Is tissue-plasminogen activator gene polymorphism a risk factor for venous thromboembolism in every population?
BACKGROUND
Tissue-plasminogen activator is a key protein of fibrinolytic system. In recent years the relation between t-PA, its genetic polymorphisms and arterial or venous thrombosis were investigated in different populations. The aim of this study is to investigate the role of t-PA gene polymorphism in Turkish venous thromboembolism (VTE) patients.


METHODS
A case-control study was performed. We investigated the t-PA insertion/deletion (I/D) polymorphism in 93 VTE patients and 146 controls without VTE. Recurrent cases and documented risk factors for PTE were recorded.


RESULTS
Cases and controls did not differ with respect to the different t-PA genotypes. The prevalence of I allele was 44.1%, 44.5% in cases and controls respectively (OR = 0.95, 95% CI: 0.78-1.24, p > 0.05). Different t-PA genotypes had no effect on recurrent disease. No gender difference was observed with respect to the different t-PA genotypes. There was no significant difference for genotype frequency between PTE patients with documented risk factors and unprovoked cases.


CONCLUSIONS
In conclusion there was no association between t-PA genotype and VTE in this group of Turkish population. It was also found that genotype frequencies for t-PA in both VTE and control subjects seems different from those reported from western part of the world. ABBREVIATED ABSTRACT: The aim of this study is to investigate the role of t-PA gene polymorphism in Turkish VTE patients. We investigated 93 VTE patients and 146 controls without VTE. Cases and controls did not differ with respect to the different t-PA genotypes. The prevalence of I allele was 44.1%, 44.5% in cases and controls respectively (OR = 0.95, 95% CI: 0.78-1.24, p > 0.05). Different t-PA genotypes had no effect on recurrent disease. No gender difference was observed with respect to the different t-PA genotypes. There was no significant difference for genotype frequency between PTE patients with documented risk factors and unprovoked cases. In conclusion there was no association between t-PA genotype and VTE in this group of Turkish population. It was also found that genotype frequencies for t-PA in both VTE and control subjects seems different from those reported from western part of the world.
Department of Pulmonary Medicine, Gazi University School of Medicine, Turan Gunes Bulvari 92/2, Cankaya 06550, Ankara, Turkey. ipek@gazi.edu.tr
I Kivilcim
IK
Oguzulgen
Numan
N
Ekim
Ferda Oner
FO
Erkekol
Buket
B
Altinok
Nejat
N
Akar
D001483:Base Sequence; D016022:Case-Control Studies; D017931:DNA Primers; D005260:Female; D005342:Fibrinolysis / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012016:Reference Values; D012307:Risk Factors; D013923:Thromboembolism / Q000453:epidemiology / Q000235:genetics*; D010959:Tissue Plasminogen Activator / Q000235:genetics*; D014421:Turkey; D020246:Venous Thrombosis / Q000235:genetics*
D017931:DNA Primers; D010959:Tissue Plasminogen Activator