Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis.
Chemical investigation of Santolina insularis afforded 11 germacrane sesquiterpenes (1-11), four of which (2, 3, 10, and 11) are new. The stereostructures of these compounds have been established by a combination of spectroscopic techniques (mainly NMR), chemical transformations, and application of the modified Mosher method. Compounds 8 and 10 showed a potent and selective cytotoxic activity against the human colon carcinoma cell line.
Appendino
Giovanni
G
Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, Italy.
Aviello
Gabriella
G
Ballero
Mauro
M
Borrelli
Francesca
F
Fattorusso
Ernesto
E
Petrucci
Francesca
F
Santelia
Federico U
FU
Taglialatela-Scafati
Orazio
O
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007558:Italy; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D045788:Sesquiterpenes, Germacrane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism
D000972:Antineoplastic Agents, Phytogenic; D045788:Sesquiterpenes, Germacrane