title: Structure-activity relationships of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists.
abstract: SAR studies of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists resulted in potent compounds. The best compound from the series had a binding affinity of 2 nM.
authors.affiliation: Department of Medicinal Chemistry, Neurocrine Biosciences, Inc., 12790 El Camino Real, San Diego, CA 92130, USA. zguo@neurocrine.com
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Guo
authors.forename: Dongpei
authors.initials: D
authors.lastname: Wu
authors.forename: Yun-Fei
authors.initials: YF
authors.lastname: Zhu
authors.forename: Fabio C
authors.initials: FC
authors.lastname: Tucci
authors.forename: Collin F
authors.initials: CF
authors.lastname: Regan
authors.forename: Martin W
authors.initials: MW
authors.lastname: Rowbottom
authors.forename: R Scott
authors.initials: RS
authors.lastname: Struthers
authors.forename: Qiu
authors.initials: Q
authors.lastname: Xie
authors.forename: Shelby
authors.initials: S
authors.lastname: Reijmers
authors.forename: Susan K
authors.initials: SK
authors.lastname: Sullivan
authors.forename: Yang
authors.initials: Y
authors.lastname: Sai
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
mesh_terms: D004353:Drug Evaluation, Preclinical; D006801:Humans; D015394:Molecular Structure; D011966:Receptors, LHRH / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D014227:Triazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D011966:Receptors, LHRH; D014227:Triazines