title: [Necrotizing fasciitis].
abstract: An experience with treatment of four patients with necrotizing fasciitis (NF) and a review of literature were used to characterize this rare but dangerous for life disease, The pathogen of NF is a hemolytic group A streptococcus and anaerobes. The mechanism of the development of fasciitis is based on impairments in the microcirculatory bed due to the action on the cytokine endothelium. Rapidly progressing necrosis of fasciae results in a number of complications. The treatment consists of the early and aggressive necrectomy and intensive antibiotic therapy in combination with immunomodulation.
authors.forename: M V
authors.initials: MV
authors.lastname: Grinev
authors.forename: O A
authors.initials: OA
authors.lastname: Bud'ko
authors.forename: K M
authors.initials: KM
authors.lastname: Grinev
authors.forename: O V
authors.initials: OV
authors.lastname: Babkov
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D003937:Diagnosis, Differential; D018450:Disease Progression; D019115:Fasciitis, Necrotizing / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000401:mortality / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D012772:Shock, Septic / Q000209:etiology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents