title: Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1.
abstract: The C-terminal PDZ ligand of the AMPA receptor GluR1 subunit may be important for expression of CA1 hippocampal long-term potentiation. To test this directly in vivo, we generated a knock-in mouse lacking the last seven residues of GluR1, comprising the PDZ ligand. This deletion did not affect basal GluR1 synaptic localization, basal synaptic transmission, long-term potentiation or long-term depression, indicating that the ligand is not required for CA1 hippocampal synaptic plasticity.
authors: Department of Neuroscience and Howard Hughes Medical Institute, The Johns Hopkins University, Baltimore, Maryland 21205, USA.
authors: Chong-Hyun
authors: CH
authors: Kim
authors: Kogo
authors: K
authors: Takamiya
authors: Ronald S
authors: RS
authors: Petralia
authors: Rita
authors: R
authors: Sattler
authors: Sandy
authors: S
authors: Yu
authors: Weiguo
authors: W
authors: Zhou
authors: Robert
authors: R
authors: Kalb
authors: Robert
authors: R
authors: Wenthold
authors: Richard
authors: R
authors: Huganir
mesh_terms: D000818:Animals; D006624:Hippocampus / Q000502:physiology*; D008024:Ligands; D017774:Long-Term Potentiation / Q000502:physiology*; D036881:Long-Term Synaptic Depression / Q000502:physiology; D051379:Mice; D008822:Mice, Transgenic; D009473:Neuronal Plasticity / Q000502:physiology; D018091:Receptors, AMPA / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology; D014018:Tissue Distribution
chemical_list: D008024:Ligands; D018091:Receptors, AMPA