title: Acyclic amino acid-catalyzed direct asymmetric aldol reactions: alanine, the simplest stereoselective organocatalyst.
abstract: The linear amino acid-catalyzed direct asymmetric intermolecular aldol reaction is presented; simple amino acids such as alanine, valine, isoleucine, aspartate, alanine tetrazole and serine catalyzed the direct catalytic asymmetric intermolecular aldol reactions between unmodified ketones and aldehydes with excellent stereocontrol and furnished the corresponding aldol products in up to 98% yield and with up to > 99% ee.
authors: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Sweden. acordova1a@netscape.net
authors: Armando
authors: A
authors: Córdova
authors: Weibiao
authors: W
authors: Zou
authors: Ismail
authors: I
authors: Ibrahem
authors: Efraim
authors: E
authors: Reyes
authors: Magnus
authors: M
authors: Engqvist
authors: Wei-Wei
authors: WW
authors: Liao
mesh_terms: D000409:Alanine / Q000737:chemistry*; D000438:Alcohols; D000447:Aldehydes; D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D000447:Aldehydes; D000596:Amino Acids; D000409:Alanine