Anti-proliferative activity of essential oil extracted from Thai medicinal plants on KB and P388 cell lines.
Anti-proliferative activity of essential oil from 17 Thai medicinal plants on human mouth epidermal carcinoma (KB) and murine leukemia (P388) cell lines using MTT assay were investigated. An amount of 1 x 10(4)cells/well of KB cell line and 1 x 10(5) cells/well of P388 cell line were treated with the oil samples at different concentrations ranging from 0.019 to 4.962 mg/ml. In KB cell line, Guava (Psidium guajava L.) leaf oil showed the highest anti-proliferative activity with the IC(50) value of 0.0379 mg/ml (4.37 times more potent than vincristine) whereas Sweet Basil (Ocimum basilicum L.) oil gave the highest anti-proliferative activity with the IC(50) value of 0.0362 mg/ml (12.7 times less potent than 5-FU) in P388 cell line. The results demonstrated the potential of essential oil from Thai medicinal plants for cancer treatment.
Manosroi
Jiradej
J
Pharmaceutical-Cosmetic Raw Materials and Natural Products Research and Development Center, PCRNC, Institute for Science and Technology Research and Development, Chiang Mai University, Chiang Mai 50200, Thailand. pmpti006@chiangmai.ac.th
Dhumtanom
Pongsathorn
P
Manosroi
Aranya
A
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects*; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D018649:Ocimum basilicum / Q000737:chemistry; D009822:Oils, Volatile / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010938:Plant Oils / Q000494:pharmacology*; D010946:Plants, Medicinal; D031647:Psidium / Q000737:chemistry; D014750:Vincristine / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D009822:Oils, Volatile; D010938:Plant Oils; D014750:Vincristine