[Plasma and milk concentrations of acenocoumarin in breast-feeding women during post partum].
BACKGROUND
Patients are receiving anticoagulants during postpartum. Literature data still is controversy in milk excretion of acenocoumarin; there are conducts in favor and against. Because of the benefits of maternal milk it's necessary to probe if acenocoumarin is excreted by human milk.


OBJECTIVE
To determine the milk excretion of acenocoumarin in different periods of the postpartum and the milk excretion index in anticoagulant women.


METHODS
It's an observational, descriptive and prospective study. The milk and plasma concentrations of acenocoumarin were determined in breast-feeding mothers with anticoagulation during the postpartum. ANOVA was used to determine the differences in pharmacokinetic constants in the different days of study.


RESULTS
Two patients required light anticoagulation, nine moderate and five intense. The 37.5% of the new born were full term hypotrophy and the 18.75% were preterm. The highest plasma average concentration of acenocoumarin was found in day 45th postpartum (0.21 microg/mL). Acenocoumarin present in milk was found until day 30th; the average concentrations were low 0.011 microg/mL. The value of the maternal milk excretion index was 0.057 in day 45, what represents that approximately the 5% of acenocoumarin is eliminated by milk. The calculated dose of acenocoumarin that a new born could receive through maternal milk was lower than the recommended doses (1.79 microg/kg/day).


CONCLUSIONS
These results allowed us to recommend breastfeeding in patients who are been anticoagulated with acenocoumarin.
Instituto Nacional de Perinatología, Lomas Virreyes, México.
Luis Eduardo Romero
LE
Nava
Aurora Belmont
AB
Gómez
Victor Manuel Vidal
VM
González
D000074:Acenocoumarol / Q000493:pharmacokinetics*; D000284:Administration, Oral; D000328:Adult; D000925:Anticoagulants / Q000493:pharmacokinetics*; D001942:Breast Feeding; D005260:Female; D006801:Humans; D007774:Lactation / Q000378:metabolism; D008895:Milk, Human / Q000737:chemistry* / Q000378:metabolism; D010949:Plasma / Q000737:chemistry* / Q000378:metabolism; D049590:Postpartum Period; D011247:Pregnancy; D011446:Prospective Studies
D000925:Anticoagulants; D000074:Acenocoumarol