Choosing the correct functional assay: a comprehensive assessment of functional tests in the rat.
While there are several ways to quantify peripheral nerve regeneration; the true measure of successful outcome is functional recovery. Functional tests are relatively easily conducted in human subjects; however it is more difficult in a laboratory animal. The laboratory rat is an excellent animal model of peripheral nerve injury and has been used extensively in the field of peripheral nerve research. Due to the intense interest in the rat as an experimental model, functional assays have been reported. In an effort to provide a resource to which investigators can refer when considering the most appropriate functional assay for a given experiment, the authors have compiled and tabulated the available functional tests applicable to various models of rat nerve injury.
Nichols
Chris M
CM
Washington University School of Medicine, Division of Plastic and Reconstructive Surgery, Campus Box 8238, St. Louis, MO 63110, USA.
Myckatyn
Terence M
TM
Rickman
Susan R
SR
Fox
Ida K
IK
Hadlock
Tessa
T
Mackinnon
Susan E
SE
D000818:Animals; D001696:Biomechanical Phenomena / Q000379:methods; D005121:Extremities / Q000503:physiopathology; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D010523:Peripheral Nervous System Diseases / Q000503:physiopathology*; D051381:Rats; D020127:Recovery of Function / Q000502:physiology*; D012677:Sensation / Q000502:physiology; D014738:Vibrissae / Q000294:innervation / Q000502:physiology