title: [Consequences of replacing abacavir for indinavir in successful antiretroviral treatment of a patient with HIV infection].
abstract: BACKGROUND
  Simplification of combined antiretroviral therapy in HIV-infected patients is possible, but virological success can be compromised by the development or emergence of resistant viruses.
  
  
  METHODS
  Worsening renal functioning in a patient under successful combination antiretroviral therapy resulted led to the replacement of indinavir by abacavir. Eight weeks later, his viral load rose and he developed a mutant virus resistant to all the nucleoside analogs.
  
  
  CONCLUSIONS
  Our case report illustrates the danger of streamlining combined antiretroviral therapy composed only of nucleoside analogs in patients already successfully treated with nucleoside analogs, by exposing them to the risk of the emergence of a mutant virus.
authors: Service de microbiologie, Hôpital Louis Mourier, AP-HP, Columbes. salim.gaba@lmr.aphop-paris.fr
authors: S
authors: S
authors: Gaba
authors: E
authors: E
authors: Mortier
authors: C
authors: C
authors: Branger
authors: P
authors: P
authors: Vinceneux
mesh_terms: D000368:Aged; D019380:Anti-HIV Agents / Q000494:pharmacology*; D015224:Dideoxynucleosides / Q000494:pharmacology*; D024882:Drug Resistance, Viral; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D019469:Indinavir / Q000494:pharmacology*; D008297:Male; D009154:Mutation; D019562:Viral Load; D000099227:Abacavir
chemical_list: D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D019469:Indinavir; D000099227:Abacavir