Influence of sodium benzoate on the metabolism of o-xylene in the rat.
The main metabolites of o-xylene in urine are o-methylhippuric acid, o-toluic acid, o-toluic acid glucuronide, 3,4-dimethylphenol, 3,4-dimethylphenol conjugates and o-xylylmercapturic acid. The urinary excretion of o-toluic acid, o-toluic acid conjugates and o-xylene were increased by the prior administration of sodium benzoate. Conversely, the amounts of o-methylhippuric acid, 3,4-dimethylphenol conjugates and o-xylylmercapturic acid decreased by sodium benzoate pretreatment. In addition, the urinary excretion of o-methylhippuric acid was delayed by the pretreatment. The percentages of urinary excretion of the o-xylene metabolites were substantially changed by the pretreatment with sodium benzoate. These results therefore highlight a potential interaction of an air pollutant with a food additive, an interaction that remains to be established in man.
Moriwaki
H
H
Osaka City Institute of Public Health and Environmental Sciences, Osaka, Japan.
Tsujimoto
Y
Y
Shimizu
M
M
Noda
T
T
Warashina
M
M
Tanaka
M
M
D000818:Animals; D001711:Biotransformation; D008297:Male; D008958:Models, Molecular; D015394:Molecular Structure; D051381:Rats; D017208:Rats, Wistar; D020160:Sodium Benzoate / Q000494:pharmacology*; D014992:Xylenes / Q000737:chemistry / Q000493:pharmacokinetics*
D014992:Xylenes; D020160:Sodium Benzoate; C026114:2-xylene