Blood typing in Saimiri sciureus monkeys: influence of anti-red blood cell alloantibodies on Plasmodium falciparum parasitaemia in vivo.
The Saimiri sciureus monkey is a well-established host for experimental studies with human malaria parasites. During the course of iterative inoculations with Plasmodium falciparum parasitised red blood cells (RBC), anti-RBC alloantibodies were detected in the sera of two of eight Saimiri monkeys. These anti-RBC antibodies were further used to investigate RBC phenotypes in 35 colony-reared Saimiri monkeys by flow cytometry. Three RBC phenotypes (named I-III) were observed. Their distribution was I (86%), II (11%) and III (3%). Using the Palo Alto FUP-2 strain, a variant P. falciparum line insensitive to hyperimmune serum and the passive transfer of anti-RBC alloantibodies, a dramatic drop in parasite growth was documented in an incompatible monkey.
Michel
Jean-Claude
JC
Laboratoire d'Immunologie Parasitaire et Unité de Primatologie, Institut Pasteur de la Guyane française, Cayenne, France. jcmichel@pasteur.fr
Behr
Charlotte
C
Morales-Betoulle
Maria Eugenia
ME
Jouin
Hélène
H
Mercereau-Puijalon
Odile
O
Contamin
Hugues
H
D000818:Animals; D001788:Blood Grouping and Crossmatching / Q000662:veterinary; D004912:Erythrocytes / Q000276:immunology*; D007518:Isoantibodies / Q000502:physiology*; D008297:Male; D018512:Parasitemia / Q000276:immunology / Q000662:veterinary; D010641:Phenotype; D010963:Plasmodium falciparum / Q000276:immunology*; D012453:Saimiri / Q000097:blood* / Q000276:immunology*
D007518:Isoantibodies