CONREAL web server: identification and visualization of conserved transcription factor binding sites.
The use of orthologous sequences and phylogenetic footprinting approaches have become popular for the recognition of conserved and potentially functional sequences. Several algorithms have been developed for the identification of conserved transcription factor binding sites (TFBSs), which are characterized by their relatively short and degenerative recognition sequences. The CONREAL (conserved regulatory elements anchored alignment) web server provides a versatile interface to CONREAL-, LAGAN-, BLASTZ- and AVID-based predictions of conserved TFBSs in orthologous promoters. Comparative analysis using different algorithms can be started by keyword without any prior sequence retrieval. The interface is available at http://conreal.niob.knaw.nl.
Berezikov
Eugene
E
Hubrecht Laboratory, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands. berezikov@niob.knaw.nl
Guryev
Victor
V
Cuppen
Edwin
E
D000465:Algorithms; D001483:Base Sequence; D001665:Binding Sites; D003196:Computer Graphics; D017124:Conserved Sequence; D005786:Gene Expression Regulation; D020407:Internet; D011401:Promoter Regions, Genetic; D017422:Sequence Analysis, DNA / Q000379:methods*; D012984:Software; D014157:Transcription Factors / Q000378:metabolism*; D014584:User-Computer Interface
D014157:Transcription Factors