Critical care clotting catastrophies.
Coagulation problems are very common in intensive care patients. It is important to recognize potential problems, perform a rapid assessment, and start therapy. The author reviews general clinical and laboratory approaches to diagnosis and treatment of the bleeding patient and to correction of coagulopathies. This review outlines a set of often catastrophic coagulation problems, which may present both thrombotic and bleeding challenges. These include heparin induced thrombocytopenia, thrombotic thrombocytopenic purpura, and disseminated intravascular coagulation.
DeLoughery
Thomas G
TG
Oregon Health & Science University, Hematology L586, 3181 SW Sam Jackson Park Road, Portland, OR 97201-3098, USA. delought@ohsu.edu
D000818:Animals; D000925:Anticoagulants / Q000009:adverse effects*; D001778:Blood Coagulation Disorders / Q000145:classification / Q000209:etiology* / Q000628:therapy; D001780:Blood Coagulation Tests; D003422:Critical Care; D004347:Drug Interactions; D005260:Female; D006487:Hemostasis / Q000187:drug effects* / Q000502:physiology; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D007362:Intensive Care Units; D010976:Platelet Count; D011247:Pregnancy; D013921:Thrombocytopenia / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis; D014813:Vitamin K Deficiency / Q000097:blood*
D000925:Anticoagulants; D006493:Heparin