No adverse effects of adjuvant chemotherapy on hippocampal volume in Japanese breast cancer survivors.
We investigated the adverse effects of adjuvant chemotherapy on the hippocampus in Japanese breast cancer survivors with (n=44) and without (n=31) adjuvant chemotherapy. There were no significant differences in hippocampal volume (magnetic resonance imaging) or additionally in memory function (Wechsler Memory Scale-Revised) between the two groups.
Psycho-Oncology Division, National Cancer Center Research Institute, 6-5-1 Kashiwanoha, Kashiwa 277-8577, Japan.
Eisho
E
Yoshikawa
Yutaka
Y
Matsuoka
Masatoshi
M
Inagaki
Tomohito
T
Nakano
Tatsuo
T
Akechi
Makoto
M
Kobayakawa
Maiko
M
Fujimori
Naoki
N
Nakaya
Nobuya
N
Akizuki
Shigeru
S
Imoto
Koji
K
Murakami
Yosuke
Y
Uchitomi
D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000494:pharmacology* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D006624:Hippocampus / Q000187:drug effects*; D006801:Humans; D007564:Japan; D008279:Magnetic Resonance Imaging; D008408:Mastectomy; D008569:Memory Disorders / Q000139:chemically induced* / Q000175:diagnosis; D008875:Middle Aged; D009483:Neuropsychological Tests; D009929:Organ Size / Q000187:drug effects; D017741:Survivors
D000970:Antineoplastic Agents