title: Drug interaction between gefitinib and warfarin.
abstract: Gefitinib is a synthetic, oral anilinoquinazoline specifically designed to inhibit the epidermal growth factor receptor tyrosine kinase, and is the first targeted drug to demonstrate reproducible activity in non-small cell lung cancer patients who do not respond to platinum-based chemotherapy. In this report, we present two cases of an interaction between gefitinib and warfarin which has not been reported previously. Because of the potentially serious consequences of this interaction, close monitoring of the International Normalized Ratio and warfarin dosage adjustment are recommended for patients receiving warfarin together with gefitinib.
authors: Department of Respiratory Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-0022, Japan.
authors: Sayaka
authors: S
authors: Onoda
authors: Hisashi
authors: H
authors: Mitsufuji
authors: Nobuo
authors: N
authors: Yanase
authors: Shinichiro
authors: S
authors: Ryuge
authors: Emi
authors: E
authors: Kato
authors: Mayumi
authors: M
authors: Wada
authors: Kaori
authors: K
authors: Ishii
authors: Shintaro
authors: S
authors: Hagiri
authors: Michiko
authors: M
authors: Yamamoto
authors: Masanori
authors: M
authors: Yokoba
authors: Tomoko
authors: T
authors: Yanaihara
authors: Masaru
authors: M
authors: Kuboto
authors: Nobukazu
authors: N
authors: Takada
authors: Masato
authors: M
authors: Katagiri
authors: Tadashi
authors: T
authors: Abe
authors: Naohiko
authors: N
authors: Tanaka
authors: Hirosuke
authors: H
authors: Kobayashi
authors: Noriyuki
authors: N
authors: Masuda
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D004334:Drug Administration Schedule; D004347:Drug Interactions; D004357:Drug Synergism; D066246:ErbB Receptors / Q000037:antagonists & inhibitors; D005260:Female; D000077156:Gefitinib; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008875:Middle Aged; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D011799:Quinazolines / Q000008:administration & dosage / Q000494:pharmacology*; D013927:Thrombosis / Q000188:drug therapy; D014859:Warfarin / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D011799:Quinazolines; D014859:Warfarin; D066246:ErbB Receptors; D000077156:Gefitinib