Reactive oxygen species and aging: evolving questions.
Over the past 50 years, reactive oxygen species (ROS) have been investigated as putative mediators of the process of aging. As specific genes and pathways that are involved with ROS homeostasis have been linked to aging in lower organisms, such as Caenorhabditis elegans and Drosophila, the questions of how ROS regulate aging in higher organisms, and whether they do so to the same extent as in lower organisms, have emerged.
Dugan
Laura L
LL
Division of General Medicine and Geriatrics, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. ladugan@ucsd.edu
Quick
Kevin L
KL
D000375:Aging / Q000502:physiology*; D000818:Animals; D000975:Antioxidants / Q000502:physiology; D016922:Cellular Senescence / Q000502:physiology; D004330:Drosophila; D005609:Free Radicals; D006801:Humans; D008017:Life Expectancy; D008322:Mammals; D008928:Mitochondria; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000009:adverse effects*
D000975:Antioxidants; D005609:Free Radicals; D017382:Reactive Oxygen Species