Oxidation of N-substituted dopamine derivatives: irreversible formation of a spirocyclic product.
Oxidation of amide, urea and guanidinium derivatives of dopamine gives relatively stable ortho-quinones whereas oxidation of corresponding thioamide and amidinium derivatives rapidly and quantitatively gives novel bicyclic and spirocyclic products formed via the corresponding ortho-quinone.
Land
Edward J
EJ
School of Chemistry and Physics, Keele University, Keele, Staffordshire, UKST5 5BG.
Perona
Almudena
A
Ramsden
Christopher A
CA
Riley
Patrick A
PA