Total antioxidant capacity of the diet is inversely and independently related to plasma concentration of high-sensitivity C-reactive protein in adult Italian subjects.
Inflammation, a risk factor for cardiovascular disease, is associated with low plasma levels of antioxidant vitamins. In addition to vitamins, other antioxidants modulate the synthesis of inflammatory markers in vitro and contribute to the total antioxidant capacity (TAC) of a diet. However, the relationship between dietary TAC and markers of inflammation has never been evaluated in vivo. We investigated the relationship between dietary TAC and markers of systemic (high-sensitivity C-reactive protein (hs-CRP), leucocytes) and vascular (soluble intercellular cell adhesion molecule-1) inflammation in 243 non-diabetic subjects. General Linear Model (GLM) analysis showed a significant (P=0.005) inverse relationship between hs-CRP and quartiles of energy-adjusted dietary TAC, even when recognized modulating factors of inflammation, namely alcohol, fibre, vitamin C, alpha-tocopherol, beta-carotene, BMI, waist circumference, HDL-cholesterol, hypertension, insulin sensitivity and plasma beta-carotene, were included in the model as covariates (P=0.004). The relationship was stronger for subjects with hypertension (P=0.013 v. P=0.109 for normotensive individuals). Among dietary factors, TAC was significantly higher (5.3 (sd 3.0) v. 4.9 (sd 2.7) mmol Trolox/d; P=0.026) in subjects with low plasma hs-CRP (range: 0.0-4.1 mg/l) than in subjects with high plasma hs-CRP (range: 4.2-27.8 mg/l). We conclude that dietary TAC is inversely and independently correlated with plasma concentrations of hs-CRP and this could be one of the mechanisms explaining the protective effects against CVD of antioxidant-rich foods such as fruits, whole cereals and red wine. This could be of particular significance for subjects with high blood pressure.
Brighenti
Furio
F
Department of Public Health, University of Parma, Parma, Italy.
Valtueña
Silvia
S
Pellegrini
Nicoletta
N
Ardigò
Diego
D
Del Rio
Daniele
D
Salvatore
Sara
S
Piatti
PierMarco
P
Serafini
Mauro
M
Zavaroni
Ivana
I
D000368:Aged; D000428:Alcohol Drinking; D000975:Antioxidants / Q000008:administration & dosage*; D002097:C-Reactive Protein / Q000032:analysis*; D004032:Diet; D004043:Dietary Fiber / Q000008:administration & dosage; D002149:Energy Intake; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000276:immunology; D007249:Inflammation; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D007558:Italy; D007958:Leukocyte Count; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D014815:Vitamins / Q000008:administration & dosage
D000975:Antioxidants; D004043:Dietary Fiber; D014815:Vitamins; D018799:Intercellular Adhesion Molecule-1; D002097:C-Reactive Protein