Small inhibitory RNA--a tool for credentialing candidate genes.
The effect of a drug is related to the interaction of the numerous gene products that participate in a drug pathway. The clinical importance of genetic variability on the overall outcome of most drug pathways remains to be determined. As a result, there is a need to efficiently identify the genes that not only participate in the pathway but also play a significant role in regulating the effects of a drug. The emerging technique of specific gene silencing through RNA interference initiated by small inhibitory RNA may prove to be a useful and powerful tool in the credentialing of candidate genes in drug pathways.
Walgren
Richard A
RA
Washington University, School of Medicine, St. Louis, MO 63110, USA.
McLeod
Howard L
HL
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance / Q000235:genetics; D005786:Gene Expression Regulation / Q000187:drug effects*; D020868:Gene Silencing; D018390:Gene Targeting; D006801:Humans; D008954:Models, Biological; D010597:Pharmacogenetics; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use
D034741:RNA, Small Interfering