[Distribution of gama-aminobutyric acid (GABA)ergic neurons in rats cochlear nuclei after unilateral cochlea ablation].
OBJECTIVE
To observe the distribution of gama-aminobutyric acid (GABA) ergic neurons in rats cochlear nuclei (CN) in pre-and post-operation of unilateral cochlea ablation.


METHODS
The technique of direct anti-GABA immunocytochemistry (SP) was used in this study.


RESULTS
The GABAergic neurons existed extensively in cochlear nuclei(CN). The number was more, the volume was larger of GABAergic cells in CN and those cells were stained heavily before ablation. The number of GABAergic cells in lesion side was far less than that in intact side after unilateral cochlea ablation one to two weeks (P < 0.01), then the number of GABAergic cells increased after three weeks which was still less (P > 0.05) and almost reached normal after a month (P > 0.05).


CONCLUSIONS
The changes of GABAergic neurons reflect the balance between excitatory and inhibitory of neurons. It suggests that changes in the extent of GABAergic inhibition have been shown to contribute to the reorganization of primary auditory central system after unilateral cochlea ablation in rats. The decrease and increase of the number of GABAergic-neurons are essential for this reorganization.
Department of Otolaryngology-Head and Neck Surgery, People's Hospital of Wuhan University, Wuhan, 430060, China. jasp@public.wh.hb.cn
Qingquan
Q
Hua
Qinying
Q
Wang
Bokui
B
Xiao
D000818:Animals; D003051:Cochlea / Q000601:surgery*; D017626:Cochlear Nucleus / Q000378:metabolism*; D005260:Female; D008297:Male; D009474:Neurons / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid