title: Tau suppression in a neurodegenerative mouse model improves memory function.
abstract: Neurofibrillary tangles (NFTs) are the most common intraneuronal inclusion in the brains of patients with neurodegenerative diseases and have been implicated in mediating neuronal death and cognitive deficits. Here, we found that mice expressing a repressible human tau variant developed progressive age-related NFTs, neuronal loss, and behavioral impairments. After the suppression of transgenic tau, memory function recovered, and neuron numbers stabilized, but to our surprise, NFTs continued to accumulate. Thus, NFTs are not sufficient to cause cognitive decline or neuronal death in this model of tauopathy.
authors: Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
authors: K
authors: K
authors: Santacruz
authors: J
authors: J
authors: Lewis
authors: T
authors: T
authors: Spires
authors: J
authors: J
authors: Paulson
authors: L
authors: L
authors: Kotilinek
authors: M
authors: M
authors: Ingelsson
authors: A
authors: A
authors: Guimaraes
authors: M
authors: M
authors: DeTure
authors: M
authors: M
authors: Ramsden
authors: E
authors: E
authors: McGowan
authors: C
authors: C
authors: Forster
authors: M
authors: M
authors: Yue
authors: J
authors: J
authors: Orne
authors: C
authors: C
authors: Janus
authors: A
authors: A
authors: Mariash
authors: M
authors: M
authors: Kuskowski
authors: B
authors: B
authors: Hyman
authors: M
authors: M
authors: Hutton
authors: K H
authors: KH
authors: Ashe
mesh_terms: D000375:Aging; D000818:Animals; D001284:Atrophy; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D003071:Cognition; D018450:Disease Progression; D004318:Doxycycline / Q000494:pharmacology; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology; D006801:Humans; D018782:Maze Learning; D008568:Memory; D051379:Mice; D008822:Mice, Transgenic; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D016874:Neurofibrillary Tangles / Q000378:metabolism / Q000473:pathology*; D009473:Neuronal Plasticity; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D009929:Organ Size; D010766:Phosphorylation; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012995:Solubility; D016875:tau Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D016875:tau Proteins; D004318:Doxycycline