title: The impact of asthma and aspirin sensitivity on quality of life of patients with nasal polyposis.
abstract: BACKGROUND
  Nasal polyposis is not a life-threatening disease but may have a great impact on patient's quality of life.
  
  
  OBJECTIVE
  To investigate the impact of nasal polyps on quality of life compared with the Spanish general population using the SF-36 questionnaire; and to evaluate the impact of asthma and aspirin sensitivity on quality of life in patients with nasal polyposis.
  
  
  METHODS
  We included 130 patients with nasal polyposis and evaluated nasal symptom, CT scan, polyp size, and quality of life.
  
  
  RESULTS
  In comparison with the Spanish general population, patients with nasal polyposis had worse scores on all SF-36 domains except for physical functioning. Asthmatic patients with nasal polyposis had worse quality of life than nonasthmatic patients on role physical, body pain, and vitality (p < 0.05). The authors found no significant differences on quality of life, nasal symptoms, polyp size, and CT scan scores between patients with aspirin-tolerant and aspirin-sensitive asthma.
  
  
  CONCLUSIONS
  These results suggest that nasal polyposis has a considerable impact on quality of life. Moreover, asthma but not aspirin sensitivity has an additional negative impact on the quality of life of patients with nasal polyposis.
authors: Rhinology Unit, Department of Otorhinolaryngology (ICEMEQ), University of Barcelona, Spain.
authors: Isam
authors: I
authors: Alobid
authors: Pedro
authors: P
authors: Benítez
authors: Manuel
authors: M
authors: Bernal-Sprekelsen
authors: José María
authors: JM
authors: Guilemany
authors: Cesar
authors: C
authors: Picado
authors: Joaquim
authors: J
authors: Mullol
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015508:Nasal Obstruction / Q000145:classification / Q000209:etiology*; D009298:Nasal Polyps / Q000150:complications*; D011446:Prospective Studies; D011788:Quality of Life; D018434:Sickness Impact Profile; D013030:Spain
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin