Carcinoid crisis after injection of 6-18F-fluorodihydroxyphenylalanine in a patient with metastatic carcinoid.
A carcinoid crisis is a severe complication of the carcinoid syndrome that can arise in patients with advanced metastatic neuroendocrine tumors. It can be initiated by stress, catecholamines, and tumor manipulation. In this article, we report a case in which an injection with the catecholamine tracer 6-18F-fluorodihydroxyphenylalanine, used for PET, induced a carcinoid crisis. Octreotide can be used for treatment and should be available. Tracer injection should be slow.
Department of Nuclear Medicine and PET Center, University Medical Center Groningen, Groningen, The Netherlands.
Klaas P
KP
Koopmans
Adrienne H
AH
Brouwers
Marjolijn N
MN
De Hooge
Anouk N
AN
Van der Horst-Schrivers
Ido P
IP
Kema
Bruce H
BH
Wolffenbuttel
Elisabeth G
EG
De Vries
Pieter L
PL
Jager
D004295:Dihydroxyphenylalanine / Q000009:adverse effects* / Q000031:analogs & derivatives*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy; D006801:Humans; D007275:Injections, Intravenous / Q000009:adverse effects; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D008303:Malignant Carcinoid Syndrome / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000009:adverse effects
D019275:Radiopharmaceuticals; C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine; D015282:Octreotide