title: Study of osteointegration of a titanium prosthesis to the stapes: observations on an accidentally extracted stapes.
abstract: BACKGROUND
  Titanium is a well-established implant material, and its use in ossicular chain reconstruction during middle ear surgery is increasing.
  
  
  OBJECTIVE
  Bony fixation of titanium prostheses has to be considered using this material. Contact with bony structures of the middle ear may result in immobilization. In revision procedures, there is a potential risk of damaging or extracting adherent structures such as the stapes.
  
  
  METHODS
  This is a case report of an accidentally extracted stapes resulting from bony fixation of a titanium prosthesis in revision tympanoplasty. The surgical specimen was examined by microscopy, histology, and scanning electron microscopy. Energy dispersive x-ray analysis was used to confirm the elemental composition of the extracted stapes and the titanium prosthesis.
  
  
  RESULTS
  The prosthesis showed good biocompatibility at the implantation site, with signs of bone resorption of the stapes suprastructure. However, bony fixation of the undersurface of the prosthesis foot to the stapes footplate was confirmed by ultrastructural analysis.
  
  
  CONCLUSIONS
  In revision tympanoplasty, bony fixation of the titanium prosthesis should be considered.
authors: Department of Otorhinolaryngology, Head and Neck Surgery, St. Elisabeth Hospital, University of Bochum, Bochum, Germany. holger.sudhoff@rub.de
authors: Holger
authors: H
authors: Sudhoff
authors: Norbert
authors: N
authors: Lindner
authors: Jan
authors: J
authors: Gronemeyer
authors: Stefan
authors: S
authors: Dazert
authors: Henning
authors: H
authors: Hildmann
mesh_terms: D001301:Audiometry, Pure-Tone; D001862:Bone Resorption / Q000473:pathology; D020878:Device Removal / Q000009:adverse effects; D005260:Female; D006314:Hearing Loss, Conductive / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D016348:Osseointegration; D009998:Ossicular Prosthesis; D012086:Reoperation; D013052:Spectrometry, X-Ray Emission; D013199:Stapes / Q000473:pathology / Q000503:physiopathology*; D014025:Titanium; D014433:Tympanoplasty
chemical_list: D014025:Titanium