Non-invasive quantification of lactate by proton MR spectroscopy and its clinical applications.
Lactate is an important metabolite in clinical cases indicating the status of metabolic impairment. We applied a clinically relevant simple method for lactate quantification using magnetic resonance spectroscopy (MRS). We used two long in-phase echo time (TE=272,544 ms) to calculate T2 relaxation time and the absolute concentration of lactate. This method was optimized using phantom study and applied to clinical cases. This technique does not require complicated processing and could be applied in daily clinical practice. Moreover, this technique enables lactate quantification in cases (e.g. tumor) where lipid peak is overlapped with the lactate peak at short echo times.
Matsumura
Akira
A
Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba Science City, Ibaraki, 305-8575, Japan. matsumur@md.tsukuba.ac.jp
Isobe
Tomonori
T
Takano
Shingo
S
Kawamura
Hiraku
H
Anno
Izumi
I
D000328:Adult; D000368:Aged; D001834:Body Water / Q000378:metabolism; D020520:Brain Infarction / Q000378:metabolism*; D001932:Brain Neoplasms / Q000378:metabolism*; D005260:Female; D005910:Glioma / Q000378:metabolism*; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism*; D008223:Lymphoma / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged
D019344:Lactic Acid