title: In vitro enzyme inhibition activities of crude ethanolic extracts derived from medicinal plants of Pakistan.
abstract: Twenty two crude ethanolic extracts from 14 indigenous medicinal plants were subjected to enzyme inhibition screening against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and lipoxygenase enzymes (LO). Three extracts showed activity against AChE, nine extracts were found to be active against BChE and four extracts inhibited the enzyme LO. The most significant inhibition activities (> or =50%) were found in extracts derived from Aloe vera (leaves), Alpinia galanga (rhizome), Curcuma longa (rhizome), Cymbopogon citratus (leaves), Ocimum americanum (leaves), Ocimum americanum (stem) and Withania somnifera (roots).
authors: Department of Chemistry, University of Peshawar, Peshawar - 25120, Pakistan. somiakhattak@yahoo.com
authors: Somia
authors: S
authors: Khattak
authors: Saeed-Ur-Rehman
authors: Hameed Ullah
authors: HU
authors: Shah
authors: Taous
authors: T
authors: Khan
authors: Manzoor
authors: M
authors: Ahmad
mesh_terms: D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D000431:Ethanol / Q000737:chemistry; D006801:Humans; D066298:In Vitro Techniques; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology; D010154:Pakistan; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry
chemical_list: D002800:Cholinesterase Inhibitors; D004791:Enzyme Inhibitors; D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts; D012997:Solvents; D000431:Ethanol