title: Concurrent chemoradiotherapy followed by surgery in locally advanced squamous cell carcinoma of the oesophagus: a single centre experience.
abstract: BACKGROUND
  Data on combined modality treatment for locally advanced squamous cell carcinoma of the oesophagus involving Asian patients are limited.
  
  
  METHODS
  A retrospective study of 56 consecutive patients with this condition treated with concurrent chemoradiotherapy followed by surgery in a single tertiary institution in Singapore was performed.
  
  
  RESULTS
  The median overall survival of the entire cohort was 14.1 months [95% confidence interval (CI); range, 8.6 to 19.6 months]. In patients who underwent successful oesophagectomy after chemoradiotherapy (n = 17), the median survival was 27.8 months compared to 9.8 months for those who did not have surgery (n = 39) (P = 0.046, log-rank test). The median time to first relapse for the entire cohort was 16.1 months (95% CI, 7.7 to 24.5 months). The time to first relapse was 23.9 months in the subgroup of patients with successful surgery and 12.1 months in the group which did not (P = 0.147, log-rank test). The high proportion of patients who were medically unfit for surgery or declined surgery may have conferred a selection bias.
  
  
  CONCLUSIONS
  Concurrent chemoradiotherapy followed by surgery is feasible in selected patients. The benefit of adding of surgery to chemoradiotherapy is still controversial and we await the results of randomised controlled trials comparing chemoradiotherapy with surgery versus chemoradiotherapy alone.
authors: Department of Medical Oncology, National Cancer Centre, 11 Hospital Drive, Singapore 169610.
authors: N S
authors: NS
authors: Wong
authors: K F
authors: KF
authors: Foo
authors: D
authors: D
authors: Poon
authors: S S
authors: SS
authors: Leong
authors: W K
authors: WK
authors: Wong
authors: H S
authors: HS
authors: Chan
authors: K C
authors: KC
authors: Soo
authors: S P
authors: SP
authors: Yap
authors: J
authors: J
authors: Wee
authors: Y B
authors: YB
authors: Cheung
authors: E H
authors: EH
authors: Tan
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D016629:Esophagectomy; D006801:Humans; D012189:Retrospective Studies