title: International Salmonella Typhimurium DT104 infections, 1992-2001.
abstract: The incidence of multidrug-resistant (MDR) Salmonella Typhimurium infections in humans, and in particular MDR definitive phage type 104 (DT104), has increased substantially in many countries in the last 2 decades, often associated with increased illness. To examine the magnitude of this problem, a survey was conducted among countries with available antimicrobial resistance or phage typing surveillance data. A total of 29, primarily industrialized, countries participated in the survey, which covered the years 1992-2001. Overall, the incidence of MDR S. Typhimurium and DT104 increased continuously during this period, although the problem affected primarily Europe and North America. The increase appeared to have peaked in the United Kingdom but not in other countries. Also, the incidence of quinolone-resistant S. Typhimurium was increasing. This survey implies that MDR S. Typhimurium constitutes an increasing public health problem in large parts of the world and emphasizes the importance of surveillance and control programs.
authors.affiliation: Statens Serum Institut, Copenhagen, Denmark. mhe@ssi.dk
authors.forename: Morten
authors.initials: M
authors.lastname: Helms
authors.forename: Steen
authors.initials: S
authors.lastname: Ethelberg
authors.forename: Kåre
authors.initials: K
authors.lastname: Mølbak
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001434:Bacteriophage Typing; D019049:Developed Countries; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D011159:Population Surveillance; D012480:Salmonella Infections / Q000453:epidemiology* / Q000382:microbiology; D012486:Salmonella typhimurium / Q000145:classification* / Q000187:drug effects* / Q000821:virology; D012703:Serotyping; D011795:Surveys and Questionnaires
chemical_list: D000900:Anti-Bacterial Agents