Sensitive and fast T1 mapping based on two inversion recovery images and a reference image.
We developed a fast method to obtain T1 relaxation maps in magnetic resonance imaging (MRI) based on two inversion recovery acquisitions and a reference acquisition, while maintaining high sensitivity by utilizing the full dynamic range of the MRI signal. Optimal inversion times for estimating T1 in the human brain were predicted using standard error propagation theory. In vivo measurements on nine healthy volunteers yielded T1 values of 1094+/-18 ms in gray matter and 746+/-40 ms in white matter, in reasonable agreement with literature values using conventional approaches. The proposed method should be useful for clinical studies because the T1 maps can be obtained within a few seconds.
Jahng
Geon-Ho
GH
University of California-San Francisco, 4150 Clement Street, 114M San Francisco, California 94121, USA. ghjahng@itsa.ucsf.edu
Stables
Lara
L
Ebel
Andreas
A
Matson
Gerald B
GB
Meyerhoff
Dieter J
DJ
Weiner
Michael W
MW
Schuff
Norbert
N
D000465:Algorithms; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015233:Models, Statistical; D011859:Radiography; D012680:Sensitivity and Specificity