Australian bat lyssavirus: a recently discovered new rhabdovirus.
Australian bat lyssavirus (ABLV), first identified in 1996, has been associated with two human fatalities. ABLV is genetically and serologically distinct from, but is closely related to, classical rabies. It has a bullet-shaped morphology by electron microscopy. There are two strains of ABLV known: one circulates in frugivorous bats, sub-order Megachiroptera, and the other circulates in the smaller, mainly insectivorous bats, sub-order Microchiroptera. Each strain has been associated with one human fatality. Surveillance indicates infected bats are widespread at a low frequency on the Australian mainland. It is unclear how long ABLV has been present in Australia, although molecular clock studies suggest the two strains separated 950 or 1,700 years ago based on synonymous or non-synonymous nucleotide changes, respectively. Recent serological surveys suggest a closely related virus may exist in the Philippines. Due to demonstrated cross-protection in mice, rabies vaccine is used to prevent infection. Rabies post-exposure prophylaxis (PEP) protocols have been adopted for when a human is scratched or bitten by a suspect bat. A long-term commitment to public health programs that test bats that have been involved in scratch or bite incidents, followed by PEP if appropriate, will be necessary to minimise further human infection.
Public Health Virology Laboratory, Queensland Health Scientific Services, 39 Kessels Rd, 4108 Coopers Plains, Queensland, Australia. David.Warrilow@qimr.edu.au
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D000818:Animals; D002685:Chiroptera / Q000821:virology*; D019143:Evolution, Molecular; D016679:Genome, Viral; D006801:Humans; D018114:Lyssavirus / Q000145:classification* / Q000302:isolation & purification* / Q000502:physiology / Q000648:ultrastructure; D017720:Molecular Epidemiology; D011159:Population Surveillance; D011634:Public Health; D012367:RNA, Viral / Q000235:genetics; D011819:Rabies Vaccines / Q000276:immunology; D018353:Rhabdoviridae Infections / Q000453:epidemiology / Q000473:pathology / Q000517:prevention & control / Q000821:virology*
D012367:RNA, Viral; D011819:Rabies Vaccines