The effect of chronic physical exercise on succinic dehydrogenase activity in the heart muscle of old rats.
Succinic dehydrogenase (SDH) activity, preferentially evidenced by cytochemical methods, has been measured by computer-assisted morphometry in the heart muscle of old sedentary and age-matched animals chronically undergone physical exercise (20 min, twice a day, 5 days a week). The area of the SDH-positive mitochondria (MA) and the overall area of the cytochemical precipitates due to SDH activity (PA) were semiautomatically measured and the ratios PA/MA as well as MA/overall myocardial tissue area analysed (MA/TA) were the parameters taken into account. No significant difference was found between the two groups investigated as regards PA/MA, whereas the MA/TA value is significantly increased in the animals undergone physical training. The present findings document that chronic physical exercise significantly increases the overall mitochondrial area involved in energy provision in the old myocardial tissue. Considering that myocardial function highly relies on mitochondrial metabolism, our results support a beneficial effect of chronic physical exercise on the old heart muscle.
Balietti
Marta
M
INRCA Research Department, Neurobiology of Aging Laboratory, Ancona, Italy.
Fattoretti
Patrizia
P
Skalicky
Monika
M
Viidik
Andrus
A
Giorgetti
Belinda
B
Grossi
Yessica
Y
Bertoni-Freddari
Carlo
C
D000375:Aging / Q000502:physiology*; D000818:Animals; D001835:Body Weight / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D004789:Enzyme Activation; D005081:Exercise Therapy / Q000379:methods*; D006321:Heart / Q000502:physiology*; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D010805:Physical Conditioning, Animal / Q000379:methods*; D005082:Physical Exertion / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013385:Succinate Dehydrogenase / Q000502:physiology*
D013385:Succinate Dehydrogenase