Serotonin uptake to lymphocytes of patients with social phobia compared to normal individuals.
Several trials have indicated that selective serotonin reuptake inhibitors (SSRIs) are most efficient in the treatment of social phobia (SP). The activity of the serotonin transporter (5-HTT), as determined by [3H]5-HT uptake to blood lymphocytes, was measured in 15 drug-free patients with generalized SP (7M/8F, aged 21-37 years) and compared to 18 healthy control subjects (10M/8F, aged 21-32 years). The maximum uptake velocity (Vmax) of [3H]5-HT to fresh lymphocytes and the affinity (Km) of the 5-HTT were similar in the two groups (295+/-155 versus 227+/-117 pmol/min/mg protein and 767+/-425 versus 709+/-408 nM, respectively). This study suggests that the functioning of lymphocyte 5-HTT is unaltered in SP.
Barkan
Tal
T
Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Hermesh
Haggai
H
Marom
Sofi
S
Gurwitz
David
D
Weizman
Abraham
A
Rehavi
Moshe
M
D000328:Adult; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010698:Phobic Disorders / Q000378:metabolism / Q000473:pathology*; D012701:Serotonin / Q000378:metabolism* / Q000493:pharmacokinetics; D012720:Severity of Illness Index; D014316:Tritium / Q000378:metabolism / Q000493:pharmacokinetics
D014316:Tritium; D012701:Serotonin