Spectral polarization imaging of human prostate cancer tissue using a near-infrared receptor-targeted contrast agent.
The Cypate-Bombesin Peptide Analogue Conjugate (Cybesin) was used as a prostate tumor receptor-targeted contrast agent. The absorption and fluorescence spectra of Cybesin were measured and shown to exist in the NIR tissue "optical window". The spectral polarization imaging of Cybesin-stained prostate cancerous and normal tissues shows that prostate cancerous tissue takes-up more Cybesin than that of prostate normal tissue, making Cybesin a potential marker of prostate cancer.
Pu
Y
Y
Department of Electrical Engineering, The City College of the City Univ. of NY, Convent Avenue at 138th Street, New York, NY 10031, USA.
Wang
W B
WB
Tang
G C
GC
Zeng
F
F
Achilefu
S
S
Vitenson
J H
JH
Sawczuk
I
I
Peters
S
S
Lombardo
J M
JM
Alfano
R R
RR
D001839:Bombesin / Q000737:chemistry; D003287:Contrast Media / Q000494:pharmacology; D006801:Humans; D008297:Male; D008956:Models, Chemical; D010455:Peptides / Q000737:chemistry; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D013050:Spectrometry, Fluorescence; D013053:Spectrophotometry; D019265:Spectroscopy, Near-Infrared / Q000295:instrumentation* / Q000379:methods*
D003287:Contrast Media; D010455:Peptides; D001839:Bombesin