[The antitumor effects of total-flavonoid from Stellera chamaejasmel].
OBJECTIVE
To study the antitumor effects of total-flavonoid from S. chamaejasmel.


METHODS
The in vitro antitumor activity against human cancer cell lines, such as stomach cancer SGC-7901, hepatocarcinoma BEL-7402 and leukemia HL-60, were determined by a MTT and clone formation assay. The in vivo antitumor activity was evaluated by the antitumor bioassay against transplanted mouse solid tumor S180 and H22.


RESULTS
The total-flavonoid inhibited cell proliferation of human tumor cell lines, and its activities are higher than that of vincristine. The total-flavonoid also showed a lower acute toxicity and the strong antitumor activity against transplanted mouse solid tumor S180 and H22 in vivo showing a positive correlation with the concentration. The inhibitory rates at the dose of 0.10 g x kg(-1) ip against S180 and H22 are 45.64% and 47.59%, respectively.


CONCLUSIONS
The total-flavonoid from S. chamaejasme has antitumor activities in vivo and in vitro.
Wang
Minn
M
Lanzhou Medical College, Lanzhou 730000, China.
Jia
Zheng-Ping
ZP
Ma
Jun
J
Wang
Bin
B
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005419:Flavonoids / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D010946:Plants, Medicinal / Q000737:chemistry; D012510:Sarcoma 180 / Q000473:pathology*; D013274:Stomach Neoplasms / Q000473:pathology; D029645:Thymelaeaceae / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids