Application of pharmaceutical profiling assays for optimization of drug-like properties.
Pharmaceutical profiling assays provide an early assessment of drug-like properties, such as solubility, permeability, metabolism, stability and drug-drug interactions. This information can be used to alert project teams to potential property issues, predict and diagnose in vivo assay results, guide structure-property relationships, provide insight into structure modification, and help drug discovery teams to make informed decisions. Successful drugs can be developed when biological activities of interest and pharmaceutical properties are optimized in parallel.
Di
Li
L
Wyeth Inc, 865 Ridge Road, Monmouth Junction, NJ 08852, USA. dil@wyeth.com
Kerns
Edward H
EH
D000818:Animals; D002626:Chemistry, Pharmaceutical; D015195:Drug Design; D004355:Drug Stability; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010600:Pharmacology / Q000379:methods*; D013329:Structure-Activity Relationship
D004364:Pharmaceutical Preparations