title: Heat shock proteins HSP70 and GP96: structural insights.
abstract: Several heat shock proteins (HSPs) act as potent adjuvants for eliciting anti-tumor immunity. HSP-based tumor vaccine strategies have been highly successful in animal models and are undergoing testing in clinical trials. It is generally accepted that HSPs, functioning as chaperones for tumor antigens, elicit tumor-specific adaptive immune responses. HSPs also appear to induce innate immune responses in an antigen-independent fashion. Innate responses generated by HSPs may contribute to anti-tumor immunity. Immunologically active chaperones with anti-tumor activity are referred to as "immunochaperones". Here, we review the studies that address the role of structural domains or regions of the immunochaperones HSP70 and GP96 that may be involved in the induction of adaptive or innate immune responses.
authors: Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. john.facciponte@roswellpark.org
authors: John G
authors: JG
authors: Facciponte
authors: Xiang-Yang
authors: XY
authors: Wang
authors: Ian J
authors: IJ
authors: MacDonald
authors: Jun-eui
authors: JE
authors: Park
authors: Hilal
authors: H
authors: Arnouk
authors: Melissa J
authors: MJ
authors: Grimm
authors: Ying
authors: Y
authors: Li
authors: Hyung
authors: H
authors: Kim
authors: Masoud H
authors: MH
authors: Manjili
authors: Douglas P
authors: DP
authors: Easton
authors: John R
authors: JR
authors: Subjeck
mesh_terms: D000818:Animals; D019496:Cancer Vaccines / Q000276:immunology; D018840:HSP70 Heat-Shock Proteins / Q000737:chemistry* / Q000276:immunology*; D006801:Humans; D008562:Membrane Glycoproteins / Q000737:chemistry* / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*; D013329:Structure-Activity Relationship
chemical_list: D019496:Cancer Vaccines; D018840:HSP70 Heat-Shock Proteins; D008562:Membrane Glycoproteins; C053387:endoplasmin