Novel synthesis and anti-inflammatory activities of 2,5-disubstituted-dioxacycloalkanes.
A novel stereospecific synthetic route to obtain a series of 2,5-disubstituted-dioxacycloalkanes is reported. Using an in vivo inhibition assay by monitoring xylene-induced ear edema in mice, the structure-activity relationship of the dioxacycloalkane compounds was studied, and compounds possessing high anti-inflammatory activity were identified.
College of Pharmaceutical Sciences, Capital University of Medical Sciences, Beijing 100054, PR China.
Lanrong
L
Bi
Yue
Y
Zhang
Ming
M
Zhao
Chao
C
Wang
Priscilla
P
Chan
Jeffrey B-H
JB
Tok
Shiqi
S
Peng
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D003516:Cycloparaffins / Q000138:chemical synthesis* / Q000494:pharmacology*; D004427:Ear Diseases / Q000139:chemically induced / Q000517:prevention & control; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008968:Molecular Conformation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014992:Xylenes / Q000037:antagonists & inhibitors / Q000737:chemistry
D000893:Anti-Inflammatory Agents; D003516:Cycloparaffins; D014992:Xylenes