title: Exposure to chronic noise and fractionated X-ray radiation elicits biochemical changes and disrupts body weight gain in rat.
abstract: The aim was to assess the developmental and biochemical effects resulting from separate and combined exposures to radiation and noise in adult male Sprague-Dawley rats. For 21 days, animals were exposed daily (1) to whole-body 121 kVp X-ray exposure (cumulative dose=5 Gy), (2) to random intermittent noise band-limited between 0.4 and 20 kHz; 2 h day(-1) 86 decibels (dB) and (3) to combined exposures. Control animals were housed under ambient noise conditions 55 dB A-weighted (dBA) and sham-exposed to X-rays. Body weight gain was significantly reduced in animals exposed to either X-rays or noise, and the loss was more pronounced in animals exposed to both conditions. Neither plasma adrenocorticotropic hormone (ACTH) nor corticosterone was altered by the treatment conditions. This study corroborated previous reports that ionizing radiation exposure increased plasma levels of 8-hydroxy-2'-deoxyguanosine (8-OHDG), but no effect was observed in animals co-exposed to chronic noise. Plasma big-endothelin-1 (Big ET-1) was significantly reduced in animals exposed to a combination of noise and X-rays. The results indicated that (1) adaptation to chronic noise appeared to occur at the level of the hypothalamic pituitary adrenal (HPA) response, in spite of a compromise in overall body weight gain; and (2) ionizing radiation exposure might alter systems activated by stressor exposure and/or act independently to influence health outcomes.
authors: Consumer and Clinical Radiation Protection Bureau, Health Canada, Ottawa, Canada. dmichaud@hc-sc.gc.ca
authors: Ds
authors: D
authors: Michaud
authors: Sm
authors: S
authors: Miller
authors: C
authors: C
authors: Ferrarotto
authors: Se
authors: S
authors: Keith
authors: Wj
authors: W
authors: Bowers
authors: P
authors: P
authors: Kumarathsan
authors: L
authors: L
authors: Marro
authors: A
authors: A
authors: Trivedi
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000311:Adrenal Glands / Q000528:radiation effects; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D003345:Corticosterone / Q000097:blood; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000097:blood; D019332:Endothelin-1 / Q000097:blood; D008297:Male; D009622:Noise / Q000009:adverse effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015430:Weight Gain / Q000528:radiation effects*; D014965:X-Rays
chemical_list: D019332:Endothelin-1; D000080242:8-Hydroxy-2'-Deoxyguanosine; D000324:Adrenocorticotropic Hormone; D003849:Deoxyguanosine; D003345:Corticosterone