title: Characterization of lacrimal gland lesions and possible pathogenic mechanisms of keratoconjunctivitis sicca in dogs with leishmaniosis.
abstract: In a previous study, it was found that 2.8% of dogs with leishmaniosis had keratoconjunctivitis sicca (KCS). The aim of this study was to characterize the lesions present in the lacrimal glands of dogs with leishmaniosis and to determine the presence of the parasite by means of immunohistochemistry. The inflammatory infiltrate was described as granulomatous or pyogranulomatous and was located around the ductal component of the glands. Immunoperoxidase staining localized the parasites following the same pattern. Samples from eyes that had clinical signs compatible with KCS presented inflammatory infiltrate and parasite more commonly than those from eyes without clinical signs. One of the mechanisms of KCS in dogs with leishmaniosis may be the inflammatory infiltrate located around the ducts of lacrimal glands, producing retrograde accumulation and retention of secretion. Meibomian gland was the most commonly affected by the infiltrate, highlighting the possibility of a qualitative KCS in these dogs.
authors: Departarnent de Medicina i Cirurgia Animals, Facultat de Veterinària, Edifici V, Campus UAB, 08193 Bellaterra, Cerdanyola del Vallès, Barcelona, Spain. Carolina.Naranjo@uab.es
authors: Carolina
authors: C
authors: Naranjo
authors: Dolors
authors: D
authors: Fondevila
authors: Marta
authors: M
authors: Leiva
authors: Xavier
authors: X
authors: Roura
authors: Teresa
authors: T
authors: Peña
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000469:parasitology* / Q000473:pathology; D004285:Dogs; D007150:Immunohistochemistry / Q000662:veterinary; D007638:Keratoconjunctivitis Sicca / Q000150:complications / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D007765:Lacrimal Apparatus / Q000469:parasitology* / Q000473:pathology; D018314:Leishmania infantum / Q000254:growth & development*; D007896:Leishmaniasis / Q000150:complications / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D008537:Meibomian Glands / Q000469:parasitology / Q000473:pathology