Mechercharmycins A and B, cytotoxic substances from marine-derived Thermoactinomyces sp. YM3-251.
A new cytotoxic substance named mechercharmycin A was isolated from marine-derived Thermoactinomyces sp. YM3-251. The structure of mechercharmycin A was determined by an X-ray crystallographic analysis to be cyclic peptide-like and bearing four oxazoles and a thiazole. Mechercharmycin B, a linear congener of mechercharmycin A, was also isolated from the same bacterium. Mechercharmycin A exhibited relatively strong antitumor activity, whereas mechercharmycin B exhibited almost no such activity.
Kaneo
K
Kanoh
Yoshihide
Y
Matsuo
Kyoko
K
Adachi
Hiroshi
H
Imagawa
Mugio
M
Nishizawa
Yoshikazu
Y
Shizuri
D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004151:Dipeptides / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008848:Micromonosporaceae / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D010080:Oxazoles / Q000302:isolation & purification / Q000494:pharmacology*; D010456:Peptides, Cyclic / Q000302:isolation & purification / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013844:Thiazoles / Q000302:isolation & purification / Q000494:pharmacology*
D000903:Antibiotics, Antineoplastic; D004151:Dipeptides; D010080:Oxazoles; D010456:Peptides, Cyclic; D013844:Thiazoles; C502107:mechercharmycin A; C502108:mechercharmycin B