title: Chemokine receptor CCR7 is expressed in muscle fibers in juvenile dermatomyositis.
abstract: To better elucidate the pathogenesis of lymphocyte recruitment of memory CD4(+) T cells in inflammatory myopathies, we studied the expression of CCR5 and CCR7 on CD4 memory T cells in muscle tissue from 11 patients with juvenile dermatomyositis, six adult patients with polymyositis, two patients with Duchenne muscular dystrophy, and two patients with spinal muscular atrophy. A prevalent infiltration of CCR5(+) effector CD4 T memory cells is observed in inflammatory myopathies. Moreover, we found a strong expression of CCR7 in perifascicular atrophic and in degenerating/regenerating muscle fibers in juvenile dermatomyositis (JDM) but not in fibers from adult polymyositis and Duchenne muscular dystrophy. The selective expression of CCR7 in JDM may open new perspectives in the understanding of the pathogenesis of inflammatory myopathies, offering a new tool for the differential diagnosis of these disorders.
authors.affiliation: Neuromuscular Disease Unit, University of Genova and G. Gaslini Institute, Genoa, Italy. minettic@unige.it
authors.forename: Carlo
authors.initials: C
authors.lastname: Minetti
authors.forename: Marco
authors.initials: M
authors.lastname: Gattorno
authors.forename: Silvia
authors.initials: S
authors.lastname: Repetto
authors.forename: Andrea
authors.initials: A
authors.lastname: Gregorio
authors.forename: Marina
authors.initials: M
authors.lastname: Pedemonte
authors.forename: Stefania
authors.initials: S
authors.lastname: Assereto
authors.forename: Federico
authors.initials: F
authors.lastname: Zara
authors.forename: Claudio
authors.initials: C
authors.lastname: Bruno
authors.forename: Alberto
authors.initials: A
authors.lastname: Martini
mesh_terms: D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D003882:Dermatomyositis / Q000276:immunology* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D018485:Muscle Fibers, Skeletal / Q000276:immunology* / Q000378:metabolism; D018482:Muscle, Skeletal / Q000276:immunology* / Q000378:metabolism; D019713:Receptors, CCR5 / Q000276:immunology* / Q000378:metabolism; D054400:Receptors, CCR7; D019707:Receptors, Chemokine / Q000276:immunology* / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: C515370:CCR7 protein, human; D019713:Receptors, CCR5; D054400:Receptors, CCR7; D019707:Receptors, Chemokine