Congenic/consomic models of hypertension.
Human essential hypertension is a complex, multifactorial, quantitative trait under polygenic control. Despite major recent advances in genome sequencing and statistical tools, the genetic dissection of essential hypertension still provides a formidable challenge. Genetic models of essential hypertension such as the spontaneously hypertensive stroke-prone rat (SHRSP) provide the scientist with genetic homogeneity, not possible within a human population, to aid the search for causative genes. The principal strategy in the rat has been the identification of quantitative trait loci (QTL) responsible for blood-pressure regulation by genome-wide scanning. In this chapter we focus on congenic and consomic breeding strategies for the confirmation of QTL and the genetic dissection of the implicated regions.
Graham
Delyth
D
BHF Glasgow Cardiovascular Research Centre, University of Glasgow, UK.
McBride
Martin W
MW
Brain
Nicholas J R
NJ
Dominiczak
Anna F
AF
D000818:Animals; D001794:Blood Pressure / Q000235:genetics; D004195:Disease Models, Animal; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology*; D016133:Polymerase Chain Reaction; D040641:Quantitative Trait Loci; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY