title: Regional body fat distribution in HIV-infected patients with lipodystrophy.
abstract: BACKGROUND
  Objective criteria for the assessment of patients with lipodystrophy syndrome in human immunodeficiency virus infection (LDHIV) have not emerged.
  
  
  METHODS
  We compared regional body fat changes in 13 men with severe LDHIV on protease inhibitor-inclusive antiretroviral therapy with 13 control HIV-infected men using anthropometry, dual-energy X-ray absorptiometry (DEXA), and whole-body magnetic resonance imaging (MRI).
  
  
  RESULTS
  LDHIV patients, compared with control subjects, had thinner gluteal, suprailiac, and triceps skinfolds (p < .01) and increased waist circumference (98 +/- 5 cm vs 86 +/- 9 cm, respectively; p = .0008). DEXA studies revealed reduced lower extremity fat (12 +/- 5% vs 22 +/- 9%; p = .0006), increased head and neck fat (18 +/- 3% vs 16 +/- 1%; p = .01), and increased proportion of total body fat in the trunk (65 +/- 7% vs 53 +/- 8%; p = .0005). MRI analysis revealed reduced thigh fat (12 +/- 5% vs 22 +/- 12%; p = .01), increased dorsocervical fat depth (47 +/- 24 mm vs 19 +/- 7 mm; p = .0009), and nearly significant increase in intra-abdominal fat (218 +/- 90 cm2 vs 157 +/- 70 cm2; p = .057). Interestingly, control subjects showed a positive relationship between intra-abdominal and dorsocervical fat (r= .57, p = .04), but the LDHIV patients showed a negative relationship (r= -.55, p = .05), suggesting a novel split phenotype among LDHIV patients of either dorsocervical or intra-abdominal fat accumulation.
  
  
  CONCLUSIONS
  We conclude that MRI provides the best tools for definition of LDHIV syndrome and reveals variable phenotypes among LDHIV patients.
authors: Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9052, USA.
authors: Warren L
authors: WL
authors: Dinges
authors: Dali
authors: D
authors: Chen
authors: Peter G
authors: PG
authors: Snell
authors: Paul T
authors: PT
authors: Weatherall
authors: Dolores M
authors: DM
authors: Peterson
authors: Abhimanyu
authors: A
authors: Garg
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods*; D000273:Adipose Tissue / Q000473:pathology*; D000328:Adult; D000886:Anthropometry / Q000379:methods*; D001823:Body Composition; D016022:Case-Control Studies; D039682:HIV-Associated Lipodystrophy Syndrome / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D012885:Skinfold Thickness