title: Does circadian and seasonal variation in occurrence of acute aortic dissection influence in-hospital outcomes?
abstract: The risk of acute aortic dissection (AAD) exhibits chronobiological variations with peak onset in the morning and in winter. However, it is not known whether the time of day or season of the year of the AAD affects clinical outcomes. We studied 1,032 patients enrolled in the International Registry of Acute Aortic Dissection from January 1997 to December 2001. For circadian and seasonal analysis, the time and date of symptom onset were available for 741 and 1,007 patients, respectively, and were grouped into four 6h periods (morning, afternoon, evening, and night) and four seasons (winter, spring, summer, and autumn). The chi2 test for goodness of fit was used to evaluate non-uniformity of the time of day and time of year for critical in-hospital clinical events, including death. While highest incidence of AAD occurred in the morning and winter, clinical events (including mortality) were similar during the four different periods of the 24 h (chi2 = 1.9, p = 0.60) and seasonal (chi2 = 1.2, p = 0.75) periods.
authors: Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA. mehta007@dcri.duke.edu
authors: Rajendra H
authors: RH
authors: Mehta
authors: Roberto
authors: R
authors: Manfredini
authors: Eduardo
authors: E
authors: Bossone
authors: Stuart
authors: S
authors: Hutchison
authors: Arturo
authors: A
authors: Evangelista
authors: Benedetta
authors: B
authors: Boari
authors: Jeanna V
authors: JV
authors: Cooper
authors: Dean E
authors: DE
authors: Smith
authors: Patrick T
authors: PT
authors: O'Gara
authors: Dan
authors: D
authors: Gilon
authors: Linda A
authors: LA
authors: Pape
authors: Christoph A
authors: CA
authors: Nienaber
authors: Eric M
authors: EM
authors: Isselbacher
authors: Kim A
authors: KA
authors: Eagle
mesh_terms: D000368:Aged; D000784:Aortic Dissection / Q000473:pathology* / Q000628:therapy; D001683:Biological Clocks; D002909:Chronobiology Phenomena; D002940:Circadian Rhythm; D005260:Female; D006761:Hospitals; D006801:Humans; D008297:Male; D008875:Middle Aged; D012621:Seasons; D013997:Time Factors; D016896:Treatment Outcome