title: Molecular cytogenetics analysis with whole chromosome paint probes of sperm nuclei from a (13;15) Robertsonian translocation carrier.
abstract: Meiotic segregation of a Robertsonian translocation (13;15) was assessed in sperm nuclei using dual-color fluorescent in situ hybridization (FISH) with whole-chromosome paint probes. Most spermatozoa in the (13;15) translocation carrier resulted from alternate segregation. Although an increased frequency of unbalanced gametes was observed, spontaneous pregnancy led to the birth of a boy with a normal karyotype.
authors: Laboratoire de Biologie de la Reproduction-CECOS, CHU Charles Nicolle, Rouen, France. nathalie.rives@chu-rouen.fr.
authors: Nathalie
authors: N
authors: Rives
authors: Service d'Histologie, Biologie de la Reproduction et Cytogénétique, Hôpital Tenon, Paris, France.
authors: Célia
authors: C
authors: Ravel
authors: Laboratoire de Biologie de la Reproduction-CECOS, CHU Charles Nicolle, Rouen, France.
authors: Véronique
authors: V
authors: Duchesne
authors: Service d'Histologie, Biologie de la Reproduction et Cytogénétique, Hôpital Tenon, Paris, France.
authors: Jean-Pierre
authors: JP
authors: Siffroi
authors: Laboratoire de Biologie de la Reproduction-CECOS, CHU Charles Nicolle, Rouen, France.
authors: Nathalie
authors: N
authors: Mousset-Siméon
authors: Laboratoire de Biologie de la Reproduction-CECOS, CHU Charles Nicolle, Rouen, France.
authors: Bertrand
authors: B
authors: Macé
mesh_terms: D020223:Chromosome Painting; D020090:Chromosome Segregation / Q000235:genetics*; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics*; D020732:Cytogenetic Analysis / Q000379:methods; D005817:Genetic Counseling; D006801:Humans; D008297:Male; D013094:Spermatozoa / Q000737:chemistry*; D014178:Translocation, Genetic / Q000235:genetics*