New bicyclic taxane diterpenoids from Taxus sumatrana.
Investigation of an acetone extract of the leaves and twigs of Taxus sumatrana has resulted in the isolation of two new bicyclic taxoids, tasumatrols M (1), and N (2) and a new baccatin III derivative, tasumatrol O (3) together with the previous known 7-deacetylcanadensene (4) and 2alpha,7beta,13alpha-triacetoxy-5alpha,9alpha-dihydroxy-2(3-->20) abeotaxa-4(20),11-dien-10-one. The structures of these taxanes were established on the basis of spectroscopic analyses, especially 1- and 2D NMR, and chemical derivatization.
Shen
Ya-Ching
YC
Institute of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China. ycshen@mail.nsysu.edu.tw
Hsu
Shaw-Man
SM
Lin
Yun-Sheng
YS
Cheng
Kuen-Ching
KC
Chien
Ching-Te
CT
Chou
Chang-Hung
CH
Cheng
Yuan-Bin
YB
D001643:Bridged Bicyclo Compounds / Q000737:chemistry / Q000302:isolation & purification*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D043823:Taxoids / Q000737:chemistry / Q000302:isolation & purification*; D020946:Taxus / Q000737:chemistry*
D001643:Bridged Bicyclo Compounds; D004224:Diterpenes; D043823:Taxoids