The promise of microarrays in the management and treatment of breast cancer.
Breast cancer is the most common malignancy afflicting women from Western cultures. Developments in breast cancer molecular and cellular biology research have brought us closer to understanding the genetic basis of this disease. Recent advances in microarray technology hold the promise of further increasing our understanding of the complexity and heterogeneity of this disease, and providing new avenues for the prognostication and prediction of breast cancer outcomes. These new technologies have some limitations and have yet to be incorporated into clinical use, for both the diagnosis and treatment of women with breast cancer. The most recent application of microarray genomic technologies to studying breast cancer is the focus of this review.
Chang
Jenny C
JC
Breast Center, Baylor College of Medicine, Houston, Texas, USA. jcchang@breastcenter.tmc.edu
Hilsenbeck
Susan G
SG
Fuqua
Suzanne A W
SA
D001943:Breast Neoplasms / Q000235:genetics* / Q000628:therapy*; D005260:Female; D020869:Gene Expression Profiling; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D010347:Patient Care Planning; D011379:Prognosis
D005819:Genetic Markers