Identification of an HLA-B*07 allele variant (B*0740) in the Chinese Han population.
A novel HLA-B*07 allele, B*0740, has been identified by sequence-based typing (SBT) in the Chinese Han population. This new allele is identical to B*0705 and B*0706 for exons 2, 3, and 4, except for a single nucleotide at position 605 of codon 202 in exon 3 (AAG-->ATG) leading to an amino acid change from lysine to methionine. SBT was performed following allele separation using the Haploprep method. The serological equivalence of B*0740 to the B7 antigen did not change.
Wang
C Y
CY
The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiang Su Province, P.R. China.
Pan
Q
Q
Xue
M
M
Miao
K R
KR
Fei
X M
XM
Zhou
X Y
XY
Zhao
X
X
Kukuruga
D
D
Osowski
L
L
Poore
B
B
Beattie
R
R
Shi
W X
WX
Zhang
H
H
D000483:Alleles; D000595:Amino Acid Sequence; D044466:Asian People; D001483:Base Sequence; D005091:Exons; D014644:Genetic Variation; D015235:HLA-B Antigens / Q000235:genetics*; D015793:HLA-B7 Antigen; D006684:HLA-DR Antigens / Q000235:genetics / Q000276:immunology; D059811:HLA-DRB1 Chains; D006650:Histocompatibility Testing; D006801:Humans; D008969:Molecular Sequence Data; D017354:Point Mutation
D015235:HLA-B Antigens; C425023:HLA-B*07 antigen; D015793:HLA-B7 Antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains