[RT-PCR-based evaluation of the activity of human papilloma virus infection in relapsing papillomatosis of the larynx].
RT-PCR-based examination of papilloma samples obtained from patients with relapsing papillomatosis of the larynx showed an incidence rate of human papilloma virus (HPV) amounting to 89%. The viral load level of the studied samples, when measured by concurrent RT-PCR HPV, differed by more than 130 times. It made, in the untreated patient, 1.2 x 10(9) hormonal equivalents/ml, i.e. 13-fold higher versus the patient who received pathogenetic therapy. Thus, the approach in question provides for a possibility to monitor the activity of papilloma viral infection and to evaluate the efficiency of different variations of pathogenetic therapy because the "classic" variant of PCR-detection is not informative in the discussed case.
Manzeniuk
O Iu
OIu
Ashurov
Z M
ZM
Moskalets
O V
OV
Kadyrova
E V
EV
Sloeva
A I
AI
D006801:Humans; D007822:Laryngeal Neoplasms / Q000821:virology*; D009364:Neoplasm Recurrence, Local / Q000821:virology*; D010212:Papilloma / Q000821:virology*; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000821:virology*; D012367:RNA, Viral / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D019562:Viral Load
D012367:RNA, Viral