Design in silico, synthesis and binding evaluation of a carbohydrate-based scaffold for structurally novel inhibitors of matrix metalloproteinases.
Fragai
Marco
M
Magnetic Resonance Center (CERM) and Department of Agricultural Biotechnology (DIBA), University of Florence, Via Sacconi 6, 50019 Sesto Fiorentino FI, Italy.
Nativi
Cristina
C
Richichi
Barbara
B
Venturi
Chiara
C
D001667:Binding, Competitive; D003198:Computer Simulation; D018360:Crystallography, X-Ray; D015195:Drug Design; D006020:Glycopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008024:Ligands; D053508:Matrix Metalloproteinase 12; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000737:chemistry*; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship
D006020:Glycopeptides; D008024:Ligands; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases; D008666:Metalloendopeptidases; D053508:Matrix Metalloproteinase 12