title: Intravenous aminophylline provides no additional renal protection in patient with severe atherosclerotic renal artery stenosis treated by delicate percutaneous renal intervention.
abstract: BACKGROUND
  Clinical trials on contrast-induced nephropathy (CIN) prevention with different approaches generated various results. In this study, we investigated whether intravenous aminophylline preceding percutaneous transluminal renal artery stenting (PTRS) might provide better renal protection.
  
  
  METHODS
  Patients with severe atherosclerotic renal artery stenosis and undergoing PTRS were prospectively studied. Intravenous aminophylline 250 mg was administered 30 min before PTRS.
  
  
  RESULTS
  The aminophylline group included 15 patients (mean age, 68+/-4 years) and the case-matched control group consisted of another 15 patients (mean age, 71+/-2 years). After a mean follow-up of 5-6 months, both groups showed similar serum creatinine (1.7+/-0.2 vs. 1.6+/-0.1 mg/dl, P=NS), BUN (20.0+/-3.0 vs. 24.0+/-3.0 mg/dl, P=NS), fall in systolic (-15+/-13 vs. -11+/-3 mm Hg, P=NS) and diastolic BP (-2+/-4 vs. -6+/-5 mm Hg, P=NS). The incidence of post-operative renal deterioration was 6.7% in the study group and none in the control group.
  
  
  CONCLUSIONS
  Pre-treatment intravenous aminophylline provides no additional renal protective effect in delicately practiced PTRS.
authors: Chen-Rong
authors: CR
authors: Tsao
authors: Tsun-Jui
authors: TJ
authors: Liu
authors: Fu-Chung
authors: FC
authors: Chen
authors: Yong-Hua
authors: YH
authors: Chu
authors: Hong-Yun
authors: HY
authors: Her
authors: Wei-Wen
authors: WW
authors: Lin
authors: Kuo-Yang
authors: KY
authors: Wang
authors: Ying-Tsung
authors: YT
authors: Chen
authors: Chih-Tai
authors: CT
authors: Ting
authors: Wen-Lieng
authors: WL
authors: Lee
mesh_terms: D000368:Aged; D000628:Aminophylline / Q000008:administration & dosage*; D000800:Angioplasty, Balloon; D001161:Arteriosclerosis / Q000628:therapy*; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D011446:Prospective Studies; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging / Q000628:therapy*; D015607:Stents; D014463:Ultrasonography
chemical_list: D002316:Cardiotonic Agents; D000628:Aminophylline