Cystic fibrosis modifier genes.
Since the recognition that CFTR genotype was not a good predictor of pulmonary disease severity in CF, several candidate modifier genes have been identified. It is unlikely that a single modifier gene will be found, but more probable that several haplotypes in combination may contribute, which in itself presents a major methodological challenge. The aims of such studies are to increase our understanding of disease pathogenesis, to aid prognosis and ultimately to lead to the development of novel treatments.
Davies
Jane
J
Department of Gene Therapy, Faculty of Medicine, Imperial College, Emmanuel Kaye Building, Manresa Road, London, UK. j.c.davies@imperial.ac.uk
Alton
Eric
E
Griesenbach
Uta
U
D001424:Bacterial Infections / Q000150:complications / Q000235:genetics / Q000276:immunology; D003550:Cystic Fibrosis / Q000150:complications / Q000235:genetics* / Q000276:immunology; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics*; D005767:Gastrointestinal Diseases / Q000209:etiology / Q000235:genetics / Q000276:immunology; D006239:Haplotypes; D006801:Humans; D008107:Liver Diseases / Q000209:etiology / Q000235:genetics / Q000276:immunology; D010641:Phenotype; D011110:Polymorphism, Genetic; D012106:Research
C505032:CFTR protein, human; D019005:Cystic Fibrosis Transmembrane Conductance Regulator