title: Early elevation of interleukin-1beta and interleukin-6 levels after bare or drug-eluting stent implantation in patients with stable angina.
abstract: BACKGROUND
  Drug-eluting stent (DES) implantation represents an important innovation in the treatment of coronary artery disease. However, inflammatory-related complications, including subacute thrombosis and in-stent restenosis, are still important limitations to percutaneous coronary intervention (PCI). The aim of this study was to compare early local release of interleukin 1beta (IL-1beta) and IL-6 proinflammatory cytokines after elective placement of either bare metal stents or DES.
  
  
  METHODS
  IL-1beta and IL-6 levels were assayed in plasma obtained from the coronary sinus both before and 20 min after stent implantation in 59 patients with stable angina, who were randomly assigned to receive bare, paclitaxel-, or sirolimus-eluting stents during elective PCI.
  
  
  RESULTS
  We found that IL-1beta and IL-6 levels were significantly increased in the coronary sinus of patients receiving either bare, paclitaxel- or sirolimus-eluting stents 20 min after stent implantation as compared with basal concentrations. The variation in the level of both cytokines was comparable among the three study groups.
  
  
  CONCLUSIONS
  A local release of proinflammatory cytokines occurs shortly after coronary stent placement, including DES, which is possibly related to plaque rupture and/or endothelium traumatism following the stenting procedure. This suggests that precocious anti-inflammatory treatment could be of benefit to further improve the PCI clinical outcome.
authors: Dipartimento di Scienze Cardiovascolari e Respiratorie, Università La Sapienza, Viale del Policlinico 155, 00161, Rome, Italy. rino.sardella@uniroma1.it
authors: Gennaro
authors: G
authors: Sardella
authors: Paola
authors: P
authors: Mariani
authors: Mariadomenica
authors: M
authors: D'Alessandro
authors: Leonardo
authors: L
authors: De Luca
authors: Marianna
authors: M
authors: Pierro
authors: Massimo
authors: M
authors: Mancone
authors: Alessandro
authors: A
authors: Porretta
authors: Daniele
authors: D
authors: Accapezzato
authors: Francesco
authors: F
authors: Fedele
authors: Marino
authors: M
authors: Paroli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000628:therapy*; D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation / Q000379:methods; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007375:Interleukin-1 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage; D020123:Sirolimus / Q000008:administration & dosage; D015607:Stents
chemical_list: D007166:Immunosuppressive Agents; D007375:Interleukin-1; D015850:Interleukin-6; D017239:Paclitaxel; D020123:Sirolimus