title: Partial pressure of nitrogen in breathing mixtures and risk of altitude decompression sickness.
abstract: BACKGROUND
  Many aircraft oxygen systems do not deliver 100% O2. Inert gases can be present at various levels. The purpose of this study was to determine the effect of these inert gas levels on decompression sickness (DCS).
  
  
  METHODS
  Subjects were exposed for 4 h to 5486 m (18,000 ft) with zero prebreathe, using either mild (Test A) or strenuous exercise (Test B), and breathing 60%N2/40%O2. Test C used a breathing mixture of 40%N2/60%O2 at 6858 m (22,500 ft) with zero prebreathe and mild exercise. Test D investigated a breathing mixture of 2.8%N2/4.2%argon/93%O2 with 4 h exposures to 7620 m (25,000 ft), mild exercise, and 90 min of preoxygenation. The controls were from previous studies using similar conditions and 100% O2.
  
  
  RESULTS
  The DCS risk for Tests A and B and the Control for B was 7%; the Control for Test A was 0% (n.s.). Breathing the 40%N2/60%O2 mixture (Test C) resulted in 43% DCS compared with 53% DCS with 100% O2 (n.s.). When the 2.8%N2/4.2%argon/93%O2 mixture was used, the results showed 25% DCS compared with 31% DCS with 100% O2 (n.s.).
  
  
  CONCLUSIONS
  The increased nitrogen and argon levels in the breathing gas while at altitudes of 5486 m to 7620 m did not increase DCS risk. These results support the concept of using the partial pressure gradient of inert gases instead of the percentage of N2 or argon in a breathing gas mixture to determine the risk of DCS during altitude exposure.
authors: Air Force Research Laboratory, AFRL/HEPG, Brooks City-Base, San Antonio, TX 78235-5105, USA. andrew.pilmanis@brooks.af.mil
authors: Andrew A
authors: AA
authors: Pilmanis
authors: James T
authors: JT
authors: Webb
authors: Ulf I
authors: UI
authors: Balldin
mesh_terms: D000337:Aerospace Medicine; D000531:Altitude; D016022:Case-Control Studies; D003664:Decompression; D003665:Decompression Sickness / Q000139:chemically induced / Q000503:physiopathology*; D006801:Humans; D009584:Nitrogen / Q000008:administration & dosage* / Q000009:adverse effects; D010100:Oxygen / Q000008:administration & dosage*; D010313:Partial Pressure; D012119:Respiration; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D009584:Nitrogen; D010100:Oxygen