title: Behavioral and endocrine changes induced by perinatal fenvalerate exposure in female rats.
abstract: Pyrethroid insecticides have recently been linked to endocrine disruption. Endocrine disrupting chemicals have been defined as exogenous agents that interfere with the synthesis, secretion, binding, action, or elimination of natural hormones in the body. Previous research conducted in our laboratory suggests that perinatal exposure to fenvalerate, a type-II pyrethroid, interferes with brain sexual organization in male pups, probably acting on a critical perinatal hormone-related period. In the present study we investigate the effects of maternal exposure to fenvalerate (FV) during the prenatal and postnatal periods of sexual brain organization of female offspring. Behavioral (open-field, stereotyped and sexual behaviors), physical (sexual maturation, body and uterine weights), and neuroendocrine (estrous cycle and gonadal hormone levels ) parameters were assessed. Results show that 1) sexual maturation was delayed, albeit body weight was unchanged until adulthood; 2) there was a reduction in sexual behavior; 3) the estrous cycle was abnormal, and the uterine weight at different phases of the estrous cycle was modified; 4) gonadal hormone levels in the plasma were not affected, neither was stereotypy nor open-field behaviors. These results were attributed to an anti-estrogenic effect of perinatal exposure to FV during the critical periods of female brain sexual organization.
authors: Faculty of Biological, Exact and Experimental Sciences, Presbiterian Mackenzie University, São Paulo, Brazil.
authors: A C
authors: AC
authors: Moniz
authors: P E
authors: PE
authors: Cruz-Casallas
authors: S A
authors: SA
authors: Salzgeber
authors: F M F
authors: FM
authors: Varoli
authors: H S
authors: HS
authors: Spinosa
authors: M M
authors: MM
authors: Bernardi
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D004703:Endocrine System / Q000187:drug effects* / Q000502:physiology; D004967:Estrogens / Q000097:blood; D030762:Estrous Cycle / Q000187:drug effects; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D049690:History, Ancient; D007306:Insecticides / Q000633:toxicity*; D008124:Locomotion / Q000187:drug effects; D008297:Male; D009570:Nitriles / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011374:Progesterone / Q000097:blood; D011722:Pyrethrins / Q000633:toxicity*; D011863:Radioimmunoassay / Q000379:methods; D051381:Rats; D012726:Sexual Behavior, Animal / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects; D013997:Time Factors; D014599:Uterus / Q000187:drug effects
chemical_list: D004967:Estrogens; D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; D011374:Progesterone; C017690:fenvalerate