Unusual metastasis of malignant aortic body tumor to multiple bones in a dog.
Unusual metastasis of malignant aortic body tumor to multiple bones was detected in a 5-year-old female English Setter dog. Radiographs exhibited an abnormal mass in the base of heart and osteolytic lesions in the bodies of T11 and L2 vertebrates, body of right femur, right proximal humoral epiphysis and infraspinous fossa near to the neck of right scapula. At necropsy, multiple tumor masses of various sizes were observed also in the bones as well as the heart base and tracheobronchial lymph node. Tumor masses of L2 and T11 protruded into the vertebral canal and compressed corresponding sites of spinal cord, leading to paraplegia. Histopathologically, the tumor cells, arranged in sheets or nests, were polyhedral, lightly eosinophilic, finely granular cytoplasm with mostly round to oval nucleus and had scattered bizarre giant cells. Ultrastructural study revealed the characteristic findings that tumor cells contained a large number of small, electron-dense, membrane-limited secretory granules in cytoplasm. This is thought to be an extremely rare case having multiple bone metastases of a malignant aortic body tumor.
Veterinary Medical Research Center, College of Veterinary Medicine, Chonnam National University, Gwangju, South Korea.
Sang-Ki
SK
Kim
Chang-Baig
CB
Hyun
Kyoung-Oh
KO
Cho
D000818:Animals; D001016:Aortic Bodies / Q000648:ultrastructure*; D001859:Bone Neoplasms / Q000556:secondary* / Q000648:ultrastructure / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D046529:Microscopy, Electron, Transmission / Q000662:veterinary; D010524:Peripheral Nervous System Neoplasms / Q000648:ultrastructure / Q000662:veterinary*