Successful pregnancy in a gonadectomized woman with 46,XY gonadal dysgenesis and gonadoblastoma.
OBJECTIVE
To present a case of successful pregnancy after conservative bilateral gonadectomy without adjuvant chemotherapy and radiotherapy in a 46,XY gonadal dysgenetic woman with gonadoblastoma and malignant germ cell tumor.


METHODS
Case report.


METHODS
Infertility center in university hospital.


METHODS
An 18-year-old female with 46,XY karyotype underwent bilateral gonadectomy, and the pathology revealed gonadoblastoma with malignant mixed germ cell tumor.


METHODS
Chromosomal analysis, bilateral gonadectomy, donor oocyte, and IVF program.


METHODS
Tumor markers and pregnancy result.


RESULTS
The patient was free from tumor recurrence after 13 years' follow-up. A successful twin pregnancy was achieved after oocyte donation and IVF.


CONCLUSIONS
Gonadectomy without adjuvant therapies could be done in 46,XY gonadal dysgenetic women with gonadoblastoma in view of preservation of future fertility.
Chen
Mei-Jou
MJ
Department of Obstetrics and Gynecology, College of Medicine and Hospital, National Taiwan University, Taipei, Taiwan.
Yang
Jehn-Hsiahn
JH
Mao
Tusi-Lien
TL
Ho
Hong-Nerng
HN
Yang
Yu-Shih
YS
D000328:Adult; D005260:Female; D006061:Gonadal Dysgenesis, 46,XY / Q000235:genetics / Q000601:surgery*; D018238:Gonadoblastoma / Q000235:genetics / Q000601:surgery*; D006801:Humans; D007231:Infant, Newborn; D050498:Live Birth; D008297:Male; D010051:Ovarian Neoplasms / Q000235:genetics / Q000601:surgery*; D010052:Ovariectomy / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011272:Pregnancy, Multiple