title: Prevalence of allergic fungal sinusitis in refractory chronic rhinosinusitis in adult Malaysians.
abstract: OBJECTIVE
  To determine the prevalence of allergic fungal sinusitis (AFS) in refractory chronic rhinosinusitis (CRS) in adult Malaysians.
  
  
  METHODS
  This cross-sectional study involved 30 immunocompetent CRS patients who underwent surgery. Specimens were sent for mycology and histopathologic analysis for identification of fungi. Clinical and immunological workup was performed for atopy in all patients and controls.
  
  
  RESULTS
  Fungal cultures were positive in 5 (16.7%) and 11 (36.7%) of 30 patients from nasal secretions and surgical specimens, respectively. Allergic mucin was found in 8 surgical specimens (26.7%). Hence, prevalence of AFS was 26.7%. The most common causative agent was Aspergillus sp. (54.5%). In 3 (37.5%) of 8 patients, AFS was found to be associated with asthma. Twenty-five percent (2/8 patients) had aspirin intolerance, and 62.5% (5/8 patients) had elevated total immunoglobulin E levels. All patients had positive skin test reactivity to fungal allergen.
  
  
  CONCLUSIONS
  This preliminary study suggests that AFS does exist in Malaysia. Proper handling of surgical specimens and accurate diagnosis by the pathologist and mycologist are essential.
authors: Department of Otorhinolaryngology, Faculty of Medicine, National University of Malaysia, Kuala Lumpur.
authors: Bee-See
authors: BS
authors: Goh
authors: Balwant Singh
authors: BS
authors: Gendeh
authors: Isa Mohamed
authors: IM
authors: Rose
authors: Sabiha
authors: S
authors: Pit
authors: Shamim Abdul
authors: SA
authors: Samad
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D006801:Humans; D008296:Malaysia / Q000453:epidemiology; D009181:Mycoses / Q000150:complications*; D009296:Nasal Cavity; D015995:Prevalence; D012130:Respiratory Hypersensitivity / Q000453:epidemiology* / Q000382:microbiology* / Q000473:pathology; D012220:Rhinitis / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology; D012852:Sinusitis / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology; D007507:Therapeutic Irrigation