[Protein C congenital deficiency. A case report].
Protein C is a plasmatic protein that is synthesized by the liver with the help of vitamin K. It regulates thrombin formation and consequently prevents thrombosis. We present a case of a newborn male with change in the color of the right foot index finger who after 4 h showed cyanosis that reached malleolus level. Upon admission we observed generalized pallor, tachycardia and a necrotic lesion in the rightfoot. We suspected a septic process and thus administered cefotaxime, vancomycin and heparin. Platelet levels were 70,000 mm3, thromboplastin 16/12 sec., partial thromboplastin 5829 sec. PCfunctionality 20% and protein S 100%. Even though the patient evolvedfavourably and showed partial recovery, an intratuberous amputation was needed. One year later a prosthesis was fitted. We need to carry out studies that support the use of PC monoclonal antibodies in order to offer better baseline treatment to patients with PC congenital deficiency and improve their quality of live.
de Lemus-Varela
María Lourdes
ML
Departamento de Neonatología, Hospital de Pediatria del Centro Médico Nacional de Occidente, IMSS, Guadalajara, Jal., México. lulalemus@hotmail.com
Arriaga-Dávila
José de Jesús
Jde J
PatriciaSalinas-López
Martha
M
D005528:Foot / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009336:Necrosis / Q000209:etiology; D020151:Protein C Deficiency / Q000150:complications