Model mis-specification and overestimation of the intraclass correlation coefficient in cluster randomized trials.
Intraclass correlation coefficient (ICC) estimates must be provided when reporting the results of a cluster randomized trial. This study demonstrates that estimating this parameter with one-way ANOVA and an underlying mixed-effects statistical model leads to biased estimates. The bias depends on the effect size of the studied treatment.
Giraudeau
Bruno
B
INSERM CIC 202, Faculté de Médecine, Tours, France. giradeau@med.univ-tours.fr
D016000:Cluster Analysis; D003627:Data Interpretation, Statistical; D015444:Exercise / Q000523:psychology; D006801:Humans; D015233:Models, Statistical; D010003:Osteoarthritis / Q000628:therapy; D010146:Pain / Q000523:psychology; D016032:Randomized Controlled Trials as Topic / Q000379:methods*