Comparisons of the outcomes on control, type of management and complications status in early onset and late onset type 2 diabetes in Asia.
OBJECTIVE
To describe the clinical characteristics and chronic diabetic complications in early (EOD) and late onset type 2 diabetes mellitus (LOD) in Asia.


METHODS
Retrospective collection of information (basic patient data, treatment received for diabetes, hypertension, dyslipidaemia, clinical measurements, complications, life-style management, etc.) on paper form and prospective collection of blood samples for HbA(1c) assessment were performed. Means, proportions and associated factors were analyzed using non-parametric and logistic regression.


RESULTS
The frequency of EOD (<30 years) varies in different Asian countries (0.4-5.3%). Overweight (BMI>or=23 kg/m2) was common in both EOD (60%) and LOD (66%). EOD was characterized by significantly higher levels of HbA(1c) (median 8.9% versus 7.9%) and FPG (median 9.8 mmol/L versus 8.3 mmol/L) but hypertension was less common (43% versus 59%). Lipid profiles (cholesterol and triglycerides) were similar between both groups of patients. Cataract was more common in LOD and was associated with onset age and diabetes duration whereas an increase in frequency of advanced eye disease, retinopathy and history of photocoagulation was found in EOD cohort.


CONCLUSIONS
In addition to diabetic control and duration of the disease, the onset age conferred risk to certain subsets of chronic complications in type 2 diabetes population.
Chuang
Lee-Ming
LM
Department of Internal Medicine, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, Taiwan. leeming@ha.mc.ntu.edu.tw
Soegondo
Sidartawan
S
Soewondo
Pradana
P
Young-Seol
Kim
K
Mohamed
Mafauzy
M
Dalisay
Edith
E
Go
Ruby
R
Lee
Warren
W
Tong-Yuan
Tai
T
Tandhanand
Sunthorn
S
Nitiyanant
Wannee
W
The-Trach
Mai
M
Cockram
Clive
C
Jing-Ping
Yeo
Y
D000328:Adult; D017668:Age of Onset; D000368:Aged; D001208:Asia / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000453:epidemiology* / Q000628:therapy; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D015994:Incidence; D008875:Middle Aged; D012189:Retrospective Studies
D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents