Serum lipids as protective factors for subarachnoid hemorrhage.
Identification of common serum lipid profiles in patients with subarachnoid hemorrhage (SAH) may allow a better understanding of its pathogenesis. We conducted a hospital-based case-control study in Japan. One hundred and fifty consecutive cases of spontaneous SAH during a 5-year period were examined and their lipid profiles assessed. Age- and gender-matched controls were identified for each case through random hospital sampling. Median serum total cholesterol was 161 mg/dl (range 77-288) in patients with SAH, and 209 mg/dl (134-441) in controls (p < 0.001). Median serum triglycerides were 95 mg/dl (range 28-589) in SAH and 122 mg/dl (31-371) in controls (p < 0.001). A high serum total cholesterol of more than 5.20 mmol/L (200 mg/dl) (odds ratio 0.22 [95% confidence interval 0.12-0.40]) and a high serum triglyceride of more than 1.70 mmol/L (150 mg/dl) (odds ratio 0.29 [95% CI 0.14-0.60]) were independent protective factors for SAH. In conclusion, higher values of both serum cholesterol and triglyceride may be inversely associated with the occurrence of SAH.
Tokuda
Yasuharu
Y
Department of Medicine, Okinawa Chubu Hospital, Okinawa, Japan and Harvard School of Public Health, Boston, USA. tokuyasu@orange.ocn.ne.jp
Stein
Gerald H
GH
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015984:Causality; D002784:Cholesterol / Q000097:blood; D015897:Comorbidity; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology*; D006949:Hyperlipidemias / Q000453:epidemiology*; D006973:Hypertension / Q000453:epidemiology; D007564:Japan / Q000453:epidemiology; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects; D013345:Subarachnoid Hemorrhage / Q000097:blood* / Q000453:epidemiology*; D014280:Triglycerides / Q000097:blood
D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol