Design and synthesis of protein superfamily-targeted chemical libraries for lead identification and optimization.
This review chronicles original literature dating back to 1992 outlining the applications of parallel synthesis and combinatorial chemistry to the synthesis of compound libraries focused towards specific superfamilies of molecular targets. Target families that have received significant literature coverage include kinases, proteases, nuclear hormone receptors and cell surface receptors, notably GPCRs.
Department of Chemistry, Tularik Inc., 1120 Veterans Boulevard, South San Francisco, CA 94404, USA. Stephen.Shuttleworth@piramed.com
Stephen J
SJ
Shuttleworth
Richard V
RV
Connors
Jiasheng
J
Fu
Jinqian
J
Liu
Mike E
ME
Lizarzaburu
Wei
W
Qiu
Rajiv
R
Sharma
Malgorzata
M
Wãnska
Alex J
AJ
Zhang
D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D011494:Protein Kinases / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000037:antagonists & inhibitors / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors / Q000378:metabolism*
D004791:Enzyme Inhibitors; D018160:Receptors, Cytoplasmic and Nuclear; D043562:Receptors, G-Protein-Coupled; D011494:Protein Kinases