A comparative study of calcium phosphate formation on bioceramics in vitro and in vivo.
Formation of calcium phosphate (Ca-P) on various bioceramic surfaces in simulated body fluid (SBF) and in rabbit muscle sites was investigated. The bioceramics were sintered porous solids, including bioglass, glass-ceramics, hydroxyapatite, alpha-tricalcium phosphate and beta-tricalcium phosphate. The ability of inducing Ca-P formation was compared among the bioceramics. The Ca-P crystal structures were identified using single-crystal diffraction patterns in transmission electron microscopy. The examination results show that ability of inducing Ca-P formation in SBF was similar among bioceramics, but considerably varied among bioceramics in vivo. Sintered beta-tricalcium phosphate exhibited a poor ability of inducing Ca-P formation both in vitro and in vivo. Octacalcium phosphate (OCP) formed on the surfaces of bioglass, A-W, hydroxyapatite and alpha-tricalcium phosphate in vitro and in vivo. Apatite formation in physiological environments cannot be confirmed as a common feature of bioceramics.
Department of Mechanical Engineering, Hong Kong University of Science and Technology, Hong Kong, China.
Renlong
R
Xin
Yang
Y
Leng
Jiyong
J
Chen
Qiyi
Q
Zhang
D000818:Animals; D001031:Apatites / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D001826:Body Fluids; D018786:Bone Substitutes; D002130:Calcium Phosphates / Q000737:chemistry*; D002516:Ceramics / Q000737:chemistry*; D020099:Coated Materials, Biocompatible; D017886:Durapatite / Q000737:chemistry; D066298:In Vitro Techniques; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D009132:Muscles / Q000378:metabolism; D011817:Rabbits; D013499:Surface Properties
D001031:Apatites; D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; C485828:alpha-tricalcium phosphate; C485817:beta-tricalcium phosphate; C022045:octacalcium phosphate; D017886:Durapatite; C020243:calcium phosphate; C018392:tricalcium phosphate