Acute demyelinating encephalomyelitis (ADEM), cryptococcal reactivation and disseminated Herpes simplex in an HIV infected child following HAART.
Highly active antiretroviral treatment (HAART) is increasingly becoming available for HIV infected children in South Africa. We describe a 7-year-old HIV infected child (CD4=10, viral load =180,669copies/ml) who develops a cryptococcal meningitis, with raised intracranial pressure, complicated by ADEM and disseminated Herpes simplex infection following commencement of HAART.
Department of Pediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University and Tygerberg Children's Hospital, P.O. Box 19063, Tygerberg 7505, South Africa. vtoorn@sun.ac.za
Ronald
R
van Toorn
Fiona
F
Kritzinger
Helena
H
Rabie
D000208:Acute Disease; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D002648:Child; D003454:Cryptococcus / Q000187:drug effects / Q000502:physiology; D003711:Demyelinating Diseases / Q000139:chemically induced* / Q000175:diagnosis; D004679:Encephalomyelitis / Q000139:chemically induced* / Q000175:diagnosis; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D006561:Herpes Simplex / Q000139:chemically induced*; D006801:Humans; D007427:Intracranial Pressure; D008279:Magnetic Resonance Imaging; D008297:Male; D016919:Meningitis, Cryptococcal / Q000139:chemically induced* / Q000503:physiopathology; D019562:Viral Load; D014775:Virus Activation