[Fatal intoxication with amisulpride and presentation of organ distribution].
Amisulpride is a substituted benzamide used as an atypical antipsychotic drug. It antagonizes dopamine D2 and D3 receptor-mediated effects with greater affinity for the limbic system suggesting better neurological tolerance than classical neuroleptics. However, occasionally amisulpride intoxications associated with seizures, comatose conditions and agitation, hyperthermia, tachycardia, prolongation of the QT interval and extrapyramidal features have been described. A 27-year-old female with a medical history of psychosis and amisulpride therapy was found dead at home. By means of high performance liquid chromatography coupled with mass spectrometry (LC/MS) an amisulpride concentration of 13.4 mg/l was found in the peripheral blood. A lower concentration in the brain and an extremely high concentration in bile can be explained by the polarity and hydrophobic character of the substance. After macroscopic and histological exclusion of other causes of death the results of the toxicological analysis were consistent with the assumption of a fatal amisulpride overdose.
Aus dem Institut für Rechtsmedizin der Universität Bonn.
Frank
F
Musshoff
Lars
L
Kröner
Stephan A
SA
Padosch
Burkhard
B
Madea
D000328:Adult; D000077582:Amisulpride; D014150:Antipsychotic Agents / Q000493:pharmacokinetics* / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D011618:Psychotic Disorders / Q000097:blood / Q000188:drug therapy / Q000473:pathology; D013405:Suicide / Q000331:legislation & jurisprudence*; D013469:Sulpiride / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000633:toxicity; D014018:Tissue Distribution
D014150:Antipsychotic Agents; D013469:Sulpiride; D000077582:Amisulpride