title: Antileishmanial agents part-IV: synthesis and antileishmanial activity of novel terpenyl pyrimidines.
abstract: Some novel N- and O-substituted terpenyl pyrimidines 4 (a-j) have been synthesized and screened for in vitro antileishmanial activity profile in promastigote model. Some of the compounds exhibited 100% inhibition at 10 microg ml(-1) concentration.
authors: Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India.
authors: Naveen
authors: N
authors: Chandra
authors: Ramesh
authors: Ashutosh
authors: Neena
authors: N
authors: Goyal
authors: S N
authors: SN
authors: Suryawanshi
authors: Suman
authors: S
authors: Gupta
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007891:Leishmania / Q000187:drug effects* / Q000254:growth & development; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000981:Antiprotozoal Agents; D011743:Pyrimidines; D013729:Terpenes