[Dobutamine hemodynamics for aortic stenosis with left ventricular dysfunction].
Patients with aortic stenosis (AS) and left ventricular (LV) systolic dysfunction have a poor short-term prognosis. In this setting, the decrease in transaortic gradients has an independent prognostic value for operative risk and long-term outcome. The 2 main issues for these patients are: (1) The real severity of AS; (2) How to stratify operative risk and evaluate long-term prognosis. Dobutamine Hemodynamics has the potential to address these issues. In case of relative AS, valve area is increased by dobutamine (final valve area > 1.2 cm2 with a mean pressure gradient <30 mmHg); on the basis of published data, medical treatment is justified in this case. Left ventricular contractile reserve is defined an increase in stroke volume, by 20% or more, under dobutamine. Operative risk is between 5 and 11% in case of LV contractile reserve and long-term outcome is improved by surgery in this case. In contrast, operative risk varies from 30 to 60% in case of exhausted reserve; this risk is also determined by other factors such as the presence of coronary artery disease and associated comorbidities. All these parameters are factored into risk-benefit analysis in order to determine the best therapeutic approach for each patient.
Fédération de cardiologie, CHU Henri-Mondor, AP-HP, 51, avenue De-Lattre-de-Tassigny 94010 Créteil, France. jeanluc.monin@free.fr
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Monin
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Gueret
D001024:Aortic Valve Stenosis / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D002316:Cardiotonic Agents; D004280:Dobutamine; D006439:Hemodynamics; D006801:Humans; D018570:Risk Assessment; D012720:Severity of Illness Index; D013599:Systole; D018487:Ventricular Dysfunction, Left / Q000209:etiology
D002316:Cardiotonic Agents; D004280:Dobutamine