Highly diastereoselective Diels-Alder reactions with enantiopure sulfinyl-substituted 1-hydroxymethyldienes.
Enantiopure hydroxy-2- and -3-sulfinyldienes undergo highly selective Diels-Alder cycloadditions with various dienophiles controlled by the chiral sulfur atom. The related hydroxy-2-sulfonyldienes display complementary pi-facial selectivity.
Instituto de Química Orgánica, CSIC, Juan de la Cierva, 3, 28006 Madrid, Spain.
Roberto
R
Fernández de la Pradilla
Carlos
C
Montero
Mariola
M
Tortosa
Alma
A
Viso