Radiosynthesis of carbon-11-labeled camptothecin derivatives as potential positron emission tomography tracers for imaging of topoisomerase I in cancers.
Four carbon-11-labeled camptothecin derivatives, 9-[11C]methoxy-20(S)-camptothecin ([11C]5), 10-[11C]methoxy-20(S)-camptothecin ([11C]7), 9-nitro-10-[11C]methoxy-20(S)-camptothecin ([11C]9), and 9-[([11C]trimethylamino)methyl]-10-hydroxy-20(S)-camptothecin ([11C]11), have been synthesized as potential positron emission tomography tracers for imaging of topoisomerase I in cancers.
Department of Radiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Mingzhang
M
Gao
Kathy D
KD
Miller
George W
GW
Sledge
Qi-Huang
QH
Zheng
D002166:Camptothecin / Q000138:chemical synthesis; D002250:Carbon Radioisotopes; D004264:DNA Topoisomerases, Type I; D006801:Humans; D009369:Neoplasms / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography / Q000379:methods*; D011877:Radionuclide Imaging / Q000379:methods; D019275:Radiopharmaceuticals / Q000138:chemical synthesis; D013329:Structure-Activity Relationship
D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D004264:DNA Topoisomerases, Type I; D002166:Camptothecin