Gram-scale synthesis of (-)-epibatidine.
[reaction: see text] A gram-scale approach toward (-)-epibatidine (1, naturally occurring enantiomer), a novel class of amphibian alkaloid, has been developed from readily available starting materials using mild and easily controlled reactions. The entire synthetic route is straightforward and convenient for gram-scale synthesis.
Lee
Chi-Lik Ken
CL
Department of Chemistry, National University of Singapore.
Loh
Teck-Peng
TP
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D000663:Amphibians; D000818:Animals; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000470:Alkaloids; D019086:Bridged Bicyclo Compounds, Heterocyclic; D011725:Pyridines; C082748:epibatidine