Synthesis and ocular effects of imidazole nitrolic acids.
Novel 1-R-imidazole-2-nitrolic acids and 1-R-imidazole-5-nitrolic acids (R: H, Me, Bn) were synthesized from oximes by treatment with a mixture of fuming nitric acid and acetic acid. The effects of these potential nitric oxide-donating compounds were tested on ocular variables such as intraocular pressure and formation of cyclic guanosine-3,5'-monophosphate in the incubation of porcine iris-ciliary body.
Oresmaa
Larisa
L
Department of Chemistry, University of Joensuu, Joensuu, Finland. Larisa.Oresmaa@joensuu.fi
Kotikoski
Hanna
H
Haukka
Matti
M
Salminen
Johanna
J
Oksala
Olli
O
Pohjala
Esko
E
Moilanen
Eeva
E
Vapaatalo
Heikki
H
Vainiotalo
Pirjo
P
Aulaskari
Paula
P
D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects / Q000502:physiology*; D006152:Cyclic GMP / Q000378:metabolism; D015195:Drug Design; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D007498:Iris / Q000187:drug effects / Q000502:physiology; D008958:Models, Molecular; D015394:Molecular Structure; D009566:Nitrates / Q000378:metabolism; D009573:Nitrites / Q000378:metabolism; D005996:Nitroglycerin / Q000138:chemical synthesis* / Q000494:pharmacology*; D013552:Swine
D007093:Imidazoles; D009566:Nitrates; D009573:Nitrites; D005996:Nitroglycerin; D006152:Cyclic GMP