Contact vitiligo following a strong patch test reaction to triglycidyl-p-aminophenol in an aircraft industry worker: case report and review of the literature.
Epoxy resin systems (ERSs) are a frequent cause of occupational allergic contact dermatitis. A 50-year-old patient developed eczematous skin lesions on the back of his hands, lower arms and eye lids, 2 months after he had started working in aircraft construction. Patch tests showed positive reactions at day 3 to nickel sulfate, epoxy resin based on diglycidyl ether of bisphenol F (DGEBF) and 1,4-butanediol diglycidyl ether (1,4-BDDGE). The chemical triglycidyl-p-aminophenol (TGPAP) applied at 1% and 0.1% induced the strongest (+++ positive) reaction. About 4 months after the patch test with TGPAP, the patient presented with 2 circular depigmented spots in the former TGPAP-patch test areas. Dermatohistopathology confirmed the diagnosis of contact vitiligo.
Jappe
U
U
Department of Dermatology and Venereology, University of Heidelberg, Heidelberg, Germany. uta_jappe@med.uni-heidelberg.de
Geier
J
J
Hausen
B M
BM
D000401:Aircraft; D000627:Aminophenols / Q000633:toxicity*; D009783:Dermatitis, Occupational / Q000209:etiology*; D004852:Epoxy Compounds / Q000633:toxicity*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D014820:Vitiligo / Q000139:chemically induced*
D000627:Aminophenols; D004852:Epoxy Compounds; C414224:triglycidyl-p-aminophenol