Cerebrospinal fluid S-100B concentrations in normal and diseased cattle.
We measured the concentrations of S-100B, a marker protein used in humans to detect brain damage, in the cerebrospinal fluid (CSF) of clinically normal cattle (n=15, mean age +/- SD: 31.8 +/- 37.5 months) and of cattle with various inflammatory disorders (n=43, 70.6 +/- 31.9 months). The mean +/- SD CSF S-100B level was 2.9 +/- 1.6 ng/ml in the normal group and 7.0 +/- 7.4 ng/ml in the diseased group. Thirteen diseased cattle that had developed no obvious neurological signs showed abnormally high S-100B concentrations (> 8.0 ng/ml), whereas the two cattle with neurological disorders did not. No particular disease could be related to the S-100B rise. Therefore, it remains inconclusive whether measurement of CSF S-100B concentration is useful in veterinary neurological diagnosis.
Department of Safety Research, National Institute of Animal Health, Tsukuba, Ibaraki, Japan.
Nobuaki
N
Shimada
Takamasa
T
Inoue
Hideo
H
Murata
D000367:Age Factors; D000818:Animals; D002417:Cattle / Q000134:cerebrospinal fluid*; D002418:Cattle Diseases / Q000134:cerebrospinal fluid*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D007249:Inflammation / Q000134:cerebrospinal fluid / Q000662:veterinary*; D009414:Nerve Growth Factors / Q000134:cerebrospinal fluid*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000134:cerebrospinal fluid*
D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins