title: Separation of naproxen enantiomers by supercritical/subcritical fluid chromatography.
abstract: An isocratic supercritical/subcritical fluid chromatography method for the separation of naproxen enantiomers on the Kromasil CHI-TBB column was investigated. The mobile phase was composed of supercritical CO2 with 2-propanol as modifier. The experimental conditions were temperature 293 K-323 K, pressure 9.4 MPa-21.3 MPa, and 2-propanol concentration 6%-15% (by mass), respectively. The enthalpic contribution to the overall enantiomer transfer energy was more important than the entropic contribution in the temperature range examined. The preferred operation conditions were 293 K, 9.4 MPa, and the concentration of 2-propanol in the mobile phase 11% (by mass).
authors.affiliation: Institute of Pharmaceutical Engineering, Department of Chemical and Biochemical Engineering, Zhejiang University, 38 Zheda Road, Hangzhou 310027, China. ceywyang@zju.edu.cn
authors.forename: Yiwen
authors.initials: Y
authors.lastname: Yang
authors.forename: Baogen
authors.initials: B
authors.lastname: Su
authors.forename: Quanhong
authors.initials: Q
authors.lastname: Yan
authors.forename: Qilong
authors.initials: Q
authors.lastname: Ren
mesh_terms: D019840:2-Propanol / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification; D002245:Carbon Dioxide / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002845:Chromatography / Q000379:methods*; D004345:Drug Industry / Q000379:methods; D009288:Naproxen / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification; D011312:Pressure; D013237:Stereoisomerism; D013678:Technology, Pharmaceutical / Q000379:methods; D013696:Temperature; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002245:Carbon Dioxide; D009288:Naproxen; D019840:2-Propanol