title: Spontaneous chronic subdural hematomas in young adults with a deficiency in coagulation factor XIII. Report of three cases.
abstract: Chronic subdural hematomas (SDHs) generally occur in elderly patients. Its pathogenesis is usually related to head trauma with tearing and rupture of the bridging veins, although in some cases a history of trauma is not recognizable. There are many reports regarding the association between spontaneous chronic SDHs and an alteration in coagulative parameters. A coagulative disorder should be suspected when an unexplained hemorrhage occurs, especially in a young patient. The authors report on three young men with a deficiency in coagulation factor XIII (FXIII) who underwent surgery for chronic SDHs. The role of FXIII in the pathogenesis of chronic SDH is emphasized. In patients with unexplained chronic SDH all coagulation parameters and factors should be screened to identify an eventual coagulative disorder.
authors: Department of Neurosurgery, Catholic University, Rome, Italy.
authors: Alessio
authors: A
authors: Albanese
authors: Antonio
authors: A
authors: Tuttolomondo
authors: Carmelo
authors: C
authors: Anile
authors: Giovanni
authors: G
authors: Sabatino
authors: Angelo
authors: A
authors: Pompucci
authors: Antonio
authors: A
authors: Pinto
authors: Guiseppe
authors: G
authors: Licata
authors: Annunziato
authors: A
authors: Mangiola
mesh_terms: D000328:Adult; D005176:Factor XIII / Q000008:administration & dosage; D005177:Factor XIII Deficiency / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006261:Headache / Q000209:etiology / Q000473:pathology / Q000601:surgery; D020200:Hematoma, Subdural, Chronic / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011182:Postoperative Care
chemical_list: D005176:Factor XIII