Anti-TWEAK monoclonal antibodies reduce immune cell infiltration in the central nervous system and severity of experimental autoimmune encephalomyelitis.
TWEAK is a member of the TNF family, constitutively expressed in the central nervous system (CNS), with pro-inflammatory, proliferative or apoptotic effects depending upon cell types. Its receptor, Fn14, is expressed in CNS by endothelial cells, reactive astrocytes and neurons. We showed that TWEAK and Fn14 mRNA expression increased in spinal cord during experimental autoimmune encephalomyelitis (EAE). We investigated the role of TWEAK during EAE using neutralizing anti-TWEAK antibody in myelin oligodendrocyte glycoprotein (MOG) induced EAE in C57BL/6 mice. We observed a reduction of disease severity and leukocyte infiltration when mice were treated after the priming phase.
Desplat-Jégo
Sophie
S
Université de la Méditerranée, NICN, CNRS UMR 6184, IFR Jean Roche, Marseille, France.
Creidy
Rita
R
Varriale
Simone
S
Allaire
Normand
N
Luo
Yi
Y
Bernard
Dominique
D
Hahm
Kyungmin
K
Burkly
Linda
L
Boucraut
José
J
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D051017:Apoptosis Regulatory Proteins; D001253:Astrocytes / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D002352:Carrier Proteins / Q000276:immunology* / Q000378:metabolism; D002465:Cell Movement / Q000187:drug effects; D002478:Cells, Cultured; D000074049:Cytokine TWEAK; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D051379:Mice; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013116:Spinal Cord / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013997:Time Factors; D048069:Tumor Necrosis Factors
D000911:Antibodies, Monoclonal; D051017:Apoptosis Regulatory Proteins; D002352:Carrier Proteins; D000074049:Cytokine TWEAK; C491645:Tnfsf12 protein, mouse; D048069:Tumor Necrosis Factors