[Toxicological analysis of selected 1,4-dihydropyridine calcium channel blockers in the diagnosis of intoxications].
This study is aimed at evaluating effective techniques of qualitative and quantitative analysis of selected 1,4-dihydropyridine calcium channel blockers, useful both for thanatological diagnosis of intoxications as well as monitoring therapy. The studies took advantage of gas chromatography (GLC) and high performance liquid chromatography (HPLC). Isolation of studied compounds from biological material was performed using classical and solid phase extraction procedures (SPE) such as Bond Elut LRC (Varian), Abselut Nexus (Varian), STRATA C - 18 E (Phenomenex). The program included analysis of nine of the most frequently prescribed derivatives: nifedipine, felodipine, amlodipine, nicardipine, nimodypine, nilvadipine, nitrendipine, nisoldipine, isradipine.
Katedra i Zakład Medycyny Sadowej, Poznán.
Roman
R
Wachowiak
Bogna
B
Strach
Paweł
P
Lopatka
D017311:Amlodipine / Q000097:blood / Q000506:poisoning; D002121:Calcium Channel Blockers / Q000097:blood* / Q000506:poisoning*; D002849:Chromatography, Gas / Q000379:methods; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004095:Dihydropyridines / Q000097:blood* / Q000506:poisoning*; D015736:Felodipine / Q000097:blood / Q000506:poisoning; D005554:Forensic Medicine / Q000379:methods; D006801:Humans; D017275:Isradipine / Q000097:blood / Q000506:poisoning; D009529:Nicardipine / Q000097:blood / Q000506:poisoning; D009543:Nifedipine / Q000031:analogs & derivatives / Q000097:blood / Q000506:poisoning; D009553:Nimodipine / Q000097:blood / Q000506:poisoning; D015737:Nisoldipine / Q000097:blood / Q000506:poisoning; D009568:Nitrendipine / Q000097:blood / Q000506:poisoning; D011044:Poland; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; C035100:nilvadipine; D017311:Amlodipine; D015737:Nisoldipine; D009553:Nimodipine; C038806:1,4-dihydropyridine; D009568:Nitrendipine; D009529:Nicardipine; D009543:Nifedipine; D015736:Felodipine; D017275:Isradipine