Rapidly-progressive glomerulonephritis in a patient with Behcet's disease: successful treatment with intravenous cyclophosphamide.
We report a case of rapidly-progressive glomerulonephritis complicating Behcet's disease (BD). A 44-year-old male has suffered from recurrent oral ulcers and retinal vasculitis developed 2 years ago. He complained of abdominal pain and papulopustular skin lesions. Multiple ulcers were seen on the colon on colonoscopy. Routine renal work-up revealed heavy proteinuria and hematuria. Renal biopsy demonstrated crescentic glomerulonephritis. Most symptoms improved after steroid therapy, except for urinary abnormalities. At this point, intravenous monthly cyclophosphamide pulse therapy was undergone. After the sixth pulse therapy, proteinuria and hematuria were dramatically improved and renal function was well preserved.
Division of Rheumatology, Department of Internal Medicine, Kangnam St. Mary's Hospital, The Catholic University of Korea, 505 Banpo-dong Seocho-ku, Seoul, 137-040, Korea.
Sung-Dong
SD
Kim
Sang-Hyon
SH
Kim
Hae-Rim
HR
Kim
Chong-Hyeon
CH
Yoon
Sang-Heon
SH
Lee
Sung-Hwan
SH
Park
Ho-Youn
HY
Kim
D000328:Adult; D001528:Behcet Syndrome / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D001707:Biopsy, Needle; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D005921:Glomerulonephritis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007262:Infusions, Intravenous; D007677:Kidney Function Tests; D008297:Male; D012720:Severity of Illness Index; D016896:Treatment Outcome
D003520:Cyclophosphamide