Cooperative uptake of microcin E492 by receptors FepA, Fiu, and Cir and inhibition by the siderophore enterochelin and its dimeric and trimeric hydrolysis products.
Microcin E492 uptake by FepA, Fiu, and Cir is cooperative, with FepA being the main receptor. No TonB-mediated interaction with the ferric catecholate receptors is needed for microcin to exert action at the cytoplasmic membrane. Microcin E492 uptake by the receptors is inhibited by the dimer and trimer of dihydroxybenzoylserine.
Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile.
Erwin
E
Strahsburger
Marcelo
M
Baeza
Octavio
O
Monasterio
Rosalba
R
Lagos
D000900:Anti-Bacterial Agents / Q000378:metabolism; D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism*; D001430:Bacteriocins / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism; D019281:Dimerization; D004758:Enterobactin / Q000378:metabolism*; D006868:Hydrolysis; D010455:Peptides; D011956:Receptors, Cell Surface / Q000378:metabolism*; D017262:Siderophores / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D001425:Bacterial Outer Membrane Proteins; D001430:Bacteriocins; D002352:Carrier Proteins; D010455:Peptides; D011956:Receptors, Cell Surface; D017262:Siderophores; C029489:enterobactin receptor; C035902:siderophore receptors; C020411:microcin; D004758:Enterobactin