Neuroprotective effects of naturally occurring biflavonoids.
We examined neuroprotective effects of naturally occurring biflavonoids on oxidative stress-induced and amyloid beta peptide-induced cell death in neuronal cells. Among the nine biflavonoids tested, amentoflavone, ginkgetin, and isoginkgetin exhibited strong neuroprotection against cytotoxic insults induced by oxidative stress and amyloid beta, suggesting their therapeutic potential against neurodegenerative diseases, including ischemic stroke and Alzheimer's disease.
Department of Manufacturing Pharmacy, Seoul National University College of Pharmacy, Seoul 110-460, Republic of Korea.
Sam Sik
SS
Kang
Ji Yeon
JY
Lee
Yoo Keum
YK
Choi
Sun Sook
SS
Song
Ju Sun
JS
Kim
Su Jin
SJ
Jeon
Yong Nam
YN
Han
Kun Ho
KH
Son
Byung Hee
BH
Han
D000544:Alzheimer Disease / Q000188:drug therapy; D016229:Amyloid beta-Peptides / Q000378:metabolism / Q000494:pharmacology; D044946:Biflavonoids / Q000737:chemistry / Q000494:pharmacology*; D002545:Brain Ischemia / Q000188:drug therapy; D016923:Cell Death / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D019636:Neurodegenerative Diseases / Q000188:drug therapy; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*; D014407:Tumor Cells, Cultured
D016229:Amyloid beta-Peptides; D044946:Biflavonoids; D018696:Neuroprotective Agents