Sympathetically induced renal vasoconstriction during stimulation of mesencephalic locomotor region in rats.
Central command, which is a neural drive originating in the brain during exercise, regulates the sympathetic nervous system and evokes cardiovascular responses to exercise. To examine the role of the central command on sympathetic regulation of renal circulation, we compared responses in renal cortical blood flow and vascular conductance to electrical stimulation of mesencephalic locomotor region (MLR) for 30 s in decerebrate and paralyzed rats between renal nerves that were intact (n=8) and denervated (n=8). In rats with renal nerves intact, stimulation of the MLR at 40 microA current intensity significantly (p<0.05) decreased renal cortical blood flow (-17+/-5%, means+/-S.E.M.) and vascular conductance (-43+/-4%) and the decrease in renal vascular conductance was dependent on current intensity (between 20 and 60 microA). In renal denervated rats, in contrast, there were no significant changes in either renal cortical blood flow or vascular conductance during stimulation at all current intensities. In a subset of rats (n=8), the response in renal sympathetic nerve activity to 30 s stimulation of the MLR was investigated. Stimulation of the MLR significantly increased renal sympathetic nerve activity (+57+/-14% at 40 microA) and the response was dependent on current intensity (between 20 and 60 microA). These data provide evidence that central command induces renal vasoconstriction by increasing sympathetic activity, depending on central command intensity.
Koba
Satoshi
S
Graduate School of Engineering Science, Osaka University, 1-3, Machikaneyama-cho, Toyonaka, Osaka, 560-8531, Japan.
Yoshida
Takayoshi
T
Hayashi
Naoyuki
N
D000320:Adrenergic Fibers / Q000502:physiology / Q000528:radiation effects; D000818:Animals; D001794:Blood Pressure / Q000528:radiation effects; D003655:Decerebrate State / Q000503:physiopathology; D004307:Dose-Response Relationship, Radiation; D004558:Electric Stimulation / Q000379:methods; D006339:Heart Rate / Q000528:radiation effects; D007668:Kidney / Q000098:blood supply*; D017078:Laser-Doppler Flowmetry / Q000379:methods; D008297:Male; D008636:Mesencephalon / Q000502:physiology* / Q000528:radiation effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012079:Renal Circulation / Q000502:physiology*; D013562:Sympathectomy; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology*