Mouse mutants as models for congenital retinal disorders.
Animal models provide a valuable tool for investigating the genetic basis and the pathophysiology of human diseases, and to evaluate therapeutic treatments. To study congenital retinal disorders, mouse mutants have become the most important model organism. Here we review some mouse models, which are related to hereditary disorders (mostly congenital) including retinitis pigmentosa, Leber's congenital amaurosis, macular disorders and optic atrophy.
Dalke
Claudia
C
GSF-National Research Center for Environment and Health, Institute of Developmental Genetics, D-85764 Neuherberg, Germany. dalke@gsf.de
Graw
Jochen
J
D000818:Animals; D015870:Gene Expression; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008817:Mice, Mutant Strains; D023421:Models, Animal; D012160:Retina / Q000378:metabolism; D012164:Retinal Diseases / Q000151:congenital* / Q000378:metabolism