title: Heritability of psychosis in Alzheimer disease.
abstract: OBJECTIVE
  The authors have previously demonstrated familial clustering of psychotic symptoms in late-onset Alzheimer disease (LOAD+P) and sought to estimate and explore the nature of the heritability of LOAD+P.
  
  
  METHODS
  The heritability of LOAD+P, defined by single and multiple psychotic symptoms, was estimated with data from the National Institute of Mental Health AD Genetics Initiative.
  
  
  RESULTS
  The estimated heritability for LOAD+P defined by multiple psychotic symptoms was 61%; for LOAD+P defined by any occurrence of psychotic symptoms, it was 30%.
  
  
  CONCLUSIONS
  Multiplicity of symptoms may represent a useful means for defining a genetically determined LOAD+P phenotype.
authors: Dept. of Psychiatry, Univ. of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213, USA.
authors: Silviu-Alin
authors: SA
authors: Bacanu
authors: Bernie
authors: B
authors: Devlin
authors: Kodavali V
authors: KV
authors: Chowdari
authors: Steven T
authors: ST
authors: DeKosky
authors: Vishwajit L
authors: VL
authors: Nimgaonkar
authors: Robert A
authors: RA
authors: Sweet
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications*; D016000:Cluster Analysis; D005500:Follow-Up Studies; D008040:Genetic Linkage / Q000235:genetics; D006801:Humans; D010641:Phenotype; D011618:Psychotic Disorders / Q000150:complications* / Q000453:epidemiology / Q000235:genetics*