title: Impact of pyrexia on neurochemistry and cerebral oxygenation after acute brain injury.
abstract: BACKGROUND
  Postischaemic pyrexia exacerbates neuronal damage. Hyperthermia related cerebral changes have still not been well investigated in humans.
  
  
  OBJECTIVE
  To study how pyrexia affects neurochemistry and cerebral oxygenation after acute brain injury.
  
  
  METHODS
  18 acutely brain injured patients were studied at the onset and resolution of febrile episodes (brain temperature > or = 38.7 degrees C). Intracranial pressure (ICP), brain tissue oxygen tension (PbrO2), and brain tissue temperature (Tbr) were recorded continuously; jugular venous blood was sampled intermittently. Microdialysis probes were inserted in the cerebral cortex and in subcutaneous tissue. Glucose, lactate, pyruvate, and glutamate were measured hourly. The lactate to pyruvate ratio was calculated.
  
  
  RESULTS
  Mean (SD) Tbr rose from 38 (0.5) to 39.3 (0.3) degrees C. Arteriojugular oxygen content difference (AJD(O2)) fell from 4.2 (0.7) to 3.8 (0.5) vol% (p < 0.05) and PbrO2 rose from 32 (21) to 37 (22) mm Hg (p < 0.05). ICP increased slightly and no significant neurochemical alterations occurred. Opposite changes were recorded when brain temperature returned towards baseline.
  
  
  CONCLUSIONS
  As long as substrate and oxygen delivery remain adequate, hyperthermia on its own does not seem to induce any further significant neurochemical alterations. Changes in cerebral blood volume may, however, affect intracranial pressure.
authors: Milan University, Neuroscience Intensive Care, Ospedale Policlinico IRCCS, Milan, Italy. stocchet@policlinico.mi.it
authors: N
authors: N
authors: Stocchetti
authors: A
authors: A
authors: Protti
authors: M
authors: M
authors: Lattuada
authors: S
authors: S
authors: Magnoni
authors: L
authors: L
authors: Longhi
authors: L
authors: L
authors: Ghisoni
authors: M
authors: M
authors: Egidi
authors: E R
authors: ER
authors: Zanier
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001930:Brain Injuries / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology*; D002245:Carbon Dioxide / Q000378:metabolism*; D018450:Disease Progression; D004234:Diuretics, Osmotic / Q000627:therapeutic use; D005260:Female; D005334:Fever / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D006849:Hydrocephalus / Q000188:drug therapy; D019586:Intracranial Hypertension / Q000209:etiology; D008297:Male; D008353:Mannitol / Q000627:therapeutic use; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism*; D012720:Severity of Illness Index; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D004234:Diuretics, Osmotic; D002245:Carbon Dioxide; D008353:Mannitol; D010100:Oxygen