Encouraging results despite complexity of multidisciplinary care of HIV-infected women using assisted reproduction techniques.
BACKGROUND
Assisted reproduction technologies can treat infertility for human immunodeficiency virus (HIV) seropositive women. We assessed the efficacy of these techniques in the results and difficulties encountered while conducting our assisted reproduction programme for 49 couples in which at least the woman had HIV infection that was currently under control.


METHODS
Treatments included intrauterine insemination (IUI), IVF and ICSI, with ovarian stimulation. Embryos were transferred on day 3 after oocyte retrieval. An elective single transfer was performed, except for patients aged > or = 40 years.


RESULTS
The median age of the women was 36 years. Ten IUI, nine IVF, 53 ICSI and 10 frozen-thawed embryo transfers have been performed. No pregnancy occurred following the IUI trials but for the couples with IVF and ICSI attempts the clinical pregnancy rate per embryo transfer was 23.9%. Eight babies have been born leading to a 22.2% take home baby rate per treated couple. Contamination was not observed in any newborn.


CONCLUSIONS
Assisted reproduction technologies and particularly ICSI can provide HIV seropositive women with a safe means of mothering children. Results are encouraging when considering the age of the patients and a preferential single embryo transfer.
Ohl
Jeanine
J
Centre d'AMP de Strasbourg, Service de Gynécologie-Obstétrique, CMCO-SIHCUS, 19 rue Louis Pasteur--BP 120--67303 Schiltigheim. jeanine.ohl@sihcus.fr
Partisani
Marialuisa
M
Wittemer
Christiane
C
Lang
Jean-Marie
JM
Viville
Stéphane
S
Favre
Romain
R
D000328:Adult; D005260:Female; D006679:HIV Seropositivity / Q000503:physiopathology*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D007247:Infertility, Female / Q000628:therapy; D010062:Ovulation Induction; D010348:Patient Care Team; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000503:physiopathology*; D027724:Reproductive Techniques, Assisted; D020554:Sperm Injections, Intracytoplasmic; D017329:Triptorelin Pamoate / Q000627:therapeutic use
D017329:Triptorelin Pamoate