Effect of propofol anesthesia on pallidal neuronal discharges in generalized dystonia.
We present the results of continuous microelectrode recordings from individual pallidal neurons in patients with idiopathic torsion dystonia under different levels of propofol anesthesia. Neither the estimated plasma concentration of propofol nor the level of consciousness had a consistent effect on abnormally low neuronal firing rates. Our data support the pathophysiological model of a decreased basal ganglia output in dystonia and argue against a possible pharmacological artifact.
Steigerwald
F
F
Department of Neurology, Christian-Albrechts-University, Schittenhelmstr. 10, D-24105 Kiel, Germany.
Hinz
L
L
Pinsker
M O
MO
Herzog
J
J
Stiller
R U
RU
Kopper
F
F
Mehdorn
H M
HM
Deuschl
G
G
Volkmann
J
J
D000200:Action Potentials / Q000187:drug effects* / Q000502:physiology; D000293:Adolescent; D000328:Adult; D018686:Anesthetics, Intravenous / Q000097:blood / Q000494:pharmacology; D016477:Artifacts; D003243:Consciousness / Q000187:drug effects / Q000502:physiology; D004422:Dystonia Musculorum Deformans / Q000503:physiopathology*; D004568:Electrodiagnosis / Q000379:methods; D004594:Electrophysiology / Q000379:methods; D005917:Globus Pallidus / Q000187:drug effects* / Q000503:physiopathology*; D006801:Humans; D008839:Microelectrodes; D008875:Middle Aged; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D015742:Propofol / Q000097:blood / Q000494:pharmacology*
D018686:Anesthetics, Intravenous; D015742:Propofol