title: [Inclusion constant of beta-CD and paeonol measured by phase solubility method].
abstract: OBJECTIVE
  Measure the thermal stability and the forming constant of inclusion complex for paeonol with beta-CD, and investigate interaction between beta-CD and paeonol,
  
  
  METHODS
  The thermal stability investigated by using different thermal analysis. The forming constant was determined by using phase method.
  
  
  RESULTS
  Comparing with melt temperature of paeonol, that of its inclusion complex increase about 220 degrees C. The solubility of paeonol increases with the increased concentration of beta-CD, the composing ratio and the inclusion constant of beta-CD-paeonol is respectively 1/1 and 27.42 mL x mg(-1).
  
  
  CONCLUSIONS
  Inclusion constant is applied to research the stability of included drug in physiological condition.
authors: Henan College of Traditional Chinese Medicine, Zhengzhou 450008, China. wxf@hactcm.edu.cn
authors: Xue-fen
authors: XF
authors: Wu
authors: Xiao-ke
authors: XK
authors: Zheng
authors: Hong-jian
authors: HJ
authors: Yao
authors: Na
authors: N
authors: Fei
mesh_terms: D000098:Acetophenones / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification; D004337:Drug Carriers; D004347:Drug Interactions; D004355:Drug Stability; D006358:Hot Temperature; D029596:Paeonia / Q000737:chemistry; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D012995:Solubility; D047392:beta-Cyclodextrins
chemical_list: D000098:Acetophenones; D004337:Drug Carriers; D047392:beta-Cyclodextrins; C013638:paeonol