B cell tolerance: lessons from transplantation.
Given the ability of the B cell compartment to acquire tolerance to self we cannot explain why spontaneous humoral tolerance does not arise following transplantation. Here we review the fundamental mechanisms of B cell tolerance that operate in development and direct the reader to possible mechanisms that may explain how B cell tolerance fails to develop following transplantation.
Mayo Clinic College of Medicine, 200 First Street SW, Medical Sciences 2-113, Rochester, MN 55905, USA. Cascalho.marilia@mayo.edu
Marilia
M
Cascalho
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D007108:Immune Tolerance; D014181:Transplantation Immunology; D014184:Transplantation, Homologous