title: A deiminated viral peptide to detect antibodies in rheumatoid arthritis.
abstract: The data presented suggest that a deiminated viral peptide is specifically recognized by antibodies contained in rheumatoid arthritis (RA) sera. Antipeptide antibodies are not associated with the presence or severity of specific manifestations of RA, but are more frequent in subjects with erosive arthritis. Taking into account the association with rheumatoid factor and with erosive arthritis, we can conclude that antipeptide antibodies are markers of severe forms of RA. Our data also show familial aggregation of anticitrullinated peptide antibodies.
authors: Clinical Immunology Unit, Department of Internal Medicine, Via Roma 67, 56126 Pisa, Italy. p.migliorini@med.unipi.it
authors: Giuseppina
authors: G
authors: Merlini
authors: Consuelo
authors: C
authors: Anzilotti
authors: Daniele
authors: D
authors: Chimenti
authors: Cristina
authors: C
authors: Tommasi
authors: Stefano
authors: S
authors: Bombardieri
authors: Paola
authors: P
authors: Migliorini
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies / Q000097:blood*; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002956:Citrulline / Q000276:immunology; D003449:Cryoglobulinemia / Q000097:blood / Q000175:diagnosis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007097:Imines / Q000737:chemistry*; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000737:chemistry / Q000276:immunology; D012595:Scleroderma, Systemic / Q000097:blood / Q000175:diagnosis; D014764:Viral Proteins / Q000737:chemistry* / Q000276:immunology*
chemical_list: D000906:Antibodies; D015415:Biomarkers; D007097:Imines; D010446:Peptide Fragments; D014764:Viral Proteins; D002956:Citrulline