C-reactive protein levels in non-obese pregnant women with gestational diabetes.
A low-grade systemic inflammation is concomitant in diabetes. There is a pathophysiological relation between gestational diabetes mellitus and type 2 diabetes mellitus, which was further supported by significantly elevated risk of type 2 diabetes in women with a history of previous gestational diabetes mellitus. We investigated the relation between low-grade systemic inflammation expressed as C-reactive protein and gestational diabetes in non-obese pregnant women. This study included 20 non-obese pregnant women with gestational diabetes mellitus and 30 non-obese pregnant women without gestational diabetes mellitus as a control group. The body mass index of all the subjects were < 25 kg/m2. During 26-28 gestational weeks 100-g oral glucose tolerance test was performed and simultaneously fasting C-reactive protein levels were measured. Serum median C-reactive protein level was higher in patients with gestational diabetes mellitus (p = 0.0001). C-reactive protein was strongly associated with glycemic parameters and weight gain during pregnancy. A model consisting of glucose intolerance, age, parity, and weight gain during pregnancy accounted for 61% of the variance in log C-reactive protein. We demonstrated that serum C-reactive protein level was related with gestational diabetes mellitus and weight gain during pregnancy in late second and early third trimesters.
Department of Biochemistry, Faculty of Medicine, Pamukkale University, Denizli, Turkey. siminrota@yahoo.co.uk
Simin
S
Rota
Başak
B
Yildirim
Babür
B
Kaleli
Hülya
H
Aybek
Koray
K
Duman
Bünyamin
B
Kaptanoğlu
D000328:Adult; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005865:Gestational Age; D005951:Glucose Tolerance Test; D006801:Humans; D007249:Inflammation / Q000097:blood; D011247:Pregnancy; D011264:Pregnancy Trimesters
D002097:C-Reactive Protein