Biooxidation of (+)-catechin and (-)-epicatechin into 3,4-dihydroxyflavan derivatives by the endophytic fungus Diaporthe sp. isolated from a tea plant.
The microbial transformation of (+)-catechin (1) and (-)-epicatechin (2) by endophytic fungi isolated from a tea plant was investigated. It was found that the endophytic filamentous fungus Diaporthe sp. transformed them (1, 2) into the 3,4-cis-dihydroxyflavan derivatives, (+)-(2R,3S,4S)-3,4,5,7,3',4'-hexahydroxyflavan (3) and (-)-(2R,3R,4R)-3,4,5,7,3',4'-hexahydroxyflavan (7), respectively, whereas (-)-catechin (ent-1) and (+)-epicatechin (ent-2) with a 2S-phenyl group resisted the biooxidation.
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Hiroshima, Japan. shibuya@fupharm.fukuyama-u.ac.jp
Hirotaka
H
Shibuya
Andria
A
Agusta
Kazuyoshi
K
Ohashi
Shoji
S
Maehara
Partomuan
P
Simanjuntak
D001203:Ascomycota / Q000737:chemistry*; D002392:Catechin / Q000737:chemistry*; D005419:Flavonoids / Q000138:chemical synthesis*; D010084:Oxidation-Reduction; D013662:Tea / Q000382:microbiology*
C505184:3,4-dihydroxyflavan; D005419:Flavonoids; D013662:Tea; D002392:Catechin