HIV superinfection.
Worldwide, 16 cases of HIV-1 superinfection in humans have been reported since 2002. Superinfection is defined as the reinfection of an individual who already has an established infection with a heterologous HIV strain. Controversy exists surrounding superinfection, because it has implications concerning our understanding of worldwide HIV diversity, individual immunity and disease progression, and vaccine development. Here, we review the current understanding of HIV superinfection.
Smith
Davey M
DM
University of California, San Diego, 92093, USA. davey@ucsd.edu
Richman
Douglas D
DD
Little
Susan J
SJ
D017088:AIDS-Related Opportunistic Infections / Q000145:classification / Q000453:epidemiology*; D014943:Global Health; D006801:Humans; D015163:Superinfection