title: Further evidence for association of variants in the AKT1 gene with schizophrenia in a sample of European sib-pair families.
abstract: BACKGROUND
  Involvement of AKT signaling pathways in schizophrenia has been recently suggested, on the basis of several lines of evidence. In addition to impairment of protein-levels and phosphorylation levels in the pathway, association of DNA sequence variants in the AKT1 gene with schizophrenia has been detected in a family sample.
  
  
  METHODS
  We investigated the reported association of DNA sequence variants in the AKT1 gene in a sample of 79 sib-pair families with schizophrenia using the five single nucleotide polymorphisms (SNPs) of the original study and two additional SNPs in the neighborhood of the SNP for which association had been reported.
  
  
  RESULTS
  We obtained statistical significance for single markers (p = .002) and multilocus haplotypes (p = .0013) located in the same region as has been reported in the previous study.
  
  
  CONCLUSIONS
  The replication of association of variants in the AKT1 gene in a family sample with similar ethnical background as in the original study adds further evidence for involvement of AKT1 in development of schizophrenic disorders.
authors: Western Australian Institute of Medical Research, University of Western Australia, Perth, Australia.
authors: Sibylle G
authors: SG
authors: Schwab
authors: Barbara
authors: B
authors: Hoefgen
authors: Claudia
authors: C
authors: Hanses
authors: Margitta Borrmann
authors: MB
authors: Hassenbach
authors: Margot
authors: M
authors: Albus
authors: Bernard
authors: B
authors: Lerer
authors: Matyas
authors: M
authors: Trixler
authors: Wolfgang
authors: W
authors: Maier
authors: Dieter B
authors: DB
authors: Wildenauer
mesh_terms: D005060:Europe / Q000453:epidemiology; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics*; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*
chemical_list: C494918:AKT1 protein, human; D051057:Proto-Oncogene Proteins c-akt