Stanol esters as a component of maximal dietary therapy in the National Cholesterol Education Program Adult Treatment Panel III report.
Use of plant stanols/sterols in forms that are sufficiently bioavailable for therapeutic effect should be a key element of maximal dietary therapy. This principle was recognized by National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) and has been amply confirmed by experimental studies in humans. Since the introduction of statins, dietary therapy for control of elevated low-density lipoprotein (LDL) cholesterol levels has received less attention. The time has come, however, to reassert the importance of maximal dietary therapy as a cost-effective means for treatment of elevated LDL concentrations and for lifetime prevention of coronary heart disease.
Center for Human Nutrition, and the Department of Clinical Nutrition, University of Texas, Southwestern Medical Center at Dallas, Dallas, Texas 75390-9052, USA. Scott.Grundy@UTSouthwestern.edu
Scott M
SM
Grundy
D008078:Cholesterol, LDL / Q000378:metabolism; D003131:Combined Modality Therapy; D003324:Coronary Artery Disease / Q000517:prevention & control; D003362:Cost-Benefit Analysis; D006801:Humans; D006937:Hypercholesterolemia / Q000178:diet therapy* / Q000188:drug therapy*; D010840:Phytosterols / Q000627:therapeutic use*; D012855:Sitosterols / Q000627:therapeutic use*; D016896:Treatment Outcome
D008078:Cholesterol, LDL; D010840:Phytosterols; D012855:Sitosterols; C407042:plant stanol ester