[Advances of study on activation of nuclear factor kappaB in hematological malignancies and its mechanism--review].
The nuclear factor kappa B(NF-kappaB) plays a crucial role in inflammatory, immune response, embryo development, cell proliferation and apoptosis, cell cycle control as well as tumorgenesis. In recent years, a variety of investigations have demonstrated that NF-kappaB was closely associated with the pathogenesis of hematological malignancies such as leukemia, lymphoma and multiple myeloma. Nowadays, increasingly attention has been paid to the studies on the activation and its mechanism of NF-kappaB in the hematogenic malignancies. So that, in this article, progress on these aspects is reviewed.
Wang
Guang-Ping
GP
Departmant of Hematology, Xiangya Hospilal, Central South University, Changsha 410008, China. guang-pingw@hotmail.com
Qi
Zhen-Hua
ZH
Chen
Fang-Ping
FP
D019337:Hematologic Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism*
D016328:NF-kappa B