title: [Expressions of FHIT and cyclin D1/CDK4 in oral cancer and oral precancerous lesions].
abstract: OBJECTIVE
  To detect the expressions of fragile histidine triad (FHIT) and cyclin D1/CDK4 in oral squamous cell carcinoma (OSCC) and oral precancerous lesions and investigate the relationship between the expressions and the histopathological changes.
  
  
  METHODS
  Immunohistochemical staining by SP methods was utilized to detect the expression of FHIT and cyclin D1/CDK4 in 64 cases of OSCC, 39 oral precancerous lesions and 12 normal oral mucosa specimens.
  
  
  RESULTS
  The rate of the negative or low FHIT expression in OSCC was 17% (11/64), which was remarkably lower than that in normal oral membrane and oral precancerous lesions (P<0.01). Significantly higher levels of cyclin D1/CDK4 expressed in OSCC than in normal oral membrane and precancerous lesions (P<0.01). There was no significant correlation between FHIT and cyclin D1/CDK4, and positive correlation between cyclin D1 and CDK4 was observed.
  
  
  CONCLUSIONS
  FHIT, cyclin D1 and CDK4 may play a role in the pathogenesis of OSCC, and FHIT can down-regulate the expression of cyclin D1.
authors: Guangdong Provincial Stomatological Hospital, Guangzhou 510280, China. yin9731@hotmail.com
authors: Cao
authors: C
authors: Yin
authors: Li-jia
authors: LJ
authors: Shen
authors: Si-ming
authors: SM
authors: Xie
authors: Ping
authors: P
authors: Ruan
authors: Xi
authors: X
authors: Yao
mesh_terms: D017766:Acid Anhydride Hydrolases / Q000096:biosynthesis*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology; D019938:Cyclin D1 / Q000096:biosynthesis*; D051358:Cyclin-Dependent Kinase 4 / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008297:Male; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D011230:Precancerous Conditions / Q000378:metabolism / Q000473:pathology*; D000099170:Bis(5'-adenosyl)triphosphatase
chemical_list: D017766:Acid Anhydride Hydrolases; D019938:Cyclin D1; D051358:Cyclin-Dependent Kinase 4; D009363:Neoplasm Proteins; D000099170:Bis(5'-adenosyl)triphosphatase