The regional rule for bacterial base composition.
If one looks at the composition of coding DNA and of three types of intergenic regions--those between convergent, parallel and divergent genes--a striking pattern is seen in a wide range of bacteria. The AT-content of coding sequence is lowest, and the AT-contents of the intergenic regions increase in the order: convergent, parallel and divergent. Why does this pattern occur? In this article, I suggest an explanation based on the structural requirements for the binding of transcription factors.
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. gjm@mrc-lmb.cam.ac.uk
Graeme
G
Mitchison
D001419:Bacteria / Q000235:genetics* / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism; D001482:Base Composition; D001665:Binding Sites / Q000235:genetics; D004269:DNA, Bacterial / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D016680:Genome, Bacterial; D008957:Models, Genetic; D009690:Nucleic Acid Conformation; D013816:Thermodynamics; D014157:Transcription Factors / Q000378:metabolism
D001426:Bacterial Proteins; D004269:DNA, Bacterial; D014157:Transcription Factors