Dendrimer-like PEO glycopolymers exhibit anti-inflammatory properties.
A new class of high molecular weight polysulfated PEO dendrimer-like glycopolymer has been synthesized by a combination of arm-first and core-first methodologies followed by trichloroacetimidate glycosidation as a facile bioconjugation strategy. An L-selectin antagonist was identified that exhibits 103-fold greater activity than other multivalent sLex glycopolymers and 20-50 times greater potency than other linear heparinoids. A significant reduction in inflammatory cell recruitment was observed in vivo.
Rele
Shyam M
SM
Department of Surgery, Emory University, and School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30322, USA.
Cui
Wanxing
W
Wang
Lianchun
L
Hou
Sijian
S
Barr-Zarse
Ginger
G
Tatton
Daniel
D
Gnanou
Yves
Y
Esko
Jeffrey D
JD
Chaikof
Elliot L
EL
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000494:pharmacology; D006031:Glycosylation; D006801:Humans; D019041:L-Selectin / Q000737:chemistry / Q000378:metabolism; D007785:Lactose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D009844:Oligosaccharides / Q000737:chemistry / Q000378:metabolism; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000494:pharmacology*; D000080506:Sialyl Lewis X Antigen; D020298:U937 Cells
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009844:Oligosaccharides; D000080506:Sialyl Lewis X Antigen; D019041:L-Selectin; D011092:Polyethylene Glycols; D007785:Lactose