title: Dynamics and thermodynamics of dimerization of parallel G-quadruplexed DNA formed from d(TTAGn) (n=3-5).
abstract: Parallel G-quadruplexes formed from oligonucleotide sequences, d(TTAGn), where n = 3-5, have been shown to form a dimer through end-to-end stacking of 3'-terminal G-tetrads. The monomers and dimers of the G-quadruplexes are in dynamic equilibrium with an exchange rate of approximately 1 s-1. A thermodynamic study demonstrated that the dimerization of the G-quadruplexes is largely enthalpic in origin.
authors: Department of Chemistry, University of Tsukuba, Tsukuba 305-8571, Japan.
authors: Yoshitake
authors: Y
authors: Kato
authors: Takako
authors: T
authors: Ohyama
authors: Hajime
authors: H
authors: Mita
authors: Yasuhiko
authors: Y
authors: Yamamoto
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D019281:Dimerization; D054856:G-Quadruplexes; D006147:Guanine / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D013816:Thermodynamics
chemical_list: D006147:Guanine; D004247:DNA