In vitro interactions of micafungin with other antifungal drugs against clinical isolates of four species of Cryptococcus.
The combination of micafungin (MFG) with amphotericin B (AMB), fluconazole, itraconazole, voriconazole, or ravuconazole was evaluated against 37 strains of four species of Cryptococcus by the checkerboard method. Antagonism was never seen. Synergy was observed for some isolates for each combination and was most frequent with MFG-AMB.
Serena
Carolina
C
Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain.
Fernández-Torres
Belkys
B
Pastor
F Javier
FJ
Trilles
Luciana
L
Lazéra
Márcia Dos Santos
Mdos S
Nolard
Nicole
N
Guarro
Josep
J
D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D003454:Cryptococcus / Q000145:classification / Q000187:drug effects*; D004347:Drug Interactions; D054714:Echinocandins; D006801:Humans; D055666:Lipopeptides; D008074:Lipoproteins / Q000494:pharmacology*; D000077551:Micafungin; D008826:Microbial Sensitivity Tests / Q000379:methods; D010456:Peptides, Cyclic / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D008074:Lipoproteins; D010456:Peptides, Cyclic; D014230:Triazoles; D000666:Amphotericin B; D000077551:Micafungin