A comparative analysis of the total syntheses of the amphidinolide T natural products.
In this article we compare and contrast the strategies and tactics used in the syntheses of the amphidinolide T family of natural products that have been reported by Fürstner, Ghosh and ourselves. Similar approaches to the trisubstituted THF ring present in the targets are utilized in all of the syntheses, but each strategy showcases a different means of macrocyclization.
Colby
Elizabeth A
EA
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Jamison
Timothy F
TF
D001688:Biological Products / Q000138:chemical synthesis*; D018942:Macrolides / Q000138:chemical synthesis*; D000097442:Amphidinolides
D001688:Biological Products; D018942:Macrolides; C414522:amphidinolide T; D000097442:Amphidinolides