[Effect of intensive insulin therapy on serum proinflammatory cytokine levels in patients with severe trauma].
OBJECTIVE
To investigate the effect of intensive insulin therapy on serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and C reaction protein (CRP), all of which reflected the inflammatory status in patients with severe trauma.


METHODS
Forty patients with severe trauma [injury severity score (ISS)>or=20] were randomly divided into intensive insulin therapy group and control group. Enzyme-linked immunoadsorbent assay (ELISA) method was used to determine the TNF-alpha and IL-6 levels within 72 hours after admission.


RESULTS
Serum levels of TNF-alpha, IL-6 and CRP in patients received intensive insulin therapy were significantly lower than those in patients without the therapy (P<0.05 or P<0.01).


CONCLUSIONS
Intensive insulin therapy can attenuate the systemic inflammatory response to trauma. The anti-inflammatory actions of insulin, as well as its glycemia controlling effects, might contribute to the improved outcomes of patients with severe trauma.
Zhao
Xiao-dong
XD
Emergency Department, 304th Hospital Affiliated to General Hospital of PLA, Beijing 100037, China.
Meng
Hai-dong
HD
Yao
Yong-ming
YM
Yan
Run-min
RM
Deng
Qun
Q
He
Zhong-jie
ZJ
Peng
Guo-qiu
GQ
Yan
Bai-gang
BG
Liang
Hua-ping
HP
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D014947:Wounds and Injuries / Q000097:blood / Q000188:drug therapy*
D000893:Anti-Inflammatory Agents; D007328:Insulin; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein