Genomic sources of regulatory variation in cis and in trans.
Regulatory variation results from genetic changes with both cis and trans acting effects on gene expression. Here I describe the types of genetic variants that alter cis and trans regulation and discuss differences in the potential for cis and trans changes among different classes of genes. I argue that the molecular function of the protein encoded by each gene and how the gene is wired into the genomic regulatory network may influence its propensity for cis and trans regulatory changes.
Wittkopp
P J
PJ
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA. pw72@cornell.edu
D000818:Animals; D004742:Enhancer Elements, Genetic; D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D005809:Genes, Regulator; D014644:Genetic Variation; D006801:Humans; D009154:Mutation; D012045:Regulatory Sequences, Nucleic Acid