It's HIP to be a hub: new trends for old-fashioned proteins.
Many endocytic proteins shuttle between the nucleus and the cytoplasm; however, their putative function in the nucleus is unclear. Now, new data demonstrate that huntingtin interacting protein 1 (HIP1), an endocytic protein, modulates the transcriptional activity of nuclear hormone receptors. In network theory, therefore, HIP1 can be regarded as a hub connecting heterogeneous functional "territories:" a possibility with important physiological and pathological implications.
Vecchi
Manuela
M
Fondazione Istituto FIRC (Fondazione Italiana per la Ricerca sul Cancro) di Oncologia Molecolare, 20139 Milan, Italy. pierpaolo.difiore@ifom-ieo-campus.it
Di Fiore
Pier Paolo
PP
D002467:Cell Nucleus / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004705:Endocytosis; D006801:Humans; D009154:Mutation; D019913:Nuclear Localization Signals / Q000235:genetics / Q000378:metabolism; D021381:Protein Transport; D011944:Receptors, Androgen / Q000235:genetics / Q000378:metabolism*; D020218:Response Elements; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured
D004268:DNA-Binding Proteins; C073368:HIP1 protein, human; D019913:Nuclear Localization Signals; D011944:Receptors, Androgen