Destroying gadofullerene aggregates by salt addition in aqueous solution of Gd@C(60)(OH)(x) and Gd@C(60)[C(COOH(2))](10).
A combined proton relaxivity and dynamic light scattering study has shown that aggregates formed in aqueous solution of water-soluble gadofullerenes can be disrupted by addition of salts. The salt content of fullerene-based materials will strongly influence properties related to aggregation phenomena, therefore, their behavior in biological or medical applications. In particular, the relaxivity of gadofullerenes decreases dramatically with phosphate addition. Moreover, real biological fluids present a rather high salt concentration which will have consequences on fullerene aggregation and influence fullerene-based drug delivery.
Laus
Sabrina
S
Laboratoire de Chimie Inorganique et Bioinorganique, Ecole Polytechnique Fédérale de Lausanne, EPFL-BCH, CH-1015 Lausanne, Switzerland.
Sitharaman
Balaji
B
Tóth
Eva
E
Bolskar
Robert D
RD
Helm
Lothar
L
Asokan
Subashini
S
Wong
Michael S
MS
Wilson
Lon J
LJ
Merbach
André E
AE
D003287:Contrast Media / Q000737:chemistry*; D037741:Fullerenes / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry*; D006878:Hydroxides / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry*; D012492:Salts / Q000737:chemistry* / Q000494:pharmacology; D014867:Water / Q000737:chemistry
D003287:Contrast Media; D037741:Fullerenes; D006878:Hydroxides; D009942:Organometallic Compounds; D012492:Salts; D014867:Water; C031356:hydroxide ion; D005682:Gadolinium