Lifestyle factors and the risk of adult leukemia in Canada.
OBJECTIVE
To evaluate the impact of active smoking, obesity, and dietary intakes on the risk of adult leukemia.


METHODS
We analysed data obtained from a population-based case-control study conducted in eight Canadian provinces. Risk estimates were generated by applying multivariate logistic regression methods to 1068 incident histologically confirmed leukemia cases and 5039 controls aged 20-74.


RESULTS
We found a statistically significant increased risk for acute myeloid leukemia (AML) associated with active smoking, with a clear dose-response relationship and an adjusted odds ratio (OR) of 1.5 (95% confidence interval [CI]=1.1-2.0) for heavy smokers reporting more than 20 pack-years of cigarette smoking. We also observed positive associations with the highest body mass index (BMI) for AML, chronic myeloid leukemia, and chronic lymphoid leukemia with a significant dose-response relationship. No association with leukemia was observed for the intake of fruits and vegetables, and the effect of active smoking on adult leukemia risk was not modified by fruits and/or vegetables consumption or obesity. However, the positive risk for AML associated with active smoking disappeared among subjects with high BMI (> or =30 kg/m2).


CONCLUSIONS
Our study contributes to the accumulating evidence linking AML and active smoking, and provides some evidence that obesity increases the risk of most of the adult leukemia subtypes.
Département de médecine sociale et préventive, Faculté de Médecine, Université Laval, Québec (Québec), Canada.
Khaled
K
Kasim
Patrick
P
Levallois
Belkacem
B
Abdous
Pierre
P
Auger
Kenneth C
KC
Johnson
D017677:Age Distribution; D001554:Benzene; D015992:Body Mass Index; D002170:Canada / Q000453:epidemiology; D016022:Case-Control Studies; D004032:Diet; D005260:Female; D005638:Fruit; D006801:Humans; D007938:Leukemia / Q000453:epidemiology*; D008019:Life Style; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000453:epidemiology; D016273:Occupational Exposure / Q000009:adverse effects; D011839:Radiation, Ionizing; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D012997:Solvents; D014028:Tobacco Smoke Pollution / Q000009:adverse effects; D014675:Vegetables
D012997:Solvents; D014028:Tobacco Smoke Pollution; D001554:Benzene