title: [Expression of Survivin and Bcl-2 in laryngeal squamous cell carcinoma and their significance].
abstract: OBJECTIVE
  To research the expression of Survivin and Bcl-2 protein in laryngeal squamous cell carcinoma (LSCC) and the correlation between them.
  
  
  METHODS
  Immunohistochemical (SP) method was used to detect the expression of Survivin and Bcl-2 in 64 cases of LSCC, 28 cases of normal laryngeal mucous membrane and 20 cases of laryngeal benign lesion. The relationship among them was studied by statistical analysis.
  
  
  RESULTS
  Survivin protein was expressed in 43 of 64 (67.2%) samples of LSCC, just 2 samples was expressed in laryngeal benign lesion (10%) and 1 sample expressed in normal laryngeal mucosa (3.6%). The over expression of Survivin was related to the tumor's location, clinical stage, histological grade, lymphatic metastasis. The expression of Survivin was correlated with the expression of Bcl-2.
  
  
  CONCLUSIONS
  Survivin may play an important role in the pathway of carcinogenesis, progress and metastasis of LSCC,it is feasible for early diagnosis and precaution. Bcl-2 and Survivin may play synergetic roles in the pathogenesis of LSCC.
authors: Department of Otorhinolaryngology, the First Affiliated Hospital of China Medical University, Shenyang, 110001, China. wangjizhe2004@sina.com
authors: Jizhe
authors: J
authors: Wang
authors: Chao
authors: C
authors: Guan
authors: Shouchen
authors: S
authors: Wang
authors: Bin
authors: B
authors: Chen
authors: Jialiang
authors: J
authors: Sun
authors: Wenyue
authors: W
authors: Ji
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008869:Microtubule-Associated Proteins / Q000096:biosynthesis*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D000077022:Survivin
chemical_list: C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D000077022:Survivin