Effects of preoperative administration of meloxicam on whole blood platelet aggregation, buccal mucosal bleeding time, and haematological indices in dogs undergoing elective ovariohysterectomy.
The purpose of the study was to evaluate the effect of preoperative administration of meloxicam, a non-steroidal anti-inflammatory drug used for pain control, on primary haemostasis in dogs. Twenty healthy female dogs undergoing elective ovariohysterectomy were enrolled in the study. Sixty minutes before pre-anaesthesia, a single dose of meloxicam (0.2 mg/kg) was randomly administered intravenously (IV) to 10 dogs (treatment group) while control dogs received an equivalent volume of saline solution IV. Platelet aggregation, buccal mucosa bleeding time, platelet count and haematological indices were measured at 0, 1, 6 and 24 h after administration of meloxicam. Since significant differences between groups were not observed for any of the measured parameters, preoperative administration of meloxicam may be used for pain control before elective ovariohysterectomy in healthy dogs, without compromising primary haemostasis.
Department of Animal Medicine and Surgery, Clinical Veterinary Hospital, Veterinary College of the Autonomous University of Barcelona, Bellaterra, O8193 Barcelona, Spain. laura.fresno@uab.es
Laura
L
Fresno
Javier
J
Moll
Begoña
B
Peñalba
Yvonne
Y
Espada
Anna
A
Andaluz
David
D
Prandi
Rafael
R
Ruiz de Gopegui
Félix
F
García
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D001760:Bleeding Time / Q000662:veterinary; D001774:Blood Chemical Analysis / Q000662:veterinary; D004285:Dogs / Q000502:physiology / Q000601:surgery*; D017558:Elective Surgical Procedures / Q000662:veterinary; D005260:Female; D007044:Hysterectomy / Q000662:veterinary; D007275:Injections, Intravenous / Q000662:veterinary; D000077239:Meloxicam; D009061:Mouth Mucosa; D010052:Ovariectomy / Q000662:veterinary; D010149:Postoperative Pain / Q000517:prevention & control / Q000662:veterinary*; D010974:Platelet Aggregation / Q000187:drug effects; D011300:Preoperative Care; D013843:Thiazines / Q000008:administration & dosage / Q000494:pharmacology*; D013844:Thiazoles / Q000008:administration & dosage / Q000494:pharmacology*; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013843:Thiazines; D013844:Thiazoles; D000077239:Meloxicam