Signaling to cytoskeletal dynamics during chemotaxis.
We review insights in signaling pathways controlling cell polarization and cytoskeletal organization during chemotactic movement in Dictyostelium amoebae and neutrophils. We compare and contrast these insights with our current understanding of pathways controlling chemotactic movements in more-complex multicellular developmental contexts.
Affolter
Markus
M
Department of Cell Biology, Biozentrum University of Basel, Klingelbergstr. 70, CH-4056 Basel, Switzerland.
Weijer
Cornelis J
CJ
D000199:Actins / Q000502:physiology; D000818:Animals; D016764:Cell Polarity; D002633:Chemotaxis / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology*; D004023:Dictyostelium / Q000502:physiology; D004330:Drosophila / Q000502:physiology; D005775:Gastrula / Q000502:physiology; D009218:Myosins / Q000502:physiology; D009504:Neutrophils / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology; D015398:Signal Transduction; D014714:Vertebrates / Q000196:embryology / Q000502:physiology
D000199:Actins; D020794:Receptor Protein-Tyrosine Kinases; D009218:Myosins