Synthesis of fused bicyclic imidazoles by sequential van Leusen/ring-closing metathesis reactions.
[reaction: see text]. A new strategy employing the van Leusen three-component reaction and the ring-closing metathesis reaction in a sequential fashion to access fused bicyclic imidazole rings is reported. The two-step sequence generated compounds of significant molecular complexity from simple starting materials in an expedient fashion with excellent yields.
Gracias
Vijaya
V
Scaffold-Oriented Synthesis, Medicinal Chemistry Technologies, Abbott Laboratories, R4CP, AP10, Illinois 60064-6099, USA. vijaya.gracias@abbott.com
Gasiecki
Alan F
AF
Djuric
Stevan W
SW