title: Coffee consumption and breast cancer risk among BRCA1 and BRCA2 mutation carriers.
abstract: Although there are several plausible biologic mechanisms whereby coffee consumption might influence the risk of breast cancer, epidemiologic evidence is limited. We assessed the association between coffee consumption and breast cancer risk among high-risk women who carry BRCA mutations. We performed a matched case-control analysis on 1,690 women with a BRCA1 or BRCA2 mutation from 40 centers in 4 countries. Average lifetime coffee consumption was estimated via a self-administered questionnaire. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression. After adjustment for potential confounders, the ORs for breast cancer in BRCA carriers who habitually drank 0, 1-3, 4-5 and 6 or more cups of coffee were 1.00, 0.90 (95% CI 0.72-1.12), 0.75 (95% CI 0.47-1.19) and 0.31 (95% CI 0.13-0.71; p-trend = 0.02). The effect was limited to the consumption of caffeinated coffee. These results suggest that among women with BRCA gene mutation, coffee consumption is unlikely to be harmful and that high levels of consumption may in fact be related to reduced breast cancer risk.
authors: Epidemiology Research Unit, Research Centre, Centre Hospitalier de 'Universitaire de Montréal, CHUM Hôtel-Dieu, Montréal, Canada.
authors: André
authors: A
authors: Nkondjock
authors: Parviz
authors: P
authors: Ghadirian
authors: Joanne
authors: J
authors: Kotsopoulos
authors: Jan
authors: J
authors: Lubinski
authors: Henry
authors: H
authors: Lynch
authors: Charmaine
authors: C
authors: Kim-Sing
authors: Douglas
authors: D
authors: Horsman
authors: Barry
authors: B
authors: Rosen
authors: Claudine
authors: C
authors: Isaacs
authors: Barbara
authors: B
authors: Weber
authors: William
authors: W
authors: Foulkes
authors: Peter
authors: P
authors: Ainsworth
authors: Nadine
authors: N
authors: Tung
authors: Andrea
authors: A
authors: Eisen
authors: Eitan
authors: E
authors: Friedman
authors: Charis
authors: C
authors: Eng
authors: Ping
authors: P
authors: Sun
authors: Steven A
authors: SA
authors: Narod
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control*; D016022:Case-Control Studies; D003069:Coffee; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D012044:Regression Analysis; D012307:Risk Factors
chemical_list: D003069:Coffee