A 10-item smell identification scale related to risk for Alzheimer's disease.
University of Pennsylvania Smell Identification Test data from control subjects (n = 63), patients with mild cognitive impairment (n = 147), and patients with Alzheimer's disease (n = 100) were analyzed to derive an optimal subset of items related to risk for Alzheimer's disease (ie, healthy through mild cognitive impairment to early and moderate disease stages). The derived 10-item scale performed comparably with the University of Pennsylvania Smell Identification Test in classifying subjects, and it strongly predicted conversion to Alzheimer's disease on follow-up evaluation in patients with mild cognitive impairment. Independent replication is needed to validate these findings.
Tabert
Matthias H
MH
Department of Biological Psychiatry, New York State Psychiatric Institute, New York, NY, USA. mht35@columbia.edu
Liu
Xinhua
X
Doty
Richard L
RL
Serby
Michael
M
Zamora
Diana
D
Pelton
Gregory H
GH
Marder
Karen
K
Albers
Mark W
MW
Stern
Yaakov
Y
Devanand
D P
DP
D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis*; D003072:Cognition Disorders / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors; D012684:Sensory Thresholds / Q000502:physiology; D012903:Smell / Q000502:physiology*