title: A model of muscle atrophy using cast immobilization in mice.
abstract: We describe a new cast-immobilization protocol to induce muscle atrophy in the lower hindlimb muscles of mice. Bilateral cast immobilization for 2 weeks in a shortened position resulted in a significant loss of muscle size and strength in the soleus and extensor digitorum longus. The availability of a model of cast immobilization in mice may benefit future studies targeting genetic or cell therapy interventions of muscle atrophy in transgenic and mutant mice strains.
authors: Brain Rehabilitation Research Center, Malcom Randall Department of Veterans Affairs Medical Center, Gainesville, Florida, USA.
authors: Tiffany N
authors: TN
authors: Frimel
authors: Fatema
authors: F
authors: Kapadia
authors: Gabriel S
authors: GS
authors: Gaidosh
authors: Ye
authors: Y
authors: Li
authors: Glenn A
authors: GA
authors: Walter
authors: Krista
authors: K
authors: Vandenborne
mesh_terms: D000818:Animals; D005260:Female; D019417:Hindlimb Suspension / Q000009:adverse effects; D051379:Mice; D008810:Mice, Inbred C57BL; D023421:Models, Animal; D009133:Muscular Atrophy / Q000209:etiology / Q000503:physiopathology*