Intermediate mutation frequencies favor evolution of multidrug resistance in Escherichia coli.
In studying the interplay between mutation frequencies and antibiotic resistance among Escherichia coli natural isolates, we observed that modest modifications of mutation frequency may significantly influence the evolution of antibiotic resistance. The strains having intermediate mutation frequencies have significantly more antibiotic resistances than strains having low and high mutation frequencies.
Denamur
Erick
E
INSERM U571 and Université Paris 5, France.
Tenaillon
Olivier
O
Deschamps
Catherine
C
Skurnik
David
D
Ronco
Esthel
E
Gaillard
Jean Louis
JL
Picard
Bertrand
B
Branger
Catherine
C
Matic
Ivan
I
D000900:Anti-Bacterial Agents / Q000633:toxicity; D018432:Drug Resistance, Multiple / Q000235:genetics*; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D019143:Evolution, Molecular; D006801:Humans; D009154:Mutation / Q000235:genetics*; D014556:Urine / Q000382:microbiology
D000900:Anti-Bacterial Agents