MSI1-like proteins: an escort service for chromatin assembly and remodeling complexes.
MSI1-like WD40 repeat proteins are subunits of many protein complexes controlling chromatin dynamics. These proteins do not have any catalytic activity, but several recent studies using loss-of-function mutants established specific functions during development. Here, we review the current knowledge of MSI1-like proteins, including their phylogenetic history, expression patterns, biochemical interactions and mutant phenotypes. MSI1-like proteins, which are often targets or partners of tumor-suppressor proteins, are required during cell proliferation and differentiation in flies, nematodes and plants. We discuss the possibility that MSI1-like proteins could function to maintain epigenetic memory during development by targeting silencing complexes to chromatin during nucleosome assembly.
Hennig
Lars
L
Institute of Plant Sciences, Swiss Federal Institute of Technology and Zürich-Basel Plant Science Center, ETH Center, CH-8092 Zürich. lars.henning@ipw.biol.ethz.ch
Bouveret
Romaric
R
Gruissem
Wilhelm
W
D000818:Animals; D002454:Cell Differentiation; D002843:Chromatin / Q000235:genetics / Q000378:metabolism*; D042002:Chromatin Assembly and Disassembly; D006657:Histones / Q000378:metabolism; D006801:Humans; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding
D002843:Chromatin; D006657:Histones; D008840:Microfilament Proteins