Effect of chronic administration of chlorpromazine on electrical parameters of command neurons in edible snail.
Electrophysiological experiments showed that chronic administration of neuroleptic chlorpromazine depolarized plasma membrane and decreased the threshold of action potential generation in command neuron of defense behavior of edible snail and motoneurons of pneumostome closure reflex. The effects of chlorpromazine on electrical parameters of the identified neurons can be explained by its serotonin-depleting action.
Gainutdinova
T Kh
TKh
Kazan Physicotechnical Institute, Kazan Research Center, Russian Academy of Sciences. gainutdinov@mail.knc.ru
Meshchaninova
A V
AV
Andrianov
V V
VV
Silant'eva
D I
DI
Gainutdinov
Kh L
KhL
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology*; D004594:Electrophysiology; D006372:Helix, Snails / Q000502:physiology*; D008839:Microelectrodes; D009474:Neurons / Q000187:drug effects / Q000502:physiology*
D014150:Antipsychotic Agents; D002746:Chlorpromazine