Prevalence and partial sequence analysis of human T cell lymphotropic virus type I in China.
A total of 145,293 serum samples were collected from volunteer blood donors in 13 provinces of China and tested for anti-HTLV antibody using an ELISA licensed in China. Thirty were positive for anti-HTLV by ELISA and 19 of those 30 samples were confirmed positive using a supplemental immunoblot assay. Anti-HTLV-I was detected only in samples from Fujian province (a Southern province) where the positivity rate was approximately 0.05%. The region encoding gp46 from 5 of the 19 antibody positive samples was amplified and sequenced. Sequence analysis indicated that these isolates belong to HTLV-I genotype A. These data suggest that HTLV-I is not endemic throughout China and the virus may be restricted to a particular region.
Department of Cell Biology, National Institute for the Control of Pharmaceutical and Biological Products, Beijing, China.
Youchun
Y
Wang
Xiouhua
X
Li
Aijing
A
Song
Chuntao
C
Zhang
Ying
Y
Chen
Changrong
C
Chen
Yisheng
Y
Lin
Liping
L
Shun
Luilan
L
Li
Yanchun
Y
Liu
Jian
J
Yang
Bowei
B
Yang
Qiouping
Q
Tang
Tim J
TJ
Harrison
D000914:Antibodies, Viral / Q000097:blood; D002681:China / Q000453:epidemiology; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D004797:Enzyme-Linked Immunosorbent Assay; D015686:Gene Products, env / Q000235:genetics; D005838:Genotype; D015490:HTLV-I Infections / Q000453:epidemiology* / Q000821:virology*; D015368:Human T-lymphotropic virus 1 / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D015151:Immunoblotting; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D015995:Prevalence; D015682:Retroviridae Proteins, Oncogenic / Q000235:genetics; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D054299:env Gene Products, Human Immunodeficiency Virus
D000914:Antibodies, Viral; D004279:DNA, Viral; D015686:Gene Products, env; D015682:Retroviridae Proteins, Oncogenic; D054299:env Gene Products, Human Immunodeficiency Virus; C069568:gp46 protein, Human immunodeficiency virus 2