title: Maternal serum soluble fms-like tyrosine kinase 1 concentrations are not increased in early pregnancy and decrease more slowly postpartum in women who develop preeclampsia.
abstract: OBJECTIVE
  We measured maternal serum soluble fms-like tyrosine kinase 1 concentrations across pregnancy and immediately postpartum in women who developed preeclampsia and normal pregnant women.
  
  
  METHODS
  This was a nested case control study of 113 normal pregnant women and 55 women with preeclampsia.
  
  
  RESULTS
  Serum soluble fms-like tyrosine kinase 1 concentrations increased similarly in early pregnancy in both groups. Mean serum soluble fms-like tyrosine kinase 1 concentrations were increased in women who developed preeclampsia, compared with normal pregnant women, and this increase was most pronounced in severe preeclampsia. However, many women with preeclampsia had soluble fms-like tyrosine kinase 1 concentrations similar to normal pregnant women. Lastly, soluble fms-like tyrosine kinase 1 decreased rapidly after delivery, but this decrease was significantly slower in women with severe preeclampsia.
  
  
  CONCLUSIONS
  Increased soluble fms-like tyrosine kinase 1 is not an early-pregnancy event among women who later develop preeclampsia. Increased soluble fms-like tyrosine kinase 1 is more likely to be present in women with severe preeclampsia, but it is not present in all women with preeclampsia. Soluble fms-like tyrosine kinase 1 concentrations decrease more slowly after delivery in women with preeclampsia, consistent with a decreased rate of excretion or continued production.
authors: Magee-Womens Research Institute and Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh, PA 15213, USA. rsirwp@mwri.magee.edu
authors: R W
authors: RW
authors: Powers
authors: J M
authors: JM
authors: Roberts
authors: K M
authors: KM
authors: Cooper
authors: M J
authors: MJ
authors: Gallaher
authors: M P
authors: MP
authors: Frank
authors: G F
authors: GF
authors: Harger
authors: R B
authors: RB
authors: Ness
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D007743:Labor, Obstetric / Q000097:blood; D009994:Osmolar Concentration; D049590:Postpartum Period / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy / Q000097:blood*; D011261:Pregnancy Trimester, First / Q000097:blood*; D012907:Smoking; D013997:Time Factors; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood*
chemical_list: D007527:Isoenzymes; D040281:Vascular Endothelial Growth Factor Receptor-1