Social cues shift functional connectivity in the hypothalamus.
We determined how social stimuli that vary in behavioral relevance differentially activate functional networks in the frog hypothalamus. As measured by egr-1 mRNA levels, activity in three hypothalamic nuclei varied with acoustic stimulus, and these responses were correlated with egr-1 responses in different auditory regions regardless of stimulus. The correlations among hypothalamic nuclei, however, varied as a function of the behavioral relevance of the stimuli. Thus relevant social cues shift the functional connectivity within the hypothalamus, consistent with principles that underlie the simultaneous processing of sensory information in cognitive tasks.
Hoke
Kim L
KL
Section of Integrative Biology, University of Texas, 1 University Station C0930, Austin, TX 78712, USA. khoke@psych.stanford.edu
Ryan
Michael J
MJ
Wilczynski
Walter
W
D000161:Acoustic Stimulation; D000704:Analysis of Variance; D000818:Animals; D001001:Anura / Q000502:physiology*; D003463:Cues; D051766:Early Growth Response Protein 1 / Q000378:metabolism*; D005260:Female; D007031:Hypothalamus / Q000166:cytology / Q000502:physiology*; D017403:In Situ Hybridization; D009473:Neuronal Plasticity / Q000502:physiology*; D010176:Panama; D012726:Sexual Behavior, Animal / Q000502:physiology; D012931:Social Environment; D014828:Vocalization, Animal / Q000502:physiology
D051766:Early Growth Response Protein 1