title: ABO/secretor genetic complex is associated with the susceptibility of childhood asthma in Taiwan.
abstract: BACKGROUND
  Histo-blood groups, ABO, Lewis (Le) and secretor (Se) were found to be associated with lower lung function and wheezing in coal miners as well as in asthmatic children in some studies but not others, possibly reflecting the genetic heterogeneity among different ethnicities and local environmental exposure.
  
  
  OBJECTIVE
  The present study was conducted to determine the association between ABO, Lewis and secretor genetic complex with susceptibility of childhood asthma in Taiwan.
  
  
  METHODS
  We randomly selected 136 asthmatic children and 161 age-matched controls from a childhood asthma survey conducted in primary schools. ABO and Lewis blood groups were determined by red blood cell agglutination methods. Analysis of Se genotype was performed by PCR with sequence-specific primers.
  
  
  RESULTS
  There was a higher prevalence rate in secretor subjects (Se/Se) (odds ratio (OR)=1.7, confidence interval (CI)=1.022-2.938) in asthma as compared with controls. The combined effect of these three blood systems revealed that blood group O/secretor phenotype (Se/Se) (OR=2.7, CI=1.126-6.033), and blood group O/Le(a-b-) (OR=3.6, CI=1.080-11.963, P<0.03) individuals were significantly associated with asthma. The Lewis Le(a-b-) recessive genotype (OR=3.3, CI=1.267-8.482), or the joint blood group O/Le(a-b-) phenotype (OR=5.2, CI=1.259-21.429, P<0.02), was significantly associated with high serum IgE (>500 IU), respectively. There was no association of these three blood systems with the sensitivity of dust mite, Dermatophagoide pteronyssinus, in our study population.
  
  
  CONCLUSIONS
  We concluded that blood group O/secretors (Se/Se) and O/Le(a-b-) were associated with childhood asthma, and may act as one of the predominant factors for environmental triggers of allergy for asthmatic children in Taiwan.
authors: Laboratory of Molecular Diagnostics, Department of Clinical Pathology, Chi-Mei Hospital, Tainan, Taiwan.
authors: Y-L
authors: YL
authors: Chen
authors: J-C
authors: JC
authors: Chen
authors: T-M
authors: TM
authors: Lin
authors: T-J
authors: TJ
authors: Huang
authors: S-T
authors: ST
authors: Wang
authors: M-F
authors: MF
authors: Lee
authors: J-Y
authors: JY
authors: Wang
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics*; D000293:Adolescent; D000485:Allergens / Q000276:immunology; D001249:Asthma / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D002648:Child; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D005838:Genotype; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007983:Lewis Blood Group Antigens / Q000235:genetics*; D008297:Male; D021141:Nucleic Acid Amplification Techniques / Q000379:methods; D010641:Phenotype; D016133:Polymerase Chain Reaction / Q000379:methods; D015995:Prevalence; D013624:Taiwan / Q000453:epidemiology
chemical_list: D000017:ABO Blood-Group System; D000485:Allergens; D007983:Lewis Blood Group Antigens; D007073:Immunoglobulin E