Sublethal concentrations of ciprofloxacin induce bacteriocin synthesis in Escherichia coli.
Antibiotics that interfere with DNA replication, as well as cell wall synthesis, induce the SOS response. In this report, we show that ciprofloxacin induces synthesis of colicins, narrow-spectrum antibiotics frequently produced by Escherichia coli strains, in an SOS-dependent manner.
Jerman
Borut
B
Department of Biology, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, Ljubljana, Slovenia.
Butala
Matej
M
Zgur-Bertok
Darja
D
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D003087:Colicins / Q000096:biosynthesis*; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D013014:SOS Response, Genetics
D000900:Anti-Bacterial Agents; D003087:Colicins; D029968:Escherichia coli Proteins; D002939:Ciprofloxacin