Pseudopyronines A and B, alpha-pyrones produced by a marine Pseudomonas sp. F92S91, and evidence for the conversion of 4-hydroxy-alpha-pyrone to 3-furanone.
In our search for inhibitors of bacterial fatty acid biosynthesis, two new alpha-pyrones, pseudopyronines A (1) and B (2), were isolated from a marine Pseudomonas sp. F92S91. The naturally occurring alpha-pyrones appeared to be unstable, evidenced by the conversion of pseudopyronine B into an oxidation product, 3-furanone (3). Structural elucidations were made by spectroscopic analyses including 2D-NMR data.
Chemical and Screening Sciences, Wyeth Research, Pearl River, New York 10965, USA. kongf@wyeth.com
Fangming
F
Kong
Maya P
MP
Singh
Guy T
GT
Carter
D005663:Furans / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011549:Pseudomonas / Q000737:chemistry* / Q000378:metabolism; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D005663:Furans; D011753:Pyrones; C502674:pseudopyronine A; C502676:pseudopyronine B