Substrate specificity of the nateglinide/H(+) cotransport system for phenolic acids.
In clinical, patients usually take many kinds of drugs at the same time. Thus, drug-drug interactions involving transporters can often directly affect the therapeutic safety and efficacy of many important drugs. However, there have been few studies on food-drug interactions involving transporters. Dietary polyphenols have been widely assumed to be beneficial for human health. Polyphenols are found ubiquitously, and they are commercially prepared and used as functional foods. We have reported that ferulic acid, which is one of the most well-known polyphenols and is used as a functional food, affected the transport of nateglinide, an antidiabetic drug, by Caco-2 cells. In this study, we investigated the effects of other polyphenols on the nateglinide/H(+) transport system. We report here that caffeic acid and p-coumaric acid have a different inhibitory manner on the uptake of nateglinide. The results of this study are useful to identify the substrate specificity of the nateglinide/H(+) cotransporter.
Saito
Yoshitaka
Y
Department of Clinical Pharmaceutics and Therapeutics, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12-jo, Nishi 6-chome, Kita-ku, Sapporo 060-0812, Japan.
Itagaki
Shirou
S
Otsuka
Yukio
Y
Kobayashi
Yoko
Y
Okumura
Hideo
H
Kobayashi
Masaki
M
Hirano
Takeshi
T
Iseki
Ken
K
D001692:Biological Transport / Q000187:drug effects; D018938:Caco-2 Cells; D002109:Caffeic Acids / Q000494:pharmacology; D003373:Coumaric Acids / Q000494:pharmacology; D003510:Cyclohexanes / Q000378:metabolism*; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D007004:Hypoglycemic Agents / Q000378:metabolism*; D000077715:Nateglinide; D010636:Phenols / Q000494:pharmacology*; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000378:metabolism; D059808:Polyphenols; D011422:Propionates; D011522:Protons; D027981:Symporters / Q000378:metabolism*
D002109:Caffeic Acids; D003373:Coumaric Acids; D003510:Cyclohexanes; D005419:Flavonoids; D007004:Hypoglycemic Agents; D010636:Phenols; D059808:Polyphenols; D011422:Propionates; D011522:Protons; D027981:Symporters; D000077715:Nateglinide; D010649:Phenylalanine; C495469:p-coumaric acid; C040048:caffeic acid