title: [Post-exposure prophylaxis following exposure to HIV: adaptation to the situation may be indicated].
abstract: A woman aged 36 injured herself on a needle that had been used to take an iliac-crest biopsy from an HIV-positive patient and a man aged 34 and a woman aged 35 had sexual contact with their HIV-positive partners during which the condom tore. They were given post-exposure prophylaxis (PEP) which was formulated using medication and virus resistance data from the HIV-positive individual. At 3 and 6 months the patients were all still HIV-negative. After occupational or non-occupational exposure to HIV, PEP is initiated if there is a reasonable risk of transmission of HIV. In The Netherlands a combination of 3 antiretroviral drugs is advised based on demonstrated antiviral effectiveness in the regular treatment of HIV-infections. Frequently a standard PEP-regimen is prescribed. If the source patient has a history of antiretroviral therapy, the virus might be resistant to standard PEP-regimens. In these cases the choice of drugs in the PEP-regimen can be individualised based on the antiretroviral medication history of the source patient and known resistance patterns of the source virus.
authors: Universitair Medisch Centrum Utrecht, Heidelberglaan 100, 3584 CX Utrecht. a.m.j.wensing@azu.nl
authors: A M J
authors: AM
authors: Wensing
authors: M M E
authors: MM
authors: Schneider
authors: C A M
authors: CA
authors: Schurink
authors: S E
authors: SE
authors: Geerlings
authors: C A B
authors: CA
authors: Boucher
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D017280:Condoms; D018562:Disease Transmission, Infectious / Q000517:prevention & control*; D004781:Environmental Exposure / Q000009:adverse effects*; D004868:Equipment Failure; D005260:Female; D006678:HIV / Q000187:drug effects / Q000254:growth & development; D015658:HIV Infections / Q000517:prevention & control* / Q000635:transmission; D006801:Humans; D008297:Male; D016602:Needlestick Injuries / Q000150:complications; D016273:Occupational Exposure
chemical_list: D019380:Anti-HIV Agents