Effects of weight loss after biliopancreatic diversion on metabolism and cardiovascular profile.
BACKGROUND
Obesity is associated with increased prevalence of cardiovascular risk factors. Biliopancreatic diversion (BPD) for morbid obesity has been reported to produce anemia and malnutrition in short-term follow-up. The aim of our study was to analyze the effect of weight reduction on cardiovascular profile, renal function and nutritional status.


METHODS
35 morbidly obese patients underwent BPD. We analyzed the presence of cardiovascular risk factors, renal status, proteinuria and nutritional status before and 1 year after BPD.


RESULTS
Excess weight loss was 67% at 1 year after BPD. All cardiovascular risk factors (hypertension, diabetes, hyperlipidemia) improved during follow-up. We could not find any relevant signs of malnutrition in the patients. Microalbuminuria decreased and proteinuria disappeared after weight loss. We observed less urinary calcium and citrate excretion, with an increase in oxaluria, but these changes did not increase the incidence of renal stones.


CONCLUSIONS
BPD was followed by improved cardiovascular profile and a lower pro-inflammatory state. BPD did not produce significant malnutrition, anemia or renal stone disease.
Palomar
Rosa
R
Department of Nephrology, Hospital Marqués de Valdecilla, University of Cantabria, 39008 Santander, Spain. nefpfm@humv.es
Fernández-Fresnedo
Gema
G
Domínguez-Diez
Agustín
A
López-Deogracias
Maite
M
Olmedo
Francisco
F
Martín de Francisco
Angel L
AL
Sanz de Castro
Saturnino
S
Casado Martín
Fernando
F
Gómez-Fleitas
Manuel
M
Arias
Manuel
M
Fernández-Escalante
Carlos
C
D000328:Adult; D000740:Anemia / Q000453:epidemiology; D015904:Biliopancreatic Diversion; D001769:Blood / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000453:epidemiology; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D008660:Metabolism; D008875:Middle Aged; D009752:Nutritional Status; D009767:Obesity, Morbid / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery; D011184:Postoperative Period; D011507:Proteinuria / Q000453:epidemiology; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000453:epidemiology; D014545:Urinary Calculi / Q000453:epidemiology; D014556:Urine / Q000502:physiology; D015431:Weight Loss / Q000502:physiology*