Early loss of two renal grafts obtained from the same donor: role of ecstasy?
Early loss of renal grafts is generally caused by vascular or immunologic complications. We describe two patients who received a kidney transplant from the same donor and lost their grafts during the first posttransplant week. Both cases presented necrotizing graft vasculopathy without inflammatory element. The donor was a 21-year-old woman who regularly used "ecstasy" over a 2-year period. After an extensive work-up to investigate the potential causes of graft loss, we considered the possibility of ecstasy being the cause of these two renal-graft losses.
Department of Nephrology and Renal Transplantation, Caen University Hospital, Caen, France. huraultdeligny-b@chu-caen.fr
Bruno
B
Hurault de Ligny
Wael
W
El Haggan
François
F
Comoz
Thierry
T
Lobbedez
Myriam
M
Pujo
Anne Marie
AM
Griveau
Philippe
P
Bottet
Henri
H
Bensadoun
Jean Philippe
JP
Ryckelynck
D000328:Adult; D005922:Glomerulonephritis, IGA / Q000150:complications; D006213:Hallucinogens / Q000633:toxicity*; D006650:Histocompatibility Testing; D006801:Humans; D007238:Infarction / Q000473:pathology; D007668:Kidney / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery; D016030:Kidney Transplantation / Q000473:pathology*; D008297:Male; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000633:toxicity*; D012079:Renal Circulation; D013927:Thrombosis / Q000473:pathology; D014019:Tissue Donors; D017211:Treatment Failure
D006213:Hallucinogens; D018817:N-Methyl-3,4-methylenedioxyamphetamine