Stereoselective gamma-lactam synthesis via palladium-catalysed intramolecular allylation.
A novel route to the synthesis of 3-(tolylsulfonyl)-4,5-cis-disubstituted gamma-lactams using a diastereoselective palladium-catalysed intramolecular allylation of amino acid-derived allylic carbonates has been developed.
Craig
Donald
D
Department of Chemistry, Imperial College London, South Kensington Campus, London, UK SW7 2AZ. d.craig@imperial.ac.uk
Hyland
Christopher J T
CJ
Ward
Simon E
SE
D000498:Allyl Compounds / Q000737:chemistry*; D002384:Catalysis; D007769:Lactams / Q000138:chemical synthesis*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
D000498:Allyl Compounds; D007769:Lactams; D010165:Palladium