title: Neurocognitive impairment does not predict treatment outcome in obsessive-compulsive disorder.
abstract: There is conflicting evidence pertaining to whether or not neurocognitive task performance at baseline predicts treatment response in obsessive-compulsive disorder (OCD). In the present study, we administered a set of executive neurocognitive tests with a putative sensitivity for treatment outcome to a sample of 138 OCD patients. Additionally, subjective neurocognitive dysfunction was determined via a questionnaire. All patients participated in a cognitive-behavioural treatment program (CBT). Results showed that responders (n = 73) did not differ from non-responders (n = 65) on any of the parameters except for decreased performance on the delayed alternation test (p < .1, effect size: .61). A subsidiary analysis revealed that slowing on the Trail-Making Test A and an enhanced rate of perserveration errors on the Wisconsin Card Sorting Test predicted poor outcome for the treatment of compulsions. It is concluded that neurocognitive impairment does not represent a reliable early warning sign for non-response to CBT.
authors.affiliation: Universitätsklinikum Hamburg-Eppendorf, Klinik für Psychiatrie und Psychotherapie, Hamburg, Germany. moritz@uke.uni-hamburg.de
authors.forename: Steffen
authors.initials: S
authors.lastname: Moritz
authors.forename: Martin
authors.initials: M
authors.lastname: Kloss
authors.forename: Dirk
authors.initials: D
authors.lastname: Jacobsen
authors.forename: Susanne
authors.initials: S
authors.lastname: Fricke
authors.forename: Carrie
authors.initials: C
authors.lastname: Cutler
authors.forename: Stefanie
authors.initials: S
authors.lastname: Brassen
authors.forename: Iver
authors.initials: I
authors.lastname: Hand
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000523:psychology*; D015928:Cognitive Behavioral Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000523:psychology* / Q000628:therapy*; D011379:Prognosis; D016896:Treatment Outcome