Mild and efficient removal of hydroxyethyl unit from 2-hydroxyethyl ether derivatives leading to alcohols.
[reaction: see text]. CAN is a good reagent for the transformation of 2-hydroxyethyl ether units to alcohols. Significantly, many functional groups can tolerate the reaction conditions, although they do not survive under many previously reported removal conditions. The reaction mechanism is clarified.
Fujioka
Hiromichi
H
Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan. fujioka@phs.osaka-u.ac.jp
Ohba
Yusuke
Y
Hirose
Hideki
H
Murai
Kenichi
K
Kita
Yasuyuki
Y