title: [Nitric oxide and nitric oxide synthase in patients with chronic hepatitis B].
abstract: OBJECTIVE
  To investigate nitric oxide (NO) and nitric oxide synthase (NOS) in patients with chronic hepatitis B.
  
  
  METHODS
  Nitric oxide and nitric oxide synthase, including inducible NOS (iNOS) and constitutive NOS (cNOS), were measured in patients and control groups, then were statistically analyzed.
  
  
  RESULTS
  NO and iNOS were significantly higher in patients with hepatitis B than in the controls (P < 0.05). NO and iNOS were significantly higher in patients with increased ALT than in the controls and in patients with normal ALT (P < 0.05). NO was significantly higher in patients with normal ALT than in the controls (P < 0.05). cNOS were not significant different among these groups. NO and iNOS significantly correlated with ALT in patients with hepatitis B (r=0.367 and r=0.474). No significant relationship was found among NO, NOS and HBV DNA. Among different genotype groups, NO and NOS had no significant difference.
  
  
  CONCLUSIONS
  NO and NOS were higher in patents with chronic hepatitis B. In patients with increased ALT, NO's damage was severe. In patients with normal ALT, there was no significant damage caused by NO. NO should be detected in patients with hepatitis B in addition to HBV markers.
authors: Department of Liver Disease, Qilu Hospital, Shandong University, Jinan 250012, China.
authors: Kai
authors: K
authors: Wang
authors: Li-yan
authors: LY
authors: Han
authors: Qin
authors: Q
authors: Lu
authors: Bing
authors: B
authors: Wang
authors: Xin-he
authors: XH
authors: Li
authors: Hui-min
authors: HM
authors: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005838:Genotype; D006515:Hepatitis B virus / Q000235:genetics; D019694:Hepatitis B, Chronic / Q000097:blood / Q000378:metabolism* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D055815:Young Adult
chemical_list: D004279:DNA, Viral; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D000410:Alanine Transaminase