Carbimazole induced eosinophilic granulomatous vasculitis localized to the stomach.
Vasculitis associated with anti-neutrophil cytoplasmic antibodies has been reported in patients treated with anti-thyroid drugs and especially propylthiouracil. We report here a case of granulomatous eosinophilic vasculitis mimicking gastric neoplasm and peripheral eosinophilia in a 27-year-old man who was treated with carbimazole for 5 months for Graves' disease. Clinical and morphologic features resolved within 2 months after stopping the drug, suggesting a causative role for the drug. To our knowledge, this is the first biopsy-proven granulomatous eosinophilic vasculitis associated with this drug.
Sève
P
P
Department of Internal Medicine, Hôtel Dieu, 1 place de l'Hôpital, Lyon Cedex 02, France.
Stankovic
K
K
Michalet
V
V
Vial
T
T
Scoazec
J-Y
JY
Broussolle
C
C
D000328:Adult; D013956:Antithyroid Agents / Q000009:adverse effects*; D002231:Carbimazole / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000139:chemically induced* / Q000175:diagnosis; D005756:Gastritis / Q000139:chemically induced / Q000175:diagnosis; D006099:Granuloma / Q000139:chemically induced*; D006111:Graves Disease / Q000188:drug therapy; D006801:Humans; D008297:Male; D013274:Stomach Neoplasms / Q000175:diagnosis; D014657:Vasculitis / Q000139:chemically induced* / Q000175:diagnosis
D013956:Antithyroid Agents; D002231:Carbimazole