Safety review of kava (Piper methysticum) by the Natural Standard Research Collaboration.
This systematic review discusses the proposed uses, dosing parameters, adverse effects, toxicology, interactions and mechanism of action of kava. The widespread concern regarding the potential hepatotoxicity of kava is discussed. A recommendation is made to consolidate and analyse available reports and to continue postmarket surveillance in an international repository to prevent duplicates and promote collection of thorough details at the time of each report so that any association with kava is clearly defined.
Ulbricht
Catherine
C
Natural Standard Research Collaboration, 1 Broadway, 14th Floor, Cambridge, MA 02142, USA. Info@naturalstandard.com
Basch
Ethan
E
Boon
Heather
H
Ernst
Edzard
E
Hammerness
Paul
P
Sollars
David
D
Tsourounis
Candy
C
Woods
Jen
J
Bent
Stephen
S
D003625:Data Collection; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006801:Humans; D020901:Kava / Q000009:adverse effects* / Q000737:chemistry*; D028321:Plant Preparations / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000494:pharmacology
D028321:Plant Preparations