Microinjections of nociceptin into the nucleus ambiguus elicit tachycardia in the rat.
Cardiovascular effects of activation of opioid receptor like receptors (ORL1 receptors) in the nucleus ambiguus were studied in urethane-anesthetized, adult male Wistar rats. Microinjections of nociceptin (0.31, 0.62, 1.25 and 2.25 mmol/L) into the nucleus ambiguus elicited increases in heart rate (17.5 +/- 4, 33.3 +/- 2.9, 16.5 +/- 1.5 and 13.9 +/- 2.7 beats/min, respectively) which were blocked by an ORL1 receptor antagonist. These results indicate that activation of ORL1 receptors in the nucleus ambiguus elicits tachycardia.
Department of Neurological Surgery, MSB H-586, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA.
Vineet C
VC
Chitravanshi
Hreday N
HN
Sapru
D000818:Animals; D018846:Excitatory Amino Acids / Q000819:agonists; D008297:Male; D008526:Medulla Oblongata / Q000166:cytology / Q000187:drug effects*; D008845:Microinjections; D009474:Neurons / Q000187:drug effects; D018847:Opioid Peptides / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D011957:Receptors, Opioid / Q000819:agonists* / Q000187:drug effects; D013610:Tachycardia / Q000139:chemically induced*; D000094942:Nociceptin Receptor; D000097629:Nociceptin
D018846:Excitatory Amino Acids; D018847:Opioid Peptides; D011957:Receptors, Opioid; D000094942:Nociceptin Receptor; D000097629:Nociceptin; C000722285:Oprl1 protein, rat