Alpha-synuclein immunohistochemistry in two cases of co-occurring idiopathic Parkinson's disease and motor neuron disease.
We report on two cases of sporadic idiopathic Parkinson's disease with motor neuron disease co-occurring in the same individuals. Pathological analysis revealed the presence of Lewy bodies in brainstem nuclei and basal forebrain consistent with Lewy body disease (LBD), as well as motor neuron degeneration and argyrophilic grain disease. We compared our two cases to all previously published pathological cases of combined LBD and motor neuron degeneration.
Klos
Kevin J
KJ
Department of Neurology, Movement Disorder Division, Mayo Clinic, Rochester, Minnesota, USA.
Josephs
Keith A
KA
Parisi
Joseph E
JE
Dickson
Dennis W
DW
D000368:Aged; D001921:Brain / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D016472:Motor Neuron Disease / Q000150:complications* / Q000378:metabolism* / Q000473:pathology; D016900:Neurofilament Proteins / Q000378:metabolism; D010300:Parkinson Disease / Q000150:complications* / Q000378:metabolism* / Q000473:pathology; D025801:Ubiquitin / Q000378:metabolism; D051844:alpha-Synuclein / Q000378:metabolism*
D016900:Neurofilament Proteins; D025801:Ubiquitin; D051844:alpha-Synuclein