Mutator effects in Escherichia coli caused by the expression of specific foreign genes.
Certain genes from Lactococcus lactis and Pseudomonas aeruginosa, including the nfxB gene, generate a mutator phenotype in Escherichia coli. The results of this study, together with those of a previous study, support conservation of regulatory sequences in E. coli and P. aeruginosa and suggest that some efflux pumps prevent mutagenicity by exporting mutagenic products of metabolism.
Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, 90095, USA.
Vanessa
V
Gabrovsky
Mitsuko Lynn
ML
Yamamoto
Jeffrey H
JH
Miller
D001483:Base Sequence; D003001:Cloning, Molecular; D017931:DNA Primers; D004269:DNA, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D016254:Mutagenesis, Insertional; D016133:Polymerase Chain Reaction; D011550:Pseudomonas aeruginosa / Q000235:genetics*; D015183:Restriction Mapping
D017931:DNA Primers; D004269:DNA, Bacterial