[The interplay of magnesium and vitamin K2 on bone mineralization].
Magnesium (Mg) is most likely restored in bone matrix, implicating a pivotal role in bone mineralization. Mg-insufficient bone reveals fragility to mechanical loading despite normal or higher levels of bone mineral content, permitting stimulated osteoclastic bone resorption. In contrast, vitamin K(2) (MK-4:menatetrenone) inhibited osteoclastic bone resorption stimulated by the Mg-insufficiency, thereby normalizing bone remodeling. The Mg-insufficiency caused an increased concentration of calcium, which resulted in an extremely-high purity of hydroxyapatite (HA) crystal [Ca(10)(PO(4))(6)(OH)(2)] and accelerated mineralization in bone. In contrast, MK-4 did not affect the calcium-concentration nor HA-purity, but repressed mineralization accelerated by Mg-insufficiency. Thus, MK-4 appears to recover the "bone quality" lessened by the Mg-insufficiency by two mechanisms:controlling bone turnover and mineralization.
Divisions of Oral Anatomy, Niigata University Graduate School of Medical and Dental Sciences Center for Transdisciplinary Research, Niigata University, Niigata, Japan.
Norio
N
Amizuka
Minqi
M
Li
Takeyasu
T
Maeda
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism; D002113:Calcification, Physiologic / Q000187:drug effects*; D008274:Magnesium / Q000494:pharmacology*; D051381:Rats; D024482:Vitamin K 2 / Q000494:pharmacology*
D024482:Vitamin K 2; D008274:Magnesium