Protective antibodies and endemic dimorphic fungi.
The host response to infection is the outcome of a complex interaction between a microbe and a host's innate and adaptive immune system. In this context, the role of antibody in the endemic mycoses is relatively poorly understood. Recently, a monoclonal antibody to a cell surface protein has been shown to be protective in a murine histoplasmosis model. The findings with Histoplasma capsulatum may provide a paradigm for antibody protection against endemic fungi. This paper reviews the recent data on protective antibody in histoplasmosis and previous data supporting a role for antibody in protective responses in other dimorphic fungi.
Nosanchuk
J D
JD
Department of Medicine, Division of Infectious diseases, Albert Einstein College of Medicine, Bronx, New York 10461, USA. nosanchu@aecom.yu.edu
D000818:Animals; D000908:Antibodies, Fungal / Q000276:immunology* / Q000648:ultrastructure; D000911:Antibodies, Monoclonal / Q000276:immunology* / Q000648:ultrastructure; D006657:Histones / Q000276:immunology / Q000648:ultrastructure; D006658:Histoplasma / Q000276:immunology* / Q000648:ultrastructure; D006660:Histoplasmosis / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D007111:Immunity, Cellular
D000908:Antibodies, Fungal; D000911:Antibodies, Monoclonal; D006657:Histones