[Structure charateristics of mitoxantrone transforsomes].
This study sought to clarify the molecular location and the interaction between mitoxantrone and mitoxantrone transforsomes. The anthraquinone of mitoxantrone, a heterocyclic ring that intercalates in the lipid of bilayer, was determined by UV-spectrophotometry and electron probes scan microscopy. Two aminoethylamino side-chains of the drugs fit to the phosphates of lecithin were determined by 8-value, thus the interaction with lecithin was substantiated. Differential scanning calorimetry confirmed that mitoxantrone has remarkable stabilizing effect on the mitoxantrone transforsomes membrane. The mitoxantrone binds tightly to lecithin. So a high degree of encapsulation efficiency and the sustained-release character of mitoxantrone transforsomes are verified.
Chen
Tong
T
Department of Pharmaceutics Sciences, School of Pharmacy, Sichuan University, Chengdu 610041, China.
Hou
Shixiang
S
Shi
Biqiong
B
Zheng
Yu
Y
Sun
Yiyi
Y
Tian
Yunfei
Y
D000880:Anthraquinones / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D003692:Delayed-Action Preparations / Q000737:chemistry; D054709:Lecithins / Q000737:chemistry; D008942:Mitoxantrone / Q000737:chemistry*; D013053:Spectrophotometry
D000880:Anthraquinones; D003692:Delayed-Action Preparations; D054709:Lecithins; C042834:9,10-anthraquinone; D008942:Mitoxantrone