Induction of telithromycin resistance by erythromycin in isolates of macrolide-resistant Staphylococcus spp.
Staphylococcal isolates were examined for possible macrolide-inducible resistance to telithromycin. All macrolide-resistant isolates demonstrated telithromycin D-shaped zones. This result did not discriminate between resistance due to an efflux mechanism (msrA) or a ribosomal target modification (ermA or ermC). Inducible telithromycin resistance in staphylococci does not appear to be analogous to inducible clindamycin resistance.
Infectious Disease Service, Department of Medicine, Brooke Army Medical Center, Ft. Sam Houston, Texas 78234, USA. kepler.davis@amedd.army.mil
Kepler A
KA
Davis
Sharon A
SA
Crawford
Kristin R
KR
Fiebelkorn
James H
JH
Jorgensen
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D003030:Coagulase / Q000378:metabolism; D024901:Drug Resistance, Multiple, Bacterial; D004917:Erythromycin / Q000494:pharmacology; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D048628:Ketolides / Q000494:pharmacology*; D018942:Macrolides / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013210:Staphylococcus / Q000145:classification / Q000187:drug effects* / Q000201:enzymology; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D003030:Coagulase; D048628:Ketolides; D018942:Macrolides; D004917:Erythromycin; C106791:telithromycin