title: Cystic fibrosis modifier genes.
abstract: Since the recognition that CFTR genotype was not a good predictor of pulmonary disease severity in CF, several candidate modifier genes have been identified. It is unlikely that a single modifier gene will be found, but more probable that several haplotypes in combination may contribute, which in itself presents a major methodological challenge. The aims of such studies are to increase our understanding of disease pathogenesis, to aid prognosis and ultimately to lead to the development of novel treatments.
authors: Department of Gene Therapy, Faculty of Medicine, Imperial College, Emmanuel Kaye Building, Manresa Road, London, UK. j.c.davies@imperial.ac.uk
authors: Jane
authors: J
authors: Davies
authors: Eric
authors: E
authors: Alton
authors: Uta
authors: U
authors: Griesenbach
mesh_terms: D001424:Bacterial Infections / Q000150:complications / Q000235:genetics / Q000276:immunology; D003550:Cystic Fibrosis / Q000150:complications / Q000235:genetics* / Q000276:immunology; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics*; D005767:Gastrointestinal Diseases / Q000209:etiology / Q000235:genetics / Q000276:immunology; D006239:Haplotypes; D006801:Humans; D008107:Liver Diseases / Q000209:etiology / Q000235:genetics / Q000276:immunology; D010641:Phenotype; D011110:Polymorphism, Genetic; D012106:Research
chemical_list: C505032:CFTR protein, human; D019005:Cystic Fibrosis Transmembrane Conductance Regulator