title: [Soluble tumor necrosis factor related apoptosis inducing ligand (sTRAIL) and clinical outcome of HBV infection in human].
abstract: OBJECTIVE
  To explore the role of sTRAIL in the pathogenesis of HBV infection in human being.
  
  
  METHODS
  sTRAIL in 153 patients' sera was examined with ELISA. Correlations between sTRAIL and liver functional parameters were analysed.
  
  
  RESULTS
  The levels of sTRAIL in patients with various clinical types of hepatitis B as well as primary hepatocellular carcinoma were all higher than that in normal persons and became almost normal in recovering stage cases. In acute and chronic HBV infection, sTRAIL level was negatively correlated with ALT, AST and total bilirubin levels, and positively correlated with serum albumin.
  
  
  CONCLUSIONS
  The results indicated that higher level of sTRAIL expression is correlated with liver damage, and apoptosis induced by sTRAIL is one of the mechanisms of liver damage in HBV infection.
authors: Jinan Infectious Diseases Hospital, Jinan 250021, China.
authors: Feng-e
authors: FE
authors: Yue
authors: Dian-yong
authors: DY
authors: Liu
authors: Jing
authors: J
authors: Song
authors: Li-ning
authors: LN
authors: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006509:Hepatitis B / Q000097:blood*; D019694:Hepatitis B, Chronic / Q000097:blood*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000821:virology; D008113:Liver Neoplasms / Q000097:blood / Q000821:virology; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin / Q000032:analysis; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000097:blood*; D055815:Young Adult
chemical_list: D012709:Serum Albumin; D053221:TNF-Related Apoptosis-Inducing Ligand; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase