Correlation between reduction potentials and inhibitory effects on Epstein-Barr virus activation of poly-substituted anthraquinones.
As a continuation of our studies using natural and synthetic products as cancer chemopreventive agents, we examined the reduction potentials of some poly-substituted anthraquinones in phosphate buffer at pH 7.2 by means of cyclic voltammetry. A definite correlation has been found between the reduction potentials and the inhibitory effects of the poly-substituted anthraquinones on Epstein-Barr virus early antigen activation. It has been further shown that the correlation can be enhanced by introducing log P as an additional parameter.
Faculty of Pharmaceutical Sciences, Kobe Pharmaceutical University, Higashinada, Kobe 658-8558, Japan. j-koyama@kobepharma-u.ac.jp
Junko
J
Koyama
Izumi
I
Morita
Norihiro
N
Kobayashi
Toshiyuki
T
Osakai
Hoyoku
H
Nishino
Harukuni
H
Tokuda
D000880:Anthraquinones / Q000737:chemistry* / Q000494:pharmacology*; D002021:Buffers; D002460:Cell Line; D004854:Herpesvirus 4, Human / Q000187:drug effects* / Q000502:physiology*; D006801:Humans; D020128:Inhibitory Concentration 50; D010084:Oxidation-Reduction / Q000187:drug effects; D010710:Phosphates; D014775:Virus Activation / Q000187:drug effects*
D000880:Anthraquinones; D002021:Buffers; D010710:Phosphates