Gold(I)-phosphine catalyst for the highly chemoselective dehydrogenative silylation of alcohols.
[reaction: see text] A gold(I) complex of Xantphos AuCl(xantphos) catalyzes the dehydrogenative silylation of alcohols with high chemoselectivity and solvent tolerance. It is selective for the silylation of hydroxyl groups in the presence of alkenes, alkynes, alkyl halides (RCl, RBr), ketones, aldehydes, conjugated enones, esters, and carbamates.
Division of Chemistry, Graduate School of Science, Hokkaido University, JST, Sapporo, Japan. hajito@sci.hokudai.ac.jp
Hajime
H
Ito
Katsuhiro
K
Takagi
Takahiro
T
Miyahara
Masaya
M
Sawamura