title: Exercise training in mitochondrial myopathy: a randomized controlled trial.
abstract: Patients with mitochondrial myopathies (MM) usually suffer from exercise intolerance due to their impaired oxidative capacity and physical deconditioning. We evaluated the effects of a 12-week supervised randomized rehabilitation program involving endurance training in patients with MM. Twenty MM patients were assigned to a training or control group. For three nonconsecutive days each week, patients combined cycle exercise at 70% of their peak work rate with three upper-body weight-lifting exercises performed at 50% of maximum capacity. Training increased maximal oxygen uptake (28.5%), work output (15.5%), and minute ventilation (40%), endurance performance (62%), walking distance in shuttle walking test (+95 m), and peripheral muscle strength (32%-62%), and improved Nottingham Health Profile scores (21.47%) and clinical symptoms. Control MM patients did not change from baseline. Results show that our exercise program is an adequate training strategy for patients with mitochondrial myopathy.
authors.affiliation: Chest Department, Hospital Universitario Virgen del Rocío, 41013 Seville, Spain. pilarcejudo@terra.es
authors.forename: Pilar
authors.initials: P
authors.lastname: Cejudo
authors.forename: Juan
authors.initials: J
authors.lastname: Bautista
authors.forename: Teodoro
authors.initials: T
authors.lastname: Montemayor
authors.forename: Rafael
authors.initials: R
authors.lastname: Villagómez
authors.forename: Luis
authors.initials: L
authors.lastname: Jiménez
authors.forename: Francisco
authors.initials: F
authors.lastname: Ortega
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Campos
authors.forename: Hildegard
authors.initials: H
authors.lastname: Sánchez
authors.forename: Joaquín
authors.initials: J
authors.lastname: Arenas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy / Q000379:methods*; D017079:Exercise Tolerance / Q000502:physiology*; D005260:Female; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D008297:Male; D008451:Maximal Voluntary Ventilation / Q000502:physiology; D008875:Middle Aged; D017240:Mitochondrial Myopathies / Q000503:physiopathology / Q000628:therapy*; D018908:Muscle Weakness / Q000503:physiopathology / Q000628:therapy*; D018482:Muscle, Skeletal / Q000502:physiology; D010101:Oxygen Consumption / Q000502:physiology; D010809:Physical Fitness / Q000502:physiology*; D011788:Quality of Life; D020127:Recovery of Function / Q000502:physiology; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D019344:Lactic Acid