title: Inhibitory effect of clonidine on cholinergic transmission.
abstract: Equilibrium geometry and electronic structure of three local anesthetic molecules and clonidine were computed. It was shown that clonidine molecule could incorporate into local anesthetic binding centers in potential-operated Na+ channels and in ionic channels coupled to nicotinic cholinergic receptors. The modulatory effect of clonidine on contractile responses of skeletal muscle showed that blockade of Na+ channels and nicotinic cholinergic receptors is a part of its analgesic action.
authors: V. A. Almazov Cardiology Research Institute, Ministry of Health of the Russian Federation, St. Petersburg. katina@iephb.ru
authors: I E
authors: IE
authors: Katina
authors: G A
authors: GA
authors: Nasledov
authors: R S
authors: RS
authors: Khrustaleva
authors: B F
authors: BF
authors: Shchegolev
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000737:chemistry / Q000494:pharmacology; D000700:Analgesics / Q000737:chemistry* / Q000494:pharmacology*; D000779:Anesthetics, Local / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D003000:Clonidine / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D009119:Muscle Contraction / Q000187:drug effects; D018482:Muscle, Skeletal / Q000187:drug effects; D018733:Nicotinic Antagonists / Q000737:chemistry* / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D000316:Adrenergic alpha-Agonists; D000700:Analgesics; D000779:Anesthetics, Local; D018733:Nicotinic Antagonists; D003000:Clonidine