A rare case of solitary fibrous tumour of the pre-sacral space: morphological and immunohistochemical features.
A 28-year-old woman presented with abdominal pain. Ultrasonograhic examination showed a pre-sacral mass, with complex structure and well delimitated cystss with thick walls. The resected specimen was 7.5 x 6 x 4 cm in size, well circumscribed and yellow in colour, with cysstic change containing mucoid-like material. Histologically, the lesion was composed of spindle cells with high cellularity and rich vascularization with a haemangiopericytoma-like pattern. The diagnosis of solitary fibrous tumour (SFT) was made. The differential diagnosis for SFT of the pre-sacral spaace involves haemangiopericytoma, GIST, malignant mesothelioma, synovial sarcoma, leiomyomatous tumours and granulosa cell tumour. Immunohistochemical studies revealed reactivity for CD34, CD99 and Bcl-2, but no staining for desmin, inhibin, c-kit, EMA, CK, SMA, S-100 and CD31, confirming a diagnosis of SFT. Although SFT is usually associated with a favourable prognosis, close follow-up is recommended because of the limited information on its long-term behaviour.
Surgical Pathology and Gynaecology, Università Campus Bio-Medico, Roma, Italy.
E
E
Cristi
G
G
Perrone
C
C
Battista
P
P
Benedetti-Panici
C
C
Rabitti
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D005350:Fibroma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis; D006106:Granulosa Cell Tumor / Q000175:diagnosis; D006393:Hemangiopericytoma / Q000175:diagnosis; D006801:Humans; D007124:Immunoenzyme Techniques; D007889:Leiomyoma / Q000175:diagnosis; D008654:Mesothelioma / Q000175:diagnosis; D012186:Retroperitoneal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D012445:Sacrococcygeal Region; D013584:Sarcoma, Synovial / Q000175:diagnosis; D017154:Stromal Cells / Q000473:pathology; D016896:Treatment Outcome
D014408:Biomarkers, Tumor