Discovery and in vitro evaluation of potent kinase inhibitors: Pyrido[1',2':1,5]pyrazolo[3,4-d]pyrimidines.
The discovery, synthesis, potential binding mode, and in vitro kinase profile of several pyrido[1',2':1,5]pyrazolo[3,4-d]pyrimidines as potent kinase inhibitors are discussed.
GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA.
Michael J
MJ
Alberti
Elizabeth P
EP
Auten
Karen E
KE
Lackey
Octerloney B
OB
McDonald
Edgar R
ER
Wood
Frank
F
Preugschat
Geoffrey J
GJ
Cutler
Laurie
L
Kane-Carson
Wei
W
Liu
David K
DK
Jung
D006801:Humans; D006860:Hydrogen Bonding; D015394:Molecular Structure; D011487:Protein Conformation; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011494:Protein Kinases / Q000187:drug effects*; D017434:Protein Structure, Tertiary; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D011494:Protein Kinases