Synthesis of pentafluorophenylmethylamines via silicon Mannich reaction.
[reaction: see text] The three-component coupling of aldehydes, secondary amines, and methoxytris(pentafluorophenyl)silane, MeOSi(C(6)F(5))(3), affording pentafluorophenylmethylamines has been described. The generation of the five-coordinate silicate intermediate is believed to be the key feature responsible for the efficiency of the reaction.
Dilman
Alexander D
AD
N. D. Zelinsky Institute of Organic Chemistry, Moscow, Russian Federation. adil25@mail.ru
Belyakov
Pavel A
PA
Korlyukov
Alexander A
AA
Struchkova
Marina I
MI
Tartakovsky
Vladimir A
VA