Effects of long-term growth hormone-releasing factor treatment on growth, feed conversion efficiency and dry matter intake in growing female buffaloes (Bubalus bubalis).
Effects of long-term growth hormone-releasing factor (GRF) on growth performance, feed conversion efficiency (FCE) and dry matter intake (DMI) were studied in growing buffaloes. Twelve female Murrah buffaloes of 6-8 months of age were divided into two groups of six each on the basis of their body weights so that the average body weights of the groups did not differ (p > 0.05). Animals of each group were administered intravenously with either sterile distilled water (control group) or equal volume of GRF solution containing 10 mug GRF (1-44)-NH2/100 kg body weight (treatment group) at fortnight interval from week 6 (5-week pre-treatment period) for 36 weeks (weeks 6-42 treatment period). Thereafter a 10-week post-treatment period was added. All the animals were weighed consecutively 2 days in a week and the average body weight of the two observations in the week was thus considered for further calculation. Dry matter intake was recorded daily. Average daily gain, FCE and DMI/100 kg body weight were also calculated. Plasma progesterone was estimated in the samples collected twice a week at 3-4-day intervals to assess whether either group had begun ovarian cycles. It was found that ADG and FCE were higher (p < 0.01) in GRF-treated animals during treatment and even 10-week post-treatment period. Interestingly, total DMI was not different (p > 0.05) between the groups during treatment period but found to be lower in GRF treated animals during post-treatment period. The DMI/100 kg body weight was lower (p < 0.01) in GRF-treated animals during treatment and even after cessation of treatment for 10 weeks. The GRF administration for long-term increased (p < 0.05) plasma progesterone. Plasma progesterone concentrations suggest that no animal from either group reached puberty till the end of the experiment. In conclusion, repeated GRF administration for longer term decreased (p < 0.01) DMI/100 kg body weight and increased (p < 0.01) FCE and enabled the animals to grow faster.
Dairy Cattle Physiology Division, National Dairy Research Institute, Karnal, Haryana, India. mohan_mondal@rediffmail.com
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Mondal
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Prakash
D000818:Animals; D002020:Buffaloes / Q000254:growth & development* / Q000502:physiology; D004435:Eating / Q000187:drug effects*; D002149:Energy Intake / Q000187:drug effects*; D005260:Female; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology*; D011374:Progesterone / Q000097:blood; D011897:Random Allocation; D013997:Time Factors; D015430:Weight Gain
D011374:Progesterone; D013007:Growth Hormone-Releasing Hormone