Vinylpyrrolidone-co-(meth)acrylic acid inserts for ocular drug delivery: synthesis and evaluation.
Copolymeric hydrogels constituting of vinylpyrrolidone and methacrylic or acrylic acid repeat units have been prepared and investigated for their ability to act as controlled release vehicles in ophthalmic drug delivery. The materials were synthesized by radical-induced polymerization in the presence of N,N'-methylenebisacrylamide crosslinker, and the influences of network composition and drug solubility upon the swelling properties, adhesion behavior, and drug release characteristics were studied. In vitro release experiments showed that some of these materials could be useful vehicles for the delivery of drugs such as pilocarpine or chloramphenicol, while in vivo studies, using the rabbit model, confirmed their high potential for the controlled ocular delivery of pilocarpine hydrochloride.
Barbu
Eugen
E
School of Pharmacy and Biomedical Sciences, University of Portsmouth, St. Michael's Building, White Swan Road, Portsmouth P01 2DT, UK.
Sarvaiya
Indrajeetsinh
I
Green
Keith L
KL
Nevell
Thomas G
TG
Tsibouklis
John
J
D000818:Animals; D002701:Chloramphenicol / Q000493:pharmacokinetics; D004195:Disease Models, Animal; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics*; D004341:Drug Evaluation; D005123:Eye; D005128:Eye Diseases / Q000188:drug therapy; D008297:Male; D008689:Methacrylates / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D018721:Muscarinic Agonists / Q000008:administration & dosage / Q000493:pharmacokinetics*; D010862:Pilocarpine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics*; D011760:Pyrrolidinones / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D011817:Rabbits
D004337:Drug Carriers; D008689:Methacrylates; D018721:Muscarinic Agonists; D011108:Polymers; D011760:Pyrrolidinones; D010862:Pilocarpine; C008384:methacrylic acid; D002701:Chloramphenicol