title: Towards the combinatorial synthesis of spongistatin fragment libraries by using asymmetric aldol reactions on solid support.
abstract: By relying on asymmetric boron-mediated aldol reactions, solid phase methodology for the stereoselective synthesis of highly substituted spiroacetals was developed and applied to the preparation of a complex AB-spiroacetal subunit of the antimitotic agent spongistatin 1 (altohyrtin A).
authors: University Chemical Laboratory, Lensfield Road, Cambridge, UK CB2 1EW. ip100@cam.ac.uk
authors: Ian
authors: I
authors: Paterson
authors: Dirk
authors: D
authors: Gottschling
authors: Dirk
authors: D
authors: Menche
mesh_terms: D050256:Antimitotic Agents / Q000138:chemical synthesis; D001895:Boron; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D018942:Macrolides / Q000138:chemical synthesis*; D013141:Spiro Compounds; D013237:Stereoisomerism; D050257:Tubulin Modulators / Q000138:chemical synthesis; D000095702:Polyether Toxins
chemical_list: D050256:Antimitotic Agents; D001895:Boron; D018942:Macrolides; D013141:Spiro Compounds; D050257:Tubulin Modulators; C083856:spongistatin 1; D000095702:Polyether Toxins