[Possible candidates for the compound which is expected to attenuate dioxin toxicity].
This review deals with the three candidate compounds which may combat with dioxins' toxicity. Geranylgeranylacetone (GGA), an antiulcer drug, counteracts suppression of body weight gain and lethality produced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57BL/6J mice. Similarly, curcumin, a food ingredient anticipates the TCDD's toxicity on body weight gain. Both GGA and curcumin had no effect on the induction of hepatic ethoxyresorufin O-deethylase activity by TCDD. These data suggest that both compounds exhibit a protective effect against some forms of dioxin toxicity by a mechanism without involving inhibition of aryl hydrocarbon receptor activation. Further, the mechanism involved in resveratrol action on dioxin's toxicity was also discussed. Prior to the application of these compounds to Yusho patients, the limitation and possibility of these candidate compounds are seemed to be further studied.
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Yuji
Y
Ishii
Takumi
T
Ishida
Junpei
J
Mutoh
Hideyuki
H
Yamada
Kazuta
K
Oguri
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology / Q000627:therapeutic use; D003474:Curcumin / Q000494:pharmacology / Q000627:therapeutic use; D019363:Cytochrome P-450 CYP1A1; D004224:Diterpenes / Q000494:pharmacology / Q000627:therapeutic use; D005506:Food Contamination; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D012275:Oryza / Q000506:poisoning*; D010938:Plant Oils / Q000506:poisoning*; D011041:Poisoning / Q000188:drug therapy; D011078:Polychlorinated Biphenyls / Q000506:poisoning*; D000072317:Polychlorinated Dibenzodioxins / Q000037:antagonists & inhibitors / Q000633:toxicity; D018336:Receptors, Aryl Hydrocarbon; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology / Q000627:therapeutic use
D000897:Anti-Ulcer Agents; D004224:Diterpenes; D010938:Plant Oils; D000072317:Polychlorinated Dibenzodioxins; D018336:Receptors, Aryl Hydrocarbon; D013267:Stilbenes; D011078:Polychlorinated Biphenyls; D019363:Cytochrome P-450 CYP1A1; D003474:Curcumin; D000077185:Resveratrol; C031049:geranylgeranylacetone