Profile of gene expression in a murine model of allergic bronchopulmonary aspergillosis.
Allergic bronchopulmonary aspergillosis (ABPA) results from the interactions of the Aspergillus allergens and immune system of the patients. We studied the gene expression profile in a mouse model of ABPA. Of the 12,000 genes studied, 1,300 genes showed enhanced expression and represent chemokine, cytokine, growth factor, signal transduction, and transmembrane receptor genes as well as genes related to arginine metabolism.
Allergy-Immunolgy Division, Medical College of Wisconsin, and Research Service 151-I, VA Medical Center, 5000 West National Avenue, Milwaukee, Wisconsin 53295, USA. vkurup@mcw.edu
Viswanath P
VP
Kurup
Raghavan
R
Raju
Pachiappan
P
Manickam
D000818:Animals; D001120:Arginine / Q000378:metabolism; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000378:metabolism*; D018925:Chemokines / Q000235:genetics; D016207:Cytokines / Q000235:genetics; D004195:Disease Models, Animal; D020869:Gene Expression Profiling; D008562:Membrane Glycoproteins / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C; D011956:Receptors, Cell Surface / Q000235:genetics; D015398:Signal Transduction; D051193:Toll-Like Receptors
D018925:Chemokines; D016207:Cytokines; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors; D001120:Arginine