Blastic NK-cell lymphomas (agranular CD4+CD56+ hematodermic neoplasms): a review.
Blastic natural killer (NK) cell lymphoma (also termed CD4+CD56+ hematodermic neoplasm) is a recently described entity, with the first case reported in 1994. It was suggested initially that the disease originates from NK cells. Since 1994, single cases and a few small series have been published. In this review, data from the literature and a series of 30 cases from the French and Dutch study groups on cutaneous lymphomas are discussed. The major clinical, histopathologic, and phenotypic aspects of the disease and diagnostic criteria and data suggesting a plasmacytoid dendritic cell origin for the tumor cells are provided.
Centre de Pathologie, Department of Pathology, Centre Hospitalo-Universitaire, Dijon, France.
Tony
T
Petrella
Martine
M
Bagot
Rein
R
Willemze
Marie
M
Beylot-Barry
Béatrice
B
Vergier
Michèle
M
Delaunay
Chris J L M
CJ
Meijer
Philippe
P
Courville
Pascal
P
Joly
Florent
F
Grange
Anne
A
De Muret
Laurent
L
Machet
Anne
A
Dompmartin
Jacques
J
Bosq
Anne
A
Durlach
Philippe
P
Bernard
Sophie
S
Dalac
Pierre
P
Dechelotte
Michel
M
D'Incan
Janine
J
Wechsler
Michael A
MA
Teitell
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D015704:CD4 Antigens / Q000378:metabolism*; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism / Q000473:pathology; D019002:CD56 Antigen / Q000378:metabolism*; D002648:Child; D003713:Dendritic Cells / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000378:metabolism / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000378:metabolism / Q000473:pathology; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D015704:CD4 Antigens; D019002:CD56 Antigen