Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons.
We develop a mechanistic mathematical model of the G-protein coupled signaling pathway responsible for generating current responses in frog olfactory receptor neurons. The model incorporates descriptions of ligand-receptor interaction, intracellular transduction events involving the second messenger cAMP, effector ion-channel activity, and calcium-mediated feedback steps. We parameterized the model with respect to suction pipette current recordings from single cells stimulated with multiple odor concentrations. The proposed model accurately predicts the receptor-current response of the neuron to brief and prolonged odorant exposure and is able to produce the adaptation observed under repeated or sustained stimulation.
Dougherty
Daniel P
DP
Mathematical Biosciences Institute, Ohio State University, Columbus, OH 43210, USA.
Wright
Geraldine A
GA
Yew
Alice C
AC
D000222:Adaptation, Physiological; D000818:Animals; D002118:Calcium / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism; D007473:Ion Channels / Q000502:physiology; D008954:Models, Biological; D018034:Olfactory Receptor Neurons / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D012903:Smell / Q000502:physiology*; D014714:Vertebrates / Q000502:physiology*
D007473:Ion Channels; D000242:Cyclic AMP; D019204:GTP-Binding Proteins; D002118:Calcium