The toxicological study of CCNU controlled release film in vivo.
We planted the Lomustine (CCNU) controlled release films into normal mice, and after a period of time observed the effects of the films on the blood cells and the brain nerve cells of the mice. Compared with the traditional administration (PO), the results indicated that the planted CCNU controlled release film had less effects on the blood cells, and caused less harm to the brain nerve cells. So the conclusion was that the planted CCNU controlled release film had no significant acute arrest of bone marrow and neural toxicity.
National Pharmaceutical Research Center, Lunan Pharmaceutical Corporation, Linyi city, Shandong, China. yong.sun@vip.sina.com
Yong
Y
Sun
Lisa
L
Xu
Qiqing
Q
Zhang
Haiying
H
Zhou
Fujun
F
Wang
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000633:toxicity*; D001853:Bone Marrow / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D003692:Delayed-Action Preparations / Q000633:toxicity; D005260:Female; D008130:Lomustine / Q000633:toxicity*; D008297:Male; D051379:Mice
D018906:Antineoplastic Agents, Alkylating; D003692:Delayed-Action Preparations; D008130:Lomustine