Libertellenones A-D: induction of cytotoxic diterpenoid biosynthesis by marine microbial competition.
The induction of biosynthesis of four new diterpenoids was observed following the addition of a marine alpha-proteobacterium to an established culture of the marine-derived fungus Libertella sp. The fungal strain and the marine bacterium, cultured alone, do not produce diterpenoid metabolites. The induced diterpenoids, libertellenones A-D, are cross-conjugated ketones of the pimarane class. The libertellenones show varying levels of cytotoxicity against the HCT-116 human adenocarcinoma cell line with libertellenone D being the most potent (IC50 = 0.76 microM).
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093-0204, USA.
Dong-Chan
DC
Oh
Paul R
PR
Jensen
Christopher A
CA
Kauffman
William
W
Fenical
D004224:Diterpenes / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008386:Marine Biology; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D014871:Water Microbiology
D004224:Diterpenes