Regulation of Wnt gene expression.
Members of the Wnt gene family play important roles in the regulation of a number of basic developmental processes. Because Wnt is such a potent morphogen, its expression must be controlled tightly and precisely. While many review papers focused on Wnt signaling downstream of the receptor, this review addresses regulations of Wnt itself on several levels, including the transcriptional level, RNA splicing, the post-transcriptional level, the translational level, and the post-translational level. It is these multiple, precise and tight regulations that guarantee that Wnts function correctly both temporally and spatially.
Tian
Qi
Q
Department of Pathology, Oregon Health Sciences University, School of Medicine, Portland, OR 97239, USA. tianq@ohsu.edu
Jin
Hong
H
Cui
Yanzhen
Y
Guo
Changsheng
C
Lu
Xiang
X
D000818:Animals; D005786:Gene Expression Regulation; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D008954:Models, Biological; D011499:Protein Processing, Post-Translational; D012326:RNA Splicing; D014158:Transcription, Genetic; D051153:Wnt Proteins
D036341:Intercellular Signaling Peptides and Proteins; D051153:Wnt Proteins