title: [Summarization in the research of canstatin].
abstract: Canstatin protein, a newly found angiogenesis inhibitor, has powerful anti-angiogenesis effect. Canstatin is the N terminal fragment of collagen IV alpha2 chain NC1 domain. Its distinct anti-cancer effect in mouse model and low toxicity has not only made it a promising new anti-cancer drug candidate, but also drawn much attention of researchers. The detection, denomination, biological characters and mechanism of canstatin protein, and also the prospect of its application were summarized.
authors: Institute of Respiratory Disease, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China. lzhlyyhy@163.com
authors: Yuying
authors: Y
authors: Li
authors: Guisheng
authors: G
authors: Qian
authors: Guijun
authors: G
authors: Huang
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D024141:Collagen Type IV / Q000494:pharmacology*; D006801:Humans; D051379:Mice
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D024141:Collagen Type IV