Identification of a novel HLA-DRB1 allele (HLA-DRB1*111902*).
In this paper, we report a new HLA-DRB1 allele identified in a male acute myeloid leukaemia Chinese patient. This sample was initially typed as DRB1*11XX using commercial polymerase chain reaction-sequence-specific primers kit. When it was typed using a chip-based sequence-specific oligonucleotide technique, a novel hybridization pattern that does not match any known alleles was observed. Through sequencing, we have identified this allele as a new HLA-DRB1 allele, which was later named HLA-DRB1*111902 by the WHO Nomenclature Committee. The sequence of this new allele differs from DRB1*111901 by one nucleotide (from G to C) at 203nt of exon 2 but does not cause any amino acid substitution.
Peking University Institute of Hematology, Beijing, P. R. China.
D
D
Li
H F
HF
Gao
X
X
Liu
D
D
Jiang
Z
Z
Li
Y H
YH
Liu
Y Z
YZ
Jiang
L
L
Li
G X
GX
Lan
C Z
CZ
Zhao
T
T
Guo
B
B
Cai
D
D
Wang
G Y
GY
Sun
D
D
Zhang
D P
DP
Lu
D000483:Alleles; D001483:Base Sequence; D002681:China; D005091:Exons; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D012689:Sequence Homology, Nucleic Acid
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C503976:HLA-DRB1*11:19:02 antigen