Squalamine: a polyvalent drug of the future?
The purpose of this mini-review is to summarize and highlight the different advances in our understanding of the antimicrobial and antiangiogenic activity of squalamine, a cationic steroid isolated in 1993 from the dogfish shark Squalus Acanthias. Indeed, squalamine has shown to be useful for the treatment of important diseases such as cancers (lung, ovarian, brain and others), age-related macular degeneration (AMD) and the control of body weight in man. All these results led to a question: could we consider squalamine as a polyvalent drug of the future?
Laboratoire SESNAB Faculté de St Jérôme, Université Paul Cézanne, Av. Escadrille Normandie Niemen, 13397 Marseille, Cedex 20, France. bruneljm@yahoo.fr
Jean Michel
JM
Brunel
Chanaz
C
Salmi
Celine
C
Loncle
Nicolas
N
Vidal
Yves
Y
Letourneux
D000818:Animals; D002777:Cholestanols / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D004358:Drug Therapy / Q000639:trends*; D006801:Humans; D013678:Technology, Pharmaceutical / Q000639:trends
D002777:Cholestanols; C079655:squalamine