title: Oxidative stress in the fetal circulation does not depend on mode of delivery.
abstract: OBJECTIVE
  We tested whether neonates are subject to oxidative stress by comparing the susceptibility of umbilical blood lipids with copper-induced peroxidation.
  
  
  METHODS
  Umbilical arterial and venous blood samples were drawn from 32 pregnant women who delivered by elective cesarean section (CS) and from 32 pregnant women who delivered by spontaneous vaginal delivery (SVD) in a tertiary care center. Oxidative stress was evaluated by spectrophotometric monitoring of copper-induced peroxidation of serum samples.
  
  
  RESULTS
  The lag preceding lipid peroxidation in umbilical arterial blood was shorter than the lag in umbilical venous blood, irrespective of mode of delivery (14.0+/-1.8 vs 50.6+/-8.25 min, P=.0004 in SVD group; 17.7+/-1.6 vs 39.2+/-7.6 min, P=.006 in CS group).
  
  
  CONCLUSIONS
  Umbilical arterial lipids are more susceptible to peroxidation than umbilical venous lipids, indicating high oxidative stress in the fetal circulation irrespective of mode of delivery.
authors: Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, and Department of Obstetrics and Gynecology, Lis Maternity Hospital, Israel.
authors: Itay
authors: I
authors: Fogel
authors: Ilya
authors: I
authors: Pinchuk
authors: Michael J
authors: MJ
authors: Kupferminc
authors: Dov
authors: D
authors: Lichtenberg
authors: Ofer
authors: O
authors: Fainaru
mesh_terms: D000328:Adult; D002585:Cesarean Section; D003300:Copper / Q000494:pharmacology; D036861:Delivery, Obstetric / Q000379:methods*; D005260:Female; D005312:Fetal Blood / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D007743:Labor, Obstetric / Q000502:physiology; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D018384:Oxidative Stress; D011247:Pregnancy; D013997:Time Factors; D014469:Umbilical Arteries; D014471:Umbilical Veins
chemical_list: D008055:Lipids; D003300:Copper