Thymoma and hypogammaglobulinemia (Good's syndrome): a case report.
Good's syndrome is extremely rare and refers to an acquired B and T cell immunodeficiency in thymoma patients. We report a 51-year-old female thymoma patient who presented with recurrent herpes zoster, pneumonia, diarrhea and opportunistic infections. She was found to have acquired hypogammaglobulinemia with absent B cells. Despite repeat intravenous immunoglobulin replacement and antibiotic therapy, she died of bacterial pneumonia-induced acute respiratory distress syndrome. Clinicians should look for evidence of immunologic dysfunction in thymoma patients presenting with recurrent infections.
Tsai
Yi-Giien
YG
Department of Pediatrics, Christian Hospital, Institute of Medical Research, Chang Jung Christian University, Changhua, Taiwan.
Lai
Jenn-Haung
JH
Kuo
San-Yuan
SY
Chen
Hsiang-Cheng
HC
Chang
Deh-Ming
DM
D000361:Agammaglobulinemia / Q000150:complications*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008875:Middle Aged; D013945:Thymoma / Q000150:complications*; D013953:Thymus Neoplasms / Q000150:complications*