[Antidepressant amides from Piper laetispicum C. DC].
OBJECTIVE
To investigate the antidepressant constituents of Piper laetispicum C. DC.


METHODS
The compounds were enriched by column chromatography on silica gel. Structural determination of the pure compounds was based on extensive analyses of modern spectroscopic methods including MS, HR-MS, UV, IR, 1D- and 2D-NMR spectra. The mouse forced swimming test was used for chasing antidepressant activity.


RESULTS
Three amides were isolated and identified as N-isobutyl-(3,4-methylendioxyphenyl)-2E, 4E, 9E-undecatrienoamide (I), N-isobutyl-9-phenyl-2E, 4E-nonadienamide (II) and N-isobutyl-7-phenyl-2E, 4E-heptadienamide (III).


CONCLUSIONS
N-Isobutyl-(3,4-methylendioxyphenyl)-2E, 4E, 9E-undecatrienoamide (I) is a new compound named as laetispicine. N-Isobutyl-9-phenyl-2E, 4E-nonadienamide (II) and N-isobutyl-7-phenyl-2E, 4E-heptadienamide (III) were isolated for the first time as natural substance.
Pan
Sheng-li
SL
School of Pharmacy, Fudan University, Shanghai 200032, China. panshengli@online.sh.cn
Xie
Jing
J
Qian
Fu-gang
FG
Wang
Jun
J
Shao
Yi-ci
YC
D000928:Antidepressive Agents / Q000737:chemistry / Q000302:isolation & purification*; D052117:Benzodioxoles / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D031701:Piper / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
D000928:Antidepressive Agents; D052117:Benzodioxoles; C512035:N-isobutyl-(3,4-methylenedioxyphenyl)-2,4,9-undecatrienoamide