[The cytogenic status of peripheral lymphocytes in pulmonary tuberculosis before and during chemotherapy].
The cytogenic status of peripheral lymphocytes was studied in 67 patients with drug-sensitive pulmonary tuberculosis. The latter was found to be attended by cytogenetic disorganization whose signs were present before and 2 months of intensive chemotherapy. In pulmonary tuberculosis, structural disorganization in the lymphocytic chromosomal apparatus was characterized by the elevated levels of cells and with changes in the structure and number of chromosomes. They are most pronounced in infiltrative and disseminated tuberculosis than in caseous pneumonia, as well as 2 months after rather than before chemotherapy. Patients with infiltrative pulmonary tuberculosis had also decreased lymphocytic activity of DNA reparation, followed by its normalization after a course of chemotherapy.
Novitskiĭ
V V
VV
Strelis
A K
AK
Urazova
O I
OI
Luk'ianova
T A
TA
Riabova
E A
EA
Esimova
I E
IE
Voronkova
O V
OV
Sinitsyna
V A
VA
Filiniuk
O V
OV
Zemlianaia
N A
NA
D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D018929:Cell Culture Techniques; D002467:Cell Nucleus / Q000187:drug effects / Q000235:genetics* / Q000648:ultrastructure; D004247:DNA / Q000032:analysis* / Q000187:drug effects; D005500:Follow-Up Studies; D005819:Genetic Markers; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D014397:Tuberculosis, Pulmonary / Q000097:blood* / Q000188:drug therapy / Q000235:genetics
D000995:Antitubercular Agents; D005819:Genetic Markers; D004247:DNA