[Antinecrotic and antiischemic effect of mexidol and trental in ischemia of the skin graft].
Antinecrotic activity of 2-ethyl-6-methyl-3 oxipyridin succinate (mexidol) and pentoxifylline (trental) was investigated on 32 mail rats with average body-weight of 170-220 g. Under the influence of mexidol and trental, which were injected 15 min before the insection of skin graft and then once per day during 3 days, necrotized area of skin graft is reduced by 22 and 15%, the amount of lost keranocytes--by 33 and 30%. In skin graft homogenates under the influence of mexidol rises the reduced under ischemia succinate dehydrogenase activity, while under trental influence it does not change. Under the influence of mexidol and trental on third day content of ATP rises by 29,5 and 19,5 %, ADP increases and decreases by 27%, creatinphosphate--by 33 and 21% correspondingly. Trentale improves elasticity of erythrocytes. It is suggested, that positive effect of mexidol on skin graft is conditioned by its ability to activate succinate-dependent detour in oxygen phosphorilation chain of mitochondries and to raise content of ubiquinone, whereas the effect of trental relates with intensification of microcirculation, delivery of oxygen on periphery. That allows recommending combined use of preparations in ischemia of skin.
Acad. N.V. Karsanov Republican Centre of Medical Biophysics and Introduction of New Biomedical Technologies, Georgia.
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Gorelasvili
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Antelava
D000244:Adenosine Diphosphate / Q000032:analysis; D000255:Adenosine Triphosphate / Q000032:analysis; D000818:Animals; D042963:Electron Transport Complex II / Q000032:analysis; D006085:Graft Survival / Q000187:drug effects*; D007511:Ischemia / Q000473:pathology; D015603:Keratinocytes / Q000187:drug effects; D008297:Male; D009336:Necrosis / Q000473:pathology; D010431:Pentoxifylline / Q000494:pharmacology*; D010725:Phosphocreatine / Q000032:analysis; D010847:Picolines / Q000494:pharmacology*; D051381:Rats; D012867:Skin / Q000098:blood supply* / Q000166:cytology; D016038:Skin Transplantation / Q000473:pathology*; D013524:Surgical Flaps / Q000473:pathology*
D010847:Picolines; D010725:Phosphocreatine; C070020:emoxypine succinate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D042963:Electron Transport Complex II; D010431:Pentoxifylline