TLR8 and TLR7 are involved in the host's immune response to human parechovirus 1.
Toll-like receptors (TLR) have a key role in regulating immunity against microbial agents. Engagement of TLR by bacterial, viral or fungal components leads to the production and release of inflammatory cytokines. In this study we show that mainly TLR8 and also TLR7 act as the host sensors for human parechovirus 1, a single-stranded RNA (ssRNA) virus. Furthermore, we see that the viral ssRNA genome is detected in endosomal compartments by these TLR, which activate signalling that lead to the synthesis of pro-inflammatory molecules by the host.
Triantafilou
Kathy
K
University of Sussex, Infection and Immunity group, School of Life Sciences, Brighton, UK. M.Triantafilou@sussex.ac.uk
Vakakis
Emmanouil
E
Orthopoulos
George
G
Ahmed
Mohamed Abd Elrahman
MA
Schumann
Christian
C
Lepper
Philipp M
PM
Triantafilou
Martha
M
D000328:Adult; D002460:Cell Line; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism; D011992:Endosomes / Q000378:metabolism; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000502:physiology*; D030061:Parechovirus / Q000235:genetics / Q000276:immunology*; D010850:Picornaviridae Infections / Q000276:immunology* / Q000378:metabolism; D012367:RNA, Viral / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology*; D020545:Respiratory Mucosa / Q000276:immunology / Q000378:metabolism / Q000821:virology; D015398:Signal Transduction / Q000276:immunology; D051199:Toll-Like Receptor 7; D051200:Toll-Like Receptor 8; D051193:Toll-Like Receptors
D016207:Cytokines; D008562:Membrane Glycoproteins; D012367:RNA, Viral; D011956:Receptors, Cell Surface; C495348:TLR7 protein, human; C495349:TLR8 protein, human; D051199:Toll-Like Receptor 7; D051200:Toll-Like Receptor 8; D051193:Toll-Like Receptors