title: Two cases of fatal necrosis of the lesser pelvis in patients treated with combined radiotherapy and hyperthermia for cervical carcinoma.
abstract: This study reports two cases of fatal necrosis of the lesser pelvis in patients with advanced cervical carcinoma, who had received combined radiotherapy and hyperthermia. The necrosis reached far from the high dose area, in one of the cases even outside the radiation portals. Both patients initially had treatment-related morbidity which responded well to surgical treatment. After a disease-free interval, a rapidly progressive necrosis developed. Necrosis to this extent after combined modality treatment has, to the authors' knowledge, not been described.
authors: Department of Radiotherapy, The Hague Medical Centre, The Netherlands. r.wiggenraad@mchaaglanden.nl
authors: R
authors: R
authors: Wiggenraad
authors: C
authors: C
authors: Koning
authors: C
authors: C
authors: Westermann
authors: C
authors: C
authors: Jansen
authors: J
authors: J
authors: van der Zee
mesh_terms: D000328:Adult; D001918:Brachytherapy; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*; D003131:Combined Modality Therapy / Q000009:adverse effects; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008875:Middle Aged; D009336:Necrosis / Q000209:etiology; D010388:Pelvis / Q000473:pathology*; D011832:Radiation Injuries / Q000209:etiology / Q000473:pathology*; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*