title: Relationship between antitumor efficiency of photodynamic therapy with photoditasine and photoenergy density.
abstract: We studied the effect of photodynamic therapy with photoditasine at different protocols of photoenergy exposure on morphofunctional parameters of M-1 sarcoma. It was found that proliferative activity of tumor cells (evaluated by immunostaining for PCNA) nonlinearly decreases after exposure to 150, 300, and 600 J/cm2. The main form of cell death during the early period after photodynamic therapy was direct photocoagulation necrosis caused by destruction of sensitized cell structures and ischemic necrosis developing as a result of alteration of vascular network in the tumors. Photoenergy density was not essential for the intensity of induced apoptosis.
authors: Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk, Russia. y_romanko@hotmail.com
authors: Yu S
authors: YS
authors: Romanko
authors: A F
authors: AF
authors: Tsyb
authors: M A
authors: MA
authors: Kaplan
authors: V V
authors: VV
authors: Popuchiev
mesh_terms: D000818:Animals; D008297:Male; D008536:Meglumine / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D051381:Rats; D012513:Sarcoma, Experimental / Q000188:drug therapy*
chemical_list: D017319:Photosensitizing Agents; D008536:Meglumine