Movement in ribosome translocation.
Translocation of peptidyl-tRNA and mRNA within the ribosome during protein synthesis is promoted by the elongation factor EF-G and by the hydrolysis of GTP. A new study reports that EF-G binds to ribosomes as an EF-G.GDP complex and that GTP is exchanged for GDP on the ribosome. Together with cryo-electron microscopy, this unexpected finding helps clarify the role of GTP in translocation.
Fraser
Christopher S
CS
Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, CA 947020, USA.
Hershey
John W B
JW
D006153:Guanosine Diphosphate / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000378:metabolism; D009068:Movement; D010441:Peptide Chain Elongation, Translational; D020653:Peptide Elongation Factor G / Q000235:genetics / Q000378:metabolism*; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism; D012343:RNA, Transfer / Q000378:metabolism; D012270:Ribosomes / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure
D020653:Peptide Elongation Factor G; D012333:RNA, Messenger; D006153:Guanosine Diphosphate; D006160:Guanosine Triphosphate; D012343:RNA, Transfer