title: Transcutaneous iodine absorption in adult patients with thyroid cancer disinfected with povidone-iodine at operation.
abstract: Povidone-iodine is used as disinfection in patients undergoing many kinds of operations. Several cases of thyroid dysfunction induced by transcutaneous absorption of povidone-iodine have been reported in small infants. However, transcutaneous absorption was not clearly reported in adults. The aim of this study was to assess transcutaneous absorption of iodine in patients who received single topical application with povidoneiodine and serial changes of urinary iodine excretion under the condition with a simple iodine-restricted diet in Japan, an iodine-sufficient area. Sixty-eight patients with thyroid carcinoma undergoing total thyroidectomy received single skin disinfection with either povidone-iodine (group A; n = 47) or chlohexidine gluconate, a noniodine containing biguanide (group B; n = 21). In group A, urinary iodine excretion on the first day after operation increased up to 7 times that of the preoperative value. The amounts of urinary iodine correlated positively with operating time. Increased urinary iodine, however, returned to preoperative values on the third or fifth day after operation. In group B, there was no increase in urinary iodine excretion and urinary iodine excretion was ranged from 54 to 193 microg/g of creatinine on the third day of operation. In conclusion, a large amount of povidone-iodine was absorbed through healthy skin even in adults. This may possibly interfere with scintigraphy or radioactive iodine treatment, or cause thyroid disinfection in susceptible patients.
authors: Kuma Hospital, Kobe, Japan. tomoda@kuma-h.or.jp
authors: Chisato
authors: C
authors: Tomoda
authors: Hiroya
authors: H
authors: Kitano
authors: Takashi
authors: T
authors: Uruno
authors: Yuuki
authors: Y
authors: Takamura
authors: Yasuhiro
authors: Y
authors: Ito
authors: Akihiro
authors: A
authors: Miya
authors: Kaoru
authors: K
authors: Kobayashi
authors: Fumio
authors: F
authors: Matsuzuka
authors: Nobuyuki
authors: N
authors: Amino
authors: Kanji
authors: K
authors: Kuma
authors: Akira
authors: A
authors: Miyauchi
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007455:Iodine / Q000652:urine; D008297:Male; D008875:Middle Aged; D011206:Povidone-Iodine / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D011300:Preoperative Care; D012869:Skin Absorption / Q000502:physiology*; D013961:Thyroid Gland / Q000601:surgery; D013964:Thyroid Neoplasms / Q000601:surgery* / Q000652:urine; D013965:Thyroidectomy
chemical_list: D000891:Anti-Infective Agents, Local; D011206:Povidone-Iodine; D007455:Iodine