[Detection of expression of endometriosis-related cytokine and their receptor genes by cDNA microarray technique].
OBJECTIVE
To study the pathogenesis of endometriosis(EM) by investigating cytokine(CK) and CKR genes expression involved in the development of EM.


METHODS
The CK and CKR gene expression pattern in samples of EM and normal endometrial tissues were analyzed by using cDNA microarrays.


RESULTS
119 genes were expressed differently between 3 cases EM tissues and 3 cases normal endometria tissues. Among them, 15 were CK and CKR genes, including IL-1, IL-2, IL-6, IL-8, VEGFR, TGF, EGF, FGF, and EPOR etc.


CONCLUSIONS
These 15 differently expressed CK and CKR genes may be correlated with the development of EM.
Department of Obstetrics and Gynecology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Yang
Y
Fan
Bi-liang
BL
Chen
Xiang-dong
XD
Ma
Ming-quan
MQ
Su
D000818:Animals; D016207:Cytokines / Q000235:genetics*; D004715:Endometriosis / Q000235:genetics* / Q000473:pathology; D004717:Endometrium / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D005260:Female; D020869:Gene Expression Profiling; D020411:Oligonucleotide Array Sequence Analysis; D012313:RNA / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism; D018121:Receptors, Cytokine / Q000235:genetics*; D012984:Software
D016207:Cytokines; D018121:Receptors, Cytokine; D012313:RNA