Reversing the discovery paradigm: a new approach to the combinatorial discovery of fluorescent chemosensors.
We report here a new approach to the discovery of fluorescent chemosensors in which a new signaling mechanism allows a core fluorophore to be used in a combinatorial search for new binding events, thus reversing the reigning discovery paradigm.
Mello
Jesse V
JV
Department of Chemistry and Biochemistry, University of California, San Diego 9500 Gilman Drive, La Jolla, California 92093-0358, USA
Finney
Nathaniel S
NS
D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry*; D015374:Biosensing Techniques; D002413:Cations, Divalent; D005449:Fluorenes / Q000138:chemical synthesis / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D008628:Mercury / Q000032:analysis / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry
D000596:Amino Acids; D002413:Cations, Divalent; D005449:Fluorenes; D005456:Fluorescent Dyes; C016456:N(alpha)-fluorenylmethyloxycarbonylamino acids; D011725:Pyridines; D008628:Mercury