Soybean oil in total parenteral nutrition maintains albumin and antioxidant enzyme mRNA levels.
Changes in albumin and antioxidant enzyme mRNA expression in infant rat liver following administration of total parenteral nutrition (TPN) with/without soybean oil emulsion were studied. Infant rats were divided into three groups: group 1=oral diet, group 2=TPN without fat, and group 3=TPN with 20% of calories from soybean oil emulsion. The period of TPN administration was 4 d. Serum aspartate aminotransferase and alanine aminotransferase levels were higher in group 2 than in the other groups, with similar levels seen in the other groups. Albumin, Cu, Zn-superoxide dismutase, and glutaredoxin 1 mRNA expression levels were lower in group 2 than in the other groups, with similar levels seen in the other groups. Catalase mRNA expression was higher in group 1 than in the other groups, with the lowest level seen in group 2. Soybean oil emulsion should be included in TPN regimens to prevent down-regulation of albumin and antioxidant enzyme mRNA expression.
Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc., Tokushima, Japan. nisimums@otsukakj.co.jp
Masuhiro
M
Nishimura
Aiko
A
Yamauchi
Mari
M
Yamaguchi
Nobuhiko
N
Ueda
Shinsaku
S
Naito
D000418:Albumins / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D017931:DNA Primers; D054477:Glutaredoxins; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010088:Oxidoreductases / Q000235:genetics*; D010289:Parenteral Nutrition, Total; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013024:Soybean Oil / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000235:genetics*
D000418:Albumins; D017931:DNA Primers; C516007:Glrx protein, rat; C516010:Glrx2 protein, rat; D054477:Glutaredoxins; D012333:RNA, Messenger; D013024:Soybean Oil; D010088:Oxidoreductases; D013482:Superoxide Dismutase