Processing of Japanese morphogram and syllabogram in the left basal temporal area: electrical cortical stimulation studies.
Language functions in the left basal temporal area (LBTA) were investigated using electrical cortical stimulation during functional mapping in six Japanese patients with refractory epilepsy. This study provides the first direct evidence that kana (Japanese syllabogram) is processed in the LBTA. Electrical stimulation of some areas within LBTA induced disturbance in overt reading of kana words only in the first trials, with no errors in the subsequent trials. By contrast, stimulation of the same area caused obvious disturbance in kana non-word reading in all trials. Since a kana word carries both meaning and sound while a kana non-word carries only sounds of a letter string, the contrasting results of partial and complete disturbance imply a possibility that there are two distinct pathways for kana reading: one dealing with both phonological and semantic aspects of the words and the other dealing only with phonological aspect. Kanji words (Japanese morphogram) and objects/pictures were found to be processed in an area different from the area for the kana non-word processing. Furthermore, the present study also identified the common area for processing kanji reading and object/picture naming. There were no errors in matching pictures with kanji words, indicating that concepts of pictures and meanings of kanji words were not interfered by the electrical stimulation of that area. The new insight provides a clue for partial description of processing pathways for language-related visual information in LBTA. Three types of information (morphological, phonological, and semantic) are conveyed together at some stages and are separated into different routes at some other stages.
Usui
Keiko
K
Human Brain Research Center, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
Ikeda
Akio
A
Takayama
Motohiro
M
Matsuhashi
Masao
M
Satow
Takeshi
T
Begum
Tahamina
T
Kinoshita
Masako
M
Miyamoto
Susumu
S
Hashimoto
Nobuo
N
Nagamine
Takashi
T
Fukuyama
Hidenao
H
Shibasaki
Hiroshi
H
D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D001931:Brain Mapping; D004558:Electric Stimulation / Q000009:adverse effects / Q000379:methods*; D004833:Epilepsy, Temporal Lobe / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007564:Japan / Q000453:epidemiology / Q000208:ethnology; D007802:Language; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008960:Models, Psychological; D010364:Pattern Recognition, Visual / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods; D011581:Psychological Tests / Q000706:statistics & numerical data; D013702:Temporal Lobe / Q000473:pathology / Q000503:physiopathology* / Q000528:radiation effects*