Studies on the apoptotic activity of natural and synthetic retinoids: discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells.
New terphenyl derivatives have been synthesized and tested for their effect on cell survival in serum-free cultures. These compounds protected HL60 cells from death and supported their growth with an activity higher than that of the natural 14-hydroxy-retro-retinol. Terphenyls 26 and 28 also possess antiapoptotic activity on neuronal cells, proving them as possible candidates for the treatment of neurodegenerative and ischemic diseases.
Simoni
Daniele
D
Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Via Fossato di Mortara 17-19, 44100 Ferrara, Italy. smd@dns.unife.it
Giannini
Giuseppe
G
Roberti
Marinella
M
Rondanin
Riccardo
R
Baruchello
Riccardo
R
Rossi
Marcello
M
Grisolia
Giuseppina
G
Invidiata
Francesco Paolo
FP
Aiello
Stefania
S
Marino
Silvia
S
Cavallini
Sabrina
S
Siniscalchi
Anna
A
Gebbia
Nicola
N
Crosta
Lucia
L
Grimaudo
Stefania
S
Abbadessa
Vincenzo
V
Di Cristina
Antonietta
A
Tolomeo
Manlio
M
D017209:Apoptosis / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D018922:HL-60 Cells; D006801:Humans; D007202:Indicators and Reagents; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D012176:Retinoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D007202:Indicators and Reagents; D012176:Retinoids