Cryptococcal meningitis in a patient with X-linked hyper-IgM1 syndrome.
A case is reported of cryptococcal meningitis in a 27-y-old male suffering from X-linked hyper-IgM1 syndrome. This congenital disorder is characterized by multiple infections of the respiratory and gastrointestinal tracts, but also opportunistic infections commonly seen in patients with cell-mediated immunity. His clinical recovery was good but the need for life-long secondary chemoprophylaxis to prevent relapses is unknown.
de Górgolas
Miguel
M
División de Enfermedades Infecciosas, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain. mgorgolas@fjd.es
Erice
Alejo
A
Gil
Antonio
A
Gutiérrez
Javier
J
Rivas
Pablo
P
Hernando
Carlos
C
Rodríguez
Ma Cruz García
MC
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D003840:Deoxycholic Acid / Q000627:therapeutic use; D004338:Drug Combinations; D015725:Fluconazole / Q000627:therapeutic use; D040181:Genetic Diseases, X-Linked / Q000150:complications*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications* / Q000235:genetics; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D016919:Meningitis, Cryptococcal / Q000188:drug therapy / Q000276:immunology*
D000935:Antifungal Agents; D004338:Drug Combinations; D007075:Immunoglobulin M; D003840:Deoxycholic Acid; D000666:Amphotericin B; C059765:amphotericin B, deoxycholate drug combination; D015725:Fluconazole