title: Hormone-sensitive lipase as mediator of lipolysis in contracting skeletal muscle.
abstract: The authors propose that the enzyme hormone-sensitive lipase (HSL), which is the rate-limiting enzyme for hydrolysis of triacylglycerol in adipocytes, also regulates the intramyocellular triacylglycerol mobilization and is controlled by mechanisms similar to those regulating glycogen phosphorylase. From an exercise perspective, it is fascinating that the primary enzymatic setting allows simultaneous mobilization of all major extramuscular and intramuscular energy stores.
authors: Copenhagen Muscle Research Centre at Department of Medical Physiology, The Panum Institute, University of Copenhagen, Copenhagen, Denmark. mdonsmark@mfi.ku.dk
authors: Morten
authors: M
authors: Donsmark
authors: Jozef
authors: J
authors: Langfort
authors: Cecilia
authors: C
authors: Holm
authors: Thorkil
authors: T
authors: Ploug
authors: Henrik
authors: H
authors: Galbo
mesh_terms: D000818:Animals; D004837:Epinephrine / Q000378:metabolism; D015444:Exercise / Q000502:physiology; D006801:Humans; D008066:Lipolysis / Q000502:physiology*; D009119:Muscle Contraction / Q000502:physiology*; D018482:Muscle, Skeletal / Q000378:metabolism*; D010805:Physical Conditioning, Animal / Q000502:physiology; D051381:Rats; D002787:Sterol Esterase / Q000378:metabolism*
chemical_list: D002787:Sterol Esterase; D004837:Epinephrine