title: [Incidence and characteristics of intestinal hyperphosphatasemia in healthy subjects].
abstract: We recently reported that two intestinal alkaline phosphatase (IAP) isoforms, high molecular mass IAP (HIAP) and normal molecular mass IAP (NIAP), appear in healthy serum with our Triton-PAGE method for determination of ALP isozymes. In addition, HIAP is chiefly present in blood group B or O secretors, and a large amount of NIAP is secreted into the circulation in blood group B or O secretors. In the present paper, we examined incidences and characteristics of intestinal hyperphosphatasemia in healthy subjects and blood groups dependent hyperphosphatasemia. We classified 273 healthy women into two groups of blood group B or O secretors (n = 105) and other blood groups (n = 168). Intestinal hyperphosphatasemia in healthy subjects only appeared in sera of B or O blood group secretors, and incidence of intestinal hyperphosphatasemia was 26.6% (28/105). In addition, blood groups dependent hyperphosphatasemia, more than 350 U/l of ALP activity, was 21.4% (6/28) of intestinal hyperphosphatasemia in healthy subjects, and 5.7% (6/105) of blood group B or O secretors. These results suggested that blood groups dependent hyperphosphatasemia in healthy subjects was closely related to the HIAP and NIAP levels.
authors.affiliation: Department of Clinical Chemistry, Saitama Prefectural University, Koshigaya 343-8540.
authors.forename: Makoto
authors.initials: M
authors.lastname: Matsushita
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Irino
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Kamiyama
authors.forename: Tsugikazu
authors.initials: T
authors.lastname: Komoda
mesh_terms: D000017:ABO Blood-Group System; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood*; D005260:Female; D006801:Humans; D007421:Intestine, Small / Q000201:enzymology
chemical_list: D000017:ABO Blood-Group System; D000469:Alkaline Phosphatase