The effect of flavonol glycoside on the expressions of matrix metalloproteinase-1 in ultraviolet-irradiated cultured human skin fibroblasts.
Long-term and repeated exposure of ultraviolet (UV) light, a harmful environmental stress, on the skin often induces chronic skin diseases, such as skin cancer as well as photo-aging (premature skin aging), and the mechanisms of these skin damages are closely associated with up-regulation of matrix metalloproteinases (MMPs) activities. Here, we investigated the effect of quercetin-3-O-beta-d-(6''-feruloyl)-galactopyranoside isolated from the stems of Viola hondoensis (Violaceae) on the expression of MMPs in UV-irradiated human skin fibroblasts in vitro. Quercetin-3-O-beta-d-(6''-feruloyl)-galactopyranoside markedly reduced UV-induced MMP-1 expression at the protein levels in a dose-dependent manner. Our report is the first description for the ability of quercetin-3-O-beta-d-(6''-feruloyl)-galactopyranoside to regulate UV-induced MMP-1 expression.
Moon
Hyung-In
HI
Department of Dermatology, Seoul National University College of Medicine and Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, Seoul 110-744, Republic of Korea. himun@snu.ac.kr
Lee
Joongku
J
Zee
Ok Pyo
OP
Chung
Jin Ho
JH
D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000032:analysis* / Q000235:genetics; D011794:Quercetin / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects / Q000201:enzymology* / Q000528:radiation effects*; D014466:Ultraviolet Rays; D032413:Viola / Q000737:chemistry*
D005419:Flavonoids; D011794:Quercetin; D020781:Matrix Metalloproteinase 1