title: Pathogenicity of Helicobacter pylori infection.
abstract: Numerous Helicobacter pylori virulence factors, including various enzymes (urease, catalase, lipase, phospholipase and proteases), vacuolating cytotoxin (a product of expression of the vacA gene), and the immunogenic protein CagA, encoded by the cagA gene localised in the H. pylori pathogenicity island, are involved in the pathomechanism of infection caused by these organisms. This review presents the current state of knowledge concerning the molecular mechanisms and epidemiology of H. pylori infection, based on the published literature and recent unpublished observations.
authors: Department of Medical Microbiology, Medical University of Silesia, Katowice, Poland.
authors: H
authors: H
authors: Radosz-Komoniewska
authors: T
authors: T
authors: Bek
authors: J
authors: J
authors: Jóźwiak
authors: G
authors: G
authors: Martirosian
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics; D016481:Helicobacter Infections / Q000453:epidemiology / Q000382:microbiology / Q000503:physiopathology*; D016480:Helicobacter pylori / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D006801:Humans; D051379:Mice; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D037521:Virulence Factors