title: Antinuclear antibodies in domestic animals.
abstract: Antinuclear antibodies in domestic animal species have been commonly detected for many years, with the greatest frequency occurring in dogs as well as horses and cats. Most commonly, the assay used in diagnostic laboratories is indirect immunofluorescence on HEP-2 cells, similar to that used in human medicine, but with the exception that species-specific antiglobulin reagents are used instead of antihuman immunoglobulin. To a lesser extent, the Crithidia luciliae test for antibodies to double-stranded DNA has been used. Several research groups have used other assays.
authors: Department of Pathology, Microbiology, and Immunology, 2019 Haring Hall, School of Veterinary Medicine, University of California, Davis, CA 95616, USA. ljgershwin@ucdavis.edu
authors: Laurel J
authors: LJ
authors: Gershwin
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear / Q000032:analysis*; D002415:Cats; D045744:Cell Line, Tumor; D003176:Complement C3 / Q000276:immunology; D003421:Crithidia / Q000276:immunology; D004247:DNA / Q000276:immunology; D004285:Dogs; D018397:Equidae; D019793:Fluorescein; D019085:Fluorescent Antibody Technique, Direct; D019084:Fluorescent Antibody Technique, Indirect; D007074:Immunoglobulin G / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D013045:Species Specificity
chemical_list: D000974:Antibodies, Antinuclear; D003176:Complement C3; D007074:Immunoglobulin G; D004247:DNA; D019793:Fluorescein