Surgery alone versus surgery and doxorubicin for the treatment of feline injection-site sarcomas: a report on 69 cases.
Sixty-nine cats were treated for injection-site sarcomas at the Veterinary Teaching Hospital of Grugliasco, Turin (Italy). The animals were divided into two subgroups: those subjected to four doxorubicin cycles combined with radical surgical excision 10 days after the second chemotherapy cycle (group A, 49 cats) or those treated with surgery alone (group B, 20 cats). Each cat was monitored for lung metastasis and local recurrence. In group A, 28 cats were alive at the end of the follow-up period. In this group, the recurrence rate was 40.8% while lung metastasis occurred in 12% of cats. In group B, eight animals were alive at the end of the follow-up period, while the rates of recurrence and metastasis were 35% and 10%. Neither the median disease-free interval nor the median overall survival was reached in either group. Moreover, there were no statistically significant differences between the two groups.
Martano
Marina
M
Department of Animal Pathology, Surgery Section, School of Veterinary Medicine, Via Leonardo da Vinci 44, 10095 Grugliasco, Turin, Italy. marina.martano@unito.it
Morello
Emanuela
E
Ughetto
Maura
M
Iussich
Selina
S
Petterino
Claudio
C
Cascio
Paolo
P
Buracco
Paolo
P
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D002415:Cats; D017024:Chemotherapy, Adjuvant / Q000662:veterinary; D018572:Disease-Free Survival; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D007558:Italy / Q000453:epidemiology; D008297:Male; D020360:Neoadjuvant Therapy / Q000662:veterinary; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000662:veterinary*; D012509:Sarcoma / Q000401:mortality / Q000662:veterinary*; D012983:Soft Tissue Neoplasms / Q000401:mortality / Q000662:veterinary*; D016019:Survival Analysis; D014611:Vaccination / Q000009:adverse effects / Q000662:veterinary
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin