title: Controversies in primary CNS lymphoma.
abstract: Primary CNS lymphoma is a non-Hodgkin's lymphoma confined to the CNS: the brain, eyes and cerebrospinal fluid. Unlike other primary brain tumors, primary CNS lymphoma is uniquely chemo- and radiosensitive. However, the outcome of primary CNS lymphoma patients is significantly inferior to similar non-Hodgkin's lymphoma patients. Multiple prospective studies using high-dose methotrexate, with or without whole-brain radiotherapy, have reported improved primary CNS lymphoma outcome, but numerous questions remain regarding the optimal care of a given patient.
authors: Department of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, NY 10021, USA. abreyl@mskcc.org
authors: Lauren E
authors: LE
authors: Abrey
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D016543:Central Nervous System Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000532:radiotherapy; D008727:Methotrexate / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D008727:Methotrexate