An evaluation of the reinforcing effects of memantine in cocaine-dependent humans.
The purpose of this double-blind, outpatient study was to evaluate the reinforcing and subjective effects of the uncompetitive N-methyl-d-aspartate (NMDA) antagonist memantine in cocaine-dependent humans. Eight participants (two females, six males) completed this study which consisted of three blocks of seven sessions; each block tested a different dose of memantine. During the first two sessions of each block, participants "sampled" the memantine capsule (10, 20, or 30 mg) and the placebo capsule that were available for the next five sessions. During the five subsequent sessions, participants had an opportunity to self-administer either the active or placebo capsule. Memantine was not reinforcing and subjective-effects ratings were not altered as a function of dose. Results suggest that these doses of memantine do not have abuse liability in cocaine-dependent individuals.
College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA. skv2001@columbia.edu
Suzanne K
SK
Vosburg
Carl L
CL
Hart
Margaret
M
Haney
Richard W
RW
Foltin
D000328:Adult; D000553:Ambulatory Care; D003042:Cocaine / Q000652:urine; D019970:Cocaine-Related Disorders / Q000188:drug therapy* / Q000652:urine; D015259:Dopamine Agents / Q000627:therapeutic use*; D018765:Dopamine Uptake Inhibitors / Q000652:urine; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008559:Memantine / Q000627:therapeutic use*; D016202:N-Methylaspartate / Q000037:antagonists & inhibitors*; D012054:Reinforcement, Psychology
D015259:Dopamine Agents; D018765:Dopamine Uptake Inhibitors; D016202:N-Methylaspartate; D003042:Cocaine; D008559:Memantine