Duration of rheumatoid arthritis influences the degree of functional improvement in clinical trials.
BACKGROUND
Functional capacity is an important outcome in rheumatoid arthritis and is generally measured using the Health Assessment Questionnaire disability index (HAQ). Functional limitation incorporates both activity and damage. Because irreversible damage increases over time, the HAQ may be less likely to show improvement in late than in early rheumatoid arthritis.


OBJECTIVE
To determine the relation between sensitivity to change of the HAQ and duration of rheumatoid arthritis in reports of clinical trials.


METHODS
Data were pooled from clinical trials that measured responses of HAQ scores at three or six months. The effect size of the HAQ was calculated and linear regression used to predict the effect size by duration of rheumatoid arthritis at group level. Treatment effect was adjusted for by including the effect sizes of pain scores and of tender joint counts as additional independent variables in separate models. Subgroup analysis employed contemporary regimens (methotrexate, leflunomide, combination therapies, and TNF inhibitors) only.


RESULTS
36 studies with 64 active treatment arms and 7628 patients (disease duration 2.5 months to 12.2 years) were included. The effect sizes of the HAQ decreased by 0.02 for each additional year of mean disease duration using all trials, and by 0.04/year in the subgroup analysis (p<or=0.01 for both analyses, except for pain adjusted models at three months).


CONCLUSIONS
In individual trials, less improvement in the HAQ might be expected in late than in early rheumatoid arthritis. Comparison of changes in HAQ among rheumatoid arthritis trials should take into consideration the disease stage of the treated groups.
Aletaha
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Intramural Research Program, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA. aletahad@mail.nih.gov
Ward
M M
MM
D000328:Adult; D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000503:physiopathology; D002986:Clinical Trials as Topic; D003625:Data Collection; D003627:Data Interpretation, Statistical; D018450:Disease Progression; D005500:Follow-Up Studies; D006306:Health Surveys; D006801:Humans; D007596:Joints / Q000503:physiopathology; D016014:Linear Models; D008875:Middle Aged; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome
D018501:Antirheumatic Agents