Antibacterial activities and bonding of MMSA/TBB resin containing amphiphilic lipids.
The purpose of this study was to investigate the antibacterial activity of MMA/TBB resin containing newly developed amphiphilic lipids. The amphiphilic lipids, C10-L-Ala/pts and C12-L-Ala/pts, synthesized from the reaction of n-alkyl alcohol and L-alanine were dissolved in MMA at concentrations of 0.5, 1.0, 1.5, and 2.0 mol%. Resin mixtures of PMMA powder and each MMA liquid containing lipid and TBB were prepared for all tests. Both lipids gave antibacterial effect to MMA/ TBB resin. The addition of C12-L-Ala/pts to MMA resulted in a significantly higher antibacterial activity than the addition of C10-L-Ala/pts. In terms of bond strength, the bond strength of MMA/TBB resin to bovine dentin was significantly decreased by the addition of amphiphilic lipids. But for enamel, the bond strength of MMA/TBB resin with amphiphilic lipids was clinically acceptable for orthodontic brackets. In conclusion, amphiphilic lipids will be useful as a component of adhesive resin to give the latter an antibacterial effect.
Kazuno
Taichi
T
Department of Oral Growth and Development, Orthodontics Section, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, Japan. kazuno@ctb.ne.jp
Fukushima
Tadao
T
Hayakawa
Tohru
T
Inoue
Yusuke
Y
Ogura
Rieko
R
Kaminishi
Hidenori
H
Miyazaki
Koji
K
D000180:Acrylic Resins; D000409:Alanine / Q000737:chemistry; D000704:Analysis of Variance; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001896:Boron Compounds; D002175:Candida / Q000187:drug effects; D002417:Cattle; D001840:Dental Bonding; D003743:Dental Enamel; D003804:Dentin; D007851:Dodecanol / Q000737:chemistry; D005233:Fatty Alcohols / Q000737:chemistry; D008055:Lipids / Q000737:chemistry*; D008422:Materials Testing; D020366:Methylmethacrylate; D019279:Resin Cements / Q000737:chemistry / Q000494:pharmacology*; D033081:Shear Strength; D013295:Streptococcus mutans / Q000187:drug effects; D016986:Streptococcus sobrinus / Q000187:drug effects; D013501:Surface-Active Agents / Q000737:chemistry / Q000494:pharmacology*
D000180:Acrylic Resins; D000900:Anti-Bacterial Agents; D001896:Boron Compounds; D005233:Fatty Alcohols; D008055:Lipids; D019279:Resin Cements; D013501:Surface-Active Agents; C009523:tri-n-butylborane; D007851:Dodecanol; D020366:Methylmethacrylate; C031172:4-META resin; C029383:n-decyl alcohol; D000409:Alanine