Oral androstenedione-induced impotence and severe oligospermia.
OBJECTIVE
To report a case of androstenedione (A)-induced impotence and severe oligospermia.


METHODS
Case report.


METHODS
Multispecialty tertiary referral center.


METHODS
A 29-year-old married male recreational bodybuilder using the legal dietary supplement A in an attempt to enhance athletic performance.


METHODS
Immediate cessation of oral A, Depo-T regimen with a taper, administered during 3 months, to alleviate loss of libido and impotence.


METHODS
Resolution of symptoms and normalization of semen parameters.


RESULTS
Resolution of symptoms and normalization of semen parameters at 6 months, and successful intrauterine pregnancy achieved 1 year after initial presentation.


CONCLUSIONS
Oral A has a previously unrecognized side effect, which is the potential to suppress the hypothalamic pituitary gonadal axis.
Ritter
Robert H
RH
Division of Urology, Scott and White Memorial Hospital and Clinic, Scott, Sherwood & Brindley Foundation, The Texas A&M University System Health Science Center College of Medicine, Temple, Texas, USA.
Cryar
Anthony K
AK
Hermans
Michael R
MR
D000284:Administration, Oral; D000328:Adult; D000735:Androstenedione / Q000008:administration & dosage* / Q000009:adverse effects*; D007172:Erectile Dysfunction / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000139:chemically induced* / Q000175:diagnosis
D000735:Androstenedione