Identification of a novel protein for memory regulation in the hippocampus.
Memory formation, maintenance, and retrieval are a dynamic process, reflecting a combined outcome of new memory formation on one hand, and older memory suppression/clearance on the other. Although much knowledge has been gained regarding new memory formation, less is known about the molecular components and processes that serve the function of memory suppression/clearance. Here, we report the identification of a novel protein, termed hippyragranin (HGN), that is expressed in the rat hippocampus and its expression is reduced by hippocampal denervation. Inhibition of HGN by antisense oligonucleotide in area CA1 results in enhanced performance in Morris water maze, as well as elevated long-term potentiation. These results suggest that HGN is involved in negative memory regulation.
Zhang
Xue-Han
XH
Laboratory of Higher Brain Functions, Institute of Neurobiology, Fudan University, Shanghai 200433, China.
Zhang
Hui
H
Tu
Yanyang
Y
Gao
Xiang
X
Zhou
Changfu
C
Jin
Meilei
M
Zhao
Guoping
G
Jing
Naihe
N
Li
Bao-Ming
BM
Yu
Lei
L
D000818:Animals; D001483:Base Sequence; D015536:Down-Regulation / Q000502:physiology; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000378:metabolism; D017774:Long-Term Potentiation / Q000502:physiology; D018782:Maze Learning / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D009419:Nerve Tissue Proteins