Ropinirole in the treatment of Parkinson's disease.
In this review, the pharmacokinetics, safety and tolerability, and clinical efficacy of ropinirole (Requip), a non-ergoline dopamine agonist approved for use in the treatment of Parkinson's disease (PD) are examined. A summary of preclinical and clinical studies is presented. Ropinirole is safe and efficacious as monotherapy in the treatment of early PD and as an adjunct to levodopa in more advanced cases.
Parkinson's Disease and Movement Disorders Center, University of South Florida, 4 Colombia Drive, Suite 410, Tampa, Florida 33606, USA.
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Zesiewicz
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Hauser