Identification of a new allele in a Sicilian individual: HLA-DPB1*0302.
We report here the identification and characterization of a novel human leucocyte antigen (HLA)-DPB1 allele that was subsequently named HLA-DPB1*0302 by the WHO Nomenclature Committee. HLA-DPB1*0302 was identified in a single Sicilian individual by a combination of sequence-specific primers, reverse line sequence-specific oligonucleotide probing and DNA sequencing-based typing. The DPB1*0302 allele is most similar to the DPB1*3101 allele, differing by a single mismatch at nucleotide position 301 (T to G).
Sheldon
M H
MH
Dynal Biotech Ltd., Bromborough, Wirral, UK. melanie.sheldon@dynalbiotech.com
Azzaro
M P
MP
Sayer
D
D
Bunce
M
M
Sortino
G
G
D000483:Alleles; D001483:Base Sequence; D017931:DNA Primers / Q000737:chemistry; D005091:Exons; D006682:HLA-DP Antigens / Q000235:genetics*; D059868:HLA-DP beta-Chains; D006801:Humans; D008969:Molecular Sequence Data; D009841:Oligonucleotides / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D012802:Sicily
D017931:DNA Primers; D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen; C503975:HLA-DPB1*03:02 antigen; D009841:Oligonucleotides