Psychotropic effects of sidnocarb and ladasten in inbred mice with different reaction to emotional stress.
Dose-dependent relationship of the effects of sidnocarb and Ladasten on open field behavior and free motor activity was studied in inbred C57Bl/6 and BALB/c mice differing by emotional stress reaction phenotype. Ladasten in a dose of 10 mg/kg produced activating and anxiolytic effects on BALB/c mice in the open field test. Combined injection of Ladasten (10 mg/kg) and sidnocarb (6 or 12 mg/kg) activated animal behavior in both tests.
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V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.
D000218:Adamantane / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011619:Psychotropic Drugs / Q000494:pharmacology*; D013315:Stress, Psychological / Q000235:genetics / Q000503:physiopathology*; D013558:Sydnones / Q000494:pharmacology*
C493151:N-(2-adamantyl)-N-p-bromophenylamine; D011619:Psychotropic Drugs; D013558:Sydnones; D000218:Adamantane; C009257:sidnocarb