A model of muscle atrophy using cast immobilization in mice.
We describe a new cast-immobilization protocol to induce muscle atrophy in the lower hindlimb muscles of mice. Bilateral cast immobilization for 2 weeks in a shortened position resulted in a significant loss of muscle size and strength in the soleus and extensor digitorum longus. The availability of a model of cast immobilization in mice may benefit future studies targeting genetic or cell therapy interventions of muscle atrophy in transgenic and mutant mice strains.
Frimel
Tiffany N
TN
Brain Rehabilitation Research Center, Malcom Randall Department of Veterans Affairs Medical Center, Gainesville, Florida, USA.
Kapadia
Fatema
F
Gaidosh
Gabriel S
GS
Li
Ye
Y
Walter
Glenn A
GA
Vandenborne
Krista
K
D000818:Animals; D005260:Female; D019417:Hindlimb Suspension / Q000009:adverse effects; D051379:Mice; D008810:Mice, Inbred C57BL; D023421:Models, Animal; D009133:Muscular Atrophy / Q000209:etiology / Q000503:physiopathology*