Association of deranged adrenal steroid metabolism with anemia in chronic heart failure.
The relation between adrenal steroid hormone imbalance, as quantified by the cortisol/dehydroepiandrosterone (DHEA) ratio, and hemoglobin concentrations was appraised in 92 men with stable chronic heart failure (CHF). The cortisol/DHEA ratio was independently and inversely associated with hemoglobin concentrations, suggesting that alterations of the steroid milieu may play a role in the pathogenesis of anemia in CHF.
Okonko
Darlington O
DO
Clinical Cardiology, National Heart and Lung Institute, Imperial College, London, UK. do.okonko@ic.ac.uk
Crosato
Martino
M
Kalra
Paul R
PR
Cicoira
Mariantonietta
M
John
Matthias
M
Doehner
Wolfram
W
Coats
Andrew J S
AJ
Poole-Wilson
Philip A
PA
Anker
Stefan D
SD
D000311:Adrenal Glands / Q000502:physiology; D000368:Aged; D000740:Anemia / Q000209:etiology* / Q000503:physiopathology; D003687:Dehydroepiandrosterone / Q000097:blood* / Q000378:metabolism; D006333:Heart Failure / Q000150:complications*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D006854:Hydrocortisone / Q000097:blood* / Q000378:metabolism; D008297:Male; D008875:Middle Aged
D006454:Hemoglobins; D003687:Dehydroepiandrosterone; D006854:Hydrocortisone