[Pathological and clinical correlations in primary cutaneous B-cell lymphomas: a series of 44 cases].
OBJECTIVE
histological and clinical relationship study of 44 cases of primary cutaneous B cell lymphoma, classified according to WHO classification.


METHODS
histological, immunological and molecular analysis was correlated with clinical data.


RESULTS
33 cases (75%) were marginal zone B-cell lymphomas (MZL), with head and trunk predominance (median age = 54 years). Relapses in other mucosa-related sites occurred in 3 patients. Histological transformation implied a more aggressive treatment in 3 cases. A favorable outcome was observed in most cases. 9 (20%) diffuse large B-cell lymphomas (DLBCL) appeared as a unique nodule, with female predominance (median age = 74 years) and 4 lymphoma-related deaths which seemed age-related (> 70 years) with only one lower limb localization. Histological aggressive features were present in 3 patients with a fatal outcome. 2 (5%) WHO grade 3 follicular lymphomas (FL) had an heterogeneous phenotype, with head localization, cutaneous relapses and good outcome.


CONCLUSIONS
MZL, the predominant type, has a good prognosis, although transformation can occur, needing a more aggressive treatment. DLBCL, observed in older patients, has clinical and histological prognostic factors identical to extra-cutaneous lymphomas. FL appears rare and has an heterogeneous phenotype. Relationships with its nodal counterpart remains unclear.
de la Fouchardière
Arnaud
A
Service d'Anatomie Pathologique, Hôpital Croix-Rousse, Lyon.
Balme
Brigitte
B
Chouvet
Brigitte
B
Perrot
Henri
H
Thomas
Luc
L
Claudy
Alain
A
Felman
Pascale
P
Salles
Gilles
G
Coiffier
Bertrand
B
Berger
Françoise
F
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D004273:DNA, Neoplasm / Q000032:analysis; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D008224:Lymphoma, Follicular / Q000235:genetics / Q000473:pathology / Q000628:therapy; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D016133:Polymerase Chain Reaction; D011878:Radiotherapy; D012074:Remission Induction; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D013514:Surgical Procedures, Operative
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm