Negative priming in schizophrenia revisited.
Reduced spatial negative priming (SNP) in schizophrenia is commonly attributed to the inability to filter out irrelevant information. However, some investigators have suggested that reduced SNP in patients is caused by either perceptual mismatching or salience of the distracter. The goal of the present study was to determine the influence of these perceptual processes. In this preliminary report, we present data of 15 schizophrenia patients on atypical medication and 15 matched healthy controls. Compared to controls, patients showed a reduced SNP effect, even when controlled for perceptual mismatching. This reduced effect was not affected by distracter salience.
Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Department of Psychiatry, Heidelberglaan 100, 3584CX Utrecht, The Netherlands.
M
M
Vink
N F
NF
Ramsey
M
M
Raemaekers
R S
RS
Kahn
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D010364:Pattern Recognition, Visual / Q000187:drug effects / Q000502:physiology*; D010470:Perceptual Masking / Q000502:physiology; D011569:Psychiatric Status Rating Scales; D011930:Reaction Time / Q000502:physiology; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D013028:Space Perception / Q000187:drug effects / Q000502:physiology*
D014150:Antipsychotic Agents