METHOX: a new pyridine N-oxide organocatalyst for the asymmetric allylation of aldehydes with allyltrichlorosilanes.
[reaction: see text]. Allylation of aromatic aldehydes with allyltrichlorosilane is catalyzed by the new terpene-derived pyridine N-oxide (+)-METHOX (< or =5 mol %) in MeCN with high enantioselectivities (< or =96% ee) and conversion rates; this catalyst retains high selectivity even at room temperature.
Malkov
Andrei V
AV
Department of Chemistry, Joseph Black Building, WestChem, University of Glasgow, Scotland, UK. amalkov@chem.gla.ac.uk
Bell
Mark
M
Castelluzzo
Fabiomassimo
F
Kocovský
Pavel
P