Specific retinotopically based magnocellular impairment in a patient with medial visual dorsal stream damage.
We report here retinotopically based magnocellular deficits in a patient with a unilateral parieto-occipital lesion. We applied convergent methodologies to study his dorsal stream processing, using psychophysics as well as structural and functional imaging. Using standard perimetry we found deficits involving the periphery of the left inferior quadrant abutting the horizontal meridian, suggesting damage of dorsal retinotopic representations beyond V1. Retinotopic damage was much more extensive when probed with frequency-doubling based contrast sensitivity measurements, which isolate processing within the magnocellular pathway: sensitivity losses now encroached on the visual central representation and did not respect the horizontal meridian, suggesting further damage to dorsal stream retinotopic areas that contain full hemi-field representations, such as human V3A or V6. Functional imaging revealed normal responses of human MT+ to motion contrast. Taken together, these findings are consistent with a recent proposal of two distinct magnocellular dorsal stream pathways: a latero-dorsal pathway passing to MT+ and concerned with the processing of coherent motion, and a medio-dorsal pathway that routes information from V3A to the human homologue of V6. Anatomical evidence was consistent with sparing of the latero-dorsal pathway in our patient, and was corroborated by his normal performance in speed, direction discrimination and motion coherence tasks with 2D and 3D objects. His pattern of dysfunction suggests damage only to the medio-dorsal pathway, an inference that is consistent with structural imaging data, which revealed a lesion encompassing the right parieto-occipital sulcus.
Castelo-Branco
Miguel
M
Department of Biophysics and Center for Ophthalmology, IBILI-Faculty of Medicine, Az. de Sta Comba, 3000-354 Coimbra, Portugal. mcbranco@ibili.uc.pt
Mendes
Mafalda
M
Silva
Maria Fátima
MF
Januário
Cristina
C
Machado
Egídio
E
Pinto
Alda
A
Figueiredo
Patrícia
P
Freire
António
A
D000368:Aged; D001925:Brain Damage, Chronic / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D004192:Discrimination, Psychological; D004569:Electroencephalography; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009039:Motion Perception; D009778:Occipital Lobe / Q000473:pathology / Q000503:physiopathology; D009949:Orientation; D010296:Parietal Lobe / Q000473:pathology / Q000503:physiopathology; D010468:Perceptual Disorders / Q000209:etiology / Q000503:physiopathology*; D011601:Psychophysics; D013028:Space Perception; D014795:Visual Pathways / Q000473:pathology / Q000503:physiopathology*