A weak B antigen with serologic reactivity between B1 and B2 red blood cells found in a Chinese family.
During a serologic study on red cell samples from individuals representing three generations of a Chinese family, an unusual pattern of reactivity was noted in a sample from a daughter of an A1B2 individual. The results of direct ABO grouping, titration, and adsorption studies demonstrated that the red blood cells (RBCs) from the proposita and two of the proposita's uncles (1) expressed more B antigen than group B2 RBCs but less than group B1 RBCs; (2) expressed the B1 antigen but at a lower level than group B1 RBCs; and (3) expressed more H antigen than B1 RBCs but slightly less than B2 RBCs. The saliva from the proposita contained soluble B and H antigens, and her serum contained a weak B-gene-specified transferase. Serologic reactivity of her RBCs was intermediate between that of B1 and B2, RBCs. That is similar to reactivity of Aint RBCs, which is intermediate between A, and A2 RBCs. The proposita may represent a Bint phenotype.
Zhang
G L
GL
Shanghai Institute of Blood Transfusion, China.
Wang
Y
Y
Zheng
J
J
Lee
A
A
Eckrich
R J
RJ
Mallory
D M
DM
Lee
T D
TD