Pneumocystis: not just pneumonia.
Once known exclusively as the agents of severe pneumonia in immunocompromised individuals, Pneumocystis spp. are now being associated with asymptomatic carriage in hosts that do not have profound immune debilitation. In the absence of a cultivation system, polymerase chain reaction and histological studies have identified Pneumocystis in neonatal populations, in pregnant women and in other patients that have chronic underlying disease processes. These findings in humans and in experimental animal models indicate the presence of potential reservoirs of infection, and provide insights into the transmission of this fungus. Also, the role of Pneumocystis has been investigated as a possible co-morbidity factor.
Department of Infectious Disease, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0560, USA.
J Chad
JC
Peterson
Melanie T
MT
Cushion
D000293:Adolescent; D000818:Animals; D002353:Carrier State / Q000382:microbiology*; D002648:Child; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000821:virology; D006801:Humans; D007223:Infant; D051379:Mice; D008807:Mice, Inbred BALB C; D016513:Mice, SCID; D011010:Pneumocystis / Q000302:isolation & purification*; D016720:Pneumocystis Infections / Q000382:microbiology*; D011020:Pneumonia, Pneumocystis / Q000382:microbiology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology; D051381:Rats