Repeated regression of pulmonary metastases from renal cell carcinoma after treatment using different interferon-alpha preparations.
A 49-year-old man with pulmonary metastasis from renal cell carcinoma (RCC) was treated with recombinant IFN-alpha2b (Intron A). A complete response was achieved within 4 months and thereafter persisted for 5 years until he developed another lung lesion. Interleukin-2 (Imunace) was administered without any response. Finally, he was treated by natural IFN-alpha (OIF). The pulmonary lesion achieved a partial response after 11 months of treatment. Because IFN-alpha preparations include different subtypes, changing the use of IFN-alpha preparations may thus be a potentially useful option for the successful immunotherapy of RCC.
Oya
Mototsugu
M
Department of Urology, Keio University School of Medicine, Tokyo, Japan. moto-oya@sc.itc.keio.ac.jp
Asakura
Hirotaka
H
Mizuno
Ryuichi
R
Marumo
Ken
K
Murai
Masaru
M
D000970:Antineoplastic Agents / Q000494:pharmacology*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy*; D006801:Humans; D007167:Immunotherapy; D016898:Interferon-alpha / Q000494:pharmacology*; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
D000970:Antineoplastic Agents; D016898:Interferon-alpha