Design in silico, synthesis and binding evaluation of a carbohydrate-based scaffold for structurally novel inhibitors of matrix metalloproteinases.
Magnetic Resonance Center (CERM) and Department of Agricultural Biotechnology (DIBA), University of Florence, Via Sacconi 6, 50019 Sesto Fiorentino FI, Italy.
Marco
M
Fragai
Cristina
C
Nativi
Barbara
B
Richichi
Chiara
C
Venturi
D001667:Binding, Competitive; D003198:Computer Simulation; D018360:Crystallography, X-Ray; D015195:Drug Design; D006020:Glycopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008024:Ligands; D053508:Matrix Metalloproteinase 12; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000737:chemistry*; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship
D006020:Glycopeptides; D008024:Ligands; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases; D008666:Metalloendopeptidases; D053508:Matrix Metalloproteinase 12