C-C chemokine receptor 5 gene variants in relation to lung disease in sarcoidosis.
BACKGROUND
Genetic factors are likely to influence the clinical course and pattern of sarcoidosis, a granulomatous disease of unknown origin.


OBJECTIVE
We tested this hypothesis for C-C chemokine receptor 5 (CCR5), a molecule involved in recruitment and activation of mononuclear cells.


METHODS
In addition to the known CCR5 Delta 32 insertion/deletion, we evaluated a further eight single-nucleotide polymorphisms in 106 British patients and 142 British unaffected subjects, and second-setted the results in 112 Dutch patients and 169 healthy Dutch control subjects.


RESULTS
In the British population, the frequency of one of the identified haplotypes (HHC) was strongly associated with the presence of parenchymal disease (radiographic stage >or= II versus stages 0 and I) at presentation (odds ratio [OR], 5.2; 95% confidence interval [CI], 1.96-13.7; corrected p = 0.02), at 2 (OR, 6.6; 95% CI, 2.5-17.6; corrected p = 0.006), and at 4 years follow-up (OR, 6.8; 95% CI, 2.5-18.0; corrected p = 0.0045). In the Dutch population, the same association was seen at 2 (OR, 6.7; 95% CI, 2.8-16.4; corrected p = 0.002), and 4 years follow-up (OR, 9.0; 95% CI, 3.5-23.1; corrected p = 0.0009).


CONCLUSIONS
No association between the CCR5 haplotype HHC and susceptibility to sarcoidosis was observed, indicating that this relevant gene only operates after disease induction. In summary, we report a strong association between CCR5 haplotype HHC and persistent lung involvement in sarcoidosis.
Spagnolo
Paolo
P
Clinical Genomic Group, National Heart and Lung Institute, Department of Occupational and Environmental Medicine, Imperial College of Science, Technology and Medicine, London, UK. p.spagnolo@imperial.ac.uk
Renzoni
Elisabetta A
EA
Wells
Athol U
AU
Copley
Susan J
SJ
Desai
Sujal R
SR
Sato
Hiroe
H
Grutters
Jan C
JC
Abdallah
Atiyeh
A
Taegtmeyer
Anne
A
du Bois
Roland M
RM
Welsh
Kenneth I
KI
D016022:Case-Control Studies; D004739:England; D005500:Follow-Up Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D009426:Netherlands; D020641:Polymorphism, Single Nucleotide; D013902:Radiography, Thoracic; D019713:Receptors, CCR5 / Q000235:genetics*; D017565:Sarcoidosis, Pulmonary / Q000000981:diagnostic imaging / Q000208:ethnology / Q000235:genetics*; D044465:White People / Q000235:genetics
D019713:Receptors, CCR5