Subtyping obsessive-compulsive disorder: clinical and immunological findings in child and adult onset.
It has been suggested that certain kinds of childhood OCD with specific clinical, biological and immunological characteristics may form a subgroup of OCD. We study the presence of these characteristics in child onset OCD and propose that the disorder be considered as a subtype of adult OCD. Forty adult patients with OCD were divided in two groups according to time of disease onset: 18 early onset and 21 late. Both sets were compared with a control group of 14 psychiatric patients. Child onset OCD was associated with higher mean ASLO titers, higher frequencies of history of tic disorders and tonsillitis in childhood and compulsive symptoms. No differences were found in D8/17 antibody titers or in other autoimmune parameters. The findings suggest that child onset OCD can be considered as a subgroup of adult OCD, although more specific biological markers are needed to identify it.
Morer
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Department of Child and Adolescent Psychiatry and Psychology, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Hospital Clínic Universitari, Sabino Arana no. 1, 08028 Barcelona, Spain. amorer@clinic.ub.es
Viñas
O
O
Lázaro
L
L
Calvo
R
R
Andrés
S
S
Bosch
J
J
Gastó
C
C
Massana
J
J
Castro
J
J
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000911:Antibodies, Monoclonal / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology; D016827:CD8 Antigens / Q000276:immunology*; D002648:Child; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000145:classification / Q000276:immunology / Q000523:psychology
D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D016827:CD8 Antigens; D007075:Immunoglobulin M