Prevalence of allergic fungal sinusitis in refractory chronic rhinosinusitis in adult Malaysians.
OBJECTIVE
To determine the prevalence of allergic fungal sinusitis (AFS) in refractory chronic rhinosinusitis (CRS) in adult Malaysians.


METHODS
This cross-sectional study involved 30 immunocompetent CRS patients who underwent surgery. Specimens were sent for mycology and histopathologic analysis for identification of fungi. Clinical and immunological workup was performed for atopy in all patients and controls.


RESULTS
Fungal cultures were positive in 5 (16.7%) and 11 (36.7%) of 30 patients from nasal secretions and surgical specimens, respectively. Allergic mucin was found in 8 surgical specimens (26.7%). Hence, prevalence of AFS was 26.7%. The most common causative agent was Aspergillus sp. (54.5%). In 3 (37.5%) of 8 patients, AFS was found to be associated with asthma. Twenty-five percent (2/8 patients) had aspirin intolerance, and 62.5% (5/8 patients) had elevated total immunoglobulin E levels. All patients had positive skin test reactivity to fungal allergen.


CONCLUSIONS
This preliminary study suggests that AFS does exist in Malaysia. Proper handling of surgical specimens and accurate diagnosis by the pathologist and mycologist are essential.
Goh
Bee-See
BS
Department of Otorhinolaryngology, Faculty of Medicine, National University of Malaysia, Kuala Lumpur.
Gendeh
Balwant Singh
BS
Rose
Isa Mohamed
IM
Pit
Sabiha
S
Samad
Shamim Abdul
SA
D000328:Adult; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D006801:Humans; D008296:Malaysia / Q000453:epidemiology; D009181:Mycoses / Q000150:complications*; D009296:Nasal Cavity; D015995:Prevalence; D012130:Respiratory Hypersensitivity / Q000453:epidemiology* / Q000382:microbiology* / Q000473:pathology; D012220:Rhinitis / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology; D012852:Sinusitis / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology; D007507:Therapeutic Irrigation