[Increased bleeding tendency induced by beta-lactam antibiotics].
Bleeding induced by beta-lactam antibiotics was reported for the first time in 1970. The phenomenon has been confirmed in subsequent studies but has never resulted in any general recommendations for, e.g., screening and treatment. Over a period of seven months, we diagnosed in our department three cases of presumed beta-lactam-induced bleeding in patients treated with high-dose penicillin for endocarditis and septic shock.
Mellerup
Martin T
MT
Klinisk-Biokemisk Afdeling, Amtssygehuset i Gentofte, Københavns Amts Trombosecenter. mame@gentoftehosp.kbhamt.dk
Bruun
Niels Eske
NE
Nielsen
Jørn Dalsgaard
JD
D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004697:Endocarditis, Bacterial / Q000188:drug therapy; D005839:Gentamicins / Q000008:administration & dosage / Q000009:adverse effects*; D006470:Hemorrhage / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010406:Penicillins / Q000008:administration & dosage / Q000009:adverse effects*; D012772:Shock, Septic / Q000188:drug therapy; D047090:beta-Lactams / Q000008:administration & dosage / Q000009:adverse effects*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010406:Penicillins; D047090:beta-Lactams