Dietary supplement-related adverse events reported to the California Poison Control System.
OBJECTIVE
Dietary supplement (DS)-related adverse events (AEs) reported to the California Poison Control System (CPCS) were studied.


METHODS
The CPCS database was used to search for all telephone calls from consumers concerning DS-related AEs received during the six-month period between April and September 2002. The calls were characterized according to the substance involved, the caller's age (adult or pediatric), and the type of ingestion (accidental or intentional). Each exposure in which symptoms were reported was categorized as involving an AE. Each AE was assessed for severity and causality.


RESULTS
Data on a total of 1183 telephone calls were retrieved, of which 828 calls (70%) met the study's inclusion criteria. DS exposure occurred in 389 adults (47%) and 438 children (53%). DS ingestion was accidental in 360 patients (43%) and intentional in 467 patients (56%). Exposure resulted in an AE in 480 patients (58%). AEs were reported in 353 patients (74%) who ingested products containing ephedra; other exposures frequently involved zinc, kava, creatine, and valerian. AEs were classified as moderate in 198 patients (41%) who ingested a DS and as severe in 40 patients (8%). One patient had a fatal reaction. Among the 480 AEs in DS-exposed consumers, the DS was classified as the definite cause of 1 AE (<1%) and a probable cause of 237 (49.4%). The most frequently reported AE symptoms were increased heart rate (45%), agitation (30%), vomiting (30%), and nausea (15%).


CONCLUSIONS
A majority of DS-related AEs reported by consumers to CPCS involved ephedra-containing products.
Dennehy
Cathi E
CE
School of Pharmacy, University of California San Francisco (UCSF), 94143, USA.
Tsourounis
Candy
C
Horn
Angela J
AJ
D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems; D002140:California / Q000453:epidemiology; D002648:Child; D003625:Data Collection / Q000379:methods; D019587:Dietary Supplements / Q000009:adverse effects* / Q000145:classification / Q000506:poisoning; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000506:poisoning; D029789:Ephedra; D005260:Female; D006801:Humans; D008297:Male; D010946:Plants, Medicinal; D011039:Poison Control Centers; D012189:Retrospective Studies
D004365:Drugs, Chinese Herbal