[Pharmacologic intervention for vascular calcification].
In patients with chronic renal insufficiency and dialysis, phosphate retention is a major factor in the development of vascular calcification. Prevention of phosphate retention with dietary and pharmacological means may prevent vascular calcification. Current therapy for hyperphosphatemia includes the administration of phosphate binders such as calcium carbonate (or calcium acetate), ammonium-based compounds, and phosphate-binding polymers (Renagel; sevelamer hydrochloride). However, it is difficult to administrate present phosphate binders to patients because of hypocalcaemia, outright toxicity, and constipation as its side effect. It is needed to development new drugs having fewer side effects and better compliance.
Segawa
Hiroko
H
Department of Molecular Nutrition Institution of Health Biosciences, The University of Tokushima Graduate School.
Furutani
Junya
J
Miyamoto
Ken-ichi
K
D002114:Calcinosis / Q000188:drug therapy*; D004852:Epoxy Compounds / Q000627:therapeutic use*; D006801:Humans; D010710:Phosphates / Q000097:blood; D011073:Polyamines; D011095:Polyethylenes / Q000627:therapeutic use*; D000069603:Sevelamer; D014652:Vascular Diseases / Q000188:drug therapy*
D004852:Epoxy Compounds; D010710:Phosphates; D011073:Polyamines; D011095:Polyethylenes; D000069603:Sevelamer