Four diterpenoid inhibitors of Cdc25B phosphatase from a marine anemone.
Three new diterpenoids and one known diterpenoid have been isolated from a sea anemone of the order Actiniara, and the structures of the new compounds, actiniarins A-C (1-3) were established on the basis of extensive 1D and 2D NMR spectroscopic data interpretation. Compound 1 has a six-membered ring hemiacetal ring, and the equilibrium of this ring is discussed. All the isolates were evaluated for their inhibition of Cdc25B and for cytotoxicity against the A2780 ovarian cancer cell line.
Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Shugeng
S
Cao
Caleb
C
Foster
John S
JS
Lazo
David G I
DG
Kingston
D031883:Anemone / Q000737:chemistry*; D000818:Animals; D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors*; D004224:Diterpenes / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011817:Rabbits; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013237:Stereoisomerism; D020687:cdc25 Phosphatases / Q000037:antagonists & inhibitors*
D018797:Cell Cycle Proteins; D004224:Diterpenes; D004791:Enzyme Inhibitors; C517008:CDC25B protein, human; D020687:cdc25 Phosphatases