Hormone-sensitive lipase as mediator of lipolysis in contracting skeletal muscle.
The authors propose that the enzyme hormone-sensitive lipase (HSL), which is the rate-limiting enzyme for hydrolysis of triacylglycerol in adipocytes, also regulates the intramyocellular triacylglycerol mobilization and is controlled by mechanisms similar to those regulating glycogen phosphorylase. From an exercise perspective, it is fascinating that the primary enzymatic setting allows simultaneous mobilization of all major extramuscular and intramuscular energy stores.
Donsmark
Morten
M
Copenhagen Muscle Research Centre at Department of Medical Physiology, The Panum Institute, University of Copenhagen, Copenhagen, Denmark. mdonsmark@mfi.ku.dk
Langfort
Jozef
J
Holm
Cecilia
C
Ploug
Thorkil
T
Galbo
Henrik
H
D000818:Animals; D004837:Epinephrine / Q000378:metabolism; D015444:Exercise / Q000502:physiology; D006801:Humans; D008066:Lipolysis / Q000502:physiology*; D009119:Muscle Contraction / Q000502:physiology*; D018482:Muscle, Skeletal / Q000378:metabolism*; D010805:Physical Conditioning, Animal / Q000502:physiology; D051381:Rats; D002787:Sterol Esterase / Q000378:metabolism*
D002787:Sterol Esterase; D004837:Epinephrine