[Expression of Survivin and Bcl-2 in laryngeal squamous cell carcinoma and their significance].
OBJECTIVE
To research the expression of Survivin and Bcl-2 protein in laryngeal squamous cell carcinoma (LSCC) and the correlation between them.


METHODS
Immunohistochemical (SP) method was used to detect the expression of Survivin and Bcl-2 in 64 cases of LSCC, 28 cases of normal laryngeal mucous membrane and 20 cases of laryngeal benign lesion. The relationship among them was studied by statistical analysis.


RESULTS
Survivin protein was expressed in 43 of 64 (67.2%) samples of LSCC, just 2 samples was expressed in laryngeal benign lesion (10%) and 1 sample expressed in normal laryngeal mucosa (3.6%). The over expression of Survivin was related to the tumor's location, clinical stage, histological grade, lymphatic metastasis. The expression of Survivin was correlated with the expression of Bcl-2.


CONCLUSIONS
Survivin may play an important role in the pathway of carcinogenesis, progress and metastasis of LSCC,it is feasible for early diagnosis and precaution. Bcl-2 and Survivin may play synergetic roles in the pathogenesis of LSCC.
Wang
Jizhe
J
Department of Otorhinolaryngology, the First Affiliated Hospital of China Medical University, Shenyang, 110001, China. wangjizhe2004@sina.com
Guan
Chao
C
Wang
Shouchen
S
Chen
Bin
B
Sun
Jialiang
J
Ji
Wenyue
W
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008869:Microtubule-Associated Proteins / Q000096:biosynthesis*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D000077022:Survivin
C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D000077022:Survivin