Synthesis of multitopic neoglycopeptides displaying recognition and detection motifs.
We describe herein the synthesis of cyclic decapeptide template displaying clustered carbohydrate recognition motifs and detection agent on spatially separated domains. Such multitopic labeled neoglycopeptides represent attractive tools for binding assays with carbohydrate binding proteins in glycomic research.
LEDSS, UMR-CNRS 5616 & ICMG FR 2607, Université Joseph Fourier, BP 53 38041 Grenoble Cedéx 9, France.
Olivier
O
Renaudet
Pascal
P
Dumy
D020816:Amino Acid Motifs; D001665:Binding Sites; D002241:Carbohydrates / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D006020:Glycopeptides / Q000138:chemical synthesis*; D008956:Models, Chemical; D010456:Peptides, Cyclic / Q000138:chemical synthesis*
D002241:Carbohydrates; D006020:Glycopeptides; D010456:Peptides, Cyclic