The pathology of cellular anti-stress mechanisms: a new frontier.
Exposure to stressors is an omnipresent variable for all living organisms, which have evolved anti-stress mechanisms to deal with the consequences of stress. The chaperoning systems are among these mechanisms, and their central components are the molecular chaperones that play important roles in protein biogenesis. Recent data suggest that failure of the chaperoning systems due to defective chaperones, for example, leads to pathology. Consequently, medical researchers and practitioners must now also consider the chaperoning systems, both as potentially major players in pathogenesis and as diagnostic-prognostic indicators.
Macario
Alberto J L
AJ
Wadsworth Center, Division of Molecular Medicine, New York State Department of Health, The University at Albany (SUNY), Empire State Plaza, P.O. Box 509, Albany, New York 12201-0509, USA. macario@wadsworth.org
Conway de Macario
Everly
E
D000818:Animals; D006360:Heat-Shock Proteins / Q000502:physiology; D006801:Humans; D018832:Molecular Chaperones / Q000502:physiology; D013312:Stress, Physiological
D006360:Heat-Shock Proteins; D018832:Molecular Chaperones