Standardisation of synovial tissue infiltrate analysis: how far have we come? How much further do we need to go?
Changes in cellular infiltrate and expression of cytokines, chemokines, and cell adhesion molecules as a result of therapeutic interventions in rheumatoid arthritis can be demonstrated in the synovial membrane. However, before synovial tissue analysis can be used as an outcome measure in such studies, standardisation of the site and method of synovial tissue acquisition, methods of tissue processing, and appropriate methods of detection and measurement of cell lineage specific markers and relevant biological proteins is needed.
Rheumatology Research Unit, Repatriation General Hospital, Adelaide, South Australia. malcolm.smith@rgh.sa.gov.au
M D
MD
Smith
D
D
Baeten
A-K
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Ulfgren
I B
IB
McInnes
O
O
Fitzgerald
B
B
Bresnihan
P P
PP
Tak
D
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Veale
D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000473:pathology*; D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy / Q000379:methods / Q000592:standards; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods / Q000592:standards; D007124:Immunoenzyme Techniques / Q000592:standards; D013583:Synovial Membrane / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*
D015415:Biomarkers