Extracellular HIV Tat and Tat cysteine rich peptide increase CCR5 expression in monocytes.
In our previous work we reported that HIV Tat and 6 cysteine rich peptides of Tat induce tumor necrosis factor-related apoptosis-induced ligand (TRAIL) in human monocytes (Yang et al., 2003). Here our results showed that HIV Tat and Tat cysteine rich peptide increase CCR5 expression in human monocytes, and this activity is inhibited by rabbit anti-Tat. Boiled Tat does not increase CCR5 expression in monocytes. These results provide insight into a new mechanism by which HIV Tat plays a key role in the pathogenesis of HIV-1 infection.
Zheng
Lin
L
Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Yang
Yi-da
YD
Lu
Guo-cai
GC
Salvato
Maria S
MS
D000595:Amino Acid Sequence; D002478:Cells, Cultured; D003545:Cysteine / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D045604:Extracellular Fluid / Q000737:chemistry; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D015696:Gene Products, tat / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008969:Molecular Sequence Data; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism*; D010455:Peptides / Q000737:chemistry
D015696:Gene Products, tat; D010455:Peptides; D003545:Cysteine