title: Benefits, harms, and the design of clinical trials.
authors.forename: Donald A
authors.initials: DA
authors.lastname: Brand
mesh_terms: D001294:Attitude to Health; D002986:Clinical Trials as Topic / Q000009:adverse effects / Q000191:economics / Q000941:ethics*; D003362:Cost-Benefit Analysis; D003661:Decision Support Techniques; D006801:Humans; D019458:Insurance Coverage; D018579:Patient Selection; D012107:Research Design; D018570:Risk Assessment / Q000191:economics