HTR2A: association and expression studies in neuropsychiatric genetics.
Over the last decade the gene encoding 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) has been implicated as a functional candidate in many neuropsychiatric phenotypes including: schizophrenia, attention deficit hyperactivity disorder (ADHD), affective disorders, eating disorders, anxiety disorders, obsessive-compulsive disorder, suicide and Alzheimer's disease (AD). Different studies have tested for genetic association (case-control and family-based studies), protein expression (receptor binding assays), transcriptional expression (mRNA assays) and allelic expression. In this review we examine and summarize these findings in various neuropsychiatric phenotypes.
Norton
Nadine
N
Department of Psychological Medicine, Henry Wellcome Building, Wales School of Medicine, Heath Park, Cardiff CF14 4XN, UK. nortonn@cf.ac.uk
Owen
Michael J
MJ
D000544:Alzheimer Disease / Q000235:genetics; D000818:Animals; D001008:Anxiety Disorders / Q000235:genetics; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics; D002986:Clinical Trials as Topic; D001068:Feeding and Eating Disorders / Q000235:genetics; D006801:Humans; D001523:Mental Disorders / Q000235:genetics* / Q000378:metabolism; D019964:Mood Disorders / Q000235:genetics; D044402:Receptor, Serotonin, 5-HT2A / Q000378:metabolism*; D012559:Schizophrenia / Q000235:genetics; D012701:Serotonin / Q000378:metabolism*; D013405:Suicide
D044402:Receptor, Serotonin, 5-HT2A; D012701:Serotonin