Extracellular bacterial pathogens and small GTPases of the Rho family: an unexpected combination.
Even in the case of extracellular bacterial pathogens, it is becoming increasingly clear that successful colonization does not limit itself to passive attachment on the surface of human cells; a dialogue takes place between bacteria and infected cells. These pathogens modulate cellular functions to their advantage, leading to survival and proliferation at the cell surface. Furthermore, there is increasing evidence that a variety of extracellular pathogens activate small GTPases of the Rho family during adhesion, placing these regulators at the center of the interaction between these bacteria and their infected host.
Duménil
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INSERM Unité 570, Faculté de Médecine Necker-Enfants Malades, 156 rue de Vaugirard, 75015 Paris, France. dumenil@necker.fr
Nassif
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D000818:Animals; D001419:Bacteria / Q000472:pathogenicity*; D001422:Bacterial Adhesion / Q000502:physiology*; D001424:Bacterial Infections / Q000382:microbiology*; D004789:Enzyme Activation; D006801:Humans; D010587:Phagocytosis; D014774:Virulence; D020741:rho GTP-Binding Proteins / Q000502:physiology*
D020741:rho GTP-Binding Proteins