Novel HLA-A*31 allele, A*3111 identified by sequence-based typing.
In this report, we describe the identification of an HLA-A*31 nucleotide sequence variant, a new HLA-A*3111, in three members of a Korean family by using sequence-based typing (SBT). The new allele was detected during routine HLA typing by high-resolution SBT. Allele A*3111 showed one nucleotide difference with A*310102 at codon 165 (GTG-->CTG) resulting in an amino acid change from valine to leucine (V165L). Serologic reactivity was shorter than normally expected.
Hwang
S-H
SH
Department of Laboratory Medicine, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Oh
H-B
HB
Hur
S-S
SS
Lee
M-N
MN
Hong
S-A
SA
Kwon
O-J
OJ
D000483:Alleles; D044466:Asian People / Q000235:genetics; D001483:Base Sequence; D003062:Codon / Q000235:genetics; D015234:HLA-A Antigens / Q000235:genetics* / Q000276:immunology*; D006650:Histocompatibility Testing / Q000379:methods; D006801:Humans; D007723:Korea / Q000208:ethnology; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D016415:Sequence Alignment
D003062:Codon; D015234:HLA-A Antigens