Interleukin-13 (IL-13) pathway.
Interleukin-13 (IL-13), like IL-4, is a cytokine produced by T(H)2 type helper T cells in response to signaling through the T cell antigen receptor and by mast cells and basophils upon cross-linkage of the high-affinity receptor for immunoglobulin E (IgE). It is also produced by activated eosinophils. IL-13 induces many of the same responses as IL-4 and shares a receptor subunit with IL-4. IL-13 has been implicated in airway hypersensitivity and mucus hypersecretion, inflammatory bowel disease, and parasitic nematode expulsion.
Kelly-Welch
Ann
A
Program in Oncology, Marlene and Stewart Greenebaum Cancer Center and Department of Microbiology and Immunology, University of Maryland, Baltimore, USA.
Hanson
Erica M
EM
Keegan
Achsah D
AD
D000818:Animals; D019281:Dimerization; D006801:Humans; D018793:Interleukin-13 / Q000494:pharmacology / Q000502:physiology*; D053661:Interleukin-13 Receptor alpha1 Subunit; D008954:Models, Biological; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D018123:Receptors, Interleukin / Q000737:chemistry / Q000187:drug effects / Q000502:physiology; D053660:Receptors, Interleukin-13; D019948:Receptors, Interleukin-4 / Q000737:chemistry / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*
C508181:IL13RA1 protein, human; D018793:Interleukin-13; D053661:Interleukin-13 Receptor alpha1 Subunit; D018123:Receptors, Interleukin; D053660:Receptors, Interleukin-13; D019948:Receptors, Interleukin-4; D011505:Protein-Tyrosine Kinases