title: Neuropsychological prediction of recovery in late-onset major depression.
abstract: OBJECTIVE
  To assess antidepressant response in late-onset major depression in relation to neuropsychological domains: attention, memory and planning.
  
  
  METHODS
  A neuropsychological battery was administered in 30 medication-free patients with late-onset major depression, who were then included in a 12-week antidepressant treatment regimen within a 12-month follow-up period. Logistic regression was used to define a predictive model of recovery.
  
  
  RESULTS
  Eighteen patients were classed as remitters and seven as non-remitters. The 'indexrem' refers to the results of a logistic regression from verbal learning and planning and had a global predictive power of 84%.
  
  
  CONCLUSIONS
  Our study suggests that the balance between verbal learning (memory) and planning (executive function)-both related to the dorsolateral prefrontal cortex-could predicts recovery.
authors: Clinical Psychology Department, Institut Clínic de Psiquiatría y Psicología, Hospital Clínic de Barcelona, Barcelona, Spain. tmarcos@clinic.ub.es
authors: Teodor
authors: T
authors: Marcos
authors: Maria J
authors: MJ
authors: Portella
authors: Victor
authors: V
authors: Navarro
authors: Cristóbal
authors: C
authors: Gastó
authors: Lorena
authors: L
authors: Rami
authors: Luisa
authors: L
authors: Lázaro
authors: Manel
authors: M
authors: Salamero
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000627:therapeutic use*; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D015283:Citalopram / Q000627:therapeutic use; D003071:Cognition; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000523:psychology / Q000628:therapy*; D004565:Electroconvulsive Therapy / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory; D009483:Neuropsychological Tests; D009661:Nortriptyline / Q000627:therapeutic use; D011237:Predictive Value of Tests; D020127:Recovery of Function / Q000502:physiology; D016896:Treatment Outcome; D014706:Verbal Learning
chemical_list: D000928:Antidepressive Agents; D018687:Antidepressive Agents, Second-Generation; D000929:Antidepressive Agents, Tricyclic; D015283:Citalopram; D009661:Nortriptyline