[The insuline receptor: structure and function].
About 35 years after the first in vitro studies of the insulin receptor, considerable progress has been accomplished in the structural biology of the insulin-receptor interaction, and of the receptor tyrosine kinase family in general. This brief review attempts to assemble the various pieces of the puzzle, despite the lack of a detailed crystallographic structure of the insulin-receptor complex, and to establish a model that explains the mechanism of receptor activation, its negative cooperativity, and the triggering of intracellular signalling pathways.
De Meyts
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Receptor Systems Biology Laboratory, Hagedorn Research Institute, 2820 Gentofte, Danemark. pdm@novonordisk.com
D003461:Crystallography; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology*; D011972:Receptor, Insulin / Q000737:chemistry* / Q000502:physiology*; D015398:Signal Transduction; D013329:Structure-Activity Relationship
D007004:Hypoglycemic Agents; D007328:Insulin; D011972:Receptor, Insulin