Novel expression patterns of Pax3/Pax7 in early trunk neural crest and its melanocyte and non-melanocyte lineages in amniote embryos.
Neural crest cells are considered a key vertebrate feature that is studied intensively because of their relevance to development and evolution. Here we report the expression of Pax7 in the dorsal non-neural ectoderm and in the trunk neural crest of the early chick embryo. Pax7 is expressed in the trunk neural crest migrating along the ventral and dorsolateral routes. Pax7 is first downregulated in the neural crest-derived neuronal precursors, secondly in the glial, and finally in the melanocyte precursors. Conserved developmental expression in the melanocyte lineage of both Pax3 and Pax7 was evidenced in chick and quail, but only Pax3 in mouse and rat.
Lacosta
Ana M
AM
Laboratory of Neurobiology, Department of Anatomy, Embryology and Animal Genetics, Faculty of Veterinary, Miguel Servet 177, E-50013, University of Zaragoza, Zaragoza, Spain.
Muniesa
Pedro
P
Ruberte
Jesús
J
Sarasa
Manuel
M
Domínguez
Luis
L
D000818:Animals; D019521:Body Patterning; D019070:Cell Lineage; D002465:Cell Movement; D002642:Chick Embryo; D015536:Down-Regulation; D008544:Melanocytes / Q000166:cytology / Q000502:physiology; D051379:Mice; D009432:Neural Crest / Q000166:cytology / Q000196:embryology / Q000378:metabolism*; D051761:Paired Box Transcription Factors / Q000096:biosynthesis*; D011784:Quail; D051381:Rats; D017208:Rats, Wistar
D051761:Paired Box Transcription Factors