title: Pharmacokinetic changes of DA-8159, a new erectogenic, and one of its metabolites, DA-8164 after intravenous and oral administration of DA-8159 to spontaneously hypertensive rats and DOCA-salt-induced hypertensive rats.
abstract: The pharmacokinetics of DA-8159 and one of its metabolites, DA-8164, were compared after intravenous and oral administration of DA-8159 at a dose of 30 mg/kg to spontaneously hypertensive rats (SHRs) at 16 and 6 weeks old and their respective age-matched control normotensive Kyoto-Wistar rats (KW rats), and deoxycorticosterone acetate-salt-induced hypertensive rats (DOCA-salt rats) at 16 weeks old and their age-matched control Sprague-Dawley rats. After oral administration of DA-8159 to 16-week-old SHRs, the AUC values of both DA-8159 (157 versus 103 microg min/ml) and DA-8164 (215 versus 141 microg min/ml) were significantly greater, but the values of DA-8159 were reversed in 16-week-old DOCA-salt rats (125 versus 200 microg min/ml). However, the AUC values of both DA-8159 and DA-8164 were not significantly different between the 6-week-old SHRs and their control rats. The above AUC differences in 16-week-old SHRs may be due to neither hereditary characteristics of SHRs nor the hypertensive state itself.
authors: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Republic of Korea.
authors: Yu C
authors: YC
authors: Kim
authors: Hyun J
authors: HJ
authors: Shim
authors: Joo H
authors: JH
authors: Lee
authors: Dong S
authors: DS
authors: Kim
authors: Jong W
authors: JW
authors: Kwon
authors: Won B
authors: WB
authors: Kim
authors: Inchul
authors: I
authors: Lee
authors: Myung G
authors: MG
authors: Lee
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D003900:Desoxycorticosterone; D006207:Half-Life; D006973:Hypertension / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism*; D007275:Injections, Intravenous; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D010726:Phosphodiesterase Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics*; D010879:Piperazines / Q000493:pharmacokinetics; D011687:Purines; D011743:Pyrimidines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D011918:Rats, Inbred SHR; D017207:Rats, Sprague-Dawley; D000068677:Sildenafil Citrate; D012965:Sodium Chloride; D013449:Sulfonamides; D013450:Sulfones; D000096926:Benzenesulfonamides
chemical_list: D003900:Desoxycorticosterone; D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D011743:Pyrimidines; D000068677:Sildenafil Citrate; D012965:Sodium Chloride; D013449:Sulfonamides; D013450:Sulfones; C419664:udenafil; D000096926:Benzenesulfonamides