Rho proteins in cell migration and metastasis.
The ability of tumors to invade, colonize, and destroy distant organs was first recognized by Jean-Claude Recamier in 1829. He termed this phenomenon metastasis. Since it was first described, metastasis has been shown to be a complex multistep process. One important step is cell migrationa critical component of both cancer-cell invasion at the primary site (allowing cells to gain access to the vasculature) and for cells to penetrate the host tissue at distant sites. The aim of this review is to examine the fundamental role of migration in cancer progression and to discuss the role of the Rho family of small G proteins and their effectors in this process.
Titus
Brian
B
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, USA.
Schwartz
Martin A
MA
Theodorescu
Dan
D
D000209:Acute-Phase Proteins / Q000235:genetics / Q000502:physiology*; D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D015870:Gene Expression; D016147:Genes, Tumor Suppressor; D008322:Mammals; D009362:Neoplasm Metastasis / Q000235:genetics / Q000503:physiopathology*; D015398:Signal Transduction; D020741:rho GTP-Binding Proteins / Q000235:genetics / Q000502:physiology
D000209:Acute-Phase Proteins; C010781:acute-phase protein rho; D020741:rho GTP-Binding Proteins