The CYP1A1*2a allele is an independent prognostic factor for acute myeloid leukemia.
Polymorphisms in carcinogen- and drug-metabolizing enzymes may increase the risk of acute myeloid leukemia (AML) and may influence prognosis. We report that the polymorphic variant of the cytochrome P450 CYP1A1*2A, present in 11.3% of patients, is an independent unfavorable prognostic factor for failure-free and overall survival in patients with AML.
Maria Teresa
MT
Voso
Francesco
F
D'Alo'
Daniela
D
Gumiero
Francesco
F
Guidi
Stefan
S
Hohaus
Giuseppe
G
Leone
D000208:Acute Disease; D000483:Alleles; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D003582:Cytogenetics; D018572:Disease-Free Survival; D020022:Genetic Predisposition to Disease; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000401:mortality; D011110:Polymorphism, Genetic; D011379:Prognosis; D012074:Remission Induction; D012306:Risk; D016896:Treatment Outcome
D019363:Cytochrome P-450 CYP1A1