Recruitment and selection of ovarian follicles for determination of ovulation rate in the pig.
Gonadotropins determine the follicle selection and ovulation rate. Follicle growth is independent of gonadotropins until antrum formation, at which time recruitment occurs. Once recruited, follicles will continue to grow or degenerate. In gilts, visible surface follicles are classified as small (<3mm), medium (3-6.9 mm) and large (> or =7.0mm). At estrus (day 0), there are approximately 15 small and medium follicles, and approximately 15 large follicles. By day 3, there may be approximately 30 small, 5 medium and no large follicles. During the remainder of the luteal phase, the pool of follicles increases and peaks at day 11-13 with approximately 50 small, and 30 medium, but with no large follicles observed. By the start of the follicular phase at day 15, numbers of small and medium follicles rapidly decline, while a pool of medium follicles is selected for the ovulation. The size of large follicles at estrus is heterogeneous (6.5-10.0 mm) but their number is reflective of the subsequent number of corpora lutea found following the ovulation. However, the time of medium follicle selection for ovulation is variable during the late luteal and early follicular phases. Suppression of FSH before and at the time of luteolysis reduces medium and large follicles but does not reduce the ovulation rate. In contrast, suppression of FSH for 3 days or unilateral ovariectomy after 3 days of the follicular phase prevents full ovulatory compensation. Therefore, FSH appears to be involved in the maintenance of a pool of medium follicles that can be selected by LH to mature and ovulate.
Department of Animal Sciences, 360 Animal Sciences Laboratory, 1207 West Gregory Drive, University of Illinois, Urbana, IL 61801, USA. rknox@uiuc.edu
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D000818:Animals; D030762:Estrous Cycle / Q000502:physiology; D004971:Estrus; D005260:Female; D005640:Follicle Stimulating Hormone / Q000502:physiology; D005838:Genotype; D007987:Gonadotropin-Releasing Hormone / Q000502:physiology; D007986:Luteinizing Hormone / Q000502:physiology; D003341:Luteolysis / Q000502:physiology; D006080:Ovarian Follicle / Q000033:anatomy & histology / Q000502:physiology*; D010060:Ovulation / Q000235:genetics; D013552:Swine / Q000235:genetics / Q000502:physiology*
D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone