Formation of lanthanide(III) texaphyrin complexes with DNA controlled by the size of the central metal cation.
Interaction of lanthanide(III) texaphyrins (LnTEX) with calf thymus DNA was studied by UV-Vis, CD, resonance light scattering spectroscopy and by laser flash photolysis. The thermal stability of the LnTEX/DNA complexes decreases with the increasing lanthanide ion radius: LuTEX>DyTEX>GdTEX>EuTEX>CeTEX> or =LaTEX. Texaphyrins LaTEX, LuTEX and GdTEX produce O2(1Deltag) in methanol solutions. In a phosphate buffer, the concentration of O2(1Deltag) produced by these texaphyrins bound to DNA is affected by the formation of aggregates on the DNA backbone.
J. Heyrovský Institute of Physical Chemistry, Academy of Sciences of the Czech Republic, Dolejskova 3, 18223 Praha 8, Czech Republic. kubat@jh-inst.cas.cz
Pavel
P
Kubát
Kamil
K
Lang
Zdenek
Z
Zelinger
Vladimír
V
Král
D000818:Animals; D002412:Cations / Q000737:chemistry; D002417:Cattle; D004247:DNA / Q000737:chemistry*; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D015394:Molecular Structure; D011166:Porphyrins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013057:Spectrum Analysis; D013696:Temperature
D002412:Cations; D028581:Lanthanoid Series Elements; D011166:Porphyrins; C442892:texaphyrin; D004247:DNA; C427203:calf thymus DNA