New HIV-1 replication inhibitors of the styryquinoline class bearing aroyl/acyl groups at the C-7 position: synthesis and biological activity.
Novel variants of HIV-1 replication inhibitors of the styrylquinoline class harboring aroyl/acyl group at the C-7 position have been synthesized. In sharp contrast with styrylquinolines bearing a carboxylic acid group at C-7, these compounds proved to be inactive toward HIV-1 integrase in in vitro assays.
Normand-Bayle
Marie
M
Unité Associée au CNRS, UMR 8076, Faculté de Pharmacie, 5, rue J.-B. Clément, 92290 Châtenay-Malabry, France.
Bénard
Christophe
C
Zouhiri
Fatima
F
Mouscadet
Jean-François
JF
Leh
Hervé
H
Thomas
Claire-Marie
CM
Mbemba
Gladys
G
Desmaële
Didier
D
d'Angelo
Jean
J
D000215:Acylation; D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D019427:HIV Integrase / Q000378:metabolism; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects*
D019380:Anti-HIV Agents; D011804:Quinolines; D019427:HIV Integrase