title: Anterior resection of rectal cancer without bowel preparation and diverting stoma.
abstract: OBJECTIVE
  Since the introduction of total mesorectal excision (TME) as the standard operation technique for rectal cancer, anastomotic leakage percentages of up to 18% have been reported. To prevent such leakage, the use of mechanical bowel preparation and also the construction of a diverting ileostoma or colostomy have been standard procedures for years. In our institute, however, all patients undergoing colorectal surgery are operated upon without these measures. The present study was undertaken to investigate the results of this strategy in terms of the occurrence of postoperative anastomotic leakage.
  
  
  METHODS
  All patients who underwent an elective (low) anterior resection between January 1996 and December 2001 (n = 144) entered the study. The clinical and pathological records of these patients were reviewed retrospectively. The exclusion criteria were patients with fixed rectal carcinoma who received preoperative radiotherapy and/or a stoma only at operation, emergency operations, abdominoperoneal resections, and Hartmann's procedures.
  
  
  RESULTS
  Anastomotic leakage occurred in 7 out of 144 patients (4.9%). There was a trend toward a higher leakage frequency in men, in patients with a distal anastomosis, in patients with a stapled anastomosis, and in patients with a T3-T4 tumor or with positive lymph nodes. None of these factors, however, had a significant prognostic value based on a univariate or multivariate analysis. Those who died after leakage tended to be older than those who did not (P < 0.05).
  
  
  CONCLUSIONS
  A (low) anterior resection can be performed safely without mechanical bowel preparation or a diverting stoma, and results in an anastomotic leakage percentage of less than 5%. Appropriate selection of patients may be important, but none of the investigated patient- or tumor-related factors could be identified as decisive.
authors: Department of Surgery, Medisch Spectrum Twente, Enschede, The Netherlands.
authors: Eline A
authors: EA
authors: Vlot
authors: Clark J
authors: CJ
authors: Zeebregts
authors: Jos J G M
authors: JJ
authors: Gerritsen
authors: H Jan
authors: HJ
authors: Mulder
authors: Walter J B
authors: WJ
authors: Mastboom
authors: Joost M
authors: JM
authors: Klaase
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002400:Cathartics / Q000627:therapeutic use; D003082:Colectomy / Q000009:adverse effects / Q000379:methods*; D003125:Colostomy; D004733:Enema; D005243:Feces; D005260:Female; D006801:Humans; D007422:Intestines / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care / Q000379:methods; D012004:Rectal Neoplasms / Q000601:surgery*; D054047:Surgical Stomas; D013529:Surgical Wound Dehiscence
chemical_list: D002400:Cathartics