Proton magnetic resonance spectroscopy and magnetoencephalographic estimation of delta dipole density: a combination of techniques that may contribute to the diagnosis of Alzheimer's disease.
Whole-head magnetoencephalographic recordings were obtained from 10 patients with Alzheimer's disease (AD) and 10 healthy controls in a resting position. Spectroscopic examinations were performed by means of a 1.5-tesla whole-body scanner in the temporoparietal regions of both hemispheres. The relationship between (1)H-MRS-based and magnetoencephalography (MEG)-based measures and their conjoined capability to improve the diagnosis of AD were investigated in this study. Logistic regression analyses were performed. Three separated logistic models were calculated for (1)H-MRS-based metabolites, low-frequency magnetic activity, and the combination of both measures. A combined myoinositol/N-acetyl aspartate (mI/NAA)-delta dipole density (DD) model predicted the diagnosis with 90% sensitivity and 100% specificity. Additionally, the combination of temporoparietal mI/NAA and delta DD values explained the variability of individuals' cognitive status. The results support the notion that a multidisciplinary approach may improve the understanding and diagnosis of AD.
Fernández
Alberto
A
Centro de Magnetoencefalografía Dr. Pérez-Modrego, Universidad Complutense de Madrid, Madrid, Spain.
García-Segura
Juan Manuel
JM
Ortiz
Tomás
T
Montoya
Julia
J
Maestú
Fernando
F
Gil-Gregorio
Pedro
P
Campo
Pablo
P
Viaño
Juan
J
D000117:Acetylglucosamine / Q000378:metabolism; D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000378:metabolism; D001923:Brain Chemistry; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D007294:Inositol / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged; D010725:Phosphocreatine / Q000378:metabolism; D012044:Regression Analysis
D010725:Phosphocreatine; D018698:Glutamic Acid; D007294:Inositol; D003401:Creatine; D002794:Choline; D000117:Acetylglucosamine