A cytogenetic study of Korean native goat bred in the nuclear power plant using the micronucleus assay.
Cytogenetic and hematological analysis was performed on the peripheral blood lymphocytes (PBLs) obtained from Korean native goats bred in two nuclear power plants (Wolsong and Uljin) and a control area. The frequencies of gamma-ray-induced micronuclei (MN) in the cytokinesis-blocked (CB) lymphocytes at several doses were measured in three Korean native goats. The measurements performed after irradiation showed dose-related increases in the MN frequency in each of the donors. The results were analyzed using a linear-quadratic model with a line of best fit of y=0.1019D+0.0045D2+0.0093 (y=number of MN/CB cells and D=irradiation dose in Gy). The MN rates in the goats from the Wolsong and Uljin nuclear power plant, and the control area were 9.60+/-2.88, 6.83+/-1.47 and 9.88+/-4.32 per 1,000 CB lymphocytes, respectively. The apparent difference is not statistically significant. The MN frequencies of PBLs from goats bred in three areas means that the values are within the background variation in this experiment. The MN frequencies and hematological values were similar regardless of whether the goats were bred in the nuclear power plant or the control area.
Kang
Chang Mo
CM
Korea Institute of Radiological & Medical Science, Seoul, Korea.
Lee
Hae June
HJ
Ji
Young Hoon
YH
Kim
Tae Hwan
TH
Ryu
Si Yun
SY
Kim
Se Ra
SR
Jo
Sung Kee
SK
Kim
Jong Choon
JC
Kim
Sung Ho
SH
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004781:Environmental Exposure / Q000009:adverse effects*; D005720:Gamma Rays / Q000009:adverse effects; D006041:Goats; D007723:Korea; D008214:Lymphocytes / Q000528:radiation effects*; D048629:Micronuclei, Chromosome-Defective / Q000528:radiation effects* / Q000662:veterinary*; D015162:Micronucleus Tests / Q000379:methods* / Q000662:veterinary*; D011210:Power Plants; D011829:Radiation Dosage