Involvement of H2-receptors in the mechanism of analgesic action of Tyr-MIF-1.
The antinociceptive effects of H2-agents cimetidine (CIM) and dimaprit (DMP) as well as their effects on the Tyr-MIF-1-evoked analgesia have been studied after intraperitoneal (i.p.) administration in rats. In the paw-pressure (PP) test Tyr-MIF-1 (1 mg/kg), CIM (50 and 100mg/kg) and DMP (5 and 10mg/kg) induced analgesia. Injected before DMP, naloxone (NAL) and CIM diminished or completely prevented the pain-relieving effect of H2-agonist DMP. The antinociceptive effect of Tyr-MIF-1 has been potentiated by DMP dose-dependently. CIM (50mg/kg) decreased the antinociceptive action of the combination Tyr-MIF-1 + DMP, while CIM (100mg/kg) expressed a weaker inhibitory effect on it. The data obtained clearly show that H2-receptor activation is involved in the mechanism of the Tyr-MIF-1 antinociceptive action.
Zamfirova
R
R
Institute of Physiology, Bulgarian Academy of Sciences, Bulgaria.
Bocheva
A
A
Todorov
S
S
D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002927:Cimetidine / Q000008:administration & dosage / Q000494:pharmacology; D017259:Dimaprit / Q000008:administration & dosage / Q000494:pharmacology; D004195:Disease Models, Animal; D007274:Injections, Intraperitoneal; D009075:MSH Release-Inhibiting Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology; D009619:Nociceptors / Q000187:drug effects* / Q000378:metabolism; D010147:Pain Measurement; D011312:Pressure; D051381:Rats; D011970:Receptors, Histamine H2 / Q000378:metabolism*; D012018:Reflex / Q000187:drug effects* / Q000502:physiology
D000700:Analgesics; D011970:Receptors, Histamine H2; D009270:Naloxone; C036930:tyrosyl-prolyl-leucyl-glycinamide; D002927:Cimetidine; D009075:MSH Release-Inhibiting Hormone; D017259:Dimaprit