title: [Antisense oligonucleotides inhibiting ribosomal functions in mycobacteria].
abstract: We studied the binding of antisense oligonucleotides with 23S rRNA of mycobacteria and E. coli and identified oligonucleotides with selective affinity to the alpha-sarcin loop region of 23S rRNA of M. tuberculosis and to 70S ribosomes of M. smegmatis. These oligonucleotides proved to selectively inhibit protein synthesis on M. smegmatis ribosomes.
authors: Iu N
authors: IuN
authors: Demchenko
authors: M A
authors: MA
authors: Zenkova
authors: V V
authors: VV
authors: Vlasov
mesh_terms: D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D009161:Mycobacterium / Q000187:drug effects* / Q000235:genetics; D009690:Nucleic Acid Conformation; D016376:Oligonucleotides, Antisense / Q000235:genetics / Q000494:pharmacology*; D014176:Protein Biosynthesis / Q000187:drug effects* / Q000235:genetics; D012338:RNA, Ribosomal, 23S / Q000037:antagonists & inhibitors*; D012270:Ribosomes / Q000187:drug effects*
chemical_list: D016376:Oligonucleotides, Antisense; D012338:RNA, Ribosomal, 23S