title: [Immunologic disorders in pathogenesis of chronic generalized parodontitis].
abstract: Systemic immunity was studied in patients with chronic generalized parodontitis. This group of patients had distinct changes in immunologic system: depression of T- and stimulation of B-cellular immunity without accumulation of plasma cells and initiation of effective humoral response. Increased peripheral blood number of lymphocytes expressing induction of apoptosis CD95 receptors and ligand for this receptor CD95L (Fas-L) can lead to intensification of lymphocyte apoptosis and may be the reason for T-cell deficit development. The results of the study confirm the important role of immune system disturbances in pathogenesis of chronic generalized parodontitis.
authors: A I
authors: AI
authors: Volozhin
authors: G V
authors: GV
authors: Poriadin
authors: T I
authors: TI
authors: Kazimiski
authors: G M
authors: GM
authors: Barer
authors: S Sh
authors: SSh
authors: Askerova
authors: Zh M
authors: ZhM
authors: Salmasi
mesh_terms: D017209:Apoptosis; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D053222:Fas Ligand Protein; D006801:Humans; D007109:Immunity; D008213:Lymphocyte Activation; D008562:Membrane Glycoproteins / Q000032:analysis; D010518:Periodontitis / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D019014:fas Receptor / Q000032:analysis
chemical_list: C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D019014:fas Receptor