[Structural and metabolic characteristics of erythrocytes in patients with systemic vasculitis].
We studied the functional and metabolic changes of erythrocytes in systemic vasculitis (SV). The below was detected: an increasing intensity of blood chemiluminescence, a higher concentration of TBA-positive substances in erythrocyte membranes, inhibited Na+, K+ - and Ca2+ -activated and Mg2+ -related ATPases in erythrocytes and a reduced osmotic and acidic resistance of erythrocytes. An enhanced aggregation ability of erythrocytes and their inhibited desagregation were observed in hemorrhagic vasculitis an especially in microscopic polyangiitis. The revealed changes characterize the significance of the erythrocyte pathology in thrombosis and development of hemorrhagic disorders in SV patients.
M M
MM
Fazlyev
A Zh
AZh
Gil'manov
D000293:Adolescent; D000328:Adult; D000368:Aged; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism; D004903:Erythrocyte Aggregation; D004910:Erythrocyte Membrane / Q000201:enzymology / Q000378:metabolism; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009996:Osmotic Fragility; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014657:Vasculitis / Q000097:blood* / Q000201:enzymology / Q000378:metabolism
D005609:Free Radicals; D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase