[Host risk factors for acquirement of antimicromial resistant gene in Haemophilus influenzae].
The present study investigated the host risk factors for carriage of Haemophilus influenzae (H. influenzae) with resistant gene (s) against antibiotics. From September 2001 to January 2004, 174 strains of H. influenzae were isolated from the nasopharynx of children with respiratory tract infections. We classified these strains on the basis of the MIC to Ampicillin and the presence of resistant gene (s) for antibiotics resistance (gene for beta-lactams and altered pbp gene (s)). The patients' background such as previous antibiotic usage, age, daycare attendance, siblings and underlying diseases was investigated. The risk factor for carriage of strains with altered pbp gene (s) was the usage of beta-lactams within the last 3 months. Controlled usage of oral beta-lactams might be an important issue for preventing the spread of resistant H. influenzae strains such as beta-lactamase non-producing ampicillin resistant H. influenzae. We have to reconsider a therapeutic approach for the treatment of young children with respiratory tract infection.
Department of Pediatrics, Soma General Hospital.
Ayumi
A
Matsumoto
Mitsuaki
M
Hosoya
Masahiko
M
Katayose
Kiyohiko
K
Watanabe
Kazuo
K
Kato
Hitoshi
H
Suzuki
D000668:Ampicillin Resistance / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006193:Haemophilus influenzae / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D009305:Nasopharynx / Q000382:microbiology; D012141:Respiratory Tract Infections / Q000382:microbiology*; D012307:Risk Factors; D018440:beta-Lactam Resistance / Q000235:genetics*