Effect of imidazobenzoimidazole derivatives RU-353, RU-563, and lidocaine on cerebral circulation in rats.
We demonstrated a dose-dependent inhibitory effect of novel imidazobenzoimidazole derivatives RU-353 and RU-563 on cerebral blood flow and systemic blood pressure in narcotized rats. The effects of RU-353 increased, while the effect of RU-563 decreased with increasing the dose.
Galenko-Yaroshevskii
A P
AP
Kuban State Medical Academy, Krasnodar; Krasnodar Regional Research Medical Center, Russia.
Turovaya
A Yu
AY
Uvarov
A V
AV
Prikhod'ko
A K
AK
Ivashev
M N
MN
Arl't
A V
AV
Anisimova
V A
VA
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D001562:Benzimidazoles; C507880:RU 353; C507881:RU 563; D008012:Lidocaine