Partial-breast radiation for early staged breast cancers: hypothesis, existing data, and a planned phase III trial.
This review of clinical data from partial-breast treatment studies discusses results from a single institution's experience using brachytherapy catheters, the MammoSite balloon (Proxima Company, Alpharetta, GA), and three-dimensional external beam partial-breast treatment. Rationale, techniques, dose schedules, and available results are presented. Intra-operative single-dose radiation to the lumpectomy site is also reviewed. The National Surgical Adjuvant Breast and Bowel Project (NSABP) and Radiation Therapy Oncology Group (RTOG) cooperative groups are opening a phase III trial to compare partial-breast treatment to the standard 5- to 6-week course of whole-breast radiation. The design of this study is also presented in this review.
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA. mccormib@mskcc.org
Beryl
B
McCormick
D001918:Brachytherapy / Q000295:instrumentation; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy*; D017326:Clinical Trials, Phase III as Topic / Q000379:methods; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D015412:Mastectomy, Segmental / Q000379:methods; D009367:Neoplasm Staging; D011878:Radiotherapy / Q000379:methods*