Taking insult from injury: lipoxins and lipoxin receptor agonists and phagocytosis of apoptotic cells.
Phagocytic clearance of apoptotic cells plays a pivotal role in the resolution of inflammation. Recent evidence has shown that such processes can be regulated by endogenous mediators, suggesting that specific mimetics may have therapeutic potential in chronic inflammation and autoimmune disorders. Here we review the mechanisms underlying recognition and engulfment of apoptotic cells and regulation of these processes by lipoxins and lipoxin receptor agonists.
Maderna
Paola
P
Department of Medicine and Therapeutics, The Conway Institute of Biomolecular and Biomedical Research and The Dublin Molecular Medicine Centre, University College Dublin, Belfield, Dublin 4, Ireland. paola.maderna@ucd.ie
Godson
Catherine
C
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D044045:Lipoxins / Q000494:pharmacology* / Q000502:physiology; D008264:Macrophages / Q000502:physiology; D010587:Phagocytosis / Q000187:drug effects* / Q000502:physiology; D044067:Receptors, Lipoxin / Q000819:agonists* / Q000502:physiology; D015398:Signal Transduction
D000893:Anti-Inflammatory Agents; D044045:Lipoxins; D044067:Receptors, Lipoxin