Eph/ephrin A- and B-family expression patterns in the leopard frog (Rana utricularia).
Eph/ephrin expression was studied in Rana utricularia larvae and adults with in situ receptor and ligand affinity probes. From stages TK-II (early limb bud) to VI (early foot paddle larva), tectal EphB expression is highest in a band extending transversely across the posterior optic tectum and grades off anteriorly and posteriorly. The ephrin-A expression gradient is parallel to the EphB gradient rather than being orthogonal to it. However, its high point occupies the posterior pole, and it runs from high-posteriorly to low-anteriorly. Tectal EphA expression is high anteriorly and low posteriorly, while ephrin-Bs are expressed only in a thin line at the dorsal midline. At later stages and in adults, tectal EphB expression becomes uniform.
Scalia
Frank
F
Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA. fscalia@downstate.edu
Feldheim
David A
DA
D000818:Animals; D019521:Body Patterning / Q000502:physiology; D002460:Cell Line; D036342:Ephrins / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D047468:Immunoprecipitation / Q000379:methods; D007814:Larva; D008024:Ligands; D051379:Mice; D011485:Protein Binding; D011894:Rana pipiens / Q000033:anatomy & histology / Q000502:physiology*; D036081:Receptors, Eph Family / Q000145:classification / Q000378:metabolism; D013477:Superior Colliculi / Q000254:growth & development / Q000378:metabolism; D014162:Transfection / Q000379:methods; D014795:Visual Pathways / Q000254:growth & development / Q000378:metabolism
D036342:Ephrins; D008024:Ligands; D036081:Receptors, Eph Family