The effects of green tea ingestion over four weeks on atherosclerotic markers.
BACKGROUND
The objective of this study was to evaluate the effects of green tea ingestion over four weeks on atherosclerotic biological markers.


METHODS
After a one-week baseline period, 12 healthy male volunteers aged 28--42 years drank 600 mL of green tea daily for four weeks. Lipid profile, oxidized low-density lipoprotein (ox-LDL), total antioxidant capacity (TAC), C-reactive protein (CRP) and soluble cell adhesion molecules were measured at baseline and after two and four weeks ingestion of green tea.


RESULTS
There was no significant change in the concentrations of lipid profile, TAC, CRP, soluble intercellular adhesion molecule-1 (sICAM-1), or soluble E-selectin after ingestion of green tea. The levels of ox-LDL and soluble vascular cell adhesion molecule-1 (sVCAM-1) were significantly decreased after four weeks of green tea ingestion (Wilcoxon signed rank test, P=0.006).


CONCLUSIONS
The results of this study suggest an in vivo anti-oxidative effect for green tea and an influence of green tea on atherosclerotic biological markers. The effect of green tea seen on ox-LDL and sVCAM-1 provides a potential mechanism for the cardiovascular benefits of regular ingestion of green tea.
Department of Laboratory Medicine, Asan Medical Center and University of College of Medicine, 388-1 Pungnap-dong, Songpa-Gu, Seoul 138-736, South Korea.
Heungsup
H
Sung
Won-Ki
WK
Min
Woochang
W
Lee
Sail
S
Chun
Hyosoon
H
Park
Yong-Wha
YW
Lee
Seongsoo
S
Jang
Do-Hoon
DH
Lee
D000328:Adult; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D001161:Arteriosclerosis / Q000097:blood / Q000517:prevention & control*; D015415:Biomarkers / Q000097:blood*; D004032:Diet; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D013662:Tea / Q000737:chemistry*; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
D000975:Antioxidants; D015415:Biomarkers; D008077:Lipoproteins, LDL; D013662:Tea; D019010:Vascular Cell Adhesion Molecule-1; C099252:oxidized low density lipoprotein