title: Developmental impact of leukemic fusion genes on stem cell fate.
abstract: Stem and progenitor cells present attractive targets for transformation by leukemia-associated fusion genes generated by chromosomal translocation. The mechanism by which these fusion genes corrupt the transcriptional programs of these cellular compartments remains largely unknown. We have sought to gain insight into these issues through expressing TEL-AML1 and TEL-TRKC fusion genes in murine stem cells and recording effects on cell behavior in a transplant setting.
authors.affiliation: Molecular Haematology Unit, The Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK. tenver@gwmail.jr2.ox.ac.uk
authors.forename: Tariq
authors.initials: T
authors.lastname: Enver
authors.forename: Shinobu
authors.initials: S
authors.lastname: Tsuzuki
authors.forename: John
authors.initials: J
authors.lastname: Brown
authors.forename: Dengli
authors.initials: D
authors.lastname: Hong
authors.forename: Rajeev
authors.initials: R
authors.lastname: Gupta
authors.forename: Tony
authors.initials: T
authors.lastname: Ford
authors.forename: Minenori-Ishimae
authors.initials: MI
authors.lastname: Egucchi
authors.forename: Mariko
authors.initials: M
authors.lastname: Egucchi
authors.forename: Mel
authors.initials: M
authors.lastname: Greaves
mesh_terms: D000818:Animals; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D007938:Leukemia / Q000209:etiology / Q000235:genetics / Q000473:pathology; D051379:Mice; D008954:Models, Biological; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D033581:Stem Cell Transplantation; D014178:Translocation, Genetic
chemical_list: D015514:Oncogene Proteins, Fusion