Evaluation of 1H-magnetic resonance spectroscopy of breast cancer pre- and postgadolinium administration.
OBJECTIVE
We sought to evaluate spectroscopic measurements in breast cancer and compare variability in choline peak parameters related to contrast administration versus that inherent to repeated measurements.


METHODS
Single-voxel, proton spectroscopy measurements were obtained before and after the administration of gadolinium on 15 patients with > or = 1-cm breast cancers. The protocol was repeated on a separate day in 7 patients.


RESULTS
Postcontrast spectra demonstrated a significant increase in choline peak linewidth (day 1: 15% +/- 21%, P = 0.03; day 2: 19% +/- 12%, P = 0.001) and decrease in choline peak area (day 1: 11% +/- 9% (P < 0.001); day 2: 18% +/- 21% (P = 0.03). A variance-components analysis indicated that day-to-day variation in linewidth accounted for 0.0% of the total variation in width measurements and was not significant (P = 0.85). Day-to-day variation in area was also not significant (0.0%, P = 0.95).


CONCLUSIONS
Contrast administration caused significant increases in choline peak linewidth and decreases in choline peak area in spectroscopic measurements of breast cancer.
Joe
Bonnie N
BN
Abdominal Imaging, Department of Radiology, University of California, San Francisco 94143-0628, USA. joe@radiology.ucsf.edu
Chen
Victoria Y
VY
Salibi
Nouha
N
Fuangtharntip
Pornpim
P
Hildebolt
Charles F
CF
Bae
Kyongtae T
KT
D001943:Breast Neoplasms / Q000175:diagnosis*; D002794:Choline / Q000032:analysis; D003287:Contrast Media / Q000494:pharmacology*; D005260:Female; D005682:Gadolinium / Q000008:administration & dosage; D006801:Humans; D007089:Image Enhancement; D009682:Magnetic Resonance Spectroscopy; D019047:Phantoms, Imaging; D013997:Time Factors
D003287:Contrast Media; D005682:Gadolinium; D002794:Choline