title: A pheochromocytoma causing limited coagulopathy with hemoptysis.
abstract: We treated a 59-year-old woman presenting with hemoptysis, a rare symptom of pheochromocytoma. Multiple factors including hypertension caused by sudden catecholamine release may result in pulmonary edema. It should be noted that the increased activation of coagulation cascade, which was demonstrated by increased thrombin-antithrombin III complex (TAT) and prothrombin fragment factor 1 and 2 (F1 + 2), as well as endothelial or platelet stimulation evidenced by the increased plasma von Willebrand factor, may have contributed to hemoptysis. These abnormalities were normalized after adrenalectomy. Our case indicates the important role of catecholamine in coagulopathy and possibly in vasculopathy.
authors.affiliation: Institute of Oriental Medicine, Tokyo Women's Medical University School of Medicine, 2-4-1 Nishishin juku, Shin juku-ku, Tokyo 163-0804, Japan. ykimura@iom.twmu.ac.jp
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kimura
authors.forename: Hideki
authors.initials: H
authors.lastname: Ozawa
authors.forename: Mihoko
authors.initials: M
authors.lastname: Igarashi
authors.forename: Tomooki
authors.initials: T
authors.lastname: Iwamoto
authors.forename: Kenzo
authors.initials: K
authors.lastname: Nishiya
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Urano
authors.forename: Shinya
authors.initials: S
authors.lastname: Goto
mesh_terms: D019797:3-Iodobenzylguanidine; D001778:Blood Coagulation Disorders / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology*; D001779:Blood Coagulation Factors / Q000378:metabolism; D002395:Catecholamines / Q000652:urine; D005260:Female; D006469:Hemoptysis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D010673:Pheochromocytoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology*; D011859:Radiography; D015898:Tomography Scanners, X-Ray Computed
chemical_list: D001779:Blood Coagulation Factors; D002395:Catecholamines; D019797:3-Iodobenzylguanidine