[A study on space mutation of Streptomyces fradiae].
OBJECTIVE
To study the rule of mutation of Streptomyces fradiae during spaceflight, and to select efficient tylosin producing strains for industrial production.


METHODS
Streptomyces fradiae 9940S(+)-86 were carried on-board spaceship "Shenzhou" I, "Shenzhou" III and "Shenzhou" IV sequentially to achieve spaceflight mutation breeding experiment.


RESULTS
After space experiments and the screening tests in the lab, 48 strains were obtained which promoted production by +20% or more at shaker level. And the highest production of a strain was 14950 micrograms/ml, which means an increase of 91.5%.


CONCLUSIONS
Comparing the results of three tests, it is found that the outer space environment can lead to a cumulative mutation. After the medium scale tests and production experiments, strain T1-156-84-23 was finally selected to be used for sample production. And its output was increased by 18%.
Fang
Xiao-mei
XM
Dawn Aerospace Technology Co., Ltd, Beijing, China. annie@dawnat.com
Zhao
Zhi-jia
ZJ
Gu
Hai-ke
HK
D009154:Mutation; D013026:Space Flight; D013302:Streptomyces / Q000235:genetics* / Q000378:metabolism; D015645:Tylosin / Q000096:biosynthesis*; D014893:Weightlessness
D015645:Tylosin