Utility of echocardiographic radial strain imaging to quantify left ventricular dyssynchrony and predict acute response to cardiac resynchronization therapy.
Echocardiographic strain imaging was used to quantify radial mechanical dyssynchrony in 38 patients who underwent cardiac resynchronization therapy. Dyssynchrony, defined as the time difference of peak radial strain in the septum versus the posterior wall, was significantly greater in patients with acute hemodynamic responses, and changes in radial dyssynchrony correlated with changes in stroke volume. A > or =130-ms difference in septal versus posterior wall peak strain when combined with a favorable left ventricular lead position was strongly predictive of immediate improvement in stroke volume with resynchronization therapy (95% sensitivity, 88% specificity), regardless of electrocardiographic QRS duration.
Dohi
Kaoru
K
University of Pittsburgh, Pennsylvania, USA.
Suffoletto
Matthew S
MS
Schwartzman
David
D
Ganz
Leonard
L
Pinsky
Michael R
MR
Gorcsan
John
J
D000368:Aged; D001145:Arrhythmias, Cardiac / Q000628:therapy; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006346:Heart Septum / Q000000981:diagnostic imaging / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial; D011237:Predictive Value of Tests; D011379:Prognosis; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*