Follow-up study on pulmonary function and lung radiographic changes in rehabilitating severe acute respiratory syndrome patients after discharge.
OBJECTIVE
To follow-up on the changes in lung function and lung radiographic pictures of severe acute respiratory syndrome (SARS) patients discharged from Xiaotangshan Hospital in Beijing (by regularly receiving examination), and to analyze retrospectively the treatment strategy in these patients.


METHODS
Surviving SARS patients were seen at least twice within 3 months after discharge and underwent SARS-associated coronavirus (SARS-CoV) IgG antibody testing, pulmonary function testing, and chest radiography and/or high-resolution CT (HRCT) examinations at Chinese PLA General Hospital. The treatments received at Xiaotangshan Hospital were analyzed retrospectively and were correlated to later status.


RESULTS
Positive SARS-Co virus IgG antibody results were seen in 208 of 258 patients, with 21.3% (55 of 258 patients) still having a pulmonary diffusion abnormality (D(LCO) < 80% of predicted). By comparing the 155 survivors with positive SARS-CoV IgG antibody results and D(LCO) > or = 80% predicted with the 50 patients with negative SARS-CoV IgG results, we found that 53 patients with positive SARS-CoV IgG results and a lung diffusion abnormality had endured a much longer course of fever and received larger doses of glucocorticoid, as well as higher ratios of oxygen inhalation and noninvasive ventilation treatment. For these patients, 51 of 53 patients with positive SARS-CoV IgG results and a lung diffusion abnormality underwent pulmonary function testing after approximately 1 month. D(LCO) improved in 80.4% of patients (41 of 51 patients). Of the patients with a lung diffusion abnormality, 40 of 51 patients showed lung fibrotic changes in the lung image examination and 22 patients (55%) showed improvement in lung fibrotic changes 1 month later.


CONCLUSIONS
These findings suggest that lung fibrotic changes caused by SARS disease occurred mostly in severely sick patients and may be self-rehabilitated. D(LCO) scores might be more sensitive than HRCT when evaluating lung fibrotic changes.
Xie
Lixin
L
Department of Respiratory Medicine, Chinese PLA General Hospital, 28 Fuxing Rd, Beijing 100853, Peoples Republic of China.
Liu
Youning
Y
Xiao
Yueyong
Y
Tian
Qing
Q
Fan
Baoxing
B
Zhao
Hong
H
Chen
Weijun
W
D000293:Adolescent; D000328:Adult; D000359:Aftercare; D000367:Age Factors; D000368:Aged; D002681:China; D015331:Cohort Studies; D003131:Combined Modality Therapy; D003266:Continuity of Patient Care; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000627:therapeutic use*; D013902:Radiography, Thoracic / Q000379:methods; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D018570:Risk Assessment; D045169:Severe Acute Respiratory Syndrome / Q000175:diagnosis* / Q000534:rehabilitation / Q000628:therapy*; D012720:Severity of Illness Index; D012737:Sex Factors; D014057:Tomography, X-Ray Computed
D005938:Glucocorticoids; D010100:Oxygen