title: Hemolytic activity of new linear surfactin analogs in relation to their physico-chemical properties.
abstract: New linear analogs of surfactin have been synthesized. Their physico-chemical parameters were determined. The results indicate that these linear products show surface activities although they are lowered compared to those of cyclic compounds. The hemolytic activities have also been assayed. In contrast with cyclic surfactins, no significant hemolysis occurs for the linear products in the range of concentrations tested. Moreover, a protective effect against Triton X-100 induced hemolysis has been highlighted for linear surfactins. The concentration at which this protective effect happens is correlated directly to the CMC, and inversely to the acyl chain length of the product. In a hypotonic medium, analogs having a long acyl chain tend to increase the hemolysis, meanwhile the product with the shortest chain tends to decrease it.
authors: Unité de chimie biologique industrielle, Faculté universitaire des sciences agronomiques de Gembloux, 2, passage des déportés, Gembloux 5030, Belgium. dufour.s@fsagx.ac.be
authors: Samuel
authors: S
authors: Dufour
authors: Magali
authors: M
authors: Deleu
authors: Katherine
authors: K
authors: Nott
authors: Bernard
authors: B
authors: Wathelet
authors: Philippe
authors: P
authors: Thonart
authors: Michel
authors: M
authors: Paquot
mesh_terms: D006461:Hemolysis / Q000187:drug effects*; D007700:Kinetics; D055666:Lipopeptides; D017830:Octoxynol; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000494:pharmacology; D013501:Surface-Active Agents / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D055666:Lipopeptides; D010456:Peptides, Cyclic; D013501:Surface-Active Agents; C009365:surfactin peptide; D017830:Octoxynol