The usefulness of single nucleotide polymorphisms (SNPs) for genetic epidemiological investigation of complex psychiatric diseases.
The genetic epidemiology of complex psychiatric diseases has become a much studied and very prospering field. It is widely believed that many genetic factors contribute to the various phenotypes and diseases, with overall contributions of a single factor being comparatively minor. The study of choice in such settings is the investigation of allelic association, which may be performed in a variety of ways. Here single nucleotide polymorphisms are an indispensable tool.
Müller-Myhsok
Bertram
B
Max-Planck-Insitute of Psychiatry, Kraepelinstr. 2-10, D-80689 München, Germany. bmm@mpipsykl.mpg.de
D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D001523:Mental Disorders / Q000453:epidemiology / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012306:Risk