Cytotoxic constituents of the fruit body of Daedalea dickisii.
Three new lanostane triterpenoids (1, 7, 8) and five new lanostane triterpene glucosides (2-6) have been isolated from the fruit bodies of Daedalea dickinsii. Their structures were established primarily by NMR experiments, and their biological activity against HL-60 and HCT-15 cell lines was investigated. Compounds 3-6 induced internucleosomal DNA fragmentation characteristic of apoptotic cell death in the HL-60 cell line.
Yoshikawa
Kazuko
K
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-Cho, Japan. yosikawa@ph.bunri-r.ac.jp
Kouso
Kazuaki
K
Takahashi
Jyoji
J
Matsuda
Akiko
A
Okazoe
Mina
M
Umeyama
Akemi
A
Arihara
Shigenobu
S
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D053938:DNA Fragmentation; D004354:Drug Screening Assays, Antitumor; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D007564:Japan; D007810:Lanosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011124:Polyporaceae / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D005960:Glucosides; D014315:Triterpenes; D007810:Lanosterol