title: Erdheim-Chester disease in a child presenting with multiple jaw lesions.
abstract: BACKGROUND
  Erdheim-Chester disease is a rare histiocytic disease entity related to juvenile xanthogranuloma. It is a systemic condition, usually occurs in adult, characterized by infiltration of foamy histiocytes within the bone and soft tissues.
  
  
  RESULTS
  We report a case of 13-year-old female patient who first presented with multiple osteolytic lesions of the jaws followed by bilateral symmetrical bone lesions affecting the lower extremities, as well as brain and abdominal involvement. Histological findings of the jaw lesions showed lipid-storing CD68 (+), CD1a (-) histiocytes with Touton type giant cells.
  
  
  CONCLUSIONS
  To the best of our knowledge, this is the first case of Erdheim-Chester disease with jaw bone lesions occurring as initial presenting symptom.
authors: Department of Oral Pathology and Medicine, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan.
authors: Hitoshi
authors: H
authors: Nagatsuka
authors: Phuu Pwint
authors: PP
authors: Han
authors: Koji
authors: K
authors: Taguchi
authors: Hidetsugu
authors: H
authors: Tsujigiwa
authors: Mehmet
authors: M
authors: Gunduz
authors: Joji
authors: J
authors: Fukunaga
authors: Toshio
authors: T
authors: Sugahara
authors: Junichi
authors: J
authors: Asaumi
authors: Noriyuki
authors: N
authors: Nagai
mesh_terms: D000293:Adolescent; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D001932:Brain Neoplasms / Q000175:diagnosis; D003937:Diagnosis, Differential; D031249:Erdheim-Chester Disease / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007571:Jaw Diseases / Q000175:diagnosis*; D013577:Syndrome; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule