[Apoptosis--molecular basis in pathogenesis of selected chronic inflammatory and neoplastic diseases].
Apoptosis is a physiological programmed cell death. The molecular regulation of this process is very complex and still unknown. Disregulation in the mechanisms controlling apoptosis are thought to be the cause of many diseases. Mutations in gene p53 lead to carcinous transformation, high expression of receptor Fas increases the cell elimination in chronic inflammatory processes. Wrong balance between apoptosis regulatory proteins Bcl-2/Bax is the reason for low mortality, radioresistance and chemoresistance. Studies of mechanisms controlling interactions between apoptotic proteins will let us find new diagnostic and therapeutic methods.
Katedra i Klinika Neurochirurgii i Neurotraumatologii Akademii Medycznej w Poznaniu. mkopa6@wp.pl
Bartlomiej
B
Kopaczewski
Magda
M
Kopaczewska
Stanisław
S
Nowak
D017209:Apoptosis; D001932:Brain Neoplasms / Q000378:metabolism*; D002908:Chronic Disease; D004066:Digestive System Diseases / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D051028:bcl-2-Associated X Protein; D019014:fas Receptor / Q000378:metabolism
C494826:BAX protein, human; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53; D051028:bcl-2-Associated X Protein; D019014:fas Receptor