Suppressive effects of dichloromethane fraction from the Areca catechu nut on naloxone-precipitated morphine withdrawal in mice.
In the present study, we investigated the effect of the dichloromethane fraction from Areca catechu nut on the severity of naloxone-precipitated morphine withdrawal in morphine-dependent mice. A single intraperitoneal injection of dichloromethane fraction at dose of 125 and 175 mg/kg significantly delayed the onset of withdrawal jumping behavior in a concentration-dependent manner compared to that of saline controls. The dichloromethane fractions also significantly decreased jumping numbers and faecal and urinary excretions during the withdrawal period.
Department of Physiology, Faculty of Science, Prince of Songkla University, Songkhla Province, Thailand. ekumarnsit@yahoo.com
Ekkasit
E
Kumarnsit
Niwat
N
Keawpradub
Uraporn
U
Vongvatcharanon
Kitja
K
Sawangjaroen
Piyarat
P
Govitrapong
D000701:Analgesics, Opioid / Q000009:adverse effects*; D000818:Animals; D001114:Areca; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D009020:Morphine / Q000009:adverse effects*; D009270:Naloxone; D009292:Narcotic Antagonists; D009754:Nuts; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013375:Substance Withdrawal Syndrome / Q000209:etiology / Q000517:prevention & control*
D000701:Analgesics, Opioid; D009292:Narcotic Antagonists; D010936:Plant Extracts; D009270:Naloxone; D009020:Morphine