Pharmacological agents in development for invasive aspergillosis.
The urgent medical need for new potent antifungal agents in the management of invasive aspergillosis (IA) has resulted in the development of several compounds which may be of value in the future for the treatment or prophylaxis of IA. In the past years, several novel types of drugs have been discovered and developed, some of which are already in late-stage clinical trials and ready to enter the market. This paper discusses the antifungal agents, classified by their mode of action, that are currently available and the agents which are still in development for treatment or prevention of IA.
Department of Hospital Pharmacy, Erasmus Medical Centre, Rotterdam, The Netherlands. ruijgrok@apdz.azr.nl
Elisabeth J
EJ
Ruijgrok
Jaques F G M
JF
Meis