title: Simulation of cardiac pathologies using an electromechanical biventricular model and XMR interventional imaging.
abstract: Simulating cardiac electromechanical activity is of great interest for a better understanding of pathologies and for therapy planning. Design and validation of such models is difficult due to the lack of clinical data. XMR systems are a new type of interventional facility in which patients can be rapidly transferred between X-ray and MR systems. Our goal is to design and validate an electromechanical model of the myocardium using XMR imaging. The proposed model is computationally fast and uses clinically observable parameters. We present the integration of anatomy, electrophysiology, and motion from patient data. Pathologies are introduced in the model and simulations are compared to measured data. Initial qualitative comparison on the two clinical cases presented is encouraging. Once fully validated, these models will make it possible to simulate different interventional strategies.
authors: Cardiac MR Research Group, King's College London, 5th Floor Thomas Guy House, Guy's Hospital, London, UK. maxime.sermesant@kcl.ac.uk
authors: M
authors: M
authors: Sermesant
authors: K
authors: K
authors: Rhode
authors: G I
authors: GI
authors: Sanchez-Ortiz
authors: O
authors: O
authors: Camara
authors: R
authors: R
authors: Andriantsimiavona
authors: S
authors: S
authors: Hegde
authors: D
authors: D
authors: Rueckert
authors: P
authors: P
authors: Lambiase
authors: C
authors: C
authors: Bucknall
authors: E
authors: E
authors: Rosenthal
authors: H
authors: H
authors: Delingette
authors: D L G
authors: DL
authors: Hill
authors: N
authors: N
authors: Ayache
authors: R
authors: R
authors: Razavi
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008955:Models, Cardiovascular; D009200:Myocardial Contraction; D013382:Subtraction Technique; D014057:Tomography, X-Ray Computed / Q000379:methods*; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*