Capsazepine, a vanilloid receptor antagonist, inhibits allergen-induced tracheal contraction.
To investigate the possible role of the vanilloid receptor-1 (TRPV1) in allergic airway responses, the effect of the specific TRPV1 receptor antagonist capsazepine was examined. Capsazepine significantly decreased the ovalbumin-induced contraction of isolated tracheal rings from ovalbumin-sensitized guinea pigs. This is the first report directly showing the involvement of the TRPV1 in experimental allergic airway responses.
Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO BOX 80082, 3508 TB Utrecht, The Netherlands.
Edwin
E
van den Worm
Annick
A
de Vries
Frans P
FP
Nijkamp
Ferdi
F
Engels
D000485:Allergens / Q000494:pharmacology*; D000818:Animals; D002211:Capsaicin / Q000031:analogs & derivatives* / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D010047:Ovalbumin / Q000494:pharmacology; D011955:Receptors, Drug / Q000037:antagonists & inhibitors* / Q000502:physiology; D014132:Trachea / Q000187:drug effects* / Q000502:physiology
D000485:Allergens; D011955:Receptors, Drug; D010047:Ovalbumin; C071423:capsazepine; D002211:Capsaicin