Craniopharyngiomas in children: Turkey experience.
OBJECTIVE
Craniopharyngiomas are the most frequently encountered suprasellar tumors in children. Although they have a benign histology, total resection without morbidity is very difficult.


METHODS
We aimed to review the results of pediatric craniopharyngioma patients treated in eight institutions in Turkey. There were 51 boys and 36 girls, ranging in age from 20 months to 18 years (mean 10.2 years). The most frequent symptom was headache, followed by visual disturbances. Hydrocephalus was seen most frequently in tumors greater than 4 cm in size (P=0.002). Hydrocephalus was associated with the decreased gross total resection (P=0.043). The recurrence (28%) was significantly higher in patients with subtotal and partial tumor removal (P=0.010). Bad outcome was significantly associated with tumor dimension (P=0.039); the greater the tumor dimension, the worse the outcome. Outcome was significantly better in patients older than 10 years (P=0.032). Gender, tumor type and location, presence of hydrocephalus and calcification, histological type of craniopharyngioma, and surgical approach did not have a significant effect on the outcome.


CONCLUSIONS
The treatment should be individualized and a multidisciplinary approach should be used. The goal of surgery should be gross total removal without mortality and with acceptable morbidity.
Erşahin
Yusuf
Y
Division of Pediatric Neurosurgery, Ege University Faculty of Medicine, 35100, Bornova, Izmir, Turkey. ersahin@med.ege.edu.tr
Yurtseven
Taskin
T
Ozgiray
Erkin
E
Mutluer
Saffet
S
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003397:Craniopharyngioma / Q000628:therapy*; D003399:Craniotomy / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007016:Hypophysectomy; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010910:Pituitary Irradiation / Q000379:methods; D010911:Pituitary Neoplasms / Q000628:therapy*; D016634:Radiosurgery; D012658:Sella Turcica / Q000601:surgery; D013100:Sphenoid Bone / Q000601:surgery; D015996:Survival Rate; D016896:Treatment Outcome; D014421:Turkey; D014786:Vision Disorders / Q000209:etiology