Biotransformation of ferulic acid into two new dihydrotrimers by Momordica charantia peroxidase.
As a result of a continuing investigation of the biotransformation of ferulic acid with H2O2/Momordica charantia peroxidase at pH 5.0 in the presence of acetone, triFA1 (1) and triFA2 (2), two new FA dehydrotrimers, have been isolated. The structures were elucidated from the spectroscopic data including 2D-NMR such as HSQC, HMBC and NOESY data. TriFA1 (1) is a unique FA dehydrotrimer possessing a 3a,9b-dihydro-1H-furo[3,4-c][1]benzopyran-3(4H)-one ring system. The possible mechanism for the formation of triFA1 was also discussed.
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, The People's Republic of China.
Hai-Li
HL
Liu
Ling-Yi
LY
Kong
Yoshiaki
Y
Takaya
Masatake
M
Niwa
D001711:Biotransformation; D003373:Coumaric Acids / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D029777:Momordica charantia / Q000201:enzymology*; D010544:Peroxidases / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
D003373:Coumaric Acids; D011108:Polymers; C004999:ferulic acid; D010544:Peroxidases