[Homologous dermal acellular matrix graft for urethral reconstruction in man (report of 16 cases)].
OBJECTIVE
To investigated the value of homologous dermal acellular matrix graft (AMG) for urethral reconstruction in man, and found an ideal replacement material to simplify the urethroplastic surgery.


METHODS
16 male patients, aged 18-46 (mean 26.5), with urethral diseases were treated with allograft of tissue engineering material AMG. The causes of urethroplasty were complex urethral stricture followed by pelvic fracture (13 cases), anterior urethral stricture (2 cases), hypospadia (1 case). During the operation, AMG was sutured to a tubular graft and replaced the defect urethra. A 18-22 Fr silicone catheter was inserted in the reconstructed urethra for 4-6 weeks.


RESULTS
All 16 patients were voiding well after removing the catheter, urethrography reveal excellent caliber of the reconstructed urethra. Urethroscopic examination showed the graft urethra was covered by epithelial tissue and grew into the native tissue. But stenosis was developed in 3 patients postoperatively, 1 patients received transurethral incision, another 2 needed urethral sounding. The patients were followed-up for 12-72 months (mean 45.6), no rejection was observed, all patients voided normally except 4 cases needed urethral dilatation periodically.


CONCLUSIONS
The homologous dermal acellular matrix graft may serve as an ideal replacement material for complex urethral stricture or defect, without concern of rejection.
Lin
Jian
J
Department of Urology, the First Hospital of Peking University, the Institute of Urology, Beijing 100034, China.
Hao
Jin-rui
JR
Jin
Jie
J
Deng
Shu-min
SM
Hu
Jie
J
Na
Yan-qun
YQ
D000293:Adolescent; D000328:Adult; D020405:Dermis / Q000637:transplantation*; D005109:Extracellular Matrix / Q000637:transplantation; D050723:Fractures, Bone / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D010388:Pelvis / Q000293:injuries*; D023822:Tissue Engineering; D014521:Urethra / Q000601:surgery*; D014525:Urethral Stricture / Q000209:etiology / Q000601:surgery*; D013521:Urologic Surgical Procedures, Male