Salvinicins A and B, new neoclerodane diterpenes from Salvia divinorum.
[reaction: see text] Two new neoclerodane diterpenes, salvinicins A (4) and B (5), were isolated from the dried leaves of Salvia divinorum. The structures of these compounds were elucidated by spectroscopic techniques, including (1)H and (13)C NMR, NOESY, HMQC, and HMBC. The absolute stereochemistry of these compounds was assigned on the basis of single-crystal X-ray crystallographic analysis of salvinicin A (4) and a 3,4-dichlorobenzoate derivative of salvinorin B.
Harding
Wayne W
WW
Division of Medicinal & Natural Products Chemistry, The University of Iowa, Iowa City, 52242, USA.
Tidgewell
Kevin
K
Schmidt
Matthew
M
Shah
Kushal
K
Dersch
Christina M
CM
Snyder
John
J
Parrish
Damon
D
Deschamps
Jeffrey R
JR
Rothman
Richard B
RB
Prisinzano
Thomas E
TE
D018360:Crystallography, X-Ray; D004224:Diterpenes; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D009292:Narcotic Antagonists; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D027544:Salvia / Q000737:chemistry*
D004224:Diterpenes; D045785:Diterpenes, Clerodane; D009292:Narcotic Antagonists; C468586:neoclerodane; C509586:salvinicin A; C509587:salvinicin B