Preoperative feeding preserves heart function and decreases oxidative injury in rats.
OBJECTIVE
The nutritional status of a patient has been implicated as an important factor in the development of postoperative complications. Fasting before an operation may have detrimental effects on the metabolic state. We hypothesized that there was a positive correlation between preoperative nutritional status and postoperative organ function.


METHODS
Preoperative feeding was compared with fasting with respect to effects on organ function and biochemical parameters in an animal model of extensive large abdominal surgery. Male Wistar rats were fed ad libitum or fasted for 16 h, after which the arteria mesenterica superior was clamped for 60 min followed by 180 min of reperfusion.


RESULTS
After the ischemic period, heart function was significantly better in animals that were fed ad libitum than in fasted animals. Moreover, after intestinal ischemia and reperfusion, fed rats showed significantly higher levels of intestinal adenosine triphosphate and a significantly higher malondialdehyde concentration in the intestine and lung than did fasted rats. The ratio of adenosine triphosphate to adenosine diphosphate in the liver, an indicator of energy status, in fed rats was similar to that in a sham group, whereas fasted animals showed a significantly lower value.


CONCLUSIONS
Preoperative nutrition in contrast to fasting may attenuate ischemia/reperfusion-induced injury and preserve organ function in the rat.
van Hoorn
Danny E C
DE
Department BMR, Numico Research, Wageningen, The Netherlands.
Boelens
Petra G
PG
van Middelaar-Voskuilen
Mariska C
MC
Nijveldt
Robert J
RJ
Prins
Hubert
H
Bouritius
Hetty
H
Hofman
Zandrie
Z
M'rabet
Laura
L
van Leeuwen
Paul A M
PA
van Norren
Klaske
K
D000818:Animals; D002302:Cardiac Output; D004195:Disease Models, Animal; D005215:Fasting; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006339:Heart Rate; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000098:blood supply; D007511:Ischemia / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D007668:Kidney / Q000503:physiopathology; D008099:Liver / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009102:Multiple Organ Failure / Q000517:prevention & control*; D009752:Nutritional Status; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D011300:Preoperative Care / Q000379:methods*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000517:prevention & control*; D012307:Risk Factors
D005230:Fatty Acids, Nonesterified; D008315:Malondialdehyde