title: Genetic prothrombotic risk factors in women with unexplained pregnancy loss.
abstract: BACKGROUND
  Inherited thrombophilia has been associated with unexplained recurrent pregnancy loss (RPL) and stillbirth. This thrombotic tendency can manifest as thrombotic lesions in the placenta, and may lead to abortion and stillbirth. The aim of our case-control study was to investigate the prevalence of FVL and FII G20210A in women with adverse pregnancy outcome, compared to the prevalence of the same mutations in our health control group.
  
  
  METHODS
  102 consecutive women with unexplained pregnancy loss (55 with history of RPL, and 47 with history of stillbirth) were studied for hereditary thrombophilia. The health control group consisted of 217 healthy women from the general population.
  
  
  CONCLUSIONS
  Of the 55 women with recurrent abortions, we found the same prevalence for the FVL and the FII G20210A(9.1%, 5 pts). (p=NS compared to control group). Of the 47 women with stillbirth, 11 (23.4%) had the FVL and 9 (19.1%) had the FII G20210A(p<0.0005 for both mutations). In our experience the prevalence of FVL and the FII G20210Amutations was significantly higher in women with unexplained stillbirth, instead the prevalence of genetic thrombophilia was high but not statistically significant in women with recurrent pregnancy loss.
authors: Centro Emofilia-Servizio Emostasi e Trombosi, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria, Italy. giasotti@tin.it
authors: Gianluca
authors: G
authors: Sottilotta
authors: Vincenzo
authors: V
authors: Oriana
authors: Caterina
authors: C
authors: Latella
authors: Francesca
authors: F
authors: Luise
authors: Angela
authors: A
authors: Piromalli
authors: Francesca
authors: F
authors: Ramirez
authors: Corrado
authors: C
authors: Mammì
authors: Rita
authors: R
authors: Santoro
authors: Piergiorgio
authors: P
authors: Iannaccaro
authors: Gaetano
authors: G
authors: Muleo
authors: Vincenzo Trapani
authors: VT
authors: Lombardo
mesh_terms: D000026:Abortion, Habitual / Q000453:epidemiology / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics; D005260:Female; D006801:Humans; D009154:Mutation; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology / Q000235:genetics*; D015995:Prevalence; D011516:Prothrombin / Q000235:genetics*; D012189:Retrospective Studies; D012307:Risk Factors; D050497:Stillbirth; D019851:Thrombophilia / Q000150:complications* / Q000235:genetics*
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin