title: Co-deposition of amyloidogenic immunoglobulin light and heavy chains in localized pulmonary amyloidosis.
abstract: Localized pulmonary amyloidosis is a rare condition whose pathogenesis is insufficiently understood. In the present study, we report a case of localized pulmonary amyloidosis associated with lung-restricted lymphoplasmacytoid lymphoma, monoclonal for immunoglobulin (Ig) G lambda (lambda). Biochemical microtechniques have been applied for extraction, purification, and characterization of amyloid proteins. Surprisingly, chemical analysis of these proteins revealed a not-previously-described case of combined deposits containing Ig fragments of gamma heavy chain (variable domain) and lambda light chain (constant domain). In view of the absence of circulating monoclonal Ig, this case supports the hypothesis that localized amyloid is formed by local plasmacytoid cells.
authors: Heller Institute of Medical Research, Sheba Medical Center, Tel Hashomer, 52621, Israel. kaplanb@sheba.health.gov.il
authors: Batia
authors: B
authors: Kaplan
authors: Brian M
authors: BM
authors: Martin
authors: Olga
authors: O
authors: Boykov
authors: Rivka
authors: R
authors: Gal
authors: Mordechai
authors: M
authors: Pras
authors: Itzhak
authors: I
authors: Shechtman
authors: Milton
authors: M
authors: Saute
authors: Mordechai R
authors: MR
authors: Kramer
mesh_terms: D000368:Aged; D000682:Amyloid / Q000737:chemistry*; D000686:Amyloidosis / Q000150:complications / Q000473:pathology*; D015153:Blotting, Western; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000378:metabolism*; D007146:Immunoglobulin lambda-Chains / Q000378:metabolism*; D007150:Immunohistochemistry; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000473:pathology*; D008171:Lung Diseases / Q000150:complications / Q000473:pathology*; D008297:Male; D011014:Pneumonia / Q000473:pathology
chemical_list: D000682:Amyloid; D007143:Immunoglobulin Heavy Chains; D007146:Immunoglobulin lambda-Chains