Octyl 2-cyanoacrylate for repair of peripheral nerve.
The repair of peripheral nerves with sutures is time consuming. The aim of this study was to evaluate the benefits and functional outcome of repairing nerves with octyl 2-cyanoacrylate adhesive. The right peroneal nerve of 64 male, Lewis rats was sectioned and repaired. The rats were randomized into 3 experimental groups: A (n = 27), using only octyl 2-cyanoacrylate; B (n = 27), using 4, 10-0 nylon sutures; and C (n = 10), a sham operation. The recovery of nerve function was quantified through walking-track analyses; group A showed faster return of nerve function than B, especially at 15 days (P < 0.017). Histologic analysis showed a greater axonal regeneration in group A versus group B and no indication of tissue toxicity in group A. No dehiscence occurred during the 6-month study. Use of adhesive shortened the anastomosis time from 12 minutes to 4 minutes. These results indicate that the use of octyl 2-cyanoacrylate adhesive for nerve anastomoses is safe and effective and may have benefits compared with the use of sutures.
Piñeros-Fernández
Angela
A
Department of Plastic Surgery, University of Virginia Health System, Charlottesville, VA 22903-1351, USA.
Rodeheaver
Pamela F
PF
Rodeheaver
George T
GT
D000714:Anastomosis, Surgical; D000818:Animals; D003487:Cyanoacrylates / Q000627:therapeutic use*; D008124:Locomotion; D008297:Male; D010543:Peroneal Nerve / Q000166:cytology / Q000502:physiology / Q000601:surgery*; D011897:Random Allocation; D051381:Rats; D011917:Rats, Inbred Lew; D019651:Plastic Surgery Procedures / Q000379:methods*; D012038:Regeneration / Q000502:physiology
D003487:Cyanoacrylates; C100832:octyl 2-cyanoacrylate