In vitro enzyme inhibition activities of crude ethanolic extracts derived from medicinal plants of Pakistan.
Twenty two crude ethanolic extracts from 14 indigenous medicinal plants were subjected to enzyme inhibition screening against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and lipoxygenase enzymes (LO). Three extracts showed activity against AChE, nine extracts were found to be active against BChE and four extracts inhibited the enzyme LO. The most significant inhibition activities (> or =50%) were found in extracts derived from Aloe vera (leaves), Alpinia galanga (rhizome), Curcuma longa (rhizome), Cymbopogon citratus (leaves), Ocimum americanum (leaves), Ocimum americanum (stem) and Withania somnifera (roots).
Khattak
Somia
S
Department of Chemistry, University of Peshawar, Peshawar - 25120, Pakistan. somiakhattak@yahoo.com
Saeed-Ur-Rehman
Shah
Hameed Ullah
HU
Khan
Taous
T
Ahmad
Manzoor
M
D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D000431:Ethanol / Q000737:chemistry; D006801:Humans; D066298:In Vitro Techniques; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology; D010154:Pakistan; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry
D002800:Cholinesterase Inhibitors; D004791:Enzyme Inhibitors; D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts; D012997:Solvents; D000431:Ethanol