[Ocular side-effects associated with amiodarone therapy].
Amiodarone, one of the most effective anti-arrhythmic drugs, is also known for its ability to accumulate lipid-pharmakon complexes in the lysosomes of different tissues. In the eye the lysosomal storage leads to typical side-effects. Whorl-like epithelial, reversible corneal inclusions occur in about 70 to 100 % of the patients on amiodarone therapy. Tiny lens opacities without visual impairment have been reported in 50 % of patients who had been treated with amiodarone. At present the most severe complication of amiodarone is optic neuropathy with an incidence of 1.3 to 1.8 %. The optic neuropathy, as the rule, is only reversible approximately in (1/2) of the patients after discontinuing the drug. The fundoscopic picture of amiodarone neuropathy is similar to classic AION. Retinal involvement has also been reported; however, a relationship with amiodarone has not been proven yet.
Universitätsklinik und Poliklinik für Augenheilkunde, Martin-Luther-Universität Halle-Wittenberg. T_Gulay@yahoo.com
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Turdumambetova
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Bredehorn
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Duncker
D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D003318:Corneal Opacity / Q000139:chemically induced* / Q000175:diagnosis; D004305:Dose-Response Relationship, Drug; D005123:Eye / Q000187:drug effects*; D006801:Humans; D009901:Optic Nerve Diseases / Q000139:chemically induced* / Q000175:diagnosis; D012162:Retinal Degeneration / Q000139:chemically induced* / Q000175:diagnosis; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors
D000889:Anti-Arrhythmia Agents; D000638:Amiodarone