Bioadhesive properties of a polyaminoacidic hydrogel: evaluation by ATR FT-IR spectroscopy.
The bioadhesive properties of a novel chemical hydrogel based on a polymer of protein-like structure, have been investigated by using ATR FT-IR spectroscopy. In particular, the copolymer PHG obtained by partial derivatization of PHEA with GMA was chemically crosslinked by UV irradiation at 313 nm. Crosslinked PHG was treated with water to obtain a swelled sample, named PHG-UV gel, that was brought into contact with a phosphate buffer/citric acid solution at pH 7.0 in the absence or in the presence of mucin at various concentrations (0.01, 0.1 and 1 wt.-%). Preliminary dynamic swelling studies have evidenced the occurrence of an interaction between the PHG-UV gel and the glycoprotein. This result was confirmed by ATR FT-IR measurements. A diffusion model using a solution of Ficks' second law was employed to determine the diffusion coefficient of water into PHG-UV gel as a consequence of adsorption and/or interdiffusion which occur at the PHG-UV gel/mucin solution interface. Experimental results suggest a potential use of PHG-UV gel to prepare bioadhesive devices.
Dipartimento di Ingegneria e Tecnologie Agro-Forestali, Università degli Studi di Palermo, Viale delle Scienze 13, 90128 Palermo, Italy.
Filippo
F
Saiano
Giovanna
G
Pitarresi
Delia
D
Mandracchia
Gaetano
G
Giammona
D000269:Adhesives / Q000737:chemistry*; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry*; D006868:Hydrolysis; D010777:Photochemistry; D011073:Polyamines / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D014466:Ultraviolet Rays
D000269:Adhesives; D020100:Hydrogels; D011073:Polyamines