title: [Immunohistochemical analysis of epidermal growth factor receptors expression in malignant ovarian tumors].
abstract: OBJECTIVE
  To study the frequency of EGFR expression in patients having malignant and benign ovarian tumors and to analyze its relation to some clinico-pathological factors.
  
  
  METHODS
  In a prospective study 71 patients with malignant and 19 with benign ovarian tumors were included for the period 1999-2004. We utilized immunohistochemical analysis with monoclonal mouse antihuman EGFR antibody and EGFR pharm Dx kit (DAKO).
  
  
  RESULTS
  The frequency of EGFR expression for the malignant ovarian tumours was 62.9% compared to 36.8% for the benign ones (p = 0.042). The patients with peritoneal washing positive for tumour cells and those with progressing cancer express EGFR significantly more frequently, 77% and 75%, respectively (p = 0.05).
  
  
  CONCLUSIONS
  Malignant ovarian tumours have significantly greater frequency of EGFR expression compared to benign ovarian tumours.
authors: S
authors: S
authors: Tomov
authors: S
authors: S
authors: Popovska
authors: T
authors: T
authors: Veselinova
authors: G
authors: G
authors: Gorchev
authors: A
authors: A
authors: Velkova
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D018572:Disease-Free Survival; D066246:ErbB Receptors / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D011446:Prospective Studies
chemical_list: D014408:Biomarkers, Tumor; D066246:ErbB Receptors