Repeated irradiations with gamma-rays at a Dose of 0.5 Gy may exacerbate asthma.
We previously showed that 0.5 Gy whole-body gamma-ray irradiation with a single or small number of repeated exposures inhibits tumor growth in mice, via elevation of the IFN-gamma/IL-4 ratio concomitantly with a decrease in the percentage of B cells. Here we examined whether repeated 0.5 Gy gamma-rays irradiation can improve asthma in an OVA-induced asthmatic mouse model. We found that repeated irradiation (10 times) with 0.5 Gy of gamma-rays significantly increased total IgE in comparison with the disease-control group. The levels of IL-4 and IL-5 were also significantly higher in the gamma-ray-irradiated group, while that of IFN-gamma was significantly lower, resulting in a further decrease of the IFN-gamma/IL-4 ratio from the normal value. These results indicate that the repeated irradiation with gamma-rays may exacerbate asthma, and may have opposite effects on different immune reactions unlike the irradiation with a single or small number of repeated exposures.
Department of Radiation Biosciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
Su-ping
SP
Fang
Fumitoshi
F
Tago
Takashi
T
Tanaka
Noriko
N
Simura
Yasuko
Y
Muto
Resuke
R
Goto
Shuji
S
Kojima
D000818:Animals; D001249:Asthma / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology*; D016207:Cytokines / Q000276:immunology*; D004195:Disease Models, Animal; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays / Q000009:adverse effects*; D007073:Immunoglobulin E / Q000276:immunology*; D008214:Lymphocytes / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000209:etiology* / Q000276:immunology*; D012720:Severity of Illness Index
D016207:Cytokines; D007073:Immunoglobulin E