Topical streptococcal preparation, OK-432, for atopic dermatitis.
Effective treatment of atopic dermatitis (AD) may in some cases prove quite difficult. OK-432, prepared from the penicillin-treated Su strain of type III Group A Streptococcus pyogenes, has been shown to be effective for treating not only cancer but verruca vulgaris as well, suggesting this agent to create the Th1 pathway through IL-12 induction. Four AD patients consented to trial use of the OK-432 ointment. OK-432 was found to bring about complete cure in the present four cases. Based on results from its use, OK-432 may be concluded to be highly effective for treating AD.
Horiuchi
Y
Y
Division of Dermatology, Tsukuba Memorial Hospital, Tsukuba City, Ibaraki, Japan. nu-yhori@jcom.home.ne.jp
D000287:Administration, Topical; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D009824:Ointments; D010844:Picibanil / Q000008:administration & dosage / Q000627:therapeutic use*
D009824:Ointments; D010844:Picibanil