Association between the GNB3 polymorphism and blood pressure in young Korean men.
OBJECTIVE
The purpose of the current study was to investigate the associations between the GNB3 C825T polymorphism, body fatness and fitness, and blood pressure in a sample of young Korean men.


METHODS
A total of 282 apparently healthy Korean men (nonobese N = 152, obese N = 130) aged 19-33 yr participated in the study. Body fatness and blood pressure were measured by using standardized protocols. The GNB3 C825T was genotyped by using polymerase chain reaction with restriction fragment length polymorphism.


RESULTS
Univariate analyses of variance and Bonferroni post hoc tests showed that in the obese group only, TT homozygotes had a lower VO2max (P = 0.015 and 0.043, respectively) but higher resting systolic (P = 0.025 and < 0.001, respectively) and mean arterial blood pressures (P = 0.049 and 0.002, respectively) than CC homozygotes or CT heterozygotes. We further investigated possible interactions between group and genotype and found a significant interaction in SBP only (P = 0.037) between the group and genotype, even when controlling for age, BMI, and VO2max as potential confounding factors. Stepwise regression analyses showed that body mass index and GNB3 genotype were two independent predictors for the variations in systolic blood pressure and heart rate up to by 14.3 and 14.5%, respectively. In addition, waist-to-hip ratio explained an individual variation in mean arterial pressure (MAP) up to by 11.2%.


CONCLUSIONS
The current findings of the study suggest that increased body fatness along with low cardiorespiratory fitness may magnify the genetic susceptibility of the GNB3 825T allele to elevated blood pressure in this study population.
Lee
Jiyoung
J
School of Sports Science, Sungkyunkwan University, Suwon, Kyonggi-do, Republic of Korea.
Lee
Sangho
S
Shin
Seonae
S
Kang
Hyun-Sik
HS
D000328:Adult; D000483:Alleles; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology*; D001823:Body Composition; D006339:Heart Rate; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D007723:Korea; D008297:Male; D010809:Physical Fitness; D011110:Polymorphism, Genetic
C454420:G-protein beta3 subunit; D020962:Heterotrimeric GTP-Binding Proteins