title: Risk factors for mucosal prostatic urethral involvement in superficial transitional cell carcinoma of the bladder.
abstract: OBJECTIVE
  Prostatic transitional cell carcinoma (TCC) may involve urethral mucosa, ducts, acini and stroma of the gland. In this study, we evaluated the risk factors for mucosal prostatic urethral (PU) involvement in superficial TCC of the bladder.
  
  
  METHODS
  The data of 340 consecutive male patients with the diagnosis of primary superficial TCC of the bladder who were treated at our institution were reviewed. Median age of the patients was 64 years and median follow-up was 66 months. The impact of pathological stage, grade, tumour multiplicity and presence of carcinoma in situ (CIS) on mucosal PU involvement were evaluated.
  
  
  RESULTS
  Twenty one patients (6.2%) had mucosal involvement of the PU and concomitant multifocal TCC of the bladder. Of those, 12 patients (3.5%) had macroscopic mucosal involvement of the PU while the other 9 patients (2.7%) had microscopic tumour. Increased pathological stage, grade and tumour multiplicity were found to be risk factors for mucosal PU involvement in patients with superficial bladder cancer. Multivariate analysis showed that only the tumour multiplicity was found to be an independent risk factor for mucosal PU involvement by TCC (p=0.001).
  
  
  CONCLUSIONS
  The incidence of mucosal PU involvement increases as the stage, grade and number of tumours increase in patients with superficial TCC of the bladder. We recommend PU sampling particularly in patients with multiple bladder tumours which may have an impact on further management of these patients.
authors: Dokuz Eylul University School of Medicine Department of Urology, Izmir 35340 Turkey.
authors: M Ugur
authors: MU
authors: Mungan
authors: A Erdem
authors: AE
authors: Canda
authors: Emre
authors: E
authors: Tuzel
authors: Kutsal
authors: K
authors: Yorukoglu
authors: Ziya
authors: Z
authors: Kirkali
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D011471:Prostatic Neoplasms / Q000473:pathology*; D012189:Retrospective Studies; D012307:Risk Factors; D014523:Urethral Neoplasms / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000473:pathology*; D019459:Urothelium / Q000473:pathology*