Case reports: treatment of nevirapine-associated dress syndrome with intravenous immune globulin (IVIG).
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is an adverse drug reaction most commonly associated with aromatic antiepileptic agents. It is characterized by the triad of skin eruption, fever, and systemic involvement, with the latter usually manifesting as hepatitis and lymphadenopathy. Mortality is primarily due to hepatic failure and can be as high as 10%. Formerly referred to by names such as Dilantin hypersensitivity syndrome and anticonvulsant hypersensitivity syndrome, DRESS syndrome is a more precise term since this reaction pattern can be seen with other agents. DRESS syndrome has also been reported in association with sulfonamides, allopurinol, terbinafine, minocycline, azathioprine, and dapsone as well as with several antiretroviral agents such as abacavir and nevirapine. We describe a patient with HIV who developed nevirapine hypersensitivity syndrome who was successfully treated with intravenous immune globulin (IVIG).
Fields
Katherine S
KS
Department of Dermatology, University of Utah, School of Medicne, Salt Lake City, UT 84132-2409, USA. katherine.fields@hsc.utah.edu
Petersen
Marta J
MJ
Chiao
Elizabeth
E
Tristani-Firouzi
Payam
P
D000328:Adult; D004802:Eosinophilia / Q000139:chemically induced* / Q000188:drug therapy; D005076:Exanthema / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008297:Male; D019829:Nevirapine / Q000009:adverse effects*; D013577:Syndrome
D016756:Immunoglobulins, Intravenous; D019829:Nevirapine