[Alkylating damage by dipin of hematopoietic and stromal cells of the bone marrow].
Effect of alkylating agent dipin was studied on hematopoietic (CFU-S) and stromal (CFU-F) progenitor cells. Single administration of dipin (0.06 mg/g) to adult (CBAxC57Bl/6) F1 hybrid mice induced a long-term (2 years) oscillations in the numbers of day 7 CFU-S and day 11 CFU-S in the bone marrow and spleen. Dipin also damaged the hematopoietic stroma as indicated by decreased numbers of CFU-F which remained low for at least a year. The capacity of stromal cells to form ectopic hematopoietic foci was considerably inhibited and also remained low for 10 months. The obtained data suggest high dipin sensitivity of the earliest hematopoietic and stromal cells. The dynamics of CFU-S numbers in the hematopoietic organs supports their functioning on the basis of clonal succession (Kay, 1965).
Domaratskaia
E I
EI
Bueverova
E I
EI
Paiushina
O D
OD
Starostin
V I
VI
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000633:toxicity*; D001388:Aziridines / Q000633:toxicity*; D001854:Bone Marrow Cells / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D051379:Mice; D013154:Spleen / Q000166:cytology; D017154:Stromal Cells / Q000187:drug effects
D018906:Antineoplastic Agents, Alkylating; D001388:Aziridines; C007526:dipin