title: Novel phosphorus radical-based routes to horsfiline.
abstract: [reaction: see text]. Radicals derived from the phosphorus reagents, ethylpiperidine hypophosphite (EPHP) and diethylphosphine oxide (DEPO), are used in two related approaches to synthesis of the alkaloid horsfiline (1). In particular, DEPO proves beneficial for effecting cyclizations at 80 degrees C that are difficult or impossible with Bu(3)SnH.
authors: WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, UK. john.murphy@strath.ac.uk
authors: John A
authors: JA
authors: Murphy
authors: Régis
authors: R
authors: Tripoli
authors: Tanweer A
authors: TA
authors: Khan
authors: Umesh W
authors: UW
authors: Mali
mesh_terms: D002625:Chemistry, Organic / Q000379:methods; D003500:Cyclization; D015394:Molecular Structure; D010720:Phosphines / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D013696:Temperature
chemical_list: D010720:Phosphines; D013141:Spiro Compounds; C443722:horsfiline