Chronic venous abnormalities in symptomatic and asymptomatic protein C deficiency.
BACKGROUND
Thrombophilia is a frequent medical condition associated with symptomatic deep vein thrombosis (DVT). Unlike other clinical risk factors associated with DVT, such as surgery, thrombophilia has not been demonstrated to be associated with asymptomatic venous thrombotic events. Our aim was to search for asymptomatic sequelae of DVT in a protein C (PC)-deficient family.


METHODS
We studied 228 individuals from a large kindred with PC deficiency and performed a systematic ultrasound examination.


RESULTS
Among the 203 patients without a known history of venous thrombosis we found seven patients with abnormalities indicative of prior asymptomatic thrombosis: six (7.4%) in the PC-deficient group (n = 81) and only one (0.8%) in the non-deficient group (n = 122). The relative risk for these sequelae associated with PC deficiency was 9.0 (95% CI: 1.1-73.7).


CONCLUSIONS
These data suggest that chronic venous abnormalities are frequently present and that thrombotic events in asymptomatic individuals with familial PC deficiency may be underestimated.
University of Paris 5 and INSERM U428, Paris, France.
J
J
Emmerich
C Y
CY
Vossen
P W
PW
Callas
C
C
Demers
S
S
Naud
G L
GL
Long
P
P
Couture
F R
FR
Rosendaal
E G
EG
Bovill
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D005192:Family Health; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010641:Phenotype; D011486:Protein C / Q000235:genetics; D020151:Protein C Deficiency / Q000150:complications* / Q000175:diagnosis*; D011655:Pulmonary Embolism / Q000150:complications / Q000175:diagnosis; D012306:Risk; D019851:Thrombophilia / Q000150:complications / Q000175:diagnosis; D013927:Thrombosis; D014463:Ultrasonography; D020246:Venous Thrombosis / Q000150:complications* / Q000175:diagnosis
D011486:Protein C