Eosinophilic esophagitis in adults, an emerging cause of dysphagia. Description of 9 cases.
BACKGROUND
Eosinophilic esophagitis is a rare condition mainly affecting children, although the number of cases reported in adults is on the increase. It is characterized by intense infiltration of eosinophilic leukocytes in the esophageal mucosa, without involvement of other sections of the alimentary canal.


METHODS
Over the past year, following the performance of endoscopies and biopsies, our service identified nine patients who were diagnosed with suffering from this disorder. Each patient sought medical help for episodes of long-term, self-limited dysphagia or food impaction in the alimentary canal.


RESULTS
Endoscopy revealed esophageal stenosis in the form of simultaneous contraction rings or regular stenosis. In six cases, the manometric study showed a nonspecific motor disorder of severe intensity affecting the esophageal body, and another patient had a disorder characterized by the presence of simultaneous waves and secondary peristaltic waves in the three thirds of the organ. These disorders are presumably due to eosinophilic infiltration of the muscular layer or ganglionar cells of the esophagus, and account for symptoms in these patients. Although the etiopathogenesis of this illness is uncertain, it is clearly an immunoallergic manifestation.


CONCLUSIONS
As the number of diagnosed cases is on the increase, eosinophilic esophagitis is in adults a specific entity within the differential diagnosis of dysphagia in young males with a history of allergies. Eosiniphilic esophagitis responds in a different number of ways to therapies used. We successfully used fluticasone propionate, a synthetic corticoid applied topically, which proved to be efficient in the treatment of this illness by acting on the pathophysiological basis of the process. It does not have any adverse effects, thus offering advantages over other therapies such as systematic corticoids or endoscopic dilations.
Lucendo Villarín
A J
AJ
Service of Digestive Diseases, Hospital Universitario La Paz, Madrid, Spain. alucendo@vodafone.es
Carrión Alonso
G
G
Navarro Sánchez
M
M
Martín Chavarri
S
S
Gómez Senent
S
S
Castillo Grau
P
P
Pascual Turrión
J M
JM
González Sanz-Agero
P
P
D000293:Adolescent; D000328:Adult; D003680:Deglutition Disorders / Q000209:etiology*; D004804:Eosinophils / Q000473:pathology*; D049631:Esophageal Sphincter, Upper / Q000473:pathology / Q000503:physiopathology; D004941:Esophagitis / Q000150:complications* / Q000473:pathology; D004945:Esophagoscopy; D004947:Esophagus / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D009092:Mucous Membrane / Q000473:pathology