[A comparative study of the renal damage produced after the extracorporeal shock wave lithotripsy according to the lithiasis location].
BACKGROUND
The Extracorporeal shock waves lithotripsy (ESWL) is fundamental in the treatment of lithiasis. However, there are evidences that it can produce renal damage. The objective of our study is to determine the degree of affectation of the glomerular and tubular function after ESWL, and the influence of the lithiasis location on the type of renal damage.


METHODS
A prospective longitudinal study was carried out in 14 patients with normal renal function subjected to ESWL. We determined the basal level, and the levels at the 24 hours, at the 4th and the 10th day post ESWL of: microalbuminuria (MA) (that values the glomerular function), and N-acetyl glucosamide (NAG) and alanine aminopeptidase (AAP), (that value the tubular function).


RESULTS
The basal levels of of MA, NAG and AAP didn't show significant differences in connection with the localization of the stones. A significant increase was observed of the three parameters only 24 hours post ESWL. No significant differences were observed between the variation of the microalbuminuria levels, AAP and NAG and the treatment in relation to the localization of the stones.


CONCLUSIONS
It exists a glomerular and tubular damage after ESWL. This damage is not related with the pelvic or calicial location of the stones. In patient with previous normal renal function, the renal damage recovers at the 4th day post ESWL.
Servicio de Urología, Hospital Central de la Defensa, Madrid.
Ma J
MJ
Cancho Gil
R
R
Díz Rodríguez
M
M
Vírseda Chamorro
C
C
Alpuente Román
J A
JA
Cabrera Cabrera
P
P
Paños Lozano
D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000209:etiology*; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology; D007677:Kidney Function Tests; D008096:Lithotripsy / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014545:Urinary Calculi / Q000628:therapy*