PREDBALB/c: a system for the prediction of peptide binding to H2d molecules, a haplotype of the BALB/c mouse.
PRED(BALB/c) is a computational system that predicts peptides binding to the major histocompatibility complex-2 (H2(d)) of the BALB/c mouse, an important laboratory model organism. The predictions include the complete set of H2(d) class I (H2-K(d), H2-L(d) and H2-D(d)) and class II (I-E(d) and I-A(d)) molecules. The prediction system utilizes quantitative matrices, which were rigorously validated using experimentally determined binders and non-binders and also by in vivo studies using viral proteins. The prediction performance of PRED(BALB/c) is of very high accuracy. To our knowledge, this is the first online server for the prediction of peptides binding to a complete set of major histocompatibility complex molecules in a model organism (H2(d) haplotype). PRED(BALB/c) is available at http://antigen.i2r.a-star.edu.sg/predBalbc/.
Institute for Infocomm Research, 21 Heng Mui Keng Terrace, Singapore 119613.
Guang Lan
GL
Zhang
Kellathur N
KN
Srinivasan
Anitha
A
Veeramani
J Thomas
JT
August
Vladimir
V
Brusic
D000818:Animals; D019295:Computational Biology / Q000379:methods*; D018984:Epitopes, T-Lymphocyte / Q000737:chemistry* / Q000378:metabolism; D006183:H-2 Antigens / Q000235:genetics / Q000378:metabolism*; D006239:Haplotypes; D020407:Internet; D051379:Mice; D008807:Mice, Inbred BALB C / Q000235:genetics / Q000276:immunology*; D010455:Peptides / Q000737:chemistry* / Q000276:immunology* / Q000378:metabolism; D020539:Sequence Analysis, Protein; D012984:Software
D018984:Epitopes, T-Lymphocyte; D006183:H-2 Antigens; D010455:Peptides