Hemispheric asymmetry emerges at distinct parts of the occipitotemporal cortex for objects, logograms and phonograms: a functional MRI study.
Behavioral and neuropsychological studies have suggested that the right hemisphere has a special advantage in the visual recognition of logograms. While this long-standing 'right hemisphere hypothesis' has never been investigated systematically by previous neuroimaging studies, a candidate neural substrate of such asymmetry might be found within the occipitotemporal cortex that is known to exhibit lateralized response to a certain class of stimuli, such as letters and faces. The present study examined the hemispheric specialization of brain activation during naming of objects, logograms and phonograms using functional magnetic resonance imaging. The three types of stimuli overall produced left-predominant activation of the perisylvian and inferior parietal regions relative to the resting baseline. This inter-hemispheric difference was significant irrespective of the stimuli type. In the occipitotemporal cortex, six subregions showing lateralized response were identified. That is, the three stimuli commonly produced left-lateralized response in the posterior fusiform and superior temporal gyri and right-lateralized response in the extrastriate cortex. Only logograms and objects produced a distinct cluster showing right-lateralized activation in the medial anterior fusiform gyrus associated with semantic knowledge, whereas only phonograms produced a left-lateralized activation in the posterior middle temporal cortex close to the site associated with visual perception of alphabetical letters. These findings suggest that while these stimuli similarly recruit the left perisylvian language area as a common neural component for naming, processing of objects and logograms becomes left-lateralized only in the downstream of the occipitotemporal cortex. By contrast, visual processing of phonograms is specialized to the left hemisphere in earlier stages of the area. The present data provide further evidence suggesting that both the left-right and anterior-posterior axes of the occipitotemporal cortex are differentially tuned according to the specific features of visual stimuli.
Nakamura
Kimihiro
K
Human Brain Research Center, Kyoto University Graduate School of Medicine, Japan. kimihiro@m.u-tokyo.ac.jp
Oga
Tatsuhide
T
Okada
Tomohisa
T
Sadato
Norihiro
N
Takayama
Yoshihiro
Y
Wydell
Taeko
T
Yonekura
Yoshiharu
Y
Fukuyama
Hidenao
H
D000328:Adult; D003627:Data Interpretation, Statistical; D005556:Form Perception / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009778:Occipital Lobe / Q000502:physiology*; D010775:Photic Stimulation; D011932:Reading; D012660:Semantics; D013067:Speech Perception / Q000502:physiology*; D013702:Temporal Lobe / Q000502:physiology*