Relation of C-reactive protein to insulin resistance and cardiovascular risk factors in youth.
OBJECTIVE
Insulin resistance and C-reactive protein (CRP) levels are strongly correlated in adults. This study explored the relationship in youth.


METHODS
Associations between CRP levels, cardiovascular risk, and insulin resistance measured by the euglycemic clamp were investigated in 342 healthy Minneapolis youth.


RESULTS
There was no difference in mean CRP levels among boys (n = 189, CRP 1.10 +/- 0.46 mg/l) and girls (n = 153, CRP 1.16 +/- 0.63 mg/l; P = 0.32). There was also no difference between CRP and Tanner stage. CRP, adjusted for BMI, was significantly greater in black subjects compared with white subjects (P = 0.03). CRP was strongly related to adiposity in both girls and boys. CRP levels were related to fasting insulin levels (r = 0.16, P = 0.003) but this association was not significant after adjustment for BMI (r = 0.07, P = 0.21). Similarly, M, the euglycemic clamp measurement of insulin sensitivity, was significantly related to CRP levels (r = -0.13, P = 0.02) but not when M was normalized to lean body mass (M(lbm)) (r = -0.10, P = 0.09). There was a significant inverse correlation between M(lbm) and CRP quartiles, which disappeared after adjustment for BMI. There was no significant association between CRP levels and lipids, blood pressure, physical activity, or left ventricular mass.


CONCLUSIONS
In contrast to adult subjects, after adjustment for adiposity, CRP levels in children age 10-16 years were not significantly associated with insulin resistance or with other factors comprising the metabolic syndrome. This is consistent with the concept that insulin resistance may precede the development of CRP elevation in the evolution of the metabolic syndrome.
Deprtment of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA. moran001@umn.edu
Antoinette
A
Moran
Lyn M
LM
Steffen
David R
DR
Jacobs
Julia
J
Steinberger
James S
JS
Pankow
Ching-Ping
CP
Hong
Russell P
RP
Tracy
Alan R
AR
Sinaiko
D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D002648:Child; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood; D044469:Racial Groups; D012307:Risk Factors
D015415:Biomarkers; D002097:C-Reactive Protein