A proof-of-concept study using [11C]flumazenil PET to demonstrate that pagoclone is a partial agonist.
A
A
Lingford-Hughes
S J
SJ
Wilson
A
A
Feeney
P G
PG
Grasby
D J
DJ
Nutt
D019540:Area Under Curve; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002247:Carbon Isotopes / Q000493:pharmacokinetics; D004347:Drug Interactions; D005442:Flumazenil / Q000493:pharmacokinetics*; D018757:GABA Modulators / Q000493:pharmacokinetics*; D006801:Humans; D054833:Isoindoles; D008140:Lorazepam / Q000494:pharmacology; D008297:Male; D009287:Naphthyridines / Q000494:pharmacology*; D049268:Positron-Emission Tomography / Q000379:methods
D002247:Carbon Isotopes; D018757:GABA Modulators; D054833:Isoindoles; D009287:Naphthyridines; C447412:pagoclone; D005442:Flumazenil; D008140:Lorazepam