Foxl2 gene and the development of the ovary: a story about goat, mouse, fish and woman.
In this review, we describe recent results concerning the genetics of sex determination in mammals. Particularly, we developed the study of the FOXL2 gene and its implication in genetic anomalies in goats (PIS mutation) and humans (BPES). We present the expression of FOXL2 in the ovaries of different species.
Equipe Sexualité et Reproduction, INRA-SCRIBE, Département PHASE, Campus de Beaulieu, 35042 Rennes Cedex, France. ellous@cochin.inserm.fr
Daniel
D
Baron
Frank
F
Batista
Stéphane
S
Chaffaux
Julie
J
Cocquet
Corinne
C
Cotinot
Edmond
E
Cribiu
Elfride
E
De Baere
Elfride
E
De Baeree
Yann
Y
Guiguen
Francis
F
Jaubert
Eric
E
Pailhoux
Maëlle
M
Pannetier
Daniel
D
Vaiman
Bernard
B
Vigier
Reiner
R
Veitia
Marc
M
Fellous
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D012734:Disorders of Sex Development; D005260:Female; D005399:Fishes; D000074842:Forkhead Box Protein L2; D051858:Forkhead Transcription Factors; D018507:Gene Expression Regulation, Developmental; D006041:Goats; D006801:Humans; D008297:Male; D051379:Mice; D010053:Ovary / Q000196:embryology* / Q000378:metabolism; D019849:Sex Determination Processes; D013045:Species Specificity; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; C421604:FOXL2 protein, human; D000074842:Forkhead Box Protein L2; D051858:Forkhead Transcription Factors; C498893:Foxl2 protein, mouse; D014157:Transcription Factors