[The effects of zhubi capsule on adjuvant arthritis in rats].
OBJECTIVE
To explore the therapeutic effects and mechanisms of Zhubi capsule on adjuvant arthritis (AA) in rats.


METHODS
The model of rat was induced by intradermal injection of CFA. The perimeter of ankle joint was measured at different time points. Con A-induced splencyte proliferation was examined by MIT assay and the expression of IL-1, IL-6 in synovium was determined by immunohistochemical method.


RESULTS
After the preventive administration of Zhubi capsule (5.2, 2.6, 1.3 g x kg x d(-1), x 25 d), it was found that Zhubi capsule significantly inhibited the primary and secondary ankle joint swelling. The increased Con A-induced splencyte proliferation reaction and the activated IL1, IL-6 expression of AA rat were suppressed by the treatment with Zhubi capsule.


CONCLUSIONS
Zhubi capsule has a therapeutic effect on AA rats, and its mechanism is related to the immunoregulative function.
Li
Hui
H
Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700, China. huiwli@sina.com
Jin
Ya-hong
YH
Yuan
Gui-dong
GD
Wang
Su-fen
SF
D000818:Animals; D000843:Ankle Joint / Q000473:pathology*; D001169:Arthritis, Experimental / Q000378:metabolism / Q000473:pathology; D002214:Capsules; D049109:Cell Proliferation / Q000187:drug effects; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D007375:Interleukin-1 / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D008419:Materia Medica / Q000008:administration & dosage / Q000494:pharmacology*; D008560:Membrane Fluidity / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000166:cytology; D013583:Synovial Membrane / Q000187:drug effects
D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D007375:Interleukin-1; D015850:Interleukin-6; D008419:Materia Medica