A facile synthesis of [(11)C]acetylene.
Acetylene is a versatile synthon organic chemistry. The complexity and difficulty of synthesis of [(11)C]acetylene has limited its use as a labeling intermediate for PET radiotracers. A new method for production of [(11)C]acetylene has been developed in our laboratory that simplifies the synthesis procedure allowing for easy automation and implementation. The technique is a modification of Madsen et al. (1981, Phys. Med. Biol. 26(5), 875) that utilized carbon dioxide ((11)C) and barium. First [(11/12)C]CO(2) was trapped at room temperature on barium within a quartz reaction tube, then heated to 900 degrees C under hydrogen flow to release [(11)C]acetylene. Hydrogen gas is apparently oxidized to form water vapor which reacts immediately with the formed carbide to liberate acetylene. Radiochemical yields of 31.4--75.4% and specific activities of 0.11-- 161 mCi/micromol have been obtained with radiochemical purities greater than 99%. This technique provides a new, efficient and very practical synthesis of [(11)C]acetylene that can be utilized as synthon for novel PET radiopharmaceuticals.
Department of Radiology, Indiana University School of Medicine, 1345 W. 16th Street L-3 R# 204, Indianapolis, IN 46202, USA.
Rachid
R
Nazih
Jeremy P
JP
Blauser
Bruce H
BH
Mock
Timothy R
TR
Degrado
D000114:Acetylene / Q000138:chemical synthesis*; D002250:Carbon Radioisotopes / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D000114:Acetylene