[Analysis on processing mechanism of calamine].
OBJECTIVE
To study processing method and mechanism of Calamine.


METHODS
Thermogravimetry analysis method and nano-technology were adopted to analyze and synthesize the components in Calamine, Tetracycline was took as the comparison drug to determine the antibacterial activity of Calamine and its components.


RESULTS
A part of zinc carbonate in Calamine was decomposed into zinc oxide when processing, and the particle size was smaller than before. The antibacterial activity of Calamine is decided by the content and particle size of zinc oxide, and has nothing with zinc carbonate. The more content and the smaller particle size of zinc oxide, the more powerful antibacterial activity of Calamine.


CONCLUSIONS
The content and the particle size of zinc oxide can be the important targets in the processing of Calamine.
Guo
Yi-Ming
YM
Peoples Hospital of Jilin Province, Changchun 130012, China.
Yu
Kai-Feng
KF
Liu
Yan-Hua
YH
Zhao
Jing-Zhe
JZ
Wang
Zi-Cheng
ZC
Zhang
Heng-Bin
HB
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002254:Carbonates / Q000737:chemistry / Q000494:pharmacology; D004338:Drug Combinations; D004926:Escherichia coli / Q000187:drug effects; D005290:Ferric Compounds / Q000737:chemistry* / Q000494:pharmacology; D008419:Materia Medica / Q000737:chemistry / Q000494:pharmacology*; D049329:Nanostructures; D036103:Nanotechnology; D010316:Particle Size; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012475:Salmonella / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects*; D013678:Technology, Pharmaceutical / Q000379:methods*; D013752:Tetracycline / Q000494:pharmacology; D013818:Thermogravimetry; D017967:Zinc Compounds / Q000737:chemistry / Q000494:pharmacology; D015034:Zinc Oxide / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D002254:Carbonates; D004338:Drug Combinations; D005290:Ferric Compounds; D008419:Materia Medica; D017967:Zinc Compounds; C020241:calamine (pharmaceutical preparation); C036650:zinc carbonate; D013752:Tetracycline; D015034:Zinc Oxide