title: Gastric angiodysplasia in a child with Bernard-Soulier syndrome: efficacy of octreotide in long-term management.
abstract: Gastrointestinal angiodysplasia in association with Bernard-Soulier syndrome has been previously described in adults. The authors report on a 14year-old boy presenting with massive upper gastrointestinal bleeding due to a large gastric angiodysplasia, in whom medical history and laboratory investigations were consistent with Bernard-Soulier syndrome. The vascular lesion was so widespread that surgical or endoscopic therapy was not considered. Therefore, treatment with octreotide, a somatostatin analog, was commenced, following a short course of tranexamic acid and proton pump inhibitor. During the 16-month follow-up with octreotide therapy, no occult or gross bleeding occurred. This case illustrates the utility of using octreotide for the long-term treatment of children with bleeding disorders and angiodysplasia.
authors: Department of Pediatrics, Faculty of Medicine, Gazi University, Besevler, Ankara, Turkey.
authors: Zühre
authors: Z
authors: Kaya
authors: Türkiz
authors: T
authors: Gürsel
authors: Buket
authors: B
authors: Dalgic
authors: Deniz
authors: D
authors: Aslan
mesh_terms: D000293:Adolescent; D016888:Angiodysplasia / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D001606:Bernard-Soulier Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D016099:Endoscopy, Gastrointestinal; D006801:Humans; D008297:Male; D015282:Octreotide / Q000008:administration & dosage / Q000627:therapeutic use*; D013272:Stomach Diseases / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015282:Octreotide