Synthesis and in vitro cholesterol dissolution by 23- and 24-phosphonobile acids.
A new class of 23- and 24-phosphonobile acids have been synthesized from bile acid and their in vitro cholesterol-dissolving efficiency have been estimated. 24-Phosphonobile salts (PBSs) are slightly more efficient in solubilizing cholesterol than 23-PBSs and natural bile salts. The cholesterol solubilizing power is influenced by the structure of PBSs, and is considerably reduced with an increase in the bulk pH.
Babu
Ponnusamy
P
Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, India.
Maitra
Uday
U
D001647:Bile Acids and Salts / Q000138:chemical synthesis* / Q000494:pharmacology; D002784:Cholesterol / Q000378:metabolism*; D007700:Kinetics; D008823:Micelles; D008968:Molecular Conformation; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000494:pharmacology; D012995:Solubility; D013329:Structure-Activity Relationship; D013499:Surface Properties
D001647:Bile Acids and Salts; D008823:Micelles; D063065:Organophosphonates; D002784:Cholesterol