Cost-effectiveness of endovascular abdominal aortic aneurysm repair.
BACKGROUND
The rapid introduction of endovascular abdominal aortic aneurysm repair (EVAR) has considerable implications for the management of abdominal aortic aneurysm (AAA). This study was undertaken to determine an optimal strategy for the use of EVAR based on the best currently available evidence.


METHODS
Economic modelling and probabilistic sensitivity analysis considered reference cases representing a fit 70-year-old with a 5.5-cm diameter AAA (RC1) and an 80-year-old with a 6.5-cm AAA unfit for open surgery (RC2). Results were assessed as incremental cost-effectiveness ratio (ICER) compared with open repair (RC1) or conservative management (RC2).


RESULTS
In RC1 EVAR produced a gain of 0.10 quality-adjusted life years (QALYs) for an estimated cost of 11,449 pound, giving an ICER of 110,000 pound per QALY. EVAR consistently had an ICER above 30,000 pound per QALY over a range of sensitivity analyses and alternative scenarios. In RC2 EVAR produced an estimated benefit of 1.64 QALYs for an incremental cost of 14,077 pound giving an incremental cost per QALY of 8579 pound.


CONCLUSIONS
: It is unlikely that EVAR for fit patients suitable for open repair is within the commonly accepted range of cost-effectiveness for a new technology. For those unfit for conventional open repair it is likely to be a cost-effective alternative to non-operative management. Sensitivity analysis suggests that research efforts should concentrate on determining accurate rates for late complications and reintervention, particularly in patients with high operative risks.
Michaels
J A
JA
Academic Vascular Unit, Coleridge House, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK. j.michaels@sheffield.ac.uk
Drury
D
D
Thomas
S M
SM
D000368:Aged; D000369:Aged, 80 and over; D017130:Angioplasty / Q000191:economics* / Q000379:methods; D017544:Aortic Aneurysm, Abdominal / Q000191:economics* / Q000601:surgery; D003362:Cost-Benefit Analysis; D006801:Humans; D018803:Models, Economic; D019057:Quality-Adjusted Life Years; D016032:Randomized Controlled Trials as Topic