Potential role of growth factors in diminishing radiation therapy neural tissue injury.
Human growth factors are firmly established in treatment of cytopenias that are associated with cancer chemotherapy, and have been used successfully to reduce severe mucositis in patients receiving radiation therapy and chemotherapy in the setting of autologous bone marrow transplantation. The ability of growth factors that are involved in differentiation and proliferation of neural tissue cells to prevent or accelerate recovery from radiation injury currently is being evaluated in preclinical studies. Data from these studies indicate that brief therapeutic intervention with platelet-derived growth factor, insulin-like growth factor-1, vascular endothelial growth factor, and the combination of insulin-like growth factor-1 and basic fibroblast growth factor can prevent or delay radiation myelopathy after spinal cord irradiation. Additional investigation is required to define potentially clinically useful growth factor regimens in the clinic.
Andratschke
Nicolaus H
NH
Department of Radiation Oncology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Nieder
Carsten
C
Price
Roger E
RE
Rivera
Belinda
B
Ang
K Kian
KK
D000818:Animals; D004353:Drug Evaluation, Preclinical; D051523:Fibroblast Growth Factor 7; D005346:Fibroblast Growth Factors / Q000494:pharmacology / Q000627:therapeutic use; D006133:Growth Substances / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology / Q000627:therapeutic use; D011832:Radiation Injuries / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D011878:Radiotherapy / Q000009:adverse effects; D013116:Spinal Cord / Q000187:drug effects* / Q000528:radiation effects*; D013118:Spinal Cord Diseases / Q000209:etiology* / Q000517:prevention & control*; D042461:Vascular Endothelial Growth Factor A / Q000494:pharmacology / Q000627:therapeutic use
C496453:FGF7 protein, human; D006133:Growth Substances; D010982:Platelet-Derived Growth Factor; D011837:Radiation-Protective Agents; D042461:Vascular Endothelial Growth Factor A; D051523:Fibroblast Growth Factor 7; D005346:Fibroblast Growth Factors