[Expression and clinical significance of p27 protein and cyclinD1 protein in gastrointestinal stromal tumors].
OBJECTIVE
To investigate the expression of p27 and cyclin D1 protein in gastrointestinal stromal tumors (GIST), and discuss the relationship between their expression and clincopathological characteristics.


METHODS
Immunohistochemical staining was used to detect the expression of p27 and cyclin D1 in 48 cases of GIST and corresponding normal tissues.


RESULTS
In 48 cases GIST, the expression of p27 and cyclin D1 protein were 54.16% and 58.33% respectively. The low level expression of p27 protein was inversely correlated with the degree of differentiation and tumor recurrence of GIST (both P < 0.01). The expression of p27 protein was positively relatied to that of cyclin D1 (r = 0.573, P < 0.01).


CONCLUSIONS
These data shows the expression of p27 and cyclin D1 expression are related to the ontogenesis and progression of GIST. p27 and cyclin D1 may be prognostic indicators in GIST.
Yang
Xiong-dong
XD
Department of Gastrointestinal Surgery, Shengzhen People's Hospital, Jinan University Medical College, Shengzhen 518020, China.
Zuo
Min
M
Pan
Kai
K
D019938:Cyclin D1 / Q000096:biosynthesis* / Q000235:genetics; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D047428:Protein Kinase Inhibitors
D047428:Protein Kinase Inhibitors; D019938:Cyclin D1; D050760:Cyclin-Dependent Kinase Inhibitor p27