Hypoxia-responsive transcription factors.
Hypoxia is a common pathophysiological occurrence with a profound impact on the cellular transcriptome. The consequences of hypoxia-induced or hypoxia-repressed gene expression have important implications in disease processes as diverse as tumour development and chronic inflammation. While the hypoxia-inducible factor (HIF-1) plays a major role in controlling the ubiquitous transcriptional response to hypoxia, it is clear that a number of other transcription factors are also activated either directly or indirectly. In this review, we comprehensively discuss the transcription factors that have been reported to be hypoxia-responsive and the signalling mechanisms leading to their activation. Understanding such events will enhance our understanding of cellular oxygen sensing.
Cummins
Eoin P
EP
Department of Medicine and Therapeutics, The Conway Institute for Biomolecular and Biomedical Research and the Dublin Molecular Medicine Centre, University College Dublin, Belfield, Dublin, 4, Ireland.
Taylor
Cormac T
CT
D000818:Animals; D022782:CCAAT-Enhancer-Binding Protein-beta / Q000502:physiology; D015687:Cell Hypoxia / Q000502:physiology; D017362:Cyclic AMP Response Element-Binding Protein / Q000502:physiology; D051766:Early Growth Response Protein 1 / Q000502:physiology; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D051793:Hypoxia-Inducible Factor 1 / Q000502:physiology; D016328:NF-kappa B / Q000502:physiology; D016329:Sp1 Transcription Factor / Q000502:physiology; D051705:Sp3 Transcription Factor / Q000502:physiology; D018808:Transcription Factor AP-1 / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology*; D016159:Tumor Suppressor Protein p53 / Q000502:physiology
D022782:CCAAT-Enhancer-Binding Protein-beta; D017362:Cyclic AMP Response Element-Binding Protein; D051766:Early Growth Response Protein 1; D051793:Hypoxia-Inducible Factor 1; D016328:NF-kappa B; D016329:Sp1 Transcription Factor; D018808:Transcription Factor AP-1; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53; D051705:Sp3 Transcription Factor