Apoptolidins B and C: isolation, structure determination, and biological activity.
[reaction: see text] Apoptolidin (1) is a promising new therapeutic lead that exhibits remarkable selectivity against cancer cells relative to normal cells. We report the isolation, characterization, solution structure, stability, and biological activity of two new members of this family: apoptolidins B (2) and C (3). These new agents are found to have antiproliferative activity on par with or better than apoptolidin itself in an assay with H292 lung cancer cells.
Department of Chemistry, Stanford University, California 94305-5080, USA. wenderp@stanford.edu
Paul A
PA
Wender
Martin
M
Sukopp
Kate
K
Longcore
D039903:Actinobacteria / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D018942:Macrolides; D011753:Pyrones; C506738:apoptolidin A; C509784:apoptolidin B; C509786:apoptolidin C