The pharmacogenetics of coumarin therapy.
Vitamin K antagonists (coumarins) are widely-used oral anticoagulants for the prevention of venous thromboembolism and strokes. Wide inter-individual variation in dose response and frequent bleeds characterize the initiation of coumarin therapy. Over the past 10 years both genetic and nongenetic determinants of coumarin dose response have been identified. A comprehensive pharmacogenetics approach to warfarin therapy has the potential to improve the safety and efficiency of warfarin initiation.
Voora
Deepak
D
Washington University School of Medicine, Departments of Medicine and of Pathology, St. Louis, MO 63110, USA.
McLeod
Howard L
HL
Eby
Charles
C
Gage
Brian F
BF
D000925:Anticoagulants / Q000494:pharmacology / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000187:drug effects; D003374:Coumarins / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008954:Models, Biological; D010597:Pharmacogenetics; D020521:Stroke / Q000517:prevention & control; D020246:Venous Thrombosis / Q000517:prevention & control; D014859:Warfarin / Q000494:pharmacology / Q000627:therapeutic use
D000925:Anticoagulants; D003374:Coumarins; D014859:Warfarin