Protective immunity associated with a strong serological response to a Cryptosporidium-specific antigen group, in HIV-infected individuals.
This study assessed whether serological responses to Cryptosporidium antigens are associated with a reduced risk of diarrheal illness in cases of infection with human immunodeficiency virus (HIV). The association between serological responses to the Cryptosporidium 15/17-kDa and 27-kDa antigen groups and reported diarrheal illness was examined by use of data from a previously published study of cases of HIV infection. In immunosuppressed individuals, a strong serological response to the 27-kDa antigen group was associated with a reduced risk of diarrhea without weight loss. This finding suggests that acquired protective immunity to cryptosporidiosis may be important in controlling the burden of cryptosporidiosis in immunosuppressed individuals.
Frost
Floyd J
FJ
Lovelace Respiratory Research Institute, University of New Mexico, and Lovelace Clinic Foundation, Albuquerque, New Mexico, USA.
Tollestrup
Kristine
K
Craun
Gunther F
GF
Fairley
Christopher K
CK
Sinclair
Martha I
MI
Kunde
Twila R
TR
D017088:AIDS-Related Opportunistic Infections / Q000276:immunology; D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000096:biosynthesis; D000953:Antigens, Protozoan / Q000276:immunology*; D018791:CD4 Lymphocyte Count; D003430:Cross-Sectional Studies; D003457:Cryptosporidiosis / Q000276:immunology*; D003458:Cryptosporidium / Q000276:immunology*; D003967:Diarrhea / Q000469:parasitology; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D016017:Odds Ratio
D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan