title: Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future.
abstract: Tyrosinase is known to be a key enzyme in melanin biosynthesis, involved in determining the color of mammalian skin and hair. Various dermatological disorders, such as melasma, age spots and sites of actinic damage, arise from the accumulation of an excessive level of epidermal pigmentation. In addition, unfavorable enzymatic browning of plant-derived foods by tyrosinase causes a decrease in nutritional quality and economic loss of food products. The inadequacy of current conventional techniques to prevent tyrosinase action encourages us to seek new potent tyrosinase inhibitors. This article overviews the various inhibitors obtained from natural and synthetic sources with their industrial importance.
authors.affiliation: Center for Advanced Science and Innovation, Osaka University, Suita, Osaka, 565-0871, Japan.
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Kim
authors.forename: H
authors.initials: H
authors.lastname: Uyama
mesh_terms: D000383:Agriculture; D000818:Animals; D003358:Cosmetics; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology; D019649:Food Industry; D005544:Forecasting; D005658:Fungi / Q000378:metabolism; D015416:Maillard Reaction; D008543:Melanins / Q000096:biosynthesis; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000145:classification; D010636:Phenols / Q000494:pharmacology; D010944:Plants / Q000378:metabolism; D059808:Polyphenols
chemical_list: D003358:Cosmetics; D004791:Enzyme Inhibitors; D005419:Flavonoids; D008543:Melanins; D010636:Phenols; D059808:Polyphenols; D014442:Monophenol Monooxygenase