title: Amyloidosis associated with chronic lymphocytic leukemia.
abstract: Chronic lymphocytic leukemia (CLL), the most common form of leukemia in Western countries, rarely induces glomerular disease, but membranoproliferative glomerulonephritis or immunotactoid glomerulopathy has been reported. The proliferating cells in CLL are of mature B-cell origin and produce monoclonal immunoglobulin (Ig), thus leading to various kinds of autoimmune disorders or immunotactoid glomerulopathy. Although there have been a few reported cases of amyloidosis accompanying CLL, the type of amyloid fibrils has not been demonstrated nor described in detail, particularly regarding monoclonal Ig productivity. We report a rare case of amyloidosis associated with CLL, in which we detected ?-light chain type monoclonal Ig in the sera, urine, and on the surface membrane of lymphocytes, and discuss an association between monoclonal Ig-related disease and non-Hodgkin's lymphoma.
authors: Second Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
authors: Ryota
authors: R
authors: Ikee
authors: Shuzo
authors: S
authors: Kobayashi
authors: Noriaki
authors: N
authors: Hemmi
authors: Shigenobu
authors: S
authors: Suzuki
authors: Soichiro
authors: S
authors: Miura
mesh_terms: D000686:Amyloidosis / Q000150:complications* / Q000473:pathology; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged