title: Acebutolol-induced subacute cutaneous lupus erythematosus.
abstract: Beta-blocking medications are rarely associated with drug-induced lupus erythematosus syndrome and have never been incriminated as a cause of subacute lupus erythematosus (SCLE). We present herein the first case of SCLE induced by acebutolol. A 57-year-old woman presented with a 1-month history of a cutaneous eruption of the photo-exposed areas. One month ago, the patient had started a treatment with oral acebutolol to cure a hypertension of 1-year evolution. Physical examination revealed erythematous scaly annular plaques, involving the face, arms and trunk. Immunologic serology findings revealed a positive titer of antinuclear antibodies up to 1/1,280 with positivity of antihistone and Ro/SSA antibodies. Acebutolol was stopped, and the lesions cleared completely 4 months later. Literature data, along with our case, suggest a link between acebutolol therapy and the onset of a lupus syndrome. Although this is the first report of acebutolol-induced SCLE, we should be aware of this occurrence, and avoidance of acebutolol is recommended in patients with stigmata of lupus erythematosus.
authors: Dermatology Department, Habib Thameur Hospital, Tunis, Tunisia. fenniche.samy@planet.tn
authors: S
authors: S
authors: Fenniche
authors: A
authors: A
authors: Dhaoui
authors: F Ben
authors: FB
authors: Ammar
authors: R
authors: R
authors: Benmously
authors: H
authors: H
authors: Marrak
authors: I
authors: I
authors: Mokhtar
mesh_terms: D000070:Acebutolol / Q000009:adverse effects*; D000319:Adrenergic beta-Antagonists / Q000009:adverse effects*; D000974:Antibodies, Antinuclear / Q000032:analysis; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008178:Lupus Erythematosus, Cutaneous / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D008875:Middle Aged
chemical_list: D000319:Adrenergic beta-Antagonists; D000974:Antibodies, Antinuclear; C035356:SS-A antibodies; D000070:Acebutolol