Increased temporal lobe gyrification in preterm children.
Preterm birth often results in significant learning disability, and previous magnetic resonance imaging (MRI) studies of preterm children have demonstrated reduction in overall cortical tissue with particular vulnerability in the temporal lobe. We measured cortical gyrification in 73 preterm and 33 term control children at 8 years of age and correlated these findings with tests of language ability to determine the associations among preterm birth, neurodevelopment and functional outcome. Preterm children demonstrated significantly increased bilateral temporal lobe gyrification index compared to term controls. Left temporal gyrification index was significantly negatively correlated with left temporal lobe gray matter volume as well as reading recognition scores in the preterm group. Cortical development in the temporal lobe appears to be differentially vulnerable to preterm birth.
Stanford Psychiatry Neuroimaging Laboratory, Stanford University School of Medicine, Stanford, CA 94305-5719, USA. skesler@stanford.edu
Shelli R
SR
Kesler
Betty
B
Vohr
Karen C
KC
Schneider
Karol H
KH
Katz
Robert W
RW
Makuch
Allan L
AL
Reiss
Laura R
LR
Ment
D002540:Cerebral Cortex / Q000002:abnormalities / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000517:prevention & control; D002552:Cerebral Ventricles; D002648:Child; D002675:Child, Preschool; D003237:Connecticut; D002658:Developmental Disabilities / Q000175:diagnosis* / Q000517:prevention & control / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000523:psychology; D019102:Infant, Very Low Birth Weight; D007805:Language Development Disorders / Q000175:diagnosis* / Q000517:prevention & control / Q000523:psychology; D007859:Learning Disabilities / Q000175:diagnosis* / Q000517:prevention & control / Q000523:psychology; D008279:Magnetic Resonance Imaging; D008297:Male; D011446:Prospective Studies; D013702:Temporal Lobe / Q000002:abnormalities* / Q000187:drug effects / Q000473:pathology; D014888:Wechsler Scales