Serum lipids as protective factors for subarachnoid hemorrhage.
Identification of common serum lipid profiles in patients with subarachnoid hemorrhage (SAH) may allow a better understanding of its pathogenesis. We conducted a hospital-based case-control study in Japan. One hundred and fifty consecutive cases of spontaneous SAH during a 5-year period were examined and their lipid profiles assessed. Age- and gender-matched controls were identified for each case through random hospital sampling. Median serum total cholesterol was 161 mg/dl (range 77-288) in patients with SAH, and 209 mg/dl (134-441) in controls (p < 0.001). Median serum triglycerides were 95 mg/dl (range 28-589) in SAH and 122 mg/dl (31-371) in controls (p < 0.001). A high serum total cholesterol of more than 5.20 mmol/L (200 mg/dl) (odds ratio 0.22 [95% confidence interval 0.12-0.40]) and a high serum triglyceride of more than 1.70 mmol/L (150 mg/dl) (odds ratio 0.29 [95% CI 0.14-0.60]) were independent protective factors for SAH. In conclusion, higher values of both serum cholesterol and triglyceride may be inversely associated with the occurrence of SAH.
Department of Medicine, Okinawa Chubu Hospital, Okinawa, Japan and Harvard School of Public Health, Boston, USA. tokuyasu@orange.ocn.ne.jp
Yasuharu
Y
Tokuda
Gerald H
GH
Stein
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015984:Causality; D002784:Cholesterol / Q000097:blood; D015897:Comorbidity; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology*; D006949:Hyperlipidemias / Q000453:epidemiology*; D006973:Hypertension / Q000453:epidemiology; D007564:Japan / Q000453:epidemiology; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects; D013345:Subarachnoid Hemorrhage / Q000097:blood* / Q000453:epidemiology*; D014280:Triglycerides / Q000097:blood
D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol