Novel lentiviral vectors for human gene therapy.
This review summarises an emerging viral vector system for use in human gene therapy - lentiviral vectors. Lentiviral vectors have several advantages over existing viral vectors. They can stably express transgenes in non-dividing cells in vivo without provoking a significant immune response. They can be produced to a high titre and can be pseudotyped with heterologous envelope proteins to confer broad tropism. Although not without safety concerns, the properties of lentiviral vectors makes them an attractive choice for human gene therapy.
Dropulic
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Oncology Center, The Johns Hopkins University, Baltimore, Maryland, USA. dropulic@welchlink.welch.jhu.edu