title: Development of a chipscale integrated microelectrode/microelectronic device for brain implantable neuroengineering applications.
abstract: An ultralow power analog CMOS chip and a silicon based microelectrode array have been fully integrated to a microminiaturized "neuroport" for brain implantable neuroengineering applications. The CMOS integrated circuit (IC) includes preamplifier and multiplexing circuitry, and a hybrid flip-chip bonding technique was developed to fabricate a functional, encapsulated microminiaturized neuroprobe device. Our neuroport has been evaluated using various methods, including pseudospike detection and local excitation measurement, and showed suitable characteristics for recording neural activities. As a proof-of-concept demonstration, we have measured local field potentials from thalamocortical brain slices of rats, suggesting that the new neuroport can form a prime platform for the development of a microminiaturized neural interface to the brain in a single implantable unit. An alternative power delivery scheme using photovoltaic power converter, and an encapsulation strategy for chronic implantation are also discussed.
authors: Division of Engineering, Brown University, Providence, RI 02912, USA. yoon-kyu_song@brown.edu
authors: Yoon-Kyu
authors: YK
authors: Song
authors: William R
authors: WR
authors: Patterson
authors: Christopher W
authors: CW
authors: Bull
authors: Joseph
authors: J
authors: Beals
authors: Naejye
authors: N
authors: Hwang
authors: Andrew P
authors: AP
authors: Deangelis
authors: Christopher
authors: C
authors: Lay
authors: J Lucas
authors: JL
authors: McKay
authors: Arto V
authors: AV
authors: Nurmikko
authors: Matthew R
authors: MR
authors: Fellows
authors: John D
authors: JD
authors: Simeral
authors: John P
authors: JP
authors: Donoghue
authors: Barry W
authors: BW
authors: Connors
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000669:Amplifiers, Electronic; D000818:Animals; D001698:Biomedical Engineering / Q000295:instrumentation / Q000379:methods; D001921:Brain / Q000502:physiology*; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000295:instrumentation* / Q000379:methods; D004582:Electronics, Medical / Q000295:instrumentation / Q000379:methods; D019544:Equipment Failure Analysis; D008839:Microelectrodes; D008904:Miniaturization / Q000379:methods; D009474:Neurons / Q000502:physiology*; D019736:Prostheses and Implants; D011474:Prosthesis Design; D051381:Rats; D018511:Systems Integration; D014584:User-Computer Interface