Interactive effect of an acute bout of resistance exercise and dehydroepiandrosterone administration on glucose tolerance and serum lipids in middle-aged women.
The present study determined the interactive effect of an acute bout of resistance exercise and dehydroepiandrosterone (DHEA) administration on glucose tolerance and serum lipids. Twenty middle-aged female subjects performed an acute bout of resistance exercise and were subsequently divided into two groups: placebo (age 40.7 +/- 2.0) and DHEA administered (age 39.0 +/- 2.7). Ten subjects who received DHEA (age 41.5 +/- 4.6) participated in a non-exercise control. DHEA (25 mg twice daily) or placebo was orally supplemented for 48 hours. Before exercise and 48 hours after the last exercise bout (14 hours after the last DHEA intake), an oral glucose tolerance test and an insulin concentration were determined. Levels of fasting serum cholesterol and triglyceride, tumor necrosis factor-alpha (TNF-alpha), creatine kinase (CK) were also measured. The DHEA administration significantly elevated the fasting dehydroepiandrosterone sulfate (DHEA-S) level by approximately 3-fold. Both acute resistance exercise and DHEA administration improved glucose tolerance, but no addictive effect was found. Furthermore, exercise and DHEA administration did not affect serum triglyceride and cholesterol levels, but both lipids were significantly lowered when DHEA was given following exercise. Resistance exercise induced elevations in serum CK and TNFalpha levels, but these increases were attenuated by the DHEA administration. The new finding of this study was that post-exercise DHEA administration decreased serum triglycerides and cholesterol. This effect appeared to be associated with its TNF-alpha lowering action.
Yang
Sun-Chin
SC
Department of Sport Health and Leisure, Vanung University, Taipei, Taiwan, R.O.C.
Chen
Chung-Yu
CY
Liao
Yi-Hung
YH
Lin
Fang-Ching
FC
Lee
Wen-Chih
WC
Cho
Yu-Min
YM
Chen
Mu-Tsung
MT
Chous
Chia-Hau
CH
Kuo
Chia-Hua
CH
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D003402:Creatine Kinase / Q000097:blood; D003687:Dehydroepiandrosterone / Q000494:pharmacology*; D015444:Exercise; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D014409:Tumor Necrosis Factor-alpha; D003687:Dehydroepiandrosterone; D003402:Creatine Kinase