title: Inclusion of a photosensitizer in liposomes formed by DMPC/gemini surfactant: correlation between physicochemical and biological features of the complexes.
abstract: Mixed cationic liposomes composed by different ratios of dimyristoyl-sn-glycero-phosphatidylcoline (DMPC) and a cationic gemini surfactant have been studied by various physicochemical tools as vehicles for m-tetrahydroxyphenylchlorin (m-THPC), a photosensitizer used in photodynamic therapy. Entrapment and location of m-THPC within the lipid double layer have been evaluated by different techniques and the new formulations have been tested on a stabilized cell line from a human colon tumor, COLO206. A correlation between the physicochemical features of formulations and their efficiency as photosensitizers vector was found.
authors: CNR Istituto di Metodologie Chimiche-Sezione Meccanismi di Reazione, and Dipartimento di Chimica, Università degli Studi di Roma "La Sapienza", P.le A. Moro 5, I-00185 Roma, Italy.
authors: Cecilia
authors: C
authors: Bombelli
authors: Giulio
authors: G
authors: Caracciolo
authors: Pietro
authors: P
authors: Di Profio
authors: Marco
authors: M
authors: Diociaiuti
authors: Paola
authors: P
authors: Luciani
authors: Giovanna
authors: G
authors: Mancini
authors: Claudia
authors: C
authors: Mazzuca
authors: Manuela
authors: M
authors: Marra
authors: Agnese
authors: A
authors: Molinari
authors: Donato
authors: D
authors: Monti
authors: Laura
authors: L
authors: Toccacieli
authors: Mariano
authors: M
authors: Venanzi
mesh_terms: D002412:Cations; D045744:Cell Line, Tumor; D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry*; D005453:Fluorescence; D006801:Humans; D008027:Light; D008081:Liposomes / Q000737:chemistry*; D008652:Mesoporphyrins / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D018613:Microscopy, Confocal; D046529:Microscopy, Electron, Transmission; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D012542:Scattering, Radiation; D013386:Succinates / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry*; D044366:Transition Temperature
chemical_list: C502986:2,3-bis((dimethyl(pentadecyl)ammonio)methyl)succinic acid; D002412:Cations; D008081:Liposomes; D008652:Mesoporphyrins; D017319:Photosensitizing Agents; D000644:Quaternary Ammonium Compounds; D013386:Succinates; D013501:Surface-Active Agents; C072269:temoporfin; D004134:Dimyristoylphosphatidylcholine