Depression is associated with impairment of ADL, not motor function in Parkinson disease.
Depression was diagnosed in 15% of 100 consecutive patients with Parkinson disease (PD). Depression was associated with lower cognition, history of depression, and a higher Unified Parkinson's Disease Rating Scale score. The latter was due to differences in the activities of daily living (ADL) subscale (17 +/- 7 vs 12 +/- 6; p = 0.004) rather than the motor subscale (30 +/- 13 vs 26 +/- 13; p = 0.27). These results suggest that ADL impairment may in part be due to depression. Patients with PD with poor function should be closely evaluated for depression.
Department of Psychiatric Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA. sh4s@virginia.edu
Suzanne
S
Holroyd
Lillian J
LJ
Currie
G Frederick
GF
Wooten
D000203:Activities of Daily Living / Q000523:psychology*; D000368:Aged; D003072:Cognition Disorders / Q000503:physiopathology / Q000523:psychology; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003866:Depressive Disorder / Q000453:epidemiology / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000453:epidemiology / Q000503:physiopathology / Q000523:psychology*; D015995:Prevalence