The first total synthesis of alpha-D-glucopyranosyl-(1-->2)-beta-D-galactopyranosyl-O-pyridinoline, an important hallmark of human joint diseases.
The first total synthesis of alpha-D-glucopyranosyl-(1-->2)-beta-D-galactopyranosyl-O-pyridinoline using a short "one-pot" assembly of its 1,4,5-trisubstituted 3-hydroxypyridinium ring is reported.
Allevi
Pietro
P
Dipartimento di Chimica, Biochimica e Biotecnologie per la Medicina, Università di Milano, via Saldini 50, I-20133 Milano, Italy. pietro.allevi@unimi.it
Cribiù
Riccardo
R
Giannini
Elios
E
Anastasia
Mario
M
D004187:Disaccharides / Q000138:chemical synthesis* / Q000378:metabolism; D006801:Humans; D007592:Joint Diseases / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D011725:Pyridines / Q000138:chemical synthesis* / Q000378:metabolism; D021241:Spectrometry, Mass, Electrospray Ionization
D004187:Disaccharides; D011725:Pyridines; C505635:alpha-D-glucopyranosyl-(1-2)-beta-D-galactopyranosyl-O-pyridinoline