Mammalian sterile 20-like kinases in tumor suppression: an emerging pathway.
Emerging evidence suggests that the proapoptotic kinase mammalian sterile 20-like kinase 2 (MST2) acts in a novel tumor suppression pathway. Recently, we showed that Raf-1 kinase sequesters and inhibits MST2 and that this event is critical for Raf-mediated cell survival. In this review, we summarize Raf control of MST2 and we outline a novel pathway involving the downstream effector proteins Salvador and Warts/Lats that may act to limit the positive effects of Raf-mitogen-activated protein kinase signaling in cancer cells.
O'Neill
Eric E
EE
Beatson Insitute for Cancer Research, University of Glasgow, Glasgow, United Kingdom.
Matallanas
David
D
Kolch
Walter
W
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D009369:Neoplasms / Q000201:enzymology* / Q000473:pathology; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D019908:Proto-Oncogene Proteins c-raf / Q000378:metabolism; D000090742:Serine-Threonine Kinase 3; D000099317:Hippo Kinases
D047908:Intracellular Signaling Peptides and Proteins; D017346:Protein Serine-Threonine Kinases; D019908:Proto-Oncogene Proteins c-raf; D000090742:Serine-Threonine Kinase 3; C490660:Stk4 protein, mouse; D000099317:Hippo Kinases; C095566:STK4 protein, human; C097835:STK3 protein, human; C490818:Stk3 protein, mouse