[Diagnostic and prognostic value of the oncoprotein her-2/neu in the breast cancer tissue].
49 breast cancer tissues were investigated by imunnohistochemical method, to reveal the expression and distribution of the oncoprotein HER-2/neu. It was found, that expression of the oncoprotein HER-2/neu in the tumor tissues is very variable, which depends on the cancer histogenesis, histological form, differentiation and stage of tumor development. Intensity of expression of the oncoprotein HER-2/neu is higher in the ductal forms of the cancer, there is reciprocal relationship between the intensity of the expression of the oncoprotein HER-2/neu and steroid hormones. Using these data we can define histogenesis, rate of maturation and other tumor features in more objective manner. This is very important for selection of the breast cancer treatment methods.
A. Natishvili Institute of Experimental Morphology, Academy of Sciences of Georgia.
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M
Mchedlishvili
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U
Gabunia
D001943:Breast Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis*
D018719:Erb-b2 Receptor Tyrosine Kinases