title: Moyamoya syndrome with intraventricular hemorrhage in an adult with factor V Leiden mutation.
abstract: OBJECTIVE
  To report a case of proximal occlusion of 2 major cerebral vessels associated with moyamoya network circulation that manifested by spontaneous intraventricular hemorrhage.
  
  
  METHODS
  Case report.
  
  
  RESULTS
  A 36-year-old Syrian man presented with symptoms of sudden-onset headache, neck stiffness, and confusion. The computed tomography scan of his brain showed intraventricular bleeding, and the subsequent 4 vessel angiographies revealed occlusion of the left middle and anterior cerebral arteries with moyamoya appearance in the terminal branches. The coagulation profile showed the presence of heterozygous factor V Leiden mutation. The patient was treated conservatively until resolution of his blood clot, and later he was started on oral anticoagulation.
  
  
  CONCLUSIONS
  Factor V Leiden mutation may cause large cerebral vessel occlusion with moyamoya syndrome in adults.
authors: Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon. rj04@aub.edu.lb
authors: Rosette
authors: R
authors: Jabbour
authors: Ali
authors: A
authors: Taher
authors: Ali
authors: A
authors: Shamseddine
authors: Samir F
authors: SF
authors: Atweh
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D002533:Cerebral Angiography; D005165:Factor V / Q000235:genetics*; D006801:Humans; D020300:Intracranial Hemorrhages / Q000209:etiology*; D008297:Male; D009072:Moyamoya Disease / Q000150:complications* / Q000473:pathology*; D014057:Tomography, X-Ray Computed
chemical_list: D000925:Anticoagulants; C095381:factor V Leiden; D005165:Factor V