title: Efficiency for unretained solutes in packed column supercritical fluid chromatography. I. Theory for isothermal conditions and correction factors for carbon dioxide.
abstract: A general theory for efficiency of nonuniform columns with compressible mobile phase fluids is applied to the elution of an unretained solute in packed-column supercritical fluid chromatography (pSFC). The theoretical apparent plate height under isothermal conditions is given by the Knox equation multiplied by a compressibility correction factor f1, which is equal to the ratio of the temporal-to-spatial average densities of the mobile phase. If isothermal conditions are maintained, large pressure drops in pSFC should not result in excessive efficiency losses for elution of unretained solutes.
authors: Department of Chemistry, University of Minnesota Duluth, 10 University Drive, Duluth, MN 55812, USA. dpoe@d.umn.edu
authors: Donald P
authors: DP
authors: Poe
mesh_terms: D002853:Chromatography, Liquid / Q000295:instrumentation / Q000379:methods*; D008956:Models, Chemical