Genome of the host-cell transforming parasite Theileria annulata compared with T. parva.
Theileria annulata and T. parva are closely related protozoan parasites that cause lymphoproliferative diseases of cattle. We sequenced the genome of T. annulata and compared it with that of T. parva to understand the mechanisms underlying transformation and tropism. Despite high conservation of gene sequences and synteny, the analysis reveals unequally expanded gene families and species-specific genes. We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host-cell transformation, and a Theileria-specific protein domain [frequently associated in Theileria (FAINT)] present in a large number of secreted proteins.
Pain
Arnab
A
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. ap2@sanger.ac.uk
Renauld
Hubert
H
Berriman
Matthew
M
Murphy
Lee
L
Yeats
Corin A
CA
Weir
William
W
Kerhornou
Arnaud
A
Aslett
Martin
M
Bishop
Richard
R
Bouchier
Christiane
C
Cochet
Madeleine
M
Coulson
Richard M R
RM
Cronin
Ann
A
de Villiers
Etienne P
EP
Fraser
Audrey
A
Fosker
Nigel
N
Gardner
Malcolm
M
Goble
Arlette
A
Griffiths-Jones
Sam
S
Harris
David E
DE
Katzer
Frank
F
Larke
Natasha
N
Lord
Angela
A
Maser
Pascal
P
McKellar
Sue
S
Mooney
Paul
P
Morton
Fraser
F
Nene
Vishvanath
V
O'Neil
Susan
S
Price
Claire
C
Quail
Michael A
MA
Rabbinowitsch
Ester
E
Rawlings
Neil D
ND
Rutter
Simon
S
Saunders
David
D
Seeger
Kathy
K
Shah
Trushar
T
Squares
Robert
R
Squares
Steven
S
Tivey
Adrian
A
Walker
Alan R
AR
Woodward
John
J
Dobbelaere
Dirk A E
DA
Langsley
Gordon
G
Rajandream
Marie-Adele
MA
McKeever
Declan
D
Shiels
Brian
B
Tait
Andrew
A
Barrell
Bart
B
Hall
Neil
N
D020816:Amino Acid Motifs; D000818:Animals; D002417:Cattle; D049109:Cell Proliferation; D002874:Chromosome Mapping; D002875:Chromosomes / Q000235:genetics; D017124:Conserved Sequence; D017125:Genes, Protozoan; D018503:Genome, Protozoan; D008018:Life Cycle Stages; D050356:Lipid Metabolism; D008214:Lymphocytes / Q000166:cytology / Q000469:parasitology; D008969:Molecular Sequence Data; D005810:Multigene Family; D010802:Phylogeny; D021382:Protein Sorting Signals / Q000235:genetics; D017434:Protein Structure, Tertiary; D020543:Proteome; D015800:Protozoan Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D017422:Sequence Analysis, DNA; D013045:Species Specificity; D026801:Synteny; D016615:Telomere / Q000235:genetics; D016796:Theileria annulata / Q000235:genetics* / Q000254:growth & development / Q000276:immunology / Q000472:pathogenicity; D016797:Theileria parva / Q000235:genetics* / Q000254:growth & development / Q000276:immunology / Q000472:pathogenicity
D021382:Protein Sorting Signals; D020543:Proteome; D015800:Protozoan Proteins