title: [Synthesis and antibacterial activity of 3-(5-substituted phenyl-[1,3,4] oxadiazole-2-yl-methylenethio)-5-pyridin-3-yl-[1,2,4] triazole-4-yl-amines].
abstract: OBJECTIVE
  To study on synthesis and antibacterial activity evaluation of polyheterocycles.
  
  
  METHODS
  The condensation of 4-amino-3-pyridin-3-yl-4H-[1,2,4] triazole-5-thiol with 2-chloromethyl-5-substituted phenyl-[1,3,4] oxadiazoles gave the corresponding title heterocycle amines, and the in vitro antibacterial activity was primarily evaluated by the method of cup-plate diffusion solution.
  
  
  RESULTS
  Twelve novel compounds were synthesized, and their structures were confirmed by IR, 1H NMR, MS and element analysis. Biological screening results demonstrated that most of the compounds prepared showed good antibacterial activity.
  
  
  CONCLUSIONS
  Oxadiazoles incorporting pyridyl triazole ring may be a pharmacophor structure in the molecule for developing antibacterial candidate drugs.
authors: College of Pharmacy of Henan University, Kaifeng 475004, China. hgqxy@sina.com.cn
authors: Guo-qiang
authors: GQ
authors: Hu
authors: Song-qiang
authors: SQ
authors: Xie
authors: Qiu-ju
authors: QJ
authors: Xu
authors: Wen-long
authors: WL
authors: Huang
authors: Hui-bin
authors: HB
authors: Zhang
authors: Sheng-tang
authors: ST
authors: Huang
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011514:Proteus vulgaris / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D010069:Oxadiazoles; D014230:Triazoles