Gitelman's syndrome presenting as intolerance to statin therapy.
Several factors predisposing patients to statin-induced myopathy have been described. We describe a patient whose statin intolerance was associated with changes in serum potassium arising from previously undiagnosed Gitelman's syndrome.
Freedman
Danielle B
DB
Department of Chemical Pathology, Luton and Dunstable Hospital, Lewsey Road, Luton LU4 0DZ, UK.
Housley
David
D
D000328:Adult; D000584:Amiloride / Q000008:administration & dosage / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D006937:Hypercholesterolemia / Q000188:drug therapy; D007008:Hypokalemia / Q000188:drug therapy*; D007674:Kidney Diseases / Q000188:drug therapy*; D008274:Magnesium / Q000097:blood; D009135:Muscular Diseases / Q000139:chemically induced; D010146:Pain / Q000139:chemically induced; D011188:Potassium / Q000097:blood; D017035:Pravastatin / Q000008:administration & dosage / Q000627:therapeutic use; D013148:Spironolactone / Q000009:adverse effects / Q000627:therapeutic use; D013577:Syndrome
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D013148:Spironolactone; D000584:Amiloride; D002784:Cholesterol; D008274:Magnesium; D017035:Pravastatin; D011188:Potassium