Development of a stepwise [3 + 3] annelation to functionalized piperidines.
[reaction: see text] A stepwise formal [3 + 3] cycloaddition sequence via a Grignard addition-cyclization reaction leads to a much improved piperidine synthesis. This methodology provides improved flexibility in both the aziridine substrate and TMM equivalent.
Department of Chemistry, University of Sheffield, Brook Hill, UK.
Katharine M
KM
Goodenough
Piotr
P
Raubo
Joseph P A
JP
Harrity