[Clinical observation of propofol combined with misoprostol for painless induced abortion].
OBJECTIVE
To observe the effects of propofol combined with misoprostol for painless induced abortion.


METHODS
Two hundred early pregnant women, nullipara or pluripara with history of cesarean section, were randomly divided into two groups: control group receiving intravenous injection of propofol 2.5 mg/kg and then underwent induced abortion after becoming unconscious, and experimental group receiving misoprostol 200 microg intravaginally two hours before undergoing induced abortion. The effects on anesthesia, cervix dilatation, uterotonic degree, bleeding and abortion syndrome were observed.


RESULTS
Anesthesia was 100% effective in both groups. No induced abortion syndrome occurred. For the effect on cervical dilatation, No.6 Hegars dilator were smoothly inserted into the cervical canal in 96 cases (96%) in the experimental group and in only 8 cases (8%) in the control group (P < 0.01). For the effect on uterotonic degree, 79 cases in the experimental group (79%) and 30 cases in the control group (30%) showed 1 approximately 2 cm of uterine contraction (P < 0.01). Seventy-five cases in the experimental group (75%) and 25 cases in the control group (25%) showed blood loss of less than 15 ml (P < 0.01).


CONCLUSIONS
Intravenous injection of propofol combined with misoprostol administered intravaginally is effective in anesthesia and cervical dilatation with less bleeding and absence of abortion syndrome.
Fan
Guang-sheng
GS
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peding Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Jin
Li
L
Xi
Shui
S
Li
Hong
H
D000028:Abortion, Induced / Q000379:methods*; D000328:Adult; D018686:Anesthetics, Intravenous; D004107:Dilatation and Curettage; D005260:Female; D006801:Humans; D016595:Misoprostol / Q000008:administration & dosage*; D011247:Pregnancy; D015742:Propofol / Q000008:administration & dosage*
D018686:Anesthetics, Intravenous; D016595:Misoprostol; D015742:Propofol