Association of the G-463A myeloperoxidase polymorphism with infection in sickle cell anemia.
Infections constitute a principal cause of morbidity and mortality in sickle cell anemia (SCA). Here we present evidence to suggest that a polymorphism (G-463A MPO) in the gene encoding the myeloperoxidase (MPO) enzyme, important for the host defense system, may significantly increase susceptibility to infection in SCA.
Raimundo N P
RN
Costa
Nicola
N
Conran
Dulcineia M
DM
Albuquerque
Paulo H
PH
Soares
Sara T O
ST
Saad
Fernando Ferreira
FF
Costa
D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000235:genetics* / Q000382:microbiology*; D002648:Child; D020022:Genetic Predisposition to Disease; D006801:Humans; D007239:Infections / Q000235:genetics; D008875:Middle Aged; D009195:Peroxidase / Q000235:genetics*; D011110:Polymorphism, Genetic
D009195:Peroxidase