Fatal reactivation of postnatal cytomegalovirus infection with rapid emergence of ganciclovir resistance in an infant after allogeneic stem cell transplantation.
Human cytomegalovirus (HCMV) can cause serious problems after hematopoietic stem cell transplantation. The death of a pediatric transplant recipient after reactivation of a postnatal HCMV infection with bilateral retinitis and pneumonitis is described. Sequencing of the HCMV UL97 region revealed a compartment-specific mutation (H520Q) in urine conferring ganciclovir resistance.
Pediatric Bone Marrow Transplant Unit, Charité Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany. sebastian.voigt@charite.de
Sebastian
S
Voigt
Detlef
D
Michel
Olivia
O
Kershaw
Jörn-Sven
JS
Kühl
Thomas
T
Mertens
Wolfram
W
Ebell
Helga
H
Meisel
D000998:Antiviral Agents / Q000494:pharmacology; D003587:Cytomegalovirus / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D017726:Cytomegalovirus Retinitis / Q000821:virology; D017809:Fatal Outcome; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000235:genetics; D011014:Pneumonia / Q000821:virology; D014184:Transplantation, Homologous / Q000009:adverse effects*; D014775:Virus Activation
D000998:Antiviral Agents; D017853:Phosphotransferases (Alcohol Group Acceptor); C075365:ganciclovir kinase