Thrombosis in hemophiliacs with prothrombotic molecular defect.
Thrombosis in hemophiliacs is a very unusual event mostly reported in patients treated with concentrates containing large quantities of activated coagulation factors. A patient with hemophilia A is reported who had an acute myocardial infarction and in whom investigation for hereditary thrombophilia showed a prothrombotic molecular defect, the G20210A prothrombin mutation.
Iannaccaro
Piergiorgio
P
Hemophilia Center, Azienda Ospedaliera "Pugliese-Ciaccio", Catanzaro, Italy. emofiliacz@virgilio.it
Santoro
Rita
R
Sottilotta
Gianluca
G
Papaleo
Giuseppina
G
Muleo
Gaetano
G
D019943:Amino Acid Substitution; D005165:Factor V / Q000235:genetics; D005169:Factor VIII / Q000032:analysis; D006467:Hemophilia A / Q000097:blood / Q000150:complications / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011516:Prothrombin / Q000235:genetics*; D013927:Thrombosis / Q000209:etiology*
C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D005169:Factor VIII