A pilot study of the effects of sildenafil on stool characteristics, colon transit, anal sphincter function, and rectal sensation in healthy men.
Nitric oxide is an important mediator of gut smooth muscle relaxation and visceral sensation. Sildenafil results in stimulation of the nitric oxide-cyclic GMP pathway. We sought to determine the effects of daily sildenafil administration on colorectal function. Over a 4-week period, sildenafil was administered during weeks 2 and 3. Stool frequency and consistency were assessed daily. Anorectal manometry, rectal sensation, and colon transit testing were performed at the end of weeks 1 and 3. Ten healthy men were studied. No significant differences in segmental or total colon transit time were noted; however, significant changes in stool frequency and trends toward decreased stool consistency were noted during sildenafil use. A trend toward reduced resting anal sphincter pressure was seen after sildenafil. Rectal volumes to first sensation and desire to defecate were significantly increased after sildenafil on test day 2 only. Additionally, volumes to desire to defecate and maximal tolerable volume were significantly increased before sildenafil on test day 2 compared to before sildenafil on test day 1. We conclude that daily administration of sildenafil is well tolerated and results in alterations in colorectal function.
Division of Gastroenterology and Hepatology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.
Mark
M
Milone
John K
JK
DiBaise
D000328:Adult; D001003:Anal Canal; D003106:Colon / Q000187:drug effects; D003672:Defecation / Q000187:drug effects*; D005243:Feces; D005772:Gastrointestinal Transit / Q000187:drug effects*; D006801:Humans; D007420:Intestine, Large / Q000187:drug effects*; D008297:Male; D008365:Manometry; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D010865:Pilot Projects; D010879:Piperazines / Q000494:pharmacology*; D011687:Purines; D012007:Rectum / Q000187:drug effects; D012677:Sensation / Q000187:drug effects; D000068677:Sildenafil Citrate; D013450:Sulfones
D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D009569:Nitric Oxide; D000068677:Sildenafil Citrate