Immunocytochemical distribution of NK-1 and NK-3 tachykinin receptors in isolated pancreatic acini of guinea pigs and rats.
In this study, we investigated the immunocytochemical distribution of NK-1 and NK-3 tachykinin receptors in guinea pig and rat isolated pancreatic acini. In dispersed acinar cells from guinea pig, immunofluorescence staining detected similar densities of NK-1 and NK-3 receptors; conversely, rat acinar cells expressed NK-1 receptors more strongly than NK-3 receptors. In line with previous functional studies, these immunocytochemical findings suggest that guinea pig NK-1 and NK-3 receptors and rat NK-1 receptors alone play a direct stimulatory role in the basal pancreatic acinar amylase release.
Broccardo
Maria
M
Department of Human Physiology and Pharmacology, V. Erspamer, University La Sapienza, Rome, Italy.
Ciotti
M Teresa
MT
Linari
Giorgio
G
Agostini
Simona
S
Petrella
Carla
C
Amadoro
Giusy
G
Severini
Cinzia
C
Improta
Giovanna
G
D000681:Amylases / Q000378:metabolism; D000818:Animals; D006168:Guinea Pigs; D007150:Immunohistochemistry; D008297:Male; D046790:Pancreas, Exocrine / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D018040:Receptors, Neurokinin-1 / Q000096:biosynthesis*; D018042:Receptors, Neurokinin-3 / Q000096:biosynthesis*; D013045:Species Specificity
D018040:Receptors, Neurokinin-1; D018042:Receptors, Neurokinin-3; D000681:Amylases