Microwave-assisted intramolecular Suzuki-Miyaura reaction to macrocycle, a concise asymmetric total synthesis of biphenomycin B.
[reaction: see text] A concise and efficient total synthesis of biphenomycin B has been accomplished featuring a key microwave-assisted intramolecular Suzuki-Miyaura reaction for formation of the 15-membered meta,meta-cyclophane 20.
Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette, France.
Renaud
R
Lépine
Jieping
J
Zhu
D008872:Microwaves; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry
D010456:Peptides, Cyclic; C047537:biphenomycin B