Serum glucose concentration and ACP1 genotype in healthy adult subjects.
Acid phosphatase locus 1 (ACP 1 ) or cytosolic low molecular weight protein tyrosine phosphatase is a polymorphic enzyme that can hydrolyze phosphotyrosine-containing peptides of the human insulin receptor and of band 3 protein. High-activity ACP 1 may favor an increase in serum glucose concentration through a depression of insulin action and through inactivation of aldolase, phosphofructokinase, and glyceraldehyde-3-phosphate dehydrogenase induced by dephosphorylation of band 3 protein. In diabetic subjects, we have previously reported lower serum glucose concentration in subjects with low-activity ACP 1 A and AB phenotypes. We have now studied the relationship between serum glucose concentration and ACP 1 genotype in a sample of 137 healthy adult workers of our university. In males, serum glucose concentration is significantly higher in medium-high- than in low-activity ACP 1 genotypes. With advancing age in males, there is a progressive increase in glycemic differential between medium-high- and low-activity ACP 1 genotypes. The data suggest that normal variability of ACP 1 genotype influences serum glucose concentration in normal individuals. Such influence depends on sex and in males becomes more marked with advancing age.
Division of Occupational Health Medicine, Department of Biopathology and Imaging Diagnostics, School of Medicine, University of Rome Tor Vergata, 00123 Rome Italy.
Umberto
U
Iannaccone
Antonio
A
Bergamaschi
A
A
Magrini
Giuseppe
G
Marino
Nunzio
N
Bottini
Paola
P
Lucarelli
Egidio
E
Bottini
Fulvia
F
Gloria-Bottini
D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D005260:Female; D005634:Fructose-Bisphosphate Aldolase / Q000037:antagonists & inhibitors; D005838:Genotype; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000037:antagonists & inhibitors; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D008297:Male; D010732:Phosphofructokinase-1 / Q000037:antagonists & inhibitors; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D012016:Reference Values
D001786:Blood Glucose; D007527:Isoenzymes; D011518:Proto-Oncogene Proteins; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D010732:Phosphofructokinase-1; C068652:1-phosphofructokinase; C490429:ACP1 protein, human; D017027:Protein Tyrosine Phosphatases; D005634:Fructose-Bisphosphate Aldolase