5-HT3 receptor antagonists ameliorate fatigue: so much potential, so little knowledge!
There is growing evidence that 5-HT3 receptor blockade will benefit patients with fatigue. Further research is needed to determine the mechanism underlying this widespread clinically important symptom and therapies may be derived from targeting the 5-HT system.
Barnes
N M
NM
Cellular and Molecular Neuropharmacology Research Group, Department of Pharmacology, Division of Neuroscience, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. n.m.barnes@bham.ac.uk
D000818:Animals; D001923:Brain Chemistry; D005221:Fatigue / Q000188:drug therapy*; D006801:Humans; D051381:Rats; D012702:Serotonin Antagonists / Q000032:analysis / Q000627:therapeutic use*
D012702:Serotonin Antagonists