title: [Analysis on processing mechanism of calamine].
abstract: OBJECTIVE
  To study processing method and mechanism of Calamine.
  
  
  METHODS
  Thermogravimetry analysis method and nano-technology were adopted to analyze and synthesize the components in Calamine, Tetracycline was took as the comparison drug to determine the antibacterial activity of Calamine and its components.
  
  
  RESULTS
  A part of zinc carbonate in Calamine was decomposed into zinc oxide when processing, and the particle size was smaller than before. The antibacterial activity of Calamine is decided by the content and particle size of zinc oxide, and has nothing with zinc carbonate. The more content and the smaller particle size of zinc oxide, the more powerful antibacterial activity of Calamine.
  
  
  CONCLUSIONS
  The content and the particle size of zinc oxide can be the important targets in the processing of Calamine.
authors: Peoples Hospital of Jilin Province, Changchun 130012, China.
authors: Yi-Ming
authors: YM
authors: Guo
authors: Kai-Feng
authors: KF
authors: Yu
authors: Yan-Hua
authors: YH
authors: Liu
authors: Jing-Zhe
authors: JZ
authors: Zhao
authors: Zi-Cheng
authors: ZC
authors: Wang
authors: Heng-Bin
authors: HB
authors: Zhang
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002254:Carbonates / Q000737:chemistry / Q000494:pharmacology; D004338:Drug Combinations; D004926:Escherichia coli / Q000187:drug effects; D005290:Ferric Compounds / Q000737:chemistry* / Q000494:pharmacology; D008419:Materia Medica / Q000737:chemistry / Q000494:pharmacology*; D049329:Nanostructures; D036103:Nanotechnology; D010316:Particle Size; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012475:Salmonella / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects*; D013678:Technology, Pharmaceutical / Q000379:methods*; D013752:Tetracycline / Q000494:pharmacology; D013818:Thermogravimetry; D017967:Zinc Compounds / Q000737:chemistry / Q000494:pharmacology; D015034:Zinc Oxide / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D002254:Carbonates; D004338:Drug Combinations; D005290:Ferric Compounds; D008419:Materia Medica; D017967:Zinc Compounds; C020241:calamine (pharmaceutical preparation); C036650:zinc carbonate; D013752:Tetracycline; D015034:Zinc Oxide