Genetic prothrombotic risk factors in women with unexplained pregnancy loss.
BACKGROUND
Inherited thrombophilia has been associated with unexplained recurrent pregnancy loss (RPL) and stillbirth. This thrombotic tendency can manifest as thrombotic lesions in the placenta, and may lead to abortion and stillbirth. The aim of our case-control study was to investigate the prevalence of FVL and FII G20210A in women with adverse pregnancy outcome, compared to the prevalence of the same mutations in our health control group.


METHODS
102 consecutive women with unexplained pregnancy loss (55 with history of RPL, and 47 with history of stillbirth) were studied for hereditary thrombophilia. The health control group consisted of 217 healthy women from the general population.


CONCLUSIONS
Of the 55 women with recurrent abortions, we found the same prevalence for the FVL and the FII G20210A(9.1%, 5 pts). (p=NS compared to control group). Of the 47 women with stillbirth, 11 (23.4%) had the FVL and 9 (19.1%) had the FII G20210A(p<0.0005 for both mutations). In our experience the prevalence of FVL and the FII G20210Amutations was significantly higher in women with unexplained stillbirth, instead the prevalence of genetic thrombophilia was high but not statistically significant in women with recurrent pregnancy loss.
Sottilotta
Gianluca
G
Centro Emofilia-Servizio Emostasi e Trombosi, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria, Italy. giasotti@tin.it
Oriana
Vincenzo
V
Latella
Caterina
C
Luise
Francesca
F
Piromalli
Angela
A
Ramirez
Francesca
F
Mammì
Corrado
C
Santoro
Rita
R
Iannaccaro
Piergiorgio
P
Muleo
Gaetano
G
Lombardo
Vincenzo Trapani
VT
D000026:Abortion, Habitual / Q000453:epidemiology / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics; D005260:Female; D006801:Humans; D009154:Mutation; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology / Q000235:genetics*; D015995:Prevalence; D011516:Prothrombin / Q000235:genetics*; D012189:Retrospective Studies; D012307:Risk Factors; D050497:Stillbirth; D019851:Thrombophilia / Q000150:complications* / Q000235:genetics*
C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin