title: Cyanovirin-N binding to Manalpha1-2Man functionalized dendrimers.
abstract: Manalpha1-2Man functionalized G(3) and G(4)-PAMAM dendrimers have been synthesized and characterized by MALDI-TOF MS and NMR spectroscopy. Precipitation assays to assess the binding of the dimannose-functionalized dendrimers to Cyanovirin-N, a HIV-inactivating protein that blocks virus-to-cell fusion through high mannose mediated interactions, are presented.
authors: Department of Chemistry and Biochemistry and Center for Bioinspired Nanomaterials, 108 Gaines Hall, Montana State University, Bozeman, MT 59717, USA.
authors: Shane L
authors: SL
authors: Mangold
authors: Joel R
authors: JR
authors: Morgan
authors: Gregory C
authors: GC
authors: Strohmeyer
authors: Angela M
authors: AM
authors: Gronenborn
authors: Mary J
authors: MJ
authors: Cloninger
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry*; D002240:Carbohydrate Sequence; D002352:Carrier Proteins / Q000737:chemistry*; D006678:HIV / Q000187:drug effects / Q000502:physiology; D009682:Magnetic Resonance Spectroscopy; D008358:Mannose / Q000737:chemistry*; D008561:Membrane Fusion / Q000187:drug effects; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; C107733:cyanovirin N; D008358:Mannose