title: Relationship of extent and nature of dysfunctional myocardium to brain natriuretic peptide in patients with ischemic left ventricular dysfunction.
abstract: We studied the relationship between brain natriuretic peptide (BNP) levels and viable myocardium and ischemic myocardium, regional scar and regional contractile function. Fifty-nine patients underwent dobutamine echocardiography and magnetic resonance imaging and resting BNP levels were determined. By magnetic resonance imaging, total extent of dysfunctional myocardium correlated strongest with BNP (r = 0.60, p < 0.0001). The extent of scar, viability and ischemia also correlated. At dobutamine echocardiography, a composite of dysfunctional and ischemic myocardium was the strongest correlate of BNP (r = 0.48, p < 0.0001), with less strong correlations by global parameters. The extent of dysfunctional myocardium, rather than its nature determines BNP levels.
authors: Department of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia.
authors: Charles A
authors: CA
authors: Nelson
authors: Colin
authors: C
authors: Case
authors: Jane
authors: J
authors: McCrohon
authors: Thomas H
authors: TH
authors: Marwick
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002306:Cardiac Volume; D003404:Creatinine / Q000097:blood; D025401:Echocardiography, Stress; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009200:Myocardial Contraction; D017202:Myocardial Ischemia / Q000097:blood* / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000473:pathology
chemical_list: D020097:Natriuretic Peptide, Brain; D003404:Creatinine