Positive association of AKT1 haplotype to Japanese methamphetamine use disorder.
Recent evidence suggests that the AKT1-GSK3beta signalling cascade partially mediates dopamine-dependent behaviours. In relation to the pathophysiology of schizophrenia or methamphetamine (Meth) use disorder, AKT1 is a good candidate gene for such conditions. For schizophrenia, positive associations of SNPs and AKT1 haplotypes were reported in US and Japanese samples. To evaluate the association between AKT1 and Meth-use disorder, we conducted a case-control study of Japanese samples (182 patients and 437 controls). A positive association between a SNP and haplotypes was found, and the 'signal' SNP was the same SNP found to be associated with US schizophrenia, but not with Japanese schizophrenia. Our results indicate that AKT1 may play a possible role in the development of Meth-use disorder. Further investigation of these associations, together with evidence from previous animal studies, may open the way to elucidation of the pathophysiology of this condition.
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Masashi
M
Ikeda
Nakao
N
Iwata
Tatsuyo
T
Suzuki
Tsuyoshi
T
Kitajima
Yoshio
Y
Yamanouchi
Yoko
Y
Kinoshiya
Yoshimoto
Y
Sekine
Masaomi
M
Iyo
Mutsuo
M
Harano
Tokutaro
T
Komiyama
Mitsuhiko
M
Yamada
Ichiro
I
Sora
Hiroshi
H
Ujike
Toshiya
T
Inada
Norio
N
Ozaki
D000328:Adult; D019969:Amphetamine-Related Disorders / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D007564:Japan; D008297:Male; D008694:Methamphetamine; D020641:Polymorphism, Single Nucleotide; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics*
D008694:Methamphetamine; C494918:AKT1 protein, human; D051057:Proto-Oncogene Proteins c-akt