Region specific distribution of levomepromazine in the human brain.
OBJECTIVE
The aim of this study was to examine concentrations of levomepromazine and its metabolite desmethyl-levomepromazine in different regions of human brain and in relationship to drug-free time.


METHODS
Drug concentrations were measured in up to 43 regions of 5 postmortem human brains of patients previously treated with levomepromazine. To enable statistical comparison across brain regions several smaller brain areas were put together to form larger brain areas (cortex cerebri, limbic system, cerebellum, basal ganglia, thalamus). Mean values of drug concentrations in these larger brain areas were used in a repeated measurement ANOVA to analyze for region specific distribution. The elimination half-life in brain tissue was estimated with a NONMEM population kinetic analysis using the mean value of all brain regions of an individual case.


RESULTS
Levomepromazine and desmethyl-levomepromazine appear to accumulate in human brain tissue relative to blood. Mean concentrations differed largely between individual brains, in part due to differences in dose of drug, duration of treatment and drug-free time before death. There was an apparent region-specific difference in levomepromazine concentrations with highest values in the basal ganglia (mean 316 ng/g) and lowest values in the cortex cerebri (mean 209 ng/g). The elimination half-life from brain tissue is longer than from blood and was calculated to be about one week. Similar results were obtained with desmethyl-levomepromazine.


CONCLUSIONS
Levomepromazine shows a region-specific distribution in the human brain with highest values in the basal ganglia. This might be the consequence of low expression of the metabolic enzyme Cyp2D6 in the basal ganglia. If this finding is true also for other neuroleptic drugs it might increase our understanding of preferential toxicity of neuroleptic drugs against basal ganglia structures and higher volumes of basal ganglia of neuroleptic-treated patients. Furthermore, patients exposed to levomepromazine cannot be considered to be free of residual effects of the drug for a number of weeks after withdrawal.
Department of Psychiatry, University of Erlangen, Germany. Johannes.Kornhuber@psych.imed.uni-erlangen.de
J
J
Kornhuber
H
H
Weigmann
J
J
Röhrich
J
J
Wiltfang
S
S
Bleich
I
I
Meineke
R
R
Zöchling
S
S
Härtter
P
P
Riederer
C
C
Hiemke
D000368:Aged; D000369:Aged, 80 and over; D014150:Antipsychotic Agents / Q000378:metabolism / Q000493:pharmacokinetics*; D001479:Basal Ganglia / Q000187:drug effects / Q000378:metabolism; D001921:Brain / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism; D019389:Cytochrome P-450 CYP2D6 / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects / Q000502:physiology; D008728:Methotrimeprazine / Q000378:metabolism / Q000493:pharmacokinetics*; D015394:Molecular Structure
D014150:Antipsychotic Agents; D008728:Methotrimeprazine; D019389:Cytochrome P-450 CYP2D6