Palladium-catalyzed asymmetric hydrogenation of functionalized ketones.
[reaction: see text]. A novel catalytic system for asymmetric hydrogenation of functionalized ketones has been developed using a Pd/bisphosphine complex as the catalyst in 2,2,2-trifluoroethanol. The reaction exhibits high enantioselectivity, and up to 92.2% ee was obtained.
Wang
You-Qing
YQ
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian.
Lu
Sheng-Mei
SM
Zhou
Yong-Gui
YG