Coagulopathy after successful cardiopulmonary resuscitation following cardiac arrest: implication of the protein C anticoagulant pathway.
OBJECTIVE
We investigated coagulation abnormalities in out-of-hospital cardiac arrest (OHCA) patients, with special attention to the protein C anticoagulant pathway.


BACKGROUND
Successfully resuscitated cardiac arrest is followed by a systemic inflammatory response and by activation of coagulation, both of which may contribute to organ failure and neurological dysfunction.


METHODS
Coagulation parameters were measured in all patients admitted after successfully resuscitated OHCA.


RESULTS
At admission, 67 patients had a systemic inflammatory response with increased interleukin-6 and coagulation activity (thrombin-antithrombin complex), reduced anticoagulation (antithrombin, protein C, and protein S), activated fibrinolysis (plasmin-antiplasmin complex), and, in some cases, inhibited fibrinolysis (increased plasminogen activator inhibitor-1 with a peak on day 1). These abnormalities were more severe in patients who died within two days (50 of 67, 75%) and were most severe in patients dying from early refractory shock. Protein C and S levels were low compared to healthy volunteers and discriminated OHCA survivors from nonsurvivors. Furthermore, a subgroup of patients had a transient increase in plasma-activated protein C at admission followed by undetectable levels. This, along with an increase in soluble thrombomodulin over time, suggests secondary endothelial injury and dysfunction of the protein C anticoagulant pathway similar to that observed in severe sepsis.


CONCLUSIONS
Major coagulation abnormalities were found after successful resuscitation of cardiac arrest. These abnormalities are consistent with secondary down-regulation of the thrombomodulin-endothelial protein C receptor pathway.
Adrie
Christophe
C
Intensive Care Unit, Delafontaine Hospital, Saint Denis, France. christophe.adrie@wanadoo.fr
Monchi
Mehran
M
Laurent
Ivan
I
Um
Suzan
S
Yan
S Betty
SB
Thuong
Marie
M
Cariou
Alain
A
Charpentier
Julien
J
Dhainaut
Jean François
JF
D000368:Aged; D000991:Antithrombins / Q000378:metabolism; D001779:Blood Coagulation Factors / Q000378:metabolism; D016887:Cardiopulmonary Resuscitation; D016022:Case-Control Studies; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D006323:Heart Arrest / Q000097:blood* / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D011486:Protein C / Q000378:metabolism*; D017293:Protein S / Q000378:metabolism; D013918:Thrombin Time; D018180:Thrombomodulin / Q000097:blood
D000991:Antithrombins; D001779:Blood Coagulation Factors; D005338:Fibrin Fibrinogen Degradation Products; D011486:Protein C; D017293:Protein S; D018180:Thrombomodulin; C036309:fibrin fragment D