title: Pd-Cu bimetallic catalyzed domino cyclization of alpha-allenols followed by a coupling reaction: new sequence leading to functionalized spirolactams.
abstract: A novel regioselective metal-catalyzed spirocyclization of alpha-allenols-cross coupling (Heck, Sonogashira, and Suzuki) reaction sequence, leading to potentially bioactive spirocyclic lactam derivatives has been developed. Precursors for the tandem spirocyclization-coupling reaction, alpha-allenols 2 a-d were obtained starting from alpha-oxolactams 1 a-c via indium-mediated Barbier-type carbonyl-allenylation reaction in aqueous media by using our previously described methodologies.
authors: Departamento de Química Orgánica I, Facultad de Química, Universidad Complutense de Madrid, 28040 Madrid, Spain. alcaideb@quim.ucm.es
authors: Benito
authors: B
authors: Alcaide
authors: Pedro
authors: P
authors: Almendros
authors: Raquel
authors: R
authors: Rodríguez-Acebes