Interventions during donor care before lung transplantation.
Improvement in the ratio of PaO2 to the fraction of inspired oxygen and treatment of pulmonary infections in donors have been cited as important goals for improving lungs before implantation and restoring marginal lungs to the donor pool. Likewise, improving donor PaO2 is often critical for other organs during donor care. The common physiological mechanisms responsible for hypoxemia are ventilation/perfusion mismatching, abnormal oxygen diffusion, and hypoventilation. These mechanisms are discussed and treatment options are considered.
Powner
David J
DJ
Vivian L. Smith Center for Neurologic Research, University of Texas Health Science Center at Houston, TX, USA.
Hewitt
Michael J
MJ
Levine
Robert L
RL
D001049:Apnea / Q000150:complications / Q000378:metabolism / Q000517:prevention & control; D001784:Blood Gas Analysis; D002423:Cause of Death; D046148:Donor Selection / Q000379:methods*; D006801:Humans; D000860:Hypoxia / Q000150:complications / Q000378:metabolism / Q000517:prevention & control; D017053:Infection Control; D016040:Lung Transplantation / Q000379:methods*; D009926:Organ Preservation / Q000379:methods; D010101:Oxygen Consumption; D011175:Positive-Pressure Respiration / Q000379:methods; D011300:Preoperative Care / Q000379:methods*; D011652:Pulmonary Circulation; D011653:Pulmonary Diffusing Capacity; D011654:Pulmonary Edema / Q000150:complications / Q000517:prevention & control; D020858:Tissue and Organ Harvesting / Q000379:methods; D009927:Tissue and Organ Procurement / Q000379:methods*; D014692:Ventilation-Perfusion Ratio