Antiviral activity of liposomal preparations of antibiotic geliomycin.
A liposomal preparation with maximally possible content of incorporated geliomycin was obtained. Its cytotoxicity was studied in a culture of human embryonal diploid fibroblasts. Antiviral activity was studied on a model of cytomegaloviral infection in vitro by the capacity to plaque formation. Liposomal geliomycin was 10-fold less toxic for human cells than the solution of the antibiotic in DMSO and exhibited antiviral activity towards cytomegaloviral infection at a concentration of 0.042 microg/ml.
Podol'skaya
S V
SV
M. V. Lomonosov Moscow State Academy of Fine Chemical Technology Russian Academy of Medical Sciences, Moscow.
Naryshkina
N A
NA
Sorokoumova
G M
GM
Kaplun
A P
AP
Fedorova
N E
NE
Medzhidova
A A
AA
Kuts
A A
AA
Shvets
V I
VI
D000998:Antiviral Agents / Q000633:toxicity*; D001580:Benzopyrenes / Q000008:administration & dosage / Q000633:toxicity; D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008081:Liposomes; D010948:Viral Plaque Assay
D000998:Antiviral Agents; D001580:Benzopyrenes; D008081:Liposomes; C018379:resistomycin