title: Nutritional and technological behavior of stabilized iron-gluconate in wheat flour.
abstract: Food fortification has been shown to be an effective strategy to overcome iron malnutrition. When a new iron compound is developed for this purpose, it must be evaluated from a nutritional and technological point of view before adding it into foods. In this way, we have evaluated ferrous gluconate stabilized by glycine as a new iron source to be used in wheat flour fortification. We performed biological studies in rats as well as sensory perceptions by human subjects in wheat flour fortified with this iron source. The productions of pentane as a rancidity indicator as well as the change of the sensorial properties of the biscuits made with stabilized ferrous gluconate-fortified wheat flour were negligible. Iron absorption in water from this iron source was similar to the reference standard ferrous sulfate. Nevertheless, because of the phytic acid content, iron absorption from fortified wheat flour decrease 40% for both iron sources. The addition of zinc from different sources did not modify iron absorption from ferrous sulfate and stabilized ferrous gluconate in water and wheat flour. The iron absorption mechanism as well as the biodistribution studies demonstrate that the biological behavior of this iron source does not differ significantly from the reference standard. These results demonstrate that the iron source under study has adequate properties to be used in wheat flour fortification. Nevertheless, more research is needed before considering this iron source for its massive use in food fortification.
authors: Stable Isotope Laboratory Applied to Biology and Medicine and Radioisotope Laboratory, Physics Department, University of Buenos Aires, Junín 956, 1113-Ciudad de Buenos Aires, Argentina.
authors: J
authors: J
authors: Salgueiro
authors: A
authors: A
authors: Lysionek
authors: A
authors: A
authors: Ridolfi
authors: M
authors: M
authors: Zubillaga
authors: A
authors: A
authors: Barrado
authors: M
authors: M
authors: Martinez-Sarrasague
authors: C
authors: C
authors: Goldman
authors: J
authors: J
authors: Boccio
mesh_terms: D000818:Animals; D001682:Biological Availability; D002845:Chromatography; D005260:Female; D005290:Ferric Compounds / Q000737:chemistry / Q000494:pharmacology*; D005433:Flour; D005527:Food, Fortified; D005942:Gluconates / Q000737:chemistry; D005998:Glycine / Q000737:chemistry; D007501:Iron / Q000378:metabolism; D007504:Iron Radioisotopes / Q000378:metabolism*; D019266:Iron, Dietary; D008297:Male; D010420:Pentanes / Q000737:chemistry; D010465:Perception; D010833:Phytic Acid / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012015:Reference Standards; D013649:Taste; D013997:Time Factors; D014908:Triticum / Q000378:metabolism*; D019287:Zinc Sulfate / Q000737:chemistry
chemical_list: D005290:Ferric Compounds; D005942:Gluconates; D007504:Iron Radioisotopes; D019266:Iron, Dietary; D010420:Pentanes; C033353:pentane; D019287:Zinc Sulfate; D010833:Phytic Acid; D007501:Iron; C030691:gluconic acid; D005998:Glycine; C035552:ferric gluconate