bone replacement. At the time of removal of the fixation material, core biopsies of the area where the beta-TCP was located were taken at different follow-up periods (6-25 months). beta-TCP resorption, bone ingrowth and bone remodelling were studied. We hypothesized that the incorporation and remodelling process occurs similarly as in animals. Histology showed a good resorption of the beta-TCP with complete incorporation and remodelling into new bone. The different phases as described in animal studies were found. A correlation was found between histological findings and radiological assessment. In conclusion, beta-TCP appeared to be a bone replacement material with optimal biocompatibility, resorption characteristics and bone conduction properties for the clinical use.
authors.affiliation: Laboratory of Orthopaedic Research, Department Orthopaedics, University Hospital Nijmegen, Th. Craanenlaan 7, 6525 GH, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: Robert D A
authors.initials: RD
authors.lastname: Gaasbeek
authors.forename: Hanneke G
authors.initials: HG
authors.lastname: Toonen
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: van Heerwaarden
authors.forename: Pieter
authors.initials: P
authors.lastname: Buma
mesh_terms: D000328:Adult; D001672:Biocompatible Materials / Q000737:chemistry*; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry*; D001842:Bone and Bones / Q000378:metabolism*; D002130:Calcium Phosphates / Q000737:chemistry*; D006801:Humans; D008875:Middle Aged; D016348:Osseointegration; D020370:Osteoarthritis, Knee / Q000378:metabolism; D010010:Osteoclasts / Q000166:cytology; D010012:Osteogenesis; D010027:Osteotomy / Q000379:methods*; D013499:Surface Properties; D013977:Tibia / Q000473:pathology*; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; C018392:tricalcium phosphate