Radical crosslinked albumin microspheres as potential drug delivery systems: preparation and in vitro studies.
This article reports on the preparation of acryloylated bovine serum albumin microspheres and the evaluation of their employment in drug delivery areas. The influence of preparation parameters on albumin microspheres and the chemicophysical properties of loaded drugs were investigated. In particular, we focussed on acylation albumin degree and the amount of acryloylated albumin against comonomer in the polymerization step. Finally the release profile took into consideration the interaction drug-matrix, the fuctionalization degree of albumin, and the water affinity of matrix.
Iemma
F
F
Dipartimento di Scienze Farmaceutiche, Università della Calabria, Rende (CS), Italy. francesca.iemma@unical.it
Spizzirri
U G
UG
Puoci
F
F
Muzzalupo
R
R
Trombino
S
S
Picci
N
N
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D000818:Animals; D002417:Cattle; D003432:Cross-Linking Reagents / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D005472:Fluorouracil / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D006863:Hydrogen-Ion Concentration; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry; D011433:Propranolol / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D003432:Cross-Linking Reagents; D007166:Immunosuppressive Agents; D004364:Pharmaceutical Preparations; D012710:Serum Albumin, Bovine; D011433:Propranolol; D005472:Fluorouracil