Comparison of the effect of 99mTc-DPD and 99mTc-MDP on experimentally-induced osteoarthritis in the stifle joint of the dog.
This study was designed to evaluate the effect of 99mTechnetium-dicarboxypropane diphosphonate (99mTc-DPD) and 99mTechnetium-methylene diphosphonate (99mTc-MDP) on bone scan image quality and time in dogs with osteoarthritis. The left cranial cruciate ligament (CrCL) in ten healthy adult Beagle dogs was transected under general anesthesia. The dogs were assigned to 99mTc-DPD-injected or 99mTc-MDP-injected groups. Stifle joint scintigraphy was performed after intravenous injection of 10 mCi 99mTc-DPD or 99mTe-MDP. Scintigraphy was conducted before CrCL transection and 2, 4, 6, 8, 10 and 12 weeks after the procedure. There were no significant differences in density, sensitivity and pathological foci between the 99mTc-DPD and 99mTc-MDP groups of experimentally-transected CrCL dogs. A comparison of the images obtained with Pinhole type and low energy general purpose type collimators of the stifle joint of normal dogs and after CrCL transaction revealed no significant differences in bone radioactivity. Scintigraphs were obtained 3 h after 99mTc-MDP and 2 h after 99mTc-DPD injection. In conclusion, application of 99mTc-DPD and 99mTc-MDP in experimentally-induced osteoarthritis of the stifle joint in dogs results in similar effects on radioactive uptake ratio and image quality. 99mTc-DPD is more efficient than 99mTc-MDP in reducing the overall time of scintigraphy.
College of Veterinary Medicine, Chungbuk National University, Republic of Korea.
Jae Yeong
JY
Lee
Won Guk
WG
Lee
Joong-Hyun
JH
Kim
Seong Soo
SS
Kang
Chun Sik
CS
Bae
Sung-Soo
SS
Koong
Seok Hwa
SH
Choi
D000818:Animals; D016118:Anterior Cruciate Ligament / Q000000981:diagnostic imaging / Q000601:surgery; D004164:Diphosphonates; D004195:Disease Models, Animal; D004285:Dogs; D015609:Organotechnetium Compounds; D010003:Osteoarthritis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D011877:Radionuclide Imaging; D013264:Stifle / Q000000981:diagnostic imaging* / Q000473:pathology; D013669:Technetium Tc 99m Medronate
D004164:Diphosphonates; D015609:Organotechnetium Compounds; C033905:technetium Tc 99m 1,1-diphosphonopropane-2,3-dicarboxylic acid; D013669:Technetium Tc 99m Medronate