title: Effects of combined cataract surgery and trabeculectomy with mitomycin C on ocular dimensions.
abstract: OBJECTIVE
  To characterise changes in ocular dimensions after combined cataract operation and trabeculectomy with mitomycin C using separate incisions (combined operation).
  
  
  METHODS
  24 consecutive eyes that had combined operation and 16 eyes that had cataract operation alone were enrolled. The axial lengths before and after operations were determined with non-contact optical coherence biometry. The intraocular pressures (IOP), axial lengths, corneal curvatures, and the expected and observed refractive errors before and after operations were compared.
  
  
  RESULTS
  After a combined operation, mean IOP was significantly reduced from 16.6 (SD 5.8) mm Hg to 10.9 (4.1) mm Hg (p<0.00001), and mean axial length was significantly shortened from 24.10 (0.98) mm to 23.98 (0.96) mm (p<0.00001). The mean axial length reduction after combined operation (117 (57) microm) was significantly larger than the reduction after cataract operation alone (75 (38) microm, p<0.02), and correlated significantly with the postoperative IOP (p<0.002). There was a mean with the rule surgically induced corneal astigmatism of 0.44 (0.83) dioptre by vector analysis, and a significant increase of mean keratometry reading of 0.23 (0.46) dioptre after a combined operation. However, there was no significant difference between the expected and observed refractive errors.
  
  
  CONCLUSIONS
  Despite an alteration of the axial length and corneal curvature, the refractive outcome after a combined operation did not differ significantly from the predicted refraction.
authors: MD, 100 Stein Plaza #2-235, Jules Stein Eye Institute, Los Angeles, CA 90095, USA. law@jsei.ucla.edu
authors: S K
authors: SK
authors: Law
authors: A M
authors: AM
authors: Mansury
authors: D
authors: D
authors: Vasudev
authors: J
authors: J
authors: Caprioli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001699:Biometry; D002386:Cataract / Q000150:complications*; D003315:Cornea / Q000473:pathology; D005123:Eye / Q000473:pathology*; D005260:Female; D005901:Glaucoma / Q000150:complications* / Q000601:surgery; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D016685:Mitomycin / Q000627:therapeutic use; D019384:Nucleic Acid Synthesis Inhibitors / Q000627:therapeutic use; D018918:Phacoemulsification; D011184:Postoperative Period; D012030:Refractive Errors / Q000209:etiology; D014130:Trabeculectomy
chemical_list: D019384:Nucleic Acid Synthesis Inhibitors; D016685:Mitomycin