title: Higher aneuploidy rates of chromosomes 13, 16, and 21 in a patient with globozoospermia.
abstract: OBJECTIVE
  To analyze rates of chromosomal anomalies in a patient with globozoospermia.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Tertiary-care infertility clinic.
  
  
  METHODS
  A 44-year-old man with 100% globozoospermia.
  
  
  METHODS
  Fixation of sperms and analysis of aneuploidies and diploidies by fluorescence in situ hybridization.
  
  
  METHODS
  Aneuploidy rates of chromosomes 13, 16, and 21 and diploidy rate in a patient with 100% globozoospermia.
  
  
  RESULTS
  The aneuploidy rates in spermatozoa from a patient with globozoospermia were significantly higher than in a normospermic man. The incidence of a disomy of the chromosomes 13, 16, and 21 was 4%, 5%, and 1%, respectively, and the nullisomy rates were 2%, 2%, and 3%, respectively.
  
  
  CONCLUSIONS
  This study demonstrates a positive correlation between globozoospermia and higher chromosomal aneuploidies of the chromosomes 13, 16, and 21, suggesting a higher risk of creating aneuploid embryos after intracytoplasmic sperm injection treatment for globozoospermia patients.
authors: Christian Lauritzen-Institut, University of Ulm, Ulm, Germany. nicole.ditzel@gmx.de
authors: Nicole
authors: N
authors: Ditzel
authors: Imam
authors: I
authors: El-Danasouri
authors: Walter
authors: W
authors: Just
authors: Karl
authors: K
authors: Sterzik
mesh_terms: D000328:Adult; D000782:Aneuploidy; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics*; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics*; D006801:Humans; D007248:Infertility, Male / Q000235:genetics; D008297:Male; D013076:Sperm Count / Q000706:statistics & numerical data; D013094:Spermatozoa / Q000002:abnormalities* / Q000502:physiology