Symptoms of anxiety and depression in family members of intensive care unit patients before discharge or death. A prospective multicenter study.
OBJECTIVE
More than two thirds of family members visiting intensive care unit (ICU) patients have symptoms of anxiety or depression during the first days of hospitalization. Identifying determinants of these symptoms would help caregivers support families at patient discharge or when death is imminent.


METHODS
Prospective multicenter study including 78 ICUs (1184 beds) in France.


METHODS
Family members completed the Hospital Anxiety and Depression Scale on the day of patient discharge or death to allow evaluation of the prevalence and potential factors associated with symptoms of anxiety and depression.


RESULTS
Three hundred fifty-seven patients were included in the study, and 544 family members completed the Hospital Anxiety and Depression Scale. Symptoms of anxiety and depression were found in 73.4% and 35.3% of family members, respectively; 75.5% of family members and 82.7% of spouses had symptoms of anxiety or depression (P = .007). Symptoms of depression were more prevalent in family members of nonsurvivors (48.2%) than of survivors (32.7%) (P = .008). The multivariate model identified 3 groups of factors associated with symptoms: (1) patient-related: severity as assessed by the Simplified Acute Physiology Score II (odds ratio [OR] 1.017 per point) and patient age (OR 0.984 per year) predicted anxiety, and Simplified Acute Physiology Score II (OR, 1.015 per point), patient death (OR 2.092), and patient age (OR 0.981) predicted depression; (2) family-related: the spouse predicted anxiety (OR 2.085); and (3) ICU-related: a room with more than 1 bed (OR 1.539) predicted depression.


CONCLUSIONS
The prevalence of symptoms of anxiety and depression remains high at the end of the ICU stay, whether the patient is well enough to be discharged or is near death.
Pochard
Frédéric
F
Intensive Care Unit of the Saint Louis Teaching Hospital and University of Paris, France.
Darmon
Michaël
M
Fassier
Thomas
T
Bollaert
Pierre-Edouard
PE
Cheval
Christine
C
Coloigner
Madeleine
M
Merouani
Asri
A
Moulront
Serge
S
Pigne
Etienne
E
Pingat
Juliette
J
Zahar
Jean-Ralph
JR
Schlemmer
Benoît
B
Azoulay
Elie
E
D000328:Adult; D000367:Age Factors; D000368:Aged; D001007:Anxiety / Q000453:epidemiology* / Q000523:psychology; D003643:Death; D003863:Depression / Q000453:epidemiology* / Q000523:psychology; D005190:Family / Q000523:psychology*; D006801:Humans; D007362:Intensive Care Units; D008875:Middle Aged; D010351:Patient Discharge; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index