Structure-function relationships within Keppler-type antitumor ruthenium(III) complexes: the case of 2-aminothiazolium[trans-tetrachlorobis(2-aminothiazole)ruthenate(III)].
Keppler-type ruthenium(III) complexes exhibit promising antitumor properties. We report here a study of 2-aminothiazolium[trans-tetrachlorobis(2-aminothiazole)ruthenate(III)], both in the solid state and in solution. The crystal structure has been solved and found to exhibit classical features. Important solvatochromic effects were revealed. Notably, we observed that introduction of an amino group in position 2 greatly accelerates chloride hydrolysis compared to the thiazole analogue; this latter finding may be of interest for a fine-tuning of the reactivity of these novel metallodrugs.
Institute of Crystallography sezione di Monterotondo, Area della Ricerca di Roma, CNR, CP10, I-00016 Monterotondo Stazione, Rome, Italy. Pasquale.Mura@ic.cnr.it
Pasquale
P
Mura
Francesca
F
Piccioli
Chiara
C
Gabbiani
Mercedes
M
Camalli
Luigi
L
Messori
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D007941:Leukemia P388; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
C503651:2-aminothiazolium(trans-tetrachlorobis(2-aminothiazole)ruthenate(III)); D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D013844:Thiazoles; D012428:Ruthenium