HIV-1 dynamics at different time scales under antiretroviral therapy.
We exploit a model that considers three compartments: blood plasma (BP), lymphoid tissue-interstitial spaces (LT-IS), and follicular dendritic cells (FDC), for the HIV-1 dynamics under the application of highly active antiretroviral therapy (HAART) which allowed us to unravel distinct viral dynamics occurring in short- (2 days), middle- (21 days), and long-term (183 days) time scales. The different time scales are determined by the viral clearance rate, the ratio of productively infected CD4(+) T cells to chronically infected cells, and the dissociation rate of HIV-1 complexes from FDC. This generates a scenario in which, after an initial transient stage, the viral BP dynamics decouples and becomes governed by the lymphoid tissue (LT) dynamics; in a later stage, a new decoupling occurs in which the LT-IS dynamics is slaved to that of the FDC dynamics. We observed an initial increase in the viremia after HAART in a patient who did not receive protease inhibitors (PI). By means of the above-mentioned model we were able to highlight the relevant parameters which need to be estimated at three different time scales after HAART.
García
José A
JA
Research Department, La Salle University, Benjamin Franklin 47, Col. Hipódromo-Condesa, México, D.F. 06140, México.
Soto-Ramírez
Luis E
LE
Cocho
Germinal
G
Govezensky
Tzipe
T
José
Marco V
MV
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D003713:Dendritic Cells / Q000276:immunology; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D008297:Male; D008954:Models, Biological; D013997:Time Factors; D019562:Viral Load; D014766:Viremia
D019380:Anti-HIV Agents