Allosterism at muscarinic receptors: ligands and mechanisms.
The evaluation of allosteric ligands at muscarinic receptors is discussed in terms of the ability of the experimental data to be interpreted by the allosteric ternary complex model. The compilation of useful SAR information of allosteric ligands is not simple, especially for muscarinic receptors, where there are multiple allosteric sites and complex interactions.
Birdsall
N J M
NJ
Division of Physical Biochemistry, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK. nbirdsa@nimr.mrc.ac.uk
Lazareno
S
S
D000818:Animals; D018678:Cholinergic Agents / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008024:Ligands; D011976:Receptors, Muscarinic / Q000737:chemistry* / Q000145:classification / Q000187:drug effects*; D013329:Structure-Activity Relationship
D018678:Cholinergic Agents; D008024:Ligands; D011976:Receptors, Muscarinic