[Research advances on drug resistance and anti-apoptosis of leukemic cells associated with bone marrow stromal cells--review].
The bone marrow microenvironment composed of bone marrow cell, their secreted cytokines and extra-cellular medium (ECM), plays an important role in the process of hematopoiesis, hematonosis, apoptosis of malignant blood cells. In this review, the mechanisms for the protection of the leukemiic cells from the drug-induced apoptosis by bone marrow stromal cells and the related progress were summarized.
Department of Hematology, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China.
Zhong-Jun
ZJ
Li
Xing-Hua
XH
Chen
D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism; D001854:Bone Marrow Cells / Q000378:metabolism / Q000473:pathology*; D019008:Drug Resistance, Neoplasm; D006801:Humans; D007938:Leukemia / Q000378:metabolism / Q000473:pathology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology*
D051017:Apoptosis Regulatory Proteins; D019253:Proto-Oncogene Proteins c-bcl-2