Neuroprotective activity of proproten in rats with experimental local photothrombosis of the prefrontal cortex.
Proproten (ultralow doses of antibodies to S100 protein) exhibited neuroprotective activity in rats with experimental photochemical thrombosis of the prefrontal cortex. Proproten was more potent than standard neuroprotectors piracetam and vinpocetine in alleviating the signs of memory disorders produced by ischemic injury. Pathomorphological study of the damaged area confirmed the neuroprotective effect of Proproten.
Romanova
G A
GA
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Russia.
Voronina
T A
TA
Dugina
Yu L
YL
Martyushev-Poklad
A V
AV
Sergeeva
S A
SA
Epstein
O I
OI
Barskov
I V
IV
D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010777:Photochemistry; D017397:Prefrontal Cortex / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D009418:S100 Proteins / Q000276:immunology*; D013927:Thrombosis / Q000517:prevention & control*
D000906:Antibodies; D018696:Neuroprotective Agents; D009418:S100 Proteins