High-potency human immunodeficiency virus vaccination leads to delayed and reduced CD8+ T-cell expansion but improved virus control.
CD8(+) T lymphocytes are thought to play an important role in the control of acute and chronic human immunodeficiency virus infections. However, there is a significant delay between infection and the first observed increase in virus-specific CD8(+) T-cell numbers. Prior to this time, viral kinetics are not significantly different between controls and vaccinees. Surprisingly, higher initial virus-specific CD8(+) T-cell numbers lead to a longer delay prior to initial CD8(+) T-cell expansion, and slower CD8(+) T-cell increases. Nevertheless, higher initial CD8(+) T-cell numbers were associated with reduced peak and chronic viral loads and reduced CD4(+) T-cell depletion.
Davenport
Miles P
MP
Department of Haematology, Prince of Wales Hospital and Centre for Vascular Research, University of New South Wales, Kensington, Australia.
Zhang
Lei
L
Bagchi
Ansuman
A
Fridman
Arthur
A
Fu
Tong-Ming
TM
Schleif
William
W
Shiver
John W
JW
Ribeiro
Ruy M
RM
Perelson
Alan S
AS
D016915:AIDS Vaccines / Q000009:adverse effects / Q000276:immunology*; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology* / Q000302:isolation & purification*; D018655:Lymphocyte Count; D008251:Macaca; D016865:Reassortant Viruses / Q000276:immunology / Q000302:isolation & purification; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology* / Q000302:isolation & purification; D037182:T-Cell Antigen Receptor Specificity; D014611:Vaccination; D019562:Viral Load
D016915:AIDS Vaccines