Anti-androgenic activities of Ganoderma lucidum.
The inhibitory effects of methanol extracts of 19 edible and medicinal mushrooms on 5alpha-reductase activity were examined. The extract of Ganoderma lucidum Fr. Krast (Ganodermataceae) showed the strongest 5alpha-reductase inhibitory activity. The treatment of the fruit body of Ganoderma lucidum or the extract prepared from it significantly inhibited the testosterone-induced growth of the ventral prostate in castrated rats. These results showed that Ganoderma lucidum might be a useful ingredient for the treatment of benign prostatic hyperplasia (BPH).
Fujita
Rumi
R
Department of Forest and Forest Products Science, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan.
Liu
Jie
J
Shimizu
Kuniyoshi
K
Konishi
Fumiko
F
Noda
Kiyoshi
K
Kumamoto
Shoichiro
S
Ueda
Chie
C
Tajiri
Hisatoshi
H
Kaneko
Shuhei
S
Suimi
Yoshitaro
Y
Kondo
Ryuichiro
R
D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D042944:Cholestenone 5 alpha-Reductase / Q000037:antagonists & inhibitors; D005260:Female; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D011467:Prostate / Q000187:drug effects / Q000254:growth & development; D011470:Prostatic Hyperplasia / Q000188:drug therapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D020940:Reishi
D000726:Androgen Antagonists; D010936:Plant Extracts; D042944:Cholestenone 5 alpha-Reductase