Magnetic micro- and nanoparticle mediated activation of mechanosensitive ion channels.
Most cells are known to respond to mechanical cues, which initiate biochemical signalling pathways and play a role in cell membrane electrodynamics. These cues can be transduced either via direct activation of mechanosensitive (MS) ion channels or through deformation of the cell membrane and cytoskeleton. Investigation of the function and role of these ion channels is a fertile area of research and studies aimed at characterizing and understanding the mechanoactive regions of these channels and how they interact with the cytoskeleton are fundamental to discovering the specific role that mechanical cues play in cells. In this review, we will focus on novel techniques, which use magnetic micro- and nanoparticles coupled to external applied magnetic fields for activating and investigating MS ion channels and cytoskeletal mechanics.
Institute of Science and Technology in Medicine, Keele University, Thornburrow Drive, Hartshill, Stoke-on-Trent, ST4 7QB, UK.
Steven
S
Hughes
Alicia J
AJ
El Haj
Jon
J
Dobson
D001696:Biomechanical Phenomena / Q000379:methods; D015640:Ion Channel Gating / Q000502:physiology* / Q000528:radiation effects; D007473:Ion Channels / Q000737:chemistry / Q000502:physiology* / Q000528:radiation effects; D008280:Magnetics; D008465:Mechanoreceptors / Q000737:chemistry / Q000502:physiology* / Q000528:radiation effects; D040542:Mechanotransduction, Cellular / Q000502:physiology* / Q000528:radiation effects; D008954:Models, Biological; D043942:Nanotubes; D010316:Particle Size; D010812:Physical Stimulation / Q000379:methods*; D013314:Stress, Mechanical; D013329:Structure-Activity Relationship
D007473:Ion Channels