Naturally arising CD25+CD4+ regulatory T cells in tumor immunity.
Naturally arising regulatory T (TR) cells, represented by CD25+CD4+ TR cells, play an essential role in maintaining immunological self-tolerance. This T cell-mediated dominant control of the immune response not only inhibits the development of autoimmune disease, but also impedes effective immunosurveillance against autologous tumor cells. Attenuation of TR cell-mediated immune suppression can therefore evoke effective tumor immunity in otherwise nonresponsive animals. This common regulatory mechanism for autoimmunity and tumor immunity can be exploited when devising a novel immunotherapy for cancer.
Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, 53 Shogoin-Kawahara-Cho, Sakyo-Ku, Kyoto 606-8507, Japan.
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Sakaguchi
D000818:Animals; D015551:Autoimmunity; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D007109:Immunity; D009369:Neoplasms / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D015375:Receptors, Interleukin-2