title: Synthesis and degradation of nucleic Acid components by formamide and cosmic dust analogues.
abstract: We show the unprecedented one-pot synthesis of a large suite of pyrimidines (including cytosine and uracil) and purines from formamide in the presence of cosmic-dust analogues (CDAs) of olivines. Since the major problem in the origin of informational macromolecules is the instability of their precursors, we also investigate the stabilizing effect of CDAs on the intrinsic instability of oligonucleotides in formamide.
authors: Dipartimento A.B.A.C., Università della Tuscia, Via San Camillo De Lellis, 01100 Viterbo, Italy. saladino@unitus.it
authors: Raffaele
authors: R
authors: Saladino
authors: Claudia
authors: C
authors: Crestini
authors: Veronica
authors: V
authors: Neri
authors: John R
authors: JR
authors: Brucato
authors: Luigi
authors: L
authors: Colangeli
authors: Fabiana
authors: F
authors: Ciciriello
authors: Ernesto
authors: E
authors: Di Mauro
authors: Giovanna
authors: G
authors: Costanzo
mesh_terms: D002384:Catalysis; D019443:Cosmic Dust; D003596:Cytosine / Q000138:chemical synthesis / Q000378:metabolism; D005559:Formamides / Q000737:chemistry / Q000494:pharmacology*; D058085:Iron Compounds / Q000737:chemistry; D017616:Magnesium Compounds / Q000737:chemistry; D017633:Magnesium Silicates / Q000737:chemistry / Q000494:pharmacology; D013058:Mass Spectrometry; D008855:Microscopy, Electron, Scanning; D009696:Nucleic Acids / Q000138:chemical synthesis* / Q000378:metabolism*; D009841:Oligonucleotides / Q000378:metabolism; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry; D017640:Silicates / Q000737:chemistry; D014498:Uracil / Q000138:chemical synthesis / Q000378:metabolism
chemical_list: D019443:Cosmic Dust; D005559:Formamides; D058085:Iron Compounds; D017616:Magnesium Compounds; D017633:Magnesium Silicates; D009696:Nucleic Acids; D009841:Oligonucleotides; D011687:Purines; D017640:Silicates; C031066:formamide; D014498:Uracil; D003596:Cytosine; C034475:olivine