[A correlate analysis of UV absorption spectra of compound danshen tablets from different manufactures].
OBJECTIVE
To evaluate the value of UV absorption spectrum for identification and quality control of compound Danshen tablets and pills.


METHODS
UV absorption spectra of compound Danshen tablets and pills, and other drugs were scanned using ultraviolet spectrophotometer (water as the solvent). Pearson's correlation coefficients (Pearson's R) were displayed in the correlations table obtained from SPSS correlate, and deltaR defined as the absolute value of the difference between Pearson's R and its mirror image in the table were used for measuring the spectral similarity between two drugs from different manufacturers.


RESULTS
Regarding compound Danshen tablets and pills, the spectral similarity between different batch drugs from same manufacturer was very high with Pearson's R = 0.995-0.9999, and the similarity between two manufactures was high with Pearson's R = 0.92-0.997 and deltaR < 0.02. Compared with the spectra of compound Danshen tablets and pills, the spectral similarity of the other drugs was low with Pearson's R = 0.25-0.98 and deltaR > 0.02.


CONCLUSIONS
The results showed that UV absorption spectrum could be suitable for identification and quality control of compound Danshen tablets and pills.
Mo
Zhi-jiang
ZJ
The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China.
Zhang
Li-juan
LJ
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification; D010946:Plants, Medicinal / Q000737:chemistry; D011786:Quality Control; D027561:Salvia miltiorrhiza / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013607:Tablets
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D013607:Tablets