Molecular pharmacology of gonadotropins.
Gonadotropins have been studied in biological systems for decades and many of their properties are well defined. These include pharmacological properties such as affinity, stability, and pharmacokinetics also used to characterize drugs. Technologies applied to research on gonadotropins have led to the creation of hormone analogs with alterations to one or more of these proper-ties. Some of these analogs have potential therapeutic applications. A challenge to realizing this potential is the accurate prediction of how these compounds will perform in humans. This could be facilitated by advances in biological models and the understanding of specific effects of the hormones on their receptors.
Campbell
Robert K
RK
Serono Research Institute, Rockland, MA 02370, USA. robert.campbell@serono.com
D001682:Biological Availability; D015195:Drug Design; D005640:Follicle Stimulating Hormone / Q000493:pharmacokinetics* / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007986:Luteinizing Hormone / Q000493:pharmacokinetics* / Q000494:pharmacology* / Q000627:therapeutic use
D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone