Update on estimation of mutation rates using data from fluctuation experiments.
This note discusses a minor mathematical error and a problematic mathematical assumption in Luria and Delbrück's (1943) classic article on fluctuation analysis. In addition to suggesting remedial measures, the note provides information on the latest development of techniques for estimating mutation rates using data from fluctuation experiments.
Zheng
Qi
Q
Department of Epidemiology and Biostatistics, School of Rural Public Health, Texas A&M University System Health Science Center, Bryan, 77802, USA. qzheng@srph.tamhsc.edu
D003627:Data Interpretation, Statistical; D008957:Models, Genetic; D009154:Mutation / Q000235:genetics*; D012107:Research Design