[Effects of Anxin Granules on blood lipid and ultrastructure of aorta in rabbits with dyslipidemia].
OBJECTIVE
To study the effects of Anxin Granules on dyslipidemia in rabbits caused by high fat plus high cholesterol diet.


METHODS
Thirty-two healthy New Zealand male white rabbits were randomly divided into 4 groups: normal control group, untreated group, Zhibituo Tablet-treated group and Anxin Granule-treated group. Rabbits in the normal control group were fed with regular chow, while rabbits in the other three groups were fed with high fat plus high cholesterol diet. Zhibituo Tablets and Anxin Granules were administered to the rabbits in Zhibituo Tablet-treated group and Anxin Granule-treated group at a daily oral dose respectively. At the end of the 10th week, the levels of serum total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein A(1) (ApoA1) and apolipoprotein B (ApoB) were tested in each group, and the ultrastructures of the aorta were also observed by an electron microscope.


RESULTS
Anxin Granules could reduce the levels of TC, TG, LDL-C and ApoB. The results observed by electron microscope showed that, as compared with the untreated group and the Zhibituo Tablet-treated group, the atherosclerosis of aorta in the Anxin Granule-treated group was lighter. And it was found that there were few lipid droplet vacuoles in cytoplasm of the endothelial cells, and various cell organs and elastic membrane were existed, but no lipid droplet vacuoles in cytoplasm of the medial smooth muscle cells.


CONCLUSIONS
Anxin Granules can regulate the metabolism of blood lipid and inhibit the formation of atherosclerosis caused by hyperlipidemia in rabbits.
Fang
Xian-Ming
XM
Department of Cardiovascular Internal Medicine, Ruikang Hospital, Guangxi College of Traditional Chinese Medicine, Nanning, Guangxi Province 530011,China. fxm621@126.com
Yuan
Ying
Y
Wu
Yun-Hong
YH
Yin
Xue-Man
XM
D000818:Animals; D001013:Aorta, Thoracic / Q000648:ultrastructure*; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000473:pathology; D008055:Lipids / Q000097:blood*; D008297:Male; D008517:Phytotherapy; D011817:Rabbits; D011897:Random Allocation; D014280:Triglycerides / Q000097:blood
D008078:Cholesterol, LDL; D004365:Drugs, Chinese Herbal; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol