Emerging metallo-beta-lactamase-mediated resistances: a summary report from the worldwide SENTRY antimicrobial surveillance program.
The rates of occurrence of metallo-beta-lactamase-mediated resistances in Pseudomonas aeruginosa, Acinetobacter species, and Serratia marcescens, among other gram-negative bacilli, have escalated since 2000, severely limiting treatment options in Asia, Europe, and Latin America to non-beta-lactam antimicrobial classes. Clinical isolates harboring metallo-beta-lactamases have also recently been reported in western Canada and in Texas, signaling the need for development of accurate diagnostic tests by clinical laboratories to detect their presence and for new, and more potent, antimicrobial agents.
Fritsche
Thomas R
TR
Jones Microbiology Institute Laboratories, North Liberty, IA 52317, USA.
Sader
Helio S
HS
Toleman
Mark A
MA
Walsh
Timothy R
TR
Jones
Ronald N
RN
D000150:Acinetobacter / Q000187:drug effects / Q000201:enzymology; D001426:Bacterial Proteins / Q000145:classification; D014943:Global Health; D016905:Gram-Negative Bacterial Infections / Q000453:epidemiology / Q000382:microbiology*; D006801:Humans; D007391:International Cooperation; D011159:Population Surveillance; D015995:Prevalence; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000201:enzymology; D012706:Serratia marcescens / Q000187:drug effects / Q000201:enzymology; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000145:classification / Q000187:drug effects / Q000378:metabolism*
D001426:Bacterial Proteins; D001618:beta-Lactamases; C063912:carbapenemase