[FGF23 and bone metabolism].
Fibroblast growth factor (FGF) 23 was recently shown to alter serum phosphate level by modulating renal tubular phosphate reabsorption and production of active vitamin D independently of parathyroid hormone action. In addition, FGF23 was shown to be involved in the development of several diseases including autosomal dominant hypophosphatemic rickets/osteomalacia (ADHR), X-linked hypophosphatemic rickets/osteomalacia (XLH) and tumor-induced rickets/osteomalacia (TIO). It has also been suggested that FGF23 physiologically regulates serum phosphate level because FGF23 null mice show high serum concentration of phosphate.
Division of Nephrology and Endcrinology, Department of Internal Medicine, University of Tokyo.
Nobuaki
N
Ito
Seiji
S
Fukumoto
D000818:Animals; D001847:Bone Diseases / Q000209:etiology; D001842:Bone and Bones / Q000378:metabolism*; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000502:physiology*; D006801:Humans; D051379:Mice
C000717427:FGF23 protein, human; C000717428:Fgf23 protein, mouse; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23