Continuous, intra-articular infusion of bupivacaine after total-knee arthroplasty may lead to potentially toxic serum levels of local anesthetic.
Hoeft
Mark A
MA
Rathmell
James P
JP
Dayton
Michael R
MR
Lee
Peter
P
Howe
James G
JG
Incavo
Stephen J
SJ
Lawlis
John F
JF
D000779:Anesthetics, Local / Q000008:administration & dosage*; D019645:Arthroplasty, Replacement, Knee; D002045:Bupivacaine / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood; D006801:Humans; D007270:Injections, Intra-Articular; D010149:Postoperative Pain / Q000188:drug therapy*
D000779:Anesthetics, Local; D002045:Bupivacaine