title: Long-term vitreous replacement with perfluorohexyloctane and silicone oil: preliminary reports of a multicentric study.
abstract: OBJECTIVE
  To report on the use of a combined intra-ocular tamponade with silicone oil and perfluorohexyloctane (F(6)H(8)) in the treatment of complex retinal detachment.
  
  
  METHODS
  A prospective consecutive interventional case series from seven study centres.
  
  
  METHODS
  69 patients presenting a retinal detachment with proliferative vitreoretinopathy (PVR) and retinal breaks of the inferior two quadrants of the fundus.
  
  
  METHODS
  Patients were divided into two groups: (1) 28 eyes which had not been operated on before; (2) 41 eyes affected by recurrent retinal detachment that had had unsuccessful previous surgery with silicone oil or gas tamponade. A pars plana vitrectomy, membrane peeling and -- when necessary -- a retinotomy were performed; the vitreous cavity was filled with two thirds of F(6)H(8) and one third of silicone oil 1,000 mPas (double filling, DF). The endotamponade was removed after 30-45 days (median 38) and replaced by balanced salt solution or silicone oil according to the condition of the retina.
  
  
  RESULTS
  Retinal reattachment was achieved in 52 out of 69 cases (75%) 6 months after removal of the DF without any endotamponade.
  
  
  CONCLUSIONS
  The DF with F(6)H(8) and silicone oil allows a good endotamponading to the inferior retina and the posterior pole. The DF appeared to be well tolerated. Further studies are necessary to evaluate whether a DF is advantageous in respect to silicone oil filling alone in case of retinal breaks and PVR of the inferior retina.
authors.affiliation: Ospedale Santa Chiara, Pisa, Italy. chiroftalmica@ao-pisa.toscana.it
authors.forename: Stanislao
authors.initials: S
authors.lastname: Rizzo
authors.forename: Federica
authors.initials: F
authors.lastname: Genovesi-Ebert
authors.forename: Claudia
authors.initials: C
authors.lastname: Belting
authors.forename: Flavio
authors.initials: F
authors.lastname: Foltran
authors.forename: Enrico
authors.initials: E
authors.lastname: Gandolfo
authors.forename: Guido
authors.initials: G
authors.lastname: Lesnoni
authors.forename: Ermanno
authors.initials: E
authors.lastname: Dell'omo
authors.forename: Stefano
authors.initials: S
authors.lastname: Zenoni
authors.forename: Marco
authors.initials: M
authors.lastname: Azzolini
authors.forename: Vito
authors.initials: V
authors.lastname: De Molfetta
mesh_terms: D000328:Adult; D000368:Aged; D004359:Drug Therapy, Combination; D005260:Female; D005466:Fluorocarbons / Q000008:administration & dosage*; D006801:Humans; D007431:Intraoperative Complications; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D012163:Retinal Detachment / Q000601:surgery*; D012167:Retinal Perforations / Q000601:surgery; D012827:Silicone Oils / Q000008:administration & dosage*; D014792:Visual Acuity; D014821:Vitrectomy / Q000379:methods*; D018630:Vitreoretinopathy, Proliferative / Q000601:surgery; D014822:Vitreous Body / Q000187:drug effects*
chemical_list: D005466:Fluorocarbons; D012827:Silicone Oils; C118616:perfluorohexyl-octan