[The efficacy of surgical and conservative methods in secondary prevention of carotid ischemic stroke].
A comparative analysis of the efficacy of surgical and conservative methods in secondary prevention of carotid ischemic stroke has been conducted in patients with clinical symptoms of acute ischemic brain lesions (carotid artery stenosis less than 70%). The results of the 3-year follow-up study revealed that carotid endarterectomua is a method of choice. Comparing to conservative therapy, it allows a reduction of the absolute risk of secondary ischemic episode development to 4% (57% for conservative therapy) and of the relative risk--to 0.07 (0.77 for conservative therapy). The necessity of antiaggregate therapy that enables increased percentage of strokes prevented is proved. Comparing to aspirin, clopidogrel is a drug of choice contributing to the regress of thrombotic layers in the cases of restenosis development in the area of sutures after the interventions using special patches.
Skvortsova
V I
VI
Lemenev
V L
VL
Akhmetov
V V
VV
Alekseeva
G S
GS
Stakhovskaia
L V
LV
Gutsaliuk
A G
AG
D000368:Aged; D001921:Brain / Q000098:blood supply / Q000601:surgery; D002545:Brain Ischemia / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control*; D016893:Carotid Stenosis / Q000150:complications* / Q000175:diagnosis / Q000601:surgery*; D002536:Cerebral Arteries / Q000000981:diagnostic imaging; D000077144:Clopidogrel; D003131:Combined Modality Therapy; D016894:Endarterectomy, Carotid / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D013524:Surgical Flaps; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D014463:Ultrasonography
D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine