Stereocontrolled synthesis of beta-difluoromethylated materials.
Investigation of synthetic routes for regio- and stereocontrolled fluorinated materials with a difluoromethyl group, using ethyl bromodifluoroacetate as a starting material, is described. In particular, (E)-difluoromethylated trisubstituted olefins were prepared via the proton migration reaction catalyzed by using fluoride anion. Further, optically active beta-difluoromethyl esters were obtained by the enzymatic resolution.
Nihei
Takashi
T
Graduate School of Bioscience & Biotechnology and Frontier Collaborative Research Center, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan.
Iwai
Noritaka
N
Matsuda
Tomoko
T
Kitazume
Tomoya
T