Adiponectin and human pregnancy.
Adiponectin is an adipose tissue-derived plasma protein that is involved in regulation of insulin resistance and glucose hemostasis. Human pregnancy is characterized by an increase in insulin resistance. Therefore, it is only natural that the role of adiponectin, a modulator of insulin resistance, is subject to investigation during gestation. Furthermore, conditions associated with increased insulin resistance, such as gestational diabetes and preeclampsia, may be influenced by this hormone. Adiponectin, a key modulator of insulin action and glucose metabolism, both known to regulate fetal growth, is a plausible candidate for regulation of intrauterine fetal development. In this review, we summarize the recent studies describing the relationship between adiponectin, pregnancy, and fetal growth.
Mazaki-Tovi
Shali
S
Department of Obstetrics and Gynecology, Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel-Hashomer 52621, Israel.
Kanety
Hannah
H
Sivan
Eyal
E
D052242:Adiponectin / Q000378:metabolism / Q000502:physiology*; D001724:Birth Weight / Q000502:physiology; D003920:Diabetes Mellitus / Q000378:metabolism; D016640:Diabetes, Gestational / Q000378:metabolism; D005260:Female; D047109:Fetal Development / Q000502:physiology; D005333:Fetus; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D011225:Pre-Eclampsia / Q000378:metabolism; D011247:Pregnancy / Q000378:metabolism / Q000502:physiology*; D011254:Pregnancy in Diabetics / Q000378:metabolism
D052242:Adiponectin