Immunosurveillance by gammadelta T cells: focus on the murine system.
Physiologic immune responses are an integration of the activities of several lymphoid cell types that include qualitatively distinct T cell subsets. The contributions that specific T cell subsets make during infection, inflammation, and carcinogenesis is becoming increasingly clear from a variety of mouse models and, importantly, their backcrossing onto different genetic backgrounds. This review considers what we have learned in the mouse about the crucial roles played by gammadelta T cells. We consider how the cells' associations with specific tissues have revealed that T cell responses are regulated locally as well as systemically, and we discuss the implications of this for understanding and enhancing immune surveillance in the clinical setting.
Girardi
Michael
M
Department of Dermatology, Yale University School of Medicine, New Haven, Conn., USA.
Hayday
Adrian C
AC
D000818:Animals; D006801:Humans; D051379:Mice; D018448:Models, Immunological; D009374:Neoplasms, Experimental / Q000276:immunology; D009375:Neoplasms, Glandular and Epithelial / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000378:metabolism*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D016692:Receptors, Antigen, T-Cell, gamma-delta