Systemic interleukin-10 concentrations do not alter between the first and second trimester in normal pregnancy.
BACKGROUND
Interleukin 10 (IL-10) is involved in normal fecundity and systemic IL-10 changes during gestation might reflect an immunologic shift at the maternal-fetal interface.


METHODS
Serum IL-10 levels were measured in the first and second trimester of uncomplicated pregnancy in 32 women. The low interassay coefficient of variation of the low adjustor of the IL-10 assay (5.2%) enabled us to detect IL-10 concentrations between 0.50 pg/ml and 4.0 pg/ml.


RESULTS
There was no statistically significant difference between serum IL-10 levels in the first trimester (median 1.10; range 0.53-4.60 pg/ml) and second trimester (median 1.05; range 0.64-3.30 pg/ml).


CONCLUSIONS
IL-10 is not systemically activated to a detectable degree between the first and second trimester of normal pregnancy.
van der Weiden
R M F
RM
Department of Obstetrics and Gynecology, Sint Franciscus Gasthuis, Kleiweg 500, 3045, Rotterdam, The Netherlands. rmfvdwei@knmg.nl
Janssen
J W
JW
Stegeman
M
M
D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D011247:Pregnancy / Q000097:blood / Q000502:physiology*; D011261:Pregnancy Trimester, First / Q000097:blood / Q000502:physiology; D011262:Pregnancy Trimester, Second / Q000097:blood / Q000502:physiology
D016753:Interleukin-10