An easy, efficient, and completely stereoselective synthesis of (E)-alpha,beta-unsaturated esters via sequential aldol-type/elimination reactions promoted by samarium diiodide or chromium dichloride.
(E)-Alpha,beta-unsaturated esters can be obtained with complete stereoselectivity by reaction of different aldehydes and ethyl dibromoacetate promoted by SmI(2) or CrCl(2). The transformation takes place as two sequential reactions: an aldol-type reaction and a beta-elimination reaction.
Concellón
José M
JM
Departamento de Química Orgánica e Inorgánica, Facultad de Química, Universidad de Oviedo, Julián Clavería 8, 33071 Oviedo, Spain. jmcg@fq.uniovi.es
Concellón
Carmen
C
Méjica
Carmen
C