Indole alkaloids and other constituents of Rauwolfia serpentina.
From the dried roots of Rauwolfia serpentina were isolated five new indole alkaloids, N(b)-methylajmaline (1), N(b)-methylisoajmaline (2), 3-hydroxysarpagine (3), yohimbinic acid (4), isorauhimbinic acid (5), a new iridoid glucoside, 7-epiloganin (6), and a new sucrose derivative, 6'-O-(3,4,5-trimethoxybenzoyl)glomeratose A (7), together with 20 known compounds. The structures of the new compounds were determined by spectroscopic and chemical means. The inhibitory activities of the selected alkaloids on topoisomerase I and II and their cytotoxicity against the human promyelocytic leukemia (HL-60) cell lines were assessed.
Itoh
Atsuko
A
Kobe Pharmaceutical University, Higashinada-ku, Japan.
Kumashiro
Tomoko
T
Yamaguchi
Machiko
M
Nagakura
Naotaka
N
Mizushina
Yoshiyuki
Y
Nishi
Toyoyuki
T
Tanahashi
Takao
T
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011926:Rauwolfia / Q000737:chemistry*; D013785:Thailand
D000972:Antineoplastic Agents, Phytogenic; D026121:Indole Alkaloids