[Changes of the concentration of lipid peroxidation products and thiol groups in rat brains with long-term intoxication with methanol].
The aim of this paper was to define the influence of long-term methanol intoxication on the changes of end products of lipid peroxidation, reacting with thiobarbituric acid (TBA-reactive products) and free SH-group concentration in rat brains. The experiment was conducted on male Lewis rats. The experimental groups received a 1-molar methanol solution and the control group received tap water. The animals were killed after 4, 8 and 12 weeks of intoxication and their brains were collected for further examination, which encompassed measurement of the concentration of TBA-reactive products and free SH-groups. The revealed changes of TBA-reactive products and free SH-group concentration were not statistically significant.
Katedra i Zakład Medycyny Sadowej, Uniwersytetu Medycznego w Lodzi. mbarzdo@wp.pl
Maciej
M
Barzdo
Ewa
E
Gloc
Ewa
E
Meissner
Agnieszka P
AP
Jurczyk
Beata
B
Jankowska
Jarosław
J
Berent
Stefan
S
Szram
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D001923:Brain Chemistry; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D000432:Methanol / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects; D011897:Random Allocation; D051381:Rats; D011917:Rats, Inbred Lew; D013438:Sulfhydryl Compounds / Q000378:metabolism*; D013858:Thiobarbiturates / Q000737:chemistry; D013997:Time Factors
D013438:Sulfhydryl Compounds; D013858:Thiobarbiturates; C029684:thiobarbituric acid; D000432:Methanol