title: [Preparation of 5-fluorouracil-peanut agglutinin conjugate and determination of the ratio of drug to conjugate].
abstract: 5-fluorouracil was combined with peanut agglutinin by a water-soluble carbodiimide to prepare the tumor target conjugate of 5-fluorouracil-peanut agglutinin and the ratio of drug to conjugate was determined by the modified trinitrobenzenesulfonic acid method (TNBS). The ratio of drug to conjugate was 76.33%. The result showed that 5-fluorouracil could link to the peanut agglutinin by EDC/NHS crosslinking with high drug ratio.
authors: West China Pharmacy College of Sichuan University, Chengdu 610041, China.
authors: Qin
authors: Q
authors: Cai
authors: Yanfa
authors: Y
authors: Meng
authors: Zhirong
authors: Z
authors: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry; D005472:Fluorouracil / Q000737:chemistry*; D019887:Peanut Agglutinin / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D003432:Cross-Linking Reagents; D019887:Peanut Agglutinin; D005472:Fluorouracil