Successful treatment of extensive basidiobolomycosis with oral itraconazole in a child.
BACKGROUND
Basidiobolomycosis is a rare chronic subcutaneous infection caused by Basidiobolus ranarum, which is usually treated with potassium iodide. Extensive deforming lesions in children can occur owing to lack of early diagnosis and/or inappropriate treatment.


METHODS
An 8-year-old girl child presented to us with extensive deforming plaque-like lesions over the left thigh and leg with multiple ulcerations of 1 year's duration. Histopathology was suggestive of subcutaneous zygomycosis with Splendore Hoeppli phenomenon. Microscopic examination of the tissue showed branching, sparsely septate fungal hyphae on a 10%KOH mount, and culture yielded Basidiobolus ranarum. The patient was initially treated with potassium iodide for 6 weeks to which only a poor response was observed. Itraconazole therapy resulted in rapid regression of the lesions and complete resolution after 15 weeks of therapy. She continues to be disease-free at 1 year of follow up.


CONCLUSIONS
This case report highlights that in an older child even longstanding extensive basidiobolomycosis can be safely treated with itraconazole. Surgery is not usually necessary in these patients.
Mathew
Renu
R
Pondicherry Institute of Medical Sciences, Kalapet, Pondicherry, India.
Kumaravel
S
S
Kuruvilla
Sheela
S
Varghese
Renu G'boy
RG
Shashikala
Srinivasan
S
S
Mani
M Z
MZ
D000284:Administration, Oral; D000935:Antifungal Agents / Q000008:administration & dosage*; D002648:Child; D020091:Entomophthorales / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage*; D016896:Treatment Outcome; D020096:Zygomycosis / Q000175:diagnosis / Q000188:drug therapy*
D000935:Antifungal Agents; D017964:Itraconazole