[Multicentric reticulohistiocytosis: report of a case with systemic disease].
Multicentric reticulohistiocytosis (RHM) is a rare non Langherhans cell histiocytosis with skin and joint involvment. Nearly all organs can be involved. Association with cancer occurs in about 25% of cases. Association with auto-immune diseases has also been recorded. Microscopic examination shows a histiocytic nodular infiltrate made of giant cells with ground-glass appearance and PAS positive cytoplasm. Immunostaining shows cell positivity for CD68 and negativity for CD1a and S100 protein. No Birbeck granules are found at ultrastructural examination.
Stock
Nathalie
N
Département d'Anatomie Pathologique, CHU Pontchaillou, 2 rue H. Le Guillou, 35033 Rennes 9.
Saikali
Stephan
S
Chevrant-Breton
Jacqueline
J
Leroy
Jean-Pierre
JP
Le Gall
François
F
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D003593:Cytoplasm / Q000473:pathology; D005260:Female; D006644:Histiocytes / Q000473:pathology; D015616:Histiocytosis, Non-Langerhans-Cell / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008854:Microscopy, Electron; D009132:Muscles / Q000473:pathology; D010503:Periodic Acid-Schiff Reaction; D012867:Skin / Q000473:pathology; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule