Cytotoxic ent-kaurane diterpenoids from Isodon weisiensis C. Y. Wu.
A new ent-kaurane diterpenoid, weisiensin B (1), was isolated from the leaves of Isodon weisiensis C. Y. Wu, along with four known ones, kamebanin (2), kamebacetal A (3), macrocalyxin D (4) and excisanin D (5). Their structures were determined by spectroscopic means. Compound 1-4 showed significant cytotoxic activity against Bel-7402 and HO-8910 cells.
College of Life Science, Northwest Normal University, Lanzhou, PR China. dinglan641@sina.com
Lan
L
Ding
Guo-Ah
GA
Liu
Dong-Juan
DJ
Yang
Han
H
Wang
Lai
L
Wang
Kun
K
Sun
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D018515:Plant Leaves; D013056:Spectrophotometry, Ultraviolet
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes