MRI T2 hypointensity of the dentate nucleus is related to ambulatory impairment in multiple sclerosis.
OBJECTIVE
MRI T2 hypointensity in multiple sclerosis (MS) gray matter, suggesting iron deposition, is associated with physical disability, disease course, lesion load, and brain atrophy. Ambulatory dysfunction limits quality of life; however correlation with conventional MRI remains poor.


METHODS
Normalized intensity on T2-weighted images was obtained in the basal ganglia, thalamus, red nucleus, and dentate nucleus in 47 MS patients and 15 healthy controls. Brain T1-hypointense and FLAIR-hyperintense lesion volume, third ventricle width, brain parenchymal fraction and timed 25 foot walk (T25FW) were measured in the MS group.


RESULTS
T2 hypointensity was present throughout gray matter in MS vs. controls (all p<0.01). Dentate T2 hypointensity was the only MRI variable significantly correlated with T25FW (Pearson r=-0.355, p=0.007) and was also the best MRI correlate of physical disability (EDSS) score in regression modeling (r=-0.463, R(2)=0.223, p=0.004).


CONCLUSIONS
T2 hypointensity is present in subcortical gray matter nuclei in patients with MS vs. normal controls. Dentate nucleus T2 hypointensity is independently related to ambulatory impairment and disability, accounting for more variance than conventional lesion and atrophy measures. This study adds more weight to the notion that T2 hypointensity is a clinically relevant marker of tissue damage in MS.
Tjoa
C W
CW
Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA.
Benedict
R H B
RH
Weinstock-Guttman
B
B
Fabiano
A J
AJ
Bakshi
R
R
D000328:Adult; D000553:Ambulatory Care; D000704:Analysis of Variance; D001284:Atrophy / Q000473:pathology; D002529:Cerebellar Nuclei / Q000473:pathology*; D015331:Cohort Studies; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000473:pathology*; D012044:Regression Analysis; D015203:Reproducibility of Results; D012720:Severity of Illness Index