The IGF-1--IGFBPs system in the crevicular fluid: its changes during orthodontic movement.
IGF-1 (Insulin-like growth factor-1) is a growth factor whose biological activity at cellular level is regulated by 6 binding proteins (IGFBs); one of them, IGFBP-3, is the most abundant in blood. Both IGF-1 and IGFBP-3 are expressed by bone cells and may be important factors in bone remodelling (1-5). The aims of this study were to evaluate the presence of IGF-1 and IGFBP-3 in crevicular fluid and to assess whether their levels changed during orthodontic tooth movement in patients under orthodontic treatment. Orthodontic movement alters alveolar bone remodelling. Changes in the amounts of IGF-1 and IGFBP-3 in crevicular fluid may reflect changes in alveolar bone remodelling.
Department of Neuroscience, Section of Odontostomatology, University of Pisa, Pisa, Italy. rinaldina77@hotmail.com
Rinaldina
R
Saggese
Giovanni
G
Federico
Paola
P
Gandini
D000293:Adolescent; D000539:Alveolar Process / Q000378:metabolism; D016723:Bone Remodeling / Q000502:physiology*; D002648:Child; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000096:biosynthesis*; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis*; D008297:Male; D014087:Tooth Movement Techniques
D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I