A novel aspochalasin with HIV-1 integrase inhibitory activity from Aspergillus flavipes.
A novel aspochalasin, aspochalasin L (1), was isolated from the fermentation broth of a soil-derived fungal culture identified as Aspergillus flavipes (Deuteromycota). Structure elucidation of 1 was accomplished by detailed spectroscopic data analyses and by comparison with related cytochalasins. Aspochalasin L demonstrated activity against HIV integrase with an IC50 of 71.7microM.
Cerylid Biosciences, 576 Swan Street, Richmond, Victoria 3121, Australia. simone.rochfort@dpi.vic.gov.au
Simone
S
Rochfort
Joanne
J
Ford
Simon
S
Ovenden
Soo San
SS
Wan
Samantha
S
George
Howard
H
Wildman
R Murray
RM
Tait
Barbara
B
Meurer-Grimes
Susan
S
Cox
Jonathan
J
Coates
David
D
Rhodes
D001230:Aspergillus / Q000737:chemistry / Q000378:metabolism*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003470:Culture Media; D003572:Cytochalasins / Q000302:isolation & purification / Q000494:pharmacology*; D005285:Fermentation; D019428:HIV Integrase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects / Q000201:enzymology*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
D003470:Culture Media; D003572:Cytochalasins; D019428:HIV Integrase Inhibitors; C502106:aspochalasin L