Recent advances using rodent models for predicting human allergenicity.
The potential allergenicity of newly introduced proteins in genetically engineered foods has become an important safety evaluation issue. However, to evaluate the potential allergenicity and the potency of new proteins in our food, there are still no widely accepted and reliable test systems. The best-known allergy assessment proposal for foods derived from genetically engineered plants was the careful stepwise process presented in the so-called ILSI/IFBC decision tree. A revision of this decision tree strategy was proposed by a FAO/WHO expert consultation. As prediction of the sensitizing potential of the novel introduced protein based on animal testing was considered to be very important, animal models were introduced as one of the new test items, despite the fact that non of the currently studied models has been widely accepted and validated yet. In this paper, recent results are summarized of promising models developed in rat and mouse.
Knippels
Léon M J
LM
Experimental Immunology, TNO Nutrition and Food Research, Department Toxicology and Applied Pharmacology, P.O. Box 360, 3700 AJ Zeist, The Netherlands. Knippels@voeding.tno.nl
Penninks
André H
AH
D000284:Administration, Oral; D000485:Allergens / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D023421:Models, Animal; D051381:Rats
D000485:Allergens; D007074:Immunoglobulin G; D007073:Immunoglobulin E