[Effects of dopamine on cellular and humoral immune responses in septic patients].
In vitro and in vivo studies have demonstrated that apart from its hemodynamic action dopamine can modulate immune responses. Dopamine reduces the synthesis of proinflammatory and induces the synthesis of anti-inflammatory mediators. Dopamine inhibits neurohormone synthesis, lymphocyte proliferation and platelet aggregation. It reduces the phagocytic activity of neutrophils and induces apoptosis. Particularly with regard to sepsis, where high serum dopamine levels are reached by enhanced endogenous production, exogenous application and impaired clearance, this immunomodulation may have a clinical impact. This review summarizes dopamine-mediated immunomodulating effects to advance the knowledge regarding dopamine as an immune regulator under septic conditions.
Beck
G
G
Institut für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum, Mannheim. grietje.beck@anaes.ma.uni-heidelberg.de
Hanusch
C
C
Brinkkoetter
P
P
Rafat
N
N
Schulte
J
J
van Ackern
K
K
Yard
B
B
D000818:Animals; D000917:Antibody Formation / Q000502:physiology*; D002316:Cardiotonic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D049109:Cell Proliferation / Q000187:drug effects; D004298:Dopamine / Q000494:pharmacology / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007111:Immunity, Cellular / Q000502:physiology*; D007155:Immunologic Factors; D018836:Inflammation Mediators; D008214:Lymphocytes / Q000187:drug effects; D018377:Neurotransmitter Agents / Q000096:biosynthesis; D010587:Phagocytosis / Q000187:drug effects; D018805:Sepsis / Q000188:drug therapy* / Q000276:immunology*
D002316:Cardiotonic Agents; D007155:Immunologic Factors; D018836:Inflammation Mediators; D018377:Neurotransmitter Agents; D004298:Dopamine