The chemistry and biology of mucin-type O-linked glycosylation.
Mucin-type O-linked glycosylation is a fundamental post-translational modification that is involved in a variety of important biological processes. However, the lack of chemical tools to study mucin-type O-linked glycosylation has hindered our molecular understanding of O-linked glycans in many biological contexts. The review discusses the significance of mucin-type O-linked glycosylation initiated by the polypeptide N-acetylgalactosaminyltransferases in biology and development of chemical tools to study these enzymes and their substrates.
Hang
Howard C
HC
Department of Chemistry, University of California, Berkeley 94720-1460, USA. hao_hang@hms.harvard.edu
Bertozzi
Carolyn R
CR
D002240:Carbohydrate Sequence; D006031:Glycosylation; D008969:Molecular Sequence Data; D009077:Mucins / Q000737:chemistry* / Q000378:metabolism; D017350:N-Acetylgalactosaminyltransferases / Q000378:metabolism; D011134:Polysaccharides / Q000096:biosynthesis; D011487:Protein Conformation
D009077:Mucins; D011134:Polysaccharides; D017350:N-Acetylgalactosaminyltransferases