[Is leptin the missing link between osteoarthritis and obesity?].
The contribution of leptin, as a possible link between osteoarthritis (OA) and obesity, was studied in cartilage and synovial fluid samples obtained from osteoarthritic patients. Its effect on cartilage was evaluated in rats after intraarticular injections of leptin. Leptin levels were measured in the synovial fluid samples by enzyme linked immunosorbent assay; leptin concentrations were correlated with the body mass index. Leptin was strongly expressed in osteophytes and OA cartilage, while, in normal cartilage, few chondrocytes produced leptin. The level of leptin expression was related to the grade of cartilage destruction and was in good relation with those of growth factors as IGF1 and TGFb. Studies in rats showed that intraarticular leptin injection stimulated anabolic functions of chondrocytes and induced the synthesis of leptin, IGF1 and TGFB in cartilage at both the chondrocytes and induced the synthesis of leptin, IGF1 and TGFB in cartilage at both the mRNA and protein levels. In conclusion, leptin may be a link between osteoarthritis and obesity, and may play a key role in cartilage metabolism. Leptin may contribute to the pathophysiology of OA.
Laboratoire de Pharmacologie, UMR 7561 CNRS-UHP, Faculté de Médecine de Nancy (Université Henri Poincaré Nancy 1), Vandoeuvre-lès-Nacy Cedex.
B
B
Terlain
H
H
Dumond
N
N
Presle
D
D
Mainard
A
A
Bianchi
D
D
Loeuille
P
P
Netter
P
P
Pottie
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002356:Cartilage / Q000378:metabolism; D007155:Immunologic Factors / Q000494:pharmacology; D020738:Leptin / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D009765:Obesity / Q000150:complications* / Q000378:metabolism*; D010003:Osteoarthritis / Q000150:complications* / Q000378:metabolism*; D010006:Osteoblasts / Q000187:drug effects; D051381:Rats; D013582:Synovial Fluid / Q000378:metabolism
D007155:Immunologic Factors; D020738:Leptin