[The multiple character of mutation of resistance to mitomycin C in Erwinia carotovora subsp. carotovora].
It has been shown that mutants of Erwinia carotovora subsp. carotovora (ECA) resistant to mitomycin C could be characterized by the change of colonies morphology, sensitivity to bacteriocins, and by the change of pathogeneity. It is supposed that mutations responsible for the stability to mitomycin C touch the synthesis of cell membranes components. In some cases MCr-mutations caused cardinal changes--the loss of prototrophy and synthesis of carotinoid pigment. The mutants obtained in this work can be used to study the pathogenic process in Erwinia carotovora. Some of MCr- mutants are the handy indicators of carotovoricins.
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D001430:Bacteriocins / Q000378:metabolism; D004352:Drug Resistance, Microbial; D005798:Genes, Bacterial; D016685:Mitomycin / Q000494:pharmacology*; D009154:Mutation; D016973:Pectobacterium carotovorum / Q000187:drug effects* / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity
D001430:Bacteriocins; D016685:Mitomycin