title: [Immunohistochemical evidence for HIV-1 infection in the liver of HIV-infected patients].
abstract: OBJECTIVE
  To detect p24 antigen of human immunodeficiency virus (HIV)-1 in the liver biopsy specimens of patients with HIV infection.
  
  
  METHODS
  Liver biopsy samples from 14 patients with HIV/AIDS (11 man, 3 women; age range 27-52 years; infection time range 8-13 years) were examined by immunohistochemistry prospectively.
  
  
  RESULTS
  Intracellular expression of HIV-1 p24 antigen was detected in Kupffer cells, endothelial cells and hepatocytes. There were more HIV-positive liver cells in the patients with severer liver damage than those with milder liver damage (t=2.5189, P=0.0270).
  
  
  CONCLUSIONS
  These findings indicate that HIV-1 could replicate in the liver of HIV-infected patients and might be related to the liver cells apoptosis.
authors: The No. 302 Hospital of The People's Liberation Army, Beijing 100039, China. med6677@yahoo.com.cn
authors: Tian-jun
authors: TJ
authors: Jiang
authors: Min
authors: M
authors: Zhao
authors: Jing-min
authors: JM
authors: Zhao
authors: Guang-de
authors: GD
authors: Zhou
authors: Deng
authors: D
authors: Pan
authors: Jian
authors: J
authors: Wang
authors: Yun-hui
authors: YH
authors: Zhang
authors: Zhi-ping
authors: ZP
authors: Zhou
mesh_terms: D000328:Adult; D005260:Female; D016655:HIV Core Protein p24 / Q000096:biosynthesis*; D015658:HIV Infections / Q000378:metabolism* / Q000821:virology; D015497:HIV-1 / Q000502:physiology*; D022781:Hepatocytes / Q000378:metabolism* / Q000473:pathology; D054884:Host-Pathogen Interactions; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged
chemical_list: D016655:HIV Core Protein p24