title: Candidemia in pediatric outpatients receiving home total parenteral nutrition.
abstract: This is a cohort study of pediatric outpatients receiving total parenteral nutrition (TPN) and follow-up care in a Tennessee hospital between January and June 1999. The study was conducted following an increase in the incidence of candidemia. Of 13 children receiving home TPN, five had candidemia; three were due to Candida parapsilosis. Case patients were more likely to have an underlying hematologic disease (P = 0.02) as well as previous history of fungemia (P = 0.02). Two case patients had successive candidemia episodes 3 months apart; karyotypes and RAPD profiles of each patient's successive C. parapsilosis isolates were similar. Candida spp. were frequently detected in hand cultures from cohort members (four of 10) and family member caregivers (nine of 11); C parapsilosis was isolated from five caregivers. Our findings underscore the challenges of maintaining stringent infection control practices in the home health care setting and suggest the need for more intensive follow-up and coordination of home TPN therapy among pediatric patients.
authors: Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. mcano@cdc.gov
authors: M V
authors: MV
authors: Cano
authors: J F
authors: JF
authors: Perz
authors: A S
authors: AS
authors: Craig
authors: M
authors: M
authors: Liu
authors: G M
authors: GM
authors: Lyon
authors: M E
authors: ME
authors: Brandt
authors: T J
authors: TJ
authors: Lott
authors: B A
authors: BA
authors: Lasker
authors: F F
authors: FF
authors: Barrett
authors: M M
authors: MM
authors: McNeil
authors: W
authors: W
authors: Schaffner
authors: R A
authors: RA
authors: Hajjeh
mesh_terms: D000293:Adolescent; D000553:Ambulatory Care; D002175:Candida / Q000302:isolation & purification; D002177:Candidiasis / Q000453:epidemiology / Q000209:etiology*; D017028:Caregivers; D002648:Child; D015331:Cohort Studies; D003428:Cross Infection / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D016469:Fungemia / Q000453:epidemiology / Q000209:etiology*; D006225:Hand / Q000382:microbiology; D006776:Hospitals, Pediatric; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D012307:Risk Factors; D013045:Species Specificity; D013714:Tennessee / Q000453:epidemiology