Get a grip: integrins in cell-biomaterial interactions.
Integrin adhesion receptors have emerged as central regulators of cell-biomaterial interactions. This opinion paper discusses how integrins control cellular and host responses to biomaterials and new strategies to manipulate these adhesive interactions in order to elicit specific cellular responses.
Woodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA 30332-0363, USA. andres.garcia@me.gatech.edu
Andrés J
AJ
García
D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002448:Cell Adhesion; D006801:Humans; D007249:Inflammation; D016023:Integrins / Q000378:metabolism*; D008954:Models, Biological; D009842:Oligopeptides / Q000737:chemistry; D034622:RNA Interference; D015398:Signal Transduction; D013499:Surface Properties
D001672:Biocompatible Materials; D016023:Integrins; D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid