[Inhibition of abdominal abscess formation in rat: mortality by sepsis].
BACKGROUND
Intra-abdominal abscesses and adhesions play important roles on isolation of a septic process and on organism protection against bacteremia. On the other hand, such phenomenon difficults the afflux of immune factors and antibiotics to the septic site. The purpose of the present study was to evaluate the effect of abscess inhibition on survival of abdominal sepsis.


METHODS
Thirty adult Wistar rats were submitted to intraperitoneal injection of 50% rat feces solution. The animals were divided into three groups (n = 10). Group 1: control - feces solution; group 2: feces solution plus 0.9% saline solution; and group 3: feces solution plus 1% carboxymethylcellulose to inhibit abdominal adhesions. The three groups were divided into two subgroups (n = 5). Subgroup A: relaparorotomy after 4 days and investigation of the abdominal cavity; and subgroup B: follow-up during 30 days to evaluate the mortality and its cause. The Fisher test was utilized for statistical analyses.


RESULTS
The injection of 0.9% saline solution did not increase the mortality of the rats. However, the mortality enhanced in the group that received carboxymethylcellulose comparing with control group. That group developed less adhesions and abscesses.


CONCLUSIONS
This study demonstrated that the reduction of abscess formation and of intraperitoneal adhesions increases the mortality due to abdominal septic disease.
Rodrigues
Fernando Henrique Oliveira Carmo
FH
Hospital Alberto Cavalcanti.
Carneiro
Bruno Gustavo Muzzi Carvalho E
BG
Rocha
Renata Figueiredo
RF
Petroianu
Andy
A
D018784:Abdominal Abscess / Q000209:etiology / Q000517:prevention & control*; D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000627:therapeutic use; D004195:Disease Models, Animal; D008297:Male; D010538:Peritonitis / Q000150:complications*; D051381:Rats; D017208:Rats, Wistar; D018805:Sepsis / Q000401:mortality*; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control
D002266:Carboxymethylcellulose Sodium