title: Mouse mutants as models for congenital retinal disorders.
abstract: Animal models provide a valuable tool for investigating the genetic basis and the pathophysiology of human diseases, and to evaluate therapeutic treatments. To study congenital retinal disorders, mouse mutants have become the most important model organism. Here we review some mouse models, which are related to hereditary disorders (mostly congenital) including retinitis pigmentosa, Leber's congenital amaurosis, macular disorders and optic atrophy.
authors: GSF-National Research Center for Environment and Health, Institute of Developmental Genetics, D-85764 Neuherberg, Germany. dalke@gsf.de
authors: Claudia
authors: C
authors: Dalke
authors: Jochen
authors: J
authors: Graw
mesh_terms: D000818:Animals; D015870:Gene Expression; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008817:Mice, Mutant Strains; D023421:Models, Animal; D012160:Retina / Q000378:metabolism; D012164:Retinal Diseases / Q000151:congenital* / Q000378:metabolism