Hypocretin-1 (orexin A) deficiency in acute traumatic brain injury.
Hypocretin-1 is involved in the regulation of the sleep-wake cycle. The authors prospectively assessed CSF hypocretin-1 levels in 44 consecutive patients with acute traumatic brain injury (TBI). Compared with controls, hypocretin-1 levels were abnormally lower in 95% of patients with moderate to severe TBI and in 97% of patients with posttraumatic brain CT changes. Hypocretin-1 deficiency after TBI may reflect hypothalamic damage and be linked with the frequent development of posttraumatic sleep-wake disorders.
Baumann
C R
CR
Department of Neurology, University Hospital, Zürich, Switzerland.
Stocker
R
R
Imhof
H-G
HG
Trentz
O
O
Hersberger
M
M
Mignot
E
E
Bassetti
C L
CL
D000293:Adolescent; D000328:Adult; D000368:Aged; D001341:Autonomic Nervous System / Q000378:metabolism / Q000503:physiopathology; D001831:Body Temperature / Q000502:physiology; D001930:Brain Injuries / Q000134:cerebrospinal fluid / Q000150:complications* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007026:Hypothalamic Area, Lateral / Q000378:metabolism / Q000503:physiopathology; D007027:Hypothalamic Diseases / Q000134:cerebrospinal fluid / Q000209:etiology* / Q000503:physiopathology; D007031:Hypothalamus / Q000378:metabolism / Q000503:physiopathology*; D007034:Hypothalamus, Posterior / Q000378:metabolism / Q000503:physiopathology; D047908:Intracellular Signaling Peptides and Proteins / Q000134:cerebrospinal fluid / Q000172:deficiency / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000378:metabolism / Q000503:physiopathology; D009479:Neuropeptides / Q000134:cerebrospinal fluid / Q000172:deficiency / Q000378:metabolism*; D000068797:Orexins; D011446:Prospective Studies; D012890:Sleep / Q000502:physiology; D012893:Sleep Wake Disorders / Q000134:cerebrospinal fluid / Q000209:etiology* / Q000503:physiopathology; D014851:Wakefulness / Q000502:physiology
C000596229:HCRT protein, human; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins