[Pregnancy after ABO and Rh mismatched allotransplantation of peripheral blood progenitor cells, complicated by Rh disease].
We describe the case of a woman, who changed her blood group phenotype from Rh plus to Rh minus, as an effect of peripheral blood progenitor cells allotransplantation, and produced anti-Rh-D antibodies at an early stage of her first pregnancy. These antibodies were directed against blood red cells of the fetus, who inherited Rh-D antigen after his mother. During the pregnancy came to a light figure of a Rh disease. Because of the clinical appearance of this disease we assume, that the primary immunization had place before the pregnancy and was complication of the RhD mismatched transplantation. We think, that allotransplantation of hemopoietic cells provides a new, but essential source of immunization of women, who become pregnant after completion of the treatment. It may concern to Rh antigens, but probably also other, less known antigens.
Samsel
Marzena
M
Klinika Ginekologii i Połoinictwa CMKP, SPSK im. prof. W. Orlowskiego, Warszawa.
Debski
Romuald
R
Sedzimirska
Mariola
M
D000017:ABO Blood-Group System / Q000276:immunology*; D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy; D001787:Blood Group Incompatibility; D001805:Blood Transfusion, Intrauterine; D004899:Erythroblastosis, Fetal; D005260:Female; D006801:Humans; D036102:Peripheral Blood Stem Cell Transplantation; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood*; D011256:Pregnancy Outcome; D012204:Rh-Hr Blood-Group System / Q000097:blood / Q000276:immunology*; D013997:Time Factors; D014184:Transplantation, Homologous
D000017:ABO Blood-Group System; D012204:Rh-Hr Blood-Group System; C026410:Rho(D) antigen