title: The pathophysiology of the aqueduct stroke volume in normal pressure hydrocephalus: can co-morbidity with other forms of dementia be excluded?
abstract: Variable results are obtained from the treatment of normal pressure hydrocephalus (NPH) by shunt insertion. There is a high correlation between NPH and the pathology of Alzheimer's disease (AD) on brain biopsy. There is an overlap between AD and vascular dementia (VaD), suggesting that a correlation exists between NPH and other forms of dementia. This study seeks to (1) understand the physiological factors behind, and (2) define the ability of, the aqueduct stroke volume to exclude dementia co-morbidity. Twenty-four patients from a dementia clinic were classified as having either early AD or VaD on the basis of clinical features, Hachinski score and neuropsychological testing. They were compared with 16 subjects with classical clinical findings of NPH and 12 aged-matched non-cognitively impaired subjects. MRI flow quantification was used to measure aqueduct stroke volume and arterial pulse volume. An arterio-cerebral compliance ratio was calculated from the two volumes in each patient. The aqueduct stroke volume was elevated in all three forms of dementia, with no significant difference noted between the groups. The arterial pulse volume was elevated by 24% in VaD and reduced by 35% in NPH, compared to normal (P = 0.05 and P = 0.002, respectively), and was normal in AD. There was a spectrum of relative compliance with normal compliance in VaD and reduced compliance in AD and NPH. The aqueduct stroke volume depends on the arterial pulse volume and the relative compliance between the arterial tree and brain. The aqueduct stroke volume cannot exclude significant co-morbidity in NPH.
authors: Department of Medical Imaging, John Hunter Hospital, Locked Bag 1, Newcastle Region Mail Centre, Newcastle, 2310, Australia. grant.bateman@hnehealth.nsw.gov.au
authors: Grant A
authors: GA
authors: Bateman
authors: Christopher R
authors: CR
authors: Levi
authors: Peter
authors: P
authors: Schofield
authors: Yang
authors: Y
authors: Wang
authors: Elizabeth C
authors: EC
authors: Lovett
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology*; D016022:Case-Control Studies; D002535:Cerebral Aqueduct / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D015897:Comorbidity; D015140:Dementia, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D013318:Stroke Volume