title: HIV incidence and factors contributed to retention in a 12-month follow-up study of injection drug users in Sichuan Province, China.
abstract: HIV-1 seroconversion and subtype were evaluated, and factors associated with cohort retention were analyzed for subjects' baseline sociodemographic and behavioral characteristics in a 12-month follow-up study of injection drug users (IDUs). In November 2002, a community-based baseline survey was conducted to recruit 333 HIV-seronegative IDUs for a prospective cohort study in Xichang County of Sichuan Province, China. During the 12-month follow-up period, HIV incidence was 3.17 per 100 person-years (95% confidence interval [CI]: 0.98, 5.37), and all subtypes of 8 HIV-1 seroconversions were CRF_07BC. The retention rate at the 12-month follow-up visit was 70.3% (234 of 333 subjects). In a multiple logistic regression model, ethnicity (OR = 0.60, 95% CI: 0.34, 1.04) and appearing at the 6-month follow-up visit (OR = 9.03, 95% CI: 5.14, 15.89) were independently associated with retention. No drug-using or sexual behaviors were found to be associated with retention. This study confirmed one of drug-trafficking routes in mainland China, from Yunnan to Sichuan and then to Xinjiang. This study also suggested that HIV is spreading rapidly to more geographic areas along drug-trafficking routes in China, and a short-term follow-up rate may predict a long-term retention rate in this IDU cohort.
authors: National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing.
authors: Yuhua
authors: Y
authors: Ruan
authors: Guangming
authors: G
authors: Qin
authors: Shizhu
authors: S
authors: Liu
authors: Hanzhu
authors: H
authors: Qian
authors: Li
authors: L
authors: Zhang
authors: Feng
authors: F
authors: Zhou
authors: Yixin
authors: Y
authors: He
authors: Kanglin
authors: K
authors: Chen
authors: Lu
authors: L
authors: Yin
authors: Xianhuang
authors: X
authors: Chen
authors: Qinlin
authors: Q
authors: Hao
authors: Hui
authors: H
authors: Xing
authors: Yanhui
authors: Y
authors: Song
authors: Yunxia
authors: Y
authors: Wang
authors: Kunxue
authors: K
authors: Hong
authors: Jianping
authors: J
authors: Chen
authors: Yiming
authors: Y
authors: Shao
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D010352:Patient Dropouts; D011446:Prospective Studies; D012307:Risk Factors; D012725:Sexual Behavior; D015819:Substance Abuse, Intravenous / Q000150:complications*