In vivo effect of piperine on serum and tissue glycoprotein levels in benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice.
In recent years, considerable emphasis has been focused on identifying new cancer chemopreventive agents, which could be useful for the human population. Piperine is a pure, pungent alkaloid constituent of black and long peppers (Piper nigrum and Piper longum), that acts as an antioxidant and anticancer agent by its numerous macromolecules associated with them. In the present study, piperine was found to suppress benzo(a)pyrene (B(a)p) induced lung cancer in Swiss albino mice. In lung cancer bearing mice, altered levels of total protein and protein bound carbohydrate components (hexose, hexosamine and sialic acid) were observed in serum, lung and liver tissues. Dietary supplementation of piperine (50 mg/kg body weight) to B(a)p administered animals decreased the total protein and protein bound carbohydrate levels of lung cancer bearing animals in during initiation and post-initiation phases. Our data suggest that piperine may extend its chemopreventive effect through modulating the protein bound carbohydrate levels, as they are one of the indicators of tumorigenesis.
Department of Medical Biochemistry, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India. selvakphd@yahoo.com
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Selvendiran
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Prince Vijeya Singh
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Sakthisekaran
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001564:Benzo(a)pyrene; D052117:Benzodioxoles; D006023:Glycoproteins / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008175:Lung Neoplasms / Q000139:chemically induced / Q000401:mortality / Q000517:prevention & control*; D008297:Male; D051379:Mice; D010880:Piperidines / Q000494:pharmacology*; D053284:Polyunsaturated Alkamides
D000470:Alkaloids; D000970:Antineoplastic Agents; D000975:Antioxidants; D052117:Benzodioxoles; D006023:Glycoproteins; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D001564:Benzo(a)pyrene; C008922:piperine