Commercialization of plant-based vaccines from research and development to manufacturing.
The benefits of using plant-based oral vaccines are discussed. Transgenic maize expressing an antigen of transmissible gastroenteritis virus (TGEV) is reported as a model to demonstrate efficacy. Young pigs that were fed the TGEV corn orally were protected against challenge with virulent TGEV. Additional parameters important in providing a reliable and consistent supply of plant-based vaccines are discussed. Finally, vaccines developed in maize are evaluated for their potential to contaminate either the food supply or the environment.
Howard
John A
JA
Biotechnology Institute, 5819 Stallion Ridge, College Station, TX 77845, USA. jhoward999@appliedbiotech.org
D000818:Animals; D003132:Commerce; D005761:Gastroenteritis, Transmissible, of Swine / Q000517:prevention & control*; D008517:Phytotherapy; D012107:Research Design; D013552:Swine; D005760:Transmissible gastroenteritis virus / Q000276:immunology*; D014481:United States; D014611:Vaccination / Q000662:veterinary*; D014765:Viral Vaccines; D003313:Zea mays
D014765:Viral Vaccines