A model of the pacemaking neuron of the respiratory central pattern generator.
We have developed a model of the mammalian respiratory central pattern generator (rCPG) to mimic the salient characteristics of its constituent medullary neurons. This model is designed as a network of Hodgkin-Huxley-type medullary neurons driven by a pacemaking neuron from the pre-Bötzinger complex. Here, we present the results of our model of this pacemaking neuron, based on available voltage clamp data. Implications for the behavior of the rCPG are discussed.
Amini
Behrang
B
Department of Neurobiology and Anatomy, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Behrang.Amini@uth.tmc.edu
Bidani
Akhil
A
Zwischenberger
Joseph B
JB
Clark
John W
JW
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D003198:Computer Simulation; D005246:Feedback / Q000502:physiology; D006801:Humans; D008168:Lung / Q000294:innervation* / Q000502:physiology*; D008526:Medulla Oblongata / Q000502:physiology; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D015656:Respiratory Mechanics / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology