No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples.
BACKGROUND
It has been recently reported that a functional variant in the ZDHHC8 gene encoding a putative palmitoyltransferase directly confers susceptibility to schizophrenia in females ().


METHODS
We investigated the putative risk allele (rs175174) in four schizophrenia association samples including a Bulgarian proband and parent sample (474 trios) and three case-control panels of European origin (1028 patients/1253 control subjects) in an attempt to replicate these findings.


RESULTS
Our results do not support the hypothesis that genetic variation at rs175174 is associated with increased risk for schizophrenia nor do they suggest the presence of gender-specific differences.


CONCLUSIONS
Our data suggest that the reported genetic association by either represents type I error resulting from sampling variance or that rs175174 is in linkage disequilibrium (LD) with the functional variant for schizophrenia and different LD patterns obscure the detection of association.
Department of Psychological Medicine, Cardiff University, Cardiff, United Kingdom.
Beate
B
Glaser
Johannes
J
Schumacher
Hywel J
HJ
Williams
Rami Abou
RA
Jamra
Nikolai
N
Ianakiev
Radoi
R
Milev
Stephanie
S
Ohlraun
Thomas G
TG
Schulze
Piotr M
PM
Czerski
Joanna
J
Hauser
Erick G
EG
Jönsson
Göran C
GC
Sedvall
Norman
N
Klopp
Thomas
T
Illig
Tim
T
Becker
Peter
P
Propping
Nigel M
NM
Williams
Sven
S
Cichon
George
G
Kirov
Marcella
M
Rietschel
Kieran C
KC
Murphy
Michael C
MC
O'Donovan
Markus M
MM
Nöthen
Michael J
MJ
Owen
D000217:Acyltransferases / Q000235:genetics*; D000483:Alleles; D002031:Bulgaria / Q000208:ethnology; D002648:Child; D002892:Chromosomes, Human, Pair 22; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D014644:Genetic Variation; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012307:Risk Factors; D012559:Schizophrenia / Q000201:enzymology / Q000235:genetics*; D012737:Sex Factors; D044465:White People / Q000235:genetics*; D016335:Zinc Fingers / Q000235:genetics
D008565:Membrane Proteins; D000217:Acyltransferases; C488097:ZDHHC8 protein, human