title: [Serum lactate dehydrogenase and its isoenzymes in nasopharyngeal carcinoma in Tunisia].
abstract: Our prospective study interested 41 patients, from 13 to 70 years old, and present a nasopharyngeal carcinoma confirmed histologically, during the period going from September 1999 to March 2000, and 45 healthy controls. A blood sample was collected from each patient before any treatment, as well as controls to measure serum LDH and its isoenzymes. Two groups of patients were selected after a period varying from 12 to 37 months with a mean of 29 months: 29 with favourable evolution, 12 with non favourable evolution. The mean serum total LDH and its isoenzymes values were significantly higher in patients than those in controls with values of variable p of 0.001 to 0.05. A significant correlation was found between ganglionnary extension and serum values of total LDH, LDH3 and LDH5. No significant difference were observed between the means serum total LDH before treatment and the clinical evolution of patients. Diagnostic contribution of total LDH is limited, by its ubiquitary character, but could constitute for LDH3 a good marker of the disease progression.
authors.affiliation: Service de Biologie Clinique, Institut Salah Azaïz, Tunis.
authors.forename: Aouatef
authors.initials: A
authors.lastname: Jmal
authors.forename: Monia
authors.initials: M
authors.lastname: Abdennebi
authors.forename: Hammouda
authors.initials: H
authors.lastname: Boussen
authors.forename: Hajer
authors.initials: H
authors.lastname: Abaza
authors.forename: Samia
authors.initials: S
authors.lastname: Gara
authors.forename: Katia
authors.initials: K
authors.lastname: Bendjemana
authors.forename: L
authors.initials: L
authors.lastname: Harzallah
authors.forename: F
authors.initials: F
authors.lastname: Guemira
authors.forename: A
authors.initials: A
authors.lastname: Ghanem
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D002277:Carcinoma / Q000201:enzymology*; D016022:Case-Control Studies; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000201:enzymology*; D011446:Prospective Studies; D014416:Tunisia
chemical_list: D014408:Biomarkers, Tumor; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase