E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis.
Three hundred seven patients with MS and 300 controls were genotyped for G98T and A561C SNPs in the E-selectin gene, and genetic data were correlated with the course of the disease. The frequency of the T/T genotype of the G98T SNP was significantly increased in RR-MS patients compared with controls, while was absent in PP-MS. The frequency of the A561C SNP was significantly decreased in SP-MS compared with benign RR-MS. The T/T genotype of the G98T SNP is likely to confer an increased risk to develop MS. The A561C polymorphism seems to act as protective factor towards the progression to SP-MS.
Department of Neurological Sciences, "Dino Ferrari" Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F. Sforza, 35, 20122, Milan, Italy. daniela.galimbert@unimi.it
Daniela
D
Galimberti
Chiara
C
Fenoglio
Raffaella
R
Clerici
Cristoforo
C
Comi
Milena
M
De Riz
Mariarosa
M
Rottoli
Laura
L
Piccio
Marco
M
Ronzoni
Eliana
E
Venturelli
Francesco
F
Monaco
Marco
M
Poloni
Nereo
N
Bresolin
Elio
E
Scarpini
D000227:Adenine Nucleotides / Q000235:genetics; D000328:Adult; D003597:Cytosine Nucleotides / Q000235:genetics; D018450:Disease Progression; D019040:E-Selectin / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006150:Guanine Nucleotides / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D020641:Polymorphism, Single Nucleotide; D013942:Thymine Nucleotides / Q000235:genetics
D000227:Adenine Nucleotides; D003597:Cytosine Nucleotides; D019040:E-Selectin; D006150:Guanine Nucleotides; D013942:Thymine Nucleotides