Mismatch responses related to temporal discrimination of somatosensory stimulation.
OBJECTIVE
To determine the existence of a pre-attentively evoked somatosensory mismatch negativity component and to investigate the use of that component in objective clinical diagnostics.


METHODS
First we determined the temporal discrimination threshold (DT) of paired stimuli in each subject, and applied two sequential electrical stimuli to the hand with paired stimulus times of (1) DT-10 ms, (2) DT-30 ms and (3) DT+50 ms. Then, we recorded ERPs using an oddball paradigm, frequent (standard) and rare (deviant). We used two stimuli, DT-30 ms and DT-10 ms, in the first experiment, and DT-30 ms and DT+50 ms, in the second experiment.


RESULTS
In each experiment, two specific components, a negative component peaking at approximately 60ms (N60) and a large positive component peaking around 100-200 ms (P150), were identified, mainly following the deviant stimulus, which were considered somatosensory mismatch components. N60 was more remarkably identified in the second experiment and P150 in the first.


CONCLUSIONS
N60 might be generated during tasks which subjects can clearly discriminate, but P150, which seems to correspond to auditory mismatch negativity, might be generated in tasks which require fine discrimination.


CONCLUSIONS
We confirmed that our new method could be used for the objective examination of temporal discrimination.
Akatsuka
Kosuke
K
Department of Integrative Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi 444-8585, Japan. akatuka@nips.ac.jp
Wasaka
Toshiaki
T
Nakata
Hiroki
H
Inui
Koji
K
Hoshiyama
Minoru
M
Kakigi
Ryusuke
R
D000328:Adult; D001927:Brain Diseases / Q000175:diagnosis; D005073:Evoked Potentials, Somatosensory; D005260:Female; D006801:Humans; D008297:Male; D012680:Sensitivity and Specificity; D013998:Time Perception