[Investigation on the therapeutic effect of carbamazepine on the mood disorders in Japan].
A history of investigation on the mood stabilizing effect of carbamazepine in Japan was described. Following the initial open trials in the early 1970s in which the antimanic and prophylactic effects of carbamazepine were demonstrated on a large number of patients for the first time in the world, the mood stabilizing effect was confirmed by our double-blind study comparing carbamazepine vs chlorpromazine in the late 1970s and that comparing carbamazepine and lithium in late 1980s which were performed with multi-institutional cooperation in Japan. The studies on carbamazepine in the early 1970s in Japan stimulated the study on the mood stabilizing effect of antiepileptic drugs in the world and contributed to the establishment of the criteria "mood-stabilizers". The similarities and differences of responders for carbamazepine and lithium and effect of combination therapy of carbamazepine and lithium were also studied by our research group in Tottori University.
National Center of Neurology and Psychiatry, Okuma Clinic.
Teruo
T
Okuma
D000928:Antidepressive Agents / Q000627:therapeutic use*; D002220:Carbamazepine / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D007564:Japan; D008094:Lithium / Q000008:administration & dosage; D019964:Mood Disorders / Q000188:drug therapy*
D000928:Antidepressive Agents; D002220:Carbamazepine; D008094:Lithium