title: Physical complaints in ageing persons with spinal muscular atrophy.
abstract: OBJECTIVE
  While life expectancy is improving for persons with spinal muscular atrophy, new physical complaints may arise. To investigate this, we studied persons with a long duration and severe course (high functional limitations) of the disease.
  
  
  METHODS
  Cross-sectional descriptive study.
  
  
  METHODS
  Persons with spinal muscular atrophy.
  
  
  METHODS
  Questionnaires and structured interviews on prevalence of physical complaints and their duration. Of 190 questionnaires 99 were returned; of 23 persons (with the longest disease duration and high functional limitation level) selected for structured medical interviews 9 participated.
  
  
  RESULTS
  Patterns common within and different between the different types of spinal muscular atrophy were identified. Of the 10 most common complaints, types 1-2 had a significantly higher prevalence of kyphoscoliosis, difficulty in coughing, joint contractures and voice/speech problems, while type 3 had a significantly higher prevalence of fatigue. No statistically significant correlation was found between the appearance of physical complaints and disease duration. However, sleeping and swallowing problems were in the 5 most common complaints with the shortest mean time of appearance. The structured interview revealed hypermobility in the hand, suffusion of the eyes, and itching as new complaints with high prevalence.
  
  
  CONCLUSIONS
  There are indications that the frequency of less well-known physical complaints increases with ageing.
authors: iRv, Institute for Rehabilitation Research, Hoensbroek, The Netherlands. i.degroot@irv.nl
authors: Imelda J M
authors: IJ
authors: de Groot
authors: Luc P
authors: LP
authors: de Witte
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D002648:Child; D015331:Cohort Studies; D015897:Comorbidity; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D008017:Life Expectancy; D008297:Male; D009134:Muscular Atrophy, Spinal / Q000150:complications / Q000503:physiopathology*; D014897:Spinal Muscular Atrophies of Childhood / Q000150:complications / Q000503:physiopathology*; D011795:Surveys and Questionnaires