The impact of vaccines and the future of genetically modified poxvirus vaccines for poultry.
The regular use of live or killed vaccines against infectious agents has remarkably improved the efficiency of poultry production. In some cases eradication of disease has been possible when the pathogen is antigenically stable and confined to a certain geographical area. In other instances monovalent or polyvalent live or killed vaccines have been effective in reducing mortality and morbidity. Many conventional vaccines are developed by trial and error and basic information about their genetic make-up is not known. While the poultry industry has benefited from the regular use of conventional vaccines, there is need for a new generation of effective vaccines that require minimal handling of birds during administration. Using molecular techniques, it is possible to identify the genes associated with virulence and protection. In genetically engineered vaccines, genes that encode protective antigens can be expressed in bacterial or viral vectors. In this regard, avianpox virus vectors appear to be promising for the generation of polyvalent vaccines expressing antigens from multiple pathogens.
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61802, USA. tripathy@ux1.cso.uiuc.edu
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Tripathy
D000818:Animals; D005818:Genetic Engineering / Q000662:veterinary; D011200:Poultry; D011201:Poultry Diseases / Q000517:prevention & control*; D011212:Poxviridae / Q000235:genetics / Q000276:immunology*; D011213:Poxviridae Infections / Q000517:prevention & control / Q000662:veterinary*; D014611:Vaccination / Q000639:trends / Q000662:veterinary*; D014613:Vaccines, Attenuated; D014765:Viral Vaccines
D014613:Vaccines, Attenuated; D014765:Viral Vaccines