No association of FOXP2 and PTPRZ1 on 7q31 with autism from the Japanese population.
Autism is a child-onset pervasive developmental disorder, with a significant role of genetic factors in its development. Genome-wide linkage studies have suggested a 7q region as a susceptibility locus for autism. We investigated several single nucleotide polymorphisms (SNPs) of Forkhead Box P2 (FOXP2) and Protein-Tyrosine Phosphatase, Receptor-type, Zeta-1 (PTPRZ1) at the 7q region in Japanese patients with autism and healthy controls. No significant difference was observed, after correction for the multiple testing, in allele, genotype or haplotype frequencies of the SNPs of FOXP2 or PTPRZ1 between patients and controls. No evidence was thus obtained for a major role of FOXP2 or PTPRZ1 in the development of autism.
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Tetsuya
T
Marui
Shinko
S
Koishi
Ikuko
I
Funatogawa
Kenji
K
Yamamoto
Hideo
H
Matsumoto
Ohiko
O
Hashimoto
Eiji
E
Nanba
Chieko
C
Kato
Michiko
M
Ishijima
Keiichiro
K
Watanabe
Kiyoto
K
Kasai
Nobumasa
N
Kato
Tsukasa
T
Sasaki
D000293:Adolescent; D000328:Adult; D001321:Autistic Disorder / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002897:Chromosomes, Human, Pair 7; D016001:Confidence Intervals; D005260:Female; D051858:Forkhead Transcription Factors; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology / Q000208:ethnology; D015810:Linkage Disequilibrium; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*
C465448:FOXP2 protein, human; D051858:Forkhead Transcription Factors; D014157:Transcription Factors; D017027:Protein Tyrosine Phosphatases