Treatment of Gorham's disease with zoledronic acid.
Gorham's disease (GD) is a rare disorder characterized by spontaneous and progressive osteolysis of one or more bones and thought to belong to lymphangiomatoses spectrum of diseases. Surgical, radiation and medical therapies have been performed with variable and often discouraging outcomes and currently there is no recognized effective treatment. In this paper we describe a 24-year-old girl with GD localized to mandible who was effectively managed with zoledronic acid, a nitrogen-containing high-potency bisphosphonate.
Oral Medicine Division, Department of Odontostomatological and Maxillofacial Sciences, University Federico II of Naples, Via Pansini 5, 80129 Naples, Italy. mignogna@unina.it
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MD
Mignogna
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S
Fedele
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L
Lo Russo
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R
Ciccarelli
D000328:Adult; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D008336:Mandibular Diseases / Q000188:drug therapy*; D010015:Osteolysis, Essential / Q000188:drug therapy*; D016896:Treatment Outcome; D000077211:Zoledronic Acid
D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid