PSA course after definitive high-dose radiotherapy of localized prostate cancer.
OBJECTIVE
After radical prostatectomy, PSA levels that reach near zero values in less than 14 days are associated with a favourable prognosis. The aim of this analysis was to investigate whether PSA also declines to near zero values after combined tele-brachytherapy.


METHODS
Forty-one patient, treated with combined tele-brachytherapy for prostate cancer, were followed for at least 2 years after treatment with repeated PSA measurements.


RESULTS
PSA values <1.0 ng/ml were only reached after 15 months; near zero PSA levels were not reached until 18-24 months after treatment (median: 0.25 ng/ml).


CONCLUSIONS
A PSA decline to near zero values occurs after definitive tele-brachytherapy, but it takes longer than after surgery (18-24 months).
Schüller
Patrick
P
Klinik und Poliklinik für Strahlentherapie--Radioonkologie, Universitätsklinikum Münster, Germany. pschuel@uni-muenster.de
Schäfer
Ulrich
U
Micke
Oliver
O
Panke
Joan E
JE
Willich
Normann
N
D000368:Aged; D001918:Brachytherapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000532:radiotherapy*; D011879:Radiotherapy Dosage
D017430:Prostate-Specific Antigen