title: A case of ovarian hyperstimulation syndrome associated with the methylenetetrahydrofolate reductase mutation gene.
abstract: OBJECTIVE
  To report a case of ovarian hyperstimulation syndrome with methylenetetrahydrofolate reductase (MTHFR) gene 677T homozygosis mutation and A1298C gene heterozygosis mutation.
  
  
  METHODS
  Case report.
  
  
  METHODS
  A pregnant woman in an academic hospital.
  
  
  METHODS
  A woman with ovarian hyperstimulation syndrome.
  
  
  METHODS
  Nadroparin was administered for 2 weeks at a dosage of 200 IU/kg twice per day and then once per day; also administered once per day were folates, 5 mg; B6 vitamin, 15 mg; and B12 vitamin, 1 mg.
  
  
  METHODS
  Clinical follow-up.
  
  
  RESULTS
  Delivery was regular within the set time limits, and the fetus was born alive and in good health.
  
  
  CONCLUSIONS
  We believe that MTHFR mutation research could be executed in women before ovarian stimulation treatment, but other observations are necessary to support this recommendation.
authors: Division of Angiology, University Medical Hospital, Palermo, Italy. f_ferrara@virgilio.it
authors: Filippo
authors: F
authors: Ferrara
authors: Francesco
authors: F
authors: Meli
authors: Corrado
authors: C
authors: Amato
authors: Valentina
authors: V
authors: Cospite
authors: Francesco
authors: F
authors: Raimondi
authors: Salvatore
authors: S
authors: Novo
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D009154:Mutation; D016471:Ovarian Hyperstimulation Syndrome / Q000201:enzymology* / Q000235:genetics*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000201:enzymology* / Q000235:genetics*
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)