title: [The prognostic value of human neuroendocrine clone on colorectal carcinoma].
abstract: OBJECTIVE
  To demonstrate the prognostic value of neuroendocrine clone on colorectal carcinoma.
  
  
  METHODS
  The immunochemistry methods were used to investigate the percent of neuroendocrine carcinoma in 73 human colorectal carcinoma. Retrospective analysis and follow-up were carried out in all patients.
  
  
  RESULTS
  In all 73 cases of colorectal carcinoma, the total percentage of neuroendocrine carcinoma was 17.8%. Neuroendocrine carcinoma included 11 synapse positive, 6 chromogranin positive and 4 both positive. The major factors related to the prevalence of neuroendocrine carcinoma were sex, age, tumor location and Dukes' stage. And the 1-year survival rate of the patients who suffered from neuroendocrine carcinoma is obviously lower than that of other colorectal carcinoma.
  
  
  CONCLUSIONS
  The neuroendocrine carcinoma is a special kind of human colorectal carcinoma, and neuroendocrine clone may be a new marker of the malignant potency. The neuroendocrine clone has its prognostic value and may be a novel therapeutic target.
authors: Department II of Surgery, The People's Hospital, Peking University, Beijing 100044, China.
authors: Xiao-dong
authors: XD
authors: Yang
authors: Shan
authors: S
authors: Wang
authors: Hui-yan
authors: HY
authors: Meng
authors: Ying-jiang
authors: YJ
authors: Ye
authors: You-zhi
authors: YZ
authors: Yu
authors: Ke-wei
authors: KW
authors: Jiang
authors: Shen
authors: S
authors: Yang
authors: Jun
authors: J
authors: Qu
authors: Wei-gang
authors: WG
authors: Fang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018278:Carcinoma, Neuroendocrine / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D002864:Chromogranins / Q000096:biosynthesis; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D016704:Synapsins / Q000096:biosynthesis
chemical_list: D002864:Chromogranins; D016704:Synapsins