title: White blood cell counts and malaria.
abstract: White blood cells (WBCs) were counted in 4697 individuals who presented to outpatient malaria clinics in Maesod, Tak Province, Thailand, and Iquitos, Peru, between 28 May and 28 August 1998 and between 17 May and 9 July 1999. At each site and in each year, WBC counts in the Plasmodium falciparum-infected patients were lower than those in the Plasmodium vivax-infected patients, which, in turn, were lower than those in the uninfected patients. In Thailand, one-sixth of the P. falciparum-infected patients had WBC counts of <4000 cells/microL. Leukopenia may confound population studies that estimate parasite densities on the basis of an assumed WBC count of 8000 cells/microL. For instance, in the present study, use of this conventional approach would have overestimated average asexual parasite densities in the P. falciparum-infected patients in Thailand by nearly one-third.
authors.affiliation: Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA. em225k@nih.gov
authors.forename: F Ellis
authors.initials: FE
authors.lastname: McKenzie
authors.forename: Wendy A
authors.initials: WA
authors.lastname: Prudhomme
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Magill
authors.forename: J Russ
authors.initials: JR
authors.lastname: Forney
authors.forename: Barnyen
authors.initials: B
authors.lastname: Permpanich
authors.forename: Carmen
authors.initials: C
authors.lastname: Lucas
authors.forename: Robert A
authors.initials: RA
authors.lastname: Gasser
authors.forename: Chansuda
authors.initials: C
authors.lastname: Wongsrichanalai
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D006801:Humans; D007958:Leukocyte Count; D007970:Leukopenia / Q000453:epidemiology / Q000469:parasitology*; D016778:Malaria, Falciparum / Q000097:blood*; D016780:Malaria, Vivax / Q000097:blood*; D010568:Peru; D013785:Thailand