Habit learning and the genetics of the dopamine D3 receptor: evidence from patients with schizophrenia and healthy controls.
In this study, the authors investigated the relationship between the Ser9Gly (SG) polymorphism of the dopamine D3 receptor (DRD3) and striatal habit learning in healthy controls and patients with schizophrenia. Participants were given the weather prediction task, during which probabilistic cue-response associations were learned for tarot cards and weather outcomes (rain or sunshine). In both healthy controls and patients with schizophrenia, participants with Ser9Ser (SS) genotype did not learn during the early phase of the task (1-50 trials), whereas participants with SG genotype did so. During the late phase of the task (51-100 trials), both participants with SS and SG genotype exhibited significant learning. Learning rate was normal in patients with schizophrenia. These results suggest that the DRD3 variant containing glycine is associated with more efficient striatal habit learning in healthy controls and patients with schizophrenia.
Department of Psychiatry, University of Szeged, Szeged, Hungary. szkeri@phys.szote.u-szeged.hu
Szabolcs
S
Kéri
Anna
A
Juhász
Agnes
A
Rimanóczy
György
G
Szekeres
Oguz
O
Kelemen
Csongor
C
Cimmer
István
I
Szendi
György
G
Benedek
Zoltán
Z
Janka
D000328:Adult; D000704:Analysis of Variance; D003463:Cues; D004252:DNA Mutational Analysis / Q000379:methods; D005260:Female; D005998:Glycine / Q000235:genetics; D006184:Habits; D006801:Humans; D007858:Learning / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011110:Polymorphism, Genetic; D011237:Predictive Value of Tests; D011569:Psychiatric Status Rating Scales; D012333:RNA, Messenger / Q000096:biosynthesis; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050637:Receptors, Dopamine D3; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology; D012694:Serine / Q000235:genetics; D013647:Task Performance and Analysis
C493593:DRD3 protein, human; D012333:RNA, Messenger; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D012694:Serine; D005998:Glycine