Polymorphisms in the SLC2A2 (GLUT2) gene are associated with the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study.
Impaired insulin secretion is a fundamental defect in type 2 diabetes. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in the genes regulating insulin secretion (SLC2A2 [encoding GLUT2], GCK, TCF1 [encoding HNF-1alpha], HNF4A, GIP, and GLP1R) are associated with the conversion from impaired glucose tolerance (IGT) to type 2 diabetes in participants of the Finnish Diabetes Prevention Study. With the exception of SLC2A2, other genes were not associated with the risk of type 2 diabetes. All four SNPs of SLC2A2 predicted the conversion to diabetes, and rs5393 (AA genotype) increased the risk of type 2 diabetes in the entire study population by threefold (odds ratio 3.04, 95% CI 1.34-6.88, P = 0.008). The risk for type 2 diabetes in the AA genotype carriers was increased in the control group (5.56 [1.78-17.39], P = 0.003) but not in the intervention group. We conclude that the SNPs of SLC2A2 predict the conversion to diabetes in obese subjects with IGT.
Department of Medicine, University of Kuopio, 70210 Kuopio, Finland.
Olli
O
Laukkanen
Jaana
J
Lindström
Johan
J
Eriksson
Timo T
TT
Valle
Helena
H
Hämäläinen
Pirjo
P
Ilanne-Parikka
Sirkka
S
Keinänen-Kiukaanniemi
Jaakko
J
Tuomilehto
Matti
M
Uusitupa
Markku
M
Laakso
D000704:Analysis of Variance; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000517:prevention & control; D018450:Disease Progression; D005387:Finland; D005838:Genotype; D018149:Glucose Intolerance / Q000235:genetics*; D051273:Glucose Transporter Type 2; D006801:Humans; D009004:Monosaccharide Transport Proteins / Q000235:genetics*; D015999:Multivariate Analysis; D009765:Obesity / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
D051273:Glucose Transporter Type 2; D009004:Monosaccharide Transport Proteins