[Preliminary study on genotype of hepatitis B virus detected from Tibetans in China].
OBJECTIVE
To determine the main genotype of hepatitis B virus (HBV) detected from Tibetans in China and provide basic data for hepatitis control and prevention.


METHODS
The S gene and C gene were amplified by PCR from the sera of HBsAg positive Tibetans. After sequencing, the gene sequences were analyzed and the phylogenetic trees were drawn by the software MEGA3.


RESULTS
In trees based on S gene, the sequences of most samples clustered at genotype D, while in trees based on C gene, the sequences of all samples clustered at genotype C.


CONCLUSIONS
The dominant genotype of HBV detected from Tibetans in China is a C/D hybrid.
Xu
Yan-qing
YQ
Department of Hepatitis Virus, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China.
Zhou
Yong-dong
YD
Bi
Sheng-li
SL
D005838:Genotype; D006509:Hepatitis B / Q000097:blood / Q000453:epidemiology / Q000821:virology*; D006512:Hepatitis B Core Antigens / Q000235:genetics; D006514:Hepatitis B Surface Antigens / Q000097:blood / Q000235:genetics; D006515:Hepatitis B virus / Q000145:classification / Q000235:genetics* / Q000276:immunology; D006801:Humans; D010802:Phylogeny; D018609:Tibet / Q000453:epidemiology
D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens