From the margins of the genome: mobile elements shape primate evolution.
As is the case with mammals in general, primate genomes are inundated with repetitive sequence. Although much of this repetitive content consists of "molecular fossils" inherited from early mammalian ancestors, a significant portion of this material comprises active mobile element lineages. Despite indications that these elements played a major role in shaping the architecture of the genome, there remain many unanswered questions surrounding the nature of the host-element relationship. Here we review advances in our understanding of the host-mobile element dynamic and its overall impact on primate evolution.
Hedges
Dale J
DJ
Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, LA 70803, USA.
Batzer
Mark A
MA
D017398:Alternative Splicing; D000818:Animals; D005075:Biological Evolution; D018899:CpG Islands; D019175:DNA Methylation; D019143:Evolution, Molecular; D005091:Exons; D016678:Genome; D015894:Genome, Human; D018095:Germ-Line Mutation; D006801:Humans; D020084:Long Interspersed Nucleotide Elements; D008957:Models, Genetic; D016366:Open Reading Frames; D010802:Phylogeny; D011323:Primates; D012091:Repetitive Sequences, Nucleic Acid; D012190:Retroviridae / Q000235:genetics; D020086:Short Interspersed Nucleotide Elements