Effect of non-surgical periodontal treatment with or without doxycycline on the periodontium of type 1 diabetic patients.
OBJECTIVE
The present investigation was performed to study how type 1 diabetics responded to non-surgical periodontal treatment with and without adjunctive doxycycline.


METHODS
Sixty diabetic type 1 patients (mean age 35.3+/-9 years) with moderate-to-severe periodontal disease were selected and divided into two groups of 30 patients each. Both groups were sex and age matched and had similar amounts of periodontal destruction. Plaque index (PI), bleeding on probing (BOP), probing depth (PD) and clinical attachment levels (CAL) were recorded. Group 1 (30 patients) was treated with oral hygiene instruction, scaling and root planing, chlorhexidine rinses twice a day and doxycycline (100 mg/day for 15 days). Group 2 (30 patients) had the same treatment but without doxycycline. After 12 weeks their periodontal condition was reevaluated.


RESULTS
After treatment, both groups had a significant improvement in all periodontal parameters, since PI, BOP, probing pocket depth (PPD) and CAL were significantly reduced. However, the reduction in PD in pockets > or =6 mm and in BOP were more evident when doxycycline was used (group 1). Differences between groups for these parameters were statistically significant (p=0.03).


CONCLUSIONS
Although both periodontal treatment regimens are effective in type 1 diabetics, the use of doxycycline as an adjunct, provided more significant results when good plaque control was achieved.
University of Valencia, Valencia, Spain. fernandollambes@ono.com
Fernando
F
Llambés
Francisco-Javier
FJ
Silvestre
Antonio
A
Hernández-Mijares
Rami
R
Guiha
Raúl
R
Caffesse
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017742:Dental Care for Chronically Ill; D003774:Dental Plaque Index; D012534:Dental Scaling; D048909:Diabetes Complications / Q000188:drug therapy / Q000628:therapy; D003922:Diabetes Mellitus, Type 1; D004318:Doxycycline / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010510:Periodontal Diseases / Q000150:complications / Q000188:drug therapy / Q000628:therapy*; D010512:Periodontal Index; D016037:Single-Blind Method; D013997:Time Factors; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D004318:Doxycycline