The pituitary effects of GnRH.
Advances in our understanding of the complexity of GnRH actions at the pituitary and the various mechanisms involved in mediating differential LH and FSH biosynthesis and secretion at the gonadotrope, are continually emerging. In this review, we summarise recent studies pertaining to GnRH and GnRH receptor phylogeny, the divergent signalling and trafficking pathways initiated and utilised by GnRH and its receptor, and the pathways that mediate gonadotropin secretion from the gonadotrope.
Pawson
Adam J
AJ
Human Reproductive Sciences Unit, Medical Research Council, The University of Edinburgh Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK.
McNeilly
Alan S
AS
D000818:Animals; D002118:Calcium / Q000378:metabolism; D005640:Follicle Stimulating Hormone / Q000096:biosynthesis / Q000378:metabolism; D007987:Gonadotropin-Releasing Hormone / Q000737:chemistry / Q000494:pharmacology* / Q000502:physiology; D006801:Humans; D007986:Luteinizing Hormone / Q000096:biosynthesis / Q000378:metabolism; D010802:Phylogeny; D010902:Pituitary Gland / Q000187:drug effects* / Q000502:physiology; D011966:Receptors, LHRH / Q000502:physiology; D015398:Signal Transduction
D011966:Receptors, LHRH; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002118:Calcium