Strategies for the NMR-based identification and optimization of allosteric protein kinase inhibitors.
Jahnke
Wolfgang
W
Novartis Institutes for Biomedical Research, Discovery Technologies, WSJ-88.904, 4002 Basel, Switzerland. wolfgang.jahnke@novartis.com
Blommers
Marcel J J
MJ
Fernández
César
C
Zwingelstein
Christian
C
Amstutz
René
R
D000225:Adenine / Q000031:analogs & derivatives; D000255:Adenosine Triphosphate / Q000737:chemistry / Q000378:metabolism; D000494:Allosteric Regulation / Q000187:drug effects; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D047428:Protein Kinase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D011494:Protein Kinases / Q000737:chemistry* / Q000378:metabolism*; D017434:Protein Structure, Tertiary
D008024:Ligands; D047428:Protein Kinase Inhibitors; D000255:Adenosine Triphosphate; D011494:Protein Kinases; D000225:Adenine