Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death.
Disrupted passage through mitosis often leads to chromosome missegregation and the production of aneuploid progeny. Aneuploidy has long been recognized as a frequent characteristic of cancer cells and a possible cause of tumorigenesis. Drugs that target mitotic spindle assembly are frequently used to treat various types of human tumors. These lead to chronic mitotic arrest from sustained activation of the mitotic checkpoint. Here, we review the linkage between the mitotic checkpoint, aneuploidy, adaptation from mitotic arrest, and antimitotic drug-induced cell death.
Weaver
Beth A A
BA
Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA.
Cleveland
Don W
DW
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017209:Apoptosis; D018816:Genes, cdc / Q000502:physiology*; D006801:Humans; D008938:Mitosis / Q000502:physiology*; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D008941:Spindle Apparatus / Q000187:drug effects*
D000970:Antineoplastic Agents