The effects of plasma insulin and glucose on myocardial blood flow in patients with type 1 diabetes mellitus.
OBJECTIVE
The objective of this study was to determine the impact of insulin and glucose on myocardial vasodilator function in patients with type 1 diabetes mellitus (T1DM).


BACKGROUND
The relative importance of plasma insulin and glucose levels on the abnormal vasodilator function observed in T1DM is unknown.


METHODS
Twenty T1DM patients underwent positron emission tomography studies to measure myocardial blood flow (MBF) (in ml/g/min) at rest (MBFr) and during adenosine (MBFa), both under baseline metabolic conditions and then during either hyperinsulinemic-euglycemic clamp (HE) (n = 10; 40 +/- 9 years, 8 female subjects, hemoglobin A1c [HbA1c] 7.8 +/- 1.1%) or hyperinsulinemic-hyperglycemic clamp (HH) (n = 10; 44 +/- 12 years, 8 female subjects, hemoglobin A1c 7.7 +/- 0.6%).


RESULTS
Both groups showed similar MBFr and MBFa under baseline metabolic conditions (p = NS). Compared with baseline conditions, MBFr increased in the HH group (p < 0.005), whereas it did not change in the HE group. Compared with baseline conditions, MBFa decreased in the HH group (p < 0.05) but did not change in the HE group. Myocardial perfusion reserve (MPR) (MBFa/MBFr) was similar between the HE and HH groups at baseline (p = NS). During clamp, MPR tended to decrease in the HH group (p < 0.1) but did not change in the HE group (p = NS) when compared with baseline conditions. However, during the clamp MPR was significantly lower in the HH group when compared with the HE group (p < 0.0001).


CONCLUSIONS
In the short term, hyperglycemia has a deleterious effect on myocardial vasodilator function, which outweighs the beneficial effect of hyperinsulinemia.
Srinivasan
Muthayyah
M
Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Herrero
Pilar
P
McGill
Janet B
JB
Bennik
Jasper
J
Heere
Bastiaan
B
Lesniak
Donna
D
Davila-Roman
Victor G
VG
Gropler
Robert J
RJ
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000502:physiology*; D003326:Coronary Circulation / Q000502:physiology*; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000503:physiopathology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D015309:Glucose Clamp Technique; D006801:Humans; D007328:Insulin / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D014664:Vasodilation / Q000502:physiology*
D001786:Blood Glucose; D007328:Insulin