Biocompatible and biodegradable polymer nanofibers displaying superparamagnetic properties.
Superparamagnetic polymer nanofibers intended for drug delivery and therapy are considered here. Magnetite (Fe3O4) nanoparticles in the diameter range of 5-10 nm were synthesized in aqueous solution. Polymer nanofibers containing magnetite nanoparticles were prepared from commercially available poly(hydroxyethyl methacrylate), PHEMA, and poly-L-lactide (PLLA) by the electrospinning technique. Nanofibers with diameters ranging from 50 to 300 nm were obtained. Nanofibers containing up to 35 wt % magnetite nanoparticles displayed superparamagnetism at room temperature. The blocking temperature was about 50 K for an applied field of 500 Oe, and the saturation magnetization was 3.5 emu g(-1) and 1.1 emu g(-1) for Fe3O4/PHEMA and Fe3O4/PLLA nanofibers, respectively, and depended on the amount of Fe3O4 nanoparticles in the nanocomposites. To test such magnetic nano-objects for applications as drug carriers and drug-release systems we incorporated a fluorescent albumin with dog fluorescein isothiocyanate (ADFI).
Tan
Song Ting
ST
Institute of Polymer Materials, Xiangtan University, Xiangtan 411105, P. R. China. tanst2008@163.com
Wendorff
Joachim H
JH
Pietzonka
Clemens
C
Jia
Zhi Hong
ZH
Wang
Gui Qing
GQ
D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D008280:Magnetics; D049329:Nanostructures / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry* / Q000378:metabolism; D011102:Polyhydroxyethyl Methacrylate / Q000737:chemistry* / Q000378:metabolism; D013696:Temperature
D001672:Biocompatible Materials; D009942:Organometallic Compounds; D011091:Polyesters; D011102:Polyhydroxyethyl Methacrylate; C033616:poly(lactide); D052203:Ferrosoferric Oxide