Mutasynthesis of rapamycin analogues through the manipulation of a gene governing starter unit biosynthesis.
Gregory
Matthew A
MA
Biotica Technology Ltd, Chesterford Research Park, Little Chesterford, Near Saffron Walden, UK.
Petkovic
Hrvoje
H
Lill
Rachel E
RE
Moss
Steven J
SJ
Wilkinson
Barrie
B
Gaisser
Sabine
S
Leadlay
Peter F
PF
Sheridan
Rose M
RM
D002384:Catalysis; D003066:Coenzyme A Ligases / Q000737:chemistry; D008968:Molecular Conformation; D048630:Polyketide Synthases / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D020123:Sirolimus / Q000737:chemistry / Q000378:metabolism*; D013237:Stereoisomerism; D013302:Streptomyces / Q000378:metabolism
D048630:Polyketide Synthases; D003066:Coenzyme A Ligases; D020123:Sirolimus