The Oral Fluid MEMS/NEMS Chip (OFMNC): diagnostic and translational applications.
The ability to monitor health status, disease onset and progression, and treatment outcome through non-invasive means is a most desirable goal in health-care promotion and delivery. There are three prerequisites for this goal to be realized: specific biomarkers associated with a health or disease state, a non-invasive approach to detect and monitor the biomarkers, and the technologies to discriminate between and among the biomarkers. We present a roadmap to achieve these goals using oral fluids as the diagnostic medium to scrutinize the health and/or disease status of individuals. This is an ideal opportunity to bridge state-of-the-art micro-/nano-electromechanical system (MEMS/NEMS) sensors to oral fluid for diagnostic applications. As the "mirror of body", oral fluid is a perfect medium to be explored for health and disease surveillance. The translational applications and opportunities are enormous.
University of California, Los Angeles, School of Dentistry and Dental Research Institute, 73-017 CHS, 10833 Le Conte Ave, Los Angeles, CA 90095, USA.
Y
Y
Li
P
P
Denny
C-M
CM
Ho
C
C
Montemagno
W
W
Shi
F
F
Qi
B
B
Wu
L
L
Wolinsky
D T
DT
Wong
D015415:Biomarkers; D015374:Biosensing Techniques; D003945:Diagnosis, Oral / Q000379:methods*; D006801:Humans; D046208:Microchip Analytical Procedures; D036103:Nanotechnology; D014176:Protein Biosynthesis; D040901:Proteomics; D012313:RNA / Q000032:analysis; D012463:Saliva / Q000737:chemistry* / Q000378:metabolism; D012471:Salivary Proteins and Peptides / Q000032:analysis* / Q000096:biosynthesis
D015415:Biomarkers; D012471:Salivary Proteins and Peptides; D012313:RNA