[The mechanism of parathyroid hormone action].
PTH is one of the promising bone forming agents. However, its mechanism for bone formation remains unknown. The putative accumulating hypothesis about the mechanism is the following;the involvement of local bone forming growth factors, such as insulin-like growth factor-I, anti-apoptotic actions through Runx2 and Smad3 etc, the transcriptional regulators, such as AP-1 and CREB. The research for the action of PTH would bring the development of effective PTH treatment and the investment of agents, which are more effective to increase bone formation.
Kaji
Hiroshi
H
Division of Endocrinology/Metabolism, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine.
Sugimoto
Toshitsugu
T
D006801:Humans; D010281:Parathyroid Hormone / Q000494:pharmacology / Q000502:physiology*
D010281:Parathyroid Hormone