title: Serotonin uptake to lymphocytes of patients with social phobia compared to normal individuals.
abstract: Several trials have indicated that selective serotonin reuptake inhibitors (SSRIs) are most efficient in the treatment of social phobia (SP). The activity of the serotonin transporter (5-HTT), as determined by [3H]5-HT uptake to blood lymphocytes, was measured in 15 drug-free patients with generalized SP (7M/8F, aged 21-37 years) and compared to 18 healthy control subjects (10M/8F, aged 21-32 years). The maximum uptake velocity (Vmax) of [3H]5-HT to fresh lymphocytes and the affinity (Km) of the 5-HTT were similar in the two groups (295+/-155 versus 227+/-117 pmol/min/mg protein and 767+/-425 versus 709+/-408 nM, respectively). This study suggests that the functioning of lymphocyte 5-HTT is unaltered in SP.
authors: Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors: Tal
authors: T
authors: Barkan
authors: Haggai
authors: H
authors: Hermesh
authors: Sofi
authors: S
authors: Marom
authors: David
authors: D
authors: Gurwitz
authors: Abraham
authors: A
authors: Weizman
authors: Moshe
authors: M
authors: Rehavi
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010698:Phobic Disorders / Q000378:metabolism / Q000473:pathology*; D012701:Serotonin / Q000378:metabolism* / Q000493:pharmacokinetics; D012720:Severity of Illness Index; D014316:Tritium / Q000378:metabolism / Q000493:pharmacokinetics
chemical_list: D014316:Tritium; D012701:Serotonin