[Pharmacogenetics of inflammatory bowel disease].
There are interindividual variations with regard to efficacy and toxicity of many commonly employed drugs. Major causes of interindividual differences of drug effects include genetic variations of drug-metabolizing enzymes, transporters and targets. Pharmacogenetics studies the genetic background of the interindividual variations of drug response. By means of preliminary genetic screening personalized treatment can be achieved, drugs with low efficacy and many side-effects can be avoided. The pharmacogenetically best studied medications of inflammatory bowel disease are azathioprine/6-mercaptopurine. It is obvious that there is a genetic background of the efficacy and toxicity of corticosteroids, 5-ASA drugs, infliximab and other immunosuppressors as well, but further studies now require to confirm the functional significance of it. Therefore, at present, the application and clinical usefulness of pharmacogenetics in the management of inflammatory bowel disease is limited. The aims of future investigations are understanding of the mechanism of drug action, identification of new drug targets and acquainting with genetic factors that determine drug response.
Semmelweis Egyetem, Altalános Orvostudományi Kar, II. Belgyógyászati Klinika, Budapest. hkriszti@bel2.sote.hu
Hagymási Krisztina
Zsolt
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Tulassay
D000636:Aminosalicylic Acids / Q000378:metabolism; D000818:Animals; D000911:Antibodies, Monoclonal / Q000378:metabolism; D001379:Azathioprine / Q000378:metabolism; D005938:Glucocorticoids / Q000378:metabolism; D006801:Humans; D007166:Immunosuppressive Agents / Q000378:metabolism* / Q000493:pharmacokinetics; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism*; D000069285:Infliximab; D015122:Mercaptopurine / Q000378:metabolism; D012460:Sulfasalazine / Q000378:metabolism
D000636:Aminosalicylic Acids; D000911:Antibodies, Monoclonal; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D012460:Sulfasalazine; D000069285:Infliximab; D015122:Mercaptopurine; D001379:Azathioprine