title: Malignant thymoma associated with mixed connective tissue disease: a case report.
abstract: Many autoimmune diseases have been reported to be associated with malignancy. Mixed connective tissue disease (MCTD), however, has rarely been associated with malignancy. Thymoma is one of the neoplasms often reported to be related to various immunological disorders. Among the types of thymoma defined by WHO, malignant thymoma (thymoma type C) is the one least reported to be associated with autoimmune disease. Here, we report a case of malignant thymoma with concurrent MCTD, which manifested with acrosclerosis, Raynaud's phenomenon, arthritis (synovitis), and a high titer of anti-ribonucleoprotein antibody.
authors: Department of Internal Medicine, Rheumatology Unit, Kaohsiung Medical University Hospital, Kaohsiung City 807, Taiwan, ROC.
authors: Yu-Chih
authors: YC
authors: Lin
authors: Chen-Ching
authors: CC
authors: Wu
authors: Tsan-Teng
authors: TT
authors: Ou
authors: Jeng-Hsien
authors: JH
authors: Yen
authors: Hong-Wen
authors: HW
authors: Liu
authors: Wen-Chan
authors: WC
authors: Tsai
mesh_terms: D005260:Female; D006801:Humans; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000150:complications*; D013945:Thymoma / Q000150:complications*; D013953:Thymus Neoplasms / Q000150:complications*