Effects of vitamin supply on spontaneous and chemically induced mutagenesis in human cells.
Chromosome aberrations in donor peripheral blood lymphocyte culture were evaluated before, 14 and 30 days after treatment with a vitamin/mineral complex. Treatment with the complex had no effect on spontaneous level of aberrant cells. The number of chromosome aberrations induced by dioxidine or cadmium chloride in vitro at the G2 stage decreased on days 14 and 30 of treatment with the complex.
Sidneva
E S
ES
Medical Genetic Research Center, Russian Academy of Medical Sciences, Moscow. eksidneva@mtu-net.ru
Katosova
L D
LD
Platonova
V I
VI
Beketova
N A
NA
Kodentsova
V M
VM
Chebotarev
A N
AN
Durnev
A D
AD
Bochkov
N P
NP
D000328:Adult; D019256:Cadmium Chloride / Q000633:toxicity; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000187:drug effects*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D008297:Male; D016296:Mutagenesis; D009153:Mutagens / Q000633:toxicity; D011810:Quinoxalines / Q000633:toxicity; D014815:Vitamins / Q000008:administration & dosage / Q000494:pharmacology*
D009153:Mutagens; D011810:Quinoxalines; D014815:Vitamins; C001077:dioxidine; D019256:Cadmium Chloride