Auditory brain-stem, middle- and long-latency evoked potentials in mild cognitive impairment.
OBJECTIVE
Mild cognitive impairment (MCI) is a selective episodic memory deficit in the elderly with a high risk of Alzheimer's disease. The amplitudes of a long-latency auditory evoked potential (P50) are larger in MCI compared to age-matched controls. We tested whether increased P50 amplitudes in MCI were accompanied by changes of middle-latency potentials occurring around 50 ms and/or auditory brain-stem potentials.


METHODS
Auditory evoked potentials were recorded from age-matched controls (n = 16) and MCI (n = 17) in a passive listening paradigm at two stimulus presentation rates (2/s, 1/1.5 s). A subset of subjects also received stimuli at a rate of 1/3 s.


RESULTS
Relative to controls, MCI subjects had larger long-latency P50 amplitudes at all stimulus rates. Significant group differences in N100 amplitude were dependent on stimulus rate. Amplitudes of the middle-latency components (Pa, Nb, P1 peaking at approximately 30, 40, and 50 ms, respectively) did not differ between groups, but a slow wave between 30 and 49 ms on which the middle-latency components arose was significantly increased in MCI. ABR Wave V latency and amplitude did not differ significantly between groups.


CONCLUSIONS
The increase of long-latency P50 amplitudes in MCI reflects changes of a middle-latency slow wave, but not of transient middle-latency components. There was no evidence of group difference at the brain-stem level.


CONCLUSIONS
Increased slow wave occurring as early as 50 ms may reflect neurophysiological consequences of neuropathology in MCI.
Department of Neurology, Institute for Brain Aging and Dementia, University of California, Irvine, CA 92627, USA.
R
R
Irimajiri
E J
EJ
Golob
A
A
Starr
D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology; D001933:Brain Stem / Q000502:physiology*; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000503:physiopathology*; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory; D005260:Female; D006801:Humans; D008297:Male