Subtype C Is associated with increased vaginal shedding of HIV-1.
The prevalence of human immunodeficiency virus (HIV)-1-infected cells and HIV-1 RNA levels in genital secretions and breast milk and the risk of mother-to-child transmission of HIV-1 were compared among subtypes A, C, and D in a Kenyan cohort. Pregnant women infected with subtype C were significantly more likely to shed HIV-1-infected vaginal cells than were those infected with subtype A or D (odds ratio [OR], 3.6 [95% confidence interval {CI}, 1.4-8.8]; P = .006). This relationship held after adjusting for age, CD4 cell count, and plasma HIV-1 RNA load (OR, 3.1 [95% CI, 1.1-8.6]; P = .03). These observations suggest that HIV-1 subtype influences mucosal shedding of HIV-1.
Department of Medicine, University of Washington, Seattle, 98104, USA. gjohn@u.washington.edu
Grace C
GC
John-Stewart
Ruth W
RW
Nduati
Christine M
CM
Rousseau
Dorothy A
DA
Mbori-Ngacha
Barbra A
BA
Richardson
Stephanie
S
Rainwater
Dana D
DD
Panteleeff
Julie
J
Overbaugh
D003126:Colostrum / Q000821:virology*; D005260:Female; D006679:HIV Seropositivity / Q000635:transmission*; D015497:HIV-1 / Q000145:classification / Q000302:isolation & purification*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D010802:Phylogeny; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D012367:RNA, Viral / Q000097:blood; D014621:Vagina / Q000821:virology*; D019562:Viral Load; D017201:Virus Shedding
D012367:RNA, Viral