title: Neuronal cell injury in patients after cardiopulmonary resuscitation: evaluation by diffusion-weighted imaging and magnetic resonance spectroscopy.
abstract: Neuronal cell injury after global cerebral ischemic insult is not well understood in humans. We performed serial examination of diffusion-weighted imaging and magnetic resonance spectroscopy in three patients after cardiopulmonary resuscitation. The presence of the signal for lactate in magnetic resonance spectroscopy in the acute stage after cardiopulmonary resuscitation was closely correlated to irreversible damage. In addition, high intensity in diffusion-weighted magnetic resonance image in the acute stage also predicted a poor outcome. Lesions that were positive for these factors in the acute stage led to serious brain damage in the subacute and chronic stages. The results indicated that after cardiopulmonary resuscitation, diffusion-weighted magnetic resonance imaging and magnetic resonance spectroscopy is an extremely useful modality to estimate the prognosis of patients, which is not always easy using conventional methods.
authors: Department of Emergency Medical Center, School of Medicine, Sapporo Medical University, Sapporo, Japan.
authors: Hitoshi
authors: H
authors: Kano
authors: Kiyohiro
authors: K
authors: Houkin
authors: Kuniaki
authors: K
authors: Harada
authors: Izumi
authors: I
authors: Koyanagi
authors: Satoshi
authors: S
authors: Nara
authors: Yasushi
authors: Y
authors: Itou
authors: Hitoshi
authors: H
authors: Imaizumi
authors: Yasufumi
authors: Y
authors: Asai
authors: Masaki
authors: M
authors: Saitou
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000032:analysis; D001921:Brain / Q000473:pathology; D002545:Brain Ischemia / Q000150:complications / Q000473:pathology*; D016887:Cardiopulmonary Resuscitation; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D006323:Heart Arrest / Q000150:complications / Q000473:pathology; D006801:Humans; D007773:Lactates / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration / Q000209:etiology / Q000473:pathology*; D009474:Neurons / Q000473:pathology*; D011379:Prognosis
chemical_list: D015415:Biomarkers; D007773:Lactates