Effects of short-term treatment with systemic prednisone on bone healing: an experimental study in rats.
Long-term systemic use of corticosteroids causes osteoporosis and increased risk of fracture. However, the effect of short-term use of corticosteroids on bone healing is not well defined. The aim of the present study was to test the influence of short-term systemic corticosteroid therapy on bone healing. Standardized bone defects (2 mm diameter) were formed in the middle of the femur in 40 male rats. Rats were divided into two groups; control group (n = 20) and prednisone-treated group (n = 20). Subcutaneous injection of either sterile normal saline (control) or 0.020 mg kg(-1) dose of prednisone was administered just before surgery and thereafter daily for 3 days. Histopathological cross sections were taken 1, 2, 3 and 4 weeks after surgery. There was no statistically significant difference between the prednisone group and the control group. No inhibitory effects were seen following short-term corticosteroid treatment.
Aslan
Muzaffer
M
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ataturk University, Erzurum, Turkey. drmaslan@yahoo.com
Simşek
Göksel
G
Yildirim
Umran
U
D000818:Animals; D001847:Bone Diseases / Q000188:drug therapy* / Q000473:pathology; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology; D003238:Connective Tissue / Q000187:drug effects / Q000473:pathology; D005269:Femur / Q000187:drug effects* / Q000473:pathology; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D007279:Injections, Subcutaneous; D008297:Male; D010012:Osteogenesis / Q000187:drug effects; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects
D005938:Glucocorticoids; D012965:Sodium Chloride; D011241:Prednisone