title: Lack of association with the CD28/CTLA4/ICOS gene region among Norwegian multiple sclerosis patients.
abstract: Chromosome region 2q33 encodes several regulators of the immune system, among these the CD28, CTLA4, and ICOS molecules. Involvement of these genes in multiple sclerosis (MS) is not yet clear. We investigated six microsatellites and three SNPs in a relatively large and clinically well characterised Norwegian MS cohort. No associations were observed for any of the markers analysed in 575 MS patients and 551 controls. Associations were neither found when stratifying the material for the HLA-DRB1*1501, DQB1*0602 haplotype, gender, age at onset, disease course nor familial aggregation. In conclusion, this study could not confirm association with the CD28/CTLA4/ICOS gene region.
authors: Institute of Immunology, University of Oslo and Rikshospitalet University Hospital, 00207 Oslo, Norway. a.r.lorentzen@studmed.uio.no
authors: Aslaug R
authors: AR
authors: Lorentzen
authors: Elisabeth G
authors: EG
authors: Celius
authors: Per O
authors: PO
authors: Ekstrøm
authors: Kristine
authors: K
authors: Wiencke
authors: Benedicte A
authors: BA
authors: Lie
authors: Kjell-Morten
authors: KM
authors: Myhr
authors: Vincent
authors: V
authors: Ling
authors: Erik
authors: E
authors: Thorsby
authors: Frode
authors: F
authors: Vartdal
authors: Anne
authors: A
authors: Spurkland
authors: Hanne F
authors: HF
authors: Harbo
mesh_terms: D000293:Adolescent; D000328:Adult; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000235:genetics*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics*; D018106:CD28 Antigens / Q000235:genetics*; D060908:CTLA-4 Antigen; D016022:Case-Control Studies; D002648:Child; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D006801:Humans; D060889:Inducible T-Cell Co-Stimulator Protein; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics; D018895:Microsatellite Repeats; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology*; D009664:Norway; D020641:Polymorphism, Single Nucleotide
chemical_list: D015703:Antigens, CD; D000943:Antigens, Differentiation; D000945:Antigens, Differentiation, T-Lymphocyte; D018106:CD28 Antigens; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C489631:HLA-DRB1*15:01 antigen; C556692:ICOS protein, human; D060889:Inducible T-Cell Co-Stimulator Protein; D008562:Membrane Glycoproteins