Immunoepidemiologic profile of Chlamydia trachomatis infection: importance of heat-shock protein 60 and interferon- gamma.
Epidemiological, animal, and in vitro investigations suggest that Chlamydia trachomatis infection engenders acquired immunity, the basis for which is incompletely defined, especially in humans. In a prospective cohort study of women at high risk for C. trachomatis infection, we found that, at baseline and after adjustment for age and other potential confounding variables, production of interferon- gamma by peripheral-blood mononuclear cells (PBMCs) stimulated with chlamydia heat-shock protein 60 strongly correlated with protection against incident C. trachomatis infection. This investigation supports a direct role for C. trachomatis-specific immune responses in altering the risk of infection and suggests immune correlates of protection that are potentially useful in vaccine development.
Cohen
Craig R
CR
Department of Obstetrics, Gynecology, and Reproductive Science, University of California, San Francisco, San Francisco, California 94105, USA. ccohen@psg.ucsf.edu
Koochesfahani
Kasra M
KM
Meier
Amalia S
AS
Shen
Caixia
C
Karunakaran
Karuna
K
Ondondo
Beartrice
B
Kinyari
Teresa
T
Mugo
Nelly R
NR
Nguti
Rosemary
R
Brunham
Robert C
RC
D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D002582:Cervix Mucus / Q000276:immunology; D018834:Chaperonin 60 / Q000097:blood*; D002690:Chlamydia Infections / Q000453:epidemiology / Q000276:immunology*; D002692:Chlamydia trachomatis; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D007630:Kenya / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors; D011477:Sex Work
D000907:Antibodies, Bacterial; D018834:Chaperonin 60; D007371:Interferon-gamma