Intra-Golgi transport: a way to a new paradigm?
The morpho-functional principles of intra-Golgi transport are, surprisingly, still not clear, which is in marked contrast to our advanced knowledge of the underlying molecular machineries. Recently, the conceptual and technological hindrances that had delayed progress in this area have been disappearing, and a cluster of powerful morphological techniques has been revealing new glimpses of the organization of traffic in intact cells. Here, we discuss the new concepts around the present models of intra-Golgi transport.
Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro (Chieti), Italy. mironov@negrisud.it
Alexander A
AA
Mironov
Galina V
GV
Beznoussenko
Roman S
RS
Polishchuk
Alvar
A
Trucco
D000818:Animals; D001692:Biological Transport; D006801:Humans; D008954:Models, Biological; D033921:Vesicular Transport Proteins / Q000378:metabolism*; D021601:trans-Golgi Network / Q000378:metabolism* / Q000648:ultrastructure
D033921:Vesicular Transport Proteins