title: Analysis of structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as TRPV1 antagonists.
abstract: The structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues have been investigated as TRPV1 receptor antagonists. The 2-halogen analogues showed enhanced antagonism compared to the prototype antagonist.
authors: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea. jeewoo@snu.ac.kr
authors: Jeewoo
authors: J
authors: Lee
authors: Sang-Uk
authors: SU
authors: Kang
authors: Min-Jung
authors: MJ
authors: Kil
authors: Myoungyoup
authors: M
authors: Shin
authors: Ju-Ok
authors: JO
authors: Lim
authors: Hyun-Kyung
authors: HK
authors: Choi
authors: Mi-Kyoung
authors: MK
authors: Jin
authors: Su Yeon
authors: SY
authors: Kim
authors: Sung-Eun
authors: SE
authors: Kim
authors: Yong-Sil
authors: YS
authors: Lee
authors: Kyung-Hoon
authors: KH
authors: Min
authors: Young-Ho
authors: YH
authors: Kim
authors: Hee-Jin
authors: HJ
authors: Ha
authors: Richard
authors: R
authors: Tran
authors: Jacqueline D
authors: JD
authors: Welter
authors: Yun
authors: Y
authors: Wang
authors: Tamas
authors: T
authors: Szabo
authors: Larry V
authors: LV
authors: Pearce
authors: Daniel J
authors: DJ
authors: Lundberg
authors: Attila
authors: A
authors: Toth
authors: Vladimir A
authors: VA
authors: Pavlyukovets
authors: Matthew A
authors: MA
authors: Morgan
authors: Peter M
authors: PM
authors: Blumberg
mesh_terms: D000818:Animals; D016466:CHO Cells; D002118:Calcium / Q000378:metabolism; D006224:Cricetinae; D008024:Ligands; D015394:Molecular Structure; D051381:Rats; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry / Q000494:pharmacology*; D050916:TRPV Cation Channels / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013890:Thiourea / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D008024:Ligands; C505274:N-(4-t-butylbenzyl)-N'-(4-(methylsulfonylamino)benzyl)thiourea; D013449:Sulfonamides; D050916:TRPV Cation Channels; C494484:TRPV1 receptor; D013890:Thiourea; D002118:Calcium