[Association between A49T polymorphism of SRD5A2 gene and risk of prostate cancer].
OBJECTIVE
To investigate the association between A49T polymorphism of SRD5A2 gene and risk of prostate cancer.


METHODS
PCR was used to examine the A49T polymorphisms of SRD5A2 gene in the tissues of prostate cancer resected from 112 patients (CaP group) and the specimens of benign prostate hyperplasia (BPH group) resected from 89 patients. The association of A49T polymorphism with age of onset, FPSA, TPSA, F/T, T stage, and Gleason score were analyzed.


RESULTS
There was no significant difference in A49T polymorphism between the CaP and BPH groups (P > 0.05). The average age of CaP patients was significantly higher than that of the BPH patients (P < 0.05). In the CaP patients, the Gleason score was significantly higher, and the age of onset was significantly lower in the AT + TT genotype than in the AA genotype (both P < 0.05) 2. The age of onset of the AA + AT group was significantly lower than that of the AA group (P < 0.05).


CONCLUSIONS
AA + AT genotype may be of worse prognosis, however, without significant difference. Rank scoring may reflect the relation between Gleason score and A49T genotype and estimate the prognosis better than two-level discrete evaluation.
Tong
Ming
M
Department of Urinary Surgery, Peking University First Hospital, Beijing 100034, China.
Ai
Jun-kui
JK
Yuan
Yi-ming
YM
Yin
Yi
Y
Zhou
Li-qun
LQ
Xin
Dian-qi
DQ
Li
Ming
M
Na
Yan-qun
YQ
D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000235:genetics*; D000368:Aged; D000369:Aged, 80 and over; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors
D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase