Differentiation of CD8 T cells in response to acute and chronic viral infections: implications for HIV vaccine development.
Successful HIV vaccine strategies will likely require the induction of robust cellular immune responses, in addition to strong humoral responses. Unfortunately, there is no clear molecular definition of an effective HIV-specific CD8 T cell response. In this review, we discuss the differentiation of CD8 T cells in response to acute and chronic viral infections. We then apply concepts derived from these studies to predict the desirable characteristics of HIV-specific CD8 T cell memory.
Miller
J D
JD
Emory Vaccine Center, Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Masopust
D
D
Wherry
E J
EJ
Kaech
S
S
Silvestri
G
G
Ahmed
R
R
D016915:AIDS Vaccines / Q000276:immunology*; D000208:Acute Disease; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation; D002908:Chronic Disease; D006801:Humans; D007156:Immunologic Memory; D014611:Vaccination; D014777:Virus Diseases / Q000276:immunology*
D016915:AIDS Vaccines