title: Effect of hydroxyapatite coating crystallinity on dissolution and osseointegration in vivo.
abstract: Hydroxyapatite (HA) coating with different crystallinities were deposited by plasma spraying and vapor-flame treatment process. Their crystallinities are about 55 and 98%, respectively. These coatings were implanted in cortical bone, muscle, and marrow of dogs. The dissolution and osseointegration behavior were evaluated by scanning electron microscope (SEM) observation histological analysis. The results obtained indicated that after implanted in muscle, a bone-like apatite layer was formed on the surface of as-sprayed coating, which was not observed on the surface of the treated coating. The as-sprayed coating has the ability to induce new bone formation on its surface after implanted in marrow. In contrast, the treated coating displays a limited bone bioactivity. The vapor-flame process diminishes the short-term osseointegration properties of the HA coating, but no significant affection was found after three months implantation. Either in muscle or in cortical bone, treated coating exhibits higher stability than the as-sprayed coating, in some conditions.
authors: Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People's Republic of China. xueweichang@163.com
authors: Weichang
authors: W
authors: Xue
authors: Xuanyong
authors: X
authors: Liu
authors: Xuebin
authors: X
authors: Zheng
authors: Chuanxian
authors: C
authors: Ding
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000502:physiology; D018786:Bone Substitutes; D001842:Bone and Bones / Q000502:physiology; D020099:Coated Materials, Biocompatible; D003460:Crystallization; D004285:Dogs; D017886:Durapatite; D008422:Materials Testing / Q000379:methods; D008855:Microscopy, Electron, Scanning; D018482:Muscle, Skeletal / Q000502:physiology; D016348:Osseointegration / Q000502:physiology; D019736:Prostheses and Implants
chemical_list: D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D017886:Durapatite