HRPT2, a tumor suppressor gene for hyperparathyroidism-jaw tumor syndrome.
Hyperparathyroidism-jaw tumor (HPT-JT) syndrome is a familial multi-tumor syndrome resulting from inactivating mutations in the HRPT2 tumor suppressor gene, which encodes a protein product named parafibromin. Here, we will review recent advances in genetic and protein studies on parafibromin, and examine its biological functions.
Wang
P F
PF
Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick Avenue NE, Grand Rapids, MI 49503, USA.
Tan
M-H
MH
Zhang
C
C
Morreau
H
H
Teh
B T
BT
D049109:Cell Proliferation; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006961:Hyperparathyroidism / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D007573:Jaw Neoplasms / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D013577:Syndrome; D025521:Tumor Suppressor Proteins / Q000235:genetics* / Q000378:metabolism
C454900:CDC73 protein, human; D025521:Tumor Suppressor Proteins