Delineation of the function of a major gamma delta T cell subset during infection.
Gammadelta T cells play important but poorly defined roles in pathogen-induced immune responses and in preventing chronic inflammation and pathology. A major obstacle to defining their function is establishing the degree of functional redundancy and heterogeneity among gammadelta T cells. Using mice deficient in Vgamma1+ T cells which are a major component of the gammadelta T cell response to microbial infection, a specific immunoregulatory role for Vgamma1+ T cells in macrophage and gammadelta T cell homeostasis during infection has been established. By contrast, Vgamma1+ T cells play no significant role in pathogen containment or eradication and cannot protect mice from immune-mediated pathology. Pathogen-elicited Vgamma1+ T cells also display different functional characteristics at different stages of the host response to infection that involves unique and different populations of Vgamma1+ T cells. These findings, therefore, identify distinct and nonoverlapping roles for gammadelta T cell subsets in infection and establish the complexity and adaptability of a single population of gammadelta T cells in the host response to infection that is not predetermined, but is, instead, shaped by environmental factors.
Andrew
Elizabeth M
EM
School of Biochemistry and Microbiology, University of Leeds, Leeds, United Kingdom.
Newton
Darren J
DJ
Dalton
Jane E
JE
Egan
Charlotte E
CE
Goodwin
Stewart J
SJ
Tramonti
Daniela
D
Scott
Philip
P
Carding
Simon R
SR
D000818:Animals; D002465:Cell Movement / Q000235:genetics / Q000276:immunology; D002478:Cells, Cultured; D018920:Coculture Techniques; D003602:Cytotoxicity, Immunologic / Q000235:genetics; D005260:Female; D016130:Immunophenotyping; D008089:Listeria monocytogenes / Q000254:growth & development / Q000276:immunology / Q000472:pathogenicity; D008088:Listeriosis / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D008103:Liver Cirrhosis / Q000235:genetics / Q000276:immunology / Q000382:microbiology; D008262:Macrophage Activation / Q000235:genetics / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000096:biosynthesis / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology*; D013997:Time Factors
D016692:Receptors, Antigen, T-Cell, gamma-delta