Long latency evoked potential database for clinical applications: justification and examples.
We summarize our experience with the clinical utility of long latency evoked potential (EP) data in clinical QEEG studies. In contrast to common wisdom, such EP data are consistent across appropriately chosen age groups. In a healthy adult population, EP data correlate consistently with independently collected psychological variables. In our pediatric referral population, EP data are of greatest and most unique value in the learning disabilities but also augment detection of abnormality in epilepsy and behavioral abnormality. Selection of subjects for a clinical database on the basis of examined medical, neurological and behavioral health, forms adequately consistent groupings for clinical utility. The use of the Z-SPM is essential for detection of EP abnormality. A minimum of three replications within a clinical study protects against chance/false positives. Also, the true data dimensionality within EP data sets is far less than the total number of variables typically collected.
Department of Neurology, Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA. fhd@sover.net
Frank H
FH
Duffy
D000293:Adolescent; D000465:Algorithms; D002648:Child; D002675:Child, Preschool; D016208:Databases, Factual; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004569:Electroencephalography / Q000379:methods*; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D008297:Male; D016347:Medical Records Systems, Computerized; D008875:Middle Aged; D009422:Nervous System Diseases / Q000145:classification / Q000175:diagnosis*; D011930:Reaction Time; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D014584:User-Computer Interface