Two sides of a cellular coin: CD4(+)CD3- cells regulate memory responses and lymph-node organization.
We propose that CD4(+)CD3(-) cells have two functions: a well-established role in organizing lymphoid tissue during development, and a newly discovered role in supporting T-cell help for B cells both during affinity maturation in germinal centres and for memory antibody responses. As CD4(+)CD3(-) cells express the HIV co-receptors CD4 and CXC-chemokine receptor 4, we think that infection of these cells by HIV, and their subsequent destruction by the host immune system, could help to explain the loss of memory antibody responses and the destruction of lymphoid architecture that occur during disease progression to AIDS.
Lane
Peter J L
PJ
Medical Research Council, Centre for Immune Regulation, Birmingham Medical School, Vincent Drive, Birmingham B15 2TT, UK. p.j.l.lane@bham.ac.uk
Gaspal
Fabrina M C
FM
Kim
Mi-Yeon
MY
D000818:Animals; D017252:CD3 Complex / Q000032:analysis; D015704:CD4 Antigens / Q000032:analysis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D006678:HIV / Q000276:immunology; D007156:Immunologic Memory; D008198:Lymph Nodes / Q000166:cytology / Q000254:growth & development* / Q000276:immunology*; D051379:Mice; D038081:Organogenesis
D017252:CD3 Complex; D015704:CD4 Antigens