title: Chiral oligomers by iterative tandem catalysis.
abstract: Iterative tandem catalysis is presented as a flexible tool for obtaining chiral macromolecules from racemic or prochiral monomers. Here, we combine lipase-catalyzed ring-opening of omega-substituted lactones with ruthenium-catalyzed racemization. In a two-pot system, enantioenriched oligomers of 6-methyl-epsilon-caprolactone were synthesized, which could not have been obtained by enzymatic ring-opening alone. A one-pot experiment proved highly promising in developing a novel route toward enantiopure polyesters.
authors: Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands.
authors: Bart A C
authors: BA
authors: van As
authors: Jeroen
authors: J
authors: van Buijtenen
authors: Andreas
authors: A
authors: Heise
authors: Quirinus B
authors: QB
authors: Broxterman
authors: Gerard K M
authors: GK
authors: Verzijl
authors: Anja R A
authors: AR
authors: Palmans
authors: E W
authors: EW
authors: Meijer