[The comparison of optimized pharmacodynamic dosing strategy for meropenem using Monte Carlo simulation].
Monte Carlo simulation was enmloyed to determine pharmacodynamic target attainment rates for several meropenem dosage regimens against E. coli and P. aeruginosa populations. Percent Time above MIC (% T > MIC) exposures for several meropenem dosage regimens were simulated for 10,000 subjects. Variability in pharmacokinetic parameters and MIC distributions were derived from studies in healthy volunteers and the injection antibiotics include of Meropenem susceptibility test surveillance program. The probabilities of attaining bacteriostatic responses (30% T > MIC) and bactericidal responses (50% T > MIC) exposures were high for all dosage regimens against populations of E. coli. Against P. aeruginosa, the 1000 g 3.0 infusion q8 dosage regimen provided the hightest target attainment rates. Further study of these dosage recommendations in clinical trials is suggested.
Division of Anaerobe Research, Life Science Research Center, Gifu University.
Hiroshige
H
Mikamo
Kyoichi
K
Totsuka
D000328:Adult; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D000077731:Meropenem; D009010:Monte Carlo Method; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013845:Thienamycins / Q000008:administration & dosage* / Q000493:pharmacokinetics
D013845:Thienamycins; D000077731:Meropenem