[Effects of HCMV on phenotypes of parotid duct epithelial cells and its mechanisms].
OBJECTIVE
To investigate the effects of HCMV infection on phenotypes of parotid duct epithelial cells and relative mechanisms.


METHODS
The expressions of immediate early antigen of HCMV, pan cytokeratin and cathepsin D etc. were detected by immunohistochemical staining in tissues of parotid cytomegalic inclusion disease.


RESULTS
Cytokeratin which acts as an epithelial marker became negative while staining of Cathepsin D was intensified in parotid duct epithelial cells after infected by HCMV.


CONCLUSIONS
It demonstrated that cytokeratin was lost through over-expression of Cathepsin D in parotid duct epithelial cells infected by HCMV.
Yang
Guo-rong
GR
Hematology Department, Lanzhou General Hospital, Lanzhou 730050, China.
Huang
Gao-sheng
GS
Bai
Hai
H
Wang
En-hua
EH
Song
Ji-ye
JY
Guo
Ying
Y
Wang
Juan-hong
JH
Liang
Rong
R
Wang
Zhe
Z
D000818:Animals; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D002402:Cathepsin D / Q000032:analysis; D003587:Cytomegalovirus / Q000276:immunology / Q000502:physiology*; D003586:Cytomegalovirus Infections / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D003893:Desmin / Q000032:analysis; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D054884:Host-Pathogen Interactions; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007633:Keratins / Q000032:analysis; D008297:Male; D051379:Mice; D018987:Salivary Ducts / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D014746:Vimentin / Q000032:analysis; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D000956:Antigens, Viral; D002402:Cathepsin D; D003893:Desmin; D005904:Glial Fibrillary Acidic Protein; D007633:Keratins; D014746:Vimentin; C067980:CD68 antigen, human; D000097382:CD68 Molecule