Forced exercise-induced flushing of tail skin in ovariectomized mice, as a new experimental model of menopausal hot flushes.
Hot flushes are the most common complaint of menopausal women. In the present study, a new animal model of hot flushes was established. Tail skin temperature was measured with a thermo tracer after mice were subjected to a forced exercise task using a motor driven treadmill. In ovariectomized mice, forced exercise for 10 min was most effective in increasing tail skin temperature over that of sham-operated mice. This elevation was blocked by estradiol replacement (1 mg/kg per week for 3 weeks), suggesting that our model simulates menopausal hot flushes.
Shuto
Hideki
H
Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.
Yamauchi
Atsushi
A
Ikeda
Munehiko
M
Sohda
Yoshio
Y
Koga
Ayako
A
Tominaga
Kohji
K
Egawa
Takashi
T
Kataoka
Yasufumi
Y
D000818:Animals; D004967:Estrogens / Q000172:deficiency*; D005260:Female; D019584:Hot Flashes / Q000209:etiology*; D051379:Mice; D008813:Mice, Inbred ICR; D023421:Models, Animal; D009569:Nitric Oxide / Q000096:biosynthesis; D010052:Ovariectomy; D010805:Physical Conditioning, Animal; D012867:Skin / Q000098:blood supply*; D012881:Skin Temperature
D004967:Estrogens; D009569:Nitric Oxide