Granulocytic sarcoma of the heart: extramedullary relapse of acute myeloblastic leukemia after allogeneic stem cell transplantation successfully treated by chemotherapy alone.
We present a case of granulocytic sarcoma (GS) of the heart. A 28-year-old man with relapsed acute myelogenous leukemia (AML-M2) had undergone a non-myeloablative allogeneic peripheral stem cell transplantation. Three years following transplantation, masses were evidenced in his heart by echocardiography but had completely disappeared following a common chemotherapy etoposide, mitoxantrone, ara-C (EMA) regimen for relapsed AML. The involvement of the heart with GS is very rare and this is the first case of extramedullary disease in the heart after allogeneic transplantation. Here we present the case history and related literature has been reviewed.
Kara
Ismail Oguz
IO
Department of Medical Oncology, Cukurova University Faculty of Medicine, Yuregir, Adana, Turkey. iokara@cu.edu.tr
Sahin
Berksoy
B
Paydas
Semra
S
Kara
Banu
B
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003561:Cytarabine / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D006338:Heart Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000628:therapy*; D008297:Male; D008942:Mitoxantrone / Q000008:administration & dosage; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D012074:Remission Induction; D023981:Sarcoma, Myeloid / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D014184:Transplantation, Homologous
D003561:Cytarabine; D005047:Etoposide; D008942:Mitoxantrone