Gonadotropin receptors: role of post-translational modifications and post-transcriptional regulation.
This review focuses on the post-translational modifications of LH and FSH receptors and recent studies on the regulation of LH receptor expression mediated by an RNA binding protein. Both LH and FSH receptors undergo extensive post-translational modifications. N-linked glycosylation occurs co-translationally and plays a role in the maturation and processing of the receptor, while palmitoylation is involved in receptor endocytosis and post-endocytic trafficking. A third type of post-translational modification is phosphorylation and its function has been reviewed. Finally, the regulation of LH receptor at the mRNA level by an RNA binding protein is discussed in the context of ovarian function.
Menon
K M J
KM
Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, 48109-0617, USA. kmjmenon@umich.edu
Clouser
Christine L
CL
Nair
Anil K
AK
D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology; D006031:Glycosylation; D006801:Humans; D010168:Palmitates / Q000378:metabolism; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D021381:Protein Transport; D012333:RNA, Messenger / Q000378:metabolism*; D011962:Receptors, FSH / Q000096:biosynthesis / Q000378:metabolism*; D011974:Receptors, LH / Q000096:biosynthesis / Q000378:metabolism*; D014158:Transcription, Genetic / Q000502:physiology
D010168:Palmitates; D012333:RNA, Messenger; D011962:Receptors, FSH; D011974:Receptors, LH