LPO and antiradical defense processes in the liquor of patients with severe craniocerebral injury.
Acute posttraumatic period of severe craniocerebral trauma is associated with sharp activation of LPO processes and rapid exhaustion of antioxidant enzymes and especially low-molecular-weight antioxidant system in the liquor. This leads to the development of severe oxidative stress and failure of adaptation processes during the early posttraumatic period.
Karmen
N B
NB
Laboratory of Thermodynamics and Energy of Complex Biological Systems, Institute of Theoretical and experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia. karmen_iteb@mail.ru
D000328:Adult; D001930:Brain Injuries / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D006801:Humans; D015227:Lipid Peroxidation; D018696:Neuroprotective Agents / Q000627:therapeutic use*
D018696:Neuroprotective Agents