Malignant thymoma associated with mixed connective tissue disease: a case report.
Many autoimmune diseases have been reported to be associated with malignancy. Mixed connective tissue disease (MCTD), however, has rarely been associated with malignancy. Thymoma is one of the neoplasms often reported to be related to various immunological disorders. Among the types of thymoma defined by WHO, malignant thymoma (thymoma type C) is the one least reported to be associated with autoimmune disease. Here, we report a case of malignant thymoma with concurrent MCTD, which manifested with acrosclerosis, Raynaud's phenomenon, arthritis (synovitis), and a high titer of anti-ribonucleoprotein antibody.
Lin
Yu-Chih
YC
Department of Internal Medicine, Rheumatology Unit, Kaohsiung Medical University Hospital, Kaohsiung City 807, Taiwan, ROC.
Wu
Chen-Ching
CC
Ou
Tsan-Teng
TT
Yen
Jeng-Hsien
JH
Liu
Hong-Wen
HW
Tsai
Wen-Chan
WC
D005260:Female; D006801:Humans; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000150:complications*; D013945:Thymoma / Q000150:complications*; D013953:Thymus Neoplasms / Q000150:complications*