[FGF23 and bone metabolism].
Fibroblast growth factor (FGF) 23 was recently shown to alter serum phosphate level by modulating renal tubular phosphate reabsorption and production of active vitamin D independently of parathyroid hormone action. In addition, FGF23 was shown to be involved in the development of several diseases including autosomal dominant hypophosphatemic rickets/osteomalacia (ADHR), X-linked hypophosphatemic rickets/osteomalacia (XLH) and tumor-induced rickets/osteomalacia (TIO). It has also been suggested that FGF23 physiologically regulates serum phosphate level because FGF23 null mice show high serum concentration of phosphate.
Ito
Nobuaki
N
Division of Nephrology and Endcrinology, Department of Internal Medicine, University of Tokyo.
Fukumoto
Seiji
S
D000818:Animals; D001847:Bone Diseases / Q000209:etiology; D001842:Bone and Bones / Q000378:metabolism*; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000502:physiology*; D006801:Humans; D051379:Mice
C000717427:FGF23 protein, human; C000717428:Fgf23 protein, mouse; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23