Association between C-reactive protein and insulin resistance in a Japanese population: the Minoh Study.
OBJECTIVE
To investigate the association between C-reactive protein (CRP) and insulin resistance.


METHODS
This study included 1,624 Japanese participants (652 men and 972 women) aged 40 to 69 years who were non-diabetics or did not have medication for hypertension or dyslipidemia, a history of cardiovascular disease or CRP levels >10 mg/l. Serum CRP level, fasting glucose level, and fasting insulin level were measured, and the degree of insulin resistance was assessed using the homeostasis model assessment of insulin resistance (HOMA-IR). Categories of CRP were defined by the following tertiles: <0.25 mg/l, 0.25-0.59 mg/l, and > or = 0.60 mg/l.


RESULTS
Elevated CRP levels were associated with increased fasting insulin levels, fasting glucose levels, and HOMA-IR in both men and women. Although the adjustment for body mass index in addition to age, cigarette smoking, and alcohol consumption attenuated the associations between CRP and fasting insulin, fasting glucose, and HOMA-IR, elevated CRP levels were associated with increased insulin levels and HOMA-IR in both sexes. Stratified analyses by CRP level and obesity showed that obesity status was associated with increased fasting insulin levels, fasting glucose levels, and HOMA-IR in both sexes and that fasting insulin levels, fasting glucose levels, and HOMA-IR were higher among obese individuals than among non-obese individuals at the same level of CRP.


CONCLUSIONS
These results suggest a possible role of subclinical inflammation in insulin resistance and glucose intolerance in Japanese, but it only partly explains the link between obesity and impaired glucose homeostasis.
Nakanishi
Noriyuki
N
Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine, Yamada-oka, Suita.
Shiraishi
Tsunehito
T
Wada
Mariko
M
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000209:etiology; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology; D007564:Japan; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009391:Nephelometry and Turbidimetry; D011159:Population Surveillance; D012016:Reference Values; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D011795:Surveys and Questionnaires
D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin; D002097:C-Reactive Protein