title: [The renal failure and capillary leak during the acute stage of (Dobrava) DOB and PUU (Puumala) infection].
abstract: The target organ for Puumala (PUU) and Dobrava (DOB) viruses is the kidney, but the impact on renal function seems far more important in DOB infection than in PUU infections. Aim of study was to estimate the renal failure and capillary leak during the acute stage of DOB-infection and PUU-infection. 50 patients with serological conformed diagnosis of acute hantavirus infection were included in the study. Diuresis, serum urea and creatinine were measured. Size of kidneys and presence of ascites was followed by ultrasonography. Enlargement of both kidneys were found in all (100%) patients. Ascites was present in 8/25 (32%) DOB patients; in 1/25 (4%) PUU patient and pleural effusion in four 4/25 (16%) DOB patients. The statistically significant difference in the mean urinary output was during 5th, 6th and 7th day of hospitalization (P<0,05). Serum creatinine and urea levels were at significantly higher levels for DOB than for PUU patients (P<0,05). Acute haemodialysis was needed in 7/25 (28 %) of the DOB patients. One DOB patient died. DOB virus infection is associated with a more severe kidney function disorders than PUU virus infection. Capillary leak, which caused swollen of kidney and ascites is probably the pathogenesis key factor.
authors: Institut za Mikrobiologiju, Imunologiju i Parazitologiju, Klinicki Centar Univerziteta u Sarajevu.
authors: Mirsada
authors: M
authors: Hukić
authors: Denijal
authors: D
authors: Tulumović
authors: Lejla
authors: L
authors: Calkić
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D019559:Capillary Leak Syndrome / Q000150:complications*; D005260:Female; D018778:Hantavirus Infections / Q000150:complications / Q000503:physiopathology*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D029262:Puumala virus; D051437:Renal Insufficiency / Q000150:complications*