Approaches to the study of inflammatory gene haplotypes and susceptibility to cardiac, vascular and pulmonary diseases.
Haplotype association methods are increasingly being used in the study of complex diseases to better understand and correlate genetic polymorphisms with cardiovascular and pulmonary disease phenotypes and drug responses. Understanding of the human genome is rapidly expanding; how this knowledge is impacting the determination of haplotypes and how they can be utilized in the study of complex diseases is reviewed. Applied and methodological fields are discussed and examples of how haplotypes are used to study complex diseases in this modern era are provided.
The James Hogg-iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul's Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada. ddaley@mrl.ubc.ca
Denise
D
Daley
Kelly
K
Burkett
D002318:Cardiovascular Diseases / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D007249:Inflammation / Q000235:genetics; D008171:Lung Diseases / Q000235:genetics*