[Protective effects of shenmai injection on the delayed injury of the cerebral neurons in rat induced by intracerebral hemorrhage].
OBJECTIVE
To observe protective effects of Shenmai (SM) injection on the delayed injury of the cerebral neurons in rat with intracerebral hemorrhage.


METHODS
Rosenberg models of intracerebral hemorrhage was established and the effects of SM injection on the pathologic changes in neuronal structure, mitochondria-DNA(mtDNA)deletion, C-myc gene and expression PDGF-A gene in hippocampal CA1 areas, were investigated.


RESULTS
SM injection inhibited the apoptosis of pyramidal cells in the hippocampal CA1 areas, and decreased the degree of mtDNA deletion in the neurons in the injured area. SM injection had no effect on gene expression of C-myc at initial stage a intracerebral hemorrhage, but significantiy decreased the level of PDGF-A mRNA and prolonged the time of its expression.


CONCLUSIONS
SM injection might attenuate the delayed injury induced by intracerebral hemorrhage via regulating the expression of PDGF.
He
Ze-yun
ZY
The Postdoctrate Research Centre of The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, China. hzywjL2003@yahoo.com.cn
Lu
Xiao-feng
XF
Qu
Bo
B
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002543:Cerebral Hemorrhage / Q000378:metabolism / Q000473:pathology; D004272:DNA, Mitochondrial / Q000235:genetics; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D017353:Gene Deletion; D006624:Hippocampus / Q000473:pathology; D008297:Male; D009474:Neurons / Q000187:drug effects; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D031441:Ophiopogon / Q000737:chemistry; D005894:Panax / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010982:Platelet-Derived Growth Factor / Q000096:biosynthesis* / Q000235:genetics; D017966:Pyramidal Cells / Q000473:pathology; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley
D004272:DNA, Mitochondrial; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D010982:Platelet-Derived Growth Factor; D012333:RNA, Messenger; C075278:platelet-derived growth factor A