title: Accumulation of Tc99m-DMSA-3 in the spleen in a case of multiple myeloma with associated amyloidosis.
abstract: We describe a case of a 58-year-old male with longstanding hypertension and Type 2 diabetes mellitus who developed sudden onset renal impairment. The first clue to the possible presence of amyloidosis in this case was provided by the radionuclide renal cortical scan performed with trivalent dimercapto succinic acid (Tc99m-DMSA-3), which revealed intense tracer uptake in the spleen suggesting amyloid deposit. Further workup to ascertain the cause of amyloidosis led to the diagnosis of multiple myeloma. We conclude that in cases of extra-renal or splenic accumulation of Tc99m-DMSA-3, a diagnosis of amyloidosis should be considered, in an appropriate clinical setting.
authors: Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India. danzig@rediffmail.com
authors: S
authors: S
authors: Barai
authors: G P
authors: GP
authors: Bandopadhayaya
authors: M
authors: M
authors: Rathi
authors: N G
authors: NG
authors: Singh
mesh_terms: D000686:Amyloidosis / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis*; D019275:Radiopharmaceuticals; D013158:Splenic Diseases / Q000175:diagnosis*; D019783:Technetium Tc 99m Dimercaptosuccinic Acid
chemical_list: D019275:Radiopharmaceuticals; D019783:Technetium Tc 99m Dimercaptosuccinic Acid