[Influence of trauma-hemorrhagic shock on endotoxin, tumor necrosis factor-alpha and interleukin-6 levels in mesenteric lymph and blood of rats].
OBJECTIVE
To investigate the influence of trauma-hemorrhagic shock on endotoxin (ET), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) levels in mesenteric lymph and blood of rats.


METHODS
Mesenteric lymph from trauma-hemorrhagic shock rats were collected, levels of ET, TNF-alpha and IL-6 in mesenteric lymph were compared with those from blood samples.


RESULTS
Levels of ET, TNF-alpha and IL-6 in mesenteric lymph were elevated during shock period (all P<0.05), and they were decreased to normal range after resuscitation, with an exception of high IL-6 level up to 2 hours following resuscitation.


CONCLUSIONS
The bacterial translocation could occur during shock period via lymphatic pathway, thereby leading to the increase in TNF-alpha and IL-6 levels, as well as systemic inflammatory response syndrome.
Gu
Bao-chun
BC
Department of General Surgery, Nanfang Hospital, Nanfang Medical University, Guangzhou 510015, Guangdong, China.
Liu
Zheng-jun
ZJ
Shi
Han-ping
HP
Liu
Liang-ming
LM
D000818:Animals; D004195:Disease Models, Animal; D004731:Endotoxins / Q000097:blood / Q000378:metabolism*; D015850:Interleukin-6 / Q000097:blood / Q000378:metabolism*; D008196:Lymph / Q000378:metabolism; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012774:Shock, Traumatic / Q000097:blood / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000378:metabolism*
D004731:Endotoxins; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha