title: Analyzing the radiation of the melanocortins in amphibians: cloning of POMC cDNAs from the pituitary of the urodele amphibians, Amphiuma means and Necturus maculosus.
abstract: Proopiomelanocortin (POMC) cDNAs were cloned and sequenced from brain extracts of two species of urodele amphibians: Amphiuma means and Necturus maculosus. Although the two species of urodele amphibians belong to separate families, and do not share a direct common ancestor, the level of primary sequence identity for the open reading of the POMC cDNAs was 90% at the amino acid level and 79% at the nucleotide level. It appears that the POMC gene in these urodele amphibians has been accumulating mutations at the amino acid level at a slower rate than the POMC gene in other sarcopterygian orders.
authors: University of Denver, Department of Biological Sciences, Denver, CO 80210, USA.
authors: Katarzyna
authors: K
authors: Kozak
authors: David
authors: D
authors: Costantino
authors: Stephanie
authors: S
authors: Lecaude
authors: Cristina
authors: C
authors: Sollars
authors: Phillip
authors: P
authors: Danielson
authors: Robert M
authors: RM
authors: Dores
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D019143:Evolution, Molecular; D005260:Female; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009338:Necturus maculosus / Q000235:genetics*; D010902:Pituitary Gland / Q000378:metabolism / Q000528:radiation effects; D011333:Pro-Opiomelanocortin / Q000235:genetics* / Q000378:metabolism / Q000528:radiation effects*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D020539:Sequence Analysis, Protein; D014562:Caudata / Q000235:genetics*; D019825:gamma-MSH / Q000235:genetics / Q000528:radiation effects
chemical_list: D019825:gamma-MSH; D011333:Pro-Opiomelanocortin