Thermoresponsive polymers as promising new materials for local radiotherapy.
We describe a novel thermoresponsive polymeric drug delivery system based on poly(N-isopropylacrylamide) with isotopically labellable end groups [l-tyrosinamide or diethylenetriaminepentaacetic acid (DTPA)] designed for local radiotherapy. The polymers are readily soluble in isotonic aqueous sodium chloride at room temperature and the phase separation is complete at body temperature as proved by DSC measurements. Sufficent binding capacity for radionuclides and chemical stability are demonstrated on 125I and 90Y-labelled polymers.
Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovského Sq. 2, 162 06 Prague 6, Czech Republic. mhruby@centrum.cz
M
M
Hrubý
V
V
Subr
J
J
Kucka
J
J
Kozempel
O
O
Lebeda
A
A
Sikora
D000180:Acrylic Resins / Q000737:chemistry*; D001831:Body Temperature; D002152:Calorimetry, Differential Scanning; D004369:Pentetic Acid / Q000737:chemistry; D011878:Radiotherapy / Q000295:instrumentation*
D000180:Acrylic Resins; C052970:poly-N-isopropylacrylamide; D004369:Pentetic Acid