A simplified laminin nomenclature.
A simplification of the laminin nomenclature is presented. Laminins are multidomain heterotrimers composed of alpha, beta and gamma chains. Previously, laminin trimers were numbered with Arabic numerals in the order discovered, that is laminins-1 to -5. We introduce a new identification system for a trimer using three Arabic numerals, based on the alpha, beta and gamma chain numbers. For example, the laminin with the chain composition alpha5beta1gamma1 is termed laminin-511, and not laminin-10. The current practice is also to mix two overlapping domain and module nomenclatures. Instead of the older Roman numeral nomenclature and mixed nomenclature, all modules are now called domains. Some domains are renamed or renumbered. Laminin epidermal growth factor-like (LE) domains are renumbered starting at the N-termini, to be consistent with general protein nomenclature. Domain IVb of alpha chains is named laminin 4a (L4a), domain IVa of alpha chains is named L4b, domain IV of gamma chains is named L4, and domain IV of beta chains is named laminin four (LF). The two coiled-coil domains I and II are now considered one laminin coiled-coil domain (LCC). The interruption in the coiled-coil of beta chains is named laminin beta-knob (Lbeta) domain. The chain origin of a domain is specified by the chain nomenclature, such as alpha1L4a. The abbreviation LM is suggested for laminin. Otherwise, the nomenclature remains unaltered.
Aumailley
Monique
M
Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany.
Bruckner-Tuderman
Leena
L
Carter
William G
WG
Deutzmann
Rainer
R
Edgar
David
D
Ekblom
Peter
P
Engel
Jürgen
J
Engvall
Eva
E
Hohenester
Erhard
E
Jones
Jonathan C R
JC
Kleinman
Hynda K
HK
Marinkovich
M Peter
MP
Martin
George R
GR
Mayer
Ulrike
U
Meneguzzi
Guerrino
G
Miner
Jeffrey H
JH
Miyazaki
Kaoru
K
Patarroyo
Manuel
M
Paulsson
Mats
M
Quaranta
Vito
V
Sanes
Joshua R
JR
Sasaki
Takako
T
Sekiguchi
Kiyotoshi
K
Sorokin
Lydia M
LM
Talts
Jan F
JF
Tryggvason
Karl
K
Uitto
Jouni
J
Virtanen
Ismo
I
von der Mark
Klaus
K
Wewer
Ulla M
UM
Yamada
Yoshihiko
Y
Yurchenco
Peter D
PD
D000818:Animals; D006801:Humans; D007797:Laminin / Q000737:chemistry* / Q000145:classification*; D009626:Terminology as Topic
D007797:Laminin