title: Drosophila ATM and Mre11 are essential for the G2/M checkpoint induced by low-dose irradiation.
abstract: Others have suggested recently that the conserved ATM checkpoint kinase is minimally involved in controlling the G(2)/M checkpoint in Drosophila that serves to prevent mitotic entry in the presence of DNA damage. Our data indicate that both ATM and its regulator Mre11 are important for the checkpoint and that their roles become essential when animals are challenged with a low dose of X rays or when they have compromised checkpoint function of the ATM-related ATR kinase.
authors: Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
authors: Xiaolin
authors: X
authors: Bi
authors: Min
authors: M
authors: Gong
authors: Deepa
authors: D
authors: Srikanta
authors: Yikang S
authors: YS
authors: Rong
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics; D004307:Dose-Response Relationship, Radiation; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics*; D004706:Endodeoxyribonucleases / Q000235:genetics*; D018816:Genes, cdc; D008938:Mitosis / Q000235:genetics / Q000528:radiation effects*; D008957:Models, Genetic; D016296:Mutagenesis; D017346:Protein Serine-Threonine Kinases / Q000235:genetics
chemical_list: D018797:Cell Cycle Proteins; D029721:Drosophila Proteins; C444435:Mei-41 protein, Drosophila; D017346:Protein Serine-Threonine Kinases; D004706:Endodeoxyribonucleases; C492904:Mre11 protein, Drosophila