Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1.
The C-terminal PDZ ligand of the AMPA receptor GluR1 subunit may be important for expression of CA1 hippocampal long-term potentiation. To test this directly in vivo, we generated a knock-in mouse lacking the last seven residues of GluR1, comprising the PDZ ligand. This deletion did not affect basal GluR1 synaptic localization, basal synaptic transmission, long-term potentiation or long-term depression, indicating that the ligand is not required for CA1 hippocampal synaptic plasticity.
Kim
Chong-Hyun
CH
Department of Neuroscience and Howard Hughes Medical Institute, The Johns Hopkins University, Baltimore, Maryland 21205, USA.
Takamiya
Kogo
K
Petralia
Ronald S
RS
Sattler
Rita
R
Yu
Sandy
S
Zhou
Weiguo
W
Kalb
Robert
R
Wenthold
Robert
R
Huganir
Richard
R
D000818:Animals; D006624:Hippocampus / Q000502:physiology*; D008024:Ligands; D017774:Long-Term Potentiation / Q000502:physiology*; D036881:Long-Term Synaptic Depression / Q000502:physiology; D051379:Mice; D008822:Mice, Transgenic; D009473:Neuronal Plasticity / Q000502:physiology; D018091:Receptors, AMPA / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology; D014018:Tissue Distribution
D008024:Ligands; D018091:Receptors, AMPA