Potential secondary pathogenic role for bovine herpesvirus 4.
Bovine herpesvirus 4 (BoHV-4) is a gammaherpesvirus with no clear disease association. Previous studies have demonstrated that macrophages can harbor persistent BoHV-4. We found that the addition of prostaglandin E2 (PGE2) to bovine macrophage cells persistently infected with BoHV-4 increases viral replication. Because opportunistic infection can increase PGE2 production, we propose a link between opportunistic infection, PGE2 production, and BoHV-4 replication.
Dipartimento di Salute Animale, Sezione di Malattie Infettive degli Animali, Facoltà di Medicina Veterinaria, via del Taglio 8, 43100 Parma, Italy. gaetano.donofrio@unipr.it
Gaetano
G
Donofrio
Sandro
S
Cavirani
Vicky
V
van Santen
Cesidio Filippo
CF
Flammini
D000818:Animals; D002417:Cattle; D045744:Cell Line, Tumor; D015232:Dinoprostone / Q000378:metabolism / Q000494:pharmacology*; D026021:Herpesvirus 4, Bovine / Q000472:pathogenicity* / Q000502:physiology; D017737:Macrophages, Peritoneal / Q000821:virology*; D017735:Virus Latency; D014779:Virus Replication / Q000187:drug effects*
D015232:Dinoprostone