Enantioselective total synthesis of bioactive natural product (+)-Sch 642305: a structurally novel inhibitor of bacterial DNA primase and HIV-1 Tat transactivation.
The total synthesis of the bioactive natural product (+)-Sch 642305 has been achieved from a readily available chiral building block using an RCM protocol to construct the key decalactone moiety; our approach is notable for its built-in flexibility and is diversity oriented.
Mehta
Goverdhan
G
Department of Organic Chemistry, Indian Institute of Science, Bangalore, India. gm@orgchem.iisc.ernet.in
Shinde
Harish M
HM
D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D019915:DNA Primase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004269:DNA, Bacterial / Q000235:genetics; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D015696:Gene Products, tat / Q000378:metabolism*; D015497:HIV-1 / Q000235:genetics* / Q000378:metabolism; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D013237:Stereoisomerism; D015533:Transcriptional Activation / Q000187:drug effects*; D054322:tat Gene Products, Human Immunodeficiency Virus
D001688:Biological Products; D004269:DNA, Bacterial; D004791:Enzyme Inhibitors; D015696:Gene Products, tat; D018942:Macrolides; C482741:Sch 642305; D054322:tat Gene Products, Human Immunodeficiency Virus; D019915:DNA Primase