Cationic niosomes as gene carriers: preparation and cellular uptake in vitro.
Cationic niosomes of sorbitan monoesters were prepared using film hydration method and tested for their effect on delivery of antisense oligonucleotides (OND) in a COS-7 cell line. These formulations showed positive results on cellular uptake of antisense oligonucleotides. Especially, cationic niosomes of Span 40 and 60 have a more significant effect.
Department of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, PR China.
Y Z
YZ
Huang
G
G
Han
H
H
Wang
W Q
WQ
Liang
D000818:Animals; D019556:COS Cells; D002412:Cations; D002522:Chlorocebus aethiops; D004247:DNA / Q000008:administration & dosage* / Q000378:metabolism; D004339:Drug Compounding; D004563:Electrochemistry; D004591:Electrophoresis, Polyacrylamide Gel; D005079:Excipients; D018014:Gene Transfer Techniques; D008567:Membranes, Artificial; D008863:Microspheres; D010316:Particle Size; D013778:Tetrazolium Salts; D013844:Thiazoles
D002412:Cations; D005079:Excipients; D008567:Membranes, Artificial; D013778:Tetrazolium Salts; D013844:Thiazoles; D004247:DNA; C022616:thiazolyl blue