[Experimental study of protective effect of pueraria compound on the cerebral ischemic injury].
OBJECTIVE
To discuss the protective effects of pueraria compound on the cerebral ischemic injury.


METHODS
Using the middle cerebral artery occlusion model (MCAO) in rats and cerebral ischemia-reperfusion models in gerbils and mice, we investigated the influence of pueraria compound on the brain water content and the infarct size, the cerebral apoplexy exponent, the contents of lactic acid (LA) and lipid peroxide (LPO), the activities of lactic dehydrogenase (LDH), glutathione peroxidase (GPx) and Na+ -K+ -ATPase.


RESULTS
Pueraria compound obviously reduced the brain water content and the infrarct size in MCAO, improved motor abilities in the cerebral ischemia-reinfusion model of gerbils, decreased the contents of LA and LPO and increased the activities of LDH, GPx and Na+ -K+ -ATPase in cerebral ischemia-reinfusion model of mice.


CONCLUSIONS
Pueraria compound has the function of antioxidation and protective effect on ischemic brain tissue.
Zhao
Yong
Y
Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700, China.
Du
Gui-you
GY
Cui
Hai-feng
HF
Cao
Chun-yu
CY
Wang
Xiu-rong
XR
Zhang
Chun-ying
CY
D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D002545:Brain Ischemia / Q000378:metabolism* / Q000473:pathology; D004338:Drug Combinations; D005849:Gerbillinae; D005979:Glutathione Peroxidase / Q000378:metabolism; D007529:Isoflavones / Q000302:isolation & purification / Q000494:pharmacology*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D019344:Lactic Acid / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D051379:Mice; D018696:Neuroprotective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D029908:Pueraria / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000378:metabolism* / Q000473:pathology; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013025:Glycine max / Q000737:chemistry
D000975:Antioxidants; D004338:Drug Combinations; D007529:Isoflavones; D008054:Lipid Peroxides; D018696:Neuroprotective Agents; D019344:Lactic Acid; D007770:L-Lactate Dehydrogenase; D005979:Glutathione Peroxidase; D000254:Sodium-Potassium-Exchanging ATPase; C033607:puerarin