Functional magnetic resonance imaging in the treatment of epilepsy.
Although structural magnetic resonance imaging (MRI) is now in routine use in the evaluation and management of epilepsy, functional MRI (fMRI) has recently begun to provide a noninvasive and widely available modality for assessing regional brain function. fMRI studies of language and memory are able to show discrete areas of activation in cerebral cortex, are useful in lateralizing language and memory during presurgical evaluation, and are providing further insight into the processes underlying cerebral plasticity in the brains of epilepsy patients. The use of fMRI for localization of ictal phenomena may also contribute to the localization of seizure foci and to a better understanding of the pathophysiology of electrographic spikes. The combination of fMRI with electroencephalogram and other advanced structural imaging techniques may not only improve seizure localization, but may also contribute valuable information towards a better understanding of the pathophysiology of epilepsy and its consequences on brain development.
Department of Neurology, University of Pennsylvania, 3W Gates Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Joseph E
JE
Sullivan
John A
JA
Detre
D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000254:growth & development / Q000503:physiopathology*; D004569:Electroencephalography / Q000639:trends; D004827:Epilepsy / Q000175:diagnosis* / Q000503:physiopathology* / Q000628:therapy; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000639:trends*; D009473:Neuronal Plasticity / Q000502:physiology; D011237:Predictive Value of Tests; D011300:Preoperative Care / Q000639:trends