title: [Effects of HCMV on phenotypes of parotid duct epithelial cells and its mechanisms].
abstract: OBJECTIVE
  To investigate the effects of HCMV infection on phenotypes of parotid duct epithelial cells and relative mechanisms.
  
  
  METHODS
  The expressions of immediate early antigen of HCMV, pan cytokeratin and cathepsin D etc. were detected by immunohistochemical staining in tissues of parotid cytomegalic inclusion disease.
  
  
  RESULTS
  Cytokeratin which acts as an epithelial marker became negative while staining of Cathepsin D was intensified in parotid duct epithelial cells after infected by HCMV.
  
  
  CONCLUSIONS
  It demonstrated that cytokeratin was lost through over-expression of Cathepsin D in parotid duct epithelial cells infected by HCMV.
authors: Hematology Department, Lanzhou General Hospital, Lanzhou 730050, China.
authors: Guo-rong
authors: GR
authors: Yang
authors: Gao-sheng
authors: GS
authors: Huang
authors: Hai
authors: H
authors: Bai
authors: En-hua
authors: EH
authors: Wang
authors: Ji-ye
authors: JY
authors: Song
authors: Ying
authors: Y
authors: Guo
authors: Juan-hong
authors: JH
authors: Wang
authors: Rong
authors: R
authors: Liang
authors: Zhe
authors: Z
authors: Wang
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D002402:Cathepsin D / Q000032:analysis; D003587:Cytomegalovirus / Q000276:immunology / Q000502:physiology*; D003586:Cytomegalovirus Infections / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D003893:Desmin / Q000032:analysis; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D054884:Host-Pathogen Interactions; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007633:Keratins / Q000032:analysis; D008297:Male; D051379:Mice; D018987:Salivary Ducts / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D014746:Vimentin / Q000032:analysis; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D000956:Antigens, Viral; D002402:Cathepsin D; D003893:Desmin; D005904:Glial Fibrillary Acidic Protein; D007633:Keratins; D014746:Vimentin; C067980:CD68 antigen, human; D000097382:CD68 Molecule