Protective effect of vitamin B6 in chromium-induced oxidative stress in liver.
The aim of this study was to examine the efficacy of vitamin B6 against chromium (Cr)-induced oxidative stress. Adult male albino Wistar rats (100-120 g) were used in this study. Potassium dichromate, a Cr VI compound, was administered at a dose of 127 mg kg(-1) p.o. Vitamin B6 (pyridoxine hydrochloride) was administered at a dose of 100 mg kg(-1) p.o. either alone or 12 h prior to Cr or simultaneously with Cr. Chromium treatment induced oxidative stress in the liver as measured by increased lipid peroxidation (LPO) and decreased vitamin C, vitamin E, glutathione (GSH), glutathione peroxidase (GPX), catalase (CAT), superoxide dismutase (SOD), glutathione S-transferase (GST) and glutathione reductase (GR). Both pre- and simultaneous treatments countered Cr-induced oxidative stress; pre-treatment was more effective than concurrent administration. The results demonstrate the antioxidant potential of vitamin B6.
Department of Pharmacology and Environmental Toxicology, Dr A. L. M. P.G. Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, TN, India. sanand@rx.uga.edu
Sathanandam S
SS
Anand
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001205:Ascorbic Acid / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D002857:Chromium / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D004798:Enzymes / Q000378:metabolism; D005978:Glutathione / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D025101:Vitamin B 6 / Q000627:therapeutic use*; D014810:Vitamin E / Q000627:therapeutic use
D000975:Antioxidants; D004798:Enzymes; D011506:Proteins; D002857:Chromium; D014810:Vitamin E; D025101:Vitamin B 6; D005978:Glutathione; D001205:Ascorbic Acid