Neuroprotective effect of cytoflavin during compression injury of the spinal cord.
Cytoflavin normalized energy metabolism, decreased the intensity of lipid peroxidation, and reactivated the antioxidant system in the spinal cord of rats with compression injury at the level of Th10-Th11. The neuroprotective effect of the test preparation manifested in normalization of hindlimb motor function and decrease in mortality rate of animals with spinal cord injury. Neuroprotective activity of cytoflavin was higher than that of Cerebrolysin.
Bul'on
V V
VV
Department of Neuropharmacology, Institute of Experimental Medicine, Russia. sns@iem.spb.ru
Kuznetsova
N N
NN
Selina
E N
EN
Kovalenko
A L
AL
Alekseeva
L E
LE
Sapronov
N S
NS
D000818:Animals; D004338:Drug Combinations; D005486:Flavin Mononucleotide / Q000627:therapeutic use*; D007290:Inosine Diphosphate / Q000627:therapeutic use*; D008297:Male; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D009536:Niacinamide / Q000627:therapeutic use*; D051381:Rats; D013117:Spinal Cord Compression / Q000188:drug therapy*; D013119:Spinal Cord Injuries / Q000188:drug therapy*; D013386:Succinates / Q000627:therapeutic use*
D004338:Drug Combinations; D018696:Neuroprotective Agents; D013386:Succinates; C507879:cytoflavin; D009536:Niacinamide; D005486:Flavin Mononucleotide; D007290:Inosine Diphosphate