A complete mock circulation loop for the evaluation of left, right, and biventricular assist devices.
A new mock circulation loop was developed to replicate the necessary features of the systemic and pulmonic circulatory systems, including pulsatile left and right ventricles coupled with vascular compliances and resistances. A brief description of the mock loop construction is provided before results are presented confirming the recreation of perfusion rates and pressures found in the natural systemic and pulmonic vascular trees for a normal and failing heart at rest. This rig provides the ability to evaluate the hemodynamic effect of left, right, and biventricular assist devices in vitro. The small and compact mock circulation rig has the potential to reduce device evaluation costs by simulating the natural circulatory system, thus providing valuable device performance feedback prior to expensive in vivo animal trials.
Queensland University of Technology, Brisbane, Queensland, Australia. d.timms@qut.edu.au
Daniel
D
Timms
Mark
M
Hayne
Keith
K
McNeil
Andrew
A
Galbraith
D001775:Blood Circulation / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D002319:Cardiovascular System / Q000503:physiopathology*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005112:Extracorporeal Circulation / Q000295:instrumentation*; D006333:Heart Failure / Q000503:physiopathology*; D006353:Heart-Assist Devices; D018056:Hemorheology; D006801:Humans; D008955:Models, Cardiovascular; D014655:Vascular Resistance / Q000502:physiology