[Brugada syndrome].
The Brugada syndrome, first described as a new clinical entity in 1992, is characterized by ST segment elevation in right precordial leads (V1 to V3) with a high risk of sudden death. The clinical presentation of this syndrome is distinguished by a male predominance and the appearance of lethal arrhythmic events. In 1998, mutation in SCN5A, the alpha-subunit of the sodium channel, linked the etiology of this syndrome had been discovered. The proper diagnostic criteria has been proposed by the European Society of Cardiology based on the currently available clinical data of this syndrome. In the symptomatic patients often need an implantable cardioverter defibrillator (ICD) because of a high incidence of recurrence.
Department of Internal Medicine, Nippon Medical School Tama-Nagayama Hospital.
Hirotsugu
H
Atarashi
D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D016757:Death, Sudden, Cardiac; D004562:Electrocardiography; D006801:Humans; D008297:Male; D013577:Syndrome