Bacteria-host-cell interactions at the plasma membrane: stories on actin cytoskeleton subversion.
Exploitation of the host-cell actin cytoskeleton is pivotal for many microbial pathogens to enter cells, to disseminate within and between infected tissues, to prevent their uptake by phagocytic cells, or to promote intimate attachment to the cell surface. To accomplish this, these pathogens have evolved common as well as unique strategies to modulate actin dynamics at the plasma membrane, which will be discussed here, exemplified by a number of well-studied bacterial pathogens.
Cytoskeleton Dynamics Group, German Research Center for Biotechnology, Mascheroder Weg 1, D-38124 Braunschweig, Germany.
Klemens
K
Rottner
Theresia E B
TE
Stradal
Juergen
J
Wehland
D000199:Actins / Q000378:metabolism*; D000818:Animals; D001419:Bacteria / Q000378:metabolism* / Q000472:pathogenicity; D001422:Bacterial Adhesion / Q000502:physiology; D001424:Bacterial Infections / Q000378:metabolism / Q000382:microbiology; D018407:Bacterial Physiological Phenomena; D002462:Cell Membrane / Q000378:metabolism / Q000382:microbiology*; D003599:Cytoskeleton / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D016023:Integrins / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000502:physiology; D010587:Phagocytosis; D051317:Wiskott-Aldrich Syndrome Protein, Neuronal
D000199:Actins; D016023:Integrins; D009419:Nerve Tissue Proteins; C495771:WASL protein, human; D051317:Wiskott-Aldrich Syndrome Protein, Neuronal