title: Treating depression in a mother of five: what to do when the first step fails.
abstract: What should one do with a depressed patient who does not get better? If depression does not respond to an antidepressant given in adequate doses for an adequate time, logical next steps include increasing the dose, adding a different medication, or adding a nonpharmacologic therapy. Or one can reconsider the diagnosis.
authors: Department of Psychiatry and Psychology, The Cleveland Clinic Foundation, OH 44195, USA. tesarg@ccf.org
authors: George E
authors: GE
authors: Tesar
mesh_terms: D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage; D001714:Bipolar Disorder / Q000175:diagnosis; D016642:Bupropion / Q000008:administration & dosage; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000188:drug therapy*; D003937:Diagnosis, Differential; D039721:Diagnostic and Statistical Manual of Mental Disorders; D018450:Disease Progression; D005260:Female; D006801:Humans; D009035:Mothers / Q000523:psychology*; D011320:Primary Health Care / Q000379:methods*; D012008:Recurrence; D012307:Risk Factors; D017211:Treatment Failure
chemical_list: D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion