Effects of carvedilol upon intra- and interventricular synchrony in patients with chronic heart failure.
Radionuclide isotopic ventriculography with phase analysis was performed in 30 patients with stable heart failure (HF), determining left ventricular (LV) and interventricular contraction synchrony at baseline and after 6 months of treatment with maximal tolerated doses of carvedilol. Patients with HF had significant ventricular dyssynchrony compared with a normal population. The 50th percentile of patients with the greatest dyssynchrony at baseline showed significant improvement in ventricular synchrony after receiving carvedilol, and this was correlated positively with a reduction in end-diastolic LV volumes.
Castro
Pablo F
PF
Faculty of Medicine, P. Catholic University of Chile, University of Chile, Santiago, Chile. pcastro@med.puc.cl
Mc-Nab
Paul
P
Quintana
Juan Carlos
JC
Bittner
Alex
A
Greig
Douglas
D
Vergara
Ismael
I
Vukasovic
José Luis
JL
Corbalan
Ramón
R
Copaja
Miguel
M
Díaz-Araya
Guillermo
G
Chiong
Mario
M
Troncoso
Rodrigo
R
Alcaino
Hernán
H
Lavandero
Sergio
S
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D002227:Carbazoles / Q000008:administration & dosage*; D000077261:Carvedilol; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004562:Electrocardiography; D005260:Female; D006333:Heart Failure / Q000175:diagnosis* / Q000188:drug therapy* / Q000401:mortality; D006334:Heart Function Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011412:Propanolamines / Q000008:administration & dosage*; D011446:Prospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D015996:Survival Rate; D016896:Treatment Outcome; D016277:Ventricular Function, Left / Q000187:drug effects; D020257:Ventricular Remodeling / Q000187:drug effects*
D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D011412:Propanolamines; D000077261:Carvedilol