"Applause sign" helps to discriminate PSP from FTD and PD.
The "applause sign" is a simple test of motor control that helps to differentiate PSP from frontal or striatofrontal degenerative diseases. It was found in 0/39 controls, 0 of 24 patients with frontotemporal dementia (FTD), 0 of 17 patients with Parkinson disease (PD), and 30/42 patients with progressive supranuclear palsy (PSP). It discriminated PSP from FTD (p < 0.001) and PD (p < 0.00). The "three clap test" correctly identified 81.8% of the patients in the comparison PSP and FTD and 75% of the patients in the comparison of PSP and PD.
INSERM U 610, Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France. b.dubois@psl.ap-hop-paris.fr
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Dubois
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Slachevsky
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Pillon
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Beato
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Villalponda
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Litvan
D000368:Aged; D001479:Basal Ganglia / Q000503:physiopathology; D003704:Dementia / Q000175:diagnosis* / Q000503:physiopathology; D003937:Diagnosis, Differential; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology; D009069:Movement Disorders / Q000175:diagnosis* / Q000503:physiopathology; D009434:Neural Pathways / Q000503:physiopathology; D009460:Neurologic Examination / Q000379:methods; D010300:Parkinson Disease / Q000175:diagnosis* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011597:Psychomotor Performance / Q000502:physiology; D013494:Supranuclear Palsy, Progressive / Q000175:diagnosis* / Q000503:physiopathology; D014836:Volition / Q000502:physiology