title: Consecutive organ transplantation in inbred rats: long-term results--Are organs recyclable?
abstract: Using 9-12-month-old Lewis rats, our laboratory performed consecutive organ transplantations to assess the technical feasibility and observe the histopathologies of prolonged transplants and implants over a rat's life span. This study includes a total of 688 cases of consecutive syngeneic organ transplantation, including pancreaticoduodenum (PD), en-bloc liver-pancreaticoduodenum-spleen-stomach (LPdSpSt), and spleen bearing ovary or testicle. A 52-month-old consecutively transplanted pancreas showed normal acini and islet cells. Consecutively transplanted LPdSpSt cases at 25-28 months preserved normal histology. After 26.5 months of ovarian follicle implantation into the spleen, the pathology of the organ exhibited typical dysgerminoma. However, 29.5-month-old infantile testicle implants in the spleen showed seminoma. Our studies suggest that transplanted organs can be reusable and retransplanted, and we hope this could be one of the clues to solve donor-organ shortages in the future.
authors: San Diego Microsurgical Institute, Scripps Mercy Hospital, San Diego, CA 92103, USA. msurgical@yahoo.com
authors: Sun
authors: S
authors: Lee
authors: In C
authors: IC
authors: Hong
authors: Chang H
authors: CH
authors: Yoo
authors: Sam
authors: S
authors: Nam
authors: Sammy
authors: S
authors: Bai
authors: Christopher
authors: C
authors: Pivetti
authors: Kenny K
authors: KK
authors: Kim
authors: Greg
authors: G
authors: Emmanuel
authors: Jason J
authors: JJ
authors: Kim
authors: Milbhor
authors: M
authors: D'Silva
authors: Yuquin
authors: Y
authors: Wang
authors: Masumi
authors: M
authors: Nozawa
authors: Donna
authors: D
authors: Lee
authors: S
authors: S
authors: Niewiadomski
authors: Jin H
authors: JH
authors: Yoon
authors: Se I
authors: SI
authors: Jung
authors: Paul
authors: P
authors: Wolf
authors: Ruben F
authors: RF
authors: Gittes
mesh_terms: D000818:Animals; D016377:Organ Transplantation / Q000379:methods* / Q000502:physiology; D051381:Rats; D011917:Rats, Inbred Lew; D012086:Reoperation; D014019:Tissue Donors / Q000600:supply & distribution*