Status of intracellular and extracellular magnesium concentration in patients with cardiac syndrome X.
OBJECTIVE
This study sought to clarify the differences of intracellular and extracellular magnesium levels in patients with cardiac syndrome X.


METHODS
We evaluated the intracellular and extracellular magnesium status of 22 patients with cardiac syndrome X (group A) and 22 age--and gender--matched disorder-free control subjects (group B). Levels of magnesium were determined in serum, urine, erythrocytes, and the 24-h magnesium retention rate was calculated by a magnesium loading test.


RESULTS
Group A showed a higher 24-h magnesium retention rate (49.8 +/- 1.3% vs. 32.6 +/- 7.5%, p < 0.05) and a lower intracellular concentration of magnesium in erythrocytes than group B (3.7 +/- 1.4 vs. 5.6 +/- 1.3 fg/cell, p < 0.05), demonstrating the presence of magnesium deficiency in group A. There were no significant differences in the serum concentration of magnesium between groups A and B (0.87 +/- 0.23 vs. 0.83 +/- 0.15 mmol/l).


CONCLUSIONS
This study demonstrated that the intracellular magnesium level decreased in patients with cardiac syndrome X.
Guo
Hangyuan
H
Department of Cardiology, Huayu Hospital, China Medical University, Shaoxing, Zhejiang, 312030, China. ghangyuan@hotmail.com
Lee
Jong-Dae
JD
Guo
Ming
M
Lu
Yong
Y
Tang
Fengqin
F
Ueda
Takanori
T
D000328:Adult; D004912:Erythrocytes / Q000737:chemistry*; D005260:Female; D006801:Humans; D008274:Magnesium / Q000097:blood / Q000378:metabolism* / Q000502:physiology / Q000652:urine; D008297:Male; D017566:Microvascular Angina / Q000097:blood / Q000378:metabolism* / Q000652:urine; D008875:Middle Aged
D008274:Magnesium