[Methiothepin-sensitive serotonin receptors are involved in postsynaptic mechanism of sensitization of Helix lucorum escape reaction].
Tetanic electric stimulation of Helix foot evokes sensitization of escape reaction. This behavioral sensitization and posttetanic potentiation (PTP) of acetylcholine-induced inward current (ACh-current) in command Helix neurons of escape behavior were similar. Antagonist of serotonin receptors methiothepin prevents the PTP of the ACh-current and behavioral sensitization. Serotonin disrupts the PTP of the ACh-current. It is suggested that the increase in cholinosensitivity of the command neurons with the involvement of methiothepin-sensitive serotonin receptors may be the cellular postsynaptic mechanism of behavioral sensitization of Helix escape reaction.
Abramova
M S
MS
Nistratova
V L
VL
Moskvitin
A A
AA
Pivovarov
A S
AS
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D004558:Electric Stimulation; D004924:Escape Reaction / Q000187:drug effects / Q000502:physiology*; D006372:Helix, Snails / Q000187:drug effects / Q000502:physiology*; D008564:Membrane Potentials; D008719:Methiothepin / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D044263:Receptors, Serotonin, 5-HT1 / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology*; D009435:Synaptic Transmission
D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists; D012701:Serotonin; D008719:Methiothepin; D000109:Acetylcholine