Iatrogenic (para-) spinal abscesses and meningitis following injection therapy for low back pain.
Low back pain is often treated with paraspinal injections of analgesics and steroids. Infectious complications of these techniques are rare but they can potentially hold high risks for the patients. History and clinical data of all patients admitted to a neurological unit suffering from community acquired purulent meningitis were prospectively analyzed during an 8 year interval (1992 and 2000) with special regard to the previous medical history. One hundred and twenty eight patients were included in the study. Eight out of 128 patients (6.25%) had a history of single or repeated paravertebral (4/8), facet-joint (2/8), peridural (1/8) or spinal (1/8) injections 2-21 days before admission to the hospital. In six out of eight patients either Staphylococcus aureus (4/8) or coagulase-negative staphylococci (2/8) were found in the cerebro spinal fluid (CSF), in two patients no causative organism was detected. One patient died, three survived with sequel. Repeated paraspinal, peridural or spinal injections with analgesic drugs in combination with corticosteroids hold a risk for parameningeal inoculation of bacteria resulting in paraspinal, spinal, and epidural abscesses or meningitis. The absolute frequency of these complications may be rare but they are responsible for a considerable proportion of community acquired purulent CNS infections.
Klinik und Poliklinik für Neurologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany Klinik und Poliklinik für Neurologie, Martin-Luther-Universität, Germany Neurologische Klinik, Krankenhaus Rummelsberg, Germany.
C
C
Gaul
B
B
Neundörfer
M
M
Winterholler
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000700:Analgesics / Q000008:administration & dosage / Q000009:adverse effects*; D003030:Coagulase / Q000134:cerebrospinal fluid; D003710:Demography; D004333:Drug Administration Routes; D004359:Drug Therapy, Combination; D020802:Epidural Abscess / Q000139:chemically induced* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007267:Injections; D007268:Injections, Epidural; D017116:Low Back Pain / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D016920:Meningitis, Bacterial / Q000139:chemically induced* / Q000453:epidemiology; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D012306:Risk; D013256:Steroids / Q000008:administration & dosage / Q000009:adverse effects*
D000700:Analgesics; D003030:Coagulase; D013256:Steroids