A case of ovarian hyperstimulation syndrome associated with the methylenetetrahydrofolate reductase mutation gene.
OBJECTIVE
To report a case of ovarian hyperstimulation syndrome with methylenetetrahydrofolate reductase (MTHFR) gene 677T homozygosis mutation and A1298C gene heterozygosis mutation.


METHODS
Case report.


METHODS
A pregnant woman in an academic hospital.


METHODS
A woman with ovarian hyperstimulation syndrome.


METHODS
Nadroparin was administered for 2 weeks at a dosage of 200 IU/kg twice per day and then once per day; also administered once per day were folates, 5 mg; B6 vitamin, 15 mg; and B12 vitamin, 1 mg.


METHODS
Clinical follow-up.


RESULTS
Delivery was regular within the set time limits, and the fetus was born alive and in good health.


CONCLUSIONS
We believe that MTHFR mutation research could be executed in women before ovarian stimulation treatment, but other observations are necessary to support this recommendation.
Ferrara
Filippo
F
Division of Angiology, University Medical Hospital, Palermo, Italy. f_ferrara@virgilio.it
Meli
Francesco
F
Amato
Corrado
C
Cospite
Valentina
V
Raimondi
Francesco
F
Novo
Salvatore
S
D000328:Adult; D005260:Female; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D009154:Mutation; D016471:Ovarian Hyperstimulation Syndrome / Q000201:enzymology* / Q000235:genetics*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000201:enzymology* / Q000235:genetics*
D042965:Methylenetetrahydrofolate Reductase (NADPH2)