Distinct M50 and M100 auditory gating deficits in schizophrenia.
The time course of the schizophrenia auditory gating deficit may provide clues to mechanisms of impaired cognition. Magnetoencephalography was recorded during a standard paired-click paradigm. Using source strength of the M50 and M100 components for each click, calculated from dipole locations identified as underlying each component for the first click, a ratio of the second divided by the first was used to measure gating. Patients showed a left-hemisphere gating deficit in M50 and a bilateral gating deficit in M100. Hypothesizing that an early deficit may affect later processing, hierarchical regression was used to examine variance shared between the components. A left-hemisphere M100 gating deficit was coupled with the left M50 gating deficit. In contrast, a right-hemisphere M100 gating deficit was unrelated to M50 gating in either hemisphere. Investigations of interhemisphere gating relations may clarify group differences in regional connectivity and their role in gating.
Hanlon
Faith M
FM
Center for Functional Brain Imaging, New Mexico VA Health Care System, Albuquerque, New Mexico 87108, USA.
Miller
Gregory A
GA
Thoma
Robert J
RJ
Irwin
Jessica
J
Jones
Aaron
A
Moses
Sandra N
SN
Huang
Mingxiong
M
Weisend
Michael P
MP
Paulson
Kim M
KM
Edgar
J Christopher
JC
Adler
Lawrence E
LE
Cañive
Jose M
JM
D000328:Adult; D001307:Auditory Perception / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D015225:Magnetoencephalography; D008297:Male; D012565:Schizophrenic Psychology