title: Inhibition of tumor cell proliferation by thieno[2,3-d]pyrimidin-4(1H)-one-based analogs.
abstract: On the basis of a screening lead from an assay using a pair of p21 isogenic cell lines (p21-proficient cells and p21-deficient cells) to identify chemoselective agents, a series of novel thieno[2,3-d]pyrimidin-4(1H)-one-based analogs was prepared. Some analogs inhibited the growth of human colon tumor cells.
authors: Chemical and Screening Sciences, Wyeth Research, Pearl River, NY 10965, USA. wangd@wyeth.com
authors: Yanong D
authors: YD
authors: Wang
authors: Steven
authors: S
authors: Johnson
authors: Dennis
authors: D
authors: Powell
authors: John P
authors: JP
authors: McGinnis
authors: Miriam
authors: M
authors: Miranda
authors: Sridhar K
authors: SK
authors: Rabindran
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D011744:Pyrimidinones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D011744:Pyrimidinones