[Mechanisms of epigenetic reprogramming in Mammalian resonstructed embryos produced by nuclear transfer.].
Circumstantial studies indicated that incomplete or inappropriate epigenetic reprogramming of donor nuclei was likely to be the primary reason for failures in nuclear transfer. In this view, we discussed the roles of several epigenetic mechanisms, including DNA methylation, chromatin remodeling, imprinting and X chromosome inactivation, telomere maintenance, and epigenetic inheritance in the observed abnormalities in clones from different species. Understanding the mechanisms underlying epigenetic reprogramming control will help us resolve the inherent problems in nuclear transfer technology and make its applications promising.
College of Animal Science, Nanjing Agricultural University, Nanjing 210095, China, Email: sushijing@263.net.
Shi-Jing
SJ
Xu
Yin-Xue
YX
Xu
Hong-Lin
HL
Liu
D021581:Active Transport, Cell Nucleus; D000818:Animals; D065150:Cellular Reprogramming; D019976:Cloning, Organism; D019175:DNA Methylation; D004622:Embryo, Mammalian; D044127:Epigenesis, Genetic; D053652:Nuclear Transfer Techniques