title: Predictive factors of glucocorticosteroid treatment failure in severe acute idiopathic colitis.
abstract: BACKGROUND
  The purpose of our study was to determine clinical, biological or endoscopic factors that could predict glucocorticosteroid treatment failure in acute colitis.
  
  
  METHODS
  Fifty-four Tunisian Caucasian patients with acute idiopathic colitis (ulcerative colitis in 53 patients, Crohn's colitis in 1 patient) have been evaluated. Non-therapeutic response was defined as over 6 bowel movements per day, blood visible to the naked eye in stools on the fifth day after admission or the development of a complication inducing a resort to surgery. Predictive factors were assessed using bivariate and multivariate analysis.
  
  
  RESULTS
  Thirty-nine patients (72.2%) had no medical response. In univariate analysis, predictive factors of therapeutic failure were: male sex, tobacco, previous history of colitis attacks, bowel movements per day over seven at admission and on day three, and pulse rate over 90/mn, temperature over 38 degrees C, systolic blood pressure below 11 on day 3 and on day 5 after admission. In multivariate analysis, bowel movements over seven per day on day 3 of hospitalization and male sex independently predicted a failure of glucorticosteroid treatment.
  
  
  CONCLUSIONS
  Bowel movements per day over seven on day 3 of hospitalization and male sex were the independently predictive factors of failure of glucocorticosteroid treatment.
authors: Service de Gastroentérologie, Hôpital Universitaire Sahloul, Sousse, Tunisia. hela.elloumi@laposte.net
authors: H
authors: H
authors: Elloumi
authors: A
authors: A
authors: Ben Abdelaziz
authors: F
authors: F
authors: Derbel
authors: A
authors: A
authors: Jmaa
authors: Y
authors: Y
authors: Lassoued
authors: D
authors: D
authors: Arfaoui
authors: A
authors: A
authors: Ben Ali
authors: R
authors: R
authors: Letaief
authors: R Bel Hadj
authors: RB
authors: Hamida
authors: H
authors: H
authors: Ghannem
authors: S
authors: S
authors: Ajmi
mesh_terms: D000208:Acute Disease; D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D015331:Cohort Studies; D003093:Colitis, Ulcerative / Q000175:diagnosis* / Q000188:drug therapy*; D003424:Crohn Disease / Q000175:diagnosis / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007262:Infusions, Intravenous; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011336:Probability; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids