Clinical outcomes of 54 pelvic osteosarcomas registered by Japanese musculoskeletal oncology group.
BACKGROUND
To determine the clinical outcomes in patients with pelvic osteosarcoma, we reviewed the experience with 54 pelvic osteosarcoma patients.


METHODS
Thirty-five patients underwent surgical treatment with 30 undergoing limb salvage procedures and 5 requiring hemipelvectomies.


RESULTS
Oncological outcome was continuously disease free in 12 cases, no evidence of disease in 3, alive with disease in 3, died of disease in 34 and died of other causes in 2. The 5-year survival rate was 29.5%. For the patients who underwent surgery, statistically significant prognostic factors were chemotherapy, surgical margin, tumor location in sacrum, efficacy of chemotherapy, local recurrence, metastasis and treatment for metastases. With univariate analysis, local recurrence, surgical margin and tumors resected from the sacrum were significant prognostic factors for metastasis. Surgical margin, tumor resected from sacrum and metastasis were significant prognostic factors for local recurrence. With regard to postoperative functional mobility, patients with tumors resected from the sacrum exhibited poorer functional mobility when compared with other sites.


CONCLUSIONS
Patients with tumors located in the sacrum had worse prognosis, and significant prognostic factor for local recurrence and metastasis. Treatment of pelvic osteosarcoma especially located in the sacrum requires new approaches and further improvements in order to ensure successful outcomes.
Matsuo
Toshihiro
T
Department of Orthopaedic Surgery, Hiroshima University, Hiroshima, Japan. tmatsuo@hiroshima-u.ac.jp
Sugita
Takashi
T
Sato
Keiji
K
Hotta
Tetsuo
T
Tsuchiya
Hiroyuki
H
Shimose
Shoji
S
Kubo
Tadahiko
T
Ochi
Mitsuo
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000473:pathology* / Q000601:surgery; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000473:pathology* / Q000601:surgery; D010384:Pelvic Bones; D010386:Pelvic Neoplasms / Q000473:pathology* / Q000601:surgery; D011379:Prognosis; D012042:Registries; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome