Global regulation of gene expression by ArlRS, a two-component signal transduction regulatory system of Staphylococcus aureus.
Staphylococcus aureus expresses various cell wall-associated and extracellular virulence factors, coordinately controlled by different two-component signal transduction systems and transcriptional regulators. In this study, we used microarray technology to identify the genes regulated by ArlR. The microarray data indicate that ArlR functions as a positive regulator and also as a negative repressor to directly and/or indirectly mediate the expression of at least 114 genes involved in different functions, including autolysis, cell division, growth, and pathogenesis.
Liang
Xudong
X
Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Ave., St. Paul, MN 55108, USA.
Zheng
Li
L
Landwehr
Christina
C
Lunsford
Dwayne
D
Holmes
David
D
Ji
Yinduo
Y
D001426:Bacterial Proteins / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial; D011494:Protein Kinases / Q000235:genetics*; D018085:Regulon; D015398:Signal Transduction / Q000235:genetics*; D013211:Staphylococcus aureus / Q000235:genetics
C411334:ArlR protein, Staphylococcus aureus; D001426:Bacterial Proteins; D011494:Protein Kinases; C411333:ArlS protein, Staphylococcus aureus