title: Quantitative electroencephalogram analysis in dementia with Lewy bodies and Alzheimer's disease.
abstract: Clinicopathophysiological differences between dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) remain obscure. Our goals were to determine whether characteristic findings of electroencephalogram (EEG) power and coherence in DLB and a differential pathophysiological mechanism of quantitative EEG existed between DLB and AD. The group consisted of 15 patients with AD or DLB and 12 age-matched controls. Original EEG signals were recorded from 14 scalp electrodes positioned according to the International 10-20 System, using digitally linked earlobes as a reference. Although EEG power spectral analysis showed increasing EEG power density in patients with DLB in the delta and theta bands, such a difference did not exist in patients with AD. Compared with AD, the delta and theta band intrahemispheric coherence values in the fronto-temporo-central regions were higher in DLB. In the beta band, AD was lower than DLB in almost all temporo-centro-parieto-occipital regions. Comparing the mean power value between patients with/without donepezil treatment, there was a significantly lower EEG power density in the delta and theta bands in DLB subjects taking donepezil than in subjects not taking donepezil, whereas there was no significant difference in AD patients. These results suggest that cholinergic dysfunction is stronger in DLB than AD.
authors: Division of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, 36-1 Nishimachi, Yonago 683-8504, Japan.
authors: Toru
authors: T
authors: Kai
authors: Yasumasa
authors: Y
authors: Asai
authors: Kenji
authors: K
authors: Sakuma
authors: Tatsuya
authors: T
authors: Koeda
authors: Kenji
authors: K
authors: Nakashima
mesh_terms: D000368:Aged; D000465:Algorithms; D000544:Alzheimer Disease / Q000188:drug therapy / Q000503:physiopathology*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D000077265:Donepezil; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007189:Indans / Q000627:therapeutic use; D020961:Lewy Body Disease / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D010880:Piperidines / Q000627:therapeutic use
chemical_list: D002800:Cholinesterase Inhibitors; D007189:Indans; D010880:Piperidines; D000077265:Donepezil