Neuropsychological prediction of recovery in late-onset major depression.
OBJECTIVE
To assess antidepressant response in late-onset major depression in relation to neuropsychological domains: attention, memory and planning.


METHODS
A neuropsychological battery was administered in 30 medication-free patients with late-onset major depression, who were then included in a 12-week antidepressant treatment regimen within a 12-month follow-up period. Logistic regression was used to define a predictive model of recovery.


RESULTS
Eighteen patients were classed as remitters and seven as non-remitters. The 'indexrem' refers to the results of a logistic regression from verbal learning and planning and had a global predictive power of 84%.


CONCLUSIONS
Our study suggests that the balance between verbal learning (memory) and planning (executive function)-both related to the dorsolateral prefrontal cortex-could predicts recovery.
Marcos
Teodor
T
Clinical Psychology Department, Institut Clínic de Psiquiatría y Psicología, Hospital Clínic de Barcelona, Barcelona, Spain. tmarcos@clinic.ub.es
Portella
Maria J
MJ
Navarro
Victor
V
Gastó
Cristóbal
C
Rami
Lorena
L
Lázaro
Luisa
L
Salamero
Manel
M
D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000627:therapeutic use*; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D015283:Citalopram / Q000627:therapeutic use; D003071:Cognition; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000523:psychology / Q000628:therapy*; D004565:Electroconvulsive Therapy / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory; D009483:Neuropsychological Tests; D009661:Nortriptyline / Q000627:therapeutic use; D011237:Predictive Value of Tests; D020127:Recovery of Function / Q000502:physiology; D016896:Treatment Outcome; D014706:Verbal Learning
D000928:Antidepressive Agents; D018687:Antidepressive Agents, Second-Generation; D000929:Antidepressive Agents, Tricyclic; D015283:Citalopram; D009661:Nortriptyline