Treatment of locally advanced non-small cell lung cancer: what we have and have not learned over the past decade.
Over the past decade, clinical trials for good-performance status patients with unresectable stage III non-small cell lung cancer have shown that concurrent chemoradiation therapy (chemoRT) provides improved survival over sequential chemoradiation therapy. The available data suggest that induction chemotherapy preceding concurrent chemoRT does not further improve survival. Much remains to be learned about optimizing concurrent chemoRT in this setting, including identifying doses and schedules of chemotherapy that can maintain efficacy and reduce toxicity, as well determining optimal RT doses.
Curran
Walter J
WJ
Department of Radiation Oncology, Kimmel Cancer Center, Jefferson Medical College, 111 S. 11th Street, Philadelphia, PA 19107, USA. walter.curran@mail.tju.edu
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000628:therapy*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000628:therapy*; D020266:Radiotherapy, Conformal