Correlation of retinal sensitivity measured with fundus-related microperimetry to visual acuity and retinal thickness in eyes with diabetic macular edema.
OBJECTIVE
To determine whether significant correlations exist between retinal sensitivity measured by fundus-related microperimetry and the visual acuity and the foveal thickness measured by optical coherence tomography (OCT) in eyes with diabetic macular edema (DME).


METHODS
A retrospective chart review of 32 eyes with DME and 17 normal healthy eyes that had undergone fundus-related microperimetry and OCT. The macular sensitivity was measured using the recently introduced fundus-related microperimeter, Micro Perimeter 1. The mean retinal sensitivities within the central 2 degrees and 10 degrees were correlated with the best-corrected visual acuity and OCT-measured foveal retinal thickness.


RESULTS
The mean sensitivities in the central 2 degrees and 10 degrees were significantly lower in patients with DME than in normal subjects (P<0.0001). The mean retinal sensitivities in the central 2 degrees and 10 degrees were inversely correlated with visual acuity (r(2)=0.623, P<0.0001; r(2)=0.581, P<0.0001) and foveal thickness (r(2)=0.581, P<0.0001; r(2)=0.551, P<0.0001).


CONCLUSIONS
The mean retinal sensitivities measured with fundus-related microperimetry were significantly lower in eyes with DME than in normal eyes. Because a significant correlation of the microperimeter-determined retinal sensitivity to visual acuity and foveal thickness was observed, the retinal sensitivities obtained by fundus-related microperimetry may be another measure that can be used to assess the effects of DME.
Okada
K
K
Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Inohana, Chuo-ku, Chiba, Japan.
Yamamoto
S
S
Mizunoya
S
S
Hoshino
A
A
Arai
M
M
Takatsuna
Y
Y
D000328:Adult; D000368:Aged; D003930:Diabetic Retinopathy / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D005584:Fovea Centralis / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008269:Macular Edema / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012720:Severity of Illness Index; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology*; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology