Indium triflate-catalyzed vinylation of beta-ketoesters with acetylene gas.
[reaction: see text]. An In(OTf)(3)-catalyzed addition of a beta-ketoester to acetylene in the presence of molecular sieves produces a alpha-vinylated ketoester in good to excellent yield. The vinylation reaction proceeds without any loss of elements in starting molecules under solvent-free conditions and allows the use of welding-grade acetylene, providing a practical method for synthetic utilization of acetylene gas.
Nakamura
Masaharu
M
Department of Chemistry, The University of Tokyo, Hongo, Bunkyo-ku, Japan.
Endo
Kohei
K
Nakamura
Eiichi
E