title: Effect of gonadotropin-releasing-hormone-induced hypogonadism on insulin action as assessed by euglycemic clamp studies in men.
abstract: OBJECTIVE
  In view of the relationship between hyperandrogenism and impaired insulin action in women with polycystic ovarian syndrome, we sought to investigate the effects of decreasing androgen levels on insulin action in men.
  
  
  METHODS
  Prospective clinical study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Ten normal healthy men.
  
  
  METHODS
  GnRH agonist, 3.75 mg monthly for 3 months.
  
  
  METHODS
  Rate of glucose uptake, serum insulin, and glucose levels.
  
  
  RESULTS
  GnRH treatment caused a significant fall in circulating testosterone levels, from 572 +/- 58 ng/dL to 178 +/- 66 ng/dL (P<.05). However, as assessed by euglycemic hyperinsulinemic clamp studies, there was no significant change in glucose uptake.
  
  
  CONCLUSIONS
  In normal men, administration of a GnRH analogue was associated with a decrease in testosterone levels but not in insulin action.
authors: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, West Virginia University-Charleston Division, Charleston, West Virginia, USA.
authors: Subodhsingh
authors: S
authors: Chauhan
authors: Michael P
authors: MP
authors: Diamond
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015309:Glucose Clamp Technique / Q000379:methods*; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D007006:Hypogonadism / Q000097:blood* / Q000139:chemically induced*; D007328:Insulin / Q000097:blood*; D008297:Male; D011446:Prospective Studies
chemical_list: D001786:Blood Glucose; D007328:Insulin; D007987:Gonadotropin-Releasing Hormone