Effect of gonadotropin-releasing-hormone-induced hypogonadism on insulin action as assessed by euglycemic clamp studies in men.
OBJECTIVE
In view of the relationship between hyperandrogenism and impaired insulin action in women with polycystic ovarian syndrome, we sought to investigate the effects of decreasing androgen levels on insulin action in men.


METHODS
Prospective clinical study.


METHODS
University hospital.


METHODS
Ten normal healthy men.


METHODS
GnRH agonist, 3.75 mg monthly for 3 months.


METHODS
Rate of glucose uptake, serum insulin, and glucose levels.


RESULTS
GnRH treatment caused a significant fall in circulating testosterone levels, from 572 +/- 58 ng/dL to 178 +/- 66 ng/dL (P<.05). However, as assessed by euglycemic hyperinsulinemic clamp studies, there was no significant change in glucose uptake.


CONCLUSIONS
In normal men, administration of a GnRH analogue was associated with a decrease in testosterone levels but not in insulin action.
Chauhan
Subodhsingh
S
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, West Virginia University-Charleston Division, Charleston, West Virginia, USA.
Diamond
Michael P
MP
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015309:Glucose Clamp Technique / Q000379:methods*; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D007006:Hypogonadism / Q000097:blood* / Q000139:chemically induced*; D007328:Insulin / Q000097:blood*; D008297:Male; D011446:Prospective Studies
D001786:Blood Glucose; D007328:Insulin; D007987:Gonadotropin-Releasing Hormone