title: Sensitive and fast T1 mapping based on two inversion recovery images and a reference image.
abstract: We developed a fast method to obtain T1 relaxation maps in magnetic resonance imaging (MRI) based on two inversion recovery acquisitions and a reference acquisition, while maintaining high sensitivity by utilizing the full dynamic range of the MRI signal. Optimal inversion times for estimating T1 in the human brain were predicted using standard error propagation theory. In vivo measurements on nine healthy volunteers yielded T1 values of 1094+/-18 ms in gray matter and 746+/-40 ms in white matter, in reasonable agreement with literature values using conventional approaches. The proposed method should be useful for clinical studies because the T1 maps can be obtained within a few seconds.
authors: University of California-San Francisco, 4150 Clement Street, 114M San Francisco, California 94121, USA. ghjahng@itsa.ucsf.edu
authors: Geon-Ho
authors: GH
authors: Jahng
authors: Lara
authors: L
authors: Stables
authors: Andreas
authors: A
authors: Ebel
authors: Gerald B
authors: GB
authors: Matson
authors: Dieter J
authors: DJ
authors: Meyerhoff
authors: Michael W
authors: MW
authors: Weiner
authors: Norbert
authors: N
authors: Schuff
mesh_terms: D000465:Algorithms; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015233:Models, Statistical; D011859:Radiography; D012680:Sensitivity and Specificity