Artificial peptide-nanospheres self-assembled from three-way junctions of beta-sheet-forming peptides.
Rational design of self-assembly of proteins, which plays pivotal roles in biology, is an important subject for biotechnology and also bottom-up nanotechnology. This paper has proposed a novel strategy for construction of artificial peptide-nanospheres by self-assembly. Mimicking formation of spherical viruses and clathrin, we designed a novel C3-symmetric peptide conjugate bearing three beta-sheet-forming peptides. These peptide conjugates formed antiparallel beta-structures and self-assembled into nanospheres with the size of about 20 nm in the acidic solution.
Matsuura
Kazunori
K
Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Hakozaki 6-10-1, Higashi-ku, Fukuoka 812-8581, Japan. ma14tcm@mbox.nc.kyushu-u.ac.jp
Murasato
Kazuya
K
Kimizuka
Nobuo
N
D002942:Circular Dichroism; D018625:Microscopy, Atomic Force; D008958:Models, Molecular; D043942:Nanotubes / Q000737:chemistry*; D009842:Oligopeptides / Q000737:chemistry*; D017433:Protein Structure, Secondary
D009842:Oligopeptides