Characterization of the multiple transferable resistance repressor, MtrR, from Neisseria gonorrhoeae.
MtrR represses expression of the Neisseria gonorrhoeae mtrCDE multidrug efflux transporter genes. MtrR displays salt-dependent DNA binding, a stoichiometry of two dimers per DNA site, and, for a protein that was expected to be essentially all helical, a high percentage of random coil and possibly beta-sheet structure.
Department of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, 97239-3098, USA.
Katherine M
KM
Hoffmann
Daniel
D
Williams
William M
WM
Shafer
Richard G
RG
Brennan
D001426:Bacterial Proteins / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism; D001483:Base Sequence; D003001:Cloning, Molecular; D004269:DNA, Bacterial / Q000235:genetics / Q000378:metabolism; D024881:Drug Resistance, Bacterial / Q000235:genetics; D007700:Kinetics; D009344:Neisseria gonorrhoeae / Q000235:genetics* / Q000378:metabolism; D017433:Protein Structure, Secondary; D012097:Repressor Proteins / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism
D001426:Bacterial Proteins; D004269:DNA, Bacterial; D012097:Repressor Proteins; C087450:mtrR protein, Neisseria gonorrhoeae