Severe efavirenz-induced hypersensitivity syndrome (not-DRESS) with acute renal failure.
We report on a Subsaharian patient with HIV infection and disseminated tuberculosis who developed acute, severe hypersensitivity reaction to efavirenz including acute renal failure in addition to liver and lung involvement, in the absence of skin changes or blood eosinophilia.
Infectious Diseases and Tropical Medicine Unit, Department of Clinical and Surgical Sciences, University of Las Palmas de Gran Canaria, Plaza Dr Pasteur s/n, 35080 Las Palmas, Spain.
Alfonso
A
Angel-Moreno-Maroto
Laura
L
Suárez-Castellano
Michele
M
Hernández-Cabrera
Jose-Luis
JL
Pérez-Arellano
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000225:Adenine / Q000008:administration & dosage / Q000031:analogs & derivatives; D000328:Adult; D000480:Alkynes; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000009:adverse effects*; D048588:Benzoxazines / Q000009:adverse effects*; D003521:Cyclopropanes; D004342:Drug Hypersensitivity / Q000150:complications*; D005869:Ghana / Q000208:ethnology; D006678:HIV; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D017320:HIV Protease Inhibitors / Q000008:administration & dosage; D006801:Humans; D019259:Lamivudine / Q000008:administration & dosage; D008297:Male; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D063065:Organophosphonates / Q000008:administration & dosage; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D019438:Ritonavir / Q000008:administration & dosage; D000068698:Tenofovir; D014376:Tuberculosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy
D000480:Alkynes; D019380:Anti-HIV Agents; D048588:Benzoxazines; D003521:Cyclopropanes; D017320:HIV Protease Inhibitors; D063065:Organophosphonates; D018894:Reverse Transcriptase Inhibitors; D019259:Lamivudine; D000068698:Tenofovir; D000225:Adenine; C098320:efavirenz; D019438:Ritonavir