title: Impaired virus control and severe CD8+ T-cell-mediated immunopathology in chimeric mice deficient in gamma interferon receptor expression on both parenchymal and hematopoietic cells.
abstract: Bone marrow chimeras were used to determine the cellular target(s) for the antiviral activity of gamma interferon (IFN-gamma). By transfusing such mice with high numbers of naive virus-specific CD8(+) T cells, a system was created in which the majority of virus-specific CD8(+) T cells would be capable of responding to IFN-gamma, but expression of the relevant receptor on non-T cells could be experimentally controlled. Only when the IFN-gamma receptor is absent on both radioresistant parenchymal and bone marrow-derived cells will chimeric mice challenged with a highly invasive, noncytolytic virus completely lack the ability to control the infection and develop severe wasting disease. Further, the study shows that IFN-gamma receptor expression on parenchymal cells in the viscera is more important for virus control than IFN-gamma receptor expression on bone marrow-derived cells.
authors: Institute of Medical Microbiology and Immunology, University of Copenhagen, Denmark.
authors: Pernille
authors: P
authors: Henrichsen
authors: Christina
authors: C
authors: Bartholdy
authors: Jan Pravsgaard
authors: JP
authors: Christensen
authors: Allan Randrup
authors: AR
authors: Thomsen
mesh_terms: D000818:Animals; D001117:Arenaviridae Infections / Q000276:immunology* / Q000473:pathology / Q000821:virology*; D001854:Bone Marrow Cells / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002678:Chimera; D008099:Liver / Q000276:immunology / Q000821:virology; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D017471:Receptors, Interferon / Q000172:deficiency / Q000235:genetics; D013154:Spleen / Q000276:immunology / Q000821:virology; D019282:Wasting Syndrome / Q000473:pathology; D000096743:Interferon gamma Receptor
chemical_list: D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor