title: Design and syntheses of melanocortin subtype-4 receptor agonists. Part 2: discovery of the dihydropyridazinone motif.
abstract: Optimization of the biological activity of a new class of non-peptidyl, pyridazinone derived human melanocortin subtype-4 receptor agonists is disclosed.
authors: Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065-0900, USA. f_ujjainwalla@merck.com
authors: Feroze
authors: F
authors: Ujjainwalla
authors: Daniel
authors: D
authors: Warner
authors: Christine
authors: C
authors: Snedden
authors: Ricky D
authors: RD
authors: Grisson
authors: Thomas F
authors: TF
authors: Walsh
authors: Matthew J
authors: MJ
authors: Wyvratt
authors: Rubana N
authors: RN
authors: Kalyani
authors: Tanya
authors: T
authors: Macneil
authors: Rui
authors: R
authors: Tang
authors: David H
authors: DH
authors: Weinberg
authors: Lex
authors: L
authors: Van der Ploeg
authors: Mark T
authors: MT
authors: Goulet
mesh_terms: D015195:Drug Design; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D011724:Pyridazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D044105:Receptor, Melanocortin, Type 4 / Q000819:agonists* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: C470072:MC4R protein, human; D011724:Pyridazines; D044105:Receptor, Melanocortin, Type 4