AIT-082 as a potential neuroprotective and regenerative agent in stroke and central nervous system injury.
The synthetic purine 4-[[3-(1,6 dihydro-6-oxo-9-purin-9-yl)-1-oxypropyl] amino] benzoic acid (AIT-082, Neotrofin, leteprinim potassium) possesses several biological properties of note: it stimulates outgrowth of neurites from PC12 cells and neurones, stimulates synthesis and/or release of neurotrophic factors from astrocytes, enhances nerve fibre regeneration in vivo and enhances of memory in animals and humans. AIT-082 also protects against glutamate neurotoxicity in vitro and in vivo, which has led to successful tests of AIT-082 in animal models of acute central nervous system injury. In such cases, AIT-082 probably functions by both acutely reducing glutamate excitotoxicity and, over a longer period, by enhancing neuronal sprouting and functional recovery.
Rathbone
M P
MP
Department of Medicine, McMaster University Health Sciences Center, Hamilton, ON L8N 2S1, Canada. mrathbon@fhs.csu.mcmaster
Middlemiss
P J
PJ
Crocker
C E
CE
Glasky
M S
MS
Juurlink
B H
BH
Ramirez
J J
JJ
Ciccarelli
R
R
Di Iorio
P
P
Caciagli
F
F