title: From the margins of the genome: mobile elements shape primate evolution.
abstract: As is the case with mammals in general, primate genomes are inundated with repetitive sequence. Although much of this repetitive content consists of "molecular fossils" inherited from early mammalian ancestors, a significant portion of this material comprises active mobile element lineages. Despite indications that these elements played a major role in shaping the architecture of the genome, there remain many unanswered questions surrounding the nature of the host-element relationship. Here we review advances in our understanding of the host-mobile element dynamic and its overall impact on primate evolution.
authors: Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, LA 70803, USA.
authors: Dale J
authors: DJ
authors: Hedges
authors: Mark A
authors: MA
authors: Batzer
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D005075:Biological Evolution; D018899:CpG Islands; D019175:DNA Methylation; D019143:Evolution, Molecular; D005091:Exons; D016678:Genome; D015894:Genome, Human; D018095:Germ-Line Mutation; D006801:Humans; D020084:Long Interspersed Nucleotide Elements; D008957:Models, Genetic; D016366:Open Reading Frames; D010802:Phylogeny; D011323:Primates; D012091:Repetitive Sequences, Nucleic Acid; D012190:Retroviridae / Q000235:genetics; D020086:Short Interspersed Nucleotide Elements