Direct receptor cross-talk can mediate the modulation of excitatory and inhibitory neurotransmission by dopamine.
Dopamine is a neurotransmitter that can regulate both excitatory and inhibitory fast synaptic transmission. The overlapping dopaminergic, glutamatergic, and GABAergic systems provide a basis for the interaction between these three neurotransmitters. Although there is considerable evidence for the involvement of second-messenger systems to mediate receptor cross-talk between these receptor systems, there is emerging evidence that receptors can interact through direct protein-protein interactions. The functional implications and overall significance of the dopamine/glutamate/GABA interactions will be examined.
Lee
Frank J S
FJ
Department of Neuroscience, Centre for Addiction and Mental Health, Clarke Division, University of British Columbia, Vancouver, British Columbia, V6T 2B5 Canada.
Wang
Yu-tian
YT
Liu
Fang
F
D000818:Animals; D004298:Dopamine / Q000494:pharmacology* / Q000502:physiology; D018698:Glutamic Acid / Q000502:physiology; D006801:Humans; D018377:Neurotransmitter Agents; D020239:Receptor Cross-Talk / Q000502:physiology*; D011954:Receptors, Dopamine / Q000502:physiology; D018079:Receptors, GABA / Q000502:physiology; D017470:Receptors, Glutamate / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D018377:Neurotransmitter Agents; D011954:Receptors, Dopamine; D018079:Receptors, GABA; D017470:Receptors, Glutamate; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D004298:Dopamine