Voltammetric behavior and assay of the antibiotic drug cefazolin sodium in bulk form and pharmaceutical formulation at a mercury electrode.
The electrochemical behavior of the antibiotic drug cefazolin sodium (CFZ) in Britton-Robinson buffers (pH 2-11) at the mercury electrode was studied by means of dc-polarography, cyclic voltammetry, controlled-potential coulometry and square-wave adsorptive stripping voltammetry techniques. A validated square-wave adsorptive cathodic stripping voltammetric procedure was described for the trace determination of cefazolin in bulk form up to limits of detection and quantitation of 2.6 x 10(-10)M and 8.6 x 10(-10)M, respectively. The method was successfully applied for determination of cefazolin in pharmaceutical preparation without the necessity for samples pretreatment or any time-consuming extraction or evaporation steps prior to the analysis.
El-Desoky
H S
HS
Chemistry Department, Faculty of Science, Tanta University, 31527-Tanta, Egypt. hseldesoky@hotmail.com
Ghoneim
E M
EM
Ghoneim
M M
MM
D000900:Anti-Bacterial Agents / Q000032:analysis*; D002437:Cefazolin / Q000032:analysis*; D002626:Chemistry, Pharmaceutical; D004563:Electrochemistry; D004566:Electrodes; D006863:Hydrogen-Ion Concentration; D007267:Injections; D008628:Mercury; D019999:Pharmaceutical Solutions; D011048:Polarography; D012015:Reference Standards; D015203:Reproducibility of Results
D000900:Anti-Bacterial Agents; D019999:Pharmaceutical Solutions; D008628:Mercury; D002437:Cefazolin