Polymorphisms in the SLC2A2 (GLUT2) gene are associated with the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study.
Impaired insulin secretion is a fundamental defect in type 2 diabetes. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in the genes regulating insulin secretion (SLC2A2 [encoding GLUT2], GCK, TCF1 [encoding HNF-1alpha], HNF4A, GIP, and GLP1R) are associated with the conversion from impaired glucose tolerance (IGT) to type 2 diabetes in participants of the Finnish Diabetes Prevention Study. With the exception of SLC2A2, other genes were not associated with the risk of type 2 diabetes. All four SNPs of SLC2A2 predicted the conversion to diabetes, and rs5393 (AA genotype) increased the risk of type 2 diabetes in the entire study population by threefold (odds ratio 3.04, 95% CI 1.34-6.88, P = 0.008). The risk for type 2 diabetes in the AA genotype carriers was increased in the control group (5.56 [1.78-17.39], P = 0.003) but not in the intervention group. We conclude that the SNPs of SLC2A2 predict the conversion to diabetes in obese subjects with IGT.
Laukkanen
Olli
O
Department of Medicine, University of Kuopio, 70210 Kuopio, Finland.
Lindström
Jaana
J
Eriksson
Johan
J
Valle
Timo T
TT
Hämäläinen
Helena
H
Ilanne-Parikka
Pirjo
P
Keinänen-Kiukaanniemi
Sirkka
S
Tuomilehto
Jaakko
J
Uusitupa
Matti
M
Laakso
Markku
M
D000704:Analysis of Variance; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000517:prevention & control; D018450:Disease Progression; D005387:Finland; D005838:Genotype; D018149:Glucose Intolerance / Q000235:genetics*; D051273:Glucose Transporter Type 2; D006801:Humans; D009004:Monosaccharide Transport Proteins / Q000235:genetics*; D015999:Multivariate Analysis; D009765:Obesity / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
D051273:Glucose Transporter Type 2; D009004:Monosaccharide Transport Proteins