Etoposide, cisplatin, epirubicin chemotherapy in the treatment of pediatric liver tumors.
To discuss the potential benefit of a chemotherapy regimen including etoposide (etoposide, cisplatin, epirubicin [EPE]), the authors report a single-institutional experience regarding 13 children with hepatoblastoma (HB) and 7 with hepatocellular carcinoma (HCC). Chemotherapy achieved partial response in 8/9 HB and in 4/5 HCC. Eight initially unresectable HB subsequently had liver resection. Event-free survival and overall survival at 5 years were 84 and 88% for HB (non-metastatic cases: 91 and 100%), 29% for HCC. EPE chemotherapy seems to be effective in the treatment of childhood malignant liver tumors. Etoposide could be suggested as part of intensive multidrug regimens for HCC and high-risk HB.
Casanova
Michela
M
Pediatric Oncology Unit, Istituto Nazionale Tumori, Via Venezian, 1-20133 Milano, Italy. michela.casanova@istitutotumori.mi.it
Massimino
Maura
M
Ferrari
Andrea
A
Spreafico
Filippo
F
Piva
Luigi
L
Coppa
Jorgelina
J
Luksch
Roberto
R
Cefalo
Graziella
G
Terenziani
Monica
M
Polastri
Daniela
D
Bellani
Franca Fossati
FF
Mazzaferro
Vincenzo
V
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects; D015251:Epirubicin / Q000008:administration & dosage* / Q000009:adverse effects; D005047:Etoposide / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D018197:Hepatoblastoma / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D016019:Survival Analysis; D016896:Treatment Outcome
D015251:Epirubicin; D005047:Etoposide; D002945:Cisplatin