Effect of insulin on NO production by monocytes from patients with metabolic cardiovascular syndrome.
Basal and insulin-induced production of NO by monocytes significantly increased in patients with metabolic cardiovascular syndrome. Plasma insulin concentration in these patients was below the control. No intergroup differences were found in C-peptide concentration. A negative correlation was revealed between insulin-induced NO production by monocytes and C-peptide/insulin ratio in patients. The role of monocytes on the regulation of vascular tone via NO production in patients with metabolic cardiovascular syndrome is discussed.
Suslova
T E
TE
Institute of Cardiology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences; Siberian State Medical University, Tomsk, Russia. liv@cardio.tsu.ru
Sitozhevskii
A V
AV
Ogurkova
O N
ON
Gruzdeva
O V
OV
Fedorova
T S
TS
Karpov
R S
RS
D006801:Humans; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism*; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism*; D009569:Nitric Oxide / Q000096:biosynthesis*
D007328:Insulin; D009569:Nitric Oxide