[The importance of hemorheological examinations in experimental limb ischemia-reperfusion injuries].
Rheological properties of the blood are determined by several factors and if they change it may be diagnostic for many diseases. It is well-known that during ischemia and reperfusion different free-radical liberating pathways are inducted besides the local physical and metabolical changes. These processes may harm red blood cells by increasing their rigidity and impairing their deformability. In ischemia-reperfusion models measurements of erythrocyte deformability is important. Characteristic alterations were observed in both rat and dog hind limb ischemia-reperfusion with vascular clamping on femoral vessels for 1 or 3 hours. Erythrocyte deformability was significantly impaired on the postoperative 1st-3rd days. The acute limb ischemia-reperfusion experimental models seem suitable for further in vivo rheological studies.
Németh
Norbert
N
Debreceni Egyetem Orvos- és Egészségtudományi Centrum, Sebészeti Mutéttani Tanszék, Debrecen. nemeth@jaguar.unideb.hu
Lesznyák
Tamás
T
Szokoly
Miklós
M
Bráth
Endre
E
Peto
Katalin
K
Szabó
Györgyi
G
Gulyás
Adrienn
A
Kiss
Ferenc
F
Imre
Sándor
S
Furka
István
I
Mikó
Irén
I
D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D004907:Erythrocyte Deformability; D005121:Extremities / Q000098:blood supply*; D018056:Hemorheology; D051381:Rats; D015427:Reperfusion Injury / Q000503:physiopathology*; D013997:Time Factors