Recoverable fluorous CBS methodology for asymmetric reduction of ketones.
[reaction: see text]. An operationally simple and recoverable fluorous CBS methodology was developed. The in situ-generated fluorous oxazaborolidine efficiently catalyzed the reduction of ketones with high enantioselectivity and reactivity. The subsequent recycling of the fluorous prolinol precatalyst was achieved by fluorous solid-phase extraction.
Dalicsek
Zoltán
Z
Institute of Biomolecular Chemistry, Chemical Research Center of Hungarian Academy of Science, Budapest.
Pollreisz
Ferenc
F
Gömöry
Agnes
A
Soós
Tibor
T
D002384:Catalysis; D005461:Fluorine / Q000737:chemistry*; D007202:Indicators and Reagents; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry*
D007202:Indicators and Reagents; D007659:Ketones; D011759:Pyrrolidines; D005461:Fluorine; C010509:prolinol