[Role of arrestins in intracellular signaling].
Arrestins are cytosolic proteins involved in the termination of signaling by activated G protein-coupled receptors (GPCR). Four different arrestins are identified in mammals to date. Two of these are specific to retinal photoreceptor cells, while the other two (beta-arrestin 1 and 2) are ubiquitously expressed. Recently, several new regulatory functions of arrestins in such processes as receptor ubiquitination, signaling through kinases, and others have been discovered.
Szymiczek
Magdalena
M
Laboratorium Białek Sygnałowych, Instytut Immunologii i Terapii Doświadczalnej PAN im. L. Hirszfelda we Wrocławiu.
Kurowska
Ewa
E
Gorczyca
Wojciech A
WA
D000818:Animals; D019390:Arrestins / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D010786:Photoreceptor Cells / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D000071559:beta-Arrestin 1; D000071557:beta-Arrestins
C000605253:ARRB1 protein, human; D019390:Arrestins; D043562:Receptors, G-Protein-Coupled; D000071559:beta-Arrestin 1; D000071557:beta-Arrestins