A multicellular systems biology model predicts epidermal morphology, kinetics and Ca2+ flow.
BACKGROUND
Systems biology is currently focused on integrating intracellular networks, although clinically, diseases are largely defined by their histological features. For example, no computational model can simulate today the formation of a horizontally layered epidermis. Since the epidermis is the most complex structured epithelial tissue, systems biology models could yield important insights in epithelial tissue, in which most of all human cancers arise.


RESULTS
We describe the algorithms of a system, capable of simulating the tissue homeostasis in human epidermis leading to a horizontally layered tissue with cells of different differentiation stages. The system predicts epidermal morphology, tissue kinetics and 2D flow of Ca2+ ions. Predicted properties of an epidermis with a healthy and a disturbed barrier are compared with the literature. The system closely mimics the respecting physiological situations.


BACKGROUND
Additional information and films of the simulation are available at the website. Source code is available on request. http://www.zbh.uni-hamburg.de/research/ESB/index.php


BACKGROUND
grabe@zbh.uni-hamburg.de
Grabe
Niels
N
Center for Bioinformatics, University Hamburg, Bundesstrasse 43, 20146 Hamburg, Germany. grabe@zbh.uni-hamburg.de
Neuber
Karsten
K
D000465:Algorithms; D002118:Calcium / Q000378:metabolism*; D002454:Cell Differentiation; D049109:Cell Proliferation; D002478:Cells, Cultured; D003198:Computer Simulation; D000078404:Epidermal Cells; D004817:Epidermis / Q000502:physiology*; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D049490:Systems Biology / Q000379:methods
D002118:Calcium