Desmodium gangeticum: a potent anti-ulcer agent.
The present study was designed to investigate anti-ulcerogenic property of ethanolic extract of Desmodium gangeticum (DG) against cold restraint (CRU, 2 hr cold restraint stress), aspirin (ASP, 150 mg/kg orally), alcohol (AL, absolute alcohol 1 ml/200gm) and pyloric ligation (PL, 4 hr pylorus ligation) induced gastric ulcer models in Sprague Dawley rats, and histamine (HST, 0.25 mg/kg) induced duodenal ulcer in guinea pigs. We found that DG at a dose of 200mg/kg, (orally), markedly decreased the incidence of ulcers in all the above models. DG showed significant protection against CRU (68.37%), AL (88.87%), ASP (38.2%), PL (40.63%) and HST (63.15%) induced ulcer models, whereas standard drug omeprazole (OMZ) showed protection index of 83.86, 56.35, 70.31 and 84.21%, respectively in CRU, ASP, PL and HST models. Sucralfate as standard drug showed 92.64% protection in AL model. DG significantly reduced acid secretion 41.61%, whereas OMZ produced 43.13% reduction. Treatment with DG showed increase in mucin secretion by 56.17%, whereas OMZ showed 12.45% increase. Anti-ulcer effect of DG may be due to its cytoprotective effect along with antisecretory activity and could act as a potent therapeutic agent against peptic ulcer disease.
Dharmani
Poonam
P
Division of Pharmacology, Central Drug Research Institute, Lucknow 226 001, India.
Mishra
Pushpesh Kumar
PK
Maurya
Rakesh
R
Chauhan
Vinay Singh
VS
Palit
Gautam
G
D000438:Alcohols / Q000494:pharmacology; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D003080:Cold Temperature; D004381:Duodenal Ulcer / Q000188:drug therapy*; D000431:Ethanol / Q000737:chemistry; D007887:Fabaceae / Q000378:metabolism; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000378:metabolism; D008297:Male; D009853:Omeprazole / Q000737:chemistry / Q000494:pharmacology; D010437:Peptic Ulcer / Q000378:metabolism; D010865:Pilot Projects; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000188:drug therapy*; D013392:Sucralfate / Q000737:chemistry / Q000494:pharmacology
D000438:Alcohols; D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D000431:Ethanol; D013392:Sucralfate; D006632:Histamine; D009853:Omeprazole; D001241:Aspirin