title: Safety review of kava (Piper methysticum) by the Natural Standard Research Collaboration.
abstract: This systematic review discusses the proposed uses, dosing parameters, adverse effects, toxicology, interactions and mechanism of action of kava. The widespread concern regarding the potential hepatotoxicity of kava is discussed. A recommendation is made to consolidate and analyse available reports and to continue postmarket surveillance in an international repository to prevent duplicates and promote collection of thorough details at the time of each report so that any association with kava is clearly defined.
authors: Natural Standard Research Collaboration, 1 Broadway, 14th Floor, Cambridge, MA 02142, USA. Info@naturalstandard.com
authors: Catherine
authors: C
authors: Ulbricht
authors: Ethan
authors: E
authors: Basch
authors: Heather
authors: H
authors: Boon
authors: Edzard
authors: E
authors: Ernst
authors: Paul
authors: P
authors: Hammerness
authors: David
authors: D
authors: Sollars
authors: Candy
authors: C
authors: Tsourounis
authors: Jen
authors: J
authors: Woods
authors: Stephen
authors: S
authors: Bent
mesh_terms: D003625:Data Collection; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006801:Humans; D020901:Kava / Q000009:adverse effects* / Q000737:chemistry*; D028321:Plant Preparations / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D028321:Plant Preparations