title: Synthesis of a laterally branched polyamine from alpha-methylene-gamma-butyrolactone.
abstract: [reaction: see text] A polyamine derivative was prepared from alpha-methylene-gamma-butyrolactone. This method used Michael addition and lactone aminolysis followed by the nucleophilic substitution of the hydroxyl group by an azido group. The coupling of a lipophilic alkyne led to a polyamine that will be probed as a gene transfer agent.
authors.affiliation: Faculté des Sciences Biologiques et Médicales, Institut de Chimie de Rennes, Synthèse et Extraction de Molécules à Visée Thérapeutique, Université de Rennes I, 2, Avenue du Professeur Léon Bernard, 35043 Rennes Cedex, France.
authors.forename: Mickaël
authors.initials: M
authors.lastname: Jean
authors.forename: Myriam
authors.initials: M
authors.lastname: Le Roch
authors.forename: Jacques
authors.initials: J
authors.lastname: Renault
authors.forename: Philippe
authors.initials: P
authors.lastname: Uriac
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D005663:Furans / Q000737:chemistry*; D015394:Molecular Structure; D011073:Polyamines / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D005663:Furans; D011073:Polyamines; C014096:alpha-methylene gamma-butyrolactone; D015107:4-Butyrolactone