Plasma antigen levels of thrombin-activatable fibrinolysis inhibitor did not differ in patients with or without disseminated intravascular coagulation.
Thrombin-activatable fibrinolysis inhibitor (TAFI) is a carboxypeptidase that downregulates fibrinolysis and might play some roles in the pathogenesis of disseminated intravascular coagulation (DIC). We prospectively examined the plasma TAFI antigen levels in patients highly suspected to be suffering from DIC. Patients were subdivided into overt DIC and non-DIC groups according to a DIC scoring system. The Sepsis-related Organ Failure Assessment (SOFA) scores were concurrently calculated on patients with sepsis. Overall, there were 23 non-DIC patients and 20 patients with overt DIC. Their baseline characteristics were similar, but patients with overt DIC had much more aberrant coagulation tests and higher lactate dehydrogenase levels. However, there was no significant difference between overt DIC and non-DIC patients regarding their TAFI antigen levels [median/interquartile range (IQR) 74.41/13.98 and 75.29/15.16, respectively, p=0.543]. On regression analysis, TAFI antigen levels were not correlated with either C-reactive protein levels or various coagulation test results. In patients with sepsis (n=31), TAFI levels among three risk groups stratified by low (<or=5), intermediate (6-10), and high (>or=11) SOFA scores were not statistically disparate (median/IQR 65.24/15.14, 74.63/13.79, and 75.29/21.51, respectively, p=0.684), either. Our result indicated that plasma TAFI antigen levels did not vary significantly between patients with or without DIC. Further, they did not possess any correlation with the severity of organ injury in patients with sepsis. The role of TAFI antigen in the pathogenesis of DIC needs further elucidation by future studies.
Chen
Chih-Cheng
CC
Division of Hematology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Lee
Kuan-Der
KD
Gau
Jyh-Pyng
JP
Yu
Yuan-Bin
YB
You
Jie-Yu
JY
Lee
Su-Chung
SC
Hsu
Hui-Chi
HC
Chau
Wing-Keung
WK
Ho
Chao-Hung
CH
D000368:Aged; D000818:Animals; D000941:Antigens / Q000097:blood / Q000276:immunology; D025901:Carboxypeptidase B2 / Q000097:blood* / Q000276:immunology; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000276:immunology; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D051379:Mice; D010949:Plasma / Q000276:immunology / Q000378:metabolism; D011237:Predictive Value of Tests; D011446:Prospective Studies; D051381:Rats; D018805:Sepsis / Q000097:blood / Q000276:immunology; D012772:Shock, Septic / Q000097:blood / Q000276:immunology
D000941:Antigens; D025901:Carboxypeptidase B2