Classical dengue hemorrhagic fever resulting from two dengue infections spaced 20 years or more apart: Havana, Dengue 3 epidemic, 2001-2002.
OBJECTIVE
To report the clinical, laboratory and sonographic findings in 76 adult cases of dengue hemorrhagic fever (DHF).


METHODS
A dengue 3 epidemic occurred in Havana City from June 2001 to March 2002. 12,889 cases were reported, with 81 DHF cases. From this, 76 serologically confirmed cases were studied descriptively.


RESULTS
Bronchial asthma and white race were important risk factors for the severe form of the disease. Fever (100%), headache (92.1%), myalgia (76.3%), arthralgia (73.7%) and retro-orbital pain (57.7%) were the most frequent general symptoms. Vomiting and abdominal pain were observed in 59.2% and 48.6% of cases, respectively. The most common bleeding site was the vagina (64%), followed by the skin (55.2%). Eighteen patients (23.6%) had shock syndrome. Laboratory findings included thrombocytopenia (100%), hemoconcentration (93.4%), an increase in liver enzymes (82.8%), and leukopenia (71%). Ultrasound detected thickening of the gallbladder wall in 35.1%, pleural effusion in 20.3%, and splenomegaly in 12.9% of cases.


CONCLUSIONS
These findings contribute to a better understanding of the clinical aspects of DHF in adult patients due to the dengue 3 virus.
González
Daniel
D
Pedro Kouri Tropical Medicine Institute, Virology Department, Autopista Novia del Mediodía, La Lisa, Havana City, Cuba.
Castro
Osvaldo E
OE
Kourí
Gustavo
G
Perez
Jorge
J
Martinez
Eric
E
Vazquez
Susana
S
Rosario
Delfina
D
Cancio
Reynel
R
Guzman
María G
MG
D015746:Abdominal Pain / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D018771:Arthralgia / Q000473:pathology; D003462:Cuba / Q000453:epidemiology; D004196:Disease Outbreaks; D005260:Female; D005334:Fever / Q000473:pathology; D006261:Headache / Q000473:pathology; D006470:Hemorrhage / Q000473:pathology; D006801:Humans; D008107:Liver Diseases / Q000201:enzymology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D019595:Severe Dengue / Q000175:diagnosis* / Q000453:epidemiology*; D012867:Skin / Q000473:pathology; D013921:Thrombocytopenia / Q000473:pathology; D014621:Vagina / Q000473:pathology; D014839:Vomiting / Q000473:pathology