Clinical system for interstitial photodynamic therapy with combined on-line dosimetry measurements.
A system for interstitial photodynamic therapy with delta-aminolaevulinic acid and multiple optical fibers has been developed. The system enables photodynamic treatment of large embedded tumor volumes and utilizes real-time measurements to allow on-line dosimetry. Important parameters such as light fluence rate, sensitizer fluorescence intensity, and changes in local blood oxygen saturation are measured with the same fibers that deliver the therapeutic light. Data from the first clinical treatments on nodular basal cell carcinomas indicate a major treatment-induced light absorption increase, rapid sensitizer photobleaching, and a relatively constant global tissue oxygen saturation level during the treatment.
Thompson
Marcelo Soto
MS
Department of Physics, Lund Institute of Technology, PO Box 118, SE-221 00 Lund, Sweden. marcelo@fysik.lth.se
Johansson
Ann
A
Johansson
Thomas
T
Andersson-Engels
Stefan
S
Svanberg
Sune
S
Bendsoe
Niels
N
Svanberg
Katarina
K
D000622:Aminolevulinic Acid / Q000008:administration & dosage*; D002280:Basal Cell Carcinoma / Q000188:drug therapy*; D003199:Computer Systems; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005336:Fiber Optic Technology / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D008027:Light; D009862:Online Systems; D055100:Optical Fibers; D010778:Photochemotherapy / Q000295:instrumentation* / Q000379:methods; D017319:Photosensitizing Agents / Q000008:administration & dosage; D011829:Radiation Dosage; D012878:Skin Neoplasms / Q000188:drug therapy*; D013050:Spectrometry, Fluorescence / Q000295:instrumentation* / Q000379:methods; D018511:Systems Integration; D013813:Therapy, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D016896:Treatment Outcome; D014584:User-Computer Interface
D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid