Neuroprotective effects of naturally occurring biflavonoids.
We examined neuroprotective effects of naturally occurring biflavonoids on oxidative stress-induced and amyloid beta peptide-induced cell death in neuronal cells. Among the nine biflavonoids tested, amentoflavone, ginkgetin, and isoginkgetin exhibited strong neuroprotection against cytotoxic insults induced by oxidative stress and amyloid beta, suggesting their therapeutic potential against neurodegenerative diseases, including ischemic stroke and Alzheimer's disease.
Kang
Sam Sik
SS
Department of Manufacturing Pharmacy, Seoul National University College of Pharmacy, Seoul 110-460, Republic of Korea.
Lee
Ji Yeon
JY
Choi
Yoo Keum
YK
Song
Sun Sook
SS
Kim
Ju Sun
JS
Jeon
Su Jin
SJ
Han
Yong Nam
YN
Son
Kun Ho
KH
Han
Byung Hee
BH
D000544:Alzheimer Disease / Q000188:drug therapy; D016229:Amyloid beta-Peptides / Q000378:metabolism / Q000494:pharmacology; D044946:Biflavonoids / Q000737:chemistry / Q000494:pharmacology*; D002545:Brain Ischemia / Q000188:drug therapy; D016923:Cell Death / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D019636:Neurodegenerative Diseases / Q000188:drug therapy; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*; D014407:Tumor Cells, Cultured
D016229:Amyloid beta-Peptides; D044946:Biflavonoids; D018696:Neuroprotective Agents