title: Local release of C-reactive protein from vulnerable plaque or coronary arterial wall injured by stenting.
abstract: OBJECTIVE
  The purpose of this study was to assess local release of C-reactive protein (CRP) from atherosclerotic plaques or the vessel wall injured by stenting.
  
  
  BACKGROUND
  Recent research has focused on the local production of CRP, especially in inflammatory atherosclerotic plaques.
  
  
  METHODS
  The study consisted of two separate protocols. In protocol 1, we measured serum high-sensitivity-CRP (hs-CRP) levels in coronary arterial blood sampled just distal and proximal to the culprit lesions in 36 patients with stable angina and 13 patients with unstable angina. In protocol 2, we measured serial serum hs-CRP levels and activated Mac-1 on the surface of neutrophils in both coronary sinus and peripheral blood in 20 patients undergoing coronary stenting.
  
  
  RESULTS
  In protocol 1, CRP was higher in distal blood than proximal blood in both stable (p < 0.05) and unstable angina (p < 0.01). The translesional CRP gradient (distal CRP minus proximal CRP, p < 0.05) as well as the proximal CRP (p < 0.05) and distal CRP (p < 0.05) was higher in unstable angina than in stable angina. In protocol 2, the transcardiac CRP gradient (coronary sinus minus peripheral blood) and activated Mac-1 increased gradually after stenting, reaching a maximum at 48 h (p < 0.001 vs. baseline for both). There was a positive correlation between the transcardiac CRP gradient and activated Mac-1 at 48 h (r = 0.45, p < 0.01).
  
  
  CONCLUSIONS
  C-reactive protein is an excellent marker for plaque instability or poststent inflammatory status, and its source might be the inflammation site of the plaque or the coronary arterial wall injured by stenting.
authors: Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine, Saga, Japan. inouete@med.saga-u.ac.jp
authors: Teruo
authors: T
authors: Inoue
authors: Toru
authors: T
authors: Kato
authors: Toshihiko
authors: T
authors: Uchida
authors: Masashi
authors: M
authors: Sakuma
authors: Atsuko
authors: A
authors: Nakajima
authors: Mitsuei
authors: M
authors: Shibazaki
authors: Yoshitaka
authors: Y
authors: Imoto
authors: Masahiko
authors: M
authors: Saito
authors: Shigemasa
authors: S
authors: Hashimoto
authors: Yutaka
authors: Y
authors: Hikichi
authors: Koichi
authors: K
authors: Node
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000097:blood / Q000378:metabolism*; D000789:Angina, Unstable / Q000097:blood / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism*; D002985:Clinical Protocols; D003324:Coronary Artery Disease / Q000097:blood / Q000378:metabolism*; D023903:Coronary Restenosis / Q000209:etiology; D003331:Coronary Vessels / Q000293:injuries* / Q000378:metabolism; D005260:Female; D006801:Humans; D016177:Macrophage-1 Antigen / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism; D012044:Regression Analysis; D015607:Stents
chemical_list: D016177:Macrophage-1 Antigen; D002097:C-Reactive Protein