title: Skin metastasis: an unusual localization from laryngeal carcinoma.
abstract: Skin metastasis from laryngeal carcinoma is rare and indicates a poor prognosis. A case of laryngeal carcinoma with unusual metastasis to the skin of the hand is reported. The patient underwent total laryngectomy, left radical neck dissection, and right functional neck dissection. After the operation, the patient received radiotherapy. In the postoperative 18th month, a mass was observed in the left hand. It was found to be a metastatic tumor from laryngeal carcinoma, histopathologically as well as immunohistochemically. Metastatic potential in malignant neoplasms is generally correlated with reduced cellular adhesiveness. We investigated the expression of the vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), and E-cadherin. Interestingly, the immunohistochemical expression characteristics of such an aggressive tumor were not positive.
authors: Department of Otolaryngology, Medicine Faculty of Kocaeli University, Kocaeli, Turkey. dromeraydin@hotmail.com
authors: Omer
authors: O
authors: Aydin
authors: Emre
authors: E
authors: Ustündağ
authors: Zerrin
authors: Z
authors: Boyaci
authors: Bahar
authors: B
authors: Müezzinoğlu
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006225:Hand / Q000473:pathology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery