title: Incidence of atrial fibrillation early after cardiac surgery: can choice of the anesthetic regimen influence the incidence?
abstract: Occurrence of atrial fibrillation is a common complication after coronary surgery. This study aimed to identify the perioperative factors that are associated with its occurrence with specific attention to the possible influence of the choice of the anesthetic regimen after elective coronary surgery. A retrospective chart analysis was performed in 460 patients who underwent elective coronary artery surgery with cardiopulmonary bypass using the standard institutional anesthetic, surgical and postoperative protocols. The only difference in management was the choice of the primary anesthetic regimen. 110 patients had a total intravenous anesthesia with propofol, 90 patients had a total intravenous anesthesia with midazolam, 150 patients were anesthetized with sevoflurane and 110 patients with desflurane. The primary outcome variable was the incidence of atrial fibrillation within the first 24 postoperative hours. Atrial fibrillation occurred in 64 of the 460 patients included (13.9%). Multiple logistic regression analysis identified increased age (> 70 years), EuroSCORE > 4, prolonged CPB time (> 100 min) and need for prolonged inotropic support (> 6 hours) as the significant independent risk factors for the occurrence of postoperative atrial fibrillation. The incidence of postoperative atrial fibrillation differed among the different anesthetic groups with the lowest incidence in the sevoflurane group (propofol: 17/110; midazolam: 15/90; sevoflurane: 9/150; desflurane: 23/110) (p = 0.004). This finding should be further confirmed in a prospective sufficiently powered multicenter study.
authors: Department of Anesthesiology, University Hospital Antwerp, Belgium.
authors: S
authors: S
authors: Cromheecke
authors: P W
authors: PW
authors: ten Broecke
authors: E
authors: E
authors: Hendrickx
authors: R
authors: R
authors: Meeus
authors: S G
authors: SG
authors: De Hert
mesh_terms: D000367:Age Factors; D000368:Aged; D000758:Anesthesia; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D000777:Anesthetics / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000453:epidemiology* / Q000517:prevention & control*; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D002316:Cardiotonic Agents; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology* / Q000517:prevention & control*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000777:Anesthetics; D002316:Cardiotonic Agents