Novel karyotypic changes detected by comparative genomic hybridization in a case of congenital cervical immature teratoma.
BACKGROUND
Cervical immature teratoma is a rare congenital tumor, and very few cases have been studied cytogenetically.


METHODS
In this article, we describe a case of this tumor type and present the findings of the karyotype of the lesion, which was performed with the bacterial artificial chromosome arrays using the comparative genomic hybridization method. The chromosomal abnormalities that we found included an amplification on 1p21.1, a 9p22 deletion, and a 1-copy gain of 17q21.33.


CONCLUSIONS
None of the identified chromosomal aberrations have been previously associated with congenital extragonadal teratomas. Important genes that lie in these DNA regions may be implicated in the pathogenesis of congenital teratomas.
Miliaras
Dimosthenis
D
Laboratory of Histology, Embryology & Anthropology, Medical Faculty, Aristotle University of Thessaloniki, Greece. dmiliara@med.auth.gr
Grimbizis
Grigoris
G
Conroy
Jeffrey
J
Psarra
Natasha
N
Miliaras
Spyros
S
Nowak
Norma
N
Bontis
John
J
D000328:Adult; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000235:genetics*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology; D013724:Teratoma / Q000151:congenital / Q000235:genetics* / Q000473:pathology