Allocolchicinoid synthesis via direct arylation.
[reaction: see text] A formal enantioselective synthesis of allocolchicine and a synthesis of a C-ring analogue have been achieved by employing an intramolecular direct arylation of an aryl chloride to form the biaryl carbon-carbon bond and the seven-membered ring.
Leblanc
Mélissa
M
Center for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, Ontario, Canada.
Fagnou
Keith
K
D002384:Catalysis; D003078:Colchicine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D003500:Cyclization; D006846:Hydrocarbons, Halogenated / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D013237:Stereoisomerism
D006846:Hydrocarbons, Halogenated; D010165:Palladium; C032782:allocolchicine; D003078:Colchicine