Association between chronic periodontal disease and left ventricular hypertrophy in kidney transplant recipients.
Periodontal disease (PD) may cause a systemic inflammatory reaction and contribute to left ventricular hypertrophy (LVH) in hypertensive subjects. This study aimed to assess whether chronic PD may contribute to LVH in patients after kidney transplantation. The study analyzed 99 patients divided according to Community Periodontal Index of Treatment Needs (CPITN) score into patients with advanced PD (CPITN 3-4) and patients without or with moderate periodontal lesions (CPITN 0-2). Patients with CPITN 3 to 4 were characterized by a significantly higher plasma high-sensitivity C-reactive protein (HS-CRP) concentration (6.2+/-2.2 vs. 1.7+/-0.3 mg/L, P<0.05) and left ventricular mass index (LVMI) (150+/-7 vs. 111+/-3 g/m, P<0.001) in comparison with patients with CPITN 0 to 2. In the multiple regression model, LVMI was dependent on CPITN (P<0.001), HS-CRP (P<0.05), serum cholesterol (P<0.05), and creatinine concentration (P<0.05). In conclusion, it appears that advanced PD in patients after kidney transplantation is associated with LVH.
Department of Nephrology, Endocrinology and Metabolic Diseases, Silesian University School of Medicine in Katowice, Katowice, Poland. Edward.Franek@cskmswia.pl
Edward
E
Franek
Anna
A
Blach
Artur
A
Witula
Aureliusz
A
Kolonko
Jerzy
J
Chudek
Jan
J
Drugacz
Andrzej
A
Wiecek
D000328:Adult; D002908:Chronic Disease; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000453:epidemiology* / Q000209:etiology; D007249:Inflammation; D016030:Kidney Transplantation; D010510:Periodontal Diseases / Q000150:complications*; D011183:Postoperative Complications / Q000503:physiopathology*; D012044:Regression Analysis; D012307:Risk Factors; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*