Procedure for the parallel preparation of 3-imidazo[1,2-a]pyridin-3-yl-propionic acid derivatives involving Meldrum's acid.
We describe here an efficient and versatile method for the preparation of 3-imidazo[1,2-a]pyridin-3-yl-propionic acids involving, as a key step, a three-component Michael-type reaction. The extended and validated procedure allowed us to prepare various acids with three diversity points. The method was easily adaptable for parallel synthesis and an approximately 2000-membered 3-imidazo[1,2-a]pyridin-3-yl-propionic acid amide library was prepared in a semiautomated manner.
Gerencsér
János
J
ComGenex Inc., H-1027, Budapest, Bem rkp. 33-34, Hungary.
Panka
Gábor
G
Nagy
Tamás
T
Egyed
Orsolya
O
Dormán
György
G
Urge
László
L
Darvas
Ferenc
F
D020650:Combinatorial Chemistry Techniques; D004146:Dioxanes / Q000737:chemistry*; D015394:Molecular Structure; D011422:Propionates / Q000737:chemistry*
D004146:Dioxanes; D011422:Propionates; C076489:Meldrum's acid; C029658:propionic acid