L. micdadei PVE successfully treated with levofloxacin/valve replacement: case report and review of the literature.
Prosthetic valve endocarditis (PVE) due to Legionella micdadei was diagnosed in a man a year after valve replacement with a bovine xenograft. He did not have pneumonia. The microbiologic diagnosis was established after valvectomy, which was necessitated by failure of empiric antibiotics to eradicate the infection. The fastidious organism grew only on buffered charcoal yeast extract agar and was confirmed as L. micdadei by gene sequence analysis. We believe this to be the first culture-proven case of L. micdadei PVE reported in the literature.
Patel
Mahesh C
MC
Division of Infectious Diseases, Department of Internal Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210th St, Bronx, NY 10467, USA. maheshpatel.md@gmail.com
Levi
Michael H
MH
Mahadevi
Panna
P
Nana
Michele
M
Merav
Avraham D
AD
Robbins
Noah
N
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001705:Bioprosthesis; D020878:Device Removal; D004697:Endocarditis, Bacterial / Q000188:drug therapy / Q000382:microbiology; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects; D006689:Hodgkin Disease / Q000628:therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000628:therapy; D016030:Kidney Transplantation; D007875:Legionella / Q000302:isolation & purification; D007876:Legionellosis / Q000188:drug therapy* / Q000382:microbiology; D064704:Levofloxacin; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000627:therapeutic use*; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000382:microbiology; D011832:Radiation Injuries; D012086:Reoperation; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents; D064704:Levofloxacin; D015242:Ofloxacin