Gastrointestinal injury from NSAID therapy. How to reduce the risk of complications.
Use of nonsteroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin is accompanied by risk of upper and lower gastrointestinal (GI) complications, some of which can be serious or even fatal. Management strategies to reduce this risk include gastroprotective pharmacotherapy, use of safer NSAIDs, and eradication of Helicobacter pylori infection. In this article, Dr Lanas summarizes the GI risks associated with NSAID and low-dose aspirin therapy and weighs the efficacy of current risk management strategies.
Lanas
Angel
A
Service of gastroenterology, University Hospital, Institute of Health Sciences of Aragon, Zaragoza, Spain.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D004415:Dyspepsia / Q000139:chemically induced; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced* / Q000382:microbiology / Q000517:prevention & control; D041981:Gastrointestinal Tract / Q000187:drug effects; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy; D016480:Helicobacter pylori; D006801:Humans; D010437:Peptic Ulcer / Q000382:microbiology; D010438:Peptic Ulcer Hemorrhage / Q000139:chemically induced / Q000517:prevention & control; D010439:Peptic Ulcer Perforation / Q000139:chemically induced / Q000517:prevention & control; D054328:Proton Pump Inhibitors; D018570:Risk Assessment; D012307:Risk Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D054328:Proton Pump Inhibitors; D001241:Aspirin