title: Incidence of tuberculosis in mountain areas and surrounding townships: dose-response relationship by geographic analysis.
abstract: OBJECTIVE
  The incidence of tuberculosis (TB) in Taiwan is known to be high in aboriginal mountain areas and low in the surrounding non-mountain areas. The aim of this study was to assess whether TB incident cases in the surroundings of mountain areas decreased with distance from foci of mountain areas.
  
  
  METHODS
  The mountain areas in Taiwan are adjacent to each other and divided into four geographic groups. Townships with high TB incidence in each group were treated as the foci of TB infection. The surrounding townships were then classified, by distance away from foci, into three levels: < 20 km, 20 to 40 km, and 40 to 60 km. Data were obtained on a total of 84,366 TB cases from 1991 to 1997 from the Taiwan Tuberculous Disease Registry Center.
  
  
  RESULTS
  The incidence of TB in each of the four groups was significantly higher in the mountain areas compared with non-mountain areas, with relative risks ranging from 8.4 (95% confidence interval [CI], 7.8-9.1) for the southern group to 15.0 (95% CI, 13.4-16.9) for the northern group. Relative risks for surrounding townships decreased with distance in all four groups. Such a gradient relationship was statistically significant.
  
  
  CONCLUSIONS
  A significant dose-response relationship between distance from townships with a high incidence of TB and the incidence of TB in the surrounding areas has been demonstrated.
authors: Taichung County Health Bureau, Taichung County, Taiwan.
authors: Yen-Po
authors: YP
authors: Yeh
authors: Hong-Jen
authors: HJ
authors: Chang
authors: Jian
authors: J
authors: Yang
authors: Shu-Hui
authors: SH
authors: Chang
authors: Jen
authors: J
authors: Suo
authors: Tony Hsiu-Hsi
authors: TH
authors: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D005843:Geography; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D016012:Poisson Distribution; D044382:Population Groups / Q000706:statistics & numerical data; D012306:Risk; D018570:Risk Assessment; D012307:Risk Factors; D012423:Rural Health / Q000706:statistics & numerical data*; D012424:Rural Population / Q000706:statistics & numerical data*; D012944:Social Support; D013624:Taiwan / Q000453:epidemiology; D014376:Tuberculosis / Q000453:epidemiology* / Q000208:ethnology / Q000635:transmission