Genome of the host-cell transforming parasite Theileria annulata compared with T. parva.
Theileria annulata and T. parva are closely related protozoan parasites that cause lymphoproliferative diseases of cattle. We sequenced the genome of T. annulata and compared it with that of T. parva to understand the mechanisms underlying transformation and tropism. Despite high conservation of gene sequences and synteny, the analysis reveals unequally expanded gene families and species-specific genes. We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host-cell transformation, and a Theileria-specific protein domain [frequently associated in Theileria (FAINT)] present in a large number of secreted proteins.
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. ap2@sanger.ac.uk
Arnab
A
Pain
Hubert
H
Renauld
Matthew
M
Berriman
Lee
L
Murphy
Corin A
CA
Yeats
William
W
Weir
Arnaud
A
Kerhornou
Martin
M
Aslett
Richard
R
Bishop
Christiane
C
Bouchier
Madeleine
M
Cochet
Richard M R
RM
Coulson
Ann
A
Cronin
Etienne P
EP
de Villiers
Audrey
A
Fraser
Nigel
N
Fosker
Malcolm
M
Gardner
Arlette
A
Goble
Sam
S
Griffiths-Jones
David E
DE
Harris
Frank
F
Katzer
Natasha
N
Larke
Angela
A
Lord
Pascal
P
Maser
Sue
S
McKellar
Paul
P
Mooney
Fraser
F
Morton
Vishvanath
V
Nene
Susan
S
O'Neil
Claire
C
Price
Michael A
MA
Quail
Ester
E
Rabbinowitsch
Neil D
ND
Rawlings
Simon
S
Rutter
David
D
Saunders
Kathy
K
Seeger
Trushar
T
Shah
Robert
R
Squares
Steven
S
Squares
Adrian
A
Tivey
Alan R
AR
Walker
John
J
Woodward
Dirk A E
DA
Dobbelaere
Gordon
G
Langsley
Marie-Adele
MA
Rajandream
Declan
D
McKeever
Brian
B
Shiels
Andrew
A
Tait
Bart
B
Barrell
Neil
N
Hall
D020816:Amino Acid Motifs; D000818:Animals; D002417:Cattle; D049109:Cell Proliferation; D002874:Chromosome Mapping; D002875:Chromosomes / Q000235:genetics; D017124:Conserved Sequence; D017125:Genes, Protozoan; D018503:Genome, Protozoan; D008018:Life Cycle Stages; D050356:Lipid Metabolism; D008214:Lymphocytes / Q000166:cytology / Q000469:parasitology; D008969:Molecular Sequence Data; D005810:Multigene Family; D010802:Phylogeny; D021382:Protein Sorting Signals / Q000235:genetics; D017434:Protein Structure, Tertiary; D020543:Proteome; D015800:Protozoan Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D017422:Sequence Analysis, DNA; D013045:Species Specificity; D026801:Synteny; D016615:Telomere / Q000235:genetics; D016796:Theileria annulata / Q000235:genetics* / Q000254:growth & development / Q000276:immunology / Q000472:pathogenicity; D016797:Theileria parva / Q000235:genetics* / Q000254:growth & development / Q000276:immunology / Q000472:pathogenicity
D021382:Protein Sorting Signals; D020543:Proteome; D015800:Protozoan Proteins