Exposure to high fluoride concentration in drinking water will affect spermatogenesis and steroidogenesis in male albino rats.
Sodium fluoride (NaF) administered orally to adult male rats at a dose level of 4.5 ppm and 9.0 ppm for 75 days caused significant decrease in the body weight, brain index and testicular index. A significant decrease in sperm count, sperm motility, sperm viability and sperm function (HOS positive) with increased sperm abnormalities was also observed in NaF-exposed male rats. The activity levels of testicular steroidogenic marker enzymes 3beta-hydroxysteroid dehydrogenase (3beta-HSD) and 17beta-hydroxysteroid dehydrogenase (17beta-HSD) were significantly decreased in NaF-treated rats indicating decreased steroidogenesis and in turn spermatogenesis in rats exposed to NaF.
Department of Biotechnology, Sri Venkateswara University, Tirupati - 517 502, India.
T
T
Pushpalatha
M
M
Srinivas
P
P
Sreenivasula Reddy
D015067:17-Hydroxysteroid Dehydrogenases / Q000378:metabolism; D000818:Animals; D015415:Biomarkers / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D004326:Drinking; D005459:Fluorides / Q000008:administration & dosage* / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013081:Sperm Motility / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D013094:Spermatozoa / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D013256:Steroids / Q000096:biosynthesis*; D014867:Water / Q000008:administration & dosage* / Q000737:chemistry*
D015415:Biomarkers; D013256:Steroids; D014867:Water; D015067:17-Hydroxysteroid Dehydrogenases; C044256:3 (or 17)-beta-hydroxysteroid dehydrogenase; D005459:Fluorides