Hectochlorin and morpholine derivatives from the Thai sea hare, Bursatella leachii.
Investigation of the EtOAc extract from the Thai sea hare, Bursatella leachii, resulted in the isolation of a potent stimulator of actin assembly, hectochlorin (1), and its new derivative, deacetylhectochlorin (2). Compound 2 exhibited more potent cytotoxicity than 1 against different human carcinoma cell lines. In addition, a new morpholine-2,5-dione analogue, syn-3-isopropyl-6-(4-methoxybenzyl)-4-methylmorpholine-2,5-dione (3), was co-isolated.
Bioactive Marine Natural Products Chemistry Research Unit (BMNCU), Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok, Thailand.
Suchada
S
Suntornchashwej
Narongsak
N
Chaichit
Minoru
M
Isobe
Khanit
K
Suwanborirux
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001048:Aplysia / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D009025:Morpholines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013785:Thailand; D013844:Thiazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D007783:Lactones; D009025:Morpholines; D013844:Thiazoles; C454807:hectochlorin