title: Comparisons of the outcomes on control, type of management and complications status in early onset and late onset type 2 diabetes in Asia.
abstract: OBJECTIVE
  To describe the clinical characteristics and chronic diabetic complications in early (EOD) and late onset type 2 diabetes mellitus (LOD) in Asia.
  
  
  METHODS
  Retrospective collection of information (basic patient data, treatment received for diabetes, hypertension, dyslipidaemia, clinical measurements, complications, life-style management, etc.) on paper form and prospective collection of blood samples for HbA(1c) assessment were performed. Means, proportions and associated factors were analyzed using non-parametric and logistic regression.
  
  
  RESULTS
  The frequency of EOD (<30 years) varies in different Asian countries (0.4-5.3%). Overweight (BMI>or=23 kg/m2) was common in both EOD (60%) and LOD (66%). EOD was characterized by significantly higher levels of HbA(1c) (median 8.9% versus 7.9%) and FPG (median 9.8 mmol/L versus 8.3 mmol/L) but hypertension was less common (43% versus 59%). Lipid profiles (cholesterol and triglycerides) were similar between both groups of patients. Cataract was more common in LOD and was associated with onset age and diabetes duration whereas an increase in frequency of advanced eye disease, retinopathy and history of photocoagulation was found in EOD cohort.
  
  
  CONCLUSIONS
  In addition to diabetic control and duration of the disease, the onset age conferred risk to certain subsets of chronic complications in type 2 diabetes population.
authors: Department of Internal Medicine, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, Taiwan. leeming@ha.mc.ntu.edu.tw
authors: Lee-Ming
authors: LM
authors: Chuang
authors: Sidartawan
authors: S
authors: Soegondo
authors: Pradana
authors: P
authors: Soewondo
authors: Kim
authors: K
authors: Young-Seol
authors: Mafauzy
authors: M
authors: Mohamed
authors: Edith
authors: E
authors: Dalisay
authors: Ruby
authors: R
authors: Go
authors: Warren
authors: W
authors: Lee
authors: Tai
authors: T
authors: Tong-Yuan
authors: Sunthorn
authors: S
authors: Tandhanand
authors: Wannee
authors: W
authors: Nitiyanant
authors: Mai
authors: M
authors: The-Trach
authors: Clive
authors: C
authors: Cockram
authors: Yeo
authors: Y
authors: Jing-Ping
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D001208:Asia / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000453:epidemiology* / Q000628:therapy; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D015994:Incidence; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents