title: [A case of Kimura's disease accompanied with bilateral, mediastinal and hilar lymphadenopathy].
abstract: A 52-year-old man presented with general fatigue and body weight loss. Chest X-ray and computed tomography showed bilateral, mediastinal and hilar lymphadenopathy. Laboratory tests revealed that peripheral eosinophils (1,850/microL) and serum IgE levels (1,610 U/L) were markedly increased. Cervical lymph node biopsy was performed for a definitive diagnosis. Histopathological analysis, using conventional H&E staining, showed mild infiltration of eosinophils into lymphoid follicules in the cervical lymph node. Immunohistopathological analysis, using an anti-human IgE antibody, showed mesh-like IgE positive staining in lymphoid follicles. These clinical and pathological findings are compatible with a diagnosis of Kimura's disease.
authors.affiliation: Department of Internal Medicine 1, Kurume University School of Medicine.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Kitasato
authors.forename: Morihiro
authors.initials: M
authors.lastname: Tajiri
authors.forename: Kazuko
authors.initials: K
authors.lastname: Matsunaga
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ohshita
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Hoshino
authors.forename: Takeharu
authors.initials: T
authors.lastname: Koga
authors.forename: Hisamichi
authors.initials: H
authors.lastname: Aizawa
mesh_terms: D000796:Angiolymphoid Hyperplasia with Eosinophilia / Q000150:complications*; D003937:Diagnosis, Differential; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008206:Lymphatic Diseases / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D008297:Male; D008477:Mediastinal Diseases / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D008875:Middle Aged
chemical_list: D007073:Immunoglobulin E