Liuweidihuang-tang improves spatial memory function and increases neurogenesis in the dentate gyrus in rats.
The aqueous extract of Liuweidihuang-tang given to rats at doses of 100 mg/kg/day for 10 days induced a reduction in the frequency of error and increased neurogenesis in the hippocampal dentate gyrus. Our data suggest that Liuweidihuang-tang improves spatial learning ability by increasing neurogenesis in the dentate gyrus.
Lee
Kwang-Sik
KS
Kohwang Medical Research Institute, College of Medicine, Kyung Hee University, Seoul, South Korea.
Lim
Baek-Vin
BV
Chang
Hyun-Kyung
HK
Yang
Hye-Young
HY
Bahn
Geon-Ho
GH
Paik
Eun-Kyung
EK
Park
Jae-Hyung
JH
Kim
Chang-Ju
CJ
D000818:Animals; D018891:Dentate Gyrus / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D007150:Immunohistochemistry; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D008517:Phytotherapy; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D013028:Space Perception / Q000187:drug effects* / Q000502:physiology
D004365:Drugs, Chinese Herbal