title: Organotypic cultures as tools for functional screening in the CNS.
abstract: A major challenge for the pharmaceutical industry is the development of relevant model systems in which knowledge gained from high-throughput, genomic and proteomic approaches can be integrated to study function. Animal models are still the main choice for such studies but over the past few years powerful new in vitro systems have begun to emerge as useful tools to study function. Organotypic cultures made from slices of explanted tissue represent a complex multi-cellular in vitro environment with the potential to assess biological function and are uniquely placed to act as an important link between high-throughput approaches and animal models.
authors: Capsant Neurotechnologies Ltd., Biomedical Sciences Building, Southampton SO16 7PX, UK. Lars@capsant.com
authors: Lars
authors: L
authors: Sundstrom
authors: Barclay
authors: B
authors: Morrison
authors: Mark
authors: M
authors: Bradley
authors: Ashley
authors: A
authors: Pringle
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000254:growth & development* / Q000502:physiology*; D004345:Drug Industry / Q000379:methods / Q000639:trends; D013678:Technology, Pharmaceutical / Q000379:methods / Q000639:trends; D046509:Tissue Culture Techniques / Q000379:methods* / Q000639:trends