Hepatotoxicity associated with the use of a fixed combination of chloroquine and proguanil.
Here we report on a case of hepatotoxicity associated with the use of a fixed combination of chloroquine and proguanil. Alternative causes of liver injury were excluded. The pathophysiological mechanism remains unclear, with a possibility of allergic reaction. In view of the widespread use of both drugs, clinicians should be aware of this drug-induced liver injury.
Wielgo-Polanin
R
R
Centre Régional de Pharmacovigilance, Service de Pharmacologie et Toxicologie, CHU d'Angers, 4 rue Larrey, 49933 Angers Cedex 9, France.
Lagarce
L
L
Gautron
E
E
Diquet
B
B
Lainé-Cessac
P
P
D016907:Adverse Drug Reaction Reporting Systems; D000962:Antimalarials / Q000008:administration & dosage / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D002738:Chloroquine / Q000009:adverse effects* / Q000494:pharmacology; D004338:Drug Combinations; D004347:Drug Interactions; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000517:prevention & control; D008875:Middle Aged; D002727:Proguanil / Q000009:adverse effects* / Q000494:pharmacology
D000962:Antimalarials; D004338:Drug Combinations; D002738:Chloroquine; D002727:Proguanil