title: Radiological evidence of early cerebral microvascular disease in young children with Fabry disease.
abstract: We report on 2 children with Fabry disease who had radiologic evidence of microvascular central nervous system involvement despite the clinical absence of renal, cardiac, or cerebral manifestations. This suggests that treatment with enzyme replacement therapy may be necessary early in the disease to avoid irreversible complications.
authors: Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA.
authors: Mario A
authors: MA
authors: Cabrera-Salazar
authors: Erin
authors: E
authors: O'Rourke
authors: Gustavo
authors: G
authors: Charria-Ortiz
authors: John A
authors: JA
authors: Barranger
mesh_terms: D002561:Cerebrovascular Disorders / Q000473:pathology*; D002648:Child; D000795:Fabry Disease / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008833:Microcirculation