Reduced glucose metabolism in temporo-parietal cortices of women with borderline personality disorder.
Individuals with borderline personality disorder (BPD) and posttraumatic stress disorder (PTSD) often experience dissociative symptoms. Evidence is increasing that stress-related hyperglutamatergic states may contribute to dissociative symptoms and neurodegeneration in temporo-parietal cortical areas. Seventeen young women with BPD who had been exposed to severe childhood physical/sexual abuse and presented with pronounced dissociative symptoms underwent (18)fluoro-2-deoxyglucose positron emission tomography (FDG-PET). Nine healthy, matched volunteers served as comparison subjects. Borderline subjects displayed reduced FDG uptake (as analyzed by SPM) in the right temporal pole/anterior fusiform gyrus and in the left precuneus and posterior cingulate cortex. Impaired memory performance among borderline subjects was significantly correlated with metabolic activity in ventromedial and lateral temporal cortices. Our results demonstrate regional hypometabolism in temporal and medial parietal cortical regions known to be involved in episodic memory consolidation and retrieval. Currently, the precuneus/posterior cingulate cortex is modeled as part of a network of tonically active brain regions that continuously gather information about the world around and within us. Decreased resting metabolic rate of these regions may reflect dissociative symptoms and possibly also identity disturbances and interpersonal difficulties of individuals with BPD.
Lange
Claudia
C
Department of Psychiatry and Psychotherapy, University of Göttingen, Von-Siebold-Str. 5, 37075 Göttingen, Germany.
Kracht
Lutz
L
Herholz
Karl
K
Sachsse
Ulrich
U
Irle
Eva
E
D000328:Adult; D001883:Borderline Personality Disorder / Q000453:epidemiology / Q000378:metabolism* / Q000503:physiopathology*; D002648:Child; D002649:Child Abuse / Q000706:statistics & numerical data; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology; D004213:Dissociative Disorders / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D010296:Parietal Lobe / Q000378:metabolism* / Q000503:physiopathology*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D013313:Stress Disorders, Post-Traumatic / Q000378:metabolism / Q000503:physiopathology; D011795:Surveys and Questionnaires; D013702:Temporal Lobe / Q000378:metabolism* / Q000503:physiopathology*; D014888:Wechsler Scales
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose