Correlation of reactive oxygen species levels with the fertilization rate after in vitro fertilization: a qualified meta-analysis.
Our meta-analysis analyzed the relationship between levels of reactive oxygen species (ROS) and fertilization rate after in vitro fertilization (IVF), and showed a statistically significant correlation between the ROS levels and the IVF fertilization rate (estimated overall correlation -0.374 [95% CI, -0.520, -0.205]). We conclude that ROS has a statistically significant effect on the fertilization rate after IVF, and that the measurement of ROS levels in semen specimens before IVF may be useful in predicting the IVF outcome and in counseling patients.
Agarwal
Ashok
A
Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Glickman Urological Institute, Department of Obstetrics-Gynecology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA. agarwaa@ccf.org
Allamaneni
Shyam S R
SS
Nallella
Kiran P
KP
George
Amanda T
AT
Mascha
Edward
E
D016001:Confidence Intervals; D005260:Female; D005307:Fertilization in Vitro / Q000706:statistics & numerical data*; D006801:Humans; D007246:Infertility / Q000378:metabolism*; D008297:Male; D017382:Reactive Oxygen Species / Q000032:analysis / Q000378:metabolism*; D012044:Regression Analysis
D017382:Reactive Oxygen Species