title: Atrophic tongue associated with Candida.
abstract: BACKGROUND
  Traditionally, total atrophic tongue has been due to nutritional deficiencies, such as vitamin B12, folic acid, or iron deficiencies, and partial atrophic tongue has been well known as median rhomboid glossitis or geographic tongue. The other cause of atrophic tongue is oral candidiasis.
  
  
  METHODS
  Forty patients with atrophic change of the tongue were examined on a relation to candidiasis. All of them complained of tongue pain on spicy or hot diet. Laboratory examinations included blood examination for diabetes and anemia, culture test and direct cytologic examination. The intensity of tongue pain was evaluated pre- and post-treatment using visual analogue scale (VAS).
  
  
  RESULTS
  Twenty-four of 40 (60%) had pre-disposing factors of candidiasis including diabetes mellitus, malignancy, systemic steroid therapy, long-term antibiotic therapy and others in their medical history. Blood examinations revealed mild anemia and/or Fe deficiency in 5 (12.5%), mild diabetes in 4 (10.0%), both in two, while residual 29 patients (72.5%) were within reference levels. In the culture examination, candidal species were isolated in 72.5%, and almost all of them were candida albicans. The direct cytologic examination performed in 17 of 40 patients, witch revealed pseudohyphae of fungi in 14 patients (82.4%). After the antifungal treatment, the tongue pain disappeared or improved markedly in 80%. Simultaneously, the regenerative tendency of filifolm papilla of the tongue dorsum was observed in these patients.
  
  
  CONCLUSIONS
  Atrophic tongue associated with pain at eating, even though it is mild atrophic change, has a high probability of being a candida-induced lesion. Long disease duration and no benefit by topical steroids are suggestive and diagnostic factors of this disease.
authors: Department of Oral Surgery, Osaka Medical College, Osaka, Japan. ora007@poh.osaka-med.ac.jp
authors: Haruhiko
authors: H
authors: Terai
authors: Masashi
authors: M
authors: Shimahara
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000627:therapeutic use; D001284:Atrophy; D002180:Candidiasis, Oral / Q000150:complications* / Q000188:drug therapy; D005260:Female; D005929:Glossitis, Benign Migratory / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D008297:Male; D008825:Miconazole / Q000627:therapeutic use; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D014059:Tongue / Q000473:pathology; D016896:Treatment Outcome; D014806:Vitamin B 12 Deficiency / Q000150:complications
chemical_list: D000935:Antifungal Agents; D008825:Miconazole