IgE and Fc{epsilon}RI regulation.
A central feature of allergic reactions is the aggregation of the high-affinity IgE receptor, FcepsilonRI, to initiate a change in the behavior of the cell expressing the receptor. It is now clear that a number of cell types can express this receptor, which broadens the biology that revolves around IgE antibody. It is also quite clear that the presence of monomeric IgE antibody alters the expression of FcepsilonRI. There remains considerable uncertainty about the importance of independent regulation of the FcepsilonRIbeta subunit or its splice variant beta(T), in terms of regulating both expression and function of FcepsilonRI. There is also only primitive understanding of the role of various polymorphisms in the subunit genes on the atopic phenotype. There are, however, many efforts being made to resolve these issues and to discover other factors that regulate expression of this receptor. Of particular interest for understanding the variation in expression in atopy among patients, the role of this receptor on non-mast cell/basophils will be important to elucidate.
Macglashan
Donald
D
The Johns Hopkins Asthma and Allergy Center, 5501 Bayview Circle, Baltimore, MD 21224, USA. dmacglas@jhmi.edu
D017398:Alternative Splicing; D000818:Animals; D001491:Basophils / Q000276:immunology; D003876:Dermatitis, Atopic / Q000235:genetics / Q000276:immunology; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology*; D018448:Models, Immunological; D011110:Polymorphism, Genetic; D017455:Receptors, IgE / Q000097:blood / Q000235:genetics* / Q000276:immunology*
D017455:Receptors, IgE; D007073:Immunoglobulin E