The role of allogeneic stem-cell transplantation in Hodgkin's disease.
The role of allogeneic stem cell transplantation is still controversial. Early results of allogeneic bone marrow transplantation after conventional conditioning indicated high transplant-related mortality (TRM) (> 50%) and disappointing survival (< 20%). The introduction of reduced-intensity conditioning (RIC) prior to transplantation has reduced TRM. Unfortunately graft-vs.-host disease, relapse rates and survival have not substantially changed. Modifications of allogeneic transplantation in patients with Hodgkin's disease should be restricted to prospective trials.
Schmitz
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Hämatologische Abteilung, Allgemeines Krankenhaus St. Georg, Hamburg, Germany. Norbert.Schmitz@ak-stgeorg.lbk-hh.de
Sureda
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D018572:Disease-Free Survival; D006086:Graft vs Host Disease / Q000517:prevention & control; D006689:Hodgkin Disease / Q000628:therapy*; D012008:Recurrence; D033581:Stem Cell Transplantation; D019172:Transplantation Conditioning / Q000379:methods; D014184:Transplantation, Homologous