LitMiner and WikiGene: identifying problem-related key players of gene regulation using publication abstracts.
The LitMiner software is a literature data-mining tool that facilitates the identification of major gene regulation key players related to a user-defined field of interest in PubMed abstracts. The prediction of gene-regulatory relationships is based on co-occurrence analysis of key terms within the abstracts. LitMiner predicts relationships between key terms from the biomedical domain in four categories (genes, chemical compounds, diseases and tissues). Owing to the limitations (no direction, unverified automatic prediction) of the co-occurrence approach, the primary data in the LitMiner database represent postulated basic gene-gene relationships. The usefulness of the LitMiner system has been demonstrated recently in a study that reconstructed disease-related regulatory networks by promoter modelling that was initiated by a LitMiner generated primary gene list. To overcome the limitations and to verify and improve the data, we developed WikiGene, a Wiki-based curation tool that allows revision of the data by expert users over the Internet. LitMiner (http://andromeda.gsf.de/litminer) and WikiGene (http://andromeda.gsf.de/wiki) can be used unrestricted with any Internet browser.
Maier
Holger
H
GSF-National Research Center for Environment and Health, Institute of Experimental Genetics, AG BIODV, Ingolstädter Landstrasse 1, D-85768 Neuherberg, Germany.
Döhr
Stefanie
S
Grote
Korbinian
K
O'Keeffe
Sean
S
Werner
Thomas
T
Hrabé de Angelis
Martin
M
Schneider
Ralf
R
D000043:Abstracting and Indexing; D005786:Gene Expression Regulation; D020407:Internet; D039781:PubMed; D012984:Software; D014584:User-Computer Interface