Cellular replicative capacity correlates primarily with species body mass not longevity.
Although the limited replicative capacity of human fibroblasts in culture is frequently used as a model for aging, a question of major interest is whether the relationship between in vitro fibroblast proliferative capacity and species longevity is primary or secondary to a relationship with species body size. In this report we establish that body mass is the primary correlative of proliferative potential rather than species life-span.
The Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA.
Antonello
A
Lorenzini
Maria
M
Tresini
Steven N
SN
Austad
Vincent J
VJ
Cristofalo
D000293:Adolescent; D000328:Adult; D000818:Animals; D049628:Body Size; D001835:Body Weight / Q000502:physiology*; D002460:Cell Line; D049109:Cell Proliferation; D016922:Cellular Senescence / Q000502:physiology*; D005347:Fibroblasts / Q000502:physiology*; D006801:Humans; D008136:Longevity / Q000502:physiology*; D008875:Middle Aged; D013045:Species Specificity