title: Frequency of a tau genotype in amyotrophic lateral sclerosis.
abstract: We investigated the susceptibility of the dinucleotide polymorphism A0 in the tau gene to amyotrophic lateral sclerosis (ALS). In 416 unrelated patients with ALS and 242 control subjects the A0/A0 genotype was not associated with the pooled sample of ALS cases. Subgroup analysis revealed that in sporadic ALS the A0 polymorphism was significantly overrepresented. There was no association of the A0/A0 genotype with the age and site of disease onset or the presence of dementia. The studied tau genotype may contribute to the multifactorial genetic background of ALS.
authors: Department of Neurology, Jewish Hospital, Heinz-Galinski-Strasse 1, 13347 Berlin, Germany. muench@jkb-online.de
authors: Christoph
authors: C
authors: Münch
authors: Florian
authors: F
authors: Prechter
authors: Renshi
authors: R
authors: Xu
authors: Peter
authors: P
authors: Linke
authors: Johannes
authors: J
authors: Prudlo
authors: Magdalena
authors: M
authors: Kuzma
authors: Hubert
authors: H
authors: Kwiecinski
authors: Albert C
authors: AC
authors: Ludolph
authors: Thomas
authors: T
authors: Meyer
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D016875:tau Proteins / Q000235:genetics*
chemical_list: D016875:tau Proteins