Evaluation of radioprotective effects of Rajgira (Amaranthus paniculatus) extract in Swiss albino mice.
The radioprotective efficacy of aqueous extract of Rajgira (Amaranthus paniculatus) leaves against whole body gamma radiation was studied in Swiss albino mice. The oral administration of Rajgira extract at 800 mg/kg body weight/day for 15 consecutive days before whole body exposure to radiation was found to be effective with the LD50/30 values of 6.33 and 8.62 Gy for irradiation alone and Rajgira+irradiation group, respectively, giving a dose reduction factor of 1.36. This effect of Rajgira accompanied the increased endogenous spleen colonies and the spleen weight without any side effect or toxicity, as well as the modulation of the radiation-induced decrease of reduced glutathione and the radiation-induced increase in lipid peroxidation assessed in the liver and the blood.
Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, India.
Anita
A
Krishna
Ashok
A
Kumar
D000284:Administration, Oral; D027721:Amaranthus / Q000737:chemistry*; D000818:Animals; D001835:Body Weight / Q000187:drug effects / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004353:Drug Evaluation, Preclinical; D005720:Gamma Rays / Q000009:adverse effects*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage*; D018515:Plant Leaves / Q000737:chemistry*; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000209:etiology / Q000473:pathology* / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D013534:Survival; D016019:Survival Analysis; D016896:Treatment Outcome; D014916:Whole-Body Irradiation / Q000379:methods
D010936:Plant Extracts; D011837:Radiation-Protective Agents