[Evaluation of cerebral oxygen balance during normothermic cardiopulmonary bypass using jugular oxygen saturation].
BACKGROUND
Previous studies suggest that normothermic cardiopulmonary bypass(CPB) impairs cerebral oxygen balance. We studied the effect of normothermic CPB on cerebral oxygen balance evaluated by continuous measurement of oxygen saturation in the jugular vein (SjO2).


METHODS
Eleven patients undergoing coronary artery bypass grafting with normothermic CPB were studied. A 4 Fr oxymetry catheter was inserted into the internal jugular bulb for SjO2 monitoring. We measured mean arterial pressure (MAP), SjO2 and hemoglobin (Hgb) concentration at five time points-1) pre CPB, 2) 3) 4) 5, 30, 60 min after the onset of CPB, respectively, 5) 5 min after the end of CPB.


RESULTS
MAP decreased significantly 30 min (47 +/- 9 mmHg) and 60 min (48 +/- 9 mmHg) after the onset of CPB compared with the pre CPB (80 +/- 14 mmHg) value. Hgb also decreased significantly 5 min (7.8 +/- 1.1 g x dl(-1)) and 30 min (7.1 +/- 1.0 g x dl(-1)) and 60 min (7.1 +/- 0.8 g x dl(-1)) after the onset of CPB compared with the pre CPB (11 +/- 1.0 g x dl(-1)) value. However, SjO2 showed no significant change throughout the study period. No significant correlation was observed between MAP and SjO2.


CONCLUSIONS
Cerebral oxygen balance assessed by SjO2 was not impaired during normothermic CPB, and was unaffected by hypotension and hemodilution.
Uesugi
Fumihiko
F
Department of Anesthesia, Chugoku Rosai General Hospital, Kure.
Nakagawa
Itsuo
I
Hidaka
Shozo
S
Kubo
Takashi
T
Okamura
Kenta
K
Kato
Takahiro
T
D000368:Aged; D001921:Brain / Q000378:metabolism*; D002315:Cardiopulmonary Bypass; D006801:Humans; D007601:Jugular Veins; D010100:Oxygen / Q000097:blood / Q000378:metabolism*
D010100:Oxygen