Transcriptional analysis of the bla(CTX-M-2) gene in Salmonella enterica serovar Infantis.
Transcriptional organization of bla(CTX-M-2) present in a multiresistance plasmid of Salmonella enterica serovar Infantis suggests the presence of more than one promoter involved in the expression of the beta-lactamase gene. At least two bla(CTX-M-2)-specific mRNAs (near to 1 kb and 5 kb) were evidenced. Two +1 signals were detected at -22 bp and -59 bp of bla(CTX-M-2) defining two putative promoters.
Cátedra de Microbiología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
José A
JA
Di Conza
Gabriel O
GO
Gutkind
Marta E
ME
Mollerach
Juan A
JA
Ayala
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001483:Base Sequence; D024901:Drug Resistance, Multiple, Bacterial; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D008969:Molecular Sequence Data; D010957:Plasmids; D011401:Promoter Regions, Genetic; D019779:Salmonella enterica / Q000145:classification / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D017422:Sequence Analysis, DNA; D012703:Serotyping; D014158:Transcription, Genetic; D001618:beta-Lactamases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism
D000900:Anti-Bacterial Agents; C071167:beta-lactamase CTX-2; D001618:beta-Lactamases