title: A poor response to proton pump inhibition is not a contraindication for laparoscopic antireflux surgery for gastro esophageal reflux disease.
abstract: BACKGROUND
  We aimed to determine if a poor response to proton pump inhibitors (PPIs) can predict a poor outcome following laparoscopic antireflux surgery (LARS) in our surgically treated population.
  
  
  METHODS
  A total of 324 patients undergoing LARS were included in this study. Following standardized assessment, patients recorded the efficacy of their medication on visual analogue scales. Pre- and postoperative symptom scores were recorded, with outcomes measured by modified Visick scores.
  
  
  RESULTS
  There were 233 good responders (>50% relief) and 91 poor responders (<49% relief). Both groups demonstrated a significant decline in postoperative symptom scores. Ninety-four percent of good responders had an excellent or good outcome, compared to 87% of poor responders. Twenty-seven patients reported a fair or poor outcome, despite improved postoperative symptom scores. Fifteen of these patients reported continuing heartburn; five had positive pH tests.
  
  
  CONCLUSIONS
  Our results do not support the assumption that a poor response to PPIs equates to a poor outcome after LARS.
authors: Department of Laparoscopic and Upper GI Surgery, Royal Berkshire Hospital, London Road, Reading RG1 5AN, England, UK. PMWilkerson@aol.com
authors: P M
authors: PM
authors: Wilkerson
authors: J
authors: J
authors: Stratford
authors: L
authors: L
authors: Jones
authors: J
authors: J
authors: Sohanpal
authors: M I
authors: MI
authors: Booth
authors: T C B
authors: TC
authors: Dehn
mesh_terms: D000328:Adult; D000075202:Contraindications; D005260:Female; D005500:Follow-Up Studies; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D054328:Proton Pump Inhibitors
chemical_list: D054328:Proton Pump Inhibitors