Closure of atrial septal defect in the adult. Cardiac remodeling is an early event.
BACKGROUND
Study aimed to describe the extent and the temporal profile of cardiac remodeling after atrial septal defect closure in the adult.


METHODS
Prospective and longitudinal echocardiographic assessment of right and left heart size before and after (1 day-1 week/1/4/12 months) surgical or catheter-based atrial septal closure in 39 adults (age 54+/-15 years).


RESULTS
Right ventricular and atrial sizes were markedly reduced, left ventricular size increased and left atrial size remained unchanged after closure. Older age and a history of atrial fibrillation reduced the potential to normalize right and left atrial size after closure. The greater part of the changes occurred very early, in the 1st day/1st week. From then on the speed of change gradually diminished and after 4 months no important changes were observed. The mode of closure did not influence the degree or the pace of the remodeling.


CONCLUSIONS
Cardiac remodeling after atrial septal closure in the adult is a common and early event that seems by and large completed within the first half year after closure. The ventricles seem to have a higher capacity of remodeling than the atria in this setting. The mode of closure does not seem to significantly impact remodeling.
Department of Cardiology, Lund University, Lund University Hospital, SE-221 85 LUND, Sweden. Ulf.Thilen@skane.se
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D000328:Adult; D000368:Aged; D016280:Atrial Function, Right; D005260:Female; D006325:Heart Atria / Q000473:pathology; D006344:Heart Septal Defects, Atrial / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling