Elevated expression of TARC (CCL17) and MDC (CCL22) in models of cigarette smoke-induced pulmonary inflammation.
TARC (CCL17) and MDC (CCL22) are well-known chemoattractants for Th2 cells. Here, we evaluated the role of both chemokines for cigarette smoke-induced airway inflammation. The expression profiles of MDC, TARC, and their receptor CCR4 were analyzed in models of acute and chronic cigarette smoke-induced airway inflammation that is characterized by a Th1 immune response. The results were compared to the expression of both chemokines in models of idiopathic pulmonary fibrosis and acute asthma, which are associated with a Th2 immune response. The expression of MDC and TARC was found to be elevated in all lung inflammation models. In contrast to the findings in the asthma and lung fibrosis models, the increased expression of MDC and TARC in the cigarette-smoke model was not associated with an increased infiltration of Th2 cells into smoke-treated lungs. Our data indicate that instead of Th2 cells, airway epithelial cells expressing CCR4 might be the principal targets for MDC and TARC released from alveolar macrophages during cigarette smoke-induced airway inflammation.
Department of Pulmonary Research, Boehringer Ingelheim Pharma GmbH & Co. KG, D-88937 Biberach a.d. Riss, Germany.
Mirko
M
Ritter
Rolf
R
Göggel
Nveed
N
Chaudhary
Alexander
A
Wiedenmann
Birgit
B
Jung
Andreas
A
Weith
Peter
P
Seither
D000534:Alum Compounds; D000818:Animals; D001249:Asthma / Q000209:etiology / Q000276:immunology; D001761:Bleomycin; D001980:Bronchi / Q000187:drug effects / Q000276:immunology*; D002478:Cells, Cultured; D054422:Chemokine CCL22; D019742:Chemokines, CC / Q000276:immunology*; D002908:Chronic Disease; D004195:Disease Models, Animal; D005355:Fibrosis / Q000209:etiology / Q000276:immunology; D005786:Gene Expression Regulation / Q000276:immunology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology*; D008297:Male; D011014:Pneumonia / Q000209:etiology* / Q000276:immunology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D020545:Respiratory Mucosa / Q000187:drug effects / Q000276:immunology*; D012907:Smoking / Q000009:adverse effects*; D013638:Tars / Q000633:toxicity
D000534:Alum Compounds; D054422:Chemokine CCL22; D019742:Chemokines, CC; D013638:Tars; C024746:tobacco tar; D001761:Bleomycin; C041524:aluminum sulfate