title: QRST isointegral departure mapping after exercise in patients with congenital long QT syndrome.
abstract: Congenital long QT syndrome (LQTS) is known to be a critical syndrome associated with a bizarre T wave, prolonged QT interval, and ventricular arrhythmias and is followed by syncope and/or sudden death. Body surface mapping, especially QRST isointegral departure mapping, was used after exercise to assess exercise-induced repolarization changes in patients with this syndrome. This study included 12 patients with the Romano-Ward syndrome (LQTS group, 9 women, 30 +/- 19 years) and 19 healthy adults (control group, 5 women, 24 +/- 5 years). In the LQTS group, there was a significant increase in the number of local extrema and abnormal points after exercise in the departure maps. In the LQTS group, QRST isointegral departure mapping presented more marked abnormalities of repolarization after an exercise stress test. In mild cases that revealed abnormalities only after the exercise stress, such testing may be helpful for LQTS diagnosis.
authors: Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan.
authors: Kimio
authors: K
authors: Tsukahara
authors: Tetsuya
authors: T
authors: Hirata
authors: Masanobu
authors: M
authors: Hirata
authors: Motonobu
authors: M
authors: Hayano
authors: Katsusuke
authors: K
authors: Yano
mesh_terms: D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D018780:Body Surface Potential Mapping / Q000379:methods*; D016022:Case-Control Studies; D002648:Child; D004562:Electrocardiography / Q000379:methods; D005080:Exercise Test; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D008133:Long QT Syndrome / Q000151:congenital* / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion / Q000502:physiology*
chemical_list: D000319:Adrenergic beta-Antagonists