Counts of stromal precursor cells in heterotopic splenic transplants in CBA mice of different age.
The content of stromal precursor cells in heterotopic splenic transplants from old and young mice changed appreciably after cross transplantation to old and young animals. The content of CFC-F in the young-->old transplants decreased almost 1.5 times in comparison with the young-->young transplants, the counts of CFC-F in old-->old transplants were minimum in comparison with all other groups (2.5+/-0.1), while in the old-->young group transplants this value increased almost 8-fold (to 19.0+/-1.3) and surpassed the control level. Age-associated shifts in the splenic stromal tissue were determined by regulatory influences of the host, rather than by decreased count of stromal precursor cells in the tissue.
Gorskaya
Yu F
YF
Laboratory of Immunity Regulation, N. F. Gamaleya Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow.
Nesterenko
V G
VG
D000367:Age Factors; D000818:Animals; D002452:Cell Count; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000166:cytology / Q000637:transplantation*; D013234:Stem Cells / Q000166:cytology*; D017154:Stromal Cells / Q000166:cytology