Genotoxicity of thallium-201 in patients with angina pectoris undergoing myocardial perfusion study.
Thallium-201 (201Tl) has been widely used as a nuclear reagent for myocardial blood flow imaging. The purpose of this study was to investigate genotoxic effects of 201Tl in patients with angina pectoris (n = 21), who had undergone myocardial perfusion imaging. Lymphocytes were isolated from each patient before, and 3, 30 and 90 days after 201Tl administration (111 MBq, 3 mCi) and were analyzed for chromosomal aberrations, sister chromatid exchanges, mitotic index and replicative index. There were significant increases in chromosomal aberrations and sister chromatid exchanges 3 days after 201Tl administration (p < 0.001), although no difference was noted in these values after 30 and 90 days (p > 0.05). Moreover, decreased mitotic index and replicative index were noted after 3 days of 201Tl administration (p < 0.001). These results suggest that the administration of 201Tl for myocardial blood flow imaging may induce genetic damage.
Department of Nuclear Medicine, Ataturk University, Medical Faculty, Erzurum, Turkey. musyil@atauni.edu.tr
Mustafa
M
Yildirim
Mevlit
M
Ikbal
Tulay
T
Tos
Bedri
B
Seven
Ibrahim
I
Pirim
Erhan
E
Varoglu
D000787:Angina Pectoris / Q000175:diagnosis*; D002869:Chromosome Aberrations; D003326:Coronary Circulation; D004247:DNA / Q000528:radiation effects*; D004249:DNA Damage; D003952:Diagnostic Imaging; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009152:Mutagenicity Tests; D012039:Regional Blood Flow; D012854:Sister Chromatid Exchange; D013794:Thallium Radioisotopes / Q000009:adverse effects*; D013997:Time Factors
D013794:Thallium Radioisotopes; D004247:DNA