Post-transplant hepatic veno-occlusive disease: pathogenesis, diagnosis and treatment.
Hepatic veno-occlusive disease (VOD) is one of the most important complications following hematopoietic stem cell transplantation (SCT) and is associated with a very high mortality when severe. This review addresses the pathogenesis and clinical features of VOD and outlines the role on endothelial cell injury and risk factors. The current status of research for both treatment and prevention are discussed.
Ho
Vincent
V
Department of Adult Oncology, Division of Hematologic Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
Momtaz
Parisa
P
Didas
Colleen
C
Wadleigh
Martha
M
Richardson
Paul
P
D004730:Endothelium, Vascular / Q000473:pathology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006504:Hepatic Veno-Occlusive Disease / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control / Q000628:therapy; D006801:Humans; D011379:Prognosis; D012307:Risk Factors