title: Heparin-induced thrombocytopenia syndrome bullous lesions treated with trypsin-balsam of peru-castor oil ointment: a case study.
abstract: Heparin-induced thrombocytopenia syndrome is a serious, potentially life-threatening adverse reaction to the use of heparin anticoagulation therapy that can result in significant skin damage and organ morbidity. A case study design is used to describe the innovative use of a topical wound treatment (trypsin-balsam of Peru-castor oil ointment) on bullous lesions related to the effects of this syndrome. An elderly, morbidly obese woman was treated for 2 weeks with twice-daily applications of the product along with non-adherent oil emulsion dressings. Oozing decreased substantially within a few days and open blisters closed within 1 week. After 2 weeks of therapy, the bullous skin reaction was fully resolved with no recurrence. The results of this case study suggest that this topical product may have had a positive effect on the bullous lesions and should be considered for use in other similar significant integumentary reactions.
authors: WOCNEP School of Nursing, La Salle University, Philadelphia, PA 19141, UAS. beitz@lasalle.edu
authors: Janice M
authors: JM
authors: Beitz
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects*; D001453:Balsams / Q000737:chemistry / Q000627:therapeutic use*; D001458:Bandages; D001768:Blister / Q000139:chemically induced / Q000517:prevention & control; D002368:Castor Oil / Q000737:chemistry / Q000627:therapeutic use*; D002626:Chemistry, Pharmaceutical; D004338:Drug Combinations; D005260:Female; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D009720:Nurse Clinicians; D009730:Nursing Assessment; D009767:Obesity, Morbid / Q000150:complications; D009824:Ointments; D017592:Skin Care / Q000379:methods / Q000451:nursing; D013577:Syndrome; D013921:Thrombocytopenia / Q000139:chemically induced / Q000517:prevention & control; D016896:Treatment Outcome; D014357:Trypsin / Q000737:chemistry / Q000627:therapeutic use*; D014945:Wound Healing
chemical_list: D000925:Anticoagulants; D001453:Balsams; D004338:Drug Combinations; D009824:Ointments; D002368:Castor Oil; C025080:Peruvian balsam; D006493:Heparin; D014357:Trypsin