title: Early neuropsychological evaluation in patients with ischaemic stroke provides valid information.
abstract: OBJECTIVE
  This study describes the feasibility and validity of neuropsychological evaluation in the early stage post-stroke. Early information on cognitive functioning in stroke patients could improve discharge decision, programming of rehabilitation strategies, and better prepare proxies for the problems they can be presented with in daily life. In this explorative study, our primary focus was on the feasibility of early neuropsychological evaluation. Furthermore, we looked at the possible prognostic relevance of early examination.
  
  
  METHODS
  Fifty-seven consecutive patients (age 19-80) were enrolled within 4-20 days after their first ischaemic stroke (Modified-Rankin Scale (M-RS): 2-4). Patients were re-tested after 12-24 months, and functional outcome was assessed.
  
  
  RESULTS
  In the early stage 44 (77%), patients could complete 82% of the administered tasks. At second evaluation, test performances improved, but a stable test profile was found with respect to abnormalities on the different tasks (P<0.0001). Moreover, initial sum scores of all composite cognitive domains including intellectual functioning (R2=0.80), language (R2=0.76), memory (R2=0.32), perception and visuospatial construction (R2=0.60), attention and psychomotor-functioning (R2=0.80) had significant predictive validity with respect to functional outcome (P<0.001).
  
  
  CONCLUSIONS
  This study supports the feasibility of early neuropsychological evaluation after ischaemic stroke onset and the prognostic validity for cognitive outcome in the long term.
authors: Helmholtz Instituut, Psychological Laboratory, Utrecht University, Heidelberglaan 2, NL-3584 CS Utrecht, The Netherlands. m.j.e.vanzandvoort@fss.uu.nl
authors: M J E
authors: MJ
authors: van Zandvoort
authors: R P C
authors: RP
authors: Kessels
authors: G M S
authors: GM
authors: Nys
authors: E H F
authors: EH
authors: de Haan
authors: L J
authors: LJ
authors: Kappelle
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000150:complications* / Q000523:psychology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology*; D042241:Early Diagnosis; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D011379:Prognosis; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D020521:Stroke / Q000209:etiology* / Q000523:psychology*; D013997:Time Factors