[Effects of Huatan Xiezhuo Recipe on insulin resistance and leptin in rats with fatty liver].
OBJECTIVE
To observe the effects of Huatan Xiezhuo Recipe (HTXZR) on fatty liver of rats.


METHODS
Forty-eight SD rats were randomly divided into five groups: normal control group, untreated group, Dongbao Gantai Tablet (DBGTT)-treated group, low-dose HTXZR-treated group and high-dose HTXZR-treated group. Fatty liver was induced in the rats by hyperlipid diet and intraperitoneal injection of tetracycline. The pathological changes of liver tissues in rats were observed, and the liver function, serum leptin, insulin resistance index, triglyceride (TG) and free fatty acid (FFA) in the liver were detected.


RESULTS
The levels of serum leptin, insulin resistance index, FFA and TG in rats of the three treated groups were lower than those of the untreated group (P<0.01), and such effects in the HTXZR-treated groups were more significant than those in the DBGTT-treated group (P<0.05).


CONCLUSIONS
The main action mechanisms of HTXZR in treating fatty liver are probably to promote the lipid metabolism, decrease the leptin and insulin resistance.
Ye
Fang
F
First Clinical College, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu Province 210029, China.
Zhao
Wen-Xia
WX
Miao
Ming-San
MS
Li
Jian-Guo
JG
Zhang
Yong-Yan
YY
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005234:Fatty Liver / Q000188:drug therapy* / Q000378:metabolism; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D008297:Male; D008517:Phytotherapy; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal; D005230:Fatty Acids, Nonesterified; D020738:Leptin