Gastrointestinal symptoms in spinal cord injury: relationships with level of injury and psychologic factors.
BACKGROUND
Previous surveys of gastrointestinal symptoms after spinal cord injury have not used validated questionnaires and have not focused on the full spectrum of such symptoms and their relationship to factors, such as level of spinal cord injury and psychologic dysfunction. This study was designed to detail the spectrum and prevalence of gastrointestinal symptoms in spinal cord injury and to determine clinical and psychologic factors associated with such symptoms.


METHODS
Established spinal cord injury patients (>12 months) randomly selected from a spinal cord injury database completed the following three questionnaires: 1) Rome II Integrative Questionnaire, 2) Hospital Anxiety and Depression Scale, and 3) Burwood Bowel Dysfunction after spinal cord injury.


RESULTS
A total of 110 patients participated. The prevalence of abdominal bloating and constipation were 22 and 46 percent, respectively. Bloating was associated with cervical (odds ratio = 9.5) and lumbar (odds ratio = 12.1) level but not with thoracic level of injury. Constipation was associated with a higher level of injury (cervical odds ratio = 5.6 vs. lumbar) but not with psychologic factors. In contrast, abdominal pain (33 percent) and fecal incontinence (41 percent) were associated with higher levels of anxiety (odds ratio = 6.8, and odds ratio = 2.4) but not with the level of injury.


CONCLUSIONS
There is a high prevalence and wide spectrum of gastrointestinal symptoms in spinal cord injury. Abdominal bloating and constipation are primarily related to specific spinal cord levels of injury, whereas abdominal pain and fecal incontinence are primarily associated with higher levels of anxiety. Based on our findings, further physiologic and psychologic research studies in spinal cord injury patients should lead to more rational management strategies for the common gastrointestinal symptoms in spinal cord injury.
Gastrointestinal Investigation Unit, Royal North Shore Hospital, University of Sydney, Department of Gastroenterology, Royal North Shore Hospital, St. Leonards NSW, Sydney, 2065, Australia.
Clinton
C
Ng
Gillian
G
Prott
Susan
S
Rutkowski
Yueming
Y
Li
Ross
R
Hansen
John
J
Kellow
Allison
A
Malcolm
D015746:Abdominal Pain / Q000209:etiology / Q000523:psychology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001007:Anxiety / Q000145:classification / Q000523:psychology; D002574:Cervical Vertebrae; D003248:Constipation / Q000209:etiology / Q000523:psychology; D003863:Depression / Q000145:classification / Q000523:psychology; D005242:Fecal Incontinence / Q000209:etiology / Q000523:psychology; D005260:Female; D005740:Gases; D005767:Gastrointestinal Diseases / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D013119:Spinal Cord Injuries / Q000145:classification / Q000150:complications* / Q000523:psychology; D011795:Surveys and Questionnaires; D013904:Thoracic Vertebrae
D005740:Gases