Testicular chloroma in a nonleukemic infant.
Extramedullary myeloid cell tumors (EMCT) are localized collections of immature myeloid cells that occur outside of the bone marrow. Usually observed concurrently with bone marrow disease, EMCT also may occur in the absence of overt marrow leukemia. In this report, we describe an infant with a testicular mass that was identified as an EMCT after orchiectomy. Unlike the only previously reported case of infantile testicular chloroma, this patient did not exhibit bone marrow disease at diagnosis. Because systemic chemotherapy is considered to be superior to local control (surgery, radiation therapy), the patient was treated with intensively timed induction chemotherapy followed by 3 cycles of maintenance treatment (according to CCG protocol #2891) but no radiation therapy. The patient remains disease-free 18 months after diagnosis.
Armstrong
Michael B
MB
Department of Pediatrics, Section of Pediatric Hematology-Oncology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA. armstrng@med.umich.edu
Nafiu
Olubukola O
OO
Valdez
Riccardo
R
Park
John M
JM
Williams
James A
JA
Wechsler
Daniel S
DS
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male; D023981:Sarcoma, Myeloid / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D013736:Testicular Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D016896:Treatment Outcome
D000970:Antineoplastic Agents