Consecutive organ transplantation in inbred rats: long-term results--Are organs recyclable?
Using 9-12-month-old Lewis rats, our laboratory performed consecutive organ transplantations to assess the technical feasibility and observe the histopathologies of prolonged transplants and implants over a rat's life span. This study includes a total of 688 cases of consecutive syngeneic organ transplantation, including pancreaticoduodenum (PD), en-bloc liver-pancreaticoduodenum-spleen-stomach (LPdSpSt), and spleen bearing ovary or testicle. A 52-month-old consecutively transplanted pancreas showed normal acini and islet cells. Consecutively transplanted LPdSpSt cases at 25-28 months preserved normal histology. After 26.5 months of ovarian follicle implantation into the spleen, the pathology of the organ exhibited typical dysgerminoma. However, 29.5-month-old infantile testicle implants in the spleen showed seminoma. Our studies suggest that transplanted organs can be reusable and retransplanted, and we hope this could be one of the clues to solve donor-organ shortages in the future.
Lee
Sun
S
San Diego Microsurgical Institute, Scripps Mercy Hospital, San Diego, CA 92103, USA. msurgical@yahoo.com
Hong
In C
IC
Yoo
Chang H
CH
Nam
Sam
S
Bai
Sammy
S
Pivetti
Christopher
C
Kim
Kenny K
KK
Emmanuel
Greg
G
Kim
Jason J
JJ
D'Silva
Milbhor
M
Wang
Yuquin
Y
Nozawa
Masumi
M
Lee
Donna
D
Niewiadomski
S
S
Yoon
Jin H
JH
Jung
Se I
SI
Wolf
Paul
P
Gittes
Ruben F
RF
D000818:Animals; D016377:Organ Transplantation / Q000379:methods* / Q000502:physiology; D051381:Rats; D011917:Rats, Inbred Lew; D012086:Reoperation; D014019:Tissue Donors / Q000600:supply & distribution*