title: Non-nicotine pharmacotherapies for smoking cessation.
abstract: International chronic obstructive pulmonary disease guidelines recommend that smokers be strongly advised to quit, and should be offered help in doing so. The most effective smoking-cessation interventions combine behavioural support with pharmacotherapies. For smokers who do not wish to use nicotine replacement treatments, bupropion is a safe and effective non-nicotine alternative first-line treatment. Nortriptyline and clonidine have demonstrated efficacy in aiding smoking cessation, but are regarded as second-line therapies. A number of other non-nicotine treatments show promise, but more data are required before these can be recommended in assisting smokers to stop.
authors: Tobacco Dependence Research and Treatment Centre, Barts and The London, Queen Mary's School of Medicine and Dentistry, Turner Street, London E1 2AD, UK. h.mcrobbie@ctru.auckland.ac.nz
authors: H
authors: H
authors: McRobbie
authors: M
authors: M
authors: Lee
authors: Z
authors: Z
authors: Juniper
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D016642:Bupropion / Q000627:therapeutic use; D003000:Clonidine / Q000627:therapeutic use; D018765:Dopamine Uptake Inhibitors / Q000627:therapeutic use; D006801:Humans; D009661:Nortriptyline / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D012907:Smoking / Q000188:drug therapy*; D016540:Smoking Cessation / Q000379:methods*; D000074606:Smoking Prevention
chemical_list: D000316:Adrenergic alpha-Agonists; D000929:Antidepressive Agents, Tricyclic; D018765:Dopamine Uptake Inhibitors; D016642:Bupropion; D009661:Nortriptyline; D003000:Clonidine