The absorption and metabolism of modified amino acids in processed foods.
The chemical reactions involved in the modifications of amino acids in processed food proteins are described. They concern the Maillard reaction, reaction with polyphenols and tannins, formation of lysinoalanine during alkaline and heat treatments, formation of isopeptides, oxidation reaction of the sulfur amino acids, and isomerization of the L-amino acids into their D-form. Information on the digestion, absorption, and urinary excretion of the reaction products obtained by using conventional nutritional tests is given. The studies that have been made on the metabolism of these molecules by using a radioisotopic approach to follow their kinetics in the organism after ingestion are also reviewed. This approach provides unique data on the quantitation of the metabolic pathways and on the kinetics of the metabolic processes involved.
Finot
Paul-André
PA
Nestlé Research Centre, Vers-chez-les-Blanc, 1000-Lausanne 26, Switzerland. p.a.finot@bluewin.ch
D000042:Absorption; D000596:Amino Acids / Q000032:analysis*; D000818:Animals; D005419:Flavonoids / Q000032:analysis / Q000737:chemistry; D005504:Food Analysis / Q000379:methods*; D005511:Food Handling; D005632:Fructose / Q000737:chemistry / Q000652:urine; D005947:Glucose / Q000737:chemistry; D006358:Hot Temperature; D006801:Humans; D007700:Kinetics; D008239:Lysine / Q000031:analogs & derivatives / Q000032:analysis / Q000737:chemistry / Q000652:urine; D008241:Lysinoalanine / Q000032:analysis; D009584:Nitrogen / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry; D010455:Peptides / Q000032:analysis / Q000737:chemistry; D010636:Phenols / Q000032:analysis / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D059808:Polyphenols; D051381:Rats; D013552:Swine; D013634:Tannins / Q000032:analysis
D000596:Amino Acids; D005419:Flavonoids; D010455:Peptides; D010636:Phenols; D011108:Polymers; D059808:Polyphenols; D013634:Tannins; C011908:melanoidin polymers; D008241:Lysinoalanine; D005632:Fructose; C048496:N(6)-carboxymethyllysine; D005947:Glucose; D008239:Lysine; D009584:Nitrogen; D010100:Oxygen