title: HIV-related neurological syndromes reduce health-related quality of life.
abstract: BACKGROUND
  Human immunodeficiency virus (HIV) infection frequently results in neurological complications but the impact of different neurological syndromes on patients' quality of life remains unknown.
  
  
  METHODS
  We investigated health-related quality of life (HRQoL) parameters among HIV/Acquired Immune Deficiency Syndrome (AIDS) patients with and without neurological disease, including 11 dimensions of HRQoL within the Medical Outcomes Short-form Health Survey-HIV.
  
  
  RESULTS
  Comparisons of sociodemographic and systemic clinical variables did not differ between HIV/AIDS patients with (n=94) and without (n=75) neurological disease. However, patients with neurological diseases exhibited significantly lower HRQoL scores compared to matched controls, which was most evident among HIV/AIDS patients with cognitive impairment and sensory neuropathy. Prospective analysis revealed diminishing HRQoL scores prior to neurological diagnosis followed by a progressive and sustained improvement in HRQoL scores after intervention over a 96-week period.
  
  
  CONCLUSIONS
  These studies indicate that while HIV-related neurological diseases are associated with reduced HRQoL scores, enhanced neurological care has a positive impact on HIV/AIDS patients' overall well-being.
authors: Department of Psychiatry, University of Calgary, Calgary, AB, Canada.
authors: Rupang
authors: R
authors: Pandya
authors: Hartmut B
authors: HB
authors: Krentz
authors: M John
authors: MJ
authors: Gill
authors: Christopher
authors: C
authors: Power
mesh_terms: D015526:AIDS Dementia Complex / Q000503:physiopathology / Q000523:psychology*; D000328:Adult; D000367:Age Factors; D001927:Brain Diseases / Q000503:physiopathology / Q000523:psychology* / Q000821:virology; D003072:Cognition Disorders / Q000523:psychology / Q000821:virology; D003430:Cross-Sectional Studies; D018450:Disease Progression; D004522:Educational Status; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000523:psychology*; D006801:Humans; D002546:Ischemic Attack, Transient / Q000523:psychology / Q000821:virology; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000523:psychology / Q000821:virology; D009443:Neuritis / Q000523:psychology / Q000821:virology; D010523:Peripheral Nervous System Diseases / Q000523:psychology / Q000821:virology; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology*; D012640:Seizures / Q000523:psychology / Q000821:virology; D012737:Sex Factors; D011795:Surveys and Questionnaires