[Preventive effect of chitosan on capsular contracture after implantation of silicone gel-filled mammary implants in rats].
OBJECTIVE
To study the preventive effect of chitosan on capsular contracture after implantation of silicone gel-filled mammary implants in rats.


METHODS
18 SD female rats were divided into three groups randomly. Small silicone gel-filled mammary implants were implanted under each side of latissimus dorsi muscle. Chitosan was injected into left cavities as experimental sides, and nothing was injected into right cavities as control sides. 4, 8 and 12 weeks postoperation, specimens were dissected and observed using light microscope, and area density of collagen both type I and type III were also detected.


RESULTS
Fibrous capsules around implants consist of two layers: dense layer and loose layer. 4 weeks postoperation, total thickness of the experimental sides was less than that of the control sides (P < 0.01). Area density of collagen either type I or type III of the experimental sides was lower than that of the control sides (P < 0.01). Both 8 and 12 weeks postoperation, total thickness of the experimental sides was less than that of the control sides (P < 0.05). Area density of collagen type I of the experimental sides was lower than that of the control sides (P < 0.05). Area density of collagen type III was of no statistical difference between the experimental sides and the control sides (P > 0.05).


CONCLUSIONS
Chitosan can remarkably prevent capsule contracture during the early period after implantation of silicone gel-filled mammary implants.
Yan
Ying-Jun
YJ
Plastic Surgery Hospital, Chinese Academy of Medical Science, Beijing 100041, China.
Qiao
Qun
Q
Sun
Jia-Ming
JM
Liu
Zhi-Fei
ZF
Song
Ke-Xin
KX
Yue
Ying
Y
Sun
Bao-Dong
BD
D000818:Animals; D019928:Breast Implantation; D018427:Breast Implants / Q000009:adverse effects*; D048271:Chitosan / Q000627:therapeutic use*; D003286:Contracture / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D008321:Mammary Glands, Animal / Q000601:surgery; D051381:Rats; D017207:Rats, Sprague-Dawley; D020034:Silicone Gels / Q000009:adverse effects*
D020034:Silicone Gels; D048271:Chitosan