The solution structure of a lasalocid A metal complex in lipophilic solvents.
Lasalocid A (LasNa), a common antibiotic in veterinary medicine, is a polyetheral ionophore, disrupting cation equilibria through the cell wall. By means of circular dichroism (in the UV and in the near-IR), paramagnetic NMR, and with the aid of the program PERSEUS, we determined the solution geometry of the 1:1 Las-Yb3+ complex in CD3CN and CDCl3, following a protocol similar to the one successfully used for the anthracycline-metal adduct. The resulting structure is in full agreement with the expectation of the ligand wrapping around the cation in a horseshoe shape. The oxygen atoms participate in the coordination either through a direct, first sphere, or a longer range interaction.
CNR-ICCOM sez. di Pisa, Dipartimento di Chimica e Chimica Industriale, via Risorgimento 35, 56126 Pisa, Italy.
Silvia
S
Ripoli
Simona
S
Scarano
Lorenzo
L
Di Bari
Piero
P
Salvadori
D007832:Lasalocid / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D012996:Solutions; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D008670:Metals; D012996:Solutions; D007832:Lasalocid