Association study between the D10S1423 microsatellite marker and Alzheimer's disease.
Several studies have reported conflicting results concerning the genetic association between Alzheimer's disease (AD) and the microsatellite marker D10S1423 on chromosome 10p12-14. In an ethnically homogeneous German population of 422 patients with AD and 254 cognitively healthy controls, the 238-bp allele of the D10S1423 marker showed a weak, but after correction for multiple testing no longer significant association with AD (p = 0.015, uncorrected; p = 0.11, corrected). These findings do not support the presence of a relevant susceptibility locus for AD on chromosome 10p12-14.
Gohlke
H
H
Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universität München (TUM), Ismaningerstr. 22, D-81675 Munich, Germany.
Illig
T
T
Klopp
N
N
Wagenpfeil
S
S
Konta
L
L
Laws
S M
SM
Kurz
A
A
Riemenschneider
M
M
D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats
D053327:Apolipoprotein E4; D001057:Apolipoproteins E