Inhalation toxicity of 1,3-propanediol in the rat.
1,3-Propanediol (504-63-2) was studied to determine the potential effects following repeated inhalation exposures to rats. Rats were exposed 6 hr/day, 5 days/wk for 2 wk (9 exposures) to vapor or vapor/aerosol mixtures of either 0, 41, 650, or 1800 mg 1,3-propanediol/m(3). In vivo responses were observed or measured daily. Clinical pathology and tissue pathology analyses were conducted after the 9th exposure and on half of each group following an 18-day recovery (nonexposure) period. All rats showed normal body weights. No unusual external signs of response were seen, and no deaths were encountered. Clinical pathology (blood counts, serum chemical parameters) and tissue pathology (gross pathology, organ weights, and histopathology) examinations in the 1,3-propanediol exposed rats were similar to those in the unexposed controls. The highest concentration tested, 1800 mg/m(3), which was the highest concentration that could practically be generated, was the no-observed-effect level (NOEL) for this study. 1,3-Propanediol does not appear to pose a significant hazard via inhalation of either the vapor or a vapor/aerosol mixture.
Scott
Robert S
RS
DuPont de Nemours and Company, Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA.
Frame
Steven R
SR
Ross
Paul E
PE
Loveless
Scott E
SE
Kennedy
Gerald L
GL
D000280:Administration, Inhalation; D000336:Aerosols; D000818:Animals; D001273:Atmosphere Exposure Chambers; D001772:Blood Cell Count; D001835:Body Weight / Q000187:drug effects; D008297:Male; D011409:Propylene Glycols / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
D000336:Aerosols; D011409:Propylene Glycols; C041787:1,3-propanediol