Pyoderma gangraenosum associated with autoimmune thyreopathy and hyperandrogenic syndrome.
An unusual clinical appearance and course of pyoderma gangraenosum (PG) in a 35-year-old woman is presented. Signs of both the ulcerative and vegetative forms of PG were expressed. The association of two systemic diseases, the autoimmune thyreopathy and the hyperandrogenic syndrome were observed in a female. The recommended conventional therapy for PG: corticosteroids, antibiotics, cyclosporine and cyclophosphamide yielded a poor response, whereas after thyroidectomy and reaching an euthyroid state the symptoms receded. This close association of PG and autoimmune thyreopathy supports the autoimmune concept of PG.
Dept. of Dermatovenereology, St. Ann's Faculty Hospital, Pekarská 53, 656 91 Brno,Czech Republic.
Miroslav
M
Necas
Vera
V
Semrádova
Vladimír
V
Vaskù
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D013956:Antithyroid Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000150:complications / Q000188:drug therapy; D002231:Carbimazole / Q000627:therapeutic use; D005260:Female; D006111:Graves Disease / Q000150:complications*; D006801:Humans; D017588:Hyperandrogenism / Q000150:complications; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D017511:Pyoderma Gangrenosum / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D013965:Thyroidectomy; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D013956:Antithyroid Agents; D007166:Immunosuppressive Agents; D002231:Carbimazole