Phosphine oxides as preligands in ruthenium-catalyzed arylations via C-H bond functionalization using aryl chlorides.
[reaction: see text] The use of air-stable, electron-rich phosphine oxides as preligands allows for unprecedented general ruthenium-catalyzed arylation reactions of pyridines and imines through C-H-bond activation using aryl chlorides. The catalytic system derived from a sterically hindered adamantyl-substituted phosphine oxide proves highly efficient and tolerates a number of important functional groups.
Ackermann
Lutz
L
Department of Chemistry and Biochemistry, Ludwig-Maximilians-Universität München, Germany. Luiz.Ackermann@cup.uni-muenchen.de