A case of peripheral T-cell lymphoma unspecified involving subcutaneous tissue.
A 36-year-old man presented with a 3-year-old red-brown plaque with subcutaneous nodules on his left thigh. Although a similar lesion was observed on his right thigh 3 years earlier, it spontaneously disappeared 1 year later. However, the lesion on the left thigh was growing larger. Histologically, the lesion showed a diffuse and dense infiltration of atypical lymphocytes extending from the superficial dermis to the subcutaneous tissue. Severe lobular panniculitis, composed of small- and medium-sized atypical lymphocytes and large normal histiocytes, was observed in the subcutaneous adipose tissue. Immunohistochemical studies revealed a post-thymic T-cell phenotype. A genetic analysis demonstrated a rearrangement of the T-cell receptor chain gene. The left skin lesion also gradually disappeared after skin biopsy without therapy, and he continues to be in remission.
Futagami
Ayako
A
Department of Dermatology, Nippon Medical School, Main Hospital, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan. aya-f@nms.ac.jp
Aoki
Mikako
M
Kawana
Seiji
S
D000328:Adult; D015139:Blotting, Southern; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D016411:Lymphoma, T-Cell, Peripheral / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D009365:Neoplasm Regression, Spontaneous; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology; D040521:Subcutaneous Tissue / Q000473:pathology