title: Antiviral activity of liposomal preparations of antibiotic geliomycin.
abstract: A liposomal preparation with maximally possible content of incorporated geliomycin was obtained. Its cytotoxicity was studied in a culture of human embryonal diploid fibroblasts. Antiviral activity was studied on a model of cytomegaloviral infection in vitro by the capacity to plaque formation. Liposomal geliomycin was 10-fold less toxic for human cells than the solution of the antibiotic in DMSO and exhibited antiviral activity towards cytomegaloviral infection at a concentration of 0.042 microg/ml.
authors: M. V. Lomonosov Moscow State Academy of Fine Chemical Technology Russian Academy of Medical Sciences, Moscow.
authors: S V
authors: SV
authors: Podol'skaya
authors: N A
authors: NA
authors: Naryshkina
authors: G M
authors: GM
authors: Sorokoumova
authors: A P
authors: AP
authors: Kaplun
authors: N E
authors: NE
authors: Fedorova
authors: A A
authors: AA
authors: Medzhidova
authors: A A
authors: AA
authors: Kuts
authors: V I
authors: VI
authors: Shvets
mesh_terms: D000998:Antiviral Agents / Q000633:toxicity*; D001580:Benzopyrenes / Q000008:administration & dosage / Q000633:toxicity; D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008081:Liposomes; D010948:Viral Plaque Assay
chemical_list: D000998:Antiviral Agents; D001580:Benzopyrenes; D008081:Liposomes; C018379:resistomycin