[Behavioral changes of rats under rotation stimulation].
OBJECTIVE
To assess the specification and efficiency of rotation sickness indices by monitoring changes of behaviors in rats under rotation stimulation.


METHODS
SD rats were stimulated by Crampton model with different time courses. Pica or kaolin consumption (KC), conditioned taste aversion (CTA) or saccharine water ingestion (SWI), 2 h food ingestion (2hFI), and open-field test (OFT) scores were observed.


RESULTS
Apparent changes of the four indices were observed after rotation stimulation. SWI, OFT scores and 2hFI decreased exponentially with increase of duration of the motion stimulation. KC increased linearly with the increase of time within 12 h stimulation. After 18 h stimulation, KC decreased to a level even lower than that after 6 or 12 h stimulation. The adjusted correlation between changes of the indices and duration of stimulation within 12 h are: 0.94 for KC, 0.54 for SWI, 0.44 for 2hFI and 0.34 for OFT. The maximum efficiency of the four indices appeared at 6-hour stimulation: 70% for KC, 90% for SWI, 80% for 2hFI and 95% for OFT.


CONCLUSIONS
It is found that pica and CTA were more specific than the other indices. They may serve as primary indices and can be combined with the secondary indices such as 2hFI or OFT. Six hours is the optimal duration of stimulation by Crampton model for rotation sickness studies.
Cai
Yi-ling
YL
Department of Military Hygiene, The Second Military Medical University, Shanghai, China.
Ma
Wen-ling
WL
Li
Min
M
Ouyang
Ru-ying
RY
Hu
Liang
L
Sun
Ya-lin
YL
D000818:Animals; D001348:Aversive Therapy; D001522:Behavior, Animal; D004195:Disease Models, Animal; D004435:Eating; D007616:Kaolin; D009041:Motion Sickness / Q000503:physiopathology / Q000517:prevention & control*; D010842:Pica; D051381:Rats; D017207:Rats, Sprague-Dawley; D012399:Rotation; D012439:Saccharin; D013649:Taste; D013997:Time Factors; D014867:Water; D018474:Weightlessness Simulation
D014867:Water; D007616:Kaolin; D012439:Saccharin