Selective detection of catecholamines by synthetic receptors embedded in chromatic polydiacetylene vesicles.
A new detection scheme for catecholamines was constructed through embedding synthetic receptors within vesicles comprising phospholipids and polydiacetylene. Fluorescence emission of the polydiacetylene was induced through specific interactions between the soluble ligands and the vesicle-incorporated hosts. The system demonstrated remarkable selectivity among structurally similar ligands and achieved much lower detection thresholds compared to that of other reported catecholamine sensors. The chromatic assembly provides a generic route for high sensitivity detection of ligand-receptor interactions.
Kolusheva
Sofiya
S
Ilse Katz Center for Nanotechnology and Department of Chemistry, Ben Gurion University, Beer Sheva, Israel 84105.
Molt
Oliver
O
Herm
Michael
M
Schrader
Thomas
T
Jelinek
Raz
R
D000114:Acetylene / Q000031:analogs & derivatives* / Q000737:chemistry; D002395:Catecholamines / Q000032:analysis* / Q000737:chemistry; D003124:Colorimetry; D005453:Fluorescence; D008823:Micelles; D000078789:Polyacetylene Polymer; D011108:Polymers / Q000737:chemistry*; D053279:Polyynes; D017983:Receptors, Catecholamine / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry*
D002395:Catecholamines; D008823:Micelles; D000078789:Polyacetylene Polymer; D011108:Polymers; D017983:Receptors, Catecholamine; D013501:Surface-Active Agents; D053279:Polyynes; C082361:polydiacetylene; D000114:Acetylene