[Changes of serum leptin level in pulmonary infection-induced multiple organ dysfunction syndrome].
OBJECTIVE
To determine serum levels of leptin and some related cytokines in severely ill patients, including severe pulmonary infection-induced multiple organ dysfunction syndrome (MODS), acute myocardial infarction (AMI) and arrhythmia (AR), and to explore the possible role of leptin in the pathogenesis and diagnosis of MODS.


METHODS
Radioimmunoassay was used to determine leptin, fatty acid binding protein (FABP), transferrin (Ferr) and interleukin-1beta (IL-1beta), and enzyme-linked immuno adsorbent assay (ELISA) was used to assess C reactive protein (CRP).


RESULTS
Compared with normal individuals, leptin levels in MODS, AMI and AR patients increased significantly (all P<0.01). CRP and IL-1beta levels also increased significantly in MODS, AMI and AR patients, but the changes were more marked (all P<0.05) in MODS patients than in the patients of other two diseases (both P<0.05). Though FABP and Ferr levels of patients in all the three groups of patients showed a trend toward increase, especially in MODS patients, there was no significant difference between them and normal individuals.


CONCLUSIONS
Serum leptin level increases significantly in pulmonary infection-induced MODS patients with a simultaneous increase of CRP and IL-1beta levels, and the result suggests that leptin plays a possible role in the pathogenesis and prognosis of MODS.
Yan
Guang-tao
GT
Research Laboratory of Biochemistry, Basic Medical Institute, General Hospital of PLA, Beijing 100853, China. YAN301@263.net
Xue
Hui
H
Lin
Ji
J
Hao
Xiu-hua
XH
Zhang
Kai
K
Wang
Lu-huan
LH
D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D050556:Fatty Acid-Binding Proteins / Q000097:blood; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood; D020738:Leptin / Q000097:blood*; D009102:Multiple Organ Failure / Q000097:blood* / Q000209:etiology; D011014:Pneumonia / Q000097:blood / Q000150:complications*
D050556:Fatty Acid-Binding Proteins; D053583:Interleukin-1beta; D020738:Leptin; D002097:C-Reactive Protein