[A case of curatively resected AFP producing gastric cancer that responded remarkably to 1 course of TS-1 and showed complete loss of multiple liver metastatic tumors].
A 73-year-old woman was admitted to our hospital for evaluation of hypochondralgia, and a thorough examination revealed an AFP producing gastric cancer with multiple liver metastases. One course of TS-1 100 mg/day for 4 weeks and discontinuation for 2 weeks was started from February, 2003. After 3 months, the level of AFP reduced remarkably from 53,700 ng/ml to the normal limit. The metastatic tumors in the liver showed regression, and after 14 months, CT scanning showed that the tumors had disappeared. Since the size of the original tumor showed no change, distal gastrectomy was performed, and curability A was achieved. We consider this rare case has significant value in terms of treatment of AFP producing gastric cancer with multiple liver metastases. We think the combination of surgery and chemotherapy such as TS-1 will lead to a better prognosis in such cases.
Dept. of Internal Medicine, Isawa Hospital.
Waku
W
Hatta
Shinji
S
Kumagai
Junji
J
Imamura
Tomoyuki
T
Oikawa
Yasunari
Y
Asano
Hiroshi
H
Fujita
Hiroki
H
Aizawa
Kenzo
K
Kaneko
Shouichi
S
Kayaba
Masashi
M
Sawada
Kazuyuki
K
Kusuda
Yu
Y
Suzuki
Kou
K
Takehana
Yoshihiro
Y
Endo
Michihiko
M
Kitamura
Goro
G
Kimizuka
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000378:metabolism / Q000556:secondary / Q000601:surgery; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary*; D010094:Oxonic Acid / Q000627:therapeutic use*; D011300:Preoperative Care; D011379:Prognosis; D011725:Pyridines / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000627:therapeutic use*; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; D011725:Pyridines; D000509:alpha-Fetoproteins; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid