Modulation of dendritic cell maturation and function by B lymphocytes.
Investigating the signals that regulate the function of dendritic cells (DC), the sentinels of the immune system, is critical to understanding the role of DC in the regulation of immune responses. Accumulating lines of evidence indicate that in addition to innate stimuli and T cell-derived signals, B lymphocytes exert a profound regulatory effect in vitro and in vivo on the Ag-presenting function of DC. The identification of B cells as a cellular source of cytokines, chemokines, and autoantibodies that are critically involved in the process of maturation, migration, and function of DC provides a rationale for immunotherapeutic intervention of autoimmune and inflammatory conditions by targeting B cells. Conversely, efficient cross-presentation of Ags by DC pulsed with immune complexes provides an alternative approach in the immunotherapy of cancer and infectious diseases.
The Edward Jenner Institute for Vaccine Research, Berkshire, United Kingdom. jagadeesh.bayry@jenner.ac.uk
Jagadeesh
J
Bayry
Sébastien
S
Lacroix-Desmazes
Michel D
MD
Kazatchkine
Olivier
O
Hermine
David F
DF
Tough
Srini V
SV
Kaveri
D000818:Animals; D017951:Antigen Presentation; D000936:Antigen-Antibody Complex / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology*; D002450:Cell Communication; D002454:Cell Differentiation; D018925:Chemokines / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000166:cytology* / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D016756:Immunoglobulins, Intravenous / Q000494:pharmacology; D066298:In Vitro Techniques; D051379:Mice; D011961:Receptors, Fc / Q000378:metabolism; D015398:Signal Transduction
D000936:Antigen-Antibody Complex; D018925:Chemokines; D016207:Cytokines; D016756:Immunoglobulins, Intravenous; D011961:Receptors, Fc