Characterization of the Vibrio cholerae vceCAB multiple-drug resistance efflux operon in Escherichia coli.
Herein, we identify vceC as a component of a vceCAB operon, which codes for the Vibrio cholerae VceAB multiple-drug resistance (MDR) efflux pump, and vceR, which codes for a transcriptional autoregulatory protein that negatively regulates the expression of the vceCAB operon and is modulated by some of the substrates of this MDR efflux pump.
Woolley
Robin C
RC
Department of Biological Sciences, Texas Tech University, Lubbock, TX 79430, USA.
Vediyappan
Govindsamy
G
Anderson
Matthew
M
Lackey
Melinda
M
Ramasubramanian
Bhagavathi
B
Jiangping
Bai
B
Borisova
Tatyana
T
Colmer
Jane A
JA
Hamood
Abdul N
AN
McVay
Catherine S
CS
Fralick
Joe A
JA
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000096:biosynthesis / Q000235:genetics*; D001425:Bacterial Outer Membrane Proteins / Q000096:biosynthesis / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics; D001665:Binding Sites; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D005809:Genes, Regulator; D016623:Ion Pumps / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics; D016254:Mutagenesis, Insertional; D016366:Open Reading Frames; D009876:Operon; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014734:Vibrio cholerae / Q000235:genetics*
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D016623:Ion Pumps; D008565:Membrane Proteins; C489682:VceA protein, Vibrio cholerae; C500805:VceC protein, Vibrio cholerae; C077169:VceB protein, Vibrio cholerae