New linear polyamine derivatives in spider venoms.
Linear free polyamines were characterized in the venom of the spiders Agelenopsis aperta, Hololena curta, and Paracoelotes birulai by RP-HPLC coupled to mass spectrometry. The several linear polyamines found were tetramine, pentamine, and hexamine derivatives. Some of these natural products were identified as N-hydroxylated, guanidylated, or acetylated compounds. In addition, the biosynthetical pathway leading to the formation of acylpolyamines in spider venoms is discussed.
Institute of Organic Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Manuel
M
Tzouros
Sergiy
S
Chesnov
Stefan
S
Bienz
Manfred
M
Hesse
Laurent
L
Bigler
D000818:Animals; D001952:Bridged-Ring Compounds / Q000032:analysis / Q000633:toxicity; D008401:Gas Chromatography-Mass Spectrometry; D008709:Methenamine / Q000032:analysis / Q000633:toxicity; D011073:Polyamines / Q000032:analysis* / Q000633:toxicity; D000644:Quaternary Ammonium Compounds / Q000032:analysis / Q000633:toxicity; D013111:Spider Venoms / Q000737:chemistry*
D001952:Bridged-Ring Compounds; D011073:Polyamines; D000644:Quaternary Ammonium Compounds; D013111:Spider Venoms; C040648:pentamine; C010349:tetramethylenedisulfotetramine; D008709:Methenamine