title: Peripheral T-cell lymphoma together with myelofibrosis with elevated plasma transforming growth factor-beta1.
abstract: Myelofibrosis is usually observed in myeloproliferative disorders, such as chronic myeloid leukemia. However, there are only a few reports showing an association between T-cell lymphoma and myelofibrosis. We report a case of peripheral T-cell lymphoma, unspecified (diffuse large cell) type, involving the bone marrow that was associated with severe myelofibrosis. In the present case, the plasma concentration of transforming growth factor-beta1 (TGF-beta1) was increased to 8.95 ng/ml (normal range: 1.56-3.24 ng/ml). No lymphadenopathy or skin lesions were observed during the entire clinical course. Although the mechanism of secondary myelofibrosis is still unclear, elevated plasma TGF-beta1 might be involved in the pathogenesis of bone marrow fibrosis in the present case.
authors: First Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan.
authors: Seiichi
authors: S
authors: Okabe
authors: Keisuke
authors: K
authors: Miyazawa
authors: Tomotaka
authors: T
authors: Iguchi
authors: Masahiko
authors: M
authors: Sumi
authors: Tomoiku
authors: T
authors: Takaku
authors: Yoshikazu
authors: Y
authors: Ito
authors: Yukihiko
authors: Y
authors: Kimura
authors: Hiromi
authors: H
authors: Serizawa
authors: Kiyoshi
authors: K
authors: Mukai
authors: Kazuma
authors: K
authors: Ohyashiki
mesh_terms: D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D016411:Lymphoma, T-Cell, Peripheral / Q000097:blood / Q000150:complications* / Q000628:therapy; D008297:Male; D055728:Primary Myelofibrosis / Q000097:blood / Q000150:complications* / Q000473:pathology; D016212:Transforming Growth Factor beta / Q000032:analysis*; D053773:Transforming Growth Factor beta1
chemical_list: C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1