Primary cutaneous nocardiosis in 2 patients on immunosuppressants.
Two female cases of primary cutaneous nocardiosis due to Nocardia brasiliensis are described. The first was associated with polymyositis and the second with chronic immune thrombocytopenic purpura. Both patients had received corticosteroids. In both cases the responsible actinomycetes were sensitive to trimethoprim/sulfamethoxazole. This drug was administered to both patients with excellent results. Treatment was continued for 3 months to prevent recurrence, a common consequence of short-term therapy. N. brasiliensis should be included in the differential diagnosis of any case of nodular lymphangitis, especially in immunocompromized patients.
Kofteridis
Diamantis
D
Department of Internal Medicine, University Hospital of Heraklion, 710 03, Heraklion, Crete, Greece.
Mantadakis
Elpis
E
Mixaki
Ioanna
I
Stefanidou
Maria
M
Maraki
Sofia
S
Alexandrakis
Michael
M
Samonis
George
G
D000900:Anti-Bacterial Agents; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008727:Methotrexate / Q000009:adverse effects; D008875:Middle Aged; D009617:Nocardia Infections / Q000209:etiology*; D017285:Polymyositis / Q000188:drug therapy; D011239:Prednisolone / Q000009:adverse effects; D011241:Prednisone / Q000009:adverse effects; D011696:Purpura, Thrombocytopenic / Q000188:drug therapy; D017192:Skin Diseases, Bacterial / Q000188:drug therapy / Q000209:etiology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D011239:Prednisolone; D011241:Prednisone; D008727:Methotrexate