Childhood granulomatous periorificial dermatitis: lupus miliaris disseminatus faciei in children?
BACKGROUND
Childhood granulomatous periorificial dermatitis (CGPD) is a granulomatous disease characterized by monomorphous, small papular eruptions around the mouse, nose and eyes, and is thought to be closely related to perioral dermatitis. This condition has always been believed to occur more commonly in dark-skinned patients; however, recent observations have revealed CGPD to occur also in white patients.


METHODS
We report an 11-year-old Japanese boy with the characteristic features of CGPD. Although sarcoidosis and acne/granulomatous rosacea could be differentiated from CGPD, we could find no essential differences between CGPD and lupus miliaris disseminatus faciei (LMDF). The cases of LMDF in children, which were recorded in the Japanese literature, had highly similar clinicopathological features to those of CGPD. This case responded dramatically to topical tacrolimus in combination with the oral administration of minocycline.


CONCLUSIONS
The entity 'facial idiopathic granulomas with regressive evolution' is considered to include LMDF (a common adult form), CGPD (a rare childhood form) and perioral dermatitis (a peculiar form exacerbated by topical corticosteroids). Topical tacrolimus may be recommended as one of the therapies for LMDF as well as CGPD.
Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Saga University, Nabeshima 5-1-1, Saga 849-8501, Japan. misago@post.saga-med.ac.jp
N
N
Misago
J
J
Nakafusa
Y
Y
Narisawa
D000279:Administration, Cutaneous; D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D002648:Child; D019557:Dermatitis, Perioral / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D006105:Granulomatous Disease, Chronic / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008177:Lupus Vulgaris / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008911:Minocycline / Q000008:administration & dosage; D016559:Tacrolimus / Q000008:administration & dosage
D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents; D008911:Minocycline; D016559:Tacrolimus