Beyond the HLA typing age: genetic polymorphisms predicting transplant outcome.
Although histocompatibility testing and matching for histocompatibility leukocyte antigens (HLA) remains the "state of the art" for determining donor selection, non-HLA encoded genes such as those for minor histocompatibiity antigens also play an important role in determining haematopoietic stem cell transplantation (HSCT) outcome. Single nucleotide polymorphisms (SNPs) within the promoter regulatory regions of non-HLA encoded genes such as those for cytokines and cytokine receptors which regulate the production of such molecules may also play a role in determining the extent of post-transplant complications. Mannose binding lectin genes (MBL) and other genes such as those for myeloperoxidase (MPO) and Fcgamma receptor may aid in the control of infection post transplant. This review will summarise the latest research concerning this area of predicting HSCT outcome and indicate the potential clinical use of the results.
Dickinson
Anne M
AM
School of Clinical and Laboratory Sciences, University of Newcastle upon Tyne, The Medical School, Newcastle upon Tyne NE2 4HH, UK. a.m.dickinson@ncl.ac.uk
Middleton
Peter G
PG
D006085:Graft Survival / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics; D018380:Hematopoietic Stem Cell Transplantation; D006648:Histocompatibility / Q000235:genetics*; D006650:Histocompatibility Testing / Q000379:methods; D006801:Humans; D015778:Minor Histocompatibility Antigens / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*; D014184:Transplantation, Homologous
D006680:HLA Antigens; D015778:Minor Histocompatibility Antigens