[Experimentally determined safety and immunological activity of vaccine based on antigens isolated from Pseudomonas aeruginosa in medium K-4].
The safety and immunological activity of P. aeruginosa vaccine were experimentally evaluated. The vaccine was prepared on the basis of the antigens of P. aeruginosa extracellular slime which was accumulated in medium K-4, obtained with the use of original technology. The immunization of animals with P. aeruginosa vaccine induced the synthesis of antibodies. The introduction of the vaccine in 2 or 3 injections resulted in a high level of antibody formation, differing with the use of various strains. Hyperimmune sera, obtained by the multiple immunization of rabbits with P. aeruginosa vaccine, ensured high protection of mice from P. aeruginosa infection. The vaccine proved to be safe when evaluated in experiments of acute and chronic toxicity, made on laboratory animals.
Nuriddinova
N R
NR
Sheremet'ev
N N
NN
Ivanova
L E
LE
Garib
F Iu
FIu
Iskhakova
Kh I
KhI
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000918:Antibody Specificity; D000942:Antigens, Bacterial / Q000276:immunology* / Q000633:toxicity; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000302:isolation & purification / Q000633:toxicity; D003470:Culture Media; D019811:Hydroxylamine; D007279:Injections, Subcutaneous; D051379:Mice; D011552:Pseudomonas Infections / Q000276:immunology / Q000517:prevention & control*; D011550:Pseudomonas aeruginosa / Q000254:growth & development / Q000276:immunology*; D011817:Rabbits; D014611:Vaccination
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D003470:Culture Media; D019811:Hydroxylamine