title: Compensatory lung growth: protein, DNA and RNA lung contents in undernourished trilobectomized rats.
abstract: OBJECTIVE
  To demonstrate compensatory lung growth (CLG) by lung contents of proteins, DNA, and RNA in undernourished young adult rats, submitted to pulmonary trilobectomy.
  
  
  METHODS
  We used 137 male Wistar rats, randomly distributed into 9 groups; they were submitted to three treatments (control, thoracotomy, and trilobectomy), and sacrificed at three different times (7, 30, and 90 days). In trilobectomy we removed the right median, accessory, and caudal lobes. We studied lung proteins, DNA, and RNA contents.
  
  
  RESULTS
  In the cranial lobe and left lung, protein content was higher in trilobectomized rats however there was insufficient CLG to make up for the loss. The increase of DNA in the cranial lobe and left lung of trilobectomized rats was sufficient to compensate for this loss, resulting in a similar content to controls. RNA content in trilobectomized rats, was higher in the cranial lobe and left lung, more efficient in the cranial lobe, but less than in the other groups.
  
  
  CONCLUSIONS
  CLG occurred in trilobectomized rats, probably with cell hyperplasia and little hypertrophy, due to the large DNA compensation and small RNA compensation. This was markedly different to well-nourished animals, who had pronounced hypertrophy.
authors: Department of Orthopedics and Surgery, State University of São Paulo (UNESP), Botucatu, SP, Brazil. ruizraul@fmb.unesp.br
authors: Raul Lopes
authors: RL
authors: Ruiz Júnior
authors: Lídia Raquel
authors: LR
authors: de Carvalho
authors: Antonio José Maria
authors: AJ
authors: Cataneo
mesh_terms: D000818:Animals; D004247:DNA / Q000032:analysis*; D006965:Hyperplasia / Q000473:pathology; D006984:Hypertrophy / Q000473:pathology; D008168:Lung / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008297:Male; D044342:Malnutrition / Q000473:pathology*; D011506:Proteins / Q000032:analysis*; D012313:RNA / Q000032:analysis*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D011506:Proteins; D012313:RNA; D004247:DNA