[The study on skin wound healing promoting action of sodium usnic acid].
OBJECTIVE
To study the effects of sodium usnic acid on proliferation of fibroblasts and skin wound healing.


METHODS
L929 fibroblasts were incubated in culture medium containing sodium usnic acid, the proliferation of fibroblasts were measured by MTT. Skin wound healing promoting action of sodium usnic acid was determined in rats.


RESULTS
Sodium usnic acid does not showed proliferation-promoting activity for L929 fibroblasts, sodium usnic acid by external application accelerated healing of rat backskin wound. The wound-healing rate of sodium usnic acid was higher than that of the control group at the 2th - 12th day after treatment.


CONCLUSIONS
Sodium usnic acid can accelerate skin wound healing, the effects was not by stimulating proliferation of fibroblasts.
Jin
Juqing
J
Xi' an Jiaotong University, Xi'an 710061.
Dong
Yalin
Y
He
Langchong
L
D000287:Administration, Topical; D000818:Animals; D001572:Benzofurans / Q000008:administration & dosage / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005347:Fibroblasts / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000293:injuries; D020949:Usnea / Q000737:chemistry*; D014945:Wound Healing / Q000187:drug effects*
D001572:Benzofurans; D004365:Drugs, Chinese Herbal; C073339:usnic acid