title: Pre-clinical diagnosis of Alzheimer disease combining platelet amyloid precursor protein ratio and rCBF spect analysis.
abstract: Platelet Amyloid Precursor Protein ratio of different abnormal forms and 99mTc-ECD SPECT perfusion analysis were evaluated in Mild Cognitive Impairment (MCI) subjects who progressed to Alzheimer Disease (AD) and in stable MCI. We report that their combined evaluation increases the discriminative power of the analysis in identifying presymptomatic AD. The positive predictive value of these combined markers in identifying progressive MCI was 0.87, and the negative predictive value was 0.90. This observation suggests that the interplay of different markers should be considered for enhancing diagnostic accuracy of pre-clinical AD.
authors.affiliation: Clinica Neurologica, Università degli Studi di Brescia, Pza Spedali Civili, 1, 25100 Brescia, Italy. bborroni@inwind.it
authors.forename: Barbara
authors.initials: B
authors.lastname: Borroni
authors.forename: Daniela
authors.initials: D
authors.lastname: Perani
authors.forename: Marcella
authors.initials: M
authors.lastname: Broli
authors.forename: Francesca
authors.initials: F
authors.lastname: Colciaghi
authors.forename: Valentina
authors.initials: V
authors.lastname: Garibotto
authors.forename: Barbara
authors.initials: B
authors.lastname: Paghera
authors.forename: Chiara
authors.initials: C
authors.lastname: Agosti
authors.forename: Raffaele
authors.initials: R
authors.lastname: Giubbini
authors.forename: Monica
authors.initials: M
authors.lastname: Di Luca
authors.forename: Alessandro
authors.initials: A
authors.lastname: Padovani
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D016564:Amyloid beta-Protein Precursor / Q000032:analysis* / Q000378:metabolism; D001792:Blood Platelets / Q000737:chemistry* / Q000473:pathology; D015153:Blotting, Western; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D016564:Amyloid beta-Protein Precursor