[Antagonistic effects of selenium on the expression of c-fos in central nerval system of rat included by mercury contaminated rice].
The objective of this paper is to study the antagonisms between selenium and mercury and the effect of different species mercury on the brain injury. The expression of c-fos mRNA and c-FOS protein in rat brain induced by Hg-contaminated rice was observed by using reverse transcriptions polymerase chain reaction (RT-PCR) and immunocytochemical methods. The results show the Hg-contaminated rice induced significantly the expression of c-fos mRNA and c-FOS protein; selenium could antagonize mercury accumulative level in brain. Antagonistic effects of selenium on the expression of c-fos included by mercury and the molecule mechanism of the antagonisms between selenium and mercury was probed, too.
Cheng
Jin-ping
JP
School of Environmental Science and Engineering, Shanghai Jiaotong University, Shanghai 200240, China.
Wang
Wen-hua
WH
Jia
Jin-ping
JP
Qu
Li-ya
LY
Zheng
Min
M
Shen
Zhe-ming
ZM
Shi
Wei
W
D000818:Animals; D001921:Brain / Q000378:metabolism*; D005506:Food Contamination; D008628:Mercury / Q000032:analysis / Q000037:antagonists & inhibitors*; D012275:Oryza; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D012643:Selenium / Q000494:pharmacology*
D016760:Proto-Oncogene Proteins c-fos; D012333:RNA, Messenger; D008628:Mercury; D012643:Selenium