Enantioseparation of 1-phenyl-1-propanol on Chiralcel OD by supercritical fluid chromatography. I. Linear isotherm.
The supercritical fluid chromatography (SFC) separation of the enantiomers of 1-phenyl-1-propanol on the chiral stationary phase Chiralcel OD under linear conditions is studied. Supercritical CO2 modified with methanol is used as a mobile phase. The effect of modifier concentration, pressure and temperature is studied. An empirical isotherm to account for the effect of density of the mobile phase and modifier concentration has been used to model the experimental results. It was observed that the selectivity and resolution were higher at 30 degrees C as compared to those at 40 degrees C.
Rajendran
Arvind
A
ETH Swiss Federal Institute of Technology Zurich, Institute of Process Engineering, Sonneggstrasse 3, CH-8092 Zürich, Switzerland.
Mazzotti
Marco
M
Morbidelli
Massimo
M
D000327:Adsorption; D001592:Benzyl Alcohols / Q000302:isolation & purification*; D025924:Chromatography, Supercritical Fluid / Q000379:methods*; D013237:Stereoisomerism; D013816:Thermodynamics
D001592:Benzyl Alcohols; C007656:alpha-ethylbenzyl alcohol