Effect of NO synthesis blocker on electrical activity of rat stomach and small intestine in the early postoperation period.
The effect of NO on electrical activity of the stomach and small intestine was studied in chronic experiments on rats during the early postoperation period. Generation of migrating myoelectric complex in the stomach and small intestine was impaired after abdominal surgery. Administration of NO synthesis blocker suppressed the inhibitory influences, which potentiated generation of the myoelectric complex in the small intestine. Our results suggest that NO is involved in the regulation of the migrating myoelectric complex in the small intestine during postoperation motor disturbances in the gastrointestinal tract.
Tropskaya
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NS
N. V. Sklifosovsky Institute of Emergency Medicine, Moscow. ntropskaya@mail.ru
Popova
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Solov'eva
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GI
D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D004386:Duodenum / Q000187:drug effects / Q000294:innervation / Q000502:physiology; D004576:Electromyography / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D007421:Intestine, Small / Q000187:drug effects* / Q000294:innervation / Q000502:physiology; D007583:Jejunum / Q000187:drug effects / Q000294:innervation / Q000502:physiology; D008297:Male; D016065:Myoelectric Complex, Migrating / Q000187:drug effects / Q000502:physiology; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D011184:Postoperative Period; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000187:drug effects* / Q000294:innervation / Q000502:physiology / Q000601:surgery; D013997:Time Factors
D004791:Enzyme Inhibitors; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester