Association between psychoactive medications and delirium in hospitalized patients: a critical review.
Psychoactive medications are often reported as delirium risk factors in hospitalized patients, and delirium induced by medication is potentially avoidable. The authors critically reviewed the evidence for a role of medications in delirium etiology. Only a few positive associations were noted. Use of psychoactive medications, considered together as a single variable, and use of opioids increased the risk of delirium. Data were scarce and sometimes conflicting, and methodological limitations were often present. The suspected association between psychoactive drugs and delirium cannot be unambiguously confirmed with current epidemiological evidence. The interpretation of these results must take into account the limitations of published studies, which should be addressed in future research.
Centre de Recherche end Cancérologie de L'Hôtel-Dieu de Québec, Quebec City, Canada.
Jean-David
JD
Gaudreau
Pierre
P
Gagnon
Marc-André
MA
Roy
François
F
Harel
Annie
A
Tremblay
D003693:Delirium / Q000139:chemically induced* / Q000453:epidemiology; D006760:Hospitalization; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy* / Q000534:rehabilitation; D011619:Psychotropic Drugs / Q000009:adverse effects*
D011619:Psychotropic Drugs