Does resistance to pyrazinamide accurately indicate the presence of Mycobacterium bovis?
Mycobacterium bovis is best identified by screening those isolates of the Mycobacterium tuberculosis complex that have any pyrazinamide (PZA) resistance, using a confirmatory test such as spoligotyping, biochemical testing, or genomic deletion analysis. The sensitivity for detection of M. bovis is lowered to 82% when only PZA-monoresistant isolates are screened.
Division of Infectious Diseases, Stanford University, Stanford, California, USA. bouke@stanford.edu
Bouke C
BC
de Jong
Anthony
A
Onipede
Alex S
AS
Pym
Sebastien
S
Gagneux
Roxanne S
RS
Aga
Kathryn
K
DeRiemer
Peter M
PM
Small
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000494:pharmacology*; D015373:Bacterial Typing Techniques; D002648:Child; D024881:Drug Resistance, Bacterial; D017353:Gene Deletion; D006801:Humans; D008826:Microbial Sensitivity Tests; D009163:Mycobacterium bovis / Q000145:classification* / Q000187:drug effects* / Q000235:genetics; D009841:Oligonucleotides / Q000032:analysis; D011718:Pyrazinamide / Q000494:pharmacology*; D014376:Tuberculosis / Q000382:microbiology
D000995:Antitubercular Agents; D009841:Oligonucleotides; D011718:Pyrazinamide