Arrhythmogenic effect of epinephrine during correction of dyslipidemia.
In rats with dyslipidemia epinephrine decreased HR and suppressed automaticity of the sinus node. This effect was not eliminated by LBK-149, dibunol, and glutabiance despite normalization of the plasma lipid spectrum. LBK-149 prevented the development of heart rhythm disturbances during epinephrine administration.
Artem'eva
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OV
Mordvinian State University, Saransk. olgart69@mail.ru
Zor'kina
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AV
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000503:physiopathology; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D002784:Cholesterol; D004562:Electrocardiography; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006949:Hyperlipidemias / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D051381:Rats; D012849:Sinoatrial Node / Q000187:drug effects; D014807:Vitamin D
D000889:Anti-Arrhythmia Agents; D014807:Vitamin D; D002084:Butylated Hydroxytoluene; D002784:Cholesterol; D004837:Epinephrine