Synthesis of novel curcumin mimics with asymmetrical units and their anti-angiogenic activity.
Novel curcumin mimics with asymmetrical units phenyl group with alkyl amide, chloro-substituted benzamide, or heteroaromatic amide moieties were synthesized and their anti-angiogenic activity was evaluated with the proliferation and tube formation inhibitory activity on the human umbilical vein endothelial cells. Compounds 5, 14, 17, and 18 showed potent growth inhibitory activity and tube formation inhibitory activity.
Department of Basic Sciences, Wonju College of Medicine, Yonsei University, Wonju 220-701, Republic of Korea.
Ho Bum
HB
Woo
Woon-Seob
WS
Shin
Seokjoon
S
Lee
Chan Mug
CM
Ahn
D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D003474:Curcumin / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D042783:Endothelial Cells / Q000187:drug effects; D006801:Humans; D018716:Molecular Mimicry; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D020533:Angiogenesis Inhibitors; D003474:Curcumin