alpha2-Adrenoreceptor antagonists.
A review of the literature relating to the therapeutic potential of alpha2-adrenoceptor antagonists published between 1990 and 2000 is presented. Although extensively studied since the early 1970s in a wide spectrum of therapeutic applications, the distinction of alpha2-adrenoceptor subtypes and some emerging evidence concerning new applications in neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases, obesity and schizophrenia, have refreshed an interest in this class of agents.
Centre de Recherche Pierre Fabre, Division de Chimie Medicinale III, 17 avenue Jean Moulin, F 81106, Castres, Cedex 06, France. patrice.mayer@pierre-fabre.com
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Imbert