title: Drug-resistant Neisseria gonorrhoeae in Michigan.
abstract: The increasing prevalence of quinolone-resistant Neisseria gonorrhoeae (QRNG) in the United States is a cause for concern. Detecting resistance is complicated by the widespread use of molecular tests that do not provide isolates for susceptibility testing. The Michigan Department of Community Health developed a sentinel surveillance program to detect antimicrobial drug resistance in N. gonorrhoeae. Sentinel surveillance from 11 laboratories submitted 1,122 isolates for antimicrobial drug susceptibility testing and detected 2 clusters of QRNG from January 2003 to September 2004. These clusters were epidemiologically distinct: one involved young, heterosexual youth, and the other involved older men who have sex with men. This finding led to changes in local treatment recommendations that limited spread of resistant strains. Development of the sentinel program, collection of data, and epidemiologic analysis of the clusters are discussed.
authors: Michigan Department of Community Health, Lansing, Michigan 48909, USA. macomberk@michigan.gov
authors: Kathryn E
authors: KE
authors: Macomber
authors: Martha S
authors: MS
authors: Boehme
authors: James T
authors: JT
authors: Rudrik
authors: Dara
authors: D
authors: Ganoczy
authors: Erin
authors: E
authors: Crandell-Alden
authors: William A
authors: WA
authors: Schneider
authors: Patricia A
authors: PA
authors: Somsel
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D005260:Female; D024841:Fluoroquinolones / Q000494:pharmacology; D006069:Gonorrhea / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D008297:Male; D008824:Michigan / Q000453:epidemiology; D008875:Middle Aged; D009344:Neisseria gonorrhoeae / Q000187:drug effects*; D015995:Prevalence; D018571:Sentinel Surveillance
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones