Effect of enalapril on left ventricular diameters and exercise capacity in asymptomatic or mildly symptomatic patients with regurgitation secondary to mitral valve prolapse or rheumatic heart disease.
The effects of 12 months of therapy were evaluated in 47 mildly symptomatic patients with moderate to severe mitral valve regurgitation; 26 patients received enalapril and 21 received a placebo. Enalapril was associated with a significant reduction in left ventricular diameter and mitral regurgitation volume, with no evidence of change in systolic function indexes. However, enalapril did not hinder progressive aerobic impairment to effort.
Department of Valvular Heart Disease, University of São Paulo Medical School, São Paulo, Brazil. val_roney@incor.usp.br
Roney O
RO
Sampaio
Max
M
Grinberg
João J
JJ
Leite
Flávio
F
Tarasoutchi
William A
WA
Chalela
Marisa
M
Izaki
Guilherme S
GS
Spina
Eduardo Giusti
EG
Rossi
Charles
C
Mady
D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004656:Enalapril / Q000494:pharmacology* / Q000627:therapeutic use; D017079:Exercise Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000150:complications*; D008945:Mitral Valve Prolapse / Q000150:complications*; D010919:Placebos; D012214:Rheumatic Heart Disease / Q000150:complications*; D012720:Severity of Illness Index; D016896:Treatment Outcome; D020257:Ventricular Remodeling
D000806:Angiotensin-Converting Enzyme Inhibitors; D010919:Placebos; D004656:Enalapril