New insights into serotonin 5-HT4 receptors : a novel therapeutic target for Alzheimer's disease?
The serotonin 5-HT4 receptor mediates many physiological effects in the central nervous system. The recent molecular identification of 5-HT4 receptors and the development of selective 5-HT4 receptor ligands have led to many important new insights into the signalling pathways and the physiological roles of these G protein-coupled-receptors in neurones. With respect to neurodegenerative disorders, it is suggested that 5-HT4 agonists may represent a new avenue for the treatment of Alzheimer's disease. This mini-review will focus on recent in vitro and in vivo pharmacological and biochemical studies showing the involvement of 5-HT4 receptors in cognitive processes and the amyloid precursor protein processing. The potential use of 5-HT4 agonists for the treatment of AD will be discussed.
Cardiologie Cellulaire et Moléculaire, Inserm U-446, Université de Paris XI, 92296 Châtenay-Malabry, France.
Marjorie
M
Maillet
Sylvain J
SJ
Robert
Frank
F
Lezoualc'h
D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism* / Q000523:psychology; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D003071:Cognition; D006801:Humans; D011499:Protein Processing, Post-Translational; D044422:Receptors, Serotonin, 5-HT4 / Q000378:metabolism*; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use*
D016564:Amyloid beta-Protein Precursor; D017366:Serotonin Receptor Agonists; D044422:Receptors, Serotonin, 5-HT4