title: Evaluation of the effect of dietary vegetable consumption on reducing risk of transitional cell carcinoma of the urinary bladder in Scottish Terriers.
abstract: OBJECTIVE
  To evaluate the effects of vegetable consumption and vitamin supplementation on the risk of developing transitional cell carcinoma (TCC) of the urinary bladder in Scottish Terriers.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  92 adult Scottish Terriers with TCC (cases) and 83 Scottish Terriers with other conditions (controls).
  
  
  METHODS
  Owners of dogs with TCC completed a questionnaire regarding their dogs' diet and intake of vitamin supplements in the year prior to diagnosis of TCC; owners of control dogs completed the questionnaire for a comparable time period. The risk (odds ratio [OR]) of developing TCC associated with diet and vitamin supplementation was determined by use of logistic regression.
  
  
  RESULTS
  After adjustment for age, weight, neuter status, and coat color, there was an inverse association between consumption of vegetables at least 3 times/wk (OR, 0.30; 95% confidence interval [CI], 0.15 to 0.62) and risk of developing TCC. For individual vegetable types, the risk of developing TCC was inversely associated with consumption of green leafy vegetables (OR, 0.12; 95% CI, 0.01 to 0.97) and yellow-orange vegetables (OR, 0.31; 95% CI, 0.14 to 0.70). Consumption of cruciferous vegetables was not significantly associated with a similar reduction in risk of developing TCC (OR, 0.22; CI, 0.04 to 1.11). The power of the study to detect a 50% reduction in TCC risk associated with daily vitamin supplementation was considered low (25%).
  
  
  CONCLUSIONS
  Results suggest that consumption of certain vegetables may prevent or slow the development of TCC in Scottish Terriers.
authors: Department of Veterinary Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907-2027, USA.
authors: Malathi
authors: M
authors: Raghavan
authors: Deborah W
authors: DW
authors: Knapp
authors: Patty L
authors: PL
authors: Bonney
authors: Marcia H
authors: MH
authors: Dawson
authors: Lawrence T
authors: LT
authors: Glickman
mesh_terms: D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D002295:Carcinoma, Transitional Cell / Q000453:epidemiology / Q000517:prevention & control / Q000662:veterinary*; D016022:Case-Control Studies; D016001:Confidence Intervals; D004283:Dog Diseases / Q000178:diet therapy / Q000453:epidemiology* / Q000517:prevention & control; D004285:Dogs; D005260:Female; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D012307:Risk Factors; D013045:Species Specificity; D011795:Surveys and Questionnaires; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology / Q000517:prevention & control / Q000662:veterinary*; D014675:Vegetables; D014815:Vitamins / Q000008:administration & dosage
chemical_list: D014815:Vitamins