Golgi tethering factors.
Transport of cargo to, through and from the Golgi complex is mediated by vesicular carriers and transient tubular connections. In this review, we describe vesicle tethering events with the understanding that similar events occur during transport via larger structures. Tethering factors can be generally divided into a group of coiled-coil proteins and a group of multi-subunit complexes. Current evidence suggests that these factors function in a variety of membrane-membrane tethering events at the Golgi complex, interact with SNARE molecules, and are regulated by small GTPases of the Rab and Arl families.
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Biomed 261-2, Slot 505, 200 South Cedar St, Little Rock, AR 72205, USA. vvlupashin@uams.edu
Vladimir
V
Lupashin
Elizabeth
E
Sztul
D000818:Animals; D001692:Biological Transport; D006056:Golgi Apparatus / Q000378:metabolism*; D007425:Intracellular Membranes / Q000378:metabolism; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D033921:Vesicular Transport Proteins / Q000378:metabolism*
D008869:Microtubule-Associated Proteins; D033921:Vesicular Transport Proteins