Alpha1-antitrypsin deficiency-associated panniculitis: case report and review of treatment options.
Alpha(1)-antitrypsin deficiency, a relatively frequent mutation in the population, is associated with the development of panlobular emphysema and liver cirrhosis. The deficiency is in rare cases associated with the development of panniculitis, and very differentiated clinical courses have been reported in the literature. We report a case of panniculitis in a patient with alpha(1)-antitrypsin deficiency and describe briefly the pathophysiology of the disease and current treatment possibilities.
Department of Dermatology, Univeristy of Copenhagen, Gentofte Hospital, Niels Andersens Vej 65, DK 2900 Hellerup, Denmark. patriciagarcia@dadlnet.dk
P G
PG
Ortiz
B G
BG
Skov
E
E
Benfeldt
D000284:Administration, Oral; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D003622:Dapsone / Q000008:administration & dosage; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D015434:Panniculitis / Q000209:etiology* / Q000473:pathology; D014361:Trypsin Inhibitors / Q000008:administration & dosage; D000515:alpha 1-Antitrypsin / Q000008:administration & dosage; D019896:alpha 1-Antitrypsin Deficiency / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy
D000894:Anti-Inflammatory Agents, Non-Steroidal; D014361:Trypsin Inhibitors; D000515:alpha 1-Antitrypsin; D003622:Dapsone