title: Chlorination of 3beta-hydroxyl-5-Delta steroids with anhydrous ferric chloride.
abstract: Treatment of 3beta-hydroxyl-5-Delta steroids with anhydrous FeCl(3) in CH(2)Cl(2) afforded reasonable yields of the corresponding alkyl chlorides with a retention of configurations. The structures of the chlorine-exchanging products were determined by NMR and HRMS spectra. The absolute configurations were confirmed by X-ray crystal analysis of 3beta-chloro-androst-5-en-17-one. The generality and scope of the reaction were also investigated.
authors: Department of Chemistry, Zhengzhou University, 75 Da Xue Bei Lu, Zhengzhou 450052, PR China.
authors: Feng-Wu
authors: FW
authors: Liu
authors: Hong-Min
authors: HM
authors: Liu
authors: Yan-Bing
authors: YB
authors: Zhang
authors: Jing-Yu
authors: JY
authors: Zhang
authors: Li-Huan
authors: LH
authors: Tian
mesh_terms: D002712:Chlorides; D005290:Ferric Compounds / Q000737:chemistry*; D006914:Hydroxysteroids / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D015394:Molecular Structure
chemical_list: D002712:Chlorides; D005290:Ferric Compounds; D006914:Hydroxysteroids; C024555:ferric chloride