Lindane-induced immunological alterations in human poisoning cases.
OBJECTIVE
Evaluation of immunological alterations in the blood of human lindane poisoning cases.


METHODS
Serum IgG, IgM, IgA, IgE, IL-2, IL-4, TNF-alpha, and IFN-gamma levels were measured using immunoassay in 20 human cases of lindane poisoning. The presence of lindane in blood was confirmed by HPLC.


RESULTS
Serum IL-2, IL-4, and TNF-alpha levels were significantly raised with decrease in IFN-gamma levels in the lindane-exposed cases. Immunoglobulin levels were not altered.


CONCLUSIONS
The results suggest that lindane exposure at chronically high levels affects cytokine levels in humans and indicates the severity of immunotoxicity.
Seth
Vandana
V
Department of Biochemistry, Environmental Biochemistry Laboratory, UCMS & G.T.B. Hospital, Dilshad Garden, Delhi-110 095, India.
Ahmad
Rafat S
RS
Suke
Sanvidhan G
SG
Pasha
Sayed T
ST
Bhattacharya
Abhijit
A
Banerjee
Basu D
BD
D000917:Antibody Formation / Q000187:drug effects*; D001556:Hexachlorocyclohexane / Q000506:poisoning*; D007109:Immunity / Q000187:drug effects*; D007136:Immunoglobulins / Q000097:blood; D007371:Interferon-gamma / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D011041:Poisoning / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D007136:Immunoglobulins; D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D015847:Interleukin-4; D001556:Hexachlorocyclohexane; D007371:Interferon-gamma