Macrophages and dendritic cells treatment of spinal cord injury: from the bench to the clinic.
The failure of the spinal cord to recover after injury has been associated with the immune privilege mechanism that suppresses immune activity throughout the central nervous system. Primed macrophages and dendritic cells were shown to promote neurological recovery in preclinical models of spinal cord injury. A cell therapy consisting of autologous incubated macrophages is now being tested on spinal cord injury patients in clinical trials.
Department Neurophysiology, Weizmann Institute of Science, Rehovot, Israel.
M
M
Schwartz
E
E
Yoles
D000818:Animals; D002986:Clinical Trials as Topic; D003713:Dendritic Cells / Q000637:transplantation*; D006801:Humans; D008264:Macrophages / Q000637:transplantation*; D009416:Nerve Regeneration; D010865:Pilot Projects; D051381:Rats; D020127:Recovery of Function; D012106:Research; D013119:Spinal Cord Injuries / Q000175:diagnosis / Q000534:rehabilitation* / Q000601:surgery*; D016896:Treatment Outcome