Dendritic cell expansion occurs in mesenteric lymph nodes of B10.BR mice infected with the murine nematode parasite Trichuris muris.
Dendritic cells (DCs) are a crucial element in the immune system and bridge innate and adaptive immunity. CD11c+ B220- DCs residing in Peyer's patches (PPs) have the ability to produce interleukin 10 (IL-10) and induce T helper (Th2) development. Evidence suggests that CD11c+ B220- DCs maintain the gut environment by suppressing Th1 responses with IL-10, resulting in a Th2-dominat gut environment. Th2 effectors are required for protection against the murine nematode parasite Trichuris muris, and thus CD11c+ B220- DCs may be involved in the induction of Th2 cells in T. muris infection. In the present study, the kinetics of CD11c+ B220- DCs were analyzed in mesenteric lymph nodes of B10.BR mice infected with the E-J isolate of T. muris, and the cellular expansion of CD11c+ B220- DCs was also observed. As well, the DC expansion was consistent with the occurrence of worm expulsion augmented by IL-4 and IL-13. The evidence here suggests the involvement of CD11c+ B220- DCs in protective Th2 responses to T. muris infection.
Koyama
Koichi
K
Department of Parasitology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara Kanagawa, 228-8555, Japan. koyama@kitasato-u.ac.jp
D000818:Animals; D049109:Cell Proliferation; D003713:Dendritic Cells / Q000276:immunology* / Q000473:pathology; D004195:Disease Models, Animal; D007411:Intestinal Diseases, Parasitic / Q000276:immunology* / Q000469:parasitology / Q000473:pathology; D008198:Lymph Nodes / Q000276:immunology* / Q000469:parasitology / Q000473:pathology; D008213:Lymphocyte Activation; D008297:Male; D008643:Mesentery; D051379:Mice; D008815:Mice, Inbred Strains; D010273:Parasitic Diseases, Animal / Q000276:immunology* / Q000469:parasitology / Q000473:pathology; D014257:Trichuriasis / Q000276:immunology* / Q000469:parasitology / Q000473:pathology; D014258:Trichuris / Q000502:physiology*