title: Comparison of serum cardiac troponin T and creatine kinase MB isoenzyme mass concentrations in asphyxiated term infants during the first 48 h of life.
abstract: OBJECTIVE
  This prospective study aimed to compare serum creatine kinase MB isoenzyme (CK-MB) mass concentrations and cardiac troponin T (cTnT) concentrations during the first 48 h of life in asphyxiated term infants.
  
  
  METHODS
  Serum cTnT and CK-MB mass concentrations of 50 term infants with clinical features of perinatal asphyxia were measured at birth and at 12, 24 and 48 h of age by chemiluminescence immunoassay. These infants were followed up until discharge or death. Cord blood CK-MB and cTnT concentrations of 50 healthy term infants were also assayed.
  
  
  RESULTS
  At birth, asphyxiated infants had significantly higher concentrations of cTnT and CK-MB than controls (P < 0.0001). Serum cTnT of asphyxiated infants with low ejection fraction <60% was significantly higher at 12 and 24 h than those with normal ejection fraction (P < 0.05). Asphyxiated infants with congestive cardiac failure had significantly higher serum cTnT concentration during the first 48 h of life than those without congestive cardiac failure (P <or= 0.04). Serum cTnT concentrations during the first 48 h of life were significantly higher in asphyxiated infants who died than those who survived (P < 0.0001). There was no significant difference in serum CK-MB mass concentrations between asphyxiated infants with and without these complications (P >or= 0.1).
  
  
  CONCLUSIONS
  Unlike CK-MB, serum cTnT concentrations are significantly higher in asphyxiated infants who die or develop cardiac dysfunction.
authors: Department of Paediatrics, Hospital Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. nyboo@mail.hukm.ukm.my
authors: Nem-Yun
authors: NY
authors: Boo
authors: Hasri
authors: H
authors: Hafidz
authors: Hapizah M
authors: HM
authors: Nawawi
authors: Fook-Choe
authors: FC
authors: Cheah
authors: Yong-Junina
authors: YJ
authors: Fadzil
authors: Bilkis B
authors: BB
authors: Abdul-Aziz
authors: Zulkifli
authors: Z
authors: Ismail
mesh_terms: D001238:Asphyxia Neonatorum / Q000097:blood* / Q000201:enzymology; D003402:Creatine Kinase / Q000097:blood*; D052279:Creatine Kinase, MB Form; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007527:Isoenzymes / Q000097:blood; D008296:Malaysia; D008297:Male; D011446:Prospective Studies; D020107:Troponin T / Q000097:blood*
chemical_list: D007527:Isoenzymes; D020107:Troponin T; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form