Multifunctional redox catalysts as selective enhancers of oxidative stress.
Certain cancer cells proliferate under conditions of oxidative stress (OS) and might therefore be selectively targeted by redox catalysts. Among these catalysts, compounds containing a chalcogen and a quinone redox centre are particularly well suited to respond to the presence of OS. These catalysts combine the specific electrochemical features of quinones and chalcogens. They exhibit high selectivity and efficiency against oxidatively stressed rat PC12, human Jurkat and human Daudi cells in cell culture, where their mode of action most likely involves the catalytic activation of existent and the generation of new reactive oxygen species. The high efficiency and selectivity shown by these catalysts makes them interesting for the development of anti-cancer drugs.
School of Biological and Chemical Sciences, University of Exeter, Stocker Road, Exeter, UK EX4 4QD.
Fiona H
FH
Fry
Andrea L
AL
Holme
Niroshini M
NM
Giles
Gregory I
GI
Giles
Catriona
C
Collins
Kim
K
Holt
Sandra
S
Pariagh
Thomas
T
Gelbrich
Michael B
MB
Hursthouse
Nick J
NJ
Gutowski
Claus
C
Jacob
D000818:Animals; D002384:Catalysis; D045744:Cell Line, Tumor; D018011:Chalcogens / Q000737:chemistry* / Q000494:pharmacology; D003579:Cytochrome Reductases / Q000737:chemistry*; D004563:Electrochemistry; D006801:Humans; D019169:Jurkat Cells; D008958:Models, Molecular; D015394:Molecular Structure; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D016716:PC12 Cells; D011809:Quinones / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D017382:Reactive Oxygen Species / Q000737:chemistry / Q000378:metabolism
D018011:Chalcogens; D011809:Quinones; D017382:Reactive Oxygen Species; D003579:Cytochrome Reductases