Synthesis and evaluation of antioxidative properties of a series of organoselenium compounds.
A series of organoselenocyanate compounds 4a-d were synthesized utilizing 1,8-naphthalic anhydride as the building unit. These compounds were evaluated for their antioxidative activities against DMBA-PMA-induced oxidative stress in a two-stage mouse skin carcinogenic model. Compound 4d was found to have the maximum antioxidative property in comparison with the other compounds. Also, the pretreatment group showed better results than the concomitant treatment groups.
Hossain
Sk Ugir
SU
Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, 37, SP Mukherjee Road, Kolkata 700 026, India.
Sengupta
Sumitra
S
Bhattacharya
Sudin
S
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D005260:Female; D015227:Lipid Peroxidation; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects; D016566:Organoselenium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment
D000975:Antioxidants; D016566:Organoselenium Compounds