title: Synthesis and biological activity of M6-P and M6-P analogs on fibroblast and keratinocyte proliferation.
abstract: A new synthetic route to obtain the carboxylate analog of mannose 6-phosphate (M6-P) is presented. The effects of the M6-P, the carboxylate and two other analogs (the phosphonate and the alpha,beta ethylenic carboxylate) on the proliferation of human keratinocytes and dermal fibroblasts as well as on the proliferation of a murine fibroblast cell line, 3T3-J2 are tested. We observed that M6-P is a potent inhibitor of proliferation of both fibroblasts and keratinocytes. Among its analogs, the phosphonate showed a similar effect on human dermal fibroblasts but not on keratinocytes.
authors: Laboratoire de Chimie Biomoléculaire, FRE 5032 (UM2, CNRS), ERT 5-ENSCM, Montpellier cedex 5, France.
authors: Caroline
authors: C
authors: Clavel
authors: Véronique
authors: V
authors: Barragan-Montero
authors: Xavier
authors: X
authors: Garric
authors: Jean-Pierre
authors: JP
authors: Molès
authors: Jean-Louis
authors: JL
authors: Montero
mesh_terms: D016475:3T3 Cells; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects*; D008360:Mannosephosphates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice
chemical_list: D008360:Mannosephosphates; C027693:mannose-6-phosphate