title: Effects of carvedilol upon intra- and interventricular synchrony in patients with chronic heart failure.
abstract: Radionuclide isotopic ventriculography with phase analysis was performed in 30 patients with stable heart failure (HF), determining left ventricular (LV) and interventricular contraction synchrony at baseline and after 6 months of treatment with maximal tolerated doses of carvedilol. Patients with HF had significant ventricular dyssynchrony compared with a normal population. The 50th percentile of patients with the greatest dyssynchrony at baseline showed significant improvement in ventricular synchrony after receiving carvedilol, and this was correlated positively with a reduction in end-diastolic LV volumes.
authors: Faculty of Medicine, P. Catholic University of Chile, University of Chile, Santiago, Chile. pcastro@med.puc.cl
authors: Pablo F
authors: PF
authors: Castro
authors: Paul
authors: P
authors: Mc-Nab
authors: Juan Carlos
authors: JC
authors: Quintana
authors: Alex
authors: A
authors: Bittner
authors: Douglas
authors: D
authors: Greig
authors: Ismael
authors: I
authors: Vergara
authors: José Luis
authors: JL
authors: Vukasovic
authors: Ramón
authors: R
authors: Corbalan
authors: Miguel
authors: M
authors: Copaja
authors: Guillermo
authors: G
authors: Díaz-Araya
authors: Mario
authors: M
authors: Chiong
authors: Rodrigo
authors: R
authors: Troncoso
authors: Hernán
authors: H
authors: Alcaino
authors: Sergio
authors: S
authors: Lavandero
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D002227:Carbazoles / Q000008:administration & dosage*; D000077261:Carvedilol; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004562:Electrocardiography; D005260:Female; D006333:Heart Failure / Q000175:diagnosis* / Q000188:drug therapy* / Q000401:mortality; D006334:Heart Function Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011412:Propanolamines / Q000008:administration & dosage*; D011446:Prospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D015996:Survival Rate; D016896:Treatment Outcome; D016277:Ventricular Function, Left / Q000187:drug effects; D020257:Ventricular Remodeling / Q000187:drug effects*
chemical_list: D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D011412:Propanolamines; D000077261:Carvedilol