Association and linkage analyses of interleukin-6 gene 634C/G polymorphism and bone phenotypes in Chinese.
In this study, we tested the interleukin-6 (IL-6) gene as an important candidate gene for its linkage and association with the variation of bone phenotypes (bone mineral density [BMD] and bone size) in young Chinese female subjects. We genotyped the IL-6 gene at the -634C/G restriction fragment length polymorphism (RFLP) site (ID, RS1800796) in 1263 individuals from 402 Chinese nuclear families, composed of both parents and at least one healthy daughter (mean age +/- SD, 31.4 +/- 5.8 years). Using the daughters' bone phenotypes, we tested total-family association, within-family association (via transmission disequilibrium test, [TDT]), and linkage, between the -634C/G marker and bone phenotypes at the spine and the hip. No significant association or linkage was found for bone size and BMD, although a trend was observed for linkage between the IL-6 gene -634C/G marker and L1-4 spinal BMD (adjusted for age, weight, and height). Our results, together with the findings from other studies, indicate that the IL-6 gene, although important for postmenopausal bone loss, may have a limited impact on peak bone mass variation in a Chinese population.
Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081 P. R. China.
Shu-Feng
SF
Lei
Yao-Zhong
YZ
Liu
Fei-Yan
FY
Deng
Yu-Mei
YM
Li
Miao-Xin
MX
Li
Hong-Wen
HW
Deng
D000328:Adult; D000368:Aged; D015519:Bone Density / Q000235:genetics* / Q000276:immunology*; D001842:Bone and Bones / Q000033:anatomy & histology; D002681:China; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic
D015850:Interleukin-6