Annuloaortic ectasia and giant cell arteritis.
BACKGROUND
Thoracic aortic aneurysm, aortic dissection and aortic valve regurgitation have been widely described in patients with Horton disease, also known as giant cell arteritis. We present our midterm experience with patients with these features.


METHODS
A total of 386 cases of ascending aorta and aortic valve replacement performed for thoracic aortic aneurysm and aortic insufficiency between 1998 and 2004 were reviewed. Among them 10 cases of histopathologically confirmed GAA were identified. Patients were predominantly female (90%); the mean age was 74.5 +/- 4.6 years.


RESULTS
Eight patients (80%) showed typical annuloaortic ectasia, leading to significant aortic valve regurgitation. These subjects underwent a Bentall operation. Two patients whose sinuses seemed undilated and macroscopically normal had separate valve graft replacement at first operation and underwent reoperation due to dilatation of the native sinuses. Eight patients had partial aortic arch replacement (hemiarch), and 1 underwent total arch replacement. Six-year survival was 0.9 +/- 0.09; freedom from reoperation at 6 years was 0.77 +/- 0.13.


CONCLUSIONS
Annuloaortic ectasia is a common finding in giant cell arteritis. In patients with Horton disease, the aortic root should always be replaced regardless of macroscopic findings.
Department of Cardiac Surgery, Careggi Hospital, Florence, Italy. sandrogelsomino@virgilio.it
Sandro
S
Gelsomino
Stefano
S
Romagnoli
Franca
F
Gori
Gabriella
G
Nesi
Chiara
C
Anichini
Carlo
C
Sorbara
Pierluigi
P
Stefàno
Gian Franco
GF
Gensini
D000368:Aged; D000369:Aged, 80 and over; D017545:Aortic Aneurysm, Thoracic / Q000209:etiology / Q000601:surgery*; D001022:Aortic Valve Insufficiency / Q000209:etiology / Q000601:surgery*; D013504:Cardiovascular Surgical Procedures; D004108:Dilatation, Pathologic; D005260:Female; D013700:Giant Cell Arteritis / Q000150:complications / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D012189:Retrospective Studies