[In vitro maturation and fertilization of oocytes from unstimulated cycles in women with infertility due to polycystic ovary syndrome].
OBJECTIVE
To investigate the effect of in vitro maturation (IVM) and fertilization of oocytes from unstimulated cycles in women with infertility due to polycystic ovary syndrome (PCOS).


METHODS
Seventy women with PCOS, who came to our clinic during March to were involved in this trial. June 2003. Every cycle was given human chorionic gonadotropin 10,000 IU 36 h before oocyte retrieval. Immature oocytes were matured in vitro and fertilized, and the resulting embryos were replaced back to the uterus.


RESULTS
A total of 94 IVM cycles were performed and 1283 oocytes were obtained. The overall maturation, fertilization and cleavage rates were 65.3%, 66.0% and 48.0% respectively. Maturation, fertilization, cleavage and high quality embryo rates had no difference between metaphase I stage oocytes (69.7%, 71.7%, 52.2% and 26.1% respectively) and germinal vesical (GV) stage oocytes (67.7%, 66.4%, 47.6% and 24.1% respectively), but the rates in those oocytes which could not be classified (44.8%, 53.8%, 46.2% and 16.9% respectively) were much lower than the former two groups. After embryo transfer, 18 pregnancies were reported (24%).


CONCLUSIONS
IVM/IVF-ET in unstimulated cycles is a feasible treatment for women with PCOS.
Li
Yuan
Y
Reproductive Medicine Center of Shandong Provincial Hospital, Shandong University, Jinan 250021, China.
Jiang
Jing-jing
JJ
Ma
Shui-ying
SY
Li
Mei
M
Hu
Jing-mei
JM
Zhao
Li-xin
LX
Chen
Zi-jiang
ZJ
D000328:Adult; D002478:Cells, Cultured; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy*; D054315:Oocyte Retrieval; D009865:Oocytes / Q000187:drug effects / Q000254:growth & development*; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D012102:Reproductive Control Agents / Q000008:administration & dosage; D016896:Treatment Outcome
D006063:Chorionic Gonadotropin; D012102:Reproductive Control Agents