A new FronTIR in targeted protein degradation and plant development.
Three papers, two in a recent issue of Nature and one in the July issue of Developmental Cell, identify a family of F box proteins as the long-sought receptors for the plant growth hormone auxin. The new studies reveal that auxin, a small molecule, regulates F box proteins, which are involved in ubiquitin-mediated protein degradation. This finding has profound implications for understanding plant physiology and development and for defining new modes of regulation of SCF ubiquitin ligase complexes.
Nemhauser
Jennifer L
JL
Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.
Chory
Joanne
J
D029681:Arabidopsis Proteins; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D044783:F-Box Proteins / Q000378:metabolism*; D018506:Gene Expression Regulation, Plant / Q000502:physiology; D007210:Indoleacetic Acids / Q000378:metabolism*; D010940:Plant Proteins; D010944:Plants / Q000196:embryology* / Q000235:genetics / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D044843:SKP Cullin F-Box Protein Ligases / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D015533:Transcriptional Activation / Q000502:physiology; D025801:Ubiquitin / Q000378:metabolism
C503841:ARF1 protein, Arabidopsis; D029681:Arabidopsis Proteins; D004268:DNA-Binding Proteins; D044783:F-Box Proteins; D007210:Indoleacetic Acids; D010940:Plant Proteins; D011956:Receptors, Cell Surface; D012097:Repressor Proteins; C501405:TIR1 protein, Arabidopsis; D014157:Transcription Factors; D025801:Ubiquitin; D044843:SKP Cullin F-Box Protein Ligases