title: Pathology and treatment of Eimeria zuernii coccidiosis in calves: investigations in an infection model.
abstract: Two studies were conducted in the Eimeria zuernii infection model in order to investigate the pathology of E. zuernii coccidiosis and the efficacy of toltrazuril (Baycox 5% suspension) in this infection. For this purpose, a total of 30 calves were infected experimentally with E. zuernii oocysts and faecal samples taken regularly from the rectum and examined for faecal consistency and oocyst excretion. Six of the calves underwent pathological examination at various points in time after infection. Significant macroscopic and microscopic changes were demonstrated and parasitic stages were identified in the intestinal mucosa of infected calves during the late prepatent and patent period. Inflammatory reactions revealed by light microscopy were confirmed by electron microscopical investigations. Treatment of calves with toltrazuril during the late prepatent period resulted in significantly lower frequencies of diarrhoea and levels of oocyst excretion, and weight gain was significantly higher than in shamtreated animals.
authors: Bayer HealthCare AG, Animal Health Division, 51368 Leverkusen, Germany.
authors: H-C
authors: HC
authors: Mundt
authors: B
authors: B
authors: Bangoura
authors: M
authors: M
authors: Rinke
authors: M
authors: M
authors: Rosenbruch
authors: A
authors: A
authors: Daugschies
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000469:parasitology / Q000503:physiopathology*; D003048:Coccidiosis / Q000188:drug therapy / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D003049:Coccidiostats / Q000008:administration & dosage / Q000627:therapeutic use*; D003967:Diarrhea / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary; D004539:Eimeria / Q000187:drug effects / Q000254:growth & development / Q000472:pathogenicity*; D005243:Feces / Q000469:parasitology; D033661:Oocysts / Q000472:pathogenicity; D016896:Treatment Outcome; D014227:Triazines / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D003049:Coccidiostats; D014227:Triazines; C036670:toltrazuril