title: Network motifs are enriched with transcription factors whose transcripts have short half-lives.
abstract: Network motifs, the recurring regulatory structural patterns in networks, can self-organize to produce networks because of the large ratio of genes to transcription factors (TFs) in genomes. We find a common design principle of these motifs: the TFs whose transcripts have short half-lives are significantly enriched in motifs and hubs. This enrichment becomes one of the driving forces for the emergence of the network scale-free topology, enables the network to adapt quickly to environmental changes and mitigates gene expression fluctuations. Motifs are classified into subtypes that are preferentially used in different cellular conditions.
authors: Biotechnology Research Institute, National Research Council Canada, Montreal, Quebec, Canada H4P 2R2. Edwin.Wang@cnrc-nrc.gc.ca
authors: Edwin
authors: E
authors: Wang
authors: Enrico
authors: E
authors: Purisima
mesh_terms: D020816:Amino Acid Motifs; D004926:Escherichia coli / Q000235:genetics; D008954:Models, Biological; D014157:Transcription Factors / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D014157:Transcription Factors