The immunological synapse and Rho GTPases.
Rho GTPases are molecular switches controlling a broad range of cellular processes including lymphocyte activation. Not surprisingly, Rho GTPases are now recognized as pivotal regulators of antigen-specific T cell activation by APCs and immunological synapse formation. This review summarizes recent advances in our understanding of how Rho GTPase-dependent pathways control T lymphocyte motility, polarization and activation.
Deckert
M
M
INSERM Unit 576, Hôpital de l'Archet, BP3079, 06202 Nice, France. deckert@unice.fr
Moon
C
C
Le Bras
S
S
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D003599:Cytoskeleton / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology* / Q000502:physiology; D020741:rho GTP-Binding Proteins / Q000502:physiology*
D011948:Receptors, Antigen, T-Cell; D020741:rho GTP-Binding Proteins