title: Procedure for the parallel preparation of 3-imidazo[1,2-a]pyridin-3-yl-propionic acid derivatives involving Meldrum's acid.
abstract: We describe here an efficient and versatile method for the preparation of 3-imidazo[1,2-a]pyridin-3-yl-propionic acids involving, as a key step, a three-component Michael-type reaction. The extended and validated procedure allowed us to prepare various acids with three diversity points. The method was easily adaptable for parallel synthesis and an approximately 2000-membered 3-imidazo[1,2-a]pyridin-3-yl-propionic acid amide library was prepared in a semiautomated manner.
authors: ComGenex Inc., H-1027, Budapest, Bem rkp. 33-34, Hungary.
authors: János
authors: J
authors: Gerencsér
authors: Gábor
authors: G
authors: Panka
authors: Tamás
authors: T
authors: Nagy
authors: Orsolya
authors: O
authors: Egyed
authors: György
authors: G
authors: Dormán
authors: László
authors: L
authors: Urge
authors: Ferenc
authors: F
authors: Darvas
mesh_terms: D020650:Combinatorial Chemistry Techniques; D004146:Dioxanes / Q000737:chemistry*; D015394:Molecular Structure; D011422:Propionates / Q000737:chemistry*
chemical_list: D004146:Dioxanes; D011422:Propionates; C076489:Meldrum's acid; C029658:propionic acid