Foxl2 gene and the development of the ovary: a story about goat, mouse, fish and woman.
In this review, we describe recent results concerning the genetics of sex determination in mammals. Particularly, we developed the study of the FOXL2 gene and its implication in genetic anomalies in goats (PIS mutation) and humans (BPES). We present the expression of FOXL2 in the ovaries of different species.
Baron
Daniel
D
Equipe Sexualité et Reproduction, INRA-SCRIBE, Département PHASE, Campus de Beaulieu, 35042 Rennes Cedex, France. ellous@cochin.inserm.fr
Batista
Frank
F
Chaffaux
Stéphane
S
Cocquet
Julie
J
Cotinot
Corinne
C
Cribiu
Edmond
E
De Baere
Elfride
E
De Baeree
Elfride
E
Guiguen
Yann
Y
Jaubert
Francis
F
Pailhoux
Eric
E
Pannetier
Maëlle
M
Vaiman
Daniel
D
Vigier
Bernard
B
Veitia
Reiner
R
Fellous
Marc
M
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D012734:Disorders of Sex Development; D005260:Female; D005399:Fishes; D000074842:Forkhead Box Protein L2; D051858:Forkhead Transcription Factors; D018507:Gene Expression Regulation, Developmental; D006041:Goats; D006801:Humans; D008297:Male; D051379:Mice; D010053:Ovary / Q000196:embryology* / Q000378:metabolism; D019849:Sex Determination Processes; D013045:Species Specificity; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; C421604:FOXL2 protein, human; D000074842:Forkhead Box Protein L2; D051858:Forkhead Transcription Factors; C498893:Foxl2 protein, mouse; D014157:Transcription Factors