Pregnancy hormone concentrations across ethnic groups: implications for later cancer risk.
A variety of in utero factors have been associated with risk of adult cancers, particularly birth weight, toxemia, and gestational age. These factors are thought to reflect hormonal exposures during pregnancy. We hypothesized that the prenatal hormonal milieu may explain part of the variation in cancer rates across ethnic groups, for example, the higher incidence of breast cancer in the Caucasian compared with Hispanic women and the higher incidence of prostate and lower incidence of testicular cancers among African-Americans compared with Caucasians. We measured hormones in early pregnancy blood samples from three ethnic groups in a health care plan in Boston, MA. Mean levels of androstenedione, testosterone, estrone, and prolactin were significantly lower in Caucasian women compared with Hispanic women. Although not statistically significant, estradiol levels were lower in Caucasian compared with Hispanic or African-American women. Concentrations of androstenedione, testosterone, and progesterone were notably higher in African-American compared with Caucasian or Hispanic women. These data are consistent with hypotheses that in utero hormonal exposures may explain some of the ethnic group differences in cancer risk.
Potischman
Nancy
N
Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, 4005 EPN, 6130 Executive Boulevard, Bethesda, Maryland 20892-7344, USA. potischn@mail.nih.gov
Troisi
Rebecca
R
Thadhani
Ravi
R
Hoover
Robert N
RN
Dodd
Kevin
K
Davis
William W
WW
Sluss
Patrick M
PM
Hsieh
Chung-Cheng
CC
Ballard-Barbash
Rachel
R
D000328:Adult; D000735:Androstenedione / Q000097:blood; D044383:Black People; D015331:Cohort Studies; D005006:Ethnicity / Q000706:statistics & numerical data*; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D015994:Incidence; D009369:Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology*; D011247:Pregnancy / Q000502:physiology*; D011297:Prenatal Exposure Delayed Effects; D011374:Progesterone / Q000097:blood; D012307:Risk Factors; D013739:Testosterone / Q000097:blood; D044465:White People; D001741:Black or African American
D013739:Testosterone; D000735:Androstenedione; D011374:Progesterone