title: Information technologies for vaccine research.
abstract: Vaccinology is a combinatorial science which studies the diversity of pathogens and the human immune system, and formulations that can modulate immune responses and prevent or cure disease. Huge amounts of data are produced by genomics and proteomics projects and large-scale screening of pathogen-host and antigen-host interactions. Current developments in computational vaccinology mainly support the analysis of antigen processing and presentation and the characterization of targets of immune response. Future development will also include systemic models of vaccine responses. Immunomics, the large-scale screening of immune processes which includes powerful immunoinformatic tools, offers great promise for future translation of basic immunology research advances into successful vaccines.
authors: Institute for Infocomm Research, 21 Heng Mui Keng Terrace, 119613, Singapore. vladimir@i2r.a-star.edu.sg
authors: Vladimir
authors: V
authors: Brusic
authors: J Thomas
authors: JT
authors: August
authors: Nikolai
authors: N
authors: Petrovsky
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods* / Q000639:trends; D006801:Humans; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000639:trends; D014612:Vaccines / Q000235:genetics / Q000627:therapeutic use*
chemical_list: D014612:Vaccines