title: Cardiopulmonary effects of positive end-expiratory pressure during one-lung ventilation in anesthetized dogs with a closed thoracic cavity.
abstract: OBJECTIVE
  To evaluate the effects on oxygen delivery (DO2) of 2.5 and 5 cm H2O of positive end-expiratory pressure (PEEP) applied to the dependent lung during one-lung ventilation (OLV) in anesthetized dogs with a closed thoracic cavity.
  
  
  METHODS
  7 clinically normal adult Walker Hound dogs.
  
  
  METHODS
  Dogs were anesthetized, and catheters were inserted in a dorsal pedal artery and the pulmonary artery. Dogs were positioned in right lateral recumbency, and data were collected during OLV (baseline), after application of 2.5 cm H2O of PEEP for 15 minutes during OLV, and after application of 5 cm H2O of PEEP for 15 minutes during OLV. Hemodynamic and respiratory variables were analyzed and calculations performed to obtain DO2, and values were compared among the various time points by use of an ANOVA for repeated measures.
  
  
  RESULTS
  PEEP induced a significant decrease in shunt fraction that resulted in a significant increase in arterial oxygen saturation. However, it failed to significantly affect arterial oxygen content (CaO2) or cardiac output. Thus, DO2 was not affected in healthy normoxemic dogs as a net result of the application of PEEP.
  
  
  CONCLUSIONS
  The use of PEEP during OLV in anesthetized dogs with a closed thoracic cavity did not affect DO2. Use of PEEP during OLV in dogs with a closed thoracic cavity is recommended because it does not affect cardiac output and any gain in CaO2 will be beneficial for DO2 in critically ill patients.
authors: Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1601, USA.
authors: Miriam
authors: M
authors: Riquelme
authors: Eric
authors: E
authors: Monnet
authors: Simon T
authors: ST
authors: Kudnig
authors: James S
authors: JS
authors: Gaynor
authors: Ann E
authors: AE
authors: Wagner
authors: Denise
authors: D
authors: Corliss
authors: M D
authors: MD
authors: Salman
mesh_terms: D000704:Analysis of Variance; D000771:Anesthesia, Intravenous / Q000662:veterinary*; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002245:Carbon Dioxide / Q000097:blood; D004285:Dogs / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology; D008168:Lung / Q000502:physiology*; D010100:Oxygen / Q000008:administration & dosage / Q000097:blood*; D011175:Positive-Pressure Respiration / Q000379:methods / Q000662:veterinary*; D012123:Pulmonary Ventilation / Q000502:physiology*
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen