[P-glycoprotein expression in radiation-associated acute myeloid leukemia].
The article presents findings of the analysis on P-glycoprotein expression of leukemic cells in 52 acute myeloid leukemia (AML) patients. Of these, there were 20 persons exposed to ionizing radiation due to the Chernobyl accident and 32 patients with spontaneous disease. Leukemic cells in patients with radiation-associated AML compared to spontaneous cases more often were P-glycoprotein positive (12/20 vs 9/32, P<0,05). P-glycoprotein overexpression significantly correlated with resistant disease in patients with radiation-associated AML, but was not a prognostic variable for treatment outcome in terms of overall survival.
Bebeshko
V H
VH
Bazyka
D A
DA
Klymenko
S V
SV
Maznichenko
O L
OL
Holiarnik
N A
NA
Liaskovs'ka
O V
OV
Il'ienko
I M
IM
Tretiak
N M
NM
Vdovtsov
O O
OO
Serbinenko
T M
TM
Zubryts'ka
T B
TB
Zinchenko
V N
VN
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000096:biosynthesis*; D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001854:Bone Marrow Cells / Q000378:metabolism; D047852:Chernobyl Nuclear Accident; D005260:Female; D005434:Flow Cytometry; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood / Q000378:metabolism* / Q000401:mortality; D007953:Leukemia, Radiation-Induced / Q000097:blood / Q000378:metabolism* / Q000401:mortality; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D016019:Survival Analysis; D014455:Ukraine
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1