The role of cannabinoid system on immune modulation: therapeutic implications on CNS inflammation.
There is a growing amount of evidence suggesting that cannabinoids may be neuroprotective in CNS inflammatory conditions. Advances in the understanding of the physiology and pharmacology of the cannabinoid system have increased the interest of cannabinoids as potential therapeutic targets. Cannabinoid receptors and their endogenous ligands, the endocannabinoids, have been detected in cells of the immune system, as well as in brain glial cells. In the present review it is summarized the effects of cannabinoids on immune reactivity and on the regulation of neuroinflammatory processes associated with brain disorders with special attention to chronic inflammatory demyelinating diseases such as multiple sclerosis.
Correa
Fernando
F
Neural Plasticity Unit, Neuroimmunology Group, Instituto Cajal, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
Mestre
Leyre
L
Molina-Holgado
Eduardo
E
Arévalo-Martín
Angel
A
Docagne
Fabian
F
Romero
Eva
E
Molina-Holgado
Francisco
F
Borrell
José
J
Guaza
Carmen
C
D001921:Brain / Q000002:abnormalities / Q000473:pathology; D002186:Cannabinoids / Q000494:pharmacology / Q000627:therapeutic use*; D002493:Central Nervous System Diseases / Q000145:classification / Q000188:drug therapy*; D003711:Demyelinating Diseases / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007107:Immune System / Q000187:drug effects* / Q000378:metabolism; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000473:pathology; D009457:Neuroglia / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology; D043882:Receptors, Cannabinoid / Q000378:metabolism
D002186:Cannabinoids; D018696:Neuroprotective Agents; D043882:Receptors, Cannabinoid