Adaptive exponential integrate-and-fire model as an effective description of neuronal activity.
We introduce a two-dimensional integrate-and-fire model that combines an exponential spike mechanism with an adaptation equation, based on recent theoretical findings. We describe a systematic method to estimate its parameters with simple electrophysiological protocols (current-clamp injection of pulses and ramps) and apply it to a detailed conductance-based model of a regular spiking neuron. Our simple model predicts correctly the timing of 96% of the spikes (+/-2 ms) of the detailed model in response to injection of noisy synaptic conductances. The model is especially reliable in high-conductance states, typical of cortical activity in vivo, in which intrinsic conductances were found to have a reduced role in shaping spike trains. These results are promising because this simple model has enough expressive power to reproduce qualitatively several electrophysiological classes described in vitro.
Brette
Romain
R
Dept. d'Informatique, Equipe Odyssée, Ecole Normale Supérieure, 45 rue d'Ulm, 75230 Paris Cedex 05, France. brette@di.ens.fr
Gerstner
Wulfram
W
D000200:Action Potentials / Q000502:physiology*; D000222:Adaptation, Physiological / Q000502:physiology; D000818:Animals; D002462:Cell Membrane / Q000502:physiology*; D003198:Computer Simulation; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology*; D006801:Humans; D008564:Membrane Potentials / Q000502:physiology*; D008959:Models, Neurological; D009473:Neuronal Plasticity / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*