Osteolytic potential of triphenyl bismuth as an alternative contrast medium in acrylic bone cement.
Radiopaque cement containing barium sulfate causes significantly more bone resorption in vivo and in vitro than radiolucent cement. The aim of this study was to investigate the osteolytic potential of an alternative radiopaque agent, triphenyl bismuth (TPB). Bone cement particles containing various concentration of TPB (15 and 25 wt %) prepared by two methods, blending and dissolution, were added to monocytes in a bone resorption assay and the extent of lacunar resorption on dentine slices was determined. The results clearly show that cement particles containing TPB cause less bone resorption than cement particles containing barium sulfate. In addition, our results suggest that TPB prepared by dissolution in bone cement induces less osteolytic response than TPB-cement prepared by blending. The osteolysis in response to bone cement wear particles may therefore be reduced with TPB prepared using the blending technique.
Xu
Hu
H
Department of Orthopaedics, Xijing Hospital, Xi'an, China 710032.
Abdulghani
Saba
S
Behiri
John
J
Sabokbar
Afsie
A
D000818:Animals; D001862:Bone Resorption / Q000139:chemically induced* / Q000473:pathology; D002478:Cells, Cultured; D003287:Contrast Media / Q000009:adverse effects* / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D009000:Monocytes / Q000187:drug effects; D009942:Organometallic Compounds / Q000009:adverse effects*; D010010:Osteoclasts / Q000187:drug effects / Q000473:pathology; D010014:Osteolysis / Q000000981:diagnostic imaging / Q000473:pathology; D019904:Polymethyl Methacrylate / Q000009:adverse effects* / Q000737:chemistry*; D011859:Radiography; D013730:Terphenyl Compounds / Q000009:adverse effects*
D003287:Contrast Media; D009942:Organometallic Compounds; D013730:Terphenyl Compounds; D019904:Polymethyl Methacrylate; C076672:triphenyl bismuth