Idiopathic hypereosinophilic syndrome: a case evolving in B-lymphoblastic lymphoma.
Idiopathic hypereosinophilic syndrome (HES) is a rare disease characterized by tissue involvement and organ dysfunction due to abnormal eosinophil proliferation. Evolution of HES into myeloid or T-cell malignancies has been frequently reported. Here, we describe a case of HES that preceded the occurrence of a high-grade B-lymphoblastic lymphoma in which clonal evolution has been demonstrated at the molecular level.
Dipartimento di Medicina Interna, Facoltà di Medicina e Chirurgia, University Tor Vergata, Viale Oxford 81, 00133 Rome, Italy.
Maria Cristina
MC
Rapanotti
Roberta
R
Caruso
Sergio
S
Bernardini
Valentina
V
Coletti
Francesco
F
Lo-Coco
Giulio
G
De Rossi
D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications* / Q000175:diagnosis; D007223:Infant; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000175:diagnosis; D012074:Remission Induction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014158:Transcription, Genetic
D015514:Oncogene Proteins, Fusion