title: Successful pregnancy in a gonadectomized woman with 46,XY gonadal dysgenesis and gonadoblastoma.
abstract: OBJECTIVE
  To present a case of successful pregnancy after conservative bilateral gonadectomy without adjuvant chemotherapy and radiotherapy in a 46,XY gonadal dysgenetic woman with gonadoblastoma and malignant germ cell tumor.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Infertility center in university hospital.
  
  
  METHODS
  An 18-year-old female with 46,XY karyotype underwent bilateral gonadectomy, and the pathology revealed gonadoblastoma with malignant mixed germ cell tumor.
  
  
  METHODS
  Chromosomal analysis, bilateral gonadectomy, donor oocyte, and IVF program.
  
  
  METHODS
  Tumor markers and pregnancy result.
  
  
  RESULTS
  The patient was free from tumor recurrence after 13 years' follow-up. A successful twin pregnancy was achieved after oocyte donation and IVF.
  
  
  CONCLUSIONS
  Gonadectomy without adjuvant therapies could be done in 46,XY gonadal dysgenetic women with gonadoblastoma in view of preservation of future fertility.
authors: Department of Obstetrics and Gynecology, College of Medicine and Hospital, National Taiwan University, Taipei, Taiwan.
authors: Mei-Jou
authors: MJ
authors: Chen
authors: Jehn-Hsiahn
authors: JH
authors: Yang
authors: Tusi-Lien
authors: TL
authors: Mao
authors: Hong-Nerng
authors: HN
authors: Ho
authors: Yu-Shih
authors: YS
authors: Yang
mesh_terms: D000328:Adult; D005260:Female; D006061:Gonadal Dysgenesis, 46,XY / Q000235:genetics / Q000601:surgery*; D018238:Gonadoblastoma / Q000235:genetics / Q000601:surgery*; D006801:Humans; D007231:Infant, Newborn; D050498:Live Birth; D008297:Male; D010051:Ovarian Neoplasms / Q000235:genetics / Q000601:surgery*; D010052:Ovariectomy / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011272:Pregnancy, Multiple