50gram oral glucose challenge test combined with risk factor-based screening for gestational diabetes.
OBJECTIVE
Our aim was to study whether universal screening of all pregnant women by Oral Glucose Challenge Test (OGCT) would identify a higher number of women with Gestational Diabetes (GDM) than risk factor based screening.


METHODS
A 50 g OGCT test was performed prospectively in 532 unselected women at 26-28 weeks of gestation. The 1-h venous plasma glucose concentration of >7.3 mmol/l was considered as a positive screening result. Patients with a positive OGCT underwent a 75 g 2-h OGTT, which was used as the actual diagnostic test for GDM. When two or all three of the glucose concentrations in OGTT (measured at fasting state and 1 and 2 h after the 75 g glucose load) were above the 97.5th percentile the patient was considered as having GDM. In addition, women with risk factors for GDM also underwent a 75 g OGTT regardless of the result of the OGCT.


RESULTS
A positive 50 g OGCT was obtained in 123 (23%) of the women. In 15 (12%) of these, a diagnosis of GDM was established by the subsequent OGTT. Out of the 409 remaining women with a normal OGCT, 148 (36%) had risk factors for GDM. An OGTT performed in these patients identified 4 additional women with a GDM. Seventy-nine percent of GDM was thus found with 50g OGCT without regarding risk factors. Forty-seven percent of the women with GDM would have been missed in screening by risk factors only.


CONCLUSIONS
In our population 50 g OGCT appears to identify a higher number of GDM than risk factor based screening. Combined with risk factor screening a few more cases of GDM would be found.
Pöyhönen-Alho
Maritta K
MK
Department of Gynecology and Obstetrics, Helsinki University Central Hospital, Finland. maritta.poyhonen-alho@hus.fi
Teramo
Kari A
KA
Kaaja
Risto J
RJ
Hiilesmaa
Vilho K
VK
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D001786:Blood Glucose / Q000032:analysis*; D016640:Diabetes, Gestational / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D005947:Glucose; D005951:Glucose Tolerance Test; D006801:Humans; D015994:Incidence; D008403:Mass Screening; D008423:Maternal Age; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000453:epidemiology; D011262:Pregnancy Trimester, Second; D011295:Prenatal Care / Q000379:methods; D011446:Prospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity
D001786:Blood Glucose; D005947:Glucose