Neurofibromatosis type 1: spinal manifestations of a systemic disease.
Neurofibromatosis type 1 (NF1) is an autosomal dominant congenital dysplasia of the neural crest cells that affects the development of tissue and structures arising from the 3 germinal layers. Affected patients may present with spinal deformities or with bone or soft tissue abnormalities. Imaging plays an important role in the evaluation of these patients. In this article, a working diagnosis approach is proposed and the spectrum of spinal imaging findings in the NF1 patient is reviewed.
Restrepo
Carlos S
CS
Department of Radiology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Riascos
Roy F
RF
Hatta
Ami A
AA
Rojas
Rafael
R
D003937:Diagnosis, Differential; D006801:Humans; D008279:Magnetic Resonance Imaging; D009456:Neurofibromatosis 1 / Q000150:complications* / Q000000981:diagnostic imaging*; D013122:Spinal Diseases / Q000000981:diagnostic imaging* / Q000209:etiology*; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography