title: The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig.
abstract: Transthyretin (TTR) is a serum protein which is a negative acute phase reactant in humans and levels of TTR are routinely measured as an indicator of health status. Such tests have yet to be established for the pig. In order to measure serum TTR in the pig during an acute phase response an assay was developed using anti-human TTR antibodies which cross reacted with porcine TTR. The assay had a detection limit of 32 microg/mL while the mean concentration of transthyretin measured in healthy pig serum was 302 +/- 8 microg/mL (n = 63). There was no significant difference in the serum concentration of TTR in three different age groups from 10 to 25 weeks. Following Streptococcus suis type 2 infection transthyretin showed a negative acute phase response with serum concentrations reaching a significantly lower level at two days following infection.
authors.affiliation: Institute of Comparative Medicine, Division of Animal Production and Public Health, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, G61 1QH Glasgow, Scotland, UK.
authors.forename: Fiona M
authors.initials: FM
authors.lastname: Campbell
authors.forename: Mary
authors.initials: M
authors.lastname: Waterston
authors.forename: Lars Ole
authors.initials: LO
authors.lastname: Andresen
authors.forename: Nanna Skall
authors.initials: NS
authors.lastname: Sorensen
authors.forename: Peter Mikael H
authors.initials: PM
authors.lastname: Heegaard
authors.forename: P David
authors.initials: PD
authors.lastname: Eckersall
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers / Q000097:blood; D007118:Immunoassay / Q000379:methods / Q000662:veterinary; D011228:Prealbumin / Q000378:metabolism*; D012680:Sensitivity and Specificity; D013290:Streptococcal Infections / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D017011:Streptococcus suis; D013552:Swine; D013553:Swine Diseases / Q000097:blood / Q000175:diagnosis*
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; D011228:Prealbumin