Comparison of two tricarbocyanine-based dyes for fluorescence optical imaging.
Optical technologies are evolving in many biomedical areas including the biomedical imaging disciplines. Regarding the absorption properties of physiological molecules in living tissue, the optical window ranging from 700 to 900 nm allows to use fluorescent dyes for novel diagnostic solutions. Here we investigate the potential of two different carbocyanine-based dyes fluorescent in the near infrared as contrast agents for in vivo imaging of subcutaneously grown tumours in laboratory animals. The primary aim was to modify the physicochemical properties of the previously synthesized dye SIDAG to investigate the effect on the in vivo imaging properties.
Optical Imaging and New Modalities Research, Research Laboratories, Schering AG, Müllerstrasse, 13342 Berlin, Germany. christin.perlitz@schering.de
Christin
C
Perlitz
Kai
K
Licha
Frank-Detlef
FD
Scholle
Bernd
B
Ebert
Malte
M
Bahner
Peter
P
Hauff
Kurt Thomas
KT
Moesta
Michael
M
Schirner
D000818:Animals; D002232:Carbocyanines / Q000737:chemistry*; D005260:Female; D005456:Fluorescent Dyes / Q000737:chemistry*; D007259:Infrared Rays; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008856:Microscopy, Fluorescence / Q000295:instrumentation* / Q000379:methods; D015394:Molecular Structure; D009368:Neoplasm Transplantation; D055095:Optics and Photonics / Q000295:instrumentation*; D018243:Teratocarcinoma / Q000098:blood supply / Q000473:pathology
C430879:1,1'-bis-(4-sulfobutyl)indotricarbocyanine-5,5'-dicarboxylic acid diglucamide; D002232:Carbocyanines; D005456:Fluorescent Dyes