Spontaneous resolution of hemophagocytic syndrome and disseminated intravascular coagulation associated with parvovirus b19 infection in a previously healthy child.
A 10-year-old male with a brain abscess developed pancytopenia, liver dysfunction, disseminated intravascular coagulation (DIC) and decrease of immunoglobulin A (IgA) level during postoperative antibiotic and anticonvulsant therapy. A bone marrow examination revealed hemophagocytosis. Real-time PCR revealed parvovirus B19 infection. The hemophagocytic syndrome resolved without specific treatment. To our knowledge, this is the first report of a spontaneous resolution of parvovirus B19-associated hemophagocytic syndrome and DIC.
Kaya
Zühre
Z
Department of Pediatric Hematology, Gazi University Medical School, Ankara, Turkey. zuhre_kaya@yahoo.com
Oztürk
Gülyüz
G
Gürsel
Türkiz
T
Bozdayi
Gülendam
G
D002648:Child; D004211:Disseminated Intravascular Coagulation / Q000821:virology*; D015616:Histiocytosis, Non-Langerhans-Cell / Q000821:virology*; D006801:Humans; D008297:Male; D010322:Parvoviridae Infections / Q000150:complications*; D016732:Parvovirus B19, Human; D012075:Remission, Spontaneous