title: Differences between attention-deficit disorder with and without hyperactivity: a 1H-magnetic resonance spectroscopy study.
abstract: Using proton magnetic resonance spectroscopy ((1)H-MRS) to investigate possible neurometabolic differences between the predominantly inattentive subtype (ADHD-I), the combined subtype (ADHD-C) and normal controls. Proton spectra were acquired bilaterally on the lenticular nucleus in 20 schoolboys having ADHD and 10 matched controls. The boys with ADHD were divided into ADHD-C subtype (n=10) and ADHD-I subtype (n=10) according to DSM-IV criteria. The peaks of N-acetylaspartate (NAA), Choline moieties (Cho), myo-inositol (mI), creatine (Cr) and alpha-Glx were measured and their ratios to Cr were calculated. One-way ANOVA and post-hoc Bonferroni tests were used to detect the difference of the peak-area ratios of NAA, Cho, mI, and alpha-Glx to Cr among the three groups. There was a significant overall group difference in the NAA/Cr ratio both in the right and left lenticular nucleus (right: P=0.002; left: P=0.003). Only the ADHD-C subtype group showed a significant difference with controls (right: P=0.001; left: P=0.003) the right lenticular nucleus, the NAA/Cr ratio in the ADHD-C group was significantly lower than that in the ADHD-I group (P=0.012). In the left lenticular nucleus, the NAA/Cr ratio in the ADHD-C group showed a significant trend compared to the ADHD-I group (P=0.06). This study demonstrated the existence of measurable difference between children with ADHD-C and ADHD-I using (1)H-MRS.
authors: Insttitute of Mental Health, Peking University, Huayuanbeilu 51, Haidian District, Beijing 100083, People's Republic of China.
authors: Li
authors: L
authors: Sun
authors: Zhen
authors: Z
authors: Jin
authors: Yu-feng
authors: YF
authors: Zang
authors: Ya-Wei
authors: YW
authors: Zeng
authors: Gang
authors: G
authors: Liu
authors: Yang
authors: Y
authors: Li
authors: Larry J
authors: LJ
authors: Seidman
authors: Stephen V
authors: SV
authors: Faraone
authors: Yu-feng
authors: YF
authors: Wang
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis*; D001921:Brain / Q000503:physiopathology*; D002648:Child; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male