Glycosidase inhibition by 1-glycosyl-4-phenyl triazoles.
1-Glycosyl-4-phenyl triazoles have been prepared via a copper-mediated [3+2] cycloaddition of glycosyl azides with phenylacetylene. These triazoles have been evaluated for their ability to inhibit the enzymatic activity of glycosidases.
Department of Chemistry, Brown University, Providence, RI 02912, USA.
Lauren L
LL
Rossi
Amit
A
Basu
D000114:Acetylene / Q000031:analogs & derivatives / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006027:Glycosides / Q000138:chemical synthesis / Q000494:pharmacology; D006868:Hydrolysis; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis / Q000494:pharmacology
D001386:Azides; D004791:Enzyme Inhibitors; D006027:Glycosides; D014230:Triazoles; C044736:phenylacetylene; D003300:Copper; D006026:Glycoside Hydrolases; D000114:Acetylene