Ultrahigh density microarrays of solid samples.
We present a sectioning and bonding technology to make ultrahigh density microarrays of solid samples, cutting edge matrix assembly (CEMA). Maximized array density is achieved by a scaffold-free, self-supporting construction with rectangular array features that are incrementally scalable. This platform technology facilitates arrays of >10,000 tissue features on a standard glass slide, inclusion of unique sample identifiers for improved manual or automated tracking, and oriented arraying of stratified or polarized samples.
LeBaron
Matthew J
MJ
Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University Medical Center, NRB E504, 3970 Reservoir Rd. NW, Washington, DC 20057-1469, USA.
Crismon
Heidi R
HR
Utama
Fransiscus E
FE
Neilson
Lynn M
LM
Sultan
Ahmed S
AS
Johnson
Kevin J
KJ
Andersson
Eva C
EC
Rui
Hallgeir
H
D004867:Equipment Design; D019544:Equipment Failure Analysis; D046228:Microarray Analysis / Q000295:instrumentation / Q000379:methods*; D008867:Microtomy / Q000295:instrumentation / Q000379:methods*; D013048:Specimen Handling / Q000295:instrumentation / Q000379:methods*; D046509:Tissue Culture Techniques / Q000295:instrumentation / Q000379:methods*; D016610:Tissue Embedding / Q000295:instrumentation / Q000379:methods*