title: Combination of bortezomib, thalidomide, and dexamethasone in the treatment of relapsed, refractory IgD multiple myeloma.
abstract: The use of the proteasome inhibitor bortezomib has been recently introduced into the treatment of relapsed, refractory multiple myeloma (MM). We here demonstrate a case of a patient with IgD MM who was successfully treated with a combination of bortezomib, thalidomide, and dexamethasone. Relapse of the disease occurred following tandem autologous transplantation and was refractory to a salvage therapy consisting of thalidomide, cyclophosphamide, etoposide, and dexamethasone. While the administration of thalidomide was continued, the addition of bortezomib and dexamethasone led to a complete remission after 2 cycles of therapy. The feasibility of this treatment is supported by a recently reported phase I/II trial that used a lower dose of thalidomide in combination with an equal dose of bortezomib. This is the first report of a patient with IgD MM treated accordingly, suggesting that this entity is highly sensitive to the novel therapy.
authors: Department of Hematology and Oncology, Sana Kliniken Lübeck, Lübeck, Germany. j.schmielau@sana-luebeck.de
authors: Jan
authors: J
authors: Schmielau
authors: Christian
authors: C
authors: Teschendorf
authors: Matthias
authors: M
authors: König
authors: Wolff
authors: W
authors: Schmiegel
authors: Ullrich
authors: U
authors: Graeven
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001897:Boronic Acids / Q000008:administration & dosage*; D000069286:Bortezomib; D003907:Dexamethasone / Q000008:administration & dosage*; D018572:Disease-Free Survival; D017809:Fatal Outcome; D006801:Humans; D007072:Immunoglobulin D / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D011719:Pyrazines / Q000008:administration & dosage*; D012008:Recurrence; D012074:Remission Induction / Q000379:methods; D016879:Salvage Therapy; D013792:Thalidomide / Q000008:administration & dosage*
chemical_list: D001897:Boronic Acids; D007072:Immunoglobulin D; D011719:Pyrazines; D013792:Thalidomide; D000069286:Bortezomib; D003907:Dexamethasone