Strategies for targeting protein-protein interactions with synthetic agents.
The development of small-molecule modulators of protein-protein interactions is a formidable goal, albeit one that possesses significant potential for the discovery of novel therapeutics. Despite the daunting challenges, a variety of examples exists for the inhibition of two large protein partners with low-molecular-weight ligands. This review discusses the strategies for targeting protein-protein interactions and the state of the art in the rational design of molecules that mimic the structures and functions of their natural targets.
Yin
Hang
H
Yale University, New Haven, CT, USA.
Hamilton
Andrew D
AD
D000818:Animals; D030541:Databases, Genetic; D015195:Drug Design; D006801:Humans; D011485:Protein Binding / Q000187:drug effects; D011506:Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism*; D013379:Substrate Specificity
D011506:Proteins