Autoimmune nature of influenza atherogenicity.
It has been observed during influenza epidemics and in a number of population and clinical trials that this prevalent viral infection was associated with increased death rates from cardiovascular diseases. The clinical and experimental data that may explain accelerated coronary atherosclerosis in influenza infection with implications involving autoimmune mechanisms are analyzed in this article. Both cellular and humoral autoimmune modes could be proposed to participate in the onset or progression of atheromatous lesions due to influenza infection.
Gurevich
Victor S
VS
Center of Atherosclerosis and Lipid Disorders, Chair of Cardiology, Mechnicov's State Medical Academy, Saint Petersburg, Russia. gur@cards.lanck.net
Pleskov
Vladimir M
VM
Levaya
Margarita V
MV
D000818:Animals; D000917:Antibody Formation; D001323:Autoantibodies / Q000276:immunology; D015551:Autoimmunity; D003324:Coronary Artery Disease / Q000209:etiology* / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007252:Influenza Vaccines / Q000008:administration & dosage; D007251:Influenza, Human / Q000150:complications* / Q000517:prevention & control; D008077:Lipoproteins, LDL / Q000276:immunology; D018716:Molecular Mimicry
D001323:Autoantibodies; D007252:Influenza Vaccines; D008077:Lipoproteins, LDL