title: Reduced prevalence of Epstein-Barr virus-related lymphocryptovirus infection in sera from a new world primate.
abstract: The recent discovery of an Epstein-Barr virus (EBV)-related lymphocryptovirus (LCV) naturally infecting common marmosets demonstrated that gamma-1 herpesviruses are not limited to human and Old World nonhuman primate hosts. We developed serologic assays to detect serum antibodies against lytic- and latent-infection marmoset LCV antigens in order to perform the first seroepidemiologic study of LCV infection in New World primates. In three different domestic colonies and in animals recently captured from the wild, we found that the seroprevalence of marmoset LCV infection was not as ubiquitous as with EBV or Old World LCV. These biologic differences in LCV infection of New World versus human and Old World primate hosts correlate with the evolution of the LCV viral gene repertoire.
authors: Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. fwang@rics.bwh.harvard.edu
authors: Mark H
authors: MH
authors: Fogg
authors: Angela
authors: A
authors: Carville
authors: Jennifer
authors: J
authors: Cameron
authors: Carol
authors: C
authors: Quink
authors: Fred
authors: F
authors: Wang
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D002144:Callithrix / Q000097:blood; D036022:Capsid Proteins / Q000235:genetics; D006566:Herpesviridae Infections / Q000453:epidemiology*; D018143:Lymphocryptovirus / Q000235:genetics / Q000276:immunology*; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D016036:Seroepidemiologic Studies; D012698:Serologic Tests / Q000379:methods; D014412:Tumor Virus Infections / Q000453:epidemiology*
chemical_list: D000914:Antibodies, Viral; D036022:Capsid Proteins