One pot synthesis of oxygenated tri-heterocycles as anti-microbial agents.
A one pot synthesis of an array of angularly linked tri-heterocycles with coumarin, benzofuran and furan rings is described. This high yielding synthesis is achieved by the reaction of various 4-bromomethylcoumarins with furyl o-hydroxyphenyl ketones involving benzylic nucleophilic displacement and intramolecular aldolization. All the compounds have been tested in vitro for their anti-microbial activity against Micrococcus aureus, Pseudomonas chinchori, Asperigillus fumigatus and Penicillium wortmanni at 100, 50, and 25 microg ml(-1) concentrations. Chloro groups in the benzofuran ring enhanced the activity.
Khan
Imthyaz A
IA
Department of Chemistry, Karnatak University, Dharwad 580003, Karnataka, India.
Kulkarni
Manohar V
MV
Sun
Chung-Ming
CM
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001572:Benzofurans / Q000138:chemical synthesis / Q000494:pharmacology; D003374:Coumarins / Q000138:chemical synthesis / Q000494:pharmacology; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests
D000890:Anti-Infective Agents; D001572:Benzofurans; D003374:Coumarins; D006575:Heterocyclic Compounds, 3-Ring