Can regurgitant flow damage the left atrial endothelium in patients with prosthetic mechanical heart valves?
OBJECTIVE
Previous in-vitro studies of mechanical heart valves (MHVs) in the closed position demonstrated the formation of regurgitant flows, with bubbles and jets forming vortices during each systole. The study aim was to determine whether the regurgitant flow observed in patients with MHVs can damage the left atrial endothelium, due to shear stresses exerted on the endothelial layers. This objective has been accomplished by appropriate in-vitro simulation experiments.


METHODS
In these experiments, leakage flow through several commercial MHVs was investigated. The geometry of the set-up closely resembled that of the left atrial anatomy. Water was forced through the slit of a closed MHV and directed toward the hemispherical cup coated with fluorescent paint. The flow field between the valve and the cup was photographed using high-speed videography, from which local velocities were measured, using digital particle imaging velocimetry. Qualitative damage to the surface of the cup was assessed from the amount of fluorescent paint removed from the cup.


RESULTS
The experimental results and calculations indicated that flows through the gaps of the closed valves were sufficient to generate strong vortices, with velocities near the atrial wall in the range of 0.5 to 4.0 m/s, depending on the valve. This led to high shear stresses on the left atrial wall, which far exceeded physiologically acceptable levels.


CONCLUSIONS
The calculated shear stresses exceeded by orders of magnitude the maximum physiologically tolerated stresses. This suggests that shear stresses associated with regurgitant jets in MHVs may damage the endothelial cells, leading to the activation of the inflammatory reaction, enhanced procoagulation, platelet activation and aggregation, and mechanical cell denudation.
Milo
Simcha
S
Faculty of Medicine, Department of Cardiac Surgery, Rambam Medical Center, Technion--Institute of Technology, Haifa, Israel. smilo@rambam.health.gov.il
Zarandi
Mehrdad
M
Gutfinger
Chaim
C
Gharib
Morteza
M
D000465:Algorithms; D001696:Biomechanical Phenomena; D001783:Blood Flow Velocity / Q000502:physiology; D001790:Blood Physiological Phenomena; D004730:Endothelium, Vascular / Q000033:anatomy & histology*; D045268:Flowmeters; D005456:Fluorescent Dyes; D006325:Heart Atria / Q000033:anatomy & histology*; D006350:Heart Valve Prosthesis / Q000009:adverse effects; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008953:Models, Anatomic; D009040:Motion Pictures; D011474:Prosthesis Design; D012212:Rheology; D013314:Stress, Mechanical; D013599:Systole / Q000502:physiology
D005456:Fluorescent Dyes