A novel synthesis and molluscicidal activity of some functionally substituted pyridine, pyrido[3,2-c]pyridazine, and pyrido[3,2-c]pyridazino[2',3'-a]quinazoline derivatives.
Ethyl benzoylacetate reacts with the malononitrile dimer to afford 4-amino-5-benzoyl-2-dicyano methyl-6-hydroxypyridine, which undergoes the coupling reaction with aromatic diazonium salts to afford azo derivatives. These azo derivatives could be cyclized into pyrido[3,2-c]pyridazine and pyrido[3,2-c]pyridazino[2',3'-a]quinazoline derivatives upon reflux in ethanolic NaOH, presumably via their hydrazo tautomers. The molluscicidal activity of these compounds was evaluated.
Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt. prof_fmrazek@yahoo.com
Fathy M
FM
Abdelrazek
Alaa El-Din M
Ael-D
Fathy
D000818:Animals; D001700:Biomphalaria / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007536:Isomerism; D008975:Molluscacides / Q000138:chemical synthesis* / Q000633:toxicity; D011724:Pyridazines / Q000138:chemical synthesis* / Q000633:toxicity; D011725:Pyridines / Q000138:chemical synthesis* / Q000633:toxicity; D021281:Quantitative Structure-Activity Relationship; D011799:Quinazolines / Q000138:chemical synthesis* / Q000633:toxicity; D023382:Toxicity Tests, Acute / Q000379:methods
D008975:Molluscacides; D011724:Pyridazines; D011725:Pyridines; D011799:Quinazolines