Grayanane diterpenoids from the flowers of Rhododendron molle with cytotoxic activity against a Spodoptera frugiperda cell line.
Two new grayanane diterpenoids, rhodomolins A (1) and B (2), together with two known diterpenoids, rhodomolleins I and rhodojaponin III, were isolated from the flowers of Rhododendron molle. The structures of 1 and 2 were elucidated on the basis of interpretation of spectroscopic data. All compounds were evaluated for cytotoxic activity against the Spodoptera frugiperda cell line Sf-9 and gave IC(50) values in the range 12-80 microg/mL.
Laboratory of Insect Toxicology, South China Agricultural University and Key Laboratory of Pesticides and Chemical Biology, Ministry of Education of the People's Republic of China, Guangzhou.
Guohua
G
Zhong
Meiying
M
Hu
Xiaoyi
X
Wei
Qunfang
Q
Weng
Jianjun
J
Xie
Jingxiang
J
Liu
Wenxiang
W
Wang
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D035264:Flowers / Q000737:chemistry; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D029793:Rhododendron / Q000737:chemistry*; D018411:Spodoptera / Q000166:cytology / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C502677:rhodomolin A; C502678:rhodomolin B; C069462:rhodomollein III