Treatment of eight dogs with nasal tumours with alternating doses of doxorubicin and carboplatin in conjunction with oral piroxicam.
OBJECTIVE
To determine the efficacy and toxicity of chemotherapy in the treatment of canine nasal tumours.


METHODS
Retrospective clinical study


METHODS
Eight dogs with histologically confirmed nasal tumours were staged by means of complete blood count, serum biochemical analysis, cytological analysis of fine needle aspirate of the regional lymph nodes, thoracic radiographs and computed tomography scan of the nasal cavity. All dogs were treated with alternating doses of doxorubicin, carboplatin and oral piroxicam. All dogs were monitored for side effects of chemotherapy and evaluated for response to treatment by computed tomography scan of the nasal cavity after the first four treatments.


RESULTS
Complete remission was achieved in four dogs, partial remission occurred in two dogs and two had stable disease on the basis of computed tomography evaluation. There was resolution of clinical signs after one to two doses of chemotherapy in all dogs.


CONCLUSIONS
This chemotherapy protocol was efficacious and well tolerated in this series of eight cases of canine nasal tumours.
Animal Cancer Care Pty Ltd, University of Queensland, Queensland 4072.
V
V
Langova
A J
AJ
Mutsaers
B
B
Phillips
R
R
Straw
D000230:Adenocarcinoma / Q000188:drug therapy / Q000662:veterinary; D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000662:veterinary; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy / Q000662:veterinary; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D004317:Doxorubicin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D008297:Male; D009669:Nose Neoplasms / Q000188:drug therapy / Q000662:veterinary*; D012516:Osteosarcoma / Q000188:drug therapy / Q000662:veterinary; D010894:Piroxicam / Q000008:administration & dosage; D011996:Records / Q000662:veterinary; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000662:veterinary
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; D004317:Doxorubicin; D016190:Carboplatin