title: Association study between the D10S1423 microsatellite marker and Alzheimer's disease.
abstract: Several studies have reported conflicting results concerning the genetic association between Alzheimer's disease (AD) and the microsatellite marker D10S1423 on chromosome 10p12-14. In an ethnically homogeneous German population of 422 patients with AD and 254 cognitively healthy controls, the 238-bp allele of the D10S1423 marker showed a weak, but after correction for multiple testing no longer significant association with AD (p = 0.015, uncorrected; p = 0.11, corrected). These findings do not support the presence of a relevant susceptibility locus for AD on chromosome 10p12-14.
authors: Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universität München (TUM), Ismaningerstr. 22, D-81675 Munich, Germany.
authors: H
authors: H
authors: Gohlke
authors: T
authors: T
authors: Illig
authors: N
authors: N
authors: Klopp
authors: S
authors: S
authors: Wagenpfeil
authors: L
authors: L
authors: Konta
authors: S M
authors: SM
authors: Laws
authors: A
authors: A
authors: Kurz
authors: M
authors: M
authors: Riemenschneider
mesh_terms: D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E