[Spontaneous resolution of vanishing bile duct syndrome in Hodgkin's lymphoma].
Cholestasis in a patient with Hodgkin's disease is uncommon, and the causes of cholestasis are mainly direct tumor involvement of the liver, hepatotoxic effects of drugs, viral hepatitis, sepsis and opportunistic infections. Vanishing bile duct syndrome (VBDS) represents a very rare cause for cholestasis in this disease. We report here on a case of a 45-year-old man who developed VBDS during the complete remission stage of Hodgkin's lymphoma. There was no history of hepatitis or intravenous drug abuse, and the patient had negative results for hepatitis A virus, hepatitis B virus, hepatitis C virus, cytomegalovirus, and human immunodeficiency virus. The serological studies for antinuclear antibodies, anti-mitochondrial antibodies and anti-smooth muscle antibodies were also negative. Liver biopsy disclosed the absence of interlobular bile ducts in 9 of 10 portal tracts without any active lymphocyte infiltration and there were no Reed-Sternberg cell in the liver. The patient's cholestasis was in remission and the serum bililrubin level was normalized after two months without treatment, but tumor recurrence was noted at multiple sites of the abdominal lymph nodes on follow-up abdomino-pelvic computed tomogram.
Department of Hepatology, Korea University College of Medicine, Seoul, Korea.
Woo Sik
WS
Han
Eun Suk
ES
Jung
Youn Ho
YH
Kim
Chung Ho
CH
Kim
Sung Chul
SC
Park
Ji Yeon
JY
Lee
Yun Jung
YJ
Chang
Jong Eun
JE
Yeon
Kwan Soo
KS
Byun
Chang Hong
CH
Lee
D000328:Adult; D001649:Bile Duct Diseases / Q000150:complications* / Q000175:diagnosis; D001653:Bile Ducts, Intrahepatic; D002779:Cholestasis / Q000150:complications*; D006689:Hodgkin Disease / Q000150:complications*; D006801:Humans; D008297:Male; D012075:Remission, Spontaneous