[Effect of surface modification on surface energy of lactose and performance of dry powder inhalations].
OBJECTIVE
To investigate the effects of surface modification of lactose carrier on performance of dry powder inhalations (DPIs).


METHODS
Modified lactose surface was prepared using a "particle smoothing" process to obtain smooth carrier surface and low surface energy with the presence of magnesium stearate, colloidal silica dioxide and talc. Inverse gas chromatography (IGC) was used to assess the surface energy of treated lactose, and the in vitro deposition of carrier-based IFNa-2b DPIs was evaluated with twin stage impinger.


RESULTS
The flowing property of lactose was greatly improved and the surface energy decreased by the "particle smoothing" process. Decreasing surface energy resulted in greater aspiration fraction of IFNa-2b.


CONCLUSIONS
IGC is a potentially useful tool for rapid formulation design and screening.
Jiang
Rong-gao
RG
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhang
Peng-wei
PW
Wang
Li-qing
LQ
Liu
Heng
H
Pan
Wei-san
WS
Wang
Chun-long
CL
D000280:Administration, Inhalation; D002849:Chromatography, Gas / Q000379:methods; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage* / Q000737:chemistry; D007785:Lactose / Q000008:administration & dosage* / Q000737:chemistry; D010316:Particle Size; D011208:Powders; D011994:Recombinant Proteins; D013229:Stearic Acids / Q000737:chemistry; D013499:Surface Properties; D013627:Talc / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*
D004337:Drug Carriers; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011208:Powders; D011994:Recombinant Proteins; D013229:Stearic Acids; D013627:Talc; C031183:stearic acid; D007785:Lactose