Synthesis of nitric oxide-releasing gold nanoparticles.
We report the synthesis of nitric oxide-releasing gold nanoparticles formed by place-exchange reaction of hexanethiol monolayer-protected clusters with diamine nitric oxide donor precursor molecules, which are subsequently converted to N-diazeniumdiolate NO donors. The nitric oxide release from the N-diazeniumdiolate-modified gold nanoparticles is tunable by varying the number and/or the chemical structure of the exchanged amine ligands. The size and stability of NO-releasing nanoparticles may prove useful for a range of biomedical and pharmaceutical applications.
Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Aaron R
AR
Rothrock
Robert L
RL
Donkers
Mark H
MH
Schoenfisch
D000588:Amines / Q000737:chemistry; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D006046:Gold / Q000737:chemistry*; D008956:Models, Chemical; D049329:Nanostructures; D036103:Nanotechnology / Q000379:methods*; D009569:Nitric Oxide / Q000737:chemistry*; D010316:Particle Size; D013997:Time Factors
D000588:Amines; D001672:Biocompatible Materials; D009569:Nitric Oxide; D006046:Gold