Plasmodium cynomolgi: gametocytocidal activity of the anti-malarial compound CDRI 80/53 (elubaquine) in rhesus monkeys.
The gametocytocidal action of a new enamine analogue of primaquine, elubaquine (compound CDRI 80/53, bulaquine), has been evaluated against Plasmodium cynomolgi B in rhesus monkeys. Colony bred Anopheles stephensi mosquitoes were fed on gametocyte carrying rhesus monkeys prior to and at varying intervals after oral administration of a single dose of elubaquine at doses ranging between 0.63 and 5.00 mg/kg. Complete loss of oocyst development and mosquito infectivity was observed within 24 h after administering a single 1.25 mg/kg dose, while higher dose of 3.75 mg/kg inhibited oocyst development within 5 h, indicating gametocytocidal action of the compound. Elubaquine did not show any action against developing oocysts in the vector.
Puri
S K
SK
Division of Parasitology, Central Drug Research Institute, Lucknow 226001, India. skpuricdri@yahoo.co.in
Dutta
G P
GP
D000818:Animals; D000852:Anopheles / Q000469:parasitology; D000962:Antimalarials / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D007303:Insect Vectors / Q000469:parasitology; D008253:Macaca mulatta; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D016789:Plasmodium cynomolgi / Q000187:drug effects*; D011319:Primaquine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
D000962:Antimalarials; D011319:Primaquine; C063469:bulaquine