Phenatic acids A and B, new potentiators of antifungal miconazole activity produced by Streptomyces sp. K03-0132.
Two new phenols, designated phenatic acids A and B, were isolated along with known actiphenol, from the culture of Streptomyces sp. K03-0132 by solvent extraction, silica gel column chromatography and HPLC. Their structures were elucidated by spectroscopic analyses including mainly various NMR experiments. They have a common 1-hydroxy 2, 4-dimethyl benzene ring. These compounds potentiate miconazole activity against Candida albicans. Phenatic acid B also showed moderate antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Bacteroides fragilis and Acholeplasma laidlawii.
Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
Takashi
T
Fukuda
Atsuko
A
Matsumoto
Yoko
Y
Takahashi
Hiroshi
H
Tomoda
Satoshi
S
Omura
D000085:Acetates / Q000378:metabolism* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000096:biosynthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004357:Drug Synergism; D005285:Fermentation; D005977:Glutarates / Q000378:metabolism* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008825:Miconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010636:Phenols / Q000378:metabolism* / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*
D000085:Acetates; D000935:Antifungal Agents; D005977:Glutarates; D010636:Phenols; C502101:phenatic acid A; C502102:phenatic acid B; D008825:Miconazole