title: Fluid shifts have no influence on ciprofloxacin pharmacokinetics in intensive care patients with intra-abdominal sepsis.
abstract: This study aimed to investigate whether fluid shifts alter ciprofloxacin pharmacokinetics in critically ill patients over time. Patients > or = 18 years, with normal renal function, requiring intensive care treatment and parenteral antibiotics were enrolled. Group A (22 patients) included patients with documented intra-abdominal infections. Group B (18 patients) included patients with severe sepsis from other causes. All patients received intravenous ciprofloxacin 400 mg every 8 h infused over 60 min. Eight timed blood specimens were taken on days 0, 2 and 7. Ciprofloxacin plasma concentrations were determined using high performance liquid chromatography. There were no significant differences between the pharmacokinetics of the two groups or over time. Ciprofloxacin pharmacokinetics in critically ill patients do not change over time, and intra-abdominal sepsis does not alter ciprofloxacin pharmacokinetic parameters to a greater degree than sepsis from other causes in critically ill patients.
authors.affiliation: School of Pharmacy, University of Limpopo, P.O. Box 218, Medunsa 0204, South Africa.
authors.forename: Andries
authors.initials: A
authors.lastname: Gous
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Lipman
authors.forename: Juan
authors.initials: J
authors.lastname: Scribante
authors.forename: Shephelia
authors.initials: S
authors.lastname: Tshukutsoane
authors.forename: Hubert
authors.initials: H
authors.lastname: Hon
authors.forename: Mary
authors.initials: M
authors.lastname: Pinder
authors.forename: Rudo
authors.initials: R
authors.lastname: Mathivha
authors.forename: Lia
authors.initials: L
authors.lastname: Verhoef
authors.forename: Heino
authors.initials: H
authors.lastname: Stass
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy*; D001825:Body Fluid Compartments / Q000502:physiology*; D002939:Ciprofloxacin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin