title: Acupuncture against chemotherapy-induced nausea and vomiting in pediatric oncology. Interim results of a multicenter crossover study.
abstract: OBJECTIVE
  In this multicenter crossover study, our aim was to evaluate the efficacy and acceptance of acupuncture as a supportive antiemetic approach during highly emetogenic chemotherapy in pediatric oncology.
  
  
  METHODS
  Eleven children receiving several courses of highly emetogenic chemotherapy for treatment of solid tumors were included. Randomization allocated patients to start chemotherapy either with antiemetic medication plus acupuncture or antiemetic medication alone. During all study courses, patients continued to receive their programmed and additional antiemetic medication as needed. Acupuncture was given at day 1 of chemotherapy and at subsequent days on patient's demand. The amount of baseline and additional antiemetic medication during chemotherapy was documented. Patients maintained a daily diary of vomiting episodes and completed an evaluated nausea score at the end of every course. Their body weight was taken before and after a chemotherapy course.
  
  
  RESULTS
  Twenty-two courses with or without acupuncture were compared. The benefits of acupuncture in adolescents with respect to the reduction of additional antiemetic medication were observed. Acupuncture enabled patients to experience higher levels of alertness during chemotherapy and reduced nausea and vomiting. Except for needle pain, no side effects were noted. Patient's acceptance of acupuncture was high.
  
  
  CONCLUSIONS
  Our data indicate that acupuncture might reduce antiemetic medication and episodes of vomiting in pediatric oncology.
authors: Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. tobias.reindl@charite.de
authors: Tobias K
authors: TK
authors: Reindl
authors: Wilhelm
authors: W
authors: Geilen
authors: Reinhard
authors: R
authors: Hartmann
authors: Klaus R
authors: KR
authors: Wiebelitz
authors: Guishi
authors: G
authors: Kan
authors: Ilca
authors: I
authors: Wilhelm
authors: Siegfried
authors: S
authors: Lugauer
authors: Clemens
authors: C
authors: Behrens
authors: Thomas
authors: T
authors: Weiberlenn
authors: Carola
authors: C
authors: Hasan
authors: Sven
authors: S
authors: Gottschling
authors: Tanja
authors: T
authors: Wild-Bergner
authors: Guenter
authors: G
authors: Henze
authors: Pablo Hernáiz
authors: PH
authors: Driever
mesh_terms: D015670:Acupuncture Therapy; D000293:Adolescent; D000932:Antiemetics / Q000008:administration & dosage / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D018592:Cross-Over Studies; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D009325:Nausea / Q000139:chemically induced* / Q000517:prevention & control*; D011446:Prospective Studies; D016896:Treatment Outcome; D014839:Vomiting / Q000139:chemically induced* / Q000517:prevention & control*
chemical_list: D000932:Antiemetics; D000970:Antineoplastic Agents