title: Adherence and nonadherence to antipsychotic medications.
abstract: The aims of this study were to identify dimensions of reasons for adherence and nonadherence to antipsychotic medications, and their associations with clinical and demographic profiles. A total number of 106 participants with DSM-IV psychosis spectrum disorders from two larger studies in inpatient and community settings participated. The Rating of Medication Influences (ROMI) Scale was used to measure subjective reasons for adherence and nonadherence. A series of multiple regression analyses found that mood symptom scores on the Positive and Negative Syndrome Scale (PANSS) predicted most dimensions of reasons for adherence and nonadherence. Higher mood scores were associated with positive affinity for medications and positive relationship with clinicians. Lower mood scores predicted four out of five reasons for nonadherence. Adherence and nonadherence behaviors were determined by different variables and were not mirror opposites.
authors: Department of Psychosocial & Community Health, University of Washington, School of Nursing, Seattle, Washington 98195-7263, USA. ykozuki@u.washington.edu
authors: Yoriko
authors: Y
authors: Kozuki
authors: Karen G
authors: KG
authors: Schepp
mesh_terms: D000328:Adult; D000339:Affect; D000368:Aged; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D016000:Cluster Analysis; D003717:Denial, Psychological; D005163:Factor Analysis, Statistical; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D008875:Middle Aged; D009042:Motivation; D015999:Multivariate Analysis; D015404:Nursing Methodology Research; D010349:Patient Compliance / Q000523:psychology*; D011237:Predictive Value of Tests; D011594:Psychometrics; D011618:Psychotic Disorders / Q000188:drug therapy / Q000523:psychology; D012044:Regression Analysis; D012307:Risk Factors; D012565:Schizophrenic Psychology; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires / Q000592:standards*; D016312:Treatment Refusal / Q000523:psychology*
chemical_list: D014150:Antipsychotic Agents