The role of body weight in oral contraceptive failure: results from the 1995 national survey of family growth.
OBJECTIVE
Many unintended pregnancies occur in women who use contraception. We conducted this study to determine if increasing body weight is associated with oral contraceptive (OC) failure.


METHODS
This retrospective cohort study consists of the 1916 women who reported using OCs in January 1993 and provided complete covariate information on the 1993 National Health Interview Survey and 1995 National Survey of Family Growth. Body weight and body mass index (BMI) were self-reported in 1993. The outcome was defined to be any conception occurring in women reporting OC use during the month of conception. Cox proportional hazards models were used to model the body weight/BMI-OC failure association.


RESULTS
Women with a BMI >/= 30 had a statistically significant increased risk of having an OC failure as compared to women with BMIs of 20 to 24.9 (HR=1.80, 95% CI, 1.01, 3.20). However, after adjustment for age, marital status, education, poverty, race/ethnicity, parity, and dual method use, this increased risk was attenuated and no longer statistically significant (HR=1.51, 95% CI, 0.81, 2.82). Increasing body weight was not associated with an increased risk of OC failure in the unadjusted or adjusted models.


CONCLUSIONS
We did not find a strong or statistically significant association between increasing body weight/BMI and OC failure among this population of women. Prospective studies specifically designed to examine this association are needed to determine if heavier women should be advised to use a contraceptive method other than OCs to prevent pregnancy.
Brunner
Larissa R
LR
Department of Epidemiology, Emory University, Atlanta, GA 30322, USA. lbrunne@sph.emory.edu
Hogue
Carol J
CJ
D000328:Adult; D001835:Body Weight / Q000187:drug effects / Q000502:physiology*; D003276:Contraceptives, Oral / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005190:Family; D005260:Female; D006306:Health Surveys; D006801:Humans; D011247:Pregnancy; D049168:Pregnancy, Unplanned / Q000187:drug effects / Q000502:physiology*; D012189:Retrospective Studies; D018570:Risk Assessment; D017211:Treatment Failure; D014481:United States; D015430:Weight Gain / Q000187:drug effects / Q000502:physiology
D003276:Contraceptives, Oral