Effects of zinc supplementation in patients with type 1 diabetes.
The purpose of this study was to identify the effect of oral zinc supplementation in patients with type 1 diabetes (T1DM) on metabolic control and zinc blood concentrations. The sample consisted of 20 patients with T1DM and a control group (n=17). Metabolic control was evaluated by glycemia at fast, 24 h glycosuria, and HbA1c. Zinc concentrations were measured in plasma and erythrocytes. After the first collection of biological material, oral zinc supplementation was initiated and continued for 4 mo in T1MD patients (T1). Daily dosages were established based on Dietary Recommended Intakes (DRIs), considering zinc intake based on data from other studies previously performed with this population. All analyses were repeated after supplementation (T2). Metabolic control was unsatisfactory, with an HbA1c increase at T2. There was no difference in zinc concentrations in plasma and erythrocytes between patients with T1DM and control. Zinc concentrations in plasma were within the normal range in T1MD before and after supplementation and the control. Zinc concentrations in erythrocyte presented lower than normal values for all groups. A zinc increase in erythrocyte after supplementation was observed in T1DM patients, although without statistical significance. More studies are needed to confirm oral zinc supplementation as nutritional management in diabetes.
de Sena
Karine Cavalcanti Mauricio
KC
Department of Nutrition, Universidade Federal do Rio Grande do Norte, UFRN, Av. Cordeiro de Farias s/n- Petrópolis, Natal-RN, 59010-180, Brazil.
Arrais
Ricardo Fernando
RF
das Graças Almeida
Maria
M
de Araújo
Dina Maria
DM
dos Santos
Mirza Medeiros
MM
de Lima
Vanessa Teixeira
VT
de Fãtima Campos Pedrosa
Lucia
L
D000284:Administration, Oral; D000293:Adolescent; D015415:Biomarkers / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D019587:Dietary Supplements; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006029:Glycosuria / Q000378:metabolism; D006801:Humans; D007223:Infant; D008297:Male; D013997:Time Factors; D015032:Zinc / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*
D015415:Biomarkers; D015032:Zinc