Glutathione-S-transferase polymorphism and clinical features of acute drug poisoning in children.
We studied the association of GSTM1 and GSTT1 and GSTP1 Ile105-Val105 polymorphism with the duration of intoxication, polyorgan failure, and severity of drug poisoning in children. The combination of GSTM1 and GSTT1 zero genotypes is a favorable sign for the duration of intoxication and severity of the disease.
Vavilin
V A
VA
Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Medical Sciences, Russia. drugsmet@soramn.ru
Safronova
O G
OG
Manankin
N A
NA
Kaznacheeva
L F
LF
Lyakhovich
V V
VV
D002648:Child; D016001:Confidence Intervals; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D016017:Odds Ratio; D011041:Poisoning / Q000201:enzymology / Q000235:genetics*; D011110:Polymorphism, Genetic
D005982:Glutathione Transferase