Cytoprotectivity of Prunella vulgaris on doxorubicin-treated rat cardiomyocytes.
The cardioprotective effect of Prunella vulgaris ethylacetate fraction (PVEF) and its constituent rosmarinic acid (RA) was evaluated on isolated rat cardiomyocytes subjected to doxorubicin-induced oxidative stress. The cytoprotectivities of PVEF and RA were concentration-dependent in the range of 0.005 to 0.05 mg/ml and the effect of PVEF correlated with the RA content. Dexrazoxan (DE), used as positive control, was less effective than PVEF or RA.
Institute of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacký University, Hnĕvotínská 3, 775 15 Olomouc, Czech Republic. psotova@tunw.upol.cz
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J
Psotová
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S
Chlopcíková
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P
Miketová
V
V
Simánek
D000818:Animals; D000903:Antibiotics, Antineoplastic; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002934:Cinnamates / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D053630:Depsides; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin; D005260:Female; D008297:Male; D032383:Myocytes, Cardiac / Q000187:drug effects*; D018384:Oxidative Stress; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D031347:Prunella; D051381:Rats; D017207:Rats, Sprague-Dawley; D000097123:Rosmarinic Acid
D000903:Antibiotics, Antineoplastic; D002316:Cardiotonic Agents; D002934:Cinnamates; D053630:Depsides; D004317:Doxorubicin; D010936:Plant Extracts; D000097123:Rosmarinic Acid