The first water channel protein (later called aquaporin 1) was first discovered in Cluj-Napoca, Romania.
This invited review briefly outlines the importance of membrane water permeability, highlights the landmarks leading to the discovery of water channels. After a decade of systematic studies on water channels in human RBC Benga's group discovered in 1985 the presence and location of the water channel protein among the polypeptides migrating in the region of 35-60 kDa on the electrophoretogram of RBC membrane proteins. The work was extended and reviewed in several articles. In 1988, Agre and coworkers isolated a new protein from the RBC membrane, nick-named CHIP28 (channel-forming integral membrane protein of 28 kDa). However, in addition to the 28 kDa component, this protein had a 35-60 kDa glycosylated component, the one detected by the Benga's group. Only in 1992 Agre's group suggested that "it is likely that CHIP28 is a functional unit of membrane water channels". Half of the 2003 Nobel Prize in Chemistry was awarded to Peter Agre (Johns Hopkins University, Baltimore, USA) "for the discovery of water channels", actually the first water channel protein from the human red blood cell (RBC) membrane, known today as aquaporin 1 (AQP1). The seminal contributions from 1986 of the Benga's group were grossly overlooked by Peter Agre and by the Nobel Prize Committee. Thousands of science-related professionals from hundreds of academic and research units, as well as participants in several international scientific events, have signed as supporters of Benga; his priority is also mentioned in several comments on the 2003 Nobel Prize.
Benga
Gheorghe
G
Department of Cell and Molecular Biology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. gbenga@personal.ro
D051398:Aquaporin 1; D020346:Aquaporins / Q000097:blood / Q000266:history* / Q000378:metabolism; D001692:Biological Transport; D001789:Blood Group Antigens; D002463:Cell Membrane Permeability; D004910:Erythrocyte Membrane / Q000378:metabolism; D049673:History, 20th Century; D006801:Humans; D009613:Nobel Prize; D012383:Romania; D009626:Terminology as Topic; D014867:Water / Q000378:metabolism*
C496020:AQP1 protein, human; D020346:Aquaporins; D001789:Blood Group Antigens; D014867:Water; D051398:Aquaporin 1