title: Prevalence of prednisolone (non)compliance in adult liver transplant recipients.
abstract: Limited evidence is available concerning (non)compliance with the immunosuppressive regimen in adult liver transplant recipients. In our study we prospectively assessed prednisolone (non)compliance in 108 adult liver transplant recipients using electronic event monitoring (EEM) in an outpatient setting. The EEM is a pill bottle fitted with a cap containing a microelectronic circuit that registers date and time of bottle openings and closings. Median taking compliance was 100% (range 60-105%), median dosing compliance was 99% (range 58-100%); median timing compliance (TIC) was 94% (42-100%). A drug holiday (DH) of > or =48 h was found in 39% of the patients of > or =72 h in 16% of the patients. Using EEM in liver transplant recipients, we found an overall high level of compliance for prednisolone, except that TIC was low in about one third of the patients. Age below 40 years was found a significant risk factor for decreased TIC and for DHs of > or =48 h.
authors: Department of Gastroenterology and Hepatology, University Hospital Groningen, The Netherlands. g.drent@int.azg.nl
authors: Gerda
authors: G
authors: Drent
authors: Elizabeth B
authors: EB
authors: Haagsma
authors: Sabina De
authors: SD
authors: Geest
authors: Aad P
authors: AP
authors: van den Berg
authors: Els M
authors: EM
authors: Ten Vergert
authors: Hillegonda J
authors: HJ
authors: van den Bosch
authors: Maarten J H
authors: MJ
authors: Slooff
authors: Jan H
authors: JH
authors: Kleibeuker
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D004582:Electronics, Medical; D005260:Female; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D011239:Prednisolone / Q000008:administration & dosage*; D015995:Prevalence
chemical_list: D011239:Prednisolone