title: Solid-phase synthesis and anti-infective activity of a combinatorial library based on the natural product anisomycin.
abstract: The solid-phase synthesis of a library based on the natural product anisomycin is described. The resulting library was tested against a panel of bacterial and fungal targets, and active compounds were identified in a Staphylococcus aureus whole-cell assay and an efflux-deficient fungal whole-cell assay.
authors: New Leads Chemistry, 5 Research Parkway, Wallingford, CT 06492, USA. shij@bms.com
authors: Shuhao
authors: S
authors: Shi
authors: Shirong
authors: S
authors: Zhu
authors: Samuel W
authors: SW
authors: Gerritz
authors: Kim
authors: K
authors: Esposito
authors: Ramesh
authors: R
authors: Padmanabha
authors: Wenying
authors: W
authors: Li
authors: John J
authors: JJ
authors: Herbst
authors: Henry
authors: H
authors: Wong
authors: Yue Zhong
authors: YZ
authors: Shu
authors: Kin S
authors: KS
authors: Lam
authors: Michael J
authors: MJ
authors: Sofia
mesh_terms: D000841:Anisomycin / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry*; D002460:Cell Line; D020650:Combinatorial Chemistry Techniques; D005658:Fungi / Q000166:cytology / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000166:cytology / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D001688:Biological Products; D000841:Anisomycin