Mitochondrial movement and inheritance in budding yeast.
Mitochondria are essential organelles that perform fundamental cellular functions including aerobic energy mobilization, fatty acid oxidation, amino acid metabolism, heme biosynthesis and apoptosis. Mitochondria cannot be synthesized de novo. Therefore, the inheritance of this organelle is an essential part of the cell cycle; that is, daughter cells that do not inherit mitochondria will not survive. The budding yeast, Saccharomyces cerevisiae, is a facultative aerobe that can tolerate mitochondrial mutations that would be lethal in other organisms. Therefore, yeast has been used extensively to study inheritance and segregation of mitochondria. As a result, much of what we know regarding mitochondrial inheritance has been uncovered using yeast as a model system. Here, we describe the latest developments in mitochondrial motility and inheritance.
Boldogh
Istvan R
IR
Department of Anatomy and Cell Biology, Columbia University P&S 12-425, 630 West 168th Street, New York, NY 10032, USA.
Fehrenbacher
Kammy L
KL
Yang
Hyeong-Cheol
HC
Pon
Liza A
LA
D051376:Actin-Related Protein 2-3 Complex / Q000378:metabolism; D000199:Actins / Q000378:metabolism; D002455:Cell Division / Q000235:genetics / Q000502:physiology; D002950:Citrate (si)-Synthase / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics*; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D008840:Microfilament Proteins / Q000378:metabolism; D008856:Microscopy, Fluorescence; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D009154:Mutation; D018995:Myosin Heavy Chains / Q000235:genetics / Q000378:metabolism; D024701:Myosin Type V / Q000235:genetics / Q000378:metabolism; D021382:Protein Sorting Signals / Q000235:genetics; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism; D014335:Tropomyosin / Q000378:metabolism; D020691:rab GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism
C110542:ABP140 protein, S cerevisiae; D051376:Actin-Related Protein 2-3 Complex; D000199:Actins; D004272:DNA, Mitochondrial; C089419:MDM10 protein, S cerevisiae; C089418:MMM1 protein, S cerevisiae; C077512:MYO2 protein, S cerevisiae; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D008840:Microfilament Proteins; D021382:Protein Sorting Signals; D011993:Recombinant Fusion Proteins; D029701:Saccharomyces cerevisiae Proteins; D014335:Tropomyosin; C468556:Ypt11 protein, S cerevisiae; C026742:plastin; D049452:Green Fluorescent Proteins; D002950:Citrate (si)-Synthase; D024701:Myosin Type V; D018995:Myosin Heavy Chains; D020691:rab GTP-Binding Proteins