Primitive neuroectodermal tumor of the cervix uteri: a case report -- changing concepts in therapy.
BACKGROUND
Peripheral primitive neuroectodermal tumor (PNET) of the cervix uteri is extremely rare. Between 1987 and 2002, there have been eight cases described in the English literature. The treatment policies in these eight cases differed considerably, partly due to the rarity of the disease and to differing time periods of diagnosis and treatment.


METHODS
At the end of 2002, a 21-year-old woman presented with a PNET of the cervix uteri at our institute, the Erasmus Medical Center. For the appropriate treatment in this case, we reviewed the literature and decided that the treatment should be different from the local surgical treatment followed by additional treatments as most of the earlier reports describe.


CONCLUSIONS
In view of the current knowledge of PNET belonging to the family of Ewing's sarcoma, and the improvement of treatment outcome in these tumors due to dose-intensive neo-adjuvant chemotherapy, patients with PNET of the cervix should be treated in accordance to the protocol for bony Ewing's sarcoma with multimodality therapy by means of induction chemotherapy, surgery, and consolidation chemotherapy.
Snijders-Keilholz
A
A
Erasmus University Medical Center, Daniel den Hoed Cancer Center, PO-Box 5201, 3008 AE Rotterdam, The Netherlands. a.snijders-keilholz@erasmusmc.nl
Ewing
P
P
Seynaeve
C
C
Burger
C W
CW
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003609:Dactinomycin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D015080:Mesna / Q000008:administration & dosage; D020360:Neoadjuvant Therapy; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000188:drug therapy* / Q000601:surgery*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D014750:Vincristine / Q000008:administration & dosage
D003609:Dactinomycin; D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D015080:Mesna; D007069:Ifosfamide