In vivo diffusion weighted 19F MRI using SF6.
Diffusion weighted 19F images of rat lung in vivo using SF6 are presented. Projection-reconstruction images were acquired by filling the rat lung with a mixture of SF6 and air, during 64 successive apneas. Each apnea lasted for 6 s, the time required to perform 100 accumulations of each k-space radial phase step for the five values of the diffusion gradient (TR = 10 ms). After diffusion images were acquired, an apparent diffusion coefficient (ADC) map was generated, yielding an average value for the ADC of 2.22 x 10(-6) m2/s and SD for ADC values of 1.27 x 10(-6) m2/s. To the best of our knowledge, this is the first in vivo diffusion weighting imaging application and the first ADC map obtained using 19F MRI.
Pérez-Sánchez
José M
JM
Instituto de Estudios Biofuncionales. Universidad Complutense de Madrid, Madrid, Spain. iosephus@ieb.ucm.es
Pérez de Alejo
Rigoberto
R
Rodríguez
Ignacio
I
Cortijo
Manuel
M
Peces-Barba
Germán
G
Ruiz-Cabello
Jesús
J
D000280:Administration, Inhalation; D000818:Animals; D016009:Chi-Square Distribution; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005461:Fluorine; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted; D008168:Lung / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013459:Sulfur Hexafluoride / Q000008:administration & dosage*
D005461:Fluorine; D013459:Sulfur Hexafluoride