[Regulation of hematopoiesis by the osteoblastic niche].
Blood cell production is maintained throughout the lifetime of an individual by hematopoietic stem cells (HSCs). Interaction of HSCs with their particular microenvironments, known as stem cell niches, is critical for maintaining the stem cell properties, including self-renewal capacity and the ability of differentiation into single or multiple lineages. Recently, it was clarified that a osteoblast is a critical component of the niche for HSCs. HSCs keep balance between quiescence and cell division/proliferation in the osteoblastic niche. The HSC specific properties are dynamically controlled by the signalings of receptors/ligands and cell adhesion molecules produced by osteoblasts.
Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University.
Fumio
F
Arai
D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D010006:Osteoblasts / Q000502:physiology*