Activated protein C resistance due to factor V Leiden, elevated coagulation factor VIII and postoperative deep vein thrombosis in late breast reconstruction with a free TRAM flap: a report of two cases.
Thromboembolic complications can endanger free flap surgery and cause postoperative morbidity and even mortality. The underlying cause of thrombosis is multifactorial; major surgery may trigger hereditary thrombophilic disorders leading to overt thrombotic events. This paper reports two cases with postoperative deep vein thrombosis after late breast reconstruction with a TRAM flap. Both showed APC resistance due to factor V Leiden and elevated coagulation factor VIII. One of the patients also had an event of both arterial and venous anastomotic thrombosis postoperatively.
Department of Surgery, Gävle-Sandviken Central Hospital and Centre for Research and Development, Uppsala University, Gävleborg, S-801 88 Gävle, Sweden. eija.h.olsson@lg.se
Eija
E
Olsson
Patrik
P
Höijer
D020016:Activated Protein C Resistance / Q000097:blood / Q000150:complications*; D000328:Adult; D005165:Factor V / Q000032:analysis*; D005169:Factor VIII / Q000032:analysis*; D005260:Female; D006801:Humans; D016462:Mammaplasty; D008875:Middle Aged; D011183:Postoperative Complications; D013524:Surgical Flaps; D020246:Venous Thrombosis / Q000097:blood / Q000209:etiology*
C095381:factor V Leiden; D005165:Factor V; D005169:Factor VIII