Changes in myocardial blood supply during experimental hypertension treated with verapamil in rabbits.
Rabbit hearts were studied at different periods of experimental arterial hypertension and its treatment with verapamil. Morphological study revealed a progressive decrease in the number of capillaries per unit mass during the development of myocardial hypertrophy in hypertensive hearts. In hypertensive animals treated with verapamil the density of capillaries in both ventricles did not decrease, but verapamil injected to intact animals sharply decreased this parameter.
Frolov
V A
VA
Department of Pathological Physiology, Russian University of People Friendship, Moscow. frolov@med.pfu.edu.ru
Drozdova
G A
GA
Rieger
P
P
Blagonravov
M
M
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology* / Q000627:therapeutic use; D002196:Capillaries / Q000187:drug effects; D006332:Cardiomegaly / Q000188:drug therapy; D006978:Hypertension, Renovascular / Q000188:drug therapy* / Q000503:physiopathology*; D008297:Male; D011817:Rabbits; D014700:Verapamil / Q000494:pharmacology* / Q000627:therapeutic use
D002121:Calcium Channel Blockers; D014700:Verapamil