IMRT to escalate the dose to the prostate while treating the pelvic nodes.
OBJECTIVE
To assess and quantify the benefit of introducing intensity-modulated radiotherapy (IMRT) over conventional approaches to cover the pelvic nodes while escalating the dose to the prostate gland.


METHODS
The pelvic lymphatics were planned to receive 50 Gy at 2 Gy per fraction by four-field box (4FB) technique and standard field blocks drawn on digitally reconstructed radiographs (DRR), 4FB with field blocks according to the position of pelvic nodes as contoured on serial planning CT slices, or IMRT. The lateral fields included three different variations of field blocks to assess the role of various degrees of rectal shielding. The boost consisted in 26 Gy in 13 fractions delivered via six-field three-dimensional conformal radiotherapy (3DCRT) or IMRT. By the combination of a pelvic treatment and boost, several plans were obtained for each patient, all normalized to be isoeffective with regard to prostate-planning target volume (PTV-P) coverage. Plans were compared with respect to dose-volume histogram (DVH) of pelvic nodes/seminal vesicles-PTV (PTV-PN/SV), rectum, bladder and intestinal cavity. Reported are the results obtained in eight patients.


RESULTS
Pelvic IMRT with a conformal boost provided superior sparing of both bladder and rectum over any of the 4FB plans with the same boost. For the rectum the advantage was around 10% at V70 and even larger for lower doses. Coverage of the pelvic nodes was adequate with initial IMRT with about 98% of the volume receiving 100% of the prescribed dose. An IMRT boost provided a gain in rectal sparing as compared to a conformal boost. However, the benefit was always greater with pelvic IMRT followed by a conformal boost as compared to 4FB with IMRT boost. Finally, the effect of utilizing an IMRT boost with initial pelvic IMRT was greater for the bladder than for the rectum (at V70, about 9% and 3% for the bladder and rectum, respectively).


CONCLUSIONS
IMRT to pelvic nodes with a conformal boost allows dose escalation to the prostate while respecting current dose objectives in the majority of patients and it is dosimetrically superior to 4FB. An IMRT boost should be considered for patients who fail to meet bladder dose objectives.
Department of Radiation Oncology, University of Texas Medical Branch, Galveston, TX, USA. mlcavey@utmb.edu
Matthew L
ML
Cavey
John E
JE
Bayouth
Martin
M
Colman
Eugene J
EJ
Endres
Giuseppe
G
Sanguineti
D003198:Computer Simulation; D006801:Humans; D021621:Imaging, Three-Dimensional; D008197:Lymph Node Excision / Q000379:methods; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D008297:Male; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy*; D011859:Radiography; D011879:Radiotherapy Dosage; D011881:Radiotherapy, Computer-Assisted; D012007:Rectum / Q000528:radiation effects; D015203:Reproducibility of Results; D013813:Therapy, Computer-Assisted; D001743:Urinary Bladder / Q000528:radiation effects