Membrane for immunoisolation--properties before, and post implantation: preliminary report.
The membranes preventing tissue overgrowth as well as toxic influence on cells encapsulated within can be obtained modifying the polypropylene membranes by silanization. The influence of the silanization with different siloxanes on membrane transport properties was assessed before and post implantation. No change in cut-off values was observed. All of the modified membranes delayed tissue overgrowth of implant in mouse. Spectroscopic evaluation of the membrane material after 4, 7 days, 2 and 4 months of implantation revealed membrane material stability. We concluded that evaluated membranes with cells encapsulated within may be applied as the systems for delivery of biologically active substances.
Institute of Biocybernetics and Biomedical Engineering, PAS, Warsaw, Poland. ludomira@ibib.waw.pl
L H
LH
Granicka
A
A
Weryński
E
E
Jankowska
J
J
Kawiak
D000818:Animals; D001672:Biocompatible Materials; D008567:Membranes, Artificial; D051379:Mice; D011126:Polypropylenes; D019736:Prostheses and Implants
D001672:Biocompatible Materials; D008567:Membranes, Artificial; D011126:Polypropylenes