Dietary supplementation with n-3 polyunsaturated fatty acids attenuates the depression of food-motivated behavior during zymosan-induced peritonitis.
Peripheral inflammation is accompanied by neurobehavioral alterations such as depression of feeding, exploratory and sexual behaviors. Our previous investigation reported that dietary enrichment with n-3 polyunsaturated fatty acids (PUFA) attenuated the depression of food-motivated behavior and social exploration, but not endocrinological and metabolic disturbances in the mice with systemic inflammation induced by lipopolysaccharide (LPS). We here demonstrate that dietary n-3 PUFA also attenuate the reduction of food-motivated behavior during zymosan-induced peritonitis in mice without influencing plasma leakage into peritoneum and writhing response. Our results suggest that the common mechanism is involved in the attenuation of behavioral depression during systemic and local inflammation by dietary n-3 PUFA.
Division of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan.
Mizuki
M
Takenaka
Satoko
S
Kanada
Tomohito
T
Hamazaki
Shiro
S
Watanabe
D000818:Animals; D019587:Dietary Supplements; D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage* / Q000494:pharmacology; D005247:Feeding Behavior / Q000187:drug effects*; D051379:Mice; D009042:Motivation; D010538:Peritonitis / Q000139:chemically induced / Q000503:physiopathology*; D014280:Triglycerides / Q000008:administration & dosage* / Q000494:pharmacology; D015054:Zymosan / Q000633:toxicity*
D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated; D014280:Triglycerides; C077446:Pikasol; D015054:Zymosan