Prognostic value of KIT mutation in gastrointestinal stromal tumors.
OBJECTIVE
To examine the prevalence and prognostic significance of C-kit gene mutation and analysis the correlation of C-kit gene mutation and the clinicalpathologic parameters of GISTs.


METHODS
Eighty-two GISTs were studied for the mutation of C-kit gene by PCR-SSCP, DNA sequence. Statistical comparison were used to analysis the correlation of C-kit gene mutation and clinicalpathology, clinical behavior, recurrence.


RESULTS
(1) Mutation-positive and mutation-negative GISTs were 34 and 48,respectively; (2) Among these patients with C-kit mutation remained a significantly poor prognosis associated with 59% 3-year survival compared to those whose tumors did not; (3) Tumor size, PCNA index, mitotic cell number, presence of necrosis, microscopic invasion to adjacent tissues, recurrence and distant metastasis among mutation-positive and mutation-negative GISTs were significantly different.


CONCLUSIONS
C-kit mutation is a undoubtedly pivotal event in GIST and may be associated with poor prognosis. Evaluation of C-kit gene mutation may have both prognosis and therapeutic significances.
Department of Pathology, Changhai Hospital, Second Military Medical University, Changhai Road, Shanghai 200433, China.
Xiao-Hong
XH
Liu
Chen-Guang
CG
Bai
Qiang
Q
Xie
Fei
F
Feng
Zhi-Yun
ZY
Xu
Da-Lie
DL
Ma
D000328:Adult; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011379:Prognosis; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics*
D019009:Proto-Oncogene Proteins c-kit