Dynamic characteristics of transient responses.
Transient responses of signaling molecules are seen in a wide variety of cellular processes that are mediated by distinct molecular mechanisms. Although transient responses might intuitively be thought to depend on the absolute concentration of growth factors or the intensity of stimulation, we here introduce that some transient responses are prompted by temporal rate of increase of stimulation, rather than intensity of stimulation, by three independent mechanisms. These include the Ras system with fast activation and slow inactivation, the ERK-dependent negative feedback loop system, and the receptor degradation system, all of which can be commonly seen in various signaling networks. In addition, we show the distinct transient and steady state characteristics of these systems.
Undergraduate Program for Bioinformatics and Systems Biology, Graduate School of Information Science and Technology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Yu-ichi
Y
Ozaki
Satoru
S
Sasagawa
Shinya
S
Kuroda
D000818:Animals; D003198:Computer Simulation; D004789:Enzyme Activation; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D007700:Kinetics; D008954:Models, Biological; D016716:PC12 Cells; D051381:Rats; D015398:Signal Transduction; D018631:ras Proteins / Q000378:metabolism
D048049:Extracellular Signal-Regulated MAP Kinases; D018631:ras Proteins