5'-Homoneplanocin A inhibits hepatitis B and hepatitis C.
As an outgrowth of our program to develop an efficient synthesis of 5'-homoneplanocin A, its antiviral potential was explored beyond that already in the literature. From that, this compound was found to have meaningful activity toward hepatitis B and hepatitis C, which represents an example of one agent effective toward both viruses. These data and an improved preparation of 5'-homoneplanocin A are reported.
Yang
Minmin
M
Department of Chemistry and Biochemistry, Chemistry Building, Auburn University, Auburn, Alabama 36849-5312, USA.
Schneller
Stewart W
SW
Korba
Brent
B
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D016174:Hepacivirus / Q000187:drug effects* / Q000502:physiology; D006515:Hepatitis B virus / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D013237:Stereoisomerism; D014779:Virus Replication / Q000187:drug effects
C502995:5'-homoneplanocin; D000998:Antiviral Agents; D000241:Adenosine