Changes in the beta-endorphin plasma level after repeated treatment with acamprosate in rats selectively bred for high and low alcohol preference.
The aim of this study was to evaluate the beta-endorphin (beta-endorphin) plasma level in Warsaw Low Preferring (WLP) and Warsaw high-preferring (WHP) rats after repeated administration of acamprosate, one of most effective drug in the treatment of alcoholism. Treatment with acamprosate in dose 200mg/kg, p.o. for 10 days induced an increase in plasma beta-endorphin levels. A single injection of ethanol also results in the increase of beta-endorphin level. Moreover, it was found that single injection of ethanol to WHP rats resulted in lower increase of plasma beta-endorphin content in rats earlier treated with acamprosate. In WLP rats, repeated acamprosate treatment prevents the ethanol-induced increase in plasma beta-endorphin level. It may be concluded that acamprosate modulates the endogenous opioid system.
Zalewska-Kaszubska
Jadwiga
J
Department of Pharmacodynamics, Medical University of Łódź, Muszyńskiego 1, PL 90-151 Łódź, Poland. jzalewska@pharm.am.lodz.pl
Cwiek
Wojciech
W
Dyr
Wanda
W
Czarnecka
Elzbieta
E
D000077443:Acamprosate; D000427:Alcohol Deterrents / Q000008:administration & dosage / Q000627:therapeutic use; D020268:Alcohol-Induced Disorders, Nervous System / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D000437:Alcoholism / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D004347:Drug Interactions / Q000502:physiology; D000431:Ethanol / Q000037:antagonists & inhibitors; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D018847:Opioid Peptides / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D013654:Taurine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome; D015854:Up-Regulation / Q000187:drug effects / Q000502:physiology; D001615:beta-Endorphin / Q000097:blood* / Q000187:drug effects*
D000427:Alcohol Deterrents; D018847:Opioid Peptides; D013654:Taurine; D000431:Ethanol; D001615:beta-Endorphin; D000077443:Acamprosate