title: Primary hepatic anaplastic large-cell lymphoma diagnosed by fine-needle aspiration biopsy.
abstract: Anaplastic large-cell lymphoma (ALCL) presenting as primary hepatic lymphoma is exceedingly rare. Here, we report a case of primary hepatic ALCL, which was diagnosed by cytologic evaluation and concurrent immunohistochemical studies on the material obtained by fine-needle aspiration biopsy. The aspirate smears revealed many loosely dispersed, large atypical cells, some of them with kidney-/horseshoe-shaped and doughnut-shaped nuclei and abundant amphophilic cytoplasm. The nuclei in some of the other cells were often eccentrically located and appeared to be convoluted and even multilobulated. These large atypical cells displayed T-cell immunophenotype and were immunoreactive with CD30 antibody. The diagnosis was confirmed by a core-needle biopsy. This is the first case of primary hepatic ALCL reported in the English cytological literature.
authors: Department of Pathology, New York University Medical Center, NY 10016, USA.
authors: Guoping
authors: G
authors: Cai
authors: Giorgio
authors: G
authors: Inghirami
authors: Andre
authors: A
authors: Moreira
authors: Filiz
authors: F
authors: Sen
mesh_terms: D000328:Adult; D044963:Biopsy, Fine-Needle; D006679:HIV Seropositivity / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D017730:Ki-1 Antigen / Q000378:metabolism; D008113:Liver Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D008297:Male
chemical_list: D017730:Ki-1 Antigen