Cytoprotectivity of Prunella vulgaris on doxorubicin-treated rat cardiomyocytes.
The cardioprotective effect of Prunella vulgaris ethylacetate fraction (PVEF) and its constituent rosmarinic acid (RA) was evaluated on isolated rat cardiomyocytes subjected to doxorubicin-induced oxidative stress. The cytoprotectivities of PVEF and RA were concentration-dependent in the range of 0.005 to 0.05 mg/ml and the effect of PVEF correlated with the RA content. Dexrazoxan (DE), used as positive control, was less effective than PVEF or RA.
Psotová
J
J
Institute of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacký University, Hnĕvotínská 3, 775 15 Olomouc, Czech Republic. psotova@tunw.upol.cz
Chlopcíková
S
S
Miketová
P
P
Simánek
V
V
D000818:Animals; D000903:Antibiotics, Antineoplastic; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002934:Cinnamates / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D053630:Depsides; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin; D005260:Female; D008297:Male; D032383:Myocytes, Cardiac / Q000187:drug effects*; D018384:Oxidative Stress; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D031347:Prunella; D051381:Rats; D017207:Rats, Sprague-Dawley; D000097123:Rosmarinic Acid
D000903:Antibiotics, Antineoplastic; D002316:Cardiotonic Agents; D002934:Cinnamates; D053630:Depsides; D004317:Doxorubicin; D010936:Plant Extracts; D000097123:Rosmarinic Acid