Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer.
Sigma2 (sigma2) receptor proteins are overexpressed in several tissues and tumour cell lines. Although the biomolecular mechanism of this overexpression must be elucidated, sigma2 receptor was considered a potential biomarker for monitoring solid tumour proliferation. In this study, we verified first sigma2 receptor overexpression by saturation analysis with radioligand in six human bladder cancer specimens, then if a possible correlation could be established between sigma2 overexpression and tumour tissue stage and grade. The results displayed that sigma2 receptor protein was normally expressed in human bladder and overexpressed in the case of high-grade transitional cell carcinomas. Moreover, these receptors were undetected in a low-grade squamous cell carcinoma and in a very rare form of anaplastic, large cells plasmacytoid cancer.
Colabufo
Nicola Antonio
NA
Dipartimento Farmaco-Chimico, Facoltá di Farmacia, Universitá degli Studi di Bari, via Orabona 4, 70125 Bari, Italy. colabufo@farmchim.uniba.it
Berardi
Francesco
F
Contino
Marialessandra
M
Ferorelli
Savina
S
Niso
Mauro
M
Perrone
Roberto
R
Pagliarulo
Arcangelo
A
Saponaro
Pasquale
P
Pagliarulo
Vincenzo
V
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D002295:Carcinoma, Transitional Cell / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010954:Plasmacytoma / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D011869:Radioligand Assay; D017480:Receptors, sigma / Q000032:analysis*; D001749:Urinary Bladder Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D019459:Urothelium / Q000276:immunology / Q000378:metabolism / Q000473:pathology
D019394:Ki-67 Antigen; D017480:Receptors, sigma; C106107:sigma-2 receptor