Kadsuphilactones A and B, two new triterpene dilactones from kadsuraphilippinensis.
[structure: see text]. Two novel triterpene dilactones, kadsuphilactones A (1) and B (2), were isolated from the Taiwanese medicinal plant Kadsura philippinensis. The structures of 1 and 2 were elucidated on the basis of extensive spectroscopic methods, including two-dimensional NMR techniques, and confirmed by X-ray crystallographic analysis. Kadsuphilactone B (2) exhibited in vitro anti-HBV activity with IC(50) values of 6 microg/mL by HBsAg enzyme immunoassay.
Shen
Ya-Ching
YC
Department of Marine Resources, National Sun Yat-Sen University, Taiwan, Republic of China. ycshen@mail.nsysu.edu.tw
Lin
Yu-Chi
YC
Chiang
Michael Y
MY
Yeh
Sheau Farn
SF
Cheng
Yuan-Bin
YB
Liao
Chia-Ching
CC
D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D006515:Hepatitis B virus / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D032135:Kadsura / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000998:Antiviral Agents; D007783:Lactones; D014315:Triterpenes; C510337:kadsuphilactone A; C510338:kadsuphilactone B