Myosin VI is required for normal retinal function.
Different unconventional myosins have been shown to play important roles in sensory function, including vision. We investigated the role of myosin VI by examining the retinas of mice carrying a null mutation in the myosin VI gene. Myosin VI was found to be present in the photoreceptor and RPE cells of normal retinas. In the absence of myosin VI, the amplitudes of the a- and b-waves of the electroretinogram were reduced, although there was not photoreceptor cell loss and retinal anatomy appeared normal. Our results indicate that myosin VI is required in photoreceptor cells for normal retinal electrophysiology.
Kitamoto
Junko
J
Department of Pharmacology, UCSD School of Medicine, La Jolla, CA 92093-0912, USA.
Libby
Richard T
RT
Gibbs
Daniel
D
Steel
Karen P
KP
Williams
David S
DS
D000818:Animals; D002478:Cells, Cultured; D004596:Electroretinography; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D018995:Myosin Heavy Chains / Q000235:genetics / Q000502:physiology*; D010857:Pigment Epithelium of Eye / Q000378:metabolism; D012160:Retina / Q000502:physiology*; D012374:Rod Cell Outer Segment / Q000378:metabolism
C089785:myosin VI; D018995:Myosin Heavy Chains