title: An elevated PSA, which normalizes, does not exclude the presence of prostate cancer.
abstract: The purpose of this study was to determine the incidence of prostate cancer in patients who have an elevated referral prostate-specific antigen (PSA), which subsequently falls to within their normal age-specific reference range prior to prostate biopsy. The study demonstrated that of the 160 patients recruited, 21 (13%) had a repeat PSA level which had fallen back to within their normal range. Five of these 21 patients (24%) were diagnosed with prostate cancer following biopsy, two of whom had a benign prostate examination. The study, therefore, demonstrates that normalisation of the PSA level prior to biopsy does not exclude the presence of prostate cancer even when the prostate feels benign.
authors: The Harold Hopkins Department of Urology, Royal Berkshire Hospital, Reading, UK. boddyjane@hotmail.com
authors: J L
authors: JL
authors: Boddy
authors: D J
authors: DJ
authors: Pike
authors: S
authors: S
authors: Al-Hayek
authors: N
authors: N
authors: Shaida
authors: P R
authors: PR
authors: Malone
mesh_terms: D000368:Aged; D000375:Aging / Q000097:blood; D001706:Biopsy; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000473:pathology; D012016:Reference Values
chemical_list: D017430:Prostate-Specific Antigen