Smads and chromatin modulation.
Smad proteins are critical intracellular effector proteins and regulators of transforming growth factor type beta (TGFbeta) modulated gene transcription. They directly convey signals that initiate at ligand-bound receptor complexes and end in the nucleus with changes in programs of gene expression. Activated Smad proteins seem to recruit chromatin modifying proteins to target genes besides cooperating with DNA-bound transcription factors. We survey here the current and still emerging knowledge on Smad-binding factors, and their different mechanisms of chromatin modification in particular, in Smad-dependent TGFbeta signaling.
Department of Developmental Biology (VIB7), Flanders Interuniversity Institute for Biotechnology (VIB) and Laboratory of Molecular Biology (Celgen), University of Leuven, Belgium.
Leo A
LA
van Grunsven
Griet
G
Verstappen
Danny
D
Huylebroeck
Kristin
K
Verschueren
D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D042002:Chromatin Assembly and Disassembly; D004268:DNA-Binding Proteins / Q000502:physiology*; D006657:Histones / Q000502:physiology; D006801:Humans; D015398:Signal Transduction; D051785:Smad Proteins; D015534:Trans-Activators / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000502:physiology
D002843:Chromatin; D004268:DNA-Binding Proteins; D006657:Histones; D051785:Smad Proteins; D015534:Trans-Activators; D016212:Transforming Growth Factor beta