A degenerative encephalomyelopathy in 7 Kuvasz puppies.
Seven Kuvasz puppies from 2 same-parentage litters developed weakness and ataxia. Six necropsied dogs had lesions in caudate nucleus, cerebellar nuclei and folia, and spinal cord. Lesions seen were felt to be familial or due to the effects of an amprolium-induced thiamine deficiency on the developing brains of these puppies.
Hazlett
Murray J
MJ
Animal Health Laboratory, University of Guelph, Guelph, Ontario. mhazlett@uoguelph.ca
Smith-Maxie
Laura L
LL
de Lahunta
Alexander
A
D000670:Amprolium / Q000633:toxicity*; D000818:Animals; D000831:Animals, Newborn; D000981:Antiprotozoal Agents / Q000633:toxicity*; D001259:Ataxia / Q000209:etiology / Q000662:veterinary; D001921:Brain / Q000473:pathology; D002493:Central Nervous System Diseases / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D005260:Female; D008297:Male; D013116:Spinal Cord / Q000473:pathology; D013832:Thiamine Deficiency / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*
D000981:Antiprotozoal Agents; D000670:Amprolium