Design and synthesis of protein superfamily-targeted chemical libraries for lead identification and optimization.
This review chronicles original literature dating back to 1992 outlining the applications of parallel synthesis and combinatorial chemistry to the synthesis of compound libraries focused towards specific superfamilies of molecular targets. Target families that have received significant literature coverage include kinases, proteases, nuclear hormone receptors and cell surface receptors, notably GPCRs.
Shuttleworth
Stephen J
SJ
Department of Chemistry, Tularik Inc., 1120 Veterans Boulevard, South San Francisco, CA 94404, USA. Stephen.Shuttleworth@piramed.com
Connors
Richard V
RV
Fu
Jiasheng
J
Liu
Jinqian
J
Lizarzaburu
Mike E
ME
Qiu
Wei
W
Sharma
Rajiv
R
Wãnska
Malgorzata
M
Zhang
Alex J
AJ
D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D011494:Protein Kinases / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000037:antagonists & inhibitors / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors / Q000378:metabolism*
D004791:Enzyme Inhibitors; D018160:Receptors, Cytoplasmic and Nuclear; D043562:Receptors, G-Protein-Coupled; D011494:Protein Kinases