Fluorescent profiling of natural product producers.
The identification of natural product producer organisms remains a problem for both isolation and natural product classification. A concise screen is developed through fluorescent modification of a set of natural products that offer a common activity. Through real-time multicolor microscopy, the processing, storage, and effects of a natural product are rapidly screened at the level of the strain and individual organism.
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093-0204, USA.
Joel S
JS
Sandler
William
W
Fenical
Brian M
BM
Gulledge
A Richard
AR
Chamberlin
James J
JJ
La Clair
D000818:Animals; D001688:Biological Products / Q000032:analysis* / Q000096:biosynthesis; D001709:Biotechnology / Q000379:methods*; D004141:Dinoflagellida / Q000378:metabolism / Q000648:ultrastructure; D005456:Fluorescent Dyes / Q000138:chemical synthesis; D012680:Sensitivity and Specificity
D001688:Biological Products; D005456:Fluorescent Dyes