[Epileptic seizures during childbirth in a patient with idiopathic generalised epilepsy].
During her first pregnancy, a 37-year-old woman with idiopathic generalised epilepsy that was adequately controlled with lamotrigine experienced a series of epileptic seizures following an elective caesarean section. The attacks were terminated with diazepam. The following day, she developed EEG-confirmed status epilepticus, for which midazolam was administered intravenously. No further attacks were observed and the patient was later discharged in good condition with a healthy newborn son. She remained on lamotrigine therapy. At the end of her second pregnancy, the patient again experienced tonic-clonic seizures. The dosage of lamotrigine was increased and the patient received clonazepam intravenously, but a new seizure quickly occurred. Following an emergency caesarean section with midazolam treatment, a healthy daughter was born. No further attacks were observed. This case history illustrates the occurrence of adult idiopathic generalised epilepsy and highlights the problems that can arise late in pregnancy and during childbirth.
Voermans
N C
NC
Universitair Medisch Centrum St Radboud, afd. Neurologie, Postbus 9101, Nijmegen.
Zwarts
M J
MJ
Renier
W O
WO
Bloem
B R
BR
D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D002585:Cesarean Section; D002998:Clonazepam / Q000627:therapeutic use; D003975:Diazepam / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy*; D004829:Epilepsy, Generalized / Q000188:drug therapy; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D008874:Midazolam / Q000627:therapeutic use; D007744:Obstetric Labor Complications / Q000188:drug therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011256:Pregnancy Outcome; D014227:Triazines / Q000627:therapeutic use
D000927:Anticonvulsants; D014227:Triazines; D002998:Clonazepam; D003975:Diazepam; D008874:Midazolam; D000077213:Lamotrigine