Follow-up efficacy of integrative Chinese and Western drugs on localized scleroderma with vitamine B6 and Xuefu Zhuyu decoction.
OBJECTIVE
To investigate the therapeutic effects of vitamine B(6) (Vit B(6)) and Xuefu Zhuyu Decoction (XFZY, for activating blood circulation to remove stasis) in patients with localized scleroderma(LSD).


METHODS
Thirty-three patients were treated with XFZY and Vit B(6), with 15 cases taking orally prednisone acetate and 20 healthy volunteers as the control. Their level of soluble interleukin-2 receptor (sIL-2R) and tumor necrosis factor-alpha (TNF-alpha) in the patients with LSD before and after treatment were observed.


RESULTS
The level of sIL-2R and TNF-alpha in the serum from the patients with LSD were higher than those of healthy volunteers (P < 0.01). After treatment with Vit B(6) and XFZY, the level of sIL-2R and TNF-alpha from the patients with LSD decreased significantly (P < 0.01), but there were no difference between the group taking Vit B(6) plus XFZY and the group given prednisone.


CONCLUSIONS
The activating blood circulation to remove stasis approach in treating LSD with integrative Chinese and Western drugs got better results, and metabolic disorder of tryptophan might be correlated with the etiology of LSD.
Department of Dermatology, General Hospital of Beijing Military Region, China. wangwl6601@163.com
Wen-ling
WL
Wang
You-ming
YM
Su
Rong-ya
RY
Yang
Jie
J
Zhang
Yang
Y
Xu
D000293:Adolescent; D000328:Adult; D002648:Child; D018849:Controlled Clinical Trials as Topic; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D015375:Receptors, Interleukin-2 / Q000097:blood; D012594:Scleroderma, Localized / Q000097:blood / Q000188:drug therapy*; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D025101:Vitamin B 6 / Q000627:therapeutic use*
D004365:Drugs, Chinese Herbal; D005938:Glucocorticoids; D015375:Receptors, Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D025101:Vitamin B 6; D011241:Prednisone