Effects of carbachol and adenosine on neurotransmitter secretion induced by potassium chloride, ionomycin, and sucrose.
We compared the effects of adenosine and cholinergic agonist carbachol on spontaneous secretion during local application of K+, ionomycin, and sucrose increasing Ca2+ concentration in the nerve terminal. Adenosine and carbachol had no effect on Ca2+ entry, but modulated later stages of exocytosis.
Shakirzyanova
A V
AV
Kazan Institute of Biochemistry and Biophysics, Kazan Research Center of the Russian Academy of Sciences. nastyas@mail.ru
Nikol'skii
E E
EE
Giniatullin
R A
RA
D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D005089:Exocytosis / Q000187:drug effects*; D015759:Ionomycin / Q000494:pharmacology; D018482:Muscle, Skeletal / Q000166:cytology; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011189:Potassium Chloride / Q000494:pharmacology; D011895:Rana ridibunda; D013395:Sucrose / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects
D018377:Neurotransmitter Agents; D015759:Ionomycin; D013395:Sucrose; D011189:Potassium Chloride; D002217:Carbachol; D000241:Adenosine