Comparison of the Bravo wireless and Digitrapper catheter-based pH monitoring systems for measuring esophageal acid exposure.
BACKGROUND
We compared esophageal acid exposure data obtained during simultaneous esophageal pH studies using the Bravo wireless and the Slimline catheter-Mark III Digitrapper pH systems.


METHODS
Twenty-five asymptomatic subjects underwent endoscopy with endoclip placement at the squamocolumnar junction (SCJ) and manometry to localize the lower esophageal sphincter (LES). A Bravo capsule was placed 6 cm above the SCJ and a Slimline catheter 5 cm above the LES. Relative positions were checked fluoroscopically. Synchronized pH data were compared by manual extraction into Excel spreadsheets. An in vivo pH reference was established with swallows of orange juice (pH 3.88).


RESULTS
Median acid exposure time was greater with the Slimline compared to the Bravo system (Slimline, 3.4%; Bravo, 1.76%, p < 0.05) but electrode positions were similar. The dominant source of discrepancy between systems was an offset in recorded pH values around pH 4 as evidenced by the recorded values of the swallowed orange juice. Bench-top testing suggested that this offset was mainly attributable to the software designed to compensate for the difference in electrode recording characteristics between room and body temperature. After adjusting the pH data sets to accurately reflect actual orange juice pH, acid exposure between systems was similar (Slimline, 0.90%; Bravo, 1.15%).


CONCLUSIONS
The Slimline system on average over-recorded esophageal acid exposure compared to the Bravo system largely because of a flawed software scheme for electrode thermal calibration. Accuracy of pH data sets from both systems can be improved by scrutiny for artifacts and use of an in vivo pH reference.
Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.
John E
JE
Pandolfino
Mitchal A
MA
Schreiner
Thomas J
TJ
Lee
Qing
Q
Zhang
Christopher
C
Boniquit
Peter J
PJ
Kahrilas
D000143:Acids / Q000378:metabolism*; D000328:Adult; D001628:Beverages; D002138:Calibration; D002404:Catheterization; D032084:Citrus sinensis; D003679:Deglutition; D004566:Electrodes; D001330:Electronic Data Processing; D004947:Esophagus / Q000378:metabolism*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D018670:Monitoring, Ambulatory / Q000295:instrumentation* / Q000592:standards*; D012016:Reference Values; D013696:Temperature
D000143:Acids