Effect of opioids on mechanoreflexive respiration control.
The effects of opioids (morphine and fentanyl) on the function of mechanoreceptive respiration regulatory loop were demonstrated. In most opioid-treated rats (74% cases) vagotomy was followed by apneustic respiration with inspiration pause. Excess of opioids in rat CNS produced minor disturbances in the respiration rhythm, but in the absence afferent input from the mechanoreceptors of respiratory pathways and lungs, pronounced periodic apneustic respiration with inspiration pauses developed. The opioidergic system is involved in the formation of respiratory rhythm, but had no appreciable effect on transmission of mechanoreceptive nerve pulses from respiratory pathways and the lungs to the respiratory center.
Tarakanov
I A
IA
Institute of General Pathology and Pathological Physiology, Russian Academy of Medical Sciences, Moscow. inspiration@mtu-net.ru
Tikhomirova
L N
LN
Safonov
V A
VA
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D005283:Fentanyl / Q000494:pharmacology*; D009020:Morphine / Q000494:pharmacology*; D051381:Rats; D012018:Reflex / Q000187:drug effects*; D012119:Respiration / Q000187:drug effects*; D014628:Vagotomy
D000701:Analgesics, Opioid; D009020:Morphine; D005283:Fentanyl