title: Efficient microwave combinatorial parallel and nonparallel synthesis of N-alkylated glycine methyl esters as peptide building blocks.
abstract: An easy and convenient microwave-assisted synthesis of N-alkylated glycine methyl esters is described. Parallel and nonparallel combinatorial methods are described and compared. The described reactions are reductive alkylations of several aldehydes and glycine methyl ester in the presence of NaBH3CN. Good yields and short reaction times are the main aspects of these procedures.
authors: Dipartimento di Chimica Farmaceutica e Tossicologica, Università di Napoli Federico II, Via D. Montesano, 49, 80131 Naples, Italy. santagad@unina.it
authors: Vincenzo
authors: V
authors: Santagada
authors: Francesco
authors: F
authors: Frecentese
authors: Elisa
authors: E
authors: Perissutti
authors: Ferdinando
authors: F
authors: Fiorino
authors: Beatrice
authors: B
authors: Severino
authors: Donatella
authors: D
authors: Cirillo
authors: Sara
authors: S
authors: Terracciano
authors: Giuseppe
authors: G
authors: Caliendo
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D005998:Glycine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D010455:Peptides; C035591:glycine methyl ester; D005998:Glycine