Additive effects of plant sterol and stanol esters to statin therapy.
Plant sterol and stanol esters each have similar additive effects in lowering low-density lipoprotein cholesterol when combined with statins. They differ in that plasma plant sterols increase when plant sterol esters are used for this purpose, especially in patients with familial hypercholesterolemia, but decrease when plant stanol esters are used.
Department of Metabolic Medicine, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom. g.thompson@imperial.ac.uk
Gilbert R
GR
Thompson
D008078:Cholesterol, LDL / Q000378:metabolism; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000188:drug therapy*; D010840:Phytosterols / Q000494:pharmacology* / Q000627:therapeutic use*; D008517:Phytotherapy; D016032:Randomized Controlled Trials as Topic; D012855:Sitosterols / Q000494:pharmacology* / Q000627:therapeutic use*; D016896:Treatment Outcome
D008078:Cholesterol, LDL; D010840:Phytosterols; D012855:Sitosterols; C407042:plant stanol ester