Aortic dissection--an update.
Acute aortic dissection is a medical emergency with high morbidity and mortality requiring emergent diagnosis and therapy. Rapid advances in noninvasive imaging technology have facilitated the early diagnosis of this condition and should be considered in the differential diagnosis of any patient with chest, back, or abdominal pain. Emergent surgery is the treatment for patients with type A dissection while optimal medical therapy is appropriate in patients with uncomplicated type B dissection. Adequate beta-blockade is the cornerstone of medical therapy. Patients who survive acute aortic dissection need long-term medical therapy with beta-blockers and statins and appropriate serial imaging follow-up. Future advances in this field include biomarkers in the early diagnosis of acute aortic dissection and presymptomatic diagnosis with genetic screening. Overall patients with aortic dissection are at high risk for an adverse outcome and need to be managed aggressively in hospital and long term with frequent follow-up.
Cardiac Catheterization Laboratories, University of Kentucky, KY, USA.
Debabrata
D
Mukherjee
Kim A
KA
Eagle
D000208:Acute Disease; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000784:Aortic Dissection / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery; D001014:Aortic Aneurysm / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery; D015415:Biomarkers; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging / Q000379:methods; D004535:Ehlers-Danlos Syndrome; D006801:Humans; D008382:Marfan Syndrome; D013577:Syndrome
D000319:Adrenergic beta-Antagonists; D015415:Biomarkers; D002121:Calcium Channel Blockers