Evidence of recombination between divergent hepatitis E viruses.
Phylogenetic and recombination analysis was performed on 32 complete hepatitis E virus (HEV) genomes from infected humans and pigs. For the first time, evidence for recombination between divergent HEV strains was obtained, with at least two strains being found to have discordant phylogenetic relationships consistent with the occurrence of intragenotype recombination. This finding confirms that humans can be dually infected with divergent HEV strains and has implications for the emergence and evolution of new HEV epidemics.
Etat Major des Armées, Maîtrise des Armements, Cellule d'analyse des risques biologiques it chimiques, Paris, France.
Hélène
H
van Cuyck
Jun
J
Fan
David L
DL
Robertson
Pierre
P
Roques
D016752:Hepatitis E virus / Q000145:classification / Q000235:genetics*; D010802:Phylogeny; D011995:Recombination, Genetic