Granulocytic sarcoma of the spine in a child without bone marrow involvement: a case report and literature review.
We report a 2-year-old Japanese boy without bone marrow involvement who developed a primary granulocytic sarcoma in his spinal canal. Tumour cells were positive for myeloperoxidase, MIC2, CD56 and, CD68 on formalin-fixed, paraffin-embedded tissue sections and CD13, CD33, CD45, and CD64 on acetone-fixed fresh frozen sections. Nine months after the initiation of treatment, the tumour had significantly regressed and the patient was able to walk with help.


CONCLUSIONS
Our patient is the youngest case of granulocytic sarcoma of the spine without bone marrow involvement. Immunohistochemical methods are very helpful in establishing a diagnosis of granulocytic sarcoma.
Shiozawa
Yusuke
Y
Department of Paediatrics, Juntendo University School of Medicine, Tokyo, Japan. y-shio@mte.biglobe.ne.jp
Kiyokawa
Nobutaka
N
Saito
Masahiro
M
Fujimoto
Junichiro
J
Hata
Jun-Ichi
J
Yamashiro
Yuichiro
Y
D000071443:12E7 Antigen; D015703:Antigens, CD / Q000378:metabolism; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002675:Child, Preschool; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D009195:Peroxidase / Q000378:metabolism; D023981:Sarcoma, Myeloid / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism; D013120:Spinal Cord Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism
D000071443:12E7 Antigen; D015703:Antigens, CD; D014408:Biomarkers, Tumor; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules; D009195:Peroxidase