A twist in anti-inflammation: annexin 1 acts via the lipoxin A4 receptor.
The inflammatory response is a life-saving protective process mounted by the body to overcome pathogen infection and injury; however, in chronic inflammatory pathologies this response can become deregulated. The existence of specialized anti-inflammatory pathways/mediators that operate in the body to down-regulate inflammation have now emerged. Thus, persistence of inflammation leading to pathology could be due to malfunctioning of one or more of these counter-regulatory pathways. Here we focus on one of them, the anti-inflammatory mediator annexin 1, and provide an update on its inhibitory effects upon the leukocyte trafficking process. In particular, recent evidence that receptors of the formyl-peptide family, which includes also the lipoxin A4 receptor, could be the annexin 1 receptor(s) in the context of anti-inflammation might provide new avenues for exploiting this pathway for drug discovery.
Centre for Biochemical Pharmacology, William Harvey Research Institute, Bart's and The London, Queen Mary School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK.
F N E
FN
Gavins
P
P
Sawmynaden
B E
BE
Chatterjee
M
M
Perretti
D000818:Animals; D017305:Annexin A1 / Q000502:physiology*; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology*; D018836:Inflammation Mediators / Q000502:physiology*; D007962:Leukocytes / Q000502:physiology; D044045:Lipoxins / Q000502:physiology; D051379:Mice; D008817:Mice, Mutant Strains; D009203:Myocardial Infarction / Q000503:physiopathology; D044067:Receptors, Lipoxin / Q000502:physiology; D018000:Receptors, Peptide
D017305:Annexin A1; D018836:Inflammation Mediators; D044045:Lipoxins; D044067:Receptors, Lipoxin; D018000:Receptors, Peptide; C040527:lipoxin A4