[Experimental therapy of Coxsackie B3 virus infection with immunomodulator contained in water-soluble Penthaphylloides fruticosa extract].
The possibility of using water-soluble substance extracted from P. fruticosa in experimental Coxsackie B3 virus infection in newborn mice was studied. The curative action of the extract was studied by its injection to the infected animals for 7 days and its prophylactic action--by introducing it 24 hours and, repeatedly, 1 hour before infection. The study revealed the increase of such characteristics as survival rate, mean survival time, body weight dynamics, as well as decreased level of virus accumulation in the brain, liver and heart tissues of the animalsunder experiment. The immunomodulating properties of the extract were shown.
Evstropov
A N
AN
Burova
L G
LG
Grek
O R
OR
Zakharova
L N
LN
Volkhonskaia
T A
TA
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use*; D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn; D001402:B-Lymphocytes / Q000276:immunology; D001835:Body Weight; D001921:Brain / Q000821:virology; D004334:Drug Administration Schedule; D029822:Enterovirus B, Human; D004769:Enterovirus Infections / Q000188:drug therapy* / Q000517:prevention & control; D006321:Heart / Q000821:virology; D018655:Lymphocyte Count; D051379:Mice; D008807:Mice, Inbred BALB C; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D031987:Potentilla; D013154:Spleen / Q000276:immunology
D000276:Adjuvants, Immunologic; D010936:Plant Extracts