Ménétrier's disease in a patient with Helicobacter pylori infection is linked to elevated glucagon-like peptide-2 activity.
This report focuses on a 59-year-old male Japanese patient with Ménétrier's disease who suffered from severe hypoproteinemia and tested positive for Helicobacter pylori when initially admitted to hospital. Blood levels of intact glucagon-like peptide-2 (GLP-2) were determined by specific bioassay, using serum-induced cAMP production in COS-7 cells expressing recombinant human GLP-2 receptors as a functional readout. Eradication of H. pylori led to remission of Ménétrier's disease as well as a partial yet significant decrease in GLP-2 levels, and also improved hypoproteinemia. These observations suggest a possible link between excess systemic endogenous production of GLP-2, a gut hormone that induces mucosal growth, and the hypertrophic gastropathy in a Ménétrier's disease patient with H. pylori infection.
Watanabe
Kazuhiro
K
Third Department of Internal Medicine, Kyorin University School of Medicine, Mitaka, Tokyo, Japan. kaz@kyorin-u.ac.jp
Beinborn
Martin
M
Nagamatsu
Shinya
S
Ishida
Hitoshi
H
Takahashi
Shin'ichi
S
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D005758:Gastritis, Hypertrophic / Q000150:complications / Q000378:metabolism*; D053767:Glucagon-Like Peptide 2; D004763:Glucagon-Like Peptides; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D064747:Lansoprazole; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000627:therapeutic use; D009853:Omeprazole / Q000031:analogs & derivatives / Q000627:therapeutic use; D010455:Peptides / Q000378:metabolism*; D012074:Remission Induction
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D053767:Glucagon-Like Peptide 2; D010455:Peptides; D064747:Lansoprazole; D004763:Glucagon-Like Peptides; D000658:Amoxicillin; D008911:Minocycline; D009853:Omeprazole