Discovery of new natural products by application of X-hitting, a novel algorithm for automated comparison of full UV spectra, combined with structural determination by NMR spectroscopy.
X-hitting, a newly developed algorithm for automated comparison of UV data, has been used for the tracking of two novel spiro-quinazoline metabolites, lapatins A (1) and B (2), in a screening study targeting quinazolines. The structures of 1 and 2 were elucidated by analysis of spectroscopic data, primarily 2D NMR.
Center for Microbial Biotechnology, BioCentrum-DTU, Søltofts Plads, Technical University of Denmark, Lyngby. tol@biocentrum.dtu.dk
Thomas Ostenfeld
TO
Larsen
Bent O
BO
Petersen
Jens Ø
JØ
Duus
Dan
D
Sørensen
Jens C
JC
Frisvad
Michael E
ME
Hansen
D000465:Algorithms; D001688:Biological Products / Q000737:chemistry* / Q000302:isolation & purification*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011799:Quinazolines / Q000737:chemistry* / Q000302:isolation & purification*; D012984:Software; D013056:Spectrophotometry, Ultraviolet
D001688:Biological Products; D011799:Quinazolines; C502651:lapatin A; C502652:lapatin B