[Clinical significance of PML/RARalpha isoforms in adult patients with acute promyelocytic leukemia].
To evaluate the relation of PML/RARalpha isoforms in adult APL patients to clinical therapy and prognosis, the picture of blood and bone marrow aspirates for 71 APL patients treated by induction therapy were peridically examined and the different transcripts of PML/RARalpha were assayed by nested RT-PCR. The results showed that the median WBC count (x 10(9)/L) in the patients with the short (S) and variable (V) isoform were significantly higher than that in long (L) isoform. So, the serious bleeding complications early occurred. Relapse risk for patients with S and variable isoforms were higher than that with L isoform. In conclusion, PML/RARalpha isoforms in patients with APL may be the independent prognostic factor.
Sun
Ai-Ning
AN
Department of Hematology, The First Affiliated Hospital of Suzhou University, Jiangsu Institute of Hematology, Suzhou 215006, China. ainingsun@hotmail.com
Zhou
Hai-Xia
HX
Wu
De-Pei
DP
Wang
Wei
W
Jin
Zheng-Ming
ZM
Qiu
Hui-Ying
HY
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000097:blood / Q000235:genetics* / Q000473:pathology; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D011379:Prognosis; D020033:Protein Isoforms / Q000235:genetics; D018168:Receptors, Retinoic Acid / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D015514:Oncogene Proteins, Fusion; D020033:Protein Isoforms; D018168:Receptors, Retinoic Acid; C093476:promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein