[Copaiba oil effect on urea and creatinine serum levels in rats submitted to kidney ischemia and reperfusion syndrome].
OBJECTIVE
To evaluate the copaiba oil effect on urea and creatinine levels in rats submitted to kidney ischemia and reperfusion syndrome.


METHODS
Eighteen Wistar rats (Rattus norvegicus albinus), aged between 90 and 120 days, weight between 200 g and 250 g, were allocated in 2 groups (n=9) and submitted to 50 minutes of renal ischemia and reperfusion and treated or not with copaiba oil (0.63 ml/kg daily seven days before ischemia). The nitrogen excrements were assessed at 24, 48 and 72 hours after ischemia period.


RESULTS
The urea serum level was smaller (p d" 0,05) at 24 and 48 hours, and the creatinine serum level was smaller at 48 hours in animals treated with copaiba oil (GIRC) than the GIR.


CONCLUSIONS
The copaiba oil decreased significantly the urea serum level at 24 and 48 hours and the creatinine level at 48 hours after kidney ischemia and reperfusion in rats.
Brito
Marcus Vinicius Henriques
MV
Disciplina Técnica Operatória, Cirurgia Experimental e Anestesiologia, UEPA. mnbrito@amazon.com.br
de Moreira
Raphael Jesus
RJ
Tavares
Marcelo Luiz Couto
ML
Carballo
Mariela Carolina Santos
MC
Carneiro
Thiago Xavier
TX
dos Santos
Alex de Assis Santos
Ade A
D000818:Animals; D001453:Balsams / Q000494:pharmacology*; D003404:Creatinine / Q000097:blood*; D005260:Female; D007511:Ischemia / Q000097:blood*; D007668:Kidney / Q000098:blood supply* / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D015424:Reperfusion; D013997:Time Factors; D014508:Urea / Q000097:blood*
D001453:Balsams; C114971:copaiba balsam; D014508:Urea; D003404:Creatinine