Generation of reactive oxygen species by a persulfide (BnSSH).
Hydropersulfides (RS(x)SH) have been implicated as important intermediates in the cell-killing action of the anticancer natural products leinamycin and varacin. It has been suggested that persulfides can mediate the conversion of molecular oxygen to reactive oxygen species (O2*-, H2O2, and HO*). Here, experiments with synthetic benzyl hydrodisulfide (BnSSH) provide direct evidence that persulfides readily decompose to produce reactive oxygen species under physiologically relevant conditions.
Chatterji
Tonika
T
Department of Chemistry, University of Missouri-Columbia, Columbia, MO 65211, USA.
Keerthi
Kripa
K
Gates
Kent S
KS
D000970:Antineoplastic Agents / Q000494:pharmacology; D016923:Cell Death; D004220:Disulfides / Q000737:chemistry / Q000378:metabolism; D008954:Models, Biological; D017382:Reactive Oxygen Species / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship; D013440:Sulfides / Q000737:chemistry* / Q000378:metabolism
D000970:Antineoplastic Agents; D004220:Disulfides; D017382:Reactive Oxygen Species; D013440:Sulfides; C051552:persulfides; C034956:benzyl hydrodisulfide