Pineapple juice labeled with gadolinium: a convenient oral contrast for magnetic resonance cholangiopancreatography.
The aim of our study was to prepare in vitro a pineapple juice (PJ) solution labeled with a minimal gadolinium concentration working as a negative contrast agent in heavily T2-weighted imaging and to assess that solution in vivo as a negative oral contrast agent for magnetic resonance cholangiopancreatography (MRCP). Three PJs were compared in vitro according to their T2. Increasing concentrations of gadolinium (Gd)-DOTA in PJ were assessed in vitro for T2 reduction. Single-shot turbo spin echo T2-weighted MR cholangiopancreatograms were obtained for 35 patients with suspected biliopancreatic duct disease, before and after ingestion of the PJ/Gd-DOTA solution. Signal intensity (SI) measurements of gastroduodenal lumens, pancreatobiliary ducts, and image quality scores were obtained systematically before and after contrast ingestion. The in vitro selected Gd-DOTA concentration in the PJ was 2.76 mmol/l. Ingestion of 180 ml of PJ labeled with 1 ml of Gd-DOTA eliminated efficiently the gastroduodenal SI in MRCP, improving significantly the rates of complete visualization of the pancreatobiliary ducts (P<0.01) and the MRCP image quality scores (P<0.05). All patients easily ingested the contrast solution and found the solution palatable. PJ labeled with gadolinium constituted an efficient and convenient negative oral contrast agent for MRCP.
Coppens
Emmanuel
E
Department of Radiology, Division of Magnetic Resonance, Hôpital Erasme, Université Libre de Bruxelles, 808 route de Lennik, 1070, Brussels, Belgium. emcoppen@ulb.ac.be
Metens
Thierry
T
Winant
Catherine
C
Matos
Celso
C
D000284:Administration, Oral; D031230:Ananas; D001628:Beverages; D049448:Cholangiopancreatography, Magnetic Resonance / Q000379:methods*; D003135:Common Bile Duct / Q000000981:diagnostic imaging / Q000378:metabolism; D003287:Contrast Media / Q000008:administration & dosage* / Q000378:metabolism; D004386:Duodenum / Q000000981:diagnostic imaging / Q000378:metabolism; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D006500:Hepatic Duct, Common / Q000000981:diagnostic imaging / Q000378:metabolism; D006571:Heterocyclic Compounds / Q000008:administration & dosage* / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009126:Muscle Relaxation / Q000187:drug effects; D009942:Organometallic Compounds / Q000008:administration & dosage* / Q000378:metabolism; D010183:Pancreatic Ducts / Q000000981:diagnostic imaging / Q000378:metabolism; D028321:Plant Preparations; D011856:Radiographic Image Enhancement; D015203:Reproducibility of Results; D013270:Stomach / Q000000981:diagnostic imaging
D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D028321:Plant Preparations; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate