The role of anterior cingulate cortex and precuneus in the coordination of motor behaviour.
Behavioral studies in humans have shown that bimanual coordination imposes specific demands on the central nervous system that exceed unimanual task control. In the present study we used functional magnetic resonance imaging to investigate the neural correlate of this additional coordination effort, i.e. regions responding more strongly to bimanual movements than inferred from summing up the responses to the unimanual subtasks. Subjects were scanned while performing movements along different directions, either uni- or bimanually. During the bimanual condition, trajectories of movement of the left and right hand were spatially incompatible, such that additional effort was required to break away from intrinsically favored mirror-movements and to integrate movements of both limbs into a new spatial pattern. Our main finding was that the execution of spatially complex bimanual coordination as compared with the unimanual subtasks activated the anterior cingulate cortex (posterior part) as well as the dorso-anterior precuneus. We hypothesize that the anterior cingulate exerts its modulatory effect on other motor areas, such as the primary motor cortex and the supplementary motor area, in order to suppress intrinsically favored coordination tendencies. Conversely, the precuneus is likely to be involved in shifting attention between different locations in space, which was necessary for monitoring the trajectories of the left and right wrist when both limbs moved in parallel. Our findings suggest that the coordination effort during bimanual and perhaps other modes of coordinated behavior is mediated by regions contributing to higher order functions, which form an interface between cognition and action.
Wenderoth
Nicole
N
Motor Control Laboratory, Group Biomedical Sciences, K.U.Leuven, Tervuursevest 101, 3001 Heverlee, Belgium. nicole.wenderoth@faber.kuleuven.be
Debaere
Filiep
F
Sunaert
Stefan
S
Swinnen
Stephan P
SP
D000328:Adult; D001931:Brain Mapping; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006179:Gyrus Cinguli / Q000033:anatomy & histology / Q000502:physiology*; D006225:Hand / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009044:Motor Cortex / Q000033:anatomy & histology / Q000502:physiology; D009068:Movement / Q000502:physiology*; D009415:Nerve Net / Q000033:anatomy & histology / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D009483:Neuropsychological Tests; D009949:Orientation / Q000502:physiology; D010296:Parietal Lobe / Q000033:anatomy & histology / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology*; D013028:Space Perception / Q000502:physiology