CO-trapping reaction under thermolysis of alkoxyamines: application to the synthesis of 3,4-cyclopenta-1-tetralones.
[reaction: see text] An efficient one-pot sequence comprising a PRE-mediated radical 5-exo-cyclization, a radical carbonylation, a nitroxide trapping reaction, and a subsequent acid-catalyzed Friedel-Craft-type acylation provides a new entry into 3,4-cyclopenta-1-tetralones. Eight examples are presented.
Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Japan.
Yoshitaka
Y
Uenoyama
Masaaki
M
Tsukida
Takashi
T
Doi
Ilhyong
I
Ryu
Armido
A
Studer