title: Usefulness of the Plasmodium falciparum chloroquine resistance transporter T76 genotype failure index for the estimation of in vivo chloroquine resistance in Burkina Faso.
abstract: The prevalence of chloroquine (CQ) treatment failure and the genotype failure index was determined in four sentinel sites in Burkina Faso. In three sites, the genotype failure index varied between 1.7 and 3, a result confirming the relationship between the Plasmodium falciparum CQ resistance transporter (Pfcrt) T76 mutation and CQ resistance. In the remaining site, the genotype failure index was unusually low, 1.1, which was significantly different than that in the other sites (P < 0.00001). These findings are discussed. Often but not always, the prevalence of CQ resistance can be correctly estimated by the Pfcrt T76 genotype failure index.
authors: Centre Muraz/Institut de Recherche en Sciences de la Santé, Bobo Dioulasso, Burkina Faso.
authors: Halidou
authors: H
authors: Tinto
authors: Boroma
authors: B
authors: Sanou
authors: Jean-Claude
authors: JC
authors: Dujardin
authors: Jean Bosco
authors: JB
authors: Ouédraogo
authors: Chantal
authors: C
authors: VAN Overmeir
authors: Annette
authors: A
authors: Erhart
authors: Eric
authors: E
authors: VAN Marck
authors: Tinga Robert
authors: TR
authors: Guiguemdé
authors: Umberto
authors: U
authors: D'Alessandro
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D002050:Burkina Faso; D002738:Chloroquine / Q000627:therapeutic use*; D004351:Drug Resistance / Q000235:genetics*; D005838:Genotype; D009154:Mutation; D010963:Plasmodium falciparum / Q000235:genetics*; D015800:Protozoan Proteins / Q000235:genetics*
chemical_list: D000962:Antimalarials; D015800:Protozoan Proteins; D002738:Chloroquine