Blastic NK-cell lymphomas (agranular CD4+CD56+ hematodermic neoplasms): a review.
Blastic natural killer (NK) cell lymphoma (also termed CD4+CD56+ hematodermic neoplasm) is a recently described entity, with the first case reported in 1994. It was suggested initially that the disease originates from NK cells. Since 1994, single cases and a few small series have been published. In this review, data from the literature and a series of 30 cases from the French and Dutch study groups on cutaneous lymphomas are discussed. The major clinical, histopathologic, and phenotypic aspects of the disease and diagnostic criteria and data suggesting a plasmacytoid dendritic cell origin for the tumor cells are provided.
Petrella
Tony
T
Centre de Pathologie, Department of Pathology, Centre Hospitalo-Universitaire, Dijon, France.
Bagot
Martine
M
Willemze
Rein
R
Beylot-Barry
Marie
M
Vergier
Béatrice
B
Delaunay
Michèle
M
Meijer
Chris J L M
CJ
Courville
Philippe
P
Joly
Pascal
P
Grange
Florent
F
De Muret
Anne
A
Machet
Laurent
L
Dompmartin
Anne
A
Bosq
Jacques
J
Durlach
Anne
A
Bernard
Philippe
P
Dalac
Sophie
S
Dechelotte
Pierre
P
D'Incan
Michel
M
Wechsler
Janine
J
Teitell
Michael A
MA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D015704:CD4 Antigens / Q000378:metabolism*; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism / Q000473:pathology; D019002:CD56 Antigen / Q000378:metabolism*; D002648:Child; D003713:Dendritic Cells / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000378:metabolism / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000378:metabolism / Q000473:pathology; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D015704:CD4 Antigens; D019002:CD56 Antigen