title: Cyclic urea derivatives as potent NK1 selective antagonists.
abstract: A series of novel five- and six-membered ring urea derivatives have been described as potent and selective NK1 receptor antagonists. Several compounds in this series exhibited good oral activity and brain penetration. Syntheses of these compounds are also described herein.
authors: Chemical Research Department, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
authors: Ho-Jane
authors: HJ
authors: Shue
authors: Xiao
authors: X
authors: Chen
authors: Neng-Yang
authors: NY
authors: Shih
authors: David J
authors: DJ
authors: Blythin
authors: Sunil
authors: S
authors: Paliwal
authors: Ling
authors: L
authors: Lin
authors: Danlin
authors: D
authors: Gu
authors: John H
authors: JH
authors: Schwerdt
authors: Sapna
authors: S
authors: Shah
authors: Gregory A
authors: GA
authors: Reichard
authors: John J
authors: JJ
authors: Piwinski
authors: Ruth A
authors: RA
authors: Duffy
authors: Jean E
authors: JE
authors: Lachowicz
authors: Vicki L
authors: VL
authors: Coffin
authors: Fei
authors: F
authors: Liu
authors: Amin A
authors: AA
authors: Nomeir
authors: Cynthia A
authors: CA
authors: Morgan
authors: Geoffrey B
authors: GB
authors: Varty
mesh_terms: D000818:Animals; D001682:Biological Availability; D004305:Dose-Response Relationship, Drug; D005849:Gerbillinae; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D064729:Neurokinin-1 Receptor Antagonists; D011485:Protein Binding; D051381:Rats; D013329:Structure-Activity Relationship; D014508:Urea / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D006571:Heterocyclic Compounds; D064729:Neurokinin-1 Receptor Antagonists; D014508:Urea