Restless legs syndrome.
Restless legs syndrome is a very common and still under-diagnosed neurologic condition that can cause severe morbidity. The pathology centers around central nervous system iron homeostatic dysregulation with subsequent alterations in dopaminergic functioning. Genetic studies will hopefully soon identify specific abnormalities. Treatment of restless legs syndrome with dopaminergic medications is highly effective, although augmentation may occur eventually and require dosing flexibility.
Ondo
William G
WG
Department of Neurology, Baylor College of Medicine, 6501 Fannin Street, Houston, TX 77030, USA. wondo@bcm.tmc.edu
D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism / Q000503:physiopathology*; D018491:Dopamine Agonists / Q000494:pharmacology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007501:Iron / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology; D012148:Restless Legs Syndrome / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy*; D013118:Spinal Cord Diseases / Q000150:complications; D014511:Uremia / Q000150:complications
D018491:Dopamine Agonists; D007501:Iron