Medullary thyroid cancer: the functions of raf-1 and human achaete-scute homologue-1.
Medullary thyroid cancer (MTC) is a prototypic neuroendocrine tumor of the thyroid C cells. Other than surgery, there are no curative therapies for MTC. In this review, we detail recent studies that suggest that targeting specific signaling pathways may be a viable strategy to control MTC tumor progression. Specifically, we discuss the role of the raf-1 and achaete-scute homologue-1 pathways in the MTC tumor growth and differentiation.
Chen
Herbert
H
Department of Surgery, University of Wisconsin Medical School, the University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin, USA. chen@surgery.wisc.edu
Kunnimalaiyaan
Muthusamy
M
Van Gompel
Jamie J
JJ
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism*; D018276:Carcinoma, Medullary / Q000201:enzymology*; D004789:Enzyme Activation; D006801:Humans; D020935:MAP Kinase Signaling System; D019908:Proto-Oncogene Proteins c-raf / Q000378:metabolism*; D012333:RNA, Messenger; D013964:Thyroid Neoplasms / Q000201:enzymology*
D051792:Basic Helix-Loop-Helix Proteins; D019908:Proto-Oncogene Proteins c-raf; D012333:RNA, Messenger; C065500:ASCL1 protein, human