Hypolipidemic effect of methanolic extract of Dolichos biflorus Linn. in high fat diet fed rats.
High fat diet fed rats showed significant increased levels of plasma and tissue total cholesterol, triglycerides, free fatty acids, phospholipids, plasma LDL cholesterol and decreased level of plasma HDL cholesterol. Methanolic extract of D. biflorus administration to high fat diet fed rats showed near to normal levels of the above lipids in plasma and tissues. Higher dose of the extract (400 mg/kg body weight) showed comparable results with standard drug atorvastatin. It is concluded that the methanolic extract of D. biflorus possesses hypolipidemic activity in high fat diet fed rats.
Department of Pharmacy, Annamalai University, Annamalai Nagar 608 002, India. subbumuthu76@yahoo.com
A Kottai
AK
Muthu
S
S
Sethupathy
R
R
Manavalan
P K
PK
Karar
D000818:Animals; D000069059:Atorvastatin; D002784:Cholesterol / Q000378:metabolism; D008076:Cholesterol, HDL / Q000378:metabolism; D008078:Cholesterol, LDL / Q000378:metabolism; D004036:Diet, Atherogenic; D004041:Dietary Fats / Q000378:metabolism*; D031294:Dolichos / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism; D006538:Heptanoic Acids / Q000494:pharmacology; D050356:Lipid Metabolism; D008055:Lipids / Q000737:chemistry; D008074:Lipoproteins / Q000737:chemistry; D008297:Male; D000432:Methanol / Q000737:chemistry / Q000494:pharmacology*; D010743:Phospholipids / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D011758:Pyrroles / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000737:chemistry / Q000378:metabolism
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004041:Dietary Fats; D005227:Fatty Acids; D006538:Heptanoic Acids; D008055:Lipids; D008074:Lipoproteins; D010743:Phospholipids; D010936:Plant Extracts; D011758:Pyrroles; D014280:Triglycerides; D002784:Cholesterol; D000069059:Atorvastatin; D000432:Methanol