title: First total synthesis of cichorine and zinnimidine.
abstract: The first total synthesis of the phytotoxins cichorine and zinnimidine is described. The synthetic tactics involve the sequential connection of the dense and diverse functionalities on the aromatic nucleus followed by a Parham cyclization process, giving rise to the lactam unit embedded in the title compound framework.
authors: UMR 8009 "Chimie Organique et Macromoléculaire", Laboratoire de Chimie Organique Physique, Bâtiment C3(2), Université des Sciences et Technologies de Lille, 59655, Villeneuve d'Ascq Cédex, France.
authors: Anne
authors: A
authors: Moreau
authors: Axel
authors: A
authors: Couture
authors: Eric
authors: E
authors: Deniau
authors: Pierre
authors: P
authors: Grandclaudon
authors: Stéphane
authors: S
authors: Lebrun
mesh_terms: D007211:Indoles / Q000138:chemical synthesis*; D054833:Isoindoles; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D014118:Toxins, Biological / Q000138:chemical synthesis*
chemical_list: D007211:Indoles; D054833:Isoindoles; D014118:Toxins, Biological; C504968:cichorine; C504969:zinnimidine