Nutritional interventions to counteract oxidative stress in cardiac cells.
Preventing oxidative damage in the heart is subject of considerable investigation and studies developing nutritional intervention methods to attenuate or prevent the resulting pathological state of free radical damage are now emerging. In this light, a dietary intervention directed to increase the daily intake of antioxidant molecules represents a fundamental step to achieve a beneficial result. In this minireview the attention is focused on the damage induced in cultured cardiac cells by the antitumoral doxorubicin, known for its cardiotoxicity, and by hypoxia/reoxygenation that occur in a wide variety of important clinical conditions. The identification of antioxidant molecules having specific effectiveness in a particular cell type may be useful for the development of a prevention strategy specific for free radical induced-diseases related to that cell type. Although the connection between consumption of foods rich in polyphenolic compounds and the decreased risk of cardiovascular disease has been reported, the role of different antioxidant molecules contained in foods is still to be elucidated. The protective effect of the polyphenolic components of green tea in the prevention/counteraction of cell damage induced in the heart by doxorubicin or hypoxia/reoxygenation has been discussed.
Hrelia
Silvana
S
Nutrition Research Center, Department of Biochemistry G. Moruzzi, University of Bologna, Via Irnerio, 48-Bologna, Italy. hrelia@biocfarm.unibo.it
Bordoni
Alessandra
A
Angeloni
Cristina
C
Leoncini
Emanuela
E
Biagi
PierLuigi
P
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D002478:Cells, Cultured; D004317:Doxorubicin / Q000494:pharmacology; D051379:Mice; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000378:metabolism*; D009747:Nutritional Physiological Phenomena; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats
D000975:Antioxidants; D004317:Doxorubicin