Palliative radiotherapy with electrons of appendicular osteosarcoma in 54 dogs.
Radiotherapy is effective for the palliation of pain associated with primary and metastatic bony neoplasia in dogs and humans, but no standard treatment protocol has been established. The goal of this study was to evaluate a 3 x 8 Gy and a 4 x 6 Gy protocol using electrons with a betatron or linear accelerator for the treatment of appendicular osteosarcoma in 54 dogs. Thirty-three dogs received chemotherapy consisting of carboplatin IV concurrently with radiotherapy. Eighty-three % (n = 45) of the dogs experienced pain relief during or following treatment. The median duration of pain relief from treatment start was 53 days. In conclusion, both protocols are effective for palliation of clinical signs of canine appendicular osteosarcoma. The outcome reported here is similar to the results of other studies using Co photons. The use of chemotherapy did not improve the response to radiotherapy.
Section of Diagnostic Imaging and Radiation Oncology, Vetsuisse Faculty, University of Zürich, Switzerland. fmueller@vetclinics.unizh.ch
Fabienne
F
Mueller
Valerie
V
Poirier
Katja
K
Melzer
Dagmar
D
Nitzl
Malgorzata
M
Roos
Barbara
B
Kaser-Hotz
D000818:Animals; D000970:Antineoplastic Agents; D001859:Bone Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D016190:Carboplatin / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D004285:Dogs; D004583:Electrons / Q000627:therapeutic use*; D005260:Female; D007275:Injections, Intravenous; D008136:Longevity / Q000528:radiation effects; D008297:Male; D012516:Osteosarcoma / Q000401:mortality / Q000556:secondary / Q000628:therapy / Q000662:veterinary*; D059408:Pain Management; D010166:Palliative Care; D018714:Radiotherapy, Adjuvant / Q000662:veterinary; D015996:Survival Rate; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D016190:Carboplatin