Simvastatin given for 3 days can inhibit thrombin generation and activation of factor V and enhance factor Va inactivation in hypercholesterolemic patients.
Anetta
A
Undas
Magdalena
M
Celinska-Löwenhoff
Kathleen E
KE
Brummel-Ziedins
Jan
J
Brozek
Andrew
A
Szczeklik
Kenneth G
KG
Mann
D001777:Blood Coagulation / Q000187:drug effects*; D005165:Factor V / Q000378:metabolism; D015943:Factor Va / Q000378:metabolism; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D019821:Simvastatin / Q000008:administration & dosage*; D013917:Thrombin / Q000378:metabolism
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D015943:Factor Va; D005165:Factor V; D019821:Simvastatin; D013917:Thrombin