Formation of lanthanide(III) texaphyrin complexes with DNA controlled by the size of the central metal cation.
Interaction of lanthanide(III) texaphyrins (LnTEX) with calf thymus DNA was studied by UV-Vis, CD, resonance light scattering spectroscopy and by laser flash photolysis. The thermal stability of the LnTEX/DNA complexes decreases with the increasing lanthanide ion radius: LuTEX>DyTEX>GdTEX>EuTEX>CeTEX> or =LaTEX. Texaphyrins LaTEX, LuTEX and GdTEX produce O2(1Deltag) in methanol solutions. In a phosphate buffer, the concentration of O2(1Deltag) produced by these texaphyrins bound to DNA is affected by the formation of aggregates on the DNA backbone.
Kubát
Pavel
P
J. Heyrovský Institute of Physical Chemistry, Academy of Sciences of the Czech Republic, Dolejskova 3, 18223 Praha 8, Czech Republic. kubat@jh-inst.cas.cz
Lang
Kamil
K
Zelinger
Zdenek
Z
Král
Vladimír
V
D000818:Animals; D002412:Cations / Q000737:chemistry; D002417:Cattle; D004247:DNA / Q000737:chemistry*; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D015394:Molecular Structure; D011166:Porphyrins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013057:Spectrum Analysis; D013696:Temperature
D002412:Cations; D028581:Lanthanoid Series Elements; D011166:Porphyrins; C442892:texaphyrin; D004247:DNA; C427203:calf thymus DNA