A relapsing inflammatory syndrome and active human herpesvirus 8 infection.
We describe an immunocompetent 61-year-old woman who was negative for human immunodeficiency virus and who had recurrent human herpesvirus 8 (HHV-8) infection associated with a relapsing systemic inflammatory syndrome characterized by fever, lymphadenopathy, splenomegaly, edema, arthrosynovitis, and rash. Kaposi's sarcoma developed 10 months after the initial clinical presentation. A correlation was documented between the recurrent clinical manifestations and the HHV-8 load in plasma and peripheral-blood mononuclear cells. Histologic examination of an enlarged lymph node heavily infected with HHV-8 revealed an atypical lymphoproliferative disorder characterized by paracortical hyperplasia and collapsed primary and secondary follicles.
Dagna
Lorenzo
L
Università Vita-Salute San Raffaele School of Medicine, Milan, Italy. lorenzo.dagna@hsr.it
Broccolo
Francesco
F
Paties
Carlo T
CT
Ferrarini
Marina
M
Sarmati
Loredana
L
Praderio
Luisa
L
Sabbadini
Maria Grazia
MG
Lusso
Paolo
P
Malnati
Mauro S
MS
D001168:Arthritis / Q000821:virology*; D004279:DNA, Viral / Q000097:blood; D004487:Edema / Q000821:virology; D005076:Exanthema / Q000821:virology; D005260:Female; D018023:HIV Seronegativity; D006566:Herpesviridae Infections / Q000150:complications*; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D007121:Immunocompetence; D008198:Lymph Nodes / Q000473:pathology / Q000821:virology; D008206:Lymphatic Diseases / Q000821:virology*; D008875:Middle Aged; D012008:Recurrence; D012514:Sarcoma, Kaposi / Q000150:complications; D013163:Splenomegaly / Q000821:virology; D013585:Synovitis / Q000821:virology*; D019562:Viral Load
D004279:DNA, Viral