Anti-inflammatory activity of a new sphingosine derivative and cembrenoid diterpene (lobohedleolide) isolated from marine soft corals of Sinularia crassa TIXIER-DURIVAULT and Lobophytum species of the Andaman and Nicobar Islands.
The aim of this study is to determine the anti-inflammatory activity of a new sphingosine derivative (1) and cembrenoid diterpene (lobohedleolide) (2) isolated from the soft corals of Sinularia crassa and Lobophytum species respectively, collected on the coasts of Andaman and Nicobar Islands. The anti-inflammatory activity was evaluated using carrageenin-induced rat hind paw edema model for acute inflammation and cotton pellet granuloma model for chronic inflammation. Indomethacin was used as a standard drug in this study. Both the sphingosine derivative (1) and the cembrenoid diterpene (2) produced the maximum effect at a dose of 10 mg/kg and this is comparable to that of indomethacin (2 mg/kg, p<0.001). The observed anti-inflammatory activity is almost identical in both the types of experimental inflammation.
Medicinal Chemistry Divisions, University College of Pharmaceutical Sciences, Andhra University, Andhra Pradesh, India. radhika_parvataneni_in@yahoo.com
Parvataneni
P
Radhika
Pragada Rajeswara
PR
Rao
Jorige
J
Archana
Koteswara Rao
KR
Nalamolu
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001643:Bridged Bicyclo Compounds / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D005663:Furans / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013045:Species Specificity; D013057:Spectrum Analysis / Q000379:methods
D000893:Anti-Inflammatory Agents; D001643:Bridged Bicyclo Compounds; D005663:Furans; C409627:lobohedleolide