Fluorescent profiling of natural product producers.
The identification of natural product producer organisms remains a problem for both isolation and natural product classification. A concise screen is developed through fluorescent modification of a set of natural products that offer a common activity. Through real-time multicolor microscopy, the processing, storage, and effects of a natural product are rapidly screened at the level of the strain and individual organism.
Sandler
Joel S
JS
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093-0204, USA.
Fenical
William
W
Gulledge
Brian M
BM
Chamberlin
A Richard
AR
La Clair
James J
JJ
D000818:Animals; D001688:Biological Products / Q000032:analysis* / Q000096:biosynthesis; D001709:Biotechnology / Q000379:methods*; D004141:Dinoflagellida / Q000378:metabolism / Q000648:ultrastructure; D005456:Fluorescent Dyes / Q000138:chemical synthesis; D012680:Sensitivity and Specificity
D001688:Biological Products; D005456:Fluorescent Dyes