title: Granulocyte-colony stimulating factor producing urothelial carcinoma of renal pelvis.
abstract: We report a case of granulocyte-colony stimulating factor (G-CSF) producing urothelial carcinoma of the renal pelvis in a 39-year old man. The patient was admitted to Kobe University Hospital, Kobe, Japan, complaining of macrohematuria and a 6-month history of left abdominal swelling. Abdominal computed tomography showed a large mass in the left kidney and para-aortic lymph node enlargement. A remarkable degree of leukocytosis was detected without any acute infectious disease. Enzyme immunoassay of the serum demonstrated a remarkable high concentration of G-CSF. The patient underwent left nephroureterectomy and para-aortic lymphadenectomy. Histochemical examination revealed urothelial carcinoma. Immunohistochemical staining with an anti-G-CSF antibody demonstrated G-CSF secreting cells. The patient died 8 weeks after the surgical operation. To our knowledge, this is the second case of G-CSF producing urothelial carcinoma of renal pelvis reported in the English literature.
authors.affiliation: Division of Urology, Department of Organs Therapeutics, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan. terao@med.kobe-u.ac.jp
authors.forename: Shuji
authors.initials: S
authors.lastname: Terao
authors.forename: Yuji
authors.initials: Y
authors.lastname: Yamada
authors.forename: Toshiro
authors.initials: T
authors.lastname: Shirakawa
authors.forename: Isao
authors.initials: I
authors.lastname: Hara
authors.forename: Naoki
authors.initials: N
authors.lastname: Kanomata
authors.forename: Sadao
authors.initials: S
authors.lastname: Kamidono
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D007682:Kidney Pelvis; D008297:Male; D009392:Nephrectomy; D014057:Tomography, X-Ray Computed; D014567:Urography
chemical_list: D014408:Biomarkers, Tumor; D016179:Granulocyte Colony-Stimulating Factor