[Changes of somatostatin (SS) in stomach and duodenum of rats after +Gz exposure].
OBJECTIVE
To study effects of +Gz exposure on the change of somatostatin (SS) in stomach and duodenum of rats.


METHODS
Forty male Wistar rats were randomly divided into +1 Gz control group, +5 Gz x 5 min group, +10 Gz x 5 min group and repeated exposure [(+5 Gz x 2 min) + (+10 Gz x 2 min) + (+5 Gz x 2 min)] group. After +Gz exposure, the rats in each group were anesthesized by aether, and gastric and duodenal mucosa were taken immediately. Levels of SS were assayed using radioimmunoassay (RIA) methods.


RESULTS
Gastric and duodenal mucosa of the control group and +5 Gz group were intact and smooth. Under naked eye and light microscope, scattered hemorrhagic spoto, small ulcers, submucosal hyperemia, and erosion of mucosa were found in gastric antrum and duodenum in +10 Gz group rats. Diffuse hyperemia, erosion and small ulcers were found in mucosa of gastric fundus, gastric antrum and duodenum of repeated exposure group. Exposure to +Gz can increase somatostatin content in gastric antrum and duodenum (P<0.01).


CONCLUSIONS
Increase of SS content may play an important role in the prevention of pathogenesis of stomach and duodenum after +G exposure.
Zhong
Xue-jun
XJ
Department of Gastroenterology, Jinan Shangdong, China.
Wu
Zhan-jun
ZJ
Sun
Yan-ping
YP
Xu
Gang
G
Xu
Kui-gao
KG
Tian
Guang-qing
GQ
D000054:Acceleration; D000818:Animals; D004386:Duodenum / Q000378:metabolism / Q000473:pathology; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology*; D018471:Hypergravity; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000378:metabolism*
D013004:Somatostatin