Humoral immune responses of lung cancer patients against tumor antigen NY-ESO-1.
The cancer-associated antigen NY-ESO-1 is expressed in a number of malignancies of different histological type. Patients with NY-ESO-1 expressing tumors have been shown to bear circulating autoantibodies against this antigen. In this study, we have assessed the NY-ESO-I autoantibody response in patients with lung cancer by a serum ELISA. Using a serum dilution of 1:400 we detected seroreactivity in 35 of 175 (20%) of patients. Incidence of autoantibodies was significantly higher in patients suffering from non small cell lung cancer (NSCLC, 23%) as compared to those with small cell lung cancer (SCLC, 9%). In the NSCLC group, NY-ESO-I antibody was significantly more frequent in patients with undifferentiated tumors (40%) as compared to patients with either adenocarcinoma or squamous cell carcinoma (15 and 29%). Our observations indicate that induction of NY-ESO-I autoantibodies depends on the histological subtype within a given tumor entity.
Department of Internal Medicine, Johannes Gutenberg University, Obere Zahlbacherstr.63, D-55131 Mainz, Germany. tureci@mail.uni-mainz.de
Ozlem
O
Türeci
Ulrich
U
Mack
Ulrich
U
Luxemburger
Helma
H
Heinen
Frank
F
Krummenauer
Martina
M
Sester
Urban
U
Sester
Gerhard W
GW
Sybrecht
Ugur
U
Sahin
D000230:Adenocarcinoma / Q000097:blood* / Q000276:immunology / Q000473:pathology; D000368:Aged; D000912:Antibodies, Neoplasm / Q000097:blood*; D000951:Antigens, Neoplasm / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood* / Q000276:immunology / Q000473:pathology; D018288:Carcinoma, Small Cell / Q000097:blood* / Q000276:immunology / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000276:immunology / Q000473:pathology; D002454:Cell Differentiation; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000276:immunology / Q000473:pathology; D008297:Male; D008565:Membrane Proteins / Q000276:immunology*; D008875:Middle Aged
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D001323:Autoantibodies; C104948:CTAG1B protein, human; D008565:Membrane Proteins