Bioactivity guided isolation of antimicrobial compounds from Lythrum salicaria.
Lythrum salicaria extracts showed activity against the phytopathogenic fungus Cladosporium cucumerinum and activity against the bacteria Staphylococcus aureus, Proteus mirabilis and Microccocus luteus. Bioautography on thin-layer chromatograms was used to isolate the two antifungal triterpenoids oleanolic and ursolic acid. The hexahydroxydiphenoyl ester vescalagin was isolated as active principle of the antibacterial activity. Furthermore, the flavon-C-glucosides vitexin, isovitexin, orientin and isoorientin were isolated.
Becker
Hans
H
FR 8.7, Pharmakognosie und Analytische Phytochemie, Universität des Saarlandes, D-66041 Saarbrücken, Germany. prof_hans_becker@hotmail.com
Scher
Jochen M
JM
Speakman
John-Bryan
JB
Zapp
Josef
J
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects*; D002963:Cladosporium / Q000187:drug effects*; D006801:Humans; D031561:Lythrum; D008826:Microbial Sensitivity Tests; D016982:Micrococcus luteus / Q000187:drug effects; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011513:Proteus mirabilis / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D010936:Plant Extracts