title: Helicobacter pylori infection in patients with haemophilia in Poland: prevalence and risk of upper gastrointestinal bleeding.
abstract: Infection with Helicobacter pylori is the main aetiological factor for erosive gastritis and duodenal or gastric peptic ulcers often complicated with life-threatening bleeding in patients with coagulation disorders. The aim of this prospective study was to evaluate the prevalence of Helicobacter pylori infection in haemophilia patients, and to assess the risk of gastrointestinal bleeding associated with this infection. From 2000 to 2002, 146 patients with haemophilia (129, haemophilia A; 13, haemophilia B), mean age, 39.9 years (+/-7.3), were investigated for H. pylori infection using IgG and IgA latex serological test. The control group included 100 men with no coagulation disorders, mean age, 40.9 years (+/-9.2). For 72 (49.3%) patients with haemophilia and 39 controls (39.0%) serological tests were positive indicating the presence of H. pylori infection (P =0.1112). A history of gastrointestinal bleeding was reported in 46 patients (31.5%) with haemophilia and in two control group patients (2.0%) (P < 0.0001). Gastrointestinal bleeding was significantly more frequent in patients with haemophilia infected with H. pylori (33/46; 71.7%) than in patients with no H. pylori infection (13/46; 28.3%; P = 0.0002). In conclusion, the prevalence of H. pylori infection in haemophilic patients in Poland is comparable with that in patients with no coagulation disorders. Helicobacter pylori infection is a risk factor for duodenal and gastric ulcer bleeding in haemophilia patients. In view of the high frequency of upper gastrointestinal bleeding associated with H. pylori infection, we believe that screening and eradication therapy are appropriate in haemophilia patients.
authors: Department of Surgery, Institute of Haematology and Blood Transfusion, Warsaw, Poland. andrzejszczepanik@go2.pl
authors: A B
authors: AB
authors: Szczepanik
authors: M
authors: M
authors: Zaleska
authors: A
authors: A
authors: Wiszniewski
authors: S
authors: S
authors: Wislawski
authors: A
authors: A
authors: Misiak
authors: R
authors: R
authors: Maryniak
authors: J
authors: J
authors: Windyga
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000276:immunology; D006471:Gastrointestinal Hemorrhage / Q000453:epidemiology* / Q000209:etiology; D016481:Helicobacter Infections / Q000150:complications / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000276:immunology*; D006467:Hemophilia A / Q000150:complications / Q000453:epidemiology*; D002836:Hemophilia B / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D008297:Male; D011044:Poland / Q000453:epidemiology; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D000907:Antibodies, Bacterial