High maternal estriol level in pregnancy as a predictor of surgical intervention for undescended testis.
To assess whether elevated levels of estriol (E3) in pregnancy are a factor in the fetal environment associated with undescended testes, we carried out a two-part study: case-control followed by a retrospective cohort study on cryptorchid boys born in the Sapir Medical Center (Kfar Saba, Israel). We found significantly lower pregnancy urinary E3 levels in cryptorchid newborns as compared to controls; however, subgroup comparison yielded significantly higher pregnancy unconjugated E3 levels in the infants who underwent orchiopexy as compared to those who did not.
Nutman
Amir
A
Department of Obstetrics and Gynecology, Sapir Medical Center, Kfar Saba, Israel.
Freud
Enrique
E
Itzhaky
Dganit
D
Dolfin
Tzipora
T
Tepper
Ronnie
R
D000328:Adult; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003456:Cryptorchidism / Q000097:blood* / Q000601:surgery*; D004964:Estriol / Q000097:blood*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D011237:Predictive Value of Tests; D011247:Pregnancy; D012189:Retrospective Studies
D004964:Estriol