Streptokinase increases the sensitivity of colon cancer cells to chemotherapy by gemcitabine and cis-platine in vitro.
The aim was to determine the effect of fybrinolytic therapy by streptokinase on chemotherapy and radiation response in human colon cancer cells. The cells were treated with different concentrations of gemcitabine, cis-platine and streptokinase, at a single use or in combinations. Radiation was tested at a dose 0.5, 5 and 15 Gy in three different schedules. The chemotherapy showed higher cytotoxic effect in combination with streptokinase. On the other hand, the combination of chemotherapy with streptokinase and radiotherapy provide no improvement in sensitivity of cancer cells to treatment. The data suggest that fybrinolytic therapy could influence the effect of chemotherapy.
Bobek
Vladimir
V
Department of Tumor Biology, Third Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 34, Czech Republic. vbobek@centrum.cz
Pinterova
Daniela
D
Kolostova
Katarina
K
Boubelik
Michael
M
Douglas
Joshua
J
Teyssler
Petr
P
Pavlasek
Jiri
J
Kovarik
Josef
J
D000970:Antineoplastic Agents / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects* / Q000528:radiation effects; D002945:Cisplatin / Q000494:pharmacology*; D003110:Colonic Neoplasms; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D019073:HT29 Cells; D006801:Humans; D013300:Streptokinase / Q000494:pharmacology*; D013997:Time Factors; D000093542:Gemcitabine
D000970:Antineoplastic Agents; D005343:Fibrinolytic Agents; D003841:Deoxycytidine; D013300:Streptokinase; D002945:Cisplatin; D000093542:Gemcitabine