Deep venous thrombosis in a child associated with an abnormal inferior vena cava.
Congenital anomalies of the inferior vena cava (IVC), such as absence or atresia, although well documented, are uncommon and result from aberrant development during embryogenesis. Absence or atresia of the IVC is usually discovered accidentally. Patients are typically asymptomatic of the condition itself. Many concurrent cardiovascular-associated abnormalities have been described. We report a 10-y-old boy admitted to the emergency room with painful swelling of his right lower limb without previous trauma or surgery. After 3 d, swelling also involved the left lower limb. A Doppler ultrasound of the lower limbs revealed bilateral thrombosis of the vena iliaca communis, vena iliaca externa, femoral vein communis and superficial extending to the IVC. Magnetic resonance imaging (MRI) of the abdomen was performed. On MRI, we demonstrated a hypoplastic IVC. The results of blood coagulation studies, including levels of antiphospholipid antibodies, proteins C and S, and antithrombin III, were normal. The patient was treated with intravenous heparin for 8 d and discharged with oral warfarin therapy, which has been recommended for life. Therapy against deep venous thrombosis must be focused on its prevention in the future. An abnormal inferior vena cava should be considered in young patients with deep venous thrombosis without apparent cause.
Sakellaris
G
G
Clinic of Paediatric Surgery, School of Medicine, University of Crete, Greece. gsakell@hol.gr
Tilemis
S
S
Papakonstantinou
O
O
Bitsori
M
M
Tsetis
D
D
Charissis
G
G
D000925:Anticoagulants / Q000008:administration & dosage; D002648:Child; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D018615:Ultrasonography, Doppler, Color; D014682:Vena Cava, Inferior / Q000002:abnormalities* / Q000473:pathology; D020246:Venous Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D014859:Warfarin / Q000008:administration & dosage
D000925:Anticoagulants; D014859:Warfarin