[Progress of research on epigenetic and human disease.].
In the past few fears, there has been a nascent convergence of scientific understanding of human disease with epigenetic. Identified epigenetic processes involved in human disease include chromatin remodeling, genomic imprinting, X chromosome inactivation, and noncoding RNAs regulation. These processes influence chromatin structure and thereby regulate gene expression on the chromosome level or a cluster of linked genes level. Deregulation of these processes result in lots of disease which are characterized by complex patterns of mutations and associated phenotypes affecting pre- and postnatal growth, development, and neurological function. Epigenetic diseases are illustrated by the array of multi-system disorders and neoplasias and investigations of these diseases have an impact on biomedical research and provide interesting models for functions and mechanisms of epigenetic gene control.
Zhang
Yong-Biao
YB
Department of Genetics, Institute of Medical Biology, Peking Union Medical College, Kunming 650118, China, Email: z_lu_er@sohu,com.
Chu
Jia-You
JY
D042002:Chromatin Assembly and Disassembly; D044127:Epigenesis, Genetic; D057890:Epigenomics; D018392:Genomic Imprinting; D006801:Humans; D022661:RNA, Untranslated
D022661:RNA, Untranslated