title: Application of triazine "superactive esters" in the repetitive synthesis of oligopeptides. Part 1. Synthesis of [54-59] fragment of human beta-casein.
abstract: A new synthetic protocol which considerably improves the classic REMA procedure is proposed herein. The offered modification is based on the application of triazine "superactive esters" as the superior substitutes for mixed anhydrides, which have been used as acylating reagent in the classic procedure. The improved repetitive procedure in solution was applied to the preparation of [54-59] fragment of human beta-casein. The structure and high purity of the intermediates, as well as of the final products, was confirmed by FAB-MS, 1H-NMR and HPLC.
authors: Institute of Organic Chemistry, Technical University of Lódź, 116 Zeromskiego Str., 90-924 Lódź, Poland. kaminsz@mail.p.lodz.pl
authors: Zbigniew J
authors: ZJ
authors: Kamiński
authors: Bashar
authors: B
authors: Saleh
authors: Beata
authors: B
authors: Kolesińska
authors: Adam
authors: A
authors: Redliński
authors: Juliusz
authors: J
authors: Rudziński
mesh_terms: D000812:Anhydrides; D002364:Caseins / Q000138:chemical synthesis*; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D009842:Oligopeptides / Q000138:chemical synthesis*; D010446:Peptide Fragments / Q000138:chemical synthesis; D014227:Triazines / Q000737:chemistry*
chemical_list: D000812:Anhydrides; D002364:Caseins; D007202:Indicators and Reagents; D009842:Oligopeptides; D010446:Peptide Fragments; D014227:Triazines