title: Candidates for tumor-specific alternative splicing.
abstract: Gene expression can be regulated not only by transcription and post-transcriptional modifications, but also by splicing regulation. Recent genome-wide analyses have indicated that up to 70% of human genes may have alternatively spliced forms, suggesting that splicing regulation affects a wide range of gene expression. Tumor tissues show significantly altered protein expressions, and this is also thought to be affected by alternative splicing. Although some alternative splicing events have been reported to be cancer specific and others have been predicted from database analyses, the process of alternative splicing and its regulatory machinery are hardly understood. We searched for and detected alternative splicing events that alter protein splicing in all or a subset of tumor tissues. The results revealed tissue-specific alterations of splicing regulation by tumorigenesis, and regulatory cis-element analyses further suggested that multiple splicing regulatory machineries were affected by this process.
authors: Division of Structural Cellular Biology, The Graduate School of Biological Sciences, Nara Institute of Science and Technology (NAIST), 8916-5 Takayama, Ikoma, Nara 630-0101, Japan. masayo@bs.naist.jp
authors: Masayo
authors: M
authors: Okumura
authors: Shinichi
authors: S
authors: Kondo
authors: Maiko
authors: M
authors: Ogata
authors: Soshi
authors: S
authors: Kanemoto
authors: Tomohiko
authors: T
authors: Murakami
authors: Kanta
authors: K
authors: Yanagida
authors: Atsushi
authors: A
authors: Saito
authors: Kazunori
authors: K
authors: Imaizumi
mesh_terms: D017398:Alternative Splicing / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism*; D002277:Carcinoma / Q000235:genetics* / Q000378:metabolism*; D045744:Cell Line, Tumor; D002874:Chromosome Mapping; D005091:Exons; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism*; D017422:Sequence Analysis, DNA
chemical_list: D014408:Biomarkers, Tumor; D005819:Genetic Markers; D009363:Neoplasm Proteins