Synthesis of sterically hindered peptide analogs using diphenyl phosphite as the coupling reagent.
Some model sterically hindered peptide analogs were synthesized with various yields using diphenyl phosphite as the coupling reagent under mild conditions. The experimental procedure is straightforward and the products are easily isolated. This method may be convenient and efficient for the synthesis of hindered peptides.
Yang
Ting
T
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
Lin
Changxue
C
Fu
Hua
H
Jiang
Yuyang
Y
Zhao
Yufen
Y
D000596:Amino Acids / Q000737:chemistry; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D063065:Organophosphonates; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000596:Amino Acids; D007202:Indicators and Reagents; D063065:Organophosphonates; D010455:Peptides; C507805:diphenyl phosphite