title: Solitary Langerhans cell histiocytosis of the sternum in a 6-year-old girl: how should it be treated?
abstract: We report a 6-year-old girl with Langerhans cell histiocytosis (LCH) of the sternum successfully managed with intralesional methylprednisolone. Sternal LCH is a rare condition with only 8 cases published to date. Management has included partial sternectomy, radiotherapy, and chemotherapy. Recent literature regarding the solitary osseous focus of LCH supports conservative management with excellent outcome after intralesional steroid administration and reports of spontaneous resolution of disease. We advocate that conservative management should also be applied to LCH of the sternum.
authors: Department of Pediatric Surgery, Wilhelmina Children's Hospital, University Medical Centre, 3508 AB Utrecht, The Netherlands.
authors: Guin J P
authors: GJ
authors: Wilson
authors: A Birgitta
authors: AB
authors: Versluys
authors: Klaas N M A
authors: KN
authors: Bax
mesh_terms: D002648:Child; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006646:Histiocytosis, Langerhans-Cell / Q000188:drug therapy*; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use*; D013249:Sternum / Q000473:pathology*
chemical_list: D005938:Glucocorticoids; D008775:Methylprednisolone