[Effect of tianma gouteng recipe on interfering LV and aortic hypertrophy in renovascular hypertension rats].
OBJECTIVE
To investigate the effect of Tianma Gouteng recipe (TGR) on interfering left ventricular (LV) and aortic hypertrophy and tissue angiotensin II (Ang II) in rats with renovascular hypertension.


METHODS
The animal model of renovascular hypertension was used in this experiment. Hypertensive rats were randomly allocated into model group, Enalapril group and TGR group, and the drugs were used for 6 weeks continuously. During this period, the blood pressure of rats was measured every two weeks. After rats were sacrificed, the wet weight, tissue Ang II level of LV and aorta, and the cardiac index were measured.


RESULTS
One week after renovascular stenosis, the systolic blood pressure (SPS) of model group was increased by 37.4 mmHg, and 7 weeks after stenosis, the LV and aortic hypertrophy was obvious increased, meanwhile, tissue Ang II of LV and aorta was raised markedly (P < 0.01). Contrasting with the model group, blood pressure was reduced and the morphological index was improved in Enalapril group respectively (P < 0.05 or P < 0.01); the wet weight of LV and aorta were reduced, the morphological index was improved, the rise of Ang II in tissue was suppressed, in TGR group significantly.


CONCLUSIONS
TGR can attenuate myocardial and aorta hypertrophy induced by renovascular hypertension, and suppress the rise of Ang II in tissue significantly. This suggests that TGR has the effects on interfering LV and aortic hypertrophy by an independent-antihypertensive way.
Wang
Dan-Qiao
DQ
Geriatrics Institute, Xiyuan hospital, China Academy of Traditional Chinese Medicine, Beijing 100091, China. dq_wang96@hotmail.com
Wang
Wei
W
Sun
Xiao-Fang
XF
Zhao
De-Zhong
DZ
Du
Gui-You
GY
D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001011:Aorta / Q000378:metabolism / Q000473:pathology; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004656:Enalapril / Q000494:pharmacology; D031668:Gastrodia / Q000737:chemistry; D006978:Hypertension, Renovascular / Q000150:complications / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D032070:Uncaria / Q000737:chemistry
D000959:Antihypertensive Agents; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C000589486:tianma gouteng; D000804:Angiotensin II; D004656:Enalapril