The effect of overnight contact lens corneal reshaping on higher-order aberrations and best-corrected visual acuity.
OBJECTIVE
The purpose of this study is to determine the effect of higher-order aberrations after Corneal Refractive Therapy (CRT) on best-corrected visual acuity (BCVA) and the impact of pupil size on BCVA.


METHODS
High-contrast (HC) and low-contrast (LC) Bailey-Lovie BCVA was measured in the morning before and after pupil dilation on 20 myopes (mean spherical equivalent -3.11 D +/- 0.96 D) under age 40. BCVA was measured again in the afternoon after dilation. Dilated am and pm aberrations were measured using the Complete Ophthalmic Analysis System (WaveFront Sciences). Patients were fit with CRT lenses in each eye. One month after finalizing the lens fit, BCVA and aberration testing were repeated. Average higher-order RMS error (third to sixth order), spherical aberration, third-, fourth-, fifth-, and sixth-order RMS error were calculated at each visit for a 3-mm and 5-mm pupil. BCVA and aberration data were analyzed using a repeated measures analysis of variance. Linear regression was used to describe the relationship between aberrations and BCVA reductions after CRT.


RESULTS
Mean refractive error changed by +3.33 D +/- 0.96 D. No clinically significant changes were found in HC BCVA post-CRT, whereas LC BCVA reductions of 0.07 logarithm of the minimum angle of resolution (logMAR) (nondilated, p = 0.002) and 0.12 logMAR (dilated, p < 0.001) were found. No additional decrease in HC BCVA was found after pupil dilation, whereas a mean additional decrease of 0.08 logMAR in LC BCVA was found with dilation post-CRT (p = 0.013). Higher-order RMS error increased for both 3-mm and 5-mm pupils (p < 0.0001) and remained stable between measurements. Spherical aberration increased for 5-mm pupils after CRT (p < 0.0001). For a 5-mm pupil, a 0.1-mum increase in spherical aberration was associated with an additional decrease in LC BCVA after pupil dilation post-CRT of 0.056 logMAR (R = 0.382, p = 0.004).


CONCLUSIONS
CRT results in reduced low-contrast BCVA as a result of increased higher-order aberrations. Higher-order aberrations appear to be relatively stable after CRT. Spherical aberration appears to drive additional low-contrast BCVA losses as pupil size increases.
The Ohio State University College of Optometry, Columbus, Ohio 43210, USA. dberntsen@optometry.osu.edu
David A
DA
Berntsen
Joseph T
JT
Barr
G Lynn
GL
Mitchell
D000328:Adult; D002940:Circadian Rhythm; D003261:Contact Lenses / Q000009:adverse effects*; D003315:Cornea; D019781:Corneal Topography; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D009216:Myopia / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D011680:Pupil; D012029:Refraction, Ocular; D013194:Staining and Labeling; D014792:Visual Acuity