title: Assessment of lung microstructure with magnetic resonance imaging of hyperpolarized Helium-3.
abstract: Magnetic resonance imaging of the apparent diffusion coefficient (ADC) of hyperpolarized Helium-3 is a new technique for probing pulmonary microstructure in vivo. The aim of this study was the assessment of potential sources of systematic errors of the ADC measurement. The influence of macroscopic motion was determined by measurements at two different delays after initiating the breath-hold, and before and after cardiac arrest. An intercentre comparison was performed in two age- and lung function-matched groups of lung-healthy volunteers at two research sites. Moreover, measurements of diffusion anisotropy were performed. We found no dependency of the ADC as a function of the delay after stop of inspiration. The influence of cardiac motion was less than 10%. In the intercentre comparison study, an excellent agreement between the two sites was found. First measurements of the diffusion tensor of intrapulmonary Helium-3 are shown.
authors.affiliation: Department of Diagnostic and Interventional Radiology, Johannes Gutenberg-University Medical School, Langenbeckstr. 1, 55131 Mainz, Germany. wschreib@uni-mainz.de
authors.forename: Wolfgang G
authors.initials: WG
authors.lastname: Schreiber
authors.forename: Andreas E
authors.initials: AE
authors.lastname: Morbach
authors.forename: Trine
authors.initials: T
authors.lastname: Stavngaard
authors.forename: Klaus K
authors.initials: KK
authors.lastname: Gast
authors.forename: Anette
authors.initials: A
authors.lastname: Herweling
authors.forename: Lise Vejby
authors.initials: LV
authors.lastname: Søgaard
authors.forename: Michael
authors.initials: M
authors.lastname: Windirsch
authors.forename: Jörg
authors.initials: J
authors.lastname: Schmiedeskamp
authors.forename: Claus Peter
authors.initials: CP
authors.lastname: Heussel
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Kauczor
mesh_terms: D000818:Animals; D016880:Anisotropy; D001944:Breath Tests / Q000379:methods; D016022:Case-Control Studies; D038524:Diffusion Magnetic Resonance Imaging; D006323:Heart Arrest / Q000175:diagnosis* / Q000503:physiopathology; D006371:Helium / Q000378:metabolism*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007554:Isotopes / Q000378:metabolism; D008168:Lung / Q000473:pathology / Q000503:physiopathology*; D008875:Middle Aged; D013552:Swine; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D007554:Isotopes; D006371:Helium