title: Effects of aerosolized class C fly ash in weanling goats.
abstract: OBJECTIVE
  To determine effects of repeated aerosol exposures to fly ash dust on respiratory tracts of tent-confined goats.
  
  
  METHODS
  12 weanling Boer-Spanish crossbred goats.
  
  
  METHODS
  Goats were randomly assigned to 2 groups: fly ash treatment group (principal goats, n = 6) or control group (control goats, 6). Aerosolized fly ash dust was provided during a 4-hour period for each of 6 applications given over 3 months and one 2-hour application prior to necropsy. Fly ash particle diameters ranged from 0.1 to 130 microm and averaged 17.8 microm, with 1.5% of fly ash particles in the 0.1- to 5-microm-diameter range. A mean +/- SD of 748 +/- 152 g/treatment was delivered inside a tent containing principal goats; control goats were placed inside a similar tent for 4-hour treatments without dust. Following treatment, rectal temperatures were taken at 0, 4, 6, 8, 24, and 72 hours; Hcts were recorded at 0, 24, and 72 hours.
  
  
  RESULTS
  Rectal temperatures were significantly increased at 4, 6, and 8 hours and decreased at 72 hours, compared with 0 hours. Mean +/- SEM Hct values were significantly increased for principal goats (3747 +/- 0.39%), compared with control goats (36.17 +/- 0.42%). A significant increase in the mean area of gross atelectatic lung lesions (1,410 mm2) was found in principal goats (n = 6), compared with control goats (440 mm2; 5).
  
  
  CONCLUSIONS
  An increase in atelectatic lung lesions was observed in principal goats, compared with control goats; however, overall, fly ash dust effects were nontoxic.
authors: USDA, Agricultural Research Science, Conservation, and Production Research Laboratory, PO Drawer 10, Bushland, TX 79012, USA.
authors: Charles W
authors: CW
authors: Purdy
authors: David C
authors: DC
authors: Straus
authors: J R
authors: JR
authors: Ayers
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002244:Carbon / Q000008:administration & dosage / Q000633:toxicity*; D060729:Coal Ash; D006041:Goats / Q000502:physiology*; D007958:Leukocyte Count / Q000662:veterinary; D008168:Lung / Q000473:pathology; D010316:Particle Size; D052638:Particulate Matter; D012137:Respiratory System / Q000187:drug effects*; D013997:Time Factors
chemical_list: D060729:Coal Ash; D052638:Particulate Matter; D002244:Carbon