title: Novel one-pot total syntheses of deoxyvasicinone, mackinazolinone, isaindigotone, and their derivatives promoted by microwave irradiation.
abstract: [reaction: see text]. Total syntheses of deoxyvasicinone (1), mackinazolinone (2), and 8-hydroxydeoxyvasicinone (3) via novel microwave-assisted domino reactions, as well as a novel three-component one-pot total synthesis of isaindigotone (5) promoted by microwave irradiation, are reported. The efficient reaction process enabled us to rapidly access related natural product derivatives and to identify a new class of cytotoxic agents.
authors: ArQule, Inc., Woburn, Massachusetts 10801, USA.
authors: Ji-Feng
authors: JF
authors: Liu
authors: Ping
authors: P
authors: Ye
authors: Kevin
authors: K
authors: Sprague
authors: Katie
authors: K
authors: Sargent
authors: Daniel
authors: D
authors: Yohannes
authors: Carmen M
authors: CM
authors: Baldino
authors: Christopher J
authors: CJ
authors: Wilson
authors: Shi-Chung
authors: SC
authors: Ng
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry; D052999:Quinazolinones; D011827:Radiation
chemical_list: D000470:Alkaloids; D011799:Quinazolines; D052999:Quinazolinones; C440668:isaindigotone; C510340:mackinazolinone; C025696:2,3-trimethylene-4-quinazolone