Healing of intracranial aneurysms with bioactive coils.
Inadequate healing is an important mechanism for aneurysm development and recanalization after embolization. Matrix coils have been shown by experimental studies to enhance vascular repair and fibrosis, thus reducing the risk of recanalization. The clinical application of Matrix coils represents the transition from pure mechanical occlusion to adjunct biologic healing of aneurysms. Our preliminary clinical experience reveals evidence of a healing response in aneurysms treated with Matrix coils. This technology can be further improved through the incorporation of new knowledge on the molecular pathogenesis of aneurysms and the cellular and molecular mechanisms of healing.
Department of Radiological Sciences, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095-1721, USA. lfeng@mednet.ucla.edu
Lei
L
Feng
Fernando
F
Vinuela
Yuichi
Y
Murayama
D020341:Absorbable Implants; D019917:Blood Vessel Prosthesis Implantation / Q000145:classification / Q000295:instrumentation*; D004621:Embolization, Therapeutic; D006801:Humans; D020007:Implants, Experimental; D002532:Intracranial Aneurysm / Q000601:surgery*; D011108:Polymers
D011108:Polymers