Mathematical models of cell cycle regulation.
The cell division cycle is a fundamental process of cell biology and a detailed understanding of its function, regulation and other underlying mechanisms is critical to many applications in biotechnology and medicine. Since a comprehensive analysis of the molecular mechanisms involved is too complex to be performed intuitively, mathematical and computational modelling techniques are essential. This paper is a review and analysis of recent approaches attempting to model cell cycle regulation by means of protein-protein interaction networks.
Fuss
Hendrik
H
School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, BT52 1SA, UK. fuss-h@ulster.ac.uk
Dubitzky
Werner
W
Downes
C Stephen
CS
Kurth
Mary Jo
MJ
D000465:Algorithms; D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D003198:Computer Simulation; D005246:Feedback / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*
D018797:Cell Cycle Proteins