Normal values for thrombelastography (ROTEM) and selected coagulation parameters in porcine blood.
The pig is a suitable animal model for researching blood coagulation and fibrinolysis. The present study therefore aimed to investigate in porcine blood the applicability of commercially available tests of coagulation and thrombelastography (ROTEM) and above all to determine normal values for coagulation parameters (e.g. prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin-antithrombin complexes (TAT), fibrinogen, antithrombin III (AT III), D-dimers, protein C). Except for the FibTEM and aPTT tests, all commercially available coagulation tests used were fully applicable for porcine blood. Normal values and reference intervals for porcine blood are given. As compared to the human reference intervals for the coagulation parameters investigated, porcine blood was found to be hypercoagulable.
Velik-Salchner
Corinna
C
Department of Anaesthesia and Intensive Care Medicine, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria. corinna.velik@uibk.ac.at
Schnürer
Christian
C
Fries
Dietmar
D
Müssigang
Peter R
PR
Moser
Patrizia L
PL
Streif
Werner
W
Kolbitsch
Christian
C
Lorenz
Ingo H
IH
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D001780:Blood Coagulation Tests; D015638:Cytochalasin D / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D023421:Models, Animal; D012016:Reference Values; D013552:Swine; D013916:Thrombelastography / Q000379:methods*
D015638:Cytochalasin D