title: Neurodegenerative disorders: Parkinson's disease and Huntington's disease.
abstract: Parkinson's disease and Huntington's disease are both model diseases. Parkinson's disease is the most common of several akinetic-rigid syndromes and Huntington's disease is only one of an ever growing number of trinucleotide repeat disorders. Molecular genetic studies and subsequent molecular biological studies have provided fascinating new insights into the pathogenesis of both disorders and there is now real hope for disease modifying treatment in the not too distant future for patients with Parkinson's disease or Huntington's disease.
authors: Academic Neurology Unit, Division of Genomic Medicine, University of Sheffield, UK. o.bandmann@sheffield.ac.uk
authors: S M
authors: SM
authors: Hague
authors: S
authors: S
authors: Klaffke
authors: O
authors: O
authors: Bandmann
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000818:Animals; D015870:Gene Expression / Q000235:genetics; D006801:Humans; D006816:Huntington Disease / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D051379:Mice; D017628:Microglia / Q000378:metabolism; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D010300:Parkinson Disease / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D020734:Parkinsonian Disorders / Q000503:physiopathology; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D040901:Proteomics / Q000379:methods; D051843:Synucleins; D018911:Trinucleotide Repeats / Q000235:genetics; D044767:Ubiquitin-Protein Ligases / Q000235:genetics / Q000378:metabolism
chemical_list: D009419:Nerve Tissue Proteins; D051843:Synucleins; C095278:atrophin-1; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein; D046988:Proteasome Endopeptidase Complex