Functional polymorphism of the glutathione peroxidase 1 gene is associated with personality traits in healthy subjects.
BACKGROUND
Several lines of evidence suggest that a certain type of personality or temperament as well as oxidative stress may be implicated in the pathophysiology of neuropsychiatric diseases. Glutathione peroxidase 1 (GPX1) plays a role in the antioxidant defense system.


OBJECTIVE
The authors studied the association between the GPX1 gene polymorphism and personality traits in healthy subjects.


METHODS
One hundred forty-nine healthy subjects were enrolled. Analysis of the functional polymorphism (Pro198Leu) in the human GPX1 gene was performed.


RESULTS
Subjects with Pro198Pro have significantly higher scores in openness to experience on the Revised NEO Personality Inventory (NEO-PI-R) as compared with subjects with other genotypes (Pro198Leu or Leu198Leu). In contrast, we detected no association between other personality dimensions on the NEO-PI-R and scores on the Temperament and Character Inventory.


CONCLUSIONS
This study reports that the functional polymorphism (Pro198Leu) in the GPX1 gene might be associated with openness to experience among the personality traits.
Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan.
Daisuke
D
Matsuzawa
Kenji
K
Hashimoto
Eiji
E
Shimizu
Mihisa
M
Fujisaki
Masaomi
M
Iyo
D000328:Adult; D000704:Analysis of Variance; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D005979:Glutathione Peroxidase / Q000235:genetics*; D006801:Humans; D007564:Japan / Q000208:ethnology; D007930:Leucine / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010551:Personality / Q000235:genetics*; D010555:Personality Inventory / Q000706:statistics & numerical data; D011110:Polymorphism, Genetic / Q000235:genetics*; D011392:Proline / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D000094765:Glutathione Peroxidase GPX1
D012333:RNA, Messenger; D011392:Proline; D005979:Glutathione Peroxidase; D007930:Leucine; D000094765:Glutathione Peroxidase GPX1; C000722067:GPX1 protein, human