Antibacterial caged-tetraprenylated xanthones from the fruits of Garcinia hanburyi.
A new caged-tetraprenylated xanthone, hanburinone (1), was isolated from the fresh fruits of Garcinia hanburyi together with four known caged-tetraprenylated xanthones; isomoreollin B (2), morellin (3), moreollic acid (4) and morellic acid (5). Their structures were elucidated by analysis of spectroscopic data and comparison of the NMR data with those reported previously. Compounds 4 and 5 showed moderately antibacterial activity against methicillin-resistant Staphylococcus aureus with a MIC value of 25 microg/ml.
Department of Chemistry, Faculty of Science, Prince of Songkla University, Songkhla, Thailand.
Yaowapa
Y
Sukpondma
Vatcharin
V
Rukachaisirikul
Souwalak
S
Phongpaichit
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029760:Garcinia / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D044004:Xanthones