Miniaturized detection technology in molecular diagnostics.
Miniaturization of genetic tests represents the convergence of molecular biology and engineering and is leading to a new class of small analyzers and test systems for genetic testing with improved analytical characteristics. Miniaturization initially focused on devices that contained micrometer-sized features designed for a particular analytical purpose (e.g., filters for cell isolation and chips for capillary electrophoresis). Now, the focus is shifting to analytical applications based on nano-sized objects such as nanotubes, nanochannels, nanoparticles, nanopores and nanocapacitors. These nanofabricated objects provide new tools for sequencing of nucleic acids and rapid, multiplexed, nucleic acid detection.
Kricka
Larry J
LJ
Department of Pathology & Laboratory Medicine, University of Pennsylvania School of Medicine, 7.103 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA. kricka@mail.med.upenn.edu
Park
Jason Y
JY
Li
Sam F Y
SF
Fortina
Paolo
P
D000818:Animals; D004563:Electrochemistry; D019075:Electrophoresis, Capillary; D006801:Humans; D046228:Microarray Analysis; D008904:Miniaturization / Q000295:instrumentation / Q000379:methods*; D025202:Molecular Diagnostic Techniques / Q000295:instrumentation / Q000379:methods*; D009696:Nucleic Acids / Q000032:analysis / Q000235:genetics
D009696:Nucleic Acids