The polyol domain of amphidinol 3. A stereoselective synthesis of the entire C(1)-C(30) sector.
[structure: see text] The richly oxygenated C(1)-C(30) polyol segment of amphidinol 3 has been synthesized in protected form. Incorporated in this long chain are 10 of the 25 stereogenic centers housed in the target. The asymmetric pathway that has been developed is based on the efficient union of three independently prepared subunits.
Paquette
Leo A
LA
Evans Chemical Laboratories, The Ohio State University, Columbus, 43210, USA. paquette.1@osu.edu
Chang
Shuh-Kuen
SK
D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry*; D000818:Animals; D004141:Dinoflagellida / Q000737:chemistry; D008293:Malates / Q000737:chemistry; D015394:Molecular Structure; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D000095722:Amphidinols
D000475:Alkenes; D008293:Malates; D011714:Pyrans; C438973:amphidinol 3; D000095722:Amphidinols; C030298:malic acid