Multiple disseminated large-cell acanthomas of the skin associated with human papillomavirus type 6.
Cutaneous acanthomas encompass many clinically distinct types. We describe a patient with multiple nodules on the skin of the upper limbs which were histologically diagnosed as large-cell acanthomas. Further analysis revealed, surprisingly, the presence of human papillomavirus (HPV) type 6 within these lesions. HPV type 6 should therefore be considered an important cofactor in the pathogenesis of large-cell acanthomas.
Berger
Thomas
T
Departments of Dermatology, University of Erlangen-Nuremberg, Erlangen, Germany. bergerts@web.de
Stockfleth
Eggert
E
Meyer
Thomas
T
Kiesewetter
Franklin
F
Funk
Jens Oliver
JO
D049309:Acanthoma / Q000473:pathology / Q000821:virology*; D052163:Human papillomavirus 6 / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000473:pathology / Q000821:virology*