The correlation of paraoxonase (PON1) activity with lipid and lipoprotein levels differs with vascular disease status.
Paraoxonase (PON1) is an HDL-associated enzyme. Low PON1 activity predicts vascular disease status and is a more reliable predictor of vascular disease than are functional PON1 genotypes. There is evidence that the relationship of PON1 to vascular disease is, in part, due to its antioxidant activity. However, the physical relationship of PON1 with HDL and the existence of cholesterol pathway regulatory elements at the PON1 locus suggest a further relationship of PON1 with lipoproteins, which may contribute to its role in vascular disease. We investigated the relationship of PON1 activity and genotype to lipid-related traits in 91 Caucasian men with severe carotid artery disease and 184 without vascular disease who were not on lipid-lowering medications. Prior studies of PON1 relationship to lipids have not stratified by disease status.. We found that PON1 activity was correlated with HDL traits in controls and with LDL- and VLDL-related traits in cases. We hypothesize differences in the joint regulation of PON1 and lipoproteins in cases and controls.
Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Laura S
LS
Rozek
Thomas S
TS
Hatsukami
Rebecca J
RJ
Richter
Jane
J
Ranchalis
Karen
K
Nakayama
Laura A
LA
McKinstry
David A
DA
Gortner
Edward
E
Boyko
Gerard D
GD
Schellenberg
Clement E
CE
Furlong
Gail P
GP
Jarvik
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016632:Apolipoprotein A-I / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D043303:Aryldialkylphosphatase / Q000235:genetics / Q000378:metabolism*; D002340:Carotid Artery Diseases / Q000097:blood / Q000201:enzymology*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D053440:Lipoproteins, HDL3; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged
D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D008055:Lipids; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D053440:Lipoproteins, HDL3; D008077:Lipoproteins, LDL; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human