[Cytoprotective effects of bilirubin].
Bilirubin, a major product of heme catabolism, belongs to compounds with pleiotropic biologic effects. For a long time bilirubin was considered as a metabolite dangerous for human health, neonatologists know well serious clinical complication of neonatal jaundice called bilirubin encephalopathy. Nevertheless, recent data has demonstrated that bilirubin exhibits potent antioxidant and even anti-inflammatory effects with substantial clinical impacts. The aim of the present study was to summarize present knowledge in this rapidly evolving field and suggest further possible clinical consequences.
Ustav klinické biochemie a laboratorní diagnostiky a IV. interní klinika 1. LF UK a VFN, Praha. vitek@cesnet.cz
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Vítek
D001663:Bilirubin / Q000737:chemistry / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000503:physiopathology; D019610:Cytoprotection; D006801:Humans; D018384:Oxidative Stress
D001663:Bilirubin