title: The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease.
abstract: Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.
authors: Department of Parasite Genomics, Institute for Genomic Research, Rockville, MD 20850, USA. nelsayed@tigr.org
authors: Najib M
authors: NM
authors: El-Sayed
authors: Peter J
authors: PJ
authors: Myler
authors: Daniella C
authors: DC
authors: Bartholomeu
authors: Daniel
authors: D
authors: Nilsson
authors: Gautam
authors: G
authors: Aggarwal
authors: Anh-Nhi
authors: AN
authors: Tran
authors: Elodie
authors: E
authors: Ghedin
authors: Elizabeth A
authors: EA
authors: Worthey
authors: Arthur L
authors: AL
authors: Delcher
authors: Gaëlle
authors: G
authors: Blandin
authors: Scott J
authors: SJ
authors: Westenberger
authors: Elisabet
authors: E
authors: Caler
authors: Gustavo C
authors: GC
authors: Cerqueira
authors: Carole
authors: C
authors: Branche
authors: Brian
authors: B
authors: Haas
authors: Atashi
authors: A
authors: Anupama
authors: Erik
authors: E
authors: Arner
authors: Lena
authors: L
authors: Aslund
authors: Philip
authors: P
authors: Attipoe
authors: Esteban
authors: E
authors: Bontempi
authors: Frédéric
authors: F
authors: Bringaud
authors: Peter
authors: P
authors: Burton
authors: Eithon
authors: E
authors: Cadag
authors: David A
authors: DA
authors: Campbell
authors: Mark
authors: M
authors: Carrington
authors: Jonathan
authors: J
authors: Crabtree
authors: Hamid
authors: H
authors: Darban
authors: Jose Franco
authors: JF
authors: da Silveira
authors: Pieter
authors: P
authors: de Jong
authors: Kimberly
authors: K
authors: Edwards
authors: Paul T
authors: PT
authors: Englund
authors: Gholam
authors: G
authors: Fazelina
authors: Tamara
authors: T
authors: Feldblyum
authors: Marcela
authors: M
authors: Ferella
authors: Alberto Carlos
authors: AC
authors: Frasch
authors: Keith
authors: K
authors: Gull
authors: David
authors: D
authors: Horn
authors: Lihua
authors: L
authors: Hou
authors: Yiting
authors: Y
authors: Huang
authors: Ellen
authors: E
authors: Kindlund
authors: Michele
authors: M
authors: Klingbeil
authors: Sindy
authors: S
authors: Kluge
authors: Hean
authors: H
authors: Koo
authors: Daniela
authors: D
authors: Lacerda
authors: Mariano J
authors: MJ
authors: Levin
authors: Hernan
authors: H
authors: Lorenzi
authors: Tin
authors: T
authors: Louie
authors: Carlos Renato
authors: CR
authors: Machado
authors: Richard
authors: R
authors: McCulloch
authors: Alan
authors: A
authors: McKenna
authors: Yumi
authors: Y
authors: Mizuno
authors: Jeremy C
authors: JC
authors: Mottram
authors: Siri
authors: S
authors: Nelson
authors: Stephen
authors: S
authors: Ochaya
authors: Kazutoyo
authors: K
authors: Osoegawa
authors: Grace
authors: G
authors: Pai
authors: Marilyn
authors: M
authors: Parsons
authors: Martin
authors: M
authors: Pentony
authors: Ulf
authors: U
authors: Pettersson
authors: Mihai
authors: M
authors: Pop
authors: Jose Luis
authors: JL
authors: Ramirez
authors: Joel
authors: J
authors: Rinta
authors: Laura
authors: L
authors: Robertson
authors: Steven L
authors: SL
authors: Salzberg
authors: Daniel O
authors: DO
authors: Sanchez
authors: Amber
authors: A
authors: Seyler
authors: Reuben
authors: R
authors: Sharma
authors: Jyoti
authors: J
authors: Shetty
authors: Anjana J
authors: AJ
authors: Simpson
authors: Ellen
authors: E
authors: Sisk
authors: Martti T
authors: MT
authors: Tammi
authors: Rick
authors: R
authors: Tarleton
authors: Santuza
authors: S
authors: Teixeira
authors: Susan
authors: S
authors: Van Aken
authors: Christy
authors: C
authors: Vogt
authors: Pauline N
authors: PN
authors: Ward
authors: Bill
authors: B
authors: Wickstead
authors: Jennifer
authors: J
authors: Wortman
authors: Owen
authors: O
authors: White
authors: Claire M
authors: CM
authors: Fraser
authors: Kenneth D
authors: KD
authors: Stuart
authors: Björn
authors: B
authors: Andersson
mesh_terms: D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy / Q000469:parasitology; D004260:DNA Repair; D004261:DNA Replication; D004272:DNA, Mitochondrial / Q000235:genetics; D016054:DNA, Protozoan / Q000235:genetics; D017125:Genes, Protozoan; D018503:Genome, Protozoan; D006801:Humans; D008540:Meiosis; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D005810:Multigene Family; D015800:Protozoan Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D011995:Recombination, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D018626:Retroelements; D017422:Sequence Analysis, DNA; D015398:Signal Transduction; D016615:Telomere / Q000235:genetics; D014344:Trypanocidal Agents / Q000494:pharmacology / Q000627:therapeutic use; D014349:Trypanosoma cruzi / Q000737:chemistry / Q000235:genetics* / Q000502:physiology
chemical_list: D004272:DNA, Mitochondrial; D016054:DNA, Protozoan; D008565:Membrane Proteins; D015800:Protozoan Proteins; D018626:Retroelements; D014344:Trypanocidal Agents