Ultrastructural and biosynthetic changes in epitheliocytes of renal tubules during the development of chronic renal failure.
Structural and functional studies of changes in the tubular compartment during progressive renal dysfunction showed that the major types of damage to tubular cells include dystrophy, degeneration, and atrophy. These changes were associated with inhibition of biosynthetic processes in the tubular epithelium, progressive interstitial fibrosis, and disturbances in the structure and function of peritubular microvessels.
Nepomnyashchikh
L M
LM
Department of General Pathology and Pathophysiology, Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. pathol@soramn.ru
Tov
N L
NL
Aidagulova
S V
SV
Nesterov
D V
DV
D000293:Adolescent; D000328:Adult; D000368:Aged; D001345:Autoradiography; D004847:Epithelial Cells / Q000378:metabolism* / Q000648:ultrastructure*; D005260:Female; D005921:Glomerulonephritis / Q000473:pathology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology* / Q000473:pathology; D007684:Kidney Tubules / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000473:pathology