Hepatic injury in a patient taking rosiglitazone.
We describe a 52-year-old man with type 2 diabetes mellitus who developed cholestatic hepatitis in association with rosiglitazone use. Liver biopsy findings included dilated canaliculi, inspissated bile, intrahepatocellular bile pigment deposits, and enlarged xanthomatous Kupffer cells. The form of liver injury reported in this case differs markedly from those reported previously for rosiglitazone.
Veterans Affairs Medical Center and University of Michigan Medical School Ann Arbor, MI 48105-2300, USA.
Stacy B
SB
Menees
Michelle A
MA
Anderson
Stephen W
SW
Chensue
Richard H
RH
Moseley
D001706:Biopsy; D056487:Chemical and Drug Induced Liver Injury, Chronic / Q000209:etiology* / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000009:adverse effects* / Q000627:therapeutic use
D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D000077154:Rosiglitazone