[Efficacy of conventional mono mac therapy and mono mac chronotherapy of painless myocardial ischemia in patients with insulin-independent diabetes].
60 patients, suffering from coronary heart disease with painless myocardial ischemia (PMI) and insulin-independent diabetes (IID), were randomized into two groups. The first group included 18 patients, who received conventional mono mac therapy in a dose of 20 mg twice a day, the second--42 patients, whose treatment consisted in mono mac chronotherapy, i.e. they were administered a single dose of 10 to 20 mg of the drug 30 minutes before a PMI episode, revealed by means of Holter ECG-monitoring, before the beginning of the treatment. All the patients underwent examination, which consisted in Holter ECG-monitoring and Echo-CG, before and after a 15-day mono mac therapy course and adequate IID treatment. The study demonstrated that the total length and number of PMI episodes within a 24-hour interval, as well as the average episode length, were significantly less in the second group, compared with conventionally treated patients. The chronotherapy allowed a 2-fold reduction in mono mac doses.
R M
RM
Zaslavskaia
B A
BA
Aĭtmagambetova
D000368:Aged; D019454:Chronotherapy / Q000379:methods; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D015716:Electrocardiography, Ambulatory / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications / Q000188:drug therapy*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage*
D014665:Vasodilator Agents; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate