Cholinopositive effect of dilept (neurotensin peptidomimetic) as the basis of its mnemotropic effect.
Dilept eliminated learning disturbances in the extrapolation avoidance test, caused by chronic injections of scopolamine alone and in combination with madopar to rats. Dilept improved the dynamics of training and parameters of spatial memory impaired by olfactory bulbectomy (operation causing hypofunction of the central cholinergic system). The detected choline-positive effect of dilept together with pronounced dopaminergic activity necessitate its further development as a drug effective in positive and negative symptoms of schizophrenia and psychotic manifestations of Alzheimer's disease.
Ostrovskaya
R U
RU
V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow. rita_o@postman.ru
Retyunskaya
M V
MV
Bondarenko
N A
NA
Gudasheva
T A
TA
Bobkova
N V
NV
Samokhin
A N
AN
D000544:Alzheimer Disease / Q000188:drug therapy; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001545:Benserazide / Q000494:pharmacology; D004338:Drug Combinations; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D018727:Muscarinic Antagonists / Q000494:pharmacology; D009496:Neurotensin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D009830:Olfactory Bulb / Q000601:surgery; D010455:Peptides / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D011976:Receptors, Muscarinic / Q000187:drug effects; D012559:Schizophrenia / Q000188:drug therapy; D012601:Scopolamine / Q000494:pharmacology; D013028:Space Perception / Q000187:drug effects
D004338:Drug Combinations; D018727:Muscarinic Antagonists; D010455:Peptides; D011976:Receptors, Muscarinic; C005177:benserazide, levodopa drug combination; D009496:Neurotensin; D007980:Levodopa; D001545:Benserazide; D012601:Scopolamine