Cardioprotection before revascularization in ischemic myocardial injury and the potential role of hemoglobin-based oxygen carriers.
Despite the availability of interventional catheterization for patients with acute coronary syndromes, there is an unavoidable delay until the occluded coronary artery(s) can be revascularized, during which time persistent ischemia may lead to irreversible myocardial damage despite subsequently high patency rates. Accordingly, there has been an intense effort to develop early interventions that will preserve the viability of ischemic myocardium before revascularization. A number of novel strategies have been studied, including hemoglobin-based oxygen carriers. These compounds transport oxygen in the plasma to help maintain more normal oxygen delivery to the myocardium supplied by a thrombosed vessel, and they also release oxygen to tissue more efficiently than intraerythrocytic hemoglobin.
Division of Circulatory Physiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. db59@columbia.edu
Daniel
D
Burkhoff
David J
DJ
Lefer
D000328:Adult; D000368:Aged; D001802:Blood Substitutes / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D017322:Clinical Trials, Phase II as Topic; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D005260:Female; D006454:Hemoglobins / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009203:Myocardial Infarction / Q000188:drug therapy / Q000601:surgery / Q000628:therapy; D017202:Myocardial Ischemia / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control; D009204:Myocardial Revascularization; D009206:Myocardium / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D010865:Pilot Projects; D011300:Preoperative Care; D016032:Randomized Controlled Trials as Topic
D001802:Blood Substitutes; D002316:Cardiotonic Agents; D006454:Hemoglobins; C096798:HBOC 201; D010100:Oxygen