Influence of thyroid hormone treatment on the respiratory activity of cerebral mitochondria from hypothyroid rats. A critical re-assessment.
Effects of treatment with thyroid hormones L-3,5,3'-tri-iodothyronine (T3) and L-thyroxine (T4) on oxidative energy metabolism in cerebral mitochondria from hypothyroid adult rats were examined. It was observed that T3 and T4 stimulated respiratory activity in a substrate-specific and dose-dependent manner. The results also suggest that the synthesis of cytochrome aa3 and of cytochrome c may be dependent on both T3 as well as T4 whereas higher concentrations than normal of T3 and T4 may have a catabolic influence on cytochrome b content.
Katyare
Surendra S
SS
Department of Biochemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat 390 002, India. sskatyare_msu2001@yahoo.com
Rajan
Rema R
RR
D000818:Animals; D000831:Animals, Newborn; D002540:Cerebral Cortex / Q000166:cytology*; D003580:Cytochromes / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D007037:Hypothyroidism / Q000097:blood / Q000188:drug therapy*; D008293:Malates / Q000378:metabolism; D008928:Mitochondria / Q000187:drug effects* / Q000502:physiology; D010766:Phosphorylation / Q000187:drug effects; D019289:Pyruvic Acid / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012119:Respiration / Q000187:drug effects*; D019802:Succinic Acid / Q000378:metabolism; D013963:Thyroid Hormones / Q000097:blood / Q000627:therapeutic use*; D013965:Thyroidectomy / Q000379:methods
D003580:Cytochromes; D008293:Malates; D013963:Thyroid Hormones; C030298:malic acid; D019289:Pyruvic Acid; D019802:Succinic Acid