Study of the reproductive effects in rats surgically implanted with depleted uranium for up to 90 days.
In 2001, the Naval Health Research Center Toxicology Detachment was funded by the U.S. Army Medical Research Acquisition Activity (USAMRAA) to conduct a study of the effects of surgically implanted depleted uranium (DU) pellets on adult rat reproductive success and development across two successive generations. This article presents some of the findings for the group of offspring from adult rats mated at 30 d post surgical implantation of DU pellets. Adult male and female Sprague-Dawley rats (P1 generation) were surgically implanted with 0, 4, 8, or 12 DU pellets (1 x 2 mm). The P1 generation was then cross-mated at 30 d post surgical implantation. Urine collected from P1 animals at 27 d post surgical implantation showed that DU was excreted in the urine of DU-implanted animals in a dose-dependent manner. DU surgical implantation did not have a negative impact on P1 reproductive success, survival, or body weight gain through post surgical implantation d 90. There were no statistically significant differences in F1 birth weight, survival, and litter size at postnatal day (PND) 0, 5, and 20. No gross physical abnormalities identified in the offspring were attributable to neonatal DU exposure. A series of neurodevelopment and immune function assessments were also conducted on F1 offspring. No group differences were observed that were related to parental DU exposure. Studies are ongoing on the impact of leaving DU embedded in soft tissue for 120 d on rat reproduction and subsequent offspring survival and development.
Arfsten
D P
DP
Naval Health Research Center Detachment, Environmental Health Effects Laboratory, Wright-Patterson AFB, Ohio, USA. darryl.arfsten@wpafb.af.mil
Bekkedal
M
M
Wilfong
E R
ER
Rossi
J
J
Grasman
K A
KA
Healey
L B
LB
Rutkiewicz
J M
JM
Johnson
E W
EW
Thitoff
A R
AR
Jung
A E
AE
Lohrke
S R
SR
Schaeffer
D J
DJ
Still
K R
KR
D000818:Animals; D004334:Drug Administration Schedule; D004343:Drug Implants; D005260:Female; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012098:Reproduction / Q000187:drug effects*; D013081:Sperm Motility; D013154:Spleen / Q000187:drug effects; D013950:Thymus Gland / Q000187:drug effects; D014501:Uranium / Q000008:administration & dosage / Q000633:toxicity*; D014828:Vocalization, Animal / Q000187:drug effects; D015430:Weight Gain / Q000187:drug effects
D004343:Drug Implants; D014501:Uranium