Microalbuminuria and lower glomerular filtration rate at young adult age in subjects born very premature and after intrauterine growth retardation.
This prospective follow-up study of 422 19-yr-old subjects born very preterm in The Netherlands was performed to determine whether intrauterine growth retardation (IUGR) predisposes to abnormal GFR and microalbuminuria in adolescents. GFR (ml/min per 1.73 m2) was estimated using the Cockcroft-Gault equation, and albumin-creatinine ratio (mg/mmol) was calculated in a cohort of 19-yr-old subjects born very preterm (gestational age <32 wk) in 1983. Birth weights were adjusted for gestational age and expressed as standard deviation scores (sds) as a measure of IUGR. All subjects had normal renal function. Birth weight (sds) was associated negatively with serum creatinine concentration (micromol/L) (beta = -1.0 micromol/L, 95% confidence interval [CI]: -1.9 to -0.2), positively with GFR (beta = 3.0, 95% CI: 1.7 to 4.2), and negatively with the logarithm of albumin-creatinine ratio (beta = -0.05, 95% CI: -0.09 to -0.01) in young adults born very preterm. IUGR is associated with unfavorable renal functions at young adult age in subjects born very premature. These data suggest that intrauterine growth-retarded subjects born very premature have an increased risk to develop progressive renal failure in later life.
Department Pediatric Nephrology, Erasmus MC-Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Mandy G
MG
Keijzer-Veen
Marlies
M
Schrevel
Martijn J J
MJ
Finken
Friedo W
FW
Dekker
Jeroen
J
Nauta
Elysée T M
ET
Hille
Marijke
M
Frölich
Bert J
BJ
van der Heijden
D000328:Adult; D000419:Albuminuria / Q000196:embryology / Q000209:etiology* / Q000503:physiopathology; D001724:Birth Weight; D003404:Creatinine / Q000097:blood; D005260:Female; D005317:Fetal Growth Retardation / Q000503:physiopathology*; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007676:Kidney Failure, Chronic / Q000196:embryology / Q000209:etiology / Q000503:physiopathology; D008297:Male; D009426:Netherlands; D011446:Prospective Studies; D012307:Risk Factors
D003404:Creatinine