Catalytic chemoselective addition of acetonitrile to enolizable aldehydes with cationic Ru complex/DBU combination.
The cooperative catalysis of CpRu(PPh3)2(CH3CN)PF6 (1b) and DBU enables chemoselective nucleophilic activation of acetonitrile in the presence of base-sensitive aldehydes 2 to afford corresponding beta-hydroxynitriles in good yield.
Kumagai
Naoya
N
Graduate School of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Matsunaga
Shigeki
S
Shibasaki
Masakatsu
M
D000097:Acetonitriles / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D009570:Nitriles / Q000138:chemical synthesis; D009942:Organometallic Compounds; D012428:Ruthenium / Q000737:chemistry*; D014508:Urea / Q000031:analogs & derivatives / Q000737:chemistry
D000097:Acetonitriles; D000447:Aldehydes; D009570:Nitriles; D009942:Organometallic Compounds; D012428:Ruthenium; D014508:Urea; C483182:N,N'-dibutylurea