title: [A case of sub-acute onset pulmonary sarcoidosis with pulmonary dysfunction].
abstract: A 60-year-old man was admitted to our hospital because of shortness of breath and dry cough. Slight pleural thickening was observed on the chest X-ray film and chest CT on presenting. Three months later, bilateral hilar lymphadenopathy and multiple small nodular shadows were shown in both lung fields by chest CT. Serum ACE level and lysozyme levels were higher than normal upper limit. Elevation of CRP and left shift of leukocytes were not detected. Restrictive ventilatory impairment was shown in the respiratory function test. This case was diagnosed as sarcoidosis most probably with histological evidence of epithelioid cell granulomas in the lung tissue obtained by transbronchial lung biopsy. After prednisolone medication (40 mg per day) was started, symptoms, pulmonary function and chest CT findings improved. Our case was considered to be a rare case of pulmonary sarcoidosis with subacute onset of symptoms and restrictive pulmonary function abnormality which improved smoothly as a result of steroid therapy.
authors.affiliation: Department of Respiratory Medicine, Yokohama-city Seibu Hospital St. Marianna University, School of Medicine.
authors.forename: Hiroo
authors.initials: H
authors.lastname: Saito
authors.forename: Mizuki
authors.initials: M
authors.lastname: Ikehara
authors.forename: Yuko
authors.initials: Y
authors.lastname: Komase
authors.forename: Seiki
authors.initials: S
authors.lastname: Omiya
authors.forename: Takemasa
authors.initials: T
authors.lastname: Nakagawa
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage*; D012131:Respiratory Insufficiency / Q000150:complications*; D017565:Sarcoidosis, Pulmonary / Q000000981:diagnostic imaging / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone