CD14 C-159T and early infection with Pseudomonas aeruginosa in children with cystic fibrosis.
Early acquisition of Pseudomonas aeruginosa is associated with a poorer prognosis in patients with cystic fibrosis. We investigated whether polymorphisms in CD14, the lipopolysaccharide receptor, increase the risk of early infection. Forty-five children with cystic fibrosis were investigated with annual bronchoalveolar lavage (BAL) and plasma sCD14 levels. Plasma sCD14 levels were significantly lower in children from whom P.aeruginosa was subsequently isolated (492.75 microg/ml vs. 1339.43 microg/ml, p = 0.018). Those with the CD14 -159CC genotype had a significantly increased risk of early infection with P.aeruginosa suggesting that CD14 C-159T plays a role in determining the risk of early infection with P.aeruginosa.
School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia 6001. andrew.martin@health.wa.gov.au
A C
AC
Martin
I A
IA
Laing
G
G
Zhang
S
S
Brennan
K
K
Winfield
P D
PD
Sly
S M
SM
Stick
J
J
Goldblatt
P N
PN
LeSouef
D001315:Australia / Q000453:epidemiology; D002648:Child; D015331:Cohort Studies; D015897:Comorbidity; D003550:Cystic Fibrosis / Q000453:epidemiology* / Q000235:genetics*; D004252:DNA Mutational Analysis; D018572:Disease-Free Survival; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D015994:Incidence; D018950:Lipopolysaccharide Receptors / Q000235:genetics*; D008297:Male; D018410:Pneumonia, Bacterial / Q000453:epidemiology* / Q000235:genetics*; D011379:Prognosis; D011552:Pseudomonas Infections / Q000453:epidemiology* / Q000235:genetics*; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors
D018950:Lipopolysaccharide Receptors