KatA, the major catalase, is critical for osmoprotection and virulence in Pseudomonas aeruginosa PA14.
We demonstrate that among the three monofunctional catalases of Pseudomonas aeruginosa PA14, KatA and, to a lesser extent, KatB, but not KatE, are required for resistance to peroxide and osmotic stresses. KatA is crucial for adaptation to H2O2 stress and full virulence in both Drosophila melanogaster and mice. This dismantling of catalase roles represents a specialized catalytic system primarily involving KatA in responses to adverse environmental conditions.
Department of Life Science, Sogang University, Seoul 121-742, Korea.
Ji-Sun
JS
Lee
Yun-Jeong
YJ
Heo
Jeong K
JK
Lee
You-Hee
YH
Cho
D000818:Animals; D002374:Catalase / Q000502:physiology*; D004331:Drosophila melanogaster / Q000382:microbiology; D006861:Hydrogen Peroxide / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000201:enzymology* / Q000472:pathogenicity*; D014774:Virulence
D011189:Potassium Chloride; D006861:Hydrogen Peroxide; D002374:Catalase