[The study on prescription and preparation of the sustained-released capsule of gegen isoflavones].
OBJECTIVE
To study the preparation of the sustained-released capsule of Gegen isoflavones (SRCGI) and choose the best prescription.


METHODS
EC and HPMC were used as sustained-released excipients. Uniform layout test was employed to design the formulation.


RESULTS
The best prescription release drug Q0.5h = 50% - 53%, to 100% at 12h and its dissolution behavior belongs to Higuchi Kinetics, Q = 17.19t1/2 +/- 38.75, r = 0.9959.


CONCLUSIONS
SRCGI obtained desirable effect of drug release.
Wei
Fenghuan
F
Southern Medical University, Guangzhou 510515.
Tian
Jingzhen
J
Wang
Yonggang
Y
D002214:Capsules; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D007887:Fabaceae / Q000737:chemistry*; D006358:Hot Temperature; D007529:Isoflavones / Q000032:analysis / Q000737:chemistry; D007700:Kinetics; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013678:Technology, Pharmaceutical / Q000379:methods*
D002214:Capsules; D003692:Delayed-Action Preparations; D007529:Isoflavones