[A case of osteoclast-like giant cell tumor of the pancreas].
Osteoclast-like giant cell tumor of the pancreas is a very rare tumor. Despite their striking morphologic resemblance to certain mesenchymal tumors of bone and tendon sheath, it has been suggested that these tumors may arise from epithelial precursors. This unusual tumor presents in the 6th or 7th decade with a nearly equal gender ratio. Pure forms of osteoclast-like giant cell tumor have a better prognosis because they have a predilection to local spread, are slower to metastasize and rarely metastasize to lymph nodes, but these forms are very rare. We present an osteoclast-like giant cell tumor arising in the body of the pancreas in a 71 year-old male patient. The tumor was composed of two major cell types: atypical mononuclear cells and abundant osteoclast-like multinucleated giant cells. Immunohistochemical studies showed that atypical cells were strongly reactive for vimentin and focally reactive for cytokeratin. In contrast, the giant cells were immunoreactive for CD68, but negative for cytokeratin. Three months later, the tumor size increased and liver metastasis was newly developed. He died at 11 months after the diagnosis.
Cho
Sang Hyung
SH
Center for Liver Cancer, National Cancer Center, Goyang-si, Gyeonggi-do, Korea.
Cheon
Jae Hee
JH
Lee
Sang Won
SW
Park
Hong Suk
HS
Kim
Seong Hoon
SH
Park
Sang Jae
SJ
Lee
Woo Jin
WJ
Hong
Eun Kyung
EK
Park
Joong Won
JW
D000368:Aged; D005870:Giant Cell Tumors / Q000473:pathology*; D006801:Humans; D008297:Male; D010010:Osteoclasts / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000473:pathology*