Development of a chipscale integrated microelectrode/microelectronic device for brain implantable neuroengineering applications.
An ultralow power analog CMOS chip and a silicon based microelectrode array have been fully integrated to a microminiaturized "neuroport" for brain implantable neuroengineering applications. The CMOS integrated circuit (IC) includes preamplifier and multiplexing circuitry, and a hybrid flip-chip bonding technique was developed to fabricate a functional, encapsulated microminiaturized neuroprobe device. Our neuroport has been evaluated using various methods, including pseudospike detection and local excitation measurement, and showed suitable characteristics for recording neural activities. As a proof-of-concept demonstration, we have measured local field potentials from thalamocortical brain slices of rats, suggesting that the new neuroport can form a prime platform for the development of a microminiaturized neural interface to the brain in a single implantable unit. An alternative power delivery scheme using photovoltaic power converter, and an encapsulation strategy for chronic implantation are also discussed.
Song
Yoon-Kyu
YK
Division of Engineering, Brown University, Providence, RI 02912, USA. yoon-kyu_song@brown.edu
Patterson
William R
WR
Bull
Christopher W
CW
Beals
Joseph
J
Hwang
Naejye
N
Deangelis
Andrew P
AP
Lay
Christopher
C
McKay
J Lucas
JL
Nurmikko
Arto V
AV
Fellows
Matthew R
MR
Simeral
John D
JD
Donoghue
John P
JP
Connors
Barry W
BW
D000200:Action Potentials / Q000502:physiology*; D000669:Amplifiers, Electronic; D000818:Animals; D001698:Biomedical Engineering / Q000295:instrumentation / Q000379:methods; D001921:Brain / Q000502:physiology*; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000295:instrumentation* / Q000379:methods; D004582:Electronics, Medical / Q000295:instrumentation / Q000379:methods; D019544:Equipment Failure Analysis; D008839:Microelectrodes; D008904:Miniaturization / Q000379:methods; D009474:Neurons / Q000502:physiology*; D019736:Prostheses and Implants; D011474:Prosthesis Design; D051381:Rats; D018511:Systems Integration; D014584:User-Computer Interface