The effect of exogenous zinc ions on the pattern of oxygen consumption of the hepatic mitochondria of albino rats.
The effect of incubation of coupled liver mitochondria on varying concentration of zinc ion was determined. A low concentration of 6 microM zinc ion was found to inhibit the rate of oxygen consumption of the liver mitochondria significantly [P < 0.01]. There was uncoupling of the liver mitochondria when subjected to varying incubation periods. There was no change observed in the control experiment. Zinc-citrate inhibited the rate of oxygen consumption significantly [P < 0.01] when compare with the control. The changes observed in the Zn-aspartate were insignificant. Zn-EDTA had no inhibitory or stimulatory effect on the rate of liver mitochondrial oxygen consumption.
OCBC/Molecular Cell Biology, University of Maryland, Baltimore, Dental School, USA.
B I
BI
Kukoyi
L C
LC
Costello
R B
RB
Franklin
D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D015032:Zinc / Q000494:pharmacology*
D015032:Zinc