title: Prognostic value of serum CA-125 measurements on stimulation day 1 and on the day of oocyte pickup in the prediction of IVF treatment outcome.
abstract: OBJECTIVE
  To assess whether serum levels of CA-125, a proposed marker of endometrial receptivity, are associated with pregnancy after IVF.
  
  
  METHODS
  42 IVF pregnancies were matched with nonpregnant controls. Twenty-eight additional unmatched pregnancies were included for the comparison of pregnancy outcomes. CA-125 concentrations were measured on stimulation day 1 (SD1) and at oocyte pickup (OPU). We analyzed association between CA-125 levels and establishment of pregnancy and its outcome; correlation between CA-125 concentrations and other parameters; differences in CA-125 levels between SD1 and OPU.
  
  
  RESULTS
  In pregnant, but not in nonpregnant patients, CA-125 levels decreased significantly from SD1 to OPU. There was no significant difference in CA-125 levels at either time point between pregnant and nonpregnant subjects. No significant correlation was found between CA-125 levels and any other clinical or laboratory parameters.
  
  
  CONCLUSIONS
  CA-125 measurements at the beginning of stimulation or at oocyte retrieval are not useful in predicting IVF outcome.
authors: First Department of Obstetrics and Gynecology, Semmelweis University, Faculty of Medicine, Budapest, Hungary. humanic@noi1.sote.hu
authors: Erik E
authors: EE
authors: Hauzman
authors: Ana R
authors: AR
authors: Lagarde
authors: Katalin
authors: K
authors: Nagy
authors: Péter
authors: P
authors: Fancsovits
authors: Akos
authors: A
authors: Murber
authors: Gyözö
authors: G
authors: Jánoki
authors: Zoltán
authors: Z
authors: Papp
authors: János
authors: J
authors: Urbancsek
mesh_terms: D000328:Adult; D018394:CA-125 Antigen / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D009865:Oocytes / Q000502:physiology; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome; D011379:Prognosis; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome
chemical_list: D018394:CA-125 Antigen