Can hormesis be a default for dose-response?
Since the 1920s, interest in hormesis has peaked and ebbed. Hormesis had been a forgotten theory until recent investigation by Dr Ed Calabrese at the University of Massachusetts, along with others, resurrected it from obscurity. This renewed interest is demonstrated by recent articles in prestigious scientific journals such as Nature and Science as well as the popular press (Discovery, US News and World Report and newspapers such as the Boston Globe). Currently, a strong interest in this theory of dose-response (which predicts contrasting effects at low versus high doses) exists and is explored in this issue.
Callahan
Barbara G
BG
Department of Public Health, Environmental Health Sciences Concentration, N233 Morrill Science Center I, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003-9298, USA. bgc@schoolph.umass.edu
D004305:Dose-Response Relationship, Drug; D006801:Humans; D016014:Linear Models; D019055:No-Observed-Adverse-Effect Level