title: Effects of the ovulatory serum concentration of human chorionic gonadotropin on the incidence of ovarian hyperstimulation syndrome and success rates for in vitro fertilization.
abstract: OBJECTIVE
  To determine whether the serum concentration of hCG on the day after hCG administration (abbreviated throughout this article as [hCG]) is related to the incidence of ovarian hyperstimulation syndrome (OHSS), oocyte recovery per follicle, fertilization, blastulation, embryo transfer, implantation, and clinical pregnancy.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Private infertility clinic.
  
  
  METHODS
  The OHSS study group included 849 non-donor IVF cycles performed between January 1998 and August 2003. The study group for hCG efficacy included 248 nondonor IVF cycles performed between January 2001 and May 2003 with patients younger than 35 years of age.
  
  
  METHODS
  None.
  
  
  METHODS
  Occurrence of OHSS, severity of OHSS, [hCG], proportion of follicles yielding oocytes, fertilization rate, blastulation rate, transfer rate, implantation rate, and clinical pregnancy rate.
  
  
  RESULTS
  No significant relationships were observed between [hCG] and the proportion of follicles yielding oocytes, fertilization rate, blastulation rate, or the probabilities of embryo transfer, implantation, or clinical pregnancy. The incidence of OHSS (all types) and OHSS requiring transvaginal paracentesis were predicted by [hCG] (P=.02 and P=.05, respectively) and with follicle count (P<.0001 in both cases).
  
  
  CONCLUSIONS
  These results suggest that moderated hCG dosage is useful in preventing OHSS without reducing efficacy.
authors: Fertility Center of Las Vegas, Las Vegas, Nevada, USA. bsshapiro@aol.com
authors: Bruce S
authors: BS
authors: Shapiro
authors: Said T
authors: ST
authors: Daneshmand
authors: Forest C
authors: FC
authors: Garner
authors: Martha
authors: M
authors: Aguirre
authors: Richard
authors: R
authors: Ross
authors: Suzanne
authors: S
authors: Morris
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D006063:Chorionic Gonadotropin / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D016471:Ovarian Hyperstimulation Syndrome / Q000097:blood* / Q000453:epidemiology*; D010053:Ovary / Q000378:metabolism; D010062:Ovulation Induction / Q000379:methods / Q000706:statistics & numerical data*; D011247:Pregnancy; D012189:Retrospective Studies; D018709:Statistics, Nonparametric
chemical_list: D006063:Chorionic Gonadotropin