Structural diversity of streptokinase and activation of human plasminogen.
The beta domain of streptokinase is required for plasminogen activation and contains a region of sequence diversity associated with infection and disease in group A streptococci. We report that mutagenesis of this polymorphic region does not alter plasminogen activation, which suggests an alternative function for this molecular motif in streptococcal disease.
Lizano
Sergio
S
Department of Microbiology and Immunology, New York Medical College, Valhalla, New York 10595, USA. sergio_lizano@nymc.edu
Johnston
Kenneth H
KH
D000595:Amino Acid Sequence; D008969:Molecular Sequence Data; D010958:Plasminogen / Q000378:metabolism*; D013300:Streptokinase / Q000737:chemistry* / Q000502:physiology; D013329:Structure-Activity Relationship
D010958:Plasminogen; D013300:Streptokinase