Cyclosporin-induced sebaceous hyperplasia in renal transplant patients.
BACKGROUND
Sebaceous hyperplasia is associated with immunosuppressive treatment with cyclosporin in male renal transplant patients. This has not been reported in the local context.


METHODS
This is a report on 2 Chinese renal transplant patients on cyclosporin who developed sebaceous hyperplasia.


RESULTS
One patient was treated with carbon dioxide laser. The result was good and the patient was satisfied with the procedure.


CONCLUSIONS
Cyclosporin-induced sebaceous hyperplasia is likely to be a direct and casual effect of cyclosporin, and to be unrelated to immunosuppressive action. However, further studies are needed to find out whether sebaceous hyperplasia is a dysplastic process or tumour progression in genetically susceptible patients under the effect of immunosuppression.
Pang
S M
SM
Dermatology Unit, Singapore General Hospital, Outram Road, Singapore 169608.
Chau
Y P
YP
D000328:Adult; D016572:Cyclosporine / Q000009:adverse effects; D005145:Face / Q000473:pathology; D006801:Humans; D006965:Hyperplasia; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012627:Sebaceous Glands / Q000187:drug effects / Q000473:pathology*; D017444:Skin Diseases, Papulosquamous / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology
D007166:Immunosuppressive Agents; D016572:Cyclosporine