Intracerebroventricular self-administration of commonly abused anabolic-androgenic steroids in male hamsters (Mesocricetus auratus): nandrolone, drostanolone, oxymetholone, and stanozolol.
Previous studies by the authors have shown voluntary intracerebroventricular (icv) testosterone self-administration in hamsters (Mesocricetus auratus). Here, the authors compared icv self-administration of 4 anabolic steroids (drostanolone, nandrolone, oxymetholone, and stanozolol) at 0.1, 1.0, and 2.0 microg/microl, each for 8 days. Males (n=8/group) showed the highest levels of operant behavior for injectable steroids (drostanolone, nandrolone) compared with orally active androgens (oxymetholone, stanozolol). For nandrolone, responses on the active and inactive nose-pokes averaged 22.3 +/- 4.6/4 hr and 10.7 +/- 2.0/4 hr, respectively. Responding for drostanolone was similar. Males self-administering oxymetholone or stanozolol did not prefer the active nose-poke. These data demonstrate that injectable androgens are more reinforcing than oral steroids.
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Cortney L
CL
Ballard
Ruth I
RI
Wood
D000704:Analysis of Variance; D000728:Androgens / Q000008:administration & dosage*; D000732:Androstanols / Q000008:administration & dosage; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003216:Conditioning, Operant / Q000187:drug effects*; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D004333:Drug Administration Routes; D005106:Exploratory Behavior / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D009277:Nandrolone / Q000008:administration & dosage; D010110:Oxymetholone / Q000008:administration & dosage; D012054:Reinforcement, Psychology; D012646:Self Administration / Q000379:methods; D013197:Stanozolol / Q000008:administration & dosage; D019966:Substance-Related Disorders / Q000503:physiopathology*; D013997:Time Factors
D000728:Androgens; D000732:Androstanols; D013197:Stanozolol; D009277:Nandrolone; C100263:dromostanolone; D010110:Oxymetholone