title: Aspects of the humoral and cellular immune response in hepatitis associated with cholelithiasis.
abstract: OBJECTIVE
  To investigate the immunological reactions of the liver in various gall bladder disease.
  
  
  METHODS
  IgG, IgA and IgM were measured in the blood and bile of patients with cholecystectomy. Immunofluorescence and electron microscopy techniques were used.
  
  
  RESULTS
  The tests showed high blood values of immunoglobulins and their presence in the bile. The immunofluorescence was positive for IgG in the hepatic sinusoids. The electron microscopy showed aspects of "cellular cooperation".
  
  
  CONCLUSIONS
  On the basis of our results we can affirm that in cholelithiasis there exists an immune response to the persistent antigens, with the release of circulating immune complexes.
authors: Gr.T. Popa University of Medicine and Pharmacy, Iaşi School of Medicine, Department of Pathology.
authors: Maria Elisabeta
authors: ME
authors: Bădescu
authors: Manuela
authors: M
authors: Stancu
authors: G I
authors: GI
authors: Pandele
authors: C
authors: C
authors: Cotuţiu
authors: Cornelia
authors: C
authors: Amălinei
authors: Raluca
authors: R
authors: Balan
mesh_terms: D001646:Bile / Q000276:immunology; D002769:Cholelithiasis / Q000150:complications* / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006505:Hepatitis / Q000150:complications* / Q000276:immunology*; D022781:Hepatocytes / Q000648:ultrastructure; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008854:Microscopy, Electron
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M