Structural characterization of self-assembled monolayers of neoglycoconjugates using atomic force microscopy.
Thiolated self-assembled monolayers of carbohydrates may serve as useful polyvalent tools to mimic the organized presentation of such molecules at the cell surface. SAMs presenting the disaccharide maltose as a neoglycoconjugate were produced, and the structure was studied by high resolution atomic force microscopy. The molecules form highly ordered structures on a gold (111) surface, with lattice parameters determined by the linker moiety rather than the headgroup.
Tromas
Christophe
C
Laboratoire de Métallurgie Physique, SP2MI, Bld Marie et Pierre Curie, BP 30179, 86962 Futuroscope Cedex, France. christophe.tromas@univ-poitiers.fr
Eaton
Peter
P
Mimault
Jean
J
Rojo
Javier
J
Penadés
Soledad
S