Glycosidase inhibition by 1-glycosyl-4-phenyl triazoles.
1-Glycosyl-4-phenyl triazoles have been prepared via a copper-mediated [3+2] cycloaddition of glycosyl azides with phenylacetylene. These triazoles have been evaluated for their ability to inhibit the enzymatic activity of glycosidases.
Rossi
Lauren L
LL
Department of Chemistry, Brown University, Providence, RI 02912, USA.
Basu
Amit
A
D000114:Acetylene / Q000031:analogs & derivatives / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006027:Glycosides / Q000138:chemical synthesis / Q000494:pharmacology; D006868:Hydrolysis; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis / Q000494:pharmacology
D001386:Azides; D004791:Enzyme Inhibitors; D006027:Glycosides; D014230:Triazoles; C044736:phenylacetylene; D003300:Copper; D006026:Glycoside Hydrolases; D000114:Acetylene