[Alprostan for management of critical lower limb ischemia].
A clinical trial on Alprostan (prostaglandin E1) use for management of critical lower limb ischemia (Fontaine-Pokrovsky stages III and IV of chronic limb ischemia) was carried out in A. V. Vishnevsky Institute of Surgery from March, 2003 till April, 2004. The study aimed at appraisal of Alprostan effectiveness (administered alone or combined with reconstructive interventions) in coping with critical ischemia in patients with lower limb arterial occlusive lesions.
Pokrovskiĭ
A V
AV
Dan
V N
VN
Chupin
A V
AV
Kalinin
A A
AA
D000527:Alprostadil / Q000008:administration & dosage / Q000627:therapeutic use*; D002908:Chronic Disease; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007511:Ischemia / Q000188:drug therapy* / Q000503:physiopathology* / Q000601:surgery; D035002:Lower Extremity / Q000098:blood supply* / Q000503:physiopathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D014656:Vascular Surgical Procedures; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*
D014665:Vasodilator Agents; D000527:Alprostadil