Evolving endosomes: how many varieties and why?
The cell biologist's insight into endosomal diversity, in terms of both form and function, has increased dramatically in the past few years. This understanding has been promoted by the availability of powerful new techniques that allow imaging of both cargo and machinery in the endocytic process in real time, and by our ability to inhibit components of this machinery by RNA interference. The emerging picture from these studies is of a highly complex, dynamic and adaptable endosomal system that interacts at various points with the secretory system of the cell.
Margaret Dyson Vision Research Institute, LC-300, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.
Emilie
E
Perret
Aparna
A
Lakkaraju
Sylvie
S
Deborde
Ryan
R
Schreiner
Enrique
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Rodriguez-Boulan
D000818:Animals; D003599:Cytoskeleton / Q000378:metabolism; D011992:Endosomes / Q000145:classification* / Q000378:metabolism*; D008563:Membrane Lipids / Q000378:metabolism; D021381:Protein Transport
D008563:Membrane Lipids