No one asked the baby -- an ethical issue in placebo-controlled trials in pregnant smokers.
This case report involving a placebo-controlled nicotine patch trial illustrates the difficult issue of conducting placebo studies in pregnancy, when one of the two patients involved cannot be asked to consent.
Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, University of Toronto.
Peter
P
Selby
Bhushan
B
Kapur
Richard
R
Hackman
Gideon
G
Koren
D000328:Adult; D003367:Cotinine / Q000097:blood*; D005260:Female; D006801:Humans; D007258:Informed Consent; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D016032:Randomized Controlled Trials as Topic / Q000941:ethics*; D016540:Smoking Cessation; D014029:Tobacco Use Disorder / Q000097:blood*
D003367:Cotinine