PRISM: protein interactions by structural matching.
Prism (http://gordion.hpc.eng.ku.edu.tr/prism) is a website for protein interface analysis and prediction of putative protein-protein interactions. It is composed of a database holding protein interface structures derived from the Protein Data Bank (PDB). The server also includes summary information about related proteins and an interactive protein interface viewer. A list of putative protein-protein interactions obtained by running our prediction algorithm can also be accessed. These results are applied to a set of protein structures obtained from the PDB at the time of algorithm execution (January 2004). Users can browse through the non-redundant dataset of representative interfaces on which the prediction algorithm depends, retrieve the list of similar structures to these interfaces or see the results of interaction predictions for a particular protein. Another service provided is interactive prediction. This is done by running the algorithm for user input structures.
Koc University, Center for Computational Biology and Bioinformatics and College of Engineering Rumelifeneri Yolu, Sariyer, Istanbul 34450, Turkey.
Utkan
U
Ogmen
Ozlem
O
Keskin
A Selim
AS
Aytuna
Ruth
R
Nussinov
Attila
A
Gursoy
D000465:Algorithms; D020407:Internet; D011487:Protein Conformation; D025941:Protein Interaction Mapping / Q000379:methods*; D012984:Software; D014584:User-Computer Interface