Cerebellar cortical degeneration in three English bulldogs: clinical and neuropathological findings.
This case report describes the clinical and neuropathological findings in three young English bulldogs affected by cerebellar cortical degeneration. The dogs, born from the same parents, were presented with clinical signs indicating progressive cerebellar dysfunction: a wide-based stance, severe cerebellar ataxia characterised by marked hypermetria, spasticity, and intention tremors of the head and trunk with loss of balance. On histopathological examination, lesions were confined to the cerebellum and consisted of diffuse degenerative cortical lesions, and there was a loss of Purkinje and granule cells. The history, clinical signs and neuropathological findings confirmed the diagnosis of cerebellar cortical degeneration. To the authors' knowledge, this is the first report of cerebellar cortical degeneration in the English bulldog.
Department of Veterinary Clinical Sciences, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano Emilia, Bologna, Italy.
G
G
Gandini
C
C
Botteron
E
E
Brini
R
R
Fatzer
A
A
Diana
A
A
Jaggy
D000818:Animals; D002524:Cerebellar Ataxia / Q000175:diagnosis / Q000662:veterinary; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D004285:Dogs; D008297:Male; D009460:Neurologic Examination / Q000662:veterinary; D010375:Pedigree; D013132:Spinocerebellar Degenerations / Q000175:diagnosis / Q000662:veterinary*