[The role of Chlamydia pneumoniae in the pathogenesis of abdominal aortic aneurysm].
Abdominal aortic aneurysm is a disease with complicated pathogenesis. The known risk factors do not explain fully the mechanism of pathological change formation, and their modification does not stop but only can retard the illness progression. Since an exacerbated inflammation has been detected in the aneurysms wall, the hypothesis should be taken under consideration that some role in the disease development may play microorganisms. Most attention has been concentrated on Chlamydia pneumoniae, bacteria which causes respiratory infection and which participation in pathogenesis of atherosclerosis is a subject of a discussion that has been carried for years now. Since 1996 there has been presented an increased number of proofs (serological studies, in situ detection, in vitro and animal-model studies), that the infection of C. pneumoniae is not neutral for the process of aneurysm formation. Especially important is the successful attempt of bacterial culture from aneurysmal tissue. However, there are still debatable issues, which make impossible to give an ultimate answer to the question about the relationship between C. pneumoniae and abdominal aortic aneurysm.
Witkiewicz
Wojciech
W
Oddział Chirurgii Ogólnej i Naczyniowej Wojewódzkiego Szpitala Specjalistycznego we Wrocławiu.
Gnus
Jan Janusz
JJ
Drohomirecka
Anna
A
D017544:Aortic Aneurysm, Abdominal / Q000382:microbiology*; D023521:Chlamydophila Infections / Q000150:complications* / Q000382:microbiology; D016993:Chlamydophila pneumoniae / Q000302:isolation & purification*; D002986:Clinical Trials as Topic; D006801:Humans