Implementation of automated signal generation in pharmacovigilance using a knowledge-based approach.
Automated signal generation is a growing field in pharmacovigilance that relies on data mining of huge spontaneous reporting systems for detecting unknown adverse drug reactions (ADR). Previous implementations of quantitative techniques did not take into account issues related to the medical dictionary for regulatory activities (MedDRA) terminology used for coding ADRs. MedDRA is a first generation terminology lacking formal definitions; grouping of similar medical conditions is not accurate due to taxonomic limitations. Our objective was to build a data-mining tool that improves signal detection algorithms by performing terminological reasoning on MedDRA codes described with the DAML+OIL description logic. We propose the PharmaMiner tool that implements quantitative techniques based on underlying statistical and bayesian models. It is a JAVA application displaying results in tabular format and performing terminological reasoning with the Racer inference engine. The mean frequency of drug-adverse effect associations in the French database was 2.66. Subsumption reasoning based on MedDRA taxonomical hierarchy produced a mean number of occurrence of 2.92 versus 3.63 (p < 0.001) obtained with a combined technique using subsumption and approximate matching reasoning based on the ontological structure. Semantic integration of terminological systems with data mining methods is a promising technique for improving machine learning in medical databases.
Bousquet
Cédric
C
INSERM U729, Faculté de médecine Broussais Hôtel Dieu, 15 rue de l'Ecole de Médecine, 75006 Paris, France. cedric.bousquet@spim.jussieu.fr
Henegar
Corneliu
C
Louët
Agnès Lillo-Le
AL
Degoulet
Patrice
P
Jaulent
Marie-Christine
MC
D016907:Adverse Drug Reaction Reporting Systems / Q000458:organization & administration* / Q000592:standards; D000465:Algorithms; D016208:Databases, Factual; D004018:Dictionaries, Medical as Topic; D001330:Electronic Data Processing / Q000379:methods*; D005602:France; D012984:Software; D009626:Terminology as Topic