title: Efficient synthesis of novel gamma-substituted gamma-butenolides by Lewis acid catalyzed addition of metal enolates of active methylene compounds to mucohalic acids.
abstract: Lewis acid catalyzed addition of active methylene compounds to mucochloric acid (1) and mucobromic acid (2) affording Knoevenagel aldol adducts, gamma-substituted gamma-butenolides, has been explored. Catalytic efficiencies of various Lewis acids have been compared. Indium acetate (0.25-5 mol %) was found to be the most efficient catalyst.
authors: Chemical Research and Development, Pfizer Global Research & Development, Ann Arbor Laboratories, Pfizer Inc., 2800 Plymouth Road, Ann Arbor, MI 48105, USA. ji.zhang@pfizer.com
authors: Ji
authors: J
authors: Zhang
authors: Koushik Das
authors: KD
authors: Sarma
authors: Timothy T
authors: TT
authors: Curran
authors: Daniel T
authors: DT
authors: Belmont
authors: James G
authors: JG
authors: Davidson