Impact of pretransplantation transarterial chemoembolization on survival and recurrence after liver transplantation for hepatocellular carcinoma.
The actual impact of transarterial chemoembolization before liver transplantation (LT) for hepatocellular carcinoma (HCC) on patient survival and HCC recurrence is not known. Between 1985 and 1998, 479 patients with HCC in 14 French centers were evaluated for LT. Among these 479 patients, this case-control study included 100 patients who received transarterial chemoembolization before LT (TACE group) and 100 control patients who did not receive chemoembolization (no-TACE group). Patients and controls were matched for the pre-LT tumor characteristics, the period of transplantation, the time spent on the waiting list, and pre- and posttransplantation treatments. Kaplan-Meier estimates were calculated 5 years after LT and were compared with the log-rank test. The mean waiting time before LT was 4.2 +/- 3.2 months in the TACE group and 4.3 +/- 4.4 months in the no-TACE group. The median number of TACE procedures was 1 (range: 1-12). Demographic data, median alpha-fetoprotein level (21.6 ng/mL and 22.0 ng/mL, respectively), and pre- and post-LT morphologic characteristics of the tumors did not differ in the TACE and no-TACE groups. Overall 5-year survival was 59.4% with TACE and 59.3% without TACE (ns). Survival rates did not differ significantly between the two groups with respect to the time on the waiting list, the tumor diameter, or the type of TACE (selective or nonselective). In the TACE group, 30 patients had tumor necrosis > or =80% on the liver explant with a 5-year survival rate of 63.2%, compared with 54.2% among their matched controls (P = 0.9). In conclusion, with a mean waiting period of 4.2 months and 1 TACE procedure, pre-LT TACE does not influence post-LT overall survival and disease-free survival.
Service d'Hépatologie et de Gastroentérologie, AP-HP, Hôpital Henri Mondor, Créteil, France.|Institut Cochin, Inserm U567, Paris, France.
Thomas
T
Decaens
Département de Santé Publique, AP-HP, Hôpital Henri Mondor, Créteil, France.
Françoise
F
Roudot-Thoraval
Service d'Hépatologie, Hôpital Jean Minjoz, Besançon, France.
Solange
S
Bresson-Hadni
Service de Transplantation, Hôpital Hautefeuille, Strasbourg, France.
Carole
C
Meyer
Service de Chirurgie Digestive, Hôpital L'Archet 2, Nice, France.
Jean
J
Gugenheim
Service d'Hépatologie, AP-HP, Hôpital Beaujon, Clichy, France.
Francois
F
Durand
Service d'Hépatologie et de Gastroentérologie, Hôpital Pellegrin, Bordeaux, France.
Pierre-Henri
PH
Bernard
Service de Chirurgie Digestive, Hôpital Edouard Herriot, Lyon, France.
Olivier
O
Boillot
Département de Chirurgie Viscérale, Hôpital Ponchaillou, Rennes, France.
Karim
K
Boudjema
Service de Chirurgie Digestive, AP-HP, Hôpital Cochin, Paris, France.
Yvon
Y
Calmus
Service de Chirurgie Digestive, Hôpital la Conception, Marseille, France.
Jean
J
Hardwigsen
Service de Chirurgie Digestive, Hôpital de la Croix Rousse, Lyon, France.
Christian
C
Ducerf
Fédération Médico-Chirurgicale des Maladies de l'Appareil Digestif, Hôpital Saint-Eloi, Montpellier, France.
Georges Philippe
GP
Pageaux
Service d'Hépatologie et de Gastroentérologie, Hôpital Claude Huriez, Lille, France.
Sebastien
S
Dharancy
Service d'Hépatologie, AP-HP, Hôpital St Antoine, Paris, France.
Olivier
O
Chazouilleres
Service d'Hépatologie et de Gastroentérologie, AP-HP, Hôpital Henri Mondor, Créteil, France.
Daniel
D
Dhumeaux
Service de Chirurgie Générale et Digestive, AP-HP, Hopital Henri Mondor, Créteil, France.
Daniel
D
Cherqui
Service d'Hépatologie et de Gastroentérologie, AP-HP, Hôpital Henri Mondor, Créteil, France.|Inserm U581, Créteil, France.
Christophe
C
Duvoux
D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000628:therapy*; D016022:Case-Control Studies; D016461:Chemoembolization, Therapeutic; D016208:Databases, Factual; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000628:therapy*; D016031:Liver Transplantation / Q000379:methods / Q000401:mortality; D009336:Necrosis; D009367:Neoplasm Staging; D011300:Preoperative Care; D016019:Survival Analysis; D013997:Time Factors; D014850:Waiting Lists