Chemical composition of the volatile oil from Cynanchum stauntonii and its activities of anti-influenza virus.
The volatile oil of the roots of Cynanchum stauntonii was examined by gas chromatography-mass spectrometry (GC-MS). Thirty-eight constituents were identified. (E,E)-2,4-Decadienal, 3-efhyl-4-methypentanol, 5-pentyl-3H-furan-2-one, (E,Z)-2,4-decadienal and 2(3H)-furanone,dihydro-5-pentyl were found to be the major components. The volatile oil exhibited the activities against influenza virus in vitro (IC50s=64 microg/ml). In in vivo experiment, it prevented influenza virus-induced deaths in a dose-dependent manner.
Key Laboratory of Biomechanics & Tissue Engineering (Chongqing University), Ministry of Education Bioengineering College of Chongqing University, Chongqing 400044, PR China.
Yang
Y
Zai-Chang
Wang
W
Bo-Chu
Yang
Y
Xiao-Sheng
Wang
W
Qiang
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D031105:Cynanchum / Q000737:chemistry*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D008401:Gas Chromatography-Mass Spectrometry; D009980:Influenza A virus; D008297:Male; D051379:Mice; D009975:Orthomyxoviridae / Q000187:drug effects*; D009976:Orthomyxoviridae Infections / Q000188:drug therapy; D010938:Plant Oils / Q000737:chemistry* / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D010948:Viral Plaque Assay
D000998:Antiviral Agents; D010938:Plant Oils