[Association study of the Ile50Val polymorphism of interleukin-4 receptor gene (IL4RA) with chronic viral hepatitis].
The study was performed to estimate association of the Ile50Val polymorphism in IL4RA and clinical characteristics of chronic viral hepatitis including course of disease manifestation which is determined by degree of hepatic fibrosis. The group under investigation included 61 patient diagnosed with chronic viral hepatitis. Control group consisted of 128 randomly selected inhabitants of Tomsk city. Genotyping of Ile50Val polymorphism in the groups was performed by RFLP (restriction fragment length polymorphism) analysis. There was no significant differences in genotypes and alleles frequencies between cases and controls. However differences in genotype distribution depend on fibrosis stage were detected. Ile/Val heterozygote frequency in subgroup of patients without hepatic fibrosis was lower (7.1%) than in controls (51.6%) (p = 0.002) due to increase of both homozygote classes. Subgroup of patients without hepatic fibrosis differed by genotype frequencies both from patients with moderate and severe disease stage (p = 0.035; p = 0.004).
Goncharova
I A
IA
Freĭdin
M B
MB
Dunaeva
L E
LE
Beloborodova
E V
EV
Beloborodova
E V
EV
Puzyrev
V P
VP
D000293:Adolescent; D000328:Adult; D019943:Amino Acid Substitution / Q000235:genetics*; D005260:Female; D005355:Fibrosis / Q000235:genetics / Q000473:pathology; D020022:Genetic Predisposition to Disease; D019694:Hepatitis B, Chronic / Q000235:genetics* / Q000473:pathology; D019698:Hepatitis C, Chronic / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D019948:Receptors, Interleukin-4 / Q000235:genetics*
D019948:Receptors, Interleukin-4