Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine.
Caffeine, a component of tea, coffee and cola, induces wakefulness. It binds to adenosine A1 and A2A receptors as an antagonist, but the receptor subtype mediating caffeine-induced wakefulness remains unclear. Here we report that caffeine at 5, 10 and 15 mg kg(-1) increased wakefulness in both wild-type mice and A1 receptor knockout mice, but not in A2A receptor knockout mice. Thus, caffeine-induced wakefulness depends on adenosine A2A receptors.
Huang
Zhi-Li
ZL
Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka 565-0874, Japan.
Qu
Wei-Min
WM
Eguchi
Naomi
N
Chen
Jiang-Fan
JF
Schwarzschild
Michael A
MA
Fredholm
Bertil B
BB
Urade
Yoshihiro
Y
Hayaishi
Osamu
O
D000818:Animals; D001143:Arousal / Q000187:drug effects* / Q000502:physiology*; D002110:Caffeine / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D051379:Mice; D018345:Mice, Knockout; D043705:Receptor, Adenosine A2A / Q000502:physiology*; D014851:Wakefulness / Q000187:drug effects / Q000502:physiology
D000697:Central Nervous System Stimulants; D043705:Receptor, Adenosine A2A; D002110:Caffeine