Granulocyte-colony stimulating factor-producing gallbladder cancer without recurrence more than 2 years after resection: report of a case.
Patients with gallbladder carcinoma rarely have remarkable granulocytosis. Although surgical resection is the most effective treatment, patients with gallbladder carcinoma generally have a very poor prognosis. We report a case of a rapidly growing gallbladder tumor associated with remarkable granulocytosis in a patient who has survived without recurrence for more than 2 years since undergoing resection. The patient had remarkable leukocytosis of 51,500/mm(3) with 89% granulocytes and an elevated granulocyte-colony stimulating factor (G-CSF) level of 800 pg/dl. We performed cholecystectomy with extended right lobectomy of the liver and lymph node dissection. A histological diagnosis of moderately differentiated gallbladder carcinoma with sarcomatous change invading the hepatic parenchyma was confirmed. An immunohistochemical examination using polyclonal antibody against G-CSF was performed to stain the tumor cells, which confirmed the diagnosis of a G-CSF-producing tumor.
Department of Surgery, Saiseikai Fukuoka General Hospital, Fukuoka, Japan.
Tetsuo
T
Ikeda
Kippei
K
Ohgaki
Masatoku
M
Miura
Shinichi
S
Aishima
Toshihisa
T
Shimizu
Yoshihiko
Y
Maehara
D000230:Adenocarcinoma / Q000378:metabolism* / Q000601:surgery; D002763:Cholecystectomy; D005260:Female; D005706:Gallbladder Neoplasms / Q000378:metabolism* / Q000601:surgery; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D006498:Hepatectomy; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local
D016179:Granulocyte Colony-Stimulating Factor