Microwave drying of granules containing a moisture-sensitive drug: a promising alternative to fluid bed and hot air oven drying.
The impact of microwave drying and binders (copolyvidone and povidone) on the degradation of acetylsalicylic acid (ASA) and physical properties of granules were compared with conventional drying methods. Moist granules containing ASA were prepared using a high shear granulator and dried with hot air oven, fluid bed or microwave (static or dynamic bed) dryers. Percent ASA degradation, size and size distribution, friability and flow properties of the granules were determined. Granules dried with the dynamic bed microwave dryer showed the least amount of ASA degradation, followed by fluid bed dryer, static bed microwave oven and hot air oven. The use of microwave drying with a static granular bed adversely affected ASA degradation and drying capability. Dynamic bed microwave dryer had the highest drying capability followed by fluid bed, static bed microwave dryer and conventional hot air oven. The intensity of microwave did not affect ASA degradation, size distribution, friability and flow properties of the granules. Mixing/agitating of granules during drying affected the granular physical properties studied. Copolyvidone resulted in lower amount of granular residual moisture content and ASA degradation on storage than povidone, especially for static bed microwave drying. In conclusion, microwave drying technology has been shown to be a promising alternative for drying granules containing a moisture-sensitive drug.
Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore.
Sze Nam
SN
Chee
Anne Lene
AL
Johansen
Li
L
Gu
Jan
J
Karlsen
Paul Wan Sia
PW
Heng
D000388:Air; D001241:Aspirin / Q000737:chemistry; D006358:Hot Temperature; D008872:Microwaves; D004364:Pharmaceutical Preparations; D014867:Water / Q000737:chemistry*
D004364:Pharmaceutical Preparations; D014867:Water; D001241:Aspirin