Relaxin adenylyl cyclase system of pregnant women with diabetes: functional defects in insulin and relaxin adenylyl cyclase signaling systems in myometrium of pregnant women with type 1 diabetes.
The study was conducted to reveal the functional disturbances in two novel insulin and relaxin adenylyl cyclase signaling mechanisms (ACSMs). It was shown for the first time that in myometrium of pregnant women with insulin insufficiency the functional defects of Gs-protein-AC coupling in insulin- and relaxin H2-regulated AC systems were developed. As a result, the sensitivity of the signaling systems to both hormones and potentiation of their AC effects by guanine nucleotides were markedly decreased compared with that in control group. These functional defects in ACSM may lead to violation of the process of insulin and relaxin signal transduction.
Kuznetsova
Ludmila
L
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Thorez pr. 44, St. Petersburg, 194223, Russia.
Plesneva
Svetlana
S
Shpakov
Alexander
A
Pertseva
Marianna
M
D000262:Adenylyl Cyclases / Q000378:metabolism*; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000201:enzymology / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007328:Insulin / Q000494:pharmacology*; D009215:Myometrium / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism*; D011247:Pregnancy; D012065:Relaxin / Q000494:pharmacology*; D015398:Signal Transduction
D007328:Insulin; D012065:Relaxin; D000262:Adenylyl Cyclases