title: [A case of high grade astrocytoma arising in the hand area of precentral gyrus].
abstract: A 23-year-old man presented with the right upper monoparesis. The right little finger paresis was apparent at first, and ring finger two weeks later, and middle, index, thumb were simultaneously four weeks later. Then the monoparesis gradually progressed to the proximal upper limb. Magnetic resonance imaging showed a small lesion at the knob of the left precentral gyrus. The lesion was low-intensity on T1-, and high-intensity on T2-weighted images, and clearly detected on high-intensity on FLAIR images, but showed no enhancement by gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA). Angiography and thallium scintigraphy showed no remarkable findings. Proton MR spectroscopy demonstrated lower N-acetylaspartate (NAA) and higher choline (Cho) level compared to the contralateral cortico-subcortical area. Diffusion weighted images demonstrated low apparent diffusion coefficient (ADC) value and high intensity on b = 1,000. To clarify the diagnosis of the lesion, we performed open biopsy by using the neuronavigation system to detect the lesion accurately and minimize the biopsy. Histological examination revealed an high grade astrocytoma with high MlIB-1 index over 30%. The progressive symptoms were due to highly infiltrative and proliferative nature of the tumor arising in the focal hand area of the primary motor cortex, according to the homunculus. We discuss herein the neuroimagings of the case that was considered to be in the initial stage of a malignant tumor.
authors: Department of Neurological Surgery, Wakayama Medical University, Kimiidera 811-1, Wakayama 641-0012, Japan.
authors: Hiroki
authors: H
authors: Nishibayashi
authors: Yoshikazu
authors: Y
authors: Matsuda
authors: Yuji
authors: Y
authors: Uematsu
authors: Naoyuki
authors: N
authors: Nakao
authors: Tomoaki
authors: T
authors: Terada
authors: Tohru
authors: T
authors: Itakura
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D001254:Astrocytoma / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D003131:Combined Modality Therapy; D038524:Diffusion Magnetic Resonance Imaging; D004334:Drug Administration Schedule; D019786:Gadolinium DTPA; D006801:Humans; D016899:Interferon-beta / Q000008:administration & dosage; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009044:Motor Cortex / Q000473:pathology*; D009607:Nitrosourea Compounds / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D009607:Nitrosourea Compounds; D001224:Aspartic Acid; D014750:Vincristine; D016899:Interferon-beta; C000179:N-acetylaspartate; D019786:Gadolinium DTPA; C020766:ranimustine