title: [Fluoride tolerance in cases of dental caries and fluorosis].
abstract: 32 volunteers (18-20-year-olds) without concomitant diseases were divided into 3 groups: with high caries incidence (1), with dental fluorosis of different degrees (2) and with completely intact dentition (3). Dynamics of ionized F in blood serum and mixed saliva after single sodium fluoride burden (F-dosage=0.1 mg/kg body weight) was determined 1, 2, 3, 5, 7 and 24 hours after per os consumption by Orion-9609-BN F-selective electrode. F bound by organic material was assayed after breaking covalent bond C-F by sodium diphenyl. It was common for all participants that wide range of sensitivity to ingested F but F-tolerance had reversed trends in caries and fluorosis. Content of organic "fluoride" in blood serum changed insignificantly. In mixed saliva the dynamics of ionized F in dental caries and fluorosis conditions followed to some extent blood serum trends.
authors: B N
authors: BN
authors: Davydov
authors: Iu N
authors: IuN
authors: Borinskiĭ
authors: V A
authors: VA
authors: Beliaev
mesh_terms: D000293:Adolescent; D000328:Adult; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003731:Dental Caries / Q000378:metabolism*; D004361:Drug Tolerance; D005260:Female; D005459:Fluorides / Q000097:blood; D009050:Fluorosis, Dental / Q000378:metabolism*; D006801:Humans; D008297:Male; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D002327:Cariostatic Agents; D012969:Sodium Fluoride; D005459:Fluorides