A twist in anti-inflammation: annexin 1 acts via the lipoxin A4 receptor.
The inflammatory response is a life-saving protective process mounted by the body to overcome pathogen infection and injury; however, in chronic inflammatory pathologies this response can become deregulated. The existence of specialized anti-inflammatory pathways/mediators that operate in the body to down-regulate inflammation have now emerged. Thus, persistence of inflammation leading to pathology could be due to malfunctioning of one or more of these counter-regulatory pathways. Here we focus on one of them, the anti-inflammatory mediator annexin 1, and provide an update on its inhibitory effects upon the leukocyte trafficking process. In particular, recent evidence that receptors of the formyl-peptide family, which includes also the lipoxin A4 receptor, could be the annexin 1 receptor(s) in the context of anti-inflammation might provide new avenues for exploiting this pathway for drug discovery.
Gavins
F N E
FN
Centre for Biochemical Pharmacology, William Harvey Research Institute, Bart's and The London, Queen Mary School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK.
Sawmynaden
P
P
Chatterjee
B E
BE
Perretti
M
M
D000818:Animals; D017305:Annexin A1 / Q000502:physiology*; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology*; D018836:Inflammation Mediators / Q000502:physiology*; D007962:Leukocytes / Q000502:physiology; D044045:Lipoxins / Q000502:physiology; D051379:Mice; D008817:Mice, Mutant Strains; D009203:Myocardial Infarction / Q000503:physiopathology; D044067:Receptors, Lipoxin / Q000502:physiology; D018000:Receptors, Peptide
D017305:Annexin A1; D018836:Inflammation Mediators; D044045:Lipoxins; D044067:Receptors, Lipoxin; D018000:Receptors, Peptide; C040527:lipoxin A4