[Regulation of phosphate balance in the kidney].
The reabsorption of phosphate filtered at glomeruli is mediated by sodium-dependent phosphate (Na/Pi) cotransporter families in the brush border membrane of the proximal tubuli. The type II a Na/Pi cotransporter plays the most important role for renal phosphate reabsorption and is regulated by several factors, e.g. parathyroid hormone (PTH) and fibroblastic growth factor-23. PTH induces endocytosis of the type II a Na/Pi cotransporter from the brush border membrane and subsequent lysosomal degradation, and the decrement of the type II a Na/Pi cotransporter in the brush border membrane leads the phosphate reabsorption inhibition.
Division of Nephrology, Department of Internal Medicine, Toho University Ohashi Medical Center.
Yoji
Y
Inishi
Hiroki
H
Hase
D006801:Humans; D007668:Kidney / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism*; D050608:Sodium-Phosphate Cotransporter Proteins; D050610:Sodium-Phosphate Cotransporter Proteins, Type II; D027981:Symporters / Q000502:physiology
D010710:Phosphates; D050608:Sodium-Phosphate Cotransporter Proteins; D050610:Sodium-Phosphate Cotransporter Proteins, Type II; D027981:Symporters