Histological classification of 1,025 cases of Hodgkin's lymphoma from the State of São Paulo, Brazil.
OBJECTIVE
It is currently asserted that, in industrialized countries, nodular sclerosis is the most frequent type of Hodgkin's lymphoma, in contrast to developing countries, where mixed cellularity and lymphocyte depletion are more frequently seen. The objective was to review histological data from cases of Hodgkin's lymphoma from São Paulo and Campinas cities.


METHODS
Cross-sectional histopathological analysis, in four university hospitals and one cancer care center.


METHODS
1,025 cases diagnosed as Hodgkin's lymphoma between 1990 and 2000 were collected from five institutions; 631 of them (61.5%) had been immunophenotyped using antibodies to CD20, CD3, CD15 and CD30. The relative frequencies of histological types (as informed by the contributing authors, who are hematopathologists in their institutions) were determined according to age and gender.


RESULTS
The Hodgkin's lymphoma types were distributed as follows: lymphocyte predominance 4.8%, nodular sclerosis 69.2%, mixed cellularity 21.1% and lymphocyte depletion 4.6%.


CONCLUSIONS
The controversy regarding the frequencies of Hodgkin's lymphoma types within the Brazilian setting seems to be due to the small number of cases in previous studies. The present data show a picture close to the situation in the industrialized countries.
Vassallo
José
J
Universidade Estadual de Campinas, Campinas, São Paulo, Brazil. glaujv@fcm.unicamp.br
Paes
Roberto Pinto
RP
Soares
Fernando Augusto
FA
Menezes
Yara
Y
Aldred
Vera
V
Ribeiro
Karina de Cássia Braga
Kde C
Alves
Antonio Correa
AC
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D001938:Brazil; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006689:Hodgkin Disease / Q000145:classification / Q000473:pathology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D017678:Sex Distribution
D014408:Biomarkers, Tumor