Induction of telithromycin resistance by erythromycin in isolates of macrolide-resistant Staphylococcus spp.
Staphylococcal isolates were examined for possible macrolide-inducible resistance to telithromycin. All macrolide-resistant isolates demonstrated telithromycin D-shaped zones. This result did not discriminate between resistance due to an efflux mechanism (msrA) or a ribosomal target modification (ermA or ermC). Inducible telithromycin resistance in staphylococci does not appear to be analogous to inducible clindamycin resistance.
Davis
Kepler A
KA
Infectious Disease Service, Department of Medicine, Brooke Army Medical Center, Ft. Sam Houston, Texas 78234, USA. kepler.davis@amedd.army.mil
Crawford
Sharon A
SA
Fiebelkorn
Kristin R
KR
Jorgensen
James H
JH
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D003030:Coagulase / Q000378:metabolism; D024901:Drug Resistance, Multiple, Bacterial; D004917:Erythromycin / Q000494:pharmacology; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D048628:Ketolides / Q000494:pharmacology*; D018942:Macrolides / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013210:Staphylococcus / Q000145:classification / Q000187:drug effects* / Q000201:enzymology; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D003030:Coagulase; D048628:Ketolides; D018942:Macrolides; D004917:Erythromycin; C106791:telithromycin