[Nanobiotechnological gene transfer vectors in gene therapy].
Gene therapy has shown great potentials in the treatment of a number of human key diseases, such as genetic diseases, cancer and so on, yet there are still some big challenges to face. One of these challenges is how to develop efficient, safe, targeting and controlled release gene delivery systems. With the progress of nanobiotechnologies, some nanobiomaterials such as liposome, poly (D,L lactic-co-glycolic acid) and poly (L-lactide) have great potencies in developing the ideal gene transfer vector, just because of their properties of biocompatibility, bio-degradation, controllable release, easy modification for targeting and so on. In this review is presented a summary of the excellent properties of the nanobiotechnological gene delivery systems and their recent encouraging advances.
Zhang
Xiaowei
X
Key Laboratory of Biotherapy of Human Diseases of Ministry of Education, West China Hospital of Sichuan University, Chengdu 610041, China.
Tian
Ling
L
Wei
Yuquana
Y
D001672:Biocompatible Materials; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry; D036103:Nanotechnology; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
D001672:Biocompatible Materials; D008081:Liposomes; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid