Partners for adenosine A1 receptors.
G protein-coupled receptors (GPCRs) are targets for therapy in a variety of neurological diseases. Using adenosine A1 receptors (A1Rs) as paradigm of GPCRs, this review focuses on how protein-protein interactions, from monomers to heteromers, can contribute to hormone/neurotransmitter/neuromodulator regulation. The interaction of A1Rs with other membrane receptors, enzymes, and adaptor and scaffolding proteins is relevant for receptor traffic, internalization, and desensitization, and A1Rs are extremely important in driving signaling through different intracellular pathways. There is even the possibility of linking together GPCR heteromeric complexes with ion channel receptors in a receptor mosaic that might have special integrative value and might constitute the molecular basis for learning and memory.
Franco
Rafael
R
Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain. rfranco@ub.edu
Ciruela
Francisco
F
Casadó
Vicent
V
Cortes
Antonio
A
Canela
Enric I
EI
Mallol
Josefa
J
Agnati
Luigi F
LF
Ferré
Sergi
S
Fuxe
Kjell
K
Lluis
Carmen
C
D000243:Adenosine Deaminase / Q000378:metabolism; D000818:Animals; D006801:Humans; D046911:Macromolecular Substances / Q000737:chemistry / Q000378:metabolism; D009422:Nervous System Diseases / Q000188:drug therapy; D018377:Neurotransmitter Agents / Q000494:pharmacology / Q000627:therapeutic use; D043682:Receptor, Adenosine A1 / Q000737:chemistry / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000378:metabolism
D046911:Macromolecular Substances; D018377:Neurotransmitter Agents; D043682:Receptor, Adenosine A1; D043562:Receptors, G-Protein-Coupled; D000243:Adenosine Deaminase