Cell adhesion: sorting out cell mixing with echinoid?
Cadherins control intercellular adhesion in epithelial cells. This property relies on the ability to recruit actin filaments at adherens junctions via beta-catenin and alpha-catenin. A recent study shows that Echinoid, a member of the immunoglobulin domain containing protein family, is a modulator of intercellular adhesion in Drosophila that controls cell sorting.
Lecuit
Thomas
T
Laboratoire de Génétique et de Physiologie du Développement, UMR 6545, CNRS-Université de la Méditerrannée, Institut de Biologie du Développement de Marseille, France. lecuit@ibdm.univ-mrs.fr
D022005:Adherens Junctions / Q000378:metabolism*; D000818:Animals; D015820:Cadherins / Q000378:metabolism; D002448:Cell Adhesion / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000378:metabolism* / Q000502:physiology; D004330:Drosophila / Q000502:physiology*; D029721:Drosophila Proteins / Q000378:metabolism* / Q000502:physiology; D004847:Epithelial Cells / Q000502:physiology*; D008954:Models, Biological; D012097:Repressor Proteins / Q000378:metabolism* / Q000502:physiology
D015820:Cadherins; D015815:Cell Adhesion Molecules; D029721:Drosophila Proteins; C422623:ED protein, Drosophila; D012097:Repressor Proteins