[Influence of wen-yang herbs on hemodynamics in liver fibrotic rats].
OBJECTIVE
To observe the influence of wen-yang herbs on the hemodynamics in liver fibrotic rats.


METHODS
Wistar rats with liver fibrosis, induced by carbon tetrachloride and alcohol, were randomly divided into a treatment group and a control group. The treatment group was administered wen-yang herbs and the control group saline. At the end of the experiment, the hemodynamic markers of the liver and the mesentery, the liver function and hydroxyproline content of liver tissues between the two groups were compared. Blood volume of the livers and hydroxyproline content of liver tissues were also determined.


RESULTS
Blood volume of the liver and mesentery (P < 0.01) and blood flow velocity of small vein of mesentery (P < 0.05) of the treatment group were distinctly higher than the control group. The hydroxyproline content (P < 0.01) of the treatment group was remarkably reduced and liver function was improved.


CONCLUSIONS
Wen-yang herbs can activate microcirculation of the liver and mesentery, decrease the deposit of collagen in the liver and improve liver function.
Department of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China.
Li-chun
LC
Wang
Lian-san
LS
Zhao
Hong
H
Tang
Li
L
Liu
Cong
C
Liu
Bing-jun
BJ
Lei
D000818:Animals; D001775:Blood Circulation / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D008106:Liver Cirrhosis, Experimental / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008517:Phytotherapy; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal