Effects of bradysole and dibasole on cerebral bloodflow under experimental conditions.
Bradysole (1 mg/kg intravenously) induced a moderate increase in cerebral bloodflow and a minor decrease in systemic blood pressure in narcotized rats. These effects were less pronounced compared to the effects of dibasole (bradysole structural analog) in the same dose.
Galenko-Yaroshevskii
P A
PA
Kuban State Medical Academy, and Krasnodar Territorial Medical Research Center, Krasnodar.
Turovaya
A Yu
AY
Uvarov
A V
AV
Ivashev
M N
MN
Arl't
A V
AV
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D008297:Male; D018377:Neurotransmitter Agents / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013438:Sulfhydryl Compounds / Q000494:pharmacology; D013997:Time Factors
D001562:Benzimidazoles; D018377:Neurotransmitter Agents; D013438:Sulfhydryl Compounds; C505607:bradysole; C004453:bendazole