title: Hemodynamics and oxygen saturation during intravenous sedation for office-based laser-assisted uvuloplasty.
abstract: OBJECTIVE
  Patients undergoing office-based laser-assisted uvuloplasty (LAUP) for snoring or mild obstructive sleep apnea are generally obese and have a high Mallampati score. Because avoidance of supplemental oxygen during laser procedures is generally mandated, the potential for intraoperative desaturation is high. This study was designed to look at intraoperative hemodynamic changes, respiration patterns, and oxygen saturations during intravenous sedation with midazolam and fentanyl during LAUP procedures.
  
  
  METHODS
  This was a retrospective anesthesia chart review of 15 consecutive patients undergoing midazolam/fentanyl intravenous sedation for office-based LAUP treatment for snoring and/or mild obstructive sleep apnea. Data recorded were noninvasive baseline and intraoperative hemodynamic measurements at 5-minute intervals for systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), pulse pressure (PP), pulse (P), and rate-pressure product (RPP). Data collected were reported as mean values with standard deviation. Statistical analysis using the Student's t test was performed and found significant for P<.05.
  
  
  RESULTS
  All changes from baseline were statistically insignificant, SBP (P=.4), DBP (P=.2), MAP (P=.2), P (P=.1), PP (P=.9), RPP (P=.5), RR (P=.9), and SpO2 (P=.4), and all within +/-20% of baseline (range, -5.0% to +7.5%).
  
  
  CONCLUSIONS
  Midazolam and fentanyl intravenous sedation with local anesthesia maintained intraoperative hemodynamic and oxygenation variables close to baseline for office-based LAUP procedures.
authors.affiliation: Oral and Maxillofacial Surgery, Parkland Memorial Hospital, The University of Texas Southwestern Medical Center, Dallas, USA.
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Cillo
authors.forename: Richard
authors.initials: R
authors.lastname: Finn
mesh_terms: D000556:Ambulatory Surgical Procedures / Q000379:methods; D000766:Anesthesia, Dental / Q000379:methods*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D016292:Procedural Sedation / Q000379:methods*; D005283:Fentanyl / Q000008:administration & dosage / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D008874:Midazolam / Q000008:administration & dosage / Q000494:pharmacology; D016343:Monitoring, Intraoperative; D019647:Oral Surgical Procedures / Q000379:methods*; D010100:Oxygen / Q000097:blood; D010160:Palate, Soft / Q000601:surgery*; D012189:Retrospective Studies; D020181:Sleep Apnea, Obstructive / Q000601:surgery*; D012913:Snoring / Q000601:surgery
chemical_list: D018686:Anesthetics, Intravenous; D008874:Midazolam; D010100:Oxygen; D005283:Fentanyl