[Changes of physiological intraocular pressure (IOP) in rabbits after administration of the amino acid lysine and the antiglaucoma drug latanoprost (Xalatan)].
OBJECTIVE
To show and underline specific character of influence of the mixture of 10% L-lysine.2HCl.2H2O in 0.005% latanoprost on physiological levels of IOP.


METHODS
The mixture of 10% L-lysine.2HCl.2H2O in 0.005 % latanoprost (Xalatan), or separately 0.005 % latanoprost and 10% L-lysine.2HCl.2H2O respectively were in weekly intervals instilled into the conjunctival sac of the left eye of five rabbits (females of "New Zealand white" bred). The IOP levels and the size of the pupil were measured in minute 5, 15, 30, 60, 120, 180, and 240 after the instillation. The right eye was considered as a control.


RESULTS
The amino acid L-lysine.2HCl.2H2O by itself did not influence the IOP or the size of the pupil; latanoprost until minute 30 lowered the IOP, in minute 55 exceeds the IOP the level of the control eye. Since minute 60 until 240, the IOP changed irregularly and insignificantly. The mixture of 10% solution of L-lysine.2HCl.2H2O in latanoprost 0.005% insignificantly lowered the IOP until min. 30, after rapid elevation in min. 50 exceeds the IOP of the control eye, and since min. 60, the IOP remains above the control eye's IOP with the same course of levels.


CONCLUSIONS
The amino acid L-lysine.2HCl.2H2O alone did not change the physiological IOP. Latanoprost 0.005% significantly lowered the IOP until min. 30. High level of interactive specificity as well as duration of influence of the mixture of respective amino acid with respective antiglaucomatic drug was established.
Oláh
Z
Z
Klinika oftalmológie LF UK, Bratislava>
Veselovský
J
J
Gressnerová
S
S
Veselá
A
A
D000818:Animals; D004338:Drug Combinations; D005260:Female; D005901:Glaucoma / Q000188:drug therapy; D007429:Intraocular Pressure / Q000187:drug effects*; D000077338:Latanoprost; D008239:Lysine / Q000008:administration & dosage / Q000494:pharmacology*; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits
D004338:Drug Combinations; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost; D008239:Lysine