[The effects of inhaled nitric oxide on pulmonary vascular resistance in patients after total cavopulmonary connection].
OBJECTIVE
To study the effects of inhaled nitric oxide (NO) on pulmonary vascular resistance in patients after total cavopulmonary connection (TCPC).


METHODS
Fifty-two patients after TCPC were evaluated, of them 24 patients were administered with inhaled nitric oxide in the early postoperative period. The cardiac index (CI) and pulmonary vascular resistance (PVR) were compared before and after inhaled NO.


RESULTS
In experimental group, after inhaled NO, partial pressure of oxygen in artery/fraction of inspired oxygen increased from 161 +/- 17 to 193 +/- 23 (t = 2.75, P < 0.01); CI from (2.86 +/- 0.24) L.min(-1).m(-2) to (3.13 +/- 0.22) L.min(-1).m(-2) (t = 2.25, P < 0.05); PVR decreased from (4.2 +/- 0.5) U/m(2) to (3.8 +/- 1.4) U/m(2) (t = 2.29, P < 0.05); central venous pressure (CVP) from (17.0 +/- 1.8) mm Hg to (15.0 +/- 1.1) mm Hg, decreased 11.7%. Compared with the control group, respirator time decreased from (86 +/- 27) h to (54 +/- 18) h (t = 2.29, P < 0.05); ICU time from (6 +/- 2) d to (4 +/- 2) d (t = 2.32, P < 0.05); But hydrothorax drainage and length of stay had no significant difference.


CONCLUSIONS
Though inhaled NO, there is no significant long-term effects in patients after TCPC, but it may play an important role in the management of low cardiac output syndrome and high cava pressure caused by reactive elevated pulmonary vascular resistance in the early postoperative period of TCPC.
Yin
Zong-tao
ZT
Department of Cardiovascular Surgery, General Hospital of Shenyang Command, Shenyang 110016, China.
Zhu
Hong-yu
HY
Zhang
Ren-fu
RF
Zhang
Nan-bin
NB
Wang
Zeng-wei
ZW
Gong
Han-dong
HD
Wang
Jun
J
Song
Heng-chang
HC
D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D001166:Arteriovenous Shunt, Surgical / Q000379:methods*; D002302:Cardiac Output / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000008:administration & dosage / Q000627:therapeutic use*; D011184:Postoperative Period; D011651:Pulmonary Artery / Q000502:physiology / Q000601:surgery*; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D014684:Venae Cavae / Q000601:surgery*
D014665:Vasodilator Agents; D009569:Nitric Oxide