Taxezopidines M and N, taxoids from the Japanese yew, Taxus cuspidata.
Two new taxoids, taxezopidines M (1) and N (2), have been isolated from seeds of the Japanese yew, Taxus cuspidata, and new structures were elucidated on the basis of spectroscopic data. The absolute configuration of a 3-N,N-(dimethylamino)-3-phenylpropanoyl group in 1 and 2 was determined to be R in each case by chiral HPLC analysis. The effect of 1 and 2 on the CaCl(2)-induced depolymerization of microtubules was investigated.
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Hiroshi
H
Morita
Izumi
I
Machida
Yusuke
Y
Hirasawa
Jun'ichi
J
Kobayashi
D002122:Calcium Chloride / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D007564:Japan; D008870:Microtubules / Q000187:drug effects; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D043823:Taxoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020946:Taxus / Q000737:chemistry*
D043823:Taxoids; C502714:taxezopidine M; C502713:taxezopidine N; D002122:Calcium Chloride