Combined detection of Chlamydia trachomatis-specific antibodies against the 10 and 60-kDa heat shock proteins as a diagnostic tool for tubal factor infertility: Results from a case-control study in Cameroon.
A case-control study was conducted to determine the diagnostic value of Chlamydia trachomatis-associated anti-Chsp10 and/or anti-Chsp60 antibodies in the detection of secondary infertility. There were significant associations between C. trachomatis infection and infertility (p<0.01), and between C. trachomatis-specific anti-Chsp10 or anti-Chsp60 antibodies and secondary infertility (p<0.001). A significant correlation was found between anti-Chsp10 and anti-Chsp60 titers (p<0.01). The detection of either C. trachomatis-associated anti-Chsp10 or anti-Chsp60 antibodies cumulatively allowed specific diagnosis of secondary infertility (57.4% sensitivity, 75.5% specificity).
Dadamessi
Innocenti
I
Department of Medicine, Centre Hospitalier de Péronne, France.
Eb
François
F
Betsou
Fotini
F
D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D002163:Cameroon / Q000453:epidemiology; D016022:Case-Control Studies; D018835:Chaperonin 10 / Q000276:immunology; D018834:Chaperonin 60 / Q000276:immunology; D002690:Chlamydia Infections / Q000150:complications* / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D002692:Chlamydia trachomatis / Q000276:immunology*; D005260:Female; D006360:Heat-Shock Proteins / Q000276:immunology; D006801:Humans; D007247:Infertility, Female / Q000209:etiology*; D008875:Middle Aged; D011247:Pregnancy; D016036:Seroepidemiologic Studies
D000907:Antibodies, Bacterial; D018835:Chaperonin 10; D018834:Chaperonin 60; D006360:Heat-Shock Proteins