Enteropathogenic Escherichia coli type III effectors EspG and EspG2 disrupt the microtubule network of intestinal epithelial cells.
Enteropathogenic Escherichia coli infection of intestinal epithelial cells leads to localized depletion of the microtubule cytoskeleton, an effect that is dependent on delivery of type III translocated effector proteins EspG and Orf3 (designated EspG2) to the site of depletion. Microtubule depletion involved disruption rather than displacement of microtubules.
Institute of Child Health, University of Birmingham, Whittall St., Birmingham B4 6NH, United Kingdom.
Robert K
RK
Shaw
Katherine
K
Smollett
Jennifer
J
Cleary
Junkal
J
Garmendia
Ania
A
Straatman-Iwanowska
Gad
G
Frankel
Stuart
S
Knutton
D000199:Actins / Q000737:chemistry; D018938:Caco-2 Cells; D004926:Escherichia coli / Q000472:pathogenicity*; D029968:Escherichia coli Proteins / Q000502:physiology*; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology*; D008870:Microtubules / Q000502:physiology*; D021381:Protein Transport
D000199:Actins; D029968:Escherichia coli Proteins; C429282:EspG protein, E coli