Role of transrectal ultrasound guided salvage cryosurgery for recurrent prostate carcinoma after radiotherapy.
Despite improvements in treatment of localized prostate cancer, local recurrence remains a significant problem. A total of 46 patients with proven local cancer recurrence following external beam radiotherapy entered a prospective clinical trial using ultrasound-guided cryosurgery to ablate the residual prostate gland. Persistent complications included one urethra-rectal fistula, incontinence (2), retention (3), and treatment induced erectile dysfunction (7). Using the PSA definitions for biochemical failure as PSA>or=0.3 ng/ml, the Kaplan-Meier plots showed the incidence of patients to be free of biochemical recurrence at 51 and 44% at 1 and 2 y, respectively. For a PSA>or=1.0, the values at 1 and 2 y were 72 and 58%.
Department of Surgery, University of Calgary, Calgary Regional Health Authority, Calgary, Alberta, Canada.
B J
BJ
Donnelly
J C
JC
Saliken
D S
DS
Ernst
B
B
Weber
J W
JW
Robinson
P M A
PM
Brasher
M
M
Rose
J
J
Rewcastle
D000368:Aged; D001918:Brachytherapy; D003287:Contrast Media / Q000494:pharmacology; D003452:Cryosurgery / Q000379:methods*; D017679:Cryotherapy; D007172:Erectile Dysfunction; D005500:Follow-Up Studies; D019786:Gadolinium DTPA / Q000494:pharmacology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009364:Neoplasm Recurrence, Local; D011446:Prospective Studies; D011467:Prostate / Q000000981:diagnostic imaging / Q000378:metabolism; D017430:Prostate-Specific Antigen / Q000096:biosynthesis; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000601:surgery*; D011878:Radiotherapy / Q000379:methods*; D012008:Recurrence; D016879:Salvage Therapy; D013997:Time Factors; D014463:Ultrasonography
D003287:Contrast Media; D017430:Prostate-Specific Antigen; D019786:Gadolinium DTPA