Pineapple juice labeled with gadolinium: a convenient oral contrast for magnetic resonance cholangiopancreatography.
The aim of our study was to prepare in vitro a pineapple juice (PJ) solution labeled with a minimal gadolinium concentration working as a negative contrast agent in heavily T2-weighted imaging and to assess that solution in vivo as a negative oral contrast agent for magnetic resonance cholangiopancreatography (MRCP). Three PJs were compared in vitro according to their T2. Increasing concentrations of gadolinium (Gd)-DOTA in PJ were assessed in vitro for T2 reduction. Single-shot turbo spin echo T2-weighted MR cholangiopancreatograms were obtained for 35 patients with suspected biliopancreatic duct disease, before and after ingestion of the PJ/Gd-DOTA solution. Signal intensity (SI) measurements of gastroduodenal lumens, pancreatobiliary ducts, and image quality scores were obtained systematically before and after contrast ingestion. The in vitro selected Gd-DOTA concentration in the PJ was 2.76 mmol/l. Ingestion of 180 ml of PJ labeled with 1 ml of Gd-DOTA eliminated efficiently the gastroduodenal SI in MRCP, improving significantly the rates of complete visualization of the pancreatobiliary ducts (P<0.01) and the MRCP image quality scores (P<0.05). All patients easily ingested the contrast solution and found the solution palatable. PJ labeled with gadolinium constituted an efficient and convenient negative oral contrast agent for MRCP.
Department of Radiology, Division of Magnetic Resonance, Hôpital Erasme, Université Libre de Bruxelles, 808 route de Lennik, 1070, Brussels, Belgium. emcoppen@ulb.ac.be
Emmanuel
E
Coppens
Thierry
T
Metens
Catherine
C
Winant
Celso
C
Matos
D000284:Administration, Oral; D031230:Ananas; D001628:Beverages; D049448:Cholangiopancreatography, Magnetic Resonance / Q000379:methods*; D003135:Common Bile Duct / Q000000981:diagnostic imaging / Q000378:metabolism; D003287:Contrast Media / Q000008:administration & dosage* / Q000378:metabolism; D004386:Duodenum / Q000000981:diagnostic imaging / Q000378:metabolism; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D006500:Hepatic Duct, Common / Q000000981:diagnostic imaging / Q000378:metabolism; D006571:Heterocyclic Compounds / Q000008:administration & dosage* / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009126:Muscle Relaxation / Q000187:drug effects; D009942:Organometallic Compounds / Q000008:administration & dosage* / Q000378:metabolism; D010183:Pancreatic Ducts / Q000000981:diagnostic imaging / Q000378:metabolism; D028321:Plant Preparations; D011856:Radiographic Image Enhancement; D015203:Reproducibility of Results; D013270:Stomach / Q000000981:diagnostic imaging
D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D028321:Plant Preparations; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate