[Effect of puerarin on the expression of Hsp70 in the rats with cerebral injury induced by acute local ischemia].
OBJECTIVE
To study the effect of puerarin on the expression of Hsp (heat shock protein) 70 in the rats with cerebral injury induced by acute local ischemia.


METHODS
Rat model of acute local cerebral ischemia was made by ligating middle cerebral artery. The Hsp70 expression in brain tissue was detected by SP method of immunohistochemistry.


RESULTS
The expression of Hsp70 was significantly higher in puerarintreated rats than those in the rats with cerebral ischemia.


CONCLUSIONS
Puerarin can enhance the level of Hsp70 expression in the rats with cerebral injury induced by acute local ischemia.
Pan
Hong-ping
HP
People's Hospital of Guangxi Autonomous Region, Nanning 530021, China. php1968@126.com
Mo
Xiang-lan
XL
Yang
Jia-zhen
JZ
Li
Lu-li
LL
Huang
Zhen-lu
ZL
Ye
Jin
J
Huang
Jin
J
D000818:Animals; D002545:Brain Ischemia / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D020244:Infarction, Middle Cerebral Artery / Q000150:complications; D007529:Isoflavones / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000378:metabolism; D018696:Neuroprotective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D029908:Pueraria / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
D018840:HSP70 Heat-Shock Proteins; D007529:Isoflavones; D018696:Neuroprotective Agents; C033607:puerarin