title: Synthesis and biological evaluation of quinoxaline-5,8-diones that inhibit vascular smooth muscle cell proliferation.
abstract: A series of 6-arylamino-2,3-bis(pyridin-2-yl)-7-chloro-quinoxaline-5,8-diones were synthesized and evaluated for their inhibitory activity on the rat aortic smooth muscle cell (RAoSMC) proliferation. The quinoxaline-5,8-diones exhibited a potent antiproliferative activity. Further mechanistic study revealed that the inhibitory effect of one representative quinoxaline-5,8-dione on SMC proliferation was mediated by modulation of the extracellular signal-regulated kinase 1/2 signaling pathway in the RAoSMCs.
authors.affiliation: College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, Republic of Korea.
authors.forename: Hwa-Jin
authors.initials: HJ
authors.lastname: Chung
authors.forename: Ok-Jai
authors.initials: OJ
authors.lastname: Jung
authors.forename: Mi Jin
authors.initials: MJ
authors.lastname: Chae
authors.forename: Sung-Yu
authors.initials: SY
authors.lastname: Hong
authors.forename: Kwang-Hoe
authors.initials: KH
authors.lastname: Chung
authors.forename: Sang Kook
authors.initials: SK
authors.lastname: Lee
authors.forename: Chung-Kyu
authors.initials: CK
authors.lastname: Ryu
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects*; D015195:Drug Design; D006131:Growth Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D015398:Signal Transduction / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D006131:Growth Inhibitors; D011810:Quinoxalines