Studies on the drug release properties of nano-encapsulated indomethacin microparticles.
Indomethacin micro-crystals sized approximately 2 microm have been encapsulated with polyelectrolyte multi-layers for the purpose of controlled release. Charged linear poly (dimethyldiallyl ammonium chloride) (PDDA) and poly (styrene sulphonate) (PSS) were alternatively deposited on approximately 2 microm drug micro-crystals. The release of indomethacin from coated micro-crystals was measured in aqueous solutions of pH 1.4 and 6.8. The polyelectrolyte multi-layer capsule thickness was proved to control. The results provided a method of achieving prolonged drug release through self-assembly of polymeric shells on drug microcrystals.
Chen
Y
Y
Zheijiang University, Hangzhou, Zhejiang, PR China. yfchen@dial.zju.edu.cn
Lin
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X
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations / Q000493:pharmacokinetics; D004339:Drug Compounding / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D007213:Indomethacin / Q000493:pharmacokinetics; D008854:Microscopy, Electron / Q000379:methods; D049329:Nanostructures; D011095:Polyethylenes; D011137:Polystyrenes; D000644:Quaternary Ammonium Compounds
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D011095:Polyethylenes; D011137:Polystyrenes; D000644:Quaternary Ammonium Compounds; C041004:poly-N,N-dimethyl-N,N-diallylammonium chloride; C003321:polystyrene sulfonic acid; D007213:Indomethacin