title: [Research of markers for the genes of the heavy chain of cardiac beta-myosin and myosin binding protein C in relatives of patients with hypertrophic cardiomyopathy].
abstract: OBJECTIVE
  To study the molecular markers for the genes of the heavy chain of cardiac beta-myosin and the myosin binding protein C in relatives of carriers of hypertrophic cardiomyopathy.
  
  
  METHODS
  Twelve families who had anamnesis, physical exam, electrocardiogram, echocardiogram and blood collection for the genetic study through the chain reaction of polymerase.
  
  
  RESULTS
  From the 227 relatives, 25% were ill-taken, with 51% men, with an average age of 35+/-19 (2 to 95) years old. The genetic analysis showed a connection with the gene of the cardiac b-myosin in a family and, in another, a connection with the gene of the myosin-binding protein C. In five families, the connections with the two genes were excluded; in two, the connection with the gene of the myosin-binding protein C, but for the b-myosin gene the results were non-conclusive; in two families, the results were non-conclusive for both genes and in one the connection for the b-myosin gene was excluded. The results were non-conclusive for the gene of the myosin-binding protein C.
  
  
  CONCLUSIONS
  In our environment, other genes, different from those described in the literature, may prevail, or there are other genetic differences related to the origin of our population and/or environmental factors.
authors: Instituto do Coração do Hospital das Clínicas, FMUSP, São Paulo, Brazil.
authors: Adriana Paula
authors: AP
authors: Tirone
authors: Edmundo
authors: E
authors: Arteaga
authors: Alexandre da Costa
authors: Ada C
authors: Pereira
authors: José Eduardo
authors: JE
authors: Krieger
authors: Paula de Cássia
authors: Pde C
authors: Buck
authors: Barbara Maria
authors: BM
authors: Ianni
authors: Charles
authors: C
authors: Mady
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D024741:Cardiomyopathy, Hypertrophic, Familial / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D018995:Myosin Heavy Chains / Q000235:genetics*; D010375:Pedigree; D010641:Phenotype; D024723:Ventricular Myosins / Q000235:genetics*; D000099163:Myosin Binding Protein C
chemical_list: D002352:Carrier Proteins; D005819:Genetic Markers; D018995:Myosin Heavy Chains; D024723:Ventricular Myosins; D000099163:Myosin Binding Protein C