The effect of exposure time on maximum acceptable dose for avoidance of ultraviolet radiation-induced cataract.
The effect of exposure time on maximum acceptable dose (MAD) for avoidance of ultraviolet radiation B (UVRB)-induced cataract was investigated. Sprague-Dawley rats were divided into 5 exposure time groups: 7.5, 15, 30, 60, and 120 min. Each exposure time group was divided into 5 dose subgroups: 0, 1, 2, 4, and 8 kJ/m2. The rats were unilaterally exposed to UVR around 300 nm. One week after the exposure, macroscopic structure was recorded and lens forward light scattering was measured. MAD for avoidance of UVRB-induced cataract was estimated based on the dose-response function. MAD for avoidance of UVRB-induced cataract for 7.5, 15, 30, 60, and 120 min exposures was estimated to be 2.0, 1.4, 1.9, 1.8 and 2.2 kJ/m2, respectively. In the exposure time domain 7.5-120 min, MAD for avoidance of UVRB-induced cataract depends on exposure time.
Department of Clinical Neuroscience, Karolinska Institutet, St. Erik's Eye Hospital, Stockholm, Sweden. xiuqin.dong@ste.ki.se
Xiuqin
X
Dong
Per G
PG
Söderberg
Marcelo
M
Ayala
Stefan
S
Löfgren
D000818:Animals; D002386:Cataract / Q000209:etiology / Q000517:prevention & control*; D004307:Dose-Response Relationship, Radiation; D007908:Lens, Crystalline / Q000528:radiation effects*; D008027:Light; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000209:etiology / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012542:Scattering, Radiation; D013997:Time Factors; D014466:Ultraviolet Rays / Q000009:adverse effects*