Case report: successful interdisciplinary treatment of cerebrally disseminated invasive pulmonal aspergillosis in a child with acute myeloid leukemia.
Invasive pulmonary aspergillosis (IPA) is a life-threatening infection in immunocompromised patients. Mortality rates of cerebrally disseminated IPA approach 100%. We report on a case of a 9-year-old girl with acute myeloid leukemia, who acquired cerebrally disseminated IPA during chemotherapy-induced leukopenia. Longtime survival was achieved by left pneumonectomy and neurosurgical resection of the intracerebral lesion combined with systemic application of itraconazole and liposomal amphotericin B. A review of literature revealed 7 other cases of cerebrally disseminated IPA with survival of more than 12 months.
Kurdow
Roland
R
Department of General Surgery and Thoracic Surgery, University Hospital of Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany. rkurdow@surgery.uni-kiel.de
Boehle
Arnd-Steffen
AS
Ankermann
Tobias
T
Schniewind
Bodo
B
Dohrmann
Peter
P
D000935:Antifungal Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000150:complications / Q000188:drug therapy / Q000209:etiology / Q000601:surgery; D002648:Child; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D007970:Leukopenia / Q000139:chemically induced; D020953:Neuroaspergillosis / Q000188:drug therapy / Q000209:etiology / Q000601:surgery*; D016896:Treatment Outcome
D000935:Antifungal Agents