title: A simple and fast method for the preparation of n.c.a. 2-[18F]F-A85380 for human use.
abstract: 2-[18F]F-A85380 is the first subtype selective PET-radiotracer to visualize the distribution of alpha4beta2 nicotinic acetylcholine receptors in human brain in vivo. We investigated a fast and safe automated production of 2-[18F]F-A85380 by purification of the BOC-protected intermediate product with a combination of solid phase extraction cartridges. After deprotection, adjustment of the pH and sterile filtration n.c.a. 2-[18F]F-A85380 was applicable for the use in human studies with a high specific activity and an overall radiochemical yield of 55% in 35 minutes.
authors: Department of Nuclear Medicine, University of Bonn, Germany. joern.schmaljohann@ukb.uni-bonn.de
authors: J
authors: J
authors: Schmaljohann
authors: D
authors: D
authors: Gündisch
authors: M
authors: M
authors: Minnerop
authors: A
authors: A
authors: Joe
authors: J
authors: J
authors: Bucerius
authors: C
authors: C
authors: Dittmar
authors: F
authors: F
authors: Jessen
authors: S
authors: S
authors: Guhlke
authors: U
authors: U
authors: Wüllner
mesh_terms: D001384:Azetidines / Q000138:chemical synthesis*; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D049268:Positron-Emission Tomography; D011725:Pyridines / Q000138:chemical synthesis*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D011978:Receptors, Nicotinic / Q000378:metabolism
chemical_list: C119803:2-fluoro-3-(2-azetidinylmethoxy)pyridine; D001384:Azetidines; D011725:Pyridines; D019275:Radiopharmaceuticals; D011978:Receptors, Nicotinic; C403531:nicotinic receptor alpha4beta2