title: Counts of stromal precursor cells in heterotopic splenic transplants in CBA mice of different age.
abstract: The content of stromal precursor cells in heterotopic splenic transplants from old and young mice changed appreciably after cross transplantation to old and young animals. The content of CFC-F in the young-->old transplants decreased almost 1.5 times in comparison with the young-->young transplants, the counts of CFC-F in old-->old transplants were minimum in comparison with all other groups (2.5+/-0.1), while in the old-->young group transplants this value increased almost 8-fold (to 19.0+/-1.3) and surpassed the control level. Age-associated shifts in the splenic stromal tissue were determined by regulatory influences of the host, rather than by decreased count of stromal precursor cells in the tissue.
authors: Laboratory of Immunity Regulation, N. F. Gamaleya Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow.
authors: Yu F
authors: YF
authors: Gorskaya
authors: V G
authors: VG
authors: Nesterenko
mesh_terms: D000367:Age Factors; D000818:Animals; D002452:Cell Count; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000166:cytology / Q000637:transplantation*; D013234:Stem Cells / Q000166:cytology*; D017154:Stromal Cells / Q000166:cytology