Design, synthesis, and biological characterization of potential antiatherogenic nitric oxide releasing tocopherol analogs.
Synthesis and biological characterization of a series of alpha-tocopherol analogs with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties, and antiplatelet activity. They were also capable of preventing LDL oxidation.
López
Gloria V
GV
Departamento de Química Orgánica, Facultad de Ciencias-Facultad de Química, Universidad de la República, Montevideo, Uruguay.
Batthyány
Carlos
C
Blanco
Fabiana
F
Botti
Horacio
H
Trostchansky
Andrés
A
Migliaro
Eduardo
E
Radi
Rafael
R
González
Mercedes
M
Cerecetto
Hugo
H
Rubbo
Homero
H
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D050197:Atherosclerosis / Q000517:prevention & control*; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D009569:Nitric Oxide / Q000737:chemistry*; D020030:Nitric Oxide Donors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013055:Spectrophotometry, Infrared; D024505:Tocopherols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D000975:Antioxidants; D020030:Nitric Oxide Donors; D014665:Vasodilator Agents; D009569:Nitric Oxide; D024505:Tocopherols