Structural biology of glycoprotein hormones and their receptors.
Glycoprotein hormones regulate reproduction in vertebrates and exert their actions through specific G protein-coupled receptors on target cell surfaces. Structural information is now available for human chorionic gonadotropin (CG), follicle-stimulating hormone (FSH), and FSH bound to the extracellular binding domain of its receptor (FSHR(HB)). The recently determined structure of a human FSH-FSHR(HB) complex provides an explanation for the specificity of glycoprotein hormones binding to their receptors, and it suggests hypotheses concerning the mechanism of transmembrane signal transduction.
Fan
Qing R
QR
Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA.
Hendrickson
Wayne A
WA
D000818:Animals; D006063:Chorionic Gonadotropin / Q000737:chemistry / Q000378:metabolism; D005640:Follicle Stimulating Hormone / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D017434:Protein Structure, Tertiary / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry* / Q000378:metabolism*; D011967:Receptors, Gonadotropin / Q000737:chemistry* / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D013329:Structure-Activity Relationship
D006063:Chorionic Gonadotropin; D043562:Receptors, G-Protein-Coupled; D011967:Receptors, Gonadotropin; D005640:Follicle Stimulating Hormone