Phosphorylation of alcohols with N-phosphoryl oxazolidinones employing copper(II) triflate catalysis.
[reaction: see text]. Phosphoryl transfer from N-phosphoryl 5,5-diphenyl oxazolidinone is efficiently catalyzed by copper(II) triflate. The utility of this method has been demonstrated in the phosphorylation of representative primary, secondary, tertiary, phenolic, and allylic alcohols. These reaction conditions are significantly milder than employing alkoxides and allow the phosphorylation of biologically relevant molecules.
Jones
Simon
S
Department of Chemistry, University of Sheffield, Dainton Building, Brook Hill, UK. simon.jones@sheffield.ac.uk
Smanmoo
Chaiwat
C