[Population pharmacokinetics of carbamazepine in adults with epilepsy].
The aim of the present study was to determinate the factors affecting carbamazepine (CBZ) clearance (CL) in adults with epilepsy using a mixed-effect model and sparse data collected during routine clinical care. The patient population comprised 104 adults receiving CBZ. A total of 161 CBZ steady state serum concentration samples were analyzed. Population CL was calculated by using NONMEM with a one compartment model with first-order absorption and elimination. The following covariates were tested for their influence on clearance (CL): total body weight, age, dose/day, sex, surface area (SA) and comedication with primidone (PRIM), ualproic acid or phenytoin (DFH). The final regression model for carbamazepine clearance found best to describe the data was: CL = (0.614 SA + 0.0016 dose/day)(1 + 0.278 DFH)(1 + 0.326 PRIM).
Facultad de Ciencias Químicas, UASLP. srm@uaslp.mx
Silvia
S
Romano-Moreno
Eréndida Lizbeth
EL
Medina-Rojas
Ana Luisa
AL
Salas-Ortiz
Juan Manuel
JM
Vargas-Morales
José Trinidad
JT
Pérez-Urizar
Idelfonso
I
Rodríguez-Leyva
D000293:Adolescent; D000328:Adult; D002220:Carbamazepine / Q000493:pharmacokinetics*; D004827:Epilepsy / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
D002220:Carbamazepine