No changes in serum epidermal growth factor levels in patients with schizophrenia.
A recent report demonstrated that serum levels of epidermal growth factor (EGF) were significantly decreased in patients with schizophrenia, suggesting that impaired EGF signaling might be associated with the pathophysiology of schizophrenia. Our goal in the present study was to determine whether serum levels of EGF are altered in patients with schizophrenia. We found that serum levels of EGF in drug-naive (n = 15) or medicated patients (n = 25) with schizophrenia did not differ from those of age- and sex-matched normal controls (n = 40). However, we found a significant correlation between serum EGF levels and BPRS scores in the combined groups of patients. Therefore, our results do not support the claim that EGF plays a role in the pathogenesis of schizophrenia, but they suggest that EGF may serve as a state marker, that is, as an index of symptom-linked deficits.
Hashimoto
Kenji
K
Department of Psychiatry, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chiba 260-8670, Japan. hashimoto@faculty.chiba-u.jp
Shimizu
Eiji
E
Komatsu
Naoya
N
Watanabe
Hiroyuki
H
Shinoda
Naoyuki
N
Nakazato
Michiko
M
Kumakiri
Chikara
C
Okada
Shin-ichi
S
Takei
Nori
N
Iyo
Masaomi
M
D000328:Adult; D010054:Brief Psychiatric Rating Scale; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004815:Epidermal Growth Factor / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D009414:Nerve Growth Factors / Q000097:blood; D012559:Schizophrenia / Q000097:blood* / Q000175:diagnosis
D009414:Nerve Growth Factors; D004815:Epidermal Growth Factor