Establishment of a human myeloid cell line with trisomy 8 derived from overt leukemia following myelodysplastic syndrome.
A human myeloid cell line with trisomy 8 was newly established from overt myelogenous leukemia arising in myelodysplastic syndrome. The cells of this cell line showed immature myelocyte characteristics. The karyotype retained trisomy 8. This cell line could improve understanding of the pathophysiology of myelogenous leukemia with trisomy 8.
Hiroshi
H
Matsuoka
Tohru
T
Murayama
Tamio
T
Koizumi
Ryuichiro
R
Nishimura
Ryuji
R
Kawaguchi
Toshitaro
T
Nakagawa
D000368:Aged; D018929:Cell Culture Techniques / Q000379:methods*; D045744:Cell Line, Tumor; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000209:etiology / Q000235:genetics*; D008297:Male; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D022423:Myeloid Cells / Q000166:cytology*; D014314:Trisomy