title: FGFR4 Gly388Arg polymorphism and prognosis of breast and colorectal cancer.
abstract: A functional Gly388Arg variation in the FGFR4 gene has been reported to be associated with breast and colorectal cancer prognostic parameters. To further examine the functional role of this genetic polymorphism at the population level, we assessed the presence of the Arg388 allele in 142 breast carcinoma patients, 179 colorectal carcinoma patients and 220 general population controls with respect to an association with cancer prognosis and/or risk. No significant association with cancer risk, survival or any other prognostic parameters was observed in either breast or colorectal cancer. A pooled analysis of the present and published data on nodal status by FGFR4 genotypes revealed no association in either breast cancer [odds ratio (OR), 1.0; 95% confidence interval (CI), 0.7-1.4; 702 subjects] or colorectal cancer (OR, 1.4; 95% CI, 0.6-3.4; 260 cases). Thus, the FGFR4 polymorphism may not be relevant in predicting nodal involvement of breast cancer or colon cancer patients.
authors: Department of Experimental Oncology, Istituto Nazionale Tumori, Via G. Venezian 1, 20133 Milan, Italy.
authors: Monica
authors: M
authors: Spinola
authors: Vera Piera
authors: VP
authors: Leoni
authors: Jun-Ichi
authors: J
authors: Tanuma
authors: Angela
authors: A
authors: Pettinicchio
authors: Milo
authors: M
authors: Frattini
authors: Stefano
authors: S
authors: Signoroni
authors: Roberto
authors: R
authors: Agresti
authors: Riccardo
authors: R
authors: Giovanazzi
authors: Silvana
authors: S
authors: Pilotti
authors: Lucio
authors: L
authors: Bertario
authors: Fernando
authors: F
authors: Ravagnani
authors: Tommaso A
authors: TA
authors: Dragani
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000235:genetics / Q000473:pathology*; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm / Q000737:chemistry / Q000235:genetics; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011379:Prognosis; D051499:Receptor, Fibroblast Growth Factor, Type 4; D017468:Receptors, Fibroblast Growth Factor / Q000235:genetics*
chemical_list: D004273:DNA, Neoplasm; D017468:Receptors, Fibroblast Growth Factor; C496371:FGFR4 protein, human; D051499:Receptor, Fibroblast Growth Factor, Type 4