Scaffold proteins dictate Rho GTPase-signaling specificity.
Given the numerous mechanisms that regulate the activity of Rho GTPases and the multiple effectors for Rho proteins, how is specificity achieved when transducing signals via Rho GTPase-regulated molecular networks? The finding that the scaffold protein hCNK1 links Rho guanine-nucleotide-exchange factors and Rho to JNK (c-Jun N-terminal kinase), while limiting stress-fiber formation and serum-response-factor activation, suggests that scaffold proteins govern the selection of signal outputs, thus helping to solve the Rho GTPase-signaling puzzle.
Marinissen
Maria Julia
MJ
Instituto de Investigaciones Biomedicas A. Sols UAM-CSIC, Departamento de Bioquimica, Facultad de Medicina, Universidad Autonoma de Madrid, Arzobispo Morcillo 4, Spain. mjmarinissen@iib.uam.es
Gutkind
J Silvio
JS
D000818:Animals; D003599:Cytoskeleton / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D015398:Signal Transduction; D013379:Substrate Specificity; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
C500833:CNKSR1 protein, human; D047908:Intracellular Signaling Peptides and Proteins; D020741:rho GTP-Binding Proteins