Localization of intracellular and plasma membrane Ca2+-ATPases in the cerebellum.
The sarco-endoplasmic reticulum Ca2+-ATPase and the plasma membrane Ca2+-ATPase contribute to the regulation of the intracellular Ca2+ concentration. These proteins transport Ca2+ ions into the endoplasmic reticulum and to the extracellular medium, respectively. A different localization of the two families of Ca2+-ATPases has been shown in concrete subcellular areas of Purkinje cells and in other neuronal elements from cerebellum. In the light of the actual knowledge of Ca2+-ATPases, this strict distribution suggests the existence of different demands on Ca2+ homeostasis in these cerebellar and cellular subregions.
Sepúlveda
M Rosario
MR
Departamento de Bioquímica y Biologia Moleculary Genética, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Spain.
Mata
Ana M
AM
D000818:Animals; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D002462:Cell Membrane / Q000201:enzymology*; D002531:Cerebellum / Q000166:cytology / Q000201:enzymology*; D005110:Extracellular Space / Q000201:enzymology*; D009474:Neurons / Q000648:ultrastructure*
D000252:Calcium-Transporting ATPases