A new FronTIR in targeted protein degradation and plant development.
Three papers, two in a recent issue of Nature and one in the July issue of Developmental Cell, identify a family of F box proteins as the long-sought receptors for the plant growth hormone auxin. The new studies reveal that auxin, a small molecule, regulates F box proteins, which are involved in ubiquitin-mediated protein degradation. This finding has profound implications for understanding plant physiology and development and for defining new modes of regulation of SCF ubiquitin ligase complexes.
Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.
Jennifer L
JL
Nemhauser
Joanne
J
Chory
D029681:Arabidopsis Proteins; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D044783:F-Box Proteins / Q000378:metabolism*; D018506:Gene Expression Regulation, Plant / Q000502:physiology; D007210:Indoleacetic Acids / Q000378:metabolism*; D010940:Plant Proteins; D010944:Plants / Q000196:embryology* / Q000235:genetics / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D044843:SKP Cullin F-Box Protein Ligases / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D015533:Transcriptional Activation / Q000502:physiology; D025801:Ubiquitin / Q000378:metabolism
C503841:ARF1 protein, Arabidopsis; D029681:Arabidopsis Proteins; D004268:DNA-Binding Proteins; D044783:F-Box Proteins; D007210:Indoleacetic Acids; D010940:Plant Proteins; D011956:Receptors, Cell Surface; D012097:Repressor Proteins; C501405:TIR1 protein, Arabidopsis; D014157:Transcription Factors; D025801:Ubiquitin; D044843:SKP Cullin F-Box Protein Ligases