title: Metabolic response to oral lipid overload in diabetes and impaired glucose tolerance.
abstract: Post-prandial hyperglycemia and hypertriglyceridemia have been related to atherogenesis. The aim of this study was to evaluate the response of plasma lipoproteins to a lipid overload in subjects with diabetes (DM), impaired glucose tolerance (IGT) and normals (N). Seventy-seven subjects were selected, 36-85 years, plasma glucose (G)<140 mg/dl and triglycerides (TG)<150 mg/dl; those without diabetes underwent a glucose tolerance test (GTT), which classified them into three groups: N, 2h G<140 mg/dl, n=37; IGT, 2h G 140-200mg/dl, n=20; and DM, previous diabetes or 2h G>200mg/dl, n=20. They were submitted to a clinical evaluation and an oral lipid overload (1000 kcal, 58% fat). Fasting, 4 and 6-h blood samples after the meal were collected for G, insulinaemia (I), TG, cholesterol and their fractions, and HOMA-IR. Fasting and post-lipid overload lipoproteins were similar between groups, but 6h TG was still high in DM versus IGT and N as compared to their 4h values. There was a positive correlation between fasting TG versus 6h TG (r=0.78, p<0.001). We conclude that individuals with impaired glucose tolerance and with diabetes mellitus have a slower plasma reduction of triglycerides after lipid overload, as well as an altered glucose and post-prandial insulin response.
authors.affiliation: Serviço de Epidemiologia da Unidade de Pesquisa do Instituto de Cardiologia do RS/FUC (Fundação Universitária de Cardiologia), Av. Princesa Isabel, 370-Santana-Porto Alegre, RS, Brazil.
authors.forename: Maria Teresa O
authors.initials: MT
authors.lastname: de Ugarte
authors.forename: Vera Lúcia
authors.initials: VL
authors.lastname: Portal
authors.forename: Ana Amélia
authors.initials: AA
authors.lastname: Dias
authors.forename: Beatriz D'Agord
authors.initials: BD
authors.lastname: Schaan
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D015992:Body Mass Index; D003920:Diabetes Mellitus / Q000097:blood / Q000378:metabolism*; D004041:Dietary Fats / Q000494:pharmacology*; D018149:Glucose Intolerance / Q000097:blood / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D008875:Middle Aged; D012016:Reference Values; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D007328:Insulin; D014280:Triglycerides