Regulative effect of traditional Chinese medicine on gene-expression related to precancerous lesion of gastric cancer.
The gene-expression changes related with precancerous lesion of gastric cancer (PLGC) are surveyed. Not only the regulative effect of traditional Chinese medicine (TCM) on oncogene, antioncogene and anti-apoptosis gene that are related with PLGC is analyzed, but also current research state is presented. It's showed that TCM has effects of therapy and inversion on PLGC. These effects are related with the inhibition to related oncogene expression, the regulation and activation to the deletion of antioncogene, the inhibition to the high-expression of mutant gene-protein about antioncogene, and the regulative function to anti-apoptosis gene.
Zhu
Fang-shi
FS
Zhejiang University, Sir Run Run Shaw Hospital of College Medicine, Hangzhou, China. zhufs@tom.com
Si
Jian-min
JM
D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D015870:Gene Expression; D006801:Humans; D008516:Medicine, Chinese Traditional; D009857:Oncogenes; D011230:Precancerous Conditions / Q000235:genetics*; D013274:Stomach Neoplasms