[Review: genetics of familial dilated cardiomyopathy].
Dilated cardiomyopathy is the most frequent cardiomyopathy. Twenty to 35% of dilated cardiomyopathies are familial. The transmission of the disease is most frequently dominant autosomic. Dilated cardiomyopathy is genetically heterogeneous. Hence, mutations have been identified on 14 genes, and 9 loci have been associated to familial dilated cardiomyopathy. The incriminated mechanisms in the pathogeny of dilated cardiomyopathy include mutations on proteins of the sarcomere, the cytosqueletton, the nuclear membrane or involved in calcium signaling. This review indicates the genes and proteins implicated in the pathogeny of familial dilated cardiomyopathy, and their potential clinical effects.
Service de cardiologie, CHI Le Raincy-Montfermeil, 10, rue du Général-Leclerc, 93370 Montfermeil, France. walamara@yahoo.fr
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Amara
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Villard
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Komajda
D002118:Calcium / Q000378:metabolism; D002311:Cardiomyopathy, Dilated / Q000235:genetics* / Q000503:physiopathology*; D003599:Cytoskeleton; D020022:Genetic Predisposition to Disease; D006801:Humans; D040582:Inheritance Patterns; D009154:Mutation; D009685:Nuclear Envelope; D010375:Pedigree; D012518:Sarcomeres
D002118:Calcium