[Muriatic secretion and acid-proteolytic activity of the stomach in vivo].
The study of the basal (BAP) and stimulated (SAP) acid production effect on the average daily acidity and speed of proteolysis in the stomach in vivo was conducted in 498 patients with various functional states of the stomach. It was established that the aforesaid muriatic secretion indices influence the acidity and speed of proteolysis in natural conditions of digestion only within the low and normal range of their values. In the condition of HCl hypersecretion, the dependence between the muriatic secretion and acidity and proteolytic stomach activity in vivo gets lost. This can be explained by the autoregulation effect supporting the introgastral pH optimal for pepsin activity irrespective of the intensity of the acid glands hyperplasia.
V A
VA
Gorshkov
T N
TN
Zhigalova
E B
EB
Avalueva
D000293:Adolescent; D000328:Adult; D000368:Aged; D004063:Digestion; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D010434:Pepsin A / Q000378:metabolism; D013270:Stomach / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D013272:Stomach Diseases / Q000503:physiopathology*
D006632:Histamine; D010434:Pepsin A