[Incidence of febrile episodes in patients with multiple myeloma undergoing autologous peripheral blood stem cell transplantation].
BACKGROUND
Autologous peripheral blood stem cell transplantation (PBSCT) is a procedure frequently used as therapy for hematological malignancies, in which infectious complications are a major cause of morbimortality. The duration and intensity of neutropenia, indwelling central venous catheters, and mucosa chemotherapy-induced damage, contribute to increase infection rates. We have retrospectively review the incidence of febrile episodes and microbiological documented infections (MDI) in patients with multiple myeloma (MM) undergoing PBSCT.


METHODS
We have retrospectively analyzed 56 PBSCT in patients diagnosed of MM between 1995 and 2002 in our hospital.


RESULTS
34 patients showed fever: 19 fever of unknown origin; 5 clinically documented infections and 10 patients MDI. We isolated 5 pathogens gram negative and 4 gram positive. We observed 2 infections associated to indwelling central venous catheters and 1 MDI due to simplex Herpes Virus. Two patients died due to infectious complications.


CONCLUSIONS
The incidence of febrile episodes in our patients is similar to those previously reported as well, duration of neutropenia associated to PBSCT. We have observed a slightly higher incidence of gram negative pathogens.
Sevicio de Hematología y Hemoterapia, Hospital Universitario Miguel Servet, Zaragoza. csalvador3@vodafone.es
N
N
Fernández-Mosteirín
C
C
Salvador-Osuna
J J
JJ
Gimeno Lozano
M L
ML
Marco Lamata
M
M
Blasco Alberdi
D
D
Rubio Félix
M
M
Giralt Raichs
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects; D001424:Bacterial Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D002405:Catheterization, Central Venous / Q000009:adverse effects; D005260:Female; D005334:Fever / Q000453:epidemiology* / Q000209:etiology; D016905:Gram-Negative Bacterial Infections / Q000453:epidemiology / Q000209:etiology; D006561:Herpes Simplex / Q000453:epidemiology / Q000209:etiology; D017052:Hospital Mortality; D006801:Humans; D016867:Immunocompromised Host; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000601:surgery*; D009503:Neutropenia / Q000150:complications; D036102:Peripheral Blood Stem Cell Transplantation; D011183:Postoperative Complications / Q000453:epidemiology* / Q000209:etiology; D012189:Retrospective Studies; D019172:Transplantation Conditioning / Q000009:adverse effects; D014182:Transplantation, Autologous; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents