Synthesis of pentafluorophenylmethylamines via silicon Mannich reaction.
[reaction: see text] The three-component coupling of aldehydes, secondary amines, and methoxytris(pentafluorophenyl)silane, MeOSi(C(6)F(5))(3), affording pentafluorophenylmethylamines has been described. The generation of the five-coordinate silicate intermediate is believed to be the key feature responsible for the efficiency of the reaction.
N. D. Zelinsky Institute of Organic Chemistry, Moscow, Russian Federation. adil25@mail.ru
Alexander D
AD
Dilman
Pavel A
PA
Belyakov
Alexander A
AA
Korlyukov
Marina I
MI
Struchkova
Vladimir A
VA
Tartakovsky