title: Food avoidance behavior to dietary octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) exposure in the northern bobwhite (Colinusvirginianus).
abstract: High-melting explosive (HMX; octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine) is a widely utilized explosive component of munitions used by the military. Consequently, production and use through testing and training at military installations has resulted in deposition of HMX in soil. Since these areas are often used by birds, the oral toxicity of HMX exposure to northern bobwhite (Colinus virginianus) was evaluated. Attempts to determine the acute lethal dose were unsuccessful. Initially, 8 birds (1 male/1 female per dose group) were orally dosed at levels ranging from 125 to 2125 mg HMX/kg body weight. A single death at the midrange resulted in subsequent trials of oral doses up to 10,760 mg/kg body weight. Only a single death occurred at 7173 mg/kg. A subsequent 28-d feeding study was then conducted to evaluate the potential for toxicity resulting from repetitive oral exposures. Northern bobwhite were exposed to concentrations of HMX in feed of either 10000, 1000, 100, or 0 mg/kg. These exposures resulted in a clear concentration-related reduction in feed consumption and body mass. Reductions in egg production in females were correlated with changes in body mass and feed consumption. Other physiological indicators were consistent with a considerable reduction in feed intake. These results suggest that HMX concentration is responsible for intense feed aversion behavior and thus not likely a factor that would appreciably contribute to risk for wild birds at military ranges.
authors: US Army Center for Health Promotion and Preventative Medicine, Health Effects Research Program, Aberdeen Proving Ground, Maryland 21010-5403, USA. Mark.S.Johnson@us.army.mil
authors: Mark S
authors: MS
authors: Johnson
authors: Robert M
authors: RM
authors: Gogal
authors: Calvert T
authors: CT
authors: Larsen
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001392:Azocines / Q000008:administration & dosage / Q000633:toxicity*; D003088:Colinus; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D006573:Heterocyclic Compounds, 1-Ring / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D010063:Ovum / Q000187:drug effects; D012989:Soil Pollutants / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D001392:Azocines; D006573:Heterocyclic Compounds, 1-Ring; D012989:Soil Pollutants; C007950:octogen