title: Physiologically stable vanadium(IV) porphyrins as a new class of anti-HIV agents.
abstract: The water soluble oxovanadium(IV) tetraarylporphyrin has demonstrated excellent solution stability against glutathione reduction and high potency (5 microM, 97% inhibition) in inhibiting HIV-1 replication in Hut/CCR5 cells.
authors: Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, SAR, China.
authors: Suk-Yu
authors: SY
authors: Wong
authors: Raymond
authors: R
authors: Wai-Yin Sun
authors: Nancy P-Y
authors: NP
authors: Chung
authors: Chen-Lung
authors: CL
authors: Lin
authors: Chi-Ming
authors: CM
authors: Che
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D004355:Drug Stability; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D008665:Metalloporphyrins / Q000737:chemistry / Q000494:pharmacology*; D010084:Oxidation-Reduction; D019713:Receptors, CCR5; D012995:Solubility; D017968:Vanadium Compounds / Q000737:chemistry / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D008665:Metalloporphyrins; D019713:Receptors, CCR5; D017968:Vanadium Compounds; D005978:Glutathione