Structural emphysema does not correlate with lung compliance: lessons from the mouse smoking model.
The murine smoke-induced model produces histologic emphysema. The authors sought to assess whether the structural emphysema that occurred correlated with the development of compliance changes. The study exposed 2 strains of mice (CBA/J/J x C57BL/6J and A/J) to chronic cigarette smoke. Lung compliance and morphometry were measured. The smoking model generated significant emphysema in A/J mice in the absence of changes in compliance, lung matrix, or apoptosis. Importantly, there was no correlation between the emphysema measured by lung morphometry and pulmonary compliance. This lack of correlation suggests that the mechanisms involved in anatomic emphysema may be distinct from those that cause the loss of elastic recoil.
Foronjy
Robert F
RF
Department of Medicine, Division of Molecular Medicine and Pulmonary Medicine, Columbia University, New York, USA.
Mercer
Becky A
BA
Maxfield
Mark W
MW
Powell
Charles A
CA
D'Armiento
Jeanine
J
Okada
Yasunori
Y
D000818:Animals; D017209:Apoptosis; D001835:Body Weight; D001992:Bronchoalveolar Lavage Fluid; D053148:Caspase 3; D020169:Caspases / Q000378:metabolism; D024042:Collagen Type I / Q000378:metabolism; D024061:Collagen Type III / Q000378:metabolism; D004195:Disease Models, Animal; D004549:Elastin / Q000378:metabolism; D004646:Emphysema / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D006909:Hydroxyproline / Q000378:metabolism; D020287:In Situ Nick-End Labeling; D008168:Lung / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008170:Lung Compliance; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010447:Peptide Hydrolases / Q000378:metabolism; D011014:Pneumonia / Q000473:pathology / Q000503:physiopathology; D012907:Smoking / Q000009:adverse effects*
D024042:Collagen Type I; D024061:Collagen Type III; D004549:Elastin; D010447:Peptide Hydrolases; C505409:Casp3 protein, mouse; D053148:Caspase 3; D020169:Caspases; D006909:Hydroxyproline