In situ-gelling, erodible N-isopropylacrylamide copolymers.
Copolymers of N-isopropylacrylamide, 2-hydroxyethyl methacryl lactate [(HEMA)-lactate] and acrylic acid (AAc) were prepared with varying mole ratios of monomers to develop copolymers with gelation properties above a certain concentration for a bioerodible, in-situ gelling material. The copolymers formed gels in situ under physiological condition. The gelation temperature of the copolymers decreased as the HEMA-lactate content of the copolymers increased due to the hydrophobicity of HEMA-lactate, and increased as the AAc content increased due to the hydrophilicity of AAc. The gels redissolve at 37 degrees C as their LCSTs increase above 37 degrees C due to the hydrolysis of the HEMA-lactate pendant groups.
The Harrington Department of Bioengineering, Arizona State University, ECG 334, Tempe, AZ 85287-9709, USA.
Bae Hoon
BH
Lee
Brent
B
Vernon
D000178:Acrylamides / Q000737:chemistry*; D000179:Acrylates / Q000737:chemistry; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D005782:Gels / Q000138:chemical synthesis / Q000737:chemistry*; D006868:Hydrolysis; D007773:Lactates / Q000737:chemistry; D008689:Methacrylates / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D013696:Temperature
D000178:Acrylamides; D000179:Acrylates; D001672:Biocompatible Materials; D005782:Gels; D007773:Lactates; D008689:Methacrylates; D011108:Polymers; C005044:hydroxyethyl methacrylate; C067295:N-isopropylacrylamide; C036658:acrylic acid