Effects of visible light irradiation on eugenol-treated oral mucosa.
The purpose of this study was to evaluate the histopathological effects of eugenol (EUG) and iso-eugenol (IsoEUG)--with or without visible light (VL) irradiation--on oral mucous membranes. Oral mucous membranes of mice were applied with three agents, EUG, IsoEUG, and aceton (as the control) in the absence or presence of VL irradiation. VL irradiation resulted in more tissue damage for EUG- or IsoEUG-treated mucosa compared to corresponding compounds without VL irradiation, and that damage under IsoEUG treatment was greater than that under EUG treatment. Necrosis, but not apoptosis, was preferentially expressed in EUG- or IsoEUG-treated mucous membranes in the presence of VL irradiation.
Fujisawa
Seiichiro
S
Department of Oral Diagnosis, School of Dentistry, Meikai University, Keyakidai, Sakado, Saitama 350-0283, Japan. fujisawa@dent.meikai.ac.jp
Muraoka
Eitoku
E
Nakazato
Yoshihiro
Y
Okada
Norihisa
N
D000818:Animals; D005054:Eugenol / Q000031:analogs & derivatives / Q000633:toxicity*; D020287:In Situ Nick-End Labeling; D008027:Light / Q000009:adverse effects*; D051379:Mice; D008813:Mice, Inbred ICR; D009061:Mouth Mucosa / Q000187:drug effects* / Q000528:radiation effects*; D009336:Necrosis
D005054:Eugenol; C036643:isoeugenol