HRPT2, a tumor suppressor gene for hyperparathyroidism-jaw tumor syndrome.
Hyperparathyroidism-jaw tumor (HPT-JT) syndrome is a familial multi-tumor syndrome resulting from inactivating mutations in the HRPT2 tumor suppressor gene, which encodes a protein product named parafibromin. Here, we will review recent advances in genetic and protein studies on parafibromin, and examine its biological functions.
Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick Avenue NE, Grand Rapids, MI 49503, USA.
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Wang
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Tan
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Zhang
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Morreau
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Teh
D049109:Cell Proliferation; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006961:Hyperparathyroidism / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D007573:Jaw Neoplasms / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D013577:Syndrome; D025521:Tumor Suppressor Proteins / Q000235:genetics* / Q000378:metabolism
C454900:CDC73 protein, human; D025521:Tumor Suppressor Proteins