title: Effects of volatile constituents of a rosemary extract on allergic airway inflammation related to house dust mite allergen in mice.
abstract: Perilla leaf extract is known to have anti-inflammatory properties. Recently, we have demonstrated that rosmarinic acid, a polyphenolic liquid component in perilla, inhibits the allergic airway inflammation induced by house dust mites (HDMs) in vivo. The purpose of this study was to evaluate the effects of intratracheal (i.t.) exposure to volatile constituents of a rosemary extract (VR), gaseous components in perilla, on a murine model of allergic asthma induced by HDM. C3H/HeN mice were treated 7 times weekly with i.t. exposure. The HDM allergen challenge elicited a pulmonary eosinophilic inflammation accompanied by an increase in the lung expression of interleukin (IL)-5, IL-13, and eotaxin. VR inhibited increases in the number of eosinophils, neutrophils, and mononuclear cells around the airways and those in the bronchoalveolar lavage fluid. VR exposure also significantly suppressed the expression of IL-13 enhanced by HDM allergen. These results suggest that i.t. exposure to VR can, at least partially, prevent allergic airway inflammation induced by HDM. The preventive effect is associated with inhibition of the enhanced local expression of IL-13.
authors: Inhalation Toxicology & Pathophysiology Research Team, National Institute for Environmental Studies, Ibaraki, Japan.
authors: Ken-Ichiro
authors: K
authors: Inoue
authors: Hirohisa
authors: H
authors: Takano
authors: Akira
authors: A
authors: Shiga
authors: Yoji
authors: Y
authors: Fujita
authors: Hiroaki
authors: H
authors: Makino
authors: Rie
authors: R
authors: Yanagisawa
authors: Takamichi
authors: T
authors: Ichinose
authors: Yoji
authors: Y
authors: Kato
authors: Tomozo
authors: T
authors: Yamada
authors: Toshikazu
authors: T
authors: Yoshikawa
mesh_terms: D000818:Animals; D039741:Antigens, Dermatophagoides / Q000276:immunology*; D001249:Asthma / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002452:Cell Count; D054413:Chemokine CCL11; D054414:Chemokine CCL17; D054407:Chemokine CCL4; D019742:Chemokines, CC / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004804:Eosinophils / Q000166:cytology / Q000187:drug effects; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control; D018793:Interleukin-13 / Q000378:metabolism; D015848:Interleukin-5 / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects; D019402:Macrophage Inflammatory Proteins / Q000378:metabolism; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011657:Pulmonary Eosinophilia / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control; D027542:Rosmarinus / Q000737:chemistry*; D014132:Trachea; D014835:Volatilization
chemical_list: D039741:Antigens, Dermatophagoides; C515457:Ccl11 protein, mouse; C499538:Ccl17 protein, mouse; D054413:Chemokine CCL11; D054414:Chemokine CCL17; D054407:Chemokine CCL4; D019742:Chemokines, CC; D018793:Interleukin-13; D015848:Interleukin-5; D019402:Macrophage Inflammatory Proteins; D010936:Plant Extracts