[Correlation between increase of oxidative stress and microalbuminuria in type-1 diabetic patients].
Oxidative stress has an important role in genesis of diabetic complications, especially diabetic nephropathy. The aim of the study was to assess correlations between increase of oxidative stress (OS) and the development of microalbuminuria (MA) in type 1 diabetic patients. We determined the oxidative status by measuring the level of superoxide dismutase (SOD-Minanui method), catalase (CAT-Aebi method), glutathione peroxidase (GPx-Fukuzawa method) and glutathione (GSH-Ellman method) in 87 type 1 diabetic patients (44 with normal urinary protein excretion-group A and 43 with MA-group B) and 38 nondiabetic matched controls, before and 24 hours after a test effort. The results of the study point out that a decreased in activity of SOD or in levels of GSH is associated with an increased MA in type 1 diabetic patients.
Artenie
Anca
A
Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi, Clinica a IV-a Medicală Nefrologie.
Artenie
R
R
Ungureanu
Didona
D
Covic
A
A
D000328:Adult; D000419:Albuminuria / Q000209:etiology; D000465:Algorithms; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000201:enzymology* / Q000652:urine*; D003928:Diabetic Nephropathies / Q000201:enzymology* / Q000209:etiology / Q000652:urine*; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000097:blood; D013997:Time Factors
D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione