Aspects of the humoral and cellular immune response in hepatitis associated with cholelithiasis.
OBJECTIVE
To investigate the immunological reactions of the liver in various gall bladder disease.


METHODS
IgG, IgA and IgM were measured in the blood and bile of patients with cholecystectomy. Immunofluorescence and electron microscopy techniques were used.


RESULTS
The tests showed high blood values of immunoglobulins and their presence in the bile. The immunofluorescence was positive for IgG in the hepatic sinusoids. The electron microscopy showed aspects of "cellular cooperation".


CONCLUSIONS
On the basis of our results we can affirm that in cholelithiasis there exists an immune response to the persistent antigens, with the release of circulating immune complexes.
Bădescu
Maria Elisabeta
ME
Gr.T. Popa University of Medicine and Pharmacy, Iaşi School of Medicine, Department of Pathology.
Stancu
Manuela
M
Pandele
G I
GI
Cotuţiu
C
C
Amălinei
Cornelia
C
Balan
Raluca
R
D001646:Bile / Q000276:immunology; D002769:Cholelithiasis / Q000150:complications* / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006505:Hepatitis / Q000150:complications* / Q000276:immunology*; D022781:Hepatocytes / Q000648:ultrastructure; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008854:Microscopy, Electron
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M