Reactions of enamines with selectfluor: a straightforward route to difluorinated carbonyl compounds.
[reaction: see text] Reactions of enamines, preformed from beta-dicarbonyl and monocarbonyl compounds, with Selectfluor (1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) under mild conditions (triethylamine (TEA) or molecular sieves) easily led to the corresponding difluorinated carbonyl compounds in high yields.
Department of Chemistry, University of Idaho, Moscow, Idaho 83844-2343, USA.
Weimin
W
Peng
Jean'ne M
JM
Shreeve