[Fibrinogen substitution. Use in the treatment of bleeding due to lack of fibrinogen].
Fibrinogen is critically important in haemostasis. The concentration of fibrinogen in plasma is usually between 2 and 4 g/l (6-13 micromol/l). No detectable fibrinogen is found in afibrinogenaemia, a condition characterised by dramatic bleeding, while dys- and hypofibrinogenaemia have a lower-than-normal activity of functional fibrinogen. Acquired fibrinogen deficiency may occur with a variety of underlying pathologies. Fibrinogen substitution may be done with fresh-frozen plasma, cryoprecipitate and virally inactivated concentrates of fibrinogen.
Ingerslev
Jørgen
J
Klinisk Biokemisk Afdeling, Center for Haemofili og Trombose, Skejby Sygehus, Aarhus Universitetshospital, DK-8200 Arhus. ingerslev@ki.au.dk
Sørensen
Benny
B
D000347:Afibrinogenemia / Q000151:congenital / Q000188:drug therapy* / Q000209:etiology; D003029:Coagulants / Q000008:administration & dosage*; D005340:Fibrinogen / Q000008:administration & dosage*; D006470:Hemorrhage / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D006490:Hemostatics / Q000008:administration & dosage*; D006801:Humans
D003029:Coagulants; D006490:Hemostatics; D005340:Fibrinogen