title: Growth hormone benefits children with 18q deletions.
abstract: Most individuals with constitutional deletions of chromosome 18q have developmental delays, dysmyelination of the brain, and growth failure due to growth hormone deficiency. We monitored the effects of growth hormone treatment by evaluating 23 individuals for changes in growth, nonverbal intelligence quotient (nIQ), and quantitative brain MRI changes. Over an average of 37 months, the treated group of 13 children had an average nIQ increase of 17 points, an increase in height standard deviation score of 1.7, and significant change in T1 relaxation times in the caudate and frontal white matter. Cognitive changes of this magnitude are clinically significant and are anticipated to have an effect on the long-term outcomes for the treated individuals.
authors: Department of Pediatrics, University of Texas Health Science Center, San Antonio, 78229, USA. cody@uthscsa.edu
authors: Jannine D
authors: JD
authors: Cody
authors: Margaret
authors: M
authors: Semrud-Clikeman
authors: L Jean
authors: LJ
authors: Hardies
authors: Jack
authors: J
authors: Lancaster
authors: Patricia D
authors: PD
authors: Ghidoni
authors: Rebecca L
authors: RL
authors: Schaub
authors: Nora M
authors: NM
authors: Thompson
authors: Lynda
authors: L
authors: Wells
authors: John E
authors: JE
authors: Cornell
authors: Tanzy M
authors: TM
authors: Love
authors: Peter T
authors: PT
authors: Fox
authors: Robin J
authors: RJ
authors: Leach
authors: Celia I
authors: CI
authors: Kaye
authors: Daniel E
authors: DE
authors: Hale
mesh_terms: D000015:Abnormalities, Multiple / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D001827:Body Height / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D002872:Chromosome Deletion; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics*; D002658:Developmental Disabilities / Q000188:drug therapy / Q000473:pathology; D006130:Growth Disorders / Q000188:drug therapy / Q000473:pathology; D019382:Human Growth Hormone / Q000172:deficiency / Q000627:therapeutic use*; D006801:Humans; D007360:Intelligence / Q000187:drug effects; D008279:Magnetic Resonance Imaging; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D019382:Human Growth Hormone