A novel synthesis and molluscicidal activity of some functionally substituted pyridine, pyrido[3,2-c]pyridazine, and pyrido[3,2-c]pyridazino[2',3'-a]quinazoline derivatives.
Ethyl benzoylacetate reacts with the malononitrile dimer to afford 4-amino-5-benzoyl-2-dicyano methyl-6-hydroxypyridine, which undergoes the coupling reaction with aromatic diazonium salts to afford azo derivatives. These azo derivatives could be cyclized into pyrido[3,2-c]pyridazine and pyrido[3,2-c]pyridazino[2',3'-a]quinazoline derivatives upon reflux in ethanolic NaOH, presumably via their hydrazo tautomers. The molluscicidal activity of these compounds was evaluated.
Abdelrazek
Fathy M
FM
Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt. prof_fmrazek@yahoo.com
Fathy
Alaa El-Din M
Ael-D
D000818:Animals; D001700:Biomphalaria / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007536:Isomerism; D008975:Molluscacides / Q000138:chemical synthesis* / Q000633:toxicity; D011724:Pyridazines / Q000138:chemical synthesis* / Q000633:toxicity; D011725:Pyridines / Q000138:chemical synthesis* / Q000633:toxicity; D021281:Quantitative Structure-Activity Relationship; D011799:Quinazolines / Q000138:chemical synthesis* / Q000633:toxicity; D023382:Toxicity Tests, Acute / Q000379:methods
D008975:Molluscacides; D011724:Pyridazines; D011725:Pyridines; D011799:Quinazolines