Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes.
We report the genome sequence of Theileria parva, an apicomplexan pathogen causing economic losses to smallholder farmers in Africa. The parasite chromosomes exhibit limited conservation of gene synteny with Plasmodium falciparum, and its plastid-like genome represents the first example where all apicoplast genes are encoded on one DNA strand. We tentatively identify proteins that facilitate parasite segregation during host cell cytokinesis and contribute to persistent infection of transformed host cells. Several biosynthetic pathways are incomplete or absent, suggesting substantial metabolic dependence on the host cell. One protein family that may generate parasite antigenic diversity is not telomere-associated.
Institute for Genomic Research (TIGR), 9712 Medical Center Drive, Rockville, MD 20850, USA. gardner@tigr.org
Malcolm J
MJ
Gardner
Richard
R
Bishop
Trushar
T
Shah
Etienne P
EP
de Villiers
Jane M
JM
Carlton
Neil
N
Hall
Qinghu
Q
Ren
Ian T
IT
Paulsen
Arnab
A
Pain
Matthew
M
Berriman
Robert J M
RJ
Wilson
Shigeharu
S
Sato
Stuart A
SA
Ralph
David J
DJ
Mann
Zikai
Z
Xiong
Shamira J
SJ
Shallom
Janice
J
Weidman
Lingxia
L
Jiang
Jeffery
J
Lynn
Bruce
B
Weaver
Azadeh
A
Shoaibi
Alexander R
AR
Domingo
Delia
D
Wasawo
Jonathan
J
Crabtree
Jennifer R
JR
Wortman
Brian
B
Haas
Samuel V
SV
Angiuoli
Todd H
TH
Creasy
Charles
C
Lu
Bernard
B
Suh
Joana C
JC
Silva
Teresa R
TR
Utterback
Tamara V
TV
Feldblyum
Mihaela
M
Pertea
Jonathan
J
Allen
William C
WC
Nierman
Evans L N
EL
Taracha
Steven L
SL
Salzberg
Owen R
OR
White
Henry A
HA
Fitzhugh
Subhash
S
Morzaria
J Craig
JC
Venter
Claire M
CM
Fraser
Vishvanath
V
Nene
D000465:Algorithms; D000818:Animals; D000953:Antigens, Protozoan / Q000235:genetics; D002417:Cattle; D049109:Cell Proliferation; D002875:Chromosomes / Q000235:genetics; D017124:Conserved Sequence; D004798:Enzymes / Q000235:genetics / Q000378:metabolism; D017125:Genes, Protozoan; D018503:Genome, Protozoan; D008214:Lymphocytes / Q000166:cytology / Q000469:parasitology*; D008928:Mitochondria / Q000378:metabolism; D008969:Molecular Sequence Data; D015388:Organelles / Q000235:genetics / Q000502:physiology; D010963:Plasmodium falciparum / Q000235:genetics; D017434:Protein Structure, Tertiary; D015800:Protozoan Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D017422:Sequence Analysis, DNA; D026801:Synteny; D016615:Telomere / Q000235:genetics; D016797:Theileria parva / Q000235:genetics* / Q000254:growth & development / Q000472:pathogenicity / Q000502:physiology
D000953:Antigens, Protozoan; D004798:Enzymes; D015800:Protozoan Proteins