First osmium-catalysed ketamination of alkenes.
Conditions for a first oxidative conversion of alkenes into 2-amino ketones are described, which yield racemic products within a direct oxidation pathway and 2-amino ketones with up to 99% enantiomeric excess from the corresponding enantiopure amino alcohols.
Villar
Amparo
A
Kekulé-Institut für Organische Chemie und Biochemie, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany.
Hövelmann
Claas H
CH
Nieger
Martin
M
Muñiz
Kilian
K
D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry*; D000586:Amination; D002384:Catalysis; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D017892:Osmium Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D000475:Alkenes; D017892:Osmium Compounds