Contrast-enhanced ultrasonography better identifies pancreatic tumor vascularization than helical CT.
BACKGROUND
Contrast-enhanced ultrasonography (CEUS) is a recently introduced field of ultrasonography (US). To assess the ability of CEUS to identify the vascularization of solid pancreatic tumors in comparison to helical CT.


METHODS
Forty-two resected pancreatic tumors, found at US, were studied with CEUS and helical CT. The tumor enhancement at CEUS was scored in comparison to the baseline aspect of the lesion and/or the extralesional pancreatic parenchyma together with the adjacent vessels during the dynamic study. All the lesions underwent pathological examination using H&E stains and CD34 markers with an evaluation of the microvessel density (MVD). The correlation of CEUS and helical CT with the MVD of the lesions was established with Spearman's test.


RESULTS
The correlation of CEUS with the MVD of the lesions was significantly superior (Rs = 0.914; p < 0.0001) to that of helical CT (Rs = 0.635; p < 0.0001).


CONCLUSIONS
CEUS is better than helical CT in the identification of the vascularization of solid pancreatic tumors. CEUS, when the pancreatic gland is optimally visualized, should be therefore considered a complementary imaging modality in the characterization of pancreatic tumors. CEUS can be a valid onco-imaging modality for quantifying tumoral vascularization in a noninvasive and accurate way.
D'Onofrio
Mirko
M
Department of Radiology, Policlinico G.B. Rossi, University of Verona, Verona, Italy. mirkodonofrio@libero.it
Malagò
Roberto
R
Zamboni
Giulia
G
Vasori
Simone
S
Falconi
Massimo
M
Capelli
Paola
P
Mansueto
Giancarlo
G
D000230:Adenocarcinoma / Q000098:blood supply* / Q000473:pathology / Q000601:surgery; D008833:Microcirculation; D010190:Pancreatic Neoplasms / Q000098:blood supply* / Q000473:pathology / Q000601:surgery; D010743:Phospholipids / Q000008:administration & dosage*; D011446:Prospective Studies; D015203:Reproducibility of Results; D013459:Sulfur Hexafluoride / Q000008:administration & dosage*; D036542:Tomography, Spiral Computed / Q000379:methods*; D014463:Ultrasonography / Q000379:methods*
D010743:Phospholipids; C420843:contrast agent BR1; D013459:Sulfur Hexafluoride