Stromal cell-derived factor-1 (SDF-1) alleles and susceptibility to breast carcinoma.
Stromal cell-Derived Factor-1 (SDF-1, CXCL12) is one the ELR- CXC angiogenic chemokines. It contributes to hematopoiesis and lymphocyte trafficking. SDF-1 and its exclusive receptor, CXCR4, are reported to play important roles in tumor growth, angiogenesis and metastasis of different types of tumors such as breast, lung, prostate and pancreatic cancers. SDF-1 gene polymorphism, known as SDF1-3'A, has been investigated in HIV-1 infection and the incidence of breast cancer. This investigation was aimed to study the frequency of SDF1-3'A mutation in Iranian women with breast cancer. Results showed that the frequency of AA and AG genotypes was higher among patients, while the frequency of GG genotype was lower compared to the controls. Thus AA and AG genotypes of SDF-1 may be considered as factors increasing the susceptibility of Iranian women to breast cancer.
Department of Immunology, Shiraz University of Medical Sciences, P.O. Box 71345-319, Shiraz, Iran.
Mahboobeh
M
Razmkhah
Abdul-Rasoul
AR
Talei
Mehrnoosh
M
Doroudchi
Tahereh
T
Khalili-Azad
Abbas
A
Ghaderi
D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007492:Iran; D009367:Neoplasm Staging
C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D019743:Chemokines, CXC