title: Concise syntheses of (+)-macrosphelides A and B.
abstract: [reaction: see text]. Unified and highly convergent total syntheses of (+)-macrosphelides A and B are described. Key features of the syntheses include (1) concise synthesis of the optically active delta-hydroxy-gamma-keto alpha,beta-unsaturated acid fragment via the direct addition of a trans-vinylogous ester anion equivalent to the readily available Weinreb amide and (2) facile construction of the 16-membered macrolide core of the macrosphelide series via an intramolecular nitrile-oxide cycloaddition (INOC).
authors: College of Pharmacy, Seoul National University, Korea.
authors: Seung-Mann
authors: SM
authors: Paek
authors: Seung-Yong
authors: SY
authors: Seo
authors: Seok-Ho
authors: SH
authors: Kim
authors: Jong-Wha
authors: JW
authors: Jung
authors: Yong-Sil
authors: YS
authors: Lee
authors: Jae-Kyung
authors: JK
authors: Jung
authors: Young-Ger
authors: YG
authors: Suh
mesh_terms: D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis; D018942:Macrolides / Q000138:chemical synthesis*; D003904:Mitosporic Fungi / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D006571:Heterocyclic Compounds; D018942:Macrolides; C097798:macrosphelide A; C097799:macrosphelide B