Novel HLA-A*11 allele, A*1120, identified by sequence-based typing.
In this report, we describe the identification of a human leucocyte antigen-A*11 (HLA-A*11) nucleotide sequence variant, a new HLA-A*1120 by using sequence-based typing (SBT). The new allele was detected during routine HLA typing by high-resolution SBT. Allele A*1120 showed one nucleotide difference with A*110101 at codon 152 (GCG-->GAG) resulting in an amino acid change from alanine to glutamate. Residue 152 is located on alpha(2)-helix of HLA class I molecule and involved in peptide binding by constructing E pocket of peptide-binding groove, implying that the change of the residue 152 would affect the binding affinity of peptides to A*1120 allele.
Kwon
O-J
OJ
BioSewoom Institute of Bioscience and Biotechnology, University of Ulsan College of Medicine, Seoul, Korea.
Hwang
S-H
SH
Heo
Y-S
YS
Hur
S-S
SS
Lee
M-N
MN
Oh
H-B
HB
D000483:Alleles; D044466:Asian People / Q000235:genetics; D001483:Base Sequence; D005091:Exons; D015234:HLA-A Antigens / Q000235:genetics* / Q000276:immunology*; D006650:Histocompatibility Testing / Q000379:methods; D006801:Humans; D007723:Korea / Q000208:ethnology; D008954:Models, Biological; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D011485:Protein Binding; D016415:Sequence Alignment
D015234:HLA-A Antigens