Catalytic Pictet-Spengler reactions using Yb(OTf)3.
The catalytic Pictet-Spengler reactions proceeded in high yields with high regioselectivity in the presence of a catalytic amount of Yb(OTf)3 and a dehydrating agent at room temperature. High regioselectivities were obtained in these reactions, and it is suggested that the reactions proceeded under kinetic control.
Manabe
Kei
K
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Nobutou
Daisuke
D
Kobayashi
Shū
S
D002384:Catalysis; D007546:Isoquinolines / Q000737:chemistry; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015018:Ytterbium / Q000737:chemistry*
D007546:Isoquinolines; D015018:Ytterbium