title: Retrovirus reverse transcriptases containing a modified YXDD motif.
abstract: The YXDD motif, where X is a variable amino acid, is highly conserved among various viral RNA-dependent DNA polymerases. Mutations in the YXDD motif can abolish enzymatic activity, alter the processivity and fidelity of enzymes and decrease virus infectivity. This review provides a summary of the significant documented studies on the YXDD motif of HIV-1, simian immunodeficiency virus, feline immunodeficiency virus and murine leukaemia virus and the impact of mutation that this motif has had on viral pathogenesis and drug treatment.
authors: Laboratory of Biochemical Pharmacology and Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
authors: Prem L
authors: PL
authors: Sharma
authors: Viktoria
authors: V
authors: Nurpeisov
authors: Raymond F
authors: RF
authors: Schinazi
mesh_terms: D020816:Amino Acid Motifs; D017124:Conserved Sequence; D004351:Drug Resistance; D006801:Humans; D012194:RNA-Directed DNA Polymerase / Q000737:chemistry* / Q000235:genetics; D012190:Retroviridae / Q000201:enzymology*; D014779:Virus Replication
chemical_list: D012194:RNA-Directed DNA Polymerase