title: Granulocytic sarcoma of the heart: extramedullary relapse of acute myeloblastic leukemia after allogeneic stem cell transplantation successfully treated by chemotherapy alone.
abstract: We present a case of granulocytic sarcoma (GS) of the heart. A 28-year-old man with relapsed acute myelogenous leukemia (AML-M2) had undergone a non-myeloablative allogeneic peripheral stem cell transplantation. Three years following transplantation, masses were evidenced in his heart by echocardiography but had completely disappeared following a common chemotherapy etoposide, mitoxantrone, ara-C (EMA) regimen for relapsed AML. The involvement of the heart with GS is very rare and this is the first case of extramedullary disease in the heart after allogeneic transplantation. Here we present the case history and related literature has been reviewed.
authors: Department of Medical Oncology, Cukurova University Faculty of Medicine, Yuregir, Adana, Turkey. iokara@cu.edu.tr
authors: Ismail Oguz
authors: IO
authors: Kara
authors: Berksoy
authors: B
authors: Sahin
authors: Semra
authors: S
authors: Paydas
authors: Banu
authors: B
authors: Kara
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003561:Cytarabine / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D006338:Heart Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000628:therapy*; D008297:Male; D008942:Mitoxantrone / Q000008:administration & dosage; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D012074:Remission Induction; D023981:Sarcoma, Myeloid / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D014184:Transplantation, Homologous
chemical_list: D003561:Cytarabine; D005047:Etoposide; D008942:Mitoxantrone