Environmental reduplicative paramnesia in a case of atypical Alzheimer's disease.
A 79-year-old patient with neuropathologically confirmed Alzheimer's disease (AD) presented with a selective environmental reduplicative paramnesia (RP), the belief that one or more environments exist simultaneously in two or more physical locations. Clinical presentation and neuropathological examination revealed an atypical form of AD. High neurofibrillary tangle densities were observed in the frontal and temporal association cortex, whereas the parietal and entorhinal cortex, as well as the hippocampus, were nearly spared. These findings are compared to those reported in frontal and frontotemporal variants of AD and discussed in the light of current anatomoclinical models for environmental RP.
von Gunten
Armin
A
Service Universitaire de Psychiatrie de l' Age Avancé, Centre Hospitalier Universitaire Vandois, Lausanne, Switzerland. armin.von-gunten@inst.hospvd.ch
Miklossy
Judit
J
Suvà
Mario-Luca
ML
Hof
Patrick R
PR
Glannakopoulos
Panteleimon
P
D000203:Activities of Daily Living; D000368:Aged; D000544:Alzheimer Disease / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D000647:Amnesia / Q000209:etiology*; D001288:Attention / Q000502:physiology; D002540:Cerebral Cortex / Q000473:pathology; D003071:Cognition / Q000502:physiology; D004644:Emotions; D004777:Environment; D005500:Follow-Up Studies; D007839:Functional Laterality; D006801:Humans; D007360:Intelligence / Q000502:physiology; D007802:Language; D008297:Male; D016874:Neurofibrillary Tangles / Q000473:pathology; D009949:Orientation / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology; D012563:Schizophrenia, Paranoid / Q000209:etiology*; D014057:Tomography, X-Ray Computed / Q000379:methods; D014796:Visual Perception / Q000502:physiology