[Summarization in the research of canstatin].
Canstatin protein, a newly found angiogenesis inhibitor, has powerful anti-angiogenesis effect. Canstatin is the N terminal fragment of collagen IV alpha2 chain NC1 domain. Its distinct anti-cancer effect in mouse model and low toxicity has not only made it a promising new anti-cancer drug candidate, but also drawn much attention of researchers. The detection, denomination, biological characters and mechanism of canstatin protein, and also the prospect of its application were summarized.
Li
Yuying
Y
Institute of Respiratory Disease, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China. lzhlyyhy@163.com
Qian
Guisheng
G
Huang
Guijun
G
D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D024141:Collagen Type IV / Q000494:pharmacology*; D006801:Humans; D051379:Mice
D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D024141:Collagen Type IV