title: Cryptococcus neoformans Galactoxylomannan contains an epitope(s) that is cross-reactive with Aspergillus Galactomannan.
abstract: We report a case of cryptococcosis in which a serum enzyme-linked immunosorbent assay (ELISA) for Aspergillus galactomannan was positive, with no evidence of aspergillosis. Soluble antigens from 19 Cryptococcus neoformans strains and purified carbohydrates of C. neoformans capsule were thus assayed in the Aspergillus galactomannan ELISA. Antigens from all C. neoformans strains, and purified galactoxylomannan, gave a positive reaction, suggesting that C. neoformans galactoxylomannan contains an epitope(s) that is cross-reactive with Aspergillus galactomannan.
authors.affiliation: Laboratoire de Parasitologie Mycologie, Hôpital du Bocage, BP 77 908, 21079 Dijon Cedex, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Dalle
authors.forename: Pierre Emmanuel
authors.initials: PE
authors.lastname: Charles
authors.forename: Karine
authors.initials: K
authors.lastname: Blanc
authors.forename: Denis
authors.initials: D
authors.lastname: Caillot
authors.forename: Pascal
authors.initials: P
authors.lastname: Chavanet
authors.forename: Françoise
authors.initials: F
authors.lastname: Dromer
authors.forename: Alain
authors.initials: A
authors.lastname: Bonnin
mesh_terms: D000328:Adult; D001230:Aspergillus / Q000276:immunology* / Q000378:metabolism; D003429:Cross Reactions; D003453:Cryptococcosis / Q000276:immunology / Q000382:microbiology; D003455:Cryptococcus neoformans / Q000276:immunology* / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000737:chemistry / Q000276:immunology*; D005690:Galactose / Q000031:analogs & derivatives; D006801:Humans; D008297:Male; D008351:Mannans / Q000276:immunology*; D011134:Polysaccharides; D011135:Polysaccharides, Bacterial / Q000737:chemistry / Q000276:immunology*
chemical_list: D000939:Epitopes; D008351:Mannans; D011134:Polysaccharides; D011135:Polysaccharides, Bacterial; C012990:galactomannan; C043689:galactoxylomannan; D005690:Galactose