Does circadian and seasonal variation in occurrence of acute aortic dissection influence in-hospital outcomes?
The risk of acute aortic dissection (AAD) exhibits chronobiological variations with peak onset in the morning and in winter. However, it is not known whether the time of day or season of the year of the AAD affects clinical outcomes. We studied 1,032 patients enrolled in the International Registry of Acute Aortic Dissection from January 1997 to December 2001. For circadian and seasonal analysis, the time and date of symptom onset were available for 741 and 1,007 patients, respectively, and were grouped into four 6h periods (morning, afternoon, evening, and night) and four seasons (winter, spring, summer, and autumn). The chi2 test for goodness of fit was used to evaluate non-uniformity of the time of day and time of year for critical in-hospital clinical events, including death. While highest incidence of AAD occurred in the morning and winter, clinical events (including mortality) were similar during the four different periods of the 24 h (chi2 = 1.9, p = 0.60) and seasonal (chi2 = 1.2, p = 0.75) periods.
Mehta
Rajendra H
RH
Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA. mehta007@dcri.duke.edu
Manfredini
Roberto
R
Bossone
Eduardo
E
Hutchison
Stuart
S
Evangelista
Arturo
A
Boari
Benedetta
B
Cooper
Jeanna V
JV
Smith
Dean E
DE
O'Gara
Patrick T
PT
Gilon
Dan
D
Pape
Linda A
LA
Nienaber
Christoph A
CA
Isselbacher
Eric M
EM
Eagle
Kim A
KA
D000368:Aged; D000784:Aortic Dissection / Q000473:pathology* / Q000628:therapy; D001683:Biological Clocks; D002909:Chronobiology Phenomena; D002940:Circadian Rhythm; D005260:Female; D006761:Hospitals; D006801:Humans; D008297:Male; D008875:Middle Aged; D012621:Seasons; D013997:Time Factors; D016896:Treatment Outcome