Preimplantation genetic diagnosis in assisted reproduction.
Despite its novelty, preimplantation genetic diagnosis has become an alternative to traditional prenatal diagnosis, allowing the establishment of only unaffected pregnancies and avoiding the risk of pregnancy termination. In addition, preimplantation genetic diagnosis is presently applied for much wider indications than prenatal diagnosis, including common diseases with genetic predisposition and preimplantation human leukocyte antigen typing, with the purpose of establishing potential donor progeny for stem cell treatment of siblings. Many hundreds of apparently healthy, unaffected children have been born after preimplantation genetic diagnosis, presenting evidence of its accuracy, reliability and safety. Preimplantation genetic diagnosis appears to be of special value for avoiding age-related aneuploidies in patients of advanced reproductive age, improving reproductive outcome, particularly obvious from their reproductive history, and is presently an extremely attractive option for carriers of balanced translocations to have unaffected children of their own.
Kuliev
Anver
A
Reproductive Genetics Institute, 2825 North Halsted Street, Chicago, IL 60657, USA. anverkuliev@hotmail.com
Verlinsky
Yury
Y
D004622:Embryo, Mammalian / Q000196:embryology / Q000378:metabolism; D005260:Female; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D009865:Oocytes / Q000378:metabolism; D011247:Pregnancy; D019836:Preimplantation Diagnosis / Q000379:methods*; D015203:Reproducibility of Results; D027724:Reproductive Techniques, Assisted