title: Three new sesquiterpene hemiacetals from Achillea vermicularis.
abstract: Three new sesquiterpene hemiacetals, tentatively named as achilleanone (1), vermiculone (2) and vermicularone (3) have been isolated from Achillea vermicularis, along with three other known compounds beta-amyrin, oleonolic acid and beta-sitosterol. The structure elucidation of new compounds was based primarily on two-dimensional (2D) NMR techniques including Nuclear Overhauser Effect/Enhancement (NOE), heteronuclear multiple quantum coherence (HMQC), heteronuclear multiple bond correlation (HMBC) and nuclear overhauser effect spectroscopy (NOESY) experiments. Compounds 1, 2 and 3 have displayed inhibitory potential against lipoxygenase enzyme in a concentration-dependent fashion with promising IC50 values.
authors: International Center of Science, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan. vuahmad@cyber.net.pk
authors: Viqar-Uddin
authors: VU
authors: Ahmad
authors: Umar
authors: U
authors: Farooq
authors: Javid
authors: J
authors: Hussain
authors: Farmanullah
authors: Muhammad Athar
authors: MA
authors: Abbasi
authors: Amir Reza
authors: AR
authors: Jassbi
authors: Sarfraz Ahmad
authors: SA
authors: Nawaz
authors: M Iqbal
authors: MI
authors: Choudhary
mesh_terms: D031162:Achillea / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D016859:Lipoxygenase Inhibitors; D012717:Sesquiterpenes