title: The efficacy of hypertonic saline nasal irrigation for chronic sinonasal symptoms.
abstract: OBJECTIVE
  To assess quality of life (QOL) in patients with sinonasal symptoms in response to hypertonic saline nasal irrigation (HSNI), and to assess HSNI use patterns.
  
  
  METHODS
  The study was an uncontrolled 12-month follow-up to a randomized controlled trial (RCT) and used HSNI in a community setting. We included 54 participants with recurrent or chronic sinonasal symptoms. Forty participants had been in the intervention group of a previous study; 14 had been control participants. Primary outcome measures were the Rhinosinusitis Disability Index (RSDI), a sinus-symptom severity assessment (SIA), and the Sino-Nasal Outcomes Test (SNOT-20). Secondary outcome measures were frequency and pattern of HSNI use, side effects and satisfaction.
  
  
  RESULTS
  Among participants using HSNI in the prior RCT, RSDI scores continued to improve, from 73.2 +/- 2.6 points to 80.6 +/- 2.4 points (P < 0.001). SIA and SNOT-20 scores remained stable. Former control participants reported QOL improvement similar to that of HSNI users in the prior RCT. RSDI scores improved from 62.0 +/- 3.9 points to 79.7 +/- 3.7 points (P < 0.05), SNOT-20 scores improved from 43.5 +/- 5.7 points to 28.4 +/- 4.8 points, and SIA scores improved from 4.2 +/- 0.3 points to 2.6 +/- 0.3 points (P < 0.01). Mean HSNI use for all participants was 2.4 irrigations per week; 33% of participants used HSNI regularly, 55% when symptomatic. Side effects were minor; satisfaction was high.
  
  
  CONCLUSIONS
  Participants with chronic sinonasal symptoms reported improved QOL and frequent, satisfying use of HSNI.
  
  
  CONCLUSIONS
  HSNI is an effective adjunctive treatment of chronic sinonasal symptoms.
authors: Department of Family Medicine, University of Wisconsin Medical School-Madison, 53715, USA. david.rabago@fammed.wisc.edu
authors: David
authors: D
authors: Rabago
authors: Thomas
authors: T
authors: Pasic
authors: Aleksandra
authors: A
authors: Zgierska
authors: Marlon
authors: M
authors: Mundt
authors: Bruce
authors: B
authors: Barrett
authors: Rob
authors: R
authors: Maberry
mesh_terms: D000328:Adult; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009296:Nasal Cavity / Q000503:physiopathology; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D012220:Rhinitis / Q000628:therapy*; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use*; D012852:Sinusitis / Q000628:therapy*; D007507:Therapeutic Irrigation
chemical_list: D012462:Saline Solution, Hypertonic