The effect of magnesium sulfate treatment on serum cardiac troponin I levels in preeclamptic women.
OBJECTIVE
To investigate serum cardiac troponin I levels before and after magnesium sulfate treatment in preeclamptic pregnant women.


METHODS
Fifty-five pregnant women were included in the prospectively planned study. Study group patients (n = 25) were pregnant women hospitalized with a preeclampsia diagnosis while the control group (n = 30) were pregnant women with no medical or obstetric problem who had been attending the antenatal clinic. Serum cardiac troponin I levels were compared in the normal pregnant women and in preeclamptic pregnant women. These levels were also compared in the preeclamptic women before and after magnesium sulfate treatment. Mann-Whitney U-test was used for statistical analysis.


RESULTS
Groups were similar with respect to age, gravity, parity, and gestational age. The median serum cardiac troponin I levels in preeclamptic patients was 0.20 ng/ml (0.02-4.53) before treatment and 0.09 ng/ml (0.02-3.91) after treatment, while it was 0.02 ng/ml (0.0-0.05) in the control group. The serum cardiac troponin I level in the preeclamptic group was significantly high (P < 0.01), and pretreatment values in this group were significantly higher compared with post-treatment values (P < 0.01)


CONCLUSIONS
Cardiac troponin I is a sensitive parameter for indicating minor myocardial damage which may occur in preeclampsia and for evaluating the efficiency of magnesium sulfate treatment.
Atalay
Cemal
C
Gynecology and Obstetric Department of Ankara Numune Education and Research Hospital, Ankara, Turkey. cfatalay@superonline.com
Erden
Gönül
G
Turhan
Turan
T
Yildiran
Gülbin
G
Saraçoglu
O Ferit
OF
Koca
Yüksel
Y
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008278:Magnesium Sulfate / Q000627:therapeutic use*; D011225:Pre-Eclampsia / Q000097:blood* / Q000188:drug therapy*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood*; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D015149:Tocolytic Agents / Q000627:therapeutic use*; D019210:Troponin I / Q000097:blood*
D015149:Tocolytic Agents; D019210:Troponin I; D008278:Magnesium Sulfate