Y-chromosome STR haplotype diversity in three ethnic populations in Singapore.
In this study, 12 Y-STR loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385a/b, DYS437, DYS438 and DYS439) were genotyped in the three major ethnic populations in Singapore, namely the Chinese, Malay and Indian. Allele frequency distribution, locus diversity, haplotype diversity and discrimination capacity were estimated. Analysis of molecular variance between the three ethnic populations indicated that 87.71% of the haplotypic variation is found within population and 12.29% is between populations (Fixation Index FST=0.123, p=0.000). Population pairwise comparisons showed significant Phist values between all population pairs, with the lowest (RST=0.05) for Chinese-Malay and the highest (RST=0.19) for Chinese-Indian.
Defence Medical & Environmental Research Institute, DSO National Laboratories, 27 Medical Drive #09-01, Singapore 117510, Singapore.
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RY
Yong
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LK
Lee
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Yap
D044466:Asian People / Q000235:genetics; D041322:Chromosomes, Human, Y / Q000235:genetics*; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D012846:Singapore; D020080:Tandem Repeat Sequences / Q000235:genetics*