Systematic review: proton-pump inhibitor failure in gastro-oesophageal reflux disease--where next?
Proton-pump inhibitor failure has become a common clinical dilemma in gastrointestinal clinics and has been increasingly encountered at the primary care level as well. Underlying mechanisms are diverse and may overlap. Most patients who have proton-pump inhibitor failure are likely to originate from the non-erosive reflux disease phenotype. Currently, available diagnostic modalities provide limited clues to the exact underlying cause. Treatment relies primarily on escalating dosing of proton-pump inhibitors. However, new insights into the pathophysiology of proton-pump inhibitor failure are likely to provide alternative therapeutic options.
Fass
R
R
The Neuro-Enteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona, School of Medicine, Tucson, AZ, USA. ronnie.fass@med.va.gov
Shapiro
M
M
Dekel
R
R
Sewell
J
J
D001682:Biological Availability; D004941:Esophagitis / Q000188:drug therapy; D005746:Gastric Emptying / Q000187:drug effects; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D016481:Helicobacter Infections / Q000150:complications; D016480:Helicobacter pylori; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology; D001523:Mental Disorders / Q000150:complications; D010349:Patient Compliance; D054328:Proton Pump Inhibitors
D054328:Proton Pump Inhibitors