Heart failure and shock complicating acute coronary syndromes.
Heart failure (HF) complicating acute coronary syndromes (ACS) is a heterogeneous clinical syndrome characterized by varying degrees of pulmonary congestion, and in its severest form, by profound organ hypoperfusion (cardiogenic shock). The occurrence of HF in patients with ACS has long been recognized as a strong predictor of increased morbidity and mortality. As such, there is increased interest in better understanding the epidemiology and management of this common clinical syndrome. This manuscript reviews recent insights from work in this area, including recent important trials evaluating the impact of renin-angiotensin system inhibition, early beta-blockade, and aggressive reperfusion strategies.
Department of Internal Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA. spencerf@ummhc.org
Frederick A
FA
Spencer
Theo
T
Meyer
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000789:Angina, Unstable / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004232:Diuretics / Q000627:therapeutic use; D006333:Heart Failure / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D009203:Myocardial Infarction / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D012770:Shock, Cardiogenic / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology*
D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D004232:Diuretics