Effect of IFN-alpha on CC1 4-induced fibrosis of the liver and immune status in mice of different age.
In young, adult, and old mice fibrosis was induced by administration of CC1(4) and treated with IFN-alpha; liver fibrosis was evaluated by morphometry of argyrophilic fibers, immune status by the splenocyte proliferative response. minimum immunosuppression and maximum antifibrotic effect were observed in young mice, while adult mice exhibited pronounced immunotoxicity and weak response to interferon therapy.
Filimonov
P N
PN
Novosibirsk State Medical Academy, and Institute of Clinical Immunology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk.
Sukhenko
T G
TG
Gavrilova
N I
NI
Shkurupii
V A
VA
D000375:Aging / Q000187:drug effects* / Q000276:immunology*; D000818:Animals; D002251:Carbon Tetrachloride; D002478:Cells, Cultured; D016898:Interferon-alpha / Q000494:pharmacology / Q000627:therapeutic use*; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
D016898:Interferon-alpha; D002251:Carbon Tetrachloride