title: Are maternal hypertension and small-for-gestational age risk factors for severe intraventricular hemorrhage and cystic periventricular leukomalacia? Results of the EPIPAGE cohort study.
abstract: OBJECTIVE
  The purpose of this study was to examine the relationships between different causes of preterm delivery (eg, maternal hypertension, small-for-gestational age [SGA], other) and cerebral damage (eg, cystic periventricular leukomalacia [c-PVL], grade III intraventricular hemorrhage [IVH], and intra-parenchymal hemorrhage [IPH]).
  
  
  METHODS
  This study included 1902 very preterm singletons who were transferred to neonatal intensive care units in 9 French regions. We used logistic regression models to compare the risk of cerebral injury associated with maternal hypertension, SGA, and all other causes of preterm delivery.
  
  
  RESULTS
  We found that the risk of c-PVL and grade III IVH was higher in infants born after preterm premature rupture of membranes (PPROM) with short latency or idiopathic preterm labor than in infants born to hypertensive mothers. We show that SGA and antepartum maternal hemorrhage significantly increase the risk of IPH.
  
  
  CONCLUSIONS
  Our results show that infants born to hypertensive mothers have a lower risk of cerebral injuries than infants born following idiopathic preterm labor and PPROM because they are less exposed to prenatal infection.
authors: Inserm U149 Research Unit on Perinatal Health and Women's Health, Villejuif, France. ancel@vjf.inserm.fr
authors: Pierre-Yves
authors: PY
authors: Ancel
authors: Stéphane
authors: S
authors: Marret
authors: Béatrice
authors: B
authors: Larroque
authors: Catherine
authors: C
authors: Arnaud
authors: Véronique
authors: V
authors: Zupan-Simunek
authors: Marcel
authors: M
authors: Voyer
authors: Jean-Christophe
authors: JC
authors: Rozé
authors: Jacqueline
authors: J
authors: Matis
authors: Antoine
authors: A
authors: Burguet
authors: Bernard
authors: B
authors: Ledésert
authors: Monique
authors: M
authors: André
authors: Véronique
authors: V
authors: Pierrat
authors: Monique
authors: M
authors: Kaminski
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D002543:Cerebral Hemorrhage / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D002552:Cerebral Ventricles; D015331:Cohort Studies; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000150:complications; D006801:Humans; D006973:Hypertension / Q000150:complications*; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D007969:Leukomalacia, Periventricular / Q000209:etiology / Q000473:pathology / Q000517:prevention & control; D008297:Male; D007752:Obstetric Labor, Premature / Q000150:complications; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors; D014592:Uterine Hemorrhage / Q000150:complications
chemical_list: D000305:Adrenal Cortex Hormones