Activity of the hypothalamus-pituitary-adrenal system and oral glucose tolerance in depressed patients.
We hypothesized that the activity of the hypothalamus-pituitary-adrenal system in depressed patients is related to oral glucose tolerance. In 70 moderately depressed inpatients, we measured morning saliva cortisol for 6 days and assessed oral glucose tolerance. We found glucose concentrations to be positively associated with mean morning cortisol concentrations (F3,236 = 2.86, p < 0.05). Also, the ISI, a measure of insulin receptor sensitivity, was negatively associated with mean morning cortisol concentrations (r = -0.25, p < 0.04). These findings support the hypothesis that hypercortisolemia may lead to disturbed glucose utilization in depressed patients.
Weber-Hamann
Bettina
B
Central Institute of Mental Health, Mannheim, Campus Benjamin Franklin, Department of Psychiatry, Berlin, Germany.
Kopf
Daniel
D
Lederbogen
Florian
F
Gilles
Maria
M
Heuser
Isabella
I
Colla
Michael
M
Deuschle
Michael
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism*; D002940:Circadian Rhythm; D003863:Depression / Q000378:metabolism*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000378:metabolism*; D011972:Receptor, Insulin / Q000378:metabolism; D012463:Saliva / Q000378:metabolism; D018709:Statistics, Nonparametric
D001786:Blood Glucose; D011972:Receptor, Insulin; D006854:Hydrocortisone