title: Centripetal lens epithelial cell migration: a prospective study of the Alcon SA60AT intraocular lens.
abstract: OBJECTIVE
  To evaluate prospectively the incidence and severity of centripetal lens epithelial cell migration (CLECM) onto the anterior surface of the Alcon SA60AT intraocular lens (IOL).
  
  
  METHODS
  One hundred and four consecutive cases of SA60AT IOL implantations were prospectively evaluated. At the 1-month postoperative visit, best corrected visual acuity (BCVA) was obtained. Following maximal pupillary dilatation, the extent of CLECM was assessed using a simplified grading scale (0-4). The centrality of the lens within the capsular bag was recorded. Patients with the highest grade of CLECM were recalled for reassessment at a minimum of 3 months.
  
  
  RESULTS
  Centripetal lens epithelial cell migration data were obtained on 99 patients. Of these, 94% demonstrated CLECM of varying severity at 1 month postoperatively. The severity was low grade in 54% of patients (29% grade 1, 24% grade 2), and high grade in 40% of patients (16% grade 3, 24% grade 4). BCVA results were good (91.9% 6/6 or better) and did not correlate with CLECM grade. Operative capsulorhexis size did not correlate with the severity of CLECM. The lens was well-centred in 91 of 92 patients in whom lens position was assessed. Twenty-three patients with grade 4 CLECM at 1 month were brought back for reassessment (3.5-13 months postoperatively) and 18 of these demonstrated complete regression of CLECM (to grade 0).
  
  
  CONCLUSIONS
  There is a high incidence and severity of CLECM 1 month postoperatively using the Alcon SA60AT IOL. There was no significant correlation between CLECM grade and either BCVA at 1 month, capsulorhexis size or lens centration. CLECM appears to be a frequent, benign and transient event with this lens.
authors: Ophthalmic Surgery Centre, Sydney, New South Wales, Australia.
authors: Nagi N
authors: NN
authors: Assaad
authors: Leanne M
authors: LM
authors: Cheung
authors: Charmaine
authors: C
authors: Lim
authors: Ian C
authors: IC
authors: Francis
authors: Minas T
authors: MT
authors: Coroneo
authors: Stella L
authors: SL
authors: Alexander
authors: R Steve
authors: RS
authors: Schumacher
mesh_terms: D000180:Acrylic Resins; D019923:Capsulorhexis; D002386:Cataract / Q000473:pathology; D002465:Cell Movement; D004847:Epithelial Cells / Q000473:pathology*; D006801:Humans; D019654:Lens Implantation, Intraocular; D007908:Lens, Crystalline / Q000473:pathology*; D007910:Lenses, Intraocular; D018918:Phacoemulsification; D011183:Postoperative Complications; D011446:Prospective Studies; D014792:Visual Acuity
chemical_list: D000180:Acrylic Resins