[Correlation of tissue factor expression to angiogenesis of gastric carcinoma and its clinical significance].
OBJECTIVE
Tissue factor (TF), the primary physiologic initiator of coagulation cascade, is involved in the process of angiogenesis of various malignancies. This study was designed to investigate the correlation of TF expression to angiogenesis of gastric carcinoma, and to study its clinical significance.


METHODS
The expression of TF and vascular endothelial growth factor (VEGF) in 80 specimens of gastric carcinoma and 20 specimens of normal gastric tissue was detected by EnVision immunohistochemistry. Tumor microvessel density (MVD) was evaluated using anti-CD34 antibody as an endothelial marker with the same technique as well.


RESULTS
Positive rates of TF and VEGF, and the mean value of MVD were significantly higher in gastric carcinoma than in normal gastric tissue (65.00% vs. 5.00%, P<0.01; 67.50% vs. 5.00%, P<0.05; and 36.14+/-9.94 vs. 12.10+/-3.27, P<0.05). TF expression was positively correlated with VEGF expression and MVD value (P<0.05). TF expression was correlated to the overall survival times of patients, TNM stage, and liver metastasis (P<0.05).


CONCLUSIONS
Overexpression of TF relates with angiogenesis and prognosis of gastric carcinoma.
Jiao
Zuo-Yi
ZY
Department of Oncology Surgery, The First Hospital, Lanzhou University, Lanzhou, Gansu, 730000, PR China. jiaozuoyi@163.com
Gou
Chang-Zheng
CZ
Cao
Nong
N
Li
Yu-Min
YM
D000230:Adenocarcinoma / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D008833:Microcirculation / Q000473:pathology; D008875:Middle Aged; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic; D011379:Prognosis; D013274:Stomach Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D015996:Survival Rate; D013925:Thromboplastin / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D018952:Antigens, CD34; D042461:Vascular Endothelial Growth Factor A; D013925:Thromboplastin