Moyamoya syndrome with intraventricular hemorrhage in an adult with factor V Leiden mutation.
OBJECTIVE
To report a case of proximal occlusion of 2 major cerebral vessels associated with moyamoya network circulation that manifested by spontaneous intraventricular hemorrhage.


METHODS
Case report.


RESULTS
A 36-year-old Syrian man presented with symptoms of sudden-onset headache, neck stiffness, and confusion. The computed tomography scan of his brain showed intraventricular bleeding, and the subsequent 4 vessel angiographies revealed occlusion of the left middle and anterior cerebral arteries with moyamoya appearance in the terminal branches. The coagulation profile showed the presence of heterozygous factor V Leiden mutation. The patient was treated conservatively until resolution of his blood clot, and later he was started on oral anticoagulation.


CONCLUSIONS
Factor V Leiden mutation may cause large cerebral vessel occlusion with moyamoya syndrome in adults.
Jabbour
Rosette
R
Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon. rj04@aub.edu.lb
Taher
Ali
A
Shamseddine
Ali
A
Atweh
Samir F
SF
D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D002533:Cerebral Angiography; D005165:Factor V / Q000235:genetics*; D006801:Humans; D020300:Intracranial Hemorrhages / Q000209:etiology*; D008297:Male; D009072:Moyamoya Disease / Q000150:complications* / Q000473:pathology*; D014057:Tomography, X-Ray Computed
D000925:Anticoagulants; C095381:factor V Leiden; D005165:Factor V