Mortality in dementia.
The objective of this work is to provide a review of the mortality risk in dementia and potential influencing factors. In order to do so, studies on mortality in dementia based on population-based samples of the last 15 years published in PubMed, Web of Science and PSYNDEXplus were considered. Without exception, all types of dementia are associated with a considerably increased mortality risk. Moreover, the risk of death rises with advancing severity of the disorder. Often, a more favorable course of the disease can be found in Alzheimer's disease. Further questions, such as the influence of age and sex, cannot be answered conclusively. Very little information can be found on aspects concerning comorbidity, APOE polymorphism or depressive symptomatology.
Klinik und Poliklinik fur Psychiatrie der Universitat Leipzig, Deutschland. uta.guehne@medizin.uni-leipzig.de
Uta
U
Guehne
Steffi
S
Riedel-Heller
Matthias C
MC
Angermeyer
D000367:Age Factors; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000097:blood; D003704:Dementia / Q000097:blood / Q000209:etiology / Q000401:mortality*; D005260:Female; D006801:Humans; D008017:Life Expectancy; D008297:Male; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors; D012959:Socioeconomic Factors
D053327:Apolipoprotein E4; D001057:Apolipoproteins E