[Hepatic alterations in patients with dengue].
Clinical features of Dengue are very variable due to multiple alterations induced by the virus in the organism. Increased levels of transaminases similar to those produced by the Hepatitis virus have been reported in patients with Dengue from hiperendemic zones in Asia. The objectives of this study were to determine alterations in the liver tests in patients with Dengue and to relate them to the disease, clinically and serologically. Clinical history, hemathological tests serum transaminases (ALT y AST) and bilirubin assays were performed in 62 patients with clinical and serological diagnosis of Dengue. According to clinical features 38.7% of the patients with classical (CD) and hemorrhagic (DHF) forms of Dengue reffered abdominal pain and 2 patients with DHF had ictericia and hepatomegaly. Laboratory test findings showed leucopenia in 72.5% in both forms of Dengue and of patients with DHF severe thrombocytopenia (< 50.000 platelets x mm3), long PT and PPT in 70.9%, 23.0% and 42.3%, respectively. Transaminase values five fold higher than the normal values (p < 0.005) were observed in 36.8% and 74.4% of patients with CD and DHF respectively; AST was predominant in both groups. Our results suggest liver damage during the course of Dengue. A differential diagnosis has to be done between the hepatic involvement of Dengue cases and others viral diseases with hepatic disfunctions.
Sección de Virología, Instituto de Investigaciones Clínicas, Facultad de Medicina, Universidad del Zulia, Apartado 23, Maracaibo 4001-A, Venezuela. yraimalarreal@yahoo.com
Yraima
Y
Larreal
Nereida
N
Valero
Jesús
J
Estévez
Ivette
I
Reyes
Mery
M
Maldonado
Luz Marina
LM
Espina
Julia
J
Arias
Eddy
E
Meleán
German
G
Añez
Ricardo
R
Atencio
D015746:Abdominal Pain / Q000209:etiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D003715:Dengue / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D003937:Diagnosis, Differential; D005260:Female; D006525:Hepatitis, Viral, Human / Q000175:diagnosis; D006529:Hepatomegaly / Q000209:etiology; D006801:Humans; D041781:Jaundice, Obstructive / Q000209:etiology; D008099:Liver / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D019595:Severe Dengue / Q000097:blood / Q000150:complications / Q000503:physiopathology*
D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin