title: [Determination of beta-endorphin plasma concentrations in surgical patients with acute abdominal pain].
abstract: Abdominal pain and surgery, frequently associated with this kind of pain, modify plasma levels of stress-hormones and iniciates the response of endogenous analgetic system. The aim of this study was to determine serum concentration of beta-endorphine in patients with acute abdominal pain (n=12), which were surgically treated. Serum concentration of beta-endorphin was measured on five data points: before, during and after surgery. During abdominal surgery serum concentration of beta-endorphin was increased by 7% compared to preoperative period; in postoperative period the concentration continued to rise and remained increased within next hours. The maximal levels of beta-endorphine were not observed during, and immediately after surgery. Postoperatively, between 6 and 8 p.m. on the day of surgery, maximal level of beta-endorphin was noted, which was even ten times higher than to preoperative value. Plasma level of beta-endorphin fell to the baseline values 24 hours after surgery. In conclusion, abdominal surgery induces a postponed (delayed) increase in serum beta-endorphine levels, which are associated with modulation of preoperative, intraoperative and postoperative pain perception.
authors: Institut za anesteziju i reanimaciju, Urgentni Centar, Beograd.
authors: N
authors: N
authors: Popović
authors: Z
authors: Z
authors: Kojić
authors: V
authors: V
authors: Bumbasirević
authors: A
authors: A
authors: Pavlović
authors: B
authors: B
authors: Stefanović
authors: A
authors: A
authors: Karamarkovíc
authors: D
authors: D
authors: Radenković
authors: V
authors: V
authors: Nikolić
mesh_terms: D000006:Abdomen, Acute / Q000097:blood* / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D001615:beta-Endorphin / Q000097:blood*
chemical_list: D001615:beta-Endorphin