[Antisense oligonucleotides inhibiting ribosomal functions in mycobacteria].
We studied the binding of antisense oligonucleotides with 23S rRNA of mycobacteria and E. coli and identified oligonucleotides with selective affinity to the alpha-sarcin loop region of 23S rRNA of M. tuberculosis and to 70S ribosomes of M. smegmatis. These oligonucleotides proved to selectively inhibit protein synthesis on M. smegmatis ribosomes.
Demchenko
Iu N
IuN
Zenkova
M A
MA
Vlasov
V V
VV
D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D009161:Mycobacterium / Q000187:drug effects* / Q000235:genetics; D009690:Nucleic Acid Conformation; D016376:Oligonucleotides, Antisense / Q000235:genetics / Q000494:pharmacology*; D014176:Protein Biosynthesis / Q000187:drug effects* / Q000235:genetics; D012338:RNA, Ribosomal, 23S / Q000037:antagonists & inhibitors*; D012270:Ribosomes / Q000187:drug effects*
D016376:Oligonucleotides, Antisense; D012338:RNA, Ribosomal, 23S