Mutator effects in Escherichia coli caused by the expression of specific foreign genes.
Certain genes from Lactococcus lactis and Pseudomonas aeruginosa, including the nfxB gene, generate a mutator phenotype in Escherichia coli. The results of this study, together with those of a previous study, support conservation of regulatory sequences in E. coli and P. aeruginosa and suggest that some efflux pumps prevent mutagenicity by exporting mutagenic products of metabolism.
Gabrovsky
Vanessa
V
Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, 90095, USA.
Yamamoto
Mitsuko Lynn
ML
Miller
Jeffrey H
JH
D001483:Base Sequence; D003001:Cloning, Molecular; D017931:DNA Primers; D004269:DNA, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D016254:Mutagenesis, Insertional; D016133:Polymerase Chain Reaction; D011550:Pseudomonas aeruginosa / Q000235:genetics*; D015183:Restriction Mapping
D017931:DNA Primers; D004269:DNA, Bacterial