Intravesical ozone therapy for progressive radiation-induced hematuria.
BACKGROUND
Progressive radiation-induced cystitis can become a serious clinical problem the therapeutic solution of which is limited and almost invariably aggressive. Ozone therapy is a nonconventional therapy that has been reported to offer benefits in late-onset wound healing and ischemic disorders. This report describes a patient with progressive radiation-induced hematuria from standard conservative treatment that was further treated with ozone therapy.


METHODS
Ozone therapy was achieved by intravesical instillation of ozonized bi-distilled water over a period of 30 minutes, three sessions per week during the first weeks. Later, ozone therapy sessions were decreased and involved ozonized water or direct intravesicular instillation of ozone at 20-25 microg/mL.


RESULTS
Hematuria was successfully controlled by intravesical application of ozone therapy.


CONCLUSIONS
The successes achieved with this technique suggest that intravesicular instillation of ozonized bi-distilled water or ozone merits further investigation with a view to its application to counter this radiation-induced side-effect.
Department of Radiation Oncology, Research Unit, Dr. Negrin University Hospital, Las Palmas, Spain. bernardinoclavo@terra.es
Bernardino
B
Clavo
Dominga
D
Gutiérrez
Dionisio
D
Martín
Gerardo
G
Suárez
María A
MA
Hernández
Francisco
F
Robaina
D000368:Aged; D003556:Cystitis / Q000209:etiology* / Q000628:therapy*; D006417:Hematuria / Q000209:etiology* / Q000628:therapy*; D006801:Humans; D007322:Instillation, Drug; D008297:Male; D010126:Ozone / Q000008:administration & dosage*; D011471:Prostatic Neoplasms / Q000532:radiotherapy; D011832:Radiation Injuries / Q000150:complications / Q000209:etiology / Q000628:therapy*; D011878:Radiotherapy / Q000009:adverse effects; D016896:Treatment Outcome; D014867:Water / Q000008:administration & dosage
D014867:Water; D010126:Ozone