Dramatic change in the tertiary structure of giant DNA without distortion of the secondary structure caused by pteridine-polyamine conjugates.
Pteridine-polyamine conjugates, such as 2-polyamine (1,3-diaminopropane and spermine) substituted 6,7-dimethyl-3H-pteridine-4-one, induce a folding transition of a giant DNA molecule more effectively than the corresponding polyamines. However, since neither a DNA high-temperature shift of denaturation (Tm) curve nor distortion of the UV/fluorescence spectra is observed in a mixture of these compounds with DNA, they do not interact with the DNA duplex strongly.
Chen
Ning
N
Graduate School of Environmental Studies, Nagoya University, Chikusa, Japan.
Murata
Shizuaki
S
Yoshikawa
Kenichi
K
D017122:Bacteriophage T4 / Q000235:genetics*; D015317:Biogenic Polyamines / Q000737:chemistry*; D004247:DNA / Q000737:chemistry* / Q000648:ultrastructure; D006801:Humans; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D011621:Pteridines / Q000737:chemistry*
D015317:Biogenic Polyamines; D011621:Pteridines; D004247:DNA