[Relationship between LAPTM4B gene polymorphism and susceptibility of lung cancer].
OBJECTIVE
To investigate the possible association between the allelic variation of LAPTM4B and the genetic susceptibility of lung cancer.


METHODS
The genotype of LAPTM4B was analyzed in 134 unrelated healthy adult individuals and 166 patients with lung cancer by utilizing polymerase chain reaction based on special primers. The genotypical distribution of LAPTM4B was analyzed by chi2 test.


RESULTS
The allelic frequencies of the *2 were 40.1% and 28.0% in the lung cancer group and the healthy control group respectively, which was significantly different between the two groups (P=0.002). There was a significant difference in the overall genotypical distribution between the patients and the controls (P=0.005). The risk of suffering from lung cancer was increased 1.91 times in the individuals of the *1/2 genotype (95%CI: 1.178-3.110) and 3.26 times in the individuals of the *2/2 genotype of LAPTM4B (95%CI: 1.338-7.929) compared with the *1/2 genotype. No association was observed between the genotypical distribution of LAPTM4B and the clinical information on patients of lung cancer such as gender, age, pathological type, differentiation classification of TNM and infection of HBV.


CONCLUSIONS
This study suggests that the allele *2 of LAPTM4B might be the risk factor of lung cancer, which could be associated with genetic susceptibility of lung cancer.
Deng
Li-juan
LJ
Department of Immunology, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100036, China.
Zhang
Qing-yun
QY
Liu
Bo
B
Zhou
Rou-li
RL
D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism; D000328:Adult; D000368:Aged; D000483:Alleles; D001483:Base Sequence; D018288:Carcinoma, Small Cell / Q000235:genetics / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D008969:Molecular Sequence Data; D015513:Oncogene Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic
C477083:LAPTM4B protein, human; D008565:Membrane Proteins; D015513:Oncogene Proteins