Prefrontal cortical cells projecting to the supplementary eye field and presupplementary motor area in the monkey.
We examined the location and spatial distribution of prefrontal cortical (PF) cells projecting to the supplementary eye field (SEF) and presupplementary motor area (pre-SMA) using a double retrograde-labeling technique in monkeys (Macaca fuscata). The SEF and pre-SMA were physiologically identified based on the findings of intracortical microstimulation and single cell recordings. Two fluorescent tracers, diamidino yellow and fast blue, were injected into the SEF and pre-SMA of each monkey. Retrogradely labeled cells in the PF were plotted with an automated plotting system. The cells projecting to the SEF and pre-SMA were mainly distributed in the upper and lower banks of the principal sulcus (area 46), with little overlap. Cells projecting to the SEF, but not to the pre-SMA, were observed in areas 8a, 8b, 9, 12, and 45. These findings suggest that the SEF and pre-SMA receive different sets of information from the PF cells.
Department of Physiology, School of Medicine, Tohoku University, Sendai 980-8575, Japan.
Yan
Y
Wang
Masaki
M
Isoda
Yoshiya
Y
Matsuzaka
Keisetsu
K
Shima
Jun
J
Tanji
D000200:Action Potentials / Q000502:physiology / Q000528:radiation effects; D000578:Amidines / Q000378:metabolism; D000818:Animals; D001931:Brain Mapping; D004558:Electric Stimulation / Q000379:methods; D005133:Eye Movements / Q000502:physiology*; D008252:Macaca fascicularis; D009044:Motor Cortex / Q000166:cytology* / Q000502:physiology; D009434:Neural Pathways / Q000166:cytology* / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D017397:Prefrontal Cortex / Q000033:anatomy & histology* / Q000502:physiology; D018709:Statistics, Nonparametric
D000578:Amidines; C031455:diamidino compound 253-50; C037945:diamidino yellow