title: Synthesis of protected gamma-carboxyglutamates and gamma-acylglutamates by rearrangement of N,N-diacylglutamates.
abstract: A new method for gamma-acylation of protected glutamic acids, involving intramolecular rearrangement of an acyl urethane, has been devised to prepare the protected gamma-carboxyglutamates 7, 9 and 11 and the protected 4-acylglutamates 15 and 22 from N,N-bisurethanes or N-acyl-N-urethanes of general structure 1. When the formyl-urethane 17 was used in the reaction, then the intermediate 18 in the intramolecular rearrangement was obtained.
authors: Department of Chemistry, University of Sussex, Falmer, Brighton, UKBN1 9QJ.
authors: Anthony G
authors: AG
authors: Avent
authors: Heather M E
authors: HM
authors: Duggan
authors: Douglas W
authors: DW
authors: Young