title: Moraxella catarrhalis is only a weak activator of the mannose-binding lectin (MBL) pathway of complement activation.
abstract: A hemolytic bystander assay was used to assess the functional serum mannose-binding lectin (MBL) activating capacity of five isolates of Moraxella catarrhalis obtained from children who suffered recurrent acute otitis media episodes. Results showed that this organism is only a poor activator of the lectin pathway of complement activation, with subsequent consequences for the etiology of otitis media by this organism.
authors: Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands. j.hays@erasmusmc.nl
authors: John P
authors: JP
authors: Hays
authors: Alewijn
authors: A
authors: Ott
authors: Cees M
authors: CM
authors: Verduin
authors: Alex
authors: A
authors: van Belkum
authors: Saskia
authors: S
authors: Kuipers
mesh_terms: D002648:Child; D037582:Complement Pathway, Mannose-Binding Lectin; D006801:Humans; D037601:Mannose-Binding Lectin / Q000097:blood*; D001936:Moraxella catarrhalis / Q000502:physiology*; D010033:Otitis Media / Q000382:microbiology*; D013045:Species Specificity
chemical_list: D037601:Mannose-Binding Lectin