How noise and coupling induce bursting action potentials in pancreatic {beta}-cells.
Unlike isolated beta-cells, which usually produce continuous spikes or fast and irregular bursts, electrically coupled beta-cells are apt to exhibit robust bursting action potentials. We consider the noise induced by thermal fluctuations as well as that by channel-gating stochasticity and examine its effects on the action potential behavior of the beta-cell model. It is observed numerically that such noise in general helps single cells to produce a variety of electrical activities. In addition, we also probe coupling via gap junctions between neighboring cells, with heterogeneity induced by noise, to find that it enhances regular bursts.
Jo
Junghyo
J
Department of Physics, Seoul National University, Seoul, Korea.
Kang
Hyuk
H
Choi
Moo Young
MY
Koh
Duk-Su
DS
D000200:Action Potentials; D000465:Algorithms; D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D004594:Electrophysiology; D017629:Gap Junctions / Q000378:metabolism; D006358:Hot Temperature; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D007477:Ions; D008564:Membrane Potentials; D008954:Models, Biological; D015233:Models, Statistical; D008962:Models, Theoretical; D013269:Stochastic Processes; D013696:Temperature; D013997:Time Factors
D007477:Ions