[NP-detecting DNA technologies: solving problems of applied biochemistry].
Heterozygosity of CANP3, ACTN3, and GHR genes in specialized collections was studied using state-of-the-art DNA technologies for DNA analysis. A new dinucleotide deletion (AC) at the beginning of exon 21 was identified in five individuals with heterozygous CANP3 gene. Analysis of polymorphism (SNP1747 C-->T) of ACTN3 gene demonstrated a positive association of allele C with a high muscular performance. Real-time PCR assay of SNP1630 (A-->C) in GHR gene suggested a putative negative association of allele C of this SNP with a high muscular performance.
Krakhmaleva
I N
IN
Shishkin
S S
SS
Shakhovskaia
N I
NI
Stoliarova
E B
EB
Plugov
A G
AG
Kniazev
A I
AI
Khomenkov
V G
VG
Shevelev
A B
AB
Chernov
N N
NN
D000185:Actinin / Q000235:genetics*; D000483:Alleles; D001483:Base Sequence; D002154:Calpain / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D005787:Gene Frequency; D006579:Heterozygote; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D008969:Molecular Sequence Data; D009124:Muscle Proteins / Q000235:genetics*; D018482:Muscle, Skeletal / Q000502:physiology*; D020641:Polymorphism, Single Nucleotide; D017384:Sequence Deletion
C118456:ACTN3 protein, human; D002352:Carrier Proteins; D007527:Isoenzymes; D009124:Muscle Proteins; D000185:Actinin; C105884:CAPN3 protein, human; D002154:Calpain; C051815:somatotropin-binding protein