Use of high-content analysis for compound screening and target selection.
High-content analysis (HCA) has rapidly established itself as a core technology in drug discovery for secondary cell-based screening. When combined with our knowledge of genetics, HCA can provide a powerful tool for target validation, but excitingly, HCA may also enable the increased use of cellular assays in high-throughput screening for novel drug leads.
Rausch
Oliver
O
UCB Celltech, Granta Park, Great Abington, Cambridge, CB1 6GS, UK. oliver.rausch@ucb-group.com
D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods / Q000639:trends; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006801:Humans; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000639:trends