[The pharmacokinetics and pharmacodynamics of intranasal preparation of Panax notoginseng Saponins].
OBJECTIVE
To investigate the pharmacokinetic course of intranasal powders of Panax notoginseng Saponins (PNS) in a rat model and its protective effects against cardio-cerebrovascular diseases administrated in the form of its suspension.


METHODS
After administration, Rgl concentration in the serum was analyzed by HPLC and the absolute bioavailability was calculated. The protective effects against cardia-cerebrovascular diseases were studied on actue myocardial infarction model in rats built by occlusion of left coronary artery and cerebral ischemia-reperfusion model in gerbils built by occlusion of bilateral common carotid artery (CCA).


RESULTS
The in vivo course of Rgl in rats conformed to two-compartment model after intranasal administration of PNS suspension and the absolute bioavailability was 103.56%. The suspension significantly reduced myocardial infarct size induced by occlusion of the left coronary artery, alleviated cerebral edema and the stroke symptoms induced by occlusion of bilateral common carotid artery (CCA). And the effects were dose-dependent, the higher dose, the better effects.


CONCLUSIONS
The results of pharmacokinetics and pharmacodynamics demonstrated that PNS intranasal preparation has a pretty prospect to develop.
Wu
Yun-juan
YJ
Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, China.
Zhu
Xiao-yi
XY
Sha
Xian-yi
XY
Fang
Xiao-ling
XL
D000281:Administration, Intranasal; D000818:Animals; D001682:Biological Availability; D002545:Brain Ischemia / Q000150:complications; D004305:Dose-Response Relationship, Drug; D005260:Female; D005849:Gerbillinae; D036145:Ginsenosides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology*; D008297:Male; D009203:Myocardial Infarction / Q000473:pathology*; D009206:Myocardium / Q000473:pathology; D005894:Panax / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000209:etiology / Q000473:pathology*
D036145:Ginsenosides; C035054:ginsenoside Rg1