[Phospholipid membrane modification as a protection factor of the myocardium during stress injury].
In experiments on the isolated rat hearts we investigated the influence of phospholipid membrane modification by omega-3 polyunsaturated fatty acids (PUFAs) on the heart reactivity to adrenergic influences, myocardial ultrastructure and peroxidation processes under the immobilization stress. It was shown that omega-3 PUFAs reduced ultrastructural changes in the heart, limited lipid peroxidation and attenuated inotropic response of the heart to exogenous norepinephrine.
Shysh
A M
AM
O. O. Bogomoletz Institute of Physiology, National Academy of Science of Ukraine, Kyiv.
Kukoba
T V
TV
Tumanovs'ka
L V
LV
Moĭbenko
O O
OO
D000208:Acute Disease; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D004195:Disease Models, Animal; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology; D005609:Free Radicals / Q000378:metabolism; D066298:In Vitro Techniques; D015227:Lipid Peroxidation; D008297:Male; D008854:Microscopy, Electron; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology*; D009206:Myocardium / Q000378:metabolism* / Q000648:ultrastructure; D009638:Norepinephrine / Q000494:pharmacology; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000378:metabolism* / Q000503:physiopathology
D015525:Fatty Acids, Omega-3; D005609:Free Radicals; D010743:Phospholipids; D009638:Norepinephrine