title: History of migraine and the risk of spontaneous cervical artery dissection.
abstract: The pathophysiology of spontaneous cervical artery dissection (sCAD) is largely unknown. An association with migraine has been suggested, but not definitively proven. In the setting of a hospital-based prospective case-control study we assessed personal and family history of migraine in 72 patients with sCAD, 72 patients with cerebral infarct unrelated to a CAD (non-CAD) and 72 control subjects. Personal history of migraine was significantly associated to sCAD compared to non-CAD (59.7% vs. 30.6%; OR 3.14; 95% CI 1.41-7.01) and controls (18.1%; OR 7.41; 95% CI 3.11-17.64). As opposed to migraine with aura, migraine without aura was significantly more frequent among sCAD than among non-CAD (56.9% vs. 25.0%; OR 3.91; 95% CI 1.71-8.90) and controls (12.5%; OR 9.84; 95% CI 3.85-25.16). Similar results were observed when the frequencies of family history of migraine were compared. These findings are consistent with the hypothesis that migraine may represent a predisposing condition for sCAD.
authors: Clinica Neurologica, Università degli Studi di Brescia, Brescia, Italy. ale_pezzini@hotmail.com
authors: A
authors: A
authors: Pezzini
authors: F
authors: F
authors: Granella
authors: M
authors: M
authors: Grassi
authors: C
authors: C
authors: Bertolino
authors: E
authors: E
authors: Del Zotto
authors: P
authors: P
authors: Immovilli
authors: E
authors: E
authors: Bazzoli
authors: A
authors: A
authors: Padovani
authors: C
authors: C
authors: Zanferrari
mesh_terms: D000328:Adult; D000784:Aortic Dissection / Q000150:complications*; D001158:Arteries / Q000473:pathology; D001921:Brain / Q000098:blood supply*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications*; D011446:Prospective Studies; D012307:Risk Factors; D020521:Stroke / Q000209:etiology