title: Spectral polarization imaging of human prostate cancer tissue using a near-infrared receptor-targeted contrast agent.
abstract: The Cypate-Bombesin Peptide Analogue Conjugate (Cybesin) was used as a prostate tumor receptor-targeted contrast agent. The absorption and fluorescence spectra of Cybesin were measured and shown to exist in the NIR tissue "optical window". The spectral polarization imaging of Cybesin-stained prostate cancerous and normal tissues shows that prostate cancerous tissue takes-up more Cybesin than that of prostate normal tissue, making Cybesin a potential marker of prostate cancer.
authors: Department of Electrical Engineering, The City College of the City Univ. of NY, Convent Avenue at 138th Street, New York, NY 10031, USA.
authors: Y
authors: Y
authors: Pu
authors: W B
authors: WB
authors: Wang
authors: G C
authors: GC
authors: Tang
authors: F
authors: F
authors: Zeng
authors: S
authors: S
authors: Achilefu
authors: J H
authors: JH
authors: Vitenson
authors: I
authors: I
authors: Sawczuk
authors: S
authors: S
authors: Peters
authors: J M
authors: JM
authors: Lombardo
authors: R R
authors: RR
authors: Alfano
mesh_terms: D001839:Bombesin / Q000737:chemistry; D003287:Contrast Media / Q000494:pharmacology; D006801:Humans; D008297:Male; D008956:Models, Chemical; D010455:Peptides / Q000737:chemistry; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D013050:Spectrometry, Fluorescence; D013053:Spectrophotometry; D019265:Spectroscopy, Near-Infrared / Q000295:instrumentation* / Q000379:methods*
chemical_list: D003287:Contrast Media; D010455:Peptides; D001839:Bombesin