title: Practical preparation of 3,3-difluoropyrrolidine.
abstract: A practical and cost-effective synthesis of 3,3-difluoropyrrolidine is reported. The synthesis involves the isolation of two intermediates, which are prepared via two efficient through processes: (1) a Claisen rearrangement followed by a Ru(VIII)-catalyzed oxidation to prepare the 2,2-difluorosuccinic acid and (2) an efficient cyclization to form N-benzyl-3,3-difluoropyrrolidinone followed by BH(3).Me(2)S reduction.
authors: Department of Process Research, Merck Research Laboratories, Rahway, NJ 07065, USA. feng_xu@merck.com
authors: Feng
authors: F
authors: Xu
authors: Bryon
authors: B
authors: Simmons
authors: Joseph
authors: J
authors: Armstrong
authors: Jerry
authors: J
authors: Murry