title: Methodological considerations and approach to cross-technique comparisons using in vivo coronary plaque characterization based on intravascular ultrasound radiofrequency data analysis: insights from the Integrated Biomarker and Imaging Study (IBIS).
abstract: Grey scale intravascular ultrasound (IVUS) is a valuable clinical tool to assess the extent and severity of coronary atheroma. However, it cannot reliably identify plaques with a high-risk of future clinical events. Serial IVUS studies to assess the progression and/or regression of atherosclerotic plaques demonstrated only modest effects, of pharmacological intervention on plaque burden, even when clinical efficacy is documented. Spectral analysis of radiofrequency ultrasound data (IVUS-virtual histology (IVUS-VH), Volcano Therapeutics, Rancho Cordova, CA) has the potential to characterize accurately plaque composition. The Integrated Biomarker and Imaging Study (IBIS) evaluated both invasive and non-invasive imaging techniques along with the assessment of novel biomarkers to characterize sub-clinical atherosclerosis. IVUS-VH was not included at the start of the IBIS protocol. The purpose of this paper is to describe the methodology we used to obtain and analyse IVUS-VH images and the approach to cross-correlations with the other techniques.
authors: Erasmus Medical Center, Thoraxcenter, Rotterdam, The Netherlands.
authors: G A
authors: GA
authors: Rodriguez-Granillo
authors: J
authors: J
authors: Aoki
authors: A T L
authors: AT
authors: Ong
authors: M
authors: M
authors: Valgimigli
authors: C A G
authors: CA
authors: Van Mieghem
authors: E
authors: E
authors: Regar
authors: E
authors: E
authors: McFadden
authors: P
authors: P
authors: De Feyter
authors: P W
authors: PW
authors: Serruys
mesh_terms: D015415:Biomarkers / Q000032:analysis; D006328:Cardiac Catheterization; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008297:Male; D010865:Pilot Projects; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018615:Ultrasonography, Doppler, Color; D018084:Ultrasonography, Interventional / Q000379:methods*
chemical_list: D015415:Biomarkers