In vitro and in vivo bactericidal activities of vancomycin dispersed in porous biodegradable poly(epsilon-caprolactone) microparticles.
Treatment of methicillin-resistant Staphylococcus aureus osteomyelitis requires a prolonged antibiotic therapy with vancomycin. Because of its weak diffusion, the in situ implantation of vancomycin could be interesting. The activity of vancomycin encapsulated in microparticles was evaluated in vitro and in vivo on rabbit osteomyelitis and showed a good activity compared to intravenous administration.
Centre de Recherche sur les Matériaux d'Intérêt Biologique, Equipe INSERM 99-03, UFR Odontologie, University of Nantes, 1 rue Gaston Veil, 44035 Nantes, France.
Anne-Marie
AM
Le Ray
Hélène
H
Gautier
Marie-Katel
MK
Laty
Guy
G
Daculsi
Christian
C
Merle
Cédric
C
Jacqueline
Antoine
A
Hamel
Jocelyne
J
Caillon
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000494:pharmacology; D002208:Caproates / Q000494:pharmacology*; D015169:Colony Count, Microbial; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D007783:Lactones / Q000494:pharmacology*; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests / Q000379:methods; D010019:Osteomyelitis / Q000188:drug therapy* / Q000382:microbiology; D011817:Rabbits; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D014640:Vancomycin / Q000008:administration & dosage / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D002208:Caproates; D003692:Delayed-Action Preparations; D007783:Lactones; C121056:caprolactone; D014640:Vancomycin