[Recent advances in the comprehension of the effects of cold ischemia in kidney graft].
Cold ischemia is the best known method to preserve kidneys for transplant. However, it produces several detrimental effects. First, cellular necrosis. Secondarily, during the hypothermic period a mitochondrial injury process develops which makes the cell entering a pre-apoptotic state. This apoptosis occurs definitively in the reperfusion. Preservation solutions currently available are not perfect and are not able to avoid cold-related cell injuries. The addition of certain substances to UW solution (desferrioxamine) has shown experimentally a reduction in mitochondrial cold-related lesions. Isolated hypothermic kidney perfusion reduces initial graft dysfunction about 20% in comparison to hypothermic storage. This fact relates to important either economical as functional consequences.
Servicio de Urología, Unidad de Preservación Renal Experimental, Hosp. Univ. Gregorio Marañón, Madrid.
E
E
Lledó García
I
I
Berenguer García
D
D
Rodríguez Martínez
G
G
Pedemonte
C
C
Hernández Fernández
J F
JF
Del Cañizo López
D000241:Adenosine / Q000627:therapeutic use; D000493:Allopurinol / Q000627:therapeutic use; D003080:Cold Temperature; D005978:Glutathione / Q000627:therapeutic use; D006085:Graft Survival; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D007511:Ischemia; D007668:Kidney; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000379:methods; D009926:Organ Preservation / Q000379:methods*; D019188:Organ Preservation Solutions / Q000627:therapeutic use; D011887:Raffinose / Q000627:therapeutic use; D015427:Reperfusion Injury / Q000503:physiopathology / Q000517:prevention & control
D007328:Insulin; D019188:Organ Preservation Solutions; C055206:University of Wisconsin-lactobionate solution; D000493:Allopurinol; D005978:Glutathione; D000241:Adenosine; D011887:Raffinose