Cerebral composite atypical teratoid/rhabdoid tumor and yolk sac tumor in the frontal lobe of an infant. Case report.
A 1-year-old male infant presented with a rare cerebral composite tumor consisting of atypical teratoid/rhabdoid tumor (AT/RT) with epithelial and mesenchymal components and yolk sac tumor (YST) with Schiller-Duval bodies. He was admitted to our medical center with a 2-month history of right hemiparesis. Computed tomography and magnetic resonance imaging revealed a large, intra-axial solid tumor with a cyst in the left frontal lobe. Total resection of the tumor was performed. Histological examination showed two different main growth patterns: solid sheets of undifferentiated polygonal cells and a few rhabdoid cells with rosette structures and rhabdomyoblastic cells; and reticular or papillary structures with occasional Schiller-Duval bodies in a myxoid matrix. The immunohistochemical and electron microscopy findings indicated composite AT/RT and YST. Initial total resection of the tumor was subsequently followed by local recurrence, hydrocephalus, and spinal metastasis. Despite adjuvant chemotherapy, the patient died 9 months after admission. AT/RT is a recently established entity of the central nervous system. The present case of composite AT/RT and YST in the frontal lobe indicates the poor prognosis of such tumors.
Department of Neurosurgery, National Nagasaki Medical Center, Omura, Japan. mhonda@net.nagasaki-u.ac.jp
Masaru
M
Honda
Hiroshi
H
Baba
Masahiro
M
Yonekura
Masachika
M
Iseki
D001932:Brain Neoplasms / Q000473:pathology* / Q000601:surgery; D018240:Endodermal Sinus Tumor / Q000150:complications / Q000473:pathology* / Q000601:surgery; D005625:Frontal Lobe / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D019635:Neurosurgical Procedures; D018335:Rhabdoid Tumor / Q000150:complications / Q000473:pathology* / Q000601:surgery; D013724:Teratoma / Q000150:complications / Q000473:pathology* / Q000601:surgery