title: Synthesis of water-soluble, multiple functionalizable dendrons for the conversion of large dendrimers or other molecular objects into potential drug carriers.
abstract: The synthesis of dendrons and dendrimers which carry OEG chains and bidentate ligands and/or fluorescence tags is described. The orthogonally protected functional groups of the dendrons allow modification of the substitution pattern and attachment to larger entities. Both dendrons and dendrimers are highly water-soluble. The dendrons should have considerable potential to convert, for example, commercially available, high-generation dendrimers into water-soluble, versatile support materials for antitumor therapy.
authors: Institut für Chemie/Organische Chemie, Freie Universität Berlin, Takustrasse 3, 14195 Berlin, Germany.
authors: Stephan
authors: S
authors: Müller
authors: A Dieter
authors: AD
authors: Schlüter
mesh_terms: D000873:Anthracenes / Q000737:chemistry*; D004337:Drug Carriers; D009682:Magnetic Resonance Spectroscopy; D012995:Solubility; D021241:Spectrometry, Mass, Electrospray Ionization; D014867:Water / Q000737:chemistry*
chemical_list: D000873:Anthracenes; D004337:Drug Carriers; C501244:dendron; D014867:Water