Effect of Mesua ferrea Linn. flower extract on Salmonella.
Based on its traditional uses in folk medicine, the whole flower extract of Mesua ferrea Linn. was tested for its in vitro antimicrobial efficacy against five different strains of Salmonella spp. All the strains were found to be highly sensitive to the extract, MIC of the extract against each organism being 50 microg/ml. The extract was tested in vitro for its mode of antibacterial activity against S. Typhimurium NCTC 74 and it was found to be bactericidal in action. In vivo studies of this extract offered significant protection to Swiss albino mice at doses approximately 2 and 4 mg/mouse when challenged with 50 median lethal dose of S. Typhimurium NCTC 74. Further, the extract caused statistically significant reduction in viable count of the strain in liver, spleen and heart blood of challenged mice.
Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra 835 215, India. rupa_mazumder@rediffmail.com
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R
Mazumder
Sujata G
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Dastidar
S P
SP
Basu
Avijit
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Mazumder
D000818:Animals; D000890:Anti-Infective Agents; D028084:Clusiaceae / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000382:microbiology; D066298:In Vitro Techniques; D008099:Liver / Q000382:microbiology; D051379:Mice; D010936:Plant Extracts; D018514:Plant Structures / Q000378:metabolism*; D012480:Salmonella Infections / Q000188:drug therapy*; D012481:Salmonella Infections, Animal / Q000188:drug therapy*; D012486:Salmonella typhimurium / Q000378:metabolism*; D013154:Spleen / Q000382:microbiology; D013234:Stem Cells; D014774:Virulence
D000890:Anti-Infective Agents; D010936:Plant Extracts