Microgemma vivaresi (Microsporidia: Tetramicridae): host reaction to xenomas induced in sea scorpions, Taurulus bubalis (Osteichthyes: Cottidae).
Xenomas caused by Microgemma vivaresi Canning, Feist, Longshaw, Okamura, Anderson, Tsuey Tse et Curry, 2005 were found in liver and skeletal muscle of sea scorpions, Taurulus bubalis (Euphrasen). All muscle xenomas examined were in an advanced stage of destruction. In developing xenomas found in liver, parasites were restricted to the centre of the cell, separated from a parasite-free zone by a nuclear network formed by branching of the host cell nucleus. Although xenomas were able to reach a size of several hundred microns, the surface remained a simple plasma membrane. Host reactions took the form of penetration by phagocytes and isolation by fibroblasts. Once the xenoma had been attacked, the nuclear profiles became pycnotic and the barrier between parasitized and parasite-free zones was lost. Parasite antigens cannot be exposed at the surface of intact xenomas, as the host does not recognise the enlarging cell as foreign. Breaches in the plasma membrane of the xenoma and leakage of parasite antigens are thought to be the stimuli for phagocyte entry into the cell, its isolation by fibroblasts and eventual granuloma formation.
Canning
Elizabeth U
EU
Department of Biological Sciences, Imperial College London, Silwood Park Campus, Ascot, Berkshire SL5 7PY, UK. e.canning@ic.ac.uk
Curry
Alan
A
D000818:Animals; D016817:Apansporoblastina / Q000254:growth & development* / Q000648:ultrastructure; D004739:England; D005347:Fibroblasts / Q000382:microbiology; D005393:Fish Diseases / Q000276:immunology / Q000382:microbiology* / Q000473:pathology*; D005399:Fishes; D015726:Giant Cells / Q000382:microbiology*; D006790:Host-Parasite Interactions; D008018:Life Cycle Stages / Q000502:physiology*; D008099:Liver / Q000382:microbiology; D008854:Microscopy, Electron; D016881:Microsporidiosis / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D018482:Muscle, Skeletal / Q000382:microbiology; D010587:Phagocytosis / Q000276:immunology