Age-related differences in the degree of lipid peroxidation and state of antioxidant protection under the influence of alloxan.
Alloxan-induced hyperglycemia was accompanied by activation of lipid peroxidation processes with different degree of their completeness depending on the age of experimental animals. Lipid peroxidation in young animals mainly resulted in the formation of end-products, while in adult animals the initial stage of oxidation prevailed. Alloxan inhibited the enzymatic and nonenzymatic systems of antioxidant protection, which impaired adaptation and caused oxidative stress.
Yan'kova
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Vladivostok Branch, Far-Eastern Research Center for Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences, Institute of Medical Climatology and Rehabilitative Therapy. jankova_nch@list.ru
Gvozdenko
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TA
D000375:Aging; D000496:Alloxan / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D006943:Hyperglycemia / Q000139:chemically induced; D006949:Hyperlipidemias / Q000139:chemically induced; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000032:analysis / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D008315:Malondialdehyde; D000496:Alloxan