title: A comparison of the efficacy of two commercial Aujeszky's disease vaccines with glycoprotein-I deletion in pigs.
abstract: Two commercial Aujeszky's disease vaccines, a modified killed vaccine and a sub-unit vaccine, both carrying a deletion of glycoprotein-I, were evaluated in pigs. Each vaccine was administered to two groups of four pigs, twice at 4-week intervals, with two pigs held as unvaccinated controls. All pigs were challenged with a New Zealand field isolate of Aujeszky's disease virus 3 weeks after the second vaccination. The results indicate that the sub-unit vaccine was able to protect pigs against clinical Aujeszky's disease much better than the pigs vaccinated with the modified killed vaccine when challenged with a virulent virus. However, the amount and the duration of virulent virus excretion following challenge was greater with the sub-unit vaccine than the modified killed vaccine. Pigs vaccinated with the sub-unit vaccine were shown to be latently infected following challenge. Latent infection was demonstrated by excretion of Aujeszky's disease virus from the nasal cavity after dexamethasone treatment and seroconversion of a sentinel in contact pigs to Aujeszky's disease virus.
authors: MAF Quality Management, Central Animal Health Laboratory, Wallaceville, P.O. Box 40063, Upper Hutt, New Zealand.
authors: M J
authors: MJ
authors: Motha
authors: G W
authors: GW
authors: Horner
authors: K M
authors: KM
authors: Tham
authors: J C
authors: JC
authors: Ralston