Getting a molecular grasp on Hox contextual activity.
Hox genes encode evolutionarily conserved transcription factors with key functions in development and evolution. Although the multitude of processes individually controlled by Hox proteins highlights the importance of contextual information in setting their diverse activities, the underlying molecular mechanisms still remain elusive. A recent study identified novel Hox molecular partners, whose properties set a conceptual framework to understand how Hox proteins use and integrate contextual information.
Merabet
Samir
S
Laboratoire de Génétique et Physiologie du Développement, IBDM, CNRS, Université de la Méditerranée, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 09, France.
Pradel
Jacques
J
Graba
Yacine
Y
D000818:Animals; D019521:Body Patterning / Q000502:physiology; D004330:Drosophila / Q000196:embryology / Q000502:physiology; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D005801:Genes, Homeobox; D018398:Homeodomain Proteins / Q000235:genetics / Q000502:physiology*; D011485:Protein Binding; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology
D029721:Drosophila Proteins; C063459:En protein, Drosophila; D018398:Homeodomain Proteins; D014157:Transcription Factors; C117261:distal-less protein, insect; C074838:slp1 protein, Drosophila