Effect of experimental desynchronosis on immunotoxicity of benz(a)pyrene in (CBAxC57Bl)F1 mice.
Experiments on (CBA x C57Bl)F1 mice showed that constant (day and night) illumination for 2 weeks led to the development of internal desynchronosis, which significantly modulated the reaction of the immune system to benz(a)pyrene compared to those in intact animals. Presumably, the differences were associated with changed circadian rhythms of the immune parameters in experimental animals determining different ratios and, presumably, functions of immunocompetent cells during benz(a)pyrene exposure in intact controls and animals with desynchronosis.
Shurlygina
A V
AV
Institute of Clinical and Experimental Lymphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. a.v.shurlygina@iph.ma.nsc.ru
Michurina
S V
SV
Verbitskaya
L V
LV
Mel'nikova
E V
EV
Trufakin
V A
VA
D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity*; D021081:Chronobiology Disorders / Q000276:immunology*; D007107:Immune System / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000633:toxicity*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA
D007166:Immunosuppressive Agents; D001564:Benzo(a)pyrene