Antibiotic-related renal failure and cystic fibrosis.
Recently published reports suggest that the combination of aminoglycosides with ceftazidime may increase the risk of renal disease in cystic fibrosis. We describe a case of unusually severe acute tubular necrosis occurring in an adolescent with cystic fibrosis receiving i.v. gentamicin plus ceftazidime and discuss the possible mechanisms.
Kennedy
Sean E
SE
Department of Nephrology, Sydney Children's Hospital, New South Wales, Australia. kennedys@sesahs.nsw.gov.au
Henry
Richard L
RL
Rosenberg
Andrew R
AR
D000293:Adolescent; D000617:Aminoglycosides / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001424:Bacterial Infections / Q000150:complications / Q000188:drug therapy*; D003550:Cystic Fibrosis / Q000150:complications*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D009517:New South Wales; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000139:chemically induced* / Q000628:therapy
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D004338:Drug Combinations