[The effect of alcoxyglycerols, squalene and n-3 fatty acid on some innate immunity parameters in healthy people].
BioMarine 570 is well tolerated agent supporting the innate immunity. It was isolated from Greenland shark liver.


OBJECTIVE
To evaluate the effect of BioMarine.


METHODS
The 10 healthy, randomly chosen volunteers are included to the protocol. Volunteers are given 9 capsules of BioMarine a day for 30 days. The clinical and laboratory parameters were analyzed before and after the treatment. The following innate immunity parameters were analyzed: C1q, C3 C4 and CH50 of complement level, CD4/CD8 ratio, Th1/Th2 cytokine polarization, reactive oxygen intermediates production (ROI).


RESULTS
Clinically no side effects were noted. BioMarine intake has increased the C1q level, increase CD4/CD8 ratio from 1.3 to 1.8 and polarized Th1/Th2 lymphocyte cytokine secretion towards Th1. The modulation of ROI production by neutrophils was also noted. BioMarine has no affect on CD4+CD25+ regulatory lymphocytes.


CONCLUSIONS
Concluding BioMarine is save, effective and innate immunity supporting agent, can be effectively applied in people with disturbed immune system as harmless and effective agent normalizing the immune imbalance.
Henryk
Tchórzewski
T
Zakład Immunologii Klinicznej Instytutu Centrum Zdrowia Matki Polki w Lodzi. natalewk@wp.pl
Ewa
Głowacka
G
Małgorzata
Banasik
B
Przemysław
Lewkowicz
L
D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000187:drug effects; D016516:CD4-CD8 Ratio; D019587:Dietary Supplements; D004338:Drug Combinations; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D005260:Female; D005990:Glycerol / Q000494:pharmacology*; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D013185:Squalene / Q000494:pharmacology*; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects
D015703:Antigens, CD; D004338:Drug Combinations; D015525:Fatty Acids, Omega-3; D013185:Squalene; D005990:Glycerol