Gender effects in dietary histidine-induced anorexia.
OBJECTIVE
Histamine, a derivative of histidine, decreases food intake by activation of histamine neurons. The aim of the present study was to clarify gender-related differences in food intake through the histidine-histamine neuron system.


METHODS
Male, female, and ovariectomized rats were fed a histidine-enriched diet or a control diet with the cafeteria method.


RESULTS
The suppressive effect of histidine on food intake was greater in female rats than in male rats, and the suppressive effect of histidine on food intake was less in ovariectomized rats than in female rats.


CONCLUSIONS
Our results indicate that females are more sensitive than males to dietary histidine-induced anorexia.
Kasaoka
Seiichi
S
Department of Health and Nutrition, Bunkyo University Women's College, Kanagawa, Japan. kasaoka@shonan.bunkyo.ac,jp
Kawahara
Yumi
Y
Inoue
Setsuko
S
Tsuji
Makiko
M
Kato
Hideo
H
Tsuchiya
Takahide
T
Okuda
Hiromichi
H
Nakajima
Shigeru
S
D000818:Animals; D000855:Anorexia / Q000139:chemically induced* / Q000378:metabolism; D002149:Energy Intake / Q000187:drug effects*; D005260:Female; D006632:Histamine / Q000378:metabolism; D006639:Histidine / Q000008:administration & dosage* / Q000378:metabolism / Q000633:toxicity*; D008297:Male; D023421:Models, Animal; D009765:Obesity / Q000517:prevention & control; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D012737:Sex Factors
D006639:Histidine; D006632:Histamine