How noise and coupling induce bursting action potentials in pancreatic {beta}-cells.
Unlike isolated beta-cells, which usually produce continuous spikes or fast and irregular bursts, electrically coupled beta-cells are apt to exhibit robust bursting action potentials. We consider the noise induced by thermal fluctuations as well as that by channel-gating stochasticity and examine its effects on the action potential behavior of the beta-cell model. It is observed numerically that such noise in general helps single cells to produce a variety of electrical activities. In addition, we also probe coupling via gap junctions between neighboring cells, with heterogeneity induced by noise, to find that it enhances regular bursts.
Department of Physics, Seoul National University, Seoul, Korea.
Junghyo
J
Jo
Hyuk
H
Kang
Moo Young
MY
Choi
Duk-Su
DS
Koh
D000200:Action Potentials; D000465:Algorithms; D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D004594:Electrophysiology; D017629:Gap Junctions / Q000378:metabolism; D006358:Hot Temperature; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D007477:Ions; D008564:Membrane Potentials; D008954:Models, Biological; D015233:Models, Statistical; D008962:Models, Theoretical; D013269:Stochastic Processes; D013696:Temperature; D013997:Time Factors
D007477:Ions