title: [Preliminary study on genotype of hepatitis B virus detected from Tibetans in China].
abstract: OBJECTIVE
  To determine the main genotype of hepatitis B virus (HBV) detected from Tibetans in China and provide basic data for hepatitis control and prevention.
  
  
  METHODS
  The S gene and C gene were amplified by PCR from the sera of HBsAg positive Tibetans. After sequencing, the gene sequences were analyzed and the phylogenetic trees were drawn by the software MEGA3.
  
  
  RESULTS
  In trees based on S gene, the sequences of most samples clustered at genotype D, while in trees based on C gene, the sequences of all samples clustered at genotype C.
  
  
  CONCLUSIONS
  The dominant genotype of HBV detected from Tibetans in China is a C/D hybrid.
authors: Department of Hepatitis Virus, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China.
authors: Yan-qing
authors: YQ
authors: Xu
authors: Yong-dong
authors: YD
authors: Zhou
authors: Sheng-li
authors: SL
authors: Bi
mesh_terms: D005838:Genotype; D006509:Hepatitis B / Q000097:blood / Q000453:epidemiology / Q000821:virology*; D006512:Hepatitis B Core Antigens / Q000235:genetics; D006514:Hepatitis B Surface Antigens / Q000097:blood / Q000235:genetics; D006515:Hepatitis B virus / Q000145:classification / Q000235:genetics* / Q000276:immunology; D006801:Humans; D010802:Phylogeny; D018609:Tibet / Q000453:epidemiology
chemical_list: D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens