Effect of poly(ethylene oxide) on the release behaviors of poly(epsilon-caprolactone) microcapsules containing erythromycin.
The biodegradable poly(epsilon-caprolactone) (PCL)/poly(ethylene oxide) (PEO) microcapsules and the analyzing of form and features for the manufacturing conditions were investigated in a prospective drug delivery systems (DDS) through drug release. The effects of emulsifier, emulsifier concentration, and stirring rate on the diameter and form of the microcapsules were examined using image analyzer (IA) and scanning electron microscope (SEM). The role of interfacial adhesion between PCL/PEO and drug was determined by contact angle measurements, and the drug release rate of the microcapsules was characterized by UV-vis spectroscopy. As a result, the microcapsules were made in spherical forms with a mean particle size of 170 nm approximately 68 microm. And the work of adhesion between water and PCL/PEO was increased with increasing the PEO content, which is due to higher hydrophilicity of PEO. The drug release rate of the microcapsules was significantly increased as the PEO content increased, which could be attributed to the increasing of the hydrophilic groups or the degree of adhesion at the interfaces.
Advanced Materials Division, Korea Research Institute of Chemical Technology, Daejeon 305-600, Republic of Korea. psjin@krict.re.kr
Soo-Jin
SJ
Park
Ki-Seok
KS
Kim
Seung-Hak
SH
Kim
D000268:Adhesiveness; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry; D002214:Capsules; D004917:Erythromycin / Q000008:administration & dosage* / Q000737:chemistry; D007091:Image Processing, Computer-Assisted; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012997:Solvents; D013499:Surface Properties
D000900:Anti-Bacterial Agents; D002214:Capsules; D011091:Polyesters; D012997:Solvents; C016240:polycaprolactone; D011092:Polyethylene Glycols; D004917:Erythromycin