Predictors of endothelial dysfunction in young women with polycystic ovary syndrome.
BACKGROUND
Women with polycystic ovary syndrome (PCOS) may be at increased risk for cardiovascular disease. Endothelial dysfunction is an early marker of atherosclerosis.


OBJECTIVE
The objectives of this study were to 1) compare endothelial function in young women with PCOS and regularly menstruating control women, and 2) to identify the determinants of endothelial function and investigate its relationship with body mass index in women with PCOS.


METHODS
This was a cross-sectional study.


METHODS
This study was conducted at a tertiary cardiovascular research center.


METHODS
Sixty-two young women with PCOS (mean age, 22.7 yr) and 17 control women, matched as a group for age and body mass index, were studied. Twenty-three women with PCOS were lean, 21 were overweight, and 18 were obese.


METHODS
Endothelium-dependent and -independent vascular function was assessed by measuring flow-mediated dilation (FMD) and nitrate-mediated dilation in the brachial artery (diameter change during hand hyperemia and after sublingual glyceryl trinitrate administration, respectively).


RESULTS
FMD and nitrate-mediated dilation were significantly lower in PCOS than in control women (reduced by approximately 50 and 25%, respectively; both P < 0.0005). Insulin resistance, total testosterone, and total cholesterol were independent predictors of FMD, accounting for 21, 10, and 9% of the variance, respectively (P < 0.005 for all). A trend of deterioration in FMD from lean to overweight and obese PCOS women was observed, but differences among groups were not statistically significant.


CONCLUSIONS
Women with PCOS have significant endothelial dysfunction at an early age (i.e. early 20s), and largely independent of obesity. This suggests that women with PCOS are at increased risk for early onset cardiovascular disease and may gain particular benefit from measures to improve endothelial function.
Kravariti
Maria
M
F.R.C.P, Department of Endocrinology, University of Ioannina, Panepistimiou Avenue, 45 110 Ioannina, Greece.
Naka
Katerina K
KK
Kalantaridou
Sophia N
SN
Kazakos
Nikolaos
N
Katsouras
Christos S
CS
Makrigiannakis
Antonis
A
Paraskevaidis
Evangelos A
EA
Chrousos
George P
GP
Tsatsoulis
Agathocles
A
Michalis
Lampros K
LK
D000328:Adult; D015992:Body Mass Index; D001916:Brachial Artery / Q000503:physiopathology; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D009566:Nitrates; D009765:Obesity / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D011237:Predictive Value of Tests; D012039:Regional Blood Flow; D013739:Testosterone / Q000097:blood; D014664:Vasodilation
D009566:Nitrates; D013739:Testosterone; D002784:Cholesterol