title: Melanocytic matricoma in a dog.
abstract: We report a tumor that developed at the root of the tail in a male, 2-year-old Shih Tzu dog. Histologically, the tumor consisted of basaloid epithelial cells, with shadow cells and neoplastic melanocyte proliferation. Immunohistochemically, epithelial components were positive for keratin/cytokeratin but basaloid cells were negative. Mononuclear or multinuclear melanocytes were positive for vimentin, S-100 protein, and HMB-45. In conclusion, this dog was diagnosed with canine melanocytic matricoma on the basis of the similarity of the histologic and immunohistochemical features in humans, and it may be the first case in an animal.
authors: Department of Veterinary Pathology, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-8510, Japan.
authors: S
authors: S
authors: Saito
authors: K
authors: K
authors: Suzuki
authors: H
authors: H
authors: Shibuya
authors: T
authors: T
authors: Yamaguchi
authors: T
authors: T
authors: Sato
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D006201:Hair Diseases / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D008544:Melanocytes / Q000473:pathology*; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins / Q000378:metabolism; D018296:Pilomatrixoma / Q000473:pathology / Q000662:veterinary*; D009418:S100 Proteins / Q000378:metabolism; D012878:Skin Neoplasms / Q000473:pathology / Q000662:veterinary*; D014746:Vimentin / Q000378:metabolism
chemical_list: D000951:Antigens, Neoplasm; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins; D009418:S100 Proteins; D014746:Vimentin