Comparison of electrophysiological models for human ventricular cells and tissues.
In this paper we briefly review currently published models for human ventricular cells and tissues. We discuss the Priebe-Beuckelmann (PB) model and the reduced version of this model constructed by Bernus et al. (redPB), the Ten Tusscher-Noble-Noble-Panfilov (TNNP) model and the Iyer-Mazhari-Winslow (IMW) model. We compare several characteristics of these models such as: sources of experimental data the models are based on, action potential morphology, action potential duration (APD) and conduction velocity (CV) restitution and computational efficiency. Finally, we discuss the application of a subset of these models-the redPB and the TNNP model-to study simulated spiral wave dynamics in 2D tissue sheets and in the human ventricles. We discuss the suitability of the different models for particular research questions and their limitations.
Theoretical Biology, University of Utrecht, Padualaan 8, 3584 CH, Utrecht, The Netherlands. khwjtuss@hotmail.com
Kirsten H W J
KH
Ten Tusscher
Olivier
O
Bernus
Rok
R
Hren
Alexander V
AV
Panfilov
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D006801:Humans; D017136:Ion Transport / Q000502:physiology*; D008955:Models, Cardiovascular; D032383:Myocytes, Cardiac / Q000502:physiology*; D016276:Ventricular Function