[Histopathological study of the effects of intra-articular injection of triamcinolone acetonide on temporomandibular joint osteoarthrosis in goats].
OBJECTIVE
The aim of this study was to investigate the histopathological changes of human temporomandibular joint osteoarthrosis following intra-articular injection of triamcinolone acetonide, and compare the results to these of control group.


METHODS
The upper compartments of both joints of 10 goats were injected with 0.8 ml collagenase I to induce osteoarthrosis. The 10 goats were then equally divided into control group and experimental group. The first and second treatment were carried out 30 and 60 days after injection of collagenase I, respectively. The animals were sacrificed 90 days after the first treatment. The specimens of the animal TMJ were harvested, histologically examined under light microscopy and scanning electron microscopy, and scored in a subjective manner following the criteria which was a modification of the method of Mankin et al and Yoshimi et al. GLM model in SAS software package was adopted to compare the differences between the control group and experimental group.


RESULTS
Under light microscopy and scanning electron microscopy, the condyle, meniscus and glenoid fossa of the control group demonstrated distinct osteoarthrosis; the histopathologic changes in the experimental group was more serious than the control group, and the differences of the histologic scores were significant between the two groups (P<0.01).


CONCLUSIONS
Intra-articular injection of triamcinolone acetonide as a lytic agent will worsen for articular cartilage reparation.
Department of Oral and Maxillofacial Surgery, Second Hospital of Shandong University, Jinan 250033, Shandong Province, China. ykf1963@126.com
Kui-feng
KF
Yuan
Qing-guo
QG
Lai
Dai-hui
DH
Song
Rong-ji
RJ
Shi
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D002358:Cartilage, Articular; D006041:Goats; D006801:Humans; D007270:Injections, Intra-Articular; D010003:Osteoarthritis / Q000188:drug therapy*; D013705:Temporomandibular Joint Disorders / Q000188:drug therapy*; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*
D000893:Anti-Inflammatory Agents; D014222:Triamcinolone Acetonide