Effect of active fraction of cerebral on expression of caspase-3 and beta-amyloid precursor protein during therapy of hemorrhagic stroke in the acute and delayed periods.
Active anti-stroke fraction of Cerebral preparation (extract of water-soluble molecules from brain tissue of animals with hemorrhagic stroke) decreased caspase-3 expression and improved survival of experimental animals in the acute period after hemorrhagic stroke.
Makarenko
A N
AN
Institute of Pharmacology and Toxicology, Ukrainian Academy of Sciences, Kiev.
Vasil'eva
I G
IG
Chopik
N G
NG
Galanta
E S
ES
Tsyubko
O I
OI
Oleksenko
N P
NP
D000208:Acute Disease; D016564:Amyloid beta-Protein Precursor / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D000818:Animals; D053148:Caspase 3; D061945:Caspase Inhibitors; D020169:Caspases / Q000235:genetics / Q000378:metabolism; D002543:Cerebral Hemorrhage / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism; D051381:Rats; D020521:Stroke / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D014020:Tissue Extracts / Q000494:pharmacology / Q000627:therapeutic use*
D016564:Amyloid beta-Protein Precursor; D061945:Caspase Inhibitors; C506223:Cerebral preparation; D012333:RNA, Messenger; D014020:Tissue Extracts; C505410:Casp3 protein, rat; D053148:Caspase 3; D020169:Caspases