[Immunohistochemical analysis of epidermal growth factor receptors expression in malignant ovarian tumors].
OBJECTIVE
To study the frequency of EGFR expression in patients having malignant and benign ovarian tumors and to analyze its relation to some clinico-pathological factors.


METHODS
In a prospective study 71 patients with malignant and 19 with benign ovarian tumors were included for the period 1999-2004. We utilized immunohistochemical analysis with monoclonal mouse antihuman EGFR antibody and EGFR pharm Dx kit (DAKO).


RESULTS
The frequency of EGFR expression for the malignant ovarian tumours was 62.9% compared to 36.8% for the benign ones (p = 0.042). The patients with peritoneal washing positive for tumour cells and those with progressing cancer express EGFR significantly more frequently, 77% and 75%, respectively (p = 0.05).


CONCLUSIONS
Malignant ovarian tumours have significantly greater frequency of EGFR expression compared to benign ovarian tumours.
Tomov
S
S
Popovska
S
S
Veselinova
T
T
Gorchev
G
G
Velkova
A
A
D000230:Adenocarcinoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D018572:Disease-Free Survival; D066246:ErbB Receptors / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D011446:Prospective Studies
D014408:Biomarkers, Tumor; D066246:ErbB Receptors