title: Low plasma HLA-G protein concentrations in early gestation indicate the development of preeclampsia later in pregnancy.
abstract: OBJECTIVE
  The aim of this study was to determine whether circulating HLA-G levels, early in pregnancy, predict the subsequent development of preeclampsia (PE).
  
  
  METHODS
  Plasma samples, collected longitudinally during the first, second, and third trimesters, from 12 PE patients and 12 matched control patients were tested for HLA-G protein using a validated sandwich ELISA.
  
  
  RESULTS
  First and second trimester HLA-G levels in PE were significantly lower than in control patients (first trimester, 1.25 microg/mL vs 1.95 microg/mL, P=.029; second trimester, 1.11 microg/mL vs 1.90 microg/mL, P=.024).
  
  
  CONCLUSIONS
  Our results indicate that HLA-G levels in plasma from women who subsequently develop PE are lower than control patients, as early as the first trimester. This suggests that determination of circulating HLA-G protein concentration may be useful as an early predictor for the development of PE.
authors: Department of Obstetrics and Gynecology, Sunnybrook and Women's College Health Sciences Centre (SWCHSC), Toronto, Ontario, Canada.
authors: Shang-mian
authors: SM
authors: Yie
authors: Robert N
authors: RN
authors: Taylor
authors: Clifford
authors: C
authors: Librach
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006680:HLA Antigens / Q000097:blood*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000097:blood*; D006801:Humans; D008137:Longitudinal Studies; D009994:Osmolar Concentration; D011225:Pre-Eclampsia / Q000209:etiology*; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood*; D011262:Pregnancy Trimester, Second / Q000097:blood; D011263:Pregnancy Trimester, Third / Q000097:blood; D011446:Prospective Studies
chemical_list: D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I