Effect of kainate-induced experimental epilepsy on NADPH-diaphorase and calcium-binding proteins in rat hippocampal neurons.
Experimental epilepsy induced in rats by infusion of kainic acid into the lateral cerebral ventricles decreased the number of NADPH-diaphorase-positive neurons in the hippocampal formation by 55-79% and increased activity of this enzyme in CA1 and CA3 pyramidal neurons. All parvalbumin-immunoreactive cells were highly resistant to the cytotoxic effects of kainate in contrast to calbindin- and calretinin-positive interneurons, whose amount decreased by 50%.
Dudina
Yu V
YV
Department of Histology, Vladivostok State Medical University. juliad@mail.primorye.ru
D000818:Animals; D064032:Calbindin 2; D064026:Calbindins; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D007150:Immunohistochemistry; D007395:Interneurons / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D007608:Kainic Acid; D009252:NADPH Dehydrogenase / Q000378:metabolism*; D017966:Pyramidal Cells / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D064030:S100 Calcium Binding Protein G / Q000032:analysis / Q000378:metabolism*
C576512:Calb2 protein, rat; D064032:Calbindin 2; D064026:Calbindins; D064030:S100 Calcium Binding Protein G; D009252:NADPH Dehydrogenase; D007608:Kainic Acid