Bovine spongiform encephalopathy, multiple sclerosis, and creutzfeldt-jakob disease are probably autoimmune diseases evoked by Acinetobacter bacteria.
Bovine spongiform encephalopathy (BSE) belongs to a group of conditions named together as transmissible spongiform encephalopathies (TSE). They are fatal neurodegenerative diseases that include "scrapie" in sheep, Creutzfeldt-Jakob disease (CJD) and kuru in humans, and chronic wasting disease in deers. BSE-affected animals suffer from "hindquarters" paralysis, which is also one of the main features of "experimental allergic encephalomyelitis" (EAE). EAE is considered an animal model of multiple sclerosis (MS) and lower limb ataxia is often observed in MS patients. The presence of clinical and histopathological similarities in these diseases suggests a common pathology. Specific brain peptides, which produce EAE, were shown to have "molecular mimicry" with the soil and skin saprophytic microbe, Acinetobacter. BSE-affected animals and patients suffering from MS have been found to have elevated levels of antibodies to both Acinetobacter and Pseudomonas bacteria, as well as autoantibodies to both white and gray matter brain components. The hypothesis is proposed that Acinetobacter/Pseudomonas bacteria may have evoked both BSE and MS through the mechanism of "molecular mimicry" and autoimmunity in a similar way to Streptococcus microbes producing rheumatic fever and Sydenham's chorea. The possibility that CJD patients may show similar features remains to be determined.
Ebringer
Alan
A
Infection and Immunity Group, Division of Health and Life Sciences, King's College London, 150 Stamford Street, London SE1 9NN, United Kingdom. alan.ebringer@kcl.ac.uk
Rashid
Taha
T
Wilson
Clyde
C
D000150:Acinetobacter / Q000276:immunology*; D000818:Animals; D015551:Autoimmunity; D002417:Cattle; D007562:Creutzfeldt-Jakob Syndrome / Q000276:immunology* / Q000473:pathology; D003670:Deer; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000473:pathology; D016643:Encephalopathy, Bovine Spongiform / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007729:Kuru / Q000276:immunology / Q000473:pathology; D018716:Molecular Mimicry; D009103:Multiple Sclerosis / Q000276:immunology* / Q000473:pathology; D012608:Scrapie / Q000276:immunology / Q000473:pathology; D012756:Sheep; D034081:Wasting Disease, Chronic / Q000276:immunology / Q000473:pathology