title: Appropriate models for the management of infectious diseases.
abstract: BACKGROUND
  Mathematical models have become invaluable management tools for epidemiologists, both shedding light on the mechanisms underlying observed dynamics as well as making quantitative predictions on the effectiveness of different control measures. Here, we explain how substantial biases are introduced by two important, yet largely ignored, assumptions at the core of the vast majority of such models.
  
  
  RESULTS
  First, we use analytical methods to show that (i) ignoring the latent period or (ii) making the common assumption of exponentially distributed latent and infectious periods (when including the latent period) always results in underestimating the basic reproductive ratio of an infection from outbreak data. We then proceed to illustrate these points by fitting epidemic models to data from an influenza outbreak. Finally, we document how such unrealistic a priori assumptions concerning model structure give rise to systematically overoptimistic predictions on the outcome of potential management options.
  
  
  CONCLUSIONS
  This work aims to highlight that, when developing models for public health use, we need to pay careful attention to the intrinsic assumptions embedded within classical frameworks.
authors: Institute of Ecology, University of Georgia, Athens, Georgia, USA. hjw@uga.edu
authors: Helen J
authors: HJ
authors: Wearing
authors: Pejman
authors: P
authors: Rohani
authors: Matt J
authors: MJ
authors: Keeling
mesh_terms: D003141:Communicable Diseases / Q000453:epidemiology* / Q000628:therapy; D004196:Disease Outbreaks; D004812:Epidemiologic Methods; D004813:Epidemiology; D006801:Humans; D007251:Influenza, Human / Q000453:epidemiology* / Q000628:therapy; D008954:Models, Biological; D008962:Models, Theoretical; D011634:Public Health