Cardiac valves and valvular pathology: update on function, disease, repair, and replacement.
We summarize herein selected contributions over the past several decades by pathologists and others to the diagnosis, understanding, and management of valvular heart disease, including the structural basis of valve function, the pathology/pathobiology of common naturally occurring and iatrogenic lesions, developments in valve substitution, and novel approaches to valve repair, replacement, and regeneration.
Schoen
Frederick J
FJ
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. fschoen@partners.org
D000818:Animals; D001021:Aortic Valve / Q000503:physiopathology* / Q000601:surgery; D001024:Aortic Valve Stenosis / Q000503:physiopathology / Q000601:surgery; D001672:Biocompatible Materials; D002114:Calcinosis / Q000503:physiopathology; D006349:Heart Valve Diseases / Q000209:etiology / Q000503:physiopathology* / Q000601:surgery / Q000628:therapy; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008945:Mitral Valve Prolapse / Q000503:physiopathology / Q000601:surgery; D023822:Tissue Engineering
D001672:Biocompatible Materials