title: Pegylated liposomal doxorubicin in stage IVB mycosis fungoides.
abstract: BACKGROUND
  Previous studies have shown that pegylated liposomal doxorubicin (LD) is effective in the treatment of relapsing or recalcitrant cutaneous T-cell lymphoma.
  
  
  OBJECTIVE
  To evaluate the activity and toxicity of LD in patients with stage IVB mycosis fungoides (MF).
  
  
  METHODS
  In this retrospective study, we evaluated outcomes and recorded adverse effects in 10 patients with MF (seven men and three women) with extracutaneous involvement. Patients were treated with LD 20 mg m(-2) administered intravenously every 4 weeks.
  
  
  RESULTS
  All patients received at least two cycles of LD, three patients received four cycles and one patient received six cycles. Three patients (30%) had a partial response and two patients had stable disease. Grade 1-2 leucopenia occurred in three of the 10 patients, and grade 4 leucopenia in one. Three patients had grade 2 palmoplantar erythrodysaesthesia.
  
  
  CONCLUSIONS
  This study demonstrates that LD is beneficial in terms of activity and toxicity in stage IVB MF. These observations should be verified in larger studies.
authors: Dipartimento di Patologia Sistematica, Clinica Dermatologica, Università di Napoli Federico II, Naples, Italy. giuseppedilorenzoncol@hotmail.com
authors: G
authors: G
authors: Di Lorenzo
authors: R
authors: R
authors: Di Trolio
authors: M
authors: M
authors: Delfino
authors: S
authors: S
authors: De Placido
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004317:Doxorubicin / Q000009:adverse effects / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D009367:Neoplasm Staging; D011092:Polyethylene Glycols; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D011092:Polyethylene Glycols; D004317:Doxorubicin