Nitric oxide in the A5 region modulates reaction of the respiratory center and blood pressure to hypoxia in rats.
Hypoxia was followed by more pronounced activation of the respiratory center and pronounced hypotensive response after unilateral injection of nitric oxide synthase blocker L-NAME into the A5 region. Microinjection of exogenous nitric oxide donor sodium nitroprusside into the A5 region abolished the effect of L-NAME on hypoxia-induced changes in activity of the respiratory center and blood pressure. Bilateral transection of the vagal and sinocarotid nerves suppressed the response of the respiratory center to hypoxia. However, the hypotensive response to hypoxia in these rats did not differ from that in intact animals. Under conditions of peripheral chemoreceptor deafferentation, the hypotensive response to hypoxia did not differ before and after blockade of nitric oxide synthase in the A5 region. The regulation of respiratory center activity and blood pressure during hypoxia was modulated by A5 neurons with the involvement of nitric oxide.
Pyatin
V F
VF
Department of Normal Physiology, Samara State Medical University.
Tatarnikov
V S
VS
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D000860:Hypoxia / Q000503:physiopathology*; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009569:Nitric Oxide / Q000494:pharmacology / Q000502:physiology*; D020030:Nitric Oxide Donors / Q000494:pharmacology; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D009599:Nitroprusside / Q000494:pharmacology; D051381:Rats; D012125:Respiratory Center / Q000033:anatomy & histology / Q000187:drug effects / Q000503:physiopathology*; D009435:Synaptic Transmission / Q000187:drug effects
D004791:Enzyme Inhibitors; D020030:Nitric Oxide Donors; D009599:Nitroprusside; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester