title: Idiopathic complex polysaccharide storage disease in an abyssinian cat.
abstract: A glycogen storage disease affecting primarily the skeletal muscle and, to a lesser degree, the cardiac muscle, spinal cord, and brain was diagnosed in a 10-year-old neutered Abyssinian cat with a 4-year history of paresis progressing to acute paralysis. Microscopically, these tissues contained inclusions that were pale basophilic in hematoxylin and eosin-stained slides, diastase resistant, periodic acid-Schiff positive, and blue-to-almost black with iodine stain. By transmission electron microscopy, the inclusions consisted of cytosolic, usually sharply demarcated, nonmembrane-bound deposits of finely granular and filamentous material. On the basis of the structural and histochemical staining characteristics, the inclusions were believed to be aggregates of abnormally stored, unbranched glycogen. A defect in glucose metabolism is suspected to be the underlying pathologic process, but an exact cause remains elusive.
authors: Animal Disease Diagnostic Laboratory, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907-2065, USA. ilangohr@purdue.edu
authors: I M
authors: IM
authors: Langohr
authors: M
authors: M
authors: Tanabe
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D002490:Central Nervous System / Q000648:ultrastructure*; D006008:Glycogen Storage Disease / Q000150:complications / Q000473:pathology* / Q000662:veterinary*; D006652:Histological Techniques / Q000662:veterinary; D046529:Microscopy, Electron, Transmission / Q000662:veterinary; D018482:Muscle, Skeletal / Q000378:metabolism / Q000648:ultrastructure*; D009206:Myocardium / Q000648:ultrastructure*; D010291:Paresis / Q000209:etiology / Q000662:veterinary*; D013194:Staining and Labeling