Pathological oscillatory coupling within the human motor system in different tremor syndromes as revealed by magnetoencephalography.
Whole-head MEG-systems and modern spatial-filter-based analysis tools recently provided new possibilities to analyze non-invasively cerebral networks of human tremor syndromes. We compared tremor syndromes in Parkinsonian patients with a typical resting tremor as well as in patients with hepatic encephalopathy (HE) with a postural tremor called "mini-asterixis". In 6 patients with idiopathic Parkinson's disease (PD) we found strong coherence between the electromyography (EMG) of forearm muscles and activity in the contralateral primary motor cortex (M1) at tremor frequency but also at double tremor frequency. Furthermore, significant coherences were observed between M1 and medial wall areas (CMA/SMA), lateral premotor cortex, diencephalon, SII cortex, posterior parietal cortex and the contralateral cerebellum at tremor and, stronger, at double tremor frequency. In contrast, in 6 patients with "mini-asterixis" and HE due to chronic liver cirrhosis excessive corticomuscular coherence occurred at the individual tremor frequency between EMG and M1 activity. Interestingly, thalamus-M1 coupling was significantly altered towards lower frequencies matching the individual frequency of the mini-asterixis. Cerebro-muscular or cerebro-cerebral coupling at double tremor frequency was not observed. Therefore, "mini-asterixis" reflects most likely a pathologically decelerated and augmented synchronized rhythmical motor cortical output. This could be due to functional alterations in the M1-basal-ganglia-thalamo-cortical loops in severe HE. In summary, tremor syndromes in PD as well as in patients with HE and "mini-asterixis" are characterized by pathological oscillatory activity within cerebral networks of motor areas. However, the present study shows different mechanisms of tremor generation in PD and HE patients.
Timmermann
L
L
Department of Neurology and Gastroenterology, University Hospital Düsseldorf, Germany. timmermann@neurologie.uni-duesseldorf.de
Gross
J
J
Butz
M
M
Kircheis
G
G
Haussinger
D
D
Schnitzler
A
A
D019054:Evoked Potentials, Motor / Q000502:physiology*; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods*; D010300:Parkinson Disease / Q000175:diagnosis / Q000503:physiopathology; D013577:Syndrome; D014202:Tremor / Q000175:diagnosis* / Q000503:physiopathology*