title: Gamibojungikki-tang decreases immobility time on the forced swimming test and increases interferon-gamma production from MOLT-4 cells.
abstract: Gamibojungikki-tang (GBIT) has been used for the purpose of development of physical strength in Korea. We investigated the anti-immobility effect of GBIT on the forced swimming test (FST) and then measured the blood biochemical parameters related to fatigue, glucose (Glc); blood urea nitrogen (BUN); lactic dehydrogenase (LDH); creatine kinase (CK) and total protein (TP). GBIT (0.01, 0.1, 1 g/kg) was orally administered to mice for 7 days. After 7 days, the immobility time was significantly decreased in the GBIT-administration group (105.0+/-12.1 s for 1 g/kg) in comparison with the control group (152.3+/-16.2 s). The contents of Glc and TP in the blood serum were significantly increased in GBIT-administration group (1g/kg) compared with control group, while LDH was significantly decreased. Surface phenotyping of spleen cells by FACS analysis revealed an increasing tendency of CD4+ and CD8+ number, without statistical significance. In addition, GBIT (0.01-1 mg/ml) increased the interferon-gamma and interlukin-2 levels in MOLT-4 T-cells. These results suggest that GBIT may be useful in the immune function improvement.
authors: College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University, 1 Hoegi-Dong, Dongdaemun-Gu, Seoul 130-701, South Korea.
authors: Hye-Young
authors: HY
authors: Shin
authors: Sung-Joo
authors: SJ
authors: Park
authors: Sang-Wan
authors: SW
authors: Seo
authors: Seung-Heon
authors: SH
authors: Hong
authors: Jae-Young
authors: JY
authors: Um
authors: Sang Hun
authors: SH
authors: Lee
authors: Si-Hyeong
authors: SH
authors: Lee
authors: Jo-Young
authors: JY
authors: Shin
authors: Tae-Yong
authors: TY
authors: Shin
authors: Young-Sig
authors: YS
authors: Park
authors: Deok-Chun
authors: DC
authors: Yang
authors: Hyung-Min
authors: HM
authors: Kim
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects; D002460:Cell Line; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D007723:Korea; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D013550:Swimming
chemical_list: D007376:Interleukin-2; D010936:Plant Extracts; D015847:Interleukin-4; D007371:Interferon-gamma