Study on interaction of gastrointestinal agents in the presence of cytoprotective drugs. Part III. In vitro study on the adsorption of selected prokinetic drugs on sucralfate.
Adsorbance of certain prokinetic drugs, regulating the motility of the digestive tract, on a cytoprotective drug--sucralfate was investigated. The evaluation of adsorbance capability was carried out by means of a statistical method in in vitro conditions, taking into account environmental pH, concentration of the investigated drugs as well as the form of sucralfate. Obtained results prove that the analyzed active agents are adsorbed on sucralfate at all the investigated pH ranges and the capability of sucralfate binding depends on its form and environmental pH. The highest binding capability was revealed by samples with pH = 3.6 in the presence of sucralfate in the form of suspension, while the lowest binding capability was observed at pH = 1.5 in the presence of sucralfate in the form of paste. The adsorbance capacity of sucralfate (k) at pH = 3.6 is the highest for cisaprid (k = 8.5) and it is significantly lower for metoclopramide (k = 1.5)
Grimling
Bozena
B
Department of Applied Pharmacy, Medical University of Wrocław, 38 Szewska Str., 50-139 Wrocław, Poland.
Pluta
Janusz
J
D000327:Adsorption; D000897:Anti-Ulcer Agents / Q000737:chemistry*; D000932:Antiemetics / Q000737:chemistry; D020117:Cisapride / Q000737:chemistry; D005765:Gastrointestinal Agents / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008787:Metoclopramide / Q000737:chemistry; D013392:Sucralfate / Q000737:chemistry*; D013816:Thermodynamics
D000897:Anti-Ulcer Agents; D000932:Antiemetics; D005765:Gastrointestinal Agents; D013392:Sucralfate; D008787:Metoclopramide; D020117:Cisapride