Capsazepine, a vanilloid receptor antagonist, inhibits allergen-induced tracheal contraction.
To investigate the possible role of the vanilloid receptor-1 (TRPV1) in allergic airway responses, the effect of the specific TRPV1 receptor antagonist capsazepine was examined. Capsazepine significantly decreased the ovalbumin-induced contraction of isolated tracheal rings from ovalbumin-sensitized guinea pigs. This is the first report directly showing the involvement of the TRPV1 in experimental allergic airway responses.
van den Worm
Edwin
E
Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO BOX 80082, 3508 TB Utrecht, The Netherlands.
de Vries
Annick
A
Nijkamp
Frans P
FP
Engels
Ferdi
F
D000485:Allergens / Q000494:pharmacology*; D000818:Animals; D002211:Capsaicin / Q000031:analogs & derivatives* / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D010047:Ovalbumin / Q000494:pharmacology; D011955:Receptors, Drug / Q000037:antagonists & inhibitors* / Q000502:physiology; D014132:Trachea / Q000187:drug effects* / Q000502:physiology
D000485:Allergens; D011955:Receptors, Drug; D010047:Ovalbumin; C071423:capsazepine; D002211:Capsaicin