[Psoriasis SCID-mouse model].
Psoriasis is characterized by a complex phenotype and pathogenesis along with polygenic determination. Several psoriasis animal models have only been able to incompletely reproduce the disease. A xenogeneic transplantation approach, grafting skin from psoriatic patients onto mice with a severe combined immunodeficiency (SCID), was the first to meet the criteria for a psoriasis model. During the last 10 years, this psoriasis SCID-mouse model not only allowed telling experiments focusing on pathogenetic aspects, but also proved being a powerful tool for drug discovery with a good predictive value.
Pfeffer
J
J
Zentrum der Dermatologie und Venerologie, Johann Wolfgang Goethe-Universität, Frankfurt am Main.
Kaufmann
R
R
Boehncke
W-H
WH
D000818:Animals; D003879:Dermatologic Agents / Q000627:therapeutic use; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D016513:Mice, SCID; D010641:Phenotype; D011565:Psoriasis / Q000188:drug therapy / Q000209:etiology / Q000235:genetics / Q000276:immunology / Q000473:pathology; D016511:Severe Combined Immunodeficiency; D012867:Skin / Q000473:pathology; D016038:Skin Transplantation; D014183:Transplantation, Heterologous
D003879:Dermatologic Agents