Highly stable phenanthridinium frameworks as a new class of tunable DNA binding agents with cytotoxic properties.
A new class of cytotoxic heteroaromatic cations is presented, based on the dihydro-imidazo-phenanthridinium framework (DIP), that have affinity for DNA and cytotoxicity toward cancerous cells. The DIP framework is particularly tunable due to the flexible synthetic methodology. Furthermore, the central moiety has proved to be very stable to hydrolysis and reduction compared to other phenanthridinium-based agents.
Department of Chemistry, The University of Glasgow, Joseph Black Building, UK.
Alexis D C
AD
Parenty
Louise V
LV
Smith
Kevin M
KM
Guthrie
De-Liang
DL
Long
Jane
J
Plumb
Robert
R
Brown
Leroy
L
Cronin
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004247:DNA / Q000378:metabolism*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D007364:Intercalating Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010617:Phenanthridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D007093:Imidazoles; D007364:Intercalating Agents; D010617:Phenanthridines; C014740:phenanthridinium; D004247:DNA