[Lead-induced pathomechanisms of hypertension].
Based on the literature, the study presents lead-induced mechanisms of hypertension development. The investigations performed hitherto, demonstrate that exposure to lead causes the damage of endothelial vasodilating function as the result of free radicals increase and decrease of the organism antioxidative barrier, whereas hormonal and renal mechanisms seem to be secondary phenomenon.
Goch
Aleksander
A
Klinika Kardiologii i Nadciśnienia Tetniczego Instytutu Kardiologii Uniwersytetu Medycznego w Lodzi. kardiolog@skwam.lodz.pl
Goch
Jan Henryk
JH
D002986:Clinical Trials as Topic; D004730:Endothelium, Vascular / Q000503:physiopathology; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology; D007854:Lead / Q000009:adverse effects*; D018384:Oxidative Stress; D014664:Vasodilation
D005609:Free Radicals; D007854:Lead