[Development and cardiomyopathy: serum response factor, a key protein].
Serum response factor (SRF) is a widely expressed transcription factor involved in the transcription of various genes linked to muscle differentiation and cellular growth. Recent studies show the pivotal role of SRF in orchestrating genetic programs essential for cardiac development and function. Dominant negative isoforms of SRF resulting from caspase cleavage or alternative splicing have been identified in different forms of cardiomyopathies. This review summarizes the role of SRF, its structure, function and its role in human cardiopathies. Finally, we discuss the results of recently developed murine models which address the role of SRF in the adult heart in vivo. The existing biological data suggest that SRF could be a target of neurohumoral activation which is involved in myocardial hypertrophy. Conversely, inhibition of SRF activity in different murine models leads to dilated cardiomyopathy.
Gary-Bobo
G
G
Biologie moléculaire de la différenciation, université Denis-Diderot, Paris.
Huet
A
A
Li
Z
Z
Méricskay
M
M
Parlakian
A
A
Paulin
D
D
D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000503:physiopathology* / Q000662:veterinary; D004195:Disease Models, Animal; D006321:Heart / Q000254:growth & development*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology* / Q000662:veterinary; D017380:Hypertrophy, Right Ventricular / Q000503:physiopathology* / Q000662:veterinary; D051379:Mice; D026362:Serum Response Factor / Q000502:physiology*
D026362:Serum Response Factor