Catalytic Pictet-Spengler reactions using Yb(OTf)3.
The catalytic Pictet-Spengler reactions proceeded in high yields with high regioselectivity in the presence of a catalytic amount of Yb(OTf)3 and a dehydrating agent at room temperature. High regioselectivities were obtained in these reactions, and it is suggested that the reactions proceeded under kinetic control.
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Kei
K
Manabe
Daisuke
D
Nobutou
Shū
S
Kobayashi
D002384:Catalysis; D007546:Isoquinolines / Q000737:chemistry; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015018:Ytterbium / Q000737:chemistry*
D007546:Isoquinolines; D015018:Ytterbium