CD44-v6 concentrations in carcinoma of the uterine cervix: lack of prognostic significance.
Several kinds of cellular adhesion molecules, like different splicing variants of CD 44, have gained important as prognostic or markers for metastatic disease. Fresh frozen samples from 64 cervical carcinoma (CX) were stored in liquid nitrogen and examined using ELISA-technique, testing the prognostic impact. Normal cervical tissue served as control. CD 44-v6 concentration, was significant elevated in tumor tissue, when compared to the controls (P=0.04). There was no correlation to tumor stage (P=0.61), lymphovascular space involvement (P=0.075) or pelvic lymph node involvement (P=0.81). The CD 44-v6 concentration was not informative regarding recurrence-free and overall survival. Contrary to immunohistochemistry, the quantification of CD 44-v6 using ELISA-technique does not provide any further information.
Horn
L-C
LC
Institute of Pathology (Division of Gynecologic Pathology), University of Leipzig, Liebigstrasse 26, Leipzig, 04103, Germany. hornl@medizin.uni-leipzig.de
Raptis
G
G
Fischer
U
U
Hentschel
B
B
Köhler
U
U
Richter
C E
CE
Martin
R
R
D002448:Cell Adhesion; D005260:Female; D006023:Glycoproteins / Q000032:analysis*; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis*; D008198:Lymph Nodes / Q000378:metabolism; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000473:pathology*
C112697:CD44v6 antigen; D006023:Glycoproteins; D018960:Hyaluronan Receptors