High-throughput magnetic resonance imaging in mice for phenotyping and therapeutic evaluation.
High-throughput mouse magnetic resonance imaging (MRI) is seeing rapidly increasing demand in development of therapeutics. Recent advances including higher-field systems, new gradient and radio frequency coils and new pulse sequences, coupled with efficient animal preparation and data handling, allow high-throughput MRI under certain protocols. However, with current shifts from anatomic to functional and molecular imaging, innovative technology is required to meet new throughput demands. The first multiple mouse imaging strategies have provided a glimpse of the future state-of-the-art. However, the successful translation of standard clinical MRI technology to preclinical MRI is required to facilitate next-generation high-throughput MRI.
McConville
Patrick
P
MIR Preclinical Services, Ann Arbor, MI 48104-1067, USA.
Moody
Jonathan B
JB
Moffat
Bradford A
BA
D000818:Animals; D003287:Contrast Media; D004353:Drug Evaluation, Preclinical / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods* / Q000639:trends; D051379:Mice; D010641:Phenotype
D003287:Contrast Media