title: Beyond methotrexate: biologic therapy in rheumatoid arthritis.
abstract: Biologics have revolutionised the treatment of RA due to their efficacy, speed of onset and tolerability. Increasing evidence suggests that early intervention is the key to combating RA. The future challenge is to find the best time to introduce biologics into the treatment paradigm in the hope of inducing disease remission--something unthinkable even a decade ago.
authors: Department of Rheumatology, Addenbrooke's Hospital, Cambridge.
authors: Andrew J
authors: AJ
authors: Ostör
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy*; D001691:Biological Therapy / Q000379:methods; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use*; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D018501:Antirheumatic Agents; D017472:Receptors, Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D008727:Methotrexate