title: 3 Tesla MR imaging provides improved contrast in first-pass myocardial perfusion imaging over a range of gadolinium doses.
abstract: OBJECTIVE
  To compare myocardial enhancement during first-pass myocardial perfusion imaging at 3.0 Tesla (T) and 1.5T.
  
  
  METHODS
  First-pass myocardial perfusion imaging was performed on twelve normal subjects at 3T and 1.5T using an interleaved notched saturation recovery gradient echo pulse sequence. Subjects received either 0.10 mmol/kg for both scans (group 1), 0.075 mmol/kg for both scans (group 2), or 0.075 mmol/kg for the 3T scan and 0.10 mmol/kg for the 1.5T scan (group 3).
  
  
  RESULTS
  Contrast enhancement was significantly greater at 3T than at 1.5T for the 12 subjects whether enhancement was normalized to baseline signal intensity (2.58 +/- 0.76 vs. 1.52 +/- 0.37, p < 0.0001) or to noise (57.6 +/- 19.7 vs. 14.7 +/- 7.8, p < 0001). For each of the three groups, contrast enhancement was significantly greater at 3T versus 1.5T (p < 0.0001, p < 0.001, p < 0.008 when normalized to baseline signal; p < 0.0001 for all groups when normalized to noise).
  
  
  CONCLUSIONS
  3T improves contrast in first-pass myocardial perfusion imaging at either 0.10 mmol/kg or 0.075 mmol/kg.
authors.affiliation: Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905, USA. araoz.philip@mayo.edu
authors.forename: Philip A
authors.initials: PA
authors.lastname: Araoz
authors.forename: James F
authors.initials: JF
authors.lastname: Glockner
authors.forename: Kiaran P
authors.initials: KP
authors.lastname: McGee
authors.forename: D Dean
authors.initials: DD
authors.lastname: Potter
authors.forename: V Uma
authors.initials: VU
authors.lastname: Valeti
authors.forename: David W
authors.initials: DW
authors.lastname: Stanley
authors.forename: Timothy F
authors.initials: TF
authors.lastname: Christian
mesh_terms: D000328:Adult; D003287:Contrast Media / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D019786:Gadolinium DTPA / Q000008:administration & dosage*; D015637:Gated Blood-Pool Imaging; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D009206:Myocardium / Q000473:pathology*
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA