Differential effects of clozapine and haloperidol on interval timing in the supraseconds range.
The effects of clozapine (0.6, 1.2, and 2.4 mg/kg) and haloperidol (0.03, 0.06, and 0.12 mg/kg) on the timing of 10, 30, and 90-s intervals were characterized in rats. Each drug's effect on timing behavior was assessed following intraperitoneal injections using a variant of the peak-interval procedure. Although haloperidol proportionately shifted peak times rightward in a manner consistent with a decrease in clock speed, clozapine exerted the opposite effect and proportionately shifted peak times leftward in a manner consistent with an increase in clock speed. These results support the proposal that typical antipsychotic drugs such as haloperidol and atypical antipsychotic drugs such as clozapine exert differential effects on dopaminergic, serotonergic, and glutamatergic systems within the cortex and striatum, two brain regions shown to be crucial for interval timing.
Department of Psychological and Brain Sciences, Duke University, Genome Sciences Research Building II, 3rd Floor, P.O. Box 91050, Durham, NC 27708, USA.
Christopher J
CJ
MacDonald
Warren H
WH
Meck
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D003024:Clozapine / Q000494:pharmacology*; D004298:Dopamine / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D018698:Glutamic Acid / Q000502:physiology; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D017397:Prefrontal Cortex / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000502:physiology; D013998:Time Perception / Q000187:drug effects*
D014150:Antipsychotic Agents; D012701:Serotonin; D018698:Glutamic Acid; D003024:Clozapine; D006220:Haloperidol; D004298:Dopamine