Midupper arm circumference (MUAC) changes in late pregnancy predict fetal growth in twins.
The objective of the study was to test the hypothesis that changes in arm anthropometry can be used to determine the risk of faltering growth in twin gestations. Serial data on midupper arm circumference (MUAC) and maternal weight gain were collected from a sample of 156 mothers. Changes in MUAC were monitored from 20 to 34 weeks. Women with a large loss of MUAC (greater than 1.5 cm), particularly when it occurred within two to four weeks of delivery, were significantly heavier, had higher pregravid Body Mass Indexes (BMIs), but gained less weight than mothers with no change in MUAC. In analysis of covariance models adjusting for length of gestation, black ethnicity, males per twin pair, monochorionicity, and baseline MUAC at 20 weeks, a large loss of MUAC was associated with significantly lower birthweight (2263 g vs. 2499 g) and birthweight z-score (-0.92 SDU vs. -0.39 SDU). Changes in MUAC from 20 to 34 weeks, and especially near delivery, are significantly associated with fetal growth in twin pregnancies. A positive change may indicate that the mother has adequate dietary intake or nutrient stores to continue to accrue lean body mass and support fetal growth, while a loss of MUAC indicates that dietary intake or nutrient stores may be inadequate. This simple, relatively precise, measure of change in maternal body composition during pregnancy may be useful in identifying twin pregnancies at risk for faltering intrauterine growth, particularly among overweight or obese women.
Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, NIH/DHHS, Building 6100, Rm. 7B03, 9000 Rockville Pike, Bethesda, MD 20892-7510, USA. hedigerm@exchange.nih.gov
Mary L
ML
Hediger
Barbara
B
Luke
Cosmas
C
van de Ven
Clark
C
Nugent
D000328:Adult; D000704:Analysis of Variance; D001132:Arm / Q000033:anatomy & histology*; D001724:Birth Weight; D015992:Body Mass Index; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D009035:Mothers; D009752:Nutritional Status; D011237:Predictive Value of Tests; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011272:Pregnancy, Multiple / Q000502:physiology*; D012680:Sensitivity and Specificity; D014427:Twins; D015430:Weight Gain