pain1: a neuropathic pain QTL on mouse chromosome 15 in a C3HxC58 backcross.
We have produced a backcross (BC) population of 267 mice from the parental strains C3H/HeN and C58/J. The mice were phenotyped for neuropathic pain using the neuroma model. Subsequently all BC mice were genotyped in a region of chromosome 15 that has been previously suggested to contain a quantitative trait locus (QTL) for this trait. We have confirmed the linkage of the QTL, named pain1, to the central region of chromosome 15. Our finding provides the necessary robustness to justify efforts towards identification of the underlying gene.
Devor
Marshall
M
Department of Cell and Animal Biology, and Center for Research on Pain, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem 91904, Israel Department of Genetics, Institute of Life Sciences, Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel Department of Statistics, Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Gilad
Amit
A
Arbilly
Michal
M
Yakir
Benjamin
B
Raber
Pnina
P
Pisanté
Anne
A
Darvasi
Ariel
A
D000818:Animals; D002874:Chromosome Mapping; D002875:Chromosomes; D020022:Genetic Predisposition to Disease; D005838:Genotype; D007178:Inbreeding; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D008815:Mice, Inbred Strains; D010146:Pain / Q000235:genetics*; D010641:Phenotype; D040641:Quantitative Trait Loci / Q000235:genetics*
D008565:Membrane Proteins