Veno-occlusive disease of the liver associated with chronic myelomonocytic leukemia treated with vincristine and standard doses of cytarabine.
A unique case of a 72-year-old man with chronic myelomonocytic leukemia (CMML) who developed hepatic veno-occlusive disease (VOD) after treatment with a single dose of vincristine and standard doses of cytarabine is described. Unexpected peroneal nerve palsy suggestive of vincristine neurotoxicity occurred concurrently and pointed to vincristine as the most likely cause of the VOD. To the best of our knowledge, association between vincristine and hepatic VOD has not been previously described in chemotherapy-naive patients with CMML.
Boula
A M
AM
Department of Hematology, University Hospital of Heraklion, Heraklion, Crete, Greece.
Mantadakis
E
E
Xilouri
I M
IM
Christoforidou
A V
AV
Foudoulakis
A M
AM
Samonis
G
G
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D003561:Cytarabine / Q000627:therapeutic use; D018450:Disease Progression; D017809:Fatal Outcome; D006504:Hepatic Veno-Occlusive Disease / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D034141:Hypoalbuminemia; D015477:Leukemia, Myelomonocytic, Chronic / Q000150:complications* / Q000188:drug therapy; D008297:Male; D010291:Paresis; D051437:Renal Insufficiency; D013921:Thrombocytopenia; D014750:Vincristine / Q000009:adverse effects* / Q000627:therapeutic use
D003561:Cytarabine; D014750:Vincristine