Successful long-term program for controlling methicillin-resistant Staphylococcus aureus in intensive care units.
OBJECTIVE
To evaluate the effectiveness of screening strategy and contact precautions for patients with methicillin-resistant Staphylococcus aureus (MRSA).


METHODS
Prospective observational cohort from 1 February 1995 to 31 December 2001 in three intensive care units (45 beds) in a French teaching hospital.


METHODS
8,548 patients admitted to the three ICUs had nasal screening on ICU admission and weekly thereafter. Contact precautions were used in MRSA-positive patients. The following variables were collected: age, gender, severity score, length of stay, workload, and colonization pressure (percentage of patient-days with an MRSA to the number of patient-days in the unit). Alcohol-based handrub solution was introduced in July 2000. We compared the period before this (P1) with that thereafter (P2).


RESULTS
Of the 8,548 admitted patients 554 (6.5%) had MRSA at ICU admission, and 456 of the 7,515 (6.1%) exposed patients acquired MRSA. Acquisition incidence decreased from 7.0% in P1 to 2.8% in P2. Independent variables associated with MRSA acquisition were: age (adjusted odds ratio 1.013), severity score (1.047), length of ICU stay (1.015), colonization pressure (1.019), medical ICU (1.58), and P2 (0.49).


CONCLUSIONS
MRSA control in these ICUs characterized by a high prevalence of MRSA at admission was achieved via multiple factors, including screening, contact precautions, and use of alcoholic handrub solution. Our results after adjustment of risk factors for MRSA acquisition and the steady improvement in MRSA over several years strengthen these findings. MRSA spreading can be successfully controlled in ICUs with high colonization pressure.
Lucet
Jean-Christophe
JC
Infection Control Unit, Bichat-Claude Bernard Teaching Hospital, Assistance publique-Hôpitaux de Paris, 75877 Paris Cedex 18, France. jean-christophe.lucet@bch.ap-hop-paris.fr
Paoletti
Xavier
X
Lolom
Isabelle
I
Paugam-Burtz
Catherine
C
Trouillet
Jean-Louis
JL
Timsit
Jean-François
JF
Deblangy
Claude
C
Andremont
Antoine
A
Regnier
Bernard
B
D000328:Adult; D000368:Aged; D000438:Alcohols / Q000494:pharmacology; D015331:Cohort Studies; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*; D005260:Female; D006235:Hand Disinfection / Q000379:methods; D006801:Humans; D015994:Incidence; D007362:Intensive Care Units; D007902:Length of Stay; D008297:Male; D008712:Methicillin / Q000494:pharmacology; D016106:Methicillin Resistance; D008875:Middle Aged; D010297:Paris / Q000453:epidemiology; D011446:Prospective Studies; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification*; D013997:Time Factors; D016896:Treatment Outcome
D000438:Alcohols; D008712:Methicillin