Interaction of cells with L-lactide/glycolide copolymers synthesized with the use of tin or zirconium compounds.
Comparative studies have been carried out on the viability of cells culture and production of collagen on lactide/glycolide copolymers synthesized using zirconium or tin initiators. Cell response of various cell types: fibroblast-like cells, osteoblast-like cells, monocyte/macrophage-like cells has been examined. Cell response depends on the kind of cells and the initiator used during the synthesis of the polymer. In a number of cases the cells grown on materials containing zirconium have been reported to have better survival (for example, Saos2 cells). An enhanced collagen production on these copolymers has been also observed.
Czajkowska
Barbara
B
Department of Immunology, Collegium Medicum of the Jagiellonian University, Cracow, Poland.
Dobrzynski
Piotr
P
Bero
Maciej
M
D001672:Biocompatible Materials / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D003094:Collagen / Q000096:biosynthesis*; D006801:Humans; D019344:Lactic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011100:Polyglycolic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017971:Tin Compounds / Q000737:chemistry*; D020298:U937 Cells; D015040:Zirconium / Q000737:chemistry*
D001672:Biocompatible Materials; D017971:Tin Compounds; D011100:Polyglycolic Acid; D019344:Lactic Acid; D003094:Collagen; D015040:Zirconium