title: Limitations of apparent diffusion coefficient-based models in characterizing non-gaussian diffusion.
abstract: Diffusion in complex heterogeneous structures, for example, the neural fiber system, is non-gaussian. Recently, several methods have been introduced to address the issue of non-gaussian diffusion in multifiber systems. Some are based on apparent diffusion coefficient (ADC) analysis; and some are based on q-space analysis. Here, using a simple mathematic derivation, ADC-based models are shown to be mathematically self-inconsistent in the presence of non-gaussian diffusion. Monte Carlo simulation on restricted diffusion is applied to demonstrate the poor data fitting that can result from ADC-based models. Specific comparisons are performed between two generalized diffusion tensor imaging methods: one of them is based on ADC analysis, and the other is shown to be consistent with q-space formalism. The issue of imaging asymmetric microstructures is also investigated. Signal phase and spin exchange are necessary to resolve multiple orientations of an asymmetric structure.
authors: Lucas MRS/I Center, Department of Radiology, Stanford University, Stanford, California 94305-5488, USA.
authors: Chunlei
authors: C
authors: Liu
authors: Roland
authors: R
authors: Bammer
authors: Michael E
authors: ME
authors: Moseley
mesh_terms: D016880:Anisotropy; D003198:Computer Simulation; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D008962:Models, Theoretical; D009010:Monte Carlo Method; D019047:Phantoms, Imaging