title: [Landiolol does not affect bispectral index scale in off-pump coronary artery bypass surgery in patients under fast-track cardiac anesthesia].
abstract: BACKGROUND
  We evaluated the effect of landiolol, a novel ultra-short-acting receptor-selective blocker, on bispectral index scale (BIS).
  
  
  METHODS
  Ten patients scheduled for off-pump coronary artery bypass (OPCAB) surgery under fast-track cardiac anesthesia were analyzed. Anesthesia was maintained with appropriate additional administration of fentanyl (total dose: 10-15 microg x kg(-1)) and vecuronium under inhalation of a mixture of oxygen, air and sevoflurane (less than 2%). Landiolol was administered continuously for 5 min, when the heart rate (HR) was 80 or more per minute and the BIS values were kept between 40-60. HR, mean arterial pressure (MAP), cardiac index (CI) and BIS values were recorded at 4 time points (after induction of anesthesia, before administration of landiolol, immediately before comple- tion of administration, and 15 minutes after completion of administration).
  
  
  RESULTS
  HR decreased significantly by landiolol administration, but there were no significant changes in MAP, CI and BIS.
  
  
  CONCLUSIONS
  This study suggests that landiolol does not affect BIS in OPCAB surgery patients under fast-track cardiac anesthesia.
authors: Department of Anesthesiology, Faculty of Medicine, Oita University, Oita.
authors: Norihisa
authors: N
authors: Yasuda
authors: Koji
authors: K
authors: Goto
authors: Junya
authors: J
authors: Kusaka
authors: Akira
authors: A
authors: Hasegawa
authors: Seigo
authors: S
authors: Hidaka
authors: Takaaki
authors: T
authors: Kitano
authors: Hideo
authors: H
authors: Iwasaka
authors: Takayuki
authors: T
authors: Noguchi
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D047549:Coronary Artery Bypass, Off-Pump; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009025:Morpholines / Q000494:pharmacology*; D014508:Urea / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D009025:Morpholines; C077049:landiolol; D014508:Urea