Micromolar HgCl2 concentrations transitorily duplicate the ATP level in Saccharomyces cerevisiae cells.
Low concentrations of HgCl2 elicited, in Saccharomyces cerevisiae, a transitory increase in the ATP level followed by a decrease of its concentration, until almost disappearance. At 1 microM HgCl2, the increase in ATP lasted for about 30 min, while at 10 microM the increase was only observed in the first 5 min of treatment. The initial burst of ATP was accompanied by a decrease in the level of hexose phosphates, whereas during the decrease of ATP an increase in the inosine and hexose phosphates levels took place. The treatment with HgCl2 inhibited the plasma membrane proton ATPase but not the activities of hexokinase or 6-phosphofructokinase.
Silles
Eduardo
E
Departamento de Bioquímica, Instituto de Investigaciones Biomédicas Alberto Sols UAM/CSIC, Facultad de Medicina, 28029 Madrid, Spain.
Osorio
Hugo
H
Maia
Rita
R
Günther Sillero
María A
MA
Sillero
Antonio
A
D000255:Adenosine Triphosphate / Q000378:metabolism*; D007700:Kinetics; D008627:Mercuric Chloride / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000378:metabolism
D008627:Mercuric Chloride; D000255:Adenosine Triphosphate