Modulating role of NO in haloperidol-induced catalepsy.
Injection of haloperidol during catalepsy modeling decreased the content of NO in rat cerebral cortex. NO precursor L-arginine arrested catalepsy and prevented the decrease in NO content.
Narkevich
V B
VB
Laboratory of Neurochemical Pharmacology, V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow. narvik@narod.ru
Mikoyan
V D
VD
Bashkatova
V G
VG
D000818:Animals; D001120:Arginine / Q000494:pharmacology / Q000627:therapeutic use; D002375:Catalepsy / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control*; D002540:Cerebral Cortex / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D006220:Haloperidol; D009569:Nitric Oxide / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D009569:Nitric Oxide; D001120:Arginine; D006220:Haloperidol