title: Tolerance and efficacy of combined diethylcarbamazine and albendazole for treatment of Wuchereria bancrofti and intestinal helminth infections in Haitian children.
abstract: This randomized, placebo-controlled trial investigated the tolerance, efficacy, and nutritional benefit of combining chemotherapeutic treatment of intestinal helminths and lymphatic filariasis. Children were infected with Ascaris (30.7%), Trichuris (53.4%), and hookworm (9.7%) with 69.9% having more than one of these parasites. A total of 15.8% of the children had Wuchereria bancrofti microfilariae. Children were randomly assigned treatment with placebo, albendazole (ALB), diethylcarbamazine (DEC), or combined therapy. The combination of DEC/ALB reduced microfilarial density compared with placebo, ALB, or DEC (P < or = 0.03). Albendazole and DEC/ALB reduced the prevalence of Ascaris, Trichuris, and hookworm more than placebo or DEC (P < or = 0.03). Among Trichuris-infected children, those receiving ALB and DEC/ALB demonstrated greater gains in weight compared with placebo (P < or = 0.05). Albendazole and DEC/ALB were equally efficacious in treating intestinal helminths and for children with W. bancrofti microfilaremia, DEC/ALB was more effective than DEC, with no increase in severity of adverse reactions.
authors: Epidemic Intelligence Service, Epidemiology Program Office, and Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA.
authors: Leanne M
authors: LM
authors: Fox
authors: Bruce W
authors: BW
authors: Furness
authors: Jennifer K
authors: JK
authors: Haser
authors: Dardith
authors: D
authors: Desire
authors: Jean-Marc
authors: JM
authors: Brissau
authors: Marie-Denise
authors: MD
authors: Milord
authors: Jack
authors: J
authors: Lafontant
authors: Patrick J
authors: PJ
authors: Lammie
authors: Michael J
authors: MJ
authors: Beach
mesh_terms: D015766:Albendazole / Q000627:therapeutic use*; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D002648:Child; D004049:Diethylcarbamazine / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005368:Filariasis / Q000188:drug therapy*; D006801:Humans; D014958:Wuchereria bancrofti
chemical_list: D000871:Anthelmintics; D015766:Albendazole; D004049:Diethylcarbamazine