Compatibility testing problems associated with bovine thrombin-treated plasma.
Plasma converted to serum by the addition of bovine thrombin prior to compatibility testing agglutinated all donor red cells. This finding prompted an investigation of bovine thrombin- associated incompatibility that showed that (1) thrombin derived from bovine plasma contains IgG antibodies directed against all human red cells, and (2) excess (> 50 units/mL) bovine thrombin used for conversion of plasma to serum may cause hemagglutination and erroneous serologic test results because of the presence of heteroagglutinins.
Shirey
R S
RS
Blood Bank, The Johns Hopkins Hospital, Carnegie Building, Room 667, 600 N. Wolfe Street, Baltimore, MD 21287-6667, USA.
Ciappi
A B
AB
Kickler
T S
TS
Triulzi
D
D
Ness
P M
PM