Efficacy and safety of chunghyul-dan (qingwie-dan) in patients with hypercholesterolemia.
Chunghyul-dan has inhibitory effects on HMG-CoA reductase and pancreatic lipase. We investigated whether Chunghyul-dan has therapeutic effects on humans with hypercholesterolemia. This study was a case-control, open-labeled clinical study. Subjects were treated with Chunghyul-dan (600 mg/day) or Atorvastatin (10 mg/day) for 8 weeks. Serum lipids were checked at baseline after 4 and 8 weeks of medication. While, Chunghyul-dan showed significant lipid-lowering effects, it was less effective than Atorvastatin. In comparison with the histological controls, Chunghyul-dan's effects were superior to placebo. On safety assessment, there was no adverse effect with the use of Chunghyul-dan in hepatic or renal toxicity. In conclusion, we suggest that Chunghyul-dan is a useful herbal medicine for hypercholesterolemia.
Cho
Ki Ho
KH
Department of Cardiovascular and Neurologic Diseases (Stroke Center) College of Oriental Medicine, Kyung-Hee University, Korea.
Kang
Heung Sun
HS
Jung
Woo Sang
WS
Park
Seong Uk
SU
Moon
Sang Kwan
SK
D000328:Adult; D000368:Aged; D000924:Anticholesteremic Agents / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use*; D000069059:Atorvastatin; D004365:Drugs, Chinese Herbal / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006538:Heptanoic Acids / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011758:Pyrroles / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome
D000924:Anticholesteremic Agents; C499382:Chunghyuldan; D004365:Drugs, Chinese Herbal; D006538:Heptanoic Acids; D010919:Placebos; D011758:Pyrroles; D000069059:Atorvastatin