[Expression of the neopterin in serum and urine of the patients with non-Hodgkin's lymphoma].
To explore the relationship between the experimental parameters including the neopterin (Npt), LDH and beta(2)-MG concentrations in serum or urine and the therapeutic effect on non-Hodgkin's lymphoma (NHL). Npt, LDH and beta(2)-MG levels in serum and urine collected from 27 patients with NHL before and after chemotherapy were measured by ELISA, biochemistry analyzer and RIA. The relationship between the concentrations of the Npt, LDH, beta(2)-MG in serum or urine and the therapeutic effect of follow-up of NHL cases were analysed. The results indicated that the levels of serum and urine Npt and serum LDH, beta(2)-MG concentrations of pre- and post-chemotherapy in CR and PR patients were lower than that in NC and PD patients (P < 0.05). In conclusion, Npt levels of serum and urine and serum LDH, beta(2)-MG before chemotherapy can be used as prediction parameters of the therapeutic effect on NHL and the assay for Npt from the urine is more convenient than that from the serum.
Cheng
Xiao-Cheng
XC
Department of Hematology, Suzhou Hospital, Nanjing Medical University, Suzhou 215001, China. chxch2003@yahoo.com.cn
Li
Han-Chong
HC
Zhang
Ri
R
Tan
Jie
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood / Q000652:urine; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000652:urine; D008228:Lymphoma, Non-Hodgkin / Q000097:blood* / Q000188:drug therapy / Q000652:urine*; D008297:Male; D008875:Middle Aged; D019798:Neopterin / Q000097:blood* / Q000652:urine*; D001613:beta 2-Microglobulin / Q000097:blood / Q000652:urine
D015415:Biomarkers; D001613:beta 2-Microglobulin; D019798:Neopterin; D007770:L-Lactate Dehydrogenase