title: Severe toxicity following induction chemotherapy for acute myelogenous leukemia in a patient with Werner's syndrome.
abstract: Werner's syndrome is an autosomal recessive disorder resulting in premature aging. Most patients die in their fifth decade from malignancies or heart disease. The gene for Werner's syndrome (WRN) encodes a recQ helicase. Cells from patients with Werner's syndrome have increased sensitivity to DNA-damaging drugs in vitro. Here we present a patient with Werner's syndrome who developed severe chemotherapy-induced toxicity during treatment for acute myelogenous leukemia. We propose that lack of WRN resulted in increased sensitivity of the patient's cells to the toxicity of chemotherapy.
authors: Zalmen A. Arlin Cancer Institute, New York Medical College, Valhalla, NY 10595, USA. Karen_Seiter@nymc.edu
authors: Karen
authors: K
authors: Seiter
authors: Anila
authors: A
authors: Qureshi
authors: Delong
authors: D
authors: Liu
authors: Patricia
authors: P
authors: Galvin-Parton
authors: Muhammad
authors: M
authors: Arshad
authors: Glen
authors: G
authors: Agoliati
authors: Tauseef
authors: T
authors: Ahmed
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D003561:Cytarabine / Q000008:administration & dosage; D004265:DNA Helicases / Q000235:genetics; D005047:Etoposide / Q000008:administration & dosage; D005090:Exodeoxyribonucleases; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000188:drug therapy* / Q000201:enzymology; D008297:Male; D008942:Mitoxantrone / Q000008:administration & dosage; D053484:RecQ Helicases; D014898:Werner Syndrome / Q000150:complications / Q000188:drug therapy* / Q000201:enzymology; D000071657:Werner Syndrome Helicase
chemical_list: D003561:Cytarabine; D005047:Etoposide; D008942:Mitoxantrone; D005090:Exodeoxyribonucleases; D004265:DNA Helicases; D053484:RecQ Helicases; C098785:WRN protein, human; D000071657:Werner Syndrome Helicase