[The prognostic value of human neuroendocrine clone on colorectal carcinoma].
OBJECTIVE
To demonstrate the prognostic value of neuroendocrine clone on colorectal carcinoma.


METHODS
The immunochemistry methods were used to investigate the percent of neuroendocrine carcinoma in 73 human colorectal carcinoma. Retrospective analysis and follow-up were carried out in all patients.


RESULTS
In all 73 cases of colorectal carcinoma, the total percentage of neuroendocrine carcinoma was 17.8%. Neuroendocrine carcinoma included 11 synapse positive, 6 chromogranin positive and 4 both positive. The major factors related to the prevalence of neuroendocrine carcinoma were sex, age, tumor location and Dukes' stage. And the 1-year survival rate of the patients who suffered from neuroendocrine carcinoma is obviously lower than that of other colorectal carcinoma.


CONCLUSIONS
The neuroendocrine carcinoma is a special kind of human colorectal carcinoma, and neuroendocrine clone may be a new marker of the malignant potency. The neuroendocrine clone has its prognostic value and may be a novel therapeutic target.
Yang
Xiao-dong
XD
Department II of Surgery, The People's Hospital, Peking University, Beijing 100044, China.
Wang
Shan
S
Meng
Hui-yan
HY
Ye
Ying-jiang
YJ
Yu
You-zhi
YZ
Jiang
Ke-wei
KW
Yang
Shen
S
Qu
Jun
J
Fang
Wei-gang
WG
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018278:Carcinoma, Neuroendocrine / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D002864:Chromogranins / Q000096:biosynthesis; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D016704:Synapsins / Q000096:biosynthesis
D002864:Chromogranins; D016704:Synapsins