Alicyclic beta-amino acids in Medicinal Chemistry.
The structural element of alicyclic beta-amino acids shows some remarkable biological effects: For some 5- and 6-membered beta-amino acids a unique anti fungal activity has been observed, 7-membered beta-amino acid derivatives have been investigated for neurological disorders. The application of 5-, 6- and 7-membered alicyclic beta-amino acids in Medicinal Chemistry will be reported. [structure: see text]
Kuhl
A
A
Medicinal Chemistry, Business Group Pharma, Bayer Health Care AG, Wuppertal, Germany.
Hahn
M G
MG
Dumić
M
M
Mittendorf
J
J
D000598:Amino Acids, Cyclic / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry; D002491:Central Nervous System Agents / Q000737:chemistry; D003515:Cycloleucine / Q000031:analogs & derivatives / Q000138:chemical synthesis; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000598:Amino Acids, Cyclic; D000935:Antifungal Agents; D002491:Central Nervous System Agents; D050483:Dopamine Plasma Membrane Transport Proteins; D003515:Cycloleucine; C065594:cispentacin