title: Fluoridated milk for preventing dental caries.
abstract: BACKGROUND
  Dental caries remains a major public health problem in most industrialised countries, affecting 60% to 90% of school children and the vast majority of adults. Milk provides a relatively cost-effective vehicle for fluoride in the prevention of dental caries.
  
  
  OBJECTIVE
  To determine the effectiveness of fluoridated milk, as a means of delivering fluoride on a community basis, for preventing dental caries.
  
  
  METHODS
  We searched Cochrane Oral Health Group Trials Register (28 April 2005), Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 2, 2005), MEDLINE (1966 to 17 May 2005), OLDMEDLINE (1950 to 1965), EMBASE (1980 to 2005 week 20), LILACS (1982 to 17 May 2005), BBO (1986 to 17 May 2005), SIGLE (1980 to 17 May2005), Digital Dissertations (1861 to 17 May 2005) and reference lists of relevant articles. Attempts were made to identify both unpublished and ongoing studies. There were no language restrictions.
  
  
  METHODS
  Randomised or quasi-randomised controlled trials (RCTs), with an intervention or follow-up period of at least 3 years, comparing fluoridated milk with non-fluoridated milk. Primary outcome was change in caries experience, as measured by changes in decayed, missing and filled figures on tooth (dmft/DMFT) and surface (dmfs/DMFS).
  
  
  METHODS
  Inclusion decisions, data extraction and quality assessment were carried out independently and in duplicate. Study authors were contacted for additional information where necessary.
  
  
  RESULTS
  Two RCTs involving 353 children were included. For permanent teeth, after 3 years there was a significant reduction in the DMFT (78.4%, P < 0.05) between the test and control groups in one trial, but not in the other. The latter study only showed a significant reduction in the DMFT until the fourth (35.5%, P < 0.02) and fifth (31.2%,P < 0.05) years. For primary teeth, again there was a significant reduction in the dmft (31.3%, P< 0.05) between the test and control groups after 3 years in one study, but not in the other. The results could not be pooled because of the difference in concentration of fluoride in the milk.
  
  
  CONCLUSIONS
  There are insufficient studies with good quality evidence examining the effects of fluoridated milk in preventing dental caries. However, the included studies suggested that fluoridated milk was beneficial to school children, especially their permanent dentition. The data need to be supplemented by further RCTs to provide the highest level of evidence for practice.
authors: Unit of Dental Public Health, School of Dentistry, University of Manchester, Higher Cambridge Street, Manchester, UK, M15 6FH. albert.yeung@manchester.ac.uk
authors: C A
authors: CA
authors: Yeung
authors: J L
authors: JL
authors: Hitchings
authors: T V
authors: TV
authors: Macfarlane
authors: A G
authors: AG
authors: Threlfall
authors: M
authors: M
authors: Tickle
authors: A M
authors: AM
authors: Glenny
mesh_terms: D000818:Animals; D002327:Cariostatic Agents / Q000627:therapeutic use*; D002648:Child; D003731:Dental Caries / Q000517:prevention & control*; D005457:Fluoridation; D005459:Fluorides / Q000627:therapeutic use*; D006801:Humans; D008892:Milk; D016032:Randomized Controlled Trials as Topic
chemical_list: D002327:Cariostatic Agents; D005459:Fluorides