title: [Effects of Huatan Xiezhuo Recipe on insulin resistance and leptin in rats with fatty liver].
abstract: OBJECTIVE
  To observe the effects of Huatan Xiezhuo Recipe (HTXZR) on fatty liver of rats.
  
  
  METHODS
  Forty-eight SD rats were randomly divided into five groups: normal control group, untreated group, Dongbao Gantai Tablet (DBGTT)-treated group, low-dose HTXZR-treated group and high-dose HTXZR-treated group. Fatty liver was induced in the rats by hyperlipid diet and intraperitoneal injection of tetracycline. The pathological changes of liver tissues in rats were observed, and the liver function, serum leptin, insulin resistance index, triglyceride (TG) and free fatty acid (FFA) in the liver were detected.
  
  
  RESULTS
  The levels of serum leptin, insulin resistance index, FFA and TG in rats of the three treated groups were lower than those of the untreated group (P<0.01), and such effects in the HTXZR-treated groups were more significant than those in the DBGTT-treated group (P<0.05).
  
  
  CONCLUSIONS
  The main action mechanisms of HTXZR in treating fatty liver are probably to promote the lipid metabolism, decrease the leptin and insulin resistance.
authors: First Clinical College, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu Province 210029, China.
authors: Fang
authors: F
authors: Ye
authors: Wen-Xia
authors: WX
authors: Zhao
authors: Ming-San
authors: MS
authors: Miao
authors: Jian-Guo
authors: JG
authors: Li
authors: Yong-Yan
authors: YY
authors: Zhang
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005234:Fatty Liver / Q000188:drug therapy* / Q000378:metabolism; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D008297:Male; D008517:Phytotherapy; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004365:Drugs, Chinese Herbal; D005230:Fatty Acids, Nonesterified; D020738:Leptin