Lethal, oedema, haemorrhagic activity of spotted butterfish (Scatophagus argus, Linn) sting extract and its neutralization by antiserum and pharmacological antagonists.
An attempt has been made in this communication to develop antiserum in rabbit against Scatophagus. argus sting extract. Antiserum did not neutralized the sting extract induced proinflammatory and haemorrhagic activity but successfully neutralized lethality upto 2LD50. Cyproheptadine, indomethacin and BW 755C pretreatment significantly reduced sting extract induced proinflammatory activity. The haemorrhagic activity of sting extract was significantly inhibited by temperature, UV-exposure, EDTA, cyproheptadine, indomethacin and BW 755C pretreatment. The results conclude that the local effects of S.argus venom is likely to be mediated through release of mediators and may be encountered by pharmacological antagonists better than the antiserum.
Laboratory of Toxinology and Experimental Pharmacodynamics, Department of Physiology, University of Calcutta, Kolkata 700 009, India.
D
D
Muhuri
S C
SC
Dasgupta
A
A
Gomes
D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine / Q000494:pharmacology; D000818:Animals; D003533:Cyproheptadine / Q000737:chemistry; D004487:Edema / Q000139:chemically induced / Q000473:pathology; D004492:Edetic Acid / Q000737:chemistry / Q000494:pharmacology; D005397:Fish Venoms / Q000737:chemistry* / Q000276:immunology / Q000494:pharmacology*; D006384:Hemagglutination; D006470:Hemorrhage / Q000139:chemically induced; D007106:Immune Sera / Q000737:chemistry*; D007213:Indomethacin / Q000494:pharmacology; D007249:Inflammation; D008297:Male; D051379:Mice; D010473:Perciformes; D011817:Rabbits; D051381:Rats; D013696:Temperature; D013997:Time Factors; D014466:Ultraviolet Rays
D005397:Fish Venoms; D007106:Immune Sera; D003533:Cyproheptadine; D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; D004492:Edetic Acid; D007213:Indomethacin