The reproductive performance of women with hypogonadotropic hypogonadism in an in vitro fertilization and embryo transfer program.
OBJECTIVE
To evaluate the outcome of women with hypogonadotropic hypogonadism undergoing in-vitro fertilization (IVF).


METHODS
We retrospectively assessed outcomes in 58 women with hypogonadotropic hypogonadism (HH) and, as matched controls, in 116 women with tubal factor (TF) infertility who underwent assisted reproduction treatment (ART). For ovulation induction, human menopausal gonadotropin (hMG) was used in HH patients and a combination of hMG and gonadotropin releasing hormone (GnRH) agonist was used in TF patients. Conception and implantation rates, as well as duration of stimulation and number of oocytes retrieved, were the main outcome measures.


RESULTS
Of the 58 HH patients, 53 (91.3%) responded adequately to ovulation induction and underwent ET. A larger amount of gonadotropins and a longer duration of ovarian stimulation were needed in HH patients than in TF patients. The mean number of retrieved oocytes and implantation rates did not differ between the groups. In addition, there were no differences between the HH and TF groups in pregnancy (53.8 vs. 48.6%) and multiple pregnancy (63.4 vs. 48.4%) rates. In the HH group, the miscarriage rate was 3.4%, and none of these patients developed severe OHSS.


CONCLUSIONS
IVF in HH patients, in which there was a background of previous failed ovulation induction, was as successful as in women with TF infertility.
Ulug
Ulun
U
Bahceci Women Health Care Center and German Hospital, Istanbul, Turkey.
Ben-Shlomo
Izhar
I
Tosun
Süleyman
S
Erden
Halit Firat
HF
Akman
Mehmet Ali
MA
Bahceci
Mustafa
M
D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D006062:Gonadotropins / Q000097:blood; D006801:Humans; D007006:Hypogonadism / Q000150:complications*; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies
D006062:Gonadotropins