[125I seed implantation in sphincter preservation for treatment of low rectal cancer].
OBJECTIVE
To evaluate the effects of (125)I seed implantation in sphincter preservation for treatment of low rectal cancer.


METHODS
Seventy-six patients with low rectal cancer were randomly divided into 2 group: group A, 17 males and 13 females, aged 48.5 +/- 2.4, receiving rectostomy and anal sphincter preservation and group B, 24 males and 22 females, aged 49.4 +/- 2.6, receiving modified TME and anal sphincter preservation combined with brachytherapy by (125)I seed implantation. Two to four weeks after operation chemotherapy with 5-FU/CF were performed. Follow-up was carried out 6, 12, 24, and 36 months after operation.


RESULTS
The local recurrence rates 6, 12, 24, and 36 months after operation were 0%, 11.1%, 14.3%, and 23% respectively in the group A, and all 0% in the group B (P < 0.05 for the rate 36 months later). The survival rates 6, 12, 24, and 36 months after operation were 100%, 100%, 85.7%, and 76.7% respectively in the group A, and were 100%, 100%, 97.1%, and 93% respectively in the group B (P < 0.05 for the rate 36 months later). The functions of defecation and erection were better in the group B and the symptom of pain was improved better in the group A too (all P < 0.05).


CONCLUSIONS
Safe, simple, and effective, surgery with sphincter preservation combined with brachytherapy in low rectal cancer is one of the ideal methods for treatment of low rectal cancer.
Luo
Kai-yuan
KY
Department of Surgery, Second People's Hospital of Yunnan Province, Fourth affiliated Hospital of Kunming Medical College, Kunming 650021, China.
Shao
Qing-hua
QH
Yang
Guo-kai
GK
Mao
Wen-yuan
WY
Li
Bo
B
Yang
Rong
R
Duan
Bao-feng
BF
Yang
Yong
Y
Wang
Ming-chun
MC
Liu
Wen-zhuo
WZ
D000230:Adenocarcinoma / Q000532:radiotherapy / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016737:Proctocolectomy, Restorative; D018714:Radiotherapy, Adjuvant; D012004:Rectal Neoplasms / Q000532:radiotherapy* / Q000601:surgery*
D007457:Iodine Radioisotopes