Expression of slow skeletal myosin binding C-protein in normal adult mammalian heart.
Myosin binding C-protein exists in three main isoforms in striated muscle. While expression of cardiac muscle type C-protein is detected in skeletal muscle during early fetal development, there have not so far been any reports of the expression of the skeletal muscle isoforms of this protein in either developing or adult vertebrate heart. The present study demonstrates slow skeletal muscle type C-protein in moderate amount in right atrium and interatrial septum of adult human, rabbit, rat and bovine hearts using both immunocytochemical and immunoblotting procedures.
Department of Basic Sciences, The Royal Veterinary College, London, NW1 OTU, UK. tdhoot@rvc.ac.uk
Gurtej K
GK
Dhoot
Samuel V
SV
Perry
D000328:Adult; D000818:Animals; D015153:Blotting, Western; D002352:Carrier Proteins / Q000378:metabolism*; D002417:Cattle; D015870:Gene Expression; D006321:Heart / Q000502:physiology*; D006325:Heart Atria / Q000378:metabolism; D006346:Heart Septum / Q000378:metabolism; D006352:Heart Ventricles / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D009206:Myocardium / Q000378:metabolism*; D009218:Myosins / Q000378:metabolism; D011817:Rabbits; D000099163:Myosin Binding Protein C
D002352:Carrier Proteins; D009218:Myosins; D000099163:Myosin Binding Protein C