title: Childhood cancer following neonatal oxygen supplementation.
abstract: OBJECTIVE
  To evaluate the relationship between neonatal oxygen supplementation (O2) and childhood cancer in the Collaborative Perinatal Project (CPP).
  
  
  METHODS
  The CPP consisted of 54,795 children born between 1959 and 1966 and followed to age 8 years. We used Cox proportional hazards modeling to examine the association between history of neonatal O2 and cancer (n = 48).
  
  
  RESULTS
  The hazard ratio (HR) for any O2 was 1.77 (95% confidence interval [CI] = 0.94 to 3.35). The HR for continuous duration of O2 was near 1 and not significant. However, the HRs were 0.69 (95% CI = 0.17 to 2.88) and 2.87 (95% CI = 1.46 to 5.66) when comparing 0 to 2 and 3 or more minutes of O2, respectively, to no O2. The latter association was weaker (HR = 2.00; 95% CI = 0.88 to 4.54) and not significant ( P = .10) when analysis was restricted to cancers diagnosed after age 1 year (n = 41).
  
  
  CONCLUSIONS
  These findings are consistent with an association between O 2 for 3 minutes or longer and cancer in childhood, and should serve as a basis for further study.
authors: Department of Pediatrics, University of Minnesota, Minneapolis, MN 54555, USA. spector@epi.umn.edu
authors: Logan G
authors: LG
authors: Spector
authors: Mark A
authors: MA
authors: Klebanoff
authors: James H
authors: JH
authors: Feusner
authors: Michael K
authors: MK
authors: Georgieff
authors: Julie A
authors: JA
authors: Ross
mesh_terms: D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology*; D010100:Oxygen / Q000008:administration & dosage / Q000009:adverse effects*; D010102:Oxygen Inhalation Therapy / Q000009:adverse effects*; D016016:Proportional Hazards Models; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
chemical_list: D010100:Oxygen