Enhanced learning of normal adult rodents by repeated oral administration of soybean transphosphatidylated phosphatidylserine.
Soybean lecithin transphosphatidylated phosphatidylserine (SB-tPS) is already known to improve the learning ability of aged or drug-induced amnesic rodents. In this study, its effect on normal adult rodents was evaluated using several learning tasks. Firstly, three behavioral tests (open-field, Y-maze, and active avoidance test) were consecutively carried out after the daily oral administration of SB-tPS (50 mg/kg per day, for 34 days). Repeated oral administration of SB-tPS did not affect either exploratory behavior in the open-field test or spontaneous alternation behavior in the Y-maze test, while mice pretreated with SB-tPS showed significant enhancement of conditioned avoidance response. Secondly, the brightness discrimination test was used to evaluate the effect of SB-tPS on learning ability. The daily oral administration of SB-tPS (50 mg/kg per day, for 27 days) to normal rats significantly increased the correct response ratio in the brightness discrimination test. Finally, to elucidate the necessity of SB-tPS pretreatment, another active avoidance test was carried out, and no enhancement of conditioned avoidance response was observed in non-pretreated mice. These results suggest that repeated administration of SB-tPS could enhance the learning ability of normal adult rodents as those of aged ones.
Kataoka-Kato
Akito
A
Yakult Central Institute for Microbiological Research, Tokyo, Japan. akito-kataoka@yakult.co.jp
Ukai
Makoto
M
Sakai
Masashi
M
Kudo
Satoshi
S
Kameyama
Tsutomu
T
D000109:Acetylcholine / Q000378:metabolism; D000284:Administration, Oral; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D004193:Discrimination Learning / Q000187:drug effects; D007858:Learning / Q000187:drug effects*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D010718:Phosphatidylserines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D013025:Glycine max / Q000737:chemistry
D010718:Phosphatidylserines; D000109:Acetylcholine