Role of motility and flagellin glycosylation in the pathogenesis of Pseudomonas aeruginosa burn wound infections.
In this study, we tested the contribution of flagellar motility, flagellin structure, and its glycosylation in Pseudomonas aeruginosa using genetically defined flagellar mutants. All mutants and their parent strains were tested in a burned-mouse model of infection. Motility and glycosylation of the flagellum appear to be important determinants of flagellar-mediated virulence in this model. This is the first report where genetically defined flagellar variants of P. aeruginosa were tested in the burned-mouse model of infection.
Department of Medicine/Infectious Diseases, P.O. Box 100277, University of Florida, Gainesville, Florida 32610, USA.
Shiwani K
SK
Arora
Alice N
AN
Neely
Barbara
B
Blair
Stephen
S
Lory
Reuben
R
Ramphal
D000818:Animals; D002056:Burns / Q000150:complications*; D005408:Flagellin / Q000737:chemistry / Q000378:metabolism*; D006031:Glycosylation; D007928:Lethal Dose 50; D051379:Mice; D009068:Movement; D011552:Pseudomonas Infections / Q000209:etiology*; D011550:Pseudomonas aeruginosa / Q000472:pathogenicity*; D014946:Wound Infection / Q000209:etiology*
D005408:Flagellin