Analgesic activity of 5-HT3 receptor antagonists.
The effects of 5-HT3 receptor antagonists tropisetron and condensed derivative of benzimidazole (laboratory code 64B) on nociceptive threshold were examined on models with activation of peripheral and central nociceptive mechanisms. The examined substances demonstrated pronounced analgesic effects in peripheral pain.
Spasov
A A
AA
Department of Pharmacology, Volgograd State Medical University, Russia. farm@interdacom.ru
Chernikov
M V
MV
Kiabiya
S T
ST
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D008297:Male; D017288:Pain Threshold / Q000187:drug effects; D051381:Rats; D058831:Serotonin 5-HT3 Receptor Antagonists; D012702:Serotonin Antagonists / Q000494:pharmacology*
D000700:Analgesics; D058831:Serotonin 5-HT3 Receptor Antagonists; D012702:Serotonin Antagonists