Amyloid beta 38, 40, and 42 species in cerebrospinal fluid: more of the same?
Various C-terminally truncated amyloid beta peptides (Abeta) are linked to Alzheimer's disease (AD) pathogenesis. Cerebrospinal fluid (CSF) concentrations of Abeta38, Abeta40, and Abeta42 were measured by enzyme-linked immunosorbent assay in 30 patients with AD and 26 control subjects. CSF Abeta42 levels was decreased in patients with AD, whereas CSF Abeta38 and Abeta40 levels were similar in patients with AD and control subjects. All three Abeta peptides were interrelated, particularly CSF Abeta38 and Abeta40. Diagnostic accuracy of CSF Abeta42 concentrations was not improved by applying the ratios of CSF Abeta42 to Abeta38 or Abeta40.
Schoonenboom
Niki S
NS
Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, the Netherlands. niki.schoonenboom@vumc.nl
Mulder
Cees
C
Van Kamp
Gerard J
GJ
Mehta
Sangita P
SP
Scheltens
Philip
P
Blankenstein
Marinus A
MA
Mehta
Pankaj D
PD
D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid*; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity
D016229:Amyloid beta-Peptides; D015415:Biomarkers