title: Serological correlations with nephritis in systemic lupus erythematosus.
abstract: Autoantibodies have long been thought to participate in the pathogenesis of lupus nephritis. In this regard, antibodies to double stranded (ds)DNA and ribosomal P protein have been studied the most intensively. We now report a new specificity, antibodies to lipoprotein lipase (LPL) that is strongly associated with lupus nephritis and has a powerful synergistic effect with anti-ribosomal P antibodies in its association with nephritis. The recognition of anti-LPL antibodies and their synergy with anti-P antibodies are discussed in terms of the pathogenesis of lupus nephritis.
authors: Arthritis/Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, 73104, USA. morris-reichlin@omrf.ouhsc.edu
authors: Morris
authors: M
authors: Reichlin
mesh_terms: D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D004247:DNA / Q000276:immunology; D006801:Humans; D008071:Lipoprotein Lipase / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology; D009393:Nephritis / Q000276:immunology*; D012189:Retrospective Studies; D012269:Ribosomal Proteins / Q000276:immunology
chemical_list: D001323:Autoantibodies; D012269:Ribosomal Proteins; D004247:DNA; D008071:Lipoprotein Lipase