title: Cortical calcium waves in resting newborn mice.
abstract: Using a new optical fiber-based approach, we demonstrate the presence of recurrent Ca(2+) transients in cortical neurons of non-anesthetized newborn mice in vivo. These Ca(2+) waves reflect the correlated activity of thousands of cells and were detected only in resting, but not in moving pups. Our results suggest that Ca(2+)-dependent cortical maturation occurs predominantly during the intermittent sleep-like resting periods that are characteristic for the first days of postnatal life.
authors: Physiologisches Institut, Ludwig-Maximilians Universität München, Pettenkoferstr. 12, 80336 München, Germany.
authors: Helmuth
authors: H
authors: Adelsberger
authors: Olga
authors: O
authors: Garaschuk
authors: Arthur
authors: A
authors: Konnerth
mesh_terms: D000814:Aniline Compounds; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002540:Cerebral Cortex / Q000166:cytology / Q000378:metabolism*; D005336:Fiber Optic Technology; D005452:Fluoresceins; D005456:Fluorescent Dyes; D051379:Mice; D009474:Neurons / Q000378:metabolism; D055100:Optical Fibers; D009991:Oscillometry; D017785:Photons; D012146:Rest / Q000502:physiology*
chemical_list: D000814:Aniline Compounds; D005452:Fluoresceins; D005456:Fluorescent Dyes; C503942:Oregon green 488 BAPTA-1; D002118:Calcium