Safety of trypan blue 1% and indocyanine green 0.5% in assisting visualization of anterior capsule during phacoemulsification in mature cataract.
OBJECTIVE
To evaluate the safety of trypan blue 1% and indocyanine green (ICG) 0.5% in assisting visualization of anterior capsule during phacoemulsification in mature cataract.


METHODS
Department of Ophthalmology, United Christian Hospital, Hong Kong, China.


METHODS
This prospective randomized clinical trial comprised 46 eyes with mature cataract receiving phacoemulsification and posterior chamber intraocular lens implantation. They were randomized into 3 groups (trypan blue, ICG, and control without stain). Visual acuity, endothelial cell count, corneal clarity, anterior chamber reaction, and intraocular pressure (IOP) were documented before surgery and 1 week, 1 month, and 3 months postoperatively. The absolute phaco time was also recorded.


RESULTS
There was no significant difference in absolute phaco time (P=.17), mean endothelial cell loss (P=.72 at 1 week, P=.43 at 1 month, and P=.60 at 3 months) and no significant correlation between the absolute phaco time and the change in endothelial cell count (P=.50 at 1 week, P=.10 at 1 month, and P=.60 at 3 months) in the 3 groups. None of the patients had postoperative IOP greater than 21 mm Hg. All eyes had clear corneas and a quiet anterior chamber 3 months after surgery.


CONCLUSIONS
Both trypan blue 1% and ICG 0.5% are safe for assisting visualization of the anterior capsule during phacoemulsification of mature cataract.
Department of Ophthalmology, United Christian Hospital, Hong Kong SAR, China.
Chong Fai
CF
Chung
Chan Chung
CC
Liang
Jimmy S M
JS
Lai
Ernie S F
ES
Lo
Dennis S C
DS
Lam
D019923:Capsulorhexis; D002386:Cataract / Q000175:diagnosis*; D002452:Cell Count; D004396:Coloring Agents; D004728:Endothelium, Corneal / Q000473:pathology; D006801:Humans; D007208:Indocyanine Green; D007903:Lens Capsule, Crystalline / Q000473:pathology*; D019654:Lens Implantation, Intraocular; D018918:Phacoemulsification; D011446:Prospective Studies; D012449:Safety; D013194:Staining and Labeling / Q000379:methods; D014343:Trypan Blue; D014792:Visual Acuity
D004396:Coloring Agents; D014343:Trypan Blue; D007208:Indocyanine Green