title: [Structure charateristics of mitoxantrone transforsomes].
abstract: This study sought to clarify the molecular location and the interaction between mitoxantrone and mitoxantrone transforsomes. The anthraquinone of mitoxantrone, a heterocyclic ring that intercalates in the lipid of bilayer, was determined by UV-spectrophotometry and electron probes scan microscopy. Two aminoethylamino side-chains of the drugs fit to the phosphates of lecithin were determined by 8-value, thus the interaction with lecithin was substantiated. Differential scanning calorimetry confirmed that mitoxantrone has remarkable stabilizing effect on the mitoxantrone transforsomes membrane. The mitoxantrone binds tightly to lecithin. So a high degree of encapsulation efficiency and the sustained-release character of mitoxantrone transforsomes are verified.
authors: Department of Pharmaceutics Sciences, School of Pharmacy, Sichuan University, Chengdu 610041, China.
authors: Tong
authors: T
authors: Chen
authors: Shixiang
authors: S
authors: Hou
authors: Biqiong
authors: B
authors: Shi
authors: Yu
authors: Y
authors: Zheng
authors: Yiyi
authors: Y
authors: Sun
authors: Yunfei
authors: Y
authors: Tian
mesh_terms: D000880:Anthraquinones / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D003692:Delayed-Action Preparations / Q000737:chemistry; D054709:Lecithins / Q000737:chemistry; D008942:Mitoxantrone / Q000737:chemistry*; D013053:Spectrophotometry
chemical_list: D000880:Anthraquinones; D003692:Delayed-Action Preparations; D054709:Lecithins; C042834:9,10-anthraquinone; D008942:Mitoxantrone