Application of functional MRI in epilepsy.
OBJECTIVE
To review the recent development of functional MRI application in epilepsy.


METHODS
Both Chinese and English language literatures were researched using MEDLINE/CD ROM (1996 - 2005) and the Chinese Biomedical Literature Disk (1996 - 2005).


METHODS
Published articles about functional MRI application and epilepsy were selected.


METHODS
Data were mainly extracted from 38 articles which are listed in the reference section of this review.


RESULTS
fMRI can be used to localize seizure foci through detecting these cerebral hemodynamic changes produced by epileptiform discharges. EEG-triggered fMRI, which has higher spatial and temporal resolution, helps to detect the spatiotemporal pattern of spike origin and propagation, and define localization of the epileptogenic focus. fMRI is also useful in language and memory cognitive function assessment and presurgical assessment of refractory epilepsy. Atypically distributed cognitive function areas can be detected by fMRI, because of cortical language and memory areas reorganization during long-term epileptic activity in patients with epilepsy.


CONCLUSIONS
fMRI technique plays a very important role in cognitive function and presurgical assessment of patients with epilepsy. It is meaningful for understanding pathogenesis of epilepsy.
Department of Radiology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, China.
Ai-hong
AH
Yu
Kun-cheng
KC
Li
Chang-fu
CF
Piao
Hong-li
HL
Li
D003071:Cognition; D004827:Epilepsy / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*