Self-administering cannabinoids.
Endocannabinoids, which are typically released by principal cells in response to prolonged depolarization, act as retrograde messengers to inhibit synaptic transmission. A recent study shows that in a specific subtype of cortical interneuron, endocannabinoids released under similar circumstances can also act cell-autonomously. Here, endocannabinoids endow these neurons with a memory of their own activity in the form of a long-term change in excitability.
Neurosciences Graduate Program and Division of Biology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0357, USA.
Lindsey L
LL
Glickfeld
Massimo
M
Scanziani
D000818:Animals; D019898:Autocrine Communication / Q000187:drug effects / Q000502:physiology; D063385:Cannabinoid Receptor Modulators / Q000502:physiology*; D002186:Cannabinoids / Q000008:administration & dosage*; D009474:Neurons / Q000502:physiology; D012646:Self Administration; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
D063385:Cannabinoid Receptor Modulators; D002186:Cannabinoids