Lipoxins in the eye and their role in wound healing.
The eye must contain highly evolved programs to limit inflammation and promote wound healing as an errant response can lead to blindness. However, pathways that protect the delicate visual axis and account for its atypical inflammatory responses remain to be clearly defined. Hence, research efforts have been initiated to elucidate the role of the anti-inflammatory LXA4 circuits in the eye. LXA4 is formed in healthy and injured corneas and both its receptor and 12/15-lipoxygenase are predominantly expressed in epithelial cells. An essential role for LXA4 in preserving ocular function is supported by 12/15-LOX deficient mice that exhibit a phenotype of impaired wound healing and LXA4 formation. A novel epithelial bioaction role for LXA4 has been uncovered in the cornea as topical LXA4 promotes wound healing and limits the sequelae of injury. These emerging studies indicate that the LXA4 circuit may hold a fundamental role in maintaining an ocular environment that actively restricts inflammation while promoting wound healing.
Department of Pharmacology, New York Medical College, Basic Science Building, Valhalla, NY 10595, USA. karsten_gronert@nymc.edu
Karsten
K
Gronert
D000818:Animals; D003315:Cornea / Q000503:physiopathology; D065306:Corneal Injuries; D005131:Eye Injuries / Q000378:metabolism / Q000503:physiopathology; D007249:Inflammation / Q000503:physiopathology; D044045:Lipoxins / Q000378:metabolism / Q000502:physiology*; D008084:Lipoxygenase / Q000378:metabolism; D051379:Mice; D009504:Neutrophils / Q000502:physiology; D044067:Receptors, Lipoxin / Q000378:metabolism; D014945:Wound Healing / Q000502:physiology*
D044045:Lipoxins; D044067:Receptors, Lipoxin; C040527:lipoxin A4; D008084:Lipoxygenase