title: Serum carotenoid concentrations are inversely associated with serum aminotransferases in hyperglycemic subjects.
abstract: Hyperglycemia increases the generation of free radicals by glucose auto-oxidation, and the increment of free radicals may lead to liver cell damage. In this study, we tested the hypothesis that hyperglycemia-induced increases of serum liver enzymes among its physiological concentration would be inversely associated with serum antioxidant carotenoid level. Study subjects were 857 male and female Japanese who had received health examinations in 2003. Those with a history of liver disease and excessive alcohol drinkers were excluded. The associations of serum six-carotenoid concentrations with serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) stratified by glucose tolerance status were evaluated cross-sectionally. Serum AST and ALT concentrations in the groups of impaired fasting glucose (IFG) and diabetes were significantly higher than those in the normal group. The multivariate-adjusted means of the serum AST and ALT concentrations in IFG and diabetes group were significantly low in accordance with the tertiles of the serum beta-cryptoxanthin and beta-carotene concentrations. The most inverse association of serum liver enzyme and carotenoid concentration was observed in beta-cryptoxanthin. Antioxidant carotenoid, especially beta-cryptoxanthin, may act a deterrent substance against increasing the serum aminotransferase in the earlier pathogenesis of liver dysfunction among hyperglycemic subjects.
authors: Department of Citrus Research, National Institute of Fruit Tree Science, 485-6 Shimizu-Okitsu-nakachou, Shizuoka-shi, Shizuoka 424-0292, Japan. msugiura@affrc.go.jp
authors: Minoru
authors: M
authors: Sugiura
authors: Mieko
authors: M
authors: Nakamura
authors: Yoshinori
authors: Y
authors: Ikoma
authors: Masamichi
authors: M
authors: Yano
authors: Kazunori
authors: K
authors: Ogawa
authors: Hikaru
authors: H
authors: Matsumoto
authors: Masaya
authors: M
authors: Kato
authors: Makoto
authors: M
authors: Ohshima
authors: Akihiko
authors: A
authors: Nagao
mesh_terms: D000410:Alanine Transaminase / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood*; D003430:Cross-Sectional Studies; D065366:Cryptoxanthins; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006943:Hyperglycemia / Q000097:blood*; D007564:Japan; D008099:Liver / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D024341:Xanthophylls; D019207:beta Carotene / Q000031:analogs & derivatives / Q000097:blood*
chemical_list: D065366:Cryptoxanthins; D024341:Xanthophylls; D019207:beta Carotene; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase