title: Diphenhydramine overdose and Brugada sign.
abstract: We report a case of electrocardiographic signature of the Brugada syndrome in a 39-year-old patient with an overdose of diphenhydramine. He was found unconscious and hypotensive. His serum potassium concentration was 8.3 mEq/L and the ECG revealed a coved-type ST-segment elevation in leads V2-V3. These repolarization abnormalities neither normalize with the correction of the hyperkalemia nor with an intravenous infusion of isoproterenol. When he regained consciousness, he was admitted the toxic ingestion of diphenhydramine and progressively the ECG normalized. A negative flecainide test confirmed that the transient ECG abnormalities were the consequence of the drug overdose and ruled out the Brugada syndrome.
authors: Intensive Care Unit, Emergency Department and Arrhythmia Section, Institut Clinic de Malalties Cardiovasculars, IDIBAPS, Hospital Clinic, Spain.
authors: Beatriz
authors: B
authors: López-Barbeito
authors: Meritxell
authors: M
authors: Lluis
authors: Victoria
authors: V
authors: Delgado
authors: Sonia
authors: S
authors: Jiménez
authors: Ernesto
authors: E
authors: Díaz-Infante
authors: Santiago
authors: S
authors: Nogué-Xarau
authors: Josep
authors: J
authors: Brugada
mesh_terms: D000328:Adult; D016757:Death, Sudden, Cardiac / Q000209:etiology; D004155:Diphenhydramine / Q000506:poisoning*; D062787:Drug Overdose; D004562:Electrocardiography; D006801:Humans; D008297:Male; D013406:Suicide, Attempted
chemical_list: D004155:Diphenhydramine