Intraocular peripheral nerve sheath tumor in a dog.
A tumor within the right globe in a 9-year-old Shetland sheepdog was examined pathologically. The tumor was composed of spindle or oval cells arranged in interwoven bundles with intervening collagenous or mucinous matrices. Immunohistochemically, the tumor bound antibody directed to S-100 protein and vimentin, but not to desmin, actin smooth muscle, or neurofilament. Electron microscopy revealed that the tumor cells had poorly developed cytoplasmic processes, desmosomes between closely contiguous cells, and a discontinuous basement membrane-like material. Based on these findings, the tumor was diagnosed as a peripheral nerve sheath tumor (PNST) histologically. To the authors' knowledge, this is the first reported case of intraocular PNST in dogs.
Sato
Tsuneo
T
Laboratory of Veterinary Pathology, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fjisawa, Kanagawa 252-8510, Japan.
Yamamoto
Atsuko
A
Shibuya
Hisashi
H
Sudo
Hiroshi
H
Shirai
Wataru
W
Amemori
Takashi
T
D000818:Animals; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D004285:Dogs; D015353:Eye Enucleation / Q000662:veterinary; D005134:Eye Neoplasms / Q000175:diagnosis / Q000662:veterinary*; D008297:Male; D010524:Peripheral Nervous System Neoplasms / Q000175:diagnosis / Q000662:veterinary*; D014057:Tomography, X-Ray Computed / Q000662:veterinary