PRISM: protein interactions by structural matching.
Prism (http://gordion.hpc.eng.ku.edu.tr/prism) is a website for protein interface analysis and prediction of putative protein-protein interactions. It is composed of a database holding protein interface structures derived from the Protein Data Bank (PDB). The server also includes summary information about related proteins and an interactive protein interface viewer. A list of putative protein-protein interactions obtained by running our prediction algorithm can also be accessed. These results are applied to a set of protein structures obtained from the PDB at the time of algorithm execution (January 2004). Users can browse through the non-redundant dataset of representative interfaces on which the prediction algorithm depends, retrieve the list of similar structures to these interfaces or see the results of interaction predictions for a particular protein. Another service provided is interactive prediction. This is done by running the algorithm for user input structures.
Ogmen
Utkan
U
Koc University, Center for Computational Biology and Bioinformatics and College of Engineering Rumelifeneri Yolu, Sariyer, Istanbul 34450, Turkey.
Keskin
Ozlem
O
Aytuna
A Selim
AS
Nussinov
Ruth
R
Gursoy
Attila
A
D000465:Algorithms; D020407:Internet; D011487:Protein Conformation; D025941:Protein Interaction Mapping / Q000379:methods*; D012984:Software; D014584:User-Computer Interface