The plant lignans matairesinol and secoisolariciresinol administered to Min mice do not protect against intestinal tumor formation.
The lignans matairesinol (MAT) and secoisolariciresinol (SECO) were fed to Min mice at 0.02% (w/w) in diet to study their effects on intestinal tumor development. The mean number (67 vs. 51, P=0.052) and size (1.4 vs. 1.2 mm, P=0.011) of tumors in the MAT group was elevated when compared with the control group. Tumor formation of the SECO group did not differ from the control group. Intake of MAT increased the level of both MAT and enterolactone in the plasma while SECO feeding increased SECO, enterodiol, and enterolactone (P=0.001). These results showed that MAT or SECO do not prevent intestinal carcinogenesis in Min mice and that MAT may have adverse effects.
Pajari
Anne-Maria
AM
Department of Applied Chemistry and Microbiology, Division of Nutrition, University of Helsinki, P.O. Box 66, 00014 Helsinki, Finland.
Smeds
Annika I
AI
Oikarinen
Seija I
SI
Eklund
Patrik C
PC
Sjöholm
Rainer E
RE
Mutanen
Marja
M
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000097:blood; D025601:Adenomatous Polyposis Coli Protein / Q000235:genetics / Q000502:physiology*; D000818:Animals; D002072:Butylene Glycols / Q000008:administration & dosage*; D004032:Diet; D004195:Disease Models, Animal; D005260:Female; D005663:Furans / Q000008:administration & dosage*; D007414:Intestinal Neoplasms / Q000517:prevention & control*; D017705:Lignans / Q000008:administration & dosage* / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010944:Plants / Q000737:chemistry*
D025601:Adenomatous Polyposis Coli Protein; D002072:Butylene Glycols; D005663:Furans; D017705:Lignans; C068935:matairesinol; C060283:secoisolariciresinol; D015107:4-Butyrolactone; C029497:2,3-bis(3'-hydroxybenzyl)butyrolactone