Effects of oral vitamin C supplementation on oxidative stress and inflammation status in haemodialysis patients.
BACKGROUND
There is increasing evidence for the presence of oxidative stress and vitamin C deficiency in dialysis patients. Limited data, however, are available regarding the effects of vitamin C supplementation on oxidative stress and inflammation markers in such patients.


METHODS
We ran a prospective, randomized, open-label trial to assess the effects of oral vitamin C supplementation (250 mg three times per week) for 2 months on well-defined oxidative and inflammatory markers in 33 chronic haemodialysis (HD) patients.


RESULTS
Normalization of plasma total vitamin C and ascorbate levels by oral vitamin C supplementation did not modify plasma levels of carbonyls, C-reactive protein and albumin, or erythrocyte concentrations of reduced and oxidized glutathione.


CONCLUSIONS
Short-term oral vitamin C supplementation did not modify well-defined oxidative/antioxidative stress and inflammation markers in HD patients. Whether a higher oral dose or the intravenous route can modify these markers remains to be determined.
AURA Centre Henri Küntziger, INSERM ERI-12, Amiens University Hospital and University of Picardie, Amiens, France.
Christine
C
Fumeron
Thao
T
Nguyen-Khoa
Claudine
C
Saltiel
Messeret
M
Kebede
Claude
C
Buisson
Tilman B
TB
Drüeke
Bernard
B
Lacour
Ziad A
ZA
Massy
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000378:metabolism; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D019587:Dietary Supplements; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D007501:Iron / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D006435:Renal Dialysis; D012907:Smoking
D000975:Antioxidants; D006454:Hemoglobins; D007501:Iron; D001205:Ascorbic Acid