Selection of CD4+CD25+ regulatory T cells by self-peptides.
Regulatory T cells have been shown to prevent the development of autoimmune disease, and can modulate immune responses during infections or following tissue transplantation. Recently, the processes by which CD4+CD25+ regulatory T cells are produced during immune repertoire formation have begun to be elucidated. This review focuses on the role of self-peptides in mediating CD4+CD25+ regulatory T cell selection in the thymus. How self-peptides continue to have an important influence on the accumulation of CD4+CD25+ regulatory T cells in the periphery is also discussed.
Cozzo
C
C
The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.
Lerman
M A
MA
Boesteanu
A
A
Larkin
J
J
Jordan
M S
MS
Caton
A J
AJ
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D010455:Peptides / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000276:immunology*; D017634:Self Tolerance; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology
D010455:Peptides; D015375:Receptors, Interleukin-2