Protective effect of potato peel powder in ameliorating oxidative stress in streptozotocin diabetic rats.
The potential of dietary potato peel (PP) powder in ameliorating oxidative stress (OS) and hyperglycemia was investigated in streptozotocin (STZ)-induced diabetic rats. In a 4-week feeding trial, incorporation of potato peel powder (5 and 10%) in the diet of diabetic rats was found to significantly reduce the plasma glucose level and also reduce drastically the polyuria of STZ diabetic rats. The total food intake was significantly reduced in the diabetic rats fed 10% PP powder compared to the control diabetic rats. However, the body weight gain over 28 days was nearly four times greater in PP powder supplemented diabetic rats (both at 5 and 10%) compared to the control diabetic rats. PP powder in the diet also decreased the elevated activities of serum transaminases (ALT and AST) and nearly normalized the hepatic MDA and GSH levels as well as the activities of specific antioxidant enzymes in liver of diabetic rats. The result of these studies clearly establishes the modulatory propensity of PP against diabetes induced alterations. Considering that potato peels are discarded as waste and not effectively utilized, these results suggest the possibility that PP waste could be effectively used as an ingredient in health and functional food to ameliorate certain disease states such as diabetes.
Singh
Nandita
N
Food Protectants & Infestation Control Department, Central Food Technological Research Institute, Mysore 570020, India.
Kamath
Vasudeva
V
Rajini
P S
PS
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology / Q000378:metabolism / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D011208:Powders; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D011198:Solanum tuberosum / Q000737:chemistry*; D013311:Streptozocin / Q000633:toxicity; D015430:Weight Gain / Q000187:drug effects
D001786:Blood Glucose; D010936:Plant Extracts; D011208:Powders; D013311:Streptozocin