Concise synthesis of dl-febrifugine.
Racemic compound (1) of the antimalarial agents febrifugine (d-1) was synthesized using an stereoselective Michael reaction of an omega-amidoenone (5) which was prepared by the Wittig reaction of piperidinediol (7).
Faculty of Pharmaceutical Sciences, Okayama University, Japan. take@pharm.okayama-u.ac.jp
Yasuo
Y
Takeuchi
Miyo
M
Oshige
Kumiko
K
Azuma
Hitoshi
H
Abe
Takashi
T
Harayama
D000962:Antimalarials / Q000138:chemical synthesis*; D015394:Molecular Structure; D010880:Piperidines; D011799:Quinazolines / Q000138:chemical synthesis*
D000962:Antimalarials; D010880:Piperidines; D011799:Quinazolines; C001207:febrifugine