Age-dependent susceptibility of adult hippocampal cell proliferation to chronic psychosocial stress.
Stress inhibits neurogenesis in the adult dentate gyrus. It is not known, however, whether age has any influence on this process. We subjected adult male tree shrews to 5 weeks of psychosocial stress, after which dentate cytogenesis was determined using BrdU immunohistochemistry. We found that older animals were significantly more vulnerable to the adverse effect of stress on dentate cell proliferation.
Simon
Mária
M
Clinical Neurobiology Laboratory, German Primate Center, University of Göttingen, Kellnerweg 4, 37077 Göttingen, Germany.
Czéh
Boldizsár
B
Fuchs
Eberhard
E
D000311:Adrenal Glands / Q000473:pathology; D000367:Age Factors; D000375:Aging / Q000502:physiology*; D000818:Animals; D001973:Bromodeoxyuridine / Q000378:metabolism; D002452:Cell Count / Q000379:methods; D006624:Hippocampus / Q000473:pathology*; D016014:Linear Models; D009474:Neurons / Q000473:pathology*; D009929:Organ Size; D013315:Stress, Psychological / Q000503:physiopathology*; D014418:Tupaiidae
D001973:Bromodeoxyuridine