[Isoprostanes, biomarkers of lipid peroxidation in humans. Part 3: Biomarkers and mediators in vascular physiology and disease].
The 15-series F(2)-isoprostanes mediate vasoconstriction in different vascular beds and species. This contraction is mediated by the thromboxane receptors stimulation, and may be modulated by the endothelium. Furthermore, 15-F(2t)-IsoP induces smooth muscle cells mitogenesis and monocyte adhesion to endothelial cells. Some 15-series E(2)-isoprostanes are more potent than F(2)-isoprostanes. In clinical studies, 15-F(2t)-IsoP levels are increased in vascular disorders involving atherosclerosis, ischemia-reperfusion and inflammation. F(2)-isoprostane levels correlate to the severity of heart failure and pulmonary hypertension, raising the potential prognostic interest of these biomarkers. Whether the effects observed in vitro are observed consistently in vivo at physiological concentrations and whether these effects contribute to pathological states in vivo is still debated.
Cracowski
J-L
JL
Laboratoire de pharmacologie, HP2, EA3745, faculté de médecine de Grenoble, domaine de la Merci, 38700 La Tronche, Grenoble, France. jean-luc.cracowski@ujf-grenoble.fr
Berdeaux
O
O
Durand
T
T
D015415:Biomarkers / Q000032:analysis*; D001808:Blood Vessels / Q000503:physiopathology*; D015237:Dinoprost / Q000031:analogs & derivatives / Q000032:analysis / Q000502:physiology; D006801:Humans; D028421:Isoprostanes / Q000032:analysis* / Q000502:physiology*; D015227:Lipid Peroxidation; D014652:Vascular Diseases / Q000503:physiopathology*; D014661:Vasoconstriction
D015415:Biomarkers; D028421:Isoprostanes; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost