Pulmonary function tests versus computed tomography in sheep with experimental emphysema.
The authors explored the relative utility of pulmonary function tests (PFTs) and computed tomography (CT) to characterize the progression of papain induced emphysema in sheep (n = 12). PFT included plethysmography (FRC(pleth)), helium dilution (FRC(He)), and expired reserve volume (ERV). Following papain, FRC(pleth) and FRC(He) were unchanged; ERV decreased hence residual volume increased significantly (RV + 270 mL, +86%, P = .02). In contrast, FRC by CT increased in 10 of 12 sheep (+264 mL +21%, P = .008). We conclude that plethysmography was insensitive to emphysema, but the effect on ERV (i.e., trapped gas volume) and FRC by CT were very similar, and in line with the morphologic changes in this animal model.
Hoffman
Andrew
A
Department of Clinical Sciences, Tufts University School of Veterinary Medicine, 200 Westboro Road, North Grafton, MA 01536, USA. andrew.hoffman@tufts.edu
Tsai
Larry
L
Mazan
Melissa
M
Bellardine
Carissa
C
Bell
Allison
A
Lutchen
Ken
K
Ingenito
Edward
E
D000818:Animals; D018450:Disease Progression; D005260:Female; D008168:Lung / Q000473:pathology / Q000503:physiopathology*; D008176:Lung Volume Measurements; D010206:Papain; D011656:Pulmonary Emphysema / Q000139:chemically induced / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D012129:Respiratory Function Tests; D012680:Sensitivity and Specificity; D012756:Sheep; D014057:Tomography, X-Ray Computed
D010206:Papain