Attachment of periodontal ligament cells onto various antibiotics-loaded GTR membranes.
This study compared the natures of various guided tissue regeneration (GTR) membranes impregnated with amoxicillin or tetracycline. Whether the antibiotics-loaded membranes enhance the attachment of the periodontal ligament cells in the presence of oral pathogens was further analyzed. S mutans and A actinomycetemcomitans diminished the attachment of periodontal ligament cells onto the membranes as evaluated by SEM analysis. These bacterial effects on cellular attachment could be reversed using the antibiotics-loaded membranes. The information obtained in this study is valuable for the future application of antibiotics-loaded membranes during GTR therapy.
Hung
Shan-Ling
SL
Institute of Oral Biology, National Yang-Ming University, Taipei, Taiwan.
Lin
Yi-Wen
YW
Chen
Yen-Ting
YT
Ling
Li-Jane
LJ
D016976:Aggregatibacter actinomycetemcomitans / Q000502:physiology; D000658:Amoxicillin / Q000494:pharmacology; D000704:Analysis of Variance; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects*; D015169:Colony Count, Microbial; D016557:Guided Tissue Regeneration, Periodontal; D008567:Membranes, Artificial; D008826:Microbial Sensitivity Tests; D010513:Periodontal Ligament / Q000166:cytology*; D013295:Streptococcus mutans / Q000502:physiology; D013752:Tetracycline / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D008567:Membranes, Artificial; D000658:Amoxicillin; D013752:Tetracycline