[Clinicopathological study of 4 renal juxtaglomerular cell tumors].
OBJECTIVE
To investigate the clinical characteristics, morphologic and immunohistochemical features, diagnosis, differential diagnosis, histogenesis and prognosis of renal juxtaglomerular cell tumor (JGCT).


METHODS
Light microscopic observation; immunohistochemical assay of CK8, E-cadherin/CK7, CD10, Vim, Actin, CD34, S100, HMB45, CD31, Chr, Syn and CD117, EM; and follow-up were done on all 4 surgically treated JGCT patients.


RESULTS
All 4 JGCT were observed in young adult with clinically uncontrolled severe hypertension. Grossly, the tumor was encapsulated and small in size. Microscopically, the tumor cells grew in sheets predominantly, but papillary and onion-like pattern could also be seen. The stroma contained prominent vasculature that consisted of numerous thin-wall vessels clustering around thick-walled vessels. Tumor cells were rather small, polygonal, with slightly eosinophilic cytoplasm and ill-defined cell border. Nuclei were uniform in size but nuclear atypia and mitosis could be seen. Numerous mast cells were scattered among the tumor cells, and tubules were identified in 3 of 4 cases with positive expression of distal tubule marker of E-cadherin/CK7. Tumor cells positively expressed Vim, Actin, calponin, and CD34. All cases presented ultrastructural features of distinct rhomboid-shaped crystal. There was no recurrence or metastasis but hypertension persisted in three during follow-up (mean 37 months) for all 4 JGCT patients.


CONCLUSIONS
JGCT, originating from the juxtaglomerular cell, has a distinct benign entity, and it is typically found in young adults with severe hypertension. It has a unique morphology and ultrastructure features and positive immunoreactivity to Vim, Actin, calponin and CD34.
Department of Pathology, Beijing Friendship Hospital, Capital University of Medical Sciences, Beijing 100050, China.
Li-na
LN
Liu
Guang-yong
GY
Chen
Peng
P
Wang
Yan-ning
YN
Zhang
Shu-hong
SH
Zhang
Chang-huai
CH
Zhang
Shou-famg
SF
Huang
D000199:Actins / Q000032:analysis; D000293:Adolescent; D000328:Adult; D018952:Antigens, CD34 / Q000032:analysis*; D002135:Calcium-Binding Proteins / Q000032:analysis*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007150:Immunohistochemistry; D007606:Juxtaglomerular Apparatus / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D007680:Kidney Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008840:Microfilament Proteins / Q000032:analysis*; D000096985:Calponins
D000199:Actins; D018952:Antigens, CD34; D002135:Calcium-Binding Proteins; D008840:Microfilament Proteins; D000096985:Calponins