A prospective, randomized and blinded comparison between 10,000 IU urinary and 250 microg recombinant human chorionic gonadotropin for oocyte maturation in in vitro fertilization cycles.
OBJECTIVE
To compare the efficacy and safety of u-hCG with r-hCG in IVF cycles.


METHODS
A prospective, investigator-blind, randomized, comparative study. Patients (n = 100) < or =35 years with IVF indication were randomly assigned on the day of hCG administration for oocyte maturation to receive either u-hCG (10,000 IU) or r-hCG (250 microg).


RESULTS
No statistical differences were found between groups in relation to total number of oocytes retrieved, percentage of mature oocytes, number of injected oocytes, fertilization rates and number of embryos transferred. The data indicate a possible trend toward a higher incidence of pregnancy in the r-hCG group. Adverse events, predominantly injection-site reactions, were significantly more common in the u-hCG group.


CONCLUSIONS
r-hCG is at least as effective for inducing final stages of oocyte maturation as 10,000 IU u-hCG and is also associated with significantly better patient tolerance and thus higher patient acceptability.
Abdelmassih
Vicente
V
Clinica e Centro de Pesquisa em Reprodução Humana Roger Abdelmassih, Av. Brasil, 1085, São Paulo, SP, CEP. clinicavida@terra.com.br
Oliveira
Flavio G
FG
Goncalves
Sergio P
SP
Varella
Adriana D
AD
Diamond
Michael P
MP
Abdelmassih
Roger
R
D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D009865:Oocytes / Q000254:growth & development*; D011446:Prospective Studies; D011994:Recombinant Proteins; D016037:Single-Blind Method
D006063:Chorionic Gonadotropin; D011994:Recombinant Proteins