Structural characterization of self-assembled monolayers of neoglycoconjugates using atomic force microscopy.
Thiolated self-assembled monolayers of carbohydrates may serve as useful polyvalent tools to mimic the organized presentation of such molecules at the cell surface. SAMs presenting the disaccharide maltose as a neoglycoconjugate were produced, and the structure was studied by high resolution atomic force microscopy. The molecules form highly ordered structures on a gold (111) surface, with lattice parameters determined by the linker moiety rather than the headgroup.
Laboratoire de Métallurgie Physique, SP2MI, Bld Marie et Pierre Curie, BP 30179, 86962 Futuroscope Cedex, France. christophe.tromas@univ-poitiers.fr
Christophe
C
Tromas
Peter
P
Eaton
Jean
J
Mimault
Javier
J
Rojo
Soledad
S
Penadés