title: The association between microsomal epoxide hydrolase genotypes and esophageal squamous-cell-carcinoma in Taiwan: interaction between areca chewing and smoking.
abstract: One hundred and forty-five ESCC patients and 352 controls were recruited from three hospitals in Taiwan to determine the association between esophageal squamous-cell-carcinoma (ESCC) and microsomal epoxide hydrolase (mEH) genotypes at Thy113His and His139Arg. Stratified by their exposures, the His113His genotype was a significant protective factor for ESCC in areca chewers and tobacco smokers. Stratified by His113 polymorphisms, the risk of contracting ESCC for participants with His113His who chewed areca and smoked was >50% less than for those with Thy113Thy. We suggest that the mEH His113His genotype can differentiate the association between smoking, areca chewing, and ESCC.
authors: The Graduate Institute of Dental Science, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
authors: Ying-Chu
authors: YC
authors: Lin
authors: Deng-Chyang
authors: DC
authors: Wu
authors: Jang-Ming
authors: JM
authors: Lee
authors: Hon-Ki
authors: HK
authors: Hsu
authors: Ein-Long
authors: EL
authors: Kao
authors: Chien-Hui
authors: CH
authors: Yang
authors: Ming-Tsang
authors: MT
authors: Wu
mesh_terms: D000328:Adult; D001114:Areca; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000235:genetics*; D004851:Epoxide Hydrolases / Q000235:genetics*; D004938:Esophageal Neoplasms / Q000201:enzymology* / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008861:Microsomes / Q000201:enzymology*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012907:Smoking; D013624:Taiwan
chemical_list: D004851:Epoxide Hydrolases