Septins: traffic control at the cytokinesis intersection.
The physical division of one cell into two requires the highly orchestrated separation of genetic and cytoplasmic contents during M phase of the cell cycle. Mitosis, the physical segregation of the genetic material of a cell into two daughter cells, has traditionally received more attention than cytokinesis, the partitioning of the cytoplasmic contents, yet clearly the two processes must be intimately co-ordinated and tightly regulated. While plant cells divide by the formation of a membranous cell barrier called the phragmoplast, animal cell division is largely driven by contraction of an actomyosin ring. However, recent evidence has suggested that membranes derived from one or more intracellular compartments are also required to break the cytoplasmic bridge connecting two dividing cells during late telophase. In this review, we focus on studies of animal cell cytokinesis that support a requirement for specific endomembrane fusion during fission, define molecular components of the membrane fusion apparatus that may be involved and point to possible roles for an emerging family of cytoskeletal proteins, the septins, in this process.
Joo
Emily
E
Program in Cell Biology, Department of Biochemistry, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada.
Tsang
Christopher W
CW
Trimble
William S
WS
D000818:Animals; D048749:Cytokinesis / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D020558:GTP Phosphohydrolases / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism*; D008561:Membrane Fusion / Q000502:physiology; D021381:Protein Transport; D050600:SNARE Proteins; D058112:Septins; D033921:Vesicular Transport Proteins / Q000378:metabolism*
D003598:Cytoskeletal Proteins; D050600:SNARE Proteins; D033921:Vesicular Transport Proteins; D020558:GTP Phosphohydrolases; C474315:SEPTIN9 protein, human; C106863:Sept2 protein, mouse; D058112:Septins