Family-based association studies of lipid gene polymorphisms in coronary artery disease.
Dysfunction of lipid-metabolizing proteins is implicated in the pathogenesis of coronary artery disease. Single nucleotide polymorphisms in genes that encode sterol regulatory binding protein-1a, adenosine triphosphate binding cassette-A1, hepatic lipase, lipoprotein lipase, and cholesteryl ester transfer protein were assessed as potential markers of disease susceptibility in a family-based study of 1,012 patients from 386 families. Association between single nucleotide polymorphisms and coronary artery disease was tested by the combined transmission disequilibrium test/sib transmission disequilibrium test and pedigree disequilibrium test. After Bonferroni's correction, the pedigree disequilibrium test demonstrated significant excess transmission (p <0.0083) to affected patients of the hepatic lipase -514 T allele, which suggests that this may constitute a novel disease-susceptibility locus.
Department of Medicine, Queen's University Belfast, Belfast, Northern Ireland, UK.
Adrian
A
Allen
Christine
C
Belton
Chris
C
Patterson
Paul
P
Horan
Paul
P
McGlinchey
Mark
M
Spence
Alun
A
Evans
Damian
D
Fogarty
Pascal
P
McKeown
D000328:Adult; D017668:Age of Onset; D003324:Coronary Artery Disease / Q000209:etiology / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008049:Lipase / Q000235:genetics*; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide
D005819:Genetic Markers; C504173:LIPC protein, human; D008049:Lipase