Living donor liver transplantation for hepatitis C related hepatocellular carcinoma in a haemophilia A patient.
We report the first case of unrelated living liver transplantation for hepatitis C related hepatocellular carcinoma (HCC) in a Chinese patient with haemophilia A. The development of cirrhosis and HCC was insidious in this patient, who has previously failed interferon treatment despite low viral load and genotype 6a. With factor VIII and novoseven support, there were no operative complications and there was no need for blood transfusion. Postoperative pegulated interferon treatment resulted in viral clearance with no increased cellular rejection. The use of living donors represent a potential life saving therapeutic options for hepatitis C virus related complications in haemophiliac, especially in countries of organ shortage. Careful patient and donor choice, meticulous surgical expertise and proper counselling, however, are prudent requirements.
Au
W Y
WY
Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China. auwing@hotmail.com
Liu
C L
CL
Lo
C M
CM
Fan
S T
ST
Lam
C K
CK
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000601:surgery*; D006467:Hemophilia A / Q000150:complications*; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D016896:Treatment Outcome