[Research of markers for the genes of the heavy chain of cardiac beta-myosin and myosin binding protein C in relatives of patients with hypertrophic cardiomyopathy].
OBJECTIVE
To study the molecular markers for the genes of the heavy chain of cardiac beta-myosin and the myosin binding protein C in relatives of carriers of hypertrophic cardiomyopathy.


METHODS
Twelve families who had anamnesis, physical exam, electrocardiogram, echocardiogram and blood collection for the genetic study through the chain reaction of polymerase.


RESULTS
From the 227 relatives, 25% were ill-taken, with 51% men, with an average age of 35+/-19 (2 to 95) years old. The genetic analysis showed a connection with the gene of the cardiac b-myosin in a family and, in another, a connection with the gene of the myosin-binding protein C. In five families, the connections with the two genes were excluded; in two, the connection with the gene of the myosin-binding protein C, but for the b-myosin gene the results were non-conclusive; in two families, the results were non-conclusive for both genes and in one the connection for the b-myosin gene was excluded. The results were non-conclusive for the gene of the myosin-binding protein C.


CONCLUSIONS
In our environment, other genes, different from those described in the literature, may prevail, or there are other genetic differences related to the origin of our population and/or environmental factors.
Tirone
Adriana Paula
AP
Instituto do Coração do Hospital das Clínicas, FMUSP, São Paulo, Brazil.
Arteaga
Edmundo
E
Pereira
Alexandre da Costa
Ada C
Krieger
José Eduardo
JE
Buck
Paula de Cássia
Pde C
Ianni
Barbara Maria
BM
Mady
Charles
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D024741:Cardiomyopathy, Hypertrophic, Familial / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D018995:Myosin Heavy Chains / Q000235:genetics*; D010375:Pedigree; D010641:Phenotype; D024723:Ventricular Myosins / Q000235:genetics*; D000099163:Myosin Binding Protein C
D002352:Carrier Proteins; D005819:Genetic Markers; D018995:Myosin Heavy Chains; D024723:Ventricular Myosins; D000099163:Myosin Binding Protein C