title: Olivomycin induces tumor cell apoptosis and suppresses p53-induced transcription.
abstract: Olivomycin (DNA-binding antibiotic) in nanomolar concentrations induces apoptosis of human tumor cells and inhibits p53-dependent transcription of the reporter gene (basal and induced by antitumor drugs). Olivomycin aglycon induces no cytotoxicity and does not block transcription.
authors: Institute of Carcinogenesis, N. N. Blokhin Oncological Research Center, Russian Academy of Medical Sciences, Russia.
authors: V S
authors: VS
authors: Simonova
authors: A V
authors: AV
authors: Samusenko
authors: N A
authors: NA
authors: Filippova
authors: A N
authors: AN
authors: Tevyashova
authors: L S
authors: LS
authors: Lyniv
authors: G I
authors: GI
authors: Kulik
authors: V F
authors: VF
authors: Chekhun
authors: A A
authors: AA
authors: Shtil
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002236:Carbohydrate Conformation; D045744:Cell Line, Tumor; D006801:Humans; D008969:Molecular Sequence Data; D009848:Olivomycins / Q000737:chemistry / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000502:physiology*; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*
chemical_list: D000903:Antibiotics, Antineoplastic; D016159:Tumor Suppressor Protein p53; D009848:Olivomycins