Idesolide: a new spiro compound from Idesia polycarpa.
[structure: see text]. Idesolide, a new spiro compound possessing tetrahydrobenzodioxole structure, was isolated from the fruits of Idesia polycarpa Maxim. Its structure was established by NMR and MS spectroscopic analysis with single-crystal X-ray experiments. Idesolide significantly reduced nitric oxide production induced by lipopolysaccharide in BV2 microglial cells.
Kim
Seung Hyun
SH
College of Pharmacy, Seoul National University, Kwanak-Gu, Korea.
Sung
Sang Hyun
SH
Choi
Soo Young
SY
Chung
Young Keun
YK
Kim
Jinwoong
J
Kim
Young Choong
YC
D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D005638:Fruit / Q000737:chemistry; D008070:Lipopolysaccharides / Q000494:pharmacology; D013058:Mass Spectrometry; D008968:Molecular Conformation; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D031308:Salicaceae / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D013141:Spiro Compounds; C510160:idesolide; D009569:Nitric Oxide