Progressive increase in antimicrobial resistance among invasive isolates of Haemophilus influenzae obtained from children admitted to a hospital in Kilifi, Kenya, from 1994 to 2002.
Etest susceptibilities to amoxicillin, chloramphenicol, and trimethoprim-sulfamethoxazole of 240 invasive isolates of Haemophilus influenzae cultured from children in rural Kenya were 66%, 66%, and 38%, respectively. Resistance increased markedly over 9 years and was concentrated among serotype b isolates. In Africa, the increasing cost of treating resistant infections supports economic arguments for prevention through conjugate H. influenzae type b immunization.
Wellcome Trust/Kenya Medical Research Institute, Centre for Geographic Medicine Research--Coast, P.O. Box 230, Kilifi, Kenya. pneumo@ikilifi.net.
J Anthony G
JA
Scott
Salim
S
Mwarumba
Caroline
C
Ngetsa
Salome
S
Njenga
Brett S
BS
Lowe
Mary P E
MP
Slack
James A
JA
Berkley
Isaiah
I
Mwangi
Kathryn
K
Maitland
Mike
M
English
Kevin
K
Marsh
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D005260:Female; D006192:Haemophilus Infections / Q000453:epidemiology* / Q000382:microbiology; D006193:Haemophilus influenzae / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D019741:Haemophilus influenzae type b / Q000187:drug effects / Q000302:isolation & purification; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007630:Kenya; D008297:Male; D008583:Meningitis, Haemophilus / Q000453:epidemiology / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D018410:Pneumonia, Bacterial / Q000453:epidemiology / Q000382:microbiology
D000900:Anti-Bacterial Agents