[Effect of growth hormone on non-protein respiratory quotient and oxidation rate of protein after burn injury].
OBJECTIVE
To investigate the changes in non-protein respiratory quotient (NPRQ) and oxidation rate of protein after burn injury, and the effect of growth hormone (GH) administration on metabolism.


METHODS
Sixteen male minipigs were subjected to 35% total body surface area (TBSA) full thickness burn, and the burned minipigs were randomly divided into two groups: GH group and control group. NPRQ and oxidation rate of protein were monitored by means of the metabolic cart.


RESULTS
After burns the oxygenation rate of protein increased slowly, with NPRQ reduced significantly. The extent of reduction was higher in GH group compared to the control group, but there was no significant difference in oxidation rate between the two groups.


CONCLUSIONS
The results suggest that administration of GH could enhance lipid catabolism, with no obvious effect on protein catabolism. However, hyperglycemia is apt to occur.
Hao
Dai-feng
DF
Burns Institute, 304th Hospital Affiliated to General Hospital of PLA, Beijing 100037, China.
Guo
Zhen-rong
ZR
Chai
Jia-ke
JK
D000818:Animals; D002056:Burns / Q000378:metabolism*; D004195:Disease Models, Animal; D004734:Energy Metabolism / Q000187:drug effects; D013006:Growth Hormone / Q000494:pharmacology*; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D011506:Proteins / Q000378:metabolism*; D011897:Random Allocation; D013552:Swine; D013556:Swine, Miniature
D011506:Proteins; D013006:Growth Hormone