title: Linear motifs: evolutionary interaction switches.
abstract: Linear motifs are short sequence patterns associated with a particular function. They differ fundamentally from longer, globular protein domains in terms of their binding affinities, evolution and in how they are found experimentally or computationally. In this Minireview, we discuss various aspects of these critically important functional regions.
authors.affiliation: EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
authors.forename: Victor
authors.initials: V
authors.lastname: Neduva
authors.forename: Robert B
authors.initials: RB
authors.lastname: Russell
mesh_terms: D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D008969:Molecular Sequence Data; D009696:Nucleic Acids / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: D009696:Nucleic Acids