title: [Experience in donor-recipient gender mismatching heart transplantation: analysis of seven female patients receiving male donor hearts].
abstract: OBJECTIVE
  To summarize the experience in donor-recipient gender mismatching heart transplantation.
  
  
  METHODS
  Seven female patients with end-stage cardiopathy aged 13 approximately 44, underwent orthotopic transplantation of hearts from male donors. Fine-tuning immunosuppressive protocols were adopted: Stanford classic therapy was applied on 3 cases and immunosupression induction therapy was applied on 4 cases. The clinical outcomes were observed for an average of 20 months (5 approximately 54 months).
  
  
  RESULTS
  No acute reject reaction was found in all 7 cases within 3 months postoperatively. The earliest 2 patients died of refractory rejection 38 and 34 months postoperatively due to immunosuppressive withdrawal because of financial difficulty. The other 5 cases resumed their normal work and daily life. No allograft dysfunction, severe opportunistic infection episodes, and injury of liver and kidney functions were found in all cases.
  
  
  CONCLUSIONS
  Fine-tuning immunosuppressive protocols improve the short-term and long-term clinical effects of donor-recipient gender mismatching heart transplantation.
authors: Department of Cardiac Surgery, Union Hospital, Fujian Medical University, Fuzhou 350001, China. drhxs@163.com
authors: Xue-shan
authors: XS
authors: Huang
authors: Dao-zhong
authors: DZ
authors: Chen
authors: Liang-wan
authors: LW
authors: Chen
authors: Feng
authors: F
authors: Lin
authors: Qin-yong
authors: QY
authors: Weng
authors: Han-fan
authors: HF
authors: Qiu
authors: Zhong-yao
authors: ZY
authors: Huang
authors: Chong-xian
authors: CX
authors: Liao
mesh_terms: D000293:Adolescent; D000328:Adult; D002681:China / Q000453:epidemiology; D005260:Female; D006084:Graft Rejection; D016027:Heart Transplantation / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D012737:Sex Factors; D014019:Tissue Donors; D016896:Treatment Outcome