Silent chemoattractant receptors: D6 as a decoy and scavenger receptor for inflammatory CC chemokines.
The chemokine system includes at least three "silent" receptors, DARC, D6 and CCX CKR, with distinct specificity and tissue distribution. D6 binds most inflammatory, but not homeostatic, CC chemokines and shuttles in a ligand-independent way from the plasma membrane to endocytic compartments where chemokines are targeted to degradation. In vitro and in vivo evidence, including results with gene-targeted mice, is consistent with the view that D6 acts as a decoy and scavenger for inflammatory CC chemokines. Thus, D6 has unique functional and structural features, which make it ideally adapted to act as a chemokine decoy and scavenger receptor, strategically located on lymphatic endothelium to dampen inflammation in tissues and draining lymph nodes.
Institute of General Pathology, Medical Faculty, University of Milan, I-20133 Milan, Italy.
Massimo
M
Locati
Yeny Martinez de la
YM
Torre
Emanuela
E
Galliera
Raffaella
R
Bonecchi
Haribabu
H
Bodduluri
Gianluca
G
Vago
Annunciata
A
Vecchi
Alberto
A
Mantovani
D000818:Animals; D019742:Chemokines, CC / Q000502:physiology*; D004375:Duffy Blood-Group System / Q000276:immunology; D006801:Humans; D007249:Inflammation; D007962:Leukocytes / Q000276:immunology / Q000378:metabolism; D054447:Receptors, CCR10; D011956:Receptors, Cell Surface / Q000276:immunology; D019707:Receptors, Chemokine / Q000502:physiology*; D051116:Receptors, Scavenger / Q000502:physiology*; D000097628:Chemokine Receptor D6
D019742:Chemokines, CC; D004375:Duffy Blood-Group System; D054447:Receptors, CCR10; D011956:Receptors, Cell Surface; D019707:Receptors, Chemokine; D051116:Receptors, Scavenger; D000097628:Chemokine Receptor D6; C473745:ACKR1 protein, human