Aromatic benzotriazole amides--synthesis and biological evaluation.
Four derivatives of benzotriazole-5-carboxylic acid were synthesized as potential UV-light dependent DNA cleaving agent. The effect of these compounds on phiX174 RF1 phage DNA and pBR322 plasmid DNA was investigated with and without UV exposure. It has been found that the two compounds exert the influence on topological forms of DNA.
Pućkowska
Anna
A
Department of Organic Chemistry, Medical University of Białystok, 2A, A. Mickiewicza Str, 15-222 Białystok, Poland. pucanka@amb.edu.pl
Bartulewicz
Danuta
D
Midura-Nowaczek
Krystyna
K
D010584:Bacteriophage phi X 174 / Q000737:chemistry; D004247:DNA / Q000737:chemistry / Q000187:drug effects* / Q000528:radiation effects; D010957:Plasmids / Q000737:chemistry; D011838:Radiation-Sensitizing Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D014466:Ultraviolet Rays
D011838:Radiation-Sensitizing Agents; D014230:Triazoles; C012771:benzotriazole; D004247:DNA