Magnetic resonance imaging in neonatal nonketotic hyperglycinemia.
This report presents two neonates with nonketotic hyperglycinemia in whom conventional magnetic resonance imaging revealed structural cerebral abnormalities, diffusion-weighted imaging indicated abnormalities of myelinated white matter, and magnetic resonance spectroscopy provided biochemical evidence of elevated cerebral glycine levels. The early use of combined magnetic resonance modalities in these severely affected infants helped in prognostication and clinical management.
Shah
Divyen K
DK
Departments of Neonatal Medicine and Medical Imaging, Royal Children's Hospital, Flemington Road, Parkville, 3052 Victoria, Australia.
Tingay
David G
DG
Fink
A Michelle
AM
Hunt
Rod W
RW
Dargaville
Peter A
PA
D001921:Brain / Q000378:metabolism / Q000473:pathology; D006801:Humans; D020158:Hyperglycinemia, Nonketotic / Q000097:blood / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male