Patients with mild Alzheimer's disease attribute conceptual fluency to prior experience.
Patients with Alzheimer's disease (AD) have been found to be relatively dependent on familiarity in their recognition memory judgments. Conceptual fluency has been argued to be an important basis of familiarity. This study investigated the extent to which patients with mild AD use conceptual fluency cues in their recognition decisions. While no evidence of recognition memory was found in the patients with AD, enhanced conceptual fluency was associated with a higher rate of "Old" responses (items endorsed as having been studied) compared to when fluency was not enhanced. The magnitude of this effect was similar for patients with AD and healthy control participants. Additionally, ERP recordings time-locked to test item presentation revealed preserved modulations thought critical to the effect of conceptual fluency on test performance (N400 and late frontal components) in the patients with AD, consistent with the behavioral results. These findings suggest that patients with mild AD are able to use conceptual fluency in their recognition judgments and the neural mechanisms supporting such processing is maintained.
Wolk
David A
DA
Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. dwolk@partners.org
Schacter
Daniel L
DL
Berman
Alyssa R
AR
Holcomb
Phillip J
PJ
Daffner
Kirk R
KR
Budson
Andrew E
AE
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000503:physiopathology*; D000704:Analysis of Variance; D016022:Case-Control Studies; D004569:Electroencephalography / Q000379:methods; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D011930:Reaction Time / Q000502:physiology; D021641:Recognition, Psychology; D014706:Verbal Learning / Q000502:physiology*