Prognostic importance of secondary pulmonary hypertension after acute myocardial infarction.
We studied 536 patients with acute myocardial infarction and echocardiographic assessment of left ventricular systolic and diastolic function and measurement of right ventricular systolic pressure. On multivariable analysis, the grade of diastolic function, mitral regurgitation severity, age, and wall motion score index were independent predictors of right ventricular systolic pressure, and an increase in right ventricular systolic pressure was independently predictive of mortality (hazard ratio 1.22 per 10 mm Hg, p <0.0001), after adjustment for conventional risk factors and left ventricular function.
Møller
Jacob E
JE
Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Hillis
Graham S
GS
Oh
Jae K
JK
Pellikka
Patricia A
PA
D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D015331:Cohort Studies; D015897:Comorbidity; D017548:Echocardiography, Transesophageal; D005260:Female; D006334:Heart Function Tests; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis* / Q000453:epidemiology* / Q000628:therapy; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000453:epidemiology* / Q000628:therapy; D011336:Probability; D011379:Prognosis; D016016:Proportional Hazards Models; D011669:Pulmonary Wedge Pressure; D012189:Retrospective Studies; D018570:Risk Assessment; D017678:Sex Distribution; D016019:Survival Analysis; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging; D020257:Ventricular Remodeling / Q000502:physiology