Heparin, low molecular weight heparin, and heparin-induced thrombocytopenia in the ICU.
Thrombocytopenia is common in critically ill patients who receive heparin. However, heparin-induced thrombocytopenia (HIT) is a relatively uncommon explanation for thrombocytopenia in this patient population. This article describes clinical features of HIT and interpretation of laboratory tests for HIT antibodies from the perspective of the intensive care unit.
Warkentin
Theodore E
TE
Hamilton Regional Laboratory Medicine Program, Hamilton Health Sciences, 237 Barton Street East, Hamilton, Ontario L8L 2X2, Canada. twarken@mcmaster.ca
Cook
Deborah J
DJ
D000925:Anticoagulants / Q000009:adverse effects*; D006495:Heparin, Low-Molecular-Weight / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D007362:Intensive Care Units; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy
D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight