Protein-bound advanced glycation endproducts (AGEs) as bioactive amino acid derivatives in foods.
The Maillard reaction or nonenzymatic browning is of outstanding importance for the formation of flavour and colour of heated foods. Corresponding reactions, also referred to as "glycation", are known from biological systems, where the formation of advanced glycation endproducts (AGEs) shall play an important pathophysiological role in diabetes and uremia. In this review, pathways leading to the formation of individual protein-bound lysine and arginine derivatives in foods are described and nutritional consequences resulting from this posttranslational modifications of food proteins are discussed.
Institute of Food Chemistry, Technical University of Dresden, Germany. Thomas.Henle@chemie.tu-dresden.de
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D000596:Amino Acids / Q000737:chemistry*; D000818:Animals; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D005502:Food; D017127:Glycation End Products, Advanced / Q000737:chemistry*; D006031:Glycosylation; D006801:Humans; D015416:Maillard Reaction; D008969:Molecular Sequence Data; D015394:Molecular Structure; D011506:Proteins / Q000737:chemistry*
D000596:Amino Acids; D017127:Glycation End Products, Advanced; D011506:Proteins