[Intraarterial concomitant chemoradiation for tongue cancer: analysis of 20 patients].
Subjects were 20 patients with tongue cancer treated between April 1996 and December 2002 with intraarterial infusion of cisplatin (60-120 mg/m2) (and docetaxel 10-30 mg/m2) and intravenous infusion of sodium thiosulfate followed by 5-fluorouracil (5-FU) (800-1000 mg/m2) for 3 to 5 days. All patients underwent radiation (50-80 Gy). Ten had stage II, 4 stage III, and 6 stage IV A disease. Complete response at the primary site was achieved in 50% for T2, 67% for T3, and 0% for T4 lesions in those undergoing IA cisplatin followed by systemic 5-FU with concurrent radiation. Complete response at the primary site was achieved in all patients given IA cisplatin and docetaxel followed by systemic 5-FU with concurrent radiation. Disease-specific survival was 75% and overall survival 69% at 5 years. Side effects of treatment were tolerable, except for grade three radiomucositis in 70% of patients and grade three bone marrow depression in one treated with weekly IA chemotherapy.
Department of Otorhinolaryngology-Head and Neck Surgery, Nihon University School of Medicine, Tokyo.
Sohei
S
Endo
Shin
S
Suzuki
Kenzo
K
Tsuji
Hideo
H
Niwa
Yugo
Y
Noguchi
Kenji
K
Yoshida
Akinori
A
Kida
Yoshiaki
Y
Tanaka
Kazuhisa
K
Himi
Akiko
A
Takemoto
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D000077143:Docetaxel; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D043823:Taxoids / Q000008:administration & dosage; D013885:Thiosulfates / Q000008:administration & dosage; D014062:Tongue Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*
D043823:Taxoids; D013885:Thiosulfates; D000077143:Docetaxel; C017717:sodium thiosulfate; D002945:Cisplatin; D005472:Fluorouracil