A novel, expeditious synthesis of racemic camptothecin.
[reaction: see text] A novel and efficient synthesis of racemic camptothecin, starting from a readily accessible hydroxy pyridone, is presented. Key steps include a Claisen rearrangement of a functionalized allylic ether, a hindered Heck coupling, and a Friedländer condensation.
Anderson
Regan J
RJ
Université Joseph Fourier de Grenoble, Chimie Recherche (LEDSS), France.
Raolji
Gajendra B
GB
Kanazawa
Alice
A
Greene
Andrew E
AE
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry; D029769:Camptotheca / Q000737:chemistry; D002166:Camptothecin / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D013237:Stereoisomerism
D000972:Antineoplastic Agents, Phytogenic; D002166:Camptothecin