Pediatric giant cell glioblastoma: a case report and review of the literature.
BACKGROUND
Giant cell glioblastoma is a subtype of glioblastoma multiforme (GM) whose most characteristic histology is the presence of plentiful multinucleated giant cells. These tumours are very rare and account for only 5% of GM. They do not have specific localization, although normally they are supratentorial and affect mostly the temporal lobe. They may occur at any age, but mostly they occur in younger people than GM. They are infrequent in childhood, but they have longer survival in paediatric age.


METHODS
We present an 11-year-old girl that was operated but whose tumour recurred in a month after apparent total removal.


CONCLUSIONS
We review in the literature the clinical, histological, immuno-histochemical and genetic characteristics, as well the prognosis of this tumour.
Service of Anatomic Pathology, Hospital Infantil Universitario Niño Jesús, Avda Menedez Pelayo, Madrid, Spain. ideprada.hnjs@salud.madrid.org
I
I
De Prada
F
F
Cordobés
D
D
Azorín
T
T
Contra
I
I
Colmenero
I
I
Glez-Mediero
D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D002648:Child; D005260:Female; D005909:Glioblastoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism*; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D013702:Temporal Lobe / Q000378:metabolism / Q000473:pathology* / Q000601:surgery
D019394:Ki-67 Antigen