Contraction-induced myokine production and release: is skeletal muscle an endocrine organ?
The concentration of plasma interleukin-6 (IL-6) increases during physical exercise, but until recently the cellular origin of this increase has been unknown. Recent work has identified that skeletal muscle is a major source of this increase and the release of IL-6 from muscle can mediate metabolic processes. IL-6 is, therefore, the first identified "myokine" released from muscle that can now be termed an endocrine organ.
Febbraio
Mark A
MA
Cellular and Molecular Metabolism Laboratory, RMIT University, Bundoora, Australia.
Pedersen
Bente K
BK
D016207:Cytokines / Q000096:biosynthesis*; D004703:Endocrine System / Q000502:physiology; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D032342:Muscle Cells / Q000378:metabolism*; D009119:Muscle Contraction / Q000502:physiology*; D018482:Muscle, Skeletal / Q000378:metabolism*
D016207:Cytokines; D015850:Interleukin-6