Association of plasmid-mediated quinolone resistance with extended-spectrum beta-lactamase VEB-1.
Association of the plasmid-mediated quinolone resistance determinant QnrA and the bla(VEB-1) gene was identified in a single Enterobacter cloacae isolate from K.-Bicêtre, France, and in 11 out of 23 bla(VEB-1)-positive enterobacterial isolates from Bangkok, Thailand. This result may explain in part the association between quinolone and extended-spectrum beta-lactam resistance.
Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Université Paris XI, Le Kremlin-Bicêtre, France.
Laurent
L
Poirel
Marc
M
Van De Loo
Hedi
H
Mammeri
Patrice
P
Nordmann
D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D003227:Conjugation, Genetic; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D016972:Enterobacter cloacae / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D029968:Escherichia coli Proteins; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests / Q000379:methods; D008969:Molecular Sequence Data; D009268:Nalidixic Acid / Q000494:pharmacology; D010957:Plasmids / Q000235:genetics*; D015363:Quinolones / Q000494:pharmacology*; D017422:Sequence Analysis, DNA; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D015363:Quinolones; D009268:Nalidixic Acid; C119424:beta-lactamase VEB-1, E coli; D001618:beta-Lactamases