Retrovirus reverse transcriptases containing a modified YXDD motif.
The YXDD motif, where X is a variable amino acid, is highly conserved among various viral RNA-dependent DNA polymerases. Mutations in the YXDD motif can abolish enzymatic activity, alter the processivity and fidelity of enzymes and decrease virus infectivity. This review provides a summary of the significant documented studies on the YXDD motif of HIV-1, simian immunodeficiency virus, feline immunodeficiency virus and murine leukaemia virus and the impact of mutation that this motif has had on viral pathogenesis and drug treatment.
Sharma
Prem L
PL
Laboratory of Biochemical Pharmacology and Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Nurpeisov
Viktoria
V
Schinazi
Raymond F
RF
D020816:Amino Acid Motifs; D017124:Conserved Sequence; D004351:Drug Resistance; D006801:Humans; D012194:RNA-Directed DNA Polymerase / Q000737:chemistry* / Q000235:genetics; D012190:Retroviridae / Q000201:enzymology*; D014779:Virus Replication
D012194:RNA-Directed DNA Polymerase