Immunosurveillance by gammadelta T cells: focus on the murine system.
Physiologic immune responses are an integration of the activities of several lymphoid cell types that include qualitatively distinct T cell subsets. The contributions that specific T cell subsets make during infection, inflammation, and carcinogenesis is becoming increasingly clear from a variety of mouse models and, importantly, their backcrossing onto different genetic backgrounds. This review considers what we have learned in the mouse about the crucial roles played by gammadelta T cells. We consider how the cells' associations with specific tissues have revealed that T cell responses are regulated locally as well as systemically, and we discuss the implications of this for understanding and enhancing immune surveillance in the clinical setting.
Department of Dermatology, Yale University School of Medicine, New Haven, Conn., USA.
Michael
M
Girardi
Adrian C
AC
Hayday
D000818:Animals; D006801:Humans; D051379:Mice; D018448:Models, Immunological; D009374:Neoplasms, Experimental / Q000276:immunology; D009375:Neoplasms, Glandular and Epithelial / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000378:metabolism*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D016692:Receptors, Antigen, T-Cell, gamma-delta