Urokinase increases the content and activity of matrix metalloproteinases 2 and 9 during in vivo constrictive arterial remodeling.
Perivascular application of urokinase to ballooned artery stimulating the formation of neointima and constrictive arterial remodeling increased the content and activity of matrix metalloproteinases 2 and 9 in vivo. Application of recombinant tissue plasminogen produced no such changes. It was demonstrated that urokinase stimulates expression of matrix metalloproteinases in vivo.
Solomatina
M A
MA
Russian Research-and-Production Center of Cardiology, Moscow. yeparfyon@cardio.ru
Plekhanova
O S
OS
Men'shikova
M Yu
MY
Ratner
E I
EI
Tkachuk
V A
VA
Parfenova
E V
EV
D000800:Angioplasty, Balloon / Q000009:adverse effects; D000818:Animals; D020212:Carotid Artery Injuries / Q000473:pathology / Q000503:physiopathology*; D016893:Carotid Stenosis / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D002452:Cell Count; D049109:Cell Proliferation; D003251:Constriction, Pathologic / Q000188:drug therapy; D004789:Enzyme Activation / Q000187:drug effects; D007150:Immunohistochemistry; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis / Q000378:metabolism*; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D017539:Tunica Intima / Q000187:drug effects / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology; D014568:Urokinase-Type Plasminogen Activator / Q000494:pharmacology*
D014568:Urokinase-Type Plasminogen Activator; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9