Suppressive effects of dichloromethane fraction from the Areca catechu nut on naloxone-precipitated morphine withdrawal in mice.
In the present study, we investigated the effect of the dichloromethane fraction from Areca catechu nut on the severity of naloxone-precipitated morphine withdrawal in morphine-dependent mice. A single intraperitoneal injection of dichloromethane fraction at dose of 125 and 175 mg/kg significantly delayed the onset of withdrawal jumping behavior in a concentration-dependent manner compared to that of saline controls. The dichloromethane fractions also significantly decreased jumping numbers and faecal and urinary excretions during the withdrawal period.
Kumarnsit
Ekkasit
E
Department of Physiology, Faculty of Science, Prince of Songkla University, Songkhla Province, Thailand. ekumarnsit@yahoo.com
Keawpradub
Niwat
N
Vongvatcharanon
Uraporn
U
Sawangjaroen
Kitja
K
Govitrapong
Piyarat
P
D000701:Analgesics, Opioid / Q000009:adverse effects*; D000818:Animals; D001114:Areca; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D009020:Morphine / Q000009:adverse effects*; D009270:Naloxone; D009292:Narcotic Antagonists; D009754:Nuts; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013375:Substance Withdrawal Syndrome / Q000209:etiology / Q000517:prevention & control*
D000701:Analgesics, Opioid; D009292:Narcotic Antagonists; D010936:Plant Extracts; D009270:Naloxone; D009020:Morphine