Local production of interleukins and growth factors in external genital endometriosis.
Secretion of some IL and growth factors (VEGF, IGF-I, TGFbeta) by endometrial tissues and endometrioid heterotopies was studied in vitro in patients with external genital endometriosis of different severity. The production of IL-1beta, IL-2, IL-6, and VEGF in the endometrium increased in severe external genital endometriosis, while the secretion of TGFbeta decreased; hyperproduction of IL-2, IL-6, VEGF and decreased production of TGFbeta were detected in endometrioid foci. Presumably, local cytokine imbalance and increased proliferative activity of endometrial cells are involved in the mechanisms of formation and functioning of endometrioid foci.
Sel'kov
S A
SA
D. O. Ott Institute of Obstetrics and gynecology, Russian Academy of Medical Sciences, St. Petersburg, Russia.
Solodovnikova
N G
NG
Pavlov
O V
OV
Niauri
D A
DA
D000328:Adult; D004715:Endometriosis / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006133:Growth Substances / Q000096:biosynthesis*; D006801:Humans; D007378:Interleukins / Q000096:biosynthesis*; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis
D006133:Growth Substances; D007378:Interleukins; D042461:Vascular Endothelial Growth Factor A