Id1 gene expression and regulation in human thyroid tissue.
The Id genes encode helix-loop-helix (HLH) transcription proteins that lack a DNA binding basic domain. Id proteins (Id1, Id2, Id3, and Id4) function as dominant negative regulators of basic HLH transcription factors by forming inactive heterodimers. Recent studies suggest that the Id proteins participate in the regulation of cell growth, differentiation, tumorigenesis and angiogenesis in a variety of cell types. This report summarizes studies done in our laboratory on the expression and regulation of the Id1 gene in human thyroid tissue, the result of activation of the major mitogen signal transduction pathways on Id1 gene expression, and the effect of the Id1 gene on thyroid cancer cell growth and differentiation.
Kebebew
Electron
E
University of California, San Francisco, Department of Surgery and UCSF Comprehensive Cancer Center, San Francisco, California 94143, USA. kebebewe@surgery.ucsf.edu
D001483:Base Sequence; D002454:Cell Differentiation; D005786:Gene Expression Regulation; D018257:Helix-Loop-Helix Motifs; D006801:Humans; D007150:Immunohistochemistry; D051798:Inhibitor of Differentiation Protein 1 / Q000235:genetics* / Q000378:metabolism*; D008934:Mitogens / Q000378:metabolism; D008969:Molecular Sequence Data; D009928:Organ Specificity; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D013961:Thyroid Gland / Q000378:metabolism* / Q000473:pathology; D013964:Thyroid Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism
C497453:ID1 protein, human; D051798:Inhibitor of Differentiation Protein 1; D008934:Mitogens; D012333:RNA, Messenger; D014157:Transcription Factors