[Chemistry of polysaccharide Lzps-1 from Ganoderma lucidum spore and anti-tumor activity of its total polysaccharides].
OBJECTIVE
To study the structure and anti-tumor activity of polysaccharide from Ganoderma lucidum spore treated with microwave.


METHODS
DEAE-cellulose and Sephadex G-50 column chromatography were used to isolate and purify the polysaccharide whose structure was characterized by using chemical and spectral methods.


CONCLUSIONS
One polysaccharide, named Lzps-1 was obtained from the water extract, with its molecular weight estimated by HPGPC to be 8000. Its structure was investigated to be glucan. The total polysaccharides, Lzps processed antitumor activity against sarcoma 180 and Lewis lung cancer in mice and enhanced the NK cell activity. Lzps-1 is obtained for the first time from Ganoderma spore Lzps has anti-tumor activity.
Jiang
Yan
Y
Shanghai Institute of Organic Chemistry, Shanghai 200032, China.
Wang
Hao
H
Lü
Long
L
Tian
Geng-yuan
GY
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018827:Carcinoma, Lewis Lung / Q000473:pathology; D007694:Killer Cells, Natural / Q000187:drug effects; D051379:Mice; D008970:Molecular Weight; D011134:Polysaccharides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020940:Reishi / Q000737:chemistry*; D012510:Sarcoma 180 / Q000473:pathology; D013172:Spores, Fungal / Q000737:chemistry
D000970:Antineoplastic Agents; D011134:Polysaccharides