title: Boronolectins and fluorescent boronolectins: an examination of the detailed chemistry issues important for the design.
abstract: Glycans in the form of glycoproteins or glycolipids play very critical roles in various biological and pathological processes including inflammation, cancer metastasis, immune reactions, embryo development, cell-cell communications and adhesions, blood generation, etc. Proteins (lectins) that can recognize carbohydrates have played very important roles in studying glycobiology. Small molecule mimics of lectins will be very useful in the development of new therapeutics and diagnostics. Along this line, boronic acids have been widely used in the design and synthesis of small organic compounds that mimic the function of lectins. This review examines in detail the factors that are important for the design of boronic acid-based lectin mimics, boronolectins.
authors: Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA 30302-4089, USA.
authors: Jun
authors: J
authors: Yan
authors: Hao
authors: H
authors: Fang
authors: Binghe
authors: B
authors: Wang
mesh_terms: D000818:Animals; D001895:Boron / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry; D015195:Drug Design; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D037102:Lectins / Q000737:chemistry*
chemical_list: D001897:Boronic Acids; D005456:Fluorescent Dyes; D037102:Lectins; D001895:Boron