Rhabdomyolysis induced by psychotropic drugs.
A 41-year-old man experienced continuous convulsions, unconsciousness, and a high temperature. His laboratory findings revealed an increase in serum creatine phosphokinase, serum myoglobulin, and urinary myoglobulin levels. He had taken many psychotropic drugs as treatment for schizophrenia and was very dehydrated. Because a diagnosis of rhabdomyolysis was suspected, Tc-99m HMDP bone scintigraphy was performed. It showed diffusely increased soft tissue uptake in his shoulder girdles, vertebral area, psoas iliac muscles, and gluteofemoral muscles, leading to a diagnosis of rhabdomyolysis. Bone scintigraphy is useful in making an early diagnosis and evaluating the location and degree of muscle injury in rhabdomyolysis.
Kaida
Hayato
H
Division of Nuclear Medicine, Department of Radiology, Kurume University School of Medicine, Kurume City, Japan. hayato@med.jurume-u.ac.jp
Ishibashi
Masatoshi
M
Nishida
Hidemi
H
Baba
Kenkichi
K
Hayabuchi
Naofumi
N
D000328:Adult; D001842:Bone and Bones / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging; D011619:Psychotropic Drugs / Q000009:adverse effects*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012206:Rhabdomyolysis / Q000139:chemically induced*; D013669:Technetium Tc 99m Medronate / Q000031:analogs & derivatives
D011619:Psychotropic Drugs; D019275:Radiopharmaceuticals; C024226:technetium Tc 99m hydroxymethylene diphosphonate; D013669:Technetium Tc 99m Medronate