[Chromosomal rearrangements breakpoints clusterization: is the clonal selection involved].
Certain types of cancer are often correlate with certain chromosomal rearrangements. The chimaeric genes are formed as a result of this rearrangements, and the chimaeric proteins are the products of their expression. The breakpoints of such translocation are often clustered in the genome. Moreover, such breakpoint clusters often contain specific genomic elements like topoisomerase II consensus sites, nuclear matrix attachment regions and DNA sequences, which can make up secondary non-canonical structure. In this review we discuss whether breakpoints may be induced by chromatin structure. Furthermore, we bring up not touched upon literature question about the relation between the breakpoint clusters and the domain organization of corresponding proteins. We also consider possible mechanisms of chromosomal rearrangements.
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Umanskaia
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Bystritskiĭ
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Razin
D000818:Animals; D019457:Chromosome Breakage / Q000235:genetics*; D004250:DNA Topoisomerases, Type II / Q000235:genetics / Q000378:metabolism; D015321:Gene Rearrangement; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000378:metabolism; D012641:Selection, Genetic; D014178:Translocation, Genetic
D015514:Oncogene Proteins, Fusion; D004250:DNA Topoisomerases, Type II