Effects of pneumatic dilation and myotomy on esophageal function and morphology in patients with achalasia.
Only two treatment modalities-pneumatic dilation and Heller myotomy-promise long-term relief from dysphagia and regurgitation in patients with achalasia. The objective of this study was to determine whether both options differ in their effects on esophageal function, morphology, and improvement in symptoms. Eighty-nine patients diagnosed with achalasia between January 1980 and December 2002 at a single center were enrolled in this study. Sixty-four patients underwent pneumatic dilation and 25 Heller myotomy in combination with an anterior semifundoplication (Dor procedure). Clinical evaluation (Eckardt-Score), esophageal manometry, and barium swallow were performed before and within 6 months after treatment. Our data shows that Heller myotomy reduces the LES resting pressure more markedly (7.9 [3.7-16.9] mm Hg) than pneumatic dilation (14.5 [2.7-36.0] mm Hg) (P < 0.0001) with similar pressures at diagnosis in both groups. Morphologic changes, assessed by the diameter of the esophageal corpus, were also more pronounced after surgical therapy (P > 0.05). Both options will lead to an immediate and significant improvement in symptoms, although the two treatment modalities did not differ in their subjective results. As only objective findings, such as those obtained by manometry and the timed barium swallow, have proven relevance for the assessment of long-term results, surgical therapy is the superior and more effective treatment option in patients with achalasia.
Gockel
Ines
I
Department of General and Abdominal Surgery, Johannes Gutenberg University, Mainz, Germany. ; tDepartment of Gastroenterology, German Diagnostic Clinic, Wiesbaden, Germany.
Junginger
Theodor
T
Eckardt
Volker F
VF
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002404:Catheterization; D002637:Chest Pain / Q000503:physiopathology; D002648:Child; D003680:Deglutition Disorders / Q000503:physiopathology; D004931:Esophageal Achalasia / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D049630:Esophageal Sphincter, Lower / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D018662:Fundoplication / Q000379:methods; D005764:Gastroesophageal Reflux / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010528:Peristalsis / Q000502:physiology; D011312:Pressure; D012737:Sex Factors; D016896:Treatment Outcome