A likelihood approach for quantitative-trait-locus mapping with selected pedigrees.
Selective sampling is a cost-effective design for mapping quantitative trait loci (QTLs). A unified framework, which naturally combines two complementary sources of linkage information in the data, is proposed for the mapping of QTLs using selected pedigrees. Score statistics for detecting linkage are introduced for single-locus models (univariate or bivariate phenotypes) and two-locus epistasis models. A computer implementation of the methods for single-locus univariate-phenotype models is provided for nuclear families with arbitrary number of sibs and is freely available.
Wang
K
K
Program in Public Health Genetics, University of Iowa, Iowa City, Iowa 52242, USA. kai-wang@uiowa.edu
D000465:Algorithms; D002874:Chromosome Mapping / Q000379:methods*; D003627:Data Interpretation, Statistical; D004843:Epistasis, Genetic; D008040:Genetic Linkage; D005819:Genetic Markers; D005822:Genetic Vectors; D006801:Humans; D016013:Likelihood Functions; D015810:Linkage Disequilibrium; D008126:Lod Score; D008957:Models, Genetic; D015233:Models, Statistical; D010375:Pedigree; D010641:Phenotype; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable
D005819:Genetic Markers