title: Chronic myeloid leukemia presenting with extramedullary disease as massive ascites responding to imatinib mesylate.
abstract: Patients with chronic myeloid leukemia (CML) can develop extramedullary involvement during the course of the illness. This usually occurs during the accelerated phase or blast crisis. We describe a patient who presented with massive ascites probably due to mesenteric/peritoneal infiltration during chronic phase CML. There was an excellent response to imatinib with a complete cytogenetic response and total disappearance of ascites.
authors: Department of Medicine, Hematology/Oncology Division, King Khalid University Hospital, Riyadh, Saudi Arabia. aameraleem@hotmail.com
authors: Aamer
authors: A
authors: Aleem
authors: Neelam
authors: N
authors: Siddiqui
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001201:Ascites / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D001549:Benzamides; D001752:Blast Crisis / Q000235:genetics*; D020732:Cytogenetic Analysis; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D012074:Remission Induction
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D016044:Fusion Proteins, bcr-abl