Observations on the Vietnam Palo Alto strain of Plasmodium vivax in two species of Aotus monkeys.
Thirty-three splenectomized Aotus lemurinus griseimembra monkeys with no previous experience with malaria were infected with the Vietnam Palo Alto strain of Plasmodium vivax. The median maximum parasite count was 280,000/microl. Nine splenectomized monkeys with previous infection with Plasmodium falciparum had median maximum parasite counts of 120,000/microl. Splenectomized Aotus nancymai monkeys supported infections at a lower level. Transmission via the bites of Anopheles dirus mosquitoes was obtained in a splenectomized A. lemurinus griseimembra, with a prepatent period of 31 days. It is estimated that between 1.5 x 10(8) and 1.6 x 10(9) parasites can be removed from an infected animal for molecular or diagnostic antigenic studies.
Collins
William E
WE
Division of Parasitic Disease and Animal Resources Branch, National Center for Infectious Disease, Atlanta, Georgia 30341, USA. wec1@cdc.gov
Sullivan
JoAnn S
JS
Galland
G Gale
GG
Williams
Allison
A
Nace
Douglas
D
Williams
Tyrone
T
Barnwell
John W
JW
D000818:Animals; D000852:Anopheles / Q000469:parasitology; D016645:Aotidae / Q000276:immunology / Q000469:parasitology*; D004195:Disease Models, Animal; D007303:Insect Vectors / Q000469:parasitology; D016780:Malaria, Vivax / Q000276:immunology / Q000469:parasitology / Q000635:transmission*; D010966:Plasmodium vivax / Q000145:classification / Q000276:immunology / Q000502:physiology*; D013156:Splenectomy