Prevention of chromate induced oxidative stress by alpha-lipoic acid.
The parenteral administration of alpha-lipoic acid (LA) protected against chromate induced oxidative stress in mouse liver. A shift in Cr induced pro-oxidant state to antioxidant-state by LA was noteworthy. The degree of protection was significant and similar in different LA administration regimens (prior-, co- and post- parenteral Cr exposure) explored. An improved status of the tissue antioxidants by LA appeared to be the mechanism of mitigation. The results are of chemopreventive value and suggest a possible alternative to ascorbic acid for abrogation of Cr toxicity.
Environmental Carcinogenesis Section, Industrial Toxicology Research Center, Post Box 80, MG Marg, Lucknow 226001, UP, India.
Roli
R
Budhwar
Sushil
S
Kumar
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002244:Carbon / Q000737:chemistry; D002374:Catalase / Q000378:metabolism; D002840:Chromates / Q000494:pharmacology*; D002857:Chromium / Q000737:chemistry / Q000506:poisoning; D005978:Glutathione / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D016877:Oxidants / Q000378:metabolism; D018384:Oxidative Stress; D010100:Oxygen / Q000378:metabolism; D011192:Potassium Dichromate / Q000737:chemistry; D013482:Superoxide Dismutase / Q000378:metabolism; D008063:Thioctic Acid / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D013997:Time Factors
D000975:Antioxidants; D002840:Chromates; D016877:Oxidants; D002857:Chromium; D008063:Thioctic Acid; D002244:Carbon; D002374:Catalase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005978:Glutathione; D010100:Oxygen; D011192:Potassium Dichromate