Expeditious approach to 5-aroyl-pyrrolidinones by a novel PIFA-mediated alkyne amidation reaction.
[reaction: see text] A novel metal-free approach to the alkyne amidation reaction is presented. The oxidation of properly substituted amides by the hypervalent iodine reagent PIFA provides the generation of a nitrenium ion that can react intramolecularly with a triple bond, leading to the construction of the title compounds.
Departamento de Química Orgánica II, Facultad de Ciencia y Tecnología, Euskal Herriko Unibertsitatea, Bilbao, Spain.
Sonia
S
Serna
Imanol
I
Tellitu
Esther
E
Domínguez
Isabel
I
Moreno
Raul
R
Sanmartín