title: [Preparation, identification and inclusion actions of irisquinone hydroxypropyl-beta-cyclodextrin inclusion complex].
abstract: OBJECTIVE
  To perpare and identify irisquinone hydroxypropyl-beta-cyclodextrin inclusion complex (irisquinone-HP-beta-CD), as well as to study the inclusion mechanism and molecule stoichiometry between irisquinone and hydroxypropyl-beta-cyclodextrin.
  
  
  METHODS
  Irisquinone-HP-beta-CD was prepared by freeze-drying technique. The ratio of host and guest was also studied in inclusion process by mol gradient and continuing variational methods. At the same time, the inclusion complex was identified by X-ray diffraction (XRD) and differential scanning calorimetry (DSC).
  
  
  RESULTS
  It was demonstrated that the solubility of irisquinone was enhanced markedly by inclusion with HP-beta-CD when stoichiometry was 2:1 of host and guest at 25 degrees C, 35 degrees C and 45 degrees C.
  
  
  CONCLUSIONS
  The solubility and stability of irisquinone could be increased by preparing the inclusion complex with hydroxypropyl-beta-cyclodextrin.
authors: Department of Pharmacy, Suzhou University, Suzhou 215007, China. zhangxuenong@163.com
authors: Xue-nong
authors: XN
authors: Zhang
authors: Xue-ying
authors: XY
authors: Yan
authors: Li-hua
authors: LH
authors: Tang
authors: Jin-hong
authors: JH
authors: Gong
authors: Qiang
authors: Q
authors: Zhang
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D016227:Benzoquinones / Q000008:administration & dosage* / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D004339:Drug Compounding / Q000379:methods*; D004355:Drug Stability; D005612:Freeze Drying; D012995:Solubility; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D016227:Benzoquinones; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; C032941:irisquinone