title: Analyser-based mammography using single-image reconstruction.
abstract: We implement an algorithm that is able to decode a single analyser-based x-ray phase-contrast image of a sample, converting it into an equivalent conventional absorption-contrast radiograph. The algorithm assumes the projection approximation for x-ray propagation in a single-material object embedded in a substrate of approximately uniform thickness. Unlike the phase-contrast images, which have both directional bias and a bias towards edges present in the sample, the reconstructed images are directly interpretable in terms of the projected absorption coefficient of the sample. The technique was applied to a Leeds TOR[MAM] phantom, which is designed to test mammogram quality by the inclusion of simulated microcalcifications, filaments and circular discs. This phantom was imaged at varying doses using three modalities: analyser-based synchrotron phase-contrast images converted to equivalent absorption radiographs using our algorithm, slot-scanned synchrotron imaging and imaging using a conventional mammography unit. Features in the resulting images were then assigned a quality score by volunteers. The single-image reconstruction method achieved higher scores at equivalent and lower doses than the conventional mammography images, but no improvement of visualization of the simulated microcalcifications, and some degradation in image quality at reduced doses for filament features.
authors: School of Physics, Monash University, Victoria 3800, Australia.
authors: Dahliyani
authors: D
authors: Briedis
authors: Karen K W
authors: KK
authors: Siu
authors: David M
authors: DM
authors: Paganin
authors: Konstantin M
authors: KM
authors: Pavlov
authors: Rob A
authors: RA
authors: Lewis
mesh_terms: D000465:Algorithms; D001943:Breast Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D002114:Calcinosis / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008327:Mammography / Q000379:methods*; D019047:Phantoms, Imaging; D011230:Precancerous Conditions / Q000000981:diagnostic imaging*; D011856:Radiographic Image Enhancement / Q000379:methods*; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity