title: PSA course after definitive high-dose radiotherapy of localized prostate cancer.
abstract: OBJECTIVE
  After radical prostatectomy, PSA levels that reach near zero values in less than 14 days are associated with a favourable prognosis. The aim of this analysis was to investigate whether PSA also declines to near zero values after combined tele-brachytherapy.
  
  
  METHODS
  Forty-one patient, treated with combined tele-brachytherapy for prostate cancer, were followed for at least 2 years after treatment with repeated PSA measurements.
  
  
  RESULTS
  PSA values <1.0 ng/ml were only reached after 15 months; near zero PSA levels were not reached until 18-24 months after treatment (median: 0.25 ng/ml).
  
  
  CONCLUSIONS
  A PSA decline to near zero values occurs after definitive tele-brachytherapy, but it takes longer than after surgery (18-24 months).
authors: Klinik und Poliklinik für Strahlentherapie--Radioonkologie, Universitätsklinikum Münster, Germany. pschuel@uni-muenster.de
authors: Patrick
authors: P
authors: Schüller
authors: Ulrich
authors: U
authors: Schäfer
authors: Oliver
authors: O
authors: Micke
authors: Joan E
authors: JE
authors: Panke
authors: Normann
authors: N
authors: Willich
mesh_terms: D000368:Aged; D001918:Brachytherapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000532:radiotherapy*; D011879:Radiotherapy Dosage
chemical_list: D017430:Prostate-Specific Antigen