Association of a COL1A1 polymorphism with lumbar disc disease in young military recruits.
BACKGROUND
Lumbar disc disease (LDD), one of the most common conditions for which patients seek medical care, has been associated with sequence changes of the COL genes. COL1A1, however, has not been studied in young patients with LDD; COL1A1 polymorphisms have been associated with bone mineral density (BMD) in several populations and with LDD in older adults.


OBJECTIVE
To study COL1A1 polymorphisms in young Greek army recruits with LDD.


METHODS
These young soldiers were diagnosed with early LDD at the time of their presentation to a military training site. All patients had radiological confirmation of their disease; a control group was also studied.


METHODS
Sp1-binding site polymorphism of the COL1A1 gene was investigated by standard methods.


RESULTS
There was an increased frequency of the "ss" genotype (33.3%) in LDD patients; none of the controls had this genotype. In addition, a significantly smaller number of controls was heterozygotes for this allele.


CONCLUSIONS
A previously studied sequence change of the regulatory region of the COL1A1 gene, the same as has previously been associated with low BMD in many populations and LDD in older adults, showed a strong association with LDD in young male soldiers who were recently diagnosed with this disease.
C
C
Tilkeridis
T
T
Bei
S
S
Garantziotis
C A
CA
Stratakis
D000328:Adult; D000483:Alleles; D015519:Bone Density; D024042:Collagen Type I / Q000235:genetics*; D000090602:Collagen Type I, alpha 1 Chain; D004252:DNA Mutational Analysis; D020022:Genetic Predisposition to Disease; D006115:Greece; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007403:Intervertebral Disc / Q000473:pathology*; D017116:Low Back Pain / Q000209:etiology; D008161:Lumbosacral Region; D008279:Magnetic Resonance Imaging; D008297:Male; D008889:Military Personnel; D011110:Polymorphism, Genetic; D013122:Spinal Diseases / Q000175:diagnosis / Q000235:genetics*
D024042:Collagen Type I; D000090602:Collagen Type I, alpha 1 Chain