Studies on the apoptotic activity of natural and synthetic retinoids: discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells.
New terphenyl derivatives have been synthesized and tested for their effect on cell survival in serum-free cultures. These compounds protected HL60 cells from death and supported their growth with an activity higher than that of the natural 14-hydroxy-retro-retinol. Terphenyls 26 and 28 also possess antiapoptotic activity on neuronal cells, proving them as possible candidates for the treatment of neurodegenerative and ischemic diseases.
Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Via Fossato di Mortara 17-19, 44100 Ferrara, Italy. smd@dns.unife.it
Daniele
D
Simoni
Giuseppe
G
Giannini
Marinella
M
Roberti
Riccardo
R
Rondanin
Riccardo
R
Baruchello
Marcello
M
Rossi
Giuseppina
G
Grisolia
Francesco Paolo
FP
Invidiata
Stefania
S
Aiello
Silvia
S
Marino
Sabrina
S
Cavallini
Anna
A
Siniscalchi
Nicola
N
Gebbia
Lucia
L
Crosta
Stefania
S
Grimaudo
Vincenzo
V
Abbadessa
Antonietta
A
Di Cristina
Manlio
M
Tolomeo
D017209:Apoptosis / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D018922:HL-60 Cells; D006801:Humans; D007202:Indicators and Reagents; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D012176:Retinoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D007202:Indicators and Reagents; D012176:Retinoids