title: Positive association of the human GABA-A-receptor beta 2 subunit gene haplotype with schizophrenia in the Chinese Han population.
abstract: A converging body of evidence implicates the gamma-amino butyric acid neurotransmitter system in the pathogenesis of schizophrenia. Recently, Lo et al. reported strong positive association between schizophrenia and GABRB2, demonstrated by single markers and haplotypes of five markers in introns of GABRB2, rs6556547, rs1816071, rs194072, rs252944, and rs187269. To validate this linkage disequilibrium report, we genotyped these five SNPs and additional rs1816072 in 352 Chinese Han family trios. Though we failed to detect any positive results in single markers, we did find a significant haplotypic association (global p = 0.00157-0.00588) which had not been identified in Lo's study. Our data indicated that the haplotype 'GACTCT' (p = 0.00215, frequency = 53.6%) was overtransmitted which suggests that GABRB2 is in linkage disequilibrium with schizophrenia in the Chinese Han population. The difference between the two studies may be due to the respective analytic power of the two designs. These two independent studies highlighting linkage disequilibrium support the potential involvement of GABRB2 or a nearby gene in the genetic etiology of schizophrenia.
authors: Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, PR China.
authors: Jixia
authors: J
authors: Liu
authors: Yongyong
authors: Y
authors: Shi
authors: Wei
authors: W
authors: Tang
authors: Tingwei
authors: T
authors: Guo
authors: Dawei
authors: D
authors: Li
authors: Yifeng
authors: Y
authors: Yang
authors: Xinzhi
authors: X
authors: Zhao
authors: Hongsheng
authors: H
authors: Wang
authors: Xingwang
authors: X
authors: Li
authors: Guoyin
authors: G
authors: Feng
authors: Niufan
authors: N
authors: Gu
authors: Shaomin
authors: S
authors: Zhu
authors: Huijun
authors: H
authors: Liu
authors: Yangling
authors: Y
authors: Guo
authors: Jianguo
authors: J
authors: Shi
authors: Hong
authors: H
authors: Sang
authors: Lijuan
authors: L
authors: Yan
authors: Lin
authors: L
authors: He
mesh_terms: D044466:Asian People / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D005260:Female; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011963:Receptors, GABA-A / Q000235:genetics*; D012559:Schizophrenia / Q000208:ethnology* / Q000235:genetics*
chemical_list: C495710:GABRB2 protein, human; D011963:Receptors, GABA-A