Lack of association with the CD28/CTLA4/ICOS gene region among Norwegian multiple sclerosis patients.
Chromosome region 2q33 encodes several regulators of the immune system, among these the CD28, CTLA4, and ICOS molecules. Involvement of these genes in multiple sclerosis (MS) is not yet clear. We investigated six microsatellites and three SNPs in a relatively large and clinically well characterised Norwegian MS cohort. No associations were observed for any of the markers analysed in 575 MS patients and 551 controls. Associations were neither found when stratifying the material for the HLA-DRB1*1501, DQB1*0602 haplotype, gender, age at onset, disease course nor familial aggregation. In conclusion, this study could not confirm association with the CD28/CTLA4/ICOS gene region.
Lorentzen
Aslaug R
AR
Institute of Immunology, University of Oslo and Rikshospitalet University Hospital, 00207 Oslo, Norway. a.r.lorentzen@studmed.uio.no
Celius
Elisabeth G
EG
Ekstrøm
Per O
PO
Wiencke
Kristine
K
Lie
Benedicte A
BA
Myhr
Kjell-Morten
KM
Ling
Vincent
V
Thorsby
Erik
E
Vartdal
Frode
F
Spurkland
Anne
A
Harbo
Hanne F
HF
D000293:Adolescent; D000328:Adult; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000235:genetics*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics*; D018106:CD28 Antigens / Q000235:genetics*; D060908:CTLA-4 Antigen; D016022:Case-Control Studies; D002648:Child; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D006801:Humans; D060889:Inducible T-Cell Co-Stimulator Protein; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics; D018895:Microsatellite Repeats; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology*; D009664:Norway; D020641:Polymorphism, Single Nucleotide
D015703:Antigens, CD; D000943:Antigens, Differentiation; D000945:Antigens, Differentiation, T-Lymphocyte; D018106:CD28 Antigens; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C489631:HLA-DRB1*15:01 antigen; C556692:ICOS protein, human; D060889:Inducible T-Cell Co-Stimulator Protein; D008562:Membrane Glycoproteins