title: Nitrite/nitrate (NOx) and zinc concentrations in influenza-associated encephalopathy in children with different sequela.
abstract: NOx (NO2 and NO3) in CSF obtained from 22 patients with influenza-associated encephalopathy were higher than those of a control group. Within the different prognosis, there were no significant differences in NOx levels. By analyzing the serum obtained from patients infected with influenza, including encephalopathy, with others, the serum zinc levels did show marked differences between them. Four out of eleven patients with influenza-associated encephalopathy showed low zinc levels below the normal range. However, there were no significant differences in the zinc levels between the group with sequela and without sequela. These results indicate that the increase of NOx levels detected in influenza-associated encephalopathy relates to the low zinc levels, and both low molecules might play an important role for the cause of encephalopathy.
authors: Department of Paediatrics, Tokyo Medical University, Tokyo, Japan. hisashi@tokyo-med.ac.jp
authors: Hisashi
authors: H
authors: Kawashima
authors: Masahiro
authors: M
authors: Amaha
authors: Hiroaki
authors: H
authors: Ioi
authors: Gaku
authors: G
authors: Yamanaka
authors: Yasuyo
authors: Y
authors: Kashiwagi
authors: Masato
authors: M
authors: Sasamoto
authors: Kouji
authors: K
authors: Takekuma
authors: Akinori
authors: A
authors: Hoshika
authors: Yasuo
authors: Y
authors: Watanabe
mesh_terms: D001925:Brain Damage, Chronic / Q000134:cerebrospinal fluid* / Q000209:etiology* / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007223:Infant; D007251:Influenza, Human / Q000134:cerebrospinal fluid* / Q000150:complications* / Q000401:mortality; D008297:Male; D009566:Nitrates / Q000134:cerebrospinal fluid*; D009573:Nitrites / Q000134:cerebrospinal fluid*; D013056:Spectrophotometry, Ultraviolet; D015032:Zinc / Q000097:blood*
chemical_list: D009566:Nitrates; D009573:Nitrites; D015032:Zinc