title: Relationship between the Arg72Pro polymorphism of p53 and outcome for patients with traumatic brain injury.
abstract: OBJECTIVE
  To determine the relationship between the Arg72Pro polymorphism of p53 and the outcome after traumatic brain injury (TBI) in humans.
  
  
  METHODS
  A prospective study was carried out in a ten-bed surgical intensive care unit (SICU) of a university hospital.
  
  
  METHODS
  The study included 90 caucasian patients who had experienced a severe TBI within the previous 24 h. The exclusion criterion was a previous deficit in the central nervous system.
  
  
  RESULTS
  The main recorded outcomes were values on the Glasgow Outcome Scale (GOS) at discharge from the SICU (GOS-0) and 6 months later (GOS-6). A blood sample was taken from each patient and all samples were analyzed by an allele-specific polymerase chain reaction for detection of Arg72Pro polymorphism of p53. These polymorphisms were tested for their association with values of GOS-0 and GOS-6. A two-tailed value of p<0.05 was considered statistically significant. The frequency of the argine/argine (Arg/Arg) genotype was greater among the patients who had a bad outcome at GOS-0 (69 vs 31% in the bad-outcome group; p=0.029). A multiple logistic regression analysis showed that patients with the Arg/Arg variation had a 2.9-fold greater risk of having a bad outcome at discharge from the SICU (95% confidence interval, 1.05-8.31; p=0.039 ). There was no similar relationship with respect to GOS-6.
  
  
  CONCLUSIONS
  The Arg/Arg genotype of the Arg72Pro polymorphism in p53 is associated with increased likelihood of a bad outcome at discharge from the SICU.
authors: Department of Anaesthesia, General University Hospital, C/ Hermanos Falcó 37, 02006, Albacete, Spain.
authors: Pascual
authors: P
authors: Martínez-Lucas
authors: Jerónimo
authors: J
authors: Moreno-Cuesta
authors: Dolores C
authors: DC
authors: García-Olmo
authors: Francisco
authors: F
authors: Sánchez-Sánchez
authors: Julio
authors: J
authors: Escribano-Martínez
authors: Ana Cuartero
authors: AC
authors: del Pozo
authors: Máxima
authors: M
authors: Lizán-García
authors: Damián
authors: D
authors: García-Olmo
mesh_terms: D018806:APACHE; D000328:Adult; D001930:Brain Injuries / Q000145:classification / Q000235:genetics* / Q000401:mortality; D004151:Dipeptides / Q000235:genetics*; D005260:Female; D016158:Genes, p53 / Q000235:genetics*; D005838:Genotype; D006801:Humans; D015601:Injury Severity Score; D007362:Intensive Care Units; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011237:Predictive Value of Tests; D011446:Prospective Studies; D013030:Spain
chemical_list: D004151:Dipeptides; C076685:arginylarginine; C039357:arginylproline