Dynamics and thermodynamics of dimerization of parallel G-quadruplexed DNA formed from d(TTAGn) (n=3-5).
Parallel G-quadruplexes formed from oligonucleotide sequences, d(TTAGn), where n = 3-5, have been shown to form a dimer through end-to-end stacking of 3'-terminal G-tetrads. The monomers and dimers of the G-quadruplexes are in dynamic equilibrium with an exchange rate of approximately 1 s-1. A thermodynamic study demonstrated that the dimerization of the G-quadruplexes is largely enthalpic in origin.
Kato
Yoshitake
Y
Department of Chemistry, University of Tsukuba, Tsukuba 305-8571, Japan.
Ohyama
Takako
T
Mita
Hajime
H
Yamamoto
Yasuhiko
Y
D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D019281:Dimerization; D054856:G-Quadruplexes; D006147:Guanine / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D013816:Thermodynamics
D006147:Guanine; D004247:DNA