Acute regulation of the facilitative glucose transporter GLUT1 in a hematopoietic cell line.
This brief review is focused on the short-term regulation of the facilitative glucose transporter GLUT1 in megakaryocytic cells M07e. The effects of cytokines such as TPO, GM-CSF and SCF and of a low dose of H202 on the transport activity and its kinetic parameters are compared. The possible mechanisms and the signalling pathways involved in the glucose uptake activation are discussed. A role for the cellular redox status in glucose uptake control, possibly related to the status of redox-sensitive enzymes such as tyrosine phosphatases, is suggested.
Hakim
Gabriele
G
Dipartimento di Biochimica G. Moruzzi Università di Bologna, ITALY. gabriele.hakim@unibo.it
Fiorentini
Diana
D
Maraldi
Tullia
T
Landi
Laura
L
D016207:Cytokines / Q000494:pharmacology; D003847:Deoxyglucose / Q000378:metabolism; D005947:Glucose; D051272:Glucose Transporter Type 1; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D008533:Megakaryocytes / Q000187:drug effects / Q000378:metabolism; D009004:Monosaccharide Transport Proteins / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000502:physiology; D017382:Reactive Oxygen Species / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects
D016207:Cytokines; D051272:Glucose Transporter Type 1; D009004:Monosaccharide Transport Proteins; D017382:Reactive Oxygen Species; C495677:SLC2A1 protein, human; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D003847:Deoxyglucose; D006861:Hydrogen Peroxide; D011505:Protein-Tyrosine Kinases; D005947:Glucose