title: Pd-catalyzed copper-free carbonylative Sonogashira reaction of aryl iodides with alkynes for the synthesis of alkynyl ketones and flavones by using water as a solvent.
abstract: The Pd-catalyzed copper-free carbonylative Sonogashira coupling reaction to synthesize alkynyl ketones from terminal alkynes and aryl iodides was achieved by using water as a solvent. The reaction was carried out at room temperature under balloon pressure of CO with Et(3)N as a base. The developed method was successfully applied to the synthesis of flavones.
authors: Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education, College of Chemistry, School of Pharmaceutical Science, ShenZhen Graduate School, Peking University, Beijing 100871, China.
authors: Bo
authors: B
authors: Liang
authors: Mengwei
authors: M
authors: Huang
authors: Zejin
authors: Z
authors: You
authors: Zhengchang
authors: Z
authors: Xiong
authors: Kui
authors: K
authors: Lu
authors: Reza
authors: R
authors: Fathi
authors: Jiahua
authors: J
authors: Chen
authors: Zhen
authors: Z
authors: Yang
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D003500:Cyclization; D047309:Flavones / Q000138:chemical synthesis*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry; D006847:Hydrocarbons, Iodinated / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D000480:Alkynes; D047309:Flavones; D006841:Hydrocarbons, Aromatic; D006847:Hydrocarbons, Iodinated; D007659:Ketones; D014867:Water; D010165:Palladium; D003300:Copper