title: Distinct M50 and M100 auditory gating deficits in schizophrenia.
abstract: The time course of the schizophrenia auditory gating deficit may provide clues to mechanisms of impaired cognition. Magnetoencephalography was recorded during a standard paired-click paradigm. Using source strength of the M50 and M100 components for each click, calculated from dipole locations identified as underlying each component for the first click, a ratio of the second divided by the first was used to measure gating. Patients showed a left-hemisphere gating deficit in M50 and a bilateral gating deficit in M100. Hypothesizing that an early deficit may affect later processing, hierarchical regression was used to examine variance shared between the components. A left-hemisphere M100 gating deficit was coupled with the left M50 gating deficit. In contrast, a right-hemisphere M100 gating deficit was unrelated to M50 gating in either hemisphere. Investigations of interhemisphere gating relations may clarify group differences in regional connectivity and their role in gating.
authors: Center for Functional Brain Imaging, New Mexico VA Health Care System, Albuquerque, New Mexico 87108, USA.
authors: Faith M
authors: FM
authors: Hanlon
authors: Gregory A
authors: GA
authors: Miller
authors: Robert J
authors: RJ
authors: Thoma
authors: Jessica
authors: J
authors: Irwin
authors: Aaron
authors: A
authors: Jones
authors: Sandra N
authors: SN
authors: Moses
authors: Mingxiong
authors: M
authors: Huang
authors: Michael P
authors: MP
authors: Weisend
authors: Kim M
authors: KM
authors: Paulson
authors: J Christopher
authors: JC
authors: Edgar
authors: Lawrence E
authors: LE
authors: Adler
authors: Jose M
authors: JM
authors: Cañive
mesh_terms: D000328:Adult; D001307:Auditory Perception / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D015225:Magnetoencephalography; D008297:Male; D012565:Schizophrenic Psychology