Salvinicins A and B, new neoclerodane diterpenes from Salvia divinorum.
[reaction: see text] Two new neoclerodane diterpenes, salvinicins A (4) and B (5), were isolated from the dried leaves of Salvia divinorum. The structures of these compounds were elucidated by spectroscopic techniques, including (1)H and (13)C NMR, NOESY, HMQC, and HMBC. The absolute stereochemistry of these compounds was assigned on the basis of single-crystal X-ray crystallographic analysis of salvinicin A (4) and a 3,4-dichlorobenzoate derivative of salvinorin B.
Division of Medicinal & Natural Products Chemistry, The University of Iowa, Iowa City, 52242, USA.
Wayne W
WW
Harding
Kevin
K
Tidgewell
Matthew
M
Schmidt
Kushal
K
Shah
Christina M
CM
Dersch
John
J
Snyder
Damon
D
Parrish
Jeffrey R
JR
Deschamps
Richard B
RB
Rothman
Thomas E
TE
Prisinzano
D018360:Crystallography, X-Ray; D004224:Diterpenes; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D009292:Narcotic Antagonists; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D027544:Salvia / Q000737:chemistry*
D004224:Diterpenes; D045785:Diterpenes, Clerodane; D009292:Narcotic Antagonists; C468586:neoclerodane; C509586:salvinicin A; C509587:salvinicin B