title: [Familial hypertriglyceridemia and diabetes mellitus type 2].
abstract: Hypertriglyceridemia is a cardiovascular risk factor in type-2 diabetes. However, this abnormality may be caused by several mechanisms. In familial hypertriglyceridemia, a hyperlipidemia associated with type-2 diabetes, plasma accumulation of non atherogenic particles explains the presence of hypertriglyceridemia. Our objective was to compare the prevalence of coronary insufficiency and carotid artery stenosis in patients with type-2 diabetes with or without familial hypertriglyceridemia. Controls were paired against cases based on age, gender, diabetes duration, treatment and other cardiovascular risk factors. Controls had either a normal lipid profile (n=48) or hyperlipidemia (n=15). The intima-media thickness of the carotid arteries was significantly lower in cases compared to controls (0.55 +/- 0.12 vs 0.63 +/- 0.22 in normolipidemic controls and 0.66 +/- 0.18 mm in hyperlipidemic subjects (p=0.02)). Exercise treadmill testing was abnormal in a similar proportion of cases and controls (4.8 vs 6.2%). Incidence of cardiovascular complications was not different between groups. We therefore conclude that severe hypertriglyceridemia due to familial hypertriglyceridemia is not associated with an increased prevalence of symptomatic atherosclerosis in patients with type-2 diabetes.
authors: Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México DF, México. caguilarsalinas@yahoo.com
authors: Carlos Alberto
authors: CA
authors: Aguilar-Salinas
authors: Erika
authors: E
authors: Ramírez-Moguel
authors: José
authors: J
authors: Gallegos-Martínez
authors: Octavio
authors: O
authors: Leyva
authors: Jorge
authors: J
authors: Oseguera
authors: Horacio
authors: H
authors: Lozano
authors: Francisco
authors: F
authors: Gómez-Pérez
mesh_terms: D016893:Carotid Stenosis / Q000150:complications; D016022:Case-Control Studies; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006801:Humans; D006953:Hyperlipoproteinemia Type IV / Q000150:complications*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged