[Mechanisms of cytostasis and metastasis].
TGFbeta signaling controls a plethora of cellular responses in human development and disease. Recent cellular, biochemical, and structural studies have revealed significant insight into the mechanisms of the activation of TGFbeta receptors, the receptor-mediated activation of Smad transcription factors, the Smad-mediated regulation of target gene expression, and the negative control of the cell cycle by these signals. Loss of TGFbeta cytostatic responsiveness and gain of metastastic activity are common alterations of this pathway in cancer. The analysis of these normal and altered states is providing new insights into physiology, pathology and therapy.
Joan
J
Massagué Solé
D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D006801:Humans; D009362:Neoplasm Metastasis / Q000473:pathology*; D016212:Transforming Growth Factor beta / Q000502:physiology*
D016212:Transforming Growth Factor beta