title: [Antidepressant amides from Piper laetispicum C. DC].
abstract: OBJECTIVE
  To investigate the antidepressant constituents of Piper laetispicum C. DC.
  
  
  METHODS
  The compounds were enriched by column chromatography on silica gel. Structural determination of the pure compounds was based on extensive analyses of modern spectroscopic methods including MS, HR-MS, UV, IR, 1D- and 2D-NMR spectra. The mouse forced swimming test was used for chasing antidepressant activity.
  
  
  RESULTS
  Three amides were isolated and identified as N-isobutyl-(3,4-methylendioxyphenyl)-2E, 4E, 9E-undecatrienoamide (I), N-isobutyl-9-phenyl-2E, 4E-nonadienamide (II) and N-isobutyl-7-phenyl-2E, 4E-heptadienamide (III).
  
  
  CONCLUSIONS
  N-Isobutyl-(3,4-methylendioxyphenyl)-2E, 4E, 9E-undecatrienoamide (I) is a new compound named as laetispicine. N-Isobutyl-9-phenyl-2E, 4E-nonadienamide (II) and N-isobutyl-7-phenyl-2E, 4E-heptadienamide (III) were isolated for the first time as natural substance.
authors: School of Pharmacy, Fudan University, Shanghai 200032, China. panshengli@online.sh.cn
authors: Sheng-li
authors: SL
authors: Pan
authors: Jing
authors: J
authors: Xie
authors: Fu-gang
authors: FG
authors: Qian
authors: Jun
authors: J
authors: Wang
authors: Yi-ci
authors: YC
authors: Shao
mesh_terms: D000928:Antidepressive Agents / Q000737:chemistry / Q000302:isolation & purification*; D052117:Benzodioxoles / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D031701:Piper / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000928:Antidepressive Agents; D052117:Benzodioxoles; C512035:N-isobutyl-(3,4-methylenedioxyphenyl)-2,4,9-undecatrienoamide