Peripheral T-cell lymphoma together with myelofibrosis with elevated plasma transforming growth factor-beta1.
Myelofibrosis is usually observed in myeloproliferative disorders, such as chronic myeloid leukemia. However, there are only a few reports showing an association between T-cell lymphoma and myelofibrosis. We report a case of peripheral T-cell lymphoma, unspecified (diffuse large cell) type, involving the bone marrow that was associated with severe myelofibrosis. In the present case, the plasma concentration of transforming growth factor-beta1 (TGF-beta1) was increased to 8.95 ng/ml (normal range: 1.56-3.24 ng/ml). No lymphadenopathy or skin lesions were observed during the entire clinical course. Although the mechanism of secondary myelofibrosis is still unclear, elevated plasma TGF-beta1 might be involved in the pathogenesis of bone marrow fibrosis in the present case.
Okabe
Seiichi
S
First Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan.
Miyazawa
Keisuke
K
Iguchi
Tomotaka
T
Sumi
Masahiko
M
Takaku
Tomoiku
T
Ito
Yoshikazu
Y
Kimura
Yukihiko
Y
Serizawa
Hiromi
H
Mukai
Kiyoshi
K
Ohyashiki
Kazuma
K
D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D016411:Lymphoma, T-Cell, Peripheral / Q000097:blood / Q000150:complications* / Q000628:therapy; D008297:Male; D055728:Primary Myelofibrosis / Q000097:blood / Q000150:complications* / Q000473:pathology; D016212:Transforming Growth Factor beta / Q000032:analysis*; D053773:Transforming Growth Factor beta1
C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1