title: Identification of a novel protein for memory regulation in the hippocampus.
abstract: Memory formation, maintenance, and retrieval are a dynamic process, reflecting a combined outcome of new memory formation on one hand, and older memory suppression/clearance on the other. Although much knowledge has been gained regarding new memory formation, less is known about the molecular components and processes that serve the function of memory suppression/clearance. Here, we report the identification of a novel protein, termed hippyragranin (HGN), that is expressed in the rat hippocampus and its expression is reduced by hippocampal denervation. Inhibition of HGN by antisense oligonucleotide in area CA1 results in enhanced performance in Morris water maze, as well as elevated long-term potentiation. These results suggest that HGN is involved in negative memory regulation.
authors: Laboratory of Higher Brain Functions, Institute of Neurobiology, Fudan University, Shanghai 200433, China.
authors: Xue-Han
authors: XH
authors: Zhang
authors: Hui
authors: H
authors: Zhang
authors: Yanyang
authors: Y
authors: Tu
authors: Xiang
authors: X
authors: Gao
authors: Changfu
authors: C
authors: Zhou
authors: Meilei
authors: M
authors: Jin
authors: Guoping
authors: G
authors: Zhao
authors: Naihe
authors: N
authors: Jing
authors: Bao-Ming
authors: BM
authors: Li
authors: Lei
authors: L
authors: Yu
mesh_terms: D000818:Animals; D001483:Base Sequence; D015536:Down-Regulation / Q000502:physiology; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000378:metabolism; D017774:Long-Term Potentiation / Q000502:physiology; D018782:Maze Learning / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D009419:Nerve Tissue Proteins