No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples.
BACKGROUND
It has been recently reported that a functional variant in the ZDHHC8 gene encoding a putative palmitoyltransferase directly confers susceptibility to schizophrenia in females ().


METHODS
We investigated the putative risk allele (rs175174) in four schizophrenia association samples including a Bulgarian proband and parent sample (474 trios) and three case-control panels of European origin (1028 patients/1253 control subjects) in an attempt to replicate these findings.


RESULTS
Our results do not support the hypothesis that genetic variation at rs175174 is associated with increased risk for schizophrenia nor do they suggest the presence of gender-specific differences.


CONCLUSIONS
Our data suggest that the reported genetic association by either represents type I error resulting from sampling variance or that rs175174 is in linkage disequilibrium (LD) with the functional variant for schizophrenia and different LD patterns obscure the detection of association.
Glaser
Beate
B
Department of Psychological Medicine, Cardiff University, Cardiff, United Kingdom.
Schumacher
Johannes
J
Williams
Hywel J
HJ
Jamra
Rami Abou
RA
Ianakiev
Nikolai
N
Milev
Radoi
R
Ohlraun
Stephanie
S
Schulze
Thomas G
TG
Czerski
Piotr M
PM
Hauser
Joanna
J
Jönsson
Erick G
EG
Sedvall
Göran C
GC
Klopp
Norman
N
Illig
Thomas
T
Becker
Tim
T
Propping
Peter
P
Williams
Nigel M
NM
Cichon
Sven
S
Kirov
George
G
Rietschel
Marcella
M
Murphy
Kieran C
KC
O'Donovan
Michael C
MC
Nöthen
Markus M
MM
Owen
Michael J
MJ
D000217:Acyltransferases / Q000235:genetics*; D000483:Alleles; D002031:Bulgaria / Q000208:ethnology; D002648:Child; D002892:Chromosomes, Human, Pair 22; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D014644:Genetic Variation; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012307:Risk Factors; D012559:Schizophrenia / Q000201:enzymology / Q000235:genetics*; D012737:Sex Factors; D044465:White People / Q000235:genetics*; D016335:Zinc Fingers / Q000235:genetics
D008565:Membrane Proteins; D000217:Acyltransferases; C488097:ZDHHC8 protein, human