Thioctic acid amides: convenient tethers for achieving low nonspecific protein binding to carbohydrates presented on gold surfaces.
The thioctic acid amides of 2'-aminoethyl alpha-d-mannopyranoside and 2'-aminoethyl alpha-1,3-d-mannopyranosyl (alpha-1,6-d-mannopyranosyl)-alpha-d-mannopyranoside presented on both planar and nanoparticle gold surfaces give higher specific and lower non-specific protein binding than the related 2'-thioethyl glycosides.
Centre for Carbohydrate Chemistry, School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, UK NR4 7TJ.
Rositsa
R
Karamanska
Balaram
B
Mukhopadhyay
David A
DA
Russell
Robert A
RA
Field
D000577:Amides / Q000737:chemistry*; D001665:Binding Sites; D002241:Carbohydrates / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D015394:Molecular Structure; D008970:Molecular Weight; D053758:Nanoparticles / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013499:Surface Properties; D008063:Thioctic Acid / Q000737:chemistry*; D013997:Time Factors
D000577:Amides; D002241:Carbohydrates; D011506:Proteins; D008063:Thioctic Acid; D006046:Gold