title: Reye's syndrome developing in an infant on treatment of Kawasaki syndrome.
abstract: Aspirin is commonly used as an anti-inflammatory therapy for Kawasaki syndrome. Early initiation with high dose aspirin (80 to > 100 mg/kg per day), followed by low-dose therapy at the afebrile stage, has been often used to reduce morbidity and mortality in coronary complications. We report a 10-month-old infant who was diagnosed with Kawasaki syndrome. Sudden onset of poor activity, poor appetite, lethargy, tachycardia, tachypnea, hepatomegaly, increased AST/ALT, coagulopathy and hyperammonemia developed 3 days after the high-dose aspirin therapy. His histopathological and ultrastructural findings from the liver biopsy were compatible with Reye's syndrome. He recovered completely, and there was no recurrence.
authors.affiliation: Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Chih-Ming
authors.initials: CM
authors.lastname: Wei
authors.forename: Huey-Ling
authors.initials: HL
authors.lastname: Chen
authors.forename: Ping-Ing
authors.initials: PI
authors.lastname: Lee
authors.forename: Chong-Ming
authors.initials: CM
authors.lastname: Chen
authors.forename: Chun-Yi
authors.initials: CY
authors.lastname: Ma
authors.forename: Wuh-Liang
authors.initials: WL
authors.lastname: Hwu
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications / Q000188:drug therapy*; D012202:Reye Syndrome / Q000209:etiology* / Q000503:physiopathology; D013624:Taiwan
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin