Myxofibrosarcoma (myxoid malignant fibrous histiocytoma) showing cutaneous presentation: report of two cases.
Myxofibrosarcoma or myxoid malignant fibrous histiocytoma is one of the most common fibroblastic sarcomas in older patients. It is characterized by a tendency for predominantly subcutaneous, multinodular, diffusely infiltrative growth, which may extend to the overlying dermis and present as a cutaneous lesion. Histologically, it comprises a spectrum ranging from hypocellular low-grade myxoid to high-grade pleomorphic sarcoma. Because the dermal presentation usually appears relatively banal, accurate diagnosis is sometimes challenging. In this report, we present two cases of myxofibrosarcoma with dermal involvement.
Fujimura
Taku
T
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan. fujimura@gonryo.med.tohoku.ac.jp
Okuyama
Ryuhei
R
Terui
Tadashi
T
Okuno
Kousei
K
Masu
Akiko
A
Masu
Takashi
T
Chiba
Shuko
S
Kunii
Takahide
T
Tagami
Hachiro
H
Aiba
Setsuya
S
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D018572:Disease-Free Survival; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D009077:Mucins / Q000032:analysis; D018714:Radiotherapy, Adjuvant; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D012983:Soft Tissue Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D016896:Treatment Outcome
D014408:Biomarkers, Tumor; D009077:Mucins