Analysis of HLA class I and class II gene polymorphisms in Japanese patients with human T-cell lymphotropic virus type 1-associated uveitis.
OBJECTIVE
To investigate the immunogenetic background of human T-cell lymphotropic virus type 1 (HTLV-1)-associated uveitis (HAU) that presents immune-mediated reactive changes in the uvea.


METHODS
HLA class I and class II genes were studied in 51 patients with HAU, 192 asymptomatic HTLV-1 carriers, and 266 HTLV-1-seronegative controls using a high-resolution method of HLA DNA typing. The HLA alleles of HAU were compared with those of HTLV-1 carriers and healthy controls.


RESULTS
We identified 62 distinct alleles of HLA-A, HLA-Cw, and HLA-B and 49 distinct alleles of HLA-DRB1 and HLA-DQB1 in patients with HAU, asymptomatic HTLV-1 carriers, and healthy controls. The relative frequencies of these HLA alleles did not differ among the three groups.


CONCLUSIONS
The results suggest that HLA class I and class II genes do not contribute to susceptibility to HAU.
Kaminagayoshi
Tatsuhiko
T
Department of Ophthalmology, Kagoshima University Faculty of Medicine, Japan.
Nakao
Kumiko
K
Yashiki
Shinji
S
Sonoda
Shunro
S
Ohba
Norio
N
Sakamoto
Taiji
T
D000483:Alleles; D000914:Antibodies, Viral / Q000276:immunology; D044466:Asian People / Q000235:genetics*; D004247:DNA / Q000235:genetics; D015828:Eye Infections, Viral / Q000208:ethnology / Q000235:genetics / Q000276:immunology; D005787:Gene Frequency; D005805:Genes, MHC Class I / Q000235:genetics*; D005802:Genes, MHC Class II / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015490:HTLV-I Infections / Q000208:ethnology / Q000235:genetics / Q000276:immunology*; D006650:Histocompatibility Testing; D015368:Human T-lymphotropic virus 1 / Q000276:immunology; D006801:Humans; D007564:Japan / Q000208:ethnology; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012189:Retrospective Studies; D014605:Uveitis / Q000208:ethnology / Q000235:genetics / Q000276:immunology*
D000914:Antibodies, Viral; D004247:DNA