Does resistance to pyrazinamide accurately indicate the presence of Mycobacterium bovis?
Mycobacterium bovis is best identified by screening those isolates of the Mycobacterium tuberculosis complex that have any pyrazinamide (PZA) resistance, using a confirmatory test such as spoligotyping, biochemical testing, or genomic deletion analysis. The sensitivity for detection of M. bovis is lowered to 82% when only PZA-monoresistant isolates are screened.
de Jong
Bouke C
BC
Division of Infectious Diseases, Stanford University, Stanford, California, USA. bouke@stanford.edu
Onipede
Anthony
A
Pym
Alex S
AS
Gagneux
Sebastien
S
Aga
Roxanne S
RS
DeRiemer
Kathryn
K
Small
Peter M
PM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000494:pharmacology*; D015373:Bacterial Typing Techniques; D002648:Child; D024881:Drug Resistance, Bacterial; D017353:Gene Deletion; D006801:Humans; D008826:Microbial Sensitivity Tests; D009163:Mycobacterium bovis / Q000145:classification* / Q000187:drug effects* / Q000235:genetics; D009841:Oligonucleotides / Q000032:analysis; D011718:Pyrazinamide / Q000494:pharmacology*; D014376:Tuberculosis / Q000382:microbiology
D000995:Antitubercular Agents; D009841:Oligonucleotides; D011718:Pyrazinamide