title: A new healthy sunscreen system for human: solid lipid nanoparticles as carrier for 3,4,5-trimethoxybenzoylchitin and the improvement by adding Vitamin E.
abstract: The aim of this study was to find safer cosmetics for human through application chitin and natural solid lipsomes to sunscreen. Pure chitin is not solved completely in majority chemical agents and traditional chemical UV blockers are potentially harmful to human skin. So the combination of chemical UV absorber and chitin formed 3,4,5-trimethoxybenzoylchitin (TMBC), which was proven as an active chemical sunscreen by Dr. Clausen, and can overcome their inherent defects. Lipophilic ability of the new material can be increased while harmfulness can be decreased due to incorporation natural material chitin. Then solid lipid nanoparticles (SLN) loaded with TMBC to act both as physical sunscreens themselves and as carriers in order to enhance the effect of UVB protection. The improvement of the system can been observed when tocopherol was added.
authors: Chemistry College, Nankai University, 94 Weijin Road, Tianjin 300071, PR China. songchunjin@yahoo.com.cn
authors: Chunjin
authors: C
authors: Song
authors: Shuangxi
authors: S
authors: Liu
mesh_terms: D002686:Chitin / Q000031:analogs & derivatives* / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D008863:Microspheres; D049329:Nanostructures; D036103:Nanotechnology; D012867:Skin; D013055:Spectrophotometry, Infrared; D013473:Sunscreening Agents / Q000737:chemistry*; D014466:Ultraviolet Rays; D014810:Vitamin E / Q000737:chemistry*
chemical_list: C505933:3,4,5-trimethoxybenzoylchitin; D004337:Drug Carriers; D008055:Lipids; D013473:Sunscreening Agents; D002686:Chitin; D014810:Vitamin E