No effect of interleukin-2 on IgE levels given in addition to antiretroviral therapy in HIV-infected adults with CD4 >300 cells/mm3.
HIV-infected patients may have frequent atopy caused by an imbalance of Th1 and Th2 cytokines. The objective of the present study was to investigate whether IL-2 given in addition to antiretrovirals (ARV) would result in lower IgE levels and less allergic symptoms. Patients naive to IL-2 (n=28) began IL-2 plus ARV and were followed for 12 months. IgE, eosinophil and CD4 counts, HIV RNA, symptom scoring, PFT and skin prick test (SPT) were performed. It was found that the baseline median CD4 and IgE were 386.5 cells/mm3 and 63.5 IU/ml, respectively. Four patients had allergic rhinitis (AR) and 61% had a positive SPT to at least 1 antigen. At month 12, patients had higher CD4 counts (p < 0.001) compared to the baseline; however, there were no differences in IgE levels, allergic symptom scores or HIV RNA. The eosinophil count was higher after IL-2 administration. It was concluded that IL-2 plus ARV resulted in higher CD4 counts but had no effect on atopy.
Ananworanich
Jintanat
J
The HIV Netherlands Australia Thailand Research Colaboration, Thailand. jintanat.a@chula.ac.th
Chantaphakul
Hiroshi
H
Teeratakulpisarn
Somsong
S
Siangphoe
Umaporn
U
Ubolyam
Sasiwimol
S
Chuenyam
Theshinee
T
Ungsedhaphan
Chaiwat
C
Lange
Joep
J
Cooper
David
D
Phanuphak
Praphan
P
Ruxrungtham
Kiat
K
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D004359:Drug Therapy, Combination; D005260:Female; D006678:HIV; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007376:Interleukin-2 / Q000627:therapeutic use*; D008297:Male; D012367:RNA, Viral / Q000097:blood; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy* / Q000453:epidemiology / Q000276:immunology
D019380:Anti-HIV Agents; D007376:Interleukin-2; D012367:RNA, Viral; D007073:Immunoglobulin E