Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes.
We report the genome sequence of Theileria parva, an apicomplexan pathogen causing economic losses to smallholder farmers in Africa. The parasite chromosomes exhibit limited conservation of gene synteny with Plasmodium falciparum, and its plastid-like genome represents the first example where all apicoplast genes are encoded on one DNA strand. We tentatively identify proteins that facilitate parasite segregation during host cell cytokinesis and contribute to persistent infection of transformed host cells. Several biosynthetic pathways are incomplete or absent, suggesting substantial metabolic dependence on the host cell. One protein family that may generate parasite antigenic diversity is not telomere-associated.
Gardner
Malcolm J
MJ
Institute for Genomic Research (TIGR), 9712 Medical Center Drive, Rockville, MD 20850, USA. gardner@tigr.org
Bishop
Richard
R
Shah
Trushar
T
de Villiers
Etienne P
EP
Carlton
Jane M
JM
Hall
Neil
N
Ren
Qinghu
Q
Paulsen
Ian T
IT
Pain
Arnab
A
Berriman
Matthew
M
Wilson
Robert J M
RJ
Sato
Shigeharu
S
Ralph
Stuart A
SA
Mann
David J
DJ
Xiong
Zikai
Z
Shallom
Shamira J
SJ
Weidman
Janice
J
Jiang
Lingxia
L
Lynn
Jeffery
J
Weaver
Bruce
B
Shoaibi
Azadeh
A
Domingo
Alexander R
AR
Wasawo
Delia
D
Crabtree
Jonathan
J
Wortman
Jennifer R
JR
Haas
Brian
B
Angiuoli
Samuel V
SV
Creasy
Todd H
TH
Lu
Charles
C
Suh
Bernard
B
Silva
Joana C
JC
Utterback
Teresa R
TR
Feldblyum
Tamara V
TV
Pertea
Mihaela
M
Allen
Jonathan
J
Nierman
William C
WC
Taracha
Evans L N
EL
Salzberg
Steven L
SL
White
Owen R
OR
Fitzhugh
Henry A
HA
Morzaria
Subhash
S
Venter
J Craig
JC
Fraser
Claire M
CM
Nene
Vishvanath
V
D000465:Algorithms; D000818:Animals; D000953:Antigens, Protozoan / Q000235:genetics; D002417:Cattle; D049109:Cell Proliferation; D002875:Chromosomes / Q000235:genetics; D017124:Conserved Sequence; D004798:Enzymes / Q000235:genetics / Q000378:metabolism; D017125:Genes, Protozoan; D018503:Genome, Protozoan; D008214:Lymphocytes / Q000166:cytology / Q000469:parasitology*; D008928:Mitochondria / Q000378:metabolism; D008969:Molecular Sequence Data; D015388:Organelles / Q000235:genetics / Q000502:physiology; D010963:Plasmodium falciparum / Q000235:genetics; D017434:Protein Structure, Tertiary; D015800:Protozoan Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D017422:Sequence Analysis, DNA; D026801:Synteny; D016615:Telomere / Q000235:genetics; D016797:Theileria parva / Q000235:genetics* / Q000254:growth & development / Q000472:pathogenicity / Q000502:physiology
D000953:Antigens, Protozoan; D004798:Enzymes; D015800:Protozoan Proteins