Written parental consent in school-based HIV/AIDS prevention research.
OBJECTIVE
We examined the process of obtaining "active," written parental consent for a school-based HIV/AIDS prevention project in a South African high school by investigating (1) parental consent form return rates, (2) parents' recall and knowledge of the research, and (3) the extent to which this consent procedure represented parents' wishes about their child's involvement in the research.


METHODS
This cross-sectional descriptive study comprised interviews with parents of children in grades eight and nine in a poor, periurban settlement in Cape Town.


RESULTS
Within 2 weeks, 94% of 258 parents responded to a letter requesting written consent and of those, 93% consented, but subsequent interviews showed that 65% remembered seeing the consent form. At the end of the interview, 99% consented to their child's participation.


CONCLUSIONS
These findings challenge many of the assumptions underlying active written parental consent. However, they should not be used to deny adolescents at high risk of HIV infection the opportunity to participate in prevention trials. Rather, researchers together with the communities in which the research is undertaken need to decide on appropriate informed consent strategies.
Mathews
Catherine
C
Health Systems Research Unit, Medical Research Council, PO Box 19070, Tygerberg 7505, South Africa. cm@cormack.uct.ac.za
Guttmacher
Sally J
SJ
Flisher
Alan J
AJ
Mtshizana
Yolisa
Y
Hani
Andiswa
A
Zwarenstein
Merrick
M
D000293:Adolescent; D003430:Cross-Sectional Studies; D015658:HIV Infections / Q000517:prevention & control*; D006801:Humans; D033282:Parental Consent / Q000523:psychology / Q000706:statistics & numerical data*; D012106:Research; D012572:School Health Services / Q000458:organization & administration*; D013019:South Africa