Relationship of extent and nature of dysfunctional myocardium to brain natriuretic peptide in patients with ischemic left ventricular dysfunction.
We studied the relationship between brain natriuretic peptide (BNP) levels and viable myocardium and ischemic myocardium, regional scar and regional contractile function. Fifty-nine patients underwent dobutamine echocardiography and magnetic resonance imaging and resting BNP levels were determined. By magnetic resonance imaging, total extent of dysfunctional myocardium correlated strongest with BNP (r = 0.60, p < 0.0001). The extent of scar, viability and ischemia also correlated. At dobutamine echocardiography, a composite of dysfunctional and ischemic myocardium was the strongest correlate of BNP (r = 0.48, p < 0.0001), with less strong correlations by global parameters. The extent of dysfunctional myocardium, rather than its nature determines BNP levels.
Nelson
Charles A
CA
Department of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia.
Case
Colin
C
McCrohon
Jane
J
Marwick
Thomas H
TH
D000328:Adult; D000367:Age Factors; D000368:Aged; D002306:Cardiac Volume; D003404:Creatinine / Q000097:blood; D025401:Echocardiography, Stress; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009200:Myocardial Contraction; D017202:Myocardial Ischemia / Q000097:blood* / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000473:pathology
D020097:Natriuretic Peptide, Brain; D003404:Creatinine