Androgen regulation of satellite cell function.
Androgen treatment can enhance the size and strength of muscle. However, the mechanisms of androgen action in skeletal muscle are poorly understood. This review discusses potential mechanisms by which androgens regulate satellite cell activation and function. Studies have demonstrated that androgen administration increases satellite cell numbers in animals and humans in a dose-dependent manner. Moreover, androgens increase androgen receptor levels in satellite cells. In vitro, the results are contradictory as to whether androgens regulate satellite cell proliferation or differentiation. IGF-I is one major target of androgen action in satellite cells. In addition, the possibility of non-genomic actions of androgens on satellite cells is discussed. In summary, this review focuses on exploring potential mechanisms through which androgens regulate satellite cells, by analyzing developments from research in this area.
Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria 3084, Australia.
Yue
Y
Chen
Jeffrey D
JD
Zajac
Helen E
HE
MacLean
D000375:Aging / Q000187:drug effects; D000728:Androgens / Q000502:physiology*; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D032446:Myoblasts / Q000166:cytology; D011944:Receptors, Androgen / Q000378:metabolism; D032496:Satellite Cells, Skeletal Muscle / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*
D000728:Androgens; D011944:Receptors, Androgen; D007334:Insulin-Like Growth Factor I