Ischemic tolerance in the brain.
Endogenous tolerance to cerebral ischemia is nature's strategy for neuroprotection. Exploring the physiologic and molecular mechanism of this phenomenon may give us new means of protection against ischemia and other degenerative disorders. This article reviews the currently available experimental methods to induce ischemic tolerance in the brain and gives a brief summary of the potential mode of action.
Kapinya
K J
KJ
Department of Experimental Neurology, Medical Faculty Charité, Humboldt-University, Berlin, Germany. kapinyak@comcast.com
D000222:Adaptation, Physiological; D000818:Animals; D001921:Brain / Q000098:blood supply*; D002545:Brain Ischemia / Q000503:physiopathology*; D016923:Cell Death; D015870:Gene Expression; D005849:Gerbillinae; D019194:Ischemic Preconditioning; D020935:MAP Kinase Signaling System / Q000502:physiology; D051379:Mice; D051381:Rats; D014157:Transcription Factors / Q000502:physiology
D014157:Transcription Factors