New prenylated benzoic acid derivatives of Piper hispidum.
Three new 4-hydroxy-benzoic acid derivatives, 4-methoxy-3,5-bis-(3-hydroxy-3-methyl-1-butenyl)benzoate, 3-hydroxy-2-(1-hydroxy-1-methylethyl)-2,3-dihydrobenzofuran-5-carboxylic acid, and 3-hydroxy-2-(1-hydroxy-1-methylethyl)-2,3-dihydrobenzofuran-5-carboxylic acid methyl ester together with eight known compounds, have been isolated from the stems of Piper hispidum. Their structures were elucidated by a detailed spectroscopic analysis. In addition, the cytotoxicity of seven isolated compounds has been evaluated, revealing a moderate activity for three derivatives of dillapiole.
Institut für Pharmazie (Pharmazeutische Biologie), Freie Universität Berlin, Berlin.
U
U
Friedrich
K
K
Siems
P N
PN
Solis
M P
MP
Gupta
K
K
Jenett-Siems
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology; D001565:Benzoates / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D006801:Humans; D007843:Latin America; D009682:Magnetic Resonance Spectroscopy; D031701:Piper / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D017368:Protein Prenylation
D000972:Antineoplastic Agents, Phytogenic; D001565:Benzoates; D010936:Plant Extracts