title: Impending cardiac tamponade as a primary presentation of hypothyroidism: case report and review of literature.
abstract: OBJECTIVE
  To describe a patient who presented with pericardial effusion and impending cardiac tamponade attributable to hypothyroidism.
  
  
  METHODS
  We present clinical, laboratory, and imaging data for the current patient and review the literature relative to clinical presentation, prevalence, pathophysiology, diagnosis, and treatment of pericardial effusion and tamponade.
  
  
  RESULTS
  In comparison with previously reported cases, our current case is rare, in that our patient, a 51-year-old woman, presented with impending cardiac tamponade as an initial manifestation of hypothyroidism. Echocardiography demonstrated a large pericardial effusion and diastolic right atrial collapse. A pericardial window procedure was performed, and 1,500 mL of fluid was removed. Levothyroxine therapy was initiated. One month later, recurrent pericardial effusion necessitated a similar intervention, after which the patient recovered and was managed by outpatient follow-up and monitoring of the thyrotropin level.
  
  
  CONCLUSIONS
  From our review of the literature, we conclude that impending cardiac tamponade is a rare initial manifestation of hypothyroidism. A high index of suspicion must be maintained for timely diagnosis of pericardial tamponade followed by prompt intervention. Recurrent pericardial effusions are common, necessitating close follow-up. Treatment of the hypothyroidism with levothyroxine is imperative.
authors: University of South Dakota, School of Medicine, Internal Medicine Residency Program, Sioux Valley Hospital, Sioux Falls, South Dakota 57105, USA.
authors: Andrew K
authors: AK
authors: Karu
authors: Wissam I
authors: WI
authors: Khalife
authors: Robert
authors: R
authors: Houser
authors: John
authors: J
authors: VanderWoude
mesh_terms: D002305:Cardiac Tamponade / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D008875:Middle Aged; D013960:Thyroid Function Tests; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D013974:Thyroxine