[Anti-H1 in dermatological practice].
BACKGROUND
Histamine is an inflammation mediator that is fundamental for the development of some allergic reactions and is also implied in several common dermatological affections. Anti-H1s are molecules capable of couteracting the effect of histamine on its specific receptors. There are two types: first generation anti-H1 and second generation anti-H1.


OBJECTIVE
To assess the efficacy of anti-H1 in the treatment of skin diseases.


METHODS
A reference search was made using the Pubmed data bank. Critical analysis was made of the articles selected based on their evidence.


CONCLUSIONS
Demonstration of the efficacy of anti-H1 was only confirmed in a few dermatitis. Urticaria is the indication of choice. The symptomatic use of anti-H1 may be justified within the context of other dermatitis. The second rather than the first generation molecules should be preferred because of the lesser side effects and improved pharmacokinetic profile.
Gaudy-Marqueste
C
C
Service de Dermatologie et Vénérologie, Hôpital Sainte Marguerite, 270, boulevard Sainte-Marguerite, 13009 Marseille.
Grob
J-J
JJ
Richard
M-A
MA
D003872:Dermatitis / Q000188:drug therapy* / Q000276:immunology; D006632:Histamine / Q000378:metabolism; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation; D014581:Urticaria / Q000188:drug therapy* / Q000276:immunology
D006634:Histamine H1 Antagonists; D006632:Histamine