title: Comparison of quality of life outcomes in laryngeal cancer patients following chemoradiation vs. total laryngectomy.
abstract: OBJECTIVE
  To evaluate quality of life issues in patients with laryngeal cancer after treatment with either chemoradiation or total laryngectomy and radiation therapy.
  
  
  METHODS
  Forty-nine patients with a history of stage II-IV laryngeal squamous cell carcinoma treated primarily with either chemoradiation or by total laryngectomy with postoperative radiation completed the University of Washington Quality of Life instrument, version 4. Patients were identified on a volunteer basis in an academic university head and neck clinic setting. Each patient completed the above instrument, and statistical analysis was performed by Wilcoxon and chi 2 tests.
  
  
  RESULTS
  Instruments were completed by all 49 patients: 15 patients who underwent primary chemoradiation and 34 patients who underwent a total laryngectomy followed by radiation. Domains reported in both treatment groups without significant differences were appearance, activity, recreation, moods, taste, saliva, anxiety, and general questions. However, there were significant differences between the 2 groups in the domains of pain, swallowing, chewing, speech, and shoulder function. The laryngectomy patients reported greater impairment of speech (P = 0.001), and shoulder function (P = 0.018), whereas the chemoradiation patients suffered from greater pain, difficulty swallowing (P = 0.061), and problems chewing (P = 0.027).
  
  
  CONCLUSIONS
  Most patients with laryngeal cancer, whether treated primarily with chemoradiation or total laryngectomy, reported excellent functional outcomes and health-related quality of life. Pain, swallowing, chewing, saliva, and shoulder function were recorded as significant factors affecting their daily quality of life.
authors.affiliation: Division of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1624, USA.
authors.forename: Maria M
authors.initials: MM
authors.lastname: LoTempio
authors.forename: Kevin H
authors.initials: KH
authors.lastname: Wang
authors.forename: Ahmed
authors.initials: A
authors.lastname: Sadeghi
authors.forename: Mark D
authors.initials: MD
authors.lastname: Delacure
authors.forename: Guy F
authors.initials: GF
authors.lastname: Juillard
authors.forename: Marilene B
authors.initials: MB
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D003680:Deglutition Disorders / Q000209:etiology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012189:Retrospective Studies; D013064:Speech Disorders / Q000209:etiology; D016896:Treatment Outcome