title: Calprotectin, a marker of inflammation, is elevated in the maternal but not in the fetal circulation in preeclampsia.
abstract: OBJECTIVE
  Preeclampsia is associated with excessive inflammatory response compared with normal pregnancy. Calprotectin is an inflammation marker not previously explored in preeclampsia.
  
  
  METHODS
  Calprotectin in maternal and fetal plasma and amniotic fluid was investigated at cesarean delivery in normal pregnancies and preeclampsia. C-reactive protein (CRP) and plasminogen activator inhibitor type1 (PAI-1) were also analyzed.
  
  
  RESULTS
  Maternal median calprotectin, CRP, and PAI-1 concentrations were elevated in preeclampsia (1081 microg/L, 4.8 mg/L, and 51.0 U/mL) compared with control levels (552 microg/L, 3.8 mg/L, and 36.5 U/mL). In the umbilical vein, there were no differences between preeclampsia and controls regarding calprotectin and CRP levels. Maternal calprotectin concentrations correlate with CRP and PAI-1 values for the total study group, but a statistical significant correlation was not found in the preeclamptic group.
  
  
  CONCLUSIONS
  Calprotectin is elevated in the maternal circulation in preeclamptic pregnancies. We found no evidence of inflammatory response in the fetal circulation in preeclampsia.
authors: Department of Pediatrics, Ulleval University Hospital, Oslo, Norway. krb@broadpark.no
authors: Kristin
authors: K
authors: Braekke
authors: Mette R
authors: MR
authors: Holthe
authors: Nina Kittelsen
authors: NK
authors: Harsem
authors: Magne K
authors: MK
authors: Fagerhol
authors: Anne Cathrine
authors: AC
authors: Staff
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D002585:Cesarean Section; D005260:Female; D005312:Fetal Blood; D006801:Humans; D007249:Inflammation / Q000097:blood*; D039841:Leukocyte L1 Antigen Complex / Q000097:blood* / Q000378:metabolism; D009994:Osmolar Concentration; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood* / Q000378:metabolism; D011247:Pregnancy / Q000097:blood*
chemical_list: D015415:Biomarkers; D039841:Leukocyte L1 Antigen Complex; D017395:Plasminogen Activator Inhibitor 1; D002097:C-Reactive Protein