C-terminal Pro-Gly-Pro tripeptide in contrast to full-length neuropeptide semax exhibits no neuroprotective effect in experimental cerebral ischemia.
The C-terminal fragment Pro-Gly-Pro of semax does not modulate the development of symptoms of neurological deficiency and mortality in rats with incomplete global cerebral ischemia. Hence, previously revealed neuroprotective effects of semax are mainly determined by corticotropin ACTH4-7 fragment.
Fadyukova
O E
OE
Faculty of Fundamental Medicine; Biological Faculty, M. V. Lomo-nosov Moscow State University, Russia. olevfa@fbm.msu.ru
Kadi
A
A
Bai
Ou
O
Andzhusheva
G M
GM
Koshelev
V B
VB
D000818:Animals; D002545:Brain Ischemia / Q000517:prevention & control*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology*; D011392:Proline / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats
D018696:Neuroprotective Agents; D009842:Oligopeptides; C113164:prolyl-glycyl-proline; D011392:Proline