Commercialization of plant-based vaccines from research and development to manufacturing.
The benefits of using plant-based oral vaccines are discussed. Transgenic maize expressing an antigen of transmissible gastroenteritis virus (TGEV) is reported as a model to demonstrate efficacy. Young pigs that were fed the TGEV corn orally were protected against challenge with virulent TGEV. Additional parameters important in providing a reliable and consistent supply of plant-based vaccines are discussed. Finally, vaccines developed in maize are evaluated for their potential to contaminate either the food supply or the environment.
Biotechnology Institute, 5819 Stallion Ridge, College Station, TX 77845, USA. jhoward999@appliedbiotech.org
John A
JA
Howard
D000818:Animals; D003132:Commerce; D005761:Gastroenteritis, Transmissible, of Swine / Q000517:prevention & control*; D008517:Phytotherapy; D012107:Research Design; D013552:Swine; D005760:Transmissible gastroenteritis virus / Q000276:immunology*; D014481:United States; D014611:Vaccination / Q000662:veterinary*; D014765:Viral Vaccines; D003313:Zea mays
D014765:Viral Vaccines