O-Methylglucogalloyl esters: synthesis and evaluation of their antimycotic activity.
The two anomers of O-methyl gluco-2,3-digalloyl esters were synthesized and their antimycotic activity toward yeasts of biomedical importance was evaluated. When used at subinhibitory concentration and regardless of stereochemistry at the anomeric carbon, these compounds enhance the antimycotic activity of Amphotericin B.
Romani
Annalisa
A
Dipartimento di Scienze Farmaceutiche, Polo Scientifico Università di Firenze, Via U. Schiff, 6, I-50019 Sesto Fiorentino (FI), Italy.
Menichetti
Stefano
S
Arapitsas
Panagiotis
P
Nativi
Cristina
C
Turchetti
Benedetta
B
Buzzini
Pietro
P
D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D041221:Candida glabrata / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure; D013237:Stereoisomerism
D000935:Antifungal Agents; D004952:Esters; D005707:Gallic Acid; D000666:Amphotericin B