Relation of platelet activation to coronary angiographic severity and collateralization.
We investigated whether platelet activation can be correlated with angiographic severity and the degree of collateralization in coronary artery disease (CAD), as well as endothelial damage/dysfunction. No studies have attempted to correlate platelet activation status, as measured by soluble plasma markers (soluble CD40 ligand, soluble P-selectin, soluble glycoprotein V), with the appearance of diseased coronary arteries. We found evidence of increased platelet activation in CAD, but a lack of correlation between the degree of platelet activation and the angiographic disease severity, which may reflect the presence of disease elsewhere or the presence of coronary atheroma not detected by angiography.
Tan
Kiat T
KT
Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, United Kingdom.
Tayebjee
Muzahir H
MH
Macfadyen
Robert J
RJ
Lip
Gregory Y H
GY
D000368:Aged; D015415:Biomarkers / Q000032:analysis; D023201:CD40 Ligand / Q000032:analysis; D016022:Case-Control Studies; D003097:Collateral Circulation / Q000502:physiology*; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging* / Q000401:mortality; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D015539:Platelet Activation / Q000502:physiology*; D011336:Probability; D011379:Prognosis; D012016:Reference Values; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D016019:Survival Analysis
D015415:Biomarkers; D019007:P-Selectin; D023201:CD40 Ligand