In vitro activities of levofloxacin and comparable agents against middle ear fluid, nasopharyngeal, and oropharyngeal pathogens obtained from Costa Rican children with recurrent otitis media or failing other antibiotic therapy.
This study analyzes the in vitro activities of levofloxacin and other commonly used antimicrobials against middle ear fluid, nasopharyngeal, and oropharyngeal pathogens obtained from children with otitis media at risk of having a resistant pathogen. Levofloxacin proved to be very active against these pathogens and had intermediate activity against Streptococcus pyogenes.
Soley
Carolina
C
Instituto de Atención Pediátrica, P.O. Box 607-1150, San José, Costa Rica.
Arguedas
Adriano
A
Porras
Wendy
W
Guevara
Silvia
S
Loaiza
Cecilia
C
Pérez
Alexandra
A
Rincón
Guillermo
G
Schultz
Malka
M
Arguedas
Jorge
J
Brilla
Roberto
R
D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002675:Child, Preschool; D003364:Costa Rica; D006193:Haemophilus influenzae / Q000187:drug effects; D006801:Humans; D007223:Infant; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D001936:Moraxella catarrhalis / Q000187:drug effects; D009305:Nasopharynx / Q000382:microbiology*; D015242:Ofloxacin / Q000494:pharmacology* / Q000627:therapeutic use; D009960:Oropharynx / Q000382:microbiology*; D010034:Otitis Media with Effusion / Q000188:drug therapy / Q000382:microbiology*; D012008:Recurrence; D013296:Streptococcus pneumoniae / Q000187:drug effects; D013297:Streptococcus pyogenes / Q000187:drug effects; D017211:Treatment Failure
D000900:Anti-Bacterial Agents; D064704:Levofloxacin; D015242:Ofloxacin