Trophic effect of enteral rehabilitative therapy in rat small bowel transplantation.
BACKGROUND
We aimed to observe the trophic effects on graft structure and recipient metabolism of enteral rehabilitative therapy in rat small bowel transplantation (SBT).


METHODS
Forty-eight recipients of rat allogeneic heterotopic SBT (Sprague-Dawley to Wistar rat) were divided into four groups randomly according to the presence of glutamine or growth hormone in the nutritional support regimen. We compared the histologic indices of graft mucosa and metabolic variables, including changes in body weight, nitrogen balance, urinary 3-methyl histidine excretion, and plasma albumin levels during 14 days after transplantation.


RESULTS
Glutamine and growth hormone promoted recovery of graft structure and improved recipient protein metabolism, as evidenced by indices of the enteral rehabilitative therapy.


CONCLUSIONS
Glutamine and growth hormone potentiated their effects in enteral rehabilitative therapy, which produced potent trophic effects on graft structure and recipient metabolism in rat SBT.
Zhang
X-Q
XQ
Department of General Surgery, General Hospital of Jinan Command, #25 Shifan Road, Jinan, Shandong, People's Republic of China.
Li
J-S
JS
Li
N
N
Li
Y-S
YS
Fan
X-H
XH
D000818:Animals; D004750:Enteral Nutrition; D007413:Intestinal Mucosa / Q000473:pathology; D007421:Intestine, Small / Q000637:transplantation*; D008871:Microvilli / Q000473:pathology; D009584:Nitrogen / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D012046:Rehabilitation; D014184:Transplantation, Homologous / Q000379:methods* / Q000473:pathology
D009584:Nitrogen