Granulysin: a novel host defense molecule.
Granulysin is a novel cationic molecule present in the granules of cytotoxic T lymphocytes and natural killer cells. Cytotoxic T lymphocytes have long been associated with graft destruction in transplant rejection. Recent studies implicate granulysin in cell-mediated cytotoxicity, chemoattraction, immune activation and as a potential diagnostic biomarker for transplant rejection.
Krensky
Alan M
AM
Department of Pediatrics, Stanford University, Stanford, CA, USA. Krensky@stanford.edu
Clayberger
Carol
C
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000502:physiology*; D015415:Biomarkers; D003602:Cytotoxicity, Immunologic; D006084:Graft Rejection / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D000945:Antigens, Differentiation, T-Lymphocyte; D015415:Biomarkers; C075005:GNLY protein, human