[KID syndrome: pathogenesis of ocular lesions].
KID is a rare ectodermal syndrome of unknown etiology. It is characterized by vascular keratitis (K), congenital ichthyosis (I) and neurosensorial deafness (D). We report the cases of three patients with KID syndrome who all had typical vascular keratitis responsible for photophobia and impaired visual acuity, and severe meibomian dysfunction associated with hyperkeratotic lid borders. The authors believe that meibomian dysfunction plays an important role in the pathogenesis of ocular lesions. Consequently, patients were treated with oral minocycline, topical steroids and artificial tears. This treatment proved to significantly reduce ocular discomfort.
Service d'Ophtalmologie, Groupe Hospitalier Bichat-Claude Bernard, Paris.
R
R
Tabet
J
J
Smadja
T
T
Hoang-Xuan
D000328:Adult; D002648:Child; D003638:Deafness; D005128:Eye Diseases / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D007057:Ichthyosis; D007634:Keratitis; D008297:Male; D008875:Middle Aged; D020795:Photophobia / Q000175:diagnosis / Q000209:etiology; D013577:Syndrome; D014786:Vision Disorders / Q000175:diagnosis / Q000209:etiology; D014792:Visual Acuity