Antimitotic and antifungal C-3/C-3''-biflavanones from Stellera chamaejasme.
Two new C-3/C-3'' biflavanones, chamaejasmenin D (1) and isochamaejasmenin B (2), were isolated from the roots of Stellera chamaejasme, together with five known biflavanones, chamaejasmenin A (3), chamaejasmenin B (4), neochamaejasmin A (5), sikokianin A (6), and chamaejasmenin C (7). Their structures were elucidated by spectroscopic methods, including 2D NMR techniques. Among these compounds, 1-3 demonstrated potent antimitotic and antifungal activity with minimum inhibitory concentration (MIC) values of 6.25, 6.25, and 3.12 microg/ml, respectively.
Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, People's Republic of China.
Guohong
G
Yang
Zhixin
Z
Liao
Zhiyong
Z
Xu
Huiping
H
Zhang
Daofeng
D
Chen
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008938:Mitosis / Q000187:drug effects*; D013057:Spectrum Analysis
D000935:Antifungal Agents; D047309:Flavones