A topical cream containing a zinc gel (allergy guard) as a prophylactic against latex glove-related contact dermatitis.
BACKGROUND
Many health care workers are sensitized to the proteins in natural rubber latex and get contact dermatitis as a result of wearing latex gloves.


OBJECTIVE
The aim of the study was to evaluate a topical formulation containing a zinc gel (Allergy Guard) as a prophylactic against latex glove-related contact dermatitis.


METHODS
The study was carried out with volunteers who exhibited mild to moderate contact dermatitis (type IV) after wearing latex gloves as per the protocol.


RESULTS
Allergy Guard significantly reduced skin irritation in volunteers who exhibited type IV hypersensitivity when exposed to latex gloves. Allergy Guard also exhibited a barrier effect as shown by the permeation of chlorophyllin dye into the skin of volunteers. Allergy Guard prevented dermal irritation induced by sodium lauryl sulfate.


CONCLUSIONS
Topical formulations containing a zinc gel may be used to delay or prevent latex sensitivity, especially among health care professionals.
College of Physicians and Surgeons of Columbia University, New York, NY.
Shanta
S
Modak
Trupti A
TA
Gaonkar
Milind
M
Shintre
Lester
L
Sampath
Lauser
L
Caraos
Ingrid
I
Geraldo
D000287:Administration, Topical; D009783:Dermatitis, Occupational / Q000473:pathology / Q000517:prevention & control*; D003879:Dermatologic Agents / Q000008:administration & dosage*; D005782:Gels; D006229:Hand Dermatoses / Q000473:pathology / Q000517:prevention & control*; D006801:Humans; D020315:Latex Hypersensitivity / Q000473:pathology / Q000517:prevention & control*; D016896:Treatment Outcome; D015032:Zinc / Q000008:administration & dosage*
D003879:Dermatologic Agents; D005782:Gels; D015032:Zinc