A potential role of the curry spice curcumin in Alzheimer's disease.
There is substantial in-vitro data indicating that curcumin has antioxidant, anti-inflammatory, and anti-amyloid activity. In addition, studies in animal models of Alzheimer's disease (AD) indicate a direct effect of curcumin in decreasing the amyloid pathology of AD. As the widespread use of curcumin as a food additive and relatively small short-term studies in humans suggest safety, curcumin is a promising agent in the treatment and/or prevention of AD. Nonetheless, important information regarding curcumin bioavailability, safety and tolerability, particularly in an elderly population is lacking. We are therefore performing a study of curcumin in patients with AD to gather this information in addition to data on the effect of curcumin on biomarkers of AD pathology.
University of California, Los Angeles, Department of Neurology, Alzheimer's Disease Research Center, Los Angeles, CA 90095, USA. jringman@mednet.ucla.edu
John M
JM
Ringman
Sally A
SA
Frautschy
Gregory M
GM
Cole
Donna L
DL
Masterman
Jeffrey L
JL
Cummings
D000544:Alzheimer Disease / Q000188:drug therapy* / Q000517:prevention & control; D000818:Animals; D017322:Clinical Trials, Phase II as Topic / Q000379:methods; D030024:Curcuma; D003474:Curcumin / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D006801:Humans; D008517:Phytotherapy / Q000379:methods; D017365:Spices
D003474:Curcumin