Subcutaneous ivermectin as a safe salvage therapy in Strongyloides stercoralis hyperinfection syndrome: a case report.
Strongyloides stercoralis hyperinfection syndrome due to the acceleration of the autoinfective cycle of the nematode is a life-threatening form of the infection occurring in immunocompromised hosts. Intestinal ileus, which is commonly encountered in this form, may reduce the bioavailability and thus the efficacy of oral anthelminthic drugs used in the treatment of the S. stercoralis hyperinfection syndrome. We report the efficacy and safety of subcutaneous administration of ivermectin in a patient infected with human T cell lymphotropic virus type I with S. stercoralis hyperinfection syndrome who was unresponsive to an oral combination of ivermectin and albendazole.
Pacanowski
Jerome
J
Départements de Microbiologie, Soins Intensifs de Pneumologie, et d'Oncologie Médicale, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, Pairs, France.
Santos
Marie Dos
MD
Roux
Antoine
A
LE Maignan
Christine
C
Guillot
Jacques
J
Lavarde
Veronique
V
Cornet
Muriel
M
D000328:Adult; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D007560:Cote d'Ivoire / Q000208:ethnology; D017809:Fatal Outcome; D005602:France; D006801:Humans; D007559:Ivermectin / Q000627:therapeutic use*; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications*; D008297:Male; D017171:Strongyloides stercoralis; D013322:Strongyloidiasis / Q000150:complications / Q000188:drug therapy*
D000871:Anthelmintics; D007559:Ivermectin