title: Report: workshop on mediastinal grey zone lymphoma.
abstract: There are several indications that classical Hodgkin lymphoma (cHL) and at least a proportion of cases of Primary Mediastinal B cell Lymphoma (PMBL) are derived from B cells at similar stages of differentiation and share common pathogenic mechanisms. The first indication was the existence of mediastinal grey zone lymphomas as identified in the 4th International Symposium on HL, with clinical, histological and immunohistochemical features intermediate between cHL and PMBL. Second, both tumor types resemble a cell that is developmentally situated in-between the germinal center reaction and a plasma cell. Third, cHL and PMBL were found to have similar gene expression profiles, including the lack of immunoglobulin expression and low levels of B cell receptor signalling molecules, and the secretion of molecules like the chemokine TARC and the prominent expression of IL-13 receptors. Fourth, both entities were found to have common genomic aberrancies, notably in 2p15 and 9p24, the sites of the REL oncogene and the tyrosine kinase gene JAK2, respectively. Further comparison of both lymphoma types may provide further insight in the pathogenic mechanisms and allow the design of diagnostic algorithms to sort out the small number of so-called mediastinal grey zone lymphomas, that appear to be intermediate between PMBL and cHL.
authors: Department of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen De Brug, Rm 9.14, Hanzeplein 1, 9700 RB Groningen, The Netherlands. s.poppema@med.rug.nl
authors: Sibrand
authors: S
authors: Poppema
authors: Joost L
authors: JL
authors: Kluiver
authors: Cigdem
authors: C
authors: Atayar
authors: Anke
authors: A
authors: van den Berg
authors: Andreas
authors: A
authors: Rosenwald
authors: Michael
authors: M
authors: Hummel
authors: Dido
authors: D
authors: Lenze
authors: Hetty
authors: H
authors: Lammert
authors: Harald
authors: H
authors: Stein
authors: Stephan
authors: S
authors: Joos
authors: Thomas
authors: T
authors: Barth
authors: Martin
authors: M
authors: Dyer
authors: Peter
authors: P
authors: Lichter
authors: Uwe
authors: U
authors: Klein
authors: Giorgio
authors: G
authors: Cattoretti
authors: Annunziata
authors: A
authors: Gloghini
authors: Yuhai
authors: Y
authors: Tu
authors: Gustavo A
authors: GA
authors: Stolovitzky
authors: Andrea
authors: A
authors: Califano
authors: Antonino
authors: A
authors: Carbone
authors: Ricardo
authors: R
authors: Dalla-Favera
authors: Ingo
authors: I
authors: Melzner
authors: Alexandra J
authors: AJ
authors: Bucur
authors: Silke
authors: S
authors: Brüderlein
authors: Karola
authors: K
authors: Dorsch
authors: Cornelia
authors: C
authors: Hasel
authors: Thomas F E
authors: TF
authors: Barth
authors: Frank
authors: F
authors: Leithäuser
authors: Peter
authors: P
authors: Möller
mesh_terms: D001402:B-Lymphocytes / Q000378:metabolism / Q000473:pathology; D002869:Chromosome Aberrations; D004493:Education; D015973:Gene Expression Regulation, Leukemic; D006689:Hodgkin Disease / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D008479:Mediastinal Neoplasms / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*