Effect of sodium diclofenac on microcirculation and composition of the lymph during fever reaction.
Therapeutic effect of sodium diclofenac during fever reaction is associated not only with specific modulation of thermoregulation, but also with the increase in the count of lymphocytes transported with the lymph into systemic circulation, stimulation of lymph microcirculation, and improvement of metabolism in the interstitial space. This preparation inhibited kininogenesis and stimulated degradation of kinins. Sodium diclofenac serves as a universal inhibitor of the kallikrein-kinin system.
Tagirova
D R
DR
Department of Pathophysiology, Kazan State Medical University.
Mukhutdinova
F I
FI
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004008:Diclofenac / Q000494:pharmacology*; D005260:Female; D005334:Fever / Q000139:chemically induced / Q000378:metabolism*; D007610:Kallikreins / Q000378:metabolism; D007705:Kinins / Q000378:metabolism; D008196:Lymph / Q000737:chemistry*; D008297:Male; D008833:Microcirculation / Q000187:drug effects*; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007705:Kinins; D004008:Diclofenac; D007610:Kallikreins