[Myoepithelioma of soft tissue -- case report with clinicopathologic, ultrastructural, and cytogenetic findings].
The case of a soft tissue myoepithelioma is presented including clinicopathologic, ultrastructural, and genetic findings. A 30-year-old male patient suffered from a soft tissue tumor within the deep soft tissues of the right lower leg measuring 13.2 x 8.2 x 9 cm. Histologically, the lesion was diagnosed as a myoepithelioma displaying a lobulated architecture with cords and nests of epithelioid and spindle cells without cytologic atypia lying within a fibromyxoid and partly chondroid matrix; immunohistochemistry was positive for pancytokeratin, S100-protein, calponin and partly for GFAP and EMA. Ultrastructural analysis revealed glycogen deposits and cell-membrane-associated plaque structures, whereas true myofilaments could not be identified (with immunohistochemistry being negative for actin). Using comparative genomic hybridization (CGH), a gain of chromosome Y was detected. A loss on 17p could not be detected unambiguously. However, based on the low resolution of CGH a small loss cannot be excluded. The patient was free of disease 25 months following complete tumor resection. Myoepitheliomas/mixed tumors of deep soft tissue represent rare soft tissue lesions that may reach a considerable size and may mimic other soft tissue tumors or sarcomas. Based on a local relapse rate of approximately 20% according to the literature, a complete resection with thorough follow-up should be recommended.
Kuhnen
C
C
Institut für Pathologie der Ruhr-Universität Bochum an den Berufsgenossenschaftlichen Kliniken Bergmannsheil. Cornelius.Kuhnen@ruhr-uni-bochum.de
Herter
P
P
Kasprzynski
A
A
Vogt
M
M
Jaworska
M
M
Johnen
G
G
D000328:Adult; D002135:Calcium-Binding Proteins / Q000378:metabolism; D004273:DNA, Neoplasm / Q000378:metabolism; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007866:Leg; D008297:Male; D008840:Microfilament Proteins; D009208:Myoepithelioma / Q000235:genetics / Q000473:pathology* / Q000648:ultrastructure; D009693:Nucleic Acid Hybridization; D009418:S100 Proteins / Q000378:metabolism; D012983:Soft Tissue Neoplasms / Q000235:genetics / Q000473:pathology* / Q000648:ultrastructure; D000096985:Calponins
D002135:Calcium-Binding Proteins; D004273:DNA, Neoplasm; D005904:Glial Fibrillary Acidic Protein; D008840:Microfilament Proteins; D009418:S100 Proteins; D000096985:Calponins