High-resolution magic angle spinning NMR of the neuronal tau protein integrated in Alzheimer's-like paired helical fragments.
HRMAS NMR of tau paired helical fragments assembled with heparin show an intensity decrease for those amino acids that are incorporated into the rigid core region, whereas the N-terminal amino acids maintain their full mobility.
Sillen
Alain
A
CNRS - Université de Lille 2 UMR 8525 and Inserm IFR17, Institut Pasteur de Lille, BP 245 - F-59019 Lille Cedex, France.
Wieruszeski
Jean-Michel
JM
Leroy
Arnaud
A
Younes
Amena Ben
AB
Landrieu
Isabelle
I
Lippens
Guy
G
D000544:Alzheimer Disease / Q000378:metabolism; D007382:Intermediate Filaments / Q000737:chemistry* / Q000378:metabolism; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D016875:tau Proteins / Q000737:chemistry* / Q000378:metabolism
D016875:tau Proteins