Pregnancy outcome after maternal organ transplantation in Sweden.
OBJECTIVE
To study pregnancy outcome before and after organ transplantation.


METHODS
Registry study.


METHODS
Swedish Health Registers.


METHODS
All births in Sweden 1973-2002.


METHODS
Women who had organ transplantation were identified from the Hospital Discharge Register and their deliveries before and after the transplantation were identified from the Medical Birth Register. Abortions requiring hospitalisation were identified from the Hospital Discharge Register. Outcomes were compared with those in the total population. Adjustments were made for maternal age, parity and smoking habits.


METHODS
Miscarriage, preterm delivery, low birthweight, small for gestational age, congenital malformations, infant death, pre-eclampsia and placental abruption.


RESULTS
A total of 980 infants born before and 152 born after transplantation were identified. A high frequency of pre-eclampsia (22%), preterm birth (46%), low birthweight (41%), small for gestational age (16%) and infant death (5% before the age of one) were found for deliveries after transplantation but similar frequencies were found also among deliveries a few years before transplantation. No significant increase in congenital malformation rate was seen. Among 15 infants born after liver transplantation, 2 were malformed.


CONCLUSIONS
Pregnancies after organ transplantation have an increased risk of complications but this is similar to pregnancies occurring before the transplantation.
Källén
Bengt
B
Tornblad Institute, University of Lund, Sweden.
Westgren
Magnus
M
Aberg
Anders
A
Olausson
Petra Otterblad
PO
D000328:Adult; D000013:Congenital Abnormalities / Q000453:epidemiology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D008423:Maternal Age; D016017:Odds Ratio; D016377:Organ Transplantation / Q000706:statistics & numerical data*; D010298:Parity; D011225:Pre-Eclampsia / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011256:Pregnancy Outcome / Q000453:epidemiology*; D047928:Premature Birth; D012042:Registries; D013548:Sweden / Q000453:epidemiology
D007166:Immunosuppressive Agents