title: An iterative catalytic route to enantiopure deoxypropionate subunits: asymmetric conjugate addition of grignard reagents to alpha,beta-unsaturated thioesters.
abstract: A highly enantioselective (up to 96% ee) conjugate addition of Grignard reagents, in particular, MeMgBr, to alpha,beta-unsaturated thioesters is provided as well as its application to a diastereo- and enantioselective iterative route to syn- and anti-1,3-dimethyl arrays and deoxypropionate subunits. The versatility of the method is illustrated in the synthesis of (-)-lardolure, a multimethyl-branched insect natural pheromone.
authors: Department of Organic Chemistry and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
authors: Renaud
authors: R
authors: Des Mazery
authors: Maddalena
authors: M
authors: Pullez
authors: Fernando
authors: F
authors: López
authors: Syuzanna R
authors: SR
authors: Harutyunyan
authors: Adriaan J
authors: AJ
authors: Minnaard
authors: Ben L
authors: BL
authors: Feringa