Three cases of diffuse large B-cell lymphoma of the mandible treated with radiotherapy and chemotherapy.
METHODS
We report three cases of diffuse large B-cell lymphoma of the mandible and a review of the literature. All 3 of our patients had stage I AE disease and had complete remission for more than 2 years after 42-46 Gy of irradiation to the primary tumor with regional lymph nodes and 3 courses of chemotherapy consisting of cyclophosphamide, adriamycin, vincristine, and predonisolone (CHOP). Literature analysis, although biased toward published data, indicated that the 3-year disease-specific survival rates for non-Hodgkin's lymphoma (NHL) of the mandible were 90.5% and 47.6% for stages I and II, respectively. The treatment results for NHL of the mandible may be similar to general primary bone NHL and to other extranodal NHL's.


CONCLUSIONS
Radiotherapy alone is not sufficient for tumor control for stage I+II, disease, and combination chemotherapy may be needed.
Someya
Masanori
M
Department of Radiology, Sapporo Medical University, School of Medicine, Sapporo, Hokakaido, Japan.
Sakata
Koh-Ichi
K
Nagakura
Hisayasu
H
Itou
Katsuya
K
Nakata
Kensei
K
Oouchi
Atsushi
A
Satoh
Masaaki
M
Hareyama
Masato
M
D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000532:radiotherapy; D016393:Lymphoma, B-Cell / Q000628:therapy*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000628:therapy*; D008297:Male; D008339:Mandibular Neoplasms / Q000628:therapy*; D008875:Middle Aged