RNAi: the nuts and bolts of the RISC machine.
Research on RNA interference and microRNA pathways continues to accelerate. Combinations of biochemical, genetic, and structural approaches are providing new insights into the mechanism by which small, approximately 21 nt long RNAs find their way into the RISC effector complexes and how the RISCs execute their mission of RNA-guided posttranscriptional gene silencing.
Filipowicz
Witold
W
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland. filipowi@fmi.ch
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism; D020868:Gene Silencing; D035683:MicroRNAs / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological; D034622:RNA Interference / Q000502:physiology*; D034743:RNA-Induced Silencing Complex / Q000737:chemistry / Q000235:genetics / Q000502:physiology
D035683:MicroRNAs; D034743:RNA-Induced Silencing Complex