title: Comparative genomics of trypanosomatid parasitic protozoa.
abstract: A comparison of gene content and genome architecture of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles and disease pathology, revealed a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters. Many species-specific genes, especially large surface antigen families, occur at nonsyntenic chromosome-internal and subtelomeric regions. Retroelements, structural RNAs, and gene family expansion are often associated with syntenic discontinuities that-along with gene divergence, acquisition and loss, and rearrangement within the syntenic regions-have shaped the genomes of each parasite. Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont.
authors: Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. nelsayed@tigr.org
authors: Najib M
authors: NM
authors: El-Sayed
authors: Peter J
authors: PJ
authors: Myler
authors: Gaëlle
authors: G
authors: Blandin
authors: Matthew
authors: M
authors: Berriman
authors: Jonathan
authors: J
authors: Crabtree
authors: Gautam
authors: G
authors: Aggarwal
authors: Elisabet
authors: E
authors: Caler
authors: Hubert
authors: H
authors: Renauld
authors: Elizabeth A
authors: EA
authors: Worthey
authors: Christiane
authors: C
authors: Hertz-Fowler
authors: Elodie
authors: E
authors: Ghedin
authors: Christopher
authors: C
authors: Peacock
authors: Daniella C
authors: DC
authors: Bartholomeu
authors: Brian J
authors: BJ
authors: Haas
authors: Anh-Nhi
authors: AN
authors: Tran
authors: Jennifer R
authors: JR
authors: Wortman
authors: U Cecilia M
authors: UC
authors: Alsmark
authors: Samuel
authors: S
authors: Angiuoli
authors: Atashi
authors: A
authors: Anupama
authors: Jonathan
authors: J
authors: Badger
authors: Frederic
authors: F
authors: Bringaud
authors: Eithon
authors: E
authors: Cadag
authors: Jane M
authors: JM
authors: Carlton
authors: Gustavo C
authors: GC
authors: Cerqueira
authors: Todd
authors: T
authors: Creasy
authors: Arthur L
authors: AL
authors: Delcher
authors: Appolinaire
authors: A
authors: Djikeng
authors: T Martin
authors: TM
authors: Embley
authors: Christopher
authors: C
authors: Hauser
authors: Alasdair C
authors: AC
authors: Ivens
authors: Sarah K
authors: SK
authors: Kummerfeld
authors: Jose B
authors: JB
authors: Pereira-Leal
authors: Daniel
authors: D
authors: Nilsson
authors: Jeremy
authors: J
authors: Peterson
authors: Steven L
authors: SL
authors: Salzberg
authors: Joshua
authors: J
authors: Shallom
authors: Joana C
authors: JC
authors: Silva
authors: Jaideep
authors: J
authors: Sundaram
authors: Scott
authors: S
authors: Westenberger
authors: Owen
authors: O
authors: White
authors: Sara E
authors: SE
authors: Melville
authors: John E
authors: JE
authors: Donelson
authors: Björn
authors: B
authors: Andersson
authors: Kenneth D
authors: KD
authors: Stuart
authors: Neil
authors: N
authors: Hall
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002875:Chromosomes / Q000235:genetics; D019143:Evolution, Molecular; D022761:Gene Transfer, Horizontal; D017125:Genes, Protozoan; D018503:Genome, Protozoan; D023281:Genomics; D018320:Leishmania major / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D005810:Multigene Family; D009154:Mutation; D010802:Phylogeny; D018087:Plastids / Q000235:genetics; D020543:Proteome; D015800:Protozoan Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D011995:Recombination, Genetic; D018626:Retroelements; D013045:Species Specificity; D013559:Symbiosis; D026801:Synteny; D016615:Telomere / Q000235:genetics; D014346:Trypanosoma brucei brucei / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D014349:Trypanosoma cruzi / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism
chemical_list: D020543:Proteome; D015800:Protozoan Proteins; D018626:Retroelements