title: Transport properties and electroanalytical response characteristics of drotaverine ion-selective sensors.
abstract: The construction and electroanalytical response characteristics of poly(vinyl chloride) matrix ion-selective sensors (ISSs) for drotaverine hydrochloride are described. The membranes incorporate ion-association complexes of drotaverine with tetraphenylborate, picrate, tetraiodomercurate, tetraiodobismuthate, Reinecke salt, and heteropolycompounds of Keggin structure-molybdophosphoric acid, tungstophosphoric acid, molybdosiliconic acid and tungstosiliconic acid as electroactive materials for ionometric sensor controls. These ISSs have a linear response to drotaverine hydrochloride over the range 8 x 10(-6) to 5 x 10(-2) mol L(-1) with cationic slopes from 51 to 58 mV per concentration decade. These ISSs have a fast response time (up to 1 min), a low determination limit (down to 4.3 x 10(-6) mol L(-1)), good stability (3-5 weeks), and reasonable selectivity. Permeabilities and ion fluxes through a membrane were calculated for major and interfering ions. Dependences of the transport properties of the membranes on the concentrations of the ion exchanger and near-membrane solution and their electrochemical characteristics are presented. The ISSs were used for direct potentiometry and potentiometric titration (sodium tetraphenylborate) of drotaverine hydrochloride. Results with mean accuracy of 99.1+/-1.0% of nominal were obtained which corresponded well to data obtained by use of high-performance liquid chromatography.
authors: Department of Analytical Chemistry, Saint-Petersburg State Institute of Technology, Moskovsky pr. 26, Saint-Petersburg 190013, Russian Federation. kharitonov@hotmail.ru
authors: Sergey V
authors: SV
authors: Kharitonov
mesh_terms: D002138:Calibration; D004563:Electrochemistry; D017736:Ion-Selective Electrodes; D008567:Membranes, Artificial; D010208:Papaverine / Q000031:analogs & derivatives* / Q000032:analysis; D010276:Parasympatholytics / Q000032:analysis*; D010539:Permeability; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011143:Polyvinyl Chloride / Q000737:chemistry; D011199:Potentiometry; D012680:Sensitivity and Specificity; D013607:Tablets; D013997:Time Factors
chemical_list: D008567:Membranes, Artificial; D010276:Parasympatholytics; D004364:Pharmaceutical Preparations; D013607:Tablets; D011143:Polyvinyl Chloride; C005317:drotaverin; D010208:Papaverine