The effect of probiotics on the genotoxicity of furazolidone.
Antigenotoxic activity of probiotic bacteria against furazolidone was studied using the short-term bacterial assay SOS chromotest, with Escherichia coli PQ37 as the test organism. The supernatants from probiotic and furazolidone co-incubation exhibited rather strong suppression on SOS induction produced by furazolidone on E. coli PQ 37 (sfiA: lacZ). Genotoxicity inhibition was found for all strains of the examined bacteria belonging to three genera. The highest genotoxicity inhibition was detected for Bifidobacterium lactis Bb-12 (92.0%) and for Lactobacillus acidophilus T20 (81.9%).
Raipulis
J
J
Institute of Microbiology and Biotechnology, University of Latvia, Kronvalda boulv. 4, Riga LV-1586, Latvia.
Toma
M M
MM
Semjonovs
P
P
D000891:Anti-Infective Agents, Local / Q000633:toxicity*; D001644:Bifidobacterium / Q000235:genetics / Q000502:physiology*; D005664:Furazolidone / Q000633:toxicity*; D007778:Lactobacillus / Q000235:genetics / Q000502:physiology*; D009152:Mutagenicity Tests; D019936:Probiotics / Q000494:pharmacology*; D013014:SOS Response, Genetics / Q000187:drug effects
D000891:Anti-Infective Agents, Local; D005664:Furazolidone