No association of FOXP2 and PTPRZ1 on 7q31 with autism from the Japanese population.
Autism is a child-onset pervasive developmental disorder, with a significant role of genetic factors in its development. Genome-wide linkage studies have suggested a 7q region as a susceptibility locus for autism. We investigated several single nucleotide polymorphisms (SNPs) of Forkhead Box P2 (FOXP2) and Protein-Tyrosine Phosphatase, Receptor-type, Zeta-1 (PTPRZ1) at the 7q region in Japanese patients with autism and healthy controls. No significant difference was observed, after correction for the multiple testing, in allele, genotype or haplotype frequencies of the SNPs of FOXP2 or PTPRZ1 between patients and controls. No evidence was thus obtained for a major role of FOXP2 or PTPRZ1 in the development of autism.
Marui
Tetsuya
T
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Koishi
Shinko
S
Funatogawa
Ikuko
I
Yamamoto
Kenji
K
Matsumoto
Hideo
H
Hashimoto
Ohiko
O
Nanba
Eiji
E
Kato
Chieko
C
Ishijima
Michiko
M
Watanabe
Keiichiro
K
Kasai
Kiyoto
K
Kato
Nobumasa
N
Sasaki
Tsukasa
T
D000293:Adolescent; D000328:Adult; D001321:Autistic Disorder / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002897:Chromosomes, Human, Pair 7; D016001:Confidence Intervals; D005260:Female; D051858:Forkhead Transcription Factors; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology / Q000208:ethnology; D015810:Linkage Disequilibrium; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*
C465448:FOXP2 protein, human; D051858:Forkhead Transcription Factors; D014157:Transcription Factors; D017027:Protein Tyrosine Phosphatases