Co-administration of quercetin and catechin in rats alters their absorption but not their metabolism.
Quercetin and catechin are among the major flavonoids in plant foods and their intake has been associated to a risk reduction in several degenerative diseases. The aim of the present study was to bring data on the bioavailability of quercetin and catechin when administered simultaneously. The study was performed on rats adapted to diets containing (i) 0.25% quercetin, or (ii) 0.25% catechin, or (iii) 0.25% quercetin+0.25% catechin. Quercetin, catechin and their metabolites were determined in plasma, urine and liver by HPLC with UV or coulometric detection. When quercetin and catechin were fed in association, their respective plasma concentration significantly decreased (-35% and -28% respectively), whereas the urinary and hepatic concentrations were only affected for quercetin (-36%). These data may be explained by a competitive interaction between quercetin and catechin at the digestive level, leading to a reduction of the intestinal absorption of quercetin and a possible delaying of catechin absorption over time. The simultaneous administration of quercetin and catechin had no effect on the formation of their glucurono and sulfo conjugates, indicating the absence of competition between quercetin and catechin for the corresponding conjugative enzymes.
Laboratoire des Maladies Métaboliques et des Micronutriments, I.N.R.A, Centre de Recherche de Clermont-Ferrant/Theix, 63122 Saint Genès-Champanelle, France.
Mathieu
M
Silberberg
Christine
C
Morand
Claudine
C
Manach
Augustin
A
Scalbert
Christian
C
Remesy
D000821:Animal Feed; D000818:Animals; D001682:Biological Availability; D002392:Catechin / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D004347:Drug Interactions; D007408:Intestinal Absorption / Q000187:drug effects*; D008099:Liver / Q000378:metabolism*; D008297:Male; D011794:Quercetin / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology / Q000652:urine; D051381:Rats; D017208:Rats, Wistar
D002392:Catechin; D011794:Quercetin