Simvastatin given for 3 days can inhibit thrombin generation and activation of factor V and enhance factor Va inactivation in hypercholesterolemic patients.
Undas
Anetta
A
Celinska-Löwenhoff
Magdalena
M
Brummel-Ziedins
Kathleen E
KE
Brozek
Jan
J
Szczeklik
Andrew
A
Mann
Kenneth G
KG
D001777:Blood Coagulation / Q000187:drug effects*; D005165:Factor V / Q000378:metabolism; D015943:Factor Va / Q000378:metabolism; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D019821:Simvastatin / Q000008:administration & dosage*; D013917:Thrombin / Q000378:metabolism
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D015943:Factor Va; D005165:Factor V; D019821:Simvastatin; D013917:Thrombin