A cytotoxic xanthone dimer from the entomopathogenic fungus Aschersonia sp. BCC 8401.
Ascherxanthone A (1), a novel symmetrical tetrahydroxanthone dimer, was isolated from the entomopathogenic fungus Aschersonia sp. BCC 8401. The structure of 1 was elucidated by spectroscopic analysis, especially 2D-NMR. Compound 1 exhibited activity against Plasmodium falciparum K1 with an IC(50) value of 0.20 microg/mL, but it also showed cytotoxic activities against Vero cells and three tumor cell lines.
National Center for Genetic Engineering and Biotechnology (BIOTEC), Klong Luang, Pathumthani, Thailand. isaka@biotec.or.th
Masahiko
M
Isaka
Somporn
S
Palasarn
Kanokarn
K
Kocharin
Janya
J
Saenboonrueng
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002522:Chlorocebus aethiops; D004354:Drug Screening Assays, Antitumor; D006999:Hypocreales / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects; D014407:Tumor Cells, Cultured; D014709:Vero Cells; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000962:Antimalarials; D044004:Xanthones; C502715:ascherxanthone A