Polymorphisms in the DBH and DRD2 gene regions and smoking behavior.
The DRD2 TaqI A and DBH-1021 C/T polymorphisms were genotyped in smoking alcoholics (N = 100), non-alcoholic smokers (N = 120) and nonsmoking controls (N = 112). Alcoholic and non-alcoholic smokers presented a higher frequency of the DRD2 TaqI A1 allele (P = 0.04) than non-smoking controls. Individuals who had at least one DBH-1021 T allele smoked fewer cigarettes per day than CC homozygotes (P = 0.03). These results are coherent with the expected effects of these polymorphisms on dopaminergic function.
Freire
Maria Teresa M V
MT
Departamento de Genética , Instituto de Biociências, UFRGS, Av. Bento Gonçalves, 9500, Porto Alegre, RS, 91501-970, Brazil.
Marques
Francine Z C
FZ
Hutz
Mara H
MH
Bau
Claiton H D
CH
D000328:Adult; D000437:Alcoholism / Q000235:genetics; D000483:Alleles; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D015897:Comorbidity; D004299:Dopamine beta-Hydroxylase / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012907:Smoking / Q000235:genetics*; D019914:Taq Polymerase / Q000235:genetics
D017448:Receptors, Dopamine D2; D004299:Dopamine beta-Hydroxylase; D019914:Taq Polymerase