Ligands with dual vitamin D3-agonistic and androgen-antagonistic activities.
Ligands possessing dual vitamin D3-agonistic (estimated as HL-60 monocytic cell differentiation induction) and androgen-antagonistic (estimated as testosterone-induced SC-3 cell growth inhibition) activities with various activity spectra were prepared based on a substituted bis-phenylmethane skeleton. Some of them were revealed to be potent androgen antagonists with a nonsecosteroidal vitamin D3 skeleton.
Hosoda
Shinnosuke
S
Institute of Molecular & Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Tanatani
Aya
A
Wakabayashi
Ken-ichi
K
Nakano
Yusuke
Y
Miyachi
Hiroyuki
H
Nagasawa
Kazuo
K
Hashimoto
Yuichi
Y
D000726:Androgen Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002762:Cholecalciferol / Q000819:agonists*; D004305:Dose-Response Relationship, Drug; D018922:HL-60 Cells; D006801:Humans; D008024:Ligands; D013329:Structure-Activity Relationship; D013739:Testosterone / Q000494:pharmacology
D000726:Androgen Antagonists; D000970:Antineoplastic Agents; D001555:Benzene Derivatives; D008024:Ligands; D002762:Cholecalciferol; D013739:Testosterone