Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites.
Glenn
Matthew P
MP
Department of Chemistry, Yale University, 225 Prospect St., New Haven, CT 06511, USA.
Chang
Sung-Youn
SY
Hucke
Oliver
O
Verlinde
Christophe L M J
CL
Rivas
Kasey
K
Hornéy
Carrie
C
Yokoyama
Kohei
K
Buckner
Frederick S
FS
Pendyala
Prakash R
PR
Chakrabarti
Debopam
D
Gelb
Michael
M
Van Voorhis
Wesley C
WC
Sebti
Saïd M
SM
Hamilton
Andrew D
AD
D000284:Administration, Oral; D000813:Anilides / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D001665:Binding Sites; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D051231:Farnesyltranstransferase / Q000037:antagonists & inhibitors*; D008099:Liver / Q000187:drug effects; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism; D008958:Models, Molecular; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development*; D051381:Rats; D013329:Structure-Activity Relationship; D013997:Time Factors
D000813:Anilides; D000962:Antimalarials; D004791:Enzyme Inhibitors; D051231:Farnesyltranstransferase