Prevention of adriamycin induced heart failure by an increase in endogenous adenosine production.
Adenosine (Ado) triggers several protective mechanisms that may attenuate development of heart failure, both locally and systemically. We developed a procedure allowing sustained increase in endogenous Ado production by the combined application of Ado metabolism inhibitors and nucleotide precursors. We found that our procedure attenuate the development of heart failure induced by adriamycin.
Yuen
A H Y
AH
Heart Science Centre, Imperial College at Harefield Hospital, Harefield, Middlesex, UB9 6JH, UK.
Boscoe
M
M
Lango
R
R
Suzuki
K
K
Slominska
E M
EM
Yacoub
M H
MH
Smolenski
R T
RT
D000241:Adenosine / Q000378:metabolism*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D002851:Chromatography, High Pressure Liquid; D004317:Doxorubicin / Q000009:adverse effects* / Q000494:pharmacology; D004452:Echocardiography; D006333:Heart Failure / Q000139:chemically induced* / Q000517:prevention & control; D009711:Nucleotides / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D009711:Nucleotides; D004317:Doxorubicin; D000241:Adenosine