Improved quantitative dynamic regional oxygen-enhanced pulmonary imaging using image registration.
Oxygen-enhanced MR imaging has been demonstrated in a number of recent studies as a potential method to visualize regional ventilation in the lung. A quantitative pixel-by-pixel analysis is hampered by motion and volume change due to breathing. In this study, image registration via active shape modeling is shown to produce significant improvements in the regional analysis of both static and dynamic oxygen-enhanced pulmonary MRI for five normal volunteers. The method enables the calculation of regional change in relaxation rate between breathing air and 100% oxygen, which is proportional to the change in regional oxygen concentration, and regional oxygen wash-in and wash-out time constants. Registration-corrected mapping of these parameters is likely to provide improved information in the regional assessment of a range of lung diseases.
Naish
Josephine H
JH
Imaging Science and Biomedical Engineering, University of Manchester, Manchester, United Kingdom. Josephine.naish@manchester.ac.uk
Parker
Geoffrey J M
GJ
Beatty
Paul C
PC
Jackson
Alan
A
Young
Simon S
SS
Waterton
John C
JC
Taylor
Chris J
CJ
D000280:Administration, Inhalation; D000328:Adult; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008168:Lung / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010100:Oxygen / Q000008:administration & dosage*; D011659:Pulmonary Gas Exchange / Q000502:physiology; D012680:Sensitivity and Specificity
D010100:Oxygen