Neurotrophins in murine viscera: a dynamic pattern from birth to adulthood.
There is growing evidence that target-derived neurotrophins regulate the function of visceral neurons after birth. However, the postnatal profile of neurotrophin supply from internal organs is poorly described. In this study, we compared neurotrophin concentrations in lysates of murine peripheral target tissues (lung, heart, liver, colon, spleen, thymus, kidney and urinary bladder) at different time points after birth. In most organs, there was a decrease of neurotrophin concentrations in the first weeks after birth. In contrast, there were characteristic increases of specific neurotrophins during adolescence or adulthood. These increases were found for nerve growth factor (NGF) in the heart, thymus, kidney and liver, for brain-derived neurotrophic factor (BDNF) in the lung, and for neurotrophin-3 (NT-3) in the colon. In conclusion, we show that neurotrophins display a very differential and dynamic profile in internal organs after birth.
Lommatzsch
Marek
M
Department of Pneumology, University of Rostock, 18057 Rostock, Germany. marek.lommatzsch@med.uni-rostock.de
Quarcoo
David
D
Schulte-Herbrüggen
Olaf
O
Weber
Heike
H
Virchow
Johann Christian
JC
Renz
Harald
H
Braun
Armin
A
D000375:Aging / Q000378:metabolism*; D000818:Animals; D017776:Autonomic Pathways / Q000254:growth & development* / Q000378:metabolism; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D003106:Colon / Q000378:metabolism; D015536:Down-Regulation / Q000502:physiology; D005260:Female; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D009206:Myocardium / Q000378:metabolism; D020932:Nerve Growth Factor / Q000378:metabolism; D009414:Nerve Growth Factors / Q000378:metabolism*; D020933:Neurotrophin 3 / Q000378:metabolism; D013950:Thymus Gland / Q000378:metabolism; D015854:Up-Regulation / Q000502:physiology; D014781:Viscera / Q000254:growth & development* / Q000294:innervation
D019208:Brain-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D020933:Neurotrophin 3; D020932:Nerve Growth Factor