[Primitive neuroectodermal tumor arising 8 years after chemotherapy and radiotherapy for acute lymphoblastic leukemia: case report].
We report a case of primitive neuroectodermal tumor (PNET) arising 8 years after chemotherapy and radiotherapy for acute lymphoblastic leukemia. A 15-year-old boy with a history of acute lymphoblastic leukemia, at the age of 7, underwent chemotherapy and 14Gy of radiotherapy to the whole brain. He was admitted to our department due to the development of aphasia, right hemiparesis and generalized convulsive seizure. MRI showed an irregularly enhanced mass in the left frontal lobe. A gross total removal of the tumor was performed and histological examination showed it to be PNET. Postoperatively, the patient underwent 20Gy of radiotherapy to the whole brain and 42Gy of local radiotherapy. Follow-up MRI showed no evidence of recurrent tumor 4 months after the radiotherapy. This tumor was thought to be a secondary brain tumor arising in this survivor of childhood acute lymphoblastic leukemia and it is a rare complication of successful leukemia treatment.
Department of Neurosurgery, Fukui Prefectural Hospital, 2-8-1 Yotsui, Fukui-shi, Fukui 910 - 0846, Japan.
Yuya
Y
Yoshida
Yasuo
Y
Toma
Masayuki
M
Arai
Ryo
R
Higashi
Kengo
K
Kashihara
Yasuharu
Y
Kaizaki
D000293:Adolescent; D001932:Brain Neoplasms / Q000209:etiology / Q000532:radiotherapy / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D006801:Humans; D008297:Male; D016609:Neoplasms, Second Primary; D018242:Neuroectodermal Tumors, Primitive / Q000209:etiology / Q000532:radiotherapy / Q000601:surgery*; D019635:Neurosurgical Procedures; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D011879:Radiotherapy Dosage