title: Generation of reactive oxygen species by a persulfide (BnSSH).
abstract: Hydropersulfides (RS(x)SH) have been implicated as important intermediates in the cell-killing action of the anticancer natural products leinamycin and varacin. It has been suggested that persulfides can mediate the conversion of molecular oxygen to reactive oxygen species (O2*-, H2O2, and HO*). Here, experiments with synthetic benzyl hydrodisulfide (BnSSH) provide direct evidence that persulfides readily decompose to produce reactive oxygen species under physiologically relevant conditions.
authors: Department of Chemistry, University of Missouri-Columbia, Columbia, MO 65211, USA.
authors: Tonika
authors: T
authors: Chatterji
authors: Kripa
authors: K
authors: Keerthi
authors: Kent S
authors: KS
authors: Gates
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D016923:Cell Death; D004220:Disulfides / Q000737:chemistry / Q000378:metabolism; D008954:Models, Biological; D017382:Reactive Oxygen Species / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship; D013440:Sulfides / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D004220:Disulfides; D017382:Reactive Oxygen Species; D013440:Sulfides; C051552:persulfides; C034956:benzyl hydrodisulfide