New irradiation geometry for microbeam radiation therapy.
Microbeam radiation therapy (MRT) has the potential to treat infantile brain tumours when other kinds of radiotherapy would be excessively toxic to the developing normal brain. MRT uses extraordinarily high doses of x-rays but provides unusual resistance to radioneurotoxicity, presumably from the migration of endothelial cells from 'valleys' into 'peaks', i.e., into directly irradiated microslices of tissues. We present a novel irradiation geometry which results in a tolerable valley dose for the normal tissue and a decreased peak-to-valley dose ratio (PVDR) in the tumour area by applying an innovative cross-firing technique. We propose an MRT technique to orthogonally crossfire two arrays of parallel, nonintersecting, mutually interspersed microbeams that produces tumouricidal doses with small PVDRs where the arrays meet and tolerable radiation doses to normal tissues between the microbeams proximal and distal to the tumour in the paths of the arrays.
Bräuer-Krisch
E
E
European Synchrotron Radiation Facility, BP 220, 6, rue Horowitz, 38043 Grenoble Cedex, France. brauer@esrf.fr
Requardt
H
H
Régnard
P
P
Corde
S
S
Siegbahn
E
E
LeDuc
G
G
Brochard
T
T
Blattmann
H
H
Laissue
J
J
Bravin
A
A
D000818:Animals; D001921:Brain / Q000473:pathology* / Q000528:radiation effects*; D001932:Brain Neoplasms / Q000473:pathology* / Q000532:radiotherapy*; D005240:Feasibility Studies; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000517:prevention & control; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods*; D051381:Rats; D016896:Treatment Outcome