American Association for Cancer Research 1997: progress and new hope in the fight against cancer.
Considerable progress has been made with tyrosine kinase inhibitors. After long and sustained efforts, several tyrosine kinase inhibitors with convincing in vivo experimental antitumour properties such as CP-358,774, ZD 1839, CEP-751 are entering Phase I clinical trials. Significant in vivo experimental antitumour activity has also been described for two new families of farnesyl transferase inhibitors (SCH 59228 and PD 083176 series). Novel inhibitors of tubulin polymerisation are on the verge of entering clinical trials. These include F12458, an analogue of vinorelbine, and C52/C55 cryptophycin derivatives.
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Rhone-Poulenc Rorer SA, Centre de Recherche de Vitry-Alfortville, F94403 Vitry-sur-Seine Cedex, France.