GenePath: from mutations to genetic networks and back.
GenePath is a web-based application for the analysis of mutant-based experiments and synthesis of genetic networks. Here, we introduce GenePath and describe a number of new approaches, including conflict resolution, handling cyclic pathways, confidence level assignment, what-if analysis and new experiment proposal. We illustrate the key concepts using data from a study of adhesion genes in Dictyostelium discoideum and show that GenePath discovered genetic interactions that were ignored in the original publication. GenePath is available at http://www.genepath.org/genepath2.
Juvan
Peter
P
Faculty of Computer and Information Science, University of Ljubljana, Ljubljana, Slovenia.
Demsar
Janez
J
Shaulsky
Gad
G
Zupan
Blaz
B
D000818:Animals; D019295:Computational Biology; D004023:Dictyostelium / Q000235:genetics; D004843:Epistasis, Genetic; D005796:Genes; D023281:Genomics; D020407:Internet; D008957:Models, Genetic; D009154:Mutation; D012984:Software; D014584:User-Computer Interface