p53 Activation by small molecules: application in oncology.
Vassilev
Lyubomir T
LT
Discovery Oncology, Roche Research Center, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA. lyubomir.vassilev@roche.com
D000818:Animals; D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002352:Carrier Proteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D006801:Humans; D007093:Imidazoles / Q000737:chemistry / Q000494:pharmacology; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000517:prevention & control; D010879:Piperazines / Q000737:chemistry / Q000494:pharmacology; D011485:Protein Binding; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
D016588:Anticarcinogenic Agents; D000970:Antineoplastic Agents; D002352:Carrier Proteins; D007093:Imidazoles; C415788:Mtbp protein, mouse; D010879:Piperazines; D016159:Tumor Suppressor Protein p53; C482203:nutlin 1; C482204:nutlin 2; C482205:nutlin 3