title: [Accuracy of pulse contour cardiac index measurements during changes of preload and aortic impedance].
abstract: BACKGROUND
  Cardiac index obtained by arterial pulse contour analysis (CI(PC)) demonstrated good agreement with arterial or pulmonary arterial thermodilution derived cardiac index (CI(TD), CI(PA)) in cardiac surgical or critically ill patients. However as the accuracy of pulse contour analysis during changes of the aortic impedance is unclear, we compared CI(PC), CI(TD) and CI(PA) during changes of preload and the aortic impedance as occurring during sternotomy.
  
  
  METHODS
  CI(PC) und CI(TD), were compared in 28 patients, (and CI(PA) in 6 patients) undergoing elective coronary artery bypass grafting, before and after sternotomy. The relative changes DeltaCI(PC) und DeltaCI(PC) were calculated.
  
  
  RESULTS
  Sternotomy resulted in a significant increase in CI in 25 out of 28 patients. Regression analysis was performed between CI(PC) and CI(TD) before and after sternotomy (r(2) = 0.87, p<0.0001, r(2) = 0.88, p<0.0001) as well as between CI(PC) and CI(PA), before and after sternotomy (r(2) = 0.85, p<0.0001, r(2) = 0.93, p<0.01) and between DeltaCI(PC) and DeltaCI(TD) (r(2) = 0.72, p<0.0001). Bland Altman-Analysis for determining bias (m) and precision (2SD) between CI(PC) and CI(TD) before and after sternotomy and between DeltaCI(PC) and DeltaCI(TD) resulted in m = -0.03 L/min/m(2), 2SD = -0.34 to 0.28 L/min/m(2), m = -0.06 L/min/m(2), 2SD = -0.45 to 0.33 L/min/m(2) and m = -0.02 L/min/m(2), SD = -0.47 to 0.44 L/min/m(2).
  
  
  CONCLUSIONS
  Pulse contour analysis derived CI(PC) accurately reflects thermodilution derived CI(TD) or CI(PA) during changes of preload and the aortic impedance as occurring during sternotomy.
authors: Klinik und Poliklinik für Anästhesiologie, Universitätsklinikum Hamburg-Eppendorf. tfelbinger@uke.uni-hamburg.de
authors: T W
authors: TW
authors: Felbinger
authors: M S
authors: MS
authors: Goepfert
authors: T
authors: T
authors: Goresch
authors: A E
authors: AE
authors: Goetz
authors: D A
authors: DA
authors: Reuter
mesh_terms: D000368:Aged; D000465:Algorithms; D001011:Aorta / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology*; D002407:Catheterization, Swan-Ganz; D001026:Coronary Artery Bypass; D005260:Female; D006334:Heart Function Tests / Q000379:methods* / Q000706:statistics & numerical data; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D015203:Reproducibility of Results; D013815:Thermodilution; D014655:Vascular Resistance / Q000502:physiology