Selection of candidate genes in hypertension.
Essential hypertension is a common disease with multifactorial etiology affecting up to 10 million individuals in the United Kingdom alone. Current knowledge of the genetic contribution to this trait is restricted to a number of rare variants that produce hypertensive phenotypes in a Mendelian fashion and to genes highlighted by work on blood pressure regulation in rodent models. Recent advances in comparative genomics, genome-wide scans for linkage, transcriptomics, proteomics, and metabolomics allow a systematic approach to the prioritization of candidate genes for hypertension and other complex traits. We review the current state of play in these fields related to hypertension and show, with a particular example, how these data may help target genetic studies in the future.
Mein
Charles A
CA
The Genome Centre and Clinical Pharmacology, The William Harvey Research Institute, Barts and The London, Charterhouse Square, London, UK.
Caulfield
Mark J
MJ
Munroe
Patricia B
PB
D000818:Animals; D030801:Animals, Genetically Modified; D001794:Blood Pressure; D002889:Chromosomes, Human, Pair 2; D004195:Disease Models, Animal; D008040:Genetic Linkage; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D010641:Phenotype; D040901:Proteomics; D051381:Rats