How does DNA compaction favor chiral selectivity with cationic species? Higher selectivity with lower cationic charge.
A single-molecule study on giant DNA compaction by enantiomeric dications and tetracations demonstrates that strong chiral discrimination in DNA compaction is manifested only if the positive charge on enantiomeric multications is relatively low. The increase in cationicity of the chiral compaction agent inevitably leads to an increase in nonspecific electrostatic interactions and quenching of chiral discrimination in the DNA-folding phase transition.
Zinchenko
Anatoly A
AA
Department of Physics, Graduate School of Science, Kyoto University, Sakyo, Kyoto, 608-8501, Japan. zinchenko@chem.scphys.kyoto-u.ac.jp
Chen
Ning
N
Murata
Shizuaki
S
Yoshikawa
Kenichi
K
D017122:Bacteriophage T4 / Q000737:chemistry; D002412:Cations / Q000737:chemistry; D004247:DNA / Q000737:chemistry* / Q000378:metabolism* / Q000648:ultrastructure; D004279:DNA, Viral / Q000737:chemistry / Q000378:metabolism*; D008856:Microscopy, Fluorescence; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D055672:Static Electricity; D013237:Stereoisomerism
D002412:Cations; D004279:DNA, Viral; D004247:DNA