Toxic epidermal necrolysis secondary to angioimmunoblastic T-cell lymphoma.
A 67-year-old man presented with a history of lymphadenopathy, fevers and separate skin eruptions of erythrodermic spongiotic dermatitis initially and subsequent toxic epidermal necrolysis. Initial lymph node biopsies showed non-specific granulomatous changes, and skin biopsies and bone marrow aspirate were not diagnostic. His toxic epidermal necrolysis responded well to 3 days of intravenous immunoglobulin. The patient was discharged from hospital and reviewed regularly as an outpatient. Due to persisting lymphadenopathy, further lymph node biopsy led to the diagnosis of angioimmunoblastic T-cell lymphoma, a rare form of peripheral T-cell lymphoma with a poor prognosis. At the time of diagnosis his condition deteriorated rapidly and he died soon after.
Jones
Brad
B
Department of Dermatology, Our Lady of Lourdes Hospital, Drogheda, Ireland. bradjones@ausdoctors.net
Vun
Yin
Y
Sabah
Muna
M
Egan
Conleth A
CA
D000368:Aged; D017809:Fatal Outcome; D006258:Head and Neck Neoplasms / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000150:complications* / Q000175:diagnosis; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008198:Lymph Nodes / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000175:diagnosis; D008297:Male; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*
D016756:Immunoglobulins, Intravenous