Quality of life of long-term survivors of breast cancer and lymphoma treated with standard-dose chemotherapy or local therapy.
OBJECTIVE
This study compared the quality of life (QOL) of long-term survivors of breast cancer and lymphoma who had been treated with standard-dose systemic chemotherapy or local therapy only.


METHODS
Long-term survivors (mean, 10.0 +/- 5.3 years after treatment) of breast cancer or lymphoma who had been treated with systemic chemotherapy (breast, n = 141, age = 57.0 +/- 10.1 years; lymphoma, n = 66, age = 55.8 +/- 13.5 years) or local therapy only (breast, n = 294, age = 65.8 +/- 9.1 years; lymphoma, n = 37, age = 50.4 +/- 12.8 years) were interviewed by phone using the Quality of Life-Cancer Survivors Tool.


RESULTS
Multivariate analysis of covariance, controlling for sex, age, education, stage of disease, and time since last treatment, revealed that survivors who had been treated with systemic chemotherapy scored significantly lower on overall QOL compared with survivors treated with local therapy only (P = .04). Analysis of covariance on the subscale scores revealed that, compared with survivors who received local therapy, survivors treated with chemotherapy scored significantly lower on the Social subscale (P < .0001), but no differences emerged on the Psychological or Spiritual subscales. There was a statistically significant interaction between treatment and diagnosis (P = .01), as measured by the Physical subscale, indicating that lymphoma survivors treated with chemotherapy scored worse than all other groups.


CONCLUSIONS
Important QOL differences emerged between the chemotherapy and local therapy groups, suggesting that long-term QOL may vary depending on the type of treatment and diagnosis.
Department of Psychiatry and Center for Psycho-Oncology Research, Dartmouth-Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH 03756, USA. Tim.A.Ahles@Dartmouth.edu
Tim A
TA
Ahles
Andrew J
AJ
Saykin
Charlotte T
CT
Furstenberg
Bernard
B
Cole
Leila A
LA
Mott
Linda
L
Titus-Ernstoff
Karen
K
Skalla
Marie
M
Bakitas
Peter M
PM
Silberfarb
D000223:Adaptation, Psychological; D000368:Aged; D001943:Breast Neoplasms / Q000523:psychology* / Q000628:therapy*; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects*; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008223:Lymphoma / Q000523:psychology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011788:Quality of Life; D017741:Survivors