Thymoma and hypogammaglobulinemia (Good's syndrome): a case report.
Good's syndrome is extremely rare and refers to an acquired B and T cell immunodeficiency in thymoma patients. We report a 51-year-old female thymoma patient who presented with recurrent herpes zoster, pneumonia, diarrhea and opportunistic infections. She was found to have acquired hypogammaglobulinemia with absent B cells. Despite repeat intravenous immunoglobulin replacement and antibiotic therapy, she died of bacterial pneumonia-induced acute respiratory distress syndrome. Clinicians should look for evidence of immunologic dysfunction in thymoma patients presenting with recurrent infections.
Department of Pediatrics, Christian Hospital, Institute of Medical Research, Chang Jung Christian University, Changhua, Taiwan.
Yi-Giien
YG
Tsai
Jenn-Haung
JH
Lai
San-Yuan
SY
Kuo
Hsiang-Cheng
HC
Chen
Deh-Ming
DM
Chang
D000361:Agammaglobulinemia / Q000150:complications*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008875:Middle Aged; D013945:Thymoma / Q000150:complications*; D013953:Thymus Neoplasms / Q000150:complications*