Frequent detection of Kaposi's sarcoma herpesvirus in germinal centre macrophages from AIDS-related multicentric Castleman's disease.
Kaposi's sarcoma-associated herpesvirus (KSHV), the causative agent of Kaposi's sarcoma is able to infect several cell types. By investigating hyperplastic lymph nodes from AIDS patients with multicentric Castleman's disease, we demonstrate, for the first time, by dual colour immunohistochemistry, that KSHV is frequently detectable in germinal centre macrophages. These macrophages, which display a latency programme and frequently contain apoptotic bodies, may represent a non-negligible reservoir for the virus in lymphoid organs.
Valmary
Severine
S
Laboratoire d'Anatomie Pathologique, Unité Inserm U563/CPTP, Centre Hospitalier Universitaire de Purpan, 31059 Toulouse Cedex, France.
Richard
Pomone
P
Brousset
Pierre
P
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis*; D005871:Castleman Disease / Q000821:virology*; D019288:Herpesvirus 8, Human / Q000302:isolation & purification* / Q000502:physiology; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008264:Macrophages / Q000821:virology*; D012514:Sarcoma, Kaposi / Q000175:diagnosis*; D017735:Virus Latency