New insights into the pathophysiology of gastrointestinal graft-versus-host disease using capsule endoscopy.
We investigated gastrointestinal graft-versus-host-disease using capsule endoscopy in patients with abdominal pain and/or diarrhea. We found severe pathology involving most of the gut including loss of villi, ulcerations, narrowing, bleeding and fistula formation. In 2 patients, capsule endoscopy alone established the diagnosis of graft-versus-host-disease. Some ulcerations were associated with cytomegalovirus infection.
Shapira
Michael
M
Adler
Samuel N
SN
Jacob
Harold
H
Resnick
Igor B
IB
Slavin
Shimon
S
Or
Reuven
R
D003586:Cytomegalovirus Infections / Q000209:etiology; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis; D041981:Gastrointestinal Tract / Q000473:pathology / Q000503:physiopathology*; D005772:Gastrointestinal Transit; D006086:Graft vs Host Disease / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation; D007410:Intestinal Diseases; D007412:Intestinal Fistula / Q000473:pathology