title: Ophthalmologic and neurologic findings in two children exposed to vigabatrin in utero.
abstract: Vigabatrin (VGB) is an important treatment option for infantile spasms. Vigabatrin-induced visual field defects are at present the most important safety issue in the use of the drug. The knowledge concerning VGB-associated visual dysfunction in pediatric patients, particularly in those who have been exposed to VGB in utero is limited. We explored ophthalmic and neurologic findings in two children who have been exposed prenatally to VGB.
authors.affiliation: Department of Ophthalmology, Kuopio University Hospital, P.O. Box 1777, FIN-70211 Kupio, Finland. iiris.sorri@uku.fi
authors.forename: Iiris
authors.initials: I
authors.lastname: Sorri
authors.forename: Eila
authors.initials: E
authors.lastname: Herrgård
authors.forename: Katriina
authors.initials: K
authors.lastname: Viinikainen
authors.forename: Ari
authors.initials: A
authors.lastname: Pääkkönen
authors.forename: Seppo
authors.initials: S
authors.lastname: Heinonen
authors.forename: Reetta
authors.initials: R
authors.lastname: Kälviäinen
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D002648:Child; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D009460:Neurologic Examination / Q000379:methods; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011930:Reaction Time / Q000187:drug effects; D014599:Uterus / Q000187:drug effects; D020888:Vigabatrin / Q000009:adverse effects*; D014786:Vision Disorders / Q000209:etiology*; D014792:Visual Acuity / Q000187:drug effects; D014794:Visual Fields / Q000187:drug effects
chemical_list: D000927:Anticonvulsants; D020888:Vigabatrin