A drug dosage table is a useful tool to facilitate prescriptions of antiretroviral drugs for children in Thailand.
Scaling up of antiretroviral treatment (ART) for children in countries like Thailand will require decentralization and management by non-specialist doctors. We describe (a) the formulation of a standardized drug dosage table to facilitate antiretroviral drug (ARV) prescriptions for children, (b) the acceptability of such a table among doctors and (c) the safety and efficacy of drug doses in the table. Acceptability was assessed using a questionnaire. Safety and efficacy were assessed on the basis of incidence of adverse effects and virological response to treatment, respectively. Of all doctors (n=18), 17 (94%) found that the table was practical to use, avoided miscalculations and made them more confident with prescriptions. Of 49 children prescribed ARVs, less than 5% had adverse side-effects. All ARV-naïve children achieved undetectable viral loads within six months of ART. In our setting, a standardized drug dosage table provided a simple and reliable tool that facilitated ARV prescriptions for children.
Ponnet
M
M
Médecins Sans Frontières, Bangkok, Thailand.
Frederix
K
K
Petdachai
W
W
Wilson
D
D
Eksaengsri
A
A
Zachariah
R
R
D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D004347:Drug Interactions; D016903:Drug Monitoring; D011307:Drug Prescriptions; D015658:HIV Infections / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D013785:Thailand
D019380:Anti-HIV Agents