Chemoprevention of lung cancer: concepts and strategies.
Lung cancer develops in a stepwise fashion, with an accumulation of molecular alterations progressing through preinvasive steps to invasive disease. This progression could be arrested or reversed through pharmacologic treatments, which are known as cancer chemoprevention. Preclinical and clinical findings relating to different classes of candidate chemopreventive agents provide support for this strategy as an active and promising approach for controlling this disease.
Cohen
Victor
V
Department of Oncology, Sir Mortimer B Davis-Jewish General Hospital, McGill University School of Medicine, 3755 Cote Ste. Catherine Road, Suite E-177, Montreal, Quebec, H3T-1E2, Canada. vcohen@onc.jgh.mcgill.ca
Khuri
Fadlo R
FR
D002471:Cell Transformation, Neoplastic; D018890:Chemoprevention; D002986:Clinical Trials as Topic; D023381:Endpoint Determination; D006801:Humans; D008175:Lung Neoplasms / Q000503:physiopathology / Q000517:prevention & control*; D012307:Risk Factors