title: Aromatic benzotriazole amides--synthesis and biological evaluation.
abstract: Four derivatives of benzotriazole-5-carboxylic acid were synthesized as potential UV-light dependent DNA cleaving agent. The effect of these compounds on phiX174 RF1 phage DNA and pBR322 plasmid DNA was investigated with and without UV exposure. It has been found that the two compounds exert the influence on topological forms of DNA.
authors: Department of Organic Chemistry, Medical University of Białystok, 2A, A. Mickiewicza Str, 15-222 Białystok, Poland. pucanka@amb.edu.pl
authors: Anna
authors: A
authors: Pućkowska
authors: Danuta
authors: D
authors: Bartulewicz
authors: Krystyna
authors: K
authors: Midura-Nowaczek
mesh_terms: D010584:Bacteriophage phi X 174 / Q000737:chemistry; D004247:DNA / Q000737:chemistry / Q000187:drug effects* / Q000528:radiation effects; D010957:Plasmids / Q000737:chemistry; D011838:Radiation-Sensitizing Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D014466:Ultraviolet Rays
chemical_list: D011838:Radiation-Sensitizing Agents; D014230:Triazoles; C012771:benzotriazole; D004247:DNA