[Functional morphology of adrenal cortex in aging rat under the influence of barocameral hypoxia].
The aim of the study was the assessment of adrenocorticocytes morphology in aging rat under the influence of hypobaric hypoxia. Adrenocorticocytes samples were collected from 11-18 months age 15 albino males under chronic hypobaric hypoxia of 60 days duration. The exposure time was 2 hours, pO2 was decreasing till 364-372 mm Hg. Histology, histochemistry and electronmicroscopic techniques were used to assess the weight and thickness of adrenal cortex. Remarkable fibrosis, decreasing of weight (14%) and thickness of zone glomerulosa (37%) and z. fasciculata (24%) were detected. Involution of cells and cellular organelles (lipid droplets), activation of scavenger cells and secondary lysosomes play a crucial role in secretory function depletion of glandular cells. There were revealed the giant mitochondria in Z. glomerulosa glandular cells. Morphological analysis have shown the involutive influence of hypoxia on the adrenal cortex conditioned by age.
A. Natishvili Institute of Experimental Morphology, Academy of Sciences of Georgia.
N
N
Chipashvili
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L
Gogiashvili
D000302:Adrenal Cortex / Q000473:pathology*; D000367:Age Factors; D000693:Anaerobiosis; D000818:Animals; D015687:Cell Hypoxia; D008297:Male; D009336:Necrosis; D051381:Rats