title: Impaired antiatherogenic function of high-density lipoproteins in the presence of various risk factors for coronary heart disease.
abstract: We studied acception of cholesterol from Fu5AH hepatoma cells by blood serum from subjects with normal level of high-density lipoprotein cholesterol and hyperlipidemia (alone or in combination with other risk factors for coronary heart disease). Cholesterol-binding activity of high-density lipoproteins decreased in subjects with hyperlipidemia alone or in combination with excess body weight and/or arterial hypertension. Impairment of high-density lipoprotein activity was associated with changes in their phospholipid composition.
authors: Department of Metabolic Disorders, State Research Center for Preventive Medicine, Russian Ministry of Health, Moscow. aserdyuk@gnicpm.ru
authors: A P
authors: AP
authors: Serdyuk
authors: I N
authors: IN
authors: Ozerova
authors: T V
authors: TV
authors: Kamyshova
authors: N V
authors: NV
authors: Perova
authors: V A
authors: VA
authors: Metel'skaya
mesh_terms: D000328:Adult; D001794:Blood Pressure; D015992:Body Mass Index; D001835:Body Weight; D006528:Carcinoma, Hepatocellular / Q000378:metabolism; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood / Q000378:metabolism*; D003327:Coronary Disease / Q000097:blood / Q000209:etiology* / Q000517:prevention & control*; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D008113:Liver Neoplasms / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014407:Tumor Cells, Cultured; D014505:Urban Population
chemical_list: D008076:Cholesterol, HDL; D002784:Cholesterol