Isarfelin, a peptide with antifungal and insecticidal activities from Isaria felina.
Isarfelin, a peptide with inhibitory activity on mycelial growth in Rhizoctonia solani and Sclerotinia sclerotiorum and insecticidal activity toward Leucania separata, was isolated from the mycelia of Isaria felina. The IC50 value of its antifungal activity against R. solani was 3.1 microg mL(-1). However, it was devoid of activity toward several bacterial species including Bacillus subtilis, E. coli and Staphylococcus aureus. The isolation procedure involved ethanol extraction, adsorption on YPR II macropore adsorption resin, ethyl acetate extraction, petroleum ether precipitation and recrystallization from ethyl acetate.
Guo
Y X
YX
Department of Microbiology, China Agricultural University and State Key Laboratory for Agrobiotechnology, Beijing, China.
Liu
Q H
QH
Ng
T B
TB
Wang
H X
HX
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry* / Q000254:growth & development; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D047630:Depsipeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009036:Moths / Q000187:drug effects / Q000254:growth & development*; D010455:Peptides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012232:Rhizoctonia / Q000187:drug effects / Q000254:growth & development*
D000935:Antifungal Agents; D047630:Depsipeptides; D007306:Insecticides; C508114:Isarfelin A; C508115:Isarfelin B; D010455:Peptides