title: Genital ulcers after treatment with all-trans-retinoic acid in a child with acute promyelocytic leukemia.
abstract: All-trans-retinoic acid (ATRA) has been shown to improve the outcome of patients with acute promyelocytic leukemia (APL). However, various adverse effects of ATRA treatment have been noted, such as scrotal and genital ulcers in adult patients. The authors report genital ulcers that developed in a child with APL after ATRA treatment. An 8-year-old girl with APL was treated with ATRA for 21 days and after discontinuation of ATRA treatment she developed genital ulcers. Systemic and local antibiotic pomades were applied and the lesions improved within 15 days. In conclusion, genital ulcers may develop in children with APL as a complication of ATRA treatment and physicians should be alert to this possibility.
authors: Hacettepe University Faculty of Medicine, Department of Pediatrics, Section of Pediatric Hematology, Ihsan Dogramaci Children's Hospital, Ankara, Turkey.
authors: Selma
authors: S
authors: Unal
authors: Fatma
authors: F
authors: Gümrük
authors: Mualla
authors: M
authors: Cetin
authors: Gönül
authors: G
authors: Hiçsönmez
mesh_terms: D002648:Child; D005260:Female; D005831:Genital Diseases, Female / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications / Q000188:drug therapy*; D012883:Skin Ulcer / Q000150:complications / Q000188:drug therapy*; D016896:Treatment Outcome; D014212:Tretinoin / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D014212:Tretinoin