title: Protective effects of a mixture of antioxidant vitamins and minerals on the genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster.
abstract: Antioxidant vitamins are able to deactivate highly bioactive molecules, such as free radicals, that are generated during cellular biochemical processes. Doxorubicin (DXR) is a cancer chemotherapeutic agent that generates free radicals as a byproduct. In the present study, the Drosophila melanogaster somatic wing spot test was used to evaluate the effects of a mixture of vitamins (Vitamins C, E, and beta-carotene) and minerals (copper, selenium, and zinc), commercially known as Vitergan Zinc Plus, on the genotoxicity of DXR in standard and high-bioactivation crosses of flies. 12.5, 25, and 50 mg/ml of the vitamin/mineral mixture by itself was nongenotoxic in the trans-heterozygous descendants of both crosses, while the mixture produced a significant reduction in the genotoxicity produced by 0.125 mg/ml DXR in the trans-heterozygous descendants of both crosses. The protective effect was observed when the larvae received either pre- or cotreatments of the multivitamin/mineral (MV) mixture. The results indicate that, under these experimental conditions, the MV mixture is not genotoxic; however, it protects against the genotoxic effects of the chemotherapeutic free-radical generator DXR.
authors: Instituto de Genética e Bioquímica, Universidade Federal de Uberlândia, Uberlândia (MG), Brazil.
authors: Wender Ferreira
authors: WF
authors: Costa
authors: Júlio César
authors: JC
authors: Nepomuceno
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D003300:Copper / Q000494:pharmacology; D004317:Doxorubicin / Q000633:toxicity*; D004331:Drosophila melanogaster / Q000033:anatomy & histology / Q000187:drug effects*; D005260:Female; D007814:Larva / Q000033:anatomy & histology / Q000187:drug effects; D008297:Male; D009153:Mutagens / Q000633:toxicity; D009154:Mutation; D012643:Selenium / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology; D014921:Wings, Animal / Q000002:abnormalities / Q000187:drug effects; D015032:Zinc / Q000494:pharmacology; D019207:beta Carotene / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D009153:Mutagens; D019207:beta Carotene; D014810:Vitamin E; D003300:Copper; D004317:Doxorubicin; D012643:Selenium; D015032:Zinc; D001205:Ascorbic Acid