[Correlation between platelet count and CA-125 in ovarian cancer].
OBJECTIVE
To determine whether a correlation between platelet count and CA-125 exists, and to compare the mean levels of CA-125 in groups with normal and elevated platelet counts.


METHODS
A retrospective analysis of the medical records concerning to 31 ovarian cancer inpatients, treated 1998-2002 with primary surgery and subsequent platinum-based chemotherapy at the Division of Gynecology, Department of Perinatology and Gynecology, University Medical School Poznań.


METHODS
137 serum and whole blood samples collected from 31 ovarian cancer patients during their consecutive hospital stays.


RESULTS
There was a positive, moderate (r = 0.49) and highly significant (p < 0.0000001) correlation between platelet count and CA-125 levels. Thrombocytosis occurred in 45% patients before treatment, and in none when the 6th course of chemotherapy was given. In the thrombocytosis group, an average CA-125 level (913.5 U/ml) was significantly higher (p < 0.00001) then in the group with normal platelet count (103.7 U/ml).


CONCLUSIONS
Platelet count and CA-125 levels do correlate in blood samples taken from ovarian cancer patients at the same time.
Friebe
Zbigniew
Z
Klinika Ginekologii Katedry Perinatologii i Ginekologii Akademii Medycznej, Poznaniu.
Watrowski
Rafał
R
Bembnista
Maciej
M
Rokowska
Anita
A
Włosiińska
Joanna
J
Dembińska
Małgorzata
M
D000328:Adult; D000368:Aged; D018394:CA-125 Antigen / Q000097:blood*; D005260:Female; D006801:Humans; D008499:Medical Records; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000097:blood* / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D010976:Platelet Count; D011044:Poland; D012189:Retrospective Studies; D012307:Risk Factors; D013922:Thrombocytosis / Q000188:drug therapy / Q000276:immunology*
D018394:CA-125 Antigen