Biotin-dependent regulation of gene expression in human cells.
The role of biotin as cofactor of carboxylases and its importance in metabolic homeostasis are well known. In recent years, different researchers have suggested the participation of biotin as a regulator molecule in the control of gene expression. Biotin-dependent gene expression requires of the transformation of biotin into biotinyl-5'-AMP by holocarboxylase synthetase and the activation of soluble guanylate cyclase and a cGMP-dependent protein kinase. The regulatory role of biotin is responsible for the correct expression of enzymes involved in biotin utilization in human cells. We propose that this mechanism protects the brain from biotin deficiency.
Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico, DF 04510, Mexico. leon@biomedicas.unam.mx
Alfonso
A
León-Del-Río
D001710:Biotin / Q000172:deficiency / Q000378:metabolism*; D028921:Biotinidase Deficiency / Q000378:metabolism; D019731:Carbon-Nitrogen Ligases / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D028922:Holocarboxylase Synthetase Deficiency / Q000378:metabolism; D006801:Humans; D027981:Symporters / Q000235:genetics / Q000378:metabolism
D027981:Symporters; C119981:biotin transporter; D001710:Biotin; D019731:Carbon-Nitrogen Ligases; C023312:holocarboxylase synthetases