[Soluble tumor necrosis factor related apoptosis inducing ligand (sTRAIL) and clinical outcome of HBV infection in human].
OBJECTIVE
To explore the role of sTRAIL in the pathogenesis of HBV infection in human being.


METHODS
sTRAIL in 153 patients' sera was examined with ELISA. Correlations between sTRAIL and liver functional parameters were analysed.


RESULTS
The levels of sTRAIL in patients with various clinical types of hepatitis B as well as primary hepatocellular carcinoma were all higher than that in normal persons and became almost normal in recovering stage cases. In acute and chronic HBV infection, sTRAIL level was negatively correlated with ALT, AST and total bilirubin levels, and positively correlated with serum albumin.


CONCLUSIONS
The results indicated that higher level of sTRAIL expression is correlated with liver damage, and apoptosis induced by sTRAIL is one of the mechanisms of liver damage in HBV infection.
Yue
Feng-e
FE
Jinan Infectious Diseases Hospital, Jinan 250021, China.
Liu
Dian-yong
DY
Song
Jing
J
Zhang
Li-ning
LN
D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006509:Hepatitis B / Q000097:blood*; D019694:Hepatitis B, Chronic / Q000097:blood*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000821:virology; D008113:Liver Neoplasms / Q000097:blood / Q000821:virology; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin / Q000032:analysis; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000097:blood*; D055815:Young Adult
D012709:Serum Albumin; D053221:TNF-Related Apoptosis-Inducing Ligand; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase