title: Immune processes in periodontal disease: a review.
abstract: The inflammatory and immune processes in periodontitis are complex and, although a great deal of information is available, many questions remain. Variation in human susceptibility to periodontitis has long been accepted, but the pathological basis of this is poorly understood. Similarly, we know little of the differences, if any, between the pathology of chronic and aggressive periodontitis. Genetics and environmental influences play a role in the susceptibility process, but if and how that translates through the immune and inflammatory processes to produce the plasma cell-dominated lesions seen in periodontitis remain to be elucidated. This review will focus on immunological aspects of the inflammatory changes seen in gingivitis and periodontitis, addressing both humoral and cellular responses to the microbial insult from dental plaque. A tendency for an individual or site to form an extensive plasma cell infiltrate may indicate an inability to defend against periodontopathogens and thus a predisposition to periodontitis. The issues to be considered include: 1) homing of immune and inflammatory cells to target tissues; 2) their local proliferation and synthetic activity; 3) the cytokine profile of the leukocytes; 4) the immunoglobulin subclasses of locally produced antibodies; 5) mucosal and systemic immune characteristics of the response; 6) the humoral immune response in periodontal health and disease states; and 7) the antigenic target of the immune response in periodontal lesions.
authors: University of Glasgow Dental School, Glasgow, Scotland, United Kingdom.
authors: Denis F
authors: DF
authors: Kinane
authors: David F
authors: DF
authors: Lappin
mesh_terms: D049109:Cell Proliferation; D016207:Cytokines / Q000096:biosynthesis; D020022:Genetic Predisposition to Disease; D005891:Gingivitis / Q000276:immunology*; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000276:immunology; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D010518:Periodontitis / Q000276:immunology*; D016201:Receptors, Lymphocyte Homing
chemical_list: D016207:Cytokines; D007132:Immunoglobulin Isotypes; D016201:Receptors, Lymphocyte Homing