Extradigestive manifestation of Helicobacter pylori infection in children and adolescents.
Helicobacter pylori infection fulfills each of Koch's postulates as a human pathogen causing chronic active gastritis. Disease consequences that develop in a subset of infected subjects include peptic ulcerations, gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. More recently, multiple publications have advocated a role for H. pylori infection in causing a variety of extraintestinal manifestations. Many of these reports suffer from being case reports or case series without adequate controls. As a result, purported manifestations may simply be coincidental in nature. On the other hand, increasing evidence supports H. pylori infection as a cause of sideropenic (refractory iron deficiency) anemia. Moderate evidence supports H. pylori gastric infection as a cause of some cases of immune thrombocytopenic purpura due to molecular mimicry. Guidelines should be adjusted in accordance with advancing knowledge in the field.
Sherman
Philip M
PM
Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada. sherman@sickids.ca
Lin
Frank Y H
FY
D000293:Adolescent; D018798:Anemia, Iron-Deficiency / Q000382:microbiology; D002648:Child; D006130:Growth Disorders / Q000382:microbiology; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori / Q000502:physiology; D006801:Humans; D013272:Stomach Diseases / Q000382:microbiology