[Tumor cytogenetics].
Cytogenetic analysis by classical chromosome banding, in combination with different fluorescence in situ hybridization (FISH) based methods, including comparative genomic hybridization and multicolour FISH, provides important information concerning the diagnosis, staging and prognosis of, as well as the planning of therapeutic intervention against, leukemias, malignant lymphomas and solid tumors, and may be helpful in monitoring the course of the disease. Cytogenetic methods identify primary chromosome anomalies that are causally involved in the emergence of the disease and its histopathological subtype, as well as secondary anomalies which have an effect upon the course of the disease and the responsiveness to therapy. Tumor cytogenetics is an independent discipline, and by no means only a diagnostic service for, or subdiscipline of, haematological, oncological and pathological fields. It is important, however, to point out that tumor cytogenetics is a cooperation-orientated and interdisciplinary science that deals with its own original questions in collaboration with clinicians, pathologists and molecular geneticists.
Fonatsch
Christa
C
Abteilung für Humangenetik, Klinisches Institut für Medizinische und Chemische Labordiagnostik, Medizinische Universität Wien, Wien, Osterreich. christa.fonatsch@meduniwien.ac.at
Krömer
Elisabeth
E
D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D003299:Cooperative Behavior; D020732:Cytogenetic Analysis; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007938:Leukemia / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D008223:Lymphoma / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D009367:Neoplasm Staging; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D010348:Patient Care Team; D011379:Prognosis