Age-related changes in haematology and serum chemistry of Weiser-Maples guineapigs (Cavia porcellus).
Age-related changes in haematology and serum chemistry values were examined in male and female Weiser-Maples guineapigs (Cavia porcellus). Haematological changes that significantly (P<0.01) correlated with ageing were increased white blood cell and neutrophil counts in both sexes, decreased lymphocyte counts in both sexes, decreased reticulocyte and platelet counts in males, and decreased basophil counts in females. For serum chemistry, increases in total protein, triglycerides, blood urea nitrogen and creatinine were seen in both sexes, along with increases in total cholesterol in males and sodium in females. Decreased alkaline phosphatase in both sexes and decreased chloride in males were significantly (P<0.01) associated with age. These age-related changes are compared with the published literature.
Kitagaki
M
M
Shiseido Research Center, Kanazawa, Yokohama, Kanagawa, Japan. masato.kitagaki@to.shiseido.co.jp
Yamaguchi
M
M
Nakamura
M
M
Sakurada
K
K
Suwa
T
T
Sasa
H
H
D000367:Age Factors; D000375:Aging / Q000097:blood*; D000818:Animals; D001491:Basophils / Q000378:metabolism; D001774:Blood Chemical Analysis; D001792:Blood Platelets / Q000378:metabolism; D005260:Female; D006168:Guinea Pigs / Q000097:blood*; D007958:Leukocyte Count; D008297:Male; D008962:Models, Theoretical; D009504:Neutrophils / Q000378:metabolism; D012044:Regression Analysis; D012156:Reticulocytes / Q000378:metabolism; D012737:Sex Factors