[A clinical study of Periocline on the treatment of severe chronic periodontitis].
OBJECTIVE
To evaluate the clinical effect of subgingivally administering Periocline as an auxiliary treatment of chronic periodontitis.


METHODS
A randomized, single-blind, self-control study was designed.Following initial therapy ,Periocline was administered into the periodontal pocket of treatment sides at baseline and week 1 to week 4, but the control sides received no drug. For both groups,standard clinical indices including plaque index (PLI), gingival index(GI), probing depth (PD) and response to the ointments were evaluated at baseline week 1,week 4 and week 8. The plaque index and gingival index were analyzed by Wilcoxon' test for each treatment. The probing depth was analyzed by Student's t test.


RESULTS
At the baseline,there was no significant difference in the indexes between the two groups (P>0.05). At 1 week after treatment, both groups showed significant improvement in their examined indexes (P<0.01). At week 1 the PLI was significantly lower in the experimental group than that in the control group; at week 4 and week 8 there was no significant difference between the groups. At 1 week after the treatment, the GI had no significant difference between the two groups (P>0.05); but there was difference 4 weeks and 8 weeks after treatment. At 1 week after treatment, PD was significantly different between the two groups (P<0.05), while at week 4 and week 8, were significant difference between the two groups (P<0.01).


CONCLUSIONS
Administration of the local drug delivery system of Periocline ointment as the auxiliary treatment of severe chronic Periodontitis could get good clinical results.
Department of Stomatology, Central Hospital of Songjiang District, Shanghai, China. xfuliu@hotmail.com
Rong-ping
RP
Que
Xiao-feng
XF
Liu
Qin-fen
QF
Qian
Lei
L
Qian
D055113:Chronic Periodontitis / Q000188:drug therapy*; D003774:Dental Plaque Index; D006801:Humans; D009824:Ointments; D010514:Periodontal Pocket; D016037:Single-Blind Method
D009824:Ointments