title: Effect of insulin on NO production by monocytes from patients with metabolic cardiovascular syndrome.
abstract: Basal and insulin-induced production of NO by monocytes significantly increased in patients with metabolic cardiovascular syndrome. Plasma insulin concentration in these patients was below the control. No intergroup differences were found in C-peptide concentration. A negative correlation was revealed between insulin-induced NO production by monocytes and C-peptide/insulin ratio in patients. The role of monocytes on the regulation of vascular tone via NO production in patients with metabolic cardiovascular syndrome is discussed.
authors: Institute of Cardiology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences; Siberian State Medical University, Tomsk, Russia. liv@cardio.tsu.ru
authors: T E
authors: TE
authors: Suslova
authors: A V
authors: AV
authors: Sitozhevskii
authors: O N
authors: ON
authors: Ogurkova
authors: O V
authors: OV
authors: Gruzdeva
authors: T S
authors: TS
authors: Fedorova
authors: R S
authors: RS
authors: Karpov
mesh_terms: D006801:Humans; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism*; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism*; D009569:Nitric Oxide / Q000096:biosynthesis*
chemical_list: D007328:Insulin; D009569:Nitric Oxide