Intravenous aminophylline provides no additional renal protection in patient with severe atherosclerotic renal artery stenosis treated by delicate percutaneous renal intervention.
BACKGROUND
Clinical trials on contrast-induced nephropathy (CIN) prevention with different approaches generated various results. In this study, we investigated whether intravenous aminophylline preceding percutaneous transluminal renal artery stenting (PTRS) might provide better renal protection.


METHODS
Patients with severe atherosclerotic renal artery stenosis and undergoing PTRS were prospectively studied. Intravenous aminophylline 250 mg was administered 30 min before PTRS.


RESULTS
The aminophylline group included 15 patients (mean age, 68+/-4 years) and the case-matched control group consisted of another 15 patients (mean age, 71+/-2 years). After a mean follow-up of 5-6 months, both groups showed similar serum creatinine (1.7+/-0.2 vs. 1.6+/-0.1 mg/dl, P=NS), BUN (20.0+/-3.0 vs. 24.0+/-3.0 mg/dl, P=NS), fall in systolic (-15+/-13 vs. -11+/-3 mm Hg, P=NS) and diastolic BP (-2+/-4 vs. -6+/-5 mm Hg, P=NS). The incidence of post-operative renal deterioration was 6.7% in the study group and none in the control group.


CONCLUSIONS
Pre-treatment intravenous aminophylline provides no additional renal protective effect in delicately practiced PTRS.
Tsao
Chen-Rong
CR
Liu
Tsun-Jui
TJ
Chen
Fu-Chung
FC
Chu
Yong-Hua
YH
Her
Hong-Yun
HY
Lin
Wei-Wen
WW
Wang
Kuo-Yang
KY
Chen
Ying-Tsung
YT
Ting
Chih-Tai
CT
Lee
Wen-Lieng
WL
D000368:Aged; D000628:Aminophylline / Q000008:administration & dosage*; D000800:Angioplasty, Balloon; D001161:Arteriosclerosis / Q000628:therapy*; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D011446:Prospective Studies; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging / Q000628:therapy*; D015607:Stents; D014463:Ultrasonography
D002316:Cardiotonic Agents; D000628:Aminophylline