title: Anti-androgenic activities of Ganoderma lucidum.
abstract: The inhibitory effects of methanol extracts of 19 edible and medicinal mushrooms on 5alpha-reductase activity were examined. The extract of Ganoderma lucidum Fr. Krast (Ganodermataceae) showed the strongest 5alpha-reductase inhibitory activity. The treatment of the fruit body of Ganoderma lucidum or the extract prepared from it significantly inhibited the testosterone-induced growth of the ventral prostate in castrated rats. These results showed that Ganoderma lucidum might be a useful ingredient for the treatment of benign prostatic hyperplasia (BPH).
authors: Department of Forest and Forest Products Science, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan.
authors: Rumi
authors: R
authors: Fujita
authors: Jie
authors: J
authors: Liu
authors: Kuniyoshi
authors: K
authors: Shimizu
authors: Fumiko
authors: F
authors: Konishi
authors: Kiyoshi
authors: K
authors: Noda
authors: Shoichiro
authors: S
authors: Kumamoto
authors: Chie
authors: C
authors: Ueda
authors: Hisatoshi
authors: H
authors: Tajiri
authors: Shuhei
authors: S
authors: Kaneko
authors: Yoshitaro
authors: Y
authors: Suimi
authors: Ryuichiro
authors: R
authors: Kondo
mesh_terms: D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D042944:Cholestenone 5 alpha-Reductase / Q000037:antagonists & inhibitors; D005260:Female; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D011467:Prostate / Q000187:drug effects / Q000254:growth & development; D011470:Prostatic Hyperplasia / Q000188:drug therapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D020940:Reishi
chemical_list: D000726:Androgen Antagonists; D010936:Plant Extracts; D042944:Cholestenone 5 alpha-Reductase