NaOH-catalyzed crossed Claisen condensation between ketene silyl acetals and methyl esters.
We have developed a practical crossed Claisen condensation between ketene silyl acetals and methyl esters using catalytic NaOH to obtain alpha-monoalkylated beta-keto esters and inaccessible alpha,alpha-dialkylated beta-keto esters.
Iida
Akira
A
Department of Chemistry, School of Science and Technology, Kwansei Gakuin University, Hyogo, Japan.
Takai
Kenta
K
Okabayashi
Tomohito
T
Misaki
Tomonori
T
Tanabe
Yoo
Y