Serum glucose concentration and ACP1 genotype in healthy adult subjects.
Acid phosphatase locus 1 (ACP 1 ) or cytosolic low molecular weight protein tyrosine phosphatase is a polymorphic enzyme that can hydrolyze phosphotyrosine-containing peptides of the human insulin receptor and of band 3 protein. High-activity ACP 1 may favor an increase in serum glucose concentration through a depression of insulin action and through inactivation of aldolase, phosphofructokinase, and glyceraldehyde-3-phosphate dehydrogenase induced by dephosphorylation of band 3 protein. In diabetic subjects, we have previously reported lower serum glucose concentration in subjects with low-activity ACP 1 A and AB phenotypes. We have now studied the relationship between serum glucose concentration and ACP 1 genotype in a sample of 137 healthy adult workers of our university. In males, serum glucose concentration is significantly higher in medium-high- than in low-activity ACP 1 genotypes. With advancing age in males, there is a progressive increase in glycemic differential between medium-high- and low-activity ACP 1 genotypes. The data suggest that normal variability of ACP 1 genotype influences serum glucose concentration in normal individuals. Such influence depends on sex and in males becomes more marked with advancing age.
Iannaccone
Umberto
U
Division of Occupational Health Medicine, Department of Biopathology and Imaging Diagnostics, School of Medicine, University of Rome Tor Vergata, 00123 Rome Italy.
Bergamaschi
Antonio
A
Magrini
A
A
Marino
Giuseppe
G
Bottini
Nunzio
N
Lucarelli
Paola
P
Bottini
Egidio
E
Gloria-Bottini
Fulvia
F
D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D005260:Female; D005634:Fructose-Bisphosphate Aldolase / Q000037:antagonists & inhibitors; D005838:Genotype; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000037:antagonists & inhibitors; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D008297:Male; D010732:Phosphofructokinase-1 / Q000037:antagonists & inhibitors; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D012016:Reference Values
D001786:Blood Glucose; D007527:Isoenzymes; D011518:Proto-Oncogene Proteins; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D010732:Phosphofructokinase-1; C068652:1-phosphofructokinase; C490429:ACP1 protein, human; D017027:Protein Tyrosine Phosphatases; D005634:Fructose-Bisphosphate Aldolase