Structural diversity of streptokinase and activation of human plasminogen.
The beta domain of streptokinase is required for plasminogen activation and contains a region of sequence diversity associated with infection and disease in group A streptococci. We report that mutagenesis of this polymorphic region does not alter plasminogen activation, which suggests an alternative function for this molecular motif in streptococcal disease.
Department of Microbiology and Immunology, New York Medical College, Valhalla, New York 10595, USA. sergio_lizano@nymc.edu
Sergio
S
Lizano
Kenneth H
KH
Johnston
D000595:Amino Acid Sequence; D008969:Molecular Sequence Data; D010958:Plasminogen / Q000378:metabolism*; D013300:Streptokinase / Q000737:chemistry* / Q000502:physiology; D013329:Structure-Activity Relationship
D010958:Plasminogen; D013300:Streptokinase