Biyouyanagin A, an anti-HIV agent from Hypericum chinense L. var. salicifolium.
[structure: see text] A structurally unique hydrophobic compound, biyouyanagin A, was isolated from the MeOH extract of the leaves of Hypericum chinense L. var. salicifolium. The structure of biyouyanagin A was elucidated on the basis of spectroscopic evidence. Biyouyanagin A showed a significant activity against HIV and inhibited cytokine production.
Faculty of Pharmaceutical Sciences, University of Tokushima, Japan.
Naonobu
N
Tanaka
Mamoru
M
Okasaka
Youko
Y
Ishimaru
Yoshihisa
Y
Takaishi
Mitsunobu
M
Sato
Masato
M
Okamoto
Tetsuya
T
Oshikawa
Sharif Uddin
SU
Ahmed
L Mark
LM
Consentino
Kuo-Hsiung
KH
Lee
D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D016207:Cytokines / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D020902:Hypericum / Q000737:chemistry*; D016753:Interleukin-10 / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D018664:Interleukin-12 / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D008070:Lipopolysaccharides / Q000494:pharmacology; D015394:Molecular Structure; D018515:Plant Leaves; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013141:Spiro Compounds; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000096:biosynthesis
D019380:Anti-HIV Agents; D016207:Cytokines; D008070:Lipopolysaccharides; D012717:Sesquiterpenes; D013141:Spiro Compounds; D014409:Tumor Necrosis Factor-alpha; C509583:biyouyanagin A; D016753:Interleukin-10; D018664:Interleukin-12