title: fMRI study of language lateralization in children and adults.
abstract: Language lateralization in the brain is dependent on family history of handedness, personal handedness, pathology, and other factors. The influence of age on language lateralization is not completely understood. Increasing left lateralization of language with age has been observed in children, while the reverse has been noted in healthy young adults. It is not known whether the trend of decreasing language lateralization with age continues in the late decades of life and at what age the inflection in language lateralization trend as a function of age occurs. In this study, we examined the effect of age on language lateralization in 170 healthy right-handed children and adults ages 5-67 using functional MRI (fMRI) and a verb generation task. Our findings indicate that language lateralization to the dominant hemisphere increases between the ages 5 and 20 years, plateaus between 20 and 25 years, and slowly decreases between 25 and 70 years.
authors: Department of Neurology, University of Cincinnati Medical Center, Cincinnati, Ohio 45267-0525, USA. Jerzy.Szaflarski@uc.edu
authors: Jerzy P
authors: JP
authors: Szaflarski
authors: Scott K
authors: SK
authors: Holland
authors: Vincent J
authors: VJ
authors: Schmithorst
authors: Anna W
authors: AW
authors: Byars
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000375:Aging / Q000502:physiology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000254:growth & development*; D002648:Child; D002675:Child, Preschool; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007802:Language; D007807:Language Tests; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D012044:Regression Analysis; D014705:Verbal Behavior / Q000502:physiology*