title: Influence of parental SUD and ADHD on ADHD in their offspring: preliminary results from a pilot-controlled family study.
abstract: As part of a pilot-controlled family-based study of the children of parents with and without substance use disorders (SUD), the influence of parental SUD and ADHD on the risk for ADHD in offspring was evaluated. Using structured psychiatric interviews, 96 families (183 youth; mean age 11.6 years) were assessed. To evaluate the effect of parental ADHD and SUD, the offspring were stratified into four groups based on parental status: children of parents with neither ADHD nor SUD, children of parents with SUD only, children of parents with ADHD only, and children of parents with both ADHD and SUD. Using generalized estimating equation models, parental SUD and ADHD were used to predict ADHD in the offspring. The rate of children with ADHD increased among children of parents with neither disorder (3%), children of parents with SUD (13%), children of parents with ADHD (25%), and children of parents with both ADHD and SUD (50%) (p = .001). Children of parents with ADHD or ADHD plus SUD were more likely to have ADHD in comparison to children of parents with neither diagnosis (p < 0.05). Children of parents with ADHD plus SUD were at greater risk of ADHD in comparison to children of parents with SUD only (p = 0.01). Despite the small sample size, the results of this study seem to suggest that the offspring of SUD or ADHD parents are at elevated risk for ADHD compared to controls. The offspring of parents with both ADHD and SUD appear to be at the highest risk for ADHD, highlighting the need for careful screening of this group of youth for ADHD. Replication studies clarifying the nature and strength of the association are necessary.
authors: Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA. twilens@partners.org
authors: Timothy E
authors: TE
authors: Wilens
authors: Amy L
authors: AL
authors: Hahesy
authors: Joseph
authors: J
authors: Biederman
authors: Elizabeth
authors: E
authors: Bredin
authors: Sarah
authors: S
authors: Tanguay
authors: Anne
authors: A
authors: Kwon
authors: Stephen V
authors: SV
authors: Faraone
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D016241:Child of Impaired Parents; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D010865:Pilot Projects; D012307:Risk Factors; D012737:Sex Factors; D012931:Social Environment; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*