Sweet syndrome (acute febrile neutrophilic dermatosis) associated with pulmonary coccidioidomycosis.
BACKGROUND
Sweet syndrome (acute febrile neutrophilic dermatosis) may arise in association with a variety of underlying systemic diseases. Only 1 case of coccidioidomycosis-associated Sweet syndrome has previously been reported.


METHODS
We describe 2 patients who developed Sweet syndrome during the onset of acute pulmonary coccidioidomycosis. Systemic antifungal therapy was given in both cases. Respiratory symptoms and skin lesions resolved within 5 weeks.


CONCLUSIONS
Sweet syndrome may be a presenting feature of coccidioidomycosis. Recognition of the underlying pulmonary infection is important so that inappropriate treatment with systemic corticosteroids can be avoided.
DiCaudo
David J
DJ
Department of Dermatology, Mayo Clinic, Scottsdale, AZ 85259, USA. dicaudo.david@mayo.edu
Ortiz
Karel Jill
KJ
Mengden
Stephanie J
SJ
Lim
Katherine K
KK
D000284:Administration, Oral; D000287:Administration, Topical; D000368:Aged; D001707:Biopsy, Needle; D002990:Clobetasol / Q000627:therapeutic use; D003047:Coccidioidomycosis; D004359:Drug Therapy, Combination; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008172:Lung Diseases, Fungal / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D008875:Middle Aged; D018570:Risk Assessment; D012720:Severity of Illness Index; D016463:Sweet Syndrome / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D016896:Treatment Outcome
D015725:Fluconazole; D002990:Clobetasol