Physiologically stable vanadium(IV) porphyrins as a new class of anti-HIV agents.
The water soluble oxovanadium(IV) tetraarylporphyrin has demonstrated excellent solution stability against glutathione reduction and high potency (5 microM, 97% inhibition) in inhibiting HIV-1 replication in Hut/CCR5 cells.
Wong
Suk-Yu
SY
Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, SAR, China.
Wai-Yin Sun
Raymond
R
Chung
Nancy P-Y
NP
Lin
Chen-Lung
CL
Che
Chi-Ming
CM
D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D004355:Drug Stability; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D008665:Metalloporphyrins / Q000737:chemistry / Q000494:pharmacology*; D010084:Oxidation-Reduction; D019713:Receptors, CCR5; D012995:Solubility; D017968:Vanadium Compounds / Q000737:chemistry / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
D019380:Anti-HIV Agents; D008665:Metalloporphyrins; D019713:Receptors, CCR5; D017968:Vanadium Compounds; D005978:Glutathione