Radiosynoviorthesis for treatment of hemophilic hemarthrosis--Slovenian experience.
Radiosynoviorthesis is a well-accepted method for the treatment of recurrent hemarthrosis in hemophilic patients.


OBJECTIVE
The aims of our study were to evaluate the effectiveness of radiosynoviorthesis in patients suffering from hemophilic hemarthrosis, to determine the effect of treatment on antihemophilic factor consumption, and to assess the patient's satisfaction with radiosynoviorthesis.


METHODS
Between 2001 and 2003, 26 radiosynoviortheses were done in 21 hemophilic patients; in 4 patients the treatment was repeated, and in 1 patient two joints were treated. 90Y colloid was used for the knee joint, and 186Re colloid was used for ankle, shoulder, and elbow radiosynoviorthesis.


RESULTS
The bleeding frequency decreased by at least 50% in 53% of patients in the year after radiosynoviorthesis, as compared to the year prior to the therapy. Considering only those patients who had at least 12 bleedings into the treated joints in the year preceding the therapy, the bleeding frequency decreased by at least 50% in 62% of these patients. In this group, the consumption of the antihemophilic factor was notably reduced (on average, by 25,800 I.U./year). All patients reported that the treated joint was much better or better than before the radiosynoviorthesis.


CONCLUSIONS
Radiosynoviorthesis is an effective method for the treatment of hemophilic hemarthrosis, particularly in patients with frequent intra-articular bleedings. The antihemophilic factor consumption was markedly reduced only in patients with frequent joint bleeding. Radiosynoviorthesis is well accepted by patients suffering from hemophilic hemarthrosis.
Grmek
Marko
M
Department for Nuclear Medicine, University Medical Center Ljubljana, Ljubljana, Slovenia. marko.grmek@guest.arnes.si
Milcinski
Metka
M
Fettich
Jurij
J
Benedik-Dolnicar
Majda
M
Brecelj
Janez
J
D000293:Adolescent; D000328:Adult; D002648:Child; D005500:Follow-Up Studies; D006395:Hemarthrosis / Q000150:complications* / Q000532:radiotherapy*; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D017524:Slovenia; D013585:Synovitis / Q000150:complications* / Q000532:radiotherapy*; D016896:Treatment Outcome