Amphiphile-induced tubular budding of the bilayer membrane.
Amphiphile-induced tubular budding of the erythrocyte membrane was studied using transmission electron microscopy. No chiral patterns of the intramembraneous particles were found, either on the cylindrical buds, or on the tubular nanoexovesicles. In agreement with these observations, the tubular budding may be explained by in-plane ordering of anisotropic membrane inclusions in the buds where the difference between the principal membrane curvatures is very large. In contrast to previously reported theories, no direct external mechanical force is needed to explain tubular budding of the bilayer membrane.
Institute of Biophysics, Faculty of Medicine, University of Ljubljana, Lipiceva 2, 1000 Ljubljana, Slovenia.
Veronika
V
Kralj-Iglic
Henry
H
Hägerstrand
Peter
P
Veranic
Kristijan
K
Jezernik
Blaz
B
Babnik
Dorit R
DR
Gauger
Ales
A
Iglic
D048429:Cell Size; D002478:Cells, Cultured; D003198:Computer Simulation; D004910:Erythrocyte Membrane / Q000737:chemistry* / Q000502:physiology / Q000648:ultrastructure*; D006801:Humans; D008051:Lipid Bilayers / Q000737:chemistry*; D008560:Membrane Fluidity; D008955:Models, Cardiovascular; D008956:Models, Chemical; D008968:Molecular Conformation; D013501:Surface-Active Agents / Q000737:chemistry*
D008051:Lipid Bilayers; D013501:Surface-Active Agents