title: Intraindividual comparison of 1.0 M gadobutrol and 0.5 M gadopentetate dimeglumine for time-resolved contrast-enhanced three-dimensional magnetic resonance angiography of the upper torso.
abstract: OBJECTIVE
  To compare the signal characteristics and bolus dynamics of 1.0 M gadobutrol and 0.5 M Gd-DTPA for time-resolved, three-dimensional, contrast-enhanced (CE) MRA of the upper torso.
  
  
  METHODS
  Ten healthy volunteers were examined with time-resolved three-dimensional CE-MRA (scan time per three-dimensional data set: 0.86 second; voxel size: 3.6 x 2 x 6.3 mm(3)). Each volunteer underwent eight individual examinations after intravenous injection of 0.05 and 0.1 mmol/kg body weight (b.w.) of 1.0 M gadobutrol and 0.5 M Gd-DTPA using two injection rates (2.5 and 5 mL/second). The data analysis included quantitative measurements of the peak signal-to-noise ratio (SNR) and bolus dispersion (full width at half maximum (FWHM)) in the pulmonary artery, left atrium, and thoracic and abdominal aortas.
  
  
  RESULTS
  No significant differences in the peak SNR and bolus dispersion were observed between gadobutrol and Gd-DTPA for all dose levels and injection rates in any of the vascular segments. For both contrast agents a dose of 0.1 mmol/kg b.w. injected with 5 mL/second achieved the highest SNR in all vascular segments.
  
  
  CONCLUSIONS
  For the imaging parameters used in this study, higher-concentrated gadolinium chelates offer no relevant advantages for time-resolved three-dimensional CE-MRA of the upper torso.
authors: Department of Radiology, German Cancer Research Center, Heidelberg, Germany. christian.fink@med.uni-muenchen.de
authors: Christian
authors: C
authors: Fink
authors: Michael
authors: M
authors: Puderbach
authors: Sebastian
authors: S
authors: Ley
authors: Frank
authors: F
authors: Risse
authors: Tristan A
authors: TA
authors: Kuder
authors: M
authors: M
authors: Bock
authors: Julian
authors: J
authors: Thaler
authors: Christian
authors: C
authors: Plathow
authors: Hans-Ulrich
authors: HU
authors: Kauczor
mesh_terms: D015992:Body Mass Index; D015331:Cohort Studies; D003287:Contrast Media; D004305:Dose-Response Relationship, Drug; D005260:Female; D019786:Gadolinium DTPA / Q000494:pharmacology*; D006801:Humans; D021621:Imaging, Three-Dimensional; D007275:Injections, Intravenous; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D009942:Organometallic Compounds / Q000494:pharmacology*; D011856:Radiographic Image Enhancement; D012016:Reference Values; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D013909:Thorax / Q000098:blood supply* / Q000473:pathology
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C090600:gadobutrol; D019786:Gadolinium DTPA