title: Insulin sensitivity is impaired in patients with migraine.
abstract: Several studies have shown the presence of a comorbidity between migraine and vascular diseases, like hypertension and stroke. The mechanisms of this comorbidity are unknown. Impaired insulin sensitivity has recently emerged as a risk factor for hypertension and stroke. We evaluated insulin sensitivity in 30 young, nonobese, nondiabetic, normotensive migraine patients and in 15 healthy controls. During the OGTT, glucose plasma concentrations were significantly higher in migraineurs than in controls. Insulin sensitivity, as measured by ISI-stumvoll and OGIS-180 indexes, was significantly altered in migraine. Our data show that insulin sensitivity is impaired in migraine and suggest a role for insulin resistance in the comorbidity between migraine and vascular diseases.
authors: Neurology III-Headache Centre, Department of Neuroscience, University of Turin, Italy. irainero@molinette.piemonte.it
authors: I
authors: I
authors: Rainero
authors: P
authors: P
authors: Limone
authors: M
authors: M
authors: Ferrero
authors: W
authors: W
authors: Valfrè
authors: C
authors: C
authors: Pelissetto
authors: E
authors: E
authors: Rubino
authors: S
authors: S
authors: Gentile
authors: R
authors: R
authors: Lo Giudice
authors: L
authors: L
authors: Pinessi
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008881:Migraine Disorders / Q000150:complications*
chemical_list: D001786:Blood Glucose; D007328:Insulin