Highly stereoselective synthesis of 2,5-disubstituted 3-vinylidene tetetrahydrofurans via Prins-type cyclization.
[reaction: see text]. A novel synthetic methodology for 2,5-disubstituted tetrahydrofurans having an allenyl group at the 3-position via Prins-type cyclization was developed. The reaction led to excellent selectivity and moderate to high yields.
Shin
Chul
C
Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul.
Chavre
Satish N
SN
Pae
Ae Nim
AN
Cha
Joo Hwan
JH
Koh
Hun Yeong
HY
Chang
Moon Ho
MH
Choi
Jung Hoon
JH
Cho
Yong Seo
YS