The molecular basis of idiopathic short stature.
Forty years ago, when growth hormone (GH) first became available for use, the molecular basis for growth hormone deficiency (GHD) was entirely unknown. Despite continued difficulties with the biochemical diagnosis of GHD, we now accept the existence of underlying genetic abnormalities as the basis for disorders involving GH secretion. Similar challenges are encountered when one considers the causes of non-GHD short stature, namely idiopathic short stature (ISS). Categorization of the causes for ISS by insulin-like growth factor I (IGF-I) concentrations provides a basis for speculation about the potential for IGF-I gene polymorphisms or binding protein abnormalities influencing the development of ISS-related growth failure.
Rosenfeld
Ron G
RG
Lucile Packard Foundation for Children's Health, 770 Welch Road, Suite 350, Palo Alto, CA 94022, USA. ron.rosenfeld@lpfch.org
D006130:Growth Disorders / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D019382:Human Growth Hormone / Q000172:deficiency / Q000235:genetics / Q000627:therapeutic use; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism
D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I