Four new HLA class I alleles in Cauacasoids.
Four new HLA classical class I alleles in the three loci are described in Caucasian individuals. A*3012 was first suspected by an abnormal serologic pattern that would be explained by the single amino acid substitution at the A30-specific Ser17. B*270505 differs from B*270502 in a silent substitution at an up to now constant position in the B locus. B*3541 encodes for a new Cys at position 118 that has not been encountered in neither human nor primate alleles. Cw*0716 seems to be originated by a large-scale interallelic recombination event between Cw*0701/*0706/*0718 and Cw*020202, giving rise to a new antigen-binding cleft conformation.
Laboratory of Histocompatibility, Regional Transfusion Center, Madrid, Spain.
M
M
Alonso-Nieto
F
F
García-Sánchez
R
R
Lillo
A
A
Balas
L
L
Blanco
M J
MJ
Aviles-Egea
L
L
Zarapuz
J L
JL
Vicario
D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D003545:Cysteine / Q000235:genetics; D005805:Genes, MHC Class I / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D015236:HLA-C Antigens / Q000235:genetics*; D006579:Heterozygote; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D009154:Mutation; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic; D044465:White People
D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D015395:Histocompatibility Antigens Class I; D003545:Cysteine