Osteomalacia due to chemotherapy-induced Fanconi syndrome in an adult patient.
BACKGROUND
Chemotherapy-induced Fanconi syndrome is a dangerous condition that could lead to severe electrolyte disturbances and rarely to osteomalacia.


METHODS
A patient treated with ifosfamide for a metastatic cervix squamous-cell carcinoma was admitted for diffuse, symmetric bilateral pain in bones and articulations. The diagnosis work-up revealed that she suffered from osteomalacia due to a chemotherapy-induced Fanconi syndrome. The patient recovered completely with oral calcitriol supplements.


CONCLUSIONS
This very rare chemotherapy-complication suggests that detection of potential tubular dysfunction, by regular serum electrolyte monitoring of patients receiving ifosfamide, may be a reasonable approach to diagnose early chemotherapy-induced Fanconi syndrome, even in adults.
Duck
Lionel
L
Medical Oncology Unit, Centre du Cancer, Cliniques Universitaires St-Luc, Av. Hippocrate 10, 1200 Brussels, Belgium.
Devogelaer
Jean-Pierre
JP
Persu
Alexandre
A
Berlière
Martine
M
Caussin
Emmanuelle
E
Baurain
Jean-François
JF
Machiels
Jean-Pascal
JP
D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D005198:Fanconi Syndrome / Q000139:chemically induced / Q000150:complications*; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged; D010018:Osteomalacia / Q000209:etiology*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy
D007069:Ifosfamide