Induction of apoptosis by a novel indirubin-5-nitro-3'-monoxime, a CDK inhibitor, in human lung cancer cells.
A novel indirubin analog, indirubin-5-nitro-3'-monoxime, inhibited cell proliferation against various human cancer cells. Additional studies indicate that the mechanism of action of this analog against human lung cancer cells might be to arrest cell cycle progression at the G2/M phase and induce apoptosis via p53- and mitochondria-dependent pathways. These data suggest that indirubin-5-nitro-3'-monoxime might be a novel candidate for development of anticancer agents.
Lee
Jong-Won
JW
College of Pharmacy, Ewha Womans University, 11-1 Daehyun-dong, Seodaemun-ku, Seoul 120-750, Republic of Korea.
Moon
Myoung Ju
MJ
Min
Hye-Young
HY
Chung
Hwa-Jin
HJ
Park
Eun-Jung
EJ
Park
Hyen Joo
HJ
Hong
Ji-Young
JY
Kim
Yong-Chul
YC
Lee
Sang Kook
SK
D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors*; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology; D007399:Interphase / Q000187:drug effects; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013329:Structure-Activity Relationship
D000903:Antibiotics, Antineoplastic; D007211:Indoles; D018844:Cyclin-Dependent Kinases; C027185:indirubin