[Preparation, identification and inclusion actions of irisquinone hydroxypropyl-beta-cyclodextrin inclusion complex].
OBJECTIVE
To perpare and identify irisquinone hydroxypropyl-beta-cyclodextrin inclusion complex (irisquinone-HP-beta-CD), as well as to study the inclusion mechanism and molecule stoichiometry between irisquinone and hydroxypropyl-beta-cyclodextrin.


METHODS
Irisquinone-HP-beta-CD was prepared by freeze-drying technique. The ratio of host and guest was also studied in inclusion process by mol gradient and continuing variational methods. At the same time, the inclusion complex was identified by X-ray diffraction (XRD) and differential scanning calorimetry (DSC).


RESULTS
It was demonstrated that the solubility of irisquinone was enhanced markedly by inclusion with HP-beta-CD when stoichiometry was 2:1 of host and guest at 25 degrees C, 35 degrees C and 45 degrees C.


CONCLUSIONS
The solubility and stability of irisquinone could be increased by preparing the inclusion complex with hydroxypropyl-beta-cyclodextrin.
Zhang
Xue-nong
XN
Department of Pharmacy, Suzhou University, Suzhou 215007, China. zhangxuenong@163.com
Yan
Xue-ying
XY
Tang
Li-hua
LH
Gong
Jin-hong
JH
Zhang
Qiang
Q
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D016227:Benzoquinones / Q000008:administration & dosage* / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D004339:Drug Compounding / Q000379:methods*; D004355:Drug Stability; D005612:Freeze Drying; D012995:Solubility; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000008:administration & dosage* / Q000737:chemistry
D016227:Benzoquinones; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; C032941:irisquinone