[Protected mercaptoalkylpyrimidinones: synthesis and test for immunostimulating activity].
Protected mercaptoalkylpyrimidinones: synthesis and test for immunostimulating activity 3-Hydroxyalkyl-pyrimidine 1 reacts with phosphoroxychloride and thioglycolic acid or thiourea to yield pyrimidin-3-ylalkylthioacetic acids 3 or pyrimidin-3-ylalkylthiouroniumsalts 5 respectively. Some of the pyrimidines 3 and 5 showed immunomodulatory activity.
Fakultät für Biowissenschaften der Universität Leipzig, Germany.
D
D
Briel
K
K
Drössler
A
A
Rybak
M
M
Holzer
B
B
Dobner
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D006168:Guinea Pigs; D007111:Immunity, Cellular / Q000187:drug effects; D007202:Indicators and Reagents; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology*; D012882:Skin Tests; D013440:Sulfides / Q000138:chemical synthesis* / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D007202:Indicators and Reagents; D011744:Pyrimidinones; D013440:Sulfides