title: Animal fat consumption and pancreatic cancer incidence: evidence of interaction with cigarette smoking.
abstract: OBJECTIVE
  A large difference in fat intake and pancreatic cancer incidence exists among populations worldwide. This study investigated the relation between fat consumption and pancreatic cancer risk at the population level.
  
  
  METHODS
  Fat consumption data for nine periods (1964-1994) and age-standardized pancreatic cancer incidence data for five periods (1973-1997) in 35 countries were derived from the Food and Agriculture Organization and World Health Organization, respectively.
  
  
  RESULTS
  A significant positive correlation was found between animal fat consumption and pancreatic cancer incidence in all periods examined (r=0.40-0.74, p=0.021 to < 0.0001 in men and r=0.50-0.66, p=0.01 to 0.0001 in women). After adjustment for smoking and other confounders, animal fat consumption in all nine periods considered was still significantly and positively associated with pancreatic cancer incidence in the 1993 to 1997 period in both sexes. The stratified analysis showed that this association was significant only in countries with below median level of smoking (< 2273 cigarettes/adult/year). A similar but less pronounced effect was observed for total fat consumption.
  
  
  CONCLUSIONS
  The consumption of fat, especially animal fat, was associated with an increased risk of pancreatic cancer and this association was modified by levels of cigarette smoking.
authors: Cancer Prevention Institute, Dayton, OH, USA. Zhangjianjun@uams.edu
authors: Jianjun
authors: J
authors: Zhang
authors: Zijin
authors: Z
authors: Zhao
authors: Hans J
authors: HJ
authors: Berkel
mesh_terms: D000818:Animals; D004041:Dietary Fats / Q000009:adverse effects* / Q000145:classification / Q000378:metabolism; D005260:Female; D014943:Global Health; D006801:Humans; D015994:Incidence; D008297:Male; D008461:Meat Products / Q000009:adverse effects; D010190:Pancreatic Neoplasms / Q000453:epidemiology* / Q000209:etiology; D018570:Risk Assessment; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology
chemical_list: D004041:Dietary Fats