Inhibitors of membrane receptors involved with leukocyte extravasation.
The migration of leukocytes from the blood stream to sites of infection is a key event in cellular immune response, mediated by multiple types of molecules including several adhesion receptors. The inhibition of adhesion receptors holds great promise for novel therapeutical strategies to treat chronic inflammatory disorders or autoimmune diseases. This review reports on recent advances in adhesion-based therapeutics and focuses on structural classification of selectin and integrin inhibitors.
Rheinische Friedrich-Wilhelms-University Bonn, Institute of Pharmaceutical Chemistry, Department of Pharmacy, An der Immenburg 4, 53121 Bonn, Germany. gbendas@uni-bonn.de
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Bendas
D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism; D002465:Cell Movement / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000037:antagonists & inhibitors / Q000502:physiology; D007962:Leukocytes / Q000378:metabolism* / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology*; D019087:Selectins / Q000502:physiology
D015815:Cell Adhesion Molecules; D016023:Integrins; D011956:Receptors, Cell Surface; D019087:Selectins