Prooxidant-antioxidant balance in the prostate and blood of rats with sulpyride[corrected]-induced prostatic hyperplasia corrected with prostatilen.
We studied the effects of 30-day injections of sulpyride and treatment with Prostatilen on the development of prostatic hyperplasia and LPO in rats. Sulpyride induced proliferation of lateral lobes, increased the content of lipid hydroperoxides and glutathione peroxidase activity in the gland; in the blood this preparation increased lipid hydroperoxide concentration and decreased glutathione peroxidase and total antioxidant activity. Prostatilen prevented the development of hyperplasia and normalized the prooxidant-antioxidant balance in tissues, except total antioxidant activity of the blood.
Belostotskaya
L I
LI
Laboratory of General Pharmacology, Drug Research Center, V. N. Karazin Kharkov National University, Kharkov. lubilost@ukr.net
Gomon
O N
ON
Nikitchenko
Yu V
YV
Chaika
L A
LA
Bondar
V V
VV
Dzyuba
V N
VN
D000818:Animals; D005979:Glutathione Peroxidase / Q000097:blood / Q000378:metabolism; D008054:Lipid Peroxides / Q000097:blood / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D010455:Peptides / Q000627:therapeutic use*; D011470:Prostatic Hyperplasia / Q000097:blood* / Q000139:chemically induced / Q000201:enzymology / Q000378:metabolism* / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D013469:Sulpiride
D008054:Lipid Peroxides; D010455:Peptides; C069549:prostatilen; D013469:Sulpiride; D005979:Glutathione Peroxidase