[Study of the disease burden of patients with drug-resistant and drug-sensitive tuberculosis in Guangdong and Zhejiang provinces].
OBJECTIVE
To investigate the disease burden of drug-resistant and drug-sensitive tuberculosis (TB) patients in Guangdong and Zhejiang provinces.


METHODS
Three hundred and two patients with TB, who had been involved in the project for drug resistance surveillance and completed the full course of treatment, were enrolled for this study. The proportion method for drug susceptibility was used. The method of disability adjusted life year (DALY) was applied to assess the disease burden of TB patients.


RESULTS
The average DALYs of initial cases with drug-sensitive and drug-resistant TB, and retreated cases with drug-sensitive and drug-resistant TB, were 0.26, 0.68, 0.49, and 1.04, respectively. The average DALY loss of drug-resistant TB patients was 0.86 and that of drug-sensitive TB patients was 0.44.


CONCLUSIONS
The values of DALY for initial and retreated cases with drug-resistant TB were 2 times higher than those for patients with drug-sensitive TB, indicating the higher disease burden in drug-resistant TB patients. Therefore, to reduce the disease burden of patients with drug-resistant TB, standardized protocols must be applied in the treatment of TB.
Duanmu
Hong-jin
HJ
Tuberculosis Prevention and Medicine Centre, Chinese Disease Prevention and Control Centre, Beijing101149, China.
Gong
You-long
YL
Wu
Gui-ying
GY
Wang
Xue-jing
XJ
Zhong
Qiu
Q
Li
Qun
Q
Li
Feng-ru
FR
D000995:Antitubercular Agents / Q000494:pharmacology; D002681:China / Q000453:epidemiology; D017281:Cost of Illness; D006801:Humans; D012494:Sampling Studies; D018088:Tuberculosis, Multidrug-Resistant / Q000191:economics* / Q000453:epidemiology; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000191:economics* / Q000453:epidemiology
D000995:Antitubercular Agents