Databases and software for the comparison of prokaryotic genomes.
The explosion in the number of complete genomes over the past decade has spawned a new and exciting discipline, that of comparative genomics. To exploit the full potential of this approach requires the development of novel algorithms, databases and software which are sophisticated enough to draw meaningful comparisons between complete genome sequences and are widely accessible to the scientific community at large. This article reviews progress towards the development of computational tools and databases for organizing and extracting biological meaning from the comparison of large collections of genomes.
Field
Dawn
D
Oxford Centre for Ecology and Hydrology, Mansfield Road, Oxford OX1 3SR, UK.
Feil
Edward J
EJ
Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK.
Wilson
Gareth A
GA
Oxford Centre for Ecology and Hydrology, Mansfield Road, Oxford OX1 3SR, UK.
D019295:Computational Biology; D030561:Databases, Nucleic Acid; D030562:Databases, Protein; D016680:Genome, Bacterial; D023281:Genomics; D016415:Sequence Alignment; D012984:Software