title: Axillary recurrence after negative sentinel lymph node biopsy without axillary dissection: a study on 479 breast cancer patients.
abstract: OBJECTIVE
  To determine the axillary recurrence rate in breast cancer patients with negative sentinel lymph nodes (SLN) who did not undergo further axillary lymph node dissection (ALND), and to establish whether this conservative axillary approach leads to an increased recourse to diagnostic axillary biopsy during the follow-up period because of the clinical suspicion of nodal recurrence.
  
  
  METHODS
  In 479 patients, operated on for early breast cancer between 1998 and 2002 in five institutions, SLN biopsy was negative and no further axillary surgery was performed. SLN was localized using subdermal injection with 30-50 MBq of 99m-Tc-colloidal albumin. Follow-up controls were performed at 6-monthly intervals.
  
  
  RESULTS
  The mean number of SLNs removed was 1.4 per patient. Most patients (90.6%) were given adjuvant systemic therapy, based on the primary tumour characteristics. At a median follow-up of 35.8 months, no clinical axillary recurrence was found. No patient underwent surgical axillary biopsy for suspicious clinical or ultrasonographic findings.
  
  
  CONCLUSIONS
  Our results confirm that SLN biopsy without ALND in SLN-negative patients with early breast cancer is not followed by clinically evident axillary recurrence in the short-term.
authors: Istituto Clinica Chirurgica II, University of Padova, Via Giustiniani 2, 35128 Padova, Italy. giorgio.zavagno@unipd.it
authors: G
authors: G
authors: Zavagno
authors: P
authors: P
authors: Carcoforo
authors: Z
authors: Z
authors: Franchini
authors: M
authors: M
authors: Renier
authors: L
authors: L
authors: Barutta
authors: G L
authors: GL
authors: De Salvo
authors: K
authors: K
authors: Maravegias
authors: G
authors: G
authors: Capitanio
authors: D
authors: D
authors: Nitti
authors: M
authors: M
authors: Lise
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001365:Axilla; D001943:Breast Neoplasms / Q000473:pathology*; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D021701:Sentinel Lymph Node Biopsy