Effects of sanguinaria in fluoride-containing dentifrices on the remineralisation of subsurface carious lesion in vitro.
OBJECTIVE
The purpose of this study was to investigate the potential cariostatic benefits of dentifrice containing both fluoride (F) and sanguinaria (SG) in a silica abrasive formula using the microbial de- and re-mineralisation cycle model.


METHODS
Samples of bovine tooth enamel were embedded in resin, polished, exposed to a lactate carbopol buffer system for 44 hours, and divided into one control and five test groups of 12 specimens each by randomised blocks with VHN stratification. Surface microhardness was compared before and after the microbial cyclic sequences.


RESULTS
VHNs for groups treated with dentifrices containing 1,000 ppm F from MFP with or without bamboo salt (BS) were significantly higher than the control. The groups treated with dentifrices containing F from NaF/silica with or without SG had significantly higher VHNs than that with F from MFP/DCPD. The VHNs treated with dentifrice containing both NaF-SG demonstrated the highest among test groups, indicating that there may be a synergistic effect in remineralising the incipient subsurface lesion.


CONCLUSIONS
The dentifrice containing both NaF and SG showed a significantly greater effect (p < 0.05) on the remineralisation of the enamel lesion than the other test dentifrices.
Department of Preventive Dentistry, College of Dentistry, Kyungpook National University, Daegu, Korea.
Suk Jin
SJ
Hong
Seong Soog
SS
Jeong
Keun Bae
KB
Song
D000470:Alkaloids / Q000627:therapeutic use*; D000818:Animals; D053119:Benzophenanthridines; D002327:Cariostatic Agents / Q000627:therapeutic use*; D002417:Cattle; D003731:Dental Caries / Q000188:drug therapy*; D003743:Dental Enamel / Q000187:drug effects / Q000473:pathology; D044622:Dental Pellicle / Q000187:drug effects / Q000473:pathology; D003773:Dental Plaque / Q000382:microbiology; D003802:Dentifrices / Q000627:therapeutic use*; D005459:Fluorides / Q000627:therapeutic use*; D006244:Hardness; D007546:Isoquinolines; D019344:Lactic Acid / Q000494:pharmacology; D010617:Phenanthridines / Q000627:therapeutic use*; D010710:Phosphates / Q000627:therapeutic use; D011897:Random Allocation; D031681:Sanguinaria; D012969:Sodium Fluoride / Q000627:therapeutic use; D016986:Streptococcus sobrinus / Q000502:physiology; D017001:Tooth Demineralization / Q000139:chemically induced; D014089:Tooth Remineralization
D000470:Alkaloids; D053119:Benzophenanthridines; D002327:Cariostatic Agents; D003802:Dentifrices; D007546:Isoquinolines; D010617:Phenanthridines; D010710:Phosphates; C012980:fluorophosphate; D019344:Lactic Acid; D012969:Sodium Fluoride; C005705:sanguinarine; D005459:Fluorides