The C3435T polymorphism of MDR1 and susceptibility to adult glioma.
BACKGROUND
The multidrug resistance-1 (MDR1) gene encodes a pump that prevents potentially carcinogenic substances from crossing the blood-brain barrier. We compare adult glioma cases and controls for the C3435T polymorphism that has been associated with reduced MDR1 expression.


METHODS
Adult glioma in the San Francisco Bay area and population-based controls were identified between 1991-1994 and 1997-1999. Genotyped cases (n = 458) and controls (n = 528) were compared using logistic regression controlling for age, gender and ethnicity, with later stratification by ethnicity, gender and histology.


RESULTS
With CC as the referent, the TT genotype was nonsignificantly less frequent among cases compared to controls (OR, 0.87; 95% CI: 0.6, 1.2). After stratification, only male glioblastoma was associated with TT genotype (OR, 0.51; 95% CI: 0.3, 1.0).


CONCLUSIONS
Although the C3435T polymorphism does not appear to be associated with other types of glioma, we cannot rule out that this MDR1 polymorphism may be associated with glioblastoma among men.
Miller
Katie L
KL
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA. kmiller@hsph.harvard.edu
Kelsey
Karl T
KT
Wiencke
John K
JK
Moghadassi
Michelle
M
Miike
Rei
R
Liu
Mei
M
Wrensch
Margaret
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000209:etiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D019450:Genes, MDR; D020022:Genetic Predisposition to Disease; D005910:Glioma / Q000209:etiology / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012044:Regression Analysis