In vitro and in vivo bactericidal activities of vancomycin dispersed in porous biodegradable poly(epsilon-caprolactone) microparticles.
Treatment of methicillin-resistant Staphylococcus aureus osteomyelitis requires a prolonged antibiotic therapy with vancomycin. Because of its weak diffusion, the in situ implantation of vancomycin could be interesting. The activity of vancomycin encapsulated in microparticles was evaluated in vitro and in vivo on rabbit osteomyelitis and showed a good activity compared to intravenous administration.
Le Ray
Anne-Marie
AM
Centre de Recherche sur les Matériaux d'Intérêt Biologique, Equipe INSERM 99-03, UFR Odontologie, University of Nantes, 1 rue Gaston Veil, 44035 Nantes, France.
Gautier
Hélène
H
Laty
Marie-Katel
MK
Daculsi
Guy
G
Merle
Christian
C
Jacqueline
Cédric
C
Hamel
Antoine
A
Caillon
Jocelyne
J
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000494:pharmacology; D002208:Caproates / Q000494:pharmacology*; D015169:Colony Count, Microbial; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D007783:Lactones / Q000494:pharmacology*; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests / Q000379:methods; D010019:Osteomyelitis / Q000188:drug therapy* / Q000382:microbiology; D011817:Rabbits; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D014640:Vancomycin / Q000008:administration & dosage / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D002208:Caproates; D003692:Delayed-Action Preparations; D007783:Lactones; C121056:caprolactone; D014640:Vancomycin