Harmful and protective roles of neutrophils in sepsis.
The current studies demonstrate protective and harmful effects of neutrophils (PMN) during experimental sepsis after cecal ligation and puncture (CLP). It is known that CLP induces signaling defects in blood PMN. When PMN were depleted 12 h after CLP, there were dramatic reductions in levels of bacteremia, evidence for reduced liver and renal dysfunction, sharp reductions in serum levels of cytokines (IL-1beta, IL-6, IL-10, TNF-alpha, and IL-2), and improved survival. In contrast, PMN depletion before CLP resulted in substantial increases in bacteremia and no evidence for attenuation of liver and renal failure dysfunction. These data suggest that at the onset of sepsis, PMN are important in regulating the levels of bacteremia, whereas after the onset of sepsis, as they lose innate immune functions, their presence is associated with higher levels of bacteremia and intensified organ dysfunction.
Department of Pathologycine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Laszlo M
LM
Hoesel
Thomas A
TA
Neff
Simona B
SB
Neff
John G
JG
Younger
Eric W
EW
Olle
Hongwei
H
Gao
Matthew J
MJ
Pianko
Kurt D
KD
Bernacki
J Vidya
JV
Sarma
Peter A
PA
Ward
D000818:Animals; D007074:Immunoglobulin G / Q000494:pharmacology; D007668:Kidney / Q000276:immunology; D008099:Liver / Q000276:immunology; D051379:Mice; D009102:Multiple Organ Failure / Q000097:blood; D009503:Neutropenia; D009504:Neutrophils / Q000276:immunology* / Q000502:physiology*; D009928:Organ Specificity; D009195:Peroxidase / Q000032:analysis; D051381:Rats; D018805:Sepsis / Q000097:blood / Q000276:immunology* / Q000503:physiopathology*; D013997:Time Factors
D007074:Immunoglobulin G; D009195:Peroxidase