[Cytoprotective effects of bilirubin].
Bilirubin, a major product of heme catabolism, belongs to compounds with pleiotropic biologic effects. For a long time bilirubin was considered as a metabolite dangerous for human health, neonatologists know well serious clinical complication of neonatal jaundice called bilirubin encephalopathy. Nevertheless, recent data has demonstrated that bilirubin exhibits potent antioxidant and even anti-inflammatory effects with substantial clinical impacts. The aim of the present study was to summarize present knowledge in this rapidly evolving field and suggest further possible clinical consequences.
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Ustav klinické biochemie a laboratorní diagnostiky a IV. interní klinika 1. LF UK a VFN, Praha. vitek@cesnet.cz
D001663:Bilirubin / Q000737:chemistry / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000503:physiopathology; D019610:Cytoprotection; D006801:Humans; D018384:Oxidative Stress
D001663:Bilirubin