Association of DNA polymorphisms in the synaptic vesicular amine transporter gene (SLC18A2) with alcohol and nicotine dependence.
The brain synaptic vesicular amine transporter SLCA18A2 is a key component for the uptake of monoamines like dopamine or serotonin into vesicles. We have analyzed seven DNA polymorphisms located in the genomic region of SLC18A2 for association with alcohol- and nicotine dependence, using a family-based design. Our sample comprised 131 families with alcohol-dependent offspring and 96 families with at least one nicotine-dependent offspring. For the alcohol-dependent sample, we found statistical significant association for two single markers (rs363387, P=0.03; rs363333, P=0.0066) as well as for several haplotypes (minimal P=0.0038). When the sample with alcohol dependence was stratified according to gender, we observed increased association for the male subgroup (rs363387, P=0.0011). None of the markers showed association in the sample of families with nicotine dependence. However, analysis of a combined sample of alcohol and nicotine-dependent families resulted in single markers as well as several haplotypes showing statistical significant association with substance dependence (minimal P=0.0044). We conclude that DNA polymorphisms located in SLC18A2 might contribute to the development of substance dependence.
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, WA, Australia. sschwab@cyllene.uwa.edu.au
Sibylle G
SG
Schwab
Petra E
PE
Franke
Barbara
B
Hoefgen
Vera
V
Guttenthaler
Dirk
D
Lichtermann
Matyas
M
Trixler
Michael
M
Knapp
Wolfgang
W
Maier
Dieter B
DB
Wildenauer
D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology; D004247:DNA / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D012727:Sex Characteristics; D014029:Tobacco Use Disorder / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology; D050493:Vesicular Monoamine Transport Proteins / Q000235:genetics*
D005819:Genetic Markers; C493452:SLC18A2 protein, human; D050493:Vesicular Monoamine Transport Proteins; D004247:DNA