title: MR diffusion tensor imaging and fiber tracking in spinal cord compression.
abstract: OBJECTIVE
  Spinal cord damage can result in major functional disability. Alteration of the spinal cord structural integrity can be assessed by using diffusion tensor imaging methods. Our objective is to evaluate the diagnostic accuracy of apparent diffusion coefficient (ADC), fractional anisotropy (FA), and fiber tracking in both acute and slowly progressive spinal cord compressions.
  
  
  METHODS
  Fifteen patients with clinical symptoms of acute (n = 2) or slowly progressive (n = 13) spinal cord compression and 11 healthy volunteers were prospectively selected. We performed T2-weighted fast spin echo (FSE) and diffusion tensor imaging by using a 1.5-T MR scanner. ADC and FA maps were computed. Regions of interest were placed at the cervical, upper and lower thoracic cord levels for the healthy subjects and on the area with abnormal T2-weighted signal intensity in the patients with cord compression. In three patients, we used fiber tracking to locate the areas of cord compression precisely. Data were analyzed by using a mixed model. The sensitivity (SE) and specificity (sp) of imaging (T2, ADC, and FA maps) in the detection of spinal cord abnormality were statistically evaluated.
  
  
  RESULTS
  For the healthy subjects, averaged ADC values ranged from 0.96 10(-3) mm(2)/s to 1.05 10(-3) mm(2)/s and averaged FA values ranged from 0.745 to 0.751. Ten patients had decreased FA (0.67 +/- 0.087), and one had increased FA values (0.831); only two patients had increased ADC values (1.03 +/- 0.177). There was a statistically significant difference in the FA values between volunteers and patients (P = .012). FA had a much higher sensitivity (SE = 73.3%) and specificity (sp = 100%) in spinal cord abnormalities detection compared with T2-weighted FSE imaging (se = 46.7%, sp = 100%) and ADC (SE = 13.4%, sp = 80%).
  
  
  CONCLUSIONS
  FA has the highest sensitivity and specificity in the detection of acute spinal cord abnormalities. Spinal cord fiber tracking is a useful tool to focus measurements on the compressed spinal cord.
authors.affiliation: Department of Neuroradiology, C.H.U. de Bicêtre, Paris XI University, Le Kremlin-Bicêtre, France.
authors.forename: David
authors.initials: D
authors.lastname: Facon
authors.forename: Augustin
authors.initials: A
authors.lastname: Ozanne
authors.forename: Pierre
authors.initials: P
authors.lastname: Fillard
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Lepeintre
authors.forename: Caroline
authors.initials: C
authors.lastname: Tournoux-Facon
authors.forename: Denis
authors.initials: D
authors.lastname: Ducreux
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013117:Spinal Cord Compression / Q000473:pathology*