Involvement of streptococcal mitogenic exotoxin Z in streptococcal toxic shock syndrome.
We report a nonfatal case of streptococcal toxic shock syndrome (STSS) caused by a Streptococcus pyogenes emm118 strain encoding a novel variant of streptococcal mitogenic exotoxin Z (SMEZ-34). This variant was responsible for the major mitogenic activity in the cell culture supernatant. Patient sera showed seroconversion toward SMEZ, implying a role for this toxin in STSS.
Yang
Lily
L
Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand.
Thomas
Mark
M
Woodhouse
Andrew
A
Martin
Diana
D
Fraser
John D
JD
Proft
Thomas
T
D000328:Adult; D000942:Antigens, Bacterial / Q000235:genetics / Q000378:metabolism; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000378:metabolism; D001427:Bacterial Toxins / Q000235:genetics / Q000378:metabolism*; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D005098:Exotoxins / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D012772:Shock, Septic / Q000382:microbiology* / Q000503:physiopathology; D013297:Streptococcus pyogenes / Q000145:classification* / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*
D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001427:Bacterial Toxins; D002352:Carrier Proteins; D005098:Exotoxins; C107894:mitogenic exotoxin Z protein, Streptococcus; C014689:streptococcal M protein