Depression is associated with impairment of ADL, not motor function in Parkinson disease.
Depression was diagnosed in 15% of 100 consecutive patients with Parkinson disease (PD). Depression was associated with lower cognition, history of depression, and a higher Unified Parkinson's Disease Rating Scale score. The latter was due to differences in the activities of daily living (ADL) subscale (17 +/- 7 vs 12 +/- 6; p = 0.004) rather than the motor subscale (30 +/- 13 vs 26 +/- 13; p = 0.27). These results suggest that ADL impairment may in part be due to depression. Patients with PD with poor function should be closely evaluated for depression.
Holroyd
Suzanne
S
Department of Psychiatric Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA. sh4s@virginia.edu
Currie
Lillian J
LJ
Wooten
G Frederick
GF
D000203:Activities of Daily Living / Q000523:psychology*; D000368:Aged; D003072:Cognition Disorders / Q000503:physiopathology / Q000523:psychology; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003866:Depressive Disorder / Q000453:epidemiology / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000453:epidemiology / Q000503:physiopathology / Q000523:psychology*; D015995:Prevalence