Stem cell grand SLAM.
Stem cells in both embryonic and adult tissues are defined by their unique ability to balance self-renewal and differentiation such that mature cells necessary for tissue function can be generated and replaced without depletion of the stem cell pool. In this issue of Cell, report a major step forward for studying the mechanisms and regulation of such stem cell fate decisions in the blood-forming (hematopoietic) system by providing a simple and broadly applicable method to isolate these cells and to visualize them in their normal environment.
Wagers
Amy J
AJ
Joslin Diabetes Center, Boston, Massachusetts 02215, USA.
D000818:Animals; D015703:Antigens, CD; D015415:Biomarkers / Q000378:metabolism; D002454:Cell Differentiation / Q000276:immunology*; D019070:Cell Lineage / Q000276:immunology*; D049109:Cell Proliferation; D002469:Cell Separation / Q000379:methods; D042783:Endothelial Cells / Q000276:immunology; D006023:Glycoproteins / Q000276:immunology*; D006410:Hematopoiesis / Q000276:immunology*; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology*; D011956:Receptors, Cell Surface; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1
D015703:Antigens, CD; D015415:Biomarkers; D006023:Glycoproteins; D007136:Immunoglobulins; D011956:Receptors, Cell Surface; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1