Gouty arthritis. A primer on late-onset gout.
Gouty arthritis, a common source of pain and disability, is the most common form of inflammatory arthritis affecting older people. The authors review the epidemiology and pathogenesis of hyperuricemia and gout, as well as the clinical forms of gouty arthritis. Gout is part of a clinical spectrum of conditions (obesity, diabetes mellitus, hyperlipidemia, coronary artery disease) and need for better patient education on management of these associated conditions is emphasized. The general algorithm of gout management is presented. Clinical particularities of gout presentation in older patients (increased incidence in women, polyarticular onset with hand involvement, earlier development of tophi, association with use of diuretics) are reviewed. Barriers against an optimal control of gout include lack of patient education, presence of comorbid conditions, particularly renal impairment, use of multiple drugs such as diuretics, and cognitive decline. Gout management in older adults remains unsatisfactory.
Ene-Stroescu
Daniel
D
Internal Medicine Northwest, Tacoma, Washington, USA.
Gorbien
Martin J
MJ
D000368:Aged; D000493:Allopurinol / Q000627:therapeutic use*; D015210:Arthritis, Gouty / Q000145:classification / Q000188:drug therapy / Q000209:etiology; D005260:Female; D005853:Geriatrics; D006074:Gout Suppressants / Q000627:therapeutic use*; D006801:Humans; D033461:Hyperuricemia / Q000150:complications* / Q000453:epidemiology; D015994:Incidence; D008297:Male; D015995:Prevalence; D017678:Sex Distribution; D014481:United States / Q000453:epidemiology
D006074:Gout Suppressants; D000493:Allopurinol