Prognostic value of serum CA-125 measurements on stimulation day 1 and on the day of oocyte pickup in the prediction of IVF treatment outcome.
OBJECTIVE
To assess whether serum levels of CA-125, a proposed marker of endometrial receptivity, are associated with pregnancy after IVF.


METHODS
42 IVF pregnancies were matched with nonpregnant controls. Twenty-eight additional unmatched pregnancies were included for the comparison of pregnancy outcomes. CA-125 concentrations were measured on stimulation day 1 (SD1) and at oocyte pickup (OPU). We analyzed association between CA-125 levels and establishment of pregnancy and its outcome; correlation between CA-125 concentrations and other parameters; differences in CA-125 levels between SD1 and OPU.


RESULTS
In pregnant, but not in nonpregnant patients, CA-125 levels decreased significantly from SD1 to OPU. There was no significant difference in CA-125 levels at either time point between pregnant and nonpregnant subjects. No significant correlation was found between CA-125 levels and any other clinical or laboratory parameters.


CONCLUSIONS
CA-125 measurements at the beginning of stimulation or at oocyte retrieval are not useful in predicting IVF outcome.
Hauzman
Erik E
EE
First Department of Obstetrics and Gynecology, Semmelweis University, Faculty of Medicine, Budapest, Hungary. humanic@noi1.sote.hu
Lagarde
Ana R
AR
Nagy
Katalin
K
Fancsovits
Péter
P
Murber
Akos
A
Jánoki
Gyözö
G
Papp
Zoltán
Z
Urbancsek
János
J
D000328:Adult; D018394:CA-125 Antigen / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D009865:Oocytes / Q000502:physiology; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome; D011379:Prognosis; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome
D018394:CA-125 Antigen