[Preparation of 8-chloro-adenosine long circulation liposomes and its pharmacokinetics in rats].
OBJECTIVE
To prepare 8-chloro-adenosine (8-Cl-A) long circulation liposomes with high entrapped efficiency and prolonged action-time of 8-Cl-A in vivo.


METHODS
To prepare 8-Cl-A long circulation liposomes of nanometer size by improved multiple emulsion. The entrapped efficiency, size and size distribution of 8-Cl-A long circulation liposomes were determined, and its pharmacokinetics in rats was evaluated.


RESULTS
The entrapped efficiency of 8-Cl-A long circulation liposomes was 62.70% and mean diameter of the liposomes was 79.9 nm. The pharmacokinetics studies indicated that 8-Cl-A long circulation liposomes showed higher drug concentration and larger AUC values than that of 8-Cl-A after iv to rats.


CONCLUSIONS
8-Cl-A long circulation liposomes could prolong the action-time of 8-Cl-A in vivo.
Yang
Li
L
Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China.
Qi
Xian-rong
XR
Shi
Jing
J
Chen
Wen-qian
WQ
Zhang
Qiang
Q
D015762:2-Chloroadenosine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D019540:Area Under Curve; D003692:Delayed-Action Preparations; D008081:Liposomes; D008297:Male; D049329:Nanostructures; D010316:Particle Size; D051381:Rats; D017208:Rats, Wistar
D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D008081:Liposomes; D015762:2-Chloroadenosine; C075440:8-chloroadenosine