title: Periodontal treatment in severe aplastic anemia.
abstract: BACKGROUND
  Aplastic anemia (AA) is a rare hematologic disease characterized by hypo-cellular bone marrow. The clinical features include fatigue, increased bruising, and gingival bleeding caused by anemia, leukopenia, and thrombocytopenia. A patient with AA is at high risk for infection because of leukopenia. The risk of systemic infection is especially high in AA patients with severe local infections, including periodontitis. Accordingly, periodontal treatment should include antibiotic prophylaxis to reduce the risk of systemic infection. However, treatment of periodontitis in the AA patient is significantly complicated by the bleeding disorder. We present a case report of the successful periodontal treatment of an AA patient with spontaneous gingival bleeding.
  
  
  METHODS
  The patient was closely monitored for platelet and neutrophil counts before every treatment. The patient's platelet count was always under 10,000/microl. Therefore, it was necessary to increase platelet counts to over 25,000/microl by transfusion, after which subgingival scaling with anesthesia was performed. When the neutrophil count was less than 2,000/microl, local minocycline chemotherapy was applied to the pockets. Periodontal infection was monitored by detection of bacterial DNA and measurement of serum immunoglobulin (Ig) G titer against periodontal bacteria.
  
  
  RESULTS
  Following the physical and chemical treatment, the gingival appearance improved dramatically and the spontaneous gingival bleeding disappeared. Moreover, the IgG titer against periodontal bacteria decreased to normal range and specific periodontal pathogens were no longer detectable in the tested pockets.
  
  
  CONCLUSIONS
  We believe that the treatment strategy in the present report provides new sight into treatment planning for severely medically compromised patients.
authors: Department of Pathophysiology/Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8525, Japan.
authors: Kosuke
authors: K
authors: Oyaizu
authors: Fumi
authors: F
authors: Mineshiba
authors: Junji
authors: J
authors: Mineshiba
authors: Hirokazu
authors: H
authors: Takaya
authors: Fusanori
authors: F
authors: Nishimura
authors: Ichiro
authors: I
authors: Tanimoto
authors: Hideo
authors: H
authors: Arai
authors: Shogo
authors: S
authors: Takashiba
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic / Q000097:blood / Q000150:complications; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000097:blood; D016866:Bacteroidaceae Infections / Q000150:complications / Q000188:drug therapy; D017742:Dental Care for Chronically Ill; D012534:Dental Scaling; D005884:Gingival Hemorrhage / Q000209:etiology*; D006801:Humans; D008297:Male; D008911:Minocycline / Q000627:therapeutic use; D010518:Periodontitis / Q000097:blood / Q000150:complications* / Q000188:drug therapy* / Q000382:microbiology; D017713:Platelet Transfusion; D018713:Prevotella intermedia / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D008911:Minocycline