title: [Effect of Acanthopanax senticosus injection on the activities of human tumor necrosis factor and natural killer cell in blood in the patients with lung cancer].
abstract: OBJECTIVE
  To study the effect of Acanthopanax senticosus injection (ASI) on the activities of human tumor necrosis factor (TNF) and natural killer cell (NKC) in the patients with lung cancer and the underlying mechanism.
  
  
  METHODS
  73 cases with lung cancer were randomly divided into two groups, namely, the treatment group (n = 39) and observation group (n = 34); 61 cases with or without other diseases were respectively divided into control A (n = 30) and B (n = 31) groups. The patients in treatment group were injected with ASI for 21 days. The activities of human TNF and NKC and the levels of IgG, IgA and IgM were detected respectively.
  
  
  RESULTS
  After injection with ASI the activity of TNF-alpha in treatment group was comparable with that in the two control groups and was significant lower that that in observation group. The activity of TNF-beta and the levels of IgA, IgG and IgM were significantly higher than those in observation group and two control groups (P < 0.01). The activity of NKC was also remarkably higher than observation and two control groups.
  
  
  CONCLUSIONS
  ASI can regulate the cellular immunity and factor, indicating that ASI can be used as an assistant drug to regulate the function of cellular immunity in the patients with lung cancer.
authors: Department of Pharmacology, Hubei Institute for Nationalities, Enshi 445000, China.
authors: De-Bin
authors: DB
authors: Huang
authors: Rui-Zhi
authors: RZ
authors: Ran
authors: Zhao-Fen
authors: ZF
authors: Yu
mesh_terms: D000328:Adult; D000368:Aged; D028001:Eleutherococcus / Q000737:chemistry; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007132:Immunoglobulin Isotypes / Q000097:blood; D007262:Infusions, Intravenous; D007694:Killer Cells, Natural / Q000187:drug effects*; D008175:Lung Neoplasms / Q000097:blood / Q000276:immunology / Q000473:pathology*; D008233:Lymphotoxin-alpha / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010946:Plants, Medicinal / Q000737:chemistry; D011134:Polysaccharides / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D007132:Immunoglobulin Isotypes; D008233:Lymphotoxin-alpha; D011134:Polysaccharides; D014409:Tumor Necrosis Factor-alpha