title: Preparation of shell cross-linked nano-objects from hybrid-peptide block copolymers.
abstract: Supramolecular structures formed by self-assembly of diblock copolymers in solution are stable over restricted environmental conditions: concentration, temperature, pH, or ion strength among others. To enlarge their domain of application, it appears necessary to develop stabilization strategies. We report here different strategies to stabilize the shell of micelles formed by self-assembly of amphiphilic polydiene-b-polypeptide diblock copolymers. For this purpose, covalent bonds can be formed between either amine or carboxylic acid groups distributed along the soluble peptide block and a cross-linking agent that contains respectively aldehyde or amine functions. Shell stabilization affords systems with unique properties that combine three main advantages: shape persistence, control of the porosity, and stimuli-responsive behavior. The covalent capture of such macromolecular objects has been studied by light scattering, AFM, and conductimetry measurements.
authors: Laboratoire de Chimie des Polymères Organiques (LCPO-UMR5629), ENSCPB-University Bordeaux 1, 16, Av. Pey Berland, 33607 Pessac Cedex, France.
authors: Juan
authors: J
authors: Rodríguez-Hernández
authors: Jérôme
authors: J
authors: Babin
authors: Bruno
authors: B
authors: Zappone
authors: Sébastien
authors: S
authors: Lecommandoux
mesh_terms: D003432:Cross-Linking Reagents / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008823:Micelles; D015394:Molecular Structure; D036103:Nanotechnology; D010455:Peptides / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013696:Temperature
chemical_list: D003432:Cross-Linking Reagents; D008823:Micelles; D010455:Peptides; D011108:Polymers