In vitro inhibition of Helicobacter pylori by micromycetes.
The anti-Helicobacter pylori effect of 22 micromycetes were studied against one standard strain and 11 clinical isolates of H. pylori. Penicillium ochlochloron and Penicillium funiculosum have been proven the most active fungi against this microorganism. Further bio-guided chemical analysis of P. funiculosum afforded an active component identified as (-) 2,3,4-trihydroxybutanamide.
Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, Panepistimiopolis, Zografou, 15771 Athens, Greece.
George
G
Stamatis
Ana
A
Rancić
Marina
M
Soković
Jelena
J
Vukojević
Panayiotis
P
Kyriazopoulos
Spyros
S
Triantaphyllidis
Spyros
S
Skaltsas
Helen
H
Skaltsa
D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D000898:Antibiosis; D005658:Fungi / Q000378:metabolism*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000254:growth & development*; D006885:Hydroxybutyrates / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
C506026:2,3,4-trihydroxybutanamide; D000900:Anti-Bacterial Agents; D006885:Hydroxybutyrates