Intracerebroventricular self-administration of commonly abused anabolic-androgenic steroids in male hamsters (Mesocricetus auratus): nandrolone, drostanolone, oxymetholone, and stanozolol.
Previous studies by the authors have shown voluntary intracerebroventricular (icv) testosterone self-administration in hamsters (Mesocricetus auratus). Here, the authors compared icv self-administration of 4 anabolic steroids (drostanolone, nandrolone, oxymetholone, and stanozolol) at 0.1, 1.0, and 2.0 microg/microl, each for 8 days. Males (n=8/group) showed the highest levels of operant behavior for injectable steroids (drostanolone, nandrolone) compared with orally active androgens (oxymetholone, stanozolol). For nandrolone, responses on the active and inactive nose-pokes averaged 22.3 +/- 4.6/4 hr and 10.7 +/- 2.0/4 hr, respectively. Responding for drostanolone was similar. Males self-administering oxymetholone or stanozolol did not prefer the active nose-poke. These data demonstrate that injectable androgens are more reinforcing than oral steroids.
Ballard
Cortney L
CL
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Wood
Ruth I
RI
D000704:Analysis of Variance; D000728:Androgens / Q000008:administration & dosage*; D000732:Androstanols / Q000008:administration & dosage; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003216:Conditioning, Operant / Q000187:drug effects*; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D004333:Drug Administration Routes; D005106:Exploratory Behavior / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D009277:Nandrolone / Q000008:administration & dosage; D010110:Oxymetholone / Q000008:administration & dosage; D012054:Reinforcement, Psychology; D012646:Self Administration / Q000379:methods; D013197:Stanozolol / Q000008:administration & dosage; D019966:Substance-Related Disorders / Q000503:physiopathology*; D013997:Time Factors
D000728:Androgens; D000732:Androstanols; D013197:Stanozolol; D009277:Nandrolone; C100263:dromostanolone; D010110:Oxymetholone