[Skin and soft tissue infections caused by Haemophilus influenzae type b over a 30 year period].
BACKGROUND
The skin and soft tissue infections caused by Haemophilus influenzae type b (Hib) are usually mild but can be potentially serious due to the high probability of bacteremia. Prompt instauration of empiric intravenous antibiotic therapy according to the localization and characteristics of the lesion is mandatory to prevent severe complications.


METHODS
Of 257 children admitted to the Children's Hospital of La Fe due to invasive Haemophilus influenzae type b disease (1973 to 2003), we reviewed 15 cases (5.8%) of skin and soft tissue infections, their outcome, complications and sequelae.


RESULTS
Ten children (66.7%) were aged < 2 years old. In eight patients (53.3%) there was a history of upper respiratory tract infection. Localization was in the head in 9 children (60%) and blood culture was positive in 10 patients (66.7%). Meningitis was a complication in 2 children (13.3%) and limited mobility of the hand was a sequel in one child (6.6%). After the universal establishment of the Hib vaccine in 1997, 3 new patients were admitted; 2 children with an infected thyroglossal cyst and another with cellulitis in the left leg. Of these children, one had received only the three primary doses of the vaccine but not the booster dose, and the remaining two were unvaccinated immigrant children.


CONCLUSIONS
Skin and soft tissue infections caused by Hib are potentially severe diseases with a risk of complications and sequelae. Due to the increase in unvaccinated immigrants and possible vaccine failures, universal immunization and epidemiological surveillance of carriers should be carried out to achieve total eradication.
Otero Reigada
M C
MC
Sección de Enfermedades Infecciosas Pediátricas, Hospital La Fe, Valencia, Spain. otero_car@gva.es
Piqueras Arenas
A I
AI
Ferrer Lorente
B
B
Pérez-Tamarit
D
D
Asensi Botet
F
F
Santos Durantez
M
M
D002648:Child; D002675:Child, Preschool; D006192:Haemophilus Infections / Q000453:epidemiology*; D019741:Haemophilus influenzae type b; D006801:Humans; D007223:Infant; D017192:Skin Diseases, Bacterial / Q000453:epidemiology* / Q000382:microbiology; D018461:Soft Tissue Infections / Q000453:epidemiology* / Q000382:microbiology; D013030:Spain / Q000453:epidemiology