Serotonergic activity and the Beck Depression Inventory in the premenstrual syndrome.
OBJECTIVE
To investigate the relationship between platelet [3H]-imipramine binding and Beck Depression Inventory scores in the premenstrual syndrome (PMS).


METHODS
Thirty-one patients with PMS and 26 healthy female volunteers participated in the study. Imipramine binding was measured by saturation binding of [3H]-imipramine. The Beck Depression Inventory form was completed.


RESULTS
The number of [3H]-imipramine binding sites (Bmax) was significantly lower in the study group (p = 0.003). Beck Depression Scores were significantly higher in the study group as compared with the control group (p = 0.001). No correlation was found between platelet [3H]-imipramine binding and Beck Depression Inventory scores (r = 0.100, p = 0.591).


CONCLUSIONS
A significantly lower number of Bmax wasfound in patients with PMS as compared to controls, but no correlation between platelet [3H]-imipramine binding and Beck Depression Inventory scores was found.
Engin-Ustün
Yaprak
Y
Department of Gynecology and Obstetrics, Medical Faculty, Ankara University, Ankara, Turkey. ustunyus@yahoo.com
Ustün
Yusuf
Y
Gürdal
Hakan
H
Güngör
Mete
M
D000293:Adolescent; D018759:Adrenergic Uptake Inhibitors; D000328:Adult; D016022:Case-Control Studies; D003863:Depression / Q000145:classification* / Q000209:etiology*; D005260:Female; D006801:Humans; D007099:Imipramine; D008875:Middle Aged; D011293:Premenstrual Syndrome / Q000503:physiopathology* / Q000523:psychology*; D011569:Psychiatric Status Rating Scales; D011985:Receptors, Serotonin / Q000502:physiology; D012701:Serotonin / Q000502:physiology*; D012720:Severity of Illness Index
D018759:Adrenergic Uptake Inhibitors; D011985:Receptors, Serotonin; D012701:Serotonin; D007099:Imipramine