Peptidoglycan and bacterial DNA induce inflammation and coagulation markers in synergy.
Bacterial compounds signal the presence of foreign pathogens in the innate immune system. These microbial components are key players in infectious diseases and implicate toll-like receptors in the activation of inflammation and coagulation. Nevertheless, the existence of a synergistic relationship between peptidoglycan and bacterial DNA on these two physiological responses has not been investigated. The present study reports new findings on the regulation of tumor necrosis factor alpha and tissue factor in peripheral blood mononuclear cells by peptidoglycan and bacterial DNA. These were found to induce tumor necrosis factor alpha and tissue factor simultaneously and in a synergistic manner. These findings provide a new proinflammatory and procoagulant mechanism likely to play a role in sepsis pathogenesis.
Amoureux
Marie-Claude
MC
Clarigen Inc, Carlsbad, CA 92008, USA. mcamoureux@earthlink.net
Rajapakse
Nandani
N
Stipkovits
Lazlo
L
Szathmary
Susan
S
D015415:Biomarkers; D001777:Blood Coagulation / Q000187:drug effects*; D004269:DNA, Bacterial / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006801:Humans; D007249:Inflammation / Q000139:chemically induced*; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D009000:Monocytes / Q000378:metabolism; D010457:Peptidoglycan / Q000494:pharmacology*; D013925:Thromboplastin / Q000096:biosynthesis*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D015415:Biomarkers; D004269:DNA, Bacterial; D010457:Peptidoglycan; D014409:Tumor Necrosis Factor-alpha; D013925:Thromboplastin