A novel role for the LisRK two-component regulatory system in listerial osmotolerance.
Understanding how pathogenic bacteria sense and respond to environmental signals, including those involved in triggering virulence gene expression, is a fundamental biological goal. It is now known that the two-component regulatory system LisRK has a novel role in osmosensing and osmoregulation in the intracellular foodborne pathogen Listeria monocytogenes. Furthermore, htrA, a gene linked to osmotolerance and virulence potential in L. monocytogenes, is now known to be under the transcriptional control of LisRK.
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D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D018869:Heat-Shock Response; D006801:Humans; D008089:Listeria monocytogenes / Q000187:drug effects / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D009994:Osmolar Concentration; D015398:Signal Transduction; D012965:Sodium Chloride / Q000494:pharmacology; D014882:Water-Electrolyte Balance
D001426:Bacterial Proteins; D012965:Sodium Chloride