title: Multiple myeloma involving the central nervous system: a report of two cases with unusual manifestations.
abstract: We describe two patients with multiple myeloma (MM) involving the central nervous system (CNS). In both patients, CNS involvement was manifested with extremely rare signs and symptoms. The first patient, a 64-year-old woman, developed obstructive hydrocephalus 10 years after the initial diagnosis of MM. The disease has been successfully treated with intrathecal chemotherapy, radiotherapy and systemic chemotherapy. The other patient, a 65-year-old man, developed hypopituitarism and diabetes insipidus 1 year after MM diagnosis. Disease in this patient proved resistant to both radiotherapy and chemotherapy; the patient died 2 years later. These rare complications add new information on the wide spectrum of clinical and laboratory manifestations of MM. It is obvious that descriptions of additional cases are required to better understand the mechanisms of CNS involvement in MM patients.
authors: Department of Hematology, University of Crete School of Medicine, University Hospital of Heraklion, Heraklion, Crete, Greece.
authors: Charalampos
authors: C
authors: Pontikoglou
authors: Constantine
authors: C
authors: Fragos
authors: Eleftheria
authors: E
authors: Kolyvaki
authors: George
authors: G
authors: Samonis
authors: George D
authors: GD
authors: Eliopoulos
authors: Helen A
authors: HA
authors: Papadaki
mesh_terms: D000368:Aged; D003919:Diabetes Insipidus / Q000209:etiology; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology*; D007018:Hypopituitarism / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications*