Association of polymorphism of IL-10 and TNF-A genes with gastric cancer in Korea.
We performed this study to determine the role of polymorphisms of the IL-10 and TNF-alpha promoter genes in the carcinogenesis/pathogenesis of gastric cancer (GC) and peptic ulcer diseases (PUD) in Korea. A total of 232 patients with gastric diseases and 120 healthy controls were included. Polymorphisms of IL-10-1082/-592 gene and TNF-A-308 gene were genotyped by PCR-RFLP. There were no differences in genotypes and allele frequencies of IL-10 and TNF-A polymorphism between study group with GC or PUD and control group. In addition, there were no differences in genotypic frequencies according to H. pylori infection status, location of GC, and histologic type of GC. In conclusion, IL-10-1082/-592 and TNF-A-308 genetic polymorphisms may not be the important contributors to GC in Korea.
Division of Gastroenterology, Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University Medical Center, 445, Kildong, Kangdong-gu, Seoul 134-701, South Korea.
Ja Young
JY
Lee
Hak Yang
HY
Kim
Kyung Ho
KH
Kim
Seong Man
SM
Kim
Myoung Kuk
MK
Jang
Joon Yong
JY
Park
Jin Heon
JH
Lee
Jin-Ho
JH
Kim
Jae Young
JY
Yoo
D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D007723:Korea; D011110:Polymorphism, Genetic / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10