[Expression of KAI1/CD82 in neuroblastoma and its correlation to prognosis].
OBJECTIVE
KAI1/CD82 was recently detected as a tumor metastasis suppressor gene. Its silencing contributes to progression and infiltration of some tumors. Our study was designed to investigate the expression of KAI1/CD82 in neuroblastoma, and explore its correlation to clinicopathologic characteristics and prognosis of patients with neuroblastoma.


METHODS
The EnVision immunohistochemistry was used to detect the expression of KAI1/CD82 in 90 specimens of neuroblastoma (28 specimens of ganglioneuroblastoma and 62 specimens of neuroblastoma). Clinical data and follow-up data of the 90 patients were analyzed.


RESULTS
Positive rate of KAI1/CD82 was significantly higher in ganglioneuroblastoma than in neuroblastoma (39.3% vs. 14.5%, P=0.014). Its expression was negatively correlated to clinical stage of neuroblastoma (P=0.003).


CONCLUSIONS
The change of KAI1/CD82 expression is an early event in tumorigenesis of neuroblastoma. Its down-regulation may be considered as a potential indicator to judge the differentiation and metastasis of neuroblastoma, which can serve as one of the combined indexes to clinical assessment of prognosis.
Wu
Xiang-Ru
XR
Department of Pathology, Changhai Hospital, The Second Military Medical University, Shanghai, 200433, PR China.
Zhu
Ming-Hua
MH
Zhang
Zhong-De
ZD
D000310:Adrenal Gland Neoplasms / Q000378:metabolism* / Q000473:pathology; D014408:Biomarkers, Tumor; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D018305:Ganglioneuroblastoma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007223:Infant; D051861:Kangai-1 Protein / Q000378:metabolism*; D008207:Lymphatic Metastasis; D042601:Lymphatic Vessels / Q000378:metabolism; D008297:Male; D008479:Mediastinal Neoplasms / Q000378:metabolism / Q000473:pathology; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000378:metabolism* / Q000473:pathology; D010534:Peritoneal Neoplasms / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D015996:Survival Rate
D014408:Biomarkers, Tumor; D051861:Kangai-1 Protein