title: Corticobasal degeneration and Parkinson's disease assessed by HmPaO SPECT: the utility of factorial discriminant analysis.
abstract: The diagnosis of corticobasal degeneration (CBD) is difficult despite the existence of some typical clinical features. Single photon emission computerized tomography (SPECT) in CBD presents an original pattern (with asymmetric hypoperfusion in pre- and retrorolandic regions) that could facilitate the differential diagnosis of CBD relative to the other degenerative parkinsonian syndromes. The objective of our study was to compare the regional cerebral blood flow measurements studied by SPECT in both CBD and Parkinson's disease (PD) using a multivariate procedure. Twenty-one patients with probable CBD and 20 patients with probable PD underwent brain (99m)Tc HmPaO SPECT. We used factorial discriminant analysis (FDA) to study the relative fixation of 26 regions of interest (ROIs) drawn on two transverse slices, together with the asymmetry indexes of 13 pairs of ROIs. FDA performed using the full set of parameters classified all the patients correctly. In order to classify the patients more easily, a predictive score using a selection of parameters was established. The most discriminating ROIs were the temporoinsular, temporoparietal, and frontal medial regions. We believe that this semiautomatic classification may be a precious tool for reinforcing the current clinical differential diagnosis of CBD and PD.
authors: Department of Neurology, Regional and University Hospital, Lille, France.
authors: Alexandre
authors: A
authors: Kreisler
authors: Luc
authors: L
authors: Defebvre
authors: Pascal
authors: P
authors: Lecouffe
authors: Alain
authors: A
authors: Duhamel
authors: Pierre
authors: P
authors: Charpentier
authors: Marc
authors: M
authors: Steinling
authors: Alain
authors: A
authors: Destée
mesh_terms: D000368:Aged; D001480:Basal Ganglia Diseases / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation; D016002:Discriminant Analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010300:Parkinson Disease / Q000000981:diagnostic imaging*; D018709:Statistics, Nonparametric; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019690:Technetium Tc 99m Exametazime