Epileptiform EEG abnormalities in children with language regression.
The authors examined the records of 149 children with language regression (LR) who had overnight EEG monitoring. Children with isolated LR had a higher frequency of epileptiform abnormalities (60%) than those with LR in the context of autistic regression (31%, p = 0.002) and also a higher rate of clinical seizures (33% vs 8%, p < 0.001). EEG abnormalities in the LR only group were also more prominent. This suggests two subtypes of language regression.
McVicar
K A
KA
Department of Neurology, The Comprehensive Epilepsy Management Center, Montefiore Medical Center, The Albert Einstein College of Medicine, Bronx, NY, USA. kmcvicar1@optonline.net
Ballaban-Gil
K
K
Rapin
I
I
Moshé
S L
SL
Shinnar
S
S
D000200:Action Potentials / Q000502:physiology; D017668:Age of Onset; D001321:Autistic Disorder / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology; D002675:Child, Preschool; D018450:Disease Progression; D004569:Electroencephalography; D004827:Epilepsy / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007805:Language Development Disorders / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D008297:Male; D008991:Monitoring, Physiologic; D017286:Polysomnography; D011237:Predictive Value of Tests; D011379:Prognosis; D012043:Regression, Psychology; D012189:Retrospective Studies; D012737:Sex Factors