title: Formation of supramolecular aggregations of gamma-globulin as a metal-dependent process.
abstract: The presence of copper cations in the solution of human serum gamma-globulin induced the formation of supramolecular forms of the protein. The intensity of this reaction increased with increasing copper concentration. The mechanisms of g-globulin aggregate formation under normal conditions and the possible role of bivalent metal cations in the regulation of protein effector functions are discussed.
authors: Laboratory of Cell-Cell Interactions, N. F. Gamaleya Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow. cheknev@riem.ru
authors: S B
authors: SB
authors: Cheknev
authors: E E
authors: EE
authors: Babaeva
authors: M S
authors: MS
authors: Zharkova
authors: A A
authors: AA
authors: Poroshina
authors: U A
authors: UA
authors: Vorob'yova
mesh_terms: D002413:Cations, Divalent / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D019327:Copper Sulfate / Q000737:chemistry*; D006801:Humans; D012996:Solutions / Q000737:chemistry; D005719:gamma-Globulins / Q000737:chemistry*
chemical_list: D002413:Cations, Divalent; D012996:Solutions; D005719:gamma-Globulins; D003300:Copper; D019327:Copper Sulfate