3-Thio-1,2,4-triazoles, novel somatostatin sst2/sst5 agonists.
Novel 3-thio-1,2,4-triazoles have been obtained via a solution-phase parallel synthesis strategy, affording potent non-peptidic human somatostatin receptor subtypes 2 and 5 agonists.
Contour-Galcéra
Marie-Odile
MO
Ipsen Research Laboratories, Institut Henri Beaufour, 5 Avenue du Canada, F-91966 Les Ulis Cédex, France. m-odile.galcera@ipsen.com
Sidhu
Alban
A
Plas
Pascale
P
Roubert
Pierre
P
D001665:Binding Sites; D000242:Cyclic AMP / Q000037:antagonists & inhibitors / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015394:Molecular Structure; D017481:Receptors, Somatostatin / Q000819:agonists*; D013004:Somatostatin / Q000378:metabolism* / Q000494:pharmacology; D013440:Sulfides / Q000138:chemical synthesis* / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis / Q000494:pharmacology
D017481:Receptors, Somatostatin; D013440:Sulfides; D014230:Triazoles; D013004:Somatostatin; C094573:somatostatin receptor 5; C093733:somatostatin receptor 2; D000242:Cyclic AMP