Skeletal muscle lipid and its association with insulin resistance: what is the role for exercise?
Skeletal muscle lipid content has been associated with insulin resistance and type 2 diabetes. However, intramuscular triglycerides can also be a fuel source for healthy muscle during exercise. The balance between storage and use of muscle triglycerides is likely a key to the interaction between dysregulated fat and glucose metabolism by healthy and insulin resistant muscle.
Goodpaster
Bret H
BH
Division of Endocrinology and Metabolism, University of Pittsburgh Department of Medicine, Montefiore Hospital, Pittsburgh, PA 15213, USA. bgood@pitt.edu
Brown
Nicholas F
NF
D000273:Adipose Tissue / Q000378:metabolism; D001823:Body Composition; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000517:prevention & control; D015444:Exercise; D006801:Humans; D007333:Insulin Resistance; D018482:Muscle, Skeletal / Q000378:metabolism*; D014280:Triglycerides / Q000378:metabolism*
D014280:Triglycerides