Olivomycin induces tumor cell apoptosis and suppresses p53-induced transcription.
Olivomycin (DNA-binding antibiotic) in nanomolar concentrations induces apoptosis of human tumor cells and inhibits p53-dependent transcription of the reporter gene (basal and induced by antitumor drugs). Olivomycin aglycon induces no cytotoxicity and does not block transcription.
Simonova
V S
VS
Institute of Carcinogenesis, N. N. Blokhin Oncological Research Center, Russian Academy of Medical Sciences, Russia.
Samusenko
A V
AV
Filippova
N A
NA
Tevyashova
A N
AN
Lyniv
L S
LS
Kulik
G I
GI
Chekhun
V F
VF
Shtil
A A
AA
D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002236:Carbohydrate Conformation; D045744:Cell Line, Tumor; D006801:Humans; D008969:Molecular Sequence Data; D009848:Olivomycins / Q000737:chemistry / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000502:physiology*; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*
D000903:Antibiotics, Antineoplastic; D016159:Tumor Suppressor Protein p53; D009848:Olivomycins