title: The effect of adlay oil on plasma lipids, insulin and leptin in rat.
abstract: This study was designed to investigate the effect of dietary adlay oil on plasma lipids, insulin and lipid peroxidation levels in rats. Twenty-four male Wistar rats fed diet containing adlay oil and cholesterol were studied for 4 weeks. The animals were divided into three groups: (1) 10% lard (control) group; (2) 5% lard + 5% adlay oil (5% adlay oil) group; and (3) 10% adlay oil group. Although there was no significant difference in body weight at the end of the feeding study, rats fed a diet containing adlay oil showed a significant decrease in adipose tissue weight and relative adipose weight. In addition, the rats fed the adlay oil showed significantly decreased low-density lipoprotein cholesterol (LDL-C), insulin, leptin and thiobarbituric acid reactive substance (TBARS) concentrations after 4 weeks of the feeding study. Although a significant decrease in total plasma cholesterol was observed in rats fed the 5% adlay oil diet, no significant difference was observed between the 10% adlay oil and control groups, and neither was a significant difference in liver TBARS concentration found between the dietary groups. Results from this study suggest that dietary adlay oil can reduce leptin, adipose tissue and LDL-C levels in rats.
authors: Graduate Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan, ROC.
authors: B W
authors: BW
authors: Huang
authors: M T
authors: MT
authors: Chiang
authors: H T
authors: HT
authors: Yao
authors: W
authors: W
authors: Chiang
mesh_terms: D000818:Animals; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects*; D031742:Coix; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007328:Insulin / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008517:Phytotherapy; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000737:chemistry
chemical_list: D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents; D007328:Insulin; D010938:Plant Oils; D017392:Thiobarbituric Acid Reactive Substances