title: Kadsuphilactones A and B, two new triterpene dilactones from kadsuraphilippinensis.
abstract: [structure: see text]. Two novel triterpene dilactones, kadsuphilactones A (1) and B (2), were isolated from the Taiwanese medicinal plant Kadsura philippinensis. The structures of 1 and 2 were elucidated on the basis of extensive spectroscopic methods, including two-dimensional NMR techniques, and confirmed by X-ray crystallographic analysis. Kadsuphilactone B (2) exhibited in vitro anti-HBV activity with IC(50) values of 6 microg/mL by HBsAg enzyme immunoassay.
authors: Department of Marine Resources, National Sun Yat-Sen University, Taiwan, Republic of China. ycshen@mail.nsysu.edu.tw
authors: Ya-Ching
authors: YC
authors: Shen
authors: Yu-Chi
authors: YC
authors: Lin
authors: Michael Y
authors: MY
authors: Chiang
authors: Sheau Farn
authors: SF
authors: Yeh
authors: Yuan-Bin
authors: YB
authors: Cheng
authors: Chia-Ching
authors: CC
authors: Liao
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D006515:Hepatitis B virus / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D032135:Kadsura / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D007783:Lactones; D014315:Triterpenes; C510337:kadsuphilactone A; C510338:kadsuphilactone B