title: Rapid awareness and transmission of severe acute respiratory syndrome in Hanoi French Hospital, Vietnam.
abstract: A case-control study was conducted to examine the relationship between severe acute respiratory syndrome (SARS) and the time-dependent precautionary behaviors taken during an outbreak of SARS in Hanoi French Hospital (HFH), Vietnam. Masks (odds ratio [OR] = 0.3; 95% confidence interval [CI]: 0.1, 0.7) and gowns (OR = 0.2; 95% CI: 0.0, 0.8) appeared to prevent SARS transmission. The proportion of doctors and nurses who undertook each measure significantly improved (chi(2) = 9.8551, P = 0.043) after the onset of secondary cases. The impact of individual behaviors on an outbreak was investigated through mathematical approaches. The reproduction number decreased from 4.1 to 0.7 after notification. The basic reproduction number was estimated, and the use of masks alone was shown to be insufficient in containing an epidemic. Intuitive results obtained by means of stochastic individual-based simulations showed that rapid improvements in behavior and isolation would increase the probability of extinction.
authors: The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan.
authors: Hiroshi
authors: H
authors: Nishiura
authors: Tadatoshi
authors: T
authors: Kuratsuji
authors: Tran
authors: T
authors: Quy
authors: Nguyen Chi
authors: NC
authors: Phi
authors: Vo
authors: V
authors: Van Ban
authors: L E Dang
authors: LE
authors: Ha
authors: Hoang Thuy
authors: HT
authors: Long
authors: Hideki
authors: H
authors: Yanai
authors: Naoto
authors: N
authors: Keicho
authors: Teruo
authors: T
authors: Kirikae
authors: Takehiko
authors: T
authors: Sasazuki
authors: Roy M
authors: RM
authors: Anderson
mesh_terms: D000704:Analysis of Variance; D016022:Case-Control Studies; D003020:Clothing; D003428:Cross Infection / Q000517:prevention & control / Q000635:transmission / Q000821:virology*; D004196:Disease Outbreaks; D006235:Hand Disinfection; D006801:Humans; D006920:Hygiene; D015233:Models, Statistical; D045473:Severe acute respiratory syndrome-related coronavirus; D045169:Severe Acute Respiratory Syndrome / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission*; D014744:Vietnam / Q000453:epidemiology