title: Hemophagocytic lymphohistiocytosis associated with visceral leishmaniasis: a case report.
abstract: Leishmania-associated hemophagocytic lymphohistiocytosis is a rare clinicopathological entity. This condition is often difficult to diagnose, so treatment is often delayed. This report describes the case of a 5-year-old boy who was admitted with fever of 1 month's duration, hepatosplenomegaly, and pancytopenia. Serum testing showed elevated transaminase levels, hypertriglyceridemia, hyperferritinemia, and normal fibrinogen level. Hemophagocytic lymphohistiocytosis was diagnosed on bone marrow examination. The patient was tested for various infectious agents. He was negative for all except Leishmania, which was detected by indirect fluorescent antibody testing. Treatment with amphotericin B resulted in a dramatic resolution of all signs and symptoms within 1 week.
authors: Department of Pediatrics, Başkent University, Faculty of Medicine, Adana Teaching and Medical Research Center, Adana, Turkey. heozyurek@yahoo.com
authors: Emel
authors: E
authors: Ozyürek
authors: Figen
authors: F
authors: Ozçay
authors: Basak
authors: B
authors: Yilmaz
authors: Namik
authors: N
authors: Ozbek
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D002675:Child, Preschool; D015616:Histiocytosis, Non-Langerhans-Cell / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007898:Leishmaniasis, Visceral / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D016896:Treatment Outcome
chemical_list: D000666:Amphotericin B