The association between microsomal epoxide hydrolase genotypes and esophageal squamous-cell-carcinoma in Taiwan: interaction between areca chewing and smoking.
One hundred and forty-five ESCC patients and 352 controls were recruited from three hospitals in Taiwan to determine the association between esophageal squamous-cell-carcinoma (ESCC) and microsomal epoxide hydrolase (mEH) genotypes at Thy113His and His139Arg. Stratified by their exposures, the His113His genotype was a significant protective factor for ESCC in areca chewers and tobacco smokers. Stratified by His113 polymorphisms, the risk of contracting ESCC for participants with His113His who chewed areca and smoked was >50% less than for those with Thy113Thy. We suggest that the mEH His113His genotype can differentiate the association between smoking, areca chewing, and ESCC.
Lin
Ying-Chu
YC
The Graduate Institute of Dental Science, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
Wu
Deng-Chyang
DC
Lee
Jang-Ming
JM
Hsu
Hon-Ki
HK
Kao
Ein-Long
EL
Yang
Chien-Hui
CH
Wu
Ming-Tsang
MT
D000328:Adult; D001114:Areca; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000235:genetics*; D004851:Epoxide Hydrolases / Q000235:genetics*; D004938:Esophageal Neoplasms / Q000201:enzymology* / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008861:Microsomes / Q000201:enzymology*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012907:Smoking; D013624:Taiwan
D004851:Epoxide Hydrolases