Emerging drugs for neuropathic pain.
Although there are many analgesics on the market for the treatment of nociceptive pain, there are none with FDA approval for the treatment of neuropathic pain. With a better understanding of the anatomy and physiology of pain, there is a significant effort in developing new drugs that interact specifically with pain pathways. This higher drug specificity is likely to result in drugs that are more efficacious with fewer side effects. This has led to the development of many drugs for the treatment of neuropathic pain. These drugs are divided into the following therapeutic classes: 1) N-methyl-D-aspartate (NMDA) receptor antagonists, 2) ion channel antagonists, 3) alpha2-agonists, 4) nicotinic receptor agonists, 5) prostaglandin receptor antagonists, 6) adenosine agonists and adenosine kinase inhibitors, 7) neuropeptide antagonists, and 8) prosaposins. The results of preclinical and clinical trials are promising for these new agents. Whether these agents will be efficacious as single agents is yet to be determined; however, preliminary results show that combination therapy may be more beneficial with fewer side effects.
Wallace
M S
MS
University of California, San Diego, Center for Pain and Palliative Medicine, Department of Anesthesiology, 9500 Gilman Drive #0924, La Jolla, CA 92093-0924, USA. mswallace@ucsd.edu