Insights into CD4+ memory T cells following Leishmania infection.
Recent publications by Zaph et al. have highlighted the distinct requirements for generating and maintaining different subpopulations of CD4(+) memory T cells after infection with Leishmania major in mice. These studies have advanced the understanding of the nature of long-lasting immunity to Leishmania and, when considered within the context of previous work on both murine and human leishmaniasis, will aid the design of effective vaccines.
Gollob
Kenneth J
KJ
Department of Biochemistry and Immunology, Federal University of Minas Gerais, Institute for Biological Sciences, Belo Horizonte 30161-970, Brazil. kjgollob@icb.ufmg.br
Antonelli
Lis R V
LR
Dutra
Walderez O
WO
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000469:parasitology; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D007891:Leishmania / Q000276:immunology*; D007896:Leishmaniasis / Q000276:immunology* / Q000469:parasitology; D017780:Malaria Vaccines / Q000276:immunology; D051379:Mice; D016176:T-Lymphocyte Subsets / Q000276:immunology
D017780:Malaria Vaccines