title: Spatial variation in the management and outcomes of acute coronary syndrome.
abstract: BACKGROUND
  Regional disparities in medical care and outcomes with patients suffering from an acute coronary syndrome (ACS) have been reported and raise the need to a better understanding of links between treatment, care and outcomes. Little is known about the relationship and its spatial variability between invasive cardiac procedure (ICP), hospital death (HD), length of stay (LoS) and early hospital readmission (EHR). The objectives were to describe and compare the regional rates of ICP, HD, EHR, and the average LoS after an ACS in 2000 in the province of Quebec. We also assessed whether there was a relationship between ICP and HD, LoS, and EHR, and if the relationships varied spatially.
  
  
  METHODS
  Using secondary data from a provincial hospital register, a population-based retrospective cohort of 24,544 patients hospitalized in Quebec (Canada) for an ACS in 2000 was built. ACS was defined as myocardial infarction (ICD-9: 410) or unstable angina (ICD-9: 411). ICP was defined as the presence of angiography, angioplasty or aortocoronary bypass (CCA: 480-483, 489), HD as all death cause at index hospitalization, LoS as the number of days between admission and discharge from the index hospitalization, and EHR as hospital readmission for a coronary heart disease <or=30 days after discharge from hospital. The EHR was evaluated on survivors at discharge.
  
  
  RESULTS
  ICP rate was 43.7% varying from 29.4% to 51.6% according to regions. HD rate was 6.9% (range: 3.3-8.2%), average LoS was 11.5 days (range: 7.5-14.4; median LoS: 8 days) and EHR rate was 8.3% (range: 4.7-14.2%). ICP was positively associated with LoS and negatively with HD and EHR; the relationship between ICP and LoS varied spatially. An increased distance to a specialized cardiology center was associated with a decreased likelihood of ICP, a decrease in LoS, but an increased likelihood of EHR.
  
  
  CONCLUSIONS
  The main results of this study are the regional variability of the outcomes even after accounting for age, gender, ICP and distance to a cardiology center; the significant relationships between ICP and HD, LoS and EHR, and the spatial variability in the relationships between ICP and LoS.
authors: Family Medicine Department, Faculty of Medicine, Université de Sherbrooke, 3001, 12th Avenue North, Sherbrooke (QC), Canada, J1H 5N4. alain.vanasse@usherbrooke.ca
authors: Alain
authors: A
authors: Vanasse
authors: Théophile
authors: T
authors: Niyonsenga
authors: Josiane
authors: J
authors: Courteau
authors: Jean-Pierre
authors: JP
authors: Grégoire
authors: Abbas
authors: A
authors: Hemiari
authors: Julie
authors: J
authors: Loslier
authors: Goze
authors: G
authors: Bénié
mesh_terms: D000208:Acute Disease; D000328:Adult; D000789:Angina, Unstable / Q000401:mortality / Q000628:therapy; D002300:Cardiac Care Facilities; D006348:Cardiac Surgical Procedures; D003327:Coronary Disease / Q000401:mortality / Q000628:therapy*; D005260:Female; D006297:Health Services Accessibility; D006801:Humans; D007902:Length of Stay; D008297:Male; D009203:Myocardial Infarction / Q000401:mortality / Q000628:therapy; D010359:Patient Readmission; D011792:Quebec; D012044:Regression Analysis; D012189:Retrospective Studies; D013577:Syndrome; D013997:Time Factors