Phenylpyrroles, a new chemolibrary virtual screening class of 5-HT7 receptor ligands.
Virtual screening studies have identified a series of phenylpyrroles as novel 5-HT7 receptor ligands. The synthesis and the affinity for the 5-HT7 receptor of these phenylpyrroles are described. Some of these compounds exhibited high affinity for the 5-HT7 receptors.
Centre d'Etudes et de Recherche sur le Médicament de Normandie, Université de Caen, UFR des Sciences Pharmaceutiques, 5, rue Vaubénard 14032 Caen Cedex, France.
Magalie
M
Paillet-Loilier
Frédéric
F
Fabis
Alban
A
Lepailleur
Ronan
R
Bureau
Sabrina
S
Butt-Gueulle
François
F
Dauphin
Catherine
C
Delarue
Hubert
H
Vaudry
Sylvain
S
Rault
D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis / Q000145:classification* / Q000494:pharmacology*; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects*; D013329:Structure-Activity Relationship
D008024:Ligands; D011758:Pyrroles; D011985:Receptors, Serotonin; C104425:serotonin 7 receptor