title: Chiral Brønsted acid catalyzed enantioselective hydrophosphonylation of imines: asymmetric synthesis of alpha-amino phosphonates.
abstract: [reaction: see text] A cyclic phosphoric acid derivative, derived from (R)-BINOL, was used as a chiral Brønsted acid (10 mol %) in hydrophosphonylation of aldimines with diisopropyl phosphite at room temperature. Alpha-amino phosphonates were obtained with good to high enantioselectivities.
authors.affiliation: Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1 Mejiro, Toshima-ku, Tokyo 171-8588, Japan. takahiko.akiyama@gakushuin.ac.jp
authors.forename: Takahiko
authors.initials: T
authors.lastname: Akiyama
authors.forename: Hisashi
authors.initials: H
authors.lastname: Morita
authors.forename: Junji
authors.initials: J
authors.lastname: Itoh
authors.forename: Kohei
authors.initials: K
authors.lastname: Fuchibe