Genome scale identification of Treponema pallidum antigens.
Antibody responses for 882 of the 1,039 proteins in the proteome of Treponema pallidum were examined. Sera collected from infected rabbits were used to systematically identify 106 antigenic proteins, including 22 previously identified antigens and 84 novel antigens. Additionally, sera collected from rabbits throughout the course of infection demonstrated a progression in the breadth and intensity of humoral immunoreactivity against a representative panel of T. pallidum antigens.
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.
Matthew
M
McKevitt
Mary Beth
MB
Brinkman
Melanie
M
McLoughlin
Carla
C
Perez
Jerrilyn K
JK
Howell
George M
GM
Weinstock
Steven J
SJ
Norris
Timothy
T
Palzkill
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000276:immunology*; D016680:Genome, Bacterial; D020543:Proteome; D011817:Rabbits; D014210:Treponema pallidum / Q000235:genetics / Q000276:immunology*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D020543:Proteome