Viral evasion of NK-cell activation.
Viruses, such as human cytomegalovirus (HCMV), have developed mechanisms to evade recognition by, and activation of, natural killer (NK) cells, which are cells that provide crucial innate immune defense. Such mechanisms help viruses persist in the human host and attain a state of chronic infection. A recent report documents an antagonistic effect of the main HCMV tegument protein, pp65, on NKp30, a natural cytotoxicity-inducing receptor expressed uniquely on NK cells.
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA.
Sumati
S
Rajagopalan
Eric O
EO
Long
D000818:Animals; D003587:Cytomegalovirus / Q000502:physiology*; D003586:Cytomegalovirus Infections / Q000276:immunology* / Q000378:metabolism / Q000821:virology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology* / Q000821:virology*; D008213:Lymphocyte Activation / Q000276:immunology*; D010750:Phosphoproteins / Q000378:metabolism; D014763:Viral Matrix Proteins / Q000378:metabolism
D010750:Phosphoproteins; D014763:Viral Matrix Proteins; C065418:cytomegalovirus matrix protein 65kDa