Hypoglycemic effect of Malmea depressa root on streptozotocin diabetic rats.
The hypoglycemic effects of water, ethanolic and butanolic extracts prepared from the root of Malmea depressa (Baill) R.E. Fries. (Annonaceae) were studied in diabetic rats (streptozotocin induced). Oral application of water extracts at doses of 40 and 80 mg/kg, ethanolic (112 mg/kg) and butanolic (80 mg/kg) extracts significantly lowered the plasma glucose levels in diabetic rats within three hours. Glibenclamide and metformin were used as references and showed similar hypoglycemic effects like the extracts. The three extracts have a similar chemical composition (HPLC analysis).
Andrade-Cetto
Adolfo
A
Departamento de Biologia Celular, Fac. Ciencias, Universidad National Autónoma de México, 04510 México DF, Mexico. aac@hp.fciencias.unam.mx
Martínez-Zurita
Eddy
E
Wiedenfeld
Helmut
H
D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D001786:Blood Glucose / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D000431:Ethanol; D005905:Glyburide / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D008519:Medicine, Traditional; D008687:Metformin / Q000494:pharmacology; D008800:Mexico; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012997:Solvents; D014867:Water
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D012997:Solvents; D014867:Water; D000431:Ethanol; D008687:Metformin; D005905:Glyburide