[Lipid peroxidation and anti-oxidative protection in patients with chronic type C hepatitis].
The aim of the work was to study lipid peroxidation (LP) activity and antioxidation protection sufficiency in patients with HCV lesion of the liver. The subjects of the study were 238 such patients, divided into groups according to the degree of the pathological process severity. The results demonstrate a significant increase of malonic dialdehyde (MDA) serum concentration (up to 143.75%) and simultaneous decrease of catalase serum concentration in patients with minimal activity of HCV chronic hepatitis (CH). In patients with moderate and high activity of the pathological process MDA serum concentrations were 150 and 175%, respectively; catalase activity decreased down to 64.8 and 58.47%, respectively. Hepatocirrhosis in HCV patients (HCV-H) was characterized by a more pronounced LP product accumulation and decrease of serum catalase activity. MDA serum concentration in patients with mixed viral CH and hepatocirrhosis was lower than in patients with HCV-H.
Mansurova
F Kh
FKh
Mutikhova
Kh Sh
KhSh
Olimova
S O
SO
D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D002374:Catalase / Q000097:blood; D019698:Hepatitis C, Chronic / Q000097:blood*; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D012720:Severity of Illness Index
D000975:Antioxidants; D015415:Biomarkers; D008315:Malondialdehyde; D002374:Catalase