Ultrahigh density microarrays of solid samples.
We present a sectioning and bonding technology to make ultrahigh density microarrays of solid samples, cutting edge matrix assembly (CEMA). Maximized array density is achieved by a scaffold-free, self-supporting construction with rectangular array features that are incrementally scalable. This platform technology facilitates arrays of >10,000 tissue features on a standard glass slide, inclusion of unique sample identifiers for improved manual or automated tracking, and oriented arraying of stratified or polarized samples.
Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University Medical Center, NRB E504, 3970 Reservoir Rd. NW, Washington, DC 20057-1469, USA.
Matthew J
MJ
LeBaron
Heidi R
HR
Crismon
Fransiscus E
FE
Utama
Lynn M
LM
Neilson
Ahmed S
AS
Sultan
Kevin J
KJ
Johnson
Eva C
EC
Andersson
Hallgeir
H
Rui
D004867:Equipment Design; D019544:Equipment Failure Analysis; D046228:Microarray Analysis / Q000295:instrumentation / Q000379:methods*; D008867:Microtomy / Q000295:instrumentation / Q000379:methods*; D013048:Specimen Handling / Q000295:instrumentation / Q000379:methods*; D046509:Tissue Culture Techniques / Q000295:instrumentation / Q000379:methods*; D016610:Tissue Embedding / Q000295:instrumentation / Q000379:methods*