Improved naming after TMS treatments in a chronic, global aphasia patient--case report.
We report improved ability to name pictures at 2 and 8 months after repetitive transcranial magnetic stimulation (rTMS) treatments to the pars triangularis portion of right Broca's homologue in a 57 year-old woman with severe nonfluent/global aphasia (6.5 years post left basal ganglia bleed, subcortical lesion). TMS was applied at 1 Hz, 20 minutes a day, 10 days, over a two-week period. She received no speech therapy during the study. One year after her TMS treatments, she entered speech therapy with continued improvement. TMS may have modulated activity in the remaining left and right hemisphere neural network for naming.
Naeser
Margaret A
MA
Harold Goodglass Boston University Aphasia Research Center, Department of Neurology, Boston University School of Medicine and the Veterans Affairs Boston Healthcare System, Boston, Massachusetts 02130, USA. mnaeser@bu.edu
Martin
Paula I
PI
Nicholas
Marjorie
M
Baker
Errol H
EH
Seekins
Heidi
H
Helm-Estabrooks
Nancy
N
Cayer-Meade
Carol
C
Kobayashi
Masahito
M
Theoret
Hugo
H
Fregni
Felipe
F
Tormos
Jose Maria
JM
Kurland
Jacquie
J
Doron
Karl W
KW
Pascual-Leone
Alvaro
A
D001037:Aphasia / Q000534:rehabilitation / Q000628:therapy*; D001479:Basal Ganglia / Q000473:pathology / Q000528:radiation effects; D002908:Chronic Disease; D004558:Electric Stimulation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008280:Magnetics; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D010364:Pattern Recognition, Visual / Q000502:physiology / Q000528:radiation effects*; D013070:Speech Therapy / Q000379:methods; D013997:Time Factors