Effects of surgical resection and adjuvant therapy on pediatric intracranial ependymomas.
The optimal therapy of pediatric ependymomas is controversial. The benefit of surgical resection is widely accepted, but the role of adjuvant therapy is subject to debate. Due to the relatively low survival rates of ependymoma patients, as well as the tumor's high recurrence rates, further research into the efficacy of treatment strategies and adjuvant therapy is necessary. Extent of resection remains the most important determinant of survival in patients with ependymomas. Expectantly, gross total resection yields the best outcome for patients. The optimal roles of chemotherapy and radiation therapy are poorly understood. A closer look at the efficacy of tailored radiation therapy and the possible use of chemotherapy to delay radiation therapy sheds light on potential treatment modalities for ependymomas. The greatest increase in survival on the ependymoma population will likely come from an increase in the rate of complete resections. An improvement in the efficacy of radiation therapy in addition to an understanding of chemotherapy protocols and treatment durations will hopefully provide further means for successfully treating ependymomas.
Krieger
Mark D
MD
Division of Neurosurgery, Childrens Hospital of Los Angeles, Department of Neurological Surgery, Keck School of Medicine, University of Southern California, 1300 N Vermont Ave, 1006, Los Angeles, CA 90027, USA. mkrieger@chla.usc.edu
Bowen
Ira E
IE
D001932:Brain Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery*; D002648:Child; D004806:Ependymoma / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery*; D006801:Humans; D019635:Neurosurgical Procedures; D018714:Radiotherapy, Adjuvant; D015996:Survival Rate