Magnetic targeting and cellular uptake of polymer microcapsules simultaneously functionalized with magnetic and luminescent nanocrystals.
By using a flow channel system for modeling the bloodstream in the circulatory system and by locally creating a magnetic field gradient caused by a permanent magnet, we demonstrate specific trapping of polymer capsules simultaneously functionalized with two types of nanoparticles--magnetic and luminescent nanocrystals. In the regions where the capsules were trapped by the magnetic field, drastically increased uptake of capsules by cells has been observed. The uptake of capsules by cells could be conveniently monitored with a fluorescence microscope by the luminescence of CdTe nanocrystals that had been embedded into the shells of the capsules. Our experiments envisage the feasibility of magnetic targeting of polymer capsules loaded by pharmaceutical agents to pathogenic parts of a tissue.
Zebli
Bernd
B
Susha
Andrei S
AS
Sukhorukov
Gleb B
GB
Rogach
Andrey L
AL
Parak
Wolfgang J
WJ
D001943:Breast Neoplasms / Q000628:therapy; D019187:Cadmium Compounds; D002214:Capsules; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D005260:Female; D006801:Humans; D049449:Luminescence; D008280:Magnetics / Q000627:therapeutic use*; D008954:Models, Biological; D049329:Nanostructures; D011108:Polymers; D013691:Tellurium
D019187:Cadmium Compounds; D002214:Capsules; D011108:Polymers; D013691:Tellurium; C028337:cadmium telluride