[Research advance on molecular and cellular biology of small cell lung cancer].
Various genetic mutations and biologic alterations occur during cancerization, which promote the malignant development of tumors. Multiple genes are involved in and cooperated with the occurrence and development of small cell lung cancer (SCLC). SCLC manifests early and frequent metastasis as well as ultimate poor response to chemotherapy. New therapies for SCLC based on understanding of molecular and cellular mechanism of transformation are needed. SCLC is associated with multiple chromosomal abnormalities, the most common of which is chromosome 3p deletion, as well as abnormal oncogenes and tumor suppressor genes. Along with the genetic alterations, SCLC overexpresses various cell surface receptors, such as receptor tyrosine kinase (RTKs), G-protein-coupled receptors, integrins, and so on. Some activated downstream molecules, such as phosphatidylinositol 3'kinase, would serve as good candidates for therapeutic targets.
Ji
Fu-Yun
FY
Institute of Respiratory Disease, Xinqiao Hospital, The Third Military Medical University, Chongqing, 400037, PR China.
Qian
Gui-Sheng
GS
Huang
Gui-Jun
GJ
D000818:Animals; D018288:Carcinoma, Small Cell / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002869:Chromosome Aberrations; D016147:Genes, Tumor Suppressor / Q000502:physiology; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D015398:Signal Transduction; D019098:Telomerase / Q000378:metabolism
D020794:Receptor Protein-Tyrosine Kinases; D019098:Telomerase