That which does not kill you makes you stronger: a molecular mechanism for preconditioning.
Preconditioning by sublethal stress can protect a cell from subsequent injury and apoptosis through a mechanism that has been unclear. Many such stresses stimulate the formation of stress granules: transient cytoplasmic foci that contain heat shock protein as well as translationally stalled mRNA and various mRNA-binding proteins. Recent research suggests that sequestration in stress granules of TRAF2, an adaptor protein that is required for tumor necrosis factor receptor 1 signaling, may underlie preconditioning by sublethal stresses.
Cellular Injury and Adaptation Laboratory, Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jonathan E
JE
McDunn
J Perren
JP
Cobb
D000818:Animals; D003594:Cytoplasmic Granules / Q000502:physiology; D015852:Eukaryotic Initiation Factor-2 / Q000502:physiology; D039603:Eukaryotic Initiation Factor-4G / Q000502:physiology; D005544:Forecasting; D006358:Hot Temperature; D006801:Humans; D019194:Ischemic Preconditioning; D018551:Solanum lycopersicum; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D010940:Plant Proteins / Q000502:physiology; D011487:Protein Conformation; D025941:Protein Interaction Mapping; D017434:Protein Structure, Tertiary; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology; D013312:Stress, Physiological / Q000503:physiopathology*; D047992:TNF Receptor-Associated Factor 2 / Q000737:chemistry / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology; D019892:eIF-2 Kinase / Q000502:physiology
D015852:Eukaryotic Initiation Factor-2; D039603:Eukaryotic Initiation Factor-4G; D010940:Plant Proteins; D018124:Receptors, Tumor Necrosis Factor; D047992:TNF Receptor-Associated Factor 2; D014409:Tumor Necrosis Factor-alpha; D019892:eIF-2 Kinase