Evaluation of the anti-inflammatory effect of erythromycin on aseptic inflammation of temporomandibular joint in rabbit: a scintigraphic and histopathologic study.
This article investigates the anti-inflammatory effects of erythromycin (EM) on aseptic inflammation of temporomandibular joint (TMJ) space using by Tc-99 m HIG scintigraphy and histopathology. In this experimental study, 33 adult male New Zealand White rabbits were divided into three groups. The animals in the first group were treated with EM 25 mg kg(-1); the animals in the second group were treated with methylprednisolone (MP) 2 mg kg(-1) and the animals in the third group were given saline solution (control group). Each drug was given by intraperitoneal injection twice a day for 7 days. Two hours after the last injection, carrageenan was injected into right TMJ of rabbits for aseptic inflammation. After carrageenan injection, each rabbit was given an intravenous injection of 111 Mbq (3 mCi) Tc-99 m human HIG, and scanning was performed 4 h later. Later, all animals were killed and TMJ and periarticular tissues were resected. Histopathologically, the distance between synovial surface epithelium (SSE) and muscle layer (ML) in each section was measured by using SAMBA 200 Cell image processor with software. Scintigraphically, when lesion activity/adjacent region activity (L/N) was evaluated there was a significant difference between the control group and the other two groups (P < 0.05 for EM and MP). However, no significant difference was found between the EM and MP groups. Histopathologically, the mean distance between SSE and ML in the sections was found longer in the control group (78.6 +/- 10.7 microm) than in the EM (44.38 +/- 18.26 microm) and MP (44.05. +/- 18.25 microm) groups. We think that administration of EM, which is a well-known macrolid antibiotic, might be very effective in the treatment of aseptic inflammation of TMJ space. Because corticosteroid administration has many side effects, EM may be a preferable drug in the treatment of inflammation of TMJ.
Ertaş
Umit
U
Department of Oral and Maxillofacial Surgery, School of Dentistry, Ataturk University, Erzurum, Turkey. uertas1970@yahoo.com
Tozoglu
Sinan
S
Sahin
Onder
O
Seven
Bedri
B
Gundogdu
Cemal
C
Aktan
Bulent
B
Yildirim
Mustafa
M
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001168:Arthritis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D004848:Epithelium / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology; D004917:Erythromycin / Q000008:administration & dosage / Q000627:therapeutic use*; D005152:Facial Muscles / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology; D007091:Image Processing, Computer-Assisted; D007136:Immunoglobulins; D007274:Injections, Intraperitoneal; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D011817:Rabbits; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012965:Sodium Chloride; D013583:Synovial Membrane / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology; D013667:Technetium; D013704:Temporomandibular Joint / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology; D013705:Temporomandibular Joint Disorders / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology
D000893:Anti-Inflammatory Agents; D007136:Immunoglobulins; D019275:Radiopharmaceuticals; C065376:technetium Tc 99m immunoglobulin; D012965:Sodium Chloride; D004917:Erythromycin; D013667:Technetium; D008775:Methylprednisolone