Delayed onset bleomycin-induced pneumonitis.
We describe a 39-year-old male patient who developed bleomycin-induced pneumonitis 2 years after completion of chemotherapy for nonseminomatous testicular cancer. Bleomycin sometimes causes fatal pulmonary toxicity, including bleomycin-induced pneumonitis. The central event in the development of pneumonitis is endothelial damage of the lung vasculature due to bleomycin-induced cytokines and free radicals. Pulmonary toxicity usually begins at bleomycin administration. The development of bleomycin-induced pneumonitis up to 6 months after bleomycin therapy has also been reported. We report a patient who developed bleomycin-induced pneumonitis 2 years after the initiation of bleomycin-containing chemotherapy regimens.
Uzel
I
I
Department of Pulmonary Diseases, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
Ozguroglu
M
M
Uzel
B
B
Kaynak
K
K
Demirhan
O
O
Akman
C
C
Oz
F
F
Yaman
M
M
D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D001761:Bleomycin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D011014:Pneumonia / Q000139:chemically induced*; D013736:Testicular Neoplasms / Q000188:drug therapy; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D001761:Bleomycin