Mouse models of osteoarthritis provide new research tools.
The options for pharmaceutical intervention of osteoarthritis are limited. There is therefore a crucial need for animal models of osteoarthritis that can be used as research tools for improving our understanding of the disease and for discovering and testing new treatments. Recently, a new mouse model of osteoarthritis was described in which the mice are unable to produce a bone morphogenetic protein (BMP) receptor specifically in joints. A comparison of this model to other models with different etiologies is presented. The findings suggest that all of the models could be linked molecularly.
Molecular Biology of Bones and Teeth Unit, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. Myoung@dir.nidcr.nih.gov
Marian F
MF
Young
D000818:Animals; D004195:Disease Models, Animal; D017353:Gene Deletion; D051379:Mice; D018345:Mice, Knockout; D010003:Osteoarthritis / Q000235:genetics / Q000628:therapy*