title: Enhanced tissue factor pathway inhibitor response as a defense mechanism against ongoing local microvascular events of Legg-Calve-Perthes disease.
abstract: The precise pathogenetic basis of Legg-Calve-Perthes disease (LCPD) is currently unknown. Hemostatic abnormalities, i.e., hypercoagulability and/or hypofibrinolysis, were proposed in the genesis of the LCPD. Deficiency of tissue factor pathway inhibitor (TFPI), a critical natural anticoagulant molecule, may lead to a prothrombotic state in a wide variety of conditions. The aim of this study is to assess the circulating TFPI pool in the LCPD. Group I consisted of 44 patients with LCPD and group II comprised 38 healthy children. Median (IQR) TPFI concentration was significantly higher in the group I (p < .0001). Enhanced TFPI response could be regarded as a compensatory defense mechanism against ongoing local microvascular events of occlusion and revascularization of LCPD. TFPI molecule may be an important link between the crossroads of the LCPD genesis and pathogenetic microvascular changes in the disease course. Further investigations are needed to shed light on the endothelial anticoagulant kinetics, the unique microvascular compromise, and the self-limiting nature of the disease.
authors: Department of Orthopaedics and Traumatology, Hacettepe University Medical School, Ankara, Turkey.
authors: Mehmet Cemalettin
authors: MC
authors: Aksoy
authors: Duygu Yazgan
authors: DY
authors: Aksoy
authors: Ibrahim C
authors: IC
authors: Haznedaroglu
authors: Nilgün
authors: N
authors: Sayinalp
authors: Serafettin
authors: S
authors: Kirazli
authors: Mumtaz
authors: M
authors: Alpaslan
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007873:Legg-Calve-Perthes Disease / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology*; D008074:Lipoproteins / Q000097:blood / Q000502:physiology*; D008833:Microcirculation / Q000502:physiology
chemical_list: D008074:Lipoproteins; C051928:lipoprotein-associated coagulation inhibitor