Antileishmanial agents part-IV: synthesis and antileishmanial activity of novel terpenyl pyrimidines.
Some novel N- and O-substituted terpenyl pyrimidines 4 (a-j) have been synthesized and screened for in vitro antileishmanial activity profile in promastigote model. Some of the compounds exhibited 100% inhibition at 10 microg ml(-1) concentration.
Chandra
Naveen
N
Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India.
Ramesh
Ashutosh
Goyal
Neena
N
Suryawanshi
S N
SN
Gupta
Suman
S
D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007891:Leishmania / Q000187:drug effects* / Q000254:growth & development; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000981:Antiprotozoal Agents; D011743:Pyrimidines; D013729:Terpenes