Non-nicotine pharmacotherapies for smoking cessation.
International chronic obstructive pulmonary disease guidelines recommend that smokers be strongly advised to quit, and should be offered help in doing so. The most effective smoking-cessation interventions combine behavioural support with pharmacotherapies. For smokers who do not wish to use nicotine replacement treatments, bupropion is a safe and effective non-nicotine alternative first-line treatment. Nortriptyline and clonidine have demonstrated efficacy in aiding smoking cessation, but are regarded as second-line therapies. A number of other non-nicotine treatments show promise, but more data are required before these can be recommended in assisting smokers to stop.
McRobbie
H
H
Tobacco Dependence Research and Treatment Centre, Barts and The London, Queen Mary's School of Medicine and Dentistry, Turner Street, London E1 2AD, UK. h.mcrobbie@ctru.auckland.ac.nz
Lee
M
M
Juniper
Z
Z
D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D016642:Bupropion / Q000627:therapeutic use; D003000:Clonidine / Q000627:therapeutic use; D018765:Dopamine Uptake Inhibitors / Q000627:therapeutic use; D006801:Humans; D009661:Nortriptyline / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D012907:Smoking / Q000188:drug therapy*; D016540:Smoking Cessation / Q000379:methods*; D000074606:Smoking Prevention
D000316:Adrenergic alpha-Agonists; D000929:Antidepressive Agents, Tricyclic; D018765:Dopamine Uptake Inhibitors; D016642:Bupropion; D009661:Nortriptyline; D003000:Clonidine