Recent applications of protein crystallography and structure-guided drug design.
Technological advances to increase the throughput of purified protein production and co-crystallization of target proteins with small molecules have helped to solidify the role that structure via crystallography has on drug discovery. Visualization of how drug-like molecules bind to the target protein is a key step in driving follow-up or preclinical chemistry to improve characteristics of the molecule. Using structural information to guide small-molecule design and generate new chemical ideas is now a mainstay in the drug discovery process.
Williams
Shawn P
SP
Department of Computational, Analytical and Structural Sciences, GlaxoSmithKline Discovery Research, Research Triangle Park, NC 27709, USA.
Kuyper
Lee F
LF
Pearce
Kenneth H
KH
D018360:Crystallography, X-Ray; D015195:Drug Design; D006801:Humans; D011485:Protein Binding; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D013329:Structure-Activity Relationship
D011506:Proteins