Grayanane diterpenoids from the leaves of Craiobiodendron yunnanense.
Ten new grayanane diterpenoids, craiobiotoxins I-VIII (1-8) and craiobiosides A (9) and B (10), and five known grayanane diterpenoids, grayanotoxin XVIII, lyoniol A, lyoniol B, pieristoxin H, and grayanoside B were isolated from the leaves of Craiobiodendron yunnanense (Ericaceae). The structures of 1-10 were elucidated by spectroscopic methods including various 2D NMR and X-ray crystal diffraction experiments. In biological testing of our isolates, craiobiotoxin III (3) and lyoniol B showed moderate antifeedant activity.
Zhang
Hua-Ping
HP
Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, PR China.
Wang
Li-Quan
LQ
Qin
Guo-Wei
GW
D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D029791:Ericaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D018515:Plant Leaves / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction
D004224:Diterpenes