Anti-babesial compounds from Curcuma zedoaria.
Anti-babesial activity was confirmed in an extract of the bark of Curcuma zedoaria. The active ingredients were isolated, and their chemical structures were determined to be zedoalactones A, B, and C based on spectral data. Zedoalactone C is a hitherto unreported compound. The IC50 vales of these active compounds against Babesia gibsoni were compared with a standard drug, diminazene aceturate. The IC50 value of diminazene aceturate was 0.6 microg/mL, while those of zedoalactones A, B, and C were 16.5, 1.6 and 4.2 microg/mL, respectively.
Laboratory of Bioorganic Chemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan.
Ken
K
Kasahara
Shinkichi
S
Nomura
Subeki
Hideyuki
H
Matsuura
Masahiro
M
Yamasaki
Osamu
O
Yamato
Yoshimitsu
Y
Maede
Ken
K
Katakura
Mamoru
M
Suzuki
Trimurningsih
Chairul
Teruhiko
T
Yoshihara
D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001403:Babesia / Q000187:drug effects*; D001404:Babesiosis / Q000188:drug therapy; D030024:Curcuma; D006801:Humans; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000981:Antiprotozoal Agents; D010936:Plant Extracts