title: [Alterations in the structure of the epiretinal membranes in PVR -- assumptions and reality].
abstract: BACKGROUND
  Proliferative vitreoretinopathy (PVR) is known to be the main cause of failure for routine retinal detachment surgery. Our aim was to document the ultrastructural changes in the epiretinal membranes in cases of PVR.
  
  
  METHODS
  Epiretinal membranes were taken during vitrectomy of 64 patients with different stages of PVR and further analysed using transmission and scanning electron microscopy.
  
  
  RESULTS
  In the early stages of the disease mainly retinal pigment epithelial (RPE) cells, fibroblasts and occasional glial cells were found. Moreover, some of the RPE cells showed altered characteristics. In contrast, epiretinal membranes from the developed stages of PVR were comprised mostly of fibroblasts and a considerably diminished number of RPE cells. Cells with marks of degeneration were generally found.
  
  
  CONCLUSIONS
  Our results point out that epiretinal membranes in PVR are dynamic structures, constantly changing their cell and matrix composition with the progression of the disease. The morphological changes together with the clinical data are important points to consider when discussing the most appropriate therapeutic approach for each case.
authors: Clinic of Ophthalmology, Military Medical Academy, Sofia. christinavidinova@yahoo.com
authors: C
authors: C
authors: Vidinova
authors: L
authors: L
authors: Voinov
authors: N
authors: N
authors: Vidinov
mesh_terms: D016923:Cell Death / Q000502:physiology; D019773:Epiretinal Membrane / Q000473:pathology*; D005109:Extracellular Matrix / Q000000981:diagnostic imaging; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D010857:Pigment Epithelium of Eye / Q000000981:diagnostic imaging; D011183:Postoperative Complications / Q000473:pathology; D011509:Proteoglycans / Q000648:ultrastructure; D012162:Retinal Degeneration / Q000473:pathology; D012163:Retinal Detachment / Q000601:surgery; D017211:Treatment Failure; D014463:Ultrasonography; D014821:Vitrectomy; D018630:Vitreoretinopathy, Proliferative / Q000473:pathology*
chemical_list: D011509:Proteoglycans