Genetic determinants of efficiency of magnetic laser therapy of essential hypertension.
The efficiency of magnetic laser therapy was evaluated in patients with essential hypertension (stages I and II). The role of angiotensinogen, angiotensin-converting enzyme, type II bradykinin receptor, and endothelial nitrogen oxide synthetase gene polymorphism in the realization of hypotensive effect of magnetic laser therapy was evaluated. The hypotensive effect of magnetic laser therapy depends on the polymorphism of the studied genes and is maximum in patients with MM polymorphism of angiotensinogen gene and DD polymorphism of angiotensin-converting enzyme gene. Additive interaction between angiotensin-converting enzyme and angiotensinogen genes in the formation of hemodynamic effects of magnetic laser therapy was detected.
Ponomarenko
G N
GN
S. M. Kirov Military Medical Academy, St. Petersburg, Russia. ponomarenko_g@mail.ru
Obrezan
A G
AG
Stupnitskii
A A
AA
Tishakov
A Yu
AY
Kostin
N A
NA
D000808:Angiotensinogen / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy*; D028022:Low-Level Light Therapy / Q000379:methods*; D008280:Magnetics / Q000627:therapeutic use*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D043782:Receptor, Bradykinin B2 / Q000235:genetics*
D043782:Receptor, Bradykinin B2; D000808:Angiotensinogen; D007703:Peptidyl-Dipeptidase A