Resting anterior cingulate activity and abnormal responses to errors in subjects with elevated depressive symptoms: a 128-channel EEG study.
Depression has been associated with dysfunctional executive functions and abnormal activity within the anterior cingulate cortex (ACC), a region critically involved in action regulation. Prior research invites the possibility that executive deficits in depression may arise from abnormal responses to negative feedback or errors, but the underlying neural substrates remain unknown. We hypothesized that abnormal reactions to error would be associated with dysfunctional rostral ACC activity, a region previously implicated in error detection and evaluation of the emotional significance of events. To test this hypothesis, subjects with low and high Beck Depression Inventory (BDI) scores performed an Eriksen Flanker task. To assess whether tonic activity within the rostral ACC predicted post-error adjustments, 128-channel resting EEG data were collected before the task and analyzed with low-resolution electromagnetic tomography (LORETA) using a region-of-interest approach. High BDI subjects were uniquely characterized by significantly lower accuracy after incorrect than correct trials. Mirroring the behavioral findings, high BDI subjects had significantly reduced pretask gamma (36.5-44 Hz) current density within the affective (rostral; BA24, BA25, BA32) but not cognitive (dorsal; BA24', BA32') ACC subdivision. For low, but not high, BDI subjects pretask gamma within the affective ACC subdivision predicted post-error adjustments even after controlling for activity within the cognitive ACC subdivision. Abnormal responses to errors may thus arise due to lower activity within regions subserving affective and/or motivational responses to salient cues. Because rostral ACC regions have been implicated in treatment response in depression, our findings provide initial insight into putative mechanisms fostering treatment response.
Pizzagalli
Diego A
DA
Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA. dap@wjh.harvard.edu
Peccoralo
Lauren A
LA
Davidson
Richard J
RJ
Cohen
Jonathan D
JD
D000293:Adolescent; D000328:Adult; D000339:Affect / Q000502:physiology; D001007:Anxiety / Q000503:physiopathology; D001931:Brain Mapping; D003071:Cognition / Q000502:physiology*; D003463:Cues; D003866:Depressive Disorder / Q000503:physiopathology*; D004569:Electroencephalography; D004644:Emotions / Q000502:physiology*; D005260:Female; D006179:Gyrus Cinguli / Q000033:anatomy & histology / Q000502:physiology*; D006801:Humans; D015225:Magnetoencephalography; D019964:Mood Disorders / Q000503:physiopathology; D009042:Motivation; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000502:physiology