title: Lindane-induced immunological alterations in human poisoning cases.
abstract: OBJECTIVE
  Evaluation of immunological alterations in the blood of human lindane poisoning cases.
  
  
  METHODS
  Serum IgG, IgM, IgA, IgE, IL-2, IL-4, TNF-alpha, and IFN-gamma levels were measured using immunoassay in 20 human cases of lindane poisoning. The presence of lindane in blood was confirmed by HPLC.
  
  
  RESULTS
  Serum IL-2, IL-4, and TNF-alpha levels were significantly raised with decrease in IFN-gamma levels in the lindane-exposed cases. Immunoglobulin levels were not altered.
  
  
  CONCLUSIONS
  The results suggest that lindane exposure at chronically high levels affects cytokine levels in humans and indicates the severity of immunotoxicity.
authors: Department of Biochemistry, Environmental Biochemistry Laboratory, UCMS & G.T.B. Hospital, Dilshad Garden, Delhi-110 095, India.
authors: Vandana
authors: V
authors: Seth
authors: Rafat S
authors: RS
authors: Ahmad
authors: Sanvidhan G
authors: SG
authors: Suke
authors: Sayed T
authors: ST
authors: Pasha
authors: Abhijit
authors: A
authors: Bhattacharya
authors: Basu D
authors: BD
authors: Banerjee
mesh_terms: D000917:Antibody Formation / Q000187:drug effects*; D001556:Hexachlorocyclohexane / Q000506:poisoning*; D007109:Immunity / Q000187:drug effects*; D007136:Immunoglobulins / Q000097:blood; D007371:Interferon-gamma / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D011041:Poisoning / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D007136:Immunoglobulins; D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D015847:Interleukin-4; D001556:Hexachlorocyclohexane; D007371:Interferon-gamma