[Pathogenic basis of treatment in children with bronchial asthma and gastroesophageal reflux].
The relationship between bronchial asthma (BA) and gastro-esophageal reflux (GER) impose to study by frequency, reciprocally prognosis and therapeutics difficulty. Coexistence of both diseases is suggested by presence of asthmatics symptoms in non-atopic patients, difficult control and resistance of the specific treatment of asthma disease, worsening of respiratory symptoms in circumstances which favored GER. Pathogenetic relationship between BA and GER in children is the result of the associations- digestive particularity and: esophago-bronchial neurogenic mechanism produced by micro-aspiration , genetic or obtained inflammations development by commune Th2 mediators, medications effects. Classical treatments (H2-inhibitors, prokinetics agents, inhibitors of protonic pumps) is associated of the antiasthmatics "controller" therapy and in the future, anti-cytokine and anti-receptor therapy.
Gotia
Stela
S
Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi Facultatea de Medicină, Clinica a II-a Pediatrie.
Murgu
Alina
A
Burlacu
M
M
D001249:Asthma / Q000150:complications / Q000503:physiopathology* / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D018680:Cholinergic Antagonists / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D018662:Fundoplication; D018755:GABA Agonists / Q000627:therapeutic use; D005764:Gastroesophageal Reflux / Q000150:complications / Q000503:physiopathology* / Q000628:therapy*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use
D018680:Cholinergic Antagonists; D004791:Enzyme Inhibitors; D018755:GABA Agonists; D006635:Histamine H2 Antagonists; D017366:Serotonin Receptor Agonists