Management of superficial leiomyosarcoma: a retrospective study of 10 cases.
BACKGROUND
Superficial leiomyosarcoma is a rare soft-tissue tumor. Management of this tumor, including pathological evaluations and therapies, is not clearly defined in the existing literature.


METHODS
Ten patients with superficial leiomyosarcoma treated in our institutes were recalled and scheduled for examination. Assessments were carried out according to clinical characteristics, therapies used, histological grade (based on the grading system of the Fédération Nationale des Centres de Lutte Contre Le Cancer), tumor-node-metastasis stage (using the American Joint Committee on Cancer staging system), recurrences rates, state of metastases, and the current condition of each patient.


RESULTS
No local recurrences or distant metastases were seen in eight patients with low-grade and early-stage disease, whereas two patients with high-grade and advanced-stage disease had recurrence and one of these two patients died of the disease.


CONCLUSIONS
This study indicates that evaluations using the Fédération Nationale des Centres de Lutte Contre Le Cancer grading system and the American Joint Committee on Cancer tumor staging system were useful. The authors advocate that surgical treatment of low-grade cutaneous leiomyosarcoma by complete excision with a narrow margin is adequate. For low-grade and early-state subcutaneous or soft-tissue leiomyosarcoma, wide excision with a minimum 2-cm lateral margin and one-tissue barrier deep margin is recommended. Management of high-grade leiomyosarcomas is still difficult; adequate wide excision may be the only option.
Department of Plastic and Reconstructive Surgery, Hokkaido University, Sapporo, Japan. tsutsu@med.hokudai.ac.jp
Arata
A
Tsutsumida
Tetsunori
T
Yoshida
Yuhei
Y
Yamamoto
Tomoo
T
Itoh
Hidehiko
H
Minakawa
Tsuneki
T
Sugihara
D000328:Adult; D001415:Back; D005153:Facial Neoplasms / Q000601:surgery*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000473:pathology / Q000601:surgery*; D008175:Lung Neoplasms / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D009367:Neoplasm Staging; D012189:Retrospective Studies; D012983:Soft Tissue Neoplasms / Q000473:pathology / Q000601:surgery*