Effect of vaginal metronidazole + miconazole treatment during pregnancy for gestational age and birth weight in a population-based study.
The objective of the study was to check the effect of the combination of metronidazole and miconazole (M+M) for the prevention of sexually transmitted infections/disorders related preterm delivery/birth. Antiprotozoal vaginal metronidazole was not able to prevent preterm birth, while the antifungal topical miconazole use showed some reduction in preterm birth in our previous studies. The population-based large control (without any defects) data set of the Hungarian Case-Control Surveillance System of Congenital Abnormalities was used for the evaluation of the combination of M+M for birth outcomes. Of 38,151 controls, 846 (2.2%) had treatment with vaginal tablet of M+M for vaginal infections. The prevalence of preterm birth was 9.5% after this treatment compared with the 9.2% of preterm birth in the untreated group. Thus the combination of M+M was not able to reduce the preterm birth associated with vulvovaginal infections/disorders.
Foundation for the Community Control of Hereditary Diseases, Trkvsz lejt 32., Budapest, 1026, Hungary.
Zoltán
Z
Kazy
Erzsébet
E
Puhó
Andrew E
AE
Czeizel
D000282:Administration, Intravaginal; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage*; D001724:Birth Weight; D016022:Case-Control Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D006814:Hungary; D007231:Infant, Newborn; D007234:Infant, Premature; D008795:Metronidazole / Q000008:administration & dosage*; D008825:Miconazole / Q000008:administration & dosage*; D007752:Obstetric Labor, Premature / Q000382:microbiology / Q000517:prevention & control*; D011247:Pregnancy; D011446:Prospective Studies; D012189:Retrospective Studies; D012749:Sexually Transmitted Diseases / Q000188:drug therapy* / Q000382:microbiology; D014623:Vaginal Diseases / Q000188:drug therapy* / Q000382:microbiology
D000935:Antifungal Agents; D008795:Metronidazole; D008825:Miconazole