Role of Na/K-ATPase in regulation of neurite growth in sensory neurons.
We studied the effects of acetylcholine and norepinephrine on the growth of neurites in organotypic culture of 10-12-day-old chick embryo sensory neurons. Acetylcholine (10(-8) M) and norepinephrine (10(-13) M) stimulated the growth on sensory neuron neurites. Experiments with combined application of acetylcholine and norepinephrine against the background of ouabain showed that the nonspecific action of the test neurotransmitters is related to modulation of Na/K-ATPase activity.
Penniyainen
V A
VA
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg. lev@infran.ru
Lopatina
E V
EV
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D016501:Neurites / Q000187:drug effects / Q000201:enzymology*; D009475:Neurons, Afferent / Q000187:drug effects / Q000201:enzymology*; D009638:Norepinephrine / Q000494:pharmacology; D010042:Ouabain / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism / Q000502:physiology*
D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase; D000109:Acetylcholine; D009638:Norepinephrine