T-cell and chemokine receptor variation in south Amerindian populations.
The immune response of relatively small, endogamous populations is of special interest, because they may differ from those of large, ethnically diverse, urban groups. As a contribution to this area of investigation, we tested 99 individuals from two Brazilian native populations for two T-cell receptor gene segments (TCRBV3S1 and TCRBV18) and 241 subjects from eight tribes of this ethnic group in relation to the chemokine receptor CCR5delta32 allele. Differences in TCRBV3S1 and TCRBV18 prevalences of the Amerindians in relation to European- and African-derived individuals were not marked. We confirmed the absence of the CCR5delta32 allele in most groups, its presence in the Mura and Kaingang, probably because of European gene introgression.
Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Caixa Postal 15053, 91501-970 Porto Alegre, RS, Brazil.
Tabita
T
Hünemeier
Andrei G
AG
Neves
Igor
I
Nornberg
Kim
K
Hill
A Magdalena
AM
Hurtado
Francisco R
FR
Carnese
Alicia S
AS
Goicoechea
Mara H
MH
Hutz
Francisco M
FM
Salzano
José A B
JA
Chies
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001938:Brazil / Q000208:ethnology; D004247:DNA / Q000235:genetics*; D005787:Gene Frequency; D005819:Genetic Markers; D014644:Genetic Variation; D006801:Humans; D007199:Indians, South American / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011948:Receptors, Antigen, T-Cell / Q000097:blood / Q000235:genetics*; D019707:Receptors, Chemokine / Q000097:blood / Q000235:genetics*
D005819:Genetic Markers; D011948:Receptors, Antigen, T-Cell; D019707:Receptors, Chemokine; D004247:DNA