Antigen-induced suppressor T cells from the skin point of view: suppressor T cells induced through epicutaneous immunization.
The rebirth of interest in suppressor T cells has spawned a vast amount of data that shed light on their biology and role in immune system homeostasis. Since the early studies on the naturally occurring CD4+/CD25+ T regulatory cells, much attention has been focused on ways to induce suppressor T cells in vivo. This review discusses the salient features of the induction of antigen-specific suppressor T cells in a T cell receptor (TCR) transgenic mouse model of experimental allergic encephalomyelitis (EAE) in response to epicutaneous immunization with cognate peptide. We discuss the skin environment as a privileged anatomical site for therapeutic intervention against pro-inflammatory auto-immune disorders using non-invasive approaches for antigen delivery.
Bynoe
Margaret S
MS
Section of Immunobiology, Yale University School of Medicine, and Howard Hughes Medical Institute, 300 Cedar St., New Haven, CT 06520-8011, USA. Margaret.bynoe@yale.edu
Viret
Christophe
C
D000279:Administration, Cutaneous; D000818:Animals; D000941:Antigens / Q000008:administration & dosage / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology; D006801:Humans; D007114:Immunization; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000941:Antigens