Serum hepatocyte growth factor concentration in obese women decreases after vertical banded gastroplasty.
BACKGROUND
Human obesity is associated with increased serum hepatocyte growth factor (HGF) concentration. This study examines whether reduced body fat mass after vertical banded gastroplasty (VBG) is associated with a decrease in serum HGF concentration.


METHODS
Serum HGF concentration and body weight, BMI, body fat mass, blood pressure, serum leptin, insulin, triacylglycerol, and cholesterol concentrations were studied in 10 obese women before and 1 year after VBG. 10 lean, healthy women were used as controls.


RESULTS
Obese women showed significantly higher serum HGF concentration than control (lean, healthy) subjects. The mean serum HGF concentration decreased significantly 1 year after VBG, but did not reach the value observed in lean women. After VBG, BMI, body fat mass and serum HGF had similar patterns of decrease. Moreover, serum HGF concentration was positively correlated with both BMI (r=0.6, P<0.01) and body fat mass (r=0.6, P<0.01). Before surgery in obese women, elevated blood pressure was observed, which decreased after VBG. Linear regression analysis between blood pressure and serum HGF concentration using all subjects, showed no correlation between either systolic blood pressure and serum HGF concentration (r=.15, P=NS) or between diastolic blood pressure and serum HGF concentration (r=0.1, P=NS). Insulin resistance index (HOMA score), serum leptin, insulin and triacylglycerol concentrations decreased 1 year after VBG. However, serum cholesterol concentration did not change significantly.


CONCLUSIONS
These results indicate that VBG results in a reduction in circulating HGF concentration. The reduced body fat mass may contribute in part to the decrease of serum HGF concentration after VBG. Because elevated serum HGF concentration may contribute to the progression of atherosclerosis, the decrease in serum HGF concentration after VBG may be beneficial for obese subjects.
Department of Biochemistry, Medical University of Gdansk, 80-211 Gdansk, Poland. juls@amg.gd.pl
Julian
J
Swierczynski
Justyna
J
Korczynska
Elzbieta
E
Goyke
Krystian
K
Adrych
Sylwia
S
Raczynska
Zbigniew
Z
Sledzinski
D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D000368:Aged; D005260:Female; D015391:Gastroplasty; D017228:Hepatocyte Growth Factor / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood* / Q000601:surgery; D011184:Postoperative Period
D017228:Hepatocyte Growth Factor