Highly stable phenanthridinium frameworks as a new class of tunable DNA binding agents with cytotoxic properties.
A new class of cytotoxic heteroaromatic cations is presented, based on the dihydro-imidazo-phenanthridinium framework (DIP), that have affinity for DNA and cytotoxicity toward cancerous cells. The DIP framework is particularly tunable due to the flexible synthetic methodology. Furthermore, the central moiety has proved to be very stable to hydrolysis and reduction compared to other phenanthridinium-based agents.
Parenty
Alexis D C
AD
Department of Chemistry, The University of Glasgow, Joseph Black Building, UK.
Smith
Louise V
LV
Guthrie
Kevin M
KM
Long
De-Liang
DL
Plumb
Jane
J
Brown
Robert
R
Cronin
Leroy
L
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004247:DNA / Q000378:metabolism*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D007364:Intercalating Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010617:Phenanthridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D007093:Imidazoles; D007364:Intercalating Agents; D010617:Phenanthridines; C014740:phenanthridinium; D004247:DNA