Preparation of acrylic bone cements for vertebroplasty with bismuth salicylate as radiopaque agent.
One of the problems of percutaneous vertebroplasty attributed to the use of acrylic cements is related to the radiopacity of the formulation. The use of bismuth salicylate as the radiopaque agent is proposed in this work, taking into account the high radiopacity of organobismuth compounds used in dental applications and the possible analgesic effect of salicylic acid. Various cements formulated with this compound (some of them modified with polyethylene oxide) were examined. Setting parameters, mechanical properties, rheological behaviour, injectability, radiopacity and biocompatibility were studied for a variety of formulations, showing that the cement formulations containing bismuth salicylate have a higher radiopacity and better injection properties than commercial bone cement preparations and present good mechanical properties.
Hernández
Lidia
L
Dpto Ciencia y Tecnología de Polímeros, POLYMAT (Institute of Polymeric Materials), Facultad de Química, Universidad del País Vasco, Apdo. 1072, 20080-San Sebastián, Spain.
Fernández
Mar
M
Collía
Francisco
F
Gurruchaga
Mariló
M
Goñi
Isabel
I
D001672:Biocompatible Materials / Q000737:chemistry*; D001843:Bone Cements / Q000737:chemistry*; D018786:Bone Substitutes / Q000737:chemistry; D003287:Contrast Media / Q000494:pharmacology; D008422:Materials Testing; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D019904:Polymethyl Methacrylate / Q000737:chemistry* / Q000494:pharmacology*; D012212:Rheology; D012459:Salicylates / Q000494:pharmacology*; D020156:Salicylic Acid / Q000737:chemistry*; D013131:Spine / Q000473:pathology*; D013314:Stress, Mechanical; D013696:Temperature; D013718:Tensile Strength; D013997:Time Factors; D014965:X-Rays
D001672:Biocompatible Materials; D001843:Bone Cements; D018786:Bone Substitutes; D003287:Contrast Media; D012459:Salicylates; D011092:Polyethylene Glycols; D019904:Polymethyl Methacrylate; C496893:Bismuth Salicylate; D020156:Salicylic Acid