title: Octyl 2-cyanoacrylate for repair of peripheral nerve.
abstract: The repair of peripheral nerves with sutures is time consuming. The aim of this study was to evaluate the benefits and functional outcome of repairing nerves with octyl 2-cyanoacrylate adhesive. The right peroneal nerve of 64 male, Lewis rats was sectioned and repaired. The rats were randomized into 3 experimental groups: A (n = 27), using only octyl 2-cyanoacrylate; B (n = 27), using 4, 10-0 nylon sutures; and C (n = 10), a sham operation. The recovery of nerve function was quantified through walking-track analyses; group A showed faster return of nerve function than B, especially at 15 days (P < 0.017). Histologic analysis showed a greater axonal regeneration in group A versus group B and no indication of tissue toxicity in group A. No dehiscence occurred during the 6-month study. Use of adhesive shortened the anastomosis time from 12 minutes to 4 minutes. These results indicate that the use of octyl 2-cyanoacrylate adhesive for nerve anastomoses is safe and effective and may have benefits compared with the use of sutures.
authors: Department of Plastic Surgery, University of Virginia Health System, Charlottesville, VA 22903-1351, USA.
authors: Angela
authors: A
authors: Piñeros-Fernández
authors: Pamela F
authors: PF
authors: Rodeheaver
authors: George T
authors: GT
authors: Rodeheaver
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D003487:Cyanoacrylates / Q000627:therapeutic use*; D008124:Locomotion; D008297:Male; D010543:Peroneal Nerve / Q000166:cytology / Q000502:physiology / Q000601:surgery*; D011897:Random Allocation; D051381:Rats; D011917:Rats, Inbred Lew; D019651:Plastic Surgery Procedures / Q000379:methods*; D012038:Regeneration / Q000502:physiology
chemical_list: D003487:Cyanoacrylates; C100832:octyl 2-cyanoacrylate