title: Clinical manifestations of mannan-binding lectin deficiency.
abstract: Mannan-binding lectin (MBL) is a plasma protein of the innate immune system with the ability to initiate antimicrobial and inflammatory actions. MBL deficiency is common. More than 10% of the general population may, depending on definition, be classified as MBL deficient, underlining the redundancy of the immune system. Ongoing research attempt to illuminate at which conditions MBL deficiency may lead to disease. With examples, this review illustrates the diversity of results obtained so far.
authors: Department of Medical Microbiology and Immunology, University of Aarhus, DK8000 Denmark. st@microbiology.au.dk
authors: S
authors: S
authors: Thiel
authors: P D
authors: PD
authors: Frederiksen
authors: J C
authors: JC
authors: Jensenius
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D001798:Blood Proteins / Q000172:deficiency* / Q000627:therapeutic use; D006801:Humans; D007113:Immunity, Innate; D007239:Infections / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D037601:Mannose-Binding Lectin / Q000172:deficiency* / Q000627:therapeutic use; D051379:Mice; D018345:Mice, Knockout; D018746:Systemic Inflammatory Response Syndrome / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D014652:Vascular Diseases / Q000235:genetics / Q000473:pathology* / Q000628:therapy
chemical_list: D001798:Blood Proteins; C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin