Genomic medicine: bringing biomarkers to clinical medicine.
An important by-product of sequencing the human genome has been the development of a novel 'toolbox' for biomarker discovery and development. Genomic medicine is an emerging discipline in the genome sciences that integrates these tools to interrogate genomic variation in well-defined populations in order to develop predictors of disease susceptibility, progression and drug response. Several important classes of biomarkers result from these analyses which, when translated to clinical medicine and drug development, will have an important impact on human health and disease. This review highlights both the opportunities and challenges in bringing biomarkers into clinical medicine.
Seo
David
D
Center for Genomic Medicine, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA.
Ginsburg
Geoffrey S
GS
D015510:Clinical Medicine / Q000379:methods* / Q000639:trends*; D005819:Genetic Markers; D023281:Genomics / Q000639:trends*; D006801:Humans; D010597:Pharmacogenetics / Q000639:trends
D005819:Genetic Markers