Characteristics of Epstein-Barr virus associated childhood non-Hodgkin's lymphoma in the Republic of Korea.
To analyze the clinicopathologic characteristics of childhood non-Hodgkin's lymphoma (NHL) associated with Epstein-Barr virus (EBV), EBER in situ hybridization was performed in 80 cases of NHLs. EBER-positive lymphomas account for 25% (20/80) and include NK/T-cell lymphoma (6/6), aggressive NK-cell leukemia (1/1), peripheral T cell lymphoma (5/11), diffuse large B-cell lymphoma (5/14), hydroa-like T-cell lymphoma (1/1), marginal zone B-cell lymphoma (1/2), and post-transplantation lymphoproliferative disorder (1/1). Other types including 19 cases of Burkitt's lymphoma were negative. For 9 EBER-positive cases, immunohistochemical staining for LMP-1, and EBNA-2 was performed to determine the EBV latency pattern. Two of nine EBER-positive cases expressed both LMP-1 and EBNA-2. Clinically, patients with EBV-positive B-cell lymphomas were cured with chemotherapy, whereas EBV-associated NK- and T cell lymphomas pursued fatal clinical course. In conclusion, EBVs infected in childhood NHLs are frequently associated not only with NK- and T- cell lymphomas but also large B-cell lymphomas.
Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Kangnam-gu, Ilwon-dong 50, 135-710 Seoul, South Korea.
DongHoon
D
Kim
YoungHyeh
Y
Ko
Yeonlim
Y
Suh
HongHoe
H
Koo
JooRyung
J
Huh
WonKeun
W
Lee
D000293:Adolescent; D002648:Child; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology*; D019309:Epstein-Barr Virus Nuclear Antigens / Q000096:biosynthesis; D005260:Female; D004854:Herpesvirus 4, Human / Q000502:physiology; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007723:Korea; D008228:Lymphoma, Non-Hodgkin / Q000821:virology*; D008297:Male; D016601:RNA-Binding Proteins / Q000096:biosynthesis; D012269:Ribosomal Proteins / Q000096:biosynthesis; D012737:Sex Factors; D014412:Tumor Virus Infections / Q000453:epidemiology*; D014763:Viral Matrix Proteins / Q000096:biosynthesis; D014764:Viral Proteins; D017735:Virus Latency
C402641:EBNA-2 protein, Human herpesvirus 4; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D019309:Epstein-Barr Virus Nuclear Antigens; D016601:RNA-Binding Proteins; D012269:Ribosomal Proteins; D014763:Viral Matrix Proteins; D014764:Viral Proteins; C067169:RPL22 protein, human