Design, syntheses, and biological evaluations of squamostolide and its related analogs.
Squamostolide and its related analogs were designed and synthesized for biological evaluation. All these compounds were tested for growth inhibition activities against human tumor cell lines, in which one of the compounds showed the most potent cytotoxicity among these derivatives against a full panel of 60 human cancer cell lines. The same compound also showed G2/M phase arrest and a weak apoptotic effect during flow cytometric analysis.
Lee
Cheng-Lin
CL
Faculty of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan.
Lin
Chi-Fong
CF
Lin
Wan-Ru
WR
Wang
Kun-Sheng
KS
Chang
Ya-Her
YH
Lin
Shinne-Ren
SR
Wu
Yang-Chang
YC
Wu
Ming-Jung
MJ
D000480:Alkynes / Q000737:chemistry* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D016195:G2 Phase / Q000187:drug effects; D006801:Humans; D007783:Lactones / Q000737:chemistry* / Q000494:pharmacology*
D000480:Alkynes; D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; C506354:squamostolide