Broader distribution of plasmid-mediated quinolone resistance in the United States.
The plasmid-encoded quinolone resistance gene qnrA confers low-level quinolone resistance, facilitating selection of higher-level resistance. Epidemiologic surveys for qnrA were extended to isolates of Enterobacter spp. and to quinolone-susceptible Enterobacteriaceae. Two (10%) of 20 ceftazidime-resistant quinolone-susceptible Klebsiella pneumoniae strains carried the gene, as did 12 (17%) of 71 ceftazidime-resistant Enterobacter strains from across the United States. One of these Enterobacter isolates was quinolone susceptible. Thus, qnrA is present in quinolone-resistant and quinolone-susceptible Enterobacter and Klebsiella strains in the United States.
Robicsek
A
A
Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114-2696, USA.
Sahm
D F
DF
Strahilevitz
J
J
Jacoby
G A
GA
Hooper
D C
DC
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D016972:Enterobacter cloacae / Q000187:drug effects / Q000235:genetics; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000235:genetics; D004756:Enterobacteriaceae Infections / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D007710:Klebsiella Infections / Q000453:epidemiology / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000235:genetics; D010957:Plasmids / Q000235:genetics*; D015363:Quinolones / Q000494:pharmacology*; D014481:United States / Q000453:epidemiology
D000890:Anti-Infective Agents; D001426:Bacterial Proteins; C485385:Qnr protein, Klebsiella pneumoniae; D015363:Quinolones