[Cardiac manifestations of laminopathies].
Dilated cardiomyopathy (DCM) of genetic origin represents about 25% of all so-called primary DCM. Cases due to mutation of the gene which codes the lamins A and C (LMNA) carry a poor prognosis with a high risk of sudden death. The finding of primary DCM in a young person associated with conduction defects or arrhythmias should lead to investigation for mutation of the gene of lamins A and C, even in the absence of a suggestive family history. The authors report 5 cases of DCM, with and without associated skeletal muscular disease, due to laminopathies.
Brette
S
S
Service de cardiologie U350, centre hospitalier universitaire, Angers.
Penisson-Besnier
I
I
Dupuis
J M
JM
Bonne
G
G
Victor
J
J
D000293:Adolescent; D000328:Adult; D002311:Cardiomyopathy, Dilated / Q000150:complications* / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D034904:Lamin Type A / Q000235:genetics*; D008297:Male; D009140:Musculoskeletal Diseases / Q000209:etiology; D009154:Mutation; D011379:Prognosis
D034904:Lamin Type A; C440308:lamin C