Planned, ongoing and recently completed clinical trials for atherosclerosis prevention and regression: an update.
Recent landmark studies using hydroxy-methyl-glutaryl-Co-enzyme A reductase inhibitors (HMG-CoA reductase inhibitors or statins), specifically, pravastatin and simvastatin, have led to dramatic changes in medical practice. These clinical trials have demonstrated that clinicians can impact coronary morbidity and mortality in primary (pravastatin) and secondary (pravastatin, simvastatin) prevention settings, including post-infarct patients with 'normal' cholesterol levels (pravastatin). The clinical benefit can be seen irrespective of risk factors at baseline and in women, the elderly and diabetics.
Clinical Research-CV/Metabolism, Bristol-Myers Squibb Pharmaceutical Research Institute, Box 4000, Princeton, NJ 08543, USA.
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