Three new sesquiterpene hemiacetals from Achillea vermicularis.
Three new sesquiterpene hemiacetals, tentatively named as achilleanone (1), vermiculone (2) and vermicularone (3) have been isolated from Achillea vermicularis, along with three other known compounds beta-amyrin, oleonolic acid and beta-sitosterol. The structure elucidation of new compounds was based primarily on two-dimensional (2D) NMR techniques including Nuclear Overhauser Effect/Enhancement (NOE), heteronuclear multiple quantum coherence (HMQC), heteronuclear multiple bond correlation (HMBC) and nuclear overhauser effect spectroscopy (NOESY) experiments. Compounds 1, 2 and 3 have displayed inhibitory potential against lipoxygenase enzyme in a concentration-dependent fashion with promising IC50 values.
Ahmad
Viqar-Uddin
VU
International Center of Science, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan. vuahmad@cyber.net.pk
Farooq
Umar
U
Hussain
Javid
J
Farmanullah
Abbasi
Muhammad Athar
MA
Jassbi
Amir Reza
AR
Nawaz
Sarfraz Ahmad
SA
Choudhary
M Iqbal
MI
D031162:Achillea / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D004791:Enzyme Inhibitors; D016859:Lipoxygenase Inhibitors; D012717:Sesquiterpenes