Interferon research: a brief history.
Interferons are the antiviral early inflammatory proteins produced in the cells in response to the infectious agents. The characterization of the interferon genes, their expression, and their function was advanced with the development of novel techniques in molecular and cellular biology. Using genetically modified mice revealed the critical role of the interferons in innate and acquired immune response. The critical steps and discovery that lead to the understanding of the interferon system and its role in the antiviral immune response are summarized in this chapter.
The Sydney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, MD, USA.
Myriam S
MS
Kunzi
Paula M
PM
Pitha
D000818:Animals; D005786:Gene Expression Regulation; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007372:Interferons / Q000235:genetics / Q000266:history / Q000378:metabolism / Q000627:therapeutic use; D017471:Receptors, Interferon / Q000235:genetics / Q000378:metabolism; D012106:Research / Q000266:history*; D014777:Virus Diseases / Q000276:immunology / Q000628:therapy
D017471:Receptors, Interferon; D007372:Interferons