Future of early detection of lung cancer: the role of mouse models.
Early detection represents one of the most promising approaches to improving lung cancer survival. To date, no screening strategies have been shown to decrease mortality from the disease. Furthermore, no reliable circulating biomarkers of lung cancer have been identified that allow early diagnosis. With the advent of gene targeting technology, new genetically engineered mouse models of lung cancer closely recapitulate the pathobiology of human disease. These mouse models have enabled novel approaches to early detection, including the identification of cancer-associated serum markers using proteomic technologies and the development of new molecular imaging tools. The application of innovative technologies to accurate mouse models promises to accelerate the discovery of new molecular targets and imaging biomarkers for the early detection of lung cancer.
Shaw
Alice T
AT
Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. ashaw1@partners.org
Kirsch
David G
DG
Jacks
Tyler
T
D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis*; D003952:Diagnostic Imaging / Q000662:veterinary; D004195:Disease Models, Animal; D005818:Genetic Engineering; D008175:Lung Neoplasms / Q000235:genetics* / Q000503:physiopathology / Q000662:veterinary*; D051379:Mice
D014408:Biomarkers, Tumor