Leishmania donovani: effect of therapy on expression of CD2 antigen and secretion of macrophage migration inhibition factor by T-cells in patients with visceral leishmaniasis.
Visceral leishmaniasis (VL) commonly known as Kala-azar in India is one of the several clinically important infections, where Th1 sub-population of CD4+ T-cells, despite a pre-requisite, fails to express macrophage migration inhibition factor (MIF) and interferon-gamma which both activate the macrophage and coordinate the immune response to intra-cellular Leishmania sp. Expression of CD2 receptors before and after antileishmanial therapy on CD4+ T-cells of VL patients and their corresponding effect on MIF were examined. Before treatment the number of T-cells expressing CD2 was low which incorporated insignificant MIF response. The immunological reconstitution was, however, observed after treatment as manifested through upregulation of CD2+ T-cells with pronounced MIF generation response. The study, therefore, identifies a possible role of CD2 antigen in immunity to VL.
Bimal
S
S
Division of Immunology, Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, India. drsbimal@yahoo.com
Singh
S K
SK
Das
V N R
VN
Sinha
P K
PK
Gupta
A K
AK
Bhattacharya
S K
SK
Das
P
P
D000818:Animals; D000967:Antimony Sodium Gluconate / Q000494:pharmacology / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000494:pharmacology / Q000627:therapeutic use; D018801:CD2 Antigens / Q000096:biosynthesis* / Q000187:drug effects; D016022:Case-Control Studies; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007893:Leishmania donovani / Q000187:drug effects / Q000276:immunology*; D007898:Leishmaniasis, Visceral / Q000188:drug therapy* / Q000276:immunology; D008263:Macrophage Migration-Inhibitory Factors / Q000378:metabolism*; D008297:Male; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D000981:Antiprotozoal Agents; D018801:CD2 Antigens; D008263:Macrophage Migration-Inhibitory Factors; D000967:Antimony Sodium Gluconate