Incidental stromal-predominant mixed epithelial-stromal tumors of the kidney: a mimic of intraparenchymal renal leiomyoma.
BACKGROUND
Mixed epithelial-stromal tumor of the kidney is a recently recognized benign renal tumor that usually occurs in adult women and typically forms a sizable lesion with solid and cystic areas. The recognized morphologic spectrum of this recently described entity is evolving.


OBJECTIVE
To review the clinicopathologic features of 3 small mixed epithelial-stromal tumors of the kidney that were incidental findings in kidneys removed for other reasons.


METHODS
The clinical presentation and morphologic findings of the 3 cases were reviewed. A panel of immunohistochemical stains was performed.


METHODS
Academic medical center.


RESULTS
All 3 lesions contained predominantly fascicles of smooth muscle mimicking leiomyoma, but they also had cellular subpopulations of smaller, müllerian-appearing stromal cells. Tubules present within the lesion were most abundant at the periphery, suggesting that they might be entrapped. Although only the spindled smooth muscle cells were immunoreactive for muscle markers desmin and actin, both the spindled smooth muscle cells and the cellular müllerian-appearing stromal cells demonstrated diffuse nuclear labeling for estrogen and progesterone receptors.


CONCLUSIONS
Mixed epithelial-stromal tumor of the kidney may present as an incidental stromal-predominant lesion within the kidney. Such lesions are easily confused with leiomyomas or stromal-predominant angiomyolipomas.
Division of Surgical Pathology, Johns Hopkins University, Baltimore, Md, USA.
Parin
P
Parikh
Theresa Y
TY
Chan
Jonathan I
JI
Epstein
Pedram
P
Argani
D000328:Adult; D000368:Aged; D018207:Angiomyolipoma / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis*; D007889:Leiomyoma / Q000175:diagnosis*; D008875:Middle Aged; D018193:Neoplasms, Complex and Mixed / Q000175:diagnosis*; D009375:Neoplasms, Glandular and Epithelial / Q000175:diagnosis*; D018235:Smooth Muscle Tumor / Q000175:diagnosis*; D017154:Stromal Cells / Q000473:pathology*