Losses of 1p and chromosome 14 in renal oncocytomas.
We performed cytogenetic analyses of 8 renal oncocytomas to identify chromosomal regions involved in the tumorigenesis of oncocytomas. All cases showed chromosomal findings corresponding to established cytogenetic subsets of renal oncocytomas: 3 cases with normal karyotypes, 1 case with rearrangement of 11q, and 4 cases with losses of chromosome 14. In the latter cytogenetic subgroup, monosomy 14 was additionally accompanied by either monosomy 1 in 2 cases or loss of 1p in a third case, providing insights in the cytogenetic evolution of this subgroup.
Füzesi
László
L
Department of Pathology, Georg-August-Universität Gottingen, Robert-Koch-StraBe 40, Postfach 3032, Göttingen D-37075, Germany. fuezesi@med.uni-goettingen.de
Frank
Derk
D
Nguyen
Christian
C
Ringert
Rolf-Hermann
RH
Bartels
Henning
H
Gunawan
Bastian
B
D018249:Adenoma, Oxyphilic / Q000235:genetics* / Q000473:pathology; D000328:Adult; D000368:Aged; D000782:Aneuploidy; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged