title: [The effects of inhaled nitric oxide on pulmonary vascular resistance in patients after total cavopulmonary connection].
abstract: OBJECTIVE
  To study the effects of inhaled nitric oxide (NO) on pulmonary vascular resistance in patients after total cavopulmonary connection (TCPC).
  
  
  METHODS
  Fifty-two patients after TCPC were evaluated, of them 24 patients were administered with inhaled nitric oxide in the early postoperative period. The cardiac index (CI) and pulmonary vascular resistance (PVR) were compared before and after inhaled NO.
  
  
  RESULTS
  In experimental group, after inhaled NO, partial pressure of oxygen in artery/fraction of inspired oxygen increased from 161 +/- 17 to 193 +/- 23 (t = 2.75, P < 0.01); CI from (2.86 +/- 0.24) L.min(-1).m(-2) to (3.13 +/- 0.22) L.min(-1).m(-2) (t = 2.25, P < 0.05); PVR decreased from (4.2 +/- 0.5) U/m(2) to (3.8 +/- 1.4) U/m(2) (t = 2.29, P < 0.05); central venous pressure (CVP) from (17.0 +/- 1.8) mm Hg to (15.0 +/- 1.1) mm Hg, decreased 11.7%. Compared with the control group, respirator time decreased from (86 +/- 27) h to (54 +/- 18) h (t = 2.29, P < 0.05); ICU time from (6 +/- 2) d to (4 +/- 2) d (t = 2.32, P < 0.05); But hydrothorax drainage and length of stay had no significant difference.
  
  
  CONCLUSIONS
  Though inhaled NO, there is no significant long-term effects in patients after TCPC, but it may play an important role in the management of low cardiac output syndrome and high cava pressure caused by reactive elevated pulmonary vascular resistance in the early postoperative period of TCPC.
authors: Department of Cardiovascular Surgery, General Hospital of Shenyang Command, Shenyang 110016, China.
authors: Zong-tao
authors: ZT
authors: Yin
authors: Hong-yu
authors: HY
authors: Zhu
authors: Ren-fu
authors: RF
authors: Zhang
authors: Nan-bin
authors: NB
authors: Zhang
authors: Zeng-wei
authors: ZW
authors: Wang
authors: Han-dong
authors: HD
authors: Gong
authors: Jun
authors: J
authors: Wang
authors: Heng-chang
authors: HC
authors: Song
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D001166:Arteriovenous Shunt, Surgical / Q000379:methods*; D002302:Cardiac Output / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000008:administration & dosage / Q000627:therapeutic use*; D011184:Postoperative Period; D011651:Pulmonary Artery / Q000502:physiology / Q000601:surgery*; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D014684:Venae Cavae / Q000601:surgery*
chemical_list: D014665:Vasodilator Agents; D009569:Nitric Oxide