Correlation of interictal spike-wave with thalamic glucose metabolism in juvenile myoclonic epilepsy.
The purpose of this study is to define metabolic correlates of generalized spike-wave discharges in juvenile myoclonic epilepsy. We investigated the alterations in glucose metabolism and possible correlations between the interictal epileptiform discharges and regional metabolism in patients with juvenile myoclonic epilepsy using a combined positron emission tomography/electroencephalography method. We found that the thalamic metabolism is slightly increased interictally in the patient group compared with controls. We also observed significant positive correlations between the amount of spike-wave activity and thalamic metabolism. Our results provide evidence that the thalamus has an important role in the generation of spontaneous generalized spike-wave discharges in juvenile myoclonic epilepsy.
Kim
Ji Hyun
JH
Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Im
Ki Chun
KC
Kim
Jae Seung
JS
Lee
Sang-Ahm
SA
Kang
Joong Koo
JK
D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D003710:Demography; D004569:Electroencephalography / Q000379:methods; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism; D007839:Functional Laterality; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D020190:Myoclonic Epilepsy, Juvenile / Q000378:metabolism* / Q000503:physiopathology; D049268:Positron-Emission Tomography / Q000379:methods; D013223:Statistics as Topic; D013788:Thalamus / Q000378:metabolism* / Q000503:physiopathology
D019788:Fluorodeoxyglucose F18; D005947:Glucose