title: Dietary pharmacological or excess zinc and phytase effects on tissue mineral concentrations, metallothionein, and apparent mineral retention in the newly weaned pig.
abstract: Feeding pharmacological zinc (Zn) to weaned pigs improves growth, and dietary phytase improves P and Zn availability. Metallothionein (MT) increases in the duodenum, kidney, and liver of pigs fed 1000 mg Zn/kg with phytase or 2000 mg Zn/kg with or without phytase when fed for 14 d postweaning. The goal of this study was to determine the effects of feeding pharmacological Zn and phytase on tissue minerals, MT, mineral excretion, and apparent retention. Twenty-four newly weaned pigs (20 d; 7.2 kg) were individually fed twice daily, a basal diet supplemented with 0, 1000, or 4000 mg Zn/kg as Zn oxide, without or with phytase (500 phytase units [FTU]/kg) for 14 d, followed by a basal diet (100 mg Zn/kg) without phytase for 7 d. Pigs fed 4000 mg Zn/kg without phytase had higher (p=0.01) plasma, hepatic, renal Zn, renal Cu, and hepatic, renal, and jejunal MT than pigs fed the basal diet or 1000 mg Zn/kg. Duodenal MT was higher (p=0.0001) in pigs fed 1000 and 4000 mg Zn/kg than in pigs fed the basal diet. In pigs fed 1000 and 4000 mg Zn/kg, Zn loading occurred during the first 11 d of supplementation; by d 14, excess Zn was being excreted in the feces.
authors: Department of Animal Science, Michigan State University, East Lansing, MI 48824, USA.
authors: M M
authors: MM
authors: Martínez
authors: J E
authors: JE
authors: Link
authors: G M
authors: GM
authors: Hill
mesh_terms: D010832:6-Phytase / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D003300:Copper / Q000378:metabolism; D019587:Dietary Supplements; D007583:Jejunum / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008668:Metallothionein / Q000378:metabolism*; D013552:Swine; D013997:Time Factors; D014886:Weaning; D015032:Zinc / Q000378:metabolism / Q000494:pharmacology*; D015034:Zinc Oxide / Q000494:pharmacology
chemical_list: D003300:Copper; D008668:Metallothionein; D010832:6-Phytase; D015032:Zinc; D015034:Zinc Oxide