Solitary pancreas metastasis from AFP-producing gastric cancer: report of a case.
We herein present a case of resected pancreatic metachronous metastasis arising from alpha-fetoprotein-producing gastric cancer. A 75-year-old man underwent distal gastrectomy for alpha-fetoprotein-producing gastric cancer in November 1999. The staging group of TNM classification was Stage IIIA. The serum AFP level normalized after surgical resection. During the follow-up period, it increased to 42ng/mL in January 2002, and up to 550ng/mL in July 2002: Abdominal computed tomography disclosed a 4-cm mass in the tail of the pancreas and under the diagnosis of pancreas metastasis, distal pancreatectomy with splenectomy was performed. Following this, serum alpha-fetoprotein declined to 61ng/mL, and the postoperative course was uneventful. But it elevated again to 200ng/mL in August, and to 3500ng/mL in September 2002. Computed tomography revealed multiple liver metastases. He was treated with TS-1, but hepatic lesions continued to grow and he died in March 2003. To our knowledge, this case is the first report of resection of solitary pancreas metastasis of alpha-fetoprotein-producing gastric cancer.
Natsume
Toshiyuki
T
Department of Surgery, Funabashi Municipal Medical Center, Funabashi, Chiba, Japan. natsu-22@cameo.plala.or.jp
Watanabe
Yoshiji
Y
Maruyama
Takashi
T
Tanaka
Hajime
H
Shimizu
Takanori
T
Saito
Tsuyoshi
T
Kobayashi
Yutaka
Y
Tohnosu
Noriyuki
N
Uehara
Toshitaka
T
Shimizu
Shin-ichiro
S
Ochiai
Takenori
T
D000368:Aged; D017809:Fatal Outcome; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000556:secondary* / Q000601:surgery; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology*; D000509:alpha-Fetoproteins / Q000378:metabolism*
D000509:alpha-Fetoproteins